Applications of Electromigration Techniques: Applications of Electromigration Techniques in Food Analysis

NASA Astrophysics Data System (ADS)

Wieczorek, Piotr; Ligor, Magdalena; Buszewski, Bogusław

Electromigration techniques, including capillary electrophoresis (CE), are widely used for separation and identification of compounds present in food products. These techniques may also be considered as alternate and complementary with respect to commonly used analytical techniques, such as high-performance liquid chromatography (HPLC), or gas chromatography (GC). Applications of CE concern the determination of high-molecular compounds, like polyphenols, including flavonoids, pigments, vitamins, food additives (preservatives, antioxidants, sweeteners, artificial pigments) are presented. Also, the method developed for the determination of proteins and peptides composed of amino acids, which are basic components of food products, are studied. Other substances such as carbohydrates, nucleic acids, biogenic amines, natural toxins, and other contaminations including pesticides and antibiotics are discussed. The possibility of CE application in food control laboratories, where analysis of the composition of food and food products are conducted, is of great importance. CE technique may be used during the control of technological processes in the food industry and for the identification of numerous compounds present in food. Due to the numerous advantages of the CE technique it is successfully used in routine food analysis.

Europa Lander Material Selection Considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tappan, Alexander S.; Heller, Mellisa

2017-01-10

Energetic materials (EMs, explosives, pyrotechnics, propellants) provide high-power output of high temperature reaction products. These products can be solid, liquid, or gaseous during reaction or after the products have equilibrated with the surroundings. For example, high explosives typically consist of carbon, hydrogen, nitrogen, and oxygen bonded within a single molecule, and produce almost exclusively gaseous products. Conversely, intermetallics consist of physical mixtures of metals and metalloids, and produce almost exclusively condensed products. Other materials such as pyrotechnics and propellants have intermediate behavior. All energetic materials react in a self-propagating manner that after ignition, does not necessarily require energy input frommore » the surroundings. The range of reaction velocities can range from mm/s for intermetallics, to km/s for high explosives. Energetic material selection depends on numerous requirements specific to the needs of a system. High explosives are used for applications where high pressure gases are necessary for pushing or fracturing materials (e.g., rock, metal) or creating shock waves or air blast. Propellants are used to produce moderate-pressure, high-temperature products without a shock wave. Pyrotechnics are used to produce numerous effects including: high-temperature products, gases, light, smoke, sound, and others. Thermites are used to produce heat, high-temperature products, materials, and other effects that require condensed products. Intermetallics are used to produce high-temperature condensed products and materials, with very little gas production. Numerous categories of energetic materials exist with overlapping definitions, effects, and properties.« less

Lipid encapsulated phenolics

USDA-ARS?s Scientific Manuscript database

Phenolic compounds have numerous health benefits when included in the human diet and have emerged as a functional food and feed additive. Current sources of phenolics include commodity grains such as corn, oat, and wheat but may also be obtained as a co-product from agricultural residues and other l...

Numerical Simulation Of Silicon-Ribbon Growth

NASA Technical Reports Server (NTRS)

Woda, Ben K.; Kuo, Chin-Po; Utku, Senol; Ray, Sujit Kumar

1987-01-01

Mathematical model includes nonlinear effects. In development simulates growth of silicon ribbon from melt. Takes account of entire temperature and stress history of ribbon. Numerical simulations performed with new model helps in search for temperature distribution, pulling speed, and other conditions favoring growth of wide, flat, relatively defect-free silicon ribbons for solar photovoltaic cells at economically attractive, high production rates. Also applicable to materials other than silicon.

High-conversion hydrolysates and corn sweetener production in dry-grind corn process.

USDA-ARS?s Scientific Manuscript database

Most corn is processed to fuel ethanol and distillers’ grain animal feed using the dry grind process. However, wet milling is needed to refine corn starch. Corn starch is in turn processed to numerous products, including glucose and syrup. However, wet milling is a capital, labor, and energy intensi...

Defeating Insurgencies with Minimal Force Ratios

DTIC Science & Technology

2013-06-14

articles; US Government produced products , and comprehensive books on the insurgencies with a focus on El Salvador. Unlike Sri Lanka, most of the...of funding for conflict as well as US policy guidance for the issue can be found products created by numerous US Government entities, to include the...younger leaders, and information sharing with their neighbors.35 Rapid transformation, as evidenced by the Sri Lanka Navy, was a product of the

A Qualitative Investigation of Adults' Perceived Benefits, Barriers and Strategies for Consuming Milk and Milk Products

ERIC Educational Resources Information Center

Jung, Mary E.; Mistry, Chetan; Bourne, Jessica E.; Perrier, Marie-Josee; Martin Ginis, Kathleen A.; Latimer-Cheung, Amy E.

2015-01-01

Objective: Milk and milk products provide important nutrients and have been associated with numerous health benefits in addition to bone health, including a healthy weight and a reduction of risk for certain conditions such as type 2 diabetes, hypertension, cardiovascular disease and colorectal cancer. Nonetheless, consumption of milk and milk…

Screening of a virtual mirror-image library of natural products.

PubMed

Noguchi, Taro; Oishi, Shinya; Honda, Kaori; Kondoh, Yasumitsu; Saito, Tamio; Ohno, Hiroaki; Osada, Hiroyuki; Fujii, Nobutaka

2016-06-08

We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

A Production Function Approach to Regional Environmental-Economic Assessments

EPA Science Inventory

Numerous difficulties await those creating regional-scale environmental assessments, from data having inconsistent spatial or temporal scales to poorly understood environmental processes and indicators. Including socioeconomic variables further complicates the situation. In place...

Comprehensive numerical methodology for direct numerical simulations of compressible Rayleigh-Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reckinger, Scott James; Livescu, Daniel; Vasilyev, Oleg V.

A comprehensive numerical methodology has been developed that handles the challenges introduced by considering the compressive nature of Rayleigh-Taylor instability (RTI) systems, which include sharp interfacial density gradients on strongly stratified background states, acoustic wave generation and removal at computational boundaries, and stratification-dependent vorticity production. The computational framework is used to simulate two-dimensional single-mode RTI to extreme late-times for a wide range of flow compressibility and variable density effects. The results show that flow compressibility acts to reduce the growth of RTI for low Atwood numbers, as predicted from linear stability analysis.

Simulation analysis of an integrated model for dynamic cellular manufacturing system

NASA Astrophysics Data System (ADS)

Hao, Chunfeng; Luan, Shichao; Kong, Jili

2017-05-01

Application of dynamic cellular manufacturing system (DCMS) is a well-known strategy to improve manufacturing efficiency in the production environment with high variety and low volume of production. Often, neither the trade-off of inter and intra-cell material movements nor the trade-off of hiring and firing of operators are examined in details. This paper presents simulation results of an integrated mixed-integer model including sensitivity analysis for several numerical examples. The comprehensive model includes cell formation, inter and intracellular materials handling, inventory and backorder holding, operator assignment (including resource adjustment) and flexible production routing. The model considers multi-production planning with flexible resources (machines and operators) where each period has different demands. The results verify the validity and sensitivity of the proposed model using a genetic algorithm.

The generation and use of numerical shape models for irregular Solar System objects

NASA Technical Reports Server (NTRS)

Simonelli, Damon P.; Thomas, Peter C.; Carcich, Brian T.; Veverka, Joseph

1993-01-01

We describe a procedure that allows the efficient generation of numerical shape models for irregular Solar System objects, where a numerical model is simply a table of evenly spaced body-centered latitudes and longitudes and their associated radii. This modeling technique uses a combination of data from limbs, terminators, and control points, and produces shape models that have some important advantages over analytical shape models. Accurate numerical shape models make it feasible to study irregular objects with a wide range of standard scientific analysis techniques. These applications include the determination of moments of inertia and surface gravity, the mapping of surface locations and structural orientations, photometric measurement and analysis, the reprojection and mosaicking of digital images, and the generation of albedo maps. The capabilities of our modeling procedure are illustrated through the development of an accurate numerical shape model for Phobos and the production of a global, high-resolution, high-pass-filtered digital image mosaic of this Martian moon. Other irregular objects that have been modeled, or are being modeled, include the asteroid Gaspra and the satellites Deimos, Amalthea, Epimetheus, Janus, Hyperion, and Proteus.

Overview Presentation

NASA Technical Reports Server (NTRS)

Lytle, John

2001-01-01

This report provides an overview presentation of the 2000 NPSS (Numerical Propulsion System Simulation) Review and Planning Meeting. Topics include: 1) a background of the program; 2) 1999 Industry Feedback; 3) FY00 Status, including resource distribution and major accomplishments; 4) FY01 Major Milestones; and 5) Future direction for the program. Specifically, simulation environment/production software and NPSS CORBA Security Development are discussed.

PPPC 4 DMν: a Poor Particle Physicist Cookbook for Neutrinos from Dark Matter annihilations in the Sun

NASA Astrophysics Data System (ADS)

Baratella, Pietro; Cirelli, Marco; Hektor, Andi; Pata, Joosep; Piibeleht, Morten; Strumia, Alessandro

2014-03-01

We provide ingredients and recipes for computing neutrino signals of TeV-scale Dark Matter (DM) annihilations in the Sun. For each annihilation channel and DM mass we present the energy spectra of neutrinos at production, including: state-of-the-art energy losses of primary particles in solar matter, secondary neutrinos, electroweak radiation. We then present the spectra after propagation to the Earth, including (vacuum and matter) flavor oscillations and interactions in solar matter. We also provide a numerical computation of the capture rate of DM particles in the Sun. These results are available in numerical form.

Numerical analysis of the unintegrated double gluon distribution

NASA Astrophysics Data System (ADS)

Elias, Edgar; Golec-Biernat, Krzysztof; Staśto, Anna M.

2018-01-01

We present detailed numerical analysis of the unintegrated double gluon distribution which includes the dependence on the transverse momenta of partons. The unintegrated double gluon distribution was obtained following the Kimber-Martin-Ryskin method as a convolution of the perturbative gluon splitting function with the collinear integrated double gluon distribution and the Sudakov form factors. We analyze the dependence on the transverse momenta, longitudinal momentum fractions and hard scales. We find that the unintegrated gluon distribution factorizes into a product of two single unintegrated gluon distributions in the region of small values of x, provided the splitting contribution is included and the momentum sum rule is satisfied.

Stability and growth of continental shields in mantle convection models including recurrent melt production

NASA Astrophysics Data System (ADS)

de Smet, J. H.; van den Berg, A. P.; Vlaar, N. J.

1998-10-01

The long-term growth and stability of compositionally layered continental upper mantle has been investigated by numerical modelling. We present the first numerical model of a convecting mantle including differentiation through partial melting resulting in a stable compositionally layered continental upper mantle structure. This structure includes a continental root extending to a depth of about 200 km. The model covers the upper mantle including the crust and incorporates physical features important for the study of the continental upper mantle during secular cooling of the Earth since the Archaean. Among these features are: a partial melt generation mechanism allowing consistent recurrent melting, time-dependent non-uniform radiogenic heat production, and a temperature- and pressure-dependent rheology. The numerical results reveal a long-term growth mechanism of the continental compositional root. This mechanism operates through episodical injection of small diapiric upwellings from the deep layer of undepleted mantle into the continental root which consists of compositionally distinct depleted mantle material. Our modelling results show the layered continental structure to remain stable during at least 1.5 Ga. After this period mantle differentiation through partial melting ceases due to the prolonged secular cooling and small-scale instabilities set in through continental delamination. This stable period of 1.5 Ga is related to a number of limitations in our model. By improving on these limitations in the future this stable period will be extended to more realistic values.

Ponderomotive effects in multiphoton pair production

NASA Astrophysics Data System (ADS)

Kohlfürst, Christian; Alkofer, Reinhard

2018-02-01

The Dirac-Heisenberg-Wigner formalism is employed to investigate electron-positron pair production in cylindrically symmetric but otherwise spatially inhomogeneous, oscillating electric fields. The oscillation frequencies are hereby tuned to obtain multiphoton pair production in the nonperturbative threshold regime. An effective mass, as well as a trajectory-based semiclassical analysis, is introduced in order to interpret the numerical results for the distribution functions as well as for the particle yields and spectra. The results, including the asymptotic particle spectra, display clear signatures of ponderomotive forces.

CE-QUAL-W2: A Numerical Two-Dimensional, Laterally Averaged Model of Hydrodynamics and Water Quality; User’s Manual.

DTIC Science & Technology

1986-08-01

publication by Ms. Jessica S. Ruff, Information Products Division, WES. This manual is published in loose-leaf format for convenience in ." ._ periodic...transfer computations. m. Variety of output options. Background 8. This manual is a product of a program of evaluation and refinement of mathematical water...zooplankton and higher order herbivores. However, these groups are presently not included in the model. Macrophyte production may also have an impact upon

Bioactive natural products from Chinese marine flora and fauna.

PubMed

Zhou, Zhen-Fang; Guo, Yue-Wei

2012-09-01

In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione.

PubMed

Senadhi, Viplove; Arora, Deepika; Arora, Manish; Marsh, Franklin

2012-08-27

The Food and Drug Administration (FDA) has issued a warning on numerous herbal drugs, including many popular products at General Nutrition Centers (GNC), regarding unstudied hepatotoxicity. There have been recent reports of GNC products such as hydroxycut and herbalife, causing drug-induced hepatitis. Herbal medications are over-the-counter products and are not investigated thoroughly by the FDA. Given that the most common outpatient laboratory abnormality is elevated liver transaminases, a sign of hepatocellular toxicity; it is not surprising that some of these products end up causing hepatic dysfunction, especially when taken in large volume. There are numerous herbal supplements that are hepatotoxic, however, these medications have a much more significant effect in human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome patients, which is secondary to depleted glutathione. We present a rare case of drug induced hepatitis secondary to herbal medications used to treat HIV and elucidate the role of glutathione depletion in immunocompromised patients.

A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione

PubMed Central

Senadhi, Viplove; Arora, Deepika; Arora, Manish; Marsh, Franklin

2012-01-01

The Food and Drug Administration (FDA) has issued a warning on numerous herbal drugs, including many popular products at General Nutrition Centers (GNC), regarding unstudied hepatotoxicity. There have been recent reports of GNC products such as hydroxycut and herbalife, causing drug-induced hepatitis. Herbal medications are over-the-counter products and are not investigated thoroughly by the FDA. Given that the most common outpatient laboratory abnormality is elevated liver transaminases, a sign of hepatocellular toxicity; it is not surprising that some of these products end up causing hepatic dysfunction, especially when taken in large volume. There are numerous herbal supplements that are hepatotoxic, however, these medications have a much more significant effect in human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome patients, which is secondary to depleted glutathione. We present a rare case of drug induced hepatitis secondary to herbal medications used to treat HIV and elucidate the role of glutathione depletion in immunocompromised patients. PMID:22993667

Quantum mechanical calculations of vibrational population inversion in chemical reactions - Numerically exact L-squared-amplitude-density study of the H2Br reactive system

NASA Technical Reports Server (NTRS)

Zhang, Y. C.; Zhang, J. Z. H.; Kouri, D. J.; Haug, K.; Schwenke, D. W.

1988-01-01

Numerically exact, fully three-dimensional quantum mechanicl reactive scattering calculations are reported for the H2Br system. Both the exchange (H + H-prime Br to H-prime + HBr) and abstraction (H + HBR to H2 + Br) reaction channels are included in the calculations. The present results are the first completely converged three-dimensional quantum calculations for a system involving a highly exoergic reaction channel (the abstraction process). It is found that the production of vibrationally hot H2 in the abstraction reaction, and hence the extent of population inversion in the products, is a sensitive function of initial HBr rotational state and collision energy.

The Bioethanol Industry in Sub-Saharan Africa: History, Challenges, and Prospects

PubMed Central

Deenanath, Evanie Devi; Iyuke, Sunny; Rumbold, Karl

2012-01-01

Recently, interest in using bioethanol as an alternative to petroleum fuel has been escalating due to decrease in the availability of crude oil. The application of bioethanol in the motor-fuel industry can contribute to reduction in the use of fossil fuels and in turn to decreased carbon emissions and stress of the rapid decline in crude oil availability. Bioethanol production methods are numerous and vary with the types of feedstock used. Feedstocks can be cereal grains (first generation feedstock), lignocellulose (second generation feedstock), or algae (third generation feedstock) feedstocks. To date, USA and Brazil are the leading contributors to global bioethanol production. In sub-Saharan Africa, bioethanol production is stagnant. During the 1980s, bioethanol production has been successful in several countries including Zimbabwe, Malawi, and Kenya. However, because of numerous challenges such as food security, land availability, and government policies, achieving sustainability was a major hurdle. This paper examines the history and challenges of bioethanol production in sub-Saharan Africa (SSA) and demonstrates the bioethanol production potential in SSA with a focus on using bitter sorghum and cashew apple juice as unconventional feedstocks for bioethanol production. PMID:22536020

Technology utilization in a non-urban region: Further impact and technique of the Technology Use Center

NASA Technical Reports Server (NTRS)

Gold, C. H.; Moore, A. M.; Dodd, B.; Marshall, R.; West, S. G.

1978-01-01

Performance information for the center is reported. The search production during the reporting period exceeds the production record of the center during any period in its 14 year history. A performance average of 30 searches per month, which represents an increase of 45%, is reported. Numerical listings of the searches processed are given. A section of transfer and impact report is included.

Forecasting Winter Storms in the Sierra: A Social Science Perspective in Keeping the Public Safe without Negatively Impacting the Local Tourism Industry

NASA Astrophysics Data System (ADS)

Milne, R.; Wallmann, J.; Myrick, D. T.

2010-12-01

The National Weather Service Office in Reno is responsible for issuing Blizzard Warnings, Winter Storm Warnings, and Winter Weather Advisories for the Sierra, including the Lake Tahoe Basin and heavily traveled routes such as Interstate 80, Highway 395 and Highway 50. These forecast products prepare motorists for harsh travel conditions as well as those venturing into the backcountry, which are essential to the NWS mission of saving lives and property. During the winter season, millions of people from around the world visit the numerous world class ski resorts in the Sierra and the Lake Tahoe Basin, which is vital to the local economy. This situation creates a challenging decision for the forecasters to provide appropriate wording in winter statements to keep the public safe, without significantly impacting the local tourism-based economy. Numerous text and graphical products, including online weather briefings, are utilized by NWS Reno to highlight hazards in ensuring the public, businesses, and other government agencies are prepared for winter storms and take appropriate safety measures. The effectiveness of these product types will be explored, with past snowstorms used as examples to show how forecasters determine which type of text or graphical product is most appropriate to convey the hazardous weather threats.

Research strategies for safety evaluation of nanomaterials, part VII: evaluating consumer exposure to nanoscale materials.

PubMed

Thomas, Treye; Thomas, Karluss; Sadrieh, Nakissa; Savage, Nora; Adair, Patricia; Bronaugh, Robert

2006-05-01

Considerable media attention has recently been given to novel applications for products that contain nanoscale materials. These products could have utility in several industries that market consumer products, including textiles, sporting equipment, cosmetics, consumer electronics, and household cleaners. Some of the purported benefits of these products include improved performance, convenience, lower cost, as well as other desirable features, when compared to the conventional products that do not contain nanoscale materials. Although there are numerous likely consumer advantages from products containing nanoscale materials, there is very little information available regarding consumer exposure to the nanoscale materials in these products or any associated risks from these exposures. This paper seeks to review a limited subset of products that contain nanoscale materials, assess the available data for evaluating the consumer exposures and potential hazards associated with these products, and discuss the capacity of U.S. regulatory agencies to address the potential risks associated with these products.

Power generation based on biomass by combined fermentation and gasification--a new concept derived from experiments and modelling.

PubMed

Methling, Torsten; Armbrust, Nina; Haitz, Thilo; Speidel, Michael; Poboss, Norman; Braun-Unkhoff, Marina; Dieter, Heiko; Kempter-Regel, Brigitte; Kraaij, Gerard; Schliessmann, Ursula; Sterr, Yasemin; Wörner, Antje; Hirth, Thomas; Riedel, Uwe; Scheffknecht, Günter

2014-10-01

A new concept is proposed for combined fermentation (two-stage high-load fermenter) and gasification (two-stage fluidised bed gasifier with CO2 separation) of sewage sludge and wood, and the subsequent utilisation of the biogenic gases in a hybrid power plant, consisting of a solid oxide fuel cell and a gas turbine. The development and optimisation of the important processes of the new concept (fermentation, gasification, utilisation) are reported in detail. For the gas production, process parameters were experimentally and numerically investigated to achieve high conversion rates of biomass. For the product gas utilisation, important combustion properties (laminar flame speed, ignition delay time) were analysed numerically to evaluate machinery operation (reliability, emissions). Furthermore, the coupling of the processes was numerically analysed and optimised by means of integration of heat and mass flows. The high, simulated electrical efficiency of 42% including the conversion of raw biomass is promising for future power generation by biomass. Copyright © 2014 Elsevier Ltd. All rights reserved.

Three Years of Global Positioning System Experience on International Space Station

NASA Technical Reports Server (NTRS)

Gomez, Susan

2005-01-01

The International Space Station global positioning systems (GPS) receiver was activated in April 2002. Since that time, numerous software anomalies surfaced that had to be worked around. Some of the software problems required waivers, such as the time function, while others required extensive operator intervention, such as numerous power cycles. Eventually, enough anomalies surfaced that the three pieces of code included in the GPS unit have been re-written and the GPS units were upgraded. The technical aspects of the problems are discussed, as well as the underlying causes that led to the delivery of a product that has had numerous problems. The technical aspects of the problems included physical phenomena that were not well understood, such as the affect that the ionosphere would have on the GPS measurements. The underlying causes were traced to inappropriate use of legacy software, changing requirements, inadequate software processes, unrealistic schedules, incorrect contract type, and unclear ownership responsibilities.

A non-linear model of economic production processes

NASA Astrophysics Data System (ADS)

Ponzi, A.; Yasutomi, A.; Kaneko, K.

2003-06-01

We present a new two phase model of economic production processes which is a non-linear dynamical version of von Neumann's neoclassical model of production, including a market price-setting phase as well as a production phase. The rate of an economic production process is observed, for the first time, to depend on the minimum of its input supplies. This creates highly non-linear supply and demand dynamics. By numerical simulation, production networks are shown to become unstable when the ratio of different products to total processes increases. This provides some insight into observed stability of competitive capitalist economies in comparison to monopolistic economies. Capitalist economies are also shown to have low unemployment.

