Sample records for producing large numbers
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Composite Overwrap Fragmentation Observations, Concerns, and Recommendations
NASA Technical Reports Server (NTRS)
Bangham, Mike; Hovater, Mary
2017-01-01
A series of test activities has raised some concerns about the generation of orbital debris caused by failures of composite overwrapped pressure vessels (COPVs). These tests have indicated that a large number of composite fragments can be produced by either pressure burst failures or by high-speed impacts. A review of prior high-speed tests with COPV indicates that other tests have produced large numbers of composite fragments. As was the case with the test referenced here, the tests tended to produce a large number of small composite fragments with relatively low velocities induced by the impact and or gas expansion.
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Development of a Charged-Particle Accumulator Using an RF Confinement Method
2007-03-12
antiparticles (antiprotons and positrons), and to produce a large quantity of antimatter . Antihydrogen atoms have recently been produced using Penning...ultimate goal is to trap a large number of antiparticles and to produce a large quantity of antimatter . 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF
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Broski, Scott A; King, B H
2017-02-01
One method of control of house flies, Musca domestica L. (Diptera: Muscidae), and other filth flies is by repeated release of large numbers of pupal parasitoids such as Spalangia endius Walker. Rearing these parasitoids may be facilitated by understanding how host factors affect their production. Previous studies have examined the effects of host size and host age on parasitoid production, but have not examined the interaction between host size and host age or the effects with older females, which may be less capable of drilling tough hosts. Females were given hosts of a single size-age category (small young, small old, large young, or large old) for 2 wk. The effect of host size and of host age on parasitoid production depended on female age. On their first day of oviposition, females produced more offspring from large than from small hosts, but host age had no significant effect. The cumulative number of parasitoids produced in the first week was not significantly affected by host size or host age. However, the cumulative number of parasitoids produced over 2 wk was affected by both host size and host age, with the greatest number of parasitoids produced from small young hosts. Thus, not only are smaller hosts cheaper to produce, but these results suggest that their use may have no effect or a positive effect on the number of parasitoids that can be produced when females are ovipositing for a week or two. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Yuzawa, Satoshi; Keasling, Jay D.; Katz, Leonard
Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. Finally, we have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.
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Yuzawa, Satoshi; Keasling, Jay D; Katz, Leonard
2017-04-01
Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.
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Data Mining of Extremely Large Ad Hoc Data Sets to Produce Inverted Indices
2016-06-01
NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited DATA MINING OF...COVERED Master’s Thesis 4. TITLE AND SUBTITLE DATA MINING OF EXTREMELY LARGE AD HOC DATA SETS TO PRODUCE INVERTED INDICES 5. FUNDING NUMBERS 6...INTENTIONALLY LEFT BLANK iii Approved for public release; distribution is unlimited DATA MINING OF EXTREMELY LARGE AD HOC DATA SETS TO PRODUCE
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NASA Astrophysics Data System (ADS)
Guervilly, C.; Cardin, P.
2017-12-01
Convection is the main heat transport process in the liquid cores of planets. The convective flows are thought to be turbulent and constrained by rotation (corresponding to high Reynolds numbers Re and low Rossby numbers Ro). Under these conditions, and in the absence of magnetic fields, the convective flows can produce coherent Reynolds stresses that drive persistent large-scale zonal flows. The formation of large-scale flows has crucial implications for the thermal evolution of planets and the generation of large-scale magnetic fields. In this work, we explore this problem with numerical simulations using a quasi-geostrophic approximation to model convective and zonal flows at Re 104 and Ro 10-4 for Prandtl numbers relevant for liquid metals (Pr 0.1). The formation of intense multiple zonal jets strongly affects the convective heat transport, leading to the formation of a mean temperature staircase. We also study the generation of magnetic fields by the quasi-geostrophic flows at low magnetic Prandtl numbers.
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Grade, Stéphane; Badets, Arnaud; Pesenti, Mauro
2017-05-01
Numerical magnitude and specific grasping action processing have been shown to interfere with each other because some aspects of numerical meaning may be grounded in sensorimotor transformation mechanisms linked to finger grip control. However, how specific these interactions are to grasping actions is still unknown. The present study tested the specificity of the number-grip relationship by investigating how the observation of different closing-opening stimuli that might or not refer to prehension-releasing actions was able to influence a random number generation task. Participants had to randomly produce numbers after they observed action stimuli representing either closure or aperture of the fingers, the hand or the mouth, or a colour change used as a control condition. Random number generation was influenced by the prior presentation of finger grip actions, whereby observing a closing finger grip led participants to produce small rather than large numbers, whereas observing an opening finger grip led them to produce large rather than small numbers. Hand actions had reduced or no influence on number production; mouth action influence was restricted to opening, with an overproduction of large numbers. Finally, colour changes did not influence number generation. These results show that some characteristics of observed finger, hand and mouth grip actions automatically prime number magnitude, with the strongest effect for finger grasping. The findings are discussed in terms of the functional and neural mechanisms shared between hand actions and number processing, but also between hand and mouth actions. The present study provides converging evidence that part of number semantics is grounded in sensory-motor mechanisms.
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Robust Airfoil Optimization in High Resolution Design Space
NASA Technical Reports Server (NTRS)
Li, Wu; Padula, Sharon L.
2003-01-01
The robust airfoil shape optimization is a direct method for drag reduction over a given range of operating conditions and has three advantages: (1) it prevents severe degradation in the off-design performance by using a smart descent direction in each optimization iteration, (2) it uses a large number of B-spline control points as design variables yet the resulting airfoil shape is fairly smooth, and (3) it allows the user to make a trade-off between the level of optimization and the amount of computing time consumed. The robust optimization method is demonstrated by solving a lift-constrained drag minimization problem for a two-dimensional airfoil in viscous flow with a large number of geometric design variables. Our experience with robust optimization indicates that our strategy produces reasonable airfoil shapes that are similar to the original airfoils, but these new shapes provide drag reduction over the specified range of Mach numbers. We have tested this strategy on a number of advanced airfoil models produced by knowledgeable aerodynamic design team members and found that our strategy produces airfoils better or equal to any designs produced by traditional design methods.
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Large-scale production of embryonic red blood cells from human embryonic stem cells.
Olivier, Emmanuel N; Qiu, Caihong; Velho, Michelle; Hirsch, Rhoda Elison; Bouhassira, Eric E
2006-12-01
To develop a method to produce in culture large number of erythroid cells from human embryonic stem cells. Human H1 embryonic stem cells were differentiated into hematopoietic cells by coculture with a human fetal liver cell line, and the resulting CD34-positive cells were expanded in vitro in liquid culture using a three-step method. The erythroid cells produced were then analyzed by light microscopy and flow cytometry. Globin expression was characterized by quantitative reverse-transcriptase polymerase chain reaction and by high-performance liquid chromatography. CD34-positive cells produced from human embryonic stem cells could be efficiently differentiated into erythroid cells in liquid culture leading to a more than 5000-fold increase in cell number. The erythroid cells produced are similar to primitive erythroid cells present in the yolk sac of early human embryos and did not enucleate. They are fully hemoglobinized and express a mixture of embryonic and fetal globins but no beta-globin. We have developed an experimental protocol to produce large numbers of primitive erythroid cells starting from undifferentiated human embryonic stem cells. As the earliest human erythroid cells, the nucleated primitive erythroblasts, are not very well characterized because experimental material at this stage of development is very difficult to obtain, this system should prove useful to answer a number of experimental questions regarding the biology of these cells. In addition, production of mature red blood cells from human embryonic stem cells is of great potential practical importance because it could eventually become an alternate source of cell for transfusion.
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A full picture of large lepton number asymmetries of the Universe
DOE Office of Scientific and Technical Information (OSTI.GOV)
Barenboim, Gabriela; Park, Wan-Il, E-mail: Gabriela.Barenboim@uv.es, E-mail: wipark@jbnu.ac.kr
A large lepton number asymmetry of O(0.1−1) at present Universe might not only be allowed but also necessary for consistency among cosmological data. We show that, if a sizeable lepton number asymmetry were produced before the electroweak phase transition, the requirement for not producing too much baryon number asymmetry through sphalerons processes, forces the high scale lepton number asymmetry to be larger than about 03. Therefore a mild entropy release causing O(10-100) suppression of pre-existing particle density should take place, when the background temperature of the Universe is around T = O(10{sup −2}-10{sup 2}) GeV for a large but experimentallymore » consistent asymmetry to be present today. We also show that such a mild entropy production can be obtained by the late-time decays of the saxion, constraining the parameters of the Peccei-Quinn sector such as the mass and the vacuum expectation value of the saxion field to be m {sub φ} ∼> O(10) TeV and φ{sub 0} ∼> O(10{sup 14}) GeV, respectively.« less
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Low Reynolds number numerical solutions of chaotic flow
NASA Technical Reports Server (NTRS)
Pulliam, Thomas H.
1989-01-01
Numerical computations of two-dimensional flow past an airfoil at low Mach number, large angle of attack, and low Reynolds number are reported which show a sequence of flow states leading from single-period vortex shedding to chaos via the period-doubling mechanism. Analysis of the flow in terms of phase diagrams, Poincare sections, and flowfield variables are used to substantiate these results. The critical Reynolds number for the period-doubling bifurcations is shown to be sensitive to mesh refinement and the influence of large amounts of numerical dissipation. In extreme cases, large amounts of added dissipation can delay or completely eliminate the chaotic response. The effect of artificial dissipation at these low Reynolds numbers is to produce a new effective Reynolds number for the computations.
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Degree-days as a tool for use in producing tilapia fry for sex inversion
USDA-ARS?s Scientific Manuscript database
Hormonal sex inversion of newly hatched tilapia fry continues to be an important method to produce monosex male tilapia fingerlings. Large numbers of tilapia fry suitable for sex inversion can be produced by periodic complete harvest of earthen reproduction ponds. Traditionally, harvest interval was...
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Preferential Mating in Symmetric Multilocus Systems: Limits for Multiallelism and for Many Loci
Raper, J.
1982-01-01
Models in which general forms of preferential mating have been superimposed on the framework of the symmetric heterozygosity selection regime have been examined previously with respect to the existence and local stability of a central polymorphic equilibrium. The results are now extended to produce the limiting form of the stability conditions in two cases: First, where the number of alleles per locus is assumed to be very large; second, where the number of loci affecting the character is very large. It is argued that some type of frequency dependence in the mating pattern must be included, and a particular case is examined in detail. It is shown that multiallelism is ambiguous in its effect on stability, while an increasing number of loci, at least under zero linkage, leads to a simple stability condition which is analogous to the one-locus heterosis principle. Assortative mating appears to be more likely to produce a stable central polymorphism under high levels of allelism than is sexual selection, but is relatively very much weaker than sexual or viability selection if the number of loci involved is large. PMID:17246061
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Process for producing fine and ultrafine filament superconductor wire
Kanithi, H.C.
1992-02-18
A process for producing a superconductor wire made up of a large number of round monofilament rods is provided for, comprising assembling a multiplicity of round monofilaments inside each of a multiplicity of thin wall hexagonal tubes and then assembling a number of said thin wall hexagonal tubes within an extrusion can and subsequently consolidating, extruding and drawing the entire assembly down to the desired wire size. 8 figs.
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Process for producing fine and ultrafine filament superconductor wire
Kanithi, Hem C.
1992-01-01
A process for producing a superconductor wire made up of a large number of round monofilament rods is provided for, comprising assembling a multiplicity of round monofilaments inside each of a multiplicity of thin wall hexagonal tubes and then assembling a number of said thin wall hexagonal tubes within an extrusion can and subsequently consolidating, extruding and drawing the entire assembly down to the desired wire size.
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On the effects of viscosity on the stability of a trailing-line vortex
NASA Technical Reports Server (NTRS)
Duck, Peter W.; Khorrami, Mehdi R.
1991-01-01
The linear stability of the Batchelor (1964) vortex is investigated. Particular emphasis is placed on modes found recently in a numerical study by Khorrami (1991). These modes have a number of features very distinct from those found previously for this vortex, including exhibiting small growth rates at large Reynolds numbers and susceptibility to destabilization by viscosity. These modes are described using asymptotic techniques, producing results which compare favorably with fully numerical results at large Reynolds numbers.
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Monroe, J Grey; Allen, Zachariah A; Tanger, Paul; Mullen, Jack L; Lovell, John T; Moyers, Brook T; Whitley, Darrell; McKay, John K
2017-01-01
Recent advances in nucleic acid sequencing technologies have led to a dramatic increase in the number of markers available to generate genetic linkage maps. This increased marker density can be used to improve genome assemblies as well as add much needed resolution for loci controlling variation in ecologically and agriculturally important traits. However, traditional genetic map construction methods from these large marker datasets can be computationally prohibitive and highly error prone. We present TSPmap , a method which implements both approximate and exact Traveling Salesperson Problem solvers to generate linkage maps. We demonstrate that for datasets with large numbers of genomic markers (e.g. 10,000) and in multiple population types generated from inbred parents, TSPmap can rapidly produce high quality linkage maps with low sensitivity to missing and erroneous genotyping data compared to two other benchmark methods, JoinMap and MSTmap . TSPmap is open source and freely available as an R package. With the advancement of low cost sequencing technologies, the number of markers used in the generation of genetic maps is expected to continue to rise. TSPmap will be a useful tool to handle such large datasets into the future, quickly producing high quality maps using a large number of genomic markers.
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United States Geological Survey fire science: fire danger monitoring and forecasting
Eidenshink, Jeff C.; Howard, Stephen M.
2012-01-01
Each day, the U.S. Geological Survey produces 7-day forecasts for all Federal lands of the distributions of number of ignitions, number of fires above a given size, and conditional probabilities of fires growing larger than a specified size. The large fire probability map is an estimate of the likelihood that ignitions will become large fires. The large fire forecast map is a probability estimate of the number of fires on federal lands exceeding 100 acres in the forthcoming week. The ignition forecast map is a probability estimate of the number of fires on Federal land greater than 1 acre in the forthcoming week. The extreme event forecast is the probability estimate of the number of fires on Federal land that may exceed 5,000 acres in the forthcoming week.
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ERIC Educational Resources Information Center
Peurach, Donald J.; Lenhoff, Sarah Winchell; Glazer, Joshua L.
2016-01-01
Recognizing school improvement networks as a leading strategy for large-scale high school reform, this analysis examines developmental evaluation as an approach to examining school improvement networks as "learning systems" able to produce, use, and refine practical knowledge in large numbers of schools. Through a case study of one…
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Pollen-limited reproduction in blue oak: Implications for wind pollination in fragmented populations
Knapp, E.E.; Goedde, M.A.; Rice, K.J.
2001-01-01
Human activities are fragmenting forests and woodlands worldwide, but the impact of reduced tree population densities on pollen transfer in wind-pollinated trees is poorly understood. In a 4-year study, we evaluated relationships among stand density, pollen availability, and seed production in a thinned and fragmented population of blue oak (Quercus douglasii). Geographic coordinates were established and flowering interval determined for 100 contiguous trees. The number of neighboring trees within 60 m that released pollen during each tree's flowering period was calculated and relationships with acorn production explored using multiple regression. We evaluated the effects of female flower production, average temperature, and relative humidity during the pollination period, and number of pollen-producing neighbors on individual trees' acorn production. All factors except temperature were significant in at least one of the years of our study, but the combination of factors influencing acorn production varied among years. In 1996, a year of large acorn crop size, acorn production was significantly positively associated with number of neighboring pollen producers and density of female flowers. In 1997, 1998, and 1999, many trees produced few or no acorns, and significant associations between number of pollen-producing neighbors and acorn production were only apparent among moderately to highly reproductive trees. Acorn production by these reproductive trees in 1997 was significantly positively associated with number of neighboring pollen producers and significantly negatively associated with average relative humidity during the pollination period. In 1998, no analysis was possible, because too few trees produced a moderate to large acorn crop. Only density of female flowers was significantly associated with acorn production of moderately to highly reproductive trees in 1999. The effect of spatial scale was also investigated by conducting analyses with pollen producers counted in radii ranging from 30 m to 80 m. The association between number of pollen-producing neighbors and acorn production was strongest when neighborhood sizes of 60 m or larger were considered. Our results suggest that fragmentation and thinning of blue oak woodlands may reduce pollen availability and limit reproduction in this wind-pollinated species.
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Publication Bias in Meta-Analysis: Confidence Intervals for Rosenthal's Fail-Safe Number.
Fragkos, Konstantinos C; Tsagris, Michail; Frangos, Christos C
2014-01-01
The purpose of the present paper is to assess the efficacy of confidence intervals for Rosenthal's fail-safe number. Although Rosenthal's estimator is highly used by researchers, its statistical properties are largely unexplored. First of all, we developed statistical theory which allowed us to produce confidence intervals for Rosenthal's fail-safe number. This was produced by discerning whether the number of studies analysed in a meta-analysis is fixed or random. Each case produces different variance estimators. For a given number of studies and a given distribution, we provided five variance estimators. Confidence intervals are examined with a normal approximation and a nonparametric bootstrap. The accuracy of the different confidence interval estimates was then tested by methods of simulation under different distributional assumptions. The half normal distribution variance estimator has the best probability coverage. Finally, we provide a table of lower confidence intervals for Rosenthal's estimator.
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Publication Bias in Meta-Analysis: Confidence Intervals for Rosenthal's Fail-Safe Number
Fragkos, Konstantinos C.; Tsagris, Michail; Frangos, Christos C.
2014-01-01
The purpose of the present paper is to assess the efficacy of confidence intervals for Rosenthal's fail-safe number. Although Rosenthal's estimator is highly used by researchers, its statistical properties are largely unexplored. First of all, we developed statistical theory which allowed us to produce confidence intervals for Rosenthal's fail-safe number. This was produced by discerning whether the number of studies analysed in a meta-analysis is fixed or random. Each case produces different variance estimators. For a given number of studies and a given distribution, we provided five variance estimators. Confidence intervals are examined with a normal approximation and a nonparametric bootstrap. The accuracy of the different confidence interval estimates was then tested by methods of simulation under different distributional assumptions. The half normal distribution variance estimator has the best probability coverage. Finally, we provide a table of lower confidence intervals for Rosenthal's estimator. PMID:27437470
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REPRODUCTIVE EFFECTS ASSESSMENT GROUP'S REVIEW OF THE MUTAGENICITY OF VINYLIDENE CHLORIDE
A large number of studies indicate that vinylidene chloride is mutagenic to bacteria and that this activity is largely dependent on microsomal activation. Vinylidene chloride was reported to produce positive results for gene reversion and conversion in yeast, which was also depen...
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USDA-ARS?s Scientific Manuscript database
Insect diets are often complex mixtures of vitamins, salts, preservatives, and nutrients (carbohydrates, lipids and proteins). To determine the effect of varying the doses of multiple components, the traditional approach requires large factorial experiments resulting in very large numbers of treat...
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Large atom number Bose-Einstein condensate machines
DOE Office of Scientific and Technical Information (OSTI.GOV)
Streed, Erik W.; Chikkatur, Ananth P.; Gustavson, Todd L.
2006-02-15
We describe experimental setups for producing large Bose-Einstein condensates of {sup 23}Na and {sup 87}Rb. In both, a high-flux thermal atomic beam is decelerated by a Zeeman slower and is then captured and cooled in a magneto-optical trap. The atoms are then transferred into a cloverleaf-style Ioffe-Pritchard magnetic trap and cooled to quantum degeneracy with radio-frequency-induced forced evaporation. Typical condensates contain 20x10{sup 6} atoms. We discuss the similarities and differences between the techniques used for producing large {sup 87}Rb and {sup 23}Na condensates in the context of nearly identical setups.
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Topological Properties of Some Integrated Circuits for Very Large Scale Integration Chip Designs
NASA Astrophysics Data System (ADS)
Swanson, S.; Lanzerotti, M.; Vernizzi, G.; Kujawski, J.; Weatherwax, A.
2015-03-01
This talk presents topological properties of integrated circuits for Very Large Scale Integration chip designs. These circuits can be implemented in very large scale integrated circuits, such as those in high performance microprocessors. Prior work considered basic combinational logic functions and produced a mathematical framework based on algebraic topology for integrated circuits composed of logic gates. Prior work also produced an historically-equivalent interpretation of Mr. E. F. Rent's work for today's complex circuitry in modern high performance microprocessors, where a heuristic linear relationship was observed between the number of connections and number of logic gates. This talk will examine topological properties and connectivity of more complex functionally-equivalent integrated circuits. The views expressed in this article are those of the author and do not reflect the official policy or position of the United States Air Force, Department of Defense or the U.S. Government.
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Aerodynamics and vortical structures in hovering fruitflies
NASA Astrophysics Data System (ADS)
Meng, Xue Guang; Sun, Mao
2015-03-01
We measure the wing kinematics and morphological parameters of seven freely hovering fruitflies and numerically compute the flows of the flapping wings. The computed mean lift approximately equals to the measured weight and the mean horizontal force is approximately zero, validating the computational model. Because of the very small relative velocity of the wing, the mean lift coefficient required to support the weight is rather large, around 1.8, and the Reynolds number of the wing is low, around 100. How such a large lift is produced at such a low Reynolds number is explained by combining the wing motion data, the computed vortical structures, and the theory of vorticity dynamics. It has been shown that two unsteady mechanisms are responsible for the high lift. One is referred as to "fast pitching-up rotation": at the start of an up- or downstroke when the wing has very small speed, it fast pitches down to a small angle of attack, and then, when its speed is higher, it fast pitches up to the angle it normally uses. When the wing pitches up while moving forward, large vorticity is produced and sheds at the trailing edge, and vorticity of opposite sign is produced near the leading edge and on the upper surface, resulting in a large time rate of change of the first moment of vorticity (or fluid impulse), hence a large aerodynamic force. The other is the well known "delayed stall" mechanism: in the mid-portion of the up- or downstroke the wing moves at large angle of attack (about 45 deg) and the leading-edge-vortex (LEV) moves with the wing; thus, the vortex ring, formed by the LEV, the tip vortices, and the starting vortex, expands in size continuously, producing a large time rate of change of fluid impulse or a large aerodynamic force.
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Design rules for quasi-linear nonlinear optical structures
NASA Astrophysics Data System (ADS)
Lytel, Richard; Mossman, Sean M.; Kuzyk, Mark G.
2015-09-01
The maximization of the intrinsic optical nonlinearities of quantum structures for ultrafast applications requires a spectrum scaling as the square of the energy eigenstate number or faster. This is a necessary condition for an intrinsic response approaching the fundamental limits. A second condition is a design generating eigenstates whose ground and lowest excited state probability densities are spatially separated to produce large differences in dipole moments while maintaining a reasonable spatial overlap to produce large off-diagonal transition moments. A structure whose design meets both conditions will necessarily have large first or second hyperpolarizabilities. These two conditions are fundamental heuristics for the design of any nonlinear optical structure.
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Mapping the acquisition of the number word sequence in the first year of school
NASA Astrophysics Data System (ADS)
Gould, Peter
2017-03-01
Learning to count and to produce the correct sequence of number words in English is not a simple process. In NSW government schools taking part in Early Action for Success, over 800 students in each of the first 3 years of school were assessed every 5 weeks over the school year to determine the highest correct oral count they could produce. Rather than displaying a steady increase in the accurate sequence of the number words produced, the kindergarten data reported here identified clear, substantial hurdles in the acquisition of the counting sequence. The large-scale, longitudinal data also provided evidence of learning to count through the teens being facilitated by the semi-regular structure of the number words in English. Instead of occurring as hurdles to starting the next counting sequence, number words corresponding to some multiples of ten (10, 20 and 100) acted as if they were rest points. These rest points appear to be artefacts of how the counting sequence is acquired.
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Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurri, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Copic, K; Cordelli, M; Cortiana, G; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kusakabe, Y; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, S W; Leone, S; Lewis, J D; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morello, M J; Morlok, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Tu, Y; Turini, N; Ukegawa, F; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Xie, S; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S
2008-10-31
We present the results of searches for large extra dimensions in samples of events with large missing transverse energy E_{T} and either a photon or a jet produced in pp[over ] collisions at sqrt[s]=1.96 TeV collected with the Collider Detector at Fermilab II. For gamma+E_{T} and jet+E_{T} candidate samples corresponding to 2.0 and 1.1 fb;{-1} of integrated luminosity, respectively, we observe good agreement with standard model expectations and obtain a combined lower limit on the fundamental parameter of the large extra dimensions model M_{D} as a function of the number of extra dimensions in the model.
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Glisić, Radmila; Koko, Vesna; Todorović, Vera; Drndarević, Neda; Cvijić, Gordana
2006-09-11
The aim of our study was to investigate the morphological, immunohistochemical and ultrastructural changes of rat serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats (D). After 12-daily intraperitoneal administration of 2 mg/kg dexamethasone, rats developed diabetes similar to human diabetes type 2. Stomach, small and large intestines were examined. Large serotonin positive EC cells appeared in the corpus mucosa epithelium of D group of rats, although these cells were not present in control (C) rats. Both volume fraction and the number of EC cells per mm(2) of mucosa were significantly increased only in the duodenum. However, the number of EC cells per circular sections of both antrum and small intestine was increased, but reduced both in the ascending and descending colon in D group. The dexamethasone treatment caused a strong reduction in number of granules in the antral EC cells, while it was gradually increased beginning from the jejunum to descending colon. The mean granular content was reduced in the antral EC cells but increased in the jejunal EC cells in D group. In conclusion, the present study showed that morphological changes in gut serotonin-producing EC cells occurred in diabetic rats.
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Trichinella spiralis in human muscle (image)
This is the parasite Trichinella spiralis in human muscle tissue. The parasite is transmitted by eating undercooked meats, especially pork. The cysts hatch in the intestines and produce large numbers of ...
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Hanning, Irene B; Nutt, J D; Ricke, Steven C
2009-01-01
Foodborne Salmonella spp. is a leading cause of foodborne illness in the United States each year. Traditionally, most cases of salmonellosis were thought to originate from meat and poultry products. However, an increasing number of salmonellosis outbreaks are occurring as a result of contaminated produce. Several produce items specifically have been identified in outbreaks, and the ability of Salmonella to attach or internalize into vegetables and fruits may be factors that make these produce items more likely to be sources of Salmonella. In addition, environmental factors including contaminated water sources used to irrigate and wash produce crops have been implicated in a large number of outbreaks. Salmonella is carried by both domesticated and wild animals and can contaminate freshwater by direct or indirect contact. In some cases, direct contact of produce or seeds with contaminated manure or animal wastes can lead to contaminated crops. This review examines outbreaks of Salmonella due to contaminated produce, the potential sources of Salmonella, and possible control measures to prevent contamination of produce.
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Quality Assurance in Large Scale Online Course Production
ERIC Educational Resources Information Center
Holsombach-Ebner, Cinda
2013-01-01
The course design and development process (often referred to here as the "production process") at Embry-Riddle Aeronautical University (ERAU-Worldwide) aims to produce turnkey style courses to be taught by a highly-qualified pool of over 800 instructors. Given the high number of online courses and tremendous number of live sections…
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A Reynolds Number Study of Wing Leading-Edge Effects on a Supersonic Transport Model at Mach 0.3
NASA Technical Reports Server (NTRS)
Williams, M. Susan; Owens, Lewis R., Jr.; Chu, Julio
1999-01-01
A representative supersonic transport design was tested in the National Transonic Facility (NTF) in its original configuration with small-radius leading-edge flaps and also with modified large-radius inboard leading-edge flaps. Aerodynamic data were obtained over a range of Reynolds numbers at a Mach number of 0.3 and angles of attack up to 16 deg. Increasing the radius of the inboard leading-edge flap delayed nose-up pitching moment to a higher lift coefficient. Deflecting the large-radius leading-edge flap produced an overall decrease in lift coefficient and delayed nose-up pitching moment to even higher angles of attack as compared with the undeflected large- radius leading-edge flap. At angles of attack corresponding to the maximum untrimmed lift-to-drag ratio, lift and drag coefficients decreased while lift-to-drag ratio increased with increasing Reynolds number. At an angle of attack of 13.5 deg., the pitching-moment coefficient was nearly constant with increasing Reynolds number for both the small-radius leading-edge flap and the deflected large-radius leading-edge flap. However, the pitching moment coefficient increased with increasing Reynolds number for the undeflected large-radius leading-edge flap above a chord Reynolds number of about 35 x 10 (exp 6).
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MGIS: Managing banana (Musa spp.) genetic resources information and high-throughput genotyping data
USDA-ARS?s Scientific Manuscript database
Unraveling genetic diversity held in genebanks on a large scale is underway, due to the advances in Next-generation sequence-based technologies that produce high-density genetic markers for a large number of samples at low cost. Genebank users should be in a position to identify and select germplasm...
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Optimal reproduction strategies in two species of mound-building termites.
Cameron, David A; Ivers, David J; Evans, Theodore A; Myerscough, Mary R
2008-01-01
We formulate a mathematical model for food collection and production of workers and nymphs in 2 species of mound building termites. We maximise the number of nymphs (reproductives) produced by each colony over its lifetime with respect to the proportion of eggs that hatch as nymphs as opposed to workers. The results predict that food storage has a very important influence on the pattern of nymph and worker production. Food storage affects the part of the year that nymph production dominates, whether nymphs and workers are produced at the same time or not, and the existence of a final phase in the colony's life when a very large number of nymphs but no workers are produced.
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Synthetic Modifications In the Frequency Domain for Finite Element Model Update and Damage Detection
2017-09-01
Sensitivity-based finite element model updating and structural damage detection has been limited by the number of modes available in a vibration test and...increase the number of modes and corresponding sensitivity data by artificially constraining the structure under test, producing a large number of... structural modifications to the measured data, including both springs-to-ground and mass modifications. This is accomplished with frequency domain
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Integrated analysis of energy transfers in elastic-wave turbulence.
Yokoyama, Naoto; Takaoka, Masanori
2017-08-01
In elastic-wave turbulence, strong turbulence appears in small wave numbers while weak turbulence does in large wave numbers. Energy transfers in the coexistence of these turbulent states are numerically investigated in both the Fourier space and the real space. An analytical expression of a detailed energy balance reveals from which mode to which mode energy is transferred in the triad interaction. Stretching energy excited by external force is transferred nonlocally and intermittently to large wave numbers as the kinetic energy in the strong turbulence. In the weak turbulence, the resonant interactions according to the weak turbulence theory produce cascading net energy transfer to large wave numbers. Because the system's nonlinearity shows strong temporal intermittency, the energy transfers are investigated at active and moderate phases separately. The nonlocal interactions in the Fourier space are characterized by the intermittent bundles of fibrous structures in the real space.
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Statistical model for forecasting monthly large wildfire events in western United States
Haiganoush K. Preisler; Anthony L. Westerling
2006-01-01
The ability to forecast the number and location of large wildfire events (with specified confidence bounds) is important to fire managers attempting to allocate and distribute suppression efforts during severe fire seasons. This paper describes the development of a statistical model for assessing the forecasting skills of fire-danger predictors and producing 1-month-...
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Bridging the gap between strategic and management forest inventories
Ronald E. McRoberts
2009-01-01
Strategic forest inventory programs collect information for a large number of variables on a relatively sparse array of field plots. Data from these inventories are used to produce estimates for large areas such as states and provinces, regions, or countries. The purpose of management forest inventories is to guide management decisions for small areas such as stands....
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"Conversing" in French: The Effect of High-Stakes Environments on Oral Task Performance
ERIC Educational Resources Information Center
de Saint Léger, Diane; Storch, Neomy
2012-01-01
Tasks can vary in terms of difficulty and implementation conditions, and these in turn may affect the nature of the language produced by the learner. There have been a large number of studies which have investigated the effects of these task properties and implementation conditions on the language the learner produces. To date, results have been…
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Large Eddy Simulation in the Computation of Jet Noise
NASA Technical Reports Server (NTRS)
Mankbadi, R. R.; Goldstein, M. E.; Povinelli, L. A.; Hayder, M. E.; Turkel, E.
1999-01-01
Noise can be predicted by solving Full (time-dependent) Compressible Navier-Stokes Equation (FCNSE) with computational domain. The fluctuating near field of the jet produces propagating pressure waves that produce far-field sound. The fluctuating flow field as a function of time is needed in order to calculate sound from first principles. Noise can be predicted by solving the full, time-dependent, compressible Navier-Stokes equations with the computational domain extended to far field - but this is not feasible as indicated above. At high Reynolds number of technological interest turbulence has large range of scales. Direct numerical simulations (DNS) can not capture the small scales of turbulence. The large scales are more efficient than the small scales in radiating sound. The emphasize is thus on calculating sound radiated by large scales.
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A Design Tool for Matching UAV Propeller and Power Plant Performance
NASA Astrophysics Data System (ADS)
Mangio, Arion L.
A large body of knowledge is available for matching propellers to engines for large propeller driven aircraft. Small UAV's and model airplanes operate at much lower Reynolds numbers and use fixed pitch propellers so the information for large aircraft is not directly applicable. A design tool is needed that takes into account Reynolds number effects, allows for gear reduction, and the selection of a propeller optimized for the airframe. The tool developed in this thesis does this using propeller performance data generated from vortex theory or wind tunnel experiments and combines that data with an engine power curve. The thrust, steady state power, RPM, and tip Mach number vs. velocity curves are generated. The Reynolds number vs. non dimensional radial station at an operating point is also found. The tool is then used to design a geared power plant for the SAE Aero Design competition. To measure the power plant performance, a purpose built engine test stand was built. The characteristics of the engine test stand are also presented. The engine test stand was then used to characterize the geared power plant. The power plant uses a 26x16 propeller, 100/13 gear ratio, and an LRP 0.30 cubic inch engine turning at 28,000 RPM and producing 2.2 HP. Lastly, the measured power plant performance is presented. An important result is that 17 lbf of static thrust is produced.
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Two-Dimensional Planar Lightwave Circuit Integrated Spatial Filter Array and Method of Use Thereof
NASA Technical Reports Server (NTRS)
Dimov, Fedor (Inventor); Ai, Jun (Inventor)
2015-01-01
A large coherent two-dimensional (2D) spatial filter array (SFA), 30 by 30 or larger, is produced by coupling a 2D planar lightwave circuit (PLC) array with a pair of lenslet arrays at the input and output side. The 2D PLC array is produced by stacking a plurality of chips, each chip with a plural number of straight PLC waveguides. A pupil array is coated onto the focal plane of the lenslet array. The PLC waveguides are produced by deposition of a plural number of silica layers on the silicon wafer, followed by photolithography and reactive ion etching (RIE) processes. A plural number of mode filters are included in the silica-on-silicon waveguide such that the PLC waveguide is transparent to the fundamental mode but higher order modes are attenuated by 40 dB or more.
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Vinderola, Gabriel; Perdigón, Gabriela; Duarte, Jairo; Farnworth, Edward; Matar, Chantal
2006-12-01
The probiotic effects ascribed to lactic acid bacteria (LAB) and their fermented dairy products arise not only from whole microorganisms and cell wall components but also from peptides and extracellular polysaccharides (exopolysaccharides) produced during the fermentation of milk. There is a lack of knowledge concerning the immune mechanisms induced by exopolysaccharides produced by lactic acid bacteria, which would allow a better understanding of the functional effects described to them. The aim of this study was to investigate the in vivo immunomodulating capacity of the exopolysaccharide produced by Lactobacillus kefiranofaciens by analyzing the profile of cytokines and immunoglobulins induced at the intestinal mucosa level, in the intestinal fluid and blood serum. BALB/c mice received the exopolysaccharide produced by L. kefiranofaciens for 2, 5 or 7 consecutive days. At the end of each period of administration, control and treated mice were sacrificed and the numbers of IgA+ and IgG+ cells were determined on histological slices of the small and large intestine by immunofluorescence. Cytokines (IL-4, IL-6, IL-10, IL-12, IFNgamma and TNFalpha) were also determined in the gut lamina propria as well as in the intestinal fluid and blood serum. There was an increase of IgA+ cells in the small and large intestine lamina propria, without change in the number of IgG+ cells in the small intestine. This study reports the effects of the oral administration of the exopolysaccharide produced by L. kefiranofaciens in the number of IgA+ cells in the small and large intestine, comparing simultaneously the production of cytokines by cells of the lamina propria and in the intestinal fluid and blood serum. The increase in the number of IgA+ cells was not simultaneously accompanied by an enhance of the number of IL-4+ cells in the small intestine. This finding would be in accordance with the fact that, in general, polysaccharide antigens elicit a T-independent immune response. For IL-10+, IL-6+ and IL-12+ cells, the values found were slightly increased compared to control values, while IFNgamma+ and TNFalpha+ cells did not change compared to control values. The effects observed on immunoglobulins and in all the cytokines assayed in the large intestine after kefiran administration were of greater magnitude than the ones observed in the small intestine lamina propria, which may be due to the saccharolytic action of the colonic microflora. In the intestinal fluid, only IL-4 and IL-12 increased compared to control values. In blood serum, all the cytokines assayed followed a pattern of production quite similar to the one found for them in the small intestine lamina propria. We observed that the exopolysaccharide induced a gut mucosal response and it was able to up and down regulate it for protective immunity, maintaining intestinal homeostasis, enhancing the IgA production at both the small and large intestine level and influencing the systemic immunity through the cytokines released to the circulating blood.
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Large displacement spring-like electro-mechanical thermal actuators with insulator constraint beams
NASA Astrophysics Data System (ADS)
Luo, J. K.; Fu, Y. Q.; Flewitt, A. J.; Spearing, S. M.; Fleck, N. A.; Milne, W. I.
2005-07-01
A number of in-plane spring-like micro-electro-thermal-actuators with large displacements were proposed. The devices take the advantage of the large difference in the thermal expansion coefficients between the conductive arms and the insulator clamping beams. The constraint beams in one type (the spring) of these devices are horizontally positioned to restrict the expansion of the active arms in the x-direction, and to produce a displacement in the y-direction only. In other two types of actuators (the deflector and the contractor), the constraint beams are positioned parallel to the active arms. When the constraint beams are on the inside of the active arms, the actuator produces an outward deflection in the y-direction. When they are on the outside of the active arms, the actuator produces an inward contraction. Analytical model and finite element analysis were used to simulate the performances. It showed that at a constant temperature, analytical model is sufficient to predict the displacement of these devices. The displacements are all proportional to the temperature and the number of the chevron sections. A two-mask process is under development to fabricate these devices, using Si3N4 as the insulator beams, and electroplated Ni as the conductive beams.
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Food stress causes sex-specific maternal effects in mites
Walzer, Andreas; Schausberger, Peter
2015-01-01
ABSTRACT Life history theory predicts that females should produce few large eggs under food stress and many small eggs when food is abundant. We tested this prediction in three female-biased size-dimorphic predatory mites feeding on herbivorous spider mite prey: Phytoseiulus persimilis, a specialized spider mite predator; Neoseiulus californicus, a generalist preferring spider mites; Amblyseius andersoni, a broad diet generalist. Irrespective of predator species and offspring sex, most females laid only one small egg under severe food stress. Irrespective of predator species, the number of female but not male eggs decreased with increasing maternal food stress. This sex-specific effect was probably due to the higher production costs of large female than small male eggs. The complexity of the response to the varying availability of spider mite prey correlated with the predators' degree of adaptation to this prey. Most A. andersoni females did not oviposit under severe food stress, whereas N. californicus and P. persimilis did oviposit. Under moderate food stress, only P. persimilis increased its investment per offspring, at the expense of egg number, and produced few large female eggs. When prey was abundant, P. persimilis decreased the female egg sizes at the expense of increased egg numbers, resulting in a sex-specific egg size/number trade-off. Maternal effects manifested only in N. californicus and P. persimilis. Small egg size correlated with the body size of daughters but not sons. Overall, our study provides a key example of sex-specific maternal effects, i.e. food stress during egg production more strongly affects the sex of the large than the small offspring. PMID:26089530
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Exploration of multiphoton entangled states by using weak nonlinearities
He, Ying-Qiu; Ding, Dong; Yan, Feng-Li; Gao, Ting
2016-01-01
We propose a fruitful scheme for exploring multiphoton entangled states based on linear optics and weak nonlinearities. Compared with the previous schemes the present method is more feasible because there are only small phase shifts instead of a series of related functions of photon numbers in the process of interaction with Kerr nonlinearities. In the absence of decoherence we analyze the error probabilities induced by homodyne measurement and show that the maximal error probability can be made small enough even when the number of photons is large. This implies that the present scheme is quite tractable and it is possible to produce entangled states involving a large number of photons. PMID:26751044
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Righetti, Laura; Paglia, Giuseppe; Galaverna, Gianni; Dall’Asta, Chiara
2016-01-01
Mycotoxins are secondary metabolites produced by pathogenic fungi in crops worldwide. These compounds can undergo modification in plants, leading to the formation of a large number of possible modified forms, whose toxicological relevance and occurrence in food and feed is still largely unexplored. The analysis of modified mycotoxins by liquid chromatography–mass spectrometry remains a challenge because of their chemical diversity, the large number of isomeric forms, and the lack of analytical standards. Here, the potential benefits of high-resolution and ion mobility mass spectrometry as a tool for separation and structure confirmation of modified mycotoxins have been investigated/reviewed. PMID:27918432
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Use of Item Models in a Large-Scale Admissions Test: A Case Study
ERIC Educational Resources Information Center
Sinharay, Sandip; Johnson, Matthew S.
2008-01-01
"Item models" (LaDuca, Staples, Templeton, & Holzman, 1986) are classes from which it is possible to generate items that are equivalent/isomorphic to other items from the same model (e.g., Bejar, 1996, 2002). They have the potential to produce large numbers of high-quality items at reduced cost. This article introduces data from an…
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Dwivedi, M; Shetty, K D; Nath, L Narendra
2009-01-01
An anthropometric device (AD) was designed and developed to collect data on foot and knee of locomotor disabled people. The aim was to standardize the sizes of knee-ankle-foot orthoses (KAFOs) in a standard modular form so that they can be mass produced to cater for fitting to a large number of locomotor disabled people. The anthropometric data collected on large numbers of locomotor disabled people were processed, with the help of a computer programme, to arrive at standard sizes for three modules, i.e. a foot plate (seven sizes), knee pieces (six sizes) and a lateral upright in a universal size. These modules were produced by plastic injection moulding and compression moulding processes using glass-reinforced polypropylene. KAFOs were assembled and fitted to locomotor disabled people. Feedback obtained was encouraging and this vindicated the concept, design and utility of the AD.
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Large- and small-scale constraints on power spectra in Omega = 1 universes
NASA Technical Reports Server (NTRS)
Gelb, James M.; Gradwohl, Ben-Ami; Frieman, Joshua A.
1993-01-01
The CDM model of structure formation, normalized on large scales, leads to excessive pairwise velocity dispersions on small scales. In an attempt to circumvent this problem, we study three scenarios (all with Omega = 1) with more large-scale and less small-scale power than the standard CDM model: (1) cold dark matter with significantly reduced small-scale power (inspired by models with an admixture of cold and hot dark matter); (2) cold dark matter with a non-scale-invariant power spectrum; and (3) cold dark matter with coupling of dark matter to a long-range vector field. When normalized to COBE on large scales, such models do lead to reduced velocities on small scales and they produce fewer halos compared with CDM. However, models with sufficiently low small-scale velocities apparently fail to produce an adequate number of halos.
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Challenges in Improving Cochlear Implant Performance and Accessibility.
Zeng, Fan-Gang
2017-08-01
Here I identify two gaps in cochlear implants that have been limiting their performance and acceptance. First, cochlear implant performance has remained largely unchanged, despite the number of publications tripling per decade in the last 30 years. Little has been done so far to address a fundamental limitation in the electrode-to-neuron interface, with the electrode size being a thousand times larger than the neuron diameter while the number of electrodes being a thousand times less. Both the small number and the large size of electrodes produce broad spatial activation and poor frequency resolution that limit current cochlear implant performance. Second, a similarly rapid growth in cochlear implant volume has not produced an expected decrease in unit price in the same period. The high cost contributes to low market penetration rate, which is about 20% in developed countries and less than 1% in developing countries. I will discuss changes needed in both research strategy and business practice to close the gap between prosthetic and normal hearing as well as that between haves and have-nots.
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A rapid method to increase the number of F₁ plants in pea (Pisum sativum) breeding programs.
Espósito, M A; Almirón, P; Gatti, I; Cravero, V P; Anido, F S L; Cointry, E L
2012-08-16
In breeding programs, a large number of F₂ individuals are required to perform the selection process properly, but often few such plants are available. In order to obtain more F₂ seeds, it is necessary to multiply the F₁ plants. We developed a rapid, efficient and reproducible protocol for in vitro shoot regeneration and rooting of seeds using 6-benzylaminopurine. To optimize shoot regeneration, basic medium contained Murashige and Skoog (MS) salts with or without B5 Gamborg vitamins and different concentrations of 6-benzylaminopurine (25, 50 and 75 μM) using five genotypes. We found that modified MS (B5 vitamins + 25 μM 6-benzylaminopurine) is suitable for in vitro shoot regeneration of pea. Thirty-eight hybrid combinations were transferred onto selected medium to produce shoots that were used for root induction on MS medium supplemented with α-naphthalene-acetic acid. Elongated shoots were developed from all hybrid genotypes. This procedure can be used in pea breeding programs and will allow working with a large number of plants even when the F₁ plants produce few seeds.
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NASA Technical Reports Server (NTRS)
Brown, Clarence A , Jr
1957-01-01
A full- scale rocket-powered model of a cruciform canard missile configuration with a low- aspect - ratio wing and blunt nose has been flight tested by the Langley Pilotless Aircraft Research Division. Static and dynamic longitudinal stability and control derivatives of this interdigitated canard-wing missile configuration were determined by using the pulsed- control technique at low angles of attack and for a Mach number range of 1.2 to 2.1. The lift - curve slope showed only small nonlinearities with changes in control deflection or angle of attack but indicated a difference in lift- .curve slope of approximately 7 percent for the two control deflections of delta = 3.0 deg and delta= -0.3 deg . The large tail length of the missile tested was effective in producing damping in pitch throughout the Mach number range tested. The aerodynamic- center location was nearly constant with Mach number for the two control deflections but was shown to be less stable with the larger control deflection. The increment of lift produced by the controls was small and positive throughout the Mach number range tested, whereas the pitching moment produced by the controls exhibited a normal trend of reduced effectiveness with increasing Mach number.The effectiveness of the controls in producing angle of attack, lift, and pitching moment was good at all Mach numbers tested.
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NASA Technical Reports Server (NTRS)
Brown, C. A., Jr.
1957-01-01
A full-scale rocket-powered model of a cruciform canard missile configuration with a low-aspect-ratio wing and blunt nose has been flight tested by the Langley Pilotless Aircraft Research Division. Static and dynamic longitudinal stability and control derivatives of this interdigitated canard-wing missile configuration were determined by using the pulsed-control technique at low angles of attack and for a Mach number range of 1.2 to 2.1. The lift-curve slope showed only small nonlinearities with changes in control deflection or angle of attack but indicated a difference in lift-curve slope of approximately 7 percent for the two control deflections of delta = 3.0 deg and delta = -0.3 deg. The large tail length of the missile tested was effective in producing damping in pitch throughout the Mach number range tested. The aerodynamic-center location was nearly constant with Mach number for the two control deflections but was shown to be less stable with the larger control deflection. The increment of lift produced by the controls was small and positive throughout the Mach number range tested, whereas the pitching moment produced by the controls exhibited a normal trend of reduced effectiveness with increasing Mach number. The effectiveness of the controls in producing angle of attack, lift, and pitching moment was good at all Mach numbers tested.
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Episodic, generalized, and semantic memory tests: switching and strength effects.
Humphreys, Michael S; Murray, Krista L
2011-09-01
We continue the process of investigating the probabilistic paired associate paradigm in an effort to understand the memory access control processes involved and to determine whether the memory structure produced is in transition between episodic and semantic memory. In this paradigm two targets are probabilistically paired with a cue across a large number of short lists. Participants can recall the target paired with the cue in the most recent list (list specific test), produce the first of the two targets that have been paired with that cue to come to mind (generalised test), and produce a free association response (semantic test). Switching between a generalised test and a list specific test did not produce a switching cost indicating a general similarity in the control processes involved. In addition, there was evidence for a dissociation between two different strength manipulations (amount of study time and number of cue-target pairings) such that number of pairings influenced the list specific, generalised and the semantic test but amount of study time only influenced the list specific and generalised test. © 2011 Canadian Psychological Association
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Affect in Human-Robot Interaction
2014-01-01
is capable of learning and producing a large number of facial expressions based on Ekman’s Facial Action Coding System, FACS (Ekman and Friesen 1978... tactile (pushed, stroked, etc.), auditory (loud sound), temperature and olfactory (alcohol, smoke, etc.). The personality of the robot consists of...robot’s behavior through decision-making, learning , or action selection, a number of researchers used the fuzzy logic approach to emotion generation
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Yu, Bo; Su, Fei; Wang, Limin; Xu, Ke; Zhao, Bo; Xu, Ping
2011-01-01
Sporolactobacillus inulinus CASD is an efficient d-lactic acid producer with high optical purity. Here we report for the first time the draft genome sequence of S. inulinus (2,930,096 bp). The large number of annotated two-component system genes makes it possible to explore the mechanism of extraordinary lactate tolerance of S. inulinus CASD. PMID:21952540
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Yu, Bo; Su, Fei; Wang, Limin; Xu, Ke; Zhao, Bo; Xu, Ping
2011-10-01
Sporolactobacillus inulinus CASD is an efficient D-lactic acid producer with high optical purity. Here we report for the first time the draft genome sequence of S. inulinus (2,930,096 bp). The large number of annotated two-component system genes makes it possible to explore the mechanism of extraordinary lactate tolerance of S. inulinus CASD.
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Large-scale production of lentiviral vector in a closed system hollow fiber bioreactor
Sheu, Jonathan; Beltzer, Jim; Fury, Brian; Wilczek, Katarzyna; Tobin, Steve; Falconer, Danny; Nolta, Jan; Bauer, Gerhard
2015-01-01
Lentiviral vectors are widely used in the field of gene therapy as an effective method for permanent gene delivery. While current methods of producing small scale vector batches for research purposes depend largely on culture flasks, the emergence and popularity of lentiviral vectors in translational, preclinical and clinical research has demanded their production on a much larger scale, a task that can be difficult to manage with the numbers of producer cell culture flasks required for large volumes of vector. To generate a large scale, partially closed system method for the manufacturing of clinical grade lentiviral vector suitable for the generation of induced pluripotent stem cells (iPSCs), we developed a method employing a hollow fiber bioreactor traditionally used for cell expansion. We have demonstrated the growth, transfection, and vector-producing capability of 293T producer cells in this system. Vector particle RNA titers after subsequent vector concentration yielded values comparable to lentiviral iPSC induction vector batches produced using traditional culture methods in 225 cm2 flasks (T225s) and in 10-layer cell factories (CF10s), while yielding a volume nearly 145 times larger than the yield from a T225 flask and nearly three times larger than the yield from a CF10. Employing a closed system hollow fiber bioreactor for vector production offers the possibility of manufacturing large quantities of gene therapy vector while minimizing reagent usage, equipment footprint, and open system manipulation. PMID:26151065
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Rup, B J
1989-08-15
A number of different mouse strains and immunization protocols were used to attempt to make monoclonal antibodies against rat IgE for use in studies of the structure, biological activities and regulation of this class of antibody. Successful production of large numbers of monoclonal antibodies was achieved when mast cell deficient (w/wv and sl/sld) but not conventional (BALB/c, CAF1 or SJL) mice were used. These results suggest that the poor response of conventional strains of mice to rat IgE may be due to the presence of mast cells bearing high affinity receptors for IgE in these mice.
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Quantitative Assessment of Neurite Outgrowth in PC12 Cells
In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity. In order to identify potential developmental neurotoxicants, assessment of critical neurodevelopmental processes such as neuronal differenti...
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Trojan particles: Large porous carriers of nanoparticles for drug delivery
Tsapis, N.; Bennett, D.; Jackson, B.; Weitz, D. A.; Edwards, D. A.
2002-01-01
We have combined the drug release and delivery potential of nanoparticle (NP) systems with the ease of flow, processing, and aerosolization potential of large porous particle (LPP) systems by spray drying solutions of polymeric and nonpolymeric NPs into extremely thin-walled macroscale structures. These hybrid LPPs exhibit much better flow and aerosolization properties than the NPs; yet, unlike the LPPs, which dissolve in physiological conditions to produce molecular constituents, the hybrid LPPs dissolve to produce NPs, with the drug release and delivery advantages associated with NP delivery systems. Formation of the large porous NP (LPNP) aggregates occurs via a spray-drying process that ensures the drying time of the sprayed droplet is sufficiently shorter than the characteristic time for redistribution of NPs by diffusion within the drying droplet, implying a local Peclet number much greater than unity. Additional control over LPNPs physical characteristics is achieved by adding other components to the spray-dried solutions, including sugars, lipids, polymers, and proteins. The ability to produce LPNPs appears to be largely independent of molecular component type as well as the size or chemical nature of the NPs. PMID:12200546
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Developmental Environment Effects on Sexual Selection in Male and Female Drosophila melanogaster
Morimoto, Juliano; Pizzari, Tommaso; Wigby, Stuart
2016-01-01
The developmental environment can potentially alter the adult social environment and influence traits targeted by sexual selection such as body size. In this study, we manipulated larval density in male and female Drosophila melanogaster, which results in distinct adult size phenotypes–high (low) densities for small (large) adults–and measured sexual selection in experimental groups consisting of adult males and females from high, low, or a mixture of low and high larval densities. Overall, large adult females (those reared at low larval density) had more matings, more mates and produced more offspring than small females (those reared at high larval density). The number of offspring produced by females was positively associated with their number of mates (i.e. there was a positive female Bateman gradient) in social groups where female size was experimentally varied, likely due to the covariance between female productivity and mating rate. For males, we found evidence that the larval environment affected the relative importance of sexual selection via mate number (Bateman gradients), mate productivity, paternity share, and their covariances. Mate number and mate productivity were significantly reduced for small males in social environments where males were of mixed sizes, versus social environments where all males were small, suggesting that social heterogeneity altered selection on this subset of males. Males are commonly assumed to benefit from mating with large females, but in contrast to expectations we found that in groups where both the male and female size varied, males did not gain more offspring per mating with large females. Collectively, our results indicate sex-specific effects of the developmental environment on the operation of sexual selection, via both the phenotype of individuals, and the phenotype of their competitors and mates. PMID:27167120
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Food stress causes sex-specific maternal effects in mites.
Walzer, Andreas; Schausberger, Peter
2015-08-01
Life history theory predicts that females should produce few large eggs under food stress and many small eggs when food is abundant. We tested this prediction in three female-biased size-dimorphic predatory mites feeding on herbivorous spider mite prey: Phytoseiulus persimilis, a specialized spider mite predator; Neoseiulus californicus, a generalist preferring spider mites; Amblyseius andersoni, a broad diet generalist. Irrespective of predator species and offspring sex, most females laid only one small egg under severe food stress. Irrespective of predator species, the number of female but not male eggs decreased with increasing maternal food stress. This sex-specific effect was probably due to the higher production costs of large female than small male eggs. The complexity of the response to the varying availability of spider mite prey correlated with the predators' degree of adaptation to this prey. Most A. andersoni females did not oviposit under severe food stress, whereas N. californicus and P. persimilis did oviposit. Under moderate food stress, only P. persimilis increased its investment per offspring, at the expense of egg number, and produced few large female eggs. When prey was abundant, P. persimilis decreased the female egg sizes at the expense of increased egg numbers, resulting in a sex-specific egg size/number trade-off. Maternal effects manifested only in N. californicus and P. persimilis. Small egg size correlated with the body size of daughters but not sons. Overall, our study provides a key example of sex-specific maternal effects, i.e. food stress during egg production more strongly affects the sex of the large than the small offspring. © 2015. Published by The Company of Biologists Ltd.
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An unusual variant of Trichophyton tonsurans var. sulfureum.
Padhye, A A; Weitzman, I; Domenech, E
1994-01-01
A fungus, recovered from a skin lesion of a patient, produced velvety to powdery, white to deep yellow colonies on Sabouraud glucose agar. Microscopically, it produced a large number of cylindric, smooth-walled, three- to eight-celled macroconidia but failed to produce microconidia on a variety of nutritional media such as rice grains, cornmeal dextrose, potato dextrose, Sabouraud glucose, oatmeal and lactrimel agars. It hydrolysed urea in 7 days, perforated hair in vitro and required thiamine for growth. This isolate represents an atypical variant of Trichophyton tonsurans var. sufureum subvar. perforans.
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Norris, Susan L.; Holmer, Haley K.; Burda, Brittany U.; Ogden, Lauren A.; Fu, Rongwei
2012-01-01
Background Conflict of interest (COI) of clinical practice guideline (CPG) sponsors and authors is an important potential source of bias in CPG development. The objectives of this study were to describe the COI policies for organizations currently producing a significant number of CPGs, and to determine if these policies meet 2011 Institute of Medicine (IOM) standards. Methodology/Principal Findings We identified organizations with five or more guidelines listed in the National Guideline Clearinghouse between January 1, 2009 and November 5, 2010. We obtained the COI policy for each organization from publicly accessible sources, most often the organization's website, and compared those polices to IOM standards related to COI. 37 organizations fulfilled our inclusion criteria, of which 17 (46%) had a COI policy directly related to CPGs. These COI policies varied widely with respect to types of COI addressed, from whom disclosures were collected, monetary thresholds for disclosure, approaches to management, and updating requirements. Not one organization's policy adhered to all seven of the IOM standards that were examined, and nine organizations did not meet a single one of the standards. Conclusions/Significance COI policies among organizations producing a large number of CPGs currently do not measure up to IOM standards related to COI disclosure and management. CPG developers need to make significant improvements in these policies and their implementation in order to optimize the quality and credibility of their guidelines. PMID:22629391
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Interactive Correlation Analysis and Visualization of Climate Data
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ma, Kwan-Liu
The relationship between our ability to analyze and extract insights from visualization of climate model output and the capability of the available resources to make those visualizations has reached a crisis point. The large volume of data currently produced by climate models is overwhelming the current, decades-old visualization workflow. The traditional methods for visualizing climate output also have not kept pace with changes in the types of grids used, the number of variables involved, and the number of different simulations performed with a climate model or the feature-richness of high-resolution simulations. This project has developed new and faster methods formore » visualization in order to get the most knowledge out of the new generation of high-resolution climate models. While traditional climate images will continue to be useful, there is need for new approaches to visualization and analysis of climate data if we are to gain all the insights available in ultra-large data sets produced by high-resolution model output and ensemble integrations of climate models such as those produced for the Coupled Model Intercomparison Project. Towards that end, we have developed new visualization techniques for performing correlation analysis. We have also introduced highly scalable, parallel rendering methods for visualizing large-scale 3D data. This project was done jointly with climate scientists and visualization researchers at Argonne National Laboratory and NCAR.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaboud, M.; Aad, G.; Abbott, B.
A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection then applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. In having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at √s=13 TeV, which corresponds to 36.1 fb -1 of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, wheremore » gluinos are pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaboud, M.; Aad, G.; Abbott, B.
A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. Having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at s=13 TeV, which corresponds to 36.1 fb -1 of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, where gluinos aremore » pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered.« less
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Aaboud, M.; Aad, G.; Abbott, B.; ...
2017-12-06
A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. Having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at s=13 TeV, which corresponds to 36.1 fb -1 of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, where gluinos aremore » pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered.« less
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Aaboud, M.; Aad, G.; Abbott, B.; ...