Parameter assessment for virtual Stackelberg game in aerodynamic shape optimization

NASA Astrophysics Data System (ADS)

Wang, Jing; Xie, Fangfang; Zheng, Yao; Zhang, Jifa

2018-05-01

In this paper, parametric studies of virtual Stackelberg game (VSG) are conducted to assess the impact of critical parameters on aerodynamic shape optimization, including design cycle, split of design variables and role assignment. Typical numerical cases, including the inverse design and drag reduction design of airfoil, have been carried out. The numerical results confirm the effectiveness and efficiency of VSG. Furthermore, the most significant parameters are identified, e.g. the increase of design cycle can improve the optimization results but it will also add computational burden. These studies will maximize the productivity of the effort in aerodynamic optimization for more complicated engineering problems, such as the multi-element airfoil and wing-body configurations.

An 11-year global gridded aerosol optical thickness reanalysis (v1.0) for atmospheric and climate sciences

NASA Astrophysics Data System (ADS)

Lynch, Peng; Reid, Jeffrey S.; Westphal, Douglas L.; Zhang, Jianglong; Hogan, Timothy F.; Hyer, Edward J.; Curtis, Cynthia A.; Hegg, Dean A.; Shi, Yingxi; Campbell, James R.; Rubin, Juli I.; Sessions, Walter R.; Turk, F. Joseph; Walker, Annette L.

2016-04-01

While stand alone satellite and model aerosol products see wide utilization, there is a significant need in numerous atmospheric and climate applications for a fused product on a regular grid. Aerosol data assimilation is an operational reality at numerous centers, and like meteorological reanalyses, aerosol reanalyses will see significant use in the near future. Here we present a standardized 2003-2013 global 1 × 1° and 6-hourly modal aerosol optical thickness (AOT) reanalysis product. This data set can be applied to basic and applied Earth system science studies of significant aerosol events, aerosol impacts on numerical weather prediction, and electro-optical propagation and sensor performance, among other uses. This paper describes the science of how to develop and score an aerosol reanalysis product. This reanalysis utilizes a modified Navy Aerosol Analysis and Prediction System (NAAPS) at its core and assimilates quality controlled retrievals of AOT from the Moderate Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua and the Multi-angle Imaging SpectroRadiometer (MISR) on Terra. The aerosol source functions, including dust and smoke, were regionally tuned to obtain the best match between the model fine- and coarse-mode AOTs and the Aerosol Robotic Network (AERONET) AOTs. Other model processes, including deposition, were tuned to minimize the AOT difference between the model and satellite AOT. Aerosol wet deposition in the tropics is driven with satellite-retrieved precipitation, rather than the model field. The final reanalyzed fine- and coarse-mode AOT at 550 nm is shown to have good agreement with AERONET observations, with global mean root mean square error around 0.1 for both fine- and coarse-mode AOTs. This paper includes a discussion of issues particular to aerosol reanalyses that make them distinct from standard meteorological reanalyses, considerations for extending such a reanalysis outside of the NASA A-Train era, and examples of how the aerosol reanalysis can be applied or fused with other model or remote sensing products. Finally, the reanalysis is evaluated in comparison with other available studies of aerosol trends, and the implications of this comparison are discussed.

Development studies towards an 11-year global gridded aerosol optical thickness reanalysis for climate and applied applications

NASA Astrophysics Data System (ADS)

Lynch, P.; Reid, J. S.; Westphal, D. L.; Zhang, J.; Hogan, T. F.; Hyer, E. J.; Curtis, C. A.; Hegg, D. A.; Shi, Y.; Campbell, J. R.; Rubin, J. I.; Sessions, W. R.; Turk, F. J.; Walker, A. L.

2015-12-01

While standalone satellite and model aerosol products see wide utilization, there is a significant need in numerous climate and applied applications for a fused product on a regular grid. Aerosol data assimilation is an operational reality at numerous centers, and like meteorological reanalyses, aerosol reanalyses will see significant use in the near future. Here we present a standardized 2003-2013 global 1° × 1° and 6 hourly modal aerosol optical thickness (AOT) reanalysis product. This dataset can be applied to basic and applied earth system science studies of significant aerosol events, aerosol impacts on numerical weather prediction, and electro-optical propagation and sensor performance, among other uses. This paper describes the science of how to develop and score an aerosol reanalysis product. This reanalysis utilizes a modified Navy Aerosol Analysis and Prediction System (NAAPS) at its core and assimilates quality controlled retrievals of AOT from the Moderate Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua and the Multi-angle Imaging SpectroRadiometer (MISR) on Terra. The aerosol source functions, including dust and smoke, were regionally tuned to obtain the best match between the model fine and coarse mode AOTs and the Aerosol Robotic Network (AERONET) AOTs. Other model processes, including deposition, were tuned to minimize the AOT difference between the model and satellite AOT. Aerosol wet deposition in the tropics is driven with satellite retrieved precipitation, rather than the model field. The final reanalyzed fine and coarse mode AOT at 550 nm is shown to have good agreement with AERONET observations, with global mean root mean square error around 0.1 for both fine and coarse mode AOTs. This paper includes a discussion of issues particular to aerosol reanalyses that make them distinct from standard meteorological reanalyses, considerations for extending such a reanalysis outside of the NASA A-Train era, and examples of how the aerosol reanalysis can be applied or fused with other model or remote sensing products. Finally, the reanalysis is evaluated in comparison with other available studies of aerosol trends, and the implications of this comparison are discussed.

Bioactive natural products from Chinese marine flora and fauna

PubMed Central

Zhou, Zhen-fang; Guo, Yue-wei

2012-01-01

In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail. PMID:22941288

Synthetic Biology and Microbial Fuel Cells: Towards Self-Sustaining Life Support Systems

NASA Technical Reports Server (NTRS)

Hogan, John Andrew

2014-01-01

NASA ARC and the J. Craig Venter Institute (JCVI) collaborated to investigate the development of advanced microbial fuels cells (MFCs) for biological wastewater treatment and electricity production (electrogenesis). Synthetic biology techniques and integrated hardware advances were investigated to increase system efficiency and robustness, with the intent of increasing power self-sufficiency and potential product formation from carbon dioxide. MFCs possess numerous advantages for space missions, including rapid processing, reduced biomass and effective removal of organics, nitrogen and phosphorus. Project efforts include developing space-based MFC concepts, integration analyses, increasing energy efficiency, and investigating novel bioelectrochemical system applications

Aromatic polyketide synthases from 127 Fusarium: pas de deux for chemical diversity

USDA-ARS?s Scientific Manuscript database

Fusarium species collectively cause disease on almost all crop plants and produce numerous natural products (NPs), including mycotoxins, of great concern. Many Fusarium NPs are derived from polyketide synthases (PKSs), large enzymes that catalyze the condensation of simple carboxylic acids. To gain ...

The forest resources of Puerto Rico

Treesearch

Richard A. Birdsey; Peter L. Weaver

1982-01-01

A forest survey conducted in 1980 found 130 thousand hectares of potential commercial timberland and 148 thousand hectares of other forest land. Most of the forest area has regrown on abandoned pasture and cropland including coffee production areas. The timberland areas are composed of numerous species and forest conditions.

Modern Perspectives on Numerical Modeling of Cardiac Pacemaker Cell

PubMed Central

Maltsev, Victor A.; Yaniv, Yael; Maltsev, Anna V.; Stern, Michael D.; Lakatta, Edward G.

2015-01-01

Cardiac pacemaking is a complex phenomenon that is still not completely understood. Together with experimental studies, numerical modeling has been traditionally used to acquire mechanistic insights in this research area. This review summarizes the present state of numerical modeling of the cardiac pacemaker, including approaches to resolve present paradoxes and controversies. Specifically we discuss the requirement for realistic modeling to consider symmetrical importance of both intracellular and cell membrane processes (within a recent “coupled-clock” theory). Promising future developments of the complex pacemaker system models include the introduction of local calcium control, mitochondria function, and biochemical regulation of protein phosphorylation and cAMP production. Modern numerical and theoretical methods such as multi-parameter sensitivity analyses within extended populations of models and bifurcation analyses are also important for the definition of the most realistic parameters that describe a robust, yet simultaneously flexible operation of the coupled-clock pacemaker cell system. The systems approach to exploring cardiac pacemaker function will guide development of new therapies, such as biological pacemakers for treating insufficient cardiac pacemaker function that becomes especially prevalent with advancing age. PMID:24748434

Research-to-operations (R2O) for the Space Environmental Effects Fusion System (SEEFS) system-impact products

NASA Astrophysics Data System (ADS)

Quigley, Stephen

The Space Vehicles Directorate of the Air Force Research Laboratory (AFRL/RVBX) and the Space Environment Branch of the Space and Missile Systems Center (SMC SLG/WMLE) have combined efforts to design, develop, test, implement, and validate numerical and graphical products for Air Force Space Command's (AFSPC) Space Environmental Effects Fusion System (SEEFS). These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense weapons, navigation, communications, and surveillance systems. Jointly developed projects that have been completed as prototypes and are undergoing development for real-time operations include a SEEFS architecture and database, five system-impact products, and a high-level decision aid product. This first round of SEEFS products includes the Solar Radio Burst Effects (SoRBE) on radar and satellite communications, Radar Auroral Clutter (RAC), Scintillation Effects on radar and satellite communications (RadScint and SatScint), and Satellite Surface and Deep Charge/Discharge (Char/D) products. This presentation will provide overviews of the current system impact products, along with plans and potentials for future products expected for the SEEFS program. The overviews will include information on applicable research-to-operations (R2O) issues, to include input data coverage and quality control, output confidence levels, modeling standards, and validation efforts.

Electronic cigarettes: product characterisation and design considerations.

PubMed

Brown, Christopher J; Cheng, James M

2014-05-01

To review the available evidence regarding electronic cigarette (e-cigarette) product characterisation and design features in order to understand their potential impact on individual users and on public health. Systematic literature searches in 10 reference databases were conducted through October 2013. A total of 14 articles and documents and 16 patents were included in this analysis. Numerous disposable and reusable e-cigarette product options exist, representing wide variation in product configuration and component functionality. Common e-cigarette components include an aerosol generator, a flow sensor, a battery and a nicotine-containing solution storage area. e-cigarettes currently include many interchangeable parts, enabling users to modify the character of the delivered aerosol and, therefore, the product's 'effectiveness' as a nicotine delivery product. Materials in e-cigarettes may include metals, rubber and ceramics. Some materials may be aerosolised and have adverse health effects. Several studies have described significant performance variability across and within e-cigarette brands. Patent applications include novel product features designed to influence aerosol properties and e-cigarette efficiency at delivering nicotine. Although e-cigarettes share a basic design, engineering variations and user modifications result in differences in nicotine delivery and potential product risks. e-cigarette aerosols may include harmful and potentially harmful constituents. Battery explosions and the risks of exposure to the e-liquid (especially for children) are also concerns. Additional research will enhance the current understanding of basic e-cigarette design and operation, aerosol production and processing, and functionality. A standardised e-cigarette testing regime should be developed to allow product comparisons.

Bioreactor concepts for cell culture-based viral vaccine production.

PubMed

Gallo-Ramírez, Lilí Esmeralda; Nikolay, Alexander; Genzel, Yvonne; Reichl, Udo

2015-01-01

Vaccine manufacturing processes are designed to meet present and upcoming challenges associated with a growing vaccine market and to include multi-use facilities offering a broad portfolio and faster reaction times in case of pandemics and emerging diseases. The final products, from whole viruses to recombinant viral proteins, are very diverse, making standard process strategies hardly universally applicable. Numerous factors such as cell substrate, virus strain or expression system, medium, cultivation system, cultivation method, and scale need consideration. Reviewing options for efficient and economical production of human vaccines, this paper discusses basic factors relevant for viral antigen production in mammalian cells, avian cells and insect cells. In addition, bioreactor concepts, including static systems, single-use systems, stirred tanks and packed-beds are addressed. On this basis, methods towards process intensification, in particular operational strategies, the use of perfusion systems for high product yields, and steps to establish continuous processes are introduced.

9 CFR 329.9 - Criminal offenses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Criminal offenses. 329.9 Section 329.9... CERTIFICATION DETENTION; SEIZURE AND CONDEMNATION; CRIMINAL OFFENSES § 329.9 Criminal offenses. The Act contains criminal provisions with respect to numerous offenses specified in the Act, including but not limited to...

Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals

USDA-ARS?s Scientific Manuscript database

Numerous endocrine cell subtypes exist within the intestinal mucosa and produce peptides contributing to the regulation of critical physiological processes including appetite, energy metabolism, gut function, and gut health. The mechanisms of action and the extent of the physiological effects of the...

The Stability and Structure of Lean Hydrogen-Air Flames: Effects of Gravity

DTIC Science & Technology

1990-05-17

INTRODUCTION ................................................................................................. 1 MULTIDIMENSIONAL FLAME MODEL ...combustion, molecular diffusion between the reactants, intermediates, and products, thermal conduction, convection, and gravity. Such a detailed model allows...instabil- ity, generally called the Rayleigh-Taylor instability5 . A numerical model of the premixed hydrogen flame that includes all the physical

Transition of genomic evaluation from a research project to a production system

USDA-ARS?s Scientific Manuscript database

Genomic data began to be included in official USDA genetic evaluations of dairy cattle in January 2009. Numerous changes to the evaluation system were made to enable efficient management of genomic information, to incorporate it in official evaluations, and to distribute evaluations. Artificial-inse...

CBES--An Efficient Implementation of the Coursewriter Language.

ERIC Educational Resources Information Center

Franks, Edward W.

An extensive computer based education system (CBES) built around the IBM Coursewriter III program product at Ohio State University is described. In this system, numerous extensions have been added to the Coursewriter III language to provide capabilities needed to implement sophisticated instructional strategies. CBES design goals include lower CPU…

Mexico: The Socio-Economic and Cultural Environment for Health.

ERIC Educational Resources Information Center

Stambler, Moses

Numerous factors influencing health status and health care in Mexico are reviewed in this paper. Part I covers socioeconomic influences including agricultural and land tenure patterns, oil production, population growth rate, and the extent of poverty. Part II discusses the political environment, emphasizing the effects of politics on strategies…

Evaluation of the expression genes associated with resistance to Aspergillus flavus colonization and aflatoxin production in different maize lines.

USDA-ARS?s Scientific Manuscript database

Aflatoxins are carcinogenic toxic compounds produced by Aspergillus flavus during infection of crops including maize (Zea mays L.). Contamination of maize with aflatoxin is exacerbated by late season drought stress. Previous studies have implicated numerous resistance-associated proteins (RAPs) that...

Light, canopy closure, and overstory retention in upland Ozark forests

Treesearch

Elizabeth M. Blizzard; John M. Kabrick; Daniel C. Dey; David R. Larsen; Stephen G. Pallardy; David P. Gwaze

2013-01-01

Foresters, wildlife biologists, and naturalists manipulate forest composition and structure for numerous reasons including forest regeneration, timber production, wildlife habitat, conservation of native biodiversity, and ecosystem restoration. Light conditions in the understory of forests and woodlands are often key in meeting the management objectives. In this study...

Numerical Ergonomics Analysis in Operation Environment of CNC Machine

NASA Astrophysics Data System (ADS)

Wong, S. F.; Yang, Z. X.

2010-05-01

The performance of operator will be affected by different operation environments [1]. Moreover, poor operation environment may cause health problems of the operator [2]. Physical and psychological considerations are two main factors that will affect the performance of operator under different conditions of operation environment. In this paper, applying scientific and systematic methods find out the pivot elements in the field of physical and psychological factors. There are five main factors including light, temperature, noise, air flow and space that are analyzed. A numerical ergonomics model has been built up regarding the analysis results which can support to advance the design of operation environment. Moreover, the output of numerical ergonomic model can provide the safe, comfortable, more productive conditions for the operator.

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application.

PubMed

Kocot, Joanna; Kiełczykowska, Małgorzata; Luchowska-Kocot, Dorota; Kurzepa, Jacek; Musik, Irena

2018-01-01

Honeybees products comprise of numerous substances, including propolis, bee pollen, and royal jelly, which have long been known for their medicinal and health-promoting properties. Their wide biological effects have been known and used since antiquity. Bee products are considered to be a potential source of natural antioxidants such as flavonoids, phenolic acids, or terpenoids. Nowadays, the still growing concern in natural substances capable of counteracting the effects of oxidative stress underlying the pathogenesis of numerous diseases, such as neurodegenerative disorders, cancer, diabetes, and atherosclerosis, as well as negative effects of different harmful factors and drugs, is being observed. Having regarded the importance of acquiring drugs from natural sources, this review is aimed at updating the current state of knowledge of antioxidant capacity of selected bee products, namely, propolis, bee pollen, and royal jelly, and of their potential antioxidant-related therapeutic applications. Moreover, the particular attention has been attributed to the understanding of the mechanisms underlying antioxidant properties of bee products. The influence of bee species, plant origin, geographic location, and seasonality as well as type of extraction solutions on the composition of bee products extracts were also discussed.

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

PubMed Central

Kiełczykowska, Małgorzata; Luchowska-Kocot, Dorota; Kurzepa, Jacek; Musik, Irena

2018-01-01

Honeybees products comprise of numerous substances, including propolis, bee pollen, and royal jelly, which have long been known for their medicinal and health-promoting properties. Their wide biological effects have been known and used since antiquity. Bee products are considered to be a potential source of natural antioxidants such as flavonoids, phenolic acids, or terpenoids. Nowadays, the still growing concern in natural substances capable of counteracting the effects of oxidative stress underlying the pathogenesis of numerous diseases, such as neurodegenerative disorders, cancer, diabetes, and atherosclerosis, as well as negative effects of different harmful factors and drugs, is being observed. Having regarded the importance of acquiring drugs from natural sources, this review is aimed at updating the current state of knowledge of antioxidant capacity of selected bee products, namely, propolis, bee pollen, and royal jelly, and of their potential antioxidant-related therapeutic applications. Moreover, the particular attention has been attributed to the understanding of the mechanisms underlying antioxidant properties of bee products. The influence of bee species, plant origin, geographic location, and seasonality as well as type of extraction solutions on the composition of bee products extracts were also discussed. PMID:29854089

REACTIVE OXYGEN SPECIES: IMPACT ON SKELETAL MUSCLE

PubMed Central

Powers, Scott K.; Ji, Li Li; Kavazis, Andreas N.; Jackson, Malcolm J.

2014-01-01

It is well established that contracting muscles produce both reactive oxygen and nitrogen species. Although the sources of oxidant production during exercise continue to be debated, growing evidence suggests that mitochondria are not the dominant source. Regardless of the sources of oxidants in contracting muscles, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Further, oxidants regulate numerous cell signaling pathways and modulate the expression of many genes. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species result in contractile dysfunction and fatigue. Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox-regulation of muscle adaptation and oxidant-mediated muscle fatigue. PMID:23737208

Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases

PubMed Central

Gul, Waseem; Hamann, Mark T.

2016-01-01

The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities. PMID:16236327

Review: Chios mastic gum: a plant-produced resin exhibiting numerous diverse pharmaceutical and biomedical properties.

PubMed

Dimas, Konstantinos S; Pantazis, Panayotis; Ramanujam, Rama

2012-01-01

Chios mastic gum (CMG) is a resin produced by the plant Pistacia lentiscus var. chia. CMG is used to extract the mastic gum essential oil (MGO). CMG and MGO consist of nearly 70 constituents and have demonstrated numerous and diverse biomedical and pharmacological properties including (a) eradication of bacteria and fungi that may cause peptic ulcers, tooth plaque formation and malodor of the mouth and saliva; (b) amelioration or dramatic reduction of symptoms of autoimmune diseases by inhibiting production of pro-inflammatory substances by activated macrophages, production of cytokines by peripheral blood mononuclear cells in patients with active Crohn's disease, and suppression of production of inflammatory cytokines and chemokines in an asthma model in mice; (c) protection of the cardiovascular system by effectively lowering the levels of total serum cholesterol, low-density lipoprotein and triglycerides in rats, and protection of low-density lipoprotein from oxidation in humans; (d) induction of apoptosis in human cancer cells in vitro and extensive inhibition of growth of human tumors xenografted in immunodeficient mice; and (e) improvement of symptoms in patients with functional dyspepsia. Collectively taken, these numerous and diverse medical and pharmaceutical properties of CMG and MGO warrant further research in an effort to enhance specific properties and identify specific constituent(s) that might be associated with each property.

Numerical Modeling of the Effects of Nutrient-rich Coastal-water Input on the Phytoplankton in the Gulf of California

NASA Astrophysics Data System (ADS)

Bermudez, A.; Rivas, D.

2015-12-01

Phytoplankton bloom dynamics depends on the interactions of favorable physical, chemical, and biotic conditions, particularly on the available nutrients that enhance phytoplankton growth, like nitrogen. Costal and estuarine environments are heavily influenced by exogenous sources of nitrogen; the anthropogenic inputs include urban and rural wastewater coming from agricultural activities (i.e., fertilizers and animal waste). In response, new production is often enhanced, leading eutrophication and phytoplankton blooms, including harmful taxa. These events have become more frequent, and with it the interest to evaluate their effects on marine ecosystems and the impact on human health. In the Gulf of California the harmful algal blooms (HABs) had affected aquaculture, fisheries, and even tourism, thereby it is important to generate information about biological and physical factors that can influence their appearance. A numerical model is a tool that may bring key information about the origin and distribution of phytoplankton blooms. Herein the analysis is based on a three-dimensional, hydrodynamical numerical model, coupled to a Nitrogen-Phytoplankton-Zooplankton-Detritus (NPZD) model. Several numerical simulations using different forcing and scenarios are carried out in order to evaluate the processes that influence the phytoplankton growth. These numerical results are compared to available observations. Thus, the main environmental factors triggering the generation of HABs can be identified.

Proceedings of the IMOG (Interagency Manufacturing Operations Group) Numerical Systems Group. 62nd Meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maes, G.J.

1993-10-01

This document contains the proceedings of the 62nd Interagency Manufacturing Operations Group (IMOG) Numerical Systems Group. Included are the minutes of the 61st meeting and the agenda for the 62nd meeting. Presentations at the meeting are provided in the appendices to this document. Presentations were: 1992 NSG Annual Report to IMOG Steering Committee; Charter for the IMOG Numerical Systems Group; Y-12 Coordinate Measuring Machine Training Project; IBH NC Controller; Automatically Programmed Metrology Update; Certification of Anvil-5000 for Production Use at the Y-12 Plant; Accord Project; Sandia National Laboratories {open_quotes}Accord{close_quotes}; Demo/Anvil Tool Path Generation 5-Axis; Demo/Video Machine/Robot Animation Dynamics; Demo/Certification ofmore » Anvil Tool Path Generation; Tour of the M-60 Inspection Machine; Distributed Numerical Control Certification; Spline Usage Method; Y-12 NC Engineering Status; and Y-12 Manufacturing CAD Systems.« less

Hydrogen production by Cyanobacteria.

PubMed

Dutta, Debajyoti; De, Debojyoti; Chaudhuri, Surabhi; Bhattacharya, Sanjoy K

2005-12-21

The limited fossil fuel prompts the prospecting of various unconventional energy sources to take over the traditional fossil fuel energy source. In this respect the use of hydrogen gas is an attractive alternate source. Attributed by its numerous advantages including those of environmentally clean, efficiency and renew ability, hydrogen gas is considered to be one of the most desired alternate. Cyanobacteria are highly promising microorganism for hydrogen production. In comparison to the traditional ways of hydrogen production (chemical, photoelectrical), Cyanobacterial hydrogen production is commercially viable. This review highlights the basic biology of cynobacterial hydrogen production, strains involved, large-scale hydrogen production and its future prospects. While integrating the existing knowledge and technology, much future improvement and progress is to be done before hydrogen is accepted as a commercial primary energy source.

Numerical Prediction of Chevron Nozzle Noise Reduction using Wind-MGBK Methodology

NASA Technical Reports Server (NTRS)

Engblom, W.A.; Bridges, J.; Khavarant, A.

2005-01-01

Numerical predictions for single-stream chevron nozzle flow performance and farfield noise production are presented. Reynolds Averaged Navier Stokes (RANS) solutions, produced via the WIND flow solver, are provided as input to the MGBK code for prediction of farfield noise distributions. This methodology is applied to a set of sensitivity cases involving varying degrees of chevron inward bend angle relative to the core flow, for both cold and hot exhaust conditions. The sensitivity study results illustrate the effect of increased chevron bend angle and exhaust temperature on enhancement of fine-scale mixing, initiation of core breakdown, nozzle performance, and noise reduction. Direct comparisons with experimental data, including stagnation pressure and temperature rake data, PIV turbulent kinetic energy fields, and 90 degree observer farfield microphone data are provided. Although some deficiencies in the numerical predictions are evident, the correct farfield noise spectra trends are captured by the WIND-MGBK method, including the noise reduction benefit of chevrons. Implications of these results to future chevron design efforts are addressed.

Measurements of the [Formula: see text] production cross sections in association with jets with the ATLAS detector.

PubMed

Aad, G; Abbott, B; Abdallah, J; Abdel Khalek, S; Abdinov, O; Aben, R; Abi, B; Abolins, M; AbouZeid, O S; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Adelman, J; Adomeit, S; Adye, T; Agatonovic-Jovin, T; Aguilar-Saavedra, J A; Agustoni, M; Ahlen, S P; Ahmadov, F; Aielli, G; Akerstedt, H; Åkesson, T P A; Akimoto, G; Akimov, A V; Alberghi, G L; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, B M M; Allison, L J; Allport, P P; Almond, J; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Alvarez Gonzalez, B; Alviggi, M G; Amako, K; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anderson, K J; Andreazza, A; Andrei, V; Anduaga, X S; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, A V; Anjos, N; Annovi, A; Antonaki, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Aperio Bella, L; Apolle, R; Arabidze, G; Aracena, I; Arai, Y; Araque, J P; Arce, A T H; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, A J; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Åsman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, N B; Auerbach, B; Augsten, K; Aurousseau, M; Avolio, G; Azuelos, G; Azuma, Y; Baak, M A; Baas, A E; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Backus Mayes, J; Badescu, E; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, J T; Baker, O K; Balek, P; Balli, F; Banas, E; Banerjee, Sw; Bannoura, A A E; Bansal, V; Bansil, H S; Barak, L; Baranov, S P; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnett, B M; Barnett, R M; Barnovska, Z; Baroncelli, A; Barone, G; Barr, A J; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Bartsch, V; Bassalat, A; Basye, A; Bates, R L; Batley, J R; Battaglia, M; Battistin, M; Bauer, F; Bawa, H S; Beattie, M D; Beau, T; Beauchemin, P H; Beccherle, R; Bechtle, P; Beck, H P; Becker, K; Becker, S; Beckingham, M; Becot, C; Beddall, A J; Beddall, A; Bedikian, S; Bednyakov, V A; Bee, C P; Beemster, L J; Beermann, T A; Begel, M; Behr, K; Belanger-Champagne, C; Bell, P J; Bell, W H; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez Garcia, J A; Benjamin, D P; Bensinger, J R; Benslama, K; Bentvelsen, S; Berge, D; Bergeaas Kuutmann, E; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernat, P; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, M I; Besjes, G J; Bessidskaia Bylund, O; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bhimji, W; Bianchi, R M; Bianchini, L; Bianco, M; Biebel, O; Bieniek, S P; Bierwagen, K; Biesiada, J; Biglietti, M; Bilbao De Mendizabal, J; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Black, C W; Black, J E; Black, K M; Blackburn, D; Blair, R E; Blanchard, J-B; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Bock, C; Boddy, C R; Boehler, M; Boek, T T; Bogaerts, J A; Bogdanchikov, A G; Bogouch, A; Bohm, C; Bohm, J; Boisvert, V; Bold, T; Boldea, V; Boldyrev, A S; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borri, M; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boterenbrood, H; Boudreau, J; Bouffard, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Bousson, N; Boutouil, S; Boveia, A; Boyd, J; Boyko, I R; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Braun, H M; Brazzale, S F; Brelier, B; Brendlinger, K; Brennan, A J; Brenner, R; Bressler, S; Bristow, K; Bristow, T M; Britton, D; Brochu, F M; Brock, I; Brock, R; Bromberg, C; Bronner, J; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Brown, J; Bruckman de Renstrom, P A; Bruncko, D; Bruneliere, R; Brunet, S; Bruni, A; Bruni, G; Bruschi, M; Bryngemark, L; Buanes, T; Buat, Q; Bucci, F; Buchholz, P; Buckingham, R M; Buckley, A G; Buda, S I; Budagov, I A; Buehrer, F; Bugge, L; Bugge, M K; Bulekov, O; Bundock, A C; Burckhart, H; Burdin, S; Burghgrave, B; Burke, S; Burmeister, I; Busato, E; Büscher, D; Büscher, V; Bussey, P; Buszello, C P; Butler, B; Butler, J M; Butt, A I; Buttar, C M; Butterworth, J M; Butti, P; Buttinger, W; Buzatu, A; Byszewski, M; Cabrera Urbán, S; Caforio, D; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Calkins, R; Caloba, L P; Calvet, D; Calvet, S; Camacho Toro, R; Camarda, S; Cameron, D; Caminada, L M; Caminal Armadans, R; Campana, S; Campanelli, M; Campoverde, A; Canale, V; Canepa, A; Cano Bret, M; 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This paper presents cross sections for the production of a [Formula: see text] boson in association with jets, measured in proton-proton collisions at [Formula: see text] with the ATLAS experiment at the large hadron collider. With an integrated luminosity of [Formula: see text], this data set allows for an exploration of a large kinematic range, including jet production up to a transverse momentum of [Formula: see text] and multiplicities up to seven associated jets. The production cross sections for [Formula: see text] bosons are measured in both the electron and muon decay channels. Differential cross sections for many observables are also presented including measurements of the jet observables such as the rapidities and the transverse momenta as well as measurements of event observables such as the scalar sums of the transverse momenta of the jets. The measurements are compared to numerous QCD predictions including next-to-leading-order perturbative calculations, resummation calculations and Monte Carlo generators.

Measurements of the W production cross sections in association with jets with the ATLAS detector

DOE PAGES

Aad, G.

2015-02-19

This paper presents cross sections for the production of a W boson in association with jets, measured in proton–proton collisions at \\(\\sqrt{s} = 7\\) TeV with the ATLAS experiment at the large hadron collider. With an integrated luminosity of 4.6fb -1, this data set allows for an exploration of a large kinematic range, including jet production up to a transverse momentum of 1TeV and multiplicities up to seven associated jets. The production cross sections for W bosons are measured in both the electron and muon decay channels. Differential cross sections for many observables are also presented including measurements of themore » jet observables such as the rapidities and the transverse momenta as well as measurements of event observables such as the scalar sums of the transverse momenta of the jets. As a result, the measurements are compared to numerous QCD predictions including next-to-leading-order perturbative calculations, resummation calculations and Monte Carlo generators.« less

Catalytic Organometallic Reactions of Ammonia

PubMed Central

Klinkenberg, Jessica L.

2012-01-01

Until recently, ammonia had rarely succumbed to catalytic transformations with homogeneous catalysts, and the development of such reactions that are selective for the formation of single products under mild conditions has encountered numerous challenges. However, recently developed catalysts have allowed several classes of reactions to create products with nitrogen-containing functional groups from ammonia. These reactions include hydroaminomethylation, reductive amination, alkylation, allylic substitution, hydroamination, and cross-coupling. This Minireview describes examples of these processes and the factors that control catalyst activity and selectivity. PMID:20857466

Solar Energy Systems

NASA Astrophysics Data System (ADS)

1984-01-01

Calibrated in kilowatt hours per square meter, the solar counter produced by Dodge Products, Inc. provides a numerical count of the solar energy that has accumulated on a surface. Solar energy sensing, measuring and recording devices in corporate solar cell technology developed by Lewis Research Center. Customers for their various devices include architects, engineers and others engaged in construction and operation of solar energy facilities; manufacturers of solar systems or solar related products, such as glare reducing windows; and solar energy planners in federal and state government agencies.

The Production of Present and Absent Presences in Education

ERIC Educational Resources Information Center

Frelin, Anneli; Grannäs, Jan

2013-01-01

Drawing on the distinction between absent and present presences, this article contributes to our understanding of how new managerial and performative discourses are played out in a secondary school context in Sweden. The consequences of numerous educational reforms during the last 20 years include a surge of new independent schools and increased…

When does biodiversity matter? Assessing ecosystem services across broad regions using forest inventory and analysis data

Treesearch

Kevin M. Potter; Christopher W. Woodall; Christopher M. Oswalt; Basil V. III Iannone; Songlin Fei

2015-01-01

Biodiversity is expected to convey numerous functional benefits to forested ecosystems, including increased productivity and resilience. When assessing biodiversity, however, statistics that account for evolutionary relationships among species may be more ecologically meaningful than traditional measures such as species richness. In three broad-scale studies, we...

Fifty years of forest hydrology in the Southeast

Treesearch

C. Rhett Jackson; Ge Sun; Devendra Amatya; Wayne T. Swank; Mark Riedel; Jim Patric; Tom Williams; Jim M. Vose; Carl Trettin; W. Michael Aust; R. Scott Beasley; Hamlin Williston; George G. Ice

2004-01-01

The forests of the southeastern United States are incredibly valuable and diverse, both for timber production and for the aquatic habitat they provide. These overlapping values and diverse conditions have spawned numerous studies to assess how forest management affects hydrology and water quality. In the mountains, key watershed studies include those conducted at USDA...

Development of knowledge and tools to enhance resilience of beef grazing systems for sustainable animal protein production

USDA-ARS?s Scientific Manuscript database

Ruminant livestock provide an important source of meat and dairy protein that sustain the health and livelihoods for much of the world’s population. Grazinglands that support ruminant livestock provide numerous other ecosystem services, including provision of food, water, and genetic resources; regu...

Evaluation of the expression of genes associated with resistance to Aspergillus flavus colonization and aflatoxin production in different maize lines

USDA-ARS?s Scientific Manuscript database

Aflatoxins are carcinogenic toxic compounds produced by Aspergillus flavus during infection of crops including maize (Zea mays L.). Contamination of maize with aflatoxin is exacerbated by late season drought stress. Previous studies have implicated numerous resistance-associated proteins (RAPs) that...

DIESEL EXHAUST PARTICLES SUPRESS LPS-STIMULATED PRODUCTION OF PGE2 IN HUMAN ALVEOLAR MACHROPHAGES: ROLE OF P38 MAPK AND ERK PATHWAYS

EPA Science Inventory

Numerous studies have reported association between exposure to ambient levels of particulate matter (PM) and adverse health effects, which include respiratory and cardiovascular effects. Diesel exhaust particles (DEP) compose a significant fraction of PM in some areas. Alveolar m...

Exploitation of allelopathy for weed control in annual and perennial cropping systems.

PubMed

Putnam, A R; Defrank, J; Barnes, J P

1983-08-01

A variety of crops, cultivars, and accessions have been evaluated over the past six years for superior capability to suppress weed growth. The most successful of these approaches has been to grow cover crops of rye (Secale cereale), wheat (Triticum aestivum), sorghum (Sorghum bicolor), or barley (Hordeum vulgare) to a height of 40-50 cm, desiccate the crops by contact herbicides or freezing, and allow their residues to remain on the soil surface. Often, up to 95% control of important agroecosystem weed species was obtained for a 30- to 60-day period following desiccation of the cover crop. The plant residues on the soil surface exhibit numerous physical and chemical attributes that contribute to weed suppression. Physical aspects include shading and reduced soil temperatures which were similarly achieved using poplar (Populus) excelsior as a control mulch. Chemical aspects apparently include direct release of toxins, as well as production of phytotoxic microbial products. Numerous chemicals appear to work in concert or in an additive or synergistic manner to reduce weed germination and growth.

Off-Highway Heavy Vehicle Diesel Efficiency Improvement and Emissions Reduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jennifer Rumsey

2005-12-31

Cummins Inc. is a world leader in the development and production of diesel engines for on-highway vehicles, off-highway industrial machines, and power generation units. Cummins Inc. diesel products cover a 50-3000 HP range. The power range for this project includes 174-750 HP to achieve EPA's Tier 3 emission levels of 4.0 NOx+NMHC gm/kW-hr and 0.2 PM gm/kWhr and Tier 4 Interim emission levels of 2.0 gm/kW-hr NOx and 0.02 gm/kW-hr PM. Cummins' anticipated product offerings for Tier 4 in this range include the following: QSB6.7, QSC8.3, QSL9, QSM11, QSX15, QSK19. (For reference, numerical values indicate engine displacement in liters, themore » letter designation ns indicate the product model). A summary of the EPA's mobile off-highway emissions requirements is given in Figure 1.« less

Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water.

PubMed

Mompelat, S; Le Bot, B; Thomas, O

2009-07-01

Among all emerging substances in water, pharmaceutical products (PPs) and residues are a lot of concern. These last two years, the number of studies has increased drastically, however much less for water resources and drinking water than for wastewater. This literature review based on recent works, deals with water resources (surface or groundwater), focusing on characteristics, occurrence and fate of numerous PPs studied, and drinking water including water quality. Through this review, it appears that the pharmaceutical risk must be considered even in drinking water where concentrations are very low. Moreover, there is a lack of research for by-products (metabolites and transformation products) characterization, occurrence and fate in all water types and especially in drinking water.

Hydrogen production by Cyanobacteria

PubMed Central

Dutta, Debajyoti; De, Debojyoti; Chaudhuri, Surabhi; Bhattacharya, Sanjoy K

2005-01-01

The limited fossil fuel prompts the prospecting of various unconventional energy sources to take over the traditional fossil fuel energy source. In this respect the use of hydrogen gas is an attractive alternate source. Attributed by its numerous advantages including those of environmentally clean, efficiency and renew ability, hydrogen gas is considered to be one of the most desired alternate. Cyanobacteria are highly promising microorganism for hydrogen production. In comparison to the traditional ways of hydrogen production (chemical, photoelectrical), Cyanobacterial hydrogen production is commercially viable. This review highlights the basic biology of cynobacterial hydrogen production, strains involved, large-scale hydrogen production and its future prospects. While integrating the existing knowledge and technology, much future improvement and progress is to be done before hydrogen is accepted as a commercial primary energy source. PMID:16371161

Regulation of pyruvate metabolism and human disease.

PubMed

Gray, Lawrence R; Tompkins, Sean C; Taylor, Eric B

2014-07-01

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.

The National Heart, Lung, and Blood Institute Small Business Program: A Comprehensive Ecosystem for Biomedical Product Development.

PubMed

Marek, Kurt W

2016-12-01

Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Most small companies that spin out from universities have the scientific knowledge, but product development expertise and business acumen are also needed to be successful. Other challenges include reduced interest in early stage technologies (Pharma & Biotech 2015 in Review, EP Vantage) and limited deal flow for cardiovascular products (Gormley B., Wall Street Journal, September 15, 2014). The NHLBI small business program is a comprehensive ecosystem designed to address these critical challenges and to provide resources and expertise to assist early stage companies developing cardiovascular and other products within the institute's mission. This article describes steps that NHLBI has taken to enhance our small business program to more effectively translate basic discoveries into commercial products to benefit patients and public health, including enhancing internal expertise and developing non-financial resources to assist small businesses as they develop their products and seek private sector investment and partnership.

Thin Gauge Twin-Roll Casting, Process Capabilities and Product Quality

NASA Astrophysics Data System (ADS)

Daaland, O.; Espedal, A. B.; Nedreberg, M. L.; Alvestad, I.

Traditionally industrial twin roll casters have been operated at gauges 6-10 mm, depending on the type of caster and the final product requirements. Over the past few years it has become apparent that a significant increase in productivity can be achieved when the casting gauge is reduced. Hydro Aluminium embarked on an extensive research and development, thin gauge casting programme, in the beginning of the 1990's and this paper presents some results from a five year lasting project (joint programme between Hydro Aluminium a.s. and Lauener Engineering). Based on more than 400 casting trials the major benefits and limitations of casting at reduced gauge and increased speed are outlined. Important aspects related to process development and product quality are discussed including: productivity and limitations, surface defects, microstructural characteristics, cooling rates and dendrite structure, segregation behaviour and mechanical properties after thermo-mechanical processing. Results for casting of several alloys are given. Additionally, numerical modelling results of the strip casting process are included.

Direct cortical stimulation of inferior frontal cortex disrupts both speech and music production in highly trained musicians.

PubMed

Leonard, Matthew K; Desai, Maansi; Hungate, Dylan; Cai, Ruofan; Singhal, Nilika S; Knowlton, Robert C; Chang, Edward F

2018-05-22

Music and speech are human-specific behaviours that share numerous properties, including the fine motor skills required to produce them. Given these similarities, previous work has suggested that music and speech may at least partially share neural substrates. To date, much of this work has focused on perception, and has not investigated the neural basis of production, particularly in trained musicians. Here, we report two rare cases of musicians undergoing neurosurgical procedures, where it was possible to directly stimulate the left hemisphere cortex during speech and piano/guitar music production tasks. We found that stimulation to left inferior frontal cortex, including pars opercularis and ventral pre-central gyrus, caused slowing and arrest for both speech and music, and note sequence errors for music. Stimulation to posterior superior temporal cortex only caused production errors during speech. These results demonstrate partially dissociable networks underlying speech and music production, with a shared substrate in frontal regions.

Making Green Cleaning Easy for Local School Boards

ERIC Educational Resources Information Center

Ashkin, Stephen

2012-01-01

Ten or even five years ago, it would have been a major undertaking for a school district to convert to a comprehensive green cleaning program. At that time there was little precedence and no "roadmaps" for doing so. Thus schools faced numerous challenges that included: (1) what defined a green cleaning product; (2) should a comprehensive program…

Mangroves among the most carbon-rich forests in the tropics

Treesearch

Daniel. C. Donato; J. Boone Kauffman; Daniel Murdiyarso; Sofyan Kurnianto; Melanie Stidham; Markku Kanninen

2011-01-01

Mangrove forests occur along ocean coastlines throughout the tropics, and support numerous ecosystem services, including fisheries production and nutrient cycling. However, the areal extent of mangrove forests has declined by 30–50% over the past half century as a result of coastal development, aquaculture expansion and over-harvesting. Carbon emissions resulting from...

Does biodiversity make a difference? Relationships between species richness, evolutionary diversity, and aboveground live tree biomass across US forests

Treesearch

Kevin M. Potter; Christopher W. Woodall

2014-01-01

Biodiversity conveys numerous functional benefits to forested ecosystems, including community stability and resilience. In the context of managing forests for climate change mitigation/adaptation, maximizing and/or maintaining aboveground biomass will require understanding the interactions between tree biodiversity, site productivity, and the stocking of live trees....

NASA Glenn Research Center Overview

NASA Technical Reports Server (NTRS)

Sehra, Arun K.

2002-01-01

This viewgraph presentation provides information on the NASA Glenn Research Center. The presentation is a broad overview, including the chain of command at the center, its aeronautics facilities, and the factors which shape aerospace product line integration at the center. Special attention is given to the future development of high fidelity probabilistic methods, and NPSS (Numerical Propulsion System Simulation).

Acute toxic nephropathies: clinical pathologic correlations.

PubMed

Muehrcke, R C; Volini, F I; Morris, A M; Moles, J B; Lawrence, A G

1976-01-01

Man's ever increasing exposure to numerous drugs and chemicals, which are the results of medical and industrial progress, produces a by-product of acute toxic nephropathies. These include acute toxic renal failure, drug-induced acute oliguric renal failure, acute hemorrhagic glomerulonephritis, nephrotic syndrome, tubular disturbances and potassium deficiency. In depth information is provided for the previously mentioned disorders.

Integrating LANDIS model and a multi-criteria decision-making approach to evaluate cumulative effects of forest management in the Missouri Ozarks, USA

Treesearch

Zong Bo Shang; Hong S. He; Weimin Xi; Stephen R. Shifley; Brian J. Palik

2012-01-01

Public forest management requires consideration of numerous objectives including protecting ecosystem health, sustaining habitats for native communities, providing sustainable forest products, and providing noncommodity ecosystem services. It is difficult to evaluate the long-term, cumulative effects and tradeoffs these and other associated management objectives. To...