2017-12-06
A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection then applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. In having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at √s=13 TeV, which corresponds to 36.1 fb -1 of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, wheremore » gluinos are pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered.« less
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NASA Astrophysics Data System (ADS)
Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J.-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Arnaez, O.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Artoni, G.; Artz, S.; Asai, S.; Asbah, N.; Ashkenazi, A.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Augsten, K.; Avolio, G.; Axen, B.; Ayoub, M. K.; Azuelos, G.; Baas, A. E.; Baca, M. J.; Bachacou, H.; Bachas, K.; Backes, M.; Bagnaia, P.; Bahmani, M.; Bahrasemani, H.; Baines, J. T.; Bajic, M.; Baker, O. K.; Baldin, E. M.; Balek, P.; Balli, F.; Balunas, W. K.; Banas, E.; Bandyopadhyay, A.; Banerjee, Sw.; Bannoura, A. A. E.; Barak, L.; Barberio, E. L.; Barberis, D.; Barbero, M.; Barillari, T.; Barisits, M.-S.; Barkeloo, J. T.; Barklow, T.; Barlow, N.; Barnes, S. L.; Barnett, B. M.; Barnett, R. M.; Barnovska-Blenessy, Z.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barranco Navarro, L.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Bartoldus, R.; Barton, A. E.; Bartos, P.; Basalaev, A.; Bassalat, A.; Bates, R. L.; Batista, S. J.; Batley, J. R.; Battaglia, M.; Bauce, M.; Bauer, F.; Bawa, H. S.; Beacham, J. B.; Beattie, M. D.; Beau, T.; Beauchemin, P. H.; Bechtle, P.; Beck, H. P.; Beck, H. C.; Becker, K.; Becker, M.; Becot, C.; Beddall, A. J.; Beddall, A.; Bednyakov, V. A.; Bedognetti, M.; Bee, C. P.; Beermann, T. A.; Begalli, M.; Begel, M.; Behr, J. K.; Bell, A. S.; Bella, G.; Bellagamba, L.; Bellerive, A.; Bellomo, M.; Belotskiy, K.; Beltramello, O.; Belyaev, N. L.; Benary, O.; Benchekroun, D.; Bender, M.; Bendtz, K.; Benekos, N.; Benhammou, Y.; Benhar Noccioli, E.; Benitez, J.; Benjamin, D. P.; Benoit, M.; Bensinger, J. R.; Bentvelsen, S.; Beresford, L.; Beretta, M.; Berge, D.; Bergeaas Kuutmann, E.; Berger, N.; Beringer, J.; Berlendis, S.; Bernard, N. R.; Bernardi, G.; Bernius, C.; Bernlochner, F. U.; Berry, T.; Berta, P.; Bertella, C.; Bertoli, G.; Bertolucci, F.; Bertram, I. A.; Bertsche, C.; Bertsche, D.; Besjes, G. J.; Bessidskaia Bylund, O.; Bessner, M.; Besson, N.; Bethani, A.; Bethke, S.; Bevan, A. J.; Beyer, J.; Bianchi, R. M.; Biebel, O.; Biedermann, D.; Bielski, R.; Bierwagen, K.; Biesuz, N. V.; Biglietti, M.; Billoud, T. R. V.; Bilokon, H.; Bindi, M.; Bingul, A.; Bini, C.; Biondi, S.; Bisanz, T.; Bittrich, C.; Bjergaard, D. M.; Black, J. E.; Black, K. M.; Blair, R. E.; Blazek, T.; Bloch, I.; Blocker, C.; Blue, A.; Blum, W.; Blumenschein, U.; Blunier, S.; Bobbink, G. J.; Bobrovnikov, V. S.; Bocchetta, S. S.; Bocci, A.; Bock, C.; Boehler, M.; Boerner, D.; Bogavac, D.; Bogdanchikov, A. G.; Bohm, C.; Boisvert, V.; Bokan, P.; Bold, T.; Boldyrev, A. S.; Bolz, A. E.; Bomben, M.; Bona, M.; Boonekamp, M.; Borisov, A.; Borissov, G.; Bortfeldt, J.; Bortoletto, D.; Bortolotto, V.; Boscherini, D.; Bosman, M.; Bossio Sola, J. D.; Boudreau, J.; Bouffard, J.; Bouhova-Thacker, E. V.; Boumediene, D.; Bourdarios, C.; Boutle, S. K.; Boveia, A.; Boyd, J.; Boyko, I. R.; Bracinik, J.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Breaden Madden, W. D.; Brendlinger, K.; Brennan, A. J.; Brenner, L.; Brenner, R.; Bressler, S.; Briglin, D. L.; Bristow, T. M.; Britton, D.; Britzger, D.; Brochu, F. M.; Brock, I.; Brock, R.; Brooijmans, G.; Brooks, T.; Brooks, W. K.; Brosamer, J.; Brost, E.; Broughton, J. H.; Bruckman de Renstrom, P. A.; Bruncko, D.; Bruni, A.; Bruni, G.; Bruni, L. S.; Bruno, S.; Brunt, BH; Bruschi, M.; Bruscino, N.; Bryant, P.; Bryngemark, L.; Buanes, T.; Buat, Q.; Buchholz, P.; Buckley, A. G.; Budagov, I. A.; Buehrer, F.; Bugge, M. K.; Bulekov, O.; Bullock, D.; Burch, T. J.; Burdin, S.; Burgard, C. D.; Burger, A. M.; Burghgrave, B.; Burka, K.; Burke, S.; Burmeister, I.; Burr, J. T. P.; Busato, E.; Büscher, D.; Büscher, V.; Bussey, P.; Butler, J. M.; Buttar, C. M.; Butterworth, J. M.; Butti, P.; Buttinger, W.; Buzatu, A.; Buzykaev, A. R.; Cabrera Urbán, S.; Caforio, D.; Cairo, V. M.; Cakir, O.; Calace, N.; Calafiura, P.; Calandri, A.; Calderini, G.; Calfayan, P.; Callea, G.; Caloba, L. P.; Calvente Lopez, S.; Calvet, D.; Calvet, S.; Calvet, T. P.; Camacho Toro, R.; Camarda, S.; Camarri, P.; Cameron, D.; Caminal Armadans, R.; Camincher, C.; Campana, S.; Campanelli, M.; Camplani, A.; Campoverde, A.; Canale, V.; Cano Bret, M.; Cantero, J.; Cao, T.; Capeans Garrido, M. D. M.; Caprini, I.; Caprini, M.; Capua, M.; Carbone, R. M.; Cardarelli, R.; Cardillo, F.; Carli, I.; Carli, T.; Carlino, G.; Carlson, B. T.; Carminati, L.; Carney, R. M. D.; Caron, S.; Carquin, E.; Carrá, S.; Carrillo-Montoya, G. D.; Casadei, D.; Casado, M. P.; Casolino, M.; Casper, D. W.; Castelijn, R.; Castillo Gimenez, V.; Castro, N. F.; Catinaccio, A.; Catmore, J. R.; Cattai, A.; Caudron, J.; Cavaliere, V.; Cavallaro, E.; Cavalli, D.; Cavalli-Sforza, M.; Cavasinni, V.; Celebi, E.; Ceradini, F.; Cerda Alberich, L.; Cerqueira, A. S.; Cerri, A.; Cerrito, L.; Cerutti, F.; Cervelli, A.; Cetin, S. A.; Chafaq, A.; Chakraborty, D.; Chan, S. K.; Chan, W. S.; Chan, Y. L.; Chang, P.; Chapman, J. D.; Charlton, D. G.; Chau, C. C.; Chavez Barajas, C. A.; Che, S.; Cheatham, S.; Chegwidden, A.; Chekanov, S.; Chekulaev, S. V.; Chelkov, G. A.; Chelstowska, M. A.; Chen, C.; Chen, C.; Chen, H.; Chen, J.; Chen, S.; Chen, S.; Chen, X.; Chen, Y.; Cheng, H. C.; Cheng, H. 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M.; Veloso, F.; Veneziano, S.; Ventura, A.; Venturi, M.; Venturi, N.; Venturini, A.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, A. T.; Vermeulen, J. C.; Vetterli, M. C.; Viaux Maira, N.; Viazlo, O.; Vichou, I.; Vickey, T.; Vickey Boeriu, O. E.; Viehhauser, G. H. A.; Viel, S.; Vigani, L.; Villa, M.; Villaplana Perez, M.; Vilucchi, E.; Vincter, M. G.; Vinogradov, V. B.; Vishwakarma, A.; Vittori, C.; Vivarelli, I.; Vlachos, S.; Vogel, M.; Vokac, P.; Volpi, G.; von der Schmitt, H.; von Toerne, E.; Vorobel, V.; Vorobev, K.; Vos, M.; Voss, R.; Vossebeld, J. H.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vuillermet, R.; Vukotic, I.; Wagner, P.; Wagner, W.; Wagner-Kuhr, J.; Wahlberg, H.; Wahrmund, S.; Walder, J.; Walker, R.; Walkowiak, W.; Wallangen, V.; Wang, C.; Wang, C.; Wang, F.; Wang, H.; Wang, H.; Wang, J.; Wang, J.; Wang, Q.; Wang, R.; Wang, S. M.; Wang, T.; Wang, W.; Wang, W.; Wang, Z.; Wanotayaroj, C.; Warburton, A.; Ward, C. P.; Wardrope, D. R.; Washbrook, A.; Watkins, P. M.; Watson, A. T.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, B. M.; Webb, A. F.; Webb, S.; Weber, M. S.; Weber, S. W.; Weber, S. A.; Webster, J. S.; Weidberg, A. R.; Weinert, B.; Weingarten, J.; Weirich, M.; Weiser, C.; Weits, H.; Wells, P. S.; Wenaus, T.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M. D.; Werner, P.; Wessels, M.; Weston, T. D.; Whalen, K.; Whallon, N. L.; Wharton, A. M.; White, A. S.; White, A.; White, M. J.; White, R.; Whiteson, D.; Whitmore, B. W.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wiglesworth, C.; Wiik-Fuchs, L. A. M.; Wildauer, A.; Wilk, F.; Wilkens, H. G.; Williams, H. H.; Williams, S.; Willis, C.; Willocq, S.; Wilson, J. A.; Wingerter-Seez, I.; Winkels, E.; Winklmeier, F.; Winston, O. J.; Winter, B. T.; Wittgen, M.; Wobisch, M.; Wolf, T. M. H.; Wolff, R.; Wolter, M. W.; Wolters, H.; Wong, V. W. S.; Worm, S. D.; Wosiek, B. K.; Wotschack, J.; Wozniak, K. W.; Wu, M.; Wu, S. L.; Wu, X.; Wu, Y.; Wyatt, T. R.; Wynne, B. M.; Xella, S.; Xi, Z.; Xia, L.; Xu, D.; Xu, L.; Xu, T.; Yabsley, B.; Yacoob, S.; Yamaguchi, D.; Yamaguchi, Y.; Yamamoto, A.; Yamamoto, S.; Yamanaka, T.; Yamane, F.; Yamatani, M.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, H.; Yang, Y.; Yang, Z.; Yao, W.-M.; Yap, Y. C.; Yasu, Y.; Yatsenko, E.; Yau Wong, K. H.; Ye, J.; Ye, S.; Yeletskikh, I.; Yigitbasi, E.; Yildirim, E.; Yorita, K.; Yoshihara, K.; Young, C.; Young, C. J. S.; Yu, J.; Yu, J.; Yuen, S. P. Y.; Yusuff, I.; Zabinski, B.; Zacharis, G.; Zaidan, R.; Zaitsev, A. M.; Zakharchuk, N.; Zalieckas, J.; Zaman, A.; Zambito, S.; Zanzi, D.; Zeitnitz, C.; Zemaityte, G.; Zemla, A.; Zeng, J. C.; Zeng, Q.; Zenin, O.; Ženiš, T.; Zerwas, D.; Zhang, D.; Zhang, F.; Zhang, G.; Zhang, H.; Zhang, J.; Zhang, L.; Zhang, L.; Zhang, M.; Zhang, P.; Zhang, R.; Zhang, R.; Zhang, X.; Zhang, Y.; Zhang, Z.; Zhao, X.; Zhao, Y.; Zhao, Z.; Zhemchugov, A.; Zhou, B.; Zhou, C.; Zhou, L.; Zhou, M.; Zhou, M.; Zhou, N.; Zhu, C. G.; Zhu, H.; Zhu, J.; Zhu, Y.; Zhuang, X.; Zhukov, K.; Zibell, A.; Zieminska, D.; Zimine, N. I.; Zimmermann, C.; Zimmermann, S.; Zinonos, Z.; Zinser, M.; Ziolkowski, M.; Živković, L.; Zobernig, G.; Zoccoli, A.; Zou, R.; zur Nedden, M.; Zwalinski, L.
2017-12-01
A search is presented for particles that decay producing a large jet multiplicity and invisible particles. The event selection applies a veto on the presence of isolated electrons or muons and additional requirements on the number of b-tagged jets and the scalar sum of masses of large-radius jets. Having explored the full ATLAS 2015-2016 dataset of LHC proton-proton collisions at √{s}=13 TeV, which corresponds to 36.1 fb-1 of integrated luminosity, no evidence is found for physics beyond the Standard Model. The results are interpreted in the context of simplified models inspired by R-parity-conserving and R-parity-violating supersymmetry, where gluinos are pair-produced. More generic models within the phenomenological minimal supersymmetric Standard Model are also considered. [Figure not available: see fulltext.
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Branching habit and the allocation of reproductive resources in conifers.
Leslie, Andrew B
2012-09-01
Correlated relationships between branch thickness, branch density, and twig and leaf size have been used extensively to study the evolution of plant canopy architecture, but fewer studies have explored the impact of these relationships on the allocation of reproductive resources. This study quantifies pollen cone production in conifers, which have similar basic reproductive biology but vary dramatically in branching habit, in order to test how differences in branch diameter influence pollen cone size and the density with which they are deployed in the canopy. Measurements of canopy branch density, the number of cones per branch and cone size were used to estimate the amount of pollen cone tissues produced by 16 species in three major conifer clades. The number of pollen grains produced was also estimated using direct counts from individual pollen cones. The total amount of pollen cone tissues in the conifer canopy varied little among species and clades, although vegetative traits such as branch thickness, branch density and pollen cone size varied over several orders of magnitude. However, branching habit controls the way these tissues are deployed: taxa with small branches produce small pollen cones at a high density, while taxa with large branches produce large cones relatively sparsely. Conifers appear to invest similar amounts of energy in pollen production independent of branching habit. However, similar associations between branch thickness, branch density and pollen cone size are seen across conifers, including members of living and extinct groups not directly studied here. This suggests that reproductive features relating to pollen cone size are in large part a function of the evolution of vegetative morphology and branching habit.
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Jang, Mi; Shim, Won Joon; Han, Gi Myung; Song, Young Kyoung; Hong, Sang Hee
2018-06-01
Fragmentation of large plastic debris into smaller particles results in increasing microplastic concentrations in the marine environment. In plastic debris fragmentation processes, the influence of biological factors remains largely unknown. This study investigated the fragmentation of expanded polystyrene (EPS) debris by polychaetes (Marphysa sanguinea) living on the debris. A large number of EPS particles (131 ± 131 particles/individual, 0.2-3.8 mm in length) were found in the digestive tracts of burrowing polychaetes living on EPS debris. To confirm the formation of microplastics by polychaetes and identify the quantity and morphology of produced microplastics, polychaetes were exposed to EPS blocks in filtered seawater under laboratory conditions. Polychaetes burrowed into the blocks and created numerous EPS microplastic particles, indicating that a single polychaete can produce hundreds of thousands of microplastic particles per year. These results reveal the potential role of marine organisms as microplastic producers in the marine environment. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Daughters increase longevity of fathers, but daughters and sons equally reduce longevity of mothers.
Jasienska, Grazyna; Nenko, Ilona; Jasienski, Michal
2006-01-01
Reproduction is energetically and physiologically expensive, and an individual investing resources into producing offspring should suffer costs such as deterioration in health condition and possibly shorter life span. Since the energetic and nutritional demands of pregnancy and breastfeeding render reproductive costs much higher in women than in men, women with a large number of children should show signs of deterioration in condition, while men with large families should not. However, whether reproductive costs reduce longevity in women is still questionable, and in men this issue has not been adequately addressed. In addition, since sons are energetically more expensive to produce than daughters, having sons should have a more pronounced negative impact on maternal longevity than having daughters. Here we document a striking disparity in the impact of children on the life span of mothers and fathers in a Polish rural population. We show for the first time that number of daughters was positively related to a longer life span of their fathers, increasing their longevity on average by 74 weeks per daughter born, while number of sons did not have a significant effect on paternal longevity. In contrast, in women, the number of daughters and number of sons reduced maternal longevity and did so to the same extent, on average by 95 weeks per son or daughter, indicating that for women, the costs of having sons and daughters are similar.
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Assessment of Environmental Impacts of Light-Duty Vehicle Dieselization
DOT National Transportation Integrated Search
1980-06-01
This report provides a first-level assessment of the environmental effects which might result if diesel vehicles in large numbers were produced and sold, thereby changing the mix of vehicles in the in-use fleet so that a substantial fraction were die...
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Capturing haplotypes in germplasm core collections
USDA-ARS?s Scientific Manuscript database
Genomewide data sets of single nucleotide polymorphisms (SNPs) offer great potential to improve ex situ conservation. Two factors impede their use for producing core collections. First, due to the large number of SNPs, the assembly of collections that maximize diversity may be intractable using ex...
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Shiga toxins: A review of structure, mechanism, and detection
USDA-ARS?s Scientific Manuscript database
Although Shiga toxin (Stx)-producing Escherichia coli (STEC) are responsible for a minority of foodborne disease outbreaks in the United States, they account for a disproportionately large number of hospitalizations, serious sequelae, and deaths associated with foodborne illness. Diseases caused b...
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Overhead Allocation and Incentives for Cost Minimization in Defense Procurement
1992-01-01
Staff. The publication should be of interest to researchers and policymakers who are concerned about the effects of profit policy and cost - account ...ing regulations on business incentives, system costs , and contractor profits. A shorter version of this report has appeared in The Accounting Re- view... Accounting Review. ii SUMMARY Defense firms typically produce a large number of products and it is often difficult to keep track of the cost of producing
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Enhanced Cultivation Of Stimulated Murine B Cells
NASA Technical Reports Server (NTRS)
Sammons, David W.
1994-01-01
Method of in vitro cultivation of large numbers of stimulated murine B lymphocytes. Cells electrofused with other cells to produce hybridomas and monoclonal antibodies. Offers several advantages: polyclonally stimulated B-cell blasts cultivated for as long as 14 days, hybridomas created throughout culture period, yield of hybridomas increases during cultivation, and possible to expand polyclonally in vitro number of B cells specific for antigenic determinants first recognized in vivo.
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2009-06-01
capability. Mass Rearing: The ability to mass-produce large numbers of high quality insect biocontrol agents can be a tremendous asset when...implementing a biocontrol program. Common sense would dictate that releasing a high number of agents allows for higher establishment success, more rapid...varying densities of biocontrol agent (costs estimated using a constant weight). Table 1. Hypothetical calculation of Hydrellia pakistanae production cost
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Study on road surface source pollution controlled by permeable pavement
NASA Astrophysics Data System (ADS)
Zheng, Chaocheng
2018-06-01
The increase of impermeable pavement in urban construction not only increases the runoff of the pavement, but also produces a large number of Non-Point Source Pollution. In the process of controlling road surface runoff by permeable pavement, a large number of particulate matter will be withheld when rainwater is being infiltrated, so as to control the source pollution at the source. In this experiment, we determined the effect of permeable road surface to remove heavy pollutants in the laboratory and discussed the related factors that affect the non-point pollution of permeable pavement, so as to provide a theoretical basis for the application of permeable pavement.
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Acrolein Microspheres Are Bonded To Large-Area Substrates
NASA Technical Reports Server (NTRS)
Rembaum, Alan; Yen, Richard C. K.
1988-01-01
Reactive cross-linked microspheres produced under influence of ionizing radiation in aqueous solutions of unsaturated aldehydes, such as acrolein, with sodium dodecyl sulfate. Diameters of spheres depend on concentrations of ingredients. If polystyrene, polymethylmethacrylate, or polypropylene object immersed in solution during irradiation, microspheres become attached to surface. Resulting modified surface has grainy coating with reactivity similar to free microspheres. Aldehyde-substituted-functional microspheres react under mild conditions with number of organic reagents and with most proteins. Microsphere-coated macrospheres or films used to immobilize high concentrations of proteins, enzymes, hormones, viruses, cells, and large number of organic compounds. Applications include separation techniques, clinical diagnostic tests, catalytic processes, and battery separators.
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IS SOLAR CYCLE 24 PRODUCING MORE CORONAL MASS EJECTIONS THAN CYCLE 23?
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wang, Y.-M.; Colaninno, R., E-mail: yi.wang@nrl.navy.mil, E-mail: robin.colaninno@nrl.navy.mil
2014-04-01
Although sunspot numbers are roughly a factor of two lower in the current cycle than in cycle 23, the rate of coronal mass ejections (CMEs) appears to be at least as high in 2011-2013 as during the corresponding phase of the previous cycle, according to three catalogs that list events observed with the Large Angle and Spectrometric Coronagraph (LASCO). However, the number of CMEs detected is sensitive to such factors as the image cadence and the tendency (especially by human observers) to under-/overcount small or faint ejections during periods of high/low activity. In contrast to the total number, the totalmore » mass of CMEs is determined mainly by larger events. Using the mass measurements of 11,000 CMEs given in the manual CDAW catalog, we find that the mass loss rate remains well correlated with the sunspot number during cycle 24. In the case of the automated CACTus and SEEDS catalogs, the large increase in the number of CMEs during cycle 24 is almost certainly an artifact caused by the near-doubling of the LASCO image cadence after mid-2010. We confirm that fast CMEs undergo a much stronger solar-cycle variation than slow ones, and that the relative frequency of slow and less massive CMEs increases with decreasing sunspot number. We conclude that cycle 24 is not only producing fewer CMEs than cycle 23, but that these ejections also tend to be slower and less massive than those observed one cycle earlier.« less
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Screening large-scale association study data: exploiting interactions using random forests.
Lunetta, Kathryn L; Hayward, L Brooke; Segal, Jonathan; Van Eerdewegh, Paul
2004-12-10
Genome-wide association studies for complex diseases will produce genotypes on hundreds of thousands of single nucleotide polymorphisms (SNPs). A logical first approach to dealing with massive numbers of SNPs is to use some test to screen the SNPs, retaining only those that meet some criterion for further study. For example, SNPs can be ranked by p-value, and those with the lowest p-values retained. When SNPs have large interaction effects but small marginal effects in a population, they are unlikely to be retained when univariate tests are used for screening. However, model-based screens that pre-specify interactions are impractical for data sets with thousands of SNPs. Random forest analysis is an alternative method that produces a single measure of importance for each predictor variable that takes into account interactions among variables without requiring model specification. Interactions increase the importance for the individual interacting variables, making them more likely to be given high importance relative to other variables. We test the performance of random forests as a screening procedure to identify small numbers of risk-associated SNPs from among large numbers of unassociated SNPs using complex disease models with up to 32 loci, incorporating both genetic heterogeneity and multi-locus interaction. Keeping other factors constant, if risk SNPs interact, the random forest importance measure significantly outperforms the Fisher Exact test as a screening tool. As the number of interacting SNPs increases, the improvement in performance of random forest analysis relative to Fisher Exact test for screening also increases. Random forests perform similarly to the univariate Fisher Exact test as a screening tool when SNPs in the analysis do not interact. In the context of large-scale genetic association studies where unknown interactions exist among true risk-associated SNPs or SNPs and environmental covariates, screening SNPs using random forest analyses can significantly reduce the number of SNPs that need to be retained for further study compared to standard univariate screening methods.
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NASA Astrophysics Data System (ADS)
Bridel-Bertomeu, Thibault; Gicquel, L. Y. M.; Staffelbach, G.
2017-06-01
Rotating cavity flows are essential components of industrial applications but their dynamics are still not fully understood when it comes to the relation between the fluid organization and monitored pressure fluctuations. From computer hard-drives to turbo-pumps of space launchers, designed devices often produce flow oscillations that can either destroy the component prematurely or produce too much noise. In such a context, large scale dynamics of high Reynolds number rotor/stator cavities need better understanding especially at the flow limit-cycle or associated statistically stationary state. In particular, the influence of curvature as well as cavity aspect ratio on the large scale organization and flow stability at a fixed rotating disc Reynolds number is fundamental. To probe such flows, wall-resolved large eddy simulation is applied to two different rotor/stator cylindrical cavities and one annular cavity. Validation of the predictions proves the method to be suited and to capture the disc boundary layer patterns reported in the literature. It is then shown that in complement to these disc boundary layer analyses, at the limit-cycle the rotating flows exhibit characteristic patterns at mid-height in the homogeneous core pointing the importance of large scale features. Indeed, dynamic modal decomposition reveals that the entire flow dynamics are driven by only a handful of atomic modes whose combination links the oscillatory patterns observed in the boundary layers as well as in the core of the cavity. These fluctuations form macro-structures, born in the unstable stator boundary layer and extending through the homogeneous inviscid core to the rotating disc boundary layer, causing its instability under some conditions. More importantly, the macro-structures significantly differ depending on the configuration pointing the need for deeper understanding of the influence of geometrical parameters as well as operating conditions.
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Zaehringer, Julie G; Wambugu, Grace; Kiteme, Boniface; Eckert, Sandra
2018-05-01
Africa has been heavily targeted by large-scale agricultural investments (LAIs) throughout the last decade, with scarcely known impacts on local social-ecological systems. In Kenya, a large number of LAIs were made in the region northwest of Mount Kenya. These large-scale farms produce vegetables and flowers mainly for European markets. However, land use in the region remains dominated by small-scale crop and livestock farms with less than 1 ha of land each, who produce both for their own subsistence and for the local markets. We interviewed 100 small-scale farmers living near five different LAIs to elicit their perceptions of the impacts that these LAIs have on their land use and the overall environment. Furthermore, we analyzed remotely sensed land cover and land use data to assess land use change in the vicinity of the five LAIs. While land use change did not follow a clear trend, a number of small-scale farmers did adapt their crop management to environmental changes such as a reduced river water flows and increased pests, which they attributed to the presence of LAIs. Despite the high number of open conflicts between small-scale land users and LAIs around the issue of river water abstraction, the main environmental impact, felt by almost half of the interviewed land users, was air pollution with agrochemicals sprayed on the LAIs' land. Even though only a low percentage of local land users and their household members were directly involved with LAIs, a large majority of respondents favored the presence of LAIs nearby, as they are believed to contribute to the region's overall economic development. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Neuronal models for evaluation of proliferation in vitro using high content screening
In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity (hazard identification). In order to identify potential developmental neurotoxicants, a battery of in vitro tests for neurodevelopmental proc...
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TECHNICAL CHALLENGES ASSOCIATED WITH ASSESSING THE IN VITRO PULMONARY TOXICITY OF CARBON NANOTUBES
Nanotechnology continues to produce a large number of diverse engineered nanomaterials (NMs) with novel physicochemical properties for a variety of applications. Test methods that accurately assess/predict the toxicity of NMs are critically needed and it is unclear whether curren...
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ERIC Educational Resources Information Center
Michael, Greg
2001-01-01
Describes computed tomography (CT), a medical imaging technique that produces images of transaxial planes through the human body. A CT image is reconstructed mathematically from a large number of one-dimensional projections of a plane. The technique is used in radiological examinations and radiotherapy treatment planning. (Author/MM)
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ERIC Educational Resources Information Center
Lundegård, Iann
2015-01-01
Today an increasing number of countries around the world have acquired almost the same metaphorical speech about teaching and learning. These theories grown in the Western world are largely produced within the framework of psychology and individualistic oriented educational philosophy and fits with the ever-expanding financial growth paradigm.…
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NASA Astrophysics Data System (ADS)
Petrila, S.; Brabie, G.; Chirita, B.
2016-08-01
The analysis performed on manufacturing flows within industrial enterprises producing hydrostatic components twos made on a number of factors that influence smooth running of production such: distance between pieces, waiting time from one surgery to another; time achievement of setups on CNC machines; tool changing in case of a large number of operators and manufacturing complexity of large files [2]. To optimize the manufacturing flow it was used the software Tecnomatix. This software represents a complete portfolio of manufacturing solutions digital manufactured by Siemens. It provides innovation by linking all production methods of a product from process design, process simulation, validation and ending the manufacturing process. Among its many capabilities to create a wide range of simulations, the program offers various demonstrations regarding the behavior manufacturing cycles. This program allows the simulation and optimization of production systems and processes in several areas such as: car suppliers, production of industrial equipment; electronics manufacturing, design and production of aerospace and defense parts.
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Van Loveren, H; Osterhaus, A D; Nagel, J; Schuurman, H J; Vos, J G
1988-09-01
This report describes procedures to quantify IgA responses in the rat sensitized to ovalbumin or infected with the parasite Trichinella spiralis: an ELISPOT detecting specific IgA antibody-producing cells in lymph nodes, and an ELISA demonstrating IgA antibody in serum and gut mucosal scrapings. For this purpose a mouse monoclonal anti-rat IgA antibody was produced. This IgG1-kappa 1 antibody recognized rat IgA but not rat IgM, IgG, or IgE. It proved very suitable in both assays. Using this reagent we could demonstrate large numbers of IgA anti-ovalbumin-producing cells in the mesenteric lymph nodes 15 days after sensitization to ovalbumin via the Peyer's patches. At 28 days after sensitization the numbers were much lower. IgA antibody titres to ovalbumin in serum were maximal between days 14 and 21 after immunization. Maximal numbers of IgA anti-T. spiralis-producing cells were found in the mesenteric lymph nodes 12 days after infection with muscle larvae, followed by a sharp decrease at 15 days. Maximal IgA anti-T. spiralis antibody titres in serum and mucus scrapings of small intestines were found on days 10 and 12 after oral infection with the parasite.
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Cost effective technologies and renewable substrates for biosurfactants’ production
Banat, Ibrahim M.; Satpute, Surekha K.; Cameotra, Swaranjit S.; Patil, Rajendra; Nyayanit, Narendra V.
2014-01-01
Diverse types of microbial surface active amphiphilic molecules are produced by a range of microbial communities. The extraordinary properties of biosurfactant/bioemulsifier (BS/BE) as surface active products allows them to have key roles in various field of applications such as bioremediation, biodegradation, enhanced oil recovery, pharmaceutics, food processing among many others. This leads to a vast number of potential applications of these BS/BE in different industrial sectors. Despite the huge number of reports and patents describing BS and BE applications and advantages, commercialization of these compounds remain difficult, costly and to a large extent irregular. This is mainly due to the usage of chemically synthesized media for growing producing microorganism and in turn the production of preferred quality products. It is important to note that although a number of developments have taken place in the field of BS industries, large scale production remains economically challenging for many types of these products. This is mainly due to the huge monetary difference between the investment and achievable productivity from the commercial point of view. This review discusses low cost, renewable raw substrates, and fermentation technology in BS/BE production processes and their role in reducing the production cost. PMID:25566213
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Nogueira, Carlos E Sampaio; Ruggiero, Jose R; Sist, Paola; Cescutti, Paola; Urbani, Ranieri; Rizzo, Roberto
2005-04-11
Conformational energy calculations and molecular dynamics investigations, both in water and in dimethyl sulfoxide, were carried out on the exopolysaccharide cepacian produced by the majority of the clinical strains of Burkholderia cepacia, an opportunistic pathogen causing serious lung infection in patients affected by cystic fibrosis, The investigation was aimed at defining the structural and conformational features, which might be relevant for clarification of the structure-function relationships of the polymer. The molecular dynamics calculations were carried out by Ramachandran-type energy plots of the disaccharides that constitute the polymer repeating unit. The dynamics of an oligomer composed of three repeating units were investigated in water and in Me2SO, a non-aggregating solvent. Analysis of the time persistence of hydrogen bonds showed the presence of a large number of favourable interactions in water, which were less evident in Me2SO. The calculations on the cepacian chain indicated that polymer conformational features in water were affected by the lateral chains, but were also largely dictated by the presence of solvent. Moreover, the large number of intra-chain hydrogen bonds in water disappeared in Me2SO solution, increasing the average dimension of the polymer chains.
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Amplified emission and lasing in a plasmonic nanolaser with many three-level molecules
NASA Astrophysics Data System (ADS)
Zhang, Yuan; Mølmer, Klaus
2018-01-01
Steady-state plasmonic lasing is studied theoretically for a system consisting of many dye molecules arranged regularly around a gold nanosphere. A three-level model with realistic molecular dissipation is employed to analyze the performance as a function of the pump field amplitude and number of molecules. Few molecules and moderate pumping produce a single narrow emission peak because the excited molecules transfer energy to a single dipole plasmon mode by amplified spontaneous emission. Under strong pumping, the single peak splits into broader and weaker emission peaks because two molecular excited levels interfere with each other through coherent coupling with the pump field and with the dipole plasmon field. A large number of molecules gives rise to a Poisson-like distribution of plasmon number states with a large mean number characteristic of lasing action. These characteristics of lasing, however, deteriorate under strong pumping because of the molecular interference effect.
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Real-time fast physical random number generator with a photonic integrated circuit.
Ugajin, Kazusa; Terashima, Yuta; Iwakawa, Kento; Uchida, Atsushi; Harayama, Takahisa; Yoshimura, Kazuyuki; Inubushi, Masanobu
2017-03-20
Random number generators are essential for applications in information security and numerical simulations. Most optical-chaos-based random number generators produce random bit sequences by offline post-processing with large optical components. We demonstrate a real-time hardware implementation of a fast physical random number generator with a photonic integrated circuit and a field programmable gate array (FPGA) electronic board. We generate 1-Tbit random bit sequences and evaluate their statistical randomness using NIST Special Publication 800-22 and TestU01. All of the BigCrush tests in TestU01 are passed using 410-Gbit random bit sequences. A maximum real-time generation rate of 21.1 Gb/s is achieved for random bit sequences in binary format stored in a computer, which can be directly used for applications involving secret keys in cryptography and random seeds in large-scale numerical simulations.
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Abd El Razak, Ahmed; Ward, Alan C; Glassey, Jarka
2014-02-01
Water samples from three different environments including Mid Atlantic Ridge, Red Sea and Mediterranean Sea were screened in order to isolate new polyunsaturated fatty acids (PUFAs) bacterial producers especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Two hundred and fifty-one isolates were screened for PUFA production and among them the highest number of producers was isolated from the Mid-Atlantic Ridge followed by the Red Sea while no producers were found in the Mediterranean Sea samples. The screening strategy included a simple colourimetric method followed by a confirmation via GC/MS. Among the tested producers, an isolate named 66 was found to be a potentially high PUFA producer producing relatively high levels of EPA in particular. A Plackett-Burman statistical design of experiments was applied to screen a wide number of media components identifying glycerol and whey as components of a production medium. The potential low-cost production medium was optimised by applying a response surface methodology to obtain the highest productivity converting industrial by-products into value-added products. The maximum achieved productivity of EPA was 20 mg/g, 45 mg/l, representing 11% of the total fatty acids, which is approximately five times more than the amount produced prior to optimisation. The production medium composition was 10.79 g/l whey and 6.87 g/l glycerol. To our knowledge, this is the first investigation of potential bacteria PUFA producers from Mediterranean and Red Seas providing an evaluation of a colourimetric screening method as means of rapid screening of a large number of isolates.
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Designing a multiroute synthesis scheme in combinatorial chemistry.
Akavia, Adi; Senderowitz, Hanoch; Lerner, Alon; Shamir, Ron
2004-01-01
Solid-phase mix-and-split combinatorial synthesis is often used to produce large arrays of compounds to be tested during the various stages of the drug development process. This method can be represented by a synthesis graph in which nodes correspond to grow operations and arcs to beads transferred among the different reaction vessels. In this work, we address the problem of designing such a graph which maximizes the number of produced target compounds (namely, compounds out of an input library of desired molecules), given constraints on the number of beads used for library synthesis and on the number of reaction vessels available for concurrent grow steps. We present a heuristic based on a discrete search for solving this problem, test our solution on several data sets, explore its behavior, and show that it achieves good performance.
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Aplication of giberelins on flowering and yield of two varieties of shallot in lowland
NASA Astrophysics Data System (ADS)
Triharyanto, E.; Nyoto, S.; Yusrifani, I.
2018-03-01
Shallot is one of horticultural commodities which has difficulties in flowering and producing seeds. Flowering of shallot generally occurs in highlands at 9-12° C. Flowering in lowland can be supported with vernalization or replace cold temperature with gibberelin (GA3). This research is aimed to determine the effect of varieties, the concentration of GA3 applied and their interaction on flowering and yield of shallots grown in the lowlands, 98 m altitude with Vertisol-type soil. The research was conducted in a randomized complete block design (RCBD) with two factors, which were varieties (V): Bima and Mentes and concentration of GA3 (C) 0 ppm, 50 ppm, 100 ppm, 150 ppm and 200 ppm and repeated three times. Varieties have significant effect (P<0.05) on plant height, leaf number, the number of bulbs per clumps, weight of fresh bulbs per clumps, and percentage of small and large bulbs produced. Bima varieties were able to flower and produced seeds, while Mentes varieties could not produce flowers and seeds. GA3 concentration have no significant effect in all of the observed component. GA3 can’t replace cold temperature for supported flowering in varieties Mentes which were planted in lowlands. There was interaction between varieties and GA3 concentration occurs in variable percentage of small and large bulbs.
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Tresadern, Gary; Agrafiotis, Dimitris K
2009-12-01
Stochastic proximity embedding (SPE) and self-organizing superimposition (SOS) are two recently introduced methods for conformational sampling that have shown great promise in several application domains. Our previous validation studies aimed at exploring the limits of these methods and have involved rather exhaustive conformational searches producing a large number of conformations. However, from a practical point of view, such searches have become the exception rather than the norm. The increasing popularity of virtual screening has created a need for 3D conformational search methods that produce meaningful answers in a relatively short period of time and work effectively on a large scale. In this work, we examine the performance of these algorithms and the effects of different parameter settings at varying levels of sampling. Our goal is to identify search protocols that can produce a diverse set of chemically sensible conformations and have a reasonable probability of sampling biologically active space within a small number of trials. Our results suggest that both SPE and SOS are extremely competitive in this regard and produce very satisfactory results with as few as 500 conformations per molecule. The results improve even further when the raw conformations are minimized with a molecular mechanics force field to remove minor imperfections and any residual strain. These findings provide additional evidence that these methods are suitable for many everyday modeling tasks, both high- and low-throughput.
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Measurement of High Reynolds Number Stratified Turbulent Wake of a Towed Sphere
NASA Astrophysics Data System (ADS)
Brandt, Alan; Kalumuck, Kenneth
2017-11-01
Although aircraft and ships operate at Reynolds numbers significantly greater than one million, there are virtually no extant data on the turbulence of wakes at Re >106, above the drag crisis regime. The present study is designed to characterize the near-field of a stratified wake at large Reynolds numbers, Re 2 x 105 - 106, by towing a large diameter (D 0.5 m) sphere through a thermally stratified fresh water lake and a thermally stratified large salt water towing tank. Stratification produced BV frequencies, N, up to 0.07 s-1 resulting in Froude numbers F = U/ND >= 15. Three component turbulent velocities and temperature measurements were obtained using Acoustic Doppler Velocimeters (ADVs) and an array of fast response thermistors at various downstream distances. Turbulence power spectra of both the velocity and temperature signals exhibited a clear -5/3 slope over an order-of-magnitude range in wavenumber, which is generally not clearly evident in lower Re laboratory experiments. This study is sponsored by the Office of Naval Research Turbulence and Stratified Wakes Program.
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On decentralized control of large-scale systems
NASA Technical Reports Server (NTRS)
Siljak, D. D.
1978-01-01
A scheme is presented for decentralized control of large-scale linear systems which are composed of a number of interconnected subsystems. By ignoring the interconnections, local feedback controls are chosen to optimize each decoupled subsystem. Conditions are provided to establish compatibility of the individual local controllers and achieve stability of the overall system. Besides computational simplifications, the scheme is attractive because of its structural features and the fact that it produces a robust decentralized regulator for large dynamic systems, which can tolerate a wide range of nonlinearities and perturbations among the subsystems.
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Marine actinobacteria: an important source of bioactive natural products.
Manivasagan, Panchanathan; Kang, Kyong-Hwa; Sivakumar, Kannan; Li-Chan, Eunice C Y; Oh, Hyun-Myung; Kim, Se-Kwon
2014-07-01
Marine environment is largely an untapped source for deriving actinobacteria, having potential to produce novel, bioactive natural products. Actinobacteria are the prolific producers of pharmaceutically active secondary metabolites, accounting for about 70% of the naturally derived compounds that are currently in clinical use. Among the various actinobacterial genera, Actinomadura, Actinoplanes, Amycolatopsis, Marinispora, Micromonospora, Nocardiopsis, Saccharopolyspora, Salinispora, Streptomyces and Verrucosispora are the major potential producers of commercially important bioactive natural products. In this respect, Streptomyces ranks first with a large number of bioactive natural products. Marine actinobacteria are unique enhancing quite different biological properties including antimicrobial, anticancer, antiviral, insecticidal and enzyme inhibitory activities. They have attracted global in the last ten years for their ability to produce pharmaceutically active compounds. In this review, we have focused attention on the bioactive natural products isolated from marine actinobacteria, possessing unique chemical structures that may form the basis for synthesis of novel drugs that could be used to combat resistant pathogenic microorganisms. Copyright © 2014 Elsevier B.V. All rights reserved.
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In vitro models may be useful for the rapid toxicological screening of large numbers of chemicals for their potential to produce toxicity. Such screening could facilitate prioritization of resources needed for in vivo toxicity testing towards those chemicals most likely to resul...
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Automated Simultaneous Assembly for Multistage Testing
ERIC Educational Resources Information Center
Breithaupt, Krista; Ariel, Adelaide; Veldkamp, Bernard P.
2005-01-01
This article offers some solutions used in the assembly of the computerized Uniform Certified Public Accountancy (CPA) licensing examination as practical alternatives for operational programs producing large numbers of forms. The Uniform CPA examination was offered as an adaptive multistage test (MST) beginning in April of 2004. Examples of…
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Experimental Studies on Hypersonic Stagnation Point Chemical Environment
2006-02-01
conditions [60]. Having this complete definition we will focus on the chemical environment produce in the SPR. 3.2 Chemical environment evaluation Flow ... chemistry involves a very large number of processes and microscopic phenomena, they are usually summarized in a set of chemical reactions, with their own
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Phytosanitary irradiation and fresh fruit quality: Cultivar and maturity effects
USDA-ARS?s Scientific Manuscript database
Irradiation is an effective quarantine treatment for global trade of fresh produce. Variation in cultivars and maturity stages can impact the tolerance of fresh fruits to irradiation for the purposes of quarantine security. Tolerance thresholds for irradiated fruit are lacking for a large number of ...
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NASA Astrophysics Data System (ADS)
Vollmer, D. R.; McHarg, M. G.; Harley, J.; Haaland, R. K.; Stenbaek-Nielsen, H.
2016-12-01
On 23 July 2014, a mesoscale convective event over western Nebraska produced a large number of sprites. One frame per second images obtained from a low-noise Andor Scientific CMOS camera showed regularly-spaced horizontal striations in the airglow both before and during several of the sprite events, suggesting the presence of vertically-propagating gravity waves in the middle atmosphere. Previous work hypothesized that the gravity waves were produced by the thunderstorm itself. We compare our observations with previous work, and present numerical simulations conducted to determine source, structure, and propagation of atmospheric gravity waves.
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Rare variants and cardiovascular disease.
Wain, Louise V
2014-09-01
Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the Western world. Large genome-wide association studies (GWASs) of coronary artery disease, myocardial infarction, stroke and dilated cardiomyopathy have identified a number of common genetic variants with modest effects on disease risk. Similarly, studies of important modifiable risk factors of CVD have identified a large number of predominantly common variant associations, for example, with blood pressure and blood lipid levels. In each case, despite the often large numbers of loci identified, only a small proportion of the phenotypic variance is explained. It has been hypothesised that rare variants with large effects may account for some of the missing variance but large-scale studies of rare variation are in their infancy for cardiovascular traits and have yet to produce fruitful results. Studies of monogenic CVDs, inherited disorders believed to be entirely driven by individual rare mutations, have highlighted genes that play a key role in disease aetiology. In this review, we discuss how findings from studies of rare variants in monogenic disease and GWAS of predominantly common variants are converging to provide further insight into biological disease mechanisms. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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Highly Efficient Large-Scale Lentiviral Vector Concentration by Tandem Tangential Flow Filtration
Cooper, Aaron R.; Patel, Sanjeet; Senadheera, Shantha; Plath, Kathrin; Kohn, Donald B.; Hollis, Roger P.
2014-01-01
Large-scale lentiviral vector (LV) concentration can be inefficient and time consuming, often involving multiple rounds of filtration and centrifugation. This report describes a simpler method using two tangential flow filtration (TFF) steps to concentrate liter-scale volumes of LV supernatant, achieving in excess of 2000-fold concentration in less than 3 hours with very high recovery (>97%). Large volumes of LV supernatant can be produced easily through the use of multi-layer flasks, each having 1720 cm2 surface area and producing ~560 mL of supernatant per flask. Combining the use of such flasks and TFF greatly simplifies large-scale production of LV. As a demonstration, the method is used to produce a very high titer LV (>1010 TU/mL) and transduce primary human CD34+ hematopoietic stem/progenitor cells at high final vector concentrations with no overt toxicity. A complex LV (STEMCCA) for induced pluripotent stem cell generation is also concentrated from low initial titer and used to transduce and reprogram primary human fibroblasts with no overt toxicity. Additionally, a generalized and simple multiplexed real- time PCR assay is described for lentiviral vector titer and copy number determination. PMID:21784103
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NASA Astrophysics Data System (ADS)
Brey, Steven J.; Ruminski, Mark; Atwood, Samuel A.; Fischer, Emily V.
2018-02-01
Fires represent an air quality challenge because they are large, dynamic and transient sources of particulate matter and ozone precursors. Transported smoke can deteriorate air quality over large regions. Fire severity and frequency are likely to increase in the future, exacerbating an existing problem. Using the National Environmental Satellite, Data, and Information Service (NESDIS) Hazard Mapping System (HMS) smoke data for North America for the period 2007 to 2014, we examine a subset of fires that are confirmed to have produced sufficient smoke to warrant the initiation of a U.S. National Weather Service smoke forecast. We find that gridded HMS-analyzed fires are well correlated (r = 0.84) with emissions from the Global Fire Emissions Inventory Database 4s (GFED4s). We define a new metric, smoke hours, by linking observed smoke plumes to active fires using ensembles of forward trajectories. This work shows that the Southwest, Northwest, and Northwest Territories initiate the most air quality forecasts and produce more smoke than any other North American region by measure of the number of HYSPLIT points analyzed, the duration of those HYSPLIT points, and the total number of smoke hours produced. The average number of days with smoke plumes overhead is largest over the north-central United States. Only Alaska, the Northwest, the Southwest, and Southeast United States regions produce the majority of smoke plumes observed over their own borders. This work moves a new dataset from a daily operational setting to a research context, and it demonstrates how changes to the frequency or intensity of fires in the western United States could impact other regions.
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Complete in vitro oogenesis: retrospects and prospects.
Wang, Jun-Jie; Ge, Wei; Liu, Jing-Cai; Klinger, Francesca Gioia; Dyce, Paul W; De Felici, Massimo; Shen, Wei
2017-11-01
Precise control of mammalian oogenesis has been a traditional focus of reproductive and developmental biology research. Recently, new reports have introduced the possibility of obtaining functional gametes derived in vitro from stem cells. The potential to produce functional gametes from stem cells has exciting applications for regenerative medicine though still remains challenging. In mammalian females ovulation and fertilization is a privilege reserved for a small number of oocytes. In reality the vast majority of oocytes formed from primordial germ cells (PGCs) will undergo apoptosis, or other forms of cell death. Removal occurs during germ cell cyst breakdown and the establishment of the primordial follicle (PF) pool, during the long dormancy at the PF stage, or through follicular atresia prior to reaching the ovulatory stage. A way to solve this limitation could be to produce large numbers of oocytes, in vitro, from stem cells. However, to recapitulate mammalian oogenesis and produce fertilizable oocytes in vitro is a complex process involving several different cell types, precise follicular cell-oocyte reciprocal interactions, a variety of nutrients and combinations of cytokines, and precise growth factors and hormones depending on the developmental stage. In 2016, two papers published by Morohaku et al. and Hikabe et al. reported in vitro procedures that appear to reproduce efficiently these conditions allowing for the production, completely in a dish, of a relatively large number of oocytes that are fertilizable and capable of giving rise to viable offspring in the mouse. The present article offers a critical overview of these results as well as other previous work performed mainly in mouse attempting to reproduce oogenesis completely in vitro and considers some perspectives for the potential to adapt the methods to produce functional human oocytes.
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Branching habit and the allocation of reproductive resources in conifers
Leslie, Andrew B.
2012-01-01
Background and Aims Correlated relationships between branch thickness, branch density, and twig and leaf size have been used extensively to study the evolution of plant canopy architecture, but fewer studies have explored the impact of these relationships on the allocation of reproductive resources. This study quantifies pollen cone production in conifers, which have similar basic reproductive biology but vary dramatically in branching habit, in order to test how differences in branch diameter influence pollen cone size and the density with which they are deployed in the canopy. Methods Measurements of canopy branch density, the number of cones per branch and cone size were used to estimate the amount of pollen cone tissues produced by 16 species in three major conifer clades. The number of pollen grains produced was also estimated using direct counts from individual pollen cones. Key Results The total amount of pollen cone tissues in the conifer canopy varied little among species and clades, although vegetative traits such as branch thickness, branch density and pollen cone size varied over several orders of magnitude. However, branching habit controls the way these tissues are deployed: taxa with small branches produce small pollen cones at a high density, while taxa with large branches produce large cones relatively sparsely. Conclusions Conifers appear to invest similar amounts of energy in pollen production independent of branching habit. However, similar associations between branch thickness, branch density and pollen cone size are seen across conifers, including members of living and extinct groups not directly studied here. This suggests that reproductive features relating to pollen cone size are in large part a function of the evolution of vegetative morphology and branching habit. PMID:22782240
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NASA Technical Reports Server (NTRS)
Bernhardt, Paul A.; Scales, W. A.
1990-01-01
Ionospheric plasma density irregularities can be produced by chemical releases into the upper atmosphere. F-region plasma modification occurs by: (1) chemically enhancing the electron number density; (2) chemically reducing the electron population; or (3) physically convecting the plasma from one region to another. The three processes (production, loss, and transport) determine the effectiveness of ionospheric chemical releases in subtle and surprising ways. Initially, a chemical release produces a localized change in plasma density. Subsequent processes, however, can lead to enhanced transport in chemically modified regions. Ionospheric modifications by chemical releases excites artificial enhancements in airglow intensities by exothermic chemical reactions between the newly created plasma species. Numerical models were developed to describe the creation and evolution of large scale density irregularities and airglow clouds generated by artificial means. Experimental data compares favorably with theses models. It was found that chemical releases produce transient, large amplitude perturbations in electron density which can evolve into fine scale irregularities via nonlinear transport properties.
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Low Pressure Seeder Development for PIV in Large Scale Open Loop Wind Tunnels
NASA Astrophysics Data System (ADS)
Schmit, Ryan
2010-11-01
A low pressure seeding techniques have been developed for Particle Image Velocimetry (PIV) in large scale wind tunnel facilities was performed at the Subsonic Aerodynamic Research Laboratory (SARL) facility at Wright-Patterson Air Force Base. The SARL facility is an open loop tunnel with a 7 by 10 foot octagonal test section that has 56% optical access and the Mach number varies from 0.2 to 0.5. A low pressure seeder sprayer was designed and tested in the inlet of the wind tunnel. The seeder sprayer was designed to produce an even and uniform distribution of seed while reducing the seeders influence in the test section. ViCount Compact 5000 using Smoke Oil 180 was using as the seeding material. The results show that this low pressure seeder does produce streaky seeding but excellent PIV images are produced.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Schell, Daniel J
The goal of this work is to use the large fermentation vessels in the National Renewable Energy Laboratory's (NREL) Integrated Biorefinery Research Facility (IBRF) to scale-up Lygos' biological-based process for producing malonic acid and to generate performance data. Initially, work at the 1 L scale validated successful transfer of Lygos' fermentation protocols to NREL using a glucose substrate. Outside of the scope of the CRADA with NREL, Lygos tested their process on lignocellulosic sugars produced by NREL at Lawrence Berkeley National Laboratory's (LBNL) Advanced Biofuels Process Development Unit (ABPDU). NREL produced these cellulosic sugar solutions from corn stover using amore » separate cellulose/hemicellulose process configuration. Finally, NREL performed fermentations using glucose in large fermentors (1,500- and 9,000-L vessels) to intermediate product and to demonstrate successful performance of Lygos' technology at larger scales.« less
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Mazzitelli, S; Tosi, A; Balestra, C; Nastruzzi, C; Luca, G; Mancuso, F; Calafiore, R; Calvitti, M
2008-09-01
The optimization, through a Design of Experiments (DoE) approach, of a microencapsulation procedure for isolated neonatal porcine islets (NPI) is described. The applied method is based on the generation of monodisperse droplets by a vibrational nozzle. An alginate/polyornithine encapsulation procedure, developed and validated in our laboratory for almost a decade, was used to embody pancreatic islets. We analyzed different experimental parameters including frequency of vibration, amplitude of vibration, polymer pumping rate, and distance between the nozzle and the gelling bath. We produced calcium-alginate gel microbeads with excellent morphological characteristics as well as a very narrow size distribution. The automatically produced microcapsules did not alter morphology, viability and functional properties of the enveloped NPI. The optimization of this automatic procedure may provide a novel approach to obtain a large number of batches possibly suitable for large scale production of immunoisolated NPI for in vivo cell transplantation procedures in humans.
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The development of methods and processes to mass produce nanocomponents, materials with characteristic lengths less than 100 nm, has led to the emergence of a large number of consumer goods (nanoproducts) containing these materials. The unknown health effects and risks associate...
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Website Physical Activity Interventions: Preferences of Potential Users
ERIC Educational Resources Information Center
Ferney, Shannon L.; Marshall, Alison L.
2006-01-01
Information and communication technologies (particularly websites and e-mail) have the potential to deliver health behavior change programs to large numbers of adults at low cost. Controlled trials using these new media to promote physical activity have produced mixed results. User-centered development methods can assist in understanding the…
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Fungal phytotoxins as mediators of virulence.
Möbius, Nadine; Hertweck, Christian
2009-08-01
Many phytopathogenic fungi exert their destructive effects by producing and secreting toxic low molecular weight compounds. In the past years a large number of novel fungal virulence factors and their modes of action have been identified. This review highlights effective phytotoxin-mediated strategies to distress, weaken or kill the plant host.
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In order to screen large numbers of chemicals for their potential to produce developmental neurotoxicity new, in vitro methods are needed. One approach is to develop methods based on the biologic processes which underlie brain development including the growth and maturation of ce...
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Uranium isotopes quantitatively determined by modified method of atomic absorption spectrophotometry
NASA Technical Reports Server (NTRS)
Lee, G. H.
1967-01-01
Hollow-cathode discharge tubes determine the quantities of uranium isotopes in a sample by using atomic absorption spectrophotometry. Dissociation of the uranium atoms allows a large number of ground state atoms to be produced, absorbing the incident radiation that is different for the two major isotopes.
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REGRESSION MODELS THAT RELATE STREAMS TO WATERSHEDS: COPING WITH NUMEROUS, COLLINEAR PEDICTORS
GIS efforts can produce a very large number of watershed variables (climate, land use/land cover and topography, all defined for multiple areas of influence) that could serve as candidate predictors in a regression model of reach-scale stream features. Invariably, many of these ...
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NASA Astrophysics Data System (ADS)
Aghasibeig, M.; Mousavi, M.; Ben Ettouill, F.; Moreau, C.; Wuthrich, R.; Dolatabadi, A.
2014-01-01
Ni-based electrode coatings with enhanced surface areas, for hydrogen production, were developed using atmospheric plasma spray (APS) and suspension plasma spray (SPS) processes. The results revealed a larger electrochemical active surface area for the coatings produced by SPS compared to those produced by APS process. SEM micrographs showed that the surface microstructure of the sample with the largest surface area was composed of a large number of small cauliflower-like aggregates with an average diameter of 10 μm.
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1990-01-01
shelters). During this long period a large number of different projectile point types were produced (i.e., Rice Lobed, Big Sand,,, Graham Cave, Kirk Corner...Notched, White River Archaic, Hidden Valley Stemmed, Hardin Barbed, Searcy, Rice Lanceolate, Jakie Stemmed, and Johnson). Five Early Archaic points...Edrington, Mabel 1962 History of Mississippi County, Arkansas. Ocala Star Banner, Ocala, Florida. Elvas, Gentleman of 1851 An Account of the Expedition
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NASA Astrophysics Data System (ADS)
Boozer, Allen H.
1999-11-01
Modern stellarators are designed using J. Nuehrenberg’s method of varying Fourier coefficients in the shape of the plasma boundary to maximize a target function. The matrix of second derivatives of the target function at the optimum determines a quality matrix. This matrix gives the degradation in the quality of the configuration as the normal magnetic field is varied on a control surface, which lies on or outside the plasma surface. The task is finding saddle coils that produce the desired configuration in the presence of a given toroidal field. An eigenvector of the quality matrix can be important for two reasons: (1) the normal field that must be produced by the saddles is large or (2) the eigenvalue is large (an island-causing resonant perturbation). The rank of the important part of the quality matrix is the number of important eigenvectors. The current in each saddle coil produces a normal field on the control surface, which can be described by an inductance matrix. The relevant part of the inductance matrix has large eigenvalues. The coils can produce the configuration if the rank of the important part of the quality matrix and its product with the relevant part of the inductance matrix are the same. Existing coil design codes, pioneered by P. Merkel, approximate the quality matrix by the unit matrix. Stellarator flexibility could be enhanced by using a more realistic quality matrix and by using trim coils to balance large eigenvalues.
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Thermalization after/during reheating
NASA Astrophysics Data System (ADS)
Harigaya, Keisuke; Mukaida, Kyohei
2014-05-01
If reheating of the Universe takes place via Planck-suppressed decay, it seems that the thermalization of produced particles might be delayed, since they have large energy/small number densities and number violating large angle scatterings which decrease the momentum of particles by large amount are inefficient correspondingly. In this paper, we study the thermalization of such "under occupied" decay products in detail, following recent developments in understanding the thermalization of non-abelian plasma. Contrary to the above naive expectation, it is shown that in most cases thermalization after/during reheating occurs instantaneously by properly taking account of scatterings with small angles and of particles with small momenta. In particular, the condition for instantaneous thermalization before the completion of reheating is found to be , which is much milder than that obtained in previous works with small angle scatterings taken into account.
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NASA Astrophysics Data System (ADS)
Edholm, James
2018-03-01
General Relativity is known to produce singularities in the potential generated by a point source. Our universe can be modeled as a de Sitter (dS) metric and we show that ghost-free infinite derivative gravity (IDG) produces a nonsingular potential around a dS background, while returning to the GR prediction at large distances. We also show that although there are an apparently infinite number of coefficients in the theory, only a finite number actually affect the predictions. By writing the linearized equations of motion in a simplified form, we find that at distances below the Hubble length scale, the difference between the IDG potential around a flat background and around a de Sitter background is negligible.
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Large inserts for big data: artificial chromosomes in the genomic era.
Tocchetti, Arianna; Donadio, Stefano; Sosio, Margherita
2018-05-01
The exponential increase in available microbial genome sequences coupled with predictive bioinformatic tools is underscoring the genetic capacity of bacteria to produce an unexpected large number of specialized bioactive compounds. Since most of the biosynthetic gene clusters (BGCs) present in microbial genomes are cryptic, i.e. not expressed under laboratory conditions, a variety of cloning systems and vectors have been devised to harbor DNA fragments large enough to carry entire BGCs and to allow their transfer in suitable heterologous hosts. This minireview provides an overview of the vectors and approaches that have been developed for cloning large BGCs, and successful examples of heterologous expression.
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NASA Technical Reports Server (NTRS)
Fleming, J. R.; Holden, S. C.; Wolfson, R. G.
1979-01-01
The use of multiblade slurry sawing to produce silicon wafers from ingots was investigated. The commercially available state of the art process was improved by 20% in terms of area of silicon wafers produced from an ingot. The process was improved 34% on an experimental basis. Economic analyses presented show that further improvements are necessary to approach the desired wafer costs, mostly reduction in expendable materials costs. Tests which indicate that such reduction is possible are included, although demonstration of such reduction was not completed. A new, large capacity saw was designed and tested. Performance comparable with current equipment (in terms of number of wafers/cm) was demonstrated.
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Supermassive Black Holes and Galaxy Evolution
NASA Technical Reports Server (NTRS)
Merritt, D.
2004-01-01
Supermassive black holes appear to be generic components of galactic nuclei. The formation and growth of black holes is intimately connected with the evolution of galaxies on a wide range of scales. For instance, mergers between galaxies containing nuclear black holes would produce supermassive binaries which eventually coalesce via the emission of gravitational radiation. The formation and decay of these binaries is expected to produce a number of observable signatures in the stellar distribution. Black holes can also affect the large-scale structure of galaxies by perturbing the orbits of stars that pass through the nucleus. Large-scale N-body simulations are beginning to generate testable predictions about these processes which will allow us to draw inferences about the formation history of supermassive black holes.
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Hypervelocity nanoparticle impacts on free-standing graphene: A sui generis mode of sputtering
DOE Office of Scientific and Technical Information (OSTI.GOV)
Eller, Michael J.; Della-Negra, Serge; Liang, Chao-Kai
The study of the interaction of hypervelocity nano-particles with a 2D material and ultra-thin targets (single layer graphene, multi-layer graphene, and amorphous carbon foils) has been performed using mass selected gold nano-particles produced from a liquid metal ion source. During these impacts, a large number of atoms are ejected from the graphene, corresponding to a hole of ∼60 nm{sup 2}. Additionally, for the first time, secondary ions have been observed simultaneously in both the transmission and reflection direction (with respect to the path of the projectile) from a 2D target. The ejected area is much larger than that predicted bymore » molecular dynamic simulations and a large ionization rate is observed. The mass distribution and characteristics of the emitted secondary ions are presented and offer an insight into the process to produce the large hole observed in the graphene.« less
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NASA Astrophysics Data System (ADS)
Yiǧit, Erdal; Kilcik, Ali; Elias, Ana Georgina; Dönmez, Burçin; Ozguc, Atila; Yurchshyn, Vasyl; Rozelot, Jean-Pierre
2018-06-01
The long term solar activity dependencies of ionospheric F1 and F2 regions' critical frequencies (f0F1 and f0F2) are analyzed for the last four solar cycles (1976-2015). We show that the ionospheric F1 and F2 regions have different solar activity dependencies in terms of the sunspot group (SG) numbers: F1 region critical frequency (f0F1) peaks at the same time with the small SG numbers, while the f0F2 reaches its maximum at the same time with the large SG numbers, especially during the solar cycle 23. The observed differences in the sensitivity of ionospheric critical frequencies to sunspot group (SG) numbers provide a new insight into the solar activity effects on the ionosphere and space weather. While the F1 layer is influenced by the slow solar wind, which is largely associated with small SGs, the ionospheric F2 layer is more sensitive to Coronal Mass Ejections (CMEs) and fast solar winds, which are mainly produced by large SGs and coronal holes. The SG numbers maximize during of peak of the solar cycle and the number of coronal holes peaks during the sunspot declining phase. During solar minimum there are relatively less large SGs, hence reduced CME and flare activity. These results provide a new perspective for assessing how the different regions of the ionosphere respond to space weather effects.
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Survey of selective solar absorbers and their limitations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mattox, D.M.; Sowell, R.R.
1980-01-01
A number of selective absorber coating systems with high solar absorptance exist which may be used in the mid-temperature range. Some of the systems are more chemically and thermally stable than others. Unfortunately, there are large gaps in the stability data for a large number of the systems. In an inert environment, the principle degradation mechanisms are interdiffusion between the layers or phases and changes in surface morphology. These degradation mechanisms would be minimized by using refractory metals and compounds for the absorbing layer and using refractory materials or diffusion barriers for the underlayer. For use in a reactive environment,more » the choice of materials is much more restrictive since internal chemical reactions can change phase compositions and interfacial reactions can lead to loss of adhesion. For a coating process to be useful, it is necessary to determine what parameters influence the performance of the coating and the limits to these parameters. This process sensitivity has a direct influence on the production process controls necessary to produce a good product. Experience with electroplated black chrome has been rather disappointing. Electroplating should be a low cost deposition process but the extensive bath analysis and optical monitoring necessary to produce a thermally stable produce for use to 320/sup 0/C has increased cost signficantly. 49 references.« less
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Ghosh, Purabi R.; Fawcett, Derek; Sharma, Shashi B.; Poinern, Gerrard E. J.
2017-01-01
The quantities of organic waste produced globally by aquacultural and horticulture are extremely large and offer an attractive renewable source of biomolecules and bioactive compounds. The availability of such large and diverse sources of waste materials creates a unique opportunity to develop new recycling and food waste utilisation strategies. The aim of this review is to report the current status of research in the emerging field of producing high-value nanoparticles from food waste. Eco-friendly biogenic processes are quite rapid, and are usually carried out at normal room temperature and pressure. These alternative clean technologies do not rely on the use of the toxic chemicals and solvents commonly associated with traditional nanoparticle manufacturing processes. The relatively small number of research articles in the field have been surveyed and evaluated. Among the diversity of waste types, promising candidates and their ability to produce various high-value nanoparticles are discussed. Experimental parameters, nanoparticle characteristics and potential applications for nanoparticles in pharmaceuticals and biomedical applications are discussed. In spite of the advantages, there are a number of challenges, including nanoparticle reproducibility and understanding the formation mechanisms between different food waste products. Thus, there is considerable scope and opportunity for further research in this emerging field. PMID:28773212
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Perturbations of the Richardson number field by gravity waves
NASA Technical Reports Server (NTRS)
Wurtele, M. G.; Sharman, R. D.