FEWZ 2.0: A code for hadronic Z production at next-to-next-to-leading order

NASA Astrophysics Data System (ADS)

Gavin, Ryan; Li, Ye; Petriello, Frank; Quackenbush, Seth

2011-11-01

We introduce an improved version of the simulation code FEWZ ( Fully Exclusive W and Z Production) for hadron collider production of lepton pairs through the Drell-Yan process at next-to-next-to-leading order (NNLO) in the strong coupling constant. The program is fully differential in the phase space of leptons and additional hadronic radiation. The new version offers users significantly more options for customization. FEWZ now bins multiple, user-selectable histograms during a single run, and produces parton distribution function (PDF) errors automatically. It also features a significantly improved integration routine, and can take advantage of multiple processor cores locally or on the Condor distributed computing system. We illustrate the new features of FEWZ by presenting numerous phenomenological results for LHC physics. We compare NNLO QCD with initial ATLAS and CMS results, and discuss in detail the effects of detector acceptance on the measurement of angular quantities associated with Z-boson production. We address the issue of technical precision in the presence of severe phase-space cuts. Program summaryProgram title: FEWZ Catalogue identifier: AEJP_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJP_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 6 280 771 No. of bytes in distributed program, including test data, etc.: 173 027 645 Distribution format: tar.gz Programming language: Fortran 77, C++, Python Computer: Mac, PC Operating system: Mac OSX, Unix/Linux Has the code been vectorized or parallelized?: Yes. User-selectable, 1 to 219 RAM: 200 Mbytes for common parton distribution functions Classification: 11.1 External routines: CUBA numerical integration library, numerous parton distribution sets (see text); these are provided with the code. Nature of problem: Determination of the Drell-Yan Z/photon production cross section and decay into leptons, with kinematic distributions of leptons and jets including full spin correlations, at next-to-next-to-leading order in the strong coupling constant. Solution method: Virtual loop integrals are decomposed into master integrals using automated techniques. Singularities are extracted from real radiation terms via sector decomposition, which separates singularities and maps onto suitable phase space variables. Result is convoluted with parton distribution functions. Each piece is numerically integrated over phase space, which allows arbitrary cuts on the observed particles. Each sample point may be binned during numerical integration, providing histograms, and reweighted by parton distribution function error eigenvectors, which provides PDF errors. Restrictions: Output does not correspond to unweighted events, and cannot be interfaced with a shower Monte Carlo. Additional comments: !!!!! The distribution file for this program is over 170 Mbytes and therefore is not delivered directly when download or E-mail is requested. Instead a html file giving details of how the program can be obtained is sent. Running time: One day for total cross sections with 0.1% integration errors assuming typical cuts, up to 1 week for smooth kinematic distributions with sub-percent integration errors for each bin.

Regenerating Eye Tissues to Preserve and Restore Vision.

PubMed

Stern, Jeffrey H; Tian, Yangzi; Funderburgh, James; Pellegrini, Graziella; Zhang, Kang; Goldberg, Jeffrey L; Ali, Robin R; Young, Michael; Xie, Yubing; Temple, Sally

2018-06-01

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine. VIDEO ABSTRACT. Copyright © 2018 Elsevier Inc. All rights reserved.

Job Shop Scheduling Focusing on Role of Buffer

NASA Astrophysics Data System (ADS)

Hino, Rei; Kusumi, Tetsuya; Yoo, Jae-Kyu; Shimizu, Yoshiaki

A scheduling problem is formulated in order to consistently manage each manufacturing resource, including machine tools, assembly robots, AGV, storehouses, material shelves, and so on. The manufacturing resources are classified into three types: producer, location, and mover. This paper focuses especially on the role of the buffer, and the differences among these types are analyzed. A unified scheduling formulation is derived from the analytical results based on the resource’s roles. Scheduling procedures based on dispatching rules are also proposed in order to numerically evaluate job shop-type production having finite buffer capacity. The influences of the capacity of bottle-necked production devices and the buffer on productivity are discussed.

Neural underpinnings of divergent production of rules in numerical analogical reasoning.

PubMed

Wu, Xiaofei; Jung, Rex E; Zhang, Hao

2016-05-01

Creativity plays an important role in numerical problem solving. Although the neural underpinnings of creativity have been studied over decades, very little is known about neural mechanisms of the creative process that relates to numerical problem solving. In the present study, we employed a numerical analogical reasoning task with functional Magnetic Resonance Imaging (fMRI) to investigate the neural correlates of divergent production of rules in numerical analogical reasoning. Participants performed two tasks: a multiple solution analogical reasoning task and a single solution analogical reasoning task. Results revealed that divergent production of rules involves significant activations at Brodmann area (BA) 10 in the right middle frontal cortex, BA 40 in the left inferior parietal lobule, and BA 8 in the superior frontal cortex. The results suggest that right BA 10 and left BA 40 are involved in the generation of novel rules, and BA 8 is associated with the inhibition of initial rules in numerical analogical reasoning. The findings shed light on the neural mechanisms of creativity in numerical processing. Copyright © 2016 Elsevier B.V. All rights reserved.

Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression.

PubMed

Yan, Li; Zucker, Stanley; Toole, Bryan P

2005-02-01

Emmprin (basigin;CD147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant tumour cells. Emmprin is involved in numerous physiological and pathological systems and exhibits several molecular and cellular characteristics, but a major function of emmprin is stimulation of synthesis of several matrix metalloproteinases. In tumours, emmprin most likely stimulates matrix metalloproteinase production in stromal fibroblasts and endothelial cells as well as in tumour cells themselves by a mechanism involving homophilic interactions between emmprin molecules on apposing cells or on neighbouring cells after membrane vesicle shedding. Membrane-associated cofactors, including caveolin-1 and annexin II, regulate emmprin activity. Emmprin induces angiogenesis via stimulation of VEGF production, invasiveness via stimulation of matrix metalloproteinase production and multidrug resistance via hyaluronan-mediated up-regulation of ErbB2 signaling and cell survival pathway activities. Although the detailed mechanisms whereby it regulates these numerous phenomena are not yet known, it is clear that emmprin is a major mediator of malignant cell behavior.

A Network of Direct Broadcast Antenna Systems to Provide Real-Time Infrared and Microwave Sounder Data for Numerical Weather Prediction

NASA Astrophysics Data System (ADS)

Gumley, L.

2013-12-01

The Space Science and Engineering Center at the University of Wisconsin-Madison is creating a network of direct broadcast satellite data reception stations to acquire and process infrared and microwave sounder data in real-time from polar orbiting meteorological satellites and deliver the resulting products to NOAA with low latency for assimilation in NCEP numerical weather prediction models. The network will include 4 antenna sites that will be operated directly by SSEC, including Madison WI, Honolulu HI, Miami FL, and Mayaguez PR. The network will also include partner antenna sites not directly controlled by SSEC, including Corvallis OR, Monterey CA, Suitland MD, Fairbanks AK, and Guam. All of the antenna sites will have a combined X/L-band reception system capable of receiving data via direct broadcast from polar orbiting satellites including Suomi NPP and JPSS-1, Metop-A/B, POES,Terra, and Aqua. Each site will collect raw data from these satellites locally, process it to Level 1 (SDR) and Level 2 (EDR) products, and transmit the products back to SSEC for delivery to NOAA/NCEP. The primary purpose of the antenna systems is to provide real-time infrared and microwave sounder data from Metop and Suomi-NPP to NOAA to support data assimilation for NOAA/NCEP operational numerical weather prediction models. At present, NOAA/NCEP use of advanced infrared (CrIS, IASI, AIRS) and microwave (ATMS, AMSU) sounder data over North America in NWP data assimilation is limited because of the latency of the products in relation to the cutoff times for assimilation runs. This network will deliver infrared and microwave sounder data to NCEP with the lowest latency possible, via the reception and processing of data received via direct broadcast. CIMSS/SSEC is managing the procurement and installation of the antenna systems at the two new sites, and will operate the stations remotely. NOAA will establish the reception priorities (Metop and SNPP will be at the highest priority) and SSEC will set the reception schedule to acquire data from these satellites, and any other satellites at lower priority as determined jointly by NOAA, CIMSS/SSEC, and the antenna site hosts. SSEC is providing a product generation server at each site (where applicable) as part of the installed hardware to create satellite products in real-time. The host locations will provide the necessary network resources to enable infrared sounder (CrIS, IASI, and AIRS) and microwave sounder (ATMS and AMSU) data to be sent back to SSEC (and hence to NOAA/NCEP) with low latency (< 15 minutes). This presentation will described how the network realizes the goal of providing data to end users within 15 minutes of observation, and will give examples of the positive impact already observed on NCEP forecast model skill from assimilating real-time infrared and microwave sounder data in the NAM regional domain.

Self-gravitating axially symmetric disks in general-relativistic rotation

NASA Astrophysics Data System (ADS)

Karkowski, Janusz; Kulczycki, Wojciech; Mach, Patryk; Malec, Edward; Odrzywołek, Andrzej; Piróg, Michał

2018-05-01

We integrate numerically axially symmetric stationary Einstein equations describing self-gravitating disks around spinless black holes. The numerical scheme is based on a method developed by Shibata, but contains important new ingredients. We derive a new general-relativistic Keplerian rotation law for self-gravitating disks around spinning black holes. Former results concerning rotation around spinless black holes emerge in the limit of a vanishing spin parameter. These rotation curves might be used for the description of rotating stars, after appropriate modification around the symmetry axis. They can be applied to the description of compact torus-black hole configurations, including active galactic nuclei or products of coalescences of two neutron stars.

Novel molecular markers differentiate Oncorhynchus mykiss (rainbow trout and steelhead) and the O. clarki (cutthroat trout) subspecies

USGS Publications Warehouse

Ostberg, C.O.; Rodriguez, R.J.

2002-01-01

A suite of 26 PCR-based markers was developed that differentiates rainbow (Oncorhynchus mykiss) and coastal cutthroat trout (O. clarki clarki). The markers also differentiated rainbow from other cutthroat trout subspecies (O. clarki), and several of the markers differentiated between cutthroat trout subspecies. This system has numerous positive attributes, including: nonlethal sampling, high species-specificity and products that are easily identified and scored using agarose gel electrophoresis. The methodology described for developing the markers can be applied to virtually any system in which numerous markers are desired for identifying or differentiating species or subspecies.

Power corrections in the N -jettiness subtraction scheme

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boughezal, Radja; Liu, Xiaohui; Petriello, Frank

We discuss the leading-logarithmic power corrections in the N-jettiness subtraction scheme for higher-order perturbative QCD calculations. We compute the next-to-leading order power corrections for an arbitrary N-jet process, and we explicitly calculate the power correction through next-to-next-to-leading order for color-singlet production for bothmore » $$q\\bar{q}$$ and gg initiated processes. Our results are compact and simple to implement numerically. Including the leading power correction in the N-jettiness subtraction scheme substantially improves its numerical efficiency. Finally, we discuss what features of our techniques extend to processes containing final-state jets.« less

Power corrections in the N -jettiness subtraction scheme

DOE PAGES

Boughezal, Radja; Liu, Xiaohui; Petriello, Frank

2017-03-30

We discuss the leading-logarithmic power corrections in the N-jettiness subtraction scheme for higher-order perturbative QCD calculations. We compute the next-to-leading order power corrections for an arbitrary N-jet process, and we explicitly calculate the power correction through next-to-next-to-leading order for color-singlet production for bothmore » $$q\\bar{q}$$ and gg initiated processes. Our results are compact and simple to implement numerically. Including the leading power correction in the N-jettiness subtraction scheme substantially improves its numerical efficiency. Finally, we discuss what features of our techniques extend to processes containing final-state jets.« less

The numerical modelling and process simulation for the fault diagnosis of rotary kiln incinerator.

PubMed

Roh, S D; Kim, S W; Cho, W S

2001-10-01

The numerical modelling and process simulation for the fault diagnosis of rotary kiln incinerator were accomplished. In the numerical modelling, two models applied to the modelling within the kiln are the combustion chamber model including the mass and energy balance equations for two combustion chambers and 3D thermal model. The combustion chamber model predicts temperature within the kiln, flue gas composition, flux and heat of combustion. Using the combustion chamber model and 3D thermal model, the production-rules for the process simulation can be obtained through interrelation analysis between control and operation variables. The process simulation of the kiln is operated with the production-rules for automatic operation. The process simulation aims to provide fundamental solutions to the problems in incineration process by introducing an online expert control system to provide an integrity in process control and management. Knowledge-based expert control systems use symbolic logic and heuristic rules to find solutions for various types of problems. It was implemented to be a hybrid intelligent expert control system by mutually connecting with the process control systems which has the capability of process diagnosis, analysis and control.

FY17Q4 Ristra project: Release Version 1.0 of a production toolkit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hungerford, Aimee L.; Daniel, David John

2017-09-21

The Next Generation Code project will release Version 1.0 of a production toolkit for multi-physics application development on advanced architectures. Features of this toolkit will include remap and link utilities, control and state manager, setup, visualization and I/O, as well as support for a variety of mesh and particle data representations. Numerical physics packages that operate atop this foundational toolkit will be employed in a multi-physics demonstration problem and released to the community along with results from the demonstration.

Precise QCD Predictions for the Production of a Z Boson in Association with a Hadronic Jet.

PubMed

Gehrmann-De Ridder, A; Gehrmann, T; Glover, E W N; Huss, A; Morgan, T A

2016-07-08

We compute the cross section and differential distributions for the production of a Z boson in association with a hadronic jet to next-to-next-to-leading order (NNLO) in perturbative QCD, including the leptonic decay of the Z boson. We present numerical results for the transverse momentum and rapidity distributions of both the Z boson and the associated jet at the LHC. We find that the NNLO corrections increase the NLO predictions by approximately 1% and significantly reduce the scale variation uncertainty.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dulat, Falko; Lionetti, Simone; Mistlberger, Bernhard

We present an analytic computation of the Higgs production cross section in the gluon fusion channel, which is differential in the components of the Higgs momentum and inclusive in the associated partonic radiation through NNLO in perturbative QCD. Our computation includes the necessary higher order terms in the dimensional regulator beyond the finite part that are required for renormalisation and collinear factorisation at N 3LO. We outline in detail the computational methods which we employ. We present numerical predictions for realistic final state observables, specifically distributions for the decay products of the Higgs boson in the γγ decay channel.

Evaluation of an operational water cycle prediction system for the Laurentian Great Lakes and St. Lawrence River

NASA Astrophysics Data System (ADS)

Fortin, Vincent; Durnford, Dorothy; Smith, Gregory; Dyck, Sarah; Martinez, Yosvany; Mackay, Murray; Winter, Barbara

2017-04-01

Environment and Climate Change Canada (ECCC) is implementing new numerical guidance products based on fully coupled numerical models to better inform the public as well as specialized users on the current and future state of various components of the water cycle, including stream flow and water levels. Outputs from this new system, named the Water Cycle Prediction System (WCPS), have been available for the Great Lakes and St. Lawrence River watershed since June 2016. WCPS links together ECCC's weather forecasting model, GEM, the 2-D ice model C-ICE, the 3-D lake and ocean model NEMO, and a 2-D hydrological model, WATROUTE. Information concerning the water cycle is passed between the models at intervals varying from a few minutes to one hour. It currently produces two forecasts per day for the next three days of the complete water cycle in the Great Lakes region, the largest freshwater lake system in the world. Products include spatially-varying precipitation, evaporation, river discharge, water level anomalies, surface water temperatures, ice coverage, and surface currents. These new products are of interest to water resources and management authority, flood forecasters, hydroelectricity producers, navigation, environmental disaster managers, search and rescue teams, agriculture, and the general public. This presentation focuses on the evaluation of various elements forecasted by the system, and weighs the advantages and disadvantages of running the system fully coupled.

Optimal Information Processing in Biochemical Networks

NASA Astrophysics Data System (ADS)

Wiggins, Chris

2012-02-01

A variety of experimental results over the past decades provide examples of near-optimal information processing in biological networks, including in biochemical and transcriptional regulatory networks. Computing information-theoretic quantities requires first choosing or computing the joint probability distribution describing multiple nodes in such a network --- for example, representing the probability distribution of finding an integer copy number of each of two interacting reactants or gene products while respecting the `intrinsic' small copy number noise constraining information transmission at the scale of the cell. I'll given an overview of some recent analytic and numerical work facilitating calculation of such joint distributions and the associated information, which in turn makes possible numerical optimization of information flow in models of noisy regulatory and biochemical networks. Illustrating cases include quantification of form-function relations, ideal design of regulatory cascades, and response to oscillatory driving.

Use of edible coatings to preserve quality of lightly (and slightly) processed products.

PubMed

Baldwin, E A; Nisperos-Carriedo, M O; Baker, R A

1995-11-01

Lightly processed agricultural products present a special problem to the food industry and to scientists involved in postharvest and food technology research. Light or minimal processing includes cutting, slicing, coring, peeling, trimming, or sectioning of agricultural produce. These products have an active metabolism that can result in deteriorative changes, such as increased respiration and ethylene production. If not controlled, these changes can lead to rapid senescence and general deterioration of the product. In addition, the surface water activity of cut fruits and vegetables is generally quite high, inviting microbial attack, which further reduces product stability. Methods for control of these changes are numerous and can include the use of edible coatings. Also mentioned in this review are coating of nut products, and dried, dehydrated, and freeze-dried fruits. Technically, these are not considered to be minimally processed, but many of the problems and benefits of coating these products are similar to coating lightly processed products. Generally, the potential benefits of edible coatings for processed or lightly processed produce is to stabilize the product and thereby extend product shelf life. More specifically, coatings have the potential to reduce moisture loss, restrict oxygen entrance, lower respiration, retard ethylene production, seal in flavor volatiles, and carry additives that retard discoloration and microbial growth.

Research Progress in Reversal of Tumor Multi-drug Resistance via Natural Products.

PubMed

Guo, Qi; Cao, Hongyan; Qi, Xianghui; Li, Huikai; Ye, Peizhi; Wang, Zhiguo; Wang, Danqiao; Sun, Mingyu

2017-11-24

Multidrug resistance occurs when a tumor develops resistance to multiple chemotherapeutic drugs, which may include antitumor drugs with different chemical structures and mechanisms. Multidrug resistance limits the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug resistance is caused by numerous factors including changes in ATP-binding cassette transporters, target proteins, detoxification, deoxyribonucleic acid repair, drug metabolic enzymes, and signal pathways of apoptosis. Clinical research indicates that natural products have great potential to treat tumors and reverse multidrug resistance. Natural products, which often have multiple targets, could play an important role in tumor treatment, have beneficial effects on tumor inhibition, improve symptoms, reduce radiotherapy and chemotherapy side effects, enhance immunity, and prolong survival. Because natural products often have few adverse reactions and less drug resistance, the antitumor activities of natural products have attracted extensive research. We aimed to review the basic research and clinical application of natural products in the reversal of multidrug resistance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The National Heart, Lung, and Blood Institute Small Business Program

PubMed Central

Marek, Kurt W.

2016-01-01

SUMMARY Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Most small companies that spin out from universities have the scientific knowledge, but product development expertise and business acumen are also needed to be successful. Other challenges include reduced interest in early stage technologies (Pharma & Biotech 2015 in Review, EP Vantage) and limited deal flow for cardiovascular products (Gormley B., Wall Street Journal, September 15, 2014). The NHLBI small business program is a comprehensive ecosystem designed to address these critical challenges and to provide resources and expertise to assist early stage companies developing cardiovascular and other products within the institute’s mission. This article describes steps that NHLBI has taken to enhance our small business program to more effectively translate basic discoveries into commercial products to benefit patients and public health, including enhancing internal expertise and developing non-financial resources to assist small businesses as they develop their products and seek private sector investment and partnership. PMID:28580435

Thermal Hydraulic Computational Fluid Dynamics Simulations and Experimental Investigation of Deformed Fuel Assemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mays, Brian; Jackson, R. Brian

2017-03-08

The project, Toward a Longer Life Core: Thermal Hydraulic CFD Simulations and Experimental Investigation of Deformed Fuel Assemblies, DOE Project code DE-NE0008321, was a verification and validation project for flow and heat transfer through wire wrapped simulated liquid metal fuel assemblies that included both experiments and computational fluid dynamics simulations of those experiments. This project was a two year collaboration between AREVA, TerraPower, Argonne National Laboratory and Texas A&M University. Experiments were performed by AREVA and Texas A&M University. Numerical simulations of these experiments were performed by TerraPower and Argonne National Lab. Project management was performed by AREVA Federal Services.more » The first of a kind project resulted in the production of both local point temperature measurements and local flow mixing experiment data paired with numerical simulation benchmarking of the experiments. The project experiments included the largest wire-wrapped pin assembly Mass Index of Refraction (MIR) experiment in the world, the first known wire-wrapped assembly experiment with deformed duct geometries and the largest numerical simulations ever produced for wire-wrapped bundles.« less

The calculating brain: an fMRI study.

PubMed

Rickard, T C; Romero, S G; Basso, G; Wharton, C; Flitman, S; Grafman, J

2000-01-01

To explore brain areas involved in basic numerical computation, functional magnetic imaging (fMRI) scanning was performed on college students during performance of three tasks; simple arithmetic, numerical magnitude judgment, and a perceptual-motor control task. For the arithmetic relative to the other tasks, results for all eight subjects revealed bilateral activation in Brodmann's area 44, in dorsolateral prefrontal cortex (areas 9 and 10), in inferior and superior parietal areas, and in lingual and fusiform gyri. Activation was stronger on the left for all subjects, but only at Brodmann's area 44 and the parietal cortices. No activation was observed in the arithmetic task in several other areas previously implicated for arithmetic, including the angular and supramarginal gyri and the basal ganglia. In fact, angular and supramarginal gyri were significantly deactivated by the verification task relative to both the magnitude judgment and control tasks for every subject. Areas activated by the magnitude task relative to the control were more variable, but in five subjects included bilateral inferior parietal cortex. These results confirm some existing hypotheses regarding the neural basis of numerical processes, invite revision of others, and suggest productive lines for future investigation.

Vulnerability of grazing and confined livestock in the Northern Great Plains to projected mid- and late-twenty-first century climate

Treesearch

Justin Derner; David Briske; Matt Reeves; Tami Brown-Brandl; Miranda Meehan; Dana Blumenthal; William Travis; David Augustine; Hailey Wilmer; Derek Scasta; John Hendrickson; Jerry Volesky; Laura Edwards; Dannele Peck

2017-01-01

The Northern Great Plains (NGP) region of the USA - which comprises Montana, Wyoming, Colorado, North Dakota, South Dakota, and Nebraska - is a largely rural area that provides numerous ecosystem services, including livestock products, cultural services, and conservation of biological diversity. The region contains 25% of the Nation's beef cattle and approximately...

National forest economic clusters: a new model for assessing national-forest-based natural resources products and services.

Treesearch

Thomas D. Rojas

2007-01-01

National forest lands encompass numerous rural and urban communities. Some national-forest-based communities lie embedded within national forests, and others reside just outside the official boundaries of national forests. The urban and rural communities within or near national forest lands include a wide variety of historical traditions and cultural values that affect...

Research Reporting Sections, Annual Meeting of the National Council of Teachers of Mathematics (59th, St. Louis, Missouri, April 22-25, 1981).

ERIC Educational Resources Information Center

Higgins, Jon L., Ed.