1985-01-01
An analytic solution is presented for a stratified fluid of arbitrary constant Richardson number. By computer aided analysis the perturbation fields, including that of the Richardson number can be calculated. The results of the linear analytic model were compared with nonlinear simulations, leading to the following conclusions: (1) the perturbations in the Richardson number field, when small, are produced primarily by the perturbations of the shear; (2) perturbations of in the Richardson number field, even when small, are not symmetric, the increase being significantly larger than the decrease (the linear analytic solution and the nonlinear simulations both confirm this result); (3) as the perturbations grow, this asymmetry increases, but more so in the nonlinear simulations than in the linear analysis; (4) for large perturbations of the shear flow, the static stability, as represented by N2, is the dominating mechanism, becoming zero or negative, and producing convective overturning; and (5) the convectional measure of linearity in lee wave theory, NH/U, is no longer the critical parameter (it is suggested that (H/u sub 0) (du sub 0/dz) takes on this role in a shearing flow).
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Preparation of Activated Carbon from Palm Shells Using KOH and ZnCl2 as the Activating Agent
NASA Astrophysics Data System (ADS)
Yuliusman; Nasruddin; Afdhol, M. K.; Amiliana, R. A.; Hanafi, A.
2017-07-01
Palm shell is a potential source of raw materials for the produce of activated carbon as biosorbent for quite large numbers. The purpose of this study is to produce activated carbon qualified Indonesian Industrial Standard (SNI), which will be used as biosorbent to purify the impurities in the off gas petroleum refinery products. Stages of manufacture of activated carbon include carbonization, activation of chemistry and physics. Carbonization of activated carbon is done at a temperature of 400°C followed by chemical activation with active agent KOH and ZnCl2. Then the physical activation is done by flowing N2 gas for 1 hour at 850°C and followed by gas flow through the CO2 for 1 hour at 850°C. Research results indicate that activation of the active agent KOH produce activated carbon is better than using the active agent ZnCl2. The use of KOH as an active agent to produce activated carbon with a water content of 13.6%, ash content of 9.4%, iodine number of 884 mg/g and a surface area of 1115 m2/g. While the use of ZnCl2 as the active agent to produce activated carbon with a water content of 14.5%, total ash content of 9.0%, iodine number 648 mg/g and a surface area of 743 m2/g.
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Evidence of marine ice-cliff instability in Pine Island Bay from iceberg-keel plough marks
NASA Astrophysics Data System (ADS)
Wise, Matthew G.; Dowdeswell, Julian A.; Jakobsson, Martin; Larter, Robert D.
2017-10-01
Marine ice-cliff instability (MICI) processes could accelerate future retreat of the Antarctic Ice Sheet if ice shelves that buttress grounding lines more than 800 metres below sea level are lost. The present-day grounding zones of the Pine Island and Thwaites glaciers in West Antarctica need to retreat only short distances before they reach extensive retrograde slopes. When grounding zones of glaciers retreat onto such slopes, theoretical considerations and modelling results indicate that the retreat becomes unstable (marine ice-sheet instability) and thus accelerates. It is thought that MICI is triggered when this retreat produces ice cliffs above the water line with heights approaching about 90 metres. However, observational evidence confirming the action of MICI has not previously been reported. Here we present observational evidence that rapid deglacial ice-sheet retreat into Pine Island Bay proceeded in a similar manner to that simulated in a recent modelling study, driven by MICI. Iceberg-keel plough marks on the sea-floor provide geological evidence of past and present iceberg morphology, keel depth and drift direction. From the planform shape and cross-sectional morphologies of iceberg-keel plough marks, we find that iceberg calving during the most recent deglaciation was not characterized by small numbers of large, tabular icebergs as is observed today, which would produce wide, flat-based plough marks or toothcomb-like multi-keeled plough marks. Instead, it was characterized by large numbers of smaller icebergs with V-shaped keels. Geological evidence of the form and water-depth distribution of the plough marks indicates calving-margin thicknesses equivalent to the threshold that is predicted to trigger ice-cliff structural collapse as a result of MICI. We infer rapid and sustained ice-sheet retreat driven by MICI, commencing around 12,300 years ago and terminating before about 11,200 years ago, which produced large numbers of icebergs smaller than the typical tabular icebergs produced today. Our findings demonstrate the effective operation of MICI in the past, and highlight its potential contribution to accelerated future retreat of the Antarctic Ice Sheet.
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Multiplicative Forests for Continuous-Time Processes
Weiss, Jeremy C.; Natarajan, Sriraam; Page, David
2013-01-01
Learning temporal dependencies between variables over continuous time is an important and challenging task. Continuous-time Bayesian networks effectively model such processes but are limited by the number of conditional intensity matrices, which grows exponentially in the number of parents per variable. We develop a partition-based representation using regression trees and forests whose parameter spaces grow linearly in the number of node splits. Using a multiplicative assumption we show how to update the forest likelihood in closed form, producing efficient model updates. Our results show multiplicative forests can be learned from few temporal trajectories with large gains in performance and scalability. PMID:25284967
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Multiplicative Forests for Continuous-Time Processes.
Weiss, Jeremy C; Natarajan, Sriraam; Page, David
2012-01-01
Learning temporal dependencies between variables over continuous time is an important and challenging task. Continuous-time Bayesian networks effectively model such processes but are limited by the number of conditional intensity matrices, which grows exponentially in the number of parents per variable. We develop a partition-based representation using regression trees and forests whose parameter spaces grow linearly in the number of node splits. Using a multiplicative assumption we show how to update the forest likelihood in closed form, producing efficient model updates. Our results show multiplicative forests can be learned from few temporal trajectories with large gains in performance and scalability.
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Sosson, Charlotte; Georges, Carrie; Guillaume, Mathieu; Schuller, Anne-Marie; Schiltz, Christine
2018-01-01
Numbers are thought to be spatially organized along a left-to-right horizontal axis with small/large numbers on its left/right respectively. Behavioral evidence for this mental number line (MNL) comes from studies showing that the reallocation of spatial attention by active left/right head rotation facilitated the generation of small/large numbers respectively. While spatial biases in random number generation (RNG) during active movement are well established in adults, comparable evidence in children is lacking and it remains unclear whether and how children's access to the MNL is affected by active head rotation. To get a better understanding of the development of embodied number processing, we investigated the effect of active head rotation on the mean of generated numbers as well as the mean difference between each number and its immediately preceding response (the first order difference; FOD) not only in adults ( n = 24), but also in 7- to 11-year-old elementary school children ( n = 70). Since the sign and absolute value of FODs carry distinct information regarding spatial attention shifts along the MNL, namely their direction (left/right) and size (narrow/wide) respectively, we additionally assessed the influence of rotation on the total of negative and positive FODs regardless of their numerical values as well as on their absolute values. In line with previous studies, adults produced on average smaller numbers and generated smaller mean FODs during left than right rotation. More concretely, they produced more negative/positive FODs during left/right rotation respectively and the size of negative FODs was larger (in terms of absolute value) during left than right rotation. Importantly, as opposed to adults, no significant differences in RNG between left and right head rotations were observed in children. Potential explanations for such age-related changes in the effect of active head rotation on RNG are discussed. Altogether, the present study confirms that numerical processing is spatially grounded in adults and suggests that its embodied aspect undergoes significant developmental changes.
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Molecular techniques for detection of confused flour beetle infestations in stored products
USDA-ARS?s Scientific Manuscript database
Tribolium confusum (confused flour beetle) is a stored-product pest which contaminates a wide range of food products, from flour and cereals to spices. The insect reduces food quality and is responsible for large economic losses every year. Although a number of methods for detection of stored-produc...
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A Matter of Degrees: How Undergraduate College Completions Shape Labor Supply
ERIC Educational Resources Information Center
Fogg, Neeta P.; Harrington, Paul E.
2004-01-01
Perhaps more than any other measure of higher education, college completions provide an indication of the contributions of this important sector to the economy and to society at large. Measured by the number and kinds of degrees and certificates awarded during a given period, completions represent the output produced by colleges. Degree…
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USDA-ARS?s Scientific Manuscript database
There is a large variation in local commodity prices across the United States, with farmers receiving less for their soybeans produced on their farm, and paying more for meal to feed their livestock, thereby reducing their profitability. This price differential is due to a number of factors includin...
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Relationships between child-rearing styles and child behavior over time.
Chamberlin, R W
1978-02-01
We investigate the hypothesis that "authoritarian" styles of child rearing will lead to more home and school problems than will "accommodative" styles. One hundred thirty-five children have been followed up from age 2 into first grade. Follow-up observations show no significant differences between groups on any of the scores indicating malfunctioning for boys or girls at home or school. However, the home behavior of boys being raised with accommodative styles was described in more positive terms by their mothers than those raised with authoritarian styles. The accommodatively raisded girls were described in more positive terms by their first grade teachers. We found no evidence in this study that the permissive style is producing large numbers of "spoiled brats" nor that the authoritarian styles are producing large numbers of overly aggressive or inhibited children. The way parents handle authority relationships is not sufficientyl predictive of later problems to warrant any widespread attempts by physicians to change them. The physician should respect individual differences in child-rearing syle and only intervene where there is substantial evidence that a particular approach is having a harmful effect.
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Gridded Hourly Text Products: A TRMM Data Reduction Approach
NASA Technical Reports Server (NTRS)
Stocker, Erich; Kwiatkowski, John; Kelley, Owen; Wharton, Stephen W. (Technical Monitor)
2001-01-01
The quantity of precipitation data from satellite-based observations is a blessing and a curse. The sheer volume of the data makes it difficult for many researchers to use in targeted applications. This volume increases further as algorithm improvements lead to the reprocessing of mission data. In addition to the overall volume of data, the size and format complexity of orbital granules contribute to the difficulty in using all the available data. Finally, the number of different instruments available to measure rainfall and related parameters further contributes to the volume concerns. In summary, we have an embarrassment of riches. The science team of the Tropical Rainfall Measuring Mission (TRMM) recognized this dilemma and has developed a strategy to address it. The TRMM Science Data and Information System (TSDIS) produces, at the direction of the Joint TRMM Science Team, a number of instantaneous rainfall products. The TRMM Microwave Imager (TMI), the Precipitation Radar and a Combined TMI/PR are the key "instruments" used in this production. Each of these products contains an entire orbit of data. The algorithm code computes not just rain rates but a large number of other physical parameters as well as information needed for monitoring algorithm performance. That makes these products very large. For example, a single orbit of TMI rain rate product is 99 MB, a single orbit of the combined product yields a granule that is 158 MB, while the 80 vertical levels of rain information from the PR yields an orbital product of 253 MB. These are large products that are often difficult for science users to electronically transfer to their sites especially if they want a large period of time. Level 3 gridded products are much smaller, but their 5 or 30 day temporal resolution is insufficient for many researchers. In addition, TRMM standard products are produced in the HDF format. While a large number of user-friendly tools are available to hide the details of the format (including a toolkit developed at TSDIS for the TRMM science team), many potential users shy away
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System for plotting subsoil structure and method therefor
NASA Technical Reports Server (NTRS)
Narasimhan, K. Y.; Nathan, R.; Parthasarathy, S. P. (Inventor)
1980-01-01
Data for use in producing a tomograph of subsoil structure between boreholes is derived by pacing spaced geophones in one borehole, on the Earth surface if desired, and by producing a sequence of shots at spaced apart locations in the other borehole. The signals, detected by each of the geophones from the various shots, are processed either on a time of arrival basis, or on the basis of signal amplitude, to provide information of the characteristics of a large number of incremental areas between the boreholes. Such information is useable to produce a tomograph of the subsoil structure between the boreholes. By processing signals of relatively high frequencies, e.g., up to 100 Hz, and by closely spacing the geophones, a high resolution tomograph can be produced.
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Multicategory Composite Least Squares Classifiers
Park, Seo Young; Liu, Yufeng; Liu, Dacheng; Scholl, Paul
2010-01-01
Classification is a very useful statistical tool for information extraction. In particular, multicategory classification is commonly seen in various applications. Although binary classification problems are heavily studied, extensions to the multicategory case are much less so. In view of the increased complexity and volume of modern statistical problems, it is desirable to have multicategory classifiers that are able to handle problems with high dimensions and with a large number of classes. Moreover, it is necessary to have sound theoretical properties for the multicategory classifiers. In the literature, there exist several different versions of simultaneous multicategory Support Vector Machines (SVMs). However, the computation of the SVM can be difficult for large scale problems, especially for problems with large number of classes. Furthermore, the SVM cannot produce class probability estimation directly. In this article, we propose a novel efficient multicategory composite least squares classifier (CLS classifier), which utilizes a new composite squared loss function. The proposed CLS classifier has several important merits: efficient computation for problems with large number of classes, asymptotic consistency, ability to handle high dimensional data, and simple conditional class probability estimation. Our simulated and real examples demonstrate competitive performance of the proposed approach. PMID:21218128
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When fruits lose to animals: Disorganized search of semantic memory in Parkinson's disease.
Tagini, Sofia; Seyed-Allaei, Shima; Scarpina, Federica; Toraldo, Alessio; Mauro, Alessandro; Cherubini, Paolo; Reverberi, Carlo
2018-04-16
The semantic fluency task is widely used in both clinical and research settings to assess both the integrity of the semantic store and the effectiveness of the search through it. Our aim was to investigate whether nondemented Parkinson's disease (PD) patients show an impairment in the strategic exploration of the semantic store and whether the tested semantic category has an impact on multiple measures of performance. We compared 74 nondemented PD patients with 254 healthy subjects in a semantic fluency test using relatively small (fruits) and large (animals) semantic categories. Number of words produced, number of explored semantic subcategories, and degree of order in the produced sequences were computed as dependent variables. PD patients produced fewer words than healthy subjects did, regardless of the category. Number of subcategories was also lower in PD patients than in healthy subjects, without a significant difference between categories. Critically, PD patients' sequences were less semantically organized than were those of controls, but this effect appeared in only the smaller category (fruits), thus pointing to a lack of strategy in exploring the semantic store. Our results show that the semantic fluency deficit in PD patients has a strategic component, even though that may not be the only cause of the impaired performance. Furthermore, our evidence suggests that the semantic category used in the test influences performance, hence providing an explanation for the failure by previous studies, which often used large categories such as animals, to detect strategy deficits in PD. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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NASA Technical Reports Server (NTRS)
Thompson, D. R.; Wehmanen, O. A. (Principal Investigator)
1978-01-01
The author has identified the following significant results. The Green Number Index technique which uses LANDSAT digital data from 5X6 nautical mile sampling frames was expanded to evaluate its usefulness in detecting and monitoring vegetative water stress over the Great Plains. At known growth stages for wheat, segments were classified as drought or non drought. Good agreement was found between the 18 day remotely sensed data and a weekly ground-based crop moisture index. Operational monitoring of the 1977 U.S.S.R. and Australian wheat crops indicated drought conditions. Drought isoline maps produced by the Green Number Index technique were in good agreement with conventional sources.
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Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies.
Murphy, Jittawadee R; Weiss, Walter R; Fryauff, David; Dowler, Megan; Savransky, Tatyana; Stoyanov, Cristina; Muratova, Olga; Lambert, Lynn; Orr-Gonzalez, Sachy; Zeleski, Katie Lynn; Hinderer, Jessica; Fay, Michael P; Joshi, Gyan; Gwadz, Robert W; Richie, Thomas L; Villasante, Eileen Franke; Richardson, Jason H; Duffy, Patrick E; Chen, Jingyang
2014-06-03
When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. Several species and strains of mosquitoes were tested for their ability to produce Plasmodium knowlesi sporozoites. Donor monkey parasitaemia effects on oocyst and sporozoite numbers and mosquito mortality were documented. Methylparaben added to mosquito feed was tested to improve mosquito survival. To determine the number of bites needed to infect a monkey, animals were exposed to various numbers of P. knowlesi-infected mosquitoes. Finally, P. knowlesi-infected mosquitoes were used to challenge 17 monkeys in a malaria vaccine trial, and the effect of number of infectious bites on monkey parasitaemia was documented. Anopheles dirus, Anopheles crascens, and Anopheles dirus X (a cross between the two species) produced large numbers of P. knowlesi sporozoites. Mosquito survival to day 14, when sporozoites fill the salivary glands, averaged only 32% when donor monkeys had a parasitaemia above 2%. However, when donor monkey parasitaemia was below 2%, mosquitoes survived twice as well and contained ample sporozoites in their salivary glands. Adding methylparaben to sugar solutions did not improve survival of infected mosquitoes. Plasmodium knowlesi was very infectious, with all monkeys developing blood stage infections if one or more infected mosquitoes successfully fed. There was also a dose-response, with monkeys that received higher numbers of infected mosquito bites developing malaria sooner. Anopheles dirus, An. crascens and a cross between these two species all were excellent vectors for P. knowlesi. High donor monkey parasitaemia was associated with poor mosquito survival. A single infected mosquito bite is likely sufficient to infect a monkey with P. knowlesi. It is possible to efficiently challenge large groups of monkeys by mosquito bite, which will be useful for P. knowlesi vaccine studies.
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Benchmarking Memory Performance with the Data Cube Operator
NASA Technical Reports Server (NTRS)
Frumkin, Michael A.; Shabanov, Leonid V.
2004-01-01
Data movement across a computer memory hierarchy and across computational grids is known to be a limiting factor for applications processing large data sets. We use the Data Cube Operator on an Arithmetic Data Set, called ADC, to benchmark capabilities of computers and of computational grids to handle large distributed data sets. We present a prototype implementation of a parallel algorithm for computation of the operatol: The algorithm follows a known approach for computing views from the smallest parent. The ADC stresses all levels of grid memory and storage by producing some of 2d views of an Arithmetic Data Set of d-tuples described by a small number of integers. We control data intensity of the ADC by selecting the tuple parameters, the sizes of the views, and the number of realized views. Benchmarking results of memory performance of a number of computer architectures and of a small computational grid are presented.
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Interferon γ limits the effectiveness of melanoma peptide vaccines.
Cho, Hyun-Il; Lee, Young-Ran; Celis, Esteban
2011-01-06
The development of effective therapeutic vaccines to generate tumor-reactive cytotoxic T lymphocytes (CTLs) continues to be a top research priority. However, in spite of some promising results, there are no clear examples of vaccines that eradicate established tumors. Most vaccines are ineffective because they generate low numbers of CTLs and because numerous immunosuppressive factors abound in tumor-bearing hosts. We designed a peptide vaccine that produces large numbers of tumor-reactive CTLs in a mouse model of melanoma. Surprisingly, CTL tumor recognition and antitumor effects decreased in the presence of interferon γ (IFNγ), a cytokine that can provide therapeutic benefit. Tumors exposed to IFNγ evade CTLs by inducing large amounts of noncognate major histocompatibility complex class I molecules, which limit T-cell activation and effector function. Our results demonstrate that peptide vaccines can eradicate large, established tumors in circumstances under which the inhibitory activities of IFNγ are curtailed.
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NASA Astrophysics Data System (ADS)
Pryds, N.; Toftmann, B.; Bilde-Sørensen, J. B.; Schou, J.; Linderoth, S.
2006-04-01
Films of yttria-stabilized zirconia (YSZ) on a polished silicon substrate of diameter up to 125 mm have been produced in a large-area pulsed laser deposition (PLD) setup under typical PLD conditions. The film thickness over the full film area has been determined by energy-dispersive X-ray spectrometry in a scanning electron microscope (SEM) with use of a method similar to one described by Bishop and Poole. The attenuation of the electron-induced X-rays from the Si wafer by the film was monitored at a number of points along a diameter and the thickness was determined by Monte Carlo simulations of the attenuation for various values of film thickness with the program CASINO. These results have been compared with direct measurements in the SEM of the film thickness on a cross-section on one of the wafers. The results of these measurements demonstrate the ability of this technique to accurately determine the thickness of a large film, i.e. up to diameters of 125 mm, in a relatively short time, without destroying the substrate, without the need of a standard sample and without the need of a flat substrate. We have also demonstrated that by controlling the deposition parameters large-area YSZ films with uniform thickness can be produced.
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A Data Driven Network Approach to Rank Countries Production Diversity and Food Specialization
Tu, Chengyi; Carr, Joel
2016-01-01
The easy access to large data sets has allowed for leveraging methodology in network physics and complexity science to disentangle patterns and processes directly from the data, leading to key insights in the behavior of systems. Here we use country specific food production data to study binary and weighted topological properties of the bipartite country-food production matrix. This country-food production matrix can be: 1) transformed into overlap matrices which embed information regarding shared production of products among countries, and or shared countries for individual products, 2) identify subsets of countries which produce similar commodities or subsets of commodities shared by a given country allowing for visualization of correlations in large networks, and 3) used to rank country fitness (the ability to produce a diverse array of products weighted on the type of food commodities) and food specialization (quantified on the number of countries producing a specific food product weighted on their fitness). Our results show that, on average, countries with high fitness produce both low and high specializion food commodities, whereas nations with low fitness tend to produce a small basket of diverse food products, typically comprised of low specializion food commodities. PMID:27832118
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Molecular characterization of baculovirus Bombyx mori nucleopolyhedrovirus polyhedron mutants.
Katsuma, S; Noguchi, Y; Shimada, T; Nagata, M; Kobayashi, M; Maeda, S
1999-01-01
Four newly isolated and two previously isolated polyhedron mutants of Bombyx mori nucleopolyhedrovirus (BmNPV) were studied. Two polyhedron deficient mutants, #126 and #136, produced small uncrystallized particles of polyhedrin in the nuclei and cytoplasm of infected cells. Mutant #211 produced a large number of variably sized polyhedra in the nucleus and #220 produced a few large cuboidal polyhedra in the nucleus. Mutant #24 and #128 were previously isolated BmNPV mutants. Mutant #24 could not produce polyhedrin mRNA and polyhedra produced by mutant #128 lacked oral infectivity. Nucleotide sequence analysis indicated that five mutants (#126, #136, #211, #220 and #128) had amino acid substitutions in polyhedrin and mutant #24 had a point mutation only in the promoter region of the polyhedrin gene. Cotransfection experiments showed that the altered phenotypes were due to the mutations found in the polyhedrin gene regions. In mutants #126 and #136, amino acid sequences of the nuclear localization signal of polyhedrin were identical to those of wild-type BmNPV, suggesting that this sequence was necessary but not sufficient for nuclear localization of polyhedrin. Electron microscopic observation revealed that fewer occluded virions were contained in polyhedra of #128 and #220.
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A Data Driven Network Approach to Rank Countries Production Diversity and Food Specialization.
Tu, Chengyi; Carr, Joel; Suweis, Samir
2016-01-01
The easy access to large data sets has allowed for leveraging methodology in network physics and complexity science to disentangle patterns and processes directly from the data, leading to key insights in the behavior of systems. Here we use country specific food production data to study binary and weighted topological properties of the bipartite country-food production matrix. This country-food production matrix can be: 1) transformed into overlap matrices which embed information regarding shared production of products among countries, and or shared countries for individual products, 2) identify subsets of countries which produce similar commodities or subsets of commodities shared by a given country allowing for visualization of correlations in large networks, and 3) used to rank country fitness (the ability to produce a diverse array of products weighted on the type of food commodities) and food specialization (quantified on the number of countries producing a specific food product weighted on their fitness). Our results show that, on average, countries with high fitness produce both low and high specializion food commodities, whereas nations with low fitness tend to produce a small basket of diverse food products, typically comprised of low specializion food commodities.
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Using First Differences to Reduce Inhomogeneity in Radiosonde Temperature Datasets.
NASA Astrophysics Data System (ADS)
Free, Melissa; Angell, James K.; Durre, Imke; Lanzante, John; Peterson, Thomas C.; Seidel, Dian J.
2004-11-01
The utility of a “first difference” method for producing temporally homogeneous large-scale mean time series is assessed. Starting with monthly averages, the method involves dropping data around the time of suspected discontinuities and then calculating differences in temperature from one year to the next, resulting in a time series of year-to-year differences for each month at each station. These first difference time series are then combined to form large-scale means, and mean temperature time series are constructed from the first difference series. When applied to radiosonde temperature data, the method introduces random errors that decrease with the number of station time series used to create the large-scale time series and increase with the number of temporal gaps in the station time series. Root-mean-square errors for annual means of datasets produced with this method using over 500 stations are estimated at no more than 0.03 K, with errors in trends less than 0.02 K decade-1 for 1960 97 at 500 mb. For a 50-station dataset, errors in trends in annual global means introduced by the first differencing procedure may be as large as 0.06 K decade-1 (for six breaks per series), which is greater than the standard error of the trend. Although the first difference method offers significant resource and labor advantages over methods that attempt to adjust the data, it introduces an error in large-scale mean time series that may be unacceptable in some cases.
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Factors associated with the number of calves born to Norwegian beef suckler cows.
Holmøy, Ingrid H; Nelson, Sindre T; Martin, Adam D; Nødtvedt, Ane
2017-05-01
A retrospective cohort study was performed to evaluate factors associated with the number of calves born to Norwegian beef suckler cows. Production data from 20,541 cows in 2210 herds slaughtered over a three-year period (1st of January 2010 to 23rd of January 2013) were extracted from the national beef cattle registry. This study's inclusion criteria were met for 16,917 cows (from 1858 herds) which gave birth to 50,578 calves. The median number of calves born per cow was 2 (min 1, max 18). Two multilevel Poisson regression models with herd random effects showed that early maturing breeds (Hereford and Aberdeen Angus) gave birth to more calves than late maturing breeds (Charolais and Limousin) in four out of five areas of Norway. The significant breed-region interaction indicated that the coastal South East region of Norway, which has a relatively long growing season and gentle topography, yielded the highest number of calves born for all but one breed (Simmental). Cows that needed assistance or experienced dystocia at their first calving produced fewer calves than those that did not: incidence rate ratio 0.87 (95% confidence interval (CI) 0.84-0.91) for assistance and 0.70 (95% CI: 0.66-0.75) for dystocia, respectively. Cows in larger herds (>30 cows) produced 11% more calves in their lifetime compared to cows in smaller herds (≤30 cows) (P<0.001). The herd random effects were highly significant, suggesting that unmeasured factors at the herd level were responsible for a large amount of the unexplained variation in the number of calves born. The large inter-herd variation indicate systematic differences in herd level factors influencing the number of calves born to each cow. Copyright © 2017 Elsevier B.V. All rights reserved.
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Direct femtosecond laser surface structuring of crystalline silicon at 400 nm
NASA Astrophysics Data System (ADS)
Nivas, Jijil JJ; Anoop, K. K.; Bruzzese, Riccardo; Philip, Reji; Amoruso, Salvatore
2018-03-01
We have analyzed the effects of the laser pulse wavelength (400 nm) on femtosecond laser surface structuring of silicon. The features of the produced surface structures are investigated as a function of the number of pulses, N, and compared with the surface textures produced by more standard near-infrared (800 nm) laser pulses at a similar level of excitation. Our experimental findings highlight the importance of the light wavelength for the formation of the supra-wavelength grooves, and, for a large number of pulses (N ≈ 1000), the generation of other periodic structures (stripes) at 400 nm, which are not observed at 800 nm. These results provide interesting information on the generation of various surface textures, addressing the effect of the laser pulse wavelength on the generation of grooves and stripes.
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Forecasting distribution of numbers of large fires
Eidenshink, Jeffery C.; Preisler, Haiganoush K.; Howard, Stephen; Burgan, Robert E.
2014-01-01
Systems to estimate forest fire potential commonly utilize one or more indexes that relate to expected fire behavior; however they indicate neither the chance that a large fire will occur, nor the expected number of large fires. That is, they do not quantify the probabilistic nature of fire danger. In this work we use large fire occurrence information from the Monitoring Trends in Burn Severity project, and satellite and surface observations of fuel conditions in the form of the Fire Potential Index, to estimate two aspects of fire danger: 1) the probability that a 1 acre ignition will result in a 100+ acre fire, and 2) the probabilities of having at least 1, 2, 3, or 4 large fires within a Predictive Services Area in the forthcoming week. These statistical processes are the main thrust of the paper and are used to produce two daily national forecasts that are available from the U.S. Geological Survey, Earth Resources Observation and Science Center and via the Wildland Fire Assessment System. A validation study of our forecasts for the 2013 fire season demonstrated good agreement between observed and forecasted values.
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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis.
Zhang, Chenyu; Lowery, Frank J; Yu, Dihua
2017-02-08
Metastasis, the spread and growth of malignant cells at secondary sites within a patient's body, accounts for > 90% of cancer-related mortality. Recently, impressive advances in novel therapies have dramatically prolonged survival and improved quality of life for many cancer patients. Sadly, incidence of brain metastatic recurrences is fast rising, and all current therapies are merely palliative. Hence, good experimental animal models are urgently needed to facilitate in-depth studies of the disease biology and to assess novel therapeutic regimens for preclinical evaluation. However, the standard in vivo metastasis assay via tail vein injection of cancer cells produces predominantly lung metastatic lesions; animals usually succumb to the lung tumor burden before any meaningful outgrowth of brain metastasis. Intracardiac injection of tumor cells produces metastatic lesions to multiple organ sites including the brain; however, the variability of tumor growth produced with this model is large, dampening its utility in evaluating therapeutic efficacy. To generate reliable and consistent animal models for brain metastasis study, here we describe a procedure for producing experimental brain metastasis in the house mouse (Mus musculus) via intracarotid injection of tumor cells. This approach allows one to produce large number of brain metastasis-bearing mice with similar growth and mortality characteristics, thus facilitating research efforts to study basic biological mechanisms and to assess novel therapeutic agents.
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NASA Astrophysics Data System (ADS)
Warrier, M.; Bhardwaj, U.; Hemani, H.; Schneider, R.; Mutzke, A.; Valsakumar, M. C.
2015-12-01
We report on molecular Dynamics (MD) simulations carried out in fcc Cu and bcc W using the Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) code to study (i) the statistical variations in the number of interstitials and vacancies produced by energetic primary knock-on atoms (PKA) (0.1-5 keV) directed in random directions and (ii) the in-cascade cluster size distributions. It is seen that around 60-80 random directions have to be explored for the average number of displaced atoms to become steady in the case of fcc Cu, whereas for bcc W around 50-60 random directions need to be explored. The number of Frenkel pairs produced in the MD simulations are compared with that from the Binary Collision Approximation Monte Carlo (BCA-MC) code SDTRIM-SP and the results from the NRT model. It is seen that a proper choice of the damage energy, i.e. the energy required to create a stable interstitial, is essential for the BCA-MC results to match the MD results. On the computational front it is seen that in-situ processing saves the need to input/output (I/O) atomic position data of several tera-bytes when exploring a large number of random directions and there is no difference in run-time because the extra run-time in processing data is offset by the time saved in I/O.
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Cultural Enrichment: Connecting African American Elementary Children to Academic Achievement
ERIC Educational Resources Information Center
Winston, Deborah L.
2011-01-01
A large, growing number of mis-educated American citizens are being produced by America's public schools. Many of these students are being funneled into the penal system shortly after dropping out of high school. This phenomenon is especially prevalent among African American male students, many of whom have withdrawn academically years prior…
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ERIC Educational Resources Information Center
Lawrence, Anna; Turnhout, Esther
2010-01-01
The demand for biodiversity data is increasing. Governments require standardised, objective data to underpin planning and conservation decisions. These data are produced by large numbers of (volunteer) natural historians and non-governmental organisations. This article analyses the interface between the state and the volunteer naturalists to…
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ERIC Educational Resources Information Center
Matthews, Paul H.; Karls, Anna C.; Doberneck, Diane M.; Springer, Nicole C.
2015-01-01
Although growing numbers of graduate students nationwide express interest in developing and documenting boundary-spanning skills in community-engaged research, teaching, and outreach, formal opportunities to do so are often limited, especially at the large research institutions producing most future faculty members. This article focuses on initial…
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Navigation Support and Social Visualization for Personalized E-Learning
ERIC Educational Resources Information Center
Hsiao, I-Han
2012-01-01
A large number of educational resources is now made available on the Web to support both regular classroom learning and online learning. However, the abundance of available content produced at least two problems: how to help students to find the most appropriate resources and how to engage them into using these resources and benefit from them.…
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Playing the Numbers: The Return of the Overeducated American?
ERIC Educational Resources Information Center
Doyle, William R.
2011-01-01
Is college worth it? In the midst of an ongoing recovery that has not sparked large-scale job growth, some observers and analysts of higher education have suggested that it may not pay an individual to pursue a college education. There is also ongoing debate about whether the economy needs as many college graduates as currently produced. The…
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Multichannel Compression: Effects of Reduced Spectral Contrast on Vowel Identification
ERIC Educational Resources Information Center
Bor, Stephanie; Souza, Pamela; Wright, Richard
2008-01-01
Purpose: To clarify if large numbers of wide dynamic range compression channels provide advantages for vowel identification and to measure its acoustic effects. Methods: Eight vowels produced by 12 talkers in the /hVd/ context were compressed using 1, 2, 4, 8, and 16 channels. Formant contrast indices (mean formant peak minus mean formant trough;…
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Interest in producing ethanol from bio-mass in an attempt to make transportation ecologically sustainable continues to grow. In recent years, a large number of assessments have been conducted to assess the environmental merit of biofuels. Two detailed reviews that looked at the s...
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Effects of byproducts amended lead contaminated urban soils on carrot yield and lead uptake
USDA-ARS?s Scientific Manuscript database
Lead (Pb) has been used to produce a large number of materials and manufactured products. In areas with a history of lead paint use, high vehicular traffic and/or areas close to urban and industrial centers, atmospheric lead deposition may be very high. Consequently, a high deposition of lead in u...
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Erickson, Ariane E.; Edmondson, Dennis; Chang, Fei-Chien; Wood, Dave; Gong, Alex; Levengood, Sheeny Lan; Zhang, Miqin
2016-01-01
The inability to produce large quantities of nanofibers has been a primary obstacle in advancement and commercialization of electrospinning technologies, especially when aligned nanofibers are desired. Here, we present a high-throughput centrifugal electrospinning (HTP-CES) system capable of producing a large number of highly-aligned nanofiber samples with high-yield and tunable diameters. The versatility of the design was revealed when bead-less nanofibers were produced from copolymer chitosan/polycaprolactone (C-PCL) solutions despite variations in polymer blend composition or spinneret needle gauge. Compared to conventional electrospinning techniques, fibers spun with the HTP-CES not only exhibited superior alignment, but also better diameter uniformity. Nanofiber alignment was quantified using Fast Fourier Transform (FFT) analysis. In addition, a concave correlation between the needle diameter and resultant fiber diameter was identified. This system can be easily scaled up for industrial production of highly-aligned nanofibers with tunable diameters that can potentially meet the requirements for various engineering and biomedical applications. PMID:26428148
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Jensen, Kimberly L; English, Burton C; Menard, R Jamey; Holland, Robert E
2009-01-01
Nationally, shortages of food-animal veterinary practitioners have been projected over the next several years. The purpose of this study was to ascertain livestock producers' perceptions on access to veterinary services and to measure opinions on potential solutions to access problems. Data for the study were from a 2006 survey of livestock producers in Tennessee. The study found that the majority of livestock producers had not perceived problems in obtaining veterinary services during the past year. Among those who had, the problems most commonly cited were a delay in obtaining services; that the veterinarian would treat the animal only if the producer transported it to the veterinary facility; and that the cost of the veterinary service was too high relative to the value of the animal. While it was hypothesized that producers who experienced a problem would have smaller farms on average and would reside in counties with lower numbers of large- or food-animal veterinarians, the results did not support this hypothesis. Among those who perceived a problem, scholarship programs to encourage veterinary students to specialize in large- or food-animal care and greater availability of veterinary technicians to perform health care services were viewed as effective ways to alleviate access problems. Financial incentives for veterinarians to locate in rural areas were also viewed as effective. While shortages have been predicted nationally, data from this survey do not suggest a perceived shortage in Tennessee. Problems in obtaining services appear to be more closely related to practice management and availability of large-animal practitioners in dairy and equine medicine.
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Armson, J; Stuart, A
1998-06-01
An ABA time series design was used to examine the effect of extended, continuous exposure to frequency-altered auditory feedback (FAF) during an oral reading and monologue task on stuttering frequency and speech rate. Twelve adults who stutter participated. A statistically significant decrease in number of stuttering events, an increase in number of syllables produced, and a decrease in percent stuttering was observed during the experimental segment relative to baseline segments for the oral reading task. In the monologue task, there were no statistically significant differences for the number of stuttering events, number of syllables produced, or percent stuttering between the experimental and baseline segments. Varying individual patterns of response to FAF were evident during the experimental segment of the reading task: a large consistent reduction in stuttering, an initial reduction followed by fluctuations in amount of stuttering, and essentially no change in stuttering frequency. Ten of 12 participants showed no reduction in stuttering frequency during the experimental segment of the monologue task. These findings have ramifications both for the clinical utilization of FAF and for theoretical explanations of fluency-enhancement.
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Hot cell purification of strontium-82, 85 and other isotopes from proton irradiated molybdenum
Bentley, G.E.; Barnes, J.W.
1979-10-17
A process suitable for producing curie quantities of quite pure Sr-82,85 is given. After a Mo target is irradiated with energetic protons having energies greater than about 200 MeV, thus producing a large number of radioactive species, the particular species of Sr-82,85 are substantially separated from the other products by a 6-step process. The process comprises dissolution of the target in H/sub 2/O/sub 2/, followed by use of several ion exchange resins, extraction with an organophosphorus compound, and several adjustments of pH values. Other embodiments include processes for producing relatively pure long-lived Rb isotopes, Y-88, and Zr-88.
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Hot cell purification of strontium-82, 85 and other isotopes from proton irradiated molybdenum
Bentley, Glenn E.; Barnes, John W.
1981-01-01
A process suitable for producing curie quantities of quite pure Sr-82,85 is given. After a Mo target is irradiated with energetic protons having energies greater than about 200 MeV, thus producing a large number of radioactive species, the particular species of Sr-82,85 are substantially separated from the other products by a 6-step process. The process comprises dissolution of the target in H.sub.2 O.sub.2, followed by use of several ion exchange resins, extraction with an organophosphorus compound, and several adjustments of pH values. Other embodiments include processes for producing relatively pure long-lived Rb isotopes, Y-88, and Zr-88.
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Extensive Error in the Number of Genes Inferred from Draft Genome Assemblies
Denton, James F.; Lugo-Martinez, Jose; Tucker, Abraham E.; Schrider, Daniel R.; Warren, Wesley C.; Hahn, Matthew W.
2014-01-01
Current sequencing methods produce large amounts of data, but genome assemblies based on these data are often woefully incomplete. These incomplete and error-filled assemblies result in many annotation errors, especially in the number of genes present in a genome. In this paper we investigate the magnitude of the problem, both in terms of total gene number and the number of copies of genes in specific families. To do this, we compare multiple draft assemblies against higher-quality versions of the same genomes, using several new assemblies of the chicken genome based on both traditional and next-generation sequencing technologies, as well as published draft assemblies of chimpanzee. We find that upwards of 40% of all gene families are inferred to have the wrong number of genes in draft assemblies, and that these incorrect assemblies both add and subtract genes. Using simulated genome assemblies of Drosophila melanogaster, we find that the major cause of increased gene numbers in draft genomes is the fragmentation of genes onto multiple individual contigs. Finally, we demonstrate the usefulness of RNA-Seq in improving the gene annotation of draft assemblies, largely by connecting genes that have been fragmented in the assembly process. PMID:25474019
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Extensive error in the number of genes inferred from draft genome assemblies.
Denton, James F; Lugo-Martinez, Jose; Tucker, Abraham E; Schrider, Daniel R; Warren, Wesley C; Hahn, Matthew W
2014-12-01
Current sequencing methods produce large amounts of data, but genome assemblies based on these data are often woefully incomplete. These incomplete and error-filled assemblies result in many annotation errors, especially in the number of genes present in a genome. In this paper we investigate the magnitude of the problem, both in terms of total gene number and the number of copies of genes in specific families. To do this, we compare multiple draft assemblies against higher-quality versions of the same genomes, using several new assemblies of the chicken genome based on both traditional and next-generation sequencing technologies, as well as published draft assemblies of chimpanzee. We find that upwards of 40% of all gene families are inferred to have the wrong number of genes in draft assemblies, and that these incorrect assemblies both add and subtract genes. Using simulated genome assemblies of Drosophila melanogaster, we find that the major cause of increased gene numbers in draft genomes is the fragmentation of genes onto multiple individual contigs. Finally, we demonstrate the usefulness of RNA-Seq in improving the gene annotation of draft assemblies, largely by connecting genes that have been fragmented in the assembly process.
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Growth of zeolite crystals in the microgravity environment of space
NASA Technical Reports Server (NTRS)
Sacco, A., Jr.; Sand, L. B.; Collette, D.; Dieselman, K.; Crowley, J.; Feitelberg, A.
1986-01-01
Zeolites are hydrated, crystalline aluminosilicates with alkali and alkaling earth metals substituted into cation vacancies. Typically zeolite crystals are 3 to 8 microns. Larger cyrstals are desirable. Large zeolite crystals were produced (100 to 200 microns); however, they have taken restrictively long times to grow. It was proposed if the rate of nucleation or in some other way the number of nuclei can be lowered, fewer, larger crystals will be formed. The microgravity environment of space may provide an ideal condition to achieve rapid growth of large zeolite crystals. The objective of the project is to establish if large zeolite crystals can be formed rapidly in space.
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SHEAR-DRIVEN DYNAMO WAVES IN THE FULLY NONLINEAR REGIME
DOE Office of Scientific and Technical Information (OSTI.GOV)
Pongkitiwanichakul, P.; Nigro, G.; Cattaneo, F.
2016-07-01
Large-scale dynamo action is well understood when the magnetic Reynolds number ( Rm ) is small, but becomes problematic in the astrophysically relevant large Rm limit since the fluctuations may control the operation of the dynamo, obscuring the large-scale behavior. Recent works by Tobias and Cattaneo demonstrated numerically the existence of large-scale dynamo action in the form of dynamo waves driven by strongly helical turbulence and shear. Their calculations were carried out in the kinematic regime in which the back-reaction of the Lorentz force on the flow is neglected. Here, we have undertaken a systematic extension of their work tomore » the fully nonlinear regime. Helical turbulence and large-scale shear are produced self-consistently by prescribing body forces that, in the kinematic regime, drive flows that resemble the original velocity used by Tobias and Cattaneo. We have found four different solution types in the nonlinear regime for various ratios of the fluctuating velocity to the shear and Reynolds numbers. Some of the solutions are in the form of propagating waves. Some solutions show large-scale helical magnetic structure. Both waves and structures are permanent only when the kinetic helicity is non-zero on average.« less
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Kusuma, Gina D.; Brennecke, Shaun P.; O’Connor, Andrea J.; Kalionis, Bill
2017-01-01
Mesenchymal stem/stromal cells (MSCs) exhibit undesired phenotypic changes during ex vivo expansion, limiting production of the large quantities of high quality primary MSCs needed for both basic research and cell therapies. Primary MSCs retain many desired MSC properties including proliferative capacity and differentiation potential when expanded on decellularized extracellular matrix (dECM) prepared from primary MSCs. However, the need to use low passage number primary MSCs (passage 3 or lower) to produce the dECM drastically limits the utility and impact of this technology. Here, we report that primary MSCs expanded on dECM prepared from high passage number (passage 25) human telomerase reverse transcriptase (hTERT) transduced immortal MSC cell lines also exhibit increased proliferation and osteogenic differentiation. Two hTERT-transduced placenta-derived MSC cell lines, CMSC29 and DMSC23 [derived from placental chorionic villi (CMSCs) and decidua basalis (DMSCs), respectively], were used to prepare dECM-coated substrates. These dECM substrates showed structural and biochemical differences. Primary DMSCs cultured on dECM-DMSC23 showed a three-fold increase in cell number after 14 days expansion in culture and increased osteogenic differentiation compared with controls. Primary CMSCs cultured on the dECM-DMSC23 exhibited a two-fold increase in cell number and increased osteogenic differentiation. We conclude that immortal MSC cell lines derived from different parts of the placenta produce dECM with varying abilities for supporting increased primary MSC expansion while maintaining important primary MSC properties. Additionally, this is the first demonstration of using high passage number cells to produce dECM that can promote primary MSC expansion, and this advancement greatly increases the feasibility and applicability of dECM-based technologies. PMID:28152107
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Kusuma, Gina D; Brennecke, Shaun P; O'Connor, Andrea J; Kalionis, Bill; Heath, Daniel E
2017-01-01
Mesenchymal stem/stromal cells (MSCs) exhibit undesired phenotypic changes during ex vivo expansion, limiting production of the large quantities of high quality primary MSCs needed for both basic research and cell therapies. Primary MSCs retain many desired MSC properties including proliferative capacity and differentiation potential when expanded on decellularized extracellular matrix (dECM) prepared from primary MSCs. However, the need to use low passage number primary MSCs (passage 3 or lower) to produce the dECM drastically limits the utility and impact of this technology. Here, we report that primary MSCs expanded on dECM prepared from high passage number (passage 25) human telomerase reverse transcriptase (hTERT) transduced immortal MSC cell lines also exhibit increased proliferation and osteogenic differentiation. Two hTERT-transduced placenta-derived MSC cell lines, CMSC29 and DMSC23 [derived from placental chorionic villi (CMSCs) and decidua basalis (DMSCs), respectively], were used to prepare dECM-coated substrates. These dECM substrates showed structural and biochemical differences. Primary DMSCs cultured on dECM-DMSC23 showed a three-fold increase in cell number after 14 days expansion in culture and increased osteogenic differentiation compared with controls. Primary CMSCs cultured on the dECM-DMSC23 exhibited a two-fold increase in cell number and increased osteogenic differentiation. We conclude that immortal MSC cell lines derived from different parts of the placenta produce dECM with varying abilities for supporting increased primary MSC expansion while maintaining important primary MSC properties. Additionally, this is the first demonstration of using high passage number cells to produce dECM that can promote primary MSC expansion, and this advancement greatly increases the feasibility and applicability of dECM-based technologies.
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Screen Space Ambient Occlusion Based Multiple Importance Sampling for Real-Time Rendering
NASA Astrophysics Data System (ADS)
Zerari, Abd El Mouméne; Babahenini, Mohamed Chaouki
2018-03-01
We propose a new approximation technique for accelerating the Global Illumination algorithm for real-time rendering. The proposed approach is based on the Screen-Space Ambient Occlusion (SSAO) method, which approximates the global illumination for large, fully dynamic scenes at interactive frame rates. Current algorithms that are based on the SSAO method suffer from difficulties due to the large number of samples that are required. In this paper, we propose an improvement to the SSAO technique by integrating it with a Multiple Importance Sampling technique that combines a stratified sampling method with an importance sampling method, with the objective of reducing the number of samples. Experimental evaluation demonstrates that our technique can produce high-quality images in real time and is significantly faster than traditional techniques.
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Damage threshold from large retinal spot size repetitive-pulse laser exposures.
Lund, Brian J; Lund, David J; Edsall, Peter R
2014-10-01
The retinal damage thresholds for large spot size, multiple-pulse exposures to a Q-switched, frequency doubled Nd:YAG laser (532 nm wavelength, 7 ns pulses) have been measured for 100 μm and 500 μm retinal irradiance diameters. The ED50, expressed as energy per pulse, varies only weakly with the number of pulses, n, for these extended spot sizes. The previously reported threshold for a multiple-pulse exposure for a 900 μm retinal spot size also shows the same weak dependence on the number of pulses. The multiple-pulse ED50 for an extended spot-size exposure does not follow the n dependence exhibited by small spot size exposures produced by a collimated beam. Curves derived by using probability-summation models provide a better fit to the data.
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On the use of the covariance matrix to fit correlated data
NASA Astrophysics Data System (ADS)
D'Agostini, G.
1994-07-01
Best fits to data which are affected by systematic uncertainties on the normalization factor have the tendency to produce curves lower than expected if the covariance matrix of the data points is used in the definition of the χ2. This paper shows that the effect is a direct consequence of the hypothesis used to estimate the empirical covariance matrix, namely the linearization on which the usual error propagation relies. The bias can become unacceptable if the normalization error is large, or a large number of data points are fitted.
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A Theoretical Investigation of Optical Emission in Solar Flares
NASA Astrophysics Data System (ADS)
Abbett, William Paul
A dynamic theoretical model of a flare loop from its footpoints in the photosphere to its apex in the corona is presented, and the effects of non-thermal heating of the lower atmosphere by accelerated electrons and soft X-ray irradiation from the flare heated transition region and corona are investigated. Important transitions of hydrogen, helium, and singly ionized calcium and magnesium are treated in non-LTE. Three main conclusions are drawn from the models. First, even the strongest of impulsive events can be described as having two phases: a gentle phase characterized by a state of near equilibrium, and an explosive phase characterized by large material flows, and strong hydrodynamic waves and shocks. During the gentle phase, one or possibly two temperature 'plateaus' form in the upper chromosphere. The line emission generated in these regions produces profiles that are generally symmetric and undistorted, in contrast to emission produced during the explosive phase, where large velocity gradients that occur in the upper atmosphere produce line profiles that are highly asymmetric and show large emission peaks and troughs. Second, a significant continuum (or 'white light') brightening results from increased hydrogen recombination radiation in the upper chromosphere at the point where the accelerated electrons deposit the bulk of their energy. Third, there exists a measurable time lag between the brightening of the near wings of Hα and the brightening of the Paschen continuum. This delay is controlled by the amount of time it takes for electron densities in the upper chromosphere to become high enough, and the densities of hydrogen atoms in high energy bound states to become low enough, to allow the number of recombinations to dominate the number of photoionizations in the region.
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Wave and particle evolution downstream of quasi-perpendicular shocks
NASA Technical Reports Server (NTRS)
Mckean, M. E.; Omidi, N.; Krauss-Varban, D.; Karimabadi, H.
1995-01-01
Distributions of ions heated in quasi-perpendicular bow shocks have large perpendicular temperature anisotropies that provide free energy for the growth of Alfven ion cyclotron (AIC) and mirror waves. These modes are often obsreved in the Earth's magnetosheath. Using two-dimensional hybrid simulations, we show that these waves are produced near the shock front and convected downstream rather than being produced locally downstream. The wave activity reduces the proton anisotropy to magnetosheath levels within a few tens of gyroradii of the shock but takes significantly longer to reduce the anisotropy of He(++) ions. The waves are primarily driven by proton anisotropy and the dynamics of the helium ions is controlled by the proton waves. Downstream of high Mach number shocks, mirror waves compete effectively with AIC waves. Downstream of low Mach number shocks, AIC waves dominate.
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Nonequilibrium electroweak baryogenesis at preheating after inflation
NASA Astrophysics Data System (ADS)
García-Bellido, Juan; Grigoriev, Dmitri; Kusenko, Alexander; Shaposhnikov, Mikhail
1999-12-01
We present a novel scenario for baryogenesis in a hybrid inflation model at the electroweak scale, in which the standard model Higgs field triggers the end of inflation. One of the conditions for successful baryogenesis, the departure from thermal equilibrium, is naturally achieved at the stage of preheating after inflation. The inflaton oscillations induce large occupation numbers for long-wavelength configurations of the Higgs and gauge fields, which leads to a large rate of sphaleron transitions. We estimate this rate during the first stages of reheating and evaluate the amount of baryons produced due to a particular type of higher-dimensional CP violating operator. The universe thermalizes through fermion interactions, at a temperature below critical, Trh<~100 GeV, preventing the wash-out of the produced baryon asymmetry. Numerical simulations in 1+1 dimensions support our theoretical analyses.
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Influence of dietary fiber on xylanolytic and cellulolytic bacteria of adult pigs.
Varel, V H; Robinson, I M; Jung, H J
1987-01-01
Xylanolytic and cellulolytic bacteria were enumerated over an 86-day period from fecal samples of 10 8-month-old gilts that were fed either a control or a 40% alfalfa meal (high-fiber) diet. Fecal samples were collected from all pigs on days 0, 3, 5, 12, 25, 37, 58, and 86. Overall, the numbers of xylanolytic bacteria producing greater than 5-mm-diameter zones of clearing on 0.24% xylan roll tube medium after 24 to 36 h of incubation were 1.6 X 10(8) and 4.2 X 10(8)/g (dry weight) of feces for the control pigs and those fed the high-fiber diet, respectively. After 1 week of incubation, a large number of smaller zones of clearing (1 to 2 mm) appeared. Besides Bacteroides succinogenes and Ruminococcus flavefaciens, which produced faint zones of clearing in xylan roll tubes, three strains which closely resembled B. ruminicola hydrolyzed and used xylan for growth. The overall numbers of cellulolytic bacteria producing zones of clearing in 0.5% agar roll tube medium were 0.36 X 10(8) and 4.1 X 10(8)/g for the control pigs and those fed the high-fiber diet, respectively. B. succinogenes was the predominant cellulolytic isolate from both groups of pigs, and R. flavefaciens was found in a ratio of approximately 1 to 15 with B. succinogenes. Degradation of xylan and cellulose, measured by in vitro dry matter disappearance after inoculation with fecal samples, was significantly greater for pigs fed the high-fiber diet than that for the controls. These data suggest that the number of fibrolytic microorganisms and their activity in the large intestine of the adult pig can be increased by feeding pigs high-alfalfa-fiber diets and that these organisms are similar to those found in the rumen. PMID:3030194
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The relativistic feedback discharge model of terrestrial gamma ray flashes
NASA Astrophysics Data System (ADS)
Dwyer, Joseph R.
2012-02-01
As thunderclouds charge, the large-scale fields may approach the relativistic feedback threshold, above which the production of relativistic runaway electron avalanches becomes self-sustaining through the generation of backward propagating runaway positrons and backscattered X-rays. Positive intracloud (IC) lightning may force the large-scale electric fields inside thunderclouds above the relativistic feedback threshold, causing the number of runaway electrons, and the resulting X-ray and gamma ray emission, to grow exponentially, producing very large fluxes of energetic radiation. As the flux of runaway electrons increases, ionization eventually causes the electric field to discharge, bringing the field below the relativistic feedback threshold again and reducing the flux of runaway electrons. These processes are investigated with a new model that includes the production, propagation, diffusion, and avalanche multiplication of runaway electrons; the production and propagation of X-rays and gamma rays; and the production, propagation, and annihilation of runaway positrons. In this model, referred to as the relativistic feedback discharge model, the large-scale electric fields are calculated self-consistently from the charge motion of the drifting low-energy electrons and ions, produced from the ionization of air by the runaway electrons, including two- and three-body attachment and recombination. Simulation results show that when relativistic feedback is considered, bright gamma ray flashes are a natural consequence of upward +IC lightning propagating in large-scale thundercloud fields. Furthermore, these flashes have the same time structures, including both single and multiple pulses, intensities, angular distributions, current moments, and energy spectra as terrestrial gamma ray flashes, and produce large current moments that should be observable in radio waves.
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NASA Astrophysics Data System (ADS)
Cécillon, Lauric; Quénéa, Katell; Anquetil, Christelle; Barré, Pierre
2015-04-01
Due to its large heterogeneity at all scales (from soil core to the globe), several measurements are often mandatory to get a meaningful value of a measured soil property. A large number of measurements can therefore be needed to study a soil property whatever the scale of the study. Moreover, several soil investigation techniques produce large and complex datasets, such as pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) which produces complex 3-way data. In this context, straightforward methods designed to speed up data treatments are needed to deal with large datasets. GC-MS pyrolysis (py-GCMS) is a powerful and frequently used tool to characterize soil organic matter (SOM). However, the treatment of the results of a py-GCMS analysis of soil sample is time consuming (number of peaks, co-elution, etc.) and the treatment of large data set of py-GCMS results is rather laborious. Moreover, peak position shifts and baseline drifts between analyses make the automation of GCMS programs data treatment difficult. These problems can be fixed using the Parallel Factor Analysis 2 (PARAFAC 2, Kiers et al., 1999; Bro et al., 1999). This algorithm has been applied frequently on chromatography data but has never been applied to analyses of SOM. We developed a Matlab routine based on existing Matlab packages dedicated to the simultaneous treatment of dozens of pyro-chromatograms mass spectra. We applied this routine on 40 soil samples. The benefits and expected improvements of our method will be discussed in our poster. References Kiers et al. (1999) PARAFAC2 - PartI. A direct fitting algorithm for the PARAFAC2 model. Journal of Chemometrics, 13: 275-294. Bro et al. (1999) PARAFAC2 - PartII. Modeling chromatographic data with retention time shifts. Journal of Chemometrics, 13: 295-309.
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A simple biosynthetic pathway for large product generation from small substrate amounts
NASA Astrophysics Data System (ADS)
Djordjevic, Marko; Djordjevic, Magdalena
2012-10-01
A recently emerging discipline of synthetic biology has the aim of constructing new biosynthetic pathways with useful biological functions. A major application of these pathways is generating a large amount of the desired product. However, toxicity due to the possible presence of toxic precursors is one of the main problems for such production. We consider here the problem of generating a large amount of product from a potentially toxic substrate. To address this, we propose a simple biosynthetic pathway, which can be induced in order to produce a large number of the product molecules, by keeping the substrate amount at low levels. Surprisingly, we show that the large product generation crucially depends on fast non-specific degradation of the substrate molecules. We derive an optimal induction strategy, which allows as much as three orders of magnitude increase in the product amount through biologically realistic parameter values. We point to a recently discovered bacterial immune system (CRISPR/Cas in E. coli) as a putative example of the pathway analysed here. We also argue that the scheme proposed here can be used not only as a stand-alone pathway, but also as a strategy to produce a large amount of the desired molecules with small perturbations of endogenous biosynthetic pathways.
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An improved soft-chemistry approach to the preparation of spinel powders
NASA Astrophysics Data System (ADS)
Cook, Ronald
2007-04-01
Spinel powders for the production of transparent polycrystalline ceramic windows have been produced using a number of traditional ceramic and sol-gel methods. We have demonstrated that magnesium aluminate spinel powders produced from the reaction of organo-magnesium compounds with surface modified boehmite precursors can be used to produce high quality transparent spinel parts. In previous work, the spinel powders were prepared by the reaction of surface-modified boehmite nanoparticles with magnesium acetylacetonate. While the magnesium acetylacetonate can produce small quantities of high quality spinel powders, it use for large scale production of spinel powders is problematic. Through a thermodynamic analysis we have identified a new high-purity, low-cost, low-toxicity organomagnesium compound that reacts the with surface modified boehmite nanoparticles to produce a spinel precursor. The magnesium doped precursor readily transforms into pure phase spinel at temperature between 900°C and 1200°C.
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Reproducing Vulnerability: A Bourdieuian Analysis of Readers Who Struggle in Neoliberal Times
ERIC Educational Resources Information Center
Jaeger, Elizabeth L.
2017-01-01
The neoliberal agenda promotes education as a route toward success in university and career. However, a neoliberal economy requires large numbers of workers willing to accept low-paying, dead-end jobs. The students most likely to take these jobs are those who have struggled with literacy and so schools must, in Bourdieu's terms, re/produce,…
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Tessore, Nicolas; Metcalf, R. Benton; Winther, Hans A.
A number of alternatives to general relativity exhibit gravitational screening in the non-linear regime of structure formation. We describe a set of algorithms that can produce weak lensing maps of large scale structure in such theories and can be used to generate mock surveys for cosmological analysis. By analysing a few basic statistics we indicate how these alternatives can be distinguished from general relativity with future weak lensing surveys.
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7 CFR 457.154 - Processing sweet corn crop insurance provisions.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 6 of the Basic Provisions, you must provide a copy of all processor contracts to us on or before the... or cold temperatures that cause an unexpected number of acres over a large producing area to be ready... circumstance or, if an indemnity has been paid, require you to repay it to us with interest at any time acreage...
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7 CFR 457.154 - Processing sweet corn crop insurance provisions.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 6 of the Basic Provisions, you must provide a copy of all processor contracts to us on or before the... or cold temperatures that cause an unexpected number of acres over a large producing area to be ready... circumstance or, if an indemnity has been paid, require you to repay it to us with interest at any time acreage...
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7 CFR 457.154 - Processing sweet corn crop insurance provisions.
Code of Federal Regulations, 2014 CFR
2014-01-01
... copy of all processor contracts to us on or before the acreage reporting date. 7. Insured Crop (a) In... or cold temperatures that cause an unexpected number of acres over a large producing area to be ready... circumstance or, if an indemnity has been paid, require you to repay it to us with interest at any time acreage...
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Broadening the focus of bat conservation and research in the USA for the 21st century
Theodore Weller; Paul Cryan; O’Shea Thomas
2009-01-01
Appropriately, bat conservation in the USA during the 20th century focused on species that tend to aggregate in large numbers and locations (e.g. maternity roosts, hibernacula) where populations are most vulnerable. Extensive research into habitat needs (primarily for roosting) of reproductive females during the previous 2 decades has produced a wealth of information...
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Will crown ideotype help determine optimum varietal silviculture?
Timothy J. Albaugh; Thomas R. Fox; Marco A. Yanez; Rafael A. Rubilar; Barry Goldfarb
2016-01-01
Recent advances in somatic embryogenesis permit large numbers of clonal loblolly pine (Pinus taeda L.) to be produced and deployed. Clones may have greater growth (mean annual increment exceeding 30 cubic meters per hectare per year), greater stand uniformity and may be more susceptible to genotype by environment interactions when they are deployed in intensively...
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The DTIC Review: Volume 2, Number 4, Surviving Chemical and Biological Warfare
1996-12-01
CHROMATOGRAPHIC ANALYSIS, NUCLEAR MAGNETIC RESONANCE, INFRARED SPECTROSCOPY , ARMY RESEARCH, DEGRADATION, VERIFICATION, MASS SPECTROSCOPY , LIQUID... mycotoxins . Such materials are not attractive as weapons of mass destruction however, as large amounts are required to produce lethal effects. In...VERIFICATION, ATOMIC ABSORPTION SPECTROSCOPY , ATOMIC ABSORPTION. AL The DTIC Review Defense Technical Information Center AD-A285 242 AD-A283 754 EDGEWOOO
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Analysis of Covariance: Is It the Appropriate Model to Study Change?
ERIC Educational Resources Information Center
Marston, Paul T., Borich, Gary D.