Presented are abstracts of 18 research reports. Topics covered include: (1) The effect of a numeration learning hierarchy on mathematics attitudes in kindergarten children; (2) Children's acquisition and production of mathematical rules; (3) Preschoolers' abilities to recognize counting errors; (4) Young children's solution processes for verbal…

No correlation between the diversity and productivity of assemblages: evidence from the phytophage and predator assemblages in various cotton agroecosystems.

PubMed

Gao, Feng; Men, XingYuan; Ge, Feng

2014-09-01

Biodiversity research has shown that primary productivity increases with plant species number, especially in many experimental grassland systems. Here, we assessed the correlation between productivity and diversity of phytophages and natural enemy assemblages associated with planting date and intercropping in four cotton agroecosystems. Twenty-one pairs of data were used to determine Pearson correlations between species richness, total number of individuals, diversity indices and productivity for each assemblage every five days from 5 June to 15 September 2012. At the same trophic level, the productivity exhibited a significant positive correlation with species richness of the phytophage or predator assemblage. A significant correlation was found between productivity and total number of individuals in most cotton fields. However, no significant correlations were observed between productivity and diversity indices (including indices of energy flow diversity and numerical diversity) in most cotton fields for either the phytophage or the predator assemblages. Species richness of phytophage assemblage and total individual numbers were significantly correlated with primary productivity. Also, species richness of natural enemy assemblage and total number of individuals correlated with phytophage assemblage productivity. A negative but not significant correlation occurred between the indices of numerical diversity and energy flow diversity and lower trophic-level productivity in the cotton-phytophage and phytophage-predator assemblages for most intercropped cotton agroecosystems. Our results clearly showed that there were no correlations between diversity indices and productivity within the same or lower trophic levels within the phytophage and predator assemblages in cotton agroecosystems, and inter-cropped cotton fields had a stronger ability to support the natural enemy assemblage and potentially to reduce phytophages.

Production and quality assurance automation in the Goddard Space Flight Center Flight Dynamics Facility

NASA Technical Reports Server (NTRS)

Chapman, K. B.; Cox, C. M.; Thomas, C. W.; Cuevas, O. O.; Beckman, R. M.

1994-01-01

The Flight Dynamics Facility (FDF) at the NASA Goddard Space Flight Center (GSFC) generates numerous products for NASA-supported spacecraft, including the Tracking and Data Relay Satellites (TDRS's), the Hubble Space Telescope (HST), the Extreme Ultraviolet Explorer (EUVE), and the space shuttle. These products include orbit determination data, acquisition data, event scheduling data, and attitude data. In most cases, product generation involves repetitive execution of many programs. The increasing number of missions supported by the FDF has necessitated the use of automated systems to schedule, execute, and quality assure these products. This automation allows the delivery of accurate products in a timely and cost-efficient manner. To be effective, these systems must automate as many repetitive operations as possible and must be flexible enough to meet changing support requirements. The FDF Orbit Determination Task (ODT) has implemented several systems that automate product generation and quality assurance (QA). These systems include the Orbit Production Automation System (OPAS), the New Enhanced Operations Log (NEOLOG), and the Quality Assurance Automation Software (QA Tool). Implementation of these systems has resulted in a significant reduction in required manpower, elimination of shift work and most weekend support, and improved support quality, while incurring minimal development cost. This paper will present an overview of the concepts used and experiences gained from the implementation of these automation systems.

NADPH-generating systems in bacteria and archaea

PubMed Central

Spaans, Sebastiaan K.; Weusthuis, Ruud A.; van der Oost, John; Kengen, Servé W. M.

2015-01-01

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms. It provides the reducing power that drives numerous anabolic reactions, including those responsible for the biosynthesis of all major cell components and many products in biotechnology. The efficient synthesis of many of these products, however, is limited by the rate of NADPH regeneration. Hence, a thorough understanding of the reactions involved in the generation of NADPH is required to increase its turnover through rational strain improvement. Traditionally, the main engineering targets for increasing NADPH availability have included the dehydrogenase reactions of the oxidative pentose phosphate pathway and the isocitrate dehydrogenase step of the tricarboxylic acid (TCA) cycle. However, the importance of alternative NADPH-generating reactions has recently become evident. In the current review, the major canonical and non-canonical reactions involved in the production and regeneration of NADPH in prokaryotes are described, and their key enzymes are discussed. In addition, an overview of how different enzymes have been applied to increase NADPH availability and thereby enhance productivity is provided. PMID:26284036

Polystyrene Foam Products Equation of State as a Function of Porosity and Fill Gas

NASA Astrophysics Data System (ADS)

Mulford, R. N.; Swift, D. C.

2009-12-01

An accurate EOS for polystyrene foam is necessary for analysis of numerous experiments in shock compression, inertial confinement fusion, and astrophysics. Plastic to gas ratios vary between various samples of foam, according to the density and cell-size of the foam. A matrix of compositions has been investigated, allowing prediction of foam response as a function of the plastic-to-air ratio. The EOS code CHEETAH allows participation of the air in the decomposition reaction of the foam. Differences between air-filled, Ar-blown, and CO2-blown foams are investigated, to estimate the importance of allowing air to react with products of polystyrene decomposition. O2-blown foams are included in some comparisons, to amplify any consequences of reaction with oxygen in air. He-blown foams are included in some comparisons, to provide an extremum of density. Product pressures are slightly higher for oxygen-containing fill gases than for non-oxygen-containing fill gases. Examination of product species indicates that CO2 decomposes at high temperatures.

Emerging biopharmaceuticals from marine actinobacteria.

PubMed

Hassan, Syed Shams Ul; Anjum, Komal; Abbas, Syed Qamar; Akhter, Najeeb; Shagufta, Bibi Ibtesam; Shah, Sayed Asmat Ali; Tasneem, Umber

2017-01-01

Actinobacteria are quotidian microorganisms in the marine world, playing a crucial ecological role in the recycling of refractory biomaterials and producing novel secondary metabolites with pharmaceutical applications. Actinobacteria have been isolated from the huge area of marine organisms including sponges, tunicates, corals, mollusks, crabs, mangroves and seaweeds. Natural products investigation of the marine actinobacteria revealed that they can synthesize numerous natural products including alkaloids, polyketides, peptides, isoprenoids, phenazines, sterols, and others. These natural products have a potential to provide future drugs against crucial diseases like cancer, HIV, microbial and protozoal infections and severe inflammations. Therefore, marine actinobacteria portray as a pivotal resource for marine drugs. It is an upcoming field of research to probe a novel and pharmaceutically important secondary metabolites from marine actinobacteria. In this review, we attempt to summarize the present knowledge on the diversity, chemistry and mechanism of action of marine actinobacteria-derived secondary metabolites from 2007 to 2016. Copyright © 2016 Elsevier B.V. All rights reserved.

A New Numerical Simulation technology of Multistage Fracturing in Horizontal Well

NASA Astrophysics Data System (ADS)

Cheng, Ning; Kang, Kaifeng; Li, Jianming; Liu, Tao; Ding, Kun

2017-11-01

Horizontal multi-stage fracturing is recognized the effective development technology of unconventional oil resources. Geological mechanics in the numerical simulation of hydraulic fracturing technology occupies very important position, compared with the conventional numerical simulation technology, because of considering the influence of geological mechanics. New numerical simulation of hydraulic fracturing can more effectively optimize the design of fracturing and evaluate the production after fracturing. This paper studies is based on the three-dimensional stress and rock physics parameters model, using the latest fluid-solid coupling numerical simulation technology to engrave the extension process of fracture and describes the change of stress field in fracturing process, finally predict the production situation.

Physical Science Informatics: Providing Open Science Access to Microheater Array Boiling Experiment Data

NASA Technical Reports Server (NTRS)

McQuillen, John; Green, Robert D.; Henrie, Ben; Miller, Teresa; Chiaramonte, Fran

2014-01-01

The Physical Science Informatics (PSI) system is the next step in this an effort to make NASA sponsored flight data available to the scientific and engineering community, along with the general public. The experimental data, from six overall disciplines, Combustion Science, Fluid Physics, Complex Fluids, Fundamental Physics, and Materials Science, will present some unique challenges. Besides data in textual or numerical format, large portions of both the raw and analyzed data for many of these experiments are digital images and video, requiring large data storage requirements. In addition, the accessible data will include experiment design and engineering data (including applicable drawings), any analytical or numerical models, publications, reports, and patents, and any commercial products developed as a result of the research. This objective of paper includes the following: Present the preliminary layout (Figure 2) of MABE data within the PSI database. Obtain feedback on the layout. Present the procedure to obtain access to this database.

Numerical Study on Deflection Behaviour of Concrete Beams Reinforced with GFRP Bars

NASA Astrophysics Data System (ADS)

Mohamed, Osama A.; Khattab, Rania; Hawat, Waddah Al

2017-10-01

Fiber-Reinforced Polymer (FRP) bars are gaining popularity as sustainable alternatives to conventional reinforcing steel bars in reinforced concrete applications. The production of FRP bars has lower environmental impact compared to steel reinforcing bars. In addition, the non-corroding FRP materials can potentially decrease the cost or need for maintenance of reinforced concrete structural elements, especially in harsh environmental conditions that can impact both concrete and reinforcement. FRP bars offer additional favourable properties including high tensile strength and low unit weight. However, the mechanical properties of FRP bars can lead to large crack widths and deflections. The objective of this study is to investigate the deflection behaviour of concrete beams reinforced with Glass FRP (GFRP) bars as a longitudinal main reinforcement. Six concrete beams reinforced with GFRP bars were modelled using the finite element computer program ANSYS. The main variable considered in the study is the reinforcement ratio. The deflection equations in current North American codes including ACI 440.1R-06, ACI 440.1R-15 and CSA S806-12 are used to compute deflections, and these are compared to numerical results. It was concluded in this paper that deflections predicted by ACI 440.1R-06 equations are lower than the numerical analysis results while ACI 440.1R-15 is in agreement with numerical analysis with tendency to be conservative. The values of deflections estimated by CSA S806-12 formulas are consistent with results of numerical analysis.

Applications for Near-Real Time Satellite Cloud and Radiation Products

NASA Technical Reports Server (NTRS)

Minnis, Patrick; Palikonda, Rabindra; Chee, Thad L.; Bedka, Kristopher M.; Smith, W.; Ayers, Jeffrey K.; Benjamin, Stanley; Chang, F.-L.; Nguyen, Louis; Norris, Peter;

Retailer Stackelberg game in a supply chain with pricing and service decisions and simple price discount contract.

PubMed

Sadjadi, Seyed Jafar; Asadi, Hashem; Sadeghian, Ramin; Sahebi, Hadi

2018-01-01

This paper studies the Retailer Stackelberg game in a supply chain consisting of two manufacturers and one retailer where they compete simultaneously under three factors including price, service and simple price discount contract. It is assumed that the second manufacturer provides service directly to his customers, and the retailer provides service for the first product's customers, while the retailer buys the first product under price discount from the first manufacturer. The analysis of the optimal equilibrium solutions and the results of the numerical examples show that if a manufacturer chooses the appropriate range of discount rate, he will gain more profit than when there is no discount given to the retailer. This situation can be considered as an effective tool for the coordination of the first manufacturer and the retailer to offer discount by manufacturer and to provide the service by the retailer. We obtain equilibrium solution of Retailer Stackelberg game and analyze the numerical examples under two cases: a) the manufacturers sell their products to the retailer without price discount contract. b) The first manufacturer sells his products to the retailer with the simple price discount contract. The preliminary results show that the service and the price discount contract can improve the performance of supply chain.

Turbulent solutions of equations of fluid motion

NASA Technical Reports Server (NTRS)

Deissler, R. G.

1985-01-01

Some turbulent solutions of the unaveraged Navier-Stokes equations (equations of fluid motion) are reviewed. Those equations are solved numerically in order to study the nonlinear physics of incompressible turbulent flow. The three components of the mean-square velocity fluctuations are initially equal for the conditions chosen. The resulting solutions show characteristics of turbulence, such as the linear and nonlinear excitation of small-scale fluctuations. For the stronger fluctuations the initially nonrandom flow develops into an apparently random turbulence. The cases considered include turbulence that is statistically homogeneous or inhomogeneous and isotropic or anisotropic. A statistically steady-state turbulence is obtained by using a spatially periodic body force. Various turbulence processes, including the transfer of energy between eddy sizes and between directional components and the production, dissipation, and spatial diffusion of turbulence, are considered. It is concluded that the physical processes occurring in turbulence can be profitably studied numerically.

Three Years of Global Positioning System Experience on International Space Station

NASA Technical Reports Server (NTRS)

Gomez, Susan

2006-01-01

The International Space Station global positioning system (GPS) receiver was activated in April 2002. Since that time, numerous software anomalies surfaced that had to be worked around. Some of the software problems required waivers, such as the time function, while others required extensive operator intervention, such as numerous power cycles. Eventually enough anomalies surfaced that the three pieces of code included in the GPS unit have been re-written and the GPS units upgraded. The technical aspects of the problems are discussed, as well as the underlying causes that led to the delivery of a product that has had so many problems. The technical aspects of the problems included physical phenomena that were not well understood, such as the affect that the ionosphere would have on the GPS measurements. The underlying causes were traced to inappropriate use of legacy software, changing requirements, inadequate software processes, unrealistic schedules, incorrect contract type, and unclear ownership responsibilities..

Numerical Simulation of Liquid Jet Atomization Including Turbulence Effects

NASA Technical Reports Server (NTRS)

Trinh, Huu P.; Chen, C. P.; Balasubramanyam, M. S.

2005-01-01

This paper describes numerical implementation of a newly developed hybrid model, T-blob/T-TAB, into an existing computational fluid dynamics (CFD) program for primary and secondary breakup simulation of liquid jet atomization. This model extend two widely used models, the Kelvin-Helmholtz (KH) instability of Reitz (blob model) and the Taylor-Analogy-Breakup (TAB) secondary droplet breakup by O'Rourke and Amsden to include turbulence effects. In the primary breakup model, the level of the turbulence effect on the liquid breakup depends on the characteristic scales and the initial flow conditions. For the secondary breakup, an additional turbulence force acted on parent drops is modeled and integrated into the TAB governing equation. Several assessment studies are presented and the results indicate that the existing KH and TAB models tend to under-predict the product drop size and spray angle, while the current model provides superior results when compared with the measured data.

Lunar and Planetary Science XXXV: Meteorites to and from the Moon and Mars: My Planet or Yours?

NASA Technical Reports Server (NTRS)

2004-01-01

The titles in this section include: 1) Meteorites from Mars - Constraints from Numerical Modeling; 2) Iron Oxidation Products in Martian Ordinary Chondrite Finds as Possible Indicators of Liquid Water Exposure at Mars Exploration Rover Landings Sites; 3) Meteorites on Mars; 4) Sulfide Stability of Planetary Basalts; 5) Exposure and Terrestrial Histories of New Lunar and Martian Meteorites.

Project LEAP: The Labor Education Achievement Program. A Program To Improve the Literacy Level and Productivity of the Workforce. Final Project Report. April 1, 1991-September 30, 1992.

ERIC Educational Resources Information Center

Metropolitan Baltimore Council of AFL-CIO Unions, MD.

Maryland's Labor Education Achievement Program (LEAP) worked with a wide diversity of union workers in multiple industries and within numerous private companies and public agencies over a dispersed geographic area. Staff development included a workshop for local coordinators and a teacher inservice training session. LEAP provided…

A failure recovery planning prototype for Space Station Freedom

NASA Technical Reports Server (NTRS)

Hammen, David G.; Kelly, Christine M.

1991-01-01

NASA is investigating the use of advanced automation to enhance crew productivity for Space Station Freedom in numerous areas, including failure management. A prototype is described that uses various advanced automation techniques to generate courses of action whose intents are to recover from a diagnosed failure, and to do so within the constraints levied by the failure and by Freedom's configuration and operating conditions.

Influence of light on the biosynthesis of ophiobolin A by Bipolaris maydis.

PubMed

Fanelli, Francesca; Reveglia, Pierluigi; Masi, Marco; Mulè, Giuseppina; Zonno, Maria Chiara; Cimmino, Alessio; Vurro, Maurizio; Evidente, Antonio

2017-04-01

Ophiobolin A (O-A) is a sesterpenoid with numerous biological activities, including potential anticancer effects. Its production at an industrial level is hampered due to inability of fungus Bipolaris maydis to biosynthesise it in vitro in large amount. Among the environmental factors regulating fungal metabolism, light plays a crucial role. In this study, the use of different light wavelength (light emitting diodes (LEDs)) was evaluated to increase the O-A production. The white light allowed the highest production of the metabolite. The blue and green lights showed an inhibitory effect, reducing the production to 50%, as well as red and yellow but at a lower level. No correlation between fungal growth and metabolite production was found in relation to the light type. A novel application of LED technologies, which can be optimised to foster specific pathways and promote the production of metabolites having scientific and industrial interest was proposed.

Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential.

PubMed

Ruocco, Nadia; Costantini, Susan; Guariniello, Stefano; Costantini, Maria

2016-04-27

Carbohydrates, also called saccharides, are molecules composed of carbon, hydrogen, and oxygen. They are the most abundant biomolecules and essential components of many natural products and have attracted the attention of researchers because of their numerous human health benefits. Among carbohydrates the polysaccharides represent some of the most abundant bioactive substances in marine organisms. In fact, many marine macro- and microorganisms are good resources of carbohydrates with diverse applications due to their biofunctional properties. By acting on cell proliferation and cycle, and by modulating different metabolic pathways, marine polysaccharides (including mainly chitin, chitosan, fucoidan, carrageenan and alginate) also have numerous pharmaceutical activities, such as antioxidative, antibacterial, antiviral, immuno-stimulatory, anticoagulant and anticancer effects. Moreover, these polysaccharides have many general beneficial effects for human health, and have therefore been developed into potential cosmeceuticals and nutraceuticals. In this review we describe current advances in the development of marine polysaccharides for nutraceutical, cosmeceutical and pharmacological applications. Research in this field is opening new doors for harnessing the potential of marine natural products.

The Quantal Larynx: The Stable Regions of Laryngeal Biomechanics and Implications for Speech Production.

PubMed

Moisik, Scott Reid; Gick, Bryan

2017-03-01

Recent proposals suggest that (a) the high dimensionality of speech motor control may be reduced via modular neuromuscular organization that takes advantage of intrinsic biomechanical regions of stability and (b) computational modeling provides a means to study whether and how such modularization works. In this study, the focus is on the larynx, a structure that is fundamental to speech production because of its role in phonation and numerous articulatory functions. A 3-dimensional model of the larynx was created using the ArtiSynth platform (http://www.artisynth.org). This model was used to simulate laryngeal articulatory states, including inspiration, glottal fricative, modal prephonation, plain glottal stop, vocal-ventricular stop, and aryepiglotto-epiglottal stop and fricative. Speech-relevant laryngeal biomechanics is rich with "quantal" or highly stable regions within muscle activation space. Quantal laryngeal biomechanics complement a modular view of speech control and have implications for the articulatory-biomechanical grounding of numerous phonetic and phonological phenomena.

Higgs-differential cross section at NNLO in dimensional regularisation

DOE PAGES

Dulat, Falko; Lionetti, Simone; Mistlberger, Bernhard; ...

2017-07-05

We present an analytic computation of the Higgs production cross section in the gluon fusion channel, which is differential in the components of the Higgs momentum and inclusive in the associated partonic radiation through NNLO in perturbative QCD. Our computation includes the necessary higher order terms in the dimensional regulator beyond the finite part that are required for renormalisation and collinear factorisation at N 3LO. We outline in detail the computational methods which we employ. We present numerical predictions for realistic final state observables, specifically distributions for the decay products of the Higgs boson in the γγ decay channel.

Associated Higgs-W-boson production at hadron colliders: a fully exclusive QCD calculation at NNLO.

PubMed

Ferrera, Giancarlo; Grazzini, Massimiliano; Tramontano, Francesco

2011-10-07

We consider QCD radiative corrections to standard model Higgs-boson production in association with a W boson in hadron collisions. We present a fully exclusive calculation up to next-to-next-to-leading order (NNLO) in QCD perturbation theory. To perform this NNLO computation, we use a recently proposed version of the subtraction formalism. Our calculation includes finite-width effects, the leptonic decay of the W boson with its spin correlations, and the decay of the Higgs boson into a bb pair. We present selected numerical results at the Tevatron and the LHC.

Ethical issues of global corporatization: agriculture and beyond.

PubMed

Pimentel, D

2004-03-01

The world food supply has become inadequate for more than half the world population, as evidenced by a recent report of the World Health Organization that indicated that more than 3 billion people are malnourished. This is the largest number of malnourished ever reported. Per capita food production, especially cereal grains, has been declining for nearly 2 decades, despite new biotechnology and other agricultural technologies. Rapid human population growth, compounded by diminishing availability of fertile cropland, freshwater, and fossil fuels, is intensifying the emerging problems in all food production systems. Numerous ethical issues are related to the problem of malnutrition, including global corporatization.

Near-real-time Estimation and Forecast of Total Precipitable Water in Europe

NASA Astrophysics Data System (ADS)

Bartholy, J.; Kern, A.; Barcza, Z.; Pongracz, R.; Ihasz, I.; Kovacs, R.; Ferencz, C.

2013-12-01

Information about the amount and spatial distribution of atmospheric water vapor (or total precipitable water) is essential for understanding weather and the environment including the greenhouse effect, the climate system with its feedbacks and the hydrological cycle. Numerical weather prediction (NWP) models need accurate estimations of water vapor content to provide realistic forecasts including representation of clouds and precipitation. In the present study we introduce our research activity for the estimation and forecast of atmospheric water vapor in Central Europe using both observations and models. The Eötvös Loránd University (Hungary) operates a polar orbiting satellite receiving station in Budapest since 2002. This station receives Earth observation data from polar orbiting satellites including MODerate resolution Imaging Spectroradiometer (MODIS) Direct Broadcast (DB) data stream from satellites Terra and Aqua. The received DB MODIS data are automatically processed using freely distributed software packages. Using the IMAPP Level2 software total precipitable water is calculated operationally using two different methods. Quality of the TPW estimations is a crucial question for further application of the results, thus validation of the remotely sensed total precipitable water fields is presented using radiosonde data. In a current research project in Hungary we aim to compare different estimations of atmospheric water vapor content. Within the frame of the project we use a NWP model (DBCRAS; Direct Broadcast CIMSS Regional Assimilation System numerical weather prediction software developed by the University of Wisconsin, Madison) to forecast TPW. DBCRAS uses near real time Level2 products from the MODIS data processing chain. From the wide range of the derived Level2 products the MODIS TPW parameter found within the so-called mod07 results (Atmospheric Profiles Product) and the cloud top pressure and cloud effective emissivity parameters from the so-called mod06 results (Cloud Product) are assimilated twice a day (at 00 and 12 UTC) by DBCRAS. DBCRAS creates 72 hours long weather forecasts with 48 km horizontal resolution. DBCRAS is operational at the University since 2009 which means that by now sufficient data is available for the verification of the model. In the present study verification results for the DBCRAS total precipitable water forecasts are presented based on analysis data from the European Centre for Medium-Range Weather Forecasts (ECMWF). Numerical indices are calculated to quantify the performance of DBCRAS. During a limited time period DBCRAS was also ran without assimilating MODIS products which means that there is possibility to quantify the effect of assimilating MODIS physical products on the quality of the forecasts. For this limited time period verification indices are compared to decide whether MODIS data improves forecast quality or not.