The four main approaches to measuring treatment effects in schools; raw gain, residual gain, covariance, and true scores; were compared. A simulation study showed true score analysis produced a large number of Type-I errors. When corrected for this error, this method showed the least power of the four. This outcome was clearly the result of the…
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ERIC Educational Resources Information Center
Thissen, David; Wainer, Howard
Simulation studies of the performance of (potentially) robust statistical estimation produce large quantities of numbers in the form of performance indices of the various estimators under various conditions. This report presents a multivariate graphical display used to aid in the digestion of the plentiful results in a current study of Item…
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Supporting the education evidence portal via text mining
Ananiadou, Sophia; Thompson, Paul; Thomas, James; Mu, Tingting; Oliver, Sandy; Rickinson, Mark; Sasaki, Yutaka; Weissenbacher, Davy; McNaught, John
2010-01-01
The UK Education Evidence Portal (eep) provides a single, searchable, point of access to the contents of the websites of 33 organizations relating to education, with the aim of revolutionizing work practices for the education community. Use of the portal alleviates the need to spend time searching multiple resources to find relevant information. However, the combined content of the websites of interest is still very large (over 500 000 documents and growing). This means that searches using the portal can produce very large numbers of hits. As users often have limited time, they would benefit from enhanced methods of performing searches and viewing results, allowing them to drill down to information of interest more efficiently, without having to sift through potentially long lists of irrelevant documents. The Joint Information Systems Committee (JISC)-funded ASSIST project has produced a prototype web interface to demonstrate the applicability of integrating a number of text-mining tools and methods into the eep, to facilitate an enhanced searching, browsing and document-viewing experience. New features include automatic classification of documents according to a taxonomy, automatic clustering of search results according to similar document content, and automatic identification and highlighting of key terms within documents. PMID:20643679
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Ethanol modulation of gene networks: implications for alcoholism.
Farris, Sean P; Miles, Michael F
2012-01-01
Alcoholism is a complex disease caused by a confluence of environmental and genetic factors influencing multiple brain pathways to produce a variety of behavioral sequelae, including addiction. Genetic factors contribute to over 50% of the risk for alcoholism and recent evidence points to a large number of genes with small effect sizes as the likely molecular basis for this disease. Recent progress in genomics (microarrays or RNA-Seq) and genetics has led to the identification of a large number of potential candidate genes influencing ethanol behaviors or alcoholism itself. To organize this complex information, investigators have begun to focus on the contribution of gene networks, rather than individual genes, for various ethanol-induced behaviors in animal models or behavioral endophenotypes comprising alcoholism. This chapter reviews some of the methods used for constructing gene networks from genomic data and some of the recent progress made in applying such approaches to the study of the neurobiology of ethanol. We show that rapid technology development in gathering genomic data, together with sophisticated experimental design and a growing collection of analysis tools are producing novel insights for understanding the molecular basis of alcoholism and that such approaches promise new opportunities for therapeutic development. Copyright © 2011 Elsevier Inc. All rights reserved.
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Exploring the large-scale structure of Taylor–Couette turbulence through Large-Eddy Simulations
NASA Astrophysics Data System (ADS)
Ostilla-Mónico, Rodolfo; Zhu, Xiaojue; Verzicco, Roberto
2018-04-01
Large eddy simulations (LES) of Taylor-Couette (TC) flow, the flow between two co-axial and independently rotating cylinders are performed in an attempt to explore the large-scale axially-pinned structures seen in experiments and simulations. Both static and dynamic LES models are used. The Reynolds number is kept fixed at Re = 3.4 · 104, and the radius ratio η = ri /ro is set to η = 0.909, limiting the effects of curvature and resulting in frictional Reynolds numbers of around Re τ ≈ 500. Four rotation ratios from Rot = ‑0.0909 to Rot = 0.3 are simulated. First, the LES of TC is benchmarked for different rotation ratios. Both the Smagorinsky model with a constant of cs = 0.1 and the dynamic model are found to produce reasonable results for no mean rotation and cyclonic rotation, but deviations increase for increasing rotation. This is attributed to the increasing anisotropic character of the fluctuations. Second, “over-damped” LES, i.e. LES with a large Smagorinsky constant is performed and is shown to reproduce some features of the large-scale structures, even when the near-wall region is not adequately modeled. This shows the potential for using over-damped LES for fast explorations of the parameter space where large-scale structures are found.
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Yamasaki, Maria; Miyagawa, Taku; Toyoda, Hiromi; Khor, Seik-Soon; Koike, Asako; Nitta, Aino; Akiyama, Kumi; Sasaki, Tsukasa; Honda, Yutaka; Honda, Makoto; Tokunaga, Katsushi
2014-05-01
In humans, narcolepsy with cataplexy (narcolepsy) is a sleep disorder that is characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities. Narcolepsy is caused by a reduction in the number of neurons that produce hypocretin (orexin) neuropeptide. Both genetic and environmental factors contribute to the development of narcolepsy.Rare and large copy number variations (CNVs) reportedly play a role in the etiology of a number of neuropsychiatric disorders. Narcolepsy is considered a neurological disorder; therefore, we sought to investigate any possible association between rare and large CNVs and human narcolepsy. We used DNA microarray data and a CNV detection software application, PennCNV-Affy, to detect CNVs in 426 Japanese narcoleptic patients and 562 healthy individuals. Overall, we found a significant enrichment of rare and large CNVs (frequency ≤1%, size ≥100 kb) in the patients (case-control ratio of CNV count=1.54, P=5.00 × 10(-4)). Next, we extended a region-based association analysis by including CNVs with its size ≥30 kb. Rare and large CNVs in PARK2 region showed a significant association with narcolepsy. Four patients were assessed to carry duplications of the gene region, whereas no controls carried the duplication, which was further confirmed by quantitative PCR assay. This duplication was also found in 2 essential hypersomnia (EHS) patients out of 171 patients. Furthermore, a pathway analysis revealed enrichments of gene disruptions by rare and large CNVs in immune response, acetyltransferase activity, cell cycle regulation and regulation of cell development. This study constitutes the first report on the risk association between multiple rare and large CNVs and the pathogenesis of narcolepsy. In the future, replication studies are needed to confirm the associations.
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Supersonic aerodynamic characteristics of a circular body Earth-to-Orbit vehicle
NASA Technical Reports Server (NTRS)
Ware, George M.; Engelund, Walter C.; Macconochie, Ian O.
1994-01-01
The circular body configuration is a generic single- or multi-stage reusable Earth-to-orbit transport. A thick clipped-delta wing is the major lifting surface. For directional control, three different vertical fin arrangements were investigated: a conventional aft-mounted center fin, wingtip fins, and a nose-mounted fin. The tests were conducted in the Langley Unitary Plan Wind Tunnel. The configuration is longitudinally stable about the estimated center of gravity of 0.72 body length up to a Mach number of about 3.0. Above Mach 3.0, the model is longitudinally unstable at low angles of attack but has a stable secondary trim point at angles of attack above 30 deg. The model has sufficient pitch control authority with elevator and body flap to produce stable trim over the test range. The model with the center fin is directionally stable at low angles of attack up to a Mach number of 3.90. The rudder-like surfaces on the tip fins and the all-movable nose fin are designed as active controls to produce artificial directional stability and are effective in producing yawing moment. The wing trailing-edge aileron surfaces are effective in producing rolling moment, but they also produce large adverse yawing moment.
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LeBlanc Renaud, Susan; Pick, Frances R.; Fortin, Nathalie
2011-01-01
In aquatic ecosystems, the factors that regulate the dominance of toxin-producing cyanobacteria over non-toxin-producing strains of the same species are largely unknown. One possible hypothesis is that limiting resources lead to the dominance of the latter because of the metabolic costs associated with toxin production. In this study, we tested the effect of light intensity on the performance of a microcystin-producing strain of Microcystis aeruginosa (UTCC 300) when grown in mixed cultures with non-microcystin-producing strains with similar intrinsic growth rates (UTCC 632 and UTCC 633). The endpoints measured included culture growth rates, microcystin concentrations and composition, and mcyD gene copy numbers determined using quantitative PCR (Q-PCR). In contrast to the predicted results, under conditions of low light intensity (20 μmol·m−2·s−1), the toxigenic strain became dominant in both of the mixed cultures based on gene copy numbers and microcystin concentrations. When grown under conditions of high light intensity (80 μmol·m−2·s−1), the toxigenic strain still appeared to dominate over nontoxigenic strain UTCC 632 but less so over strain UTCC 633. Microcystins may not be so costly to produce that toxigenic cyanobacteria are at a disadvantage in competition for limiting resources. PMID:21841026
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A generator for unique quantum random numbers based on vacuum states
NASA Astrophysics Data System (ADS)
Gabriel, Christian; Wittmann, Christoffer; Sych, Denis; Dong, Ruifang; Mauerer, Wolfgang; Andersen, Ulrik L.; Marquardt, Christoph; Leuchs, Gerd
2010-10-01
Random numbers are a valuable component in diverse applications that range from simulations over gambling to cryptography. The quest for true randomness in these applications has engendered a large variety of different proposals for producing random numbers based on the foundational unpredictability of quantum mechanics. However, most approaches do not consider that a potential adversary could have knowledge about the generated numbers, so the numbers are not verifiably random and unique. Here we present a simple experimental setup based on homodyne measurements that uses the purity of a continuous-variable quantum vacuum state to generate unique random numbers. We use the intrinsic randomness in measuring the quadratures of a mode in the lowest energy vacuum state, which cannot be correlated to any other state. The simplicity of our source, combined with its verifiably unique randomness, are important attributes for achieving high-reliability, high-speed and low-cost quantum random number generators.
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Targeted Removal of Ant Colonies in Ecological Experiments, Using Hot Water
Tschinkel, Walter R.; King, Joshua R.
2007-01-01
Ecological experiments on fire ants cannot, or should not, use poison baits to eliminate the fire ants because such baits are not specific to fire ants, or even to ants. Hot water is an extremely effective and specific killing agent for fire ant colonies, but producing large amounts of hot water in the field, and making the production apparatus mobile have been problematical. The construction and use of a charcoal-fired kiln made from a 55-gal. oil drum lined with a sand-fireclay mixture is described. An automobile heater fan powered from a 12-v battery provided a draft. Dual bilge pumps pumped water from a large tank through a long coil of copper tubing within the kiln to produce 4 to 5 l. of hot water per min. The hot water was collected in 20 l. buckets and poured into fire ant nests previously opened by piercing with a stick. The entire assembly was transported in and operated from the back of a pickup truck. Five experimental plots containing 32 to 38 colonies of the fire ant, Solenopsis invicta, Buren (Hymenoptera: Formicidae), were treated with hot water over a period of two years. All colonies on the treatment plots were treated twice with hot water early in 2004, reducing their numbers to zero. However new colonies were formed, and mature colonies expanded into the plots. A third treatment was made in the spring of 2005, after which fire ant populations were suppressed for over a year. Whereas the 5 control plots contained a total of 166 mostly large colonies, the 5 treatment plots contained no live colonies at all. Averaged over a two-year period, a 70% reduction in total number of colonies was achieved (P < 0.001) on the treatment plots, and a 93% reduction of large, mature colonies. Over this same time span, the number of colonies in control plots remained stable. The reduction in colony numbers on the treatment plots was reflected in the pitfall trap samples that recorded a 60% reduction in fire ants. PMID:20233079
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Targeted removal of ant colonies in ecological experiments, using hot water.
Tschinkel, Walter R; King, Joshua R
2007-01-01
Ecological experiments on fire ants cannot, or should not, use poison baits to eliminate the fire ants because such baits are not specific to fire ants, or even to ants. Hot water is an extremely effective and specific killing agent for fire ant colonies, but producing large amounts of hot water in the field, and making the production apparatus mobile have been problematical. The construction and use of a charcoal-fired kiln made from a 55-gal. oil drum lined with a sand-fireclay mixture is described. An automobile heater fan powered from a 12-v battery provided a draft. Dual bilge pumps pumped water from a large tank through a long coil of copper tubing within the kiln to produce 4 to 5 l. of hot water per min. The hot water was collected in 20 l. buckets and poured into fire ant nests previously opened by piercing with a stick. The entire assembly was transported in and operated from the back of a pickup truck. Five experimental plots containing 32 to 38 colonies of the fire ant, Solenopsis invicta, Buren (Hymenoptera: Formicidae), were treated with hot water over a period of two years. All colonies on the treatment plots were treated twice with hot water early in 2004, reducing their numbers to zero. However new colonies were formed, and mature colonies expanded into the plots. A third treatment was made in the spring of 2005, after which fire ant populations were suppressed for over a year. Whereas the 5 control plots contained a total of 166 mostly large colonies, the 5 treatment plots contained no live colonies at all. Averaged over a two-year period, a 70% reduction in total number of colonies was achieved (P < 0.001) on the treatment plots, and a 93% reduction of large, mature colonies. Over this same time span, the number of colonies in control plots remained stable. The reduction in colony numbers on the treatment plots was reflected in the pitfall trap samples that recorded a 60% reduction in fire ants.
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Broyles, Steven B; Wyatt, Robert
1995-02-01
The evolution of large floral displays in hermaphroditic flowering plants has been attributed to natural selection acting to enhance male, rather than female, reproductive success. Proponents of the "pollen-donation hypothesis" have assumed that maternal resources, rather than levels of effective pollination, limit fruit set. We investigated the pollen-donation hypothesis in an experimental population of poke milkweed, Asclepias exaltata, where effective pollination did not limit fruit set. Specifically, we examined the effects of flower number per plant, and flower number per umbel on male reproductive success (number of fruits sired) and female reproductive success (number of fruits matured). In 1990, a paternity analysis was performed on fruits collected from 53 plants whose inflorescences were not manipulated. Flower number per plant was significantly correlated with male success, but not with plant gender. Flower number per plant was also significantly correlated with female success, but umbel number and stem number per plant together explained more than half (58%) the variation in female success. The percentage of fruit set was not significantly correlated with flower number per plant. Plants with large floral displays did not disproportionately increase in male reproductive success, relative to female success, as predicted by the pollen-donation hypothesis. In 1991, the effect of flower number per umbel on male and female reproductive success was investigated. Flower number per umbel was manipulated on four umbels per plant by removing flowers to leave 6, 12, or 18 flowers in each umbel. Plants with the largest umbels effectively pollinated twice as many flowers on other plants, but produced only 1.35 times as many fruits as plants with 6 and 12 flowers per umbel. Relative maleness of plants with large umbels was nearly twice that of small and medium umbels. Although these observations are consistent with the pollen-donation hypothesis at the level of umbels, they are problematic, because much of the variation in flower number per umbel exists within, rather than among, plants in natural populations. Thus, plants consist of both reproductively male (large) and female (small) inflorescences, which act to increase total reproductive success. It is therefore inappropriate to explain the evolution of large floral displays in milkweeds solely in terms of potential male reproductive success. © 1995 The Society for the Study of Evolution.
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He, Hongbin; Argiro, Laurent; Dessein, Helia; Chevillard, Christophe
2007-01-01
FTA technology is a novel method designed to simplify the collection, shipment, archiving and purification of nucleic acids from a wide variety of biological sources. The number of punches that can normally be obtained from a single specimen card are often however, insufficient for the testing of the large numbers of loci required to identify genetic factors that control human susceptibility or resistance to multifactorial diseases. In this study, we propose an improved technique to perform large-scale SNP genotyping. We applied a whole genome amplification method to amplify DNA from buccal cell samples stabilized using FTA technology. The results show that using the improved technique it is possible to perform up to 15,000 genotypes from one buccal cell sample. Furthermore, the procedure is simple. We consider this improved technique to be a promising methods for performing large-scale SNP genotyping because the FTA technology simplifies the collection, shipment, archiving and purification of DNA, while whole genome amplification of FTA card bound DNA produces sufficient material for the determination of thousands of SNP genotypes.
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Geomorphic analysis of large alluvial rivers
NASA Astrophysics Data System (ADS)
Thorne, Colin R.
2002-05-01
Geomorphic analysis of a large river presents particular challenges and requires a systematic and organised approach because of the spatial scale and system complexity involved. This paper presents a framework and blueprint for geomorphic studies of large rivers developed in the course of basic, strategic and project-related investigations of a number of large rivers. The framework demonstrates the need to begin geomorphic studies early in the pre-feasibility stage of a river project and carry them through to implementation and post-project appraisal. The blueprint breaks down the multi-layered and multi-scaled complexity of a comprehensive geomorphic study into a number of well-defined and semi-independent topics, each of which can be performed separately to produce a clearly defined, deliverable product. Geomorphology increasingly plays a central role in multi-disciplinary river research and the importance of effective quality assurance makes it essential that audit trails and quality checks are hard-wired into study design. The structured approach presented here provides output products and production trails that can be rigorously audited, ensuring that the results of a geomorphic study can stand up to the closest scrutiny.
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Sosson, Charlotte; Georges, Carrie; Guillaume, Mathieu; Schuller, Anne-Marie; Schiltz, Christine
2018-01-01
Numbers are thought to be spatially organized along a left-to-right horizontal axis with small/large numbers on its left/right respectively. Behavioral evidence for this mental number line (MNL) comes from studies showing that the reallocation of spatial attention by active left/right head rotation facilitated the generation of small/large numbers respectively. While spatial biases in random number generation (RNG) during active movement are well established in adults, comparable evidence in children is lacking and it remains unclear whether and how children’s access to the MNL is affected by active head rotation. To get a better understanding of the development of embodied number processing, we investigated the effect of active head rotation on the mean of generated numbers as well as the mean difference between each number and its immediately preceding response (the first order difference; FOD) not only in adults (n = 24), but also in 7- to 11-year-old elementary school children (n = 70). Since the sign and absolute value of FODs carry distinct information regarding spatial attention shifts along the MNL, namely their direction (left/right) and size (narrow/wide) respectively, we additionally assessed the influence of rotation on the total of negative and positive FODs regardless of their numerical values as well as on their absolute values. In line with previous studies, adults produced on average smaller numbers and generated smaller mean FODs during left than right rotation. More concretely, they produced more negative/positive FODs during left/right rotation respectively and the size of negative FODs was larger (in terms of absolute value) during left than right rotation. Importantly, as opposed to adults, no significant differences in RNG between left and right head rotations were observed in children. Potential explanations for such age-related changes in the effect of active head rotation on RNG are discussed. Altogether, the present study confirms that numerical processing is spatially grounded in adults and suggests that its embodied aspect undergoes significant developmental changes. PMID:29541048
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Two-Dimensional Simulations of Electron Shock Ignition at the Megajoule Scale
NASA Astrophysics Data System (ADS)
Shang, W.; Betti, R.
2016-10-01
Shock ignition uses a late strong shock to ignite the hot spot of an inertial confinement fusion capsule. In the standard shock-ignition scheme, an ignitor shock is launched by the ablation pressure from a spike in laser intensity. Recent experiments on OMEGA have shown that focused beams with intensity up to 6 ×1015 W /cm2 can produce copious amounts of hot electrons. The hot electrons are produced by laser-plasma instabilities (LPI's) and can carry up to 15 % of the instantaneous laser power. Megajoule-scale targets will likely produce even more hot electrons because of the large plasma scale length. We show that it is possible to design ignition targets with low implosion velocities that can be shock ignited using LPI-generated hot electrons to obtain high energy gains. These designs are robust to low-mode asymmetries and they ignite even for highly distorted implosions. Electron shock ignition requires tens of kilojoules of hot electrons, which can only be produced on a large laser facility like the National Ignition Facility. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.
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Experiments on water/melt explosions, nature of products, and models of dispersal
NASA Technical Reports Server (NTRS)
Sheridan, M. F.; Wohletz, K. H.
1984-01-01
Experiments were carried out in a steel pressure device using controlled amounts of water and thermite melt to examine the mechanical energy released on explosive mixing following the initial contact of the two materials. An experimental design was used to allow the direct calculation of the mechanical energy by the dynamic lift of the device as recorded both optically and physically. A large number of experiments were run to accurately determine the optimum mixture of water and melt for the conversion of thermal to mechanical energy. The maximum efficiency observed was about 12% at a water/thermite mass ratio of 0.50. These experiments are the basis for the development of models of hydroexplosions and melt fragmentation. Particles collected from the experimental products are similar in size and shape to pyroclasts produced by much larger hydrovolcanic explosions. Melt rupture at optimum ratios produces very fine particles whereas rupture at high or low water/melt ratios produces large melt fragments. Grain surface textures in the experimental products are also related to the water/melt ratio and the mechanism of explosive mixing. It is thus possible to have qualitative information about the nature of the explosion from the sizes and shapes of the fragments produced.
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Large-pitch steerable synthetic transmit aperture imaging (LPSSTA)
NASA Astrophysics Data System (ADS)
Li, Ying; Kolios, Michael C.; Xu, Yuan
2016-04-01
A linear ultrasound array system usually has a larger pitch and is less costly than a phased array system, but loses the ability to fully steer the ultrasound beam. In this paper, we propose a system whose hardware is similar to a large-pitch linear array system, but whose ability to steer the beam is similar to a phased array system. The motivation is to reduce the total number of measurement channels M (the product of the number of transmissions, nT, and the number of the receive channels in each transmission, nR), while maintaining reasonable image quality. We combined adjacent elements (with proper delays introduced) into groups that would be used in both the transmit and receive processes of synthetic transmit aperture imaging. After the M channels of RF data were acquired, a pseudo-inversion was applied to estimate the equivalent signal in traditional STA to reconstruct a STA image. Even with the similar M, different choices of nT and nR will produce different image quality. The images produced with M=N2/15 in the selected regions of interest (ROI) were demonstrated to be comparable with a full phased array, where N is the number of the array elements. The disadvantage of the proposed system is that its field of view in one delay-configuration is smaller than a standard full phased array. However, by adjusting the delay for each element within each group, the beam can be steered to cover the same field of view as the standard fully-filled phased array. The LPSSTA system might be useful for 3D ultrasound imaging.
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On the scaling of small-scale jet noise to large scale
NASA Technical Reports Server (NTRS)
Soderman, Paul T.; Allen, Christopher S.
1992-01-01
An examination was made of several published jet noise studies for the purpose of evaluating scale effects important to the simulation of jet aeroacoustics. Several studies confirmed that small conical jets, one as small as 59 mm diameter, could be used to correctly simulate the overall or perceived noise level (PNL) noise of large jets dominated by mixing noise. However, the detailed acoustic spectra of large jets are more difficult to simulate because of the lack of broad-band turbulence spectra in small jets. One study indicated that a jet Reynolds number of 5 x 10(exp 6) based on exhaust diameter enabled the generation of broad-band noise representative of large jet mixing noise. Jet suppressor aeroacoustics is even more difficult to simulate at small scale because of the small mixer nozzles with flows sensitive to Reynolds number. Likewise, one study showed incorrect ejector mixing and entrainment using a small-scale, short ejector that led to poor acoustic scaling. Conversely, fairly good results were found with a longer ejector and, in a different study, with a 32-chute suppressor nozzle. Finally, it was found that small-scale aeroacoustic resonance produced by jets impacting ground boards does not reproduce at large scale.
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On the scaling of small-scale jet noise to large scale
NASA Technical Reports Server (NTRS)
Soderman, Paul T.; Allen, Christopher S.
1992-01-01
An examination was made of several published jet noise studies for the purpose of evaluating scale effects important to the simulation of jet aeroacoustics. Several studies confirmed that small conical jets, one as small as 59 mm diameter, could be used to correctly simulate the overall or PNL noise of large jets dominated by mixing noise. However, the detailed acoustic spectra of large jets are more difficult to simulate because of the lack of broad-band turbulence spectra in small jets. One study indicated that a jet Reynolds number of 5 x 10 exp 6 based on exhaust diameter enabled the generation of broad-band noise representative of large jet mixing noise. Jet suppressor aeroacoustics is even more difficult to simulate at small scale because of the small mixer nozzles with flows sensitive to Reynolds number. Likewise, one study showed incorrect ejector mixing and entrainment using small-scale, short ejector that led to poor acoustic scaling. Conversely, fairly good results were found with a longer ejector and, in a different study, with a 32-chute suppressor nozzle. Finally, it was found that small-scale aeroacoustic resonance produced by jets impacting ground boards does not reproduce at large scale.
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Structure-toxicity relationships of acrylic monomers.
Autian, J
1975-01-01
Esters of acrylic acid, in particular methyl methacrylate, have wide applications in a number of industrial and consumer products, forming very desirable nonbreakable glass-like materials. In dentistry, the monomers are used to prepare dentures and a variety of filling and coating materials for the teeth. Surgeons utilize the monomers to prepare a cement which helps anchor prosthetic devices to bone. Special types of acrylic monomers such as the cyano derivatives have found a useful application as adhesive materials. Most of the acrylic acid esters are volatile substances and can produce various levels of toxicity if inhaled. A large number of workers thus exposed to the vapors of these esters can develop clinical symptoms and signs of toxicity. This paper will discuss the toxicity of a large number of acrylic esters, and will attempt to show structure-activity relationships where such data are available. General comments will also be made as to the potential health hazards this variety of esters may present to selected segments of the population. PMID:1175551
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Structure-toxicity relationships of acrylic monomers.
Autian, J
1975-06-01
Esters of acrylic acid, in particular methyl methacrylate, have wide applications in a number of industrial and consumer products, forming very desirable nonbreakable glass-like materials. In dentistry, the monomers are used to prepare dentures and a variety of filling and coating materials for the teeth. Surgeons utilize the monomers to prepare a cement which helps anchor prosthetic devices to bone. Special types of acrylic monomers such as the cyano derivatives have found a useful application as adhesive materials. Most of the acrylic acid esters are volatile substances and can produce various levels of toxicity if inhaled. A large number of workers thus exposed to the vapors of these esters can develop clinical symptoms and signs of toxicity. This paper will discuss the toxicity of a large number of acrylic esters, and will attempt to show structure-activity relationships where such data are available. General comments will also be made as to the potential health hazards this variety of esters may present to selected segments of the population.
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Statistical Surrogate Modeling of Atmospheric Dispersion Events Using Bayesian Adaptive Splines
NASA Astrophysics Data System (ADS)
Francom, D.; Sansó, B.; Bulaevskaya, V.; Lucas, D. D.
2016-12-01
Uncertainty in the inputs of complex computer models, including atmospheric dispersion and transport codes, is often assessed via statistical surrogate models. Surrogate models are computationally efficient statistical approximations of expensive computer models that enable uncertainty analysis. We introduce Bayesian adaptive spline methods for producing surrogate models that capture the major spatiotemporal patterns of the parent model, while satisfying all the necessities of flexibility, accuracy and computational feasibility. We present novel methodological and computational approaches motivated by a controlled atmospheric tracer release experiment conducted at the Diablo Canyon nuclear power plant in California. Traditional methods for building statistical surrogate models often do not scale well to experiments with large amounts of data. Our approach is well suited to experiments involving large numbers of model inputs, large numbers of simulations, and functional output for each simulation. Our approach allows us to perform global sensitivity analysis with ease. We also present an approach to calibration of simulators using field data.
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Statistical detection of systematic election irregularities
Klimek, Peter; Yegorov, Yuri; Hanel, Rudolf; Thurner, Stefan
2012-01-01
Democratic societies are built around the principle of free and fair elections, and that each citizen’s vote should count equally. National elections can be regarded as large-scale social experiments, where people are grouped into usually large numbers of electoral districts and vote according to their preferences. The large number of samples implies statistical consequences for the polling results, which can be used to identify election irregularities. Using a suitable data representation, we find that vote distributions of elections with alleged fraud show a kurtosis substantially exceeding the kurtosis of normal elections, depending on the level of data aggregation. As an example, we show that reported irregularities in recent Russian elections are, indeed, well-explained by systematic ballot stuffing. We develop a parametric model quantifying the extent to which fraudulent mechanisms are present. We formulate a parametric test detecting these statistical properties in election results. Remarkably, this technique produces robust outcomes with respect to the resolution of the data and therefore, allows for cross-country comparisons. PMID:23010929
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Statistical detection of systematic election irregularities.
Klimek, Peter; Yegorov, Yuri; Hanel, Rudolf; Thurner, Stefan
2012-10-09
Democratic societies are built around the principle of free and fair elections, and that each citizen's vote should count equally. National elections can be regarded as large-scale social experiments, where people are grouped into usually large numbers of electoral districts and vote according to their preferences. The large number of samples implies statistical consequences for the polling results, which can be used to identify election irregularities. Using a suitable data representation, we find that vote distributions of elections with alleged fraud show a kurtosis substantially exceeding the kurtosis of normal elections, depending on the level of data aggregation. As an example, we show that reported irregularities in recent Russian elections are, indeed, well-explained by systematic ballot stuffing. We develop a parametric model quantifying the extent to which fraudulent mechanisms are present. We formulate a parametric test detecting these statistical properties in election results. Remarkably, this technique produces robust outcomes with respect to the resolution of the data and therefore, allows for cross-country comparisons.
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Snodgrass, G L; Jackson, R E; Abel, C A; Perera, O P
2010-08-01
Commercially produced maturity group (MG) IV soybeans, Glycine max L., were sampled during bloom for tarnished plant bugs, Lygus lineolaris (Palisot de Beauvois), during May and June 1999 (3 fields) and 2001 (18 fields). The adults and nymphs were found primarily in single population peaks in both years, indicating a single new generation was produced during each year. The peak mean numbers of nymphs were 0.61 and 0.84 per drop cloth sample in 1999 and 2001, respectively. Adults peaked at 3.96 (1999) and 3.76 (2001) per sweep net sample (25 sweeps). Tests using laboratory-reared and field-collected tarnished plant bugs resulted in very poor survival of nymphs on 16 different soybean varieties (MG III, one; IV, four; V, nine; VI, two). A large cage (0.06 ha) field test found that the number of nymphs produced on eight soybean varieties after mated adults were released into the cages was lower than could be expected on a suitable host. These results indicated that soybean was a marginal host for tarnished plant bugs. However, the numbers of adults and nymphs found in the commercially produced fields sampled in the study may have been high enough to cause feeding damage to the flowering soybeans. The nature of the damage and its possible economic importance were not determined. Reproduction of tarnished plant bugs in the commercially produced early soybean fields showed that the early soybeans provided tarnished plant bugs with a very abundant host at a time when only wild hosts were previously available.
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Gunderson, Elizabeth A; Levine, Susan C
2011-09-01
Before they enter preschool, children vary greatly in their numerical and mathematical knowledge, and this knowledge predicts their achievement throughout elementary school (e.g. Duncan et al., 2007; Ginsburg & Russell, 1981). Therefore, it is critical that we look to the home environment for parental inputs that may lead to these early variations. Recent work has shown that the amount of number talk that parents engage in with their children is robustly related to a critical aspect of mathematical development - cardinal-number knowledge (e.g. knowing that the word 'three' refers to sets of three entities; Levine, Suriyakham, Rowe, Huttenlocher & Gunderson, 2010). The present study characterizes the different types of number talk that parents produce and investigates which types are most predictive of children's later cardinal-number knowledge. We find that parents' number talk involving counting or labeling sets of present, visible objects is related to children's later cardinal-number knowledge, whereas other types of parent number talk are not. In addition, number talk that refers to large sets of present objects (i.e. sets of size 4 to 10 that fall outside children's ability to track individual objects) is more robustly predictive of children's later cardinal-number knowledge than talk about smaller sets. The relation between parents' number talk about large sets of present objects and children's cardinal-number knowledge remains significant even when controlling for factors such as parents' socioeconomic status and other measures of parents' number and non-number talk. © 2011 Blackwell Publishing Ltd.
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Hays, G C
2000-09-21
Sea turtles nest on sandy beaches and tend to show high fidelity to specific nesting areas, but, despite this fidelity, the inter-annual variation in nesting numbers may be large. This variation may reflect the fact that turtles do not usually nest in consecutive years. Here, theoretical models are developed in which the interval between successive nesting years (the remigration interval) reflects conditions encountered on the feeding grounds, with good feeding years leading to a reduction in the remigration interval and vice versa. These simple models produce high levels of inter-annual variation in nesting numbers with, on occasion, almost no turtles nesting in some years even when the population is large and stable. The implications for assessing the size of sea turtle populations are considered. Copyright 2000 Academic Press.
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Distributed magnetic field positioning system using code division multiple access
NASA Technical Reports Server (NTRS)
Prigge, Eric A. (Inventor)
2003-01-01
An apparatus and methods for a magnetic field positioning system use a fundamentally different, and advantageous, signal structure and multiple access method, known as Code Division Multiple Access (CDMA). This signal architecture, when combined with processing methods, leads to advantages over the existing technologies, especially when applied to a system with a large number of magnetic field generators (beacons). Beacons at known positions generate coded magnetic fields, and a magnetic sensor measures a sum field and decomposes it into component fields to determine the sensor position and orientation. The apparatus and methods can have a large `building-sized` coverage area. The system allows for numerous beacons to be distributed throughout an area at a number of different locations. A method to estimate position and attitude, with no prior knowledge, uses dipole fields produced by these beacons in different locations.
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Low energy atmospheric muon neutrinos in MACRO
NASA Astrophysics Data System (ADS)
Ambrosio, M.; Antolini, R.; Auriemma, G.; Bakari, D.; Baldini, A.; Barbarino, G. C.; Barish, B. C.; Battistoni, G.; Bellotti, R.; Bemporad, C.; Bernardini, P.; Bilokon, H.; Bisi, V.; Bloise, C.; Bower, C.; Brigida, M.; Bussino, S.; Cafagna, F.; Calicchio, M.; Campana, D.; Carboni, M.; Cecchini, S.; Cei, F.; Chiarella, V.; Choudhary, B. C.; Coutu, S.; De Cataldo, G.; Dekhissi, H.; De Marzo, C.; De Mitri, I.; Derkaoui, J.; De Vincenzi, M.; Di Credico, A.; Erriquez, O.; Favuzzi, C.; Forti, C.; Fusco, P.; Giacomelli, G.; Giannini, G.; Giglietto, N.; Giorgini, M.; Grassi, M.; Gray, L.; Grillo, A.; Guarino, F.; Gustavino, C.; Habig, A.; Hanson, K.; Heinz, R.; Iarocci, E.; Katsavounidis, E.; Katsavounidis, I.; Kearns, E.; Kim, H.; Kyriazopoulou, S.; Lamanna, E.; Lane, C.; Levin, D. S.; Lipari, P.; Longley, N. P.; Longo, M. J.; Loparco, F.; Maaroufi, F.; Mancarella, G.; Mandrioli, G.; Margiotta, A.; Marini, A.; Martello, D.; Marzari-Chiesa, A.; Mazziotta, M. N.; Michael, D. G.; Mikheyev, S.; Miller, L.; Monacelli, P.; Montaruli, T.; Monteno, M.; Mufson, S.; Musser, J.; Nicolò, D.; Nolty, R.; Orth, C.; Osteria, G.; Ouchrif, M.; Palamara, O.; Patera, V.; Patrizii, L.; Pazzi, R.; Peck, C. W.; Perrone, L.; Petrera, S.; Pistilli, P.; Popa, V.; Rainò, A.; Reynoldson, J.; Ronga, F.; Satriano, C.; Satta, L.; Scapparone, E.; Scholberg, K.; Sciubba, A.; Serra, P.; Sioli, M.; Sirri, G.; Sitta, M.; Spinelli, P.; Spinetti, M.; Spurio, M.; Steinberg, R.; Stone, J. L.; Sulak, L. R.; Surdo, A.; Tarlè, G.; Togo, V.; Vakili, M.; Vilela, E.; Walter, C. W.; Webb, R.
2000-04-01
We present the measurement of two event samples induced by atmospheric νμ of average energy
Eoverlineν~4 GeV. In the first sample, a neutrino interacts inside the MACRO detector producing an upward-going muon leaving the apparatus. The ratio of the number of observed to expected events is 0.57+/-0.05stat+/-0.06syst+/-0.14theor with an angular distribution similar to that expected from the Bartol atmospheric neutrino flux. The second is a mixed sample of internally produced downward-going muons and externally produced upward-going muons stopping inside the detector. These two subsamples are selected by topological criteria; the lack of timing information makes it impossible to distinguish stopping from downgoing muons. The ratio of the number of observed to expected events is 0.71+/-0.05stat+/-0.07syst+/-0.18theor. The observed deficits in each subsample is in agreement with neutrino oscillations, although the significance is reduced by the large theoretical errors. However, the ratio of the two samples causes a large cancellation of theoretical and of some systematic errors. With the ratio, we rule out the no-oscillation hypothesis at 95% c.l. Furthermore, the ratio tests the pathlength dependence of possible oscillations. The data of both samples and their ratio favor maximal mixing and Δm2~10-3-10-2 eV2. These parameters are in agreement with our results from upward throughgoing muons, induced by νμ of much higher energies. -
Rutter, J M; Beer, R J
1975-02-01
The role of the microbial flora of the large intestine in experimental Trichuris suis infection was studied by comparing the clinical syndrome in conventionally reared (CR) pigs, specific pathogen-free pigs, and gnotobiotic pigs. Thedisease in CR pigs was characterized by a severe mucohemorrhagic enteritis; in contrast, a mild catarrhal enteritis was observed in specific pathogen-free and gnotobiotic pigs. Spirochaetes and vibrio-like organisms were observed only in CR pigs and increased during the clinical phase of the disease. The clinical syndrome was not transmitted by oral administration of intestinal or fecal material from infected CR pigs to CR pigs free of T. suis. Smaller numbers of T. suis produced diarrhea in CR pigs and significantly reduced the growth rates of infected animals; clinical signs and the reduction in growth rate was prevented by incorporating an antibacterial substance (dimetridazole) in the food. Although clinical trichuriasis closely resembles swin dysentery, the two syndromes seem to be distinct. The present results suggest that a microbial component acts synergistically with T. suis to produce the severe clinical syndrome in CR pigs, but identification of the microbial component and the mechanism by which clinical signs are produced await further studies of the bacterial flora of the large intestine of pigs.
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1972-02-01
The Apollo Telescope Mount (ATM) was designed and developed by the Marshall Space Flight Center and served as the primary scientific instrument unit aboard Skylab (1973-1979). The ATM consisted of eight scientific instruments as well as a number of smaller experiments. In this image, the set of four large solar cell arrays, which could produce up to as much as 1.1 kilowatts of electric power, are being installed on an ATM prototype.
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Significant Science at Jupiter Using Solar Power
NASA Technical Reports Server (NTRS)
Reitsema, H. J.; Smith, E. J.; Spilker, T.; Reinert, R.
2001-01-01
Missions to the Outer Planets are challenging for a number of reasons, primary of which is the low output of solar arrays at large heliocentric distances. The INSIDE Jupiter mission is a Discovery concept for a science investigation at Jupiter that is capable of producing major studies of the Jovian internal structure and ionospheric-magnetospheric coupling. Additional information is contained in the original extended abstract.
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Assessing wood quality of borer-infested red oak logs with a resonance acoustic technique
Xiping Wang; Henry E. Stelzer; Jan Wiedenbeck; Patricia K. Lebow; Robert J. Ross
2009-01-01
Large numbers of black oak (Quercus velutina Lam.) and scarlet oak (Quercus coccinea Muenchh.) trees are declining and dying in the Missouri Ozark forest as a result of oak decline. Red oak borer-infested trees produce low-grade logs that become extremely difficult to merchandize as the level of insect attack increases. The objective of this study was to investigate...
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ERIC Educational Resources Information Center
Pérez-Hernández, Lorena; Duvignau, Karine
2016-01-01
The present study looks into the largely unexplored territory of the cognitive underpinnings of semantic approximations in child language. The analysis of a corpus of 233 semantic approximations produced by 101 monolingual French-speaking children from 1;8 to 4;2 years of age leads to a classification of a significant number of them as instances…
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Effects of forebody geometry on subsonic boundary-layer stability
NASA Technical Reports Server (NTRS)
Dodbele, Simha S.
1990-01-01
As part of an effort to develop computational techniques for design of natural laminar flow fuselages, a computational study was made of the effect of forebody geometry on laminar boundary layer stability on axisymmetric body shapes. The effects of nose radius on the stability of the incompressible laminar boundary layer was computationally investigated using linear stability theory for body length Reynolds numbers representative of small and medium-sized airplanes. The steepness of the pressure gradient and the value of the minimum pressure (both functions of fineness ratio) govern the stability of laminar flow possible on an axisymmetric body at a given Reynolds number. It was found that to keep the laminar boundary layer stable for extended lengths, it is important to have a small nose radius. However, nose shapes with extremely small nose radii produce large pressure peaks at off-design angles of attack and can produce vortices which would adversely affect transition.
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Optimum Actuator Selection with a Genetic Algorithm for Aircraft Control
NASA Technical Reports Server (NTRS)
Rogers, James L.
2004-01-01
The placement of actuators on a wing determines the control effectiveness of the airplane. One approach to placement maximizes the moments about the pitch, roll, and yaw axes, while minimizing the coupling. For example, the desired actuators produce a pure roll moment without at the same time causing much pitch or yaw. For a typical wing, there is a large set of candidate locations for placing actuators, resulting in a substantially larger number of combinations to examine in order to find an optimum placement satisfying the mission requirements and mission constraints. A genetic algorithm has been developed for finding the best placement for four actuators to produce an uncoupled pitch moment. The genetic algorithm has been extended to find the minimum number of actuators required to provide uncoupled pitch, roll, and yaw control. A simplified, untapered, unswept wing is the model for each application.
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"Silicon millefeuille": From a silicon wafer to multiple thin crystalline films in a single step
NASA Astrophysics Data System (ADS)
Hernández, David; Trifonov, Trifon; Garín, Moisés; Alcubilla, Ramon
2013-04-01
During the last years, many techniques have been developed to obtain thin crystalline films from commercial silicon ingots. Large market applications are foreseen in the photovoltaic field, where important cost reductions are predicted, and also in advanced microelectronics technologies as three-dimensional integration, system on foil, or silicon interposers [Dross et al., Prog. Photovoltaics 20, 770-784 (2012); R. Brendel, Thin Film Crystalline Silicon Solar Cells (Wiley-VCH, Weinheim, Germany 2003); J. N. Burghartz, Ultra-Thin Chip Technology and Applications (Springer Science + Business Media, NY, USA, 2010)]. Existing methods produce "one at a time" silicon layers, once one thin film is obtained, the complete process is repeated to obtain the next layer. Here, we describe a technology that, from a single crystalline silicon wafer, produces a large number of crystalline films with controlled thickness in a single technological step.
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Automated adaptive inference of phenomenological dynamical models.
Daniels, Bryan C; Nemenman, Ilya
2015-08-21
Dynamics of complex systems is often driven by large and intricate networks of microscopic interactions, whose sheer size obfuscates understanding. With limited experimental data, many parameters of such dynamics are unknown, and thus detailed, mechanistic models risk overfitting and making faulty predictions. At the other extreme, simple ad hoc models often miss defining features of the underlying systems. Here we develop an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their complexity to the available data. Such adaptive models produce accurate predictions even when microscopic details are unknown. The approach is computationally tractable, even for a relatively large number of dynamical variables. Using simulated data, it correctly infers the phase space structure for planetary motion, avoids overfitting in a biological signalling system and produces accurate predictions for yeast glycolysis with tens of data points and over half of the interacting species unobserved.
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Direct detection of x-rays for protein crystallography employing a thick, large area CCD
Atac, Muzaffer; McKay, Timothy
1999-01-01
An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.
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Automated adaptive inference of phenomenological dynamical models
Daniels, Bryan C.; Nemenman, Ilya
2015-01-01
Dynamics of complex systems is often driven by large and intricate networks of microscopic interactions, whose sheer size obfuscates understanding. With limited experimental data, many parameters of such dynamics are unknown, and thus detailed, mechanistic models risk overfitting and making faulty predictions. At the other extreme, simple ad hoc models often miss defining features of the underlying systems. Here we develop an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their complexity to the available data. Such adaptive models produce accurate predictions even when microscopic details are unknown. The approach is computationally tractable, even for a relatively large number of dynamical variables. Using simulated data, it correctly infers the phase space structure for planetary motion, avoids overfitting in a biological signalling system and produces accurate predictions for yeast glycolysis with tens of data points and over half of the interacting species unobserved. PMID:26293508
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Barley Transformation Using Agrobacterium-Mediated Techniques
NASA Astrophysics Data System (ADS)
Harwood, Wendy A.; Bartlett, Joanne G.; Alves, Silvia C.; Perry, Matthew; Smedley, Mark A.; Leyland, Nicola; Snape, John W.
Methods for the transformation of barley using Agrobacterium-mediated techniques have been available for the past 10 years. Agrobacterium offers a number of advantages over biolistic-mediated techniques in terms of efficiency and the quality of the transformed plants produced. This chapter describes a simple system for the transformation of barley based on the infection of immature embryos with Agrobacterium tumefaciens followed by the selection of transgenic tissue on media containing the antibiotic hygromycin. The method can lead to the production of large numbers of fertile, independent transgenic lines. It is therefore ideal for studies of gene function in a cereal crop system.
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NASA Technical Reports Server (NTRS)
Strobel, D. F.; Apruzese, J. P.; Schoeberl, M. R.
1985-01-01
The constraints on turbulence improved by the mesospheric heat budget are reexamined, and the sufficiency of the theoretical evidence to support the hypothesis that the eddy Prandtl number is greater than one in the mesosphere is considered. The mesopause thermal structure is calculated with turbulent diffusion coefficients commonly used in chemical models and deduced from mean zonal wind deceleration. It is shown that extreme mesopause temperatures of less than 100 K are produced by the large net cooling. The results demonstrate the importance of the Prandtl number for mesospheric turbulence.
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Scope of Various Random Number Generators in ant System Approach for TSP
NASA Technical Reports Server (NTRS)
Sen, S. K.; Shaykhian, Gholam Ali
2007-01-01
Experimented on heuristic, based on an ant system approach for traveling salesman problem, are several quasi- and pseudo-random number generators. This experiment is to explore if any particular generator is most desirable. Such an experiment on large samples has the potential to rank the performance of the generators for the foregoing heuristic. This is mainly to seek an answer to the controversial issue "which generator is the best in terms of quality of the result (accuracy) as well as cost of producing the result (time/computational complexity) in a probabilistic/statistical sense."
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Power Law Distributions of Patents as Indicators of Innovation
NASA Astrophysics Data System (ADS)
O'Neale, Dion; Hendy, Shaun
2013-03-01
The total number of patents produced by a country (or the number of patents produced per capita) is often used as an indicator for innovation. Such figures however give an overly simplistic measure of innovation within a country. Here we present evidence that the distribution of patents amongst applicants within many countries is well-fitted to a power law distribution with exponents that vary between 1.66 (Japan) and 2.37 (Poland). We suggest that this exponent is a useful new metric for studying innovation. Using simulations based on simple preferential attachment-type rules that generate power laws, we find we can explain some of the variation in exponents between countries, with countries that have larger numbers of patents per applicant generally exhibiting smaller exponents in both the simulated and actual data. Similarly we find that the exponents for most countries are inversely correlated with other indicators of innovation, such as research and development intensity or the ubiquity of export baskets. This suggests that in more advanced economies, which tend to have smaller values of the exponent, a greater proportion of the total number of patents are filed by large companies than in less advanced countries.
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Question 3: The Worlds of the Prebiotic and Never Born Proteins
NASA Astrophysics Data System (ADS)
Chiarabelli, Cristiano; de Lucrezia, Davide
2007-10-01
Starting from the statement that no reliable methods are known to produce high molecular weight polypeptides under prebiotic conditions, a possible approach, at least to understand the differences between extant proteins and the possible large number of never born proteins, could be biological. Using the phage display method a large library of totally random amino acidic sequences was obtained. Consequently, different experiments to directly consider the frequency of stable folds were performed, and the interesting results obtained from such new approach are discussed in terms of contingency, contributing to the discussion on the selection mechanism of extant proteins.
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PLATSIM: An efficient linear simulation and analysis package for large-order flexible systems
NASA Technical Reports Server (NTRS)
Maghami, Periman; Kenny, Sean P.; Giesy, Daniel P.
1995-01-01
PLATSIM is a software package designed to provide efficient time and frequency domain analysis of large-order generic space platforms implemented with any linear time-invariant control system. Time domain analysis provides simulations of the overall spacecraft response levels due to either onboard or external disturbances. The time domain results can then be processed by the jitter analysis module to assess the spacecraft's pointing performance in a computationally efficient manner. The resulting jitter analysis algorithms have produced an increase in speed of several orders of magnitude over the brute force approach of sweeping minima and maxima. Frequency domain analysis produces frequency response functions for uncontrolled and controlled platform configurations. The latter represents an enabling technology for large-order flexible systems. PLATSIM uses a sparse matrix formulation for the spacecraft dynamics model which makes both the time and frequency domain operations quite efficient, particularly when a large number of modes are required to capture the true dynamics of the spacecraft. The package is written in MATLAB script language. A graphical user interface (GUI) is included in the PLATSIM software package. This GUI uses MATLAB's Handle graphics to provide a convenient way for setting simulation and analysis parameters.
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MaRaCluster: A Fragment Rarity Metric for Clustering Fragment Spectra in Shotgun Proteomics.
The, Matthew; Käll, Lukas
2016-03-04
Shotgun proteomics experiments generate large amounts of fragment spectra as primary data, normally with high redundancy between and within experiments. Here, we have devised a clustering technique to identify fragment spectra stemming from the same species of peptide. This is a powerful alternative method to traditional search engines for analyzing spectra, specifically useful for larger scale mass spectrometry studies. As an aid in this process, we propose a distance calculation relying on the rarity of experimental fragment peaks, following the intuition that peaks shared by only a few spectra offer more evidence than peaks shared by a large number of spectra. We used this distance calculation and a complete-linkage scheme to cluster data from a recent large-scale mass spectrometry-based study. The clusterings produced by our method have up to 40% more identified peptides for their consensus spectra compared to those produced by the previous state-of-the-art method. We see that our method would advance the construction of spectral libraries as well as serve as a tool for mining large sets of fragment spectra. The source code and Ubuntu binary packages are available at https://github.com/statisticalbiotechnology/maracluster (under an Apache 2.0 license).
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Plasma focus ion beam-scaling laws
NASA Astrophysics Data System (ADS)
Saw, S. H.
2014-08-01
Measurements on plasma focus ion beams include various advanced techniques producing a variety of data which has yet to produce benchmark numbers. Recent numerical experiments using an extended version of the Lee Code has produced reference numbers and scaling trends for number and energy fluence of deuteron beams as functions of stored energy E0. At the pinch exit the ion number fluence (ions m-2) and energy fluence (J m-2) computed as 2.4-7.8×1020 and 2.2-33×106 respectively were found to be independent of E0 from 0.4 - 486 kJ. This work was extended to the ion beams for various gases. The results show that, for a given plasma focus, the fluence, flux, ion number and ion current decrease from the lightest to the heaviest gas except for trend-breaking higher values for Ar fluence and flux. The energy fluence, energy flux, power flow and damage factors are relatively constant from H2 to N2 but increase for Ne, Ar, Kr and Xe due to radiative cooling and collapse effects. This paper reviews this work and in a concluding section attempts to put the accumulating large amounts of data into the form of a scaling law of beam energy Ebeam versus storage energy E0 taking the form for deuteron as: {Ebeam} = 18.2{E}01.23; where Ebeam is in J and E0 is in kJ. It is hoped that the establishment of such scaling laws places on a firm footing the reference quantitative ideas for plasma focus ion beams.
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Pontes, J H F; Melo Sterza, F A; Basso, A C; Ferreira, C R; Sanches, B V; Rubin, K C P; Seneda, M M
2011-06-01
The objective was to clarify in vitro production of bovine embryos in Brazil. Data from 656 ovum pick-up/in vitro production (OPU/IVP) procedures, performed on 317 Nelore (Bos indicus) donors, without hormone stimulation or control of ovarian follicular waves, were analysed. Donors were subjected to OPU from one to nine times (no specific schedule), with < 15 d between consecutive procedures. There were 20,848 oocytes, of which 15,747 (75.53%) were considered viable, 5,446 embryos were obtained, 5,398 embryos were immediately transferred, resulting in 1,974 pregnancies (36.57%) at Day 30 and 1,788 (33.12%) pregnancies at Day 60. The average number of total and viable oocytes produced per OPU session was (mean ± SEM) 30.84 ± 0.88 and 23.35 ± 0.7 (average of 8.1 ± 0.3 embryos and 3.0 ± 0.1 pregnancies per OPU-IVP procedure). Since oocyte production varied widely among donor, they were designated as very high, high, intermediate, and low, with 58.94 ± 2.04, 32.61 ± 0.50, 22.13 ± 0.50, and 10.26 ± 0.57 oocytes, respectively, produced by 78, 80, 79, and 80 donors. The number of viable oocytes recovered ranged from 0 to 128; since donors with numerous viable oocytes produced many viable embryos and pregnancies, oocyte production was useful for donor selection. However, there was no significant effect of the number of OPU sessions per donor on mean numbers of oocytes produced. In conclusion, we confirmed field reports of high oocyte production by some Nelore donors and demonstrated individual variation in oocyte yield, which was associated with embryo production and pregnancy rates. Copyright © 2011 Elsevier Inc. All rights reserved.
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NASA Astrophysics Data System (ADS)
Rolph, Rebecca J.; Mahoney, Andrew R.; Walsh, John; Loring, Philip A.
2018-05-01
Using thresholds of physical climate variables developed from community observations, together with two large-scale datasets, we have produced local indices directly relevant to the impacts of a reduced sea ice cover on Alaska coastal communities. The indices include the number of false freeze-ups defined by transient exceedances of ice concentration prior to a corresponding exceedance that persists,
false break-ups
, timing of freeze-up and break-up, length of the open water duration, number of days when the winds preclude hunting via boat (wind speed threshold exceedances), the number of wind events conducive to geomorphological work or damage to infrastructure from ocean waves, and the number of these wind events with on- and along-shore components promoting water setup along the coastline. We demonstrate how community observations can inform use of large-scale datasets to derive these locally relevant indices. The two primary large-scale datasets are the Historical Sea Ice Atlas for Alaska and the atmospheric output from a regional climate model used to downscale the ERA-Interim atmospheric reanalysis. We illustrate the variability and trends of these indices by application to the rural Alaska communities of Kotzebue, Shishmaref, and Utqiaġvik (previously Barrow), although the same procedure and metrics can be applied to other coastal communities. Over the 1979-2014 time period, there has been a marked increase in the number of combined false freeze-ups and false break-ups as well as the number of days too windy for hunting via boat for all three communities, especially Utqiaġvik. At Utqiaġvik, there has been an approximate tripling of the number of wind events conducive to coastline erosion from 1979 to 2014. We have also found a delay in freeze-up and earlier break-up, leading to a lengthened open water period for all of the communities examined. -
A Comparative Study of Automated Infrasound Detectors - PMCC and AFD with Analyst Review.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Park, Junghyun; Hayward, Chris; Zeiler, Cleat
Automated detections calculated by the progressive multi-channel correlation (PMCC) method (Cansi, 1995) and the adaptive F detector (AFD) (Arrowsmith et al., 2009) are compared to the signals identified by five independent analysts. Each detector was applied to a four-hour time sequence recorded by the Korean infrasound array CHNAR. This array was used because it is composed of both small (<100 m) and large (~1000 m) aperture element spacing. The four hour time sequence contained a number of easily identified signals under noise conditions that have average RMS amplitudes varied from 1.2 to 4.5 mPa (1 to 5 Hz), estimated withmore » running five-minute window. The effectiveness of the detectors was estimated for the small aperture, large aperture, small aperture combined with the large aperture, and full array. The full and combined arrays performed the best for AFD under all noise conditions while the large aperture array had the poorest performance for both detectors. PMCC produced similar results as AFD under the lower noise conditions, but did not produce as dramatic an increase in detections using the full and combined arrays. Both automated detectors and the analysts produced a decrease in detections under the higher noise conditions. Comparing the detection probabilities with Estimated Receiver Operating Characteristic (EROC) curves we found that the smaller value of consistency for PMCC and the larger p-value for AFD had the highest detection probability. These parameters produced greater changes in detection probability than estimates of the false alarm rate. The detection probability was impacted the most by noise level, with low noise (average RMS amplitude of 1.7 mPa) having an average detection probability of ~40% and high noise (average RMS amplitude of 2.9 mPa) average detection probability of ~23%.« less
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Stochastic Reconnection for Large Magnetic Prandtl Numbers
NASA Astrophysics Data System (ADS)
Jafari, Amir; Vishniac, Ethan T.; Kowal, Grzegorz; Lazarian, Alex
2018-06-01
We consider stochastic magnetic reconnection in high-β plasmas with large magnetic Prandtl numbers, Pr m > 1. For large Pr m , field line stochasticity is suppressed at very small scales, impeding diffusion. In addition, viscosity suppresses very small-scale differential motions and therefore also the local reconnection. Here we consider the effect of high magnetic Prandtl numbers on the global reconnection rate in a turbulent medium and provide a diffusion equation for the magnetic field lines considering both resistive and viscous dissipation. We find that the width of the outflow region is unaffected unless Pr m is exponentially larger than the Reynolds number Re. The ejection velocity of matter from the reconnection region is also unaffected by viscosity unless Re ∼ 1. By these criteria the reconnection rate in typical astrophysical systems is almost independent of viscosity. This remains true for reconnection in quiet environments where current sheet instabilities drive reconnection. However, if Pr m > 1, viscosity can suppress small-scale reconnection events near and below the Kolmogorov or viscous damping scale. This will produce a threshold for the suppression of large-scale reconnection by viscosity when {\\Pr }m> \\sqrt{Re}}. In any case, for Pr m > 1 this leads to a flattening of the magnetic fluctuation power spectrum, so that its spectral index is ∼‑4/3 for length scales between the viscous dissipation scale and eddies larger by roughly {{\\Pr }}m3/2. Current numerical simulations are insensitive to this effect. We suggest that the dependence of reconnection on viscosity in these simulations may be due to insufficient resolution for the turbulent inertial range rather than a guide to the large Re limit.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Rees, D.C.; Wood, R.W.; Laties, V.G.
1984-03-01
The behavioral effects of d-amphetamine have been shown to be modulated by stimulus control, with less impairment of performance occurring when control is great. When the fixed-consecutive-number schedule is used (on which at least a specified consecutive number of responses must be made on one operandum before a single response on another will produce a reinforcer), response rate tends to invariant but reinforcement frequency is not. This study asks whether the differences in reinforcement frequency that usually accompany changes in stimulus control could themselves be responsible for the performance differences. Two versions of the fixed-consecutive-number schedule of reinforcement were combinedmore » into a multiple schedule within which stimulus control was varied but differences in reinforcement frequency were minimized by omitting some reinforcer deliveries during the component that usually had the higher reinforcement frequency. In one component, a compound discriminative stimulus was added with the eighth consecutive response on the first lever, a single response on the second lever was then reinforced. In the other component, no such stimulus was presented. With no added stimulus, large decreases occurred in the number of runs satisfying the minimum requirement for reinforcement at doses of drug that produced only minimal changes when an added stimulus controlled behavior. Thus, increased stimulus control diminishes the behavioral changes produced by d-amphetamine even when the possible contribution by baseline reinforcement rate is minimized. 17 references, 6 figures, 4 tables.« less
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van Iersel, Leo; Kelk, Steven; Lekić, Nela; Scornavacca, Celine
2014-05-05
Reticulate events play an important role in determining evolutionary relationships. The problem of computing the minimum number of such events to explain discordance between two phylogenetic trees is a hard computational problem. Even for binary trees, exact solvers struggle to solve instances with reticulation number larger than 40-50. Here we present CycleKiller and NonbinaryCycleKiller, the first methods to produce solutions verifiably close to optimality for instances with hundreds or even thousands of reticulations. Using simulations, we demonstrate that these algorithms run quickly for large and difficult instances, producing solutions that are very close to optimality. As a spin-off from our simulations we also present TerminusEst, which is the fastest exact method currently available that can handle nonbinary trees: this is used to measure the accuracy of the NonbinaryCycleKiller algorithm. All three methods are based on extensions of previous theoretical work (SIDMA 26(4):1635-1656, TCBB 10(1):18-25, SIDMA 28(1):49-66) and are publicly available. We also apply our methods to real data.
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Hydration benefits to courtship feeding in crickets
Ivy, T. M.; Johnson, J. C.; Sakaluk, S. K.
1999-01-01
The spermatophore transferred by male decorated crickets (Gryllodes sigillatus) at mating includes a large gelatinous spermatophylax that the female consumes after copulation. Although previous studies have shown that G. sigillatus females gain no nutritional benefits from consuming food gifts, there may be other benefits to their consumption. We examined potential hydration benefits to females by experimentally manipulating both the availability of water and the number of food gifts that females consumed, and by measuring their effect on female fitness. Analysis of the number of nymphs produced by females revealed a significant interaction between the number of spermatophylaxes consumed and water availability. When spermatophylaxes were not provided, females given water ad libitum produced significantly more nymphs than females subjected to water stress. Female longevity was significantly affected by water availability, with an increase in the availability of water corresponding to a significant increase in female longevity. These data suggest that female G. sigillatus accrue fitness benefits by consuming spermatophylaxes when alternative sources of water are unavailable. In addition, females appear to allocate water contained in spermatophylaxes towards reproduction as opposed to survival.
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NASA Astrophysics Data System (ADS)
Pekker, David; Clark, Bryan K.; Oganesyan, Vadim; Refael, Gil; Tian, Binbin
Many-body localization is a dynamical phase of matter that is characterized by the absence of thermalization. One of the key characteristics of many-body localized systems is the emergence of a large (possibly maximal) number of local integrals of motion (local quantum numbers) and corresponding conserved quantities. We formulate a robust algorithm for identifying these conserved quantities, based on Wegner's flow equations - a form of the renormalization group that works by disentangling the degrees of freedom of the system as opposed to integrating them out. We test our algorithm by explicit numerical comparison with more engineering based algorithms - Jacobi rotations and bi-partite matching. We find that the Wegner flow algorithm indeed produces the more local conserved quantities and is therefore more optimal. A preliminary analysis of the conserved quantities produced by the Wegner flow algorithm reveals the existence of at least two different localization lengthscales. Work was supported by AFOSR FA9550-10-1-0524 and FA9550-12-1-0057, the Kaufmann foundation, and SciDAC FG02-12ER46875.
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Hicar, Mark D; Chen, Xuemin; Kalams, Spyros A; Sojar, Hakimuddin; Landucci, Gary; Forthal, Donald N; Spearman, Paul; Crowe, James E
2016-02-01
Neutralizing antibodies (Abs) are thought to be a critical component of an appropriate HIV vaccine response. It has been proposed that Abs recognizing conformationally dependent quaternary epitopes on the HIV envelope (Env) trimer may be necessary to neutralize diverse HIV strains. A number of recently described broadly neutralizing monoclonal Abs (mAbs) recognize complex and quaternary epitopes. Generally, many such Abs exhibit extensive numbers of somatic mutations and unique structural characteristics. We sought to characterize the native antibody (Ab) response against circulating HIV focusing on such conformational responses, without a prior selection based on neutralization. Using a capture system based on VLPs incorporating cleaved envelope protein, we identified a selection of B cells that produce quaternary epitope targeting Abs (QtAbs). Similar to a number of broadly neutralizing Abs, the Ab genes encoding these QtAbs showed extensive numbers of somatic mutations. However, when expressed as recombinant molecules, these Abs failed to neutralize virus or mediate ADCVI activity. Molecular analysis showed unusually high numbers of mutations in the Ab heavy chain framework 3 region of the variable genes. The analysis suggests that large numbers of somatic mutations occur in Ab genes encoding HIV Abs in chronically infected individuals in a non-directed, stochastic, manner. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Earth-based remote sensing of planetary surfaces and atmospheres at radio wavelengths
NASA Technical Reports Server (NTRS)
Dickel, J. R.