Long-term infusions of ghrelin and obestatin in early lactation dairy cows.

PubMed

Roche, J R; Sheahan, A J; Chagas, L M; Blache, D; Berry, D P; Kay, J K

2008-12-01

Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor and a potential orexigenic agent in monogastrics and ruminants. Obestatin has been reported to have the opposite (anorexigenic) effect. Fifty one multiparous cows were randomly allocated to 1 of 3 groups (n = 17): a control group and 2 groups with cows continuously infused with 0.74 mumol/d of ghrelin (GHR group) or obestatin (OBE group) subcutaneously. Infusions began 21 d in milk, and treatments continued for 8 wk. Generalized linear models were used to determine the treatment effect on average daily and cumulative milk production and composition, and plasma ghrelin, growth hormone, insulin-like growth factor (IGF)-1, leptin, nonesterified fatty acids, and glucose. Mixed models, with cow included as a repeated effect, were used to determine if treatment effects differed by week postcalving for milk production, body weight, and body condition score (BCS; scale 1 to 10). Parity, breed, week of the year at calving, treatment, week postcalving, and the 2 wk preexperimental average of each measure (covariate) were included as fixed effects. Treatment did not affect dry matter intake. Cows infused with GHR lost more BCS (-0.71 units) over the 8-wk study period than the control (-0.23 BCS units) cows, and on average were thinner than cows in either of the other 2 treatments (0.2 BCS units). Consistent with the extra BCS loss in GHR cows, plasma IGF-1, glucose, and leptin concentrations were reduced and plasma nonesterified fatty acid concentrations were greater in GHR cows. Despite a numerical tendency for GHR cows to produce more milk (1,779 kg) than control (1,681 kg) or OBE (1,714 kg) cows during the 8-wk period, milk production differences were not statistically different. However, the timing of the numerical separation of the lactation curves coincided with the significant changes in BCS, IGF-1, and leptin. Results indicate a positive effect of ghrelin infusion on lipolysis. Further research is required to determine if the numerical increase in milk production, which coincides with the increased negative energy balance, is real.

Analysis of the thermo-mechanical deformations in a hot forging tool by numerical simulation

NASA Astrophysics Data System (ADS)

L-Cancelos, R.; Varas, F.; Martín, E.; Viéitez, I.

2016-03-01

Although programs have been developed for the design of tools for hot forging, its design is still largely based on the experience of the tool maker. This obliges to build some test matrices and correct their errors to minimize distortions in the forged piece. This phase prior to mass production consumes time and material resources, which makes the final product more expensive. The forging tools are usually constituted by various parts made of different grades of steel, which in turn have different mechanical properties and therefore suffer different degrees of strain. Furthermore, the tools used in the hot forging are exposed to a thermal field that also induces strain or stress based on the degree of confinement of the piece. Therefore, the mechanical behaviour of the assembly is determined by the contact between the different pieces. The numerical simulation allows to analyse different configurations and anticipate possible defects before tool making, thus, reducing the costs of this preliminary phase. In order to improve the dimensional quality of the manufactured parts, the work presented here focuses on the application of a numerical model to a hot forging manufacturing process in order to predict the areas of the forging die subjected to large deformations. The thermo-mechanical model developed and implemented with free software (Code-Aster) includes the strains of thermal origin, strains during forge impact and contact effects. The numerical results are validated with experimental measurements in a tooling set that produces forged crankshafts for the automotive industry. The numerical results show good agreement with the experimental tests. Thereby, a very useful tool for the design of tooling sets for hot forging is achieved.

The role of the atmosphere in the provision of ecosystem services.

PubMed

Cooter, Ellen J; Rea, Anne; Bruins, Randy; Schwede, Donna; Dennis, Robin

2013-03-15

Solving the environmental problems that we are facing today requires holistic approaches to analysis and decision making that include social and economic aspects. The concept of ecosystem services, defined as the benefits people obtain from ecosystems, is one potential tool to perform such assessments. The objective of this paper is to demonstrate the need for an integrated approach that explicitly includes the contribution of atmospheric processes and functions to the quantification of air-ecosystem services. First, final and intermediate air-ecosystem services are defined. Next, an ecological production function for clean and clear air is described, and its numerical counterpart (the Community Multiscale Air Quality model) is introduced. An illustrative numerical example is developed that simulates potential changes in air-ecosystem services associated with the conversion of evergreen forest land in Mississippi, Alabama and Georgia to commercial crop land. This one-atmosphere approach captures a broad range of service increases and decreases. Results for the forest to cropland conversion scenario suggest that although such change could lead to increased biomass (food) production services, there could also be coincident, seasonally variable decreases in clean and clear air-ecosystem services (i.e., increased levels of ozone and particulate matter) associated with increased fertilizer application. Metrics that support the quantification of these regional air-ecosystem changes require regional ecosystem production functions that fully integrate biotic as well as abiotic components of terrestrial ecosystems, and do so on finer temporal scales than are used for the assessment of most ecosystem services. Published by Elsevier B.V.

Lights Out Operations of a Space, Ground, Sensorweb

NASA Technical Reports Server (NTRS)

Chien, Steve; Tran, Daniel; Johnston, Mark; Davies, Ashley Gerard; Castano, Rebecca; Rabideau, Gregg; Cichy, Benjamin; Doubleday, Joshua; Pieri, David; Scharenbroich, Lucas;

Analysis models for the estimation of oceanic fields

NASA Technical Reports Server (NTRS)

Carter, E. F.; Robinson, A. R.

1987-01-01

A general model for statistically optimal estimates is presented for dealing with scalar, vector and multivariate datasets. The method deals with anisotropic fields and treats space and time dependence equivalently. Problems addressed include the analysis, or the production of synoptic time series of regularly gridded fields from irregular and gappy datasets, and the estimate of fields by compositing observations from several different instruments and sampling schemes. Technical issues are discussed, including the convergence of statistical estimates, the choice of representation of the correlations, the influential domain of an observation, and the efficiency of numerical computations.

Tastes associated with products in contact with drinking water.

PubMed

Marchesan, M; Morran, J

2004-01-01

Over the past 9 years the Australian Water Quality Centre (AWQC) has conducted testing in accordance with Australian and New Zealand Standard AS/NZS 4020--"Products for use in contact with drinking water" (1999). A test included as part of this standard is taste of water extracts. This test assesses the ability of products to impart discernible taste to drinking water using panellists trained in accordance with Standard Methods for the Examination of Water and Wastewater--Flavour Profile Analysis 2170 B (1999). Over 1000 products from companies worldwide, have been assessed at the AWQC in accordance with AS/NZS 4020 including pipes, valves, tap fittings and numerous other products used in contact with water. The products must not impart any discernible taste to obtain compliance and be deemed suitable for use in contact with drinking water. This study compiles the products assessed and the types of tastes obtained from both chlorinated and non-chlorinated extracts. In particular the study focuses on taste associated with polyethylene pipes, coatings and valves, which in some instances have been problematic. Analysis revealed that most taste problems occur when chlorinated water has been used in extraction experiments and this is in line with consumer complaints regarding taste imparted by plumbing products. The collation of this data provides a valuable assessment for manufacturers, the water industry and consumers.

Numerical simulations of epitaxial growth process in MOVPE reactor as a tool for design of modern semiconductors for high power electronics

NASA Astrophysics Data System (ADS)

Skibinski, Jakub; Caban, Piotr; Wejrzanowski, Tomasz; Kurzydlowski, Krzysztof J.

2014-10-01

In the present study numerical simulations of epitaxial growth of gallium nitride in Metal Organic Vapor Phase Epitaxy reactor AIX-200/4RF-S is addressed. Epitaxial growth means crystal growth that progresses while inheriting the laminar structure and the orientation of substrate crystals. One of the technological problems is to obtain homogeneous growth rate over the main deposit area. Since there are many agents influencing reaction on crystal area such as temperature, pressure, gas flow or reactor geometry, it is difficult to design optimal process. According to the fact that it's impossible to determine experimentally the exact distribution of heat and mass transfer inside the reactor during crystal growth, modeling is the only solution to understand the process precisely. Numerical simulations allow to understand the epitaxial process by calculation of heat and mass transfer distribution during growth of gallium nitride. Including chemical reactions in numerical model allows to calculate the growth rate of the substrate and estimate the optimal process conditions for obtaining the most homogeneous product.

General method and thermodynamic tables for computation of equilibrium composition and temperature of chemical reactions

NASA Technical Reports Server (NTRS)

Huff, Vearl N; Gordon, Sanford; Morrell, Virginia E

1951-01-01

A rapidly convergent successive approximation process is described that simultaneously determines both composition and temperature resulting from a chemical reaction. This method is suitable for use with any set of reactants over the complete range of mixture ratios as long as the products of reaction are ideal gases. An approximate treatment of limited amounts of liquids and solids is also included. This method is particularly suited to problems having a large number of products of reaction and to problems that require determination of such properties as specific heat or velocity of sound of a dissociating mixture. The method presented is applicable to a wide variety of problems that include (1) combustion at constant pressure or volume; and (2) isentropic expansion to an assigned pressure, temperature, or Mach number. Tables of thermodynamic functions needed with this method are included for 42 substances for convenience in numerical computations.

Phospholipids and products of their hydrolysis as dietary preventive factors for civilization diseases.

PubMed

Parchem, Karol; Bartoszek, Agnieszka

2016-12-31

The results of numerous epidemiological studies indicate that phospholipids play an important role in the prevention of chronic diseases faced by contemporary society. Firstly, these compounds are responsible for the proper functioning of cell membranes, by ensuring liquidity and permeability, which is pivotal for normal activity of membrane proteins, including receptors. These mechanisms are at the core of prevention of cancer, autoimmune or neurological disorders. Secondly, structure and properties of phospholipids cause that they are highly available source of biologically active fatty acids. Thirdly, also products of endogenous hydrolysis of phospholipids exhibit biological activity. These include lysophospholipids formed as a result of disconnecting free fatty acid from glycerophospholipids in the reaction catalyzed by phospholipase A, phosphatidic acid and hydrophilic subunits released by the activity of phospholipase D. The bioactive products of hydrolysis also include ceramides liberated from phosphosphingolipids after removal of a hydrophilic unit catalyzed by sphingomyelinase. Phospholipids are supplied to the human body with food. A high content of phospholipids is characteristic for egg yolk, liver, pork and poultry, as well as some soy products. Particularly beneficial are phospholipids derived from seafood because they are a rich source of essential fatty acids of the n-3 family.

The Unidata LDM Data Distribution System

NASA Astrophysics Data System (ADS)

Emmerson, S.; Yoksas, T. C.; Weber, W. J.; Schmidt, M.

2010-12-01

The Unidata LDM is a near real-time, event-driven system for transmitting frequently-generated data-products, 24/7, from a producer to multiple subscribers using the Internet. Once received, a data-product is processed according to user specifications. A data-product can be anything up to 4 gigabytes in size. Downstream LDM-s register a regular expression based selection predicate with upstream LDM-s. Network topologies include point-to-point, star, and tree. Based on ONC RPC, the LDM system is extremely robust and efficient. Since its initial release in 1994, a network of LDM-s called the Internet Data Distribution (IDD) system has been the primary means by which many if not most Earth Sciences departments in the US obtain and process meteorological data (up to 20 GB/hour and 250k products/hour) with latencies measured in seconds or less. Data-products include numerical model output, radar data, WMO bulletins, and lightning data. Users of the LDM also include the international atmospheric science university community, NOAA, NASA, USGS, the US military, ECMWF, and the meteorological agencies of China, Australia, Brazil, South Korea, and Vietnam. The LDM is the highest volume advanced application on Internet-2 (currently averaging 27 terabytes per week). The LDM history and architecture is presented together with an analysis of its strengths and weaknesses.

Numerical Investigation of Aluminum Burning Behind Blast Waves

DTIC Science & Technology

2010-10-01

Lai, and K.S. Im, “ Afterburning of TNT Explosive Products in Air with Aluminum Particles,” AIAA-2008-1029, 2008 [2] K. Balakrishnan and S. Menon...phase flow was applied. The modeled HE includes a significant percentage of aluminum particles, whose long-time afterburning and energy release must...the physical mechanisms are even more complex. The flow environment is significantly different from bare charge detonation and afterburn . As long

The Six Pillars of Influence: How Insurgent Organizations Manipulate Governments, Populations, and Their Operatives

DTIC Science & Technology

2009-03-01

Work, which has numerous business clients including IBM, Coca Cola , and Harvard University. C. CIALDINI’S PRINCIPLES OF INFLUENCE 1. Reciprocation...various advertising , public relations, and fund-raising agencies in order to learn these compliance methods from those that practice them. In his...associating the product (or themselves) with positive ideas and images. This is demonstrated in advertising by invoking the “official sponsor” moniker

REVIEWS OF TOPICAL PROBLEMS: The search for dark matter particles

NASA Astrophysics Data System (ADS)

Ryabov, Vladimir A.; Tsarev, Vladimir A.; Tskhovrebov, Andrei M.

2008-11-01

Evidence of dark matter in the Universe is discussed and the most popular candidates for dark matter particles are reviewed. The review is mainly devoted to numerous experiments, both underway and planned, on the search for dark matter particles. Various experimental methods are discussed, including those involving direct registration of dark matter particles with the detector and those where the products of dark matter decay and annihilation are registered.

An Impulse Based Substructuring approach for impact analysis and load case simulations

NASA Astrophysics Data System (ADS)

Rixen, Daniel J.; van der Valk, Paul L. C.

2013-12-01

In the present paper we outline the basic theory of assembling substructures for which the dynamics are described as Impulse Response Functions. The assembly procedure computes the time response of a system by evaluating per substructure the convolution product between the Impulse Response Functions and the applied forces, including the interface forces that are computed to satisfy the interface compatibility. We call this approach the Impulse Based Substructuring method since it transposes to the time domain the Frequency Based Substructuring approach. In the Impulse Based Substructuring technique the Impulse Response Functions of the substructures can be gathered either from experimental tests using a hammer impact or from time-integration of numerical submodels. In this paper the implementation of the method is outlined for the case when the impulse responses of the substructures are computed numerically. A simple bar example is shown in order to illustrate the concept. The Impulse Based Substructuring allows fast evaluation of impact response of a structure when the impulse response of its components is known. It can thus be used to efficiently optimize designs of consumer products by including impact behavior at the early stage of the design, but also for performing substructured simulations of complex structures such as offshore wind turbines.

Thermal characterization of full-scale PCM products and numerical simulations, including hysteresis, to evaluate energy impacts in an envelope application

DOE PAGES

Biswas, Kaushik; Shukla, Yash; Desjarlais, Andre Omer; ...

2018-04-17

This article presents combined measurements of fatty acid-based organic PCM products and numerical simulations to evaluate the energy benefits of adding a PCM layer to an exterior wall. The thermal storage characteristics of the PCM were measured using a heat flow meter apparatus (HFMA). The PCM characterization is based on a recent ASTM International standard test method, ASTM C1784. The PCM samples were subjected to step changes in temperature and allowed to stabilize at each temperature. By measuring the heat absorbed or released by the PCM, the temperature-dependent enthalpy functions for melting and freezing were determined.Here, the simulations were donemore » using a previously-validated two-dimensional (2D) wall model containing a PCM layer and incorporating the HFMA-measured enthalpy functions. The wall model was modified to include the hysteresis phenomenon observed in PCMs, which is reflected in different melting and freezing temperatures of the PCM. Simulations were done with a single enthalpy curve based on the PCM melting tests, both melting and freezing enthalpy curves, and with different degrees of hysteresis between the melting and freezing curves. Significant differences were observed between the thermal performances of the modeled wall with the PCM layer under the different scenarios.« less

Thermal characterization of full-scale PCM products and numerical simulations, including hysteresis, to evaluate energy impacts in an envelope application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biswas, Kaushik; Shukla, Yash; Desjarlais, Andre Omer

This article presents combined measurements of fatty acid-based organic PCM products and numerical simulations to evaluate the energy benefits of adding a PCM layer to an exterior wall. The thermal storage characteristics of the PCM were measured using a heat flow meter apparatus (HFMA). The PCM characterization is based on a recent ASTM International standard test method, ASTM C1784. The PCM samples were subjected to step changes in temperature and allowed to stabilize at each temperature. By measuring the heat absorbed or released by the PCM, the temperature-dependent enthalpy functions for melting and freezing were determined.Here, the simulations were donemore » using a previously-validated two-dimensional (2D) wall model containing a PCM layer and incorporating the HFMA-measured enthalpy functions. The wall model was modified to include the hysteresis phenomenon observed in PCMs, which is reflected in different melting and freezing temperatures of the PCM. Simulations were done with a single enthalpy curve based on the PCM melting tests, both melting and freezing enthalpy curves, and with different degrees of hysteresis between the melting and freezing curves. Significant differences were observed between the thermal performances of the modeled wall with the PCM layer under the different scenarios.« less

Technical Support for Contaminated Sites | Science Inventory ...

EPA Pesticide Factsheets

In 1987, the U.S. Environmental Protection Agency’s (EPA) Office of Research and Development (ORD), Office of Land and Emergency Management, and EPA Regional waste management offices established the Technical Support Project. The creation of the Technical Support Project enabled ORD to provide effective technical assistance by ensuring ORD scientists and engineers were accessible to the Agency’s Office and Regional decision makers, including Remedial Project Managers, On-Scene Coordinators, and corrective action staff. Five ORD Technical Support Centers (TSCs) were created to facilitate this technical assistance. Three of the five TSCs are supported by the Sustainable and Healthy Communities Research Program, and are summarized in the poster being presented:• Engineering Technical Support Center (ETSC) in Cincinnati, Ohio• Ground Water Technical Support Center (GWTSC) in Ada, Oklahoma• Site Characterization and Monitoring Technical Support Center (SCMTSC) in Atlanta, GeorgiaOver the past 29 years, the Technical Support Centers have provided numerous influential products to its internal Agency clients and to those at the State level (through the EPA Regions). These products include, but are not limited to the following: Annual TSC reports from the three Centers, a hard-rock mining conference every other year, PRO-UCL software development for site characterization statistics, groundwater modeling using state-of-the-art modeling software, numerical mo

Differentiation of commercial fuels based on polar components using negative electrospray ionization/mass spectrometry

USGS Publications Warehouse

Rostad, C.E.

2006-01-01

Polar components in fuels may enable differentiation between fuel types or commercial fuel sources. A range of commercial fuels from numerous sources were analyzed by flow injection analysis/electrospray ionization/mass spectrometry without extensive sample preparation, separation, or chromatography. This technique enabled screening for unique polar components at parts per million levels in commercial hydrocarbon products, including a range of products from a variety of commercial sources and locations. Because these polar compounds are unique in different fuels, their presence may provide source information on hydrocarbons released into the environment. This analysis was then applied to mixtures of various products, as might be found in accidental releases into the environment. Copyright ?? Taylor & Francis Group, LLC.

The development of microalgal biotechnology in the Czech Republic.

PubMed

Masojídek, Jiří; Prášil, Ondřej

2010-12-01

Microscopic algae and cyanobacteria are excellent sources of numerous compounds, from raw biomass rich in proteins, oils, and antioxidants to valuable secondary metabolites with potential medical use. In the former Czechoslovakia, microalgal biotechnology developed rapidly in the 1960s with the main aim of providing industrial, high-yield sources of algal biomass. Unique cultivation techniques that are still in use were successfully developed and tested. Gradually, the focus changed from bulk production to more sophisticated use of microalgae, including production of bioactive compounds. Along the way, better understanding of the physiology and cell biology of productive microalgal strains was achieved. Currently, microalgae are in the focus again, mostly as possible sources of bioactive compounds and next-generation biofuels for the 21st century.

The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update.

PubMed

Elahi, Merina; Eshera, Noha; Bambata, Nkosazana; Barr, Helen; Lyn-Cook, Beverly; Beitz, Julie; Rios, Maria; Taylor, Deborah R; Lightfoote, Marilyn; Hanafi, Nada; DeJager, Lowri; Wiesenfeld, Paddy; Scott, Pamela E; Fadiran, Emmanuel O; Henderson, Marsha B

2016-03-01

The U.S. Food and Drug Administration Office of Women's Health (FDA OWH) has supported women's health research for ∼20 years, funding more than 300 studies on women's health issues, including research on diseases/conditions that disproportionately affect women in addition to the evaluation of sex differences in the performance of and response to medical products. These important women's health issues are studied from a regulatory perspective, with a focus on improving and optimizing medical product development and the evaluation of product safety and efficacy in women. These findings have influenced industry direction, labeling, product discontinuation, safety notices, and clinical practice. In addition, OWH-funded research has addressed gaps in the knowledge about diseases and medical conditions that impact women across the life span such as cardiovascular disease, pregnancy, menopause, osteoporosis, and the safe use of numerous medical products.

Natural Products and Supplements for Geriatric Depression and Cognitive Disorders: An Evaluation of the Research

PubMed Central

Varteresian, Taya; Lavretsky, Helen

2014-01-01

Numerous geriatric patients are using Complementary and Alternative Medicine (CAM) for late-life mood and cognitive disorders. Natural products and supplements are a common CAM intervention which have risks and benefits of which patients should be appropriately advised. The data for omega-3 fatty acids, ginkgo biloba, SAMe, St John’s wort, B Vitamins and Vitamin D, huperzine, caprylidene and coconut oil will be evaluated. Since the evidence basis for natural products and supplements is limited, especially for the geriatric population. Studies involving the general adult population are included to infer effects in the aging population. Despite the data available, more rigorous studies with larger sample sizes over longer periods of time are still needed. Regardless of a physician’s preference to recommend various natural supplements and products, a physician could protect their patients by having an understanding of the side effects and indications for various natural products. PMID:24912606

The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update

PubMed Central

Elahi, Merina; Eshera, Noha; Bambata, Nkosazana; Barr, Helen; Lyn-Cook, Beverly; Beitz, Julie; Rios, Maria; Taylor, Deborah R.; Lightfoote, Marilyn; Hanafi, Nada; DeJager, Lowri; Wiesenfeld, Paddy; Scott, Pamela E.; Henderson, Marsha B.