1982-01-01
Two reasons for remote sensing from the Earth are given: (1) space exploration, particularly below the surfaces or underneath cloud layers, is limited to only a very few planets; and (2) a program of regular monitoring, currently impractical with a limited number of space probes, is required. Reflected solar and nonthermal radiation are discussed. Relativistic electrons, trapped in large magnetospheres on Saturn and Jupiter, are discussed. These electrons produce synchrotron radiation and also interact with the ionosphere to produce bursts of low frequency emission. Because most objects are black-bodies, continuum radiometry is emphasized. Spectroscopic techniques and the measurement of nonthermal emission are also discussed.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Wilcox, E.
2014-09-01
LanzaTech and NREL will investigate the integration between biomass gasification and LanzaTech's proprietary gas fermentation process to produce ethanol and 2,3-butanediol. Using three feed materials (woody biomass, agricultural residue and herbaceous grass) NREL will produce syngas via steam indirect gasification and syngas conditioning over a range of process relevant operating conditions. The gasification temperature, steam-to-biomass ratio of the biomass feed into the gasifier, and several levels of syngas conditioning (based on temperature) will be varied to produce multiple syngas streams that will be fed directly to 10 liter seed fermenters operating with the Lanzatech organism. The NREL gasification system willmore » then be integrated with LanzaTech's laboratory pilot unit to produce large-scale samples of ethanol and 2,3-butanediol for conversion to fuels and chemicals.« less
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Technical and economic assessment of processes for the production of butanol and acetone
NASA Technical Reports Server (NTRS)
1982-01-01
This report represents a preliminary technical and economic evaluation of a process which produces mixed solvents (butaol/acetone/ethanol) via fermentation of sugars derived from renewable biomass resources. The objective is to assess the technology of producing butanol/acetone from biomass, and select a viable process capable of serving as a base case model for technical and economic analysis. It is anticipated that the base case process developed herein can then be used as the basis for subsequent studies concerning biomass conversion processes capable of producing a wide range of chemicals. The general criteria utilized in determining the design basis for the process are profit potential and non-renewable energy displacement potential. The feedstock chosen, aspen wood, was selected from a number of potential renewable biomass resources as the most readily available in the United States and for its relatively large potential for producing reducing sugars.
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Genetic analysis of rice mutants responsible for narrow leaf phenotype and reduced vein number.
Kubo, Fumika Clara; Yasui, Yukiko; Kumamaru, Toshihiro; Sato, Yutaka; Hirano, Hiro-Yuki
2017-03-17
Leaves are a major site for photosynthesis and a key determinant of plant architecture. Rice produces thin and slender leaves, which consist of the leaf blade and leaf sheath separated by the lamina joint. Two types of vasculature, the large and small vascular bundles, run in parallel, together with a strong structure, the midrib. In this paper, we examined the function of four genes that regulate the width of the leaf blade and the vein number: NARROW LEAF1 (NAL1), NAL2, NAL3 and NAL7. We backcrossed original mutants of these genes with the standard wild-type rice, Taichung 65. We then compared the effect of each mutation on similar genetic backgrounds and examined genetic interactions of these genes. The nal1 single mutation and the nal2 nal3 double mutation showed a severe effect on leaf width, resulting in very narrow leaves. Although vein number was also reduced in the nal1 and nal2 nal3 mutants, the small vein number was more strongly reduced than the large vein number. In contrast, the nal7 mutation showed a milder effect on leaf width and vein number, and both the large and small veins were similarly affected. Thus, the genes responsible for narrow leaf phenotype seem to play distinct roles. The nal7 mutation showed additive effects on both leaf width and vein number, when combined with the nal1 single or the nal2 nal3 double mutation. In addition, observations of inner tissues revealed that cell differentiation was partially compromised in the nal2 nal3 nal7 mutant, consistent with the severe reduction in leaf width in this triple mutant.
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Floating basaltic lava balloons - constrains on the eruptive process based on morphologic parameters
NASA Astrophysics Data System (ADS)
Pacheco, J. M.; Zanon, V.; Kueppers, U.
2011-12-01
The 1998-2001 submarine Serreta eruption brought to science a new challenge. This eruption took place offshore of Terceira Island (Azores), on the so-called Serreta Submarine Ridge, corresponding to a basaltic fissure zone with alkaline volcanism, within a tectonic setting controlled by an hyper-slow spreading rift (the Terceira Rift). The inferred eruptive centers are alignment along a NE-SW direction over an area with depths ranging from 300 to more than 1000 meters. The most remarkable products of this eruption, were large basaltic balloons observed floating at the sea surface. Those balloons, designated as Lava Balloons, are spherical to ellipsoidal structures, ranging from 0.4 up to about 3 m in length, consisting of a thin lava shell enveloping a closed hollow interior, normally formed by a single large vesicle, or a few large convoluted vesicles, that grants an overall density below water density. The cross section of the lava shell usually ranges between 3 and 8 cm and has a distinct layered structure, with different layers defined by different vesicularity, bubble number density and crystal content. The outermost layer is characterized by very small vesicles and high bubble number density whereas the innermost layer has larger vesicles, lower bubble number density and higher crystal content. These observations indicate that the rapidly quenched outer layer preserved the original small vesicles present on the magma at the time of the balloon's formation while the inner layer continued to evolve, producing higher crystal content and allowing time for the expansion of vesicles inward and their efficient coalescence. The outer surface of the balloons exhibits patches of very smooth glassy surface and areas with striation and grooves resulting from small scale fluidal deformation. These surface textures are interpreted as the result of the extrusion process and were produced in a similar manner to the striation found on subaerial toothpaste lavas. Such characteristics are indicative that the outer surface of the balloon quenched as it was being extruded and preserved the scars of a squeeze-up process. On this outer surface, several superficial expansion cracks reveal that after its generation the balloon endured some expansion before reaching the sea surface, most likely due to hydrostatic decompression during its rise. The entire shell of the balloons shows bends and folds resulting from large ductile deformations, also suggesting an origin as an effusive process of squeezing-up a large vesicle through a fissure in a thin lava crust, similarly to the extrusion of a gas filled lava toe. Actually, the volume of the lava shell is not enough to produce all the gas in the balloons interior. More likely, at an earlier stage, degassing of magma as an open system allowed gas to segregate and accumulate to form large vesicles. The development of very large vesicles would be favored by a ponding system such as a lava lake.
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Development of Advanced Materials for Electro-Ceramic Application Final Report CRADA No. TC-1331-96
DOE Office of Scientific and Technical Information (OSTI.GOV)
Caplan, M.; Olstad, R.; McMillan, L.
The goal of this project was to further develop and characterize the electrochemical methods originating in Russia for producing ultra high purity organometallic compounds utilized as precursors in the production of high quality electro-ceramic materials. Symetrix planned to use electro-ceramic materials with high dielectric constant for microelectronic memory circuit applications. General Atomics planned to use the barium titanate type ceramics with low loss tangent for producing a high power ferroelectric tuner used to match radio frequency power into their Dill-D fusion machine. Phase I of the project was scheduled to have a large number of organometallic (alkoxides) chemical samples producedmore » using various methods. These would be analyzed by LLNL, Soliton and Symetrix independently to determine the level of chemical impurities thus verifying each other's analysis. The goal was to demonstrate a cost-effective production method, which could be implemented in a large commercial facility to produce high purity organometallic compounds. In addition, various compositions of barium-strontium-titanate ceramics were to be produced and analyzed in order to develop an electroceramic capacitor material having the desired characteristics with respect to dielectric constant, loss tangent, temperature characteristics and non-linear behavior under applied voltage. Upon optimizing the barium titanate material, 50 capacitor preforms would be produced from this material demonstrating the ability to produce, in quantity, the pills ultimately required for the ferroelectric tuner (approx 2000-3000 ceramic pills).« less
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Tyree, M T; Dixon, M A; Tyree, E L; Johnson, R
1984-08-01
Measurements are reported of ultrasonic acoustic emissions (AEs) measured from sapwood samples of Thuja occidentalis L. and Tsuga canadensis (L.) Carr. during air dehydration. The measurements were undertaken to test the following three hypotheses: (a) Each cavitation event produces one ultrasonic AE. (b) Large tracheids are more likely to cavitate than small tracheids. (c) When stem water potentials are >-0.4 MPa, a significant fraction of the water content of sapwood is held by ;capillary forces.' The last two hypotheses were recently discussed at length by M. H. Zimmermann. Experimental evidence consistent with all three hypotheses was obtained. The evidence for each hypothesis respectively is: (a) the cumulative number of AEs nearly equals the number of tracheids in small samples; (b) more water is lost per AE event at the beginning of the dehydration process than at the end, and (c) sapwood samples dehydrated from an initial water potential of 0 MPa lost significantly more water before AEs started than lost by samples dehydrated from an initial water potential of about -0.4 MPa. The extra water held by fully hydrated sapwood samples may have been capillary water as defined by Zimmerman.We also report an improved method for the measurement of the ;intensity' of ultrasonic AEs. Intensity is defined here as the area under the positive spikes of the AE signal (plotted as voltage versus time). This method was applied to produce a frequency histogram of the number of AEs versus intensity. A large fraction of the total number of AEs were of low intensity even in small samples (4 mm diameter by 10 mm length). This suggests that the effective ;listening distance' for most AEs was less than 5 to 10 mm.
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Ultrasonic Acoustic Emissions from the Sapwood of Cedar and Hemlock 1
Tyree, Melvin T.; Dixon, Michael A.; Tyree, E. Loeta; Johnson, Robert
1984-01-01
Measurements are reported of ultrasonic acoustic emissions (AEs) measured from sapwood samples of Thuja occidentalis L. and Tsuga canadensis (L.) Carr. during air dehydration. The measurements were undertaken to test the following three hypotheses: (a) Each cavitation event produces one ultrasonic AE. (b) Large tracheids are more likely to cavitate than small tracheids. (c) When stem water potentials are >−0.4 MPa, a significant fraction of the water content of sapwood is held by `capillary forces.' The last two hypotheses were recently discussed at length by M. H. Zimmermann. Experimental evidence consistent with all three hypotheses was obtained. The evidence for each hypothesis respectively is: (a) the cumulative number of AEs nearly equals the number of tracheids in small samples; (b) more water is lost per AE event at the beginning of the dehydration process than at the end, and (c) sapwood samples dehydrated from an initial water potential of 0 MPa lost significantly more water before AEs started than lost by samples dehydrated from an initial water potential of about −0.4 MPa. The extra water held by fully hydrated sapwood samples may have been capillary water as defined by Zimmerman. We also report an improved method for the measurement of the `intensity' of ultrasonic AEs. Intensity is defined here as the area under the positive spikes of the AE signal (plotted as voltage versus time). This method was applied to produce a frequency histogram of the number of AEs versus intensity. A large fraction of the total number of AEs were of low intensity even in small samples (4 mm diameter by 10 mm length). This suggests that the effective `listening distance' for most AEs was less than 5 to 10 mm. PMID:16663774
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Optimizing an F-16 Squadron Weekly Pilot Schedule for the Turkish Air Force
2010-03-01
disrupted schedules are rescheduled , minimizing the total number of changes with respect to the previous schedule’s objective function. Output...producing rosters for a nursing staff in a large general hospital (Dowsland, 1998) and afterwards Aickelin and Dowsland use an Indirect Genetic...algorithm to improve the solutions of the nurse scheduling problem which is similar to the fighter squadron pilot scheduling problem (Aickelin and
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1991-12-02
number of protein or sugar agents were experimented with including Agar, pectin, carboxymethylcellulose, gelatin, alginic acid, xanthan gum , guar gum ...I) Introduction and Description of Scientific Goals 1 II) Material and Powder Synthesis 1 A) Freeze Dried Fabrication of Powders 1 B) Utilization of...composites. II). Material and Powder Synthesis The availability of a reliable technique for producing large quantities of phase pure, submicron powders
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ERIC Educational Resources Information Center
Grünke, Matthias; Wilbert, Jürgen; Tsiriotakis, Ioanna K.; Agirregoikoa, Ainhize Lopez
2017-01-01
A large number of students struggle with composition writing. This is alarming since problems in this area reduce the chances of succeeding in school and life in general. Children and youth with learning disabilities (LD) are especially at risk of not acquiring the skills necessary to produce texts of an acceptable length and quality.…
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Electrostatic camera system functional design study
NASA Technical Reports Server (NTRS)
Botticelli, R. A.; Cook, F. J.; Moore, R. F.
1972-01-01
A functional design study for an electrostatic camera system for application to planetary missions is presented. The electrostatic camera can produce and store a large number of pictures and provide for transmission of the stored information at arbitrary times after exposure. Preliminary configuration drawings and circuit diagrams for the system are illustrated. The camera system's size, weight, power consumption, and performance are characterized. Tradeoffs between system weight, power, and storage capacity are identified.
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A Short Study of Large Rotary Forged Cylinders
1979-06-01
ESR Steel Hollow ESR Steel Rotary Forge Vacuum Degassed Steel 20. ABSTRACT (Continue on reverse aide It necessary and identity by block number...treatment rging Line was used to produce steel for the Advanced ocram. Cylinders were rotary forged from cast hollow ESR ssed steel . Anomalies in the data...prompted a more detailed The results are presented. Satisfactory properties were cuum degassed steel . However, the very light forging th the very
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European Science Notes. Volume 41, Number 10,
1987-10-01
the following topics: laminar/turbulent transition in boundary layers; coherent structures in the modeling of turbulent boundary layers, wakes, and jets...of the labeling of a model protein, human immu- indicator. The amount of oxygen produced noglobulin (hIgG), with acridinium ester, can easily be...has concerned cations, and Computer Science. Research model reduction of large-scale systems in the controls area is conducted in the and state and
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A method of hidden Markov model optimization for use with geophysical data sets
NASA Technical Reports Server (NTRS)
Granat, R. A.
2003-01-01
Geophysics research has been faced with a growing need for automated techniques with which to process large quantities of data. A successful tool must meet a number of requirements: it should be consistent, require minimal parameter tuning, and produce scientifically meaningful results in reasonable time. We introduce a hidden Markov model (HMM)-based method for analysis of geophysical data sets that attempts to address these issues.
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Nucleation of Crystals From Solution in Microgravity (USML-1 Glovebox (GBX) Investigation)
NASA Technical Reports Server (NTRS)
Kroes, Roger L.; Reiss, Donald A.; Lehoczky, Sandor L.
1994-01-01
A new method for initiating nucleation from solutions in microgravity which avoids nucleation on container walls and other surfaces is described. This method consists of injecting a small quantity of highly concentrated, heated solution into the interior of a lightly supersaturated, cooler host gowth solution. It was tested successfully on USML-I, producing a large number of LAP crystals whose longest dimension averaged 1 mm.
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HOW THE MILITARY CAN INTEGRATE UNMANNED AERIAL SYSTEMS IN THE CIVIL RESERVE AIR FLEET
2016-10-01
brings new capabilities and continues to fundamentally impact military doctrine and strategy, particularly in how civilian operators or contractors ...missions has stretched military personnel and resources thin. General Atomics, a California-based defense contractor , produces the highly successful MQ-1...and a large number of support personnel required to operate UAS missions. An already established civilian contractor presence AU/ACSC/2016 5
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Schwemin, A.J.
1959-03-17
A generator is presented for producing relatively large currents at high voltages. In general, the invention comprises a plurality of capacitors connected in series by a plurality of switches alternately disposed with the capacitors. The circuit is mounted for movement with respect to contact members and switch closure means so that a load device and power supply are connected across successive numbers of capacitors, while the other capacitors are successively charged with the same power supply.
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Murphy, S.; Scala, A.; Herrero, A.; Lorito, S.; Festa, G.; Trasatti, E.; Tonini, R.; Romano, F.; Molinari, I.; Nielsen, S.
2016-01-01
The 2011 Tohoku earthquake produced an unexpected large amount of shallow slip greatly contributing to the ensuing tsunami. How frequent are such events? How can they be efficiently modelled for tsunami hazard? Stochastic slip models, which can be computed rapidly, are used to explore the natural slip variability; however, they generally do not deal specifically with shallow slip features. We study the systematic depth-dependence of slip along a thrust fault with a number of 2D dynamic simulations using stochastic shear stress distributions and a geometry based on the cross section of the Tohoku fault. We obtain a probability density for the slip distribution, which varies both with depth, earthquake size and whether the rupture breaks the surface. We propose a method to modify stochastic slip distributions according to this dynamically-derived probability distribution. This method may be efficiently applied to produce large numbers of heterogeneous slip distributions for probabilistic tsunami hazard analysis. Using numerous M9 earthquake scenarios, we demonstrate that incorporating the dynamically-derived probability distribution does enhance the conditional probability of exceedance of maximum estimated tsunami wave heights along the Japanese coast. This technique for integrating dynamic features in stochastic models can be extended to any subduction zone and faulting style. PMID:27725733
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2011-01-01
Background Singular value decomposition (SVD) is a powerful technique for information retrieval; it helps uncover relationships between elements that are not prima facie related. SVD was initially developed to reduce the time needed for information retrieval and analysis of very large data sets in the complex internet environment. Since information retrieval from large-scale genome and proteome data sets has a similar level of complexity, SVD-based methods could also facilitate data analysis in this research area. Results We found that SVD applied to amino acid sequences demonstrates relationships and provides a basis for producing clusters and cladograms, demonstrating evolutionary relatedness of species that correlates well with Linnaean taxonomy. The choice of a reasonable number of singular values is crucial for SVD-based studies. We found that fewer singular values are needed to produce biologically significant clusters when SVD is employed. Subsequently, we developed a method to determine the lowest number of singular values and fewest clusters needed to guarantee biological significance; this system was developed and validated by comparison with Linnaean taxonomic classification. Conclusions By using SVD, we can reduce uncertainty concerning the appropriate rank value necessary to perform accurate information retrieval analyses. In tests, clusters that we developed with SVD perfectly matched what was expected based on Linnaean taxonomy. PMID:22369633
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Computer simulation of vasectomy for wolf control
Haight, R.G.; Mech, L.D.
1997-01-01
Recovering gray wolf (Canis lupus) populations in the Lake Superior region of the United States are prompting state management agencies to consider strategies to control population growth. In addition to wolf removal, vasectomy has been proposed. To predict the population effects of different sterilization and removal strategies, we developed a simulation model of wolf dynamics using simple rules for demography and dispersal. Simulations suggested that the effects of vasectomy and removal in a disjunct population depend largely on the degree of annual immigration. With low immigration, periodic sterilization reduced pup production and resulted in lower rates of territory recolonization. Consequently, average pack size, number of packs, and population size were significantly less than those for an untreated population. Periodically removing a proportion of the population produced roughly the same trends as did sterilization; however, more than twice as many wolves had to be removed than sterilized. With high immigration, periodic sterilization reduced pup production but not territory recolonization and produced only moderate reductions in population size relative to an untreated population. Similar reductions in population size were obtained by periodically removing large numbers of wolves. Our analysis does not address the possible effects of vasectomy on larger wolf populations, but it suggests that the subject should be considered through modeling or field testing.
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Simulations of the Formation and Evolution of X-ray Clusters
NASA Astrophysics Data System (ADS)
Bryan, G. L.; Klypin, A.; Norman, M. L.
1994-05-01
We describe results from a set of Omega = 1 Cold plus Hot Dark Matter (CHDM) and Cold Dark Matter (CDM) simulations. We examine the formation and evolution of X-ray clusters in a cosmological setting with sufficient numbers to perform statistical analysis. We find that CDM, normalized to COBE, seems to produce too many large clusters, both in terms of the luminosity (dn/dL) and temperature (dn/dT) functions. The CHDM simulation produces fewer clusters and the temperature distribution (our numerically most secure result) matches observations where they overlap. The computed cluster luminosity function drops below observations, but we are almost surely underestimating the X-ray luminosity. Because of the lower fluctuations in CHDM, there are only a small number of bright clusters in our simulation volume; however we can use the simulated clusters to fix the relation between temperature and velocity dispersion, allowing us to use collisionless N-body codes to probe larger length scales with correspondingly brighter clusters. The hydrodynamic simulations have been performed with a hybrid particle-mesh scheme for the dark matter and a high resolution grid-based piecewise parabolic method for the adiabatic gas dynamics. This combination has been implemented for massively parallel computers, allowing us to achive grids as large as 512(3) .
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Lee, Ching-Pei; Lin, Chih-Jen
2014-04-01
Linear rankSVM is one of the widely used methods for learning to rank. Although its performance may be inferior to nonlinear methods such as kernel rankSVM and gradient boosting decision trees, linear rankSVM is useful to quickly produce a baseline model. Furthermore, following its recent development for classification, linear rankSVM may give competitive performance for large and sparse data. A great deal of works have studied linear rankSVM. The focus is on the computational efficiency when the number of preference pairs is large. In this letter, we systematically study existing works, discuss their advantages and disadvantages, and propose an efficient algorithm. We discuss different implementation issues and extensions with detailed experiments. Finally, we develop a robust linear rankSVM tool for public use.
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A Comparative Analysis of Extract, Transformation and Loading (ETL) Process
NASA Astrophysics Data System (ADS)
Runtuwene, J. P. A.; Tangkawarow, I. R. H. T.; Manoppo, C. T. M.; Salaki, R. J.
2018-02-01
The current growth of data and information occurs rapidly in varying amount and media. These types of development will eventually produce large number of data better known as the Big Data. Business Intelligence (BI) utilizes large number of data and information for analysis so that one can obtain important information. This type of information can be used to support decision-making process. In practice a process integrating existing data and information into data warehouse is needed. This data integration process is known as Extract, Transformation and Loading (ETL). In practice, many applications have been developed to carry out the ETL process, but selection which applications are more time, cost and power effective and efficient may become a challenge. Therefore, the objective of the study was to provide comparative analysis through comparison between the ETL process using Microsoft SQL Server Integration Service (SSIS) and one using Pentaho Data Integration (PDI).
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Classifications for carcinogenesis of antitumoral drugs.
Binetti, R; Costamagna, F M; Marcello, I
2003-12-01
The aim of this review is to support the medical staff engaged in tumor therapy with the carcinogenicity, mutagenicity, developmental toxicity classification of a large number of chemiotherapic drugs by national and international Agencies; it also gives their rationale and the few cases for which the classification varies among, for example, the European Union and the United States of America. A large list of such drugs, producers, commercial names, CAS numbers and chemical names is reported. This list is subject to changes for the quick development in this field: many drugs are retired and many more are introduced in clinical practice. The list is updated to the summer 2003 and retains many drugs which have more than one use or have limited use. The protection of the medical personnel using antitumor chemiotherapics can need retrospective epidemiological investigations and obsolete drugs are of importance for some of the past exposures.
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Presaddle and postsaddle dissipative effects in fission using complete kinematics measurements
NASA Astrophysics Data System (ADS)
Rodríguez-Sánchez, J. L.; Benlliure, J.; Taïeb, J.; Alvarez-Pol, H.; Audouin, L.; Ayyad, Y.; Bélier, G.; Boutoux, G.; Casarejos, E.; Chatillon, A.; Cortina-Gil, D.; Gorbinet, T.; Heinz, A.; Kelić-Heil, A.; Laurent, B.; Martin, J.-F.; Paradela, C.; Pellereau, E.; Pietras, B.; Ramos, D.; Rodríguez-Tajes, C.; Rossi, D. M.; Simon, H.; Vargas, J.; Voss, B.
2016-12-01
A complete kinematics measurement of the two fission fragments was used for the first time to investigate fission dynamics at small and large deformations. Fissioning systems with high excitation energies, compact shapes, and low angular momenta were produced in inverse kinematics by using spallation reactions of lead projectiles. A new generation experimental setup allowed for the first full and unambiguous identification in mass and atomic number of both fission fragments. This measurement permitted us to accurately determine fission cross sections, the charge distribution, and the neutron excess of the fission fragments as a function of the atomic number of the fissioning system. These data are compared with different model calculations to extract information on the value of the dissipation parameter at small and large deformations. The present results do not show any sizable dependence of the nuclear dissipation parameter on temperature or deformation.
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Harper, J G; Fuller, R; Sweeney, D; Waldmann, T
1998-04-01
This paper describes ergonomic issues raised during a project to provide a replacement real-time bus route control system to a large public transport company. Task and system analyses highlighted several deficiencies in the original system architecture, the human-machine interfaces and the general approach to system management. The eventual live prototype replaced the existing original system for a trial evaluation period of several weeks. During this period a number of studies was conducted with the system users in order to measure any improvements the new system, with its ergonomic features, produced over the old. Importantly, the results confirmed that (a) general responsiveness and service quality were improved, and (b) users were more comfortable with the new design. We conclude with a number of caveats which we believe will be useful to any group addressing technology impact in a large organisation.
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Towards Petascale DNS of High Reynolds-Number Turbulent Boundary Layer
NASA Astrophysics Data System (ADS)
Webster, Keegan R.
In flight vehicles, a large portion of fuel consumption is due to skin-friction drag. Reduction of this drag will significantly reduce the fuel consumption of flight vehicles and help our nation to reduce CO 2 emissions. In order to reduce skin-friction drag, an increased understanding of wall-turbulence is needed. Direct numerical simulation (DNS) of spatially developing turbulent boundary layers (SDTBL) can provide the fundamental understanding of wall-turbulence in order to produce models for Reynolds averaged Navier-Stokes (RANS) and large-eddy simulations (LES). DNS of SDTBL over a flat plate at Retheta = 1430 - 2900 were performed. Improvements were made to the DNS code allowing for higher Reynolds number simulations towards petascale DNS of turbulent boundary layers. Mesh refinement and improvements to the inflow and outflow boundary conditions have resulted in turbulence statistics that match more closely to experimental results. The Reynolds stresses and the terms of their evolution equations are reported.
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Simple chained guide trees give high-quality protein multiple sequence alignments
Boyce, Kieran; Sievers, Fabian; Higgins, Desmond G.
2014-01-01
Guide trees are used to decide the order of sequence alignment in the progressive multiple sequence alignment heuristic. These guide trees are often the limiting factor in making large alignments, and considerable effort has been expended over the years in making these quickly or accurately. In this article we show that, at least for protein families with large numbers of sequences that can be benchmarked with known structures, simple chained guide trees give the most accurate alignments. These also happen to be the fastest and simplest guide trees to construct, computationally. Such guide trees have a striking effect on the accuracy of alignments produced by some of the most widely used alignment packages. There is a marked increase in accuracy and a marked decrease in computational time, once the number of sequences goes much above a few hundred. This is true, even if the order of sequences in the guide tree is random. PMID:25002495
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Rose, P.; Powers, W.; Hritzay, D.
1959-06-01
The development of an arc wind tunnel capable of stagnation pressures in the excess of twenty atmospheres and using as much as fifteen megawatts of electrical power is described. The calibration of this facility shows that it is capable of reproducing the aerodynamic environment encountered by vehicles flying at velocities as great as satellite velocity. Its use as a missile re-entry material test facility is described. The large power capacity of this facility allows one to make material tests on specimens of size sufficient to be useful for material development yet at realistic energy and Reynolds number values. By themore » addition of a high-capacity vacuum system, this facility can be used to produce the low density, high Mach number environment needed for simulating satellite re-entry, as well as hypersonic flight at extreme altitudes. (auth)« less
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Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules.
Verboogen, Daniëlle R J; Ter Beest, Martin; Honigmann, Alf; van den Bogaart, Geert
2018-05-01
Immune cells communicate by releasing large quantities of cytokines. Although the mechanisms of cytokine secretion are increasingly understood, quantitative knowledge of the number of cytokines per vesicle is still lacking. Here, we measured with quantitative microscopy the release rate of vesicles potentially carrying interleukin-6 (IL-6) in human dendritic cells. By comparing this to the total secreted IL-6, we estimate that secretory vesicles contain about 0.5-3 IL-6 molecules, but with a large spread among cells/donors. Moreover, IL-6 did not accumulate within most cells, indicating that synthesis and not trafficking is the bottleneck for IL-6 production. IL-6 accumulated in the Golgi apparatus only in ~ 10% of the cells. Understanding how immune cells produce cytokines is important for designing new immunomodulatory drugs. © 2018 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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Zahran, Wafaa A; Ghonaim, Mabrouk M; Koura, Bothina A; El-Banna, Hassan; Ali, Sahar M; El-Sheikh, Nabila
2006-01-01
Pulmonary tuberculosis remains a major health problem. It is caused by Mycobacterium tuberculosis, which elicits a T-cell dependent immune response, initiated by monocytes through a large number of cytokines of which interleukin-12 is thought to play a critical role in initiation and regulation of T-helper (Th-1) like responses. To better understand the role of IL-12 in pulmonary tuberculosis patients, intracellular IL-12 in peripheral blood-derived monocytes was examined by flowcytometery. The percentage of monocytes producing IL-12 was measured after invitro stimulation of heparinized whole blood with mycobacterial protein antigens (culture filtrate). Of the 22 active tuberculosis patients, 17 were recent cases and 5 recurrent cases. Healthy controls were 14 individuals with detectable reaction to purified protein derivative (PPD+) and 14 without detectable reaction to PPD. The role of different factors affecting disease outcome such as treatment, age, gender, smoking, severity of disease and presence of other complications on the percentage of monocytes producing IL-12 was studied. Recurrent TB patients had a higher number of monocytes producing IL-12 in unstimulated cultures compared to other groups (P < 0.001). However, after in vitro stimulation there was a significant decrease in the number of monocytes producing IL-12 in recurrent TB patients as compared to recently diagnosed TB patients and healthy PPD+ individuals (P < 0.001). Antituberculosis chemotherapy was the only factor that had significant effect on the percentage of monocytes producing IL-12 (p < 0.05) while other studied factors did not show significant effect (p > 0.05). It is concluded that IL-12 plays a prominent regulatory role in tuberculosis.
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Preservation and fermentation: past, present and future.
Ross, R Paul; Morgan, S; Hill, C
2002-11-15
Preservation of food and beverages resulting from fermentation has been an effective form of extending the shelf-life of foods for millennia. Traditionally, foods were preserved through naturally occurring fermentations, however, modern large scale production generally now exploits the use of defined strain starter systems to ensure consistency and quality in the final product. This review will mainly focus on the use of lactic acid bacteria (LAB) for food improvement, given their extensive application in a wide range of fermented foods. These microorganisms can produce a wide variety of antagonistic primary and secondary metabolites including organic acids, diacetyl, CO2 and even antibiotics such as reuterocyclin produced by Lactobacillus reuteri. In addition, members of the group can also produce a wide range of bacteriocins, some of which have activity against food pathogens such as Listeria monocytogenes and Clostridium botulinum. Indeed, the bacteriocin nisin has been used as an effective biopreservative in some dairy products for decades, while a number of more recently discovered bacteriocins, such as lacticin 3147, demonstrate increasing potential in a number of food applications. Both of these lactococcal bacteriocins belong to the lantibiotic family of posttranslationally modified bacteriocins that contain lanthionine, beta-methyllanthionine and dehydrated amino acids. The exploitation of such naturally produced antagonists holds tremendous potential for extension of shelf-life and improvement of safety of a variety of foods.
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The isolation of salmonellas from British pork sausages and sausage meat.
Roberts, D.; Boag, K.; Hall, M. L.; Shipp, C. R.
1975-01-01
Between 1969 and 1974, 1467 packets (3309 samples) of pork sausages and sausage meat produced by two large and two medium sized manufacturers and several local butchers were examined for the presence of salmonellas. Of these, 435 packets (786 samples) were found to contain salmonellas, but there was a wide variation in the isolation rates according to the producer. The salmonella incidence in samples from several small and two medium sized producers was low (0-11%) while the results from the two large producers investigated showed a striking difference, the rate of salmonella contamination in the product of one was low (about 2%) and in that of the other consistently high (40-60%). A comparison of liquid enrichment media, incubation temperatures and selective agar media was also carried out to determine the most efficient combination for the isolation of salmonellas from minced meat products. The results showed that (a) incubation of enrichment cultures at 43 degrees C. yielded a consistently greater number of salmonella isolations that at 37 degrees C., regardless of plating medium, (b) tetrathionate broth A (Rolfe) was superior to selenite broth as en enrichment medium at both 37 and 43 degrees C. and (c) brilliant green agar gave better results than deoxycholate citrate sucrose agar and bismuth sulphite agar as a selective medium. PMID:1100710
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The isolation of salmonellas from British pork sausages and sausage meat.
Roberts, D; Boag, K; Hall, M L; Shipp, C R
1975-10-01
Between 1969 and 1974, 1467 packets (3309 samples) of pork sausages and sausage meat produced by two large and two medium sized manufacturers and several local butchers were examined for the presence of salmonellas. Of these, 435 packets (786 samples) were found to contain salmonellas, but there was a wide variation in the isolation rates according to the producer. The salmonella incidence in samples from several small and two medium sized producers was low (0-11%) while the results from the two large producers investigated showed a striking difference, the rate of salmonella contamination in the product of one was low (about 2%) and in that of the other consistently high (40-60%). A comparison of liquid enrichment media, incubation temperatures and selective agar media was also carried out to determine the most efficient combination for the isolation of salmonellas from minced meat products. The results showed that (a) incubation of enrichment cultures at 43 degrees C. yielded a consistently greater number of salmonella isolations that at 37 degrees C., regardless of plating medium, (b) tetrathionate broth A (Rolfe) was superior to selenite broth as en enrichment medium at both 37 and 43 degrees C. and (c) brilliant green agar gave better results than deoxycholate citrate sucrose agar and bismuth sulphite agar as a selective medium.
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Technique Using Axicons For Generating Flat Top Laser Beam Profiles
NASA Astrophysics Data System (ADS)
Viswanathan, V. K.; Woodfin, G. L.; Stahl, D.; Carpenter, J. P.; Kyrala, G.
1983-11-01
In certain fusion experiments using CO2 lasers, like Helios, it is desired to produce a focal spot several times larger than the nominal focal spot, with a flat beam profile. The typical focal spot in Helios is roughly 70 μm and just defocussing the beam produces beam breakup, with several hot spots with roughly the original diameter, and a gaussian distribution. A number of schemes were tried to achieve a large spot with desired characteristics. These are described in the article. Axicons were found to produce spots with desired characteristics. Axicons are lenses or mirrors having a cone-shaped surface. The various schemes are described, as well as an. experiment in Helios which confirmed that axicons produced the spots with desirable characteristics. Helios is an 8-beam CO2 laser which produces 10 kJ at power in excess of 20 TW. It is currently being used for Laser Fusion studies at the Los Alamos National Laboratory.
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New pathway of stratocumulus to cumulus transition via aerosol-cloud-precipitation interaction
NASA Astrophysics Data System (ADS)
Yamaguchi, T.; Feingold, G.; Kazil, J.
2017-12-01
The stratocumulus to cumulus transition (SCT) is typically considered to be a slow, multi-day process, caused primarily by dry air entrainment associated with overshooting cumulus rising under stratocumulus, with minor influence of precipitation. In this presentation, we show rapid SCT induced by a strong precipitation-induced modulation with Lagrangian SCT large eddy simulations. A large eddy model is coupled with a two-moment bulk microphysics scheme that predicts aerosol and droplet number concentrations. Moderate aerosol concentrations (100-250 cm-3) produce little to no drizzle from the stratocumulus deck. Large amounts of rain eventually form and wash out stratocumulus and much of the aerosol, and a cumulus state appears for approximately 10 hours. Initiation of strong rain formation is identified in penetrative cumulus clouds which are much deeper than stratocumulus, and they are able to condense large amounts of water. We show that prediction of cloud droplet number is necessary for this fast SCT since it is a result of a positive feedback of collision-coalescence induced aerosol depletion enhancing drizzle formation. Simulations with fixed droplet concentrations that bracket the time varying aerosol/drop concentrations are therefore not representative of the role of drizzle in the SCT.
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Weak-signal Phase Calibration Strategies for Large DSN Arrays
NASA Technical Reports Server (NTRS)
Jones, Dayton L.
2005-01-01
The NASA Deep Space Network (DSN) is studying arrays of large numbers of small, mass-produced radio antennas as a cost-effective way to increase downlink sensitivity and data rates for future missions. An important issue for the operation of large arrays is the accuracy with which signals from hundreds of small antennas can be combined. This is particularly true at Ka band (32 GHz) where atmospheric phase variations can be large and rapidly changing. A number of algorithms exist to correct the phases of signals from individual antennas in the case where a spacecraft signal provides a useful signal-to-noise ratio (SNR) on time scales shorter than the atmospheric coherence time. However, for very weak spacecraft signals it will be necessary to rely on background natural radio sources to maintain array phasing. Very weak signals could result from a spacecraft emergency or by design, such as direct-to-Earth data transmissions from distant planetary atmospheric or surface probes using only low gain antennas. This paper considers the parameter space where external real-time phase calibration will be necessary, and what this requires in terms of array configuration and signal processing. The inherent limitations of this technique are also discussed.
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Wood, Henry M; Belvedere, Ornella; Conway, Caroline; Daly, Catherine; Chalkley, Rebecca; Bickerdike, Melissa; McKinley, Claire; Egan, Phil; Ross, Lisa; Hayward, Bruce; Morgan, Joanne; Davidson, Leslie; MacLennan, Ken; Ong, Thian K; Papagiannopoulos, Kostas; Cook, Ian; Adams, David J; Taylor, Graham R; Rabbitts, Pamela
2010-08-01
The use of next-generation sequencing technologies to produce genomic copy number data has recently been described. Most approaches, however, reply on optimal starting DNA, and are therefore unsuitable for the analysis of formalin-fixed paraffin-embedded (FFPE) samples, which largely precludes the analysis of many tumour series. We have sought to challenge the limits of this technique with regards to quality and quantity of starting material and the depth of sequencing required. We confirm that the technique can be used to interrogate DNA from cell lines, fresh frozen material and FFPE samples to assess copy number variation. We show that as little as 5 ng of DNA is needed to generate a copy number karyogram, and follow this up with data from a series of FFPE biopsies and surgical samples. We have used various levels of sample multiplexing to demonstrate the adjustable resolution of the methodology, depending on the number of samples and available resources. We also demonstrate reproducibility by use of replicate samples and comparison with microarray-based comparative genomic hybridization (aCGH) and digital PCR. This technique can be valuable in both the analysis of routine diagnostic samples and in examining large repositories of fixed archival material.
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High-energy radiation from collisions of high-velocity clouds and the Galactic disc
NASA Astrophysics Data System (ADS)
del Valle, Maria V.; Müller, A. L.; Romero, G. E.
2018-04-01
High-velocity clouds (HVCs) are interstellar clouds of atomic hydrogen that do not follow normal Galactic rotation and have velocities of a several hundred kilometres per second. A considerable number of these clouds are falling down towards the Galactic disc. HVCs form large and massive complexes, so if they collide with the disc a great amount of energy would be released into the interstellar medium. The cloud-disc interaction produces two shocks: one propagates through the cloud and the other through the disc. The properties of these shocks depend mainly on the cloud velocity and the disc-cloud density ratio. In this work, we study the conditions necessary for these shocks to accelerate particles by diffusive shock acceleration and we study the non-thermal radiation that is produced. We analyse particle acceleration in both the cloud and disc shocks. Solving a time-dependent two-dimensional transport equation for both relativistic electrons and protons, we obtain particle distributions and non-thermal spectral energy distributions. In a shocked cloud, significant synchrotron radio emission is produced along with soft gamma rays. In the case of acceleration in the shocked disc, the non-thermal radiation is stronger; the gamma rays, of leptonic origin, might be detectable with current instruments. A large number of protons are injected into the Galactic interstellar medium, and locally exceed the cosmic ray background. We conclude that under adequate conditions the contribution from HVC-disc collisions to the galactic population of relativistic particles and the associated extended non-thermal radiation might be important.
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NASA Technical Reports Server (NTRS)
Xu, Kuan-Man; Luo, Yali; Morrison, Hugh; Mcfarquhar, G.M.
2008-01-01
Single-layer mixed-phase stratiform (MPS) Arctic clouds, which formed under conditions of large surface heat flux combined with general subsidence during a subperiod of the Atmospheric Radiation Measurement (ARM) Program Mixed-Phase Arctic Cloud Experiment (M-PACE), are simulated with a cloud resolving model (CRM). The CRM is implemented with either an advanced two-moment (M05) or a commonly used one-moment (L83) bulk microphysics scheme and a state-of-the-art radiative transfer scheme. The CONTROL simulation, that uses the M05 scheme and observed aerosol size distribution and ice nulei (IN) number concentration, reproduces the magnitudes and vertical structures of cloud liquid water content (LWC), total ice water content (IWC), number concentration and effective radius of cloud droplets as suggested by the M-PACE observations. It underestimates ice crystal number concentrations by an order of magnitude and overestimates effective radius of ice crystals by a factor of 2-3. The OneM experiment, that uses the L83 scheme, produces values of liquid water path (LWP) and ice plus snow water path (ISWP) that were about 30% and 4 times, respectively, of those produced by the CONTROL. Its vertical profile of IWC exhibits a bimodal distribution in contrast to the constant distribution of IWC produced in the CONTROL and observations.
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Parametric investigation of single-expansion-ramp nozzles at Mach numbers from 0.60 to 1.20
NASA Technical Reports Server (NTRS)
Capone, Francis J.; Re, Richard J.; Bare, E. Ann
1992-01-01
An investigation was conducted in the Langley 16-Foot Transonic Tunnel to determine the effects of varying six nozzle geometric parameters on the internal and aeropropulsive performance characteristics of single-expansion-ramp nozzles. This investigation was conducted at Mach numbers from 0.60 to 1.20, nozzle pressure ratios from 1.5 to 12, and angles of attack of 0 deg +/- 6 deg. Maximum aeropropulsive performance at a particular Mach number was highly dependent on the operating nozzle pressure ratio. For example, as the nozzle upper ramp length or angle increased, some nozzles had higher performance at a Mach number of 0.90 because of the nozzle design pressure was the same as the operating pressure ratio. Thus, selection of the various nozzle geometric parameters should be based on the mission requirements of the aircraft. A combination of large upper ramp and large lower flap boattail angles produced greater nozzle drag coefficients at Mach number greater than 0.80, primarily from shock-induced separation on the lower flap of the nozzle. A static conditions, the convergent nozzle had high and nearly constant values of resultant thrust ratio over the entire range of nozzle pressure ratios tested. However, these nozzles had much lower aeropropulsive performance than the convergent-divergent nozzle at Mach number greater than 0.60.
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Structure—activity relationships for insecticidal carbamates*
Metcalf, Robert L.
1971-01-01
Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal action of AChE so that acetylcholine accumulates at synaptic junctions. The necessary properties for a suitable insecticidal carbamate are lipid solubility, suitable structural complementarity to AChE, and sufficient stability to multifunction-oxidase detoxification. The relationships between the structure and the activity of a large number of synthetic carbamates are analysed in detail, with particular attention to the second of these properties. PMID:5315358
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Three-body affairs in the outer solar system
NASA Astrophysics Data System (ADS)
Funato, Yoko; Makino, Junichiro; Hut, Piet; Kokubo, Eiichiro; Kinoshita, Daisuke
Recent observations have revealed an unexpectedly high binary fraction among the Trans-Neptunian Objects (TNOs) that populate the Kuiper Belt. The TNO binaries are strikingly different from asteroid binaries in four respects: their frequency is an order of magnitude larger, the mass ratio of their components is closer to unity, and their orbits are wider and highly eccentric. Two explanations have been proposed for their formation, one assuming large numbers of massive bodies, and one assuming large numbers of light bodies. We argue that both assumptions are unwarranted, and we show how TNO binaries can be produced from a modest number of intermediate-mass bodies of the type predicted by the gravitational instability theory for the formation of planetesimals. We start with a TNO binary population similar to the asteroid binary population, but subsequently modified by three-body exchange reactions, a process that is far more efficient in the Kuiper belt, because of the much smaller tidal perturbations by the Sun. Our mechanism can naturally account for all four characteristics that distinguish TNO binaries from main-belt asteroid binaries.
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NASA Astrophysics Data System (ADS)
Figueroa, Aldo; Meunier, Patrice; Cuevas, Sergio; Villermaux, Emmanuel; Ramos, Eduardo
2014-01-01
We present a combination of experiment, theory, and modelling on laminar mixing at large Péclet number. The flow is produced by oscillating electromagnetic forces in a thin electrolytic fluid layer, leading to oscillating dipoles, quadrupoles, octopoles, and disordered flows. The numerical simulations are based on the Diffusive Strip Method (DSM) which was recently introduced (P. Meunier and E. Villermaux, "The diffusive strip method for scalar mixing in two-dimensions," J. Fluid Mech. 662, 134-172 (2010)) to solve the advection-diffusion problem by combining Lagrangian techniques and theoretical modelling of the diffusion. Numerical simulations obtained with the DSM are in reasonable agreement with quantitative dye visualization experiments of the scalar fields. A theoretical model based on log-normal Probability Density Functions (PDFs) of stretching factors, characteristic of homogeneous turbulence in the Batchelor regime, allows to predict the PDFs of scalar in agreement with numerical and experimental results. This model also indicates that the PDFs of scalar are asymptotically close to log-normal at late stages, except for the large concentration levels which correspond to low stretching factors.
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A rice kinase-protein interaction map.
Ding, Xiaodong; Richter, Todd; Chen, Mei; Fujii, Hiroaki; Seo, Young Su; Xie, Mingtang; Zheng, Xianwu; Kanrar, Siddhartha; Stevenson, Rebecca A; Dardick, Christopher; Li, Ying; Jiang, Hao; Zhang, Yan; Yu, Fahong; Bartley, Laura E; Chern, Mawsheng; Bart, Rebecca; Chen, Xiuhua; Zhu, Lihuang; Farmerie, William G; Gribskov, Michael; Zhu, Jian-Kang; Fromm, Michael E; Ronald, Pamela C; Song, Wen-Yuan
2009-03-01
Plants uniquely contain large numbers of protein kinases, and for the vast majority of the 1,429 kinases predicted in the rice (Oryza sativa) genome, little is known of their functions. Genetic approaches often fail to produce observable phenotypes; thus, new strategies are needed to delineate kinase function. We previously developed a cost-effective high-throughput yeast two-hybrid system. Using this system, we have generated a protein interaction map of 116 representative rice kinases and 254 of their interacting proteins. Overall, the resulting interaction map supports a large number of known or predicted kinase-protein interactions from both plants and animals and reveals many new functional insights. Notably, we found a potential widespread role for E3 ubiquitin ligases in pathogen defense signaling mediated by receptor-like kinases, particularly by the kinases that may have evolved from recently expanded kinase subfamilies in rice. We anticipate that the data provided here will serve as a foundation for targeted functional studies in rice and other plants. The application of yeast two-hybrid and TAPtag analyses for large-scale plant protein interaction studies is also discussed.
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Recording large-scale neuronal ensembles with silicon probes in the anesthetized rat.
Schjetnan, Andrea Gomez Palacio; Luczak, Artur
2011-10-19
Large scale electrophysiological recordings from neuronal ensembles offer the opportunity to investigate how the brain orchestrates the wide variety of behaviors from the spiking activity of its neurons. One of the most effective methods to monitor spiking activity from a large number of neurons in multiple local neuronal circuits simultaneously is by using silicon electrode arrays. Action potentials produce large transmembrane voltage changes in the vicinity of cell somata. These output signals can be measured by placing a conductor in close proximity of a neuron. If there are many active (spiking) neurons in the vicinity of the tip, the electrode records combined signal from all of them, where contribution of a single neuron is weighted by its 'electrical distance'. Silicon probes are ideal recording electrodes to monitor multiple neurons because of a large number of recording sites (+64) and a small volume. Furthermore, multiple sites can be arranged over a distance of millimeters, thus allowing for the simultaneous recordings of neuronal activity in the various cortical layers or in multiple cortical columns (Fig. 1). Importantly, the geometrically precise distribution of the recording sites also allows for the determination of the spatial relationship of the isolated single neurons. Here, we describe an acute, large-scale neuronal recording from the left and right forelimb somatosensory cortex simultaneously in an anesthetized rat with silicon probes (Fig. 2).
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Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
Schjetnan, Andrea Gomez Palacio; Luczak, Artur
2011-01-01
Large scale electrophysiological recordings from neuronal ensembles offer the opportunity to investigate how the brain orchestrates the wide variety of behaviors from the spiking activity of its neurons. One of the most effective methods to monitor spiking activity from a large number of neurons in multiple local neuronal circuits simultaneously is by using silicon electrode arrays1-3. Action potentials produce large transmembrane voltage changes in the vicinity of cell somata. These output signals can be measured by placing a conductor in close proximity of a neuron. If there are many active (spiking) neurons in the vicinity of the tip, the electrode records combined signal from all of them, where contribution of a single neuron is weighted by its 'electrical distance'. Silicon probes are ideal recording electrodes to monitor multiple neurons because of a large number of recording sites (+64) and a small volume. Furthermore, multiple sites can be arranged over a distance of millimeters, thus allowing for the simultaneous recordings of neuronal activity in the various cortical layers or in multiple cortical columns (Fig. 1). Importantly, the geometrically precise distribution of the recording sites also allows for the determination of the spatial relationship of the isolated single neurons4. Here, we describe an acute, large-scale neuronal recording from the left and right forelimb somatosensory cortex simultaneously in an anesthetized rat with silicon probes (Fig. 2). PMID:22042361
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Cherenkov detectors for spatial imaging applications using discrete-energy photons
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rose, Paul B.; Erickson, Anna S., E-mail: erickson@gatech.edu
Cherenkov detectors can offer a significant advantage in spatial imaging applications when excellent timing response, low noise and cross talk, large area coverage, and the ability to operate in magnetic fields are required. We show that an array of Cherenkov detectors with crude energy resolution coupled with monochromatic photons resulting from a low-energy nuclear reaction can be used to produce a sharp image of material while providing large and inexpensive detector coverage. The analysis of the detector response to relative transmission of photons with various energies allows for reconstruction of material's effective atomic number further aiding in high-Z material identification.
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Large Scale Flutter Data for Design of Rotating Blades Using Navier-Stokes Equations
NASA Technical Reports Server (NTRS)
Guruswamy, Guru P.
2012-01-01
A procedure to compute flutter boundaries of rotating blades is presented; a) Navier-Stokes equations. b) Frequency domain method compatible with industry practice. Procedure is initially validated: a) Unsteady loads with flapping wing experiment. b) Flutter boundary with fixed wing experiment. Large scale flutter computation is demonstrated for rotating blade: a) Single job submission script. b) Flutter boundary in 24 hour wall clock time with 100 cores. c) Linearly scalable with number of cores. Tested with 1000 cores that produced data in 25 hrs for 10 flutter boundaries. Further wall-clock speed-up is possible by performing parallel computations within each case.
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Exposure setup for animal experiments using a parabolic reflector.
Schelkshorn, S; Tejero, S; Detlefsen, J
2007-01-01
The exposure setup presented is intended for a controlled, long-term and continuous exposition (20 Months, 24 h/day) of a large number of animals (100 rats at minimum) with standard GSM and UMTS signals, at 900 MHz and 1966 MHz, respectively. To obtain a homogeneous field within a large volume, the setup is based on the 'compact range' principle well known from antenna measurement facilities to produce a plane wave at relatively short ranges from the reflector. All requirements imposed due to the in vivo nature of the experiment, i.e. air-conditioning and easy access to the cages can be fulfilled.
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Arithmetic Data Cube as a Data Intensive Benchmark
NASA Technical Reports Server (NTRS)
Frumkin, Michael A.; Shabano, Leonid
2003-01-01
Data movement across computational grids and across memory hierarchy of individual grid machines is known to be a limiting factor for application involving large data sets. In this paper we introduce the Data Cube Operator on an Arithmetic Data Set which we call Arithmetic Data Cube (ADC). We propose to use the ADC to benchmark grid capabilities to handle large distributed data sets. The ADC stresses all levels of grid memory by producing 2d views of an Arithmetic Data Set of d-tuples described by a small number of parameters. We control data intensity of the ADC by controlling the sizes of the views through choice of the tuple parameters.
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Zepeda-Mendoza, Marie Lisandra; Bohmann, Kristine; Carmona Baez, Aldo; Gilbert, M Thomas P
2016-05-03
DNA metabarcoding is an approach for identifying multiple taxa in an environmental sample using specific genetic loci and taxa-specific primers. When combined with high-throughput sequencing it enables the taxonomic characterization of large numbers of samples in a relatively time- and cost-efficient manner. One recent laboratory development is the addition of 5'-nucleotide tags to both primers producing double-tagged amplicons and the use of multiple PCR replicates to filter erroneous sequences. However, there is currently no available toolkit for the straightforward analysis of datasets produced in this way. We present DAMe, a toolkit for the processing of datasets generated by double-tagged amplicons from multiple PCR replicates derived from an unlimited number of samples. Specifically, DAMe can be used to (i) sort amplicons by tag combination, (ii) evaluate PCR replicates dissimilarity, and (iii) filter sequences derived from sequencing/PCR errors, chimeras, and contamination. This is attained by calculating the following parameters: (i) sequence content similarity between the PCR replicates from each sample, (ii) reproducibility of each unique sequence across the PCR replicates, and (iii) copy number of the unique sequences in each PCR replicate. We showcase the insights that can be obtained using DAMe prior to taxonomic assignment, by applying it to two real datasets that vary in their complexity regarding number of samples, sequencing libraries, PCR replicates, and used tag combinations. Finally, we use a third mock dataset to demonstrate the impact and importance of filtering the sequences with DAMe. DAMe allows the user-friendly manipulation of amplicons derived from multiple samples with PCR replicates built in a single or multiple sequencing libraries. It allows the user to: (i) collapse amplicons into unique sequences and sort them by tag combination while retaining the sample identifier and copy number information, (ii) identify sequences carrying unused tag combinations, (iii) evaluate the comparability of PCR replicates of the same sample, and (iv) filter tagged amplicons from a number of PCR replicates using parameters of minimum length, copy number, and reproducibility across the PCR replicates. This enables an efficient analysis of complex datasets, and ultimately increases the ease of handling datasets from large-scale studies.
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Martín, Juan F; Casqueiro, Javier; Liras, Paloma
2005-06-01
Many secondary metabolites (e.g. antibiotics and mycotoxins) are toxic to the microorganisms that produce them. The clusters of genes that are responsible for the biosynthesis of secondary metabolites frequently contain genes for resistance to these toxic metabolites, such as different types of multiple drug resistance systems, to avoid suicide of the producer strains. Recently there has been research into the efflux systems of secondary metabolites in bacteria and in filamentous fungi, such as the large number of ATP-binding cassette transporters found in antibiotic-producing Streptomyces species and that are involved in penicillin secretion in Penicillium chrysogenum. A different group of efflux systems, the major facilitator superfamily exporters, occur very frequently in a variety of bacteria that produce pigments or antibiotics (e.g. the cephamycin and thienamycin producers) and in filamentous fungi that produce mycotoxins. Such efflux systems include the CefT exporters that mediate cephalosporin secretion in Acremonium chrysogenum. The evolutionary origin of these efflux systems and their relationship with current resistance determinants in pathogenic bacteria has been analyzed. Genetic improvement of the secretion systems of secondary metabolites in the producer strain has important industrial applications.
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Perry, N; Cheasty, T; Dallman, T; Launders, N; Willshaw, G
2013-10-01
Evaluation of multilocus variable number tandem repeat analysis (MLVA) to subtype all isolates of Vero cytotoxin-producing Escherichia coli O157 phage type 8 in England and Wales. Over a 13 month period from December 2010, 483 isolates of VTEC O157 PT8 were tested by MLVA; 39% were received in the first 4 months of 2011, when infections are generally low. One profile, or single locus variants of it, was present in 249 (52%) isolates but was not common previously. These cases represented a national increase in PT8, associated epidemiologically with soil-contaminated vegetables. Most of the 177 other MLVA profiles were unique to a single isolate. Profiles shared by >1 isolate included cases from two small community, food-borne outbreaks and 11 households. Several shared profiles were found among 23 isolates without known links. Apart from one group, isolates linked to travel abroad had very diverse profiles. Multilocus variable number tandem repeat analysis discriminated apparent sporadic isolates of the same PT and assisted in detection of cases in an emerging national outbreak. Multilocus variable number tandem repeat analysis is an epidemiologically valid complement to surveillance and applicable as a rapid, practical test for large numbers of isolates. © 2013 The Society for Applied Microbiology.
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The PHENIX PbSc calorimeter and its performance
DOE Office of Scientific and Technical Information (OSTI.GOV)
David, G.; Goto, Y.; Kistenev, E.
1997-11-01
The authors have recently completed the production of the 15552 channel PbSc Electromagnetic calorimeter for the PHENIX experiment at RHIC. The design features a single 4 tower module which is repeated throughout and which was produced with a number of QC steps designed to achieve consistent, large light yield in all channels. They present results on uniformity of the calorimeter, accuracy of a cosmic muon based precalibration scheme and test beam performance.
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Application of artificial neural networks to gaming
NASA Astrophysics Data System (ADS)
Baba, Norio; Kita, Tomio; Oda, Kazuhiro
1995-04-01
Recently, neural network technology has been applied to various actual problems. It has succeeded in producing a large number of intelligent systems. In this article, we suggest that it could be applied to the field of gaming. In particular, we suggest that the neural network model could be used to mimic players' characters. Several computer simulation results using a computer gaming system which is a modified version of the COMMONS GAME confirm our idea.
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Schwemin, A. J.
1959-03-17
A generator for producing relatively large currents at high voltages is described. In general, the invention comprises a plurality of capacitors connected in series by a plurality of switches alternately disposed with the capacitors. The above-noted circuit is mounted for movement with respect to contact members and switch closure means so that a load device and power supply are connected across successive numbers of capacitors, while the other capacitors are successively charged with the same power supply.
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The French Huguenots of Colonial South Carolina: Assimilation or Acculturation
1990-01-01
pressure. 4 After the Revocation. many French Protestants left France in large 2 numbers. They fled to Switzerland. Germany. Holland. the British Isles...diversity of Huguenot occupations in the colony, it is probable that not all French Protestants who left France originally came from the wine-growing...or silk-producing districts of France . Therefore. the association of the French ethnic identity with these two products borders on modern-day 25
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Biological Effects of Nuclear Explosions (BENE) Domain Guide
2012-09-01
DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From – To) Technical Report October 2004-April 2005 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER...greatly increased in the nearby region because increasing amounts of contaminated earth and debris are sucked up into the radioactive cloud. In the case...or a denial scenario involving radioisotopes will be non-uniform exposure with various doses and dose rates producing very large variations in
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HBT correlations and charge ratios in multiple production of pions
NASA Astrophysics Data System (ADS)
Bialas, A.; Zalewski, K.
1999-01-01
The influence of the HTB effect on the multiplicity distribution and charge ratios of independently produced pions is studied. It is shown that, for a wide class of models, there is a critical point, where the average number of pions becomes very large and the multiplicity distribution becomes very broad. In this regime unusual charge ratios (“centauros”, “anticentauros”) are strongly enhanced. The prospects for reaching this regime are discussed.
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Verification of immune response optimality through cybernetic modeling.
Batt, B C; Kompala, D S
1990-02-09
An immune response cascade that is T cell independent begins with the stimulation of virgin lymphocytes by antigen to differentiate into large lymphocytes. These immune cells can either replicate themselves or differentiate into plasma cells or memory cells. Plasma cells produce antibody at a specific rate up to two orders of magnitude greater than large lymphocytes. However, plasma cells have short life-spans and cannot replicate. Memory cells produce only surface antibody, but in the event of a subsequent infection by the same antigen, memory cells revert rapidly to large lymphocytes. Immunologic memory is maintained throughout the organism's lifetime. Many immunologists believe that the optimal response strategy calls for large lymphocytes to replicate first, then differentiate into plasma cells and when the antigen has been nearly eliminated, they form memory cells. A mathematical model incorporating the concept of cybernetics has been developed to study the optimality of the immune response. Derived from the matching law of microeconomics, cybernetic variables control the allocation of large lymphocytes to maximize the instantaneous antibody production rate at any time during the response in order to most efficiently inactivate the antigen. A mouse is selected as the model organism and bacteria as the replicating antigen. In addition to verifying the optimal switching strategy, results showing how the immune response is affected by antigen growth rate, initial antigen concentration, and the number of antibodies required to eliminate an antigen are included.
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Relic gravitational waves and extended inflation
NASA Technical Reports Server (NTRS)
Turner, Michael S.; Wilczek, Frank
1990-01-01
In extended inflation, a new version of inflation where the transition from the false-vacuum phase to a radiation-dominated Universe is accomplished by bubble nucleation and percolation, bubble collisions supply a potent-and potentially detectable-source of gravitational waves. The present energy density in relic gravity waves from bubble collisions is expected to be about 10(exp -5) of closure density-many orders of magnitude greater than that of the gravity waves produced by quantum fluctuations. Their characteristic wavelength depends upon the reheating temperature T(sub RH): lambda is approximately 10(exp 4) cm (10(exp 14) GeV/T(sub RH)). If large numbers of black holes are produced, a not implausible outcome, they will evaporate producing comparable amounts of shorter wavelength waves, lambda is approximately 10(exp -6) cm (T(sub RH)/10(exp 14) GeV).
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The vocal monotony of monogamy
NASA Astrophysics Data System (ADS)
Thomas, Jeanette
2003-04-01
There are four phocids in waters around Antarctica: Weddell, leopard, crabeater, and Ross seals. These four species provide a unique opportunity to examine underwater vocal behavior in species sharing the same ecosystem. Some species live in pack ice, others in factice, but all are restricted to the Antarctic or sub-Antarctic islands. All breed and produce vocalizations under water. Social systems range from polygyny in large breeding colonies, to serial monogamy, to solitary species. The type of mating system influences the number of underwater vocalizations in the repertoire, with monogamous seals producing only a single call, polygynous species producing up to 35 calls, and solitary species an intermediate number of about 10 calls. Breeding occurs during the austral spring and each species carves-out an acoustic niche for communicating, with species using different frequency ranges, temporal patterns, and amplitude changes to convey their species-specific calls and presumably reduce acoustic competition. Some species exhibit geographic variations in their vocalizations around the continent, which may reflect discrete breeding populations. Some seals become silent during a vulnerable time of predation by killer whales, perhaps to avoid detection. Overall, vocalizations of these seals exhibit adaptive characteristics that reflect the co-evolution among species in the same ecosystem.
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Artificial cloning of domestic animals
Keefer, Carol L.
2015-01-01
Domestic animals can be cloned using techniques such as embryo splitting and nuclear transfer to produce genetically identical individuals. Although embryo splitting is limited to the production of only a few identical individuals, nuclear transfer of donor nuclei into recipient oocytes, whose own nuclear DNA has been removed, can result in large numbers of identical individuals. Moreover, clones can be produced using donor cells from sterile animals, such as steers and geldings, and, unlike their genetic source, these clones are fertile. In reality, due to low efficiencies and the high costs of cloning domestic species, only a limited number of identical individuals are generally produced, and these clones are primarily used as breed stock. In addition to providing a means of rescuing and propagating valuable genetics, somatic cell nuclear transfer (SCNT) research has contributed knowledge that has led to the direct reprogramming of cells (e.g., to induce pluripotent stem cells) and a better understanding of epigenetic regulation during embryonic development. In this review, I provide a broad overview of the historical development of cloning in domestic animals, of its application to the propagation of livestock and transgenic animal production, and of its scientific promise for advancing basic research. PMID:26195770
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Artificial cloning of domestic animals.
Keefer, Carol L
2015-07-21
Domestic animals can be cloned using techniques such as embryo splitting and nuclear transfer to produce genetically identical individuals. Although embryo splitting is limited to the production of only a few identical individuals, nuclear transfer of donor nuclei into recipient oocytes, whose own nuclear DNA has been removed, can result in large numbers of identical individuals. Moreover, clones can be produced using donor cells from sterile animals, such as steers and geldings, and, unlike their genetic source, these clones are fertile. In reality, due to low efficiencies and the high costs of cloning domestic species, only a limited number of identical individuals are generally produced, and these clones are primarily used as breed stock. In addition to providing a means of rescuing and propagating valuable genetics, somatic cell nuclear transfer (SCNT) research has contributed knowledge that has led to the direct reprogramming of cells (e.g., to induce pluripotent stem cells) and a better understanding of epigenetic regulation during embryonic development. In this review, I provide a broad overview of the historical development of cloning in domestic animals, of its application to the propagation of livestock and transgenic animal production, and of its scientific promise for advancing basic research.
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Constraining the astrophysical origin of the p-nuclei through nuclear physics and meteoritic data.
Rauscher, T; Dauphas, N; Dillmann, I; Fröhlich, C; Fülöp, Zs; Gyürky, Gy
2013-06-01
A small number of naturally occurring, proton-rich nuclides (the p-nuclei) cannot be made in the s- and r-processes. Their origin is not well understood. Massive stars can produce p-nuclei through photodisintegration of pre-existing intermediate and heavy nuclei. This so-called γ-process requires high stellar plasma temperatures and occurs mainly in explosive O/Ne burning during a core-collapse supernova. Although the γ-process in massive stars has been successful in producing a large range of p-nuclei, significant deficiencies remain. An increasing number of processes and sites has been studied in recent years in search of viable alternatives replacing or supplementing the massive star models. A large number of unstable nuclei, however, with only theoretically predicted reaction rates are included in the reaction network and thus the nuclear input may also bear considerable uncertainties. The current status of astrophysical models, nuclear input and observational constraints is reviewed. After an overview of currently discussed models, the focus is on the possibility to better constrain those models through different means. Meteoritic data not only provide the actual isotopic abundances of the p-nuclei but can also put constraints on the possible contribution of proton-rich nucleosynthesis. The main part of the review focuses on the nuclear uncertainties involved in the determination of the astrophysical reaction rates required for the extended reaction networks used in nucleosynthesis studies. Experimental approaches are discussed together with their necessary connection to theory, which is especially pronounced for reactions with intermediate and heavy nuclei in explosive nuclear burning, even close to stability.
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Antia, N H
1990-03-01
The anaesthetic foot in leprosy poses the most major problem in the rehabilitation of its patients. Various attempts have been made to produce protective footwear such as the microcellular rubber-car-tyre sandals. Unfortunately these attempts have had little success on a large scale because of the inability to produce them in large numbers and the stigma attached to such unusual footwear. While such footwear may be superior to the 'tennis' shoe in protecting the foot from injury by the penetration of sharp objects, it fails to distribute the weight-bearing forces which is the major cause of plantar damage and ulceration in the anaesthetic foot. This can be achieved by providing rigidity to the sole, as demonstrated by the healing of ulcers in plaster of paris casts or the rigid wooden clog. A new type of moulded plastic footwear has been evolved in conjunction with the plastic footwear industry which provides footwear that can be mass produced at a low price and which overcomes the stigma of leprosy. Controlled rigidity is provided by the incorporation of a spring steel shank between the sponge insole and the hard wearing plastic sole. Trials have demonstrated both the acceptability of the footwear and its protective effects as well as its hard wearing properties.
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Characterization of BEGe detectors in the HADES underground laboratory
NASA Astrophysics Data System (ADS)
Andreotti, Erica; Gerda Collaboration
2013-08-01
This paper describes the characterization of newly produced Broad Energy Germanium (BEGe) detectors, enriched in the isotope 76Ge. These detectors have been produced in the frame of the GERDA experiment. The aim of the characterization campaign consists in the determination of all the important operational parameters (active volume, dead layer thickness and uniformity, energy resolution, detector stability in time, quality of pulse shape discrimination). A protocol test procedure and devoted set-ups, partially automated, have been developed in view of the large number (∼ 25) of BEGe's detectors to be tested. The characterization is carried out in the HADES underground laboratory, located 225 m below ground (∼ 500 m water equivalent) in Mol, Belgium.
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Electric Dipole Theory of Chemical Synaptic Transmission
Wei, Ling Y.
1968-01-01
In this paper we propose that chemicals such as acetylcholine are electric dipoles which when oriented and arranged in a large array could produce an electric field strong enough to drive positive ions over the junction barrier of the post-synaptic membrane and thus initiate excitation or produce depolarization. This theory is able to explain a great number of facts such as cleft size, synaptic delay, nonregeneration, subthreshold integration, facilitation with repetition, and the calcium and magnesium effects. It also shows why and how acetylcholine could act as excitatory or inhibitory transmitters under different circumstances. Our conclusion is that the nature of synaptic transmission is essentially electrical, be it mediated by electrical or chemical transmitters. PMID:4296121
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de Alwis, M C; Carter, G R; Chengappa, M M
1980-01-01
A large number of streptomycin dependent mutants were produced from bovine haemorrhagic septicaemia strains of Pasteurella multocida. The mutants required a minimum concentration of 25-50 microgram/mL streptomycin for growth and tolerated a concentration of 200 mg/mL. These mutants were avirulent to mice, when inoculated alone, but some mutants killed mice when inoculated with streptomycin. Biochemically all mutants were uniform and similar to the wild type. Most mutants were stable, but a few produced streptomycin independent revertants. The rate of reversion varied with each mutant. Most revertants were highly virulent for mice, some totally avirulant and a few relatively avirulent. PMID:6778598
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Burke, F.; Donoghue, N.
1994-11-01
Vietnam`s energy needs are clear and acute. Economic reforms have triggered a dynamic development process with a large and growing appetite for power. In view of the Vietnamese government`s own shortages of capital, private international power companies have been identified as key problem-solvers in the country`s efforts to meet a skyrocketing demand for energy resources. There are no restrictions on the nature of projects in which non-Vietnamese investors may participate. A number of legal issues need resolution before independent power producers can take advantage of the Republic`s recently created Builder-Operator-Transfer Contracts (the BOT Regulations). This paper discusses these regulations andmore » how they affect independent power producers« less
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Linear optics only allows every possible quantum operation for one photon or one port
NASA Astrophysics Data System (ADS)
Moyano-Fernández, Julio José; Garcia-Escartin, Juan Carlos
2017-01-01
We study the evolution of the quantum state of n photons in m different modes when they go through a lossless linear optical system. We show that there are quantum evolution operators U that cannot be built with linear optics alone unless the number of photons or the number of modes is equal to one. The evolution for single photons can be controlled with the known realization of any unitary proved by Reck, Zeilinger, Bernstein and Bertani. The evolution for a single mode corresponds to the trivial evolution in a phase shifter. We analyze these two cases and prove that any other combination of the number of photons and modes produces a Hilbert state too large for the linear optics system to give any desired evolution.
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Fjield, T; Hynynen, K
2000-01-01
Phased-array technology offers an incredible advantage to therapeutic ultrasound due to the ability to electronically steer foci, create multiple foci, or to create an enlarged focal region by using phase cancellation. However, to take advantage of this flexibility, the phased-arrays generally consist of many elements. Each of these elements requires its own radio-frequency generator with independent amplitude and phase control, resulting in a large, complex, and expensive driving system. A method is presented here where in certain cases the number of amplifier channels can be reduced to a fraction of the number of transducer elements, thereby simplifying the driving system and reducing the overall system complexity and cost, by using isolation transformers to produce 180 degrees phase shifts.
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Sustained >100 MeV Gamma-Ray Emission: A Monitor for >300 MeV SEP Protons at the Sun
NASA Astrophysics Data System (ADS)
Share, G. H.; Murphy, R. J.
2017-12-01
Solar γ radiation is the product of proton and ion interactions in the solar atmosphere. The spectrum and temporal characteristics of the emission provides fundamental information on the ions at the Sun. Until the launch of the Fermi satellite, with its Large Area Telescope (LAT) sensitive to radiation above 100 MeV, most of the γ-ray observations were made in the nuclear energy range with radiation arising from interaction of one to tens of MeV ions produced in solar flares. Since 2008 the LAT has detected 30 high-energy γ-ray events with temporal and spectral characteristics that are distinct from the associated solar flare. We call this radiation Sustained Gamma-Ray Emission (SGRE) and briefly summarize its characteristics reported in a recent paper. The γ-ray spectra are consistent with pion decay radiation produced by protons above 300 MeV. The onset of the radiation most often occurs after the impulsive flare and the emission can last several hours. We find that the number of protons responsible for the SGRE is typically more than 10 times the number of flare-accelerated protons. These characteristics require that there be an additional source of energy to accelerate the protons to hundreds of MeV to produce the SGRE. As 28 of the 30 SGRE events are accompanied by fast CMEs, it is likely that these protons are accelerated by the same shock that produces gradual SEPs. We find that the number of protons >500 MeV in the accompanying SEPs is typically about 50-100 times the number of protons that return to the Sun to produce the SGRE. There also appear to be correlations between the numbers of SEP and SGRE protons and durations of >100 MeV SEP proton and SGRE events. We find that for all SGRE events where there were flare observations, the accompanying impulsive X-radiation reached energies >100 keV. In a limited study of 18 solar events with CME speeds >800 km/s we also find that the median SEP proton flux is 25 times higher when flare hard X-rays exceed 100 keV. We argue that >100 keV flare X-ray emission is a signature for the presence of hundreds of keV electrons and ions in flares, some of which escape to form a seed population accelerated by CME shocks to produce both the SGRE and the accompanying SEP. This can explain why high-energy SEPs appear to be produced in more significant numbers when a fast CME is accompanied by a flare emitting X-rays >100 keV.
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Mitigating Large Fires in Drossel-Schwabl Forest Fire Models
NASA Astrophysics Data System (ADS)
Yoder, M.; Turcotte, D.; Rundle, J.; Morein, G.
2008-12-01
We employ variations of the traditional Drossel-Schwabl cellular automata Forest Fire Models (FFM) to study wildfire dynamics. The traditional FFM produces a very robust power law distribution of events, as a function of size, with frequency-size slope very close to -1. Observed data from Australia, the US and northern Mexico suggest that real wild fires closely follow power laws in frequency size with slopes ranging from close to -2 to -1.3 (B.D. Malamud et al. 2005). We suggest two models that, by fracturing and trimming large clusters, reduce the number of large fires while maintaining scale invariance. These fracturing and trimming processes can be justified in terms of real physical processes. For each model, we achieve slopes in the frequency-size relation ranging from approximately -1.77 to -1.06.
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Strategies for Analyzing Sub-Micrometer Features with the FE-EPMA
NASA Astrophysics Data System (ADS)
McSwiggen, P.; Armstrong, J. T.; Nielsen, C.
2013-12-01
Changes in column design and electronics, as well as new types of spectrometers and analyzing crystals, have significantly advanced electron microprobes, in terms of stability, reproducibility and detection limits. A major advance in spatial resolution has occurred through the use of the field emission electron gun. The spatial resolution of an analysis is controlled by the diameter of the electron beam and the amount of scatter that takes place within the sample. The beam diameter is controlled by the column and type of electron gun being used. The accelerating voltage and the average atomic number/density of the sample control the amount of electron scatter within the sample. However a large electron interaction volume does not necessarily mean a large analytical volume. The beam electrons may spread out within a large volume, but if the electrons lack sufficient energy to produce the X-ray of interest, the analytical volume could be significantly smaller. Therefore there are two competing strategies for creating the smallest analytical volumes. The first strategy is to reduce the accelerating voltage to produce the smallest electron interaction volume. This low kV analytical approach is ultimately limited by the size of the electron beam itself. With a field emission gun, normally the smallest analytical area is achieved at around 5-7 kV. At lower accelerating voltages, the increase in the beam diameter begins to overshadow the reduction in internal scattering. For tungsten filament guns, the smallest analytical volume is reached at higher accelerating voltages. The second strategy is to minimize the overvoltage during the analysis. If the accelerating voltage is only 1-3 kV greater than the critical ionization energy for the X-ray line of interest, then even if the overall electron interaction volume is large, those electrons quickly loose sufficient energy to produce the desired X-rays. The portion of the interaction volume in which the desired X-rays will be produce will be very small and very near the surface. Both strategies have advantages and disadvantages depending on the ultimate goal of the analysis and the elements involved. This work will examine a number of considerations when attempting to decide which approach is best for a given analytical situation. These include: (1) the size of the analytical volumes, (2) minimum detection limits, (3) quality of the matrix corrections, (4) secondary fluorescence, (5) effects of surface contamination, oxide layers, and carbon coatings. This work is based on results largely from the Fe-Ni binary. A simple conclusion cannot be draw as to which strategy is better overall. The determination is highly system dependent. For many mineral systems, both strategies used in combination will produce the best results. Using multiple accelerating voltages to preform a single analysis allows the analyst to optimize their analytical conditions for each element individually.
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Reimann-Philipp, R
1968-01-01
1. In the diploid petunias of the class ofgrandiflora the dominant alleleG at thegrandiflora locus which determines the character of large flowers is normally linked to a recessive lethal genel which eliminates zygotes and simultaneously diminishes the chance of fertilization of the pollen transferring it. Large flowered petunia plants in the class ofgrandiflora are therefore normally heterozygous with respect to the alleles of thegrandiflora locus and have the genotypeGl/gL. Grandiflora homozygotesGl/GL orGL/GL originate from rare crossover events, and so does the genotypeGL/gl. 2. Since the very bright leaf color of thegrandiflora homozygotes reduces their vigor, the breeding of homozygous large flowered varieties has no practical importance. A special interest therefore arises for the genotypeGL/gl because, in spite of heterozygosity, the offspring do not include undesirable small-flowered plants with the exception of some originating from rare combinations of crossover gametes. 3. The tetraploid genotypeGL/GL/gl/gl was produced by colchicine treatment. Analysis of the offsprings of the next two generations showed that in tetraploid material the zygotic effect of the lethal gene works in the same way as in diploids, producing again automatic elimination of small-flowered plants. Moreover, it was found that gametes of the genotypegl/gl can be transferred not only by egg-cells but also by the pollen. 4. Consequently, it is possible to achieve an automatic elimination of the small-flowered plants also in the tetraploid class ofsuperbissima. This may be done by replacing the linkage groupgL ofsuperbissima petunias by thegl type of the artificially produced new tetraploid material. Homozygous large-flowered plants do not occur in tetraploid material because gametes of the genotypeGG are not transferable by the pollen. 5. Particularly the above mentioned qualities, that is the crossability to tetraploid petunias of the class ofsuperbissima and the possibility of transferring some desired characters, as for example the linkage groupgl or the yellow flower color to the latter, determine the value of the newly produced tetraploid material. Since some of the typical characters ofSuperbissima petunias, particularly those concerning flower shape, do not occur in the new tetraploid material the latter is of no direct ornamental interest, except for the yellow-flowered lines. 6. The alleleG which produces large flowers both insuperbissima and in the new tetraploid material brightens, in addition, the leaf color in the new tetraploid material. Since the degree of brightness increases with the number ofG alleles in the genotype, it is rather easy to identify the different tetraploid heterozygotes in the new material. 7. Yellow-flowered lines were also produced as starting material for the polyploidization of the genotypeGL/gl. Tetraploid yellow-flowered lines were produced in order to examine whether the tint of the yellow flower color, unsatisfactory in large-flowered diploid varieties, could be intensified by tetraploidy. Because the yellow flower color did occur insuperbissima, the newly produced tetraploid yellow-flowered material is important also for transmission of this character to the latter. The experiments showed that the intensity of yellow flower color in the new tetraploid yellow-flowered and very large-flowered material still does not reach that of modern diploid small-floweredmultiflora petunias. However, for the production of both practically pure, large, and yellow-flowered tetraploid varieties and of tetraploid large and yellow-flowered F1-hybrids the new material offers interesting possibilities, which are discussed in detail.
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Design of a fast computer-based partial discharge diagnostic system
NASA Technical Reports Server (NTRS)
Oliva, Jose R.; Karady, G. G.; Domitz, Stan
1991-01-01
Partial discharges cause progressive deterioration of insulating materials working in high voltage conditions and may lead ultimately to insulator failure. Experimental findings indicate that deterioration increases with the number of discharges and is consequently proportional to the magnitude and frequency of the applied voltage. In order to obtain a better understanding of the mechanisms of deterioration produced by partial discharges, instrumentation capable of individual pulse resolution is required. A new computer-based partial discharge detection system was designed and constructed to conduct long duration tests on sample capacitors. This system is capable of recording large number of pulses without dead time and producing valuable information related to amplitude, polarity, and charge content of the discharges. The operation of the system is automatic and no human supervision is required during the testing stage. Ceramic capacitors were tested at high voltage in long duration tests. The obtained results indicated that the charge content of partial discharges shift towards high levels of charge as the level of deterioration in the capacitor increases.
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Gravitational waves from vacuum first-order phase transitions: From the envelope to the lattice
NASA Astrophysics Data System (ADS)
Cutting, Daniel; Hindmarsh, Mark; Weir, David J.
2018-06-01
We conduct large scale numerical simulations of gravitational wave production at a first-order vacuum phase transition. We find a power law for the gravitational wave power spectrum at high wave number which falls off as k-1.5 rather than the k-1 produced by the envelope approximation. The peak of the power spectrum is shifted to slightly lower wave numbers from that of the envelope approximation. The envelope approximation reproduces our results for the peak power less well, agreeing only to within an order of magnitude. After the bubbles finish colliding, the scalar field oscillates around the true vacuum. An additional feature is produced in the UV of the gravitational wave power spectrum, and this continues to grow linearly until the end of our simulation. The additional feature peaks at a length scale close to the bubble wall thickness and is shown to have a negligible contribution to the energy in gravitational waves, providing the scalar field mass is much smaller than the Planck mass.
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Novel anti-infective compounds from marine bacteria.
Rahman, Hafizur; Austin, Brian; Mitchell, Wilfrid J; Morris, Peter C; Jamieson, Derek J; Adams, David R; Spragg, Andrew Mearns; Schweizer, Michael
2010-03-05
As a result of the continuous evolution of microbial pathogens towards antibiotic-resistance, there have been demands for the development of new and effective antimicrobial compounds. Since the 1960s, the scientific literature has accumulated many publications about novel pharmaceutical compounds produced by a diverse range of marine bacteria. Indeed, marine micro-organisms continue to be a productive and successful focus for natural products research, with many newly isolated compounds possessing potentially valuable pharmacological activities. In this regard, the marine environment will undoubtedly prove to be an increasingly important source of novel antimicrobial metabolites, and selective or targeted approaches are already enabling the recovery of a significant number of antibiotic-producing micro-organisms. The aim of this review is to consider advances made in the discovery of new secondary metabolites derived from marine bacteria, and in particular those effective against the so called "superbugs", including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), which are largely responsible for the increase in numbers of hospital acquired, i.e., nosocomial, infections.
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Computational exploration of neuron and neural network models in neurobiology.
Prinz, Astrid A
2007-01-01
The electrical activity of individual neurons and neuronal networks is shaped by the complex interplay of a large number of non-linear processes, including the voltage-dependent gating of ion channels and the activation of synaptic receptors. These complex dynamics make it difficult to understand how individual neuron or network parameters-such as the number of ion channels of a given type in a neuron's membrane or the strength of a particular synapse-influence neural system function. Systematic exploration of cellular or network model parameter spaces by computational brute force can overcome this difficulty and generate comprehensive data sets that contain information about neuron or network behavior for many different combinations of parameters. Searching such data sets for parameter combinations that produce functional neuron or network output provides insights into how narrowly different neural system parameters have to be tuned to produce a desired behavior. This chapter describes the construction and analysis of databases of neuron or neuronal network models and describes some of the advantages and downsides of such exploration methods.
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Breeding ecology of the Puaiohi (Myadestes palmeri)
Snetsinger, T.J.; Herrmann, C.M.; Holmes, D.E.; Hayward, C.D.; Fancy, S.G.
2005-01-01
We studied the breeding ecology of the critically endangered Puaiohi (Myadestes palmeri), a poorly known Hawaiian thrush endemic to the island of Kauai. From 1996 through 1998, we monitored 96 active nests over the course of three breeding seasons. Mean clutch size was 2.0, and pairs produced an average of 1.5 fledglings/successful nest. Pairs renested after failure and some raised multiple broods. The mean annual reproductive effort was 2.1 nesting attempts/territory, and pairs produced a mean 1.1 fledglings/attempt. Large differences in nesting effort and productivity occurred among years, with mean number of fledglings/territory ranging from 0.4 to 4.9. Predation by owls (probably Short-eared Owls, Asia flammeus) and introduced rats (probably black rats, Rattus rattus) accounted for most nest failures. The presence of non-breeding floaters in the population and their largely unsuccessful attempts to gain territories in the study area suggest that the population is near carrying capacity. The high reproductive potential of the Puaiohi may help explain its persistence despite the species' historical rarity.
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A Ruby in the Rubbish: Beneficial Mutations, Deleterious Mutations and the Evolution of Sex
Peck, J. R.
1994-01-01
This study presents a mathematical model in which a single beneficial mutation arises in a very large population that is subject to frequent deleterious mutations. The results suggest that, if the population is sexual, then the deleterious mutations will have little effect on the ultimate fate of the beneficial mutation. However, if most offspring are produced asexually, then the probability that the beneficial mutation will be lost from the population may be greatly enhanced by the deleterious mutations. Thus, sexual populations may adapt much more quickly than populations where most reproduction is asexual. Some of the results were produced using computer simulation methods, and a technique was developed that allows treatment of arbitrarily large numbers of individuals in a reasonable amount of computer time. This technique may be of prove useful for the analysis of a wide variety of models, though there are some constraints on its applicability. For example, the technique requires that reproduction can be described by Poisson processes. PMID:8070669
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Assessing Volunteered Geographic Information (vgi) Quality Based on CONTRIBUTORS' Mapping Behaviours
NASA Astrophysics Data System (ADS)
Bégin, D.; Devillers, R.; Roche, S.
2013-05-01
VGI changed the mapping landscape by allowing people that are not professional cartographers to contribute to large mapping projects, resulting at the same time in concerns about the quality of the data produced. While a number of early VGI studies used conventional methods to assess data quality, such approaches are not always well adapted to VGI. Since VGI is a user-generated content, we posit that features and places mapped by contributors largely reflect contributors' personal interests. This paper proposes studying contributors' mapping processes to understand the characteristics and quality of the data produced. We argue that contributors' behaviour when mapping reflects contributors' motivation and individual preferences in selecting mapped features and delineating mapped areas. Such knowledge of contributors' behaviour could allow for the derivation of information about the quality of VGI datasets. This approach was tested using a sample area from OpenStreetMap, leading to a better understanding of data completeness for contributor's preferred features.
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Balasubramaniam, Saranya C; Mohney, Brian G; Bang, Genie M; Link, Thomas P; Pulido, Jose S
2012-09-01
The purpose of this article is to demonstrate the utility of the large spot size (LSS) setting using a binocular laser indirect delivery system for peripheral ablation in children. One patient with bilateral retinopathy of prematurity received photocoagulation with standard spot size burns placed adjacently to LSS burns. Using a pixel analysis program called Image J on the Retcam picture, the areas of each retinal spot size were determined in units of pixels, giving a standard spot range of 805 to 1294 pixels and LSS range of 1699 to 2311 pixels. Additionally, fluence was calculated using theoretical retinal areas produced by each spot size: the standard spot setting was 462 mJ/mm2 and the LSS setting was 104 mJ/mm2. For eyes with retinopathy of prematurity, our study shows that LSS laser indirect delivery halves the number of spots required for treatment and reduces fluence by almost one-quarter, producing more uniform spots.
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Exact CNOT gates with a single nonlocal rotation for quantum-dot qubits
NASA Astrophysics Data System (ADS)
Pal, Arijeet; Rashba, Emmanuel I.; Halperin, Bertrand I.
2015-09-01
We investigate capacitively-coupled exchange-only two-qubit quantum gates based on quantum dots. For exchange-only coded qubits electron spin S and its projection Sz are exact quantum numbers. Capacitive coupling between qubits, as distinct from interqubit exchange, preserves these quantum numbers. We prove, both analytically and numerically, that conservation of the spins of individual qubits has a dramatic effect on the performance of two-qubit gates. By varying the level splittings of individual qubits, Ja and Jb, and the interqubit coupling time, t , we can find an infinite number of triples (Ja,Jb,t ) for which the two-qubit entanglement, in combination with appropriate single-qubit rotations, can produce an exact cnot gate. This statement is true for practically arbitrary magnitude and form of capacitive interqubit coupling. Our findings promise a large decrease in the number of nonlocal (two-qubit) operations in quantum circuits.
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The key role of dry days in changing regional climate and precipitation regimes
Polade, Suraj; Pierce, David W.; Cayan, Daniel R.; Gershunov, Alexander; Dettinger, Michael D.
2014-01-01
Future changes in the number of dry days per year can either reinforce or counteract projected increases in daily precipitation intensity as the climate warms. We analyze climate model projected changes in the number of dry days using 28 coupled global climate models from the Coupled Model Intercomparison Project, version 5 (CMIP5). We find that the Mediterranean Sea region, parts of Central and South America, and western Indonesia could experience up to 30 more dry days per year by the end of this century. We illustrate how changes in the number of dry days and the precipitation intensity on precipitating days combine to produce changes in annual precipitation, and show that over much of the subtropics the change in number of dry days dominates the annual changes in precipitation and accounts for a large part of the change in interannual precipitation variability.
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One step screening of retroviral producer clones by real time quantitative PCR.
Towers, G J; Stockholm, D; Labrousse-Najburg, V; Carlier, F; Danos, O; Pagès, J C
1999-01-01
Recombinant retroviruses are obtained from either stably or transiently transfected retrovirus producer cells. In the case of stably producing lines, a large number of clones must be screened in order to select the one with the highest titre. The multi-step selection of high titre producing clones is time consuming and expensive. We have taken advantage of retroviral endogenous reverse transcription to develop a quantitative PCR assay on crude supernatant from producing clones. We used Taqman PCR technology, which, by using fluorescence measurement at each cycle of amplification, allows PCR product quantification. Fluorescence results from specific degradation of a probe oligonucleotide by the Taq polymerase 3'-5' exonuclease activity. Primers and probe sequences were chosen to anneal to the viral strong stop species, which is the first DNA molecule synthesised during reverse transcription. The protocol consists of a single real time PCR, using as template filtered viral supernatant without any other pre-treatment. We show that the primers and probe described allow quantitation of serially diluted plasmid to as few as 15 plasmid molecules. We then test 200 GFP-expressing retroviral-producing clones either by FACS analysis of infected cells or by using the quantitative PCR. We confirm that the Taqman protocol allows the detection of virus in supernatant and selection of high titre clones. Furthermore, we can determine infectious titre by quantitative PCR on genomic DNA from infected cells, using an additional set of primers and probe to albumin to normalise for the genomic copy number. We demonstrate that real time quantitative PCR can be used as a powerful and reliable single step, high throughput screen for high titre retroviral producer clones.
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Statistical Ensemble of Large Eddy Simulations
NASA Technical Reports Server (NTRS)
Carati, Daniele; Rogers, Michael M.; Wray, Alan A.; Mansour, Nagi N. (Technical Monitor)
2001-01-01
A statistical ensemble of large eddy simulations (LES) is run simultaneously for the same flow. The information provided by the different large scale velocity fields is used to propose an ensemble averaged version of the dynamic model. This produces local model parameters that only depend on the statistical properties of the flow. An important property of the ensemble averaged dynamic procedure is that it does not require any spatial averaging and can thus be used in fully inhomogeneous flows. Also, the ensemble of LES's provides statistics of the large scale velocity that can be used for building new models for the subgrid-scale stress tensor. The ensemble averaged dynamic procedure has been implemented with various models for three flows: decaying isotropic turbulence, forced isotropic turbulence, and the time developing plane wake. It is found that the results are almost independent of the number of LES's in the statistical ensemble provided that the ensemble contains at least 16 realizations.
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Finite difference and Runge-Kutta methods for solving vibration problems
NASA Astrophysics Data System (ADS)
Lintang Renganis Radityani, Scolastika; Mungkasi, Sudi
2017-11-01
The vibration of a storey building can be modelled into a system of second order ordinary differential equations. If the number of floors of a building is large, then the result is a large scale system of second order ordinary differential equations. The large scale system is difficult to solve, and if it can be solved, the solution may not be accurate. Therefore, in this paper, we seek for accurate methods for solving vibration problems. We compare the performance of numerical finite difference and Runge-Kutta methods for solving large scale systems of second order ordinary differential equations. The finite difference methods include the forward and central differences. The Runge-Kutta methods include the Euler and Heun methods. Our research results show that the central finite difference and the Heun methods produce more accurate solutions than the forward finite difference and the Euler methods do.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Fishkind, H.H.
1982-04-01
The feasibility of large-scale plantation establishment by various methods was examined, and the following conclusions were reached: seedling plantations are limited in potential yield due to genetic variation among the planting stock and often inadequate supplies of appropriate seed; vegetative propagation by rooted cuttings can provide good genetic uniformity of select hybrid planting stock; however, large-scale production requires establishment and maintenance of extensive cutting orchards. The collection of shoots and preparation of cuttings, although successfully implemented in the Congo and Brazil, would not be economically feasible in Florida for large-scale plantations; tissue culture propagation of select hybrid eucalypts offers themore » only opportunity to produce the very large number of trees required to establish the energy plantation. The cost of tissue culture propagation, although higher than seedling production, is more than off-set by the increased productivity of vegetative plantations established from select hybrid Eucalyptus.« less
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Forecasting production in Liquid Rich Shale plays
NASA Astrophysics Data System (ADS)
Nikfarman, Hanieh
Production from Liquid Rich Shale (LRS) reservoirs is taking center stage in the exploration and production of unconventional reservoirs. Production from the low and ultra-low permeability LRS plays is possible only through multi-fractured horizontal wells (MFHW's). There is no existing workflow that is applicable to forecasting multi-phase production from MFHW's in LRS plays. This project presents a practical and rigorous workflow for forecasting multiphase production from MFHW's in LRS reservoirs. There has been much effort in developing workflows and methodology for forecasting in tight/shale plays in recent years. The existing workflows, however, are applicable only to single phase flow, and are primarily used in shale gas plays. These methodologies do not apply to the multi-phase flow that is inevitable in LRS plays. To account for complexities of multiphase flow in MFHW's the only available technique is dynamic modeling in compositional numerical simulators. These are time consuming and not practical when it comes to forecasting production and estimating reserves for a large number of producers. A workflow was developed, and validated by compositional numerical simulation. The workflow honors physics of flow, and is sufficiently accurate while practical so that an analyst can readily apply it to forecast production and estimate reserves in a large number of producers in a short period of time. To simplify the complex multiphase flow in MFHW, the workflow divides production periods into an initial period where large production and pressure declines are expected, and the subsequent period where production decline may converge into a common trend for a number of producers across an area of interest in the field. Initial period assumes the production is dominated by single-phase flow of oil and uses the tri-linear flow model of Erdal Ozkan to estimate the production history. Commercial software readily available can simulate flow and forecast production in this period. In the subsequent Period, dimensionless rate and dimensionless time functions are introduced that help identify transition from initial period into subsequent period. The production trends in terms of the dimensionless parameters converge for a range of rock permeability and stimulation intensity. This helps forecast production beyond transition to the end of life of well. This workflow is applicable to single fluid system.
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Hydration and rotational diffusion of levoglucosan in aqueous solutions
NASA Astrophysics Data System (ADS)
Corezzi, S.; Sassi, P.; Paolantoni, M.; Comez, L.; Morresi, A.; Fioretto, D.
2014-05-01
Extended frequency range depolarized light scattering measurements of water-levoglucosan solutions are reported at different concentrations and temperatures to assess the effect of the presence and distribution of hydroxyl groups on the dynamics of hydration water. The anhydro bridge, reducing from five to three the number of hydroxyl groups with respect to glucose, considerably affects the hydration properties of levoglucosan with respect to those of mono and disaccharides. In particular, we find that the average retardation of water dynamics is ≈3-4, that is lower than ≈5-6 previously found in glucose, fructose, trehalose, and sucrose. Conversely, the average number of retarded water molecules around levoglucosan is 24, almost double that found in water-glucose mixtures. These results suggest that the ability of sugar molecules to form H-bonds through hydroxyl groups with surrounding water, while producing a more effective retardation, it drastically reduces the spatial extent of the perturbation on the H-bond network. In addition, the analysis of the concentration dependence of the hydration number reveals the aptitude of levoglucosan to produce large aggregates in solution. The analysis of shear viscosity and rotational diffusion time suggests a very short lifetime for these aggregates, typically faster than ≈20 ps.
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Inverse sampling regression for pooled data.
Montesinos-López, Osval A; Montesinos-López, Abelardo; Eskridge, Kent; Crossa, José
2017-06-01
Because pools are tested instead of individuals in group testing, this technique is helpful for estimating prevalence in a population or for classifying a large number of individuals into two groups at a low cost. For this reason, group testing is a well-known means of saving costs and producing precise estimates. In this paper, we developed a mixed-effect group testing regression that is useful when the data-collecting process is performed using inverse sampling. This model allows including covariate information at the individual level to incorporate heterogeneity among individuals and identify which covariates are associated with positive individuals. We present an approach to fit this model using maximum likelihood and we performed a simulation study to evaluate the quality of the estimates. Based on the simulation study, we found that the proposed regression method for inverse sampling with group testing produces parameter estimates with low bias when the pre-specified number of positive pools (r) to stop the sampling process is at least 10 and the number of clusters in the sample is also at least 10. We performed an application with real data and we provide an NLMIXED code that researchers can use to implement this method.
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NASA Astrophysics Data System (ADS)
Saha, Abhijit; Vivas, A. Katherina
2017-12-01
Ongoing and future surveys with repeat imaging in multiple bands are producing (or will produce) time-spaced measurements of brightness, resulting in the identification of large numbers of variable sources in the sky. A large fraction of these are periodic variables: compilations of these are of scientific interest for a variety of purposes. Unavoidably, the data sets from many such surveys not only have sparse sampling, but also have embedded frequencies in the observing cadence that beat against the natural periodicities of any object under investigation. Such limitations can make period determination ambiguous and uncertain. For multiband data sets with asynchronous measurements in multiple passbands, we wish to maximally use the information on periodicity in a manner that is agnostic of differences in the light-curve shapes across the different channels. Given large volumes of data, computational efficiency is also at a premium. This paper develops and presents a computationally economic method for determining periodicity that combines the results from two different classes of period-determination algorithms. The underlying principles are illustrated through examples. The effectiveness of this approach for combining asynchronously sampled measurements in multiple observables that share an underlying fundamental frequency is also demonstrated.
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Cocaine Self-Administration Produces a Persistent Increase in Dopamine D2High Receptors
Briand, Lisa A.; Flagel, Shelly B.; Seeman, Philip; Robinson, Terry E.
2008-01-01
Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors. However, in rodents, repeated cocaine administration consistently produces hypersensitivity to the psychomotor activating effects of both indirect dopamine agonists, such as cocaine itself, and importantly, to direct-acting D2 receptor agonists. The current study reports a possible resolution to this long-standing paradox. The dopamine D2 receptor exists in both a low and a high affinity state, and dopamine exerts its effects via the more functionally relevant high-affinity D2 receptor (D2High). We report here that cocaine self-administration experience produces a large (approximately 150%) increase in the proportion of D2High receptors in the striatum with no change in the total number of D2 receptors, and this effect is evident both 3 and 30 days after the discontinuation of cocaine self-administration. Changes in D2High receptors would not be evident with the probes used in human (and non-human primate) imaging studies. We suggest, therefore, that cocaine addicts and animals previously treated with cocaine may be hyper-responsive to dopaminergic drugs in part because an increase in D2High receptors results in dopamine supersensitivity. This may also help explain why stimuli that increase dopamine neurotransmission, including drugs themselves, are so effective in producing relapse in individuals with a history of exposure to cocaine. PMID:18284941
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Single Wall Carbon Nanotube Alignment Mechanisms for Non-Destructive Evaluation
NASA Technical Reports Server (NTRS)
Hong, Seunghun
2002-01-01
As proposed in our original proposal, we developed a new innovative method to assemble millions of single wall carbon nanotube (SWCNT)-based circuit components as fast as conventional microfabrication processes. This method is based on surface template assembly strategy. The new method solves one of the major bottlenecks in carbon nanotube based electrical applications and, potentially, may allow us to mass produce a large number of SWCNT-based integrated devices of critical interests to NASA.
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Dynamic Domains in Data Production Planning
NASA Technical Reports Server (NTRS)
Golden, Keith; Pang, Wanlin
2005-01-01
This paper discusses a planner-based approach to automating data production tasks, such as producing fire forecasts from satellite imagery and weather station data. Since the set of available data products is large, dynamic and mostly unknown, planning techniques developed for closed worlds are unsuitable. We discuss a number of techniques we have developed to cope with data production domains, including a novel constraint propagation algorithm based on planning graphs and a constraint-based approach to interleaved planning, sensing and execution.
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2013-03-20
Wakefield of the University of Michigan as Co-PI. This extended activity produced a large number of products and accomplishments; however, this report...speech communication will be expanded to provide a robust modeling and prediction capability for tasks involving speech production and speech and non...preparations made to move to the newer Cocoa API instead of the previous Carbon API. In the following sections, an extended treatment will be
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Taylor, Jack R.
1987-01-01
A combustor having an annular first stage, a generally cylindrically-shaped second stage, and an annular conduit communicably connecting the first and second stages. The conduit has a relatively small annular height and a large number of quench holes in the walls thereof such that quench air injected into the conduit through the quench holes will mix rapidly with, or quench, the combustion gases flowing through the conduit. The rapid quenching reduces the amount of NO.sub.x produced in the combustor.
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Thompson, D F; Carter, J R
1993-01-01
Gynecomastia is a relatively common physical finding in men. A wide variety of drugs have been implicated in its cause. Sufficient evidence in the literature suggests that calcium-channel blockers, cancer chemotherapeutic agents, and histamine2-receptor blockers may play a role in the disorder. Evidence for digitalis glycosides and neuroleptic agents is insufficient. Ketoconazole and spironolactone can also produce gynecomastia, and data for marijuana are contradictory. Large numbers of drugs have only case reports of temporal association with the disorder.
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NASA Astrophysics Data System (ADS)
Preusker, F.; Oberst, J.; Stark, A.; Burmeister, S.
2018-04-01
We produce high-resolution (222 m/grid element) Digital Terrain Models (DTMs) for Mercury using stereo images from the MESSENGER orbital mission. We have developed a scheme to process large numbers, typically more than 6000, images by photogrammetric techniques, which include, multiple image matching, pyramid strategy, and bundle block adjustments. In this paper, we present models for map quadrangles of the southern hemisphere H11, H12, H13, and H14.
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Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas.
Adrian, T E; Allen, J M; Terenghi, G; Bacarese-Hamilton, A J; Brown, M J; Polak, J M; Bloom, S R
1983-09-03
Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straightforward to measure and relatively stable, its estimation may prove helpful as a screening tests for phaeochromocytoma.
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Aircraft-type dependency of contrail evolution
NASA Astrophysics Data System (ADS)
Unterstrasser, S.; Görsch, N.
2014-12-01
The impact of aircraft type on contrail evolution is assessed using a large eddy simulation model with Lagrangian ice microphysics. Six different aircraft ranging from the small regional airliner Bombardier CRJ to the largest aircraft Airbus A380 are taken into account. Differences in wake vortex properties and fuel flow lead to considerable variations in the early contrail geometric depth and ice crystal number. Larger aircraft produce contrails with more ice crystals (assuming that the number of initially generated ice crystals per kilogram fuel is constant). These initial differences are reduced in the first minutes, as the ice crystal loss during the vortex phase is stronger for larger aircraft. In supersaturated air, contrails of large aircraft are much deeper after 5 min than those of small aircraft. A parameterization for the final vertical displacement of the wake vortex system is provided, depending only on the initial vortex circulation and stratification. Cloud resolving simulations are used to examine whether the aircraft-induced initial differences have a long-lasting mark. These simulations suggest that the synoptic scenario controls the contrail cirrus evolution qualitatively. However, quantitative differences between the contrail cirrus properties of the various aircraft remain over the total simulation period of 6 h. The total extinctions of A380-produced contrails are about 1.5 to 2.5 times higher than those from contrails of a Bombardier CRJ.
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A miniature Marine Aerosol Reference Tank (miniMART) as a compact breaking wave analogue
NASA Astrophysics Data System (ADS)
Stokes, M. Dale; Deane, Grant; Collins, Douglas B.; Cappa, Christopher; Bertram, Timothy; Dommer, Abigail; Schill, Steven; Forestieri, Sara; Survilo, Mathew
2016-09-01
In order to understand the processes governing the production of marine aerosols, repeatable, controlled methods for their generation are required. A new system, the miniature Marine Aerosol Reference Tank (miniMART), has been designed after the success of the original MART system, to approximate a small oceanic spilling breaker by producing an evolving bubble plume and surface foam patch. The smaller tank utilizes an intermittently plunging jet of water produced by a rotating water wheel, into an approximately 6 L reservoir to simulate bubble plume and foam formation and generate aerosols. This system produces bubble plumes characteristic of small whitecaps without the large external pump inherent in the original MART design. Without the pump it is possible to easily culture delicate planktonic and microbial communities in the bulk water during experiments while continuously producing aerosols for study. However, due to the reduced volume and smaller plunging jet, the absolute numbers of particles generated are approximately an order of magnitude less than in the original MART design.
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Winger, A M; Heazlewood, J L; Chan, L J G; Petzold, C J; Permaul, K; Singh, S
2014-11-01
Thermomyces lanuginosus is a thermophilic fungus known for its ability to produce industrially important enzymes including large amounts of xylanase, the key enzyme in hemicellulose hydrolysis. The secretome of T. lanuginosus SSBP was profiled by shotgun proteomics to elucidate important enzymes involved in hemicellulose saccharification and to characterise the presence of other industrially interesting enzymes. This study reproducibly identified a total of 74 proteins in the supernatant following growth on corn cobs. An analysis of proteins revealed nine glycoside hydrolase (GH) enzymes including xylanase GH11, β-xylosidase GH43, β-glucosidase GH3, α-galactosidase GH36 and trehalose hydrolase GH65. Two commercially produced Thermomyces enzymes, lipase and amylase, were also identified. In addition, other industrially relevant enzymes not currently explored in Thermomyces were identified including glutaminase, fructose-bisphosphate aldolase and cyanate hydratase. Overall, these data provide insight into the novel ability of a cellulase-free fungus to utilise lignocellulosic material, ultimately producing a number of enzymes important to various industrial processes.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhang, W.; Chang, Q.G.; Liu, W.D.
A series of follow-up investigations were performed to produce data for improving the four-indicator carbon selection method that we developed to identify high-potential activated carbons effective for removing specific organic water pollutants. The carbon's pore structure and surface chemistry are dependent on the raw material and the activation process. Coconut carbons have relatively more small pores than large pores; coal and apricot nutshell/walnut shell fruit carbons have the desirable pore structures for removing adsorbates of all sizes. Chemical activation, excessive activation, and/or thermal reactivation enlarge small pores, resulting in reduced phenol number and higher tannic acid number. Activated carbon's phenol,more » iodine, methylene blue, and tannic acid numbers are convenient indicators of its surface area and pore volume of pore diameters < 10, 10-15, 15-28, and > 28 angstrom, respectively. The phenol number of a carbon is also a good indicator of its surface acidity of oxygen-containing organic functional groups that affect the adsorptive capacity for aromatic and other small polar organics. The tannic acid number is an indicator of carbon's capacity for large, high-molecular-weight natural organic precursors of disinfection by-products in water treatment. The experimental results for removing nitrobenzene, methyl-tert-butyl ether, 4,4-bisphenol, humic acid, and the organic constituents of a biologically treated coking-plant effluent have demonstrated the effectiveness of this capacity-indicator-based method of carbon selection.« less
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López, T A; Cid, M S; Bianchini, M L
1999-06-01
The literature on Conium maculatum biochemistry and toxicology, dispersed in a large number of scientific publications, has been put together in this review. C. maculatum is a weed known almost worldwide by its toxicity to many domestic animals and to human beings. It is an Umbelliferae, characterized by long, hollow stems, reaching up to 2 m height at maturity, producing a large amount of lush foliage during its vegetative growth. Its flowers are white, grouped in umbels formed by numerous umbellules. It produces a large number of seeds that allow the plant to form thick stands in modified soils, sometimes encroaching on cultivated fields, to the extent of impeding the growth of any other vegetation inside the C. maculatum area of growth. Eight piperidinic alkaloids have been identified in this species. Two of them, gamma-coniceine and coniine are generally the most abundant and they account for most of the plant acute and chronic toxicity. These alkaloids are synthesized by the plant from eight acetate units from the metabolic pool, forming a polyketoacid which cyclises through an aminotransferase and forms gamma-coniceine as the parent alkaloid via reduction by a NADPH-dependent reductase. The acute toxicity is observed when animals ingest C. maculatum vegetative and flowering plants and seeds. In a short time the alkaloids produce a neuromuscular blockage conducive to death when the respiratory muscles are affected. The chronic toxicity affects only pregnant animals. When they are poisoned by C. maculatum during the fetuses organ formation period, the offspring is born with malformations, mainly palatoschisis and multiple congenital contractures (MCC; frequently described as arthrogryposis). Acute toxicity, if not lethal, may resolve in the spontaneous recovery of the affected animals provided further exposure to C. maculatum is avoided. It has been observed that poisoned animals tend to return to feed on this plant. Chronic toxicity is irreversible and although MCC can be surgically corrected in some cases, most of the malformed animals are lost. Since no specific antidote is available, prevention is the only way to deal with the production loses caused by this weed. Control with herbicides and grazing with less susceptible animals (such as sheep) have been suggested. C. maculatum alkaloids can be transferred to milk and to fowl muscle tissue through which the former can reach the human food chain. The losses produced by C. maculatum chronic toxicity may be largely underestimated, at least in some regions, because of the difficulty in associate malformations in offspring with the much earlier maternal poisoning.
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NASA Astrophysics Data System (ADS)
Blois, Gianluca; Kim, Taehoon; Bristow, Nathan; Day, Mackenzie; Kocurek, Gary; Anderson, William; Christensen, Kenneth
2017-11-01
Impact craters, common large-scale topographic features on the surface of Mars, are circular depressions delimited by a sharp ridge. A variety of crater fill morphologies exist, suggesting that complex intracrater circulations affect their evolution. Some large craters (diameter >10 km), particularly at mid latitudes on Mars, exhibit a central mound surrounded by circular moat. Foremost among these examples is Gale crater, landing site of NASA's Curiosity rover, since large-scale climatic processes early in in the history of Mars are preserved in the stratigraphic record of the inner mound. Investigating the intracrater flow produced by large scale winds aloft Mars craters is key to a number of important scientific issues including ongoing research on Mars paleo-environmental reconstruction and the planning of future missions (these results must be viewed in conjunction with the affects of radial katabatibc flows, the importance of which is already established in preceding studies). In this work we consider a number of crater shapes inspired by Gale morphology, including idealized craters. Access to the flow field within such geometrically complex topography is achieved herein using a refractive index matched approach. Instantaneous velocity maps, using both planar and volumetric PIV techniques, are presented to elucidate complex three-dimensional flow within the crater. In addition, first- and second-order statistics will be discussed in the context of wind-driven (aeolian) excavation of crater fill.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Zarnoch, Stanley J.; Vukovich, Mark A.; Kilgo, John C.
A 14-year study of snag characteristics was established in 41- to 44-year old loblolly pine (Pinus taeda L.) stands in southeastern USA. During the initial 5.5 years, no stand manipulation or unusually high-mortality events occurred. Afterwards, three treatments were applied consisting of trees thinned and removed, trees felled and not removed, and artificial creation of snags produced by girdling and herbicide injection. The thinned treatments were designed to maintain the same live canopy density as the snag-created treatment, disregarding snags that remained standing.We monitored snag height, diameter, density, volume, and bark percentage; the number of cavities was monitored in naturalmore » snags only. During the first 5.5 years, recruitment and loss rates were stable, resulting in a stable snag population. Large snags (≥25 cm diameter) were common, but subcanopy small snags (10 to <25 cm diameter) dominated numerically. Large natural snags survived (90% quantile) significantly longer (6.0–9.4 years) than smaller snags (4.4–6.9 years). Large artificial snags persisted the longest (11.8 years). Cavities in natural snags developed within 3 years following tree death. The mean number of cavities per snag was five times greater in large versus small snags and large snags were more likely to have multiple cavities, emphasizing the importance of mature pine stands for cavity-dependent wildlife species.« less
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The effect of environmental harshness on neurogenesis: a large-scale comparison.
Chancellor, Leia V; Roth, Timothy C; LaDage, Lara D; Pravosudov, Vladimir V
2011-03-01
Harsh environmental conditions may produce strong selection pressure on traits, such as memory, that may enhance fitness. Enhanced memory may be crucial for survival in animals that use memory to find food and, thus, particularly important in environments where food sources may be unpredictable. For example, animals that cache and later retrieve their food may exhibit enhanced spatial memory in harsh environments compared with those in mild environments. One way that selection may enhance memory is via the hippocampus, a brain region involved in spatial memory. In a previous study, we established a positive relationship between environmental severity and hippocampal morphology in food-caching black-capped chickadees (Poecile atricapillus). Here, we expanded upon this previous work to investigate the relationship between environmental harshness and neurogenesis, a process that may support hippocampal cytoarchitecture. We report a significant and positive relationship between the degree of environmental harshness across several populations over a large geographic area and (1) the total number of immature hippocampal neurons, (2) the number of immature neurons relative to the hippocampal volume, and (3) the number of immature neurons relative to the total number of hippocampal neurons. Our results suggest that hippocampal neurogenesis may play an important role in environments where increased reliance on memory for cache recovery is critical. Copyright © 2010 Wiley Periodicals, Inc.
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Attack risk for butterflies changes with eyespot number and size
Ho, Sebastian; Schachat, Sandra R.; Piel, William H.; Monteiro, Antónia
2016-01-01
Butterfly eyespots are known to function in predator deflection and predator intimidation, but it is still unclear what factors cause eyespots to serve one function over the other. Both functions have been demonstrated in different species that varied in eyespot size, eyespot number and wing size, leaving the contribution of each of these factors to butterfly survival unclear. Here, we study how each of these factors contributes to eyespot function by using paper butterfly models, where each factor is varied in turn, and exposing these models to predation in the field. We find that the presence of multiple, small eyespots results in high predation, whereas single large eyespots (larger than 6 mm in diameter) results in low predation. These data indicate that single large eyespots intimidate predators, whereas multiple small eyespots produce a conspicuous, but non-intimidating signal to predators. We propose that eyespots may gain an intimidation function by increasing in size. Our measurements of eyespot size in 255 nymphalid butterfly species show that large eyespots are relatively rare and occur predominantly on ventral wing surfaces. By mapping eyespot size on the phylogeny of the family Nymphalidae, we show that these large eyespots, with a potential intimidation function, are dispersed throughout multiple nymphalid lineages, indicating that phylogeny is not a strong predictor of eyespot size. PMID:26909190
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Experimental observation of a large low-frequency band gap in a polymer waveguide
NASA Astrophysics Data System (ADS)
Miniaci, Marco; Mazzotti, Matteo; Radzieński, Maciej; Kherraz, Nesrine; Kudela, Pawel; Ostachowicz, Wieslaw; Morvan, Bruno; Bosia, Federico; Pugno, Nicola M.
2018-02-01
The quest for large and low frequency band gaps is one of the principal objectives pursued in a number of engineering applications, ranging from noise absorption to vibration control, to seismic wave abatement. For this purpose, a plethora of complex architectures (including multi-phase materials) and multi-physics approaches have been proposed in the past, often involving difficulties in their practical realization. To address this issue, in this work we propose an easy-to-manufacture design able to open large, low frequency complete Lamb band gaps exploiting a suitable arrangement of masses and stiffnesses produced by cavities in a monolithic material. The performance of the designed structure is evaluated by numerical simulations and confirmed by Scanning Laser Doppler Vibrometer (SLDV) measurements on an isotropic polyvinyl chloride plate in which a square ring region of cross-like cavities is fabricated. The full wave field reconstruction clearly confirms the ability of even a limited number of unit cell rows of the proposed design to efficiently attenuate Lamb waves. In addition, numerical simulations show that the structure allows to shift of the central frequency of the BG through geometrical modifications. The design may be of interest for applications in which large BGs at low frequencies are required.
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Dibó, Gábor
2012-02-01
Combinatorial chemistry was introduced in the 1980s. It provided the possibility to produce new compounds in practically unlimited number. New strategies and technologies have also been developed that made it possible to screen very large number of compounds and to identify useful components in mixtures containing millions of different substances. This dramatically changed the drug discovery process and the way of thinking of synthetic chemists. In addition, combinatorial strategies became useful in areas such as pharmaceutical research, agrochemistry, catalyst design, and materials research. Prof. Árpád Furka is one of the pioneers of combinatorial chemistry.
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Use of NOAA-N satellites for land/water discrimination and flood monitoring
NASA Technical Reports Server (NTRS)
Tappan, G.; Horvath, N. C.; Doraiswamy, P. C.; Engman, T.; Goss, D. W. (Principal Investigator)
1983-01-01
A tool for monitoring the extent of major floods was developed using data collected by the NOAA-6 advanced very high resolution radiometer (AVHRR). A basic understanding of the spectral returns in AVHRR channels 1 and 2 for water, soil, and vegetation was reached using a large number of NOAA-6 scenes from different seasons and geographic locations. A look-up table classifier was developed based on analysis of the reflective channel relationships for each surface feature. The classifier automatically separated land from water and produced classification maps which were registered for a number of acquisitions, including coverage of a major flood on the Parana River of Argentina.
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Bursting star formation and the overabundance of Wolf-Rayet stars
NASA Technical Reports Server (NTRS)
Bodigfee, G.; Deloore, C.
1985-01-01
The ratio of the number of WR-stars to their OB progenitors appears to be significantly higher in some extragalactic systems than in our Galaxy. This overabundance of Wolf-Rayet-stars can be explained as a consequence of a recent burst of star formation. It is suggested that this burst is the manifestation of a long period nonlinear oscillation in the star formation process, produced by positive feedback effects between young stars and the interstellar medium. Star burst galaxies with large numbers of WR-stars must generate gamma - fluxes but due to the distance, all of them are beyond the reach of present-day ray detectors, except probably 30 Dor.
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Li, Y; Akimoto, S
2017-07-01
Frequency-dependent selection is a fundamental principle of adaptive sex ratio evolution in all sex ratio theories but has rarely been detected in the wild. Through long-term censuses, we confirmed large fluctuations in the population sex ratio of the aphid Prociphilus oriens and detected frequency-dependent selection acting on these fluctuations. Fluctuations in the population sex ratio were partly attributable to climatic factors during the growing season. Climatic factors likely affected the growth conditions of host plants, which in turn led to yearly fluctuations in maternal conditions and sex ratios. In the process of frequency-dependent selection, female proportion higher or lower than ca. 60% was associated with a reduction or increase in female proportion, respectively, the next year. The rearing of aphid clones in the laboratory indicated that mothers of each clone produced an increasing number of females as maternal size increased. However, the mean male number was not related to maternal size, but varied largely among clones. Given genetic variance in the ability to produce males among clones, selection should favour clones that can produce more numerous males in years with a high female proportion. Population-level sex allocation to females was on average 71%-73% for three localities and more female-biased when maternal conditions were better. This tendency was accounted for by the hypothesis of competition among foundresses rather than the hypothesis of local mate competition. We conclude that despite consistent operation of frequency-dependent selection, the sex ratio continues to fluctuate because environmental conditions always push it away from equilibrium. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.
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Effects of the type III secreted pseudomonal toxin ExoS in the yeast Saccharomyces cerevisiae.
Stirling, Fiona R; Evans, Tom J
2006-08-01
Pseudomonas aeruginosa secretes a number of toxins by a type III system, and these are important in virulence. One of them, ExoS, is a bifunctional toxin, with a GTPase-activating protein domain, as well as ADP ribosyltransferase (ADPRT) activity. These two domains have numerous potential cellular targets, but the overall mechanism of ExoS action remains unclear. The effects of ExoS in a simple eukaryotic system, the yeast Saccharomyces cerevisiae, using a tetracycline-regulated expression system were studied. This system allowed controlled expression of ExoS in yeast, which was not possible using a galactose-induced system. ExoS was found to be an extremely potent inhibitor of yeast growth, and to be largely dependent on the activity of its ADPRT domain. ExoS produced a dramatic alteration in actin distribution, with the appearance of large aggregates of cortical actin, and thickened disorganized cables, entirely dependent on the ADPRT domain. This phenotype is suggestive of actin stabilization, which was verified by showing that the cortical aggregates of actin induced by ExoS were resistant to treatment with latrunculin A, an agent that prevents actin polymerization. ExoS increased the numbers of mating projections produced following growth arrest with mating pheromone, and prevented subsequent DNA replication, an effect that is again dependent on the ADPRT domain. Following pheromone removal, ExoS produced altered development of the mating projections, which became elongated with a swollen bud-like tip. These results suggest alternative pathways for ExoS action in eukaryotic cells that may result from activation of small GTPases, and this yeast expression system is well suited to explore these pathways.
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LiveBench-1: continuous benchmarking of protein structure prediction servers.
Bujnicki, J M; Elofsson, A; Fischer, D; Rychlewski, L
2001-02-01
We present a novel, continuous approach aimed at the large-scale assessment of the performance of available fold-recognition servers. Six popular servers were investigated: PDB-Blast, FFAS, T98-lib, GenTHREADER, 3D-PSSM, and INBGU. The assessment was conducted using as prediction targets a large number of selected protein structures released from October 1999 to April 2000. A target was selected if its sequence showed no significant similarity to any of the proteins previously available in the structural database. Overall, the servers were able to produce structurally similar models for one-half of the targets, but significantly accurate sequence-structure alignments were produced for only one-third of the targets. We further classified the targets into two sets: easy and hard. We found that all servers were able to find the correct answer for the vast majority of the easy targets if a structurally similar fold was present in the server's fold libraries. However, among the hard targets--where standard methods such as PSI-BLAST fail--the most sensitive fold-recognition servers were able to produce similar models for only 40% of the cases, half of which had a significantly accurate sequence-structure alignment. Among the hard targets, the presence of updated libraries appeared to be less critical for the ranking. An "ideally combined consensus" prediction, where the results of all servers are considered, would increase the percentage of correct assignments by 50%. Each server had a number of cases with a correct assignment, where the assignments of all the other servers were wrong. This emphasizes the benefits of considering more than one server in difficult prediction tasks. The LiveBench program (http://BioInfo.PL/LiveBench) is being continued, and all interested developers are cordially invited to join.
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Role of Brazilian zoos in ex situ bird conservation: from 1981 to 2005.
Azevedo, Cristiano S; Young, Robert J; Rodrigues, Marcos
2011-01-01
Zoos may play an important role in conservation when they maintain and breed large numbers of animals that are threatened with extinction. Bird conservation is in a privileged situation owing to the extensive biological information available about this class. Annual inventories produced by the "Sociedade de Zoológicos do Brasil" in the years 1981, 1990, 2000, and 2005 were analyzed. Variables, such as the number of zoos per geographic region; number of birds held; number of bird species in each IUCN threat category; number of exotic and native bird species; number of potentially breeding bird species; number of bird species in each order; and number of threatened bird species breeding, were analyzed. Brazilian zoos kept more than 350 bird species. The number of bird species and specimens held by the Brazilian Zoos increased from 1981 to 2000, but decreased in 2005. The same pattern was observed for the number of species in each IUCN threat category. Results showed that the potential of the Brazilian zoos in bird conservation needs to be enhanced because they maintain threatened species but do not implement systematic genetic, reproductive, or behavioral management protocols for most species. © 2010 Wiley Periodicals, Inc.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Neuffer, David; Snopok, Pavel; Alexahin, Yuri
A neutrino factory or muon collider requires the capture and cooling of a large number of muons. Scenarios for capture, bunching, phase-energy rotation and initial cooling of μ’s produced from a proton source target have been developed, initially for neutrino factory scenarios. They require a drift section from the target, a bunching section and a Φ-δE rotation section leading into the cooling channel. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport. The currently preferred cooling channel design is an “HFOFO Snake” configuration that cools both μ + and μ - transversely andmore » longitudinally. Finally, the status of the design is presented and variations are discussed.« less
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Front End for a neutrino factory or muon collider
NASA Astrophysics Data System (ADS)
Neuffer, D.; Snopok, P.; Alexahin, Y.
2017-11-01
A neutrino factory or muon collider requires the capture and cooling of a large number of muons. Scenarios for capture, bunching, phase-energy rotation and initial cooling of μ 's produced from a proton source target have been developed, initially for neutrino factory scenarios. They require a drift section from the target, a bunching section and a varphi -δ E rotation section leading into the cooling channel. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport. The currently preferred cooling channel design is an "HFOFO Snake" configuration that cools both μ+ and μ- transversely and longitudinally. The status of the design is presented and variations are discussed.
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Two phase sampling for wheat acreage estimation. [large area crop inventory experiment
NASA Technical Reports Server (NTRS)
Thomas, R. W.; Hay, C. M.
1977-01-01
A two phase LANDSAT-based sample allocation and wheat proportion estimation method was developed. This technique employs manual, LANDSAT full frame-based wheat or cultivated land proportion estimates from a large number of segments comprising a first sample phase to optimally allocate a smaller phase two sample of computer or manually processed segments. Application to the Kansas Southwest CRD for 1974 produced a wheat acreage estimate for that CRD within 2.42 percent of the USDA SRS-based estimate using a lower CRD inventory budget than for a simulated reference LACIE system. Factor of 2 or greater cost or precision improvements relative to the reference system were obtained.