2016-01-01

Abstract The U.S. Food and Drug Administration Office of Women's Health (FDA OWH) has supported women's health research for ∼20 years, funding more than 300 studies on women's health issues, including research on diseases/conditions that disproportionately affect women in addition to the evaluation of sex differences in the performance of and response to medical products. These important women's health issues are studied from a regulatory perspective, with a focus on improving and optimizing medical product development and the evaluation of product safety and efficacy in women. These findings have influenced industry direction, labeling, product discontinuation, safety notices, and clinical practice. In addition, OWH-funded research has addressed gaps in the knowledge about diseases and medical conditions that impact women across the life span such as cardiovascular disease, pregnancy, menopause, osteoporosis, and the safe use of numerous medical products. PMID:26871618

Designing Adaptive Low-Dissipative High Order Schemes for Long-Time Integrations. Chapter 1

NASA Technical Reports Server (NTRS)

Yee, Helen C.; Sjoegreen, B.; Mansour, Nagi N. (Technical Monitor)

2001-01-01

A general framework for the design of adaptive low-dissipative high order schemes is presented. It encompasses a rather complete treatment of the numerical approach based on four integrated design criteria: (1) For stability considerations, condition the governing equations before the application of the appropriate numerical scheme whenever it is possible; (2) For consistency, compatible schemes that possess stability properties, including physical and numerical boundary condition treatments, similar to those of the discrete analogue of the continuum are preferred; (3) For the minimization of numerical dissipation contamination, efficient and adaptive numerical dissipation control to further improve nonlinear stability and accuracy should be used; and (4) For practical considerations, the numerical approach should be efficient and applicable to general geometries, and an efficient and reliable dynamic grid adaptation should be used if necessary. These design criteria are, in general, very useful to a wide spectrum of flow simulations. However, the demand on the overall numerical approach for nonlinear stability and accuracy is much more stringent for long-time integration of complex multiscale viscous shock/shear/turbulence/acoustics interactions and numerical combustion. Robust classical numerical methods for less complex flow physics are not suitable or practical for such applications. The present approach is designed expressly to address such flow problems, especially unsteady flows. The minimization of employing very fine grids to overcome the production of spurious numerical solutions and/or instability due to under-resolved grids is also sought. The incremental studies to illustrate the performance of the approach are summarized. Extensive testing and full implementation of the approach is forthcoming. The results shown so far are very encouraging.

Parallel language constructs for tensor product computations on loosely coupled architectures

NASA Technical Reports Server (NTRS)

Mehrotra, Piyush; Van Rosendale, John

1989-01-01

A set of language primitives designed to allow the specification of parallel numerical algorithms at a higher level is described. The authors focus on tensor product array computations, a simple but important class of numerical algorithms. They consider first the problem of programming one-dimensional kernel routines, such as parallel tridiagonal solvers, and then look at how such parallel kernels can be combined to form parallel tensor product algorithms.

GEN-IV Benchmarking of Triso Fuel Performance Models under accident conditions modeling input data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collin, Blaise Paul

This document presents the benchmark plan for the calculation of particle fuel performance on safety testing experiments that are representative of operational accidental transients. The benchmark is dedicated to the modeling of fission product release under accident conditions by fuel performance codes from around the world, and the subsequent comparison to post-irradiation experiment (PIE) data from the modeled heating tests. The accident condition benchmark is divided into three parts: • The modeling of a simplified benchmark problem to assess potential numerical calculation issues at low fission product release. • The modeling of the AGR-1 and HFR-EU1bis safety testing experiments. •more » The comparison of the AGR-1 and HFR-EU1bis modeling results with PIE data. The simplified benchmark case, thereafter named NCC (Numerical Calculation Case), is derived from “Case 5” of the International Atomic Energy Agency (IAEA) Coordinated Research Program (CRP) on coated particle fuel technology [IAEA 2012]. It is included so participants can evaluate their codes at low fission product release. “Case 5” of the IAEA CRP-6 showed large code-to-code discrepancies in the release of fission products, which were attributed to “effects of the numerical calculation method rather than the physical model” [IAEA 2012]. The NCC is therefore intended to check if these numerical effects subsist. The first two steps imply the involvement of the benchmark participants with a modeling effort following the guidelines and recommendations provided by this document. The third step involves the collection of the modeling results by Idaho National Laboratory (INL) and the comparison of these results with the available PIE data. The objective of this document is to provide all necessary input data to model the benchmark cases, and to give some methodology guidelines and recommendations in order to make all results suitable for comparison with each other. The participants should read this document thoroughly to make sure all the data needed for their calculations is provided in the document. Missing data will be added to a revision of the document if necessary. 09/2016: Tables 6 and 8 updated. AGR-2 input data added« less

Generation IV benchmarking of TRISO fuel performance models under accident conditions: Modeling input data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collin, Blaise P.

2014-09-01

This document presents the benchmark plan for the calculation of particle fuel performance on safety testing experiments that are representative of operational accidental transients. The benchmark is dedicated to the modeling of fission product release under accident conditions by fuel performance codes from around the world, and the subsequent comparison to post-irradiation experiment (PIE) data from the modeled heating tests. The accident condition benchmark is divided into three parts: the modeling of a simplified benchmark problem to assess potential numerical calculation issues at low fission product release; the modeling of the AGR-1 and HFR-EU1bis safety testing experiments; and, the comparisonmore » of the AGR-1 and HFR-EU1bis modeling results with PIE data. The simplified benchmark case, thereafter named NCC (Numerical Calculation Case), is derived from ''Case 5'' of the International Atomic Energy Agency (IAEA) Coordinated Research Program (CRP) on coated particle fuel technology [IAEA 2012]. It is included so participants can evaluate their codes at low fission product release. ''Case 5'' of the IAEA CRP-6 showed large code-to-code discrepancies in the release of fission products, which were attributed to ''effects of the numerical calculation method rather than the physical model''[IAEA 2012]. The NCC is therefore intended to check if these numerical effects subsist. The first two steps imply the involvement of the benchmark participants with a modeling effort following the guidelines and recommendations provided by this document. The third step involves the collection of the modeling results by Idaho National Laboratory (INL) and the comparison of these results with the available PIE data. The objective of this document is to provide all necessary input data to model the benchmark cases, and to give some methodology guidelines and recommendations in order to make all results suitable for comparison with each other. The participants should read this document thoroughly to make sure all the data needed for their calculations is provided in the document. Missing data will be added to a revision of the document if necessary.« less

Engineering microbial chemical factories to produce renewable "biomonomers".

PubMed

Adkins, Jake; Pugh, Shawn; McKenna, Rebekah; Nielsen, David R

2012-01-01

By applying metabolic engineering tools and strategies to engineer synthetic enzyme pathways, the number and diversity of commodity and specialty chemicals that can be derived directly from renewable feedstocks is rapidly and continually expanding. This of course includes a number of monomer building-block chemicals that can be used to produce replacements to many conventional plastic materials. This review aims to highlight numerous recent and important advancements in the microbial production of these so-called "biomonomers." Relative to naturally-occurring renewable bioplastics, biomonomers offer several important advantages, including improved control over the final polymer structure and purity, the ability to synthesize non-natural copolymers, and allowing products to be excreted from cells which ultimately streamlines downstream recovery and purification. To highlight these features, a handful of biomonomers have been selected as illustrative examples of recent works, including polyamide monomers, styrenic vinyls, hydroxyacids, and diols. Where appropriate, examples of their industrial penetration to date and end-product uses are also highlighted. Novel biomonomers such as these are ultimately paving the way toward new classes of renewable bioplastics that possess a broader diversity of properties than ever before possible.

Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, tar and nicotine yields

PubMed Central

Shihadeh, Alan; Salman, Rola; Jaroudi, Ezzat; Saliba, Najat; Sepetdjian, Elizabeth; Blank, Melissa D.; Cobb, Caroline O.; Eissenberg, Thomas

2012-01-01

Waterpipe (hookah, narghile, shisha) use has become a global phenomenon, with numerous product variations. One variation is a class of products marketed as “tobacco-free” alternatives for the “health conscious user”. In this study toxicant yields from waterpipes smoked using conventional tobacco-based and tobacco-free preparations were compared. A human-mimic waterpipe smoking machine was used to replicate the puffing sequences of 31 human participants who completed two double-blind ad libitum smoking sessions in a controlled clinical setting: once with a tobacco-based product of their choosing and once with a flavor-matched tobacco-free product. Outcome measures included yields of carbon monoxide, nitric oxide, volatile aldehydes, nicotine, tar, and polycyclic aromatic hydrocarbons. Smoke from both waterpipe preparations contained substantial quantities of toxicants. Nicotine yield was the only outcome that differed significantly between preparations. These findings contradict advertising messages that “herbal” waterpipe products are a healthy alternative to tobacco products. PMID:22406330

Mitochondria control acute and chronic responses to hypoxia.

PubMed

McElroy, G S; Chandel, N S

2017-07-15

There are numerous mechanisms by which mammals respond to hypoxia. These include acute changes in pulmonary arterial tone due to smooth muscle cell contraction, acute increases in respiration triggered by the carotid body chemosensory cells, and chronic changes such as induction of red blood cell proliferation and angiogenesis by hypoxia inducible factor targets erythropoietin and vascular endothelial growth factor, respectively. Mitochondria account for the majority of oxygen consumption in the cell and have recently been appreciated to serve as signaling organelles required for the initiation or propagation of numerous homeostatic mechanisms. Mitochondria can influence cell signaling by production of reactive oxygen species and metabolites. Here we review recent evidence that mitochondrial signals can imitate acute and chronic hypoxia responses. Copyright © 2017 Elsevier Inc. All rights reserved.

Large-Scale 3D Printing: The Way Forward

NASA Astrophysics Data System (ADS)

Jassmi, Hamad Al; Najjar, Fady Al; Ismail Mourad, Abdel-Hamid

2018-03-01

Research on small-scale 3D printing has rapidly evolved, where numerous industrial products have been tested and successfully applied. Nonetheless, research on large-scale 3D printing, directed to large-scale applications such as construction and automotive manufacturing, yet demands a great a great deal of efforts. Large-scale 3D printing is considered an interdisciplinary topic and requires establishing a blended knowledge base from numerous research fields including structural engineering, materials science, mechatronics, software engineering, artificial intelligence and architectural engineering. This review article summarizes key topics of relevance to new research trends on large-scale 3D printing, particularly pertaining (1) technological solutions of additive construction (i.e. the 3D printers themselves), (2) materials science challenges, and (3) new design opportunities.

Production of succinic acid by metabolically engineered microorganisms.

PubMed

Ahn, Jung Ho; Jang, Yu-Sin; Lee, Sang Yup

2016-12-01

Succinic acid (SA) has been recognized as one of the most important bio-based building block chemicals due to its numerous potential applications. For the economical bio-based production of SA, extensive research works have been performed on developing microbial strains by metabolic engineering as well as fermentation and downstream processes. Here we review metabolic engineering strategies applied for bio-based production of SA using representative microorganisms, including Saccharomyces cerevisiae, Pichia kudriavzevii, Escherichia coli, Mannheimia succiniciproducens, Basfia succiniciproducens, Actinobacillus succinogenes, and Corynebacterium glutamicum. In particular, strategies employed for developing engineered strains of these microorganisms leading to the best performance indices (titer, yield, and productivity) are showcased based on the published papers as well as patents. Those processes currently under commercialization are also analyzed and future perspectives are provided. Copyright © 2016 Elsevier Ltd. All rights reserved.

Full-waveform, Laser Altimeter Measurements of Vegetation Vertical Structure and Sub-canopy Topography in Support of the North American Carbon Program

NASA Technical Reports Server (NTRS)

Blair, B.; Hofton, M.; Rabine, D.; Padden, P.; Rhoads, J.

2004-01-01

Full-waveform, scanning laser altimeters (i.e. lidar) provide a unique and precise view of the vertical and horizontal structure of vegetation across wide swaths. These unique laser altimeters systems are able to simultaneously image sub-canopy topography and the vertical structure of any overlying vegetation. These data reveal the true 3-D distribution of vegetation in leaf-on conditions enabling important biophysical parameters such as canopy height and aboveground biomass to be estimated with unprecedented accuracy. An airborne lidar mission was conducted in the summer of 2003 in support of preliminary studies for the North America Carbon Program. NASA's Laser Vegetation Imaging Sensor (LVIS) was used to image approximately 2,000 sq km in Maine, New Hampshire, Massachusetts and Maryland. Areas with available ground and other data were included (e.g., experimental forests, FLUXNET sites) in order to facilitate numerous bio- and geophysical investigations. Data collected included ground elevation and canopy height measurements for each laser footprint, as well as the vertical distribution of intercepted surfaces (i.e. the return waveform). Data are currently available at the LVIS website (http://lvis.gsfc.nasa.gov/). Further details of the mission, including the lidar system technology, the locations of the mapped areas, and examples of the numerous data products that can be derived from the return waveform data products are available on the website and will be presented. Future applications including potential fusion with other remote sensing data sets and a spaceborne implementation of wide-swath, full-waveform imaging lidar will also be discussed.

Polystyrene foam products equation of state as a function of porosity and fill gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mulford, Roberta N; Swift, Damian C

2009-01-01

An accurate EOS for polystyrene foam is necessary for analysis of numerous experiments in shock compression, inertial confinement fusion, and astrophysics. Plastic to gas ratios vary between various samples of foam, according to the density and cell-size of the foam. A matrix of compositions has been investigated, allowing prediction of foam response as a function of the plastic-to-air ratio. The EOS code CHEETAH allows participation of the air in the decomposition reaction of the foam. Differences between air-filled, Ar-blown, and CO{sub 2}-blown foams are investigated, to estimate the importance of allowing air to react with products of polystyrene decomposition. O{submore » 2}-blown foams are included in some comparisons, to amplify any consequences of reaction with oxygen in air. He-blown foams are included in some comparisons, to provide an extremum of density. Product pressures are slightly higher for oxygen-containing fill gases than for non-oxygen-containing fill gases. Examination of product species indicates that CO{sub 2} decomposes at high temperatures.« less

Numerical simulations of depressurization-induced gas production from gas hydrate reservoirs at the Walker Ridge 312 site, northern Gulf of Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myshakin, Evgeniy M.; Gaddipati, Manohar; Rose, Kelly

2012-06-01

In 2009, the Gulf of Mexico (GOM) Gas Hydrates Joint-Industry-Project (JIP) Leg II drilling program confirmed that gas hydrate occurs at high saturations within reservoir-quality sands in the GOM. A comprehensive logging-while-drilling dataset was collected from seven wells at three sites, including two wells at the Walker Ridge 313 site. By constraining the saturations and thicknesses of hydrate-bearing sands using logging-while-drilling data, two-dimensional (2D), cylindrical, r-z and three-dimensional (3D) reservoir models were simulated. The gas hydrate occurrences inferred from seismic analysis are used to delineate the areal extent of the 3D reservoir models. Numerical simulations of gas production from themore » Walker Ridge reservoirs were conducted using the depressurization method at a constant bottomhole pressure. Results of these simulations indicate that these hydrate deposits are readily produced, owing to high intrinsic reservoir-quality and their proximity to the base of hydrate stability. The elevated in situ reservoir temperatures contribute to high (5–40 MMscf/day) predicted production rates. The production rates obtained from the 2D and 3D models are in close agreement. To evaluate the effect of spatial dimensions, the 2D reservoir domains were simulated at two outer radii. The results showed increased potential for formation of secondary hydrate and appearance of lag time for production rates as reservoir size increases. Similar phenomena were observed in the 3D reservoir models. The results also suggest that interbedded gas hydrate accumulations might be preferable targets for gas production in comparison with massive deposits. Hydrate in such accumulations can be readily dissociated due to heat supply from surrounding hydrate-free zones. Special cases were considered to evaluate the effect of overburden and underburden permeability on production. The obtained data show that production can be significantly degraded in comparison with a case using impermeable boundaries. The main reason for the reduced productivity is water influx from the surrounding strata; a secondary cause is gas escape into the overburden. The results dictate that in order to reliably estimate production potential, permeability of the surroundings has to be included in a model.« less

New products from the shuttle radar topography mission

USGS Publications Warehouse

Gesch, Dean B.; Farr, Tom; Slater, James; Muller, Jan-Peter; Cook, Sally

2006-01-01

Final products include elevation data resulting from a substantial editing effort by the NGA in which water bodies and coastlines were well defined and data artifacts known as spikes and wells (single pixel errors) were removed. This second version of the SRTM data set, also referred to as ‘finished’ data, represents a significant improvement over earlier versions that had nonflat water bodies, poorly defined coastlines, and numerous noise artifacts. The edited data are available at a one-arc-second resolution (approximately 30 meters) for the United States and its territories, and at a three-arc-second resolution (approximately 90 meters) for non-U.S. areas.

A Numerical Estimate of The Impact of The Saharan Dust On Medityerranean Trophic Web

NASA Astrophysics Data System (ADS)

Crise, A.; Crispi, G.

A first estimate of the importance of Saharan dust as input of macronutrients on the phytoplankton standing crop concentration and primary production at basin scale is here presented using a three-dimensional numerical model of the Mediterranean Sea. The numerical scheme adopted is a 1/4 degree resolution 31 levels MOM-based eco- hydrodynamical model with climatological ('perpetual year') forcings coupled on-line with a structure including multi-nutrient, size-fractionated phytoplankton functional groups, herbivores and a parametrized recycling detritus submodel, so to (explicitely or implicitely) include the major energy pathways of the upper layer mediterranean ecosystem. This model takes into account as potential limiting factors, among others, Nitrogen (in its oxidized and reduced forms) and Phosphorus. A gridded data setof (wet and dry) dust deposition over Mediterranean derived from SKIRON operational model is used to identify statistically the areas and the duration/intensity of the events. Starting from this averaging process, experiments are carried out to study the dust induced episodes of release of bioavailable phosphorus which is supposed to be the limiting factor in the oligotrophic waters of the surface layer in Med Sea. The metrics for the evaluation of the impact of deposition have been identified in phyto standing crop, primary and export production and switching in the food web functioning. These global parameters, even if cannot exaust the whealth of the informations provided by the model, can help discriminate the sensitivity of food web to the nutrient pulses induced by the deposition. First results of a scenario analysis of typical atmospheric input events, provide evidence of the response of the upper layer ecosystem to assess the sensitivity of the model predictions to the variability to integrated intensity of external input.

Evaluation of filamentous green algae as feedstocks for biofuel production.

PubMed

Zhang, Wei; Zhao, Yonggang; Cui, Binjie; Wang, Hui; Liu, Tianzhong

2016-11-01

Compared with unicellular microalgae, filamentous algae have high resistance to grazer-predation and low-cost recovery in large-scale production. Green algae, as the most diverse group of algae, included numerous filamentous genera and species. In this study, records of filamentous genera and species in green algae were firstly censused and classified. Then, seven filamentous strains subordinated in different genera were cultivated in bubbled-column to investigate their growth rate and energy molecular (lipid and starch) capacity. Four strains including Stigeoclonium sp., Oedogonium nodulosum, Hormidium sp. and Zygnema extenue were screened out due to their robust growth. And they all could accumulate triacylglycerols and starch in their biomass, but with different capacity. After nitrogen starvation, Hormidium sp. and Oedogonium nodulosum respectively exhibited high capacity of lipid (45.38% in dry weight) and starch (46.19% in dry weight) accumulation, which could be of high potential as feedstocks for biodiesel and bioethanol production. Copyright © 2016 Elsevier Ltd. All rights reserved.

Research on Equation of State For Detonation Products of Aluminized Explosive

NASA Astrophysics Data System (ADS)

Yue, Jun-Zheng; Duan, Zhuo-Ping; Zhang, Zhen-Yu; Ou, Zhuo-Cheng

2017-10-01

The secondary reaction of the aluminum powder contained in an aluminized explosive is investigated, from which the energy loss resulted from the quantity reduce of the gaseous products is demonstrated. Moreover, taking the energy loss into account, the existing improved Jones-Wilkins-Lee (JWL) equation of state for detonation products of aluminized explosive is modified. Furthermore, the new modified JWL equation of state is implemented into the dynamic analysis software (DYNA)-2D hydro-code to simulate numerically the metal plate acceleration tests of the Hexogen (RDX)-based aluminized explosives. It is found that the numerical results are in good agreement with previous experimental data. In addition, it is also demonstrated that the reaction rate of explosive before the Chapman-Jouget (CJ) state has little influence on the motion of the metal plate, based on which a simple approach is proposed to simulate numerically the products expansion process after the CJ state.

Utilisation of corn (Zea mays) bran and corn fiber in the production of food components.

PubMed

Rose, Devin J; Inglett, George E; Liu, Sean X

2010-04-30

The milling of corn for the production of food constituents results in a number of low-value co-products. Two of the major co-products produced by this operation are corn bran and corn fiber, which currently have low commercial value. This review focuses on current and prospective research surrounding the utilization of corn fiber and corn bran in the production of potentially higher-value food components. Corn bran and corn fiber contain potentially useful components that may be harvested through physical, chemical or enzymatic means for the production of food ingredients or additives, including corn fiber oil, corn fiber gum, cellulosic fiber gels, xylo-oligosaccharides and ferulic acid. Components of corn bran and corn fiber may also be converted to food chemicals such as vanillin and xylitol. Commercialization of processes for the isolation or production of food products from corn bran or corn fiber has been met with numerous technical challenges, therefore further research that improves the production of these components from corn bran or corn fiber is needed.

Comparative numerical study on the optimal vulcanization of rubber compounds through traditional curing and microwaves

NASA Astrophysics Data System (ADS)

Milani, Gabriele; Milani, Federico

2012-12-01

The main problem in the industrial production process of thick EPM/EPDM elements is constituted by the different temperatures which undergo internal (cooler) and external regions. Indeed, while internal layers remain essentially under-vulcanized, external coating is always over-vulcanized, resulting in an overall average tensile strength insufficient to permit the utilization of the items in several applications where it is required a certain level of performance. Possible ways to improve rubber output mechanical properties include a careful calibration of exposition time and curing temperature in traditional heating or a vulcanization through innovative techniques, such as microwaves. In the present paper, a comprehensive numerical model able to give predictions on the optimized final mechanical properties of vulcanized 2D and 3D thick rubber items is presented and applied to a meaningful example of engineering interest. A detailed comparative numerical study is finally presented in order to establish pros and cons of traditional vulcanization vs microwaves curing.