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A conceptual design of shock-eliminating clover combustor for large scale scramjet engine
NASA Astrophysics Data System (ADS)
Sun, Ming-bo; Zhao, Yu-xin; Zhao, Guo-yan; Liu, Yuan
2017-01-01
A new concept of shock-eliminating clover combustor is proposed for large scale scramjet engine to fulfill the requirements of fuel penetration, total pressure recovery and cooling. To generate the circular-to-clover transition shape of the combustor, the streamline tracing technique is used based on an axisymmetric expansion parent flowfield calculated using the method of characteristics. The combustor is examined using inviscid and viscous numerical simulations and a pure circular shape is calculated for comparison. The results showed that the combustor avoids the shock wave generation and produces low total pressure losses in a wide range of flight condition with various Mach number. The flameholding device for this combustor is briefly discussed.
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The effect of clulstering of galaxies on the statistics of gravitational lenses
NASA Technical Reports Server (NTRS)
Anderson, N.; Alcock, C.
1986-01-01
It is examined whether clustering of galaxies can significantly alter the statistical properties of gravitational lenses? Only models of clustering that resemble the observed distribution of galaxies in the properties of the two-point correlation function are considered. Monte-Carlo simulations of the imaging process are described. It is found that the effect of clustering is too small to be significant, unless the mass of the deflectors is so large that gravitational lenses become common occurrences. A special model is described which was concocted to optimize the effect of clustering on gravitational lensing but still resemble the observed distribution of galaxies; even this simulation did not satisfactorily produce large numbers of wide-angle lenses.
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CNV-seq, a new method to detect copy number variation using high-throughput sequencing.
Xie, Chao; Tammi, Martti T
2009-03-06
DNA copy number variation (CNV) has been recognized as an important source of genetic variation. Array comparative genomic hybridization (aCGH) is commonly used for CNV detection, but the microarray platform has a number of inherent limitations. Here, we describe a method to detect copy number variation using shotgun sequencing, CNV-seq. The method is based on a robust statistical model that describes the complete analysis procedure and allows the computation of essential confidence values for detection of CNV. Our results show that the number of reads, not the length of the reads is the key factor determining the resolution of detection. This favors the next-generation sequencing methods that rapidly produce large amount of short reads. Simulation of various sequencing methods with coverage between 0.1x to 8x show overall specificity between 91.7 - 99.9%, and sensitivity between 72.2 - 96.5%. We also show the results for assessment of CNV between two individual human genomes.
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Knibbs, Luke D.; Kidd, Timothy J.; Wainwright, Claire E.; Wood, Michelle E.; Ramsay, Kay A.; Bell, Scott C.; Morawska, Lidia
2016-01-01
This work aimed to develop an in vivo approach for measuring the duration of human bioaerosol infectivity. To achieve this, techniques designed to target short-term and long-term bioaerosol aging, were combined in a tandem system and optimized for the collection of human respiratory bioaerosols, without contamination. To demonstrate the technique, cough aerosols were sampled from two persons with cystic fibrosis and chronic Pseudomonas aeruginosa infection. Measurements and cultures from aerosol ages of 10, 20, 40, 900 and 2700 seconds were used to determine the optimum droplet nucleus size for pathogen transport and the airborne bacterial biological decay. The droplet nuclei containing the greatest number of colony forming bacteria per unit volume of airborne sputum were between 1.5 and 2.6 μm. Larger nuclei of 3.9 μm, were more likely to produce a colony when impacted onto growth media, because the greater volume of sputum comprising the larger droplet nuclei, compensated for lower concentrations of bacteria within the sputum of larger nuclei. Although more likely to produce a colony, the larger droplet nuclei were small in number, and the greatest numbers of colonies were instead produced by nuclei from 1.5 to 5.7 μm. Very few colonies were produced by smaller droplet nuclei, despite their very large numbers. The concentration of viable bacteria within the dried sputum comprising the droplet nuclei exhibited an orderly dual decay over time with two distinct half-lives. Nuclei exhibiting a rapid biological decay process with a 10 second half-life were quickly exhausted, leaving only a subset characterized by a half-life of greater than 10 minutes. This finding implied that a subset of bacteria present in the aerosol was resistant to rapid biological decay and remained viable in room air long enough to represent an airborne infection risk. PMID:27388489
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Forming artificial soils from waste materials for mine site rehabilitation
NASA Astrophysics Data System (ADS)
Yellishetty, Mohan; Wong, Vanessa; Taylor, Michael; Li, Johnson
2014-05-01
Surface mining activities often produce large volumes of solid wastes which invariably requires the removal of significant quantities of waste rock (overburden). As mines expand, larger volumes of waste rock need to be moved which also require extensive areas for their safe disposal and containment. The erosion of these dumps may result in landform instability, which in turn may result in exposure of contaminants such as trace metals, elevated sediment delivery in adjacent waterways, and the subsequent degradation of downstream water quality. The management of solid waste materials from industrial operations is also a key component for a sustainable economy. For example, in addition to overburden, coal mines produce large amounts of waste in the form of fly ash while sewage treatment plants require disposal of large amounts of compost. Similarly, paper mills produce large volumes of alkaline rejected wood chip waste which is usually disposed of in landfill. These materials, therefore, presents a challenge in their use, and re-use in the rehabilitation of mine sites and provides a number of opportunities for innovative waste disposal. The combination of solid wastes sourced from mines, which are frequently nutrient poor and acidic, with nutrient-rich composted material produced from sewage treatment and alkaline wood chip waste has the potential to lead to a soil suitable for mine rehabilitation and successful seed germination and plant growth. This paper presents findings from two pilot projects which investigated the potential of artificial soils to support plant growth for mine site rehabilitation. We found that pH increased in all the artificial soil mixtures and were able to support plant establishment. Plant growth was greatest in those soils with the greatest proportion of compost due to the higher nutrient content. These pot trials suggest that the use of different waste streams to form an artificial soil can potentially be used in mine site rehabilitation where there is a nutrient-rich source of waste.
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Deguchi, K; Hall, P
2017-03-13
The present work is based on our recent discovery of a new class of exact coherent structures generated near the edge of quite general boundary layer flows. The structures are referred to as free-stream coherent structures and were found using a large Reynolds number asymptotic approach to describe equilibrium solutions of the Navier-Stokes equations. In this paper, first we present results for a new family of free-stream coherent structures existing at relatively large wavenumbers. The new results are consistent with our earlier theoretical result that such structures can generate larger amplitude wall streaks if and only if the local spanwise wavenumber is sufficiently small. In a Blasius boundary layer, the local wavenumber increases in the streamwise direction so the wall streaks can typically exist only over a finite interval. However, here it is shown that they can interact with wall curvature to produce exponentially growing Görtler vortices through the receptivity process by a novel nonparallel mechanism. The theoretical predictions found are confirmed by a hybrid numerical approach. In contrast with previous receptivity investigations, it is shown that the amplitude of the induced vortex is larger than the structures in the free-stream which generate it.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).
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Hladik, Michelle; Focazio, Michael J.; Engle, Mark
2014-01-01
Fluids co-produced with oil and gas production (produced waters) are often brines that contain elevated concentrations of bromide. Bromide is an important precursor of several toxic disinfection by-products (DBPs) and the treatment of produced water may lead to more brominated DBPs. To determine if wastewater treatment plants that accept produced waters discharge greater amounts of brominated DBPs, water samples were collected in Pennsylvania from four sites along a large river including an upstream site, a site below a publicly owned wastewater treatment plant (POTW) outfall (does not accept produced water), a site below an oil and gas commercial wastewater treatment plant (CWT) outfall, and downstream of the POTW and CWT. Of 29 DBPs analyzed, the site at the POTW outfall had the highest number detected (six) ranging in concentration from 0.01 to 0.09 μg L− 1 with a similar mixture of DBPs that have been detected at POTW outfalls elsewhere in the United States. The DBP profile at the CWT outfall was much different, although only two DBPs, dibromochloronitromethane (DBCNM) and chloroform, were detected, DBCNM was found at relatively high concentrations (up to 8.5 μg L− 1). The water at the CWT outfall also had a mixture of inorganic and organic precursors including elevated concentrations of bromide (75 mg L− 1) and other organic DBP precursors (phenol at 15 μg L− 1). To corroborate these DBP results, samples were collected in Pennsylvania from additional POTW and CWT outfalls that accept produced waters. The additional CWT also had high concentrations of DBCNM (3.1 μg L− 1) while the POTWs that accept produced waters had elevated numbers (up to 15) and concentrations of DBPs, especially brominated and iodinated THMs (up to 12 μg L− 1 total THM concentration). Therefore, produced water brines that have been disinfected are potential sources of DBPs along with DBP precursors to streams wherever these wastewaters are discharged.
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Akapirat, Siriwat; Avihingsanon, Anchalee; Ananworanich, Jintanat; Schuetz, Alexandra; Ramasoota, Pongrama; Luplertlop, Natthanej; Ono, Ken-Ichiro; Ikuta, Kazuyoshi; Utachee, Piraporn; Kameoka, Masanori; Leaungwutiwong, Pornsawan
2013-09-01
We conducted this study to determine the clinical variables associated with the production of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 01_AE neutralizing human monoclonal antibodies (NhMAbs) using a hybridoma technique. This cross sectional study was performed in 20 asymptomatic HIV-1-infected Thais. Peripheral blood mononuclear cells (PBMCs) were obtained from each study participant and fused with SPYMEG cells. Culture supernatant collected from growing hybridomas was tested for neutralizing activity against HIV-1 CRF01_AE Env-recombinant viruses. Fifty hybridomas expressing anti-HIV-1 NhMAbs with strong neutralizing activity against at least 1 CRF01_AE Env-recombinant virus were found. A positive association between the numbers of hybridomas produced and the CD4 counts of study participants (p = 0.019) was observed. NhMAb-producing hybridomas with strong neutralizing activity were mostly found in participans diagnosed with HIV-1 infection within the previous 1 year. The HIV-1 viral load was not significantly correlated with the numbers of either established hybridomas or clones expressing anti-HIV-1 NhMAbs with strong neutralizing activity. To our knowledge, this is the first study of NhMAb-producing hybridomas obtained from HIV-1 CRF01_AE-infected populations identified by antibody binding to HIV-1 V3 loop peptide enzyme-linked immunosorbent assay (ELISA) or TRUGENE HIV-1 Genotyping Assay (HIV-1 pol sequence). It provides important criterion to slect study participants with high CD4 counts who produce large numbers of hybridoma clones. The results are valuable for further studies related to nurtalizing antibodies production and HIV-1 vaccine development.
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The production of transuranium elements by the r-process nucleosynthesis
NASA Astrophysics Data System (ADS)
Goriely, S.; Martínez Pinedo, G.
2015-12-01
The production of super-heavy transuranium elements by stellar nucleosynthesis processes remains an open question. The most promising process that could potentially give rise to the formation of such elements is the so-called rapid neutron-capture process, or r-process, known to be at the origin of approximately half of the A > 60 stable nuclei observed in nature. However, despite important efforts, the astrophysical site of the r-process remains unidentified. Here, we study the r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars. Neutron star mergers could potentially be the dominant r-process site in the Galaxy, but also due to the extreme neutron richness found in such environment, could potentially synthesise super-heavy elements. R-process nucleosynthesis during the decompression is known to be largely insensitive to the detailed astrophysical conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. During the neutron irradiation, nuclei up to charge numbers Z ≃ 110 and mass number A ≃ 340 are produced, with a major peak production at the N = 184 shell closure, i.e. around A ≃ 280. Super-heavy nuclei with Z > 110 can hardly be produced due to the efficient fission taking place along those isotopic chains. Long-lived transuranium nuclei are inevitably produced by the r-process. The predictions concerning the production of transuranium nuclei remain however very sensitive to the predictions of fission barrier heights for such super-heavy nuclei. More nuclear predictions within different microscopic approaches are needed.
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Coal Producer's Rubber Waste Processing Development
NASA Astrophysics Data System (ADS)
Makarevich, Evgeniya; Papin, Andrey; Nevedrov, Alexander; Cherkasova, Tatyana; Ignatova, Alla
2017-11-01
A large amount of rubber-containing waste, the bulk of which are worn automobile tires and conveyor belts, is produced at coal mining and coal processing enterprises using automobile tires, conveyor belts, etc. The volume of waste generated increases every year and reaches enormous proportions. The methods for processing rubber waste can be divided into three categories: grinding, pyrolysis (high and low temperature), and decomposition by means of chemical solvents. One of the known techniques of processing the worn-out tires is their regeneration, aimed at producing the new rubber substitute used in the production of rubber goods. However, the number of worn tires used for the production of regenerate does not exceed 20% of their total quantity. The new method for processing rubber waste through the pyrolysis process is considered in this article. Experimental data on the upgrading of the carbon residue of pyrolysis by the methods of heavy media separation, magnetic and vibroseparation, and thermal processing are presented.
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NASA Astrophysics Data System (ADS)
Villet, R.
1981-02-01
The technological and economic feasibility of producing chemicals by fermentation is discussed: acetone; butanol; acetic acid; citric acid; 2,3-butanediol, and propionic acid. Improved cost of fermentative production will hinge on improving yields and using cellulosic feedstocks. The market for acetic acid is likely to grow 5 percent to 7 percent/yr. A potential process for production is the fermentation of hydrolyzed cellulosic material to ethanol followed by chemical conversion to acetic acid. The feedstock cost is 15 to 20 percent of the overall cost of production. The anticipated 5 percent growth in demand for citric acid could be enhanced by using it to displace phosphates in detergent manufacture. A number of useful chemicals can be derived from 2,3-butanediol, which has not been produced commercially on a large scale. The commercial fermentative production of propionic acid has not yet been developed.
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Ulyshen, Michael D; Mankin, Richard W; Chen, Yigen; Duan, Jian J; Poland, Therese M; Bauer, Leah S
2011-02-01
The biological control agent Tetrastichus planipennisi Yang (Hymenoptera: Eulophidae) is a gregarious larval endoparasitoid of the emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), an invasive cambium-feeding species responsible for recent, widespread mortality of ash (Fraxinus spp.) in North America. T. planipennisi is known to prefer late-instar emerald ash borer, but the cues used to assess host size by this species and most other parasitoids of concealed hosts remain unknown. We sought to test whether vibrations produced by feeding emerald ash borer vary with larval size and whether there are any correlations between these cues and T. planipennisi progeny number (i.e., brood size) and sex ratio. The amplitudes and rates of 3-30-ms vibrational impulses produced by emerald ash borer larvae of various sizes were measured in the laboratory before presenting the larvae to T. planipennisi. Impulse-rate did not vary with emerald ash borer size, but vibration amplitude was significantly higher for large larvae than for small larvae. T. planipennisi produced a significantly higher proportion of female offspring from large hosts than small hosts and was shown in previous work to produce more offspring overall from large hosts. There were no significant correlations, however, between the T. planipennisi progeny data and the emerald ash borer sound data. Because vibration amplitude varied significantly with host size, however, we are unable to entirely reject the hypothesis that T. planipennisi and possibly other parasitoids of concealed hosts use vibrational cues to assess host quality, particularly given the low explanatory potential of other external cues. Internal chemical cues also may be important.
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FASTPM: a new scheme for fast simulations of dark matter and haloes
NASA Astrophysics Data System (ADS)
Feng, Yu; Chu, Man-Yat; Seljak, Uroš; McDonald, Patrick
2016-12-01
We introduce FASTPM, a highly scalable approximated particle mesh (PM) N-body solver, which implements the PM scheme enforcing correct linear displacement (1LPT) evolution via modified kick and drift factors. Employing a two-dimensional domain decomposing scheme, FASTPM scales extremely well with a very large number of CPUs. In contrast to Comoving-Lagrangian (COLA) approach, we do not require to split the force or track separately the 2LPT solution, reducing the code complexity and memory requirements. We compare FASTPM with different number of steps (Ns) and force resolution factor (B) against three benchmarks: halo mass function from friends-of-friends halo finder; halo and dark matter power spectrum; and cross-correlation coefficient (or stochasticity), relative to a high-resolution TREEPM simulation. We show that the modified time stepping scheme reduces the halo stochasticity when compared to COLA with the same number of steps and force resolution. While increasing Ns and B improves the transfer function and cross-correlation coefficient, for many applications FASTPM achieves sufficient accuracy at low Ns and B. For example, Ns = 10 and B = 2 simulation provides a substantial saving (a factor of 10) of computing time relative to Ns = 40, B = 3 simulation, yet the halo benchmarks are very similar at z = 0. We find that for abundance matched haloes the stochasticity remains low even for Ns = 5. FASTPM compares well against less expensive schemes, being only 7 (4) times more expensive than 2LPT initial condition generator for Ns = 10 (Ns = 5). Some of the applications where FASTPM can be useful are generating a large number of mocks, producing non-linear statistics where one varies a large number of nuisance or cosmological parameters, or serving as part of an initial conditions solver.
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Don't Cry over Spilled Water: Identifying Risks and Solutions for Produced Water Spills
NASA Astrophysics Data System (ADS)
Shores, Amanda Rose
Resource requirements and future energy generation requires careful evaluation, particularly due to climate change and water scarcity. This thesis discusses one aspect of energy generation linked to water; oil-and-gas extraction and the large volumes of waste water produced, otherwise known as "produced water". This research focuses on surface spills of produced water, their ramifications, safeguards against groundwater contamination at spill sites and potential remediation strategies. Produced water contains a variety of contaminants that include the group of known toxins, BTEX (benzene, toluene, ethylbenzene and xylene), and high salt concentrations. A combination of factors such as large volumes of generated produced water, the need for storage and transportation across large distances and the toxic-and-mobile nature of produced water constituents creates risks for spills that can pollute groundwater. Spills occur regularly, particularly in Weld County, Colorado, where the demand for natural gas is high. To answer spill-related hypotheses, a multitude of methodology were employed: modeling, greenhouse experimentation, gas chromatography and summarization of spill reports and statistical analyses. Using publically available spill data, this research found that the frequency of oil-and-gas related spills and the average spilled volume has increased in Weld County from 2011-2015. Additionally, the number of spills that have resulted in groundwater contamination has increased in the area. By focusing on the oil-and-gas operators responsible for these spills, a linear relationship was found between the volumes of oil-and-gas produced compared to the volumes of produced-water generated. However, larger oil-and-gas producers did not show a linear relationship between oil-and-gas produced and produced-water generated, such that larger producers were more efficient and generated less water per unit of energy. So while scale-up efficiency seems to exist for produced-water generation, no mitigation of spill volume would be obtained by utilizing larger producers. Regardless of which operator was responsible for the spill, the groundwater depth at a spill site significantly predicted when a spill would result in groundwater contamination. This result was also validated though modeling; shallow depths to groundwater as well as larger spill volumes and coarse soil textures contributed to higher concentrations of groundwater contamination. Previous research has shown that a large fraction of spills occur at well pads. Our results suggest that fracking-site selection should preclude areas where the groundwater is shallow and soil is coarsely textured. Additionally, precautions should be taken to reduce the volume of spilled produced water to reduce the risk of groundwater contamination. This research additionally sought to reduce contaminant migration in soils towards groundwater at produced-water spill sites. In a greenhouse study it was shown that foxtail barley (Hordeum jubatum) and perennial ryegrass (Lolium perenne), can tolerate high salt concentrations in produced water while taking up minute levels of BTEX. The presence of plants changed the concentration of BTEX and naphthalene in the soil, but the direction of the change depended upon the particular plant and varied across contaminants. Additionally, the roots of either species saw no decrease of biomass upon exposure to BTEX and salt but shoots biomass was significantly reduced for foxtail barley. These results suggest that these grasses would not be capable of addressing large concentrations of BTEX at spill sites; however, these plants would be useful near well pads that regularly experience smaller spills, thus being able to tolerate spills while continually removing small amounts of BTEX in the soil. In conclusion, this thesis sought to identify holistic tools for produced-water spill prevention, mitigation and remediation to lessen environmental and health concerns while creating minimal disturbance to the natural landscape. The results lend themselves to important management information applicable to Weld County, CO but with lessons that others can draw upon elsewhere. This dissertation highlights areas for improved regulation and best management practices that can preemptively reduce the risk for groundwater contamination from produced water spills.
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Botelho, Anabela
2013-10-01
This study empirically evaluates whether the increasingly large numbers of private outpatient healthcare facilities (HCFs) within the European Union (EU) countries comply with the existing European waste legislation, and whether compliance with such legislation affects the fraction of healthcare waste (HCW) classified as hazardous. To that end, this study uses data collected by a large survey of more than 700 small private HCFs distributed throughout Portugal, a full member of the EU since 1986, where 50% of outpatient care is currently dominated by private operators. The collected data are then used to estimate a hurdle model, i.e. a statistical specification in which there are two processes: one is the process by which some HCFs generate zero or some positive fraction of hazardous HCW, and another is the process by which HCFs generate a specific positive fraction of hazardous HCW conditional on producing any. Taken together, the results show that although compliance with the law is far from ideal, it is the strongest factor influencing hazardous waste generation. In particular, it is found that higher compliance has a small and insignificant effect on the probability of generating (or reporting) positive amounts of hazardous waste, but it does have a large and significant effect on the fraction of hazardous waste produced, conditional on producing any, with a unit increase in the compliance rate leading to an estimated decrease in the fraction of hazardous HCW by 16.3 percentage points.
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Biclustering sparse binary genomic data.
van Uitert, Miranda; Meuleman, Wouter; Wessels, Lodewyk
2008-12-01
Genomic datasets often consist of large, binary, sparse data matrices. In such a dataset, one is often interested in finding contiguous blocks that (mostly) contain ones. This is a biclustering problem, and while many algorithms have been proposed to deal with gene expression data, only two algorithms have been proposed that specifically deal with binary matrices. None of the gene expression biclustering algorithms can handle the large number of zeros in sparse binary matrices. The two proposed binary algorithms failed to produce meaningful results. In this article, we present a new algorithm that is able to extract biclusters from sparse, binary datasets. A powerful feature is that biclusters with different numbers of rows and columns can be detected, varying from many rows to few columns and few rows to many columns. It allows the user to guide the search towards biclusters of specific dimensions. When applying our algorithm to an input matrix derived from TRANSFAC, we find transcription factors with distinctly dissimilar binding motifs, but a clear set of common targets that are significantly enriched for GO categories.
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Synthetic Vortex Generator Jets Used to Control Separation on Low-Pressure Turbine Airfoils
NASA Technical Reports Server (NTRS)
Ashpis, David E.; Volino, Ralph J.
2005-01-01
Low-pressure turbine (LPT) airfoils are subject to increasingly stronger pressure gradients as designers impose higher loading in an effort to improve efficiency and lower cost by reducing the number of airfoils in an engine. When the adverse pressure gradient on the suction side of these airfoils becomes strong enough, the boundary layer will separate. Separation bubbles, particularly those that fail to reattach, can result in a significant loss of lift and a subsequent degradation of engine efficiency. The problem is particularly relevant in aircraft engines. Airfoils optimized to produce maximum power under takeoff conditions may still experience boundary layer separation at cruise conditions because of the thinner air and lower Reynolds numbers at altitude. Component efficiency can drop significantly between takeoff and cruise conditions. The decrease is about 2 percent in large commercial transport engines, and it could be as large as 7 percent in smaller engines operating at higher altitudes. Therefore, it is very beneficial to eliminate, or at least reduce, the separation bubble.
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Direct numerical simulation of broadband trailing edge noise from a NACA 0012 airfoil
NASA Astrophysics Data System (ADS)
Mehrabadi, Mohammad; Bodony, Daniel
2016-11-01
Commercial jet-powered aircraft produce unwanted noise at takeoff and landing when they are close to near-airport communities. Modern high-bypass-ratio turbofan engines have reduced jet exhaust noise sufficiently such that noise from the main fan is now significant. In preparation for a large-eddy simulation of the NASA/GE Source Diagnostic Test Fan, we study the broadband noise due to the turbulent flow on a NACA 0012 airfoil at zero degree angle-of-attack, a chord-based Reynolds number of 408,000 and a Mach number of 0.115 using direct numerical simulation (DNS) and wall-modeled large-eddy simulation (WMLES). The flow conditions correspond to existing experimental data. We investigate the roughness-induced transition-to-turbulence and sound generation from a DNS perspective as well as examine how these two features are captured by a wall model. Comparisons between the DNS- and WMLES-predicted noise are made and provide guidance on the use of WMLES for broadband fan noise prediction. AeroAcoustics Research Consortium.
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Mammary gland tumors in irradiated and untreated guinea pigs
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hoch-Ligeti, C.; Liebelt, A.G.; Congdon, C.C.
1986-01-01
This is a report of mammary gland tumors from 62 guinea pigs. The tumors arose in the terminal ductal-lobular units as either lobular acinar carcinoma or cystadenocarcinoma or as papillary carcinomas within large ducts near the mammilla. About half the number of the males had terminal ductal-lobular carcinomas and all but 2 of the papillary duct carcinomas also arose in males. Large tumors frequently exhibited squamous, chondromatous, osseous, fatty and myoepitheliomatous types of tissues. In 2 irradiated males and 1 female the tumors metastasized. Whole-body irradiation did not produce significant changes in the number or sex distribution or in themore » morphology of mammary gland tumors in inbred or outbred guinea pigs. All females had cystic ovaries without increase in granulosa cells, 24 (66.6%) had uterine tumors and 13 (34.2%) had adrenal gland tumors; all males had atrophic testes, 5 (16.5%) had testicular and 6 (22.2%) had adrenal gland tumors.« less
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A comparison of spacecraft penetration hazards due to meteoroids and manmade earth-orbiting objects
NASA Technical Reports Server (NTRS)
Brooks, D. R.
1976-01-01
The ability of a typical double-walled spacecraft structure to protect against penetration by high-velocity incident objects is reviewed. The hazards presented by meteoroids are compared to the current and potential hazards due to manmade orbiting objects. It is shown that the nature of the meteoroid number-mass relationship makes adequate protection for large space facilities a conceptually straightforward structural problem. The present level of manmade orbiting objects (an estimated 10,000 in early 1975) does not pose an unacceptable risk to manned space operations proposed for the near future, but it does produce penetration probabilities in the range of 1-10 percent for a 100-m diameter sphere in orbit for 1,000 days. The number-size distribution of manmade objects is such that adequate protection is difficult to achieve for large permanent space facilities, to the extent that future restrictions on such facilities may result if the growth of orbiting objects continues at its historical rate.
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NASA Technical Reports Server (NTRS)
Mcdaniel, J. C., Jr.
1982-01-01
Laser induced fluorescence is an attractive nonintrusive approach for measuring molecular number density in compressible flows although this technique does not produce a signal that is directly related to the number density. Saturation and frequency detuned excitation are explored as means for minimizing the quenching effect using iodine as the molecular system because of its convenient absorption spectrum. Saturation experiments indicate that with available continuous wave laser sources of Gaussian transverse intensity distribution only partial saturation could be achieved in iodine at the pressures of interest in gas dynamics. Using a fluorescence lineshape theory, it is shown that for sufficiently large detuning of a narrow bandwidth laser from a molecular transition, the quenching can be cancelled by collisional broadening over a large range of pressures and temperatures. Experimental data obtained in a Mach 4.3 underexpanded jet of nitrogen seeded with iodine for various single mode argon laser detunings from a strong iodine transition at 5145 A are discussed.
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An outbreak of Bacillus cereus food poisoning--are caterers supervised sufficiently.
Slaten, D D; Oropeza, R I; Werner, S B
1992-01-01
Bacillus cereus is an uncommonly reported cause of foodborne illness in the United States. In May 1989, an outbreak of B. cereus gastroenteritis occurred among 140 guests who had attended a catered wedding reception in Napa, CA. Investigation established Cornish game hens served at the event as the vehicle for disease transmission (OR = 29, P = 0.0001). Although the spores of B. cereus are ubiquitous, large numbers of toxin-producing organisms (more than 10(5) per gram of food) are required for illness to occur. In the Napa outbreak, bacterial multiplication was facilitated at several points during the preparation and transportation of the food. While a licensed restaurant kitchen was used, the facilities were clearly inadequate for the event. At present, the California Health and Safety Code does not address the scope of catering operations. As caterers increase in number, there will be a growing need for governmental oversight to ensure that food production on a large scale is conducted safely. PMID:1641447
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Natural Organohalogens: A New Frontier for Medicinal Agents?
NASA Astrophysics Data System (ADS)
Gribble, Gordon W.
2004-10-01
More than 4000 naturally occurring organohalogen compounds are known. These include a relatively small number of abiogenic organohalogens from volcanoes, forest fires, geothermal processes, and meteorites, and a very large number of biogenic organohalogens produced by myriad living organisms as part of their chemical makeup that serve as hormones, pheromones, repellents, and natural pesticides. From the chemically simple methyl chloride, methyl bromide, and chloroform to the structurally complex vancomycin, pyrroindomycin, and bastadins, the diversity of these organohalogens is unsurpassed among natural products. Most natural organohalogens contain chlorine (2300) or bromine (2100), but a significant number contain iodine (120) or fluorine (30). Several hundred marine natural products contain both chlorine and bromine. The present article focuses on newly discovered biogenic organohalogens, with an emphasis on those biologically active examples from marine organisms, bacteria, terrestrial plants, and higher life forms including humans.
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Biodiversity hotspots house most undiscovered plant species.
Joppa, Lucas N; Roberts, David L; Myers, Norman; Pimm, Stuart L
2011-08-09
For most organisms, the number of described species considerably underestimates how many exist. This is itself a problem and causes secondary complications given present high rates of species extinction. Known numbers of flowering plants form the basis of biodiversity "hotspots"--places where high levels of endemism and habitat loss coincide to produce high extinction rates. How different would conservation priorities be if the catalog were complete? Approximately 15% more species of flowering plant are likely still undiscovered. They are almost certainly rare, and depending on where they live, suffer high risks of extinction from habitat loss and global climate disruption. By using a model that incorporates taxonomic effort over time, regions predicted to contain large numbers of undiscovered species are already conservation priorities. Our results leave global conservation priorities more or less intact, but suggest considerably higher levels of species imperilment than previously acknowledged.
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Pollution prevention at Air Force Plant {number{underscore}sign}4
DOE Office of Scientific and Technical Information (OSTI.GOV)
Daniels, E.D.; Brown, C.J.; Strukely, T.
1999-07-01
Air Force Plant {number{underscore}sign}4 in Fort Worth, Texas is home to Lockheed Martin Tactical Aircraft Systems (LMTAS). This multi-million square foot facility provides all of the design, fabrication, assembly, and testing capabilities necessary to produce the F-16 fighter and the center fuselage of the F-22 fighter. A large number of chemical products and processes are required to achieve the complex manufacturing goals. Since the early 1980s, a pollution prevention program has been in place at LMTAS to eliminate or minimize the use of hazardous chemicals and processes. The structure involves an interdepartmental teaming arrangement to determine satisfactory alternatives to existingmore » procedures as well as development of environmentally friendly methods for new design. Many of the successes are a result of teaming arrangements between LMTAS and the USAF.« less
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Han, L; Tanweer, A; Szaran, J; Halas, S
2002-09-01
A modified technique for the conversion of sulphates and sulphides to SO2 with the mixture of V2O5-SiO2 for sulphur isotopic analyses is described. This technique is more suitable for routine analysis of large number of samples. Modification of the reaction vessel and using manifold inlet system allows to analyse up to 24 samples every day. The modified technique assures the complete yield of SO2, consistent oxygen isotope composition of the SO2 gas and reproducibility of delta34S measurements being within 0.10 per thousand. It is observed, however, oxygen in SO2 produced from sulphides differs in delta18O with respect to that produced from sulphates.
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Microbiological Hazards of Household Toilets: Droplet Production and the Fate of Residual Organisms
Gerba, Charles P.; Wallis, Craig; Melnick, Joseph L.
1975-01-01
Large numbers of bacteria and viruses when seeded into household toilets were shown to remain in the bowl after flushing, and even continual flushing could not remove a persistent fraction. This was found to be due to the adsorption of the organisms to the porcelain surfaces of the bowl, with gradual elution occurring after each flush. Droplets produced by flushing toilets were found to harbor both bacteria and viruses which had been seeded. The detection of bacteria and viruses falling out onto surfaces in bathrooms after flushing indicated that they remain airborne long enough to settle on surface throughout the bathroom. Thus, there is a possibility that a person may acquire an infection from an aerosol produced by a toilet. PMID:169732
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Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels
NASA Astrophysics Data System (ADS)
Li, Qiang; Lin, Haishuang; Wang, Ou; Qiu, Xuefeng; Kidambi, Srivatsan; Deleyrolle, Loic P.; Reynolds, Brent A.; Lei, Yuguo
2016-08-01
There is growing interest in developing drugs that specifically target glioblastoma tumor-initiating cells (TICs). Current cell culture methods, however, cannot cost-effectively produce the large numbers of glioblastoma TICs required for drug discovery and development. In this paper we report a new method that encapsulates patient-derived primary glioblastoma TICs and grows them in 3 dimension thermoreversible hydrogels. Our method allows long-term culture (~50 days, 10 passages tested, accumulative ~>1010-fold expansion) with both high growth rate (~20-fold expansion/7 days) and high volumetric yield (~2.0 × 107 cells/ml) without the loss of stemness. The scalable method can be used to produce sufficient, affordable glioblastoma TICs for drug discovery.
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Pristine nonmare rocks and the nature of the lunar crust
NASA Technical Reports Server (NTRS)
Warren, P. H.; Wasson, J. T.
1977-01-01
It is shown that the interdisciplinary study of the nonmare lunar rocks based on trace element, major element, and isotopic data plus petrographic evidence can succeed in amassing a large suite of demonstrably pristine rocks, and that the relative numbers of these rocks are not in accord with statistics amassed on soil fragments and glasses. The term 'pristine' is taken to mean rocks with primary compositions (albeit not necessarily textures) produced by lunar endogenous igneous processes. Melt rocks and crystalline matrix breccias produced by impact processes are excluded. A petrographic synonym for pristine would be 'unremelted, monomict'. It is found that anorthositic norites and noritic anorthosites were rare as primary nonmare rocks. Mechanical mixing appears to have been the dominant petrogenetic process on the highlands.
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Halftoning method for the generation of motion stimuli
NASA Technical Reports Server (NTRS)
Mulligan, Jeffrey B.; Stone, Leland S.
1989-01-01
This paper describes a novel computer-graphic technique for the generation of a broad class of motion stimuli for vision research, which uses color table animation in conjunction with a single base image. Using this technique, contrast and temporal frequency can be varied with a negligible amount of computation, once a single-base image is produced. Since only two-bit planes are needed to display a single drifting grating, an eight-bit/pixel display can be used to generate four-component plaids, in which each component of the plaid has independently programmable contrast and temporal frequency. Because the contrast and temporal frequencies of the various components are mutually independent, a large number of two-dimensional stimulus motions can be produced from a single image file.
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Hard X-ray Emission from Galaxy Clusters Observed with INTEGRAL and Prospects for Simbol-X
NASA Astrophysics Data System (ADS)
Eckert, D.; Paltani, S.; Courvoisier, T. J.-L.
2009-05-01
Some galaxy clusters are known to contain a large population of relativistic electrons, which produce radio emission through synchrotron radiation. Therefore, it is expected that inverse-Compton scattering of the relativistic electrons with the CMB produce non-thermal emission which should be observable in the hard X-ray domain. Here we focus on the recent results by INTEGRAL, which shed a new light on the non-thermal emission thanks to its angular resolution and sensitivity in the hard X-ray range. We also present the exciting prospects in this field for Simbol-X, which will allow us to detect the non-thermal emission in a number of clusters and map the magnetic field throughout the intra-cluster medium.
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High resolution three-dimensional reconstruction of fibrotic skeletal muscle extracellular matrix.
Gillies, Allison R; Chapman, Mark A; Bushong, Eric A; Deerinck, Thomas J; Ellisman, Mark H; Lieber, Richard L
2017-02-15
Fibrosis occurs secondary to many skeletal muscle diseases and injuries, and can alter muscle function. It is unknown how collagen, the most abundant extracellular structural protein, alters its organization during fibrosis. Quantitative and qualitative high-magnification electron microscopy shows that collagen is organized into perimysial cables which increase in number in a model of fibrosis, and cables have unique interactions with collagen-producing cells. Fibrotic muscles are stiffer and have a higher concentration of collagen-producing cells. These results improve our understanding of the organization of fibrotic skeletal muscle extracellular matrix and identify novel structures that might be targeted by antifibrotic therapy. Skeletal muscle extracellular matrix (ECM) structure and organization are not well understood, yet the ECM plays an important role in normal tissue homeostasis and disease processes. Fibrosis is common to many muscle diseases and is typically quantified based on an increase in ECM collagen. Through the use of multiple imaging modalities and quantitative stereology, we describe the structure and composition of wild-type and fibrotic ECM, we show that collagen in the ECM is organized into large bundles of fibrils, or collagen cables, and the number of these cables (but not their size) increases in desmin knockout muscle (a fibrosis model). The increase in cable number is accompanied by increased muscle stiffness and an increase in the number of collagen producing cells. Unique interactions between ECM cells and collagen cables were also observed and reconstructed by serial block face scanning electron microscopy. These results demonstrate that the muscle ECM is more highly organized than previously reported. Therapeutic strategies for skeletal muscle fibrosis should consider the organization of the ECM to target the structures and cells contributing to fibrotic muscle function. © 2016 Rehabilitation Institute of Chicago. The Journal of Physiology © 2016 The Physiological Society.
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High resolution three‐dimensional reconstruction of fibrotic skeletal muscle extracellular matrix
Gillies, Allison R.; Chapman, Mark A.; Bushong, Eric A.; Deerinck, Thomas J.; Ellisman, Mark H.
2016-01-01
Key points Fibrosis occurs secondary to many skeletal muscle diseases and injuries, and can alter muscle function.It is unknown how collagen, the most abundant extracellular structural protein, alters its organization during fibrosis.Quantitative and qualitative high‐magnification electron microscopy shows that collagen is organized into perimysial cables which increase in number in a model of fibrosis, and cables have unique interactions with collagen‐producing cells.Fibrotic muscles are stiffer and have a higher concentration of collagen‐producing cells.These results improve our understanding of the organization of fibrotic skeletal muscle extracellular matrix and identify novel structures that might be targeted by antifibrotic therapy. Abstract Skeletal muscle extracellular matrix (ECM) structure and organization are not well understood, yet the ECM plays an important role in normal tissue homeostasis and disease processes. Fibrosis is common to many muscle diseases and is typically quantified based on an increase in ECM collagen. Through the use of multiple imaging modalities and quantitative stereology, we describe the structure and composition of wild‐type and fibrotic ECM, we show that collagen in the ECM is organized into large bundles of fibrils, or collagen cables, and the number of these cables (but not their size) increases in desmin knockout muscle (a fibrosis model). The increase in cable number is accompanied by increased muscle stiffness and an increase in the number of collagen producing cells. Unique interactions between ECM cells and collagen cables were also observed and reconstructed by serial block face scanning electron microscopy. These results demonstrate that the muscle ECM is more highly organized than previously reported. Therapeutic strategies for skeletal muscle fibrosis should consider the organization of the ECM to target the structures and cells contributing to fibrotic muscle function. PMID:27859324
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Lombari, P; Ercolano, E; El Alaoui, H; Chiurazzi, M
2003-04-01
We describe herein a simple and efficient transformation procedure for the production of transgenic Lotus japonicus plants. In this new procedure, dedifferentiated root explants, used as starting material, are the source of a large number of cells that are competent for the regeneration procedure, with a high susceptibility to Agrobacterium infection. The application of this protocol resulted in a tenfold increase in the number of transformants produced by a single plant in comparison to the widely used hypocotyl transformation procedure. Furthermore, our procedure allowed the use of intact plants stored for a long time at 4 degrees C, thus providing a potential continuous supply of explants for transformation experiments. The overall time of incubation under tissue culture conditions required to obtain a plant transferable into soil is 4 months. The transgenic nature of the transformants was demonstrated by the detection of beta-glucuronidase (GUS) activity in the primary transformants and by molecular analysis. Stable transformation was indicated by Mendelian segregation of the hygromycin selectable marker and of the gusA activity after selfing of the transgenic plants.
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Emerging electrochemical energy conversion and storage technologies
NASA Astrophysics Data System (ADS)
Badwal, Sukhvinder; Giddey, Sarbjit; Munnings, Christopher; Bhatt, Anand; Hollenkamp, Tony
2014-09-01
Electrochemical cells and systems play a key role in a wide range of industry sectors. These devices are critical enabling technologies for renewable energy; energy management, conservation and storage; pollution control / monitoring; and greenhouse gas reduction. A large number of electrochemical energy technologies have been developed in the past. These systems continue to be optimized in terms of cost, life time and performance, leading to their continued expansion into existing and emerging market sectors. The more established technologies such as deep-cycle batteries and sensors are being joined by emerging technologies such as fuel cells, large format lithium-ion batteries, electrochemical reactors; ion transport membranes and supercapacitors. This growing demand (multi billion dollars) for electrochemical energy systems along with the increasing maturity of a number of technologies is having a significant effect on the global research and development effort which is increasing in both in size and depth. A number of new technologies, which will have substantial impact on the environment and the way we produce and utilize energy, are under development. This paper presents an overview of several emerging electrochemical energy technologies along with a discussion some of the key technical challenges.
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Emerging electrochemical energy conversion and storage technologies
Badwal, Sukhvinder P. S.; Giddey, Sarbjit S.; Munnings, Christopher; Bhatt, Anand I.; Hollenkamp, Anthony F.
2014-01-01
Electrochemical cells and systems play a key role in a wide range of industry sectors. These devices are critical enabling technologies for renewable energy; energy management, conservation, and storage; pollution control/monitoring; and greenhouse gas reduction. A large number of electrochemical energy technologies have been developed in the past. These systems continue to be optimized in terms of cost, life time, and performance, leading to their continued expansion into existing and emerging market sectors. The more established technologies such as deep-cycle batteries and sensors are being joined by emerging technologies such as fuel cells, large format lithium-ion batteries, electrochemical reactors; ion transport membranes and supercapacitors. This growing demand (multi billion dollars) for electrochemical energy systems along with the increasing maturity of a number of technologies is having a significant effect on the global research and development effort which is increasing in both in size and depth. A number of new technologies, which will have substantial impact on the environment and the way we produce and utilize energy, are under development. This paper presents an overview of several emerging electrochemical energy technologies along with a discussion some of the key technical challenges. PMID:25309898
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sirunyan, Albert M; et al.
A search for supersymmetry is presented based on multijet events with large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of sqrt(s)=13 TeV. The data, corresponding to an integrated luminosity of 35.9 inverse femtobarns, were collected with the CMS detector at the CERN LHC in 2016. The analysis utilizes four-dimensional exclusive search regions defined in terms of the number of jets, the number of tagged bottom quark jets, the scalar sum of jet transverse momenta, and the magnitude of the vector sum of jet transverse momenta. No evidence for a significant excess of events is observed relativemore » to the expectation from the standard model. Limits on the cross sections for the pair production of gluinos and squarks are derived in the context of simplified models. Assuming the lightest supersymmetric particle to be a weakly interacting neutralino, 95% confidence level lower limits on the gluino mass as large as 1800 to 1960 GeV are derived, and on the squark mass as large as 960 to 1390 GeV, depending on the production and decay scenario.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Figueroa, Aldo; Meunier, Patrice; Villermaux, Emmanuel
2014-01-15
We present a combination of experiment, theory, and modelling on laminar mixing at large Péclet number. The flow is produced by oscillating electromagnetic forces in a thin electrolytic fluid layer, leading to oscillating dipoles, quadrupoles, octopoles, and disordered flows. The numerical simulations are based on the Diffusive Strip Method (DSM) which was recently introduced (P. Meunier and E. Villermaux, “The diffusive strip method for scalar mixing in two-dimensions,” J. Fluid Mech. 662, 134–172 (2010)) to solve the advection-diffusion problem by combining Lagrangian techniques and theoretical modelling of the diffusion. Numerical simulations obtained with the DSM are in reasonable agreement withmore » quantitative dye visualization experiments of the scalar fields. A theoretical model based on log-normal Probability Density Functions (PDFs) of stretching factors, characteristic of homogeneous turbulence in the Batchelor regime, allows to predict the PDFs of scalar in agreement with numerical and experimental results. This model also indicates that the PDFs of scalar are asymptotically close to log-normal at late stages, except for the large concentration levels which correspond to low stretching factors.« less
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Progress, pitfalls and parallel universes: a history of insect phylogenetics
Simon, Chris; Yavorskaya, Margarita; Beutel, Rolf G.
2016-01-01
The phylogeny of insects has been both extensively studied and vigorously debated for over a century. A relatively accurate deep phylogeny had been produced by 1904. It was not substantially improved in topology until recently when phylogenomics settled many long-standing controversies. Intervening advances came instead through methodological improvement. Early molecular phylogenetic studies (1985–2005), dominated by a few genes, provided datasets that were too small to resolve controversial phylogenetic problems. Adding to the lack of consensus, this period was characterized by a polarization of philosophies, with individuals belonging to either parsimony or maximum-likelihood camps; each largely ignoring the insights of the other. The result was an unfortunate detour in which the few perceived phylogenetic revolutions published by both sides of the philosophical divide were probably erroneous. The size of datasets has been growing exponentially since the mid-1980s accompanied by a wave of confidence that all relationships will soon be known. However, large datasets create new challenges, and a large number of genes does not guarantee reliable results. If history is a guide, then the quality of conclusions will be determined by an improved understanding of both molecular and morphological evolution, and not simply the number of genes analysed. PMID:27558853
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An approach to radiation safety department benchmarking in academic and medical facilities.
Harvey, Richard P
2015-02-01
Based on anecdotal evidence and networking with colleagues at other facilities, it has become evident that some radiation safety departments are not adequately staffed and radiation safety professionals need to increase their staffing levels. Discussions with management regarding radiation safety department staffing often lead to similar conclusions. Management acknowledges the Radiation Safety Officer (RSO) or Director of Radiation Safety's concern but asks the RSO to provide benchmarking and justification for additional full-time equivalents (FTEs). The RSO must determine a method to benchmark and justify additional staffing needs while struggling to maintain a safe and compliant radiation safety program. Benchmarking and justification are extremely important tools that are commonly used to demonstrate the need for increased staffing in other disciplines and are tools that can be used by radiation safety professionals. Parameters that most RSOs would expect to be positive predictors of radiation safety staff size generally are and can be emphasized in benchmarking and justification report summaries. Facilities with large radiation safety departments tend to have large numbers of authorized users, be broad-scope programs, be subject to increased controls regulations, have large clinical operations, have significant numbers of academic radiation-producing machines, and have laser safety responsibilities.
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Energy transfer in turbulence under rotation
NASA Astrophysics Data System (ADS)
Buzzicotti, Michele; Aluie, Hussein; Biferale, Luca; Linkmann, Moritz
2018-03-01
It is known that rapidly rotating turbulent flows are characterized by the emergence of simultaneous upscale and downscale energy transfer. Indeed, both numerics and experiments show the formation of large-scale anisotropic vortices together with the development of small-scale dissipative structures. However the organization of interactions leading to this complex dynamics remains unclear. Two different mechanisms are known to be able to transfer energy upscale in a turbulent flow. The first is characterized by two-dimensional interactions among triads lying on the two-dimensional, three-component (2D3C)/slow manifold, namely on the Fourier plane perpendicular to the rotation axis. The second mechanism is three-dimensional and consists of interactions between triads with the same sign of helicity (homochiral). Here, we present a detailed numerical study of rotating flows using a suite of high-Reynolds-number direct numerical simulations (DNS) within different parameter regimes to analyze both upscale and downscale cascade ranges. We find that the upscale cascade at wave numbers close to the forcing scale is generated by increasingly dominant homochiral interactions which couple the three-dimensional bulk and the 2D3C plane. This coupling produces an accumulation of energy in the 2D3C plane, which then transfers energy to smaller wave numbers thanks to the two-dimensional mechanism. In the forward cascade range, we find that the energy transfer is dominated by heterochiral triads and is dominated primarily by interaction within the fast manifold where kz≠0 . We further analyze the energy transfer in different regions in the real-space domain. In particular, we distinguish high-strain from high-vorticity regions and we uncover that while the mean transfer is produced inside regions of strain, the rare but extreme events of energy transfer occur primarily inside the large-scale column vortices.
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Can camera traps monitor Komodo dragons a large ectothermic predator?
Ariefiandy, Achmad; Purwandana, Deni; Seno, Aganto; Ciofi, Claudio; Jessop, Tim S
2013-01-01
Camera trapping has greatly enhanced population monitoring of often cryptic and low abundance apex carnivores. Effectiveness of passive infrared camera trapping, and ultimately population monitoring, relies on temperature mediated differences between the animal and its ambient environment to ensure good camera detection. In ectothermic predators such as large varanid lizards, this criterion is presumed less certain. Here we evaluated the effectiveness of camera trapping to potentially monitor the population status of the Komodo dragon (Varanus komodoensis), an apex predator, using site occupancy approaches. We compared site-specific estimates of site occupancy and detection derived using camera traps and cage traps at 181 trapping locations established across six sites on four islands within Komodo National Park, Eastern Indonesia. Detection and site occupancy at each site were estimated using eight competing models that considered site-specific variation in occupancy (ψ)and varied detection probabilities (p) according to detection method, site and survey number using a single season site occupancy modelling approach. The most parsimonious model [ψ (site), p (site survey); ω = 0.74] suggested that site occupancy estimates differed among sites. Detection probability varied as an interaction between site and survey number. Our results indicate that overall camera traps produced similar estimates of detection and site occupancy to cage traps, irrespective of being paired, or unpaired, with cage traps. Whilst one site showed some evidence detection was affected by trapping method detection was too low to produce an accurate occupancy estimate. Overall, as camera trapping is logistically more feasible it may provide, with further validation, an alternative method for evaluating long-term site occupancy patterns in Komodo dragons, and potentially other large reptiles, aiding conservation of this species.
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Can Camera Traps Monitor Komodo Dragons a Large Ectothermic Predator?
Ariefiandy, Achmad; Purwandana, Deni; Seno, Aganto; Ciofi, Claudio; Jessop, Tim S.
2013-01-01
Camera trapping has greatly enhanced population monitoring of often cryptic and low abundance apex carnivores. Effectiveness of passive infrared camera trapping, and ultimately population monitoring, relies on temperature mediated differences between the animal and its ambient environment to ensure good camera detection. In ectothermic predators such as large varanid lizards, this criterion is presumed less certain. Here we evaluated the effectiveness of camera trapping to potentially monitor the population status of the Komodo dragon (Varanus komodoensis), an apex predator, using site occupancy approaches. We compared site-specific estimates of site occupancy and detection derived using camera traps and cage traps at 181 trapping locations established across six sites on four islands within Komodo National Park, Eastern Indonesia. Detection and site occupancy at each site were estimated using eight competing models that considered site-specific variation in occupancy (ψ)and varied detection probabilities (p) according to detection method, site and survey number using a single season site occupancy modelling approach. The most parsimonious model [ψ (site), p (site*survey); ω = 0.74] suggested that site occupancy estimates differed among sites. Detection probability varied as an interaction between site and survey number. Our results indicate that overall camera traps produced similar estimates of detection and site occupancy to cage traps, irrespective of being paired, or unpaired, with cage traps. Whilst one site showed some evidence detection was affected by trapping method detection was too low to produce an accurate occupancy estimate. Overall, as camera trapping is logistically more feasible it may provide, with further validation, an alternative method for evaluating long-term site occupancy patterns in Komodo dragons, and potentially other large reptiles, aiding conservation of this species. PMID:23527027
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Machine Identification of Martian Craters Using Digital Elevation Data
NASA Astrophysics Data System (ADS)
Bue, B.; Stepinski, T. F.
2005-12-01
Impact craters are among the most studied features on Martian surface. Their importance stems from the worth of information that a detailed analysis of their number and morphology can bring forth. Because building manually a comprehensive dataset of craters is a laborious process, there have been many previous attempts to develop an automatic, image-based crater identifier. The resulting identifiers suffer from low efficiency and remain in an experimental stage. We have developed a DEM-based, fully autonomous crater identifier that takes an arbitrarily large Martian site as an input and produces a catalog of craters as an output. Using the topography data we calculate a topographic profile curvature that is thresholded to produce a binary image, pixels having maximum negative curvature are labeled black, the remaining pixels are labeled white. The black pixels outline craters because crater rims are the most convex feature in the Martian landscape. The Hough Transform (HT) is used for an actual recognition of craters in the binary image. The image is first segmented (without cutting the craters) into a large number of smaller images using the ``flood" algorithm that identifies basins. This segmentation makes possible the application of highly inefficient HT to large sites. The identifier is applied to a 106 km2 site located around the Herschel crater. According to the Barlow catalog, this site contains 485 craters >5 km. Our identifier finds 1099 segments, 628 of them are classified as craters >5 km. Overall, there is an excellent agreement between the two catalogs, although the specific statistics are still pending due to the difficulties in recalculating the MDIM 1 coordinate system used in the Barlow catalog to the MDIM 2.1 coordinate system used by our identifier.
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Genetic and environmental factors affecting cryptic variations in gene regulatory networks
2013-01-01
Background Cryptic genetic variation (CGV) is considered to facilitate phenotypic evolution by producing visible variations in response to changes in the internal and/or external environment. Several mechanisms enabling the accumulation and release of CGVs have been proposed. In this study, we focused on gene regulatory networks (GRNs) as an important mechanism for producing CGVs, and examined how interactions between GRNs and the environment influence the number of CGVs by using individual-based simulations. Results Populations of GRNs were allowed to evolve under various stabilizing selections, and we then measured the number of genetic and phenotypic variations that had arisen. Our results showed that CGVs were not depleted irrespective of the strength of the stabilizing selection for each phenotype, whereas the visible fraction of genetic variation in a population decreased with increasing strength of selection. On the other hand, increasing the number of different environments that individuals encountered within their lifetime (i.e., entailing plastic responses to multiple environments) suppressed the accumulation of CGVs, whereas the GRNs with more genes and interactions were favored in such heterogeneous environments. Conclusions Given the findings that the number of CGVs in a population was largely determined by the size (order) of GRNs, we propose that expansion of GRNs and adaptation to novel environments are mutually facilitating and sustainable sources of evolvability and hence the origins of biological diversity and complexity. PMID:23622056
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Genetic and environmental factors affecting cryptic variations in gene regulatory networks.
Iwasaki, Watal M; Tsuda, Masaki E; Kawata, Masakado
2013-04-26
Cryptic genetic variation (CGV) is considered to facilitate phenotypic evolution by producing visible variations in response to changes in the internal and/or external environment. Several mechanisms enabling the accumulation and release of CGVs have been proposed. In this study, we focused on gene regulatory networks (GRNs) as an important mechanism for producing CGVs, and examined how interactions between GRNs and the environment influence the number of CGVs by using individual-based simulations. Populations of GRNs were allowed to evolve under various stabilizing selections, and we then measured the number of genetic and phenotypic variations that had arisen. Our results showed that CGVs were not depleted irrespective of the strength of the stabilizing selection for each phenotype, whereas the visible fraction of genetic variation in a population decreased with increasing strength of selection. On the other hand, increasing the number of different environments that individuals encountered within their lifetime (i.e., entailing plastic responses to multiple environments) suppressed the accumulation of CGVs, whereas the GRNs with more genes and interactions were favored in such heterogeneous environments. Given the findings that the number of CGVs in a population was largely determined by the size (order) of GRNs, we propose that expansion of GRNs and adaptation to novel environments are mutually facilitating and sustainable sources of evolvability and hence the origins of biological diversity and complexity.
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Commissaris, R L; Lyness, W H; Rech, R H
1981-05-01
The purpose of the present study was to determine the role of central 5-hydroxytryptamine (5-HT) neuronal systems in the effects of d-lysergic acid diethylamide (LSD), 2,5-methoxy-4-methylamphetamine (DOM), pentobarbital (PB) and methaqualone (MQ) on punished responding in rats. Water-deprived rats were trained to drink from a tube that was electrified at intervals (variable interval 21 sec; 0.03 mA current intensity), electrification being signalled by a tone. In daily 10-min control sessions, these animals accepted a relatively constant number of shocks; water consumption was also quite stable. At maximally effective doses PB, and to a lesser extent MQ, produced large (400-600 percent of control) increases in punished responding with little decrease in water intake. Higher doses of these agents produced a significant depression of unpunished responding (water intake). The hallucinogens, on the other hand, produced only moderate (125-175 percent of control) increases in the number of shock received, yet a similar depression of unpunished responding. Selective destruction of 5-HT neurons by intracerebroventricular administration of the neurotoxin 5,7-dihydroxytryptamine per se produced little change in the number of shocks received or water consumed in controls sessions. This destruction of 5-HT neurons failed to alter the effects of PB or MQ on punished or unpunished responding. The increase in punished responding produced by the hallucinogens, however, was blocked by this destruction of 5-HT neurons. Furthermore, the capacity of the hallucinogens to decrease water intake was significantly potentiated by the neurotoxin pretreatment. These data demonstrate that the effects of the hallucinogens LSD and DOM on conditioned suppression are quite different from those of PB and MQ, and that this difference may be due to the extent of 5-HT involvement in the effects of these agents.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
D. SIEBE; K. PASAMEHMETOGLU
The Accelerator Production of Tritium neutron source consists of clad tungsten targets, which are concentric cylinders with a center rod. These targets are arranged in a matrix of tubes, producing a large number of parallel coolant paths. The coolant flow required to meet thermal-hydraulic design criteria varies with location. This paper describes the work performed to ensure an adequate coolant flow for each target for normal operation and residual heat-removal conditions.
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Statistical error in simulations of Poisson processes: Example of diffusion in solids
NASA Astrophysics Data System (ADS)
Nilsson, Johan O.; Leetmaa, Mikael; Vekilova, Olga Yu.; Simak, Sergei I.; Skorodumova, Natalia V.
2016-08-01
Simulations of diffusion in solids often produce poor statistics of diffusion events. We present an analytical expression for the statistical error in ion conductivity obtained in such simulations. The error expression is not restricted to any computational method in particular, but valid in the context of simulation of Poisson processes in general. This analytical error expression is verified numerically for the case of Gd-doped ceria by running a large number of kinetic Monte Carlo calculations.
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The rid-redundant procedure in C-Prolog
NASA Technical Reports Server (NTRS)
Chen, Huo-Yan; Wah, Benjamin W.
1987-01-01
C-Prolog can conveniently be used for logical inferences on knowledge bases. However, as similar to many search methods using backward chaining, a large number of redundant computation may be produced in recursive calls. To overcome this problem, the 'rid-redundant' procedure was designed to rid all redundant computations in running multi-recursive procedures. Experimental results obtained for C-Prolog on the Vax 11/780 computer show that there is an order of magnitude improvement in the running time and solvable problem size.
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How vertical integration affects the quantity and cost of care for Medicare beneficiaries.
Koch, Thomas G; Wendling, Brett W; Wilson, Nathan E
2017-03-01
Health systems are employing physicians in growing numbers. The implications of this trend are poorly understood and controversial. We use rich data from the Centers for Medicare and Medicaid Services to examine the effects of a set of physician acquisitions by hospital systems on outpatient utilization and spending. We find that financial integration systematically produces economically large changes in the acquired physicians' behavior, but has less consistent effects at the acquiring system level. Published by Elsevier B.V.
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Optically simulating a quantum associative memory
NASA Astrophysics Data System (ADS)
Howell, John C.; Yeazell, John A.; Ventura, Dan
2000-10-01
This paper discusses the realization of a quantum associative memory using linear integrated optics. An associative memory produces a full pattern of bits when presented with only a partial pattern. Quantum computers have the potential to store large numbers of patterns and hence have the ability to far surpass any classical neural-network realization of an associative memory. In this work two three-qubit associative memories will be discussed using linear integrated optics. In addition, corrupted, invented and degenerate memories are discussed.
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Heil, John R; Nordeste, Ricardo F; Charles, Trevor C
2011-04-01
Here we report a simple cost-effective device for screening colonies on plates for expression of the monomeric red fluorescent protein mRFP1 and the fluorescent dye Nile red. This device can be built from any simple light source, in our case a Quebec Colony Counter, and cost-effective theatre gels. The device can be assembled in as little as 20 min, and it produces excellent results when screening a large number of colonies.
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Controlled propulsion of artificial magnetic nanostructured propellers.
Ghosh, Ambarish; Fischer, Peer
2009-06-01
For biomedical applications, such as targeted drug delivery and microsurgery, it is essential to develop a system of swimmers that can be propelled wirelessly in fluidic environments with good control. Here, we report the construction and operation of chiral colloidal propellers that can be navigated in water with micrometer-level precision using homogeneous magnetic fields. The propellers are made via nanostructured surfaces and can be produced in large numbers. The nanopropellers can carry chemicals, push loads, and act as local probes in rheological measurements.
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2008-12-01
dollars) • produced with the research capabilities (as demonstrated by related publications) within any one of a large number of countries where it would...capabilities, investment, and related research activities from a global perspective. Emphasis is made on demonstrating that access to the actual...sequence into an automatic synthesizer. Once the rDNA, new gene, or whole novel genome has been generated and introduced into either one or a few
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NASA Astrophysics Data System (ADS)
Ma, Ernest; Restrepo, Diego; Zapata, Óscar
2018-01-01
The well-known leptonic U(1) symmetry of the Standard Model (SM) of quarks and leptons is extended to include a number of new fermions and scalars. The resulting theory has an invisible QCD axion (thereby solving the strong CP problem), a candidate for weak-scale dark matter (DM), as well as radiative neutrino masses. A possible key connection is a color-triplet scalar, which may be produced and detected at the Large Hadron Collider.
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1984-07-01
SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on rover&* side If necessary and Identify by block number) Anthropometry , Cockpit Compatibility, Aircraft...report is one of a series of reports on anthropometry in US Army Aviation produced by the US Army Aeromedical Research Laboratory (USAARL...and stick (OV-1D). 4 , 26 *w. I.. REFERENCES Churchill, E., Churchill, T., McConville, J.T., and White, R.M. 1977. Anthropometry of women of the U.S
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1985-10-30
Brook Shelters). During this long period a large number of different projectile point types were produced (ie, Rice Lobed, Big Sandy, White River Archaic...Hidden Valley Stemmed, Hardin Barbed, Sear- cy, Rice Lanceolate, Jakie Stemmed, and Johnson). No controlled excavations have been done at any Early...University of Arkansas, Fayetteville. Edrington, Mabel 1962 History of Mississippi County. Arkansas. Ocala Star Banner, Ocala, Florida. 5 68
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DNA Lesions Caused by ROS and RNOS: A Review of Interactions and Reactions Involving Guanine
NASA Astrophysics Data System (ADS)
Shukla, P. K.; Mishra, P. C.
DNA is constantly attacked by a large number of endogenous and exogenous reactive oxygen species (ROS), reactive nitrogen oxide species (RNOS), and alkylating agents which produce a wide variety of modifications of its constituents, particularly the bases. Some of these modifications (lesions) are hazardous to normal cell functioning, and are implicated in several lethal conditions including chronic inflammatory diseases, atherosclerosis, aging, mutation, cancer, and neurodegenerative disorders, such as the Alzheimer's and Parkinson's diseases.
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The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.
Adekoya, Olayiwola A; Sylte, Ingebrigt
2009-01-01
Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. M4 family comprises numerous zinc-dependent metallopeptidases that hydrolyze peptide bonds. A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Some enzymes of the family are able to function at the extremes of temperatures, and some function in organic solvents. Thereby enzymes of the thermolysin family have an innovative potential for biotechnological applications.
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Open clusters as laboratories: The angular momentum evolution of young stars
NASA Technical Reports Server (NTRS)
Stauffer, John R.
1994-01-01
This is the annual status report for the third year of our LTSA grant 'Open Clusters as Laboratories.' Because we have now had a few years to work on the project, we have started to produce and publish a large number of papers. We have been extremely successful in obtaining ROSAT observations of open clusters. With the demise of the PSPC on ROSAT, our main data source has come to an end and we will be able to concentrate on analyzing those data.
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Major International R and D Ranges and Test Facilities. Summary of Capabilities
1990-01-01
with a maximum impulse of firing of large numbers of rounds by a weapon in order to 1500 G and a maximum test item weight of 200 pounds. produce...millimetres may be fired safely, using test item weight of 1,000 pounds. training practice or training practice tracer ammunition. The :ange butts consist of...predictions of coherent sound propagation loss in the ocean. This information is useful in estimating the performance of low-frequency passive sonars
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The mute swan, its status, behavior, and history in the U. K
Lohnes, E.J.R.; Perry, Matthew C.
2004-01-01
For many years the mute swan has been considered a royal bird. It is a prominent resident throughout the United Kingdom (U.K.), often found on the inland waterways. Some people consider it to be a nonmigratory native bird because it doesn't tend to move large distances and doesn't often venture far from freshwater. A mute swan may often live out its life cycle in the same river valley in which it hatched. Over the last 30-40 years, a large amount of research has been carried out on their life cycle, behavior, and mortality caused by such factors as lead poisoning from fishing weights. Throughout the U.K., there are a number of areas where mute swans may be found in large numbers, including (1) the River Thames (which passes through London), (2) Slimbridge Wetlands Center, (3) Berwick-upon- Tweed (the second largest mute swan colony in Britain), and (4) Abbotsbury Swannery (the worlds only managed swan colony). This last site is a truly unique area, and each year it often has over 150 nesting pairs producing between 2-12 eggs per nest. The management is minimal, and the site is ideal for their requirements because it is close to a number of freshwater sources, and has good nesting sites and large quantities of eelgrass Zostera marina and widgeon grass Ruppia maritima, their preferred food sources. The Swannery is located on the south coast of England at the western end of the Fleet Lagoon, a micro-tidal estuary, which borders the English Channel.
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Influence of microgravity on ultrastructure and storage reserves in seeds of Brassica rapa L
NASA Technical Reports Server (NTRS)
Kuang, A.; Xiao, Y.; McClure, G.; Musgrave, M. E.
2000-01-01
Successful plant reproduction under spaceflight conditions has been problematic in the past. During a 122 d opportunity on the Mir space station, full life cycles of Brassica rapa L. were completed in microgravity in a series of three experiments in the Svet greenhouse. Ultrastructural and cytochemical analyses of storage reserves in mature dry seeds produced in these experiments were compared with those of seeds produced during a high-fidelity ground control. Additional analyses were performed on developing Brassica embryos, 15 d post pollination, which were produced during a separate experiment on the Shuttle (STS-87). Seeds produced on Mir had less than 20% of the cotyledon cell number found in seeds harvested from the ground control. Cytochemical localization of storage reserves in mature cotyledons showed that starch was retained in the spaceflight material, whereas protein and lipid were the primary storage reserves in ground control seeds. Protein bodies in mature cotyledons produced in space were 44% smaller than those in the ground control seeds. Fifteen days after pollination, cotyledon cells from mature embryos formed in space had large numbers of starch grains, and protein bodies were absent, while in developing ground control seeds at the same stage, protein bodies had already formed and fewer starch grains were evident. These data suggest that both the late stage of seed development and maturation are changed in Brassica by growth in a microgravity environment. While gravity is not absolutely required for any step in the plant life cycle, seed quality in Brassica is compromised by development in microgravity.
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Leung, Jonathan G; Nelson, Sarah; Cunningham, Julie L; Thompson, Virginia H; Bobo, William V; Kung, Simon; Dierkhising, Ross A; Plevak, Matthew F; Lapid, Maria I
2016-08-01
Quetiapine is an oral atypical antipsychotic drug commonly used to treat a large number of neuropsychiatric disorders and conditions. However, a substantial number of patients who may benefit from treatment with quetiapine are unable to ingest quetiapine or other medications by mouth and thus require alternative routes of administration. There are currently no studies evaluating non-oral compounded dosage forms of quetiapine. We conducted a single-dose open-label crossover pharmacokinetic study in 10 healthy adults to determine whether quetiapine compounded as a rectal suppository or a topical cream achieved absorption similar to that achieved by a commercially available oral formulation. Rectal quetiapine produced an area under the plasma concentration-time curve from time zero to infinity (AUC∞) approximately 90 % greater than that produced by an equal (milligram per milligram) dose of oral quetiapine (15,333 ng/mL versus 8118.8 ng/mL, p = 0.005). However, only two of ten subjects who received topical quetiapine had detectable serum levels. When detected, serum levels achieved with topical quetiapine were delayed and low in comparison with those produced by the oral and rectal dosage forms. Our results suggest that rectal, but not topical, quetiapine may be useful in clinical settings. Clinical outcome studies of rectal quetiapine are needed.
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NASA Technical Reports Server (NTRS)
Schmahl, E. J.; Kundu, M. R.; Dennis, B. R.
1985-01-01
A solar limb flare was mapped using the Very Large Array (VLA) together with hard X-ray (HXR) spectral and spatial observations of the Solar Maximum Mission satellite. Microwave flux records from 2.8 to 19.6 GHz were instrumental in determining the burst spectrum, which has a maximum at 10 GHz. The flux spectrum and area of the burst sources were used to determine the number of electrons producing gyrosynchrotron emission, magnetic field strength, and the energy distribution of gyrosynchrotron-emitting electrons. Applying the thick target model to the HXR spectrum, the number of high energy electrons responsible for the X-ray bursts was found to be 10 to the 36th, and the electron energy distribution was approximately E exp -5, significantly different from the parameters derived from the microwave observations. The HXR imaging observations exhibit some similiarities in size and structure o the first two burst sources mapped with the VLA. However, during the initial burst, the HXR source was single and lower in the corona than the double 6 cm source. The observations are explained in terms of a single loop with an isotropic high-energy electron distribution which produced the microwaves, and a larger beamed component which produced the HXR at the feet of the loop.
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Low Prevalence of carbapenem-resistant Enterobacteriaceae among wounded military personnel.
Mende, Katrin; Beckius, Miriam L; Zera, Wendy C; Onmus-Leone, Fatma; Murray, Clinton K; Tribble, David R
2017-01-01
Multidrug-resistant organisms (MDROs) are a global health problem that affect both civilian and military populations. Among wounded warriors, MDROs further complicate the care of trauma-related infections, resulting in extended duration of hospitalization, as well as increased morbidity and mortality. During the wars in Iraq and Afghanistan, extended spectrum β-lactamase-producing Enterobacteriaceae were frequently isolated from wounded warriors. The potential emergence of difficult-to-treat carbapenem-resistant Enterobacteriaceae represented a serious challenge for clinicians. We examined carbapenem-resistant Enterobacteriaceae prevalence among wounded military personnel over a 6-year period (2009-2015). Among 4090 Enterobacteriaceae isolates collected, 16 (0.4%) were carbapenem-resistant, of which the majority was Enterobacter aerogenes (44%) followed by Klebsiella pneumoniae (37%), and Escherichia coli (19%). Five isolates (31%) collected from 2 patients were carbapenemase-producers with one associated with an infection. All 5 carbapenemase-producing isolates were resistant to all tested carbapenems and each carried one carbapenemase gene (4 with blaKPC-3 and 1 with blaNDM-1). Overall, although a large number of Enterobacteriaceae isolates were collected, only a small proportion was carbapenem-resistant and data indicate a lack of a cluster. Due to these limited numbers, it is difficult to make any conclusions regarding the association between carbapenem resistance, antibiotic exposure, and clinical outcomes.
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Ontology Alignment Repair through Modularization and Confidence-Based Heuristics
Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M.
2015-01-01
Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system. PMID:26710335
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Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.
Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M
2015-01-01
Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system.
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Small, D M; Bond, M G; Waugh, D; Prack, M; Sawyer, J K
1984-01-01
To identify the temporal changes occurring during progression and regression of atherosclerosis in nonhuman primates, we have studied the physicochemical and histological characteristics of arterial wall lesions during a 30-mo progression period of diet-induced hypercholesterolemia and during a 12-mo period of regression. Three groups of cynomolgous monkeys (Macaca fascicularis) were studied. Control groups were fed a basal chow diet for 18, 24, and 30 mo and were compared with progression groups that were fed a high-cholesterol-containing diet for up to 30 mo. Regression groups were fed a high-cholesterol diet for 18 mo to induce atherosclerosis and then fed monkey chow for up to 12 mo. The progression group monkeys were killed at 6, 12, 18, 24, and 30 mo, and the regression animals were killed at 24 and 30 mo (i.e., after 6 and 12 mo of being fed a noncholesterol-containing chow diet). Histology and morphometry, physical microscopy for cholesterol monohydrate crystals, foam cell and droplet melting points and chemical composition studies were completed on a large number of individual arterial lesions. Control animals had very little cholesterol ester, rare foam cells, and no extracellular cholesterol ester droplets or cholesterol crystals. During progression, the arteries first increased cholesterol ester content to produce high melting (approximately 45 degrees C) foam cell-rich lesions essentially devoid of cholesterol crystals. With time, the number of cholesterol crystals increased so that by 30 mo large numbers were present. Foam cells decreased with time but their melting temperature remained high while that of extracellular droplets fell to approximately 38 degrees C. Between 18 and 30 mo necrosis appeared and worsened. After 6-mo regression, unexpected changes occurred in the lesions. Compared with 24-mo progression, the chemical composition showed a relative increase in free cholesterol, a decrease in cholesterol ester and microscopy revealed large numbers of cholesterol crystals. Concomitantly, foam cells decreased and the melting temperature of both intra- and extracellular cholesterol ester markedly decreased. After 12-mo regression cholesterol decreased, cholesterol crystals and necrosis diminished and collagen appeared increased. Thus, during progression there is initially an increase in the number of foam cells containing very high-melting intracellular cholesterol ester droplets. By 30 mo, cholesterol crystals and necrosis dominate and high-melting foam cells appear only at lesion margins, suggesting that the initial process continues at the lesion edge. The lower melting point of extracellular esters indicates a lipid composition different from intracellular droplets. Thus, the changes observed in these animals generally reflect those predicted for progression of human atherosclerosis. During the initial 6 mo of regression, necrosis remains, the number of foam cell decreases, and cholesterol ester content decreases; however the relative proportion of free cholesterol content increases, and large numbers of cholesterol content are formed. Thus, large and rapid decreases in serum cholesterol concentration to produce regression in fact may result in the precipitation of cholesterol monohydrate and an apparent worsening of the lesions. More prolonged regression (12-mo) tends to return the lipid composition of the artery wall towards normal, partially reduces cholesterol crystals, and results in an improved but scarred intima. Images PMID:6725553
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The Stability of Radiatively Cooling Jets. 2: Nonlinear Evolution
NASA Technical Reports Server (NTRS)
Stone, James M.; Xu, Jianjun; Hardee, Philip
1997-01-01
We use two-dimensional time-dependent hydrodynamical simulations to follow the growth of the Kelvin-Helmholtz (K-H) instability in cooling jets into the nonlinear regime. We focus primarily on asymmetric modes that give rise to transverse displacements of the jet beam. A variety of Mach numbers and two different cooling curves are studied. The growth rates of waves in the linear regime measured from the numerical simulations are in excellent agreement with the predictions of the linear stability analysis presented in the first paper in this series. In the nonlinear regime, the simulations show that asymmetric modes of the K-H instability can affect the structure and evolution of cooling jets in a number of ways. We find that jets in which the growth rate of the sinusoidal surface wave has a maximum at a so-called resonant frequency can be dominated by large-amplitude sinusoidal oscillations near this frequency. Eventually, growth of this wave can disrupt the jet. On the other hand, nonlinear body waves tend to produce low-amplitude wiggles in the shape of the jet but can result in strong shocks in the jet beam. In cooling jets, these shocks can produce dense knots and filaments of cooling gas within the jet. Ripples in the surface of the jet beam caused by both surface and body waves generate oblique shock "spurs" driven into the ambient gas. Our simulations show these shock "spurs" can accelerate ambient gas at large distances from the jet beam to low velocities, which represents a new mechanism by which low-velocity bipolar outflows may be driven by high-velocity jets. Rapid entrainment and acceleration of ambient gas may also occur if the jet is disrupted. For parameters typical of protostellar jets, the frequency at which K-H growth is a maximum (or highest frequency to which the entire jet can respond dynamically) will be associated with perturbations with a period of - 200 yr. Higher frequency (shorter period) perturbations excite waves associated with body modes that produce internal shocks and only small-amplitude wiggles within the jet. The fact that most observed systems show no evidence for large-amplitude sinusoidal oscillation leading to disruption is indicative that the perturbation frequencies are generally large, consistent with the suggestion that pro- tostellar jets arise from the inner regions (r less than 1 AU) of accretion disks.
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Evink, T L; Endres, M I
2017-11-01
Recent trends in dairy farm structure in the United States have included a decreasing number of farms, although farm size has increased, especially the share of milk production from very large herds (>2,500 cows). The objectives of this observational study were to describe common management practices; to characterize labor and operational structure; to measure some aspects of animal health, including lameness, hock lesions, mortality, and mastitis incidence; and to summarize cost of production on farms with more than 2,500 cows in 4 states in the Upper Midwest of the United States. The study included 15 dairy farms in Minnesota, Wisconsin, Iowa, and South Dakota. Farms were visited twice, once each year, and on-farm herd records were collected for those 2 yr. On-farm herd records were used to investigate mortality, culling, pregnancy rate, and clinical mastitis incidence. At least 1 high-producing pen of mature cows and 1 pen of fresh cows were scored for locomotion. Likewise, at least 1 pen of high-producing mature cows was scored for cleanliness and hock lesions. Median herd size was 3,975 cows (range = 2,606-13,266). Milk sold per employee was 1,120,745 kg and the number of cows per employee was 105. Eighty percent of the farms had Holstein cows, 13% had Jersey, and 7% had Jersey-Holstein crosses. All farms used artificial insemination as the sole form of breeding and 100% of the farms used hormonal synchronization or timed artificial insemination programs in their reproductive protocols; 21-d pregnancy rate was 21.7%. Median lameness prevalence was 18.3% and median severe lameness prevalence was 5.1%. Median hock lesion prevalence was 17.4% and median severe hock lesion prevalence was 1.9%; mortality rate was 7.4%. Clinical mastitis incidence was 62.5 cases per 100 cow-years. Feed costs accounted for approximately 53% of the total cost of producing milk, followed by labor at 11%, interest and depreciation expenses at 10%, and replacement costs at 9.5%. Herds in the top 50th percentile for profitability had a net income of $2.40 per hundredweight of milk sold compared with $0.95 per hundredweight for herds in the bottom 50th percentile. Although results of this study were helpful in understanding how large dairy systems operate in the Upper Midwest, more research is yet needed with a larger number of farms and wider variety of management practices to identify factors within these large farms that promote optimal animal health and profitability. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
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NASA Technical Reports Server (NTRS)
Sawyer, Richard H.; Trant, James P., Jr.
1950-01-01
An investigation was made by the NACA wing-flow method to determine the drag, pitching-moment, lift, and angle-of-attack characteristics at transonic speeds of various configurations of a semispan model of an early configuration of the XF7U-1 tailless airplane. The results of the tests indicated that for the basic configuration with undeflected ailavator, the zero-lift drag rise occurred at a Mach number of about 0.85 and that about a five-fold increase in drag occurred through the transonic speed range. The results of the tests also indicated that the drag increment produced by -8.0 degrees deflection of the ailavator increased with increase in normal-force coefficient and was smaller at speeds above than at speeds below the drag rise. The drag increment produced by 35 degree deflection of the speed brakes varied from 0.040 to 0.074 depending on the normal-force coefficient and Mach number. These values correspond to drag coefficients of about 0.40 and 0.75 based on speed-brake frontal area. Removal of the fin produced a small positive drag increment at a given normal-force coefficient at speeds during the drag rise. A large forward shift of the neutral-point location occurred at Mach numbers above about 0.90 upon removal of the fin, and also a considerable forward shift throughout the Mach number range occurred upon deflection of the speed brakes. Ailavator ineffectiveness or reversal at low deflections, similar to that determined in previous tests of the basic configuration of the model in the Mach number range from about 0.93 to 1.0, was found for the fin-off configuration and for the model equipped with skewed (more highly sweptback) hinge-line ailavators. With the speed brakes deflected, little or no loss in the incremental pitching moment produced by deflection of the ailavator from O degrees to -8.00 degrees occurred in the Mach number range from 0.85 to 1.0 in contrast to a considerable loss found in previous tests with the speed brakes off.
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Symbol recognition produced by points of tactile stimulation: the illusion of linear continuity.
Gonzales, G R
1996-11-01
To determine whether tactile receptive communication is possible through the use of a mechanical device that produces the phi phenomenon on the body surface. Twenty-six subjects (11 blind and 15 sighted participants) were tested with use of a tactile communication device (TCD) that produces an illusion of linear continuity forming numbers on the dorsal aspect of the wrist. Recognition of a number or number set was the goal. A TCD with protruding and vibrating solenoids produced sequentially delivered points of cutaneous stimulation along a pattern resembling numbers and created the illusion of dragging a vibrating stylet to form numbers, similar to what might be felt by testing for graphesthesia. Blind subjects recognized numbers with fewer trials than did sighted subjects, although all subjects were able to recognize all the numbers produced by the TCD. Subjects who had been blind since birth and had no prior tactile exposure to numbers were able to draw the numbers after experiencing them delivered by the TCD even though they did not recognize their meaning. The phi phenomenon is probably responsible for the illusion of continuous lines in the shape of numbers as produced by the TCD. This tactile illusion could potentially be used for more complex tactile communications such as letters and words.
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Lazzari, Giovanna; Wrenzycki, Christine; Herrmann, Doris; Duchi, Roberto; Kruip, Theo; Niemann, Heiner; Galli, Cesare
2002-09-01
The large offspring syndrome (LOS) is observed in bovine and ovine offspring following transfer of in vitro-produced (IVP) or cloned embryos and is characterized by a multitude of pathologic changes, of which extended gestation length and increased birthweight are predominant features. In the present study, we used bovine blastocysts to analyze cellular parameters, i.e., the number of cells in Day 7 blastocysts and the size of Day 12 elongating blastocysts, and molecular parameters, i.e., the relative abundance of developmentally important genes: glucose transporter (Glut) 1, Glut-2, Glut-3, Glut-4, heat shock protein (Hsp) 70.1, Cu/Zn-superoxide dismutase (SOD), histone H4.1, basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF) I receptor (R), and IGFII-R. Some blastocysts were produced by in vitro maturation and fertilization followed by in vitro culture in synthetic oviduct fluid medium supplemented with BSA or human serum or by in vivo culture in the sheep oviduct. Other blastocysts were derived in vivo from the uterine horns of superovulated donors. The findings made in the early embryos were related to a representative number of calves obtained from each production system and from artificial insemination (AI). In vitro culture of bovine embryos in the presence of high concentrations of serum or BSA significantly increased the number of cells in Day 7 blastocysts, the size of blastocysts on Day 12, and the relative abundance of the transcripts for Hsp70.1, Cu/Zn-SOD, Glut-3, Glut-4, bFGF, and IGFI-R when compared with embryos from the in vivo production groups. Birthweights of calves derived from IVP embryos were significantly higher than those of calves derived from sheep oviduct culture, superovulation, or AI. The results support the hypothesis that persistence of early deviations in development is causally involved in the incidence of LOS, in particular in increased birthweights. The cellular and molecular parameters analyzed in this study can be considered early markers of LOS in cattle.
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A classification of morphoseismic features in the New Madrid seismic zone
DOE Office of Scientific and Technical Information (OSTI.GOV)
Knox, R.; Stewart, D.
1993-03-01
The New Madrid Seismic Zone (NMSZ) contains thousands of surface features distributed over 5,000 square miles in four states. These are attributable to some combination of (1) seismically-induced liquefaction (SIL), (2) secondary deformation, and (3) seismically-induced slope failures. Most of these features were produced by the 1811--12 series of great earthquakes, but some predate and some postdate 1811--12. Subsequent non-seismic factors, such as hydrologically-induced liquefaction (HIL), mechanically-induced liquefaction (MIL), human activities, mass wasting, eolian and fluvial processes have modified all of these features. Morphoseismic features are new landforms produced by earthquakes, or are pre-existing landforms modified by them. Involved aremore » complex interrelationships among several variables, including: (1) intensity and duration of seismic ground motion, (2) surface wave harmonics, (3) depth to water table, (4) depth to basement, (5) particle size, composition, and sorting of sediment making up the liquefied (LZ) and non-liquefied zones (NLZ), (6) topographic parameters, and (7) attitudes of beds and lenses susceptible to liquefaction. Morphoseismic features are depicted as results of a time-flow sequence initiated by primary basement disturbances which produce three major categories of surface response: secondary deformation, liquefaction and slope failure. Nine subcategories incorporate features produced by or resulting in: extruded sand, intruded sand, lateral spreading, faulting, subsidence of large areas, uplift of large areas, altered streams, coherent landslides, and incoherent landslides. The total morphoseismic features identified by this classification are 34 in number.« less
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Bioactive Metabolites from Pathogenic and Endophytic Fungi of Forest Trees.
Masi, Marco; Maddau, Lucia; Linaldeddu, Benedetto Teodoro; Scanu, Bruno; Evidente, Antonio; Cimmino, Alessio
2018-01-01
Fungi play an important role in terrestrial ecosystems interacting positively or negatively with plants. These interactions are complex and the outcomes are different depending on the fungal lifestyles, saprotrophic, mutualistic or pathogenic. Furthermore, fungi are well known for producing secondary metabolites, originating from different biosynthetic pathways, which possess biological properties of considerable biotechnological interest. Among the terrestrial ecosystems, temperate forests represent an enormous reservoir of fungal diversity. This review will highlight the goldmine of secondary metabolites produced by pathogenic and endophytic fungi of forest trees with focus on their biological activities. A structured search of bibliographic databases for peer-reviewed research literature was undertaken using a research discovery application providing access to a large and authoritative source of references. The papers selected were examined and the main results were reported and discussed. Two hundred forthy-one papers were included in the review, outlined a large number of secondary metabolites produced by pathogenic and endophiltic fungi and their biological activities, including phytotoxic, antifungal, antioomycetes, antibacterial, brine shrimp lethality, mosquito biting deterrence and larvicidal, cytotoxic, antiproliferative and many other bioactivities. The findings of this review confirm the importance of secondary metabolites produced by pathogenic and endophytic fungi from forest plants growing in temperate regions as an excellent prospects to discover compounds with new bioactivities and mode of actions. In addition, the potential of some metabolites as a source of new drugs and biopesticides is underlined. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
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Smith, Robert W; van Rosmalen, Rik P; Martins Dos Santos, Vitor A P; Fleck, Christian
2018-06-19
Models of metabolism are often used in biotechnology and pharmaceutical research to identify drug targets or increase the direct production of valuable compounds. Due to the complexity of large metabolic systems, a number of conclusions have been drawn using mathematical methods with simplifying assumptions. For example, constraint-based models describe changes of internal concentrations that occur much quicker than alterations in cell physiology. Thus, metabolite concentrations and reaction fluxes are fixed to constant values. This greatly reduces the mathematical complexity, while providing a reasonably good description of the system in steady state. However, without a large number of constraints, many different flux sets can describe the optimal model and we obtain no information on how metabolite levels dynamically change. Thus, to accurately determine what is taking place within the cell, finer quality data and more detailed models need to be constructed. In this paper we present a computational framework, DMPy, that uses a network scheme as input to automatically search for kinetic rates and produce a mathematical model that describes temporal changes of metabolite fluxes. The parameter search utilises several online databases to find measured reaction parameters. From this, we take advantage of previous modelling efforts, such as Parameter Balancing, to produce an initial mathematical model of a metabolic pathway. We analyse the effect of parameter uncertainty on model dynamics and test how recent flux-based model reduction techniques alter system properties. To our knowledge this is the first time such analysis has been performed on large models of metabolism. Our results highlight that good estimates of at least 80% of the reaction rates are required to accurately model metabolic systems. Furthermore, reducing the size of the model by grouping reactions together based on fluxes alters the resulting system dynamics. The presented pipeline automates the modelling process for large metabolic networks. From this, users can simulate their pathway of interest and obtain a better understanding of how altering conditions influences cellular dynamics. By testing the effects of different parameterisations we are also able to provide suggestions to help construct more accurate models of complete metabolic systems in the future.
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Pulse shape optimization for electron-positron production in rotating fields
NASA Astrophysics Data System (ADS)
Fillion-Gourdeau, François; Hebenstreit, Florian; Gagnon, Denis; MacLean, Steve
2017-07-01
We optimize the pulse shape and polarization of time-dependent electric fields to maximize the production of electron-positron pairs via strong field quantum electrodynamics processes. The pulse is parametrized in Fourier space by a B -spline polynomial basis, which results in a relatively low-dimensional parameter space while still allowing for a large number of electric field modes. The optimization is performed by using a parallel implementation of the differential evolution, one of the most efficient metaheuristic algorithms. The computational performance of the numerical method and the results on pair production are compared with a local multistart optimization algorithm. These techniques allow us to determine the pulse shape and field polarization that maximize the number of produced pairs in computationally accessible regimes.
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On the tidal effects in the motion of earth satellites and the love parameters of the earth
NASA Technical Reports Server (NTRS)
Musen, P.; Estes, R.
1972-01-01
The tidal effects in the motion of artificial satellites are studied to determine the elastic properties of the earth as they are observed from extraterrestrial space. Considering Love numbers, the disturbing potential is obtained as the analytical continuation of the tidal potential from the surface of the earth into-outer space, with parameters which characterize the earth's elastic response to tidal attraction by the moon and the sun. It is concluded that the tidal effects represent a superposition of a large number of periodic terms, and the rotation of the lunar orbital plane produces a term of 18 years period in tidal perturbations of the ascending node of the satellite's orbit.
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NASA Technical Reports Server (NTRS)
Ellison, D. C.; Jones, F. C.; Eichler, D.
1983-01-01
Both hydrodynamic calculations (Drury and Volk, 1981, and Axford et al., 1982) and kinetic simulations imply the existence of thermal subshocks in high-Mach-number cosmic-ray-mediated shocks. The injection efficiency of particles from the thermal background into the diffusive shock-acceleration process is determined in part by the sharpness and compression ratio of these subshocks. Results are reported for a Monte Carlo simulation that includes both the back reaction of accelerated particles on the inflowing plasma, producing a smoothing of the shock transition, and the free escape of particles allowing arbitrarily large overall compression ratios in high-Mach-number steady-state shocks. Energy spectra and estimates of the proportion of thermal ions accelerated to high energy are obtained.
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Hallerman, E M; Nave, A; Soller, M; Beckmann, J S
1988-12-01
Genomic DNA of Israeli Holstein-Friesian dairy cattle were screened with a battery of 17 cloned or subcloned DNA probes in an attempt to document restriction fragment length polymorphisms at a number of genetic loci. Restriction fragment length polymorphisms were observed at the chymosin, oxytocin-neurophysin I, lutropin beta, keratin III, keratin VI, keratin VII, prolactin, and dihydrofolate reductase loci. Use of certain genomic DNA fragments as probes produced hybridization patterns indicative of satellite DNA at the respective loci. Means for distinguishing hybridizations to coding sequences for unique genes from those to satellite DNA were developed. Results of this study are discussed in terms of strategy for the systematic development of large numbers of bovine genomic polymorphisms.
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NASA Astrophysics Data System (ADS)
Ellison, D. C.; Jones, F. C.; Eichler, D.
1983-08-01
Both hydrodynamic calculations (Drury and Volk, 1981, and Axford et al., 1982) and kinetic simulations imply the existence of thermal subshocks in high-Mach-number cosmic-ray-mediated shocks. The injection efficiency of particles from the thermal background into the diffusive shock-acceleration process is determined in part by the sharpness and compression ratio of these subshocks. Results are reported for a Monte Carlo simulation that includes both the back reaction of accelerated particles on the inflowing plasma, producing a smoothing of the shock transition, and the free escape of particles allowing arbitrarily large overall compression ratios in high-Mach-number steady-state shocks. Energy spectra and estimates of the proportion of thermal ions accelerated to high energy are obtained.
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Bubble deformations and segmented flows in corrugated microchannels at large capillary numbers
NASA Astrophysics Data System (ADS)
Sauzade, Martin; Cubaud, Thomas
2018-03-01
We experimentally investigate the interaction between individual bubble deformations and collective distortions of segmented flows in nonlinear microfluidic geometries. Using highly viscous carrier fluids, we study the evolution of monodisperse trains of gas bubbles from a square to a smoothly corrugated microchannel characterized with a series of extensions and constrictions along the flow path. The hysteresis in the bubble shape between accelerating and decelerating flow fields is shown to increase with the capillary number. Measurements of instantaneous bubble velocities reveal the presence of a capillary pull that produces a nonmonotonic behavior for the front velocity in accelerating flow regions. Functional relationships are developed for predicting the morphology and dynamics of viscous multiphase flow patterns at the pore scale.
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Front End for a neutrino factory or muon collider
Neuffer, David; Snopok, Pavel; Alexahin, Yuri
2017-11-30
A neutrino factory or muon collider requires the capture and cooling of a large number of muons. Scenarios for capture, bunching, phase-energy rotation and initial cooling of μ’s produced from a proton source target have been developed, initially for neutrino factory scenarios. They require a drift section from the target, a bunching section and a Φ-δE rotation section leading into the cooling channel. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport. The currently preferred cooling channel design is an “HFOFO Snake” configuration that cools both μ + and μ - transversely andmore » longitudinally. Finally, the status of the design is presented and variations are discussed.« less
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Design data for radars based on 13.9 GHz Skylab scattering coefficient measurements
NASA Technical Reports Server (NTRS)
Moore, R. K. (Principal Investigator)
1974-01-01
The author has identified the following significant results. Measurements made at 13.9 GHz with the radar scatterometer on Skylab have been combined to produce median curves of the variation of scattering coefficient with angle of incidence out to 45 deg. Because of the large number of observations, and the large area averaged for each measured data point, these curves may be used as a new design base for radars. A reasonably good fit at larger angles is obtained using the theoretical expression based on an exponential height correlation function and also using Lambert's law. For angles under 10 deg, a different fit based on the exponential correlation function, and a fit based on geometric optics expressions are both reasonably valid.
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Formation of multiply charged ions from large molecules using massive-cluster impact.
Mahoney, J F; Cornett, D S; Lee, T D
1994-05-01
Massive-cluster impact is demonstrated to be an effective ionization technique for the mass analysis of proteins as large as 17 kDa. The design of the cluster source permits coupling to both magnetic-sector and quadrupole mass spectrometers. Mass spectra are characterized by the almost total absence of chemical background and a predominance of multiply charged ions formed from 100% glycerol matrix. The number of charge states produced by the technique is observed to range from +3 to +9 for chicken egg lysozyme (14,310 Da). The lower m/z values provided by higher charge states increase the effective mass range of analyses performed with conventional ionization by fast-atom bombardment or liquid secondary ion mass spectrometry.
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Variation in the production rate of biosonar signals in freshwater porpoises.
Kimura, Satoko; Akamatsu, Tomonari; Wang, Ding; Li, Songhai; Wang, Kexiong; Yoda, Ken
2013-05-01
The biosonar (click train) production rate of ten Yangtze finless porpoises and their behavior were examined using animal-borne data loggers. The sound production rate varied from 0 to 290 click trains per 10-min time interval. Large individual differences were observed, regardless of body size. Taken together, however, sound production did not differ significantly between daytime and nighttime. Over the 172.5 h of analyzed recordings, an average of 99.0% of the click trains were produced within intervals of less than 60 s, indicating that during a 1-min interval, the number of click trains produced by each porpoise was typically greater than one. Most of the porpoises exhibited differences in average swimming speed and depth between day and night. Swimming speed reductions and usage of short-range sonar, which relates to prey-capture attempts, were observed more often during nighttime. However, biosonar appears to be affected not only by porpoise foraging, but also by their sensory environment, i.e., the turbid Yangtze River system. These features will be useful for passive acoustic detection of the porpoises. Calculations of porpoise density or abundance should be conducted carefully because large individual differences in the sound production rate will lead to large estimation error.
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Vorticity Transfer in Shock Wave Interactions with Turbulence and Vortices
NASA Astrophysics Data System (ADS)
Agui, J. H.; Andreopoulos, J.
1998-11-01
Time-dependent, three-dimensional vorticity measurements of shock waves interacting with grid generated turbulence and concentrated tip vortices were conducted in a large diameter shock tube facility. Two different mesh size grids and a NACA-0012 semi-span wing acting as a tip vortex generator were used to carry out different relative Mach number interactions. The turbulence interactions produced a clear amplification of the lateral and spanwise vorticity rms, while the longitudinal component remained mostly unaffected. By comparison, the tip vortex/shock wave interactions produced a two fold increase in the rms of longitudinal vorticity. Considerable attention was given to the vorticity source terms. The mean and rms of the vorticity stretching terms dominated by 5 to 7 orders of magnitude over the dilitational compression terms in all the interactions. All three signals of the stretching terms manifested very intermittent, large amplitude peak events which indicated the bursting character of the stretching process. Distributions of these signals were characterized by extremely large levels of flatness with varying degrees of skewness. These distribution patterns were found to change only slightly through the turbulence interactions. However, the tip vortex/shock wave interactions brought about significant changes in these distributions which were associated with the abrupt structural changes of the vortex after the interaction.
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Bernstein wave aided laser third harmonic generation in a plasma
NASA Astrophysics Data System (ADS)
Tyagi, Yachna; Tripathi, Deepak; Kumar, Ashok
2016-09-01
The process of Bernstein wave aided resonant third harmonic generation of laser in a magnetized plasma is investigated. The extra-ordinary mode (X-mode) laser of frequency ω 0 and wave number k → 0 , travelling across the magnetic field in a plasma, exerts a second harmonic ponderomotive force on the electrons imparting them an oscillatory velocity v → 2 ω0 , 2 k → 0 . This velocity beats with the density perturbation due to the Bernstein wave to produce a density perturbation at cyclotron frequency shifted second harmonic. The density perturbation couples with the oscillatory velocity v → ω0 , k → 0 of X-mode of the laser to produce the cyclotron frequency shifted third harmonic current density leading to harmonic radiation. The phase matching condition for the up shifted frequency is satisfied when the Bernstein wave is nearly counter-propagating to the laser. As the transverse wave number of the Bernstein wave is large, it is effective in the phase matched third harmonic generation, when the laser frequency is not too far from the upper hybrid frequency.
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Living on the edge: Fig tree phenology at the northern range limit of monoecious Ficus in China
NASA Astrophysics Data System (ADS)
Zhang, Lu-Shui; Compton, Stephen G.; Xiao, Hui; Lu, Qian; Chen, Yan
2014-05-01
Fig trees (Ficus) are a species-rich group of mainly tropical and subtropical plants that are of ecological importance because of the large numbers of vertebrates that utilise their figs for food. Factors limiting their distributions to warmer regions are still poorly understood, but are likely to include factors linked to their specialised pollination biology, because each Ficus species is dependent on one or a small number of host-specific fig wasps (Agaonidae) for pollination. Adult fig wasps are short-lived, but some species are capable of dispersing extremely long distances to pollinate their hosts. Close to its northern range limit we investigated the phenology of Ficus virens, the monoecious fig tree that reaches furthest north in China. Relatively few trees produced any figs, and very few retained figs throughout the winter. Despite this, new crops produced in spring were pollinated, with seasonally migrant pollinators from plants growing further south the most likely pollen vectors. An inability to initiate new crops at low temperatures may limit the distribution of monoecious fig trees to warmer areas.
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Klett, T.R.; Charpentier, Ronald R.
2003-01-01
The USGS FORSPAN model is designed for the assessment of continuous accumulations of crude oil, natural gas, and natural gas liquids (collectively called petroleum). Continuous (also called ?unconventional?) accumulations have large spatial dimensions and lack well defined down-dip petroleum/water contacts. Oil and natural gas therefore are not localized by buoyancy in water in these accumulations. Continuous accumulations include ?tight gas reservoirs,? coalbed gas, oil and gas in shale, oil and gas in chalk, and shallow biogenic gas. The FORSPAN model treats a continuous accumulation as a collection of petroleumcontaining cells for assessment purposes. Each cell is capable of producing oil or gas, but the cells may vary significantly from one another in their production (and thus economic) characteristics. The potential additions to reserves from continuous petroleum resources are calculated by statistically combining probability distributions of the estimated number of untested cells having the potential for additions to reserves with the estimated volume of oil and natural gas that each of the untested cells may potentially produce (total recovery). One such statistical method for combination of number of cells with total recovery, used by the USGS, is called ACCESS.
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Ion Implantation with in-situ Patterning for IBC Solar Cells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Graff, John W.
2014-10-24
Interdigitated back-side Contact (IBC) solar cells are the highest efficiency silicon solar cells currently on the market. Unfortunately the cost to produce these solar cells is also very high, due to the large number of processing steps required. Varian believes that only the combination of high efficiency and low cost can meet the stated goal of $1/Wp. The core of this program has been to develop an in-situ patterning capability for an ion implantation system capable of producing patterned doped regions for IBC solar cells. Such a patterning capable ion implanter can reduce the number of process steps required tomore » manufacture IBC cells, and therefore significantly reduce the cost. The present program was organized into three phases. Phase I was to select a patterning approach and determine the patterning requirements for IBC cells. Phase II consists of construction of a Beta ion implantation system containing in-situ patterning capability. Phase III consists of shipping and installation of the ion implant system in a customer factory where it will be tested and proven in a pilot production line.« less
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NASA Technical Reports Server (NTRS)
Hymer, W. C.; Grindeland, R.; Hayes, C.; Lanham, J. W.; Cleveland, C.; Todd, P.; Morrison, Dennis R.
1988-01-01
The cell separation techniques of velocity sedimentation, flow cytometry and continuous flow electrophoresis were used to obtain enriched populations of growth hormone (GH) cells. The goal was to isolate a GH cell subpopulation which releases GH molecules which are very high in biological activity, it was important to use a method which was effective in processing large numbers of cells over a short time span. The techniques based on sedimentation are limited by cell density overlaps and streaming. While flow cytometry is useful in the analytical mode for objectively establishing cell purity, the numbers of cells which can be processed in the sort mode are so small as to make this approach ineffective in terms of the long term goals. It was shown that continuous flow electrophoresis systems (CFES) can separate GH cells from other cell types on the basis of differences in surface charge. The bioreactive producers appear to be more electrophoretically mobile than the low producers. Current ground based CFES efforts are hampered by cell clumping in low ionic strength buffers and poor cell recoveries from the CFES device.
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DOE R&D Accomplishments Database
Bloch, F.; Staub, H.
1943-08-18
Measurements of the spectrum of the fission neutrons of 25 are described, in which the energy of the neutrons is determined from the ionization produced by individual hydrogen recoils. The slow neutrons producing fission are obtained by slowing down the fast neutrons from the Be-D reaction of the Stanford cyclotron. In order to distinguish between fission neutrons and the remaining fast cyclotron neutrons both the cyclotron current and the pusle amplifier are modulated. A hollow neutron container, in which slow neutrons have a lifetime of about 2 milliseconds, avoids the use of large distances. This method results in much higher intensities than the usual modulation arrangement. The results show a continuous distribution of neutrons with a rather wide maximum at about 0.8 MV falling off to half of its maximum value at 2.0 MV. The total number of netrons is determined by comparison with the number of fission fragments. The result seems to indicate that only about 30% of the neutrons have energies below .8 MV. Various tests are described which were performed in order to rule out modification of the spectrum by inelastic scattering. Decl. May 4, 1951
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Maluta, Jaqueline R.; Machado, Sergio A. S.; Chaudhary, Umesh
The modification of traditional electrodes with mesoporous carbons is a promising strategy to produce high performance electrodes for electrochemical sensing. The high surface area of mesoporous carbons provides a large number of electroactive sites for binding analytes. Controlling the pore size and structure of mesoporous carbons and modifying their electronic properties via doping offers additional benefits like maximizing transport and tuning the electrochemical processes associated with analyte detection. This work reports a facile method to produce sulfur-doped ordered mesoporous carbon materials (S-OMC) with uniform pore structure, large pore volume, high surface area and semigraphitic structure. The synthesis used thiophenol asmore » a single source of carbon and sulfur, and iron as a catalyst for low temperature carbonization. The S-OMC material was deposited on a glassy carbon electrode and used as a sensor with high sensitivity (11.7 A L mol-1) and selectivity for chloramphenicol detection in presence of other antibiotics. As a proof-of-concept, the sensor was applied to the direct analysis of the drug in reconstituted powdered milk and in commercial eye drops.« less
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Maluta, Jaqueline R.; Machado, Sergio A. S.; Chaudhary, Umesh; ...
2017-10-29
The modification of traditional electrodes with mesoporous carbons is a promising strategy to produce high performance electrodes for electrochemical sensing. The high surface area of mesoporous carbons provides a large number of electroactive sites for binding analytes. Controlling the pore size and structure of mesoporous carbons and modifying their electronic properties via doping offers additional benefits like maximizing transport and tuning the electrochemical processes associated with analyte detection. This work reports a facile method to produce sulfur-doped ordered mesoporous carbon materials (S-OMC) with uniform pore structure, large pore volume, high surface area and semigraphitic structure. The synthesis used thiophenol asmore » a single source of carbon and sulfur, and iron as a catalyst for low temperature carbonization. The S-OMC material was deposited on a glassy carbon electrode and used as a sensor with high sensitivity (11.7 A L mol-1) and selectivity for chloramphenicol detection in presence of other antibiotics. As a proof-of-concept, the sensor was applied to the direct analysis of the drug in reconstituted powdered milk and in commercial eye drops.« less
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How thermal inflation can save minimal hybrid inflation in supergravity
DOE Office of Scientific and Technical Information (OSTI.GOV)
Dimopoulos, Konstantinos; Owen, Charlotte
2016-10-12
Minimal hybrid inflation in supergravity has been ruled out by the 2015 Planck observations because the spectral index of the produced curvature perturbation falls outside observational bounds. To resurrect the model, a number of modifications have been put forward but many of them spoil the accidental cancellation that resolves the η-problem and require complicated Kähler constructions to counterbalance the lost cancellation. In contrast, in this paper the model is rendered viable by supplementing the scenario with a brief period of thermal inflation, which follows the reheating of primordial inflation. The scalar field responsible for thermal inflation requires a large non-zeromore » vacuum expectation value (VEV) and a flat potential. We investigate the VEV of such a flaton field and its subsequent effect on the inflationary observables. We find that, for large VEV, minimal hybrid inflation in supergravity produces a spectral index within the 1-σ Planck bound and a tensor-to-scalar ratio which may be observable in the near future. The mechanism is applicable to other inflationary models.« less
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Coarse-grained models of key self-assembly processes in HIV-1
NASA Astrophysics Data System (ADS)
Grime, John
Computational molecular simulations can elucidate microscopic information that is inaccessible to conventional experimental techniques. However, many processes occur over time and length scales that are beyond the current capabilities of atomic-resolution molecular dynamics (MD). One such process is the self-assembly of the HIV-1 viral capsid, a biological structure that is crucial to viral infectivity. The nucleation and growth of capsid structures requires the interaction of large numbers of capsid proteins within a complicated molecular environment. Coarse-grained (CG) models, where degrees of freedom are removed to produce more computationally efficient models, can in principle access large-scale phenomena such as the nucleation and growth of HIV-1 capsid lattice. We report here studies of the self-assembly behaviors of a CG model of HIV-1 capsid protein, including the influence of the local molecular environment on nucleation and growth processes. Our results suggest a multi-stage process, involving several characteristic structures, eventually producing metastable capsid lattice morphologies that are amenable to subsequent capsid dissociation in order to transmit the viral infection.
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Exploring metabolic pathways in genome-scale networks via generating flux modes.
Rezola, A; de Figueiredo, L F; Brock, M; Pey, J; Podhorski, A; Wittmann, C; Schuster, S; Bockmayr, A; Planes, F J
2011-02-15
The reconstruction of metabolic networks at the genome scale has allowed the analysis of metabolic pathways at an unprecedented level of complexity. Elementary flux modes (EFMs) are an appropriate concept for such analysis. However, their number grows in a combinatorial fashion as the size of the metabolic network increases, which renders the application of EFMs approach to large metabolic networks difficult. Novel methods are expected to deal with such complexity. In this article, we present a novel optimization-based method for determining a minimal generating set of EFMs, i.e. a convex basis. We show that a subset of elements of this convex basis can be effectively computed even in large metabolic networks. Our method was applied to examine the structure of pathways producing lysine in Escherichia coli. We obtained a more varied and informative set of pathways in comparison with existing methods. In addition, an alternative pathway to produce lysine was identified using a detour via propionyl-CoA, which shows the predictive power of our novel approach. The source code in C++ is available upon request.
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CO2 Enhanced Oil Recovery from the Residual Zone - A Sustainable Vision for North Sea Oil Production
NASA Astrophysics Data System (ADS)
Stewart, Jamie; Haszeldine, Stuart; Wilkinson, Mark; Johnson, Gareth
2014-05-01
This paper presents a 'new vision for North Sea oil production' where previously unattainable residual oil can be produced with the injection of CO2 that has been captured at power stations or other large industrial emitters. Not only could this process produce incremental oil from a maturing basin, reducing imports, it also has the capability to store large volumes of CO2 which can offset the emissions of additional carbon produced. Around the world oil production from mature basins is in decline and production from UK oil fields peaked in 1998. Other basins around the world have a similar story. Although in the UK a number of tax regimes, such as 'brown field allowances' and 'new field allowances' have been put in place to re-encourage investment, it is recognised that the majority of large discoveries have already been made. However, as a nation our demand for oil remains high and in the last decade imports of crude oil have been steadily increasing. The UK is dependent on crude oil for transport and feedstock for chemical and plastics production. Combined with the necessity to provide energy security, there is a demand to re-assess the potential for CO2 Enhanced Oil Recovery (CO2-EOR) in the UK offshore. Residual oil zones (ROZ) exist where one of a number of natural conditions beyond normal capillary forces have caused the geometry of a field's oil column to be altered after filling [1]. When this re-structuring happens the primary interest to the hydrocarbon industry has in the past been in where the mobile oil has migrated to. However it is now considered that significant oil resource may exist in the residual zone play where the main oil column has been displaced. Saturations within this play are predominantly close to residual saturation (Sr) and would be similar to that of a water-flooded field [2]. Evidence from a number of hydrocarbon fairways shows that, under certain circumstances, these residual zones in US fields are comparable in thickness to the conventional oil. The application of CO2EOR to ROZ enables a significant contribution to a field's recoverable reserves [3]. This work identifies for the first time the plays of geological conditions that create naturally occurring residual oil zones in the United Kingdom Continental Shelf. We present a screening workflow to identify such zones and a methodology for assessing the resource potential and CO2 storage capacity for a number of different fields. Lastly we examine the economic consequences on CO2 storage of the incremental oil produced, and the carbon balance life-cycle. [1] Melzer, S., Koperna, G., Kuuskraa, V. 2006. The Origin and Resource Potential of Residual Oil Zones. SPE Annual and Technical Conference, San Antonio, Texas, Society. [2] Koperna, G., Melzer. S.L., Kuuskraa, V. 2006. Recovery of Oil Resources From the Residual and Transitional Oil Zones of the Permian Basin.. SPE Annual Technical Conference, San Antonia, Texas. Society of Petroleum Engineers. [3] Advanced Resources International, 2005. Assessing Technical and Economic Recovery of Residual Oil Zones. U.S Department of Energy.
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Shielding materials for highly penetrating space radiations
NASA Technical Reports Server (NTRS)
Kiefer, Richard L.; Orwoll, Robert A.
1995-01-01
Interplanetary travel involves the transfer from an Earth orbit to a solar orbit. Once outside the Earth's magnetosphere, the major sources of particulate radiation are solar cosmic rays (SCR's) and galactic cosmic rays (GCR's). Intense fluxes of SCR's come from solar flares and consist primarily of protons with energies up to 1 GeV. The GCR consists of a low flux of nuclei with energies up to 10(exp 10) GeV. About 70 percent of the GCR are protons, but a small amount (0.6 percent) are nuclei with atomic numbers greater than 10. High energy charged particles (HZE) interact with matter by transferring energy to atomic electrons in a Coulomb process and by reacting with an atomic nucleus. Energy transferred in the first process increases with the square of the atomic number, so particles with high atomic numbers would be expected to lose large amounts of energy by this process. Nuclear reactions produced by (HZE) particles produce high-energy secondary particles which in turn lose energy to the material. The HZE nuclei are a major concern for radiation protection of humans during interplanetary missions because of the very high specific ionization of both primary and secondary particles. Computer codes have been developed to calculate the deposition of energy by very energetic charged particles in various materials. Calculations show that there is a significant buildup of secondary particles from nuclear fragmentation and Coulomb dissociation processes. A large portion of these particles are neutrons. Since neutrons carry no charge, they only lose energy by collision or reaction with a nucleus. Neutrons with high energies transfer large amounts of energy by inelastic collisions with nuclei. However, as the neutron energy decreases, elastic collisions become much more effective for energy loss. The lighter the nucleus, the greater the fraction of the neutron's kinetic energy that can be lost in an elastic collision. Thus, hydrogen-containing materials such as polymers are most effective in reducing the energy of neutrons. Once neutrons are reduced to very low energies, the probability for undergoing a reaction with a nucleus (the cross section) becomes very high. The product of such a reaction is often radioactive and can involve the release of a significant amount of energy. Thus, it is important to provide protection from low energy neutrons during a long duration space flight. Among the light elements, lithium and boron each have an isotope with a large thermal neutron capture cross section, Li-6 and B-10. However, B-10 is more abundant in the naturally-occurring element than Li-6, has a thermal neutron capture cross section four times that of Li-6, and produces the stable products, He-4 and Li-7 in the interaction while Li-6 produces radioactive tritium (H-3). Thus, boron is the best light-weight material for thermal neutron absorption in spacecraft. The work on this project was focused in two areas: computer design where existing computer codes were used, and in some cases modified, to calculate the propagation and interactions of high energy charged particles through various media, and materials development where boron was incorporated into high performance materials.
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Bybee, Seth M; Bracken-Grissom, Heather; Haynes, Benjamin D; Hermansen, Russell A; Byers, Robert L; Clement, Mark J; Udall, Joshua A; Wilcox, Edward R; Crandall, Keith A
2011-01-01
Next-gen sequencing technologies have revolutionized data collection in genetic studies and advanced genome biology to novel frontiers. However, to date, next-gen technologies have been used principally for whole genome sequencing and transcriptome sequencing. Yet many questions in population genetics and systematics rely on sequencing specific genes of known function or diversity levels. Here, we describe a targeted amplicon sequencing (TAS) approach capitalizing on next-gen capacity to sequence large numbers of targeted gene regions from a large number of samples. Our TAS approach is easily scalable, simple in execution, neither time-nor labor-intensive, relatively inexpensive, and can be applied to a broad diversity of organisms and/or genes. Our TAS approach includes a bioinformatic application, BarcodeCrucher, to take raw next-gen sequence reads and perform quality control checks and convert the data into FASTA format organized by gene and sample, ready for phylogenetic analyses. We demonstrate our approach by sequencing targeted genes of known phylogenetic utility to estimate a phylogeny for the Pancrustacea. We generated data from 44 taxa using 68 different 10-bp multiplexing identifiers. The overall quality of data produced was robust and was informative for phylogeny estimation. The potential for this method to produce copious amounts of data from a single 454 plate (e.g., 325 taxa for 24 loci) significantly reduces sequencing expenses incurred from traditional Sanger sequencing. We further discuss the advantages and disadvantages of this method, while offering suggestions to enhance the approach.
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Food appropriation through large scale land acquisitions
NASA Astrophysics Data System (ADS)
Rulli, Maria Cristina; D'Odorico, Paolo
2014-05-01
The increasing demand for agricultural products and the uncertainty of international food markets has recently drawn the attention of governments and agribusiness firms toward investments in productive agricultural land, mostly in the developing world. The targeted countries are typically located in regions that have remained only marginally utilized because of lack of modern technology. It is expected that in the long run large scale land acquisitions (LSLAs) for commercial farming will bring the technology required to close the existing crops yield gaps. While the extent of the acquired land and the associated appropriation of freshwater resources have been investigated in detail, the amount of food this land can produce and the number of people it could feed still need to be quantified. Here we use a unique dataset of land deals to provide a global quantitative assessment of the rates of crop and food appropriation potentially associated with LSLAs. We show how up to 300-550 million people could be fed by crops grown in the acquired land, should these investments in agriculture improve crop production and close the yield gap. In contrast, about 190-370 million people could be supported by this land without closing of the yield gap. These numbers raise some concern because the food produced in the acquired land is typically exported to other regions, while the target countries exhibit high levels of malnourishment. Conversely, if used for domestic consumption, the crops harvested in the acquired land could ensure food security to the local populations.
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Stereo reconstruction from multiperspective panoramas.
Li, Yin; Shum, Heung-Yeung; Tang, Chi-Keung; Szeliski, Richard
2004-01-01
A new approach to computing a panoramic (360 degrees) depth map is presented in this paper. Our approach uses a large collection of images taken by a camera whose motion has been constrained to planar concentric circles. We resample regular perspective images to produce a set of multiperspective panoramas and then compute depth maps directly from these resampled panoramas. Our panoramas sample uniformly in three dimensions: rotation angle, inverse radial distance, and vertical elevation. The use of multiperspective panoramas eliminates the limited overlap present in the original input images and, thus, problems as in conventional multibaseline stereo can be avoided. Our approach differs from stereo matching of single-perspective panoramic images taken from different locations, where the epipolar constraints are sine curves. For our multiperspective panoramas, the epipolar geometry, to the first order approximation, consists of horizontal lines. Therefore, any traditional stereo algorithm can be applied to multiperspective panoramas with little modification. In this paper, we describe two reconstruction algorithms. The first is a cylinder sweep algorithm that uses a small number of resampled multiperspective panoramas to obtain dense 3D reconstruction. The second algorithm, in contrast, uses a large number of multiperspective panoramas and takes advantage of the approximate horizontal epipolar geometry inherent in multiperspective panoramas. It comprises a novel and efficient 1D multibaseline matching technique, followed by tensor voting to extract the depth surface. Experiments show that our algorithms are capable of producing comparable high quality depth maps which can be used for applications such as view interpolation.
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Bybee, Seth M.; Bracken-Grissom, Heather; Haynes, Benjamin D.; Hermansen, Russell A.; Byers, Robert L.; Clement, Mark J.; Udall, Joshua A.; Wilcox, Edward R.; Crandall, Keith A.
2011-01-01
Next-gen sequencing technologies have revolutionized data collection in genetic studies and advanced genome biology to novel frontiers. However, to date, next-gen technologies have been used principally for whole genome sequencing and transcriptome sequencing. Yet many questions in population genetics and systematics rely on sequencing specific genes of known function or diversity levels. Here, we describe a targeted amplicon sequencing (TAS) approach capitalizing on next-gen capacity to sequence large numbers of targeted gene regions from a large number of samples. Our TAS approach is easily scalable, simple in execution, neither time-nor labor-intensive, relatively inexpensive, and can be applied to a broad diversity of organisms and/or genes. Our TAS approach includes a bioinformatic application, BarcodeCrucher, to take raw next-gen sequence reads and perform quality control checks and convert the data into FASTA format organized by gene and sample, ready for phylogenetic analyses. We demonstrate our approach by sequencing targeted genes of known phylogenetic utility to estimate a phylogeny for the Pancrustacea. We generated data from 44 taxa using 68 different 10-bp multiplexing identifiers. The overall quality of data produced was robust and was informative for phylogeny estimation. The potential for this method to produce copious amounts of data from a single 454 plate (e.g., 325 taxa for 24 loci) significantly reduces sequencing expenses incurred from traditional Sanger sequencing. We further discuss the advantages and disadvantages of this method, while offering suggestions to enhance the approach. PMID:22002916
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Incidence and epidemiology of Citrus tristeza virus in the Valencian community of Spain.
Cambra, M; Gorris, M T; Marroquín, C; Román, M P; Olmos, A; Martínez, M C; de Mendoza, A H; López, A; Navarro, L
2000-11-01
The first outbreak of citrus tristeza disease in Spain caused by Citrus tristeza virus (CTV) was recorded in 1957 in the Valencian Community (VC). In total c. 40 million trees, mainly of sweet orange and mandarin grafted on sour orange rootstocks, declined due to CTV. Large-scale surveys in different municipalities of the VC indicated that the disease spread very fast. Incidence increased from 11% in 1989 to 53% in 1998. Toxoptera aurantii and Aphis spiraecola (inefficient aphid vectors of CTV) predominated before 1985-87. Since then the relatively efficient vector Aphis gossypii has become dominant and induced an epidemic that has been modelled. The large number of A.gossypii that visited each clementine tree (estimated to exceed 97000 per year) explained the difference between the temporal pattern of spread of CTV in clementine which followed the Gompertz model and that in sweet orange (logistic model). The susceptibility of the different citrus species to CTV infection by aphids seems to depend on the number of young, succulent shoots produced. The epidemiological data allowed specific recommendations to be made to growers in order to facilitate a change to a modern citrus industry based on the use of selected varieties grafted on tristeza-tolerant rootstocks produced within a certification scheme. This has been done already in almost 90% of the VC citrus-growing area. The tristeza problem has been solved unless more aggressive isolates are introduced and become prevalent.
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[How five-year-old children distribute rewards: effects of the amount of reward and a crying face].
Tsutsu, Kiyomi
2013-10-01
Five-year-old children were presented with two scenes in which one character made three stars and the other made nine stars. In one of the scenes, both characters' facial expressions were neutral (neutral face scene), and in the other scene the character who produced three stars had a crying face (crying face scene). Children distributed different numbers of rewards to the two characters: equal to (Middle-N), less than (Small-N), or more than (Large-N) the total number of stars in each scene. Then the children were asked for their reason after they distributed the rewards. It was found that (a) the participants' distributions depended on the total number of rewards but (b) not on the characters' facial expressions, and (c) the justifications of their distributions in the Middle-N condition were different between the scenes. These results suggest that the total number of rewards triggers an automatic distribution process, and that an ex post facto justification takes place when needed.
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NASA Astrophysics Data System (ADS)
Ahmad, Saeed; Holopainen, Hannu; Huovinen, Pasi
2017-05-01
In hydrodynamical modeling of ultrarelativistic heavy-ion collisions, the freeze-out is typically assumed to take place at a surface of constant temperature or energy density. A more physical approach is to assume that freeze-out takes place at a surface of constant Knudsen number. We evaluate the Knudsen number as a ratio of the expansion rate of the system to the pion-scattering rate and apply the constant Knudsen number freeze-out criterion to the ideal hydrodynamical description of heavy-ion collisions at the Relativistic Heavy Ion Collider at BNL (√{sNN}=200 GeV) and the Large Hadron Collider (√{sNN}=2760 GeV) energies. We see that once the numerical values of freeze-out temperature and freeze-out Knudsen number are chosen to produce similar pT distributions, the elliptic and triangular anisotropies are similar too, in both event-by-event and averaged initial state calculations.
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Flying insect detection and classification with inexpensive sensors.
Chen, Yanping; Why, Adena; Batista, Gustavo; Mafra-Neto, Agenor; Keogh, Eamonn
2014-10-15
An inexpensive, noninvasive system that could accurately classify flying insects would have important implications for entomological research, and allow for the development of many useful applications in vector and pest control for both medical and agricultural entomology. Given this, the last sixty years have seen many research efforts devoted to this task. To date, however, none of this research has had a lasting impact. In this work, we show that pseudo-acoustic optical sensors can produce superior data; that additional features, both intrinsic and extrinsic to the insect's flight behavior, can be exploited to improve insect classification; that a Bayesian classification approach allows to efficiently learn classification models that are very robust to over-fitting, and a general classification framework allows to easily incorporate arbitrary number of features. We demonstrate the findings with large-scale experiments that dwarf all previous works combined, as measured by the number of insects and the number of species considered.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Brewer, Brendon J.; Foreman-Mackey, Daniel; Hogg, David W., E-mail: bj.brewer@auckland.ac.nz
We present and implement a probabilistic (Bayesian) method for producing catalogs from images of stellar fields. The method is capable of inferring the number of sources N in the image and can also handle the challenges introduced by noise, overlapping sources, and an unknown point-spread function. The luminosity function of the stars can also be inferred, even when the precise luminosity of each star is uncertain, via the use of a hierarchical Bayesian model. The computational feasibility of the method is demonstrated on two simulated images with different numbers of stars. We find that our method successfully recovers the inputmore » parameter values along with principled uncertainties even when the field is crowded. We also compare our results with those obtained from the SExtractor software. While the two approaches largely agree about the fluxes of the bright stars, the Bayesian approach provides more accurate inferences about the faint stars and the number of stars, particularly in the crowded case.« less
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Flying Insect Detection and Classification with Inexpensive Sensors
Chen, Yanping; Why, Adena; Batista, Gustavo; Mafra-Neto, Agenor; Keogh, Eamonn
2014-01-01
An inexpensive, noninvasive system that could accurately classify flying insects would have important implications for entomological research, and allow for the development of many useful applications in vector and pest control for both medical and agricultural entomology. Given this, the last sixty years have seen many research efforts devoted to this task. To date, however, none of this research has had a lasting impact. In this work, we show that pseudo-acoustic optical sensors can produce superior data; that additional features, both intrinsic and extrinsic to the insect’s flight behavior, can be exploited to improve insect classification; that a Bayesian classification approach allows to efficiently learn classification models that are very robust to over-fitting, and a general classification framework allows to easily incorporate arbitrary number of features. We demonstrate the findings with large-scale experiments that dwarf all previous works combined, as measured by the number of insects and the number of species considered. PMID:25350921