Real-time Retrieving Atmospheric Parameters from Multi-GNSS Constellations

NASA Astrophysics Data System (ADS)

Li, X.; Zus, F.; Lu, C.; Dick, G.; Ge, M.; Wickert, J.; Schuh, H.

2016-12-01

The multi-constellation GNSS (e.g. GPS, GLONASS, Galileo, and BeiDou) bring great opportunities and challenges for real-time retrieval of atmospheric parameters for supporting numerical weather prediction (NWP) nowcasting or severe weather event monitoring. In this study, the observations from different GNSS are combined together for atmospheric parameter retrieving based on the real-time precise point positioning technique. The atmospheric parameters retrieved from multi-GNSS observations, including zenith total delay (ZTD), integrated water vapor (IWV), horizontal gradient (especially high-resolution gradient estimates) and slant total delay (STD), are carefully analyzed and evaluated by using the VLBI, radiosonde, water vapor radiometer and numerical weather model to independently validate the performance of individual GNSS and also demonstrate the benefits of multi-constellation GNSS for real-time atmospheric monitoring. Numerous results show that the multi-GNSS processing can provide real-time atmospheric products with higher accuracy, stronger reliability and better distribution, which would be beneficial for atmospheric sounding systems, especially for nowcasting of extreme weather.

Recent Advances in Application of Biosensors in Tissue Engineering

PubMed Central

Paul, Arghya; Lee, Yong-kyu; Jaffa, Ayad A.

2014-01-01

Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications. PMID:25165697

Numerical Investigation of Flow in a Centrifugal Compressor

NASA Astrophysics Data System (ADS)

Grishin, Yu. A.; Bakulin, V. N.

2015-09-01

With the use of the domestic software suite of computational hydrodynamics Flow Vision based on application of the method of control volumes, numerical simulation of air composition and delivery by a centrifugal compressor employed for supercharging a piston engine has been carried out. The head-flow characteristics of the compressor, as well as the 3D fields of flow velocity and pressure distributions in the elements of the compressor flow passage, including the interblade channels of the impeller, have been obtained for various regimes. In the regimes of diminished air flow rate, surging phenomena are identified, characterized by a return flow. The application of the technique of numerical experiment will make it possible from here on to carry out design optimization of the compressor flow passage profile and thus to improve its basic characteristics — the degree of pressure increase, compressed air flow rate, and the efficiency — as well as to reduce the costs of the development and production of compressors.

Recent advances in application of biosensors in tissue engineering.

PubMed

Hasan, Anwarul; Nurunnabi, Md; Morshed, Mahboob; Paul, Arghya; Polini, Alessandro; Kuila, Tapas; Al Hariri, Moustafa; Lee, Yong-kyu; Jaffa, Ayad A

2014-01-01

Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.

The global alcohol industry: an overview.

PubMed

Jernigan, David H

2009-02-01

To describe the globalized sector of the alcoholic beverage industry, including its size, principal actors and activities. Market research firms and business journalism are the primary sources for information about the global alcohol industry, and are used to profile the size and membership of the three main industry sectors of beer, distilled spirits and wine. Branded alcoholic beverages are approximately 38% of recorded alcohol consumption world-wide. Producers of these beverages tend to be large multi-national corporations reliant on marketing for their survival. Marketing activities include traditional advertising as well as numerous other activities, such as new product development, product placement and the creation and promotion of social responsibility programs, messages and organizations. The global alcohol industry is highly concentrated and innovative. There is relatively little public health research evaluating the impact of its many marketing activities.

Higgs Boson Pair Production in Gluon Fusion at Next-to-Leading Order with Full Top-Quark Mass Dependence.

PubMed

Borowka, S; Greiner, N; Heinrich, G; Jones, S P; Kerner, M; Schlenk, J; Schubert, U; Zirke, T

2016-07-01

We present the calculation of the cross section and invariant mass distribution for Higgs boson pair production in gluon fusion at next-to-leading order (NLO) in QCD. Top-quark masses are fully taken into account throughout the calculation. The virtual two-loop amplitude has been generated using an extension of the program GoSam supplemented with an interface to Reduze for the integral reduction. The occurring integrals have been calculated numerically using the program SecDec. Our results, including the full top-quark mass dependence for the first time, allow us to assess the validity of various approximations proposed in the literature, which we also recalculate. We find substantial deviations between the NLO result and the different approximations, which emphasizes the importance of including the full top-quark mass dependence at NLO.

Biodiesel production with microalgae as feedstock: from strains to biodiesel.

PubMed

Gong, Yangmin; Jiang, Mulan

2011-07-01

Due to negative environmental influence and limited availability, petroleum-derived fuels need to be replaced by renewable biofuels. Biodiesel has attracted intensive attention as an important biofuel. Microalgae have numerous advantages for biodiesel production over many terrestrial plants. There are a series of consecutive processes for biodiesel production with microalgae as feedstock, including selection of adequate microalgal strains, mass culture, cell harvesting, oil extraction and transesterification. To reduce the overall production cost, technology development and process optimization are necessary. Genetic engineering also plays an important role in manipulating lipid biosynthesis in microalgae. Many approaches, such as sequestering carbon dioxide from industrial plants for the carbon source, using wastewater for the nutrient supply, and maximizing the values of by-products, have shown a potential for cost reduction. This review provides a brief overview of the process of biodiesel production with microalgae as feedstock. The methods associated with this process (e.g. lipid determination, mass culture, oil extraction) are also compared and discussed.

Control and Diagnosis in Integrated Product Development - Observations during the Development of an AGV

NASA Astrophysics Data System (ADS)

Stetter, R.; Simundsson, A.

2015-11-01

This paper is concerned with the integration of control and diagnosis functionalities into the development of complete systems which include mechanical, electrical and electronic subsystems. For the development of such systems the strategies, methods and tools of integrated product development have attracted significant attention during the last decades. Today, it is generally observed that product development processes of complex systems can only be successful if the activities in the different domains are well connected and synchronised and if an ongoing communication is present - an ongoing communication spanning the technical domains and also including functions such as production planning, marketing/distribution, quality assurance, service and project planning. Obviously, numerous approaches to tackle this challenge are present in scientific literature and in industrial practice, as well. Today, the functionality and safety of most products is to a large degree dependent on control and diagnosis functionalities. Still, there is comparatively little research concentrating on the integration of the development of these functionalities into the overall product development processes. The main source of insight of the presented research is the product development process of an Automated Guided Vehicle (AGV) which is intended to be used on rough terrain. The paper starts with a background describing Integrated Product Development. The second section deals with the product development of the sample product. The third part summarizes some insights and formulates first hypotheses concerning control and diagnosis in Integrated Product Development.

Experimental and Numerical Observations of Hydrate Reformation during Depressurization in a Core-Scale Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seol, Yongkoo; Myshakin, Evgeniy

2011-01-01

Gas hydrate has been predicted to reform around a wellbore during depressurization-based gas production from gas hydrate-bearing reservoirs. This process has an adverse effect on gas production rates and it requires time and sometimes special measures to resume gas flow to producing wells. Due to lack of applicable field data, laboratory scale experiments remain a valuable source of information to study hydrate reformation. In this work, we report laboratory experiments and complementary numerical simulations executed to investigate the hydrate reformation phenomenon. Gas production from a pressure vessel filled with hydrate-bearing sand was induced by depressurization with and without heat fluxmore » through the boundaries. Hydrate decomposition was monitored with a medical X-ray CT scanner and pressure and temperature measurements. CT images of the hydrate-bearing sample were processed to provide 3-dimensional data of heterogeneous porosity and phase saturations suitable for numerical simulations. In the experiments, gas hydrate reformation was observed only in the case of no-heat supply from surroundings, a finding consistent with numerical simulation. By allowing gas production on either side of the core, numerical simulations showed that initial hydrate distribution patterns affect gas distribution and flow inside the sample. This is a direct consequence of the heterogeneous pore network resulting in varying hydraulic properties of the hydrate-bearing sediment.« less

Applications of Nonenzymatic Catalysts to the Alteration of Natural Products.

PubMed

Shugrue, Christopher R; Miller, Scott J

2017-09-27

The application of small molecules as catalysts for the diversification of natural product scaffolds is reviewed. Specifically, principles that relate to the selectivity challenges intrinsic to complex molecular scaffolds are summarized. The synthesis of analogues of natural products by this approach is then described as a quintessential "late-stage functionalization" exercise wherein natural products serve as the lead scaffolds. Given the historical application of enzymatic catalysts to the site-selective alteration of complex molecules, the focus of this Review is on the recent studies of nonenzymatic catalysts. Reactions involving hydroxyl group derivatization with a variety of electrophilic reagents are discussed. C-H bond functionalizations that lead to oxidations, aminations, and halogenations are also presented. Several examples of site-selective olefin functionalizations and C-C bond formations are also included. Numerous classes of natural products have been subjected to these studies of site-selective alteration including polyketides, glycopeptides, terpenoids, macrolides, alkaloids, carbohydrates, and others. What emerges is a platform for chemical remodeling of naturally occurring scaffolds that targets virtually all known chemical functionalities and microenvironments. However, challenges for the design of very broad classes of catalysts, with even broader selectivity demands (e.g., stereoselectivity, functional group selectivity, and site-selectivity) persist. Yet, a significant spectrum of powerful, catalytic alterations of complex natural products now exists such that expansion of scope seems inevitable. Several instances of biological activity assays of remodeled natural product derivatives are also presented. These reports may foreshadow further interdisciplinary impacts for catalytic remodeling of natural products, including contributions to SAR development, mode of action studies, and eventually medicinal chemistry.

Retailer Stackelberg game in a supply chain with pricing and service decisions and simple price discount contract

PubMed Central

Sadjadi, Seyed Jafar; Sadeghian, Ramin; Sahebi, Hadi

2018-01-01

This paper studies the Retailer Stackelberg game in a supply chain consisting of two manufacturers and one retailer where they compete simultaneously under three factors including price, service and simple price discount contract. It is assumed that the second manufacturer provides service directly to his customers, and the retailer provides service for the first product’s customers, while the retailer buys the first product under price discount from the first manufacturer. The analysis of the optimal equilibrium solutions and the results of the numerical examples show that if a manufacturer chooses the appropriate range of discount rate, he will gain more profit than when there is no discount given to the retailer. This situation can be considered as an effective tool for the coordination of the first manufacturer and the retailer to offer discount by manufacturer and to provide the service by the retailer. We obtain equilibrium solution of Retailer Stackelberg game and analyze the numerical examples under two cases: a) the manufacturers sell their products to the retailer without price discount contract. b) The first manufacturer sells his products to the retailer with the simple price discount contract. The preliminary results show that the service and the price discount contract can improve the performance of supply chain. PMID:29649315

Risk assessment of consuming agricultural products irrigated with reclaimed wastewater: An exposure model

NASA Astrophysics Data System (ADS)

van Ginneken, Meike; Oron, Gideon

2000-09-01

This study assesses health risks to consumers due to the use of agricultural products irrigated with reclaimed wastewater. The analysis is based on a definition of an exposure model which takes into account several parameters: (1) the quality of the applied wastewater, (2) the irrigation method, (3) the elapsed times between irrigation, harvest, and product consumption, and (4) the consumers' habits. The exposure model is used for numerical simulation of human consumers' risks using the Monte Carlo simulation method. The results of the numerical simulation show large deviations, probably caused by uncertainty (impreciseness in quality of input data) and variability due to diversity among populations. There is a 10-orders of magnitude difference in the risk of infection between the different exposure scenarios with the same water quality. This variation indicates the need for setting risk-based criteria for wastewater reclamation rather than single water quality guidelines. Extra data are required to decrease uncertainty in the risk assessment. Future research needs to include definition of acceptable risk criteria, more accurate dose-response modeling, information regarding pathogen survival in treated wastewater, additional data related to the passage of pathogens into and in the plants during irrigation, and information regarding the behavior patterns of the community of human consumers.

Genome editing in plants: Advancing crop transformation and overview of tools.

PubMed

Shah, Tariq; Andleeb, Tayyaba; Lateef, Sadia; Noor, Mehmood Ali

2018-05-07

Genome manipulation technology is one of emerging field which brings real revolution in genetic engineering and biotechnology. Targeted editing of genomes pave path to address a wide range of goals not only to improve quality and productivity of crops but also permit to investigate the fundamental roots of biological systems. These goals includes creation of plants with valued compositional properties and with characters that confer resistance to numerous biotic and abiotic stresses. Numerous novel genome editing systems have been introduced during the past few years; these comprise zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9). Genome editing technique is consistent for improving average yield to achieve the growing demands of the world's existing food famine and to launch a feasible and environmentally safe agriculture scheme, to more specific, productive, cost-effective and eco-friendly. These exciting novel methods, concisely reviewed herein, have verified themselves as efficient and reliable tools for the genetic improvement of plants. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Coupled-Double-Quantum-Dot Environmental Information Engines: A Numerical Analysis

NASA Astrophysics Data System (ADS)

Tanabe, Katsuaki

2016-06-01

We conduct numerical simulations for an autonomous information engine comprising a set of coupled double quantum dots using a simple model. The steady-state entropy production rate in each component, heat and electron transfer rates are calculated via the probability distribution of the four electronic states from the master transition-rate equations. We define an information-engine efficiency based on the entropy change of the reservoir, implicating power generators that employ the environmental order as a new energy resource. We acquire device-design principles, toward the realization of corresponding practical energy converters, including that (1) higher energy levels of the detector-side reservoir than those of the detector dot provide significantly higher work production rates by faster states' circulation, (2) the efficiency is strongly dependent on the relative temperatures of the detector and system sides and becomes high in a particular Coulomb-interaction strength region between the quantum dots, and (3) the efficiency depends little on the system dot's energy level relative to its reservoir but largely on the antisymmetric relative amplitudes of the electronic tunneling rates.

Investigation of instability of displacement front in non-isothermal flow problems

NASA Astrophysics Data System (ADS)

Syulyukina, Natalia; Pergament, Anna

2012-11-01

In this paper, we investigate the issues of front instability arising in non-isothermal flow displacement processes. The problem of two-phase flow of immiscible fluids, oil and water, is considered, including sources and dependence of viscosity on temperature. Three-dimensional problem with perturbation close to the injection well was considered to find the characteristic scale of the instability. As a result of numerical calculations, theoretical studies on the development of the instability due to the fact that the viscosity of the displacing fluid is less than the viscosity of the displaced have been confirmed. The influence of temperature on the evolution of the instability was considered. For this purpose, the dependence of oil viscosity on temperature has been added to the problem. Numerical calculations were carried out for different values of temperature and it was shown that with increasing of production rate. Thus, it has been demonstrated that the selection of the optimal temperature for injected fluids a possible way for stimulation of oil production also delaying the field water-flooding. This work was supporting by the RFBR grant 12-01-00793-a.

DNA Repair in Drosophila: Mutagens, Models, and Missing Genes

PubMed Central

Sekelsky, Jeff

2017-01-01

The numerous processes that damage DNA are counterbalanced by a complex network of repair pathways that, collectively, can mend diverse types of damage. Insights into these pathways have come from studies in many different organisms, including Drosophila melanogaster. Indeed, the first ideas about chromosome and gene repair grew out of Drosophila research on the properties of mutations produced by ionizing radiation and mustard gas. Numerous methods have been developed to take advantage of Drosophila genetic tools to elucidate repair processes in whole animals, organs, tissues, and cells. These studies have led to the discovery of key DNA repair pathways, including synthesis-dependent strand annealing, and DNA polymerase theta-mediated end joining. Drosophila appear to utilize other major repair pathways as well, such as base excision repair, nucleotide excision repair, mismatch repair, and interstrand crosslink repair. In a surprising number of cases, however, DNA repair genes whose products play important roles in these pathways in other organisms are missing from the Drosophila genome, raising interesting questions for continued investigations. PMID:28154196

Wind Power Ramping Product for Increasing Power System Flexibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Mingjian; Zhang, Jie; Wu, Hongyu

With increasing penetrations of wind power, system operators are concerned about a potential lack of system flexibility and ramping capacity in real-time dispatch stages. In this paper, a modified dispatch formulation is proposed considering the wind power ramping product (WPRP). A swinging door algorithm (SDA) and dynamic programming are combined and used to detect WPRPs in the next scheduling periods. The detected WPRPs are included in the unit commitment (UC) formulation considering ramping capacity limits, active power limits, and flexible ramping requirements. The modified formulation is solved by mixed integer linear programming. Numerical simulations on a modified PJM 5-bus Systemmore » show the effectiveness of the model considering WPRP, which not only reduces the production cost but also does not affect the generation schedules of thermal units.« less

Mathematical models of the simplest fuzzy PI/PD controllers with skewed input and output fuzzy sets.

PubMed

Mohan, B M; Sinha, Arpita

2008-07-01

This paper unveils mathematical models for fuzzy PI/PD controllers which employ two skewed fuzzy sets for each of the two-input variables and three skewed fuzzy sets for the output variable. The basic constituents of these models are Gamma-type and L-type membership functions for each input, trapezoidal/triangular membership functions for output, intersection/algebraic product triangular norm, maximum/drastic sum triangular conorm, Mamdani minimum/Larsen product/drastic product inference method, and center of sums defuzzification method. The existing simplest fuzzy PI/PD controller structures derived via symmetrical fuzzy sets become special cases of the mathematical models revealed in this paper. Finally, a numerical example along with its simulation results are included to demonstrate the effectiveness of the simplest fuzzy PI controllers.

Applications of the bacteriocin, nisin.

PubMed

Delves-Broughton, J; Blackburn, P; Evans, R J; Hugenholtz, J

1996-02-01

Nisin was first introduced commercially as a food preservative in the UK approximately 30 years ago. First established use was as a preservative in processed cheese products and since then numerous other applications in foods and beverages have been identified. It is currently recognised as a safe food preservative in approximately 50 countries. The established uses of nisin as a preservative in processed cheese, various pasteurised dairy products, and canned vegetables will be briefly reviewed. More recent applications of nisin include its use as a preservative in high moisture, hot baked flour products (crumpets) and pasteurised liquid egg. Renewed interest is evident in the use of nisin in natural cheese production. Considerable research has been carried out on the antilisterial properties of nisin in foods and a number of applications have been proposed. Uses of nisin to control spoilage lactic acid bacteria have been identified in beer, wine, alcohol production and low pH foods such as salad dressings. Further developments of nisin are likely to include synergistic action of nisin with chelators and other bacteriocins, and its use as an adjunct in novel food processing technology such as higher pressure sterilisation and electroporation. Production of highly purified nisin preparations and enhancement by chelators has led to interest in the use of nisin for human ulcer therapy, and mastitis control in cattle.

Industrial Technology Modernization Program. Project 32. Factory Vision. Phase 2

DTIC Science & Technology

1988-04-01

instructions for the PWA’s, generating the numerical control (NC) program instructions for factory assembly equipment, controlling the process... generating the numerical control (NC) program instructions for factory assembly equipment, controlling the production process instructions and NC... Assembly Operations the "Create Production Process Program" will automatically generate a sequence of graphics pages (in paper mode), or graphics screens

Macrocyclic drugs and synthetic methodologies toward macrocycles

PubMed Central

Yu, Xufen; Sun, Dianqing

2015-01-01

Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products. Over the last several decades, numerous efforts have been undertaken toward the synthesis of complex naturally occurring macrocycles and great progresses have been made to advance the field of total synthesis. The commonly used synthetic methodologies toward macrocyclization include macrolactonization, macrolactamization, transition metal-catalyzed cross coupling, ring-closing metathesis, and click reaction, among others. Selected recent examples of macrocyclic synthesis of natural products and druglike macrocycles with significant biological relevance are highlighted in each class. The primary goal of this review is to summarize currently used macrocyclic drugs, highlight the therapeutic potential of this underexplored drug class and outline the general synthetic methodologies for the synthesis of macrocycles. PMID:23708234

Dynamic analysis, circuit implementation and passive control of a novel four-dimensional chaotic system with multiscroll attractor and multiple coexisting attractors

NASA Astrophysics Data System (ADS)

Lai, Bang-Cheng; He, Jian-Jun

2018-03-01

In this paper, we construct a novel 4D autonomous chaotic system with four cross-product nonlinear terms and five equilibria. The multiple coexisting attractors and the multiscroll attractor of the system are numerically investigated. Research results show that the system has various types of multiple attractors, including three strange attractors with a limit cycle, three limit cycles, two strange attractors with a pair of limit cycles, two coexisting strange attractors. By using the passive control theory, a controller is designed for controlling the chaos of the system. Both analytical and numerical studies verify that the designed controller can suppress chaotic motion and stabilise the system at the origin. Moreover, an electronic circuit is presented for implementing the chaotic system.

Tensor-product preconditioners for higher-order space-time discontinuous Galerkin methods

NASA Astrophysics Data System (ADS)

Diosady, Laslo T.; Murman, Scott M.

2017-02-01

A space-time discontinuous-Galerkin spectral-element discretization is presented for direct numerical simulation of the compressible Navier-Stokes equations. An efficient solution technique based on a matrix-free Newton-Krylov method is developed in order to overcome the stiffness associated with high solution order. The use of tensor-product basis functions is key to maintaining efficiency at high-order. Efficient preconditioning methods are presented which can take advantage of the tensor-product formulation. A diagonalized Alternating-Direction-Implicit (ADI) scheme is extended to the space-time discontinuous Galerkin discretization. A new preconditioner for the compressible Euler/Navier-Stokes equations based on the fast-diagonalization method is also presented. Numerical results demonstrate the effectiveness of these preconditioners for the direct numerical simulation of subsonic turbulent flows.

Tensor-Product Preconditioners for Higher-Order Space-Time Discontinuous Galerkin Methods

NASA Technical Reports Server (NTRS)

Diosady, Laslo T.; Murman, Scott M.

2016-01-01

space-time discontinuous-Galerkin spectral-element discretization is presented for direct numerical simulation of the compressible Navier-Stokes equat ions. An efficient solution technique based on a matrix-free Newton-Krylov method is developed in order to overcome the stiffness associated with high solution order. The use of tensor-product basis functions is key to maintaining efficiency at high order. Efficient preconditioning methods are presented which can take advantage of the tensor-product formulation. A diagonalized Alternating-Direction-Implicit (ADI) scheme is extended to the space-time discontinuous Galerkin discretization. A new preconditioner for the compressible Euler/Navier-Stokes equations based on the fast-diagonalization method is also presented. Numerical results demonstrate the effectiveness of these preconditioners for the direct numerical simulation of subsonic turbulent flows.

Biogenic organic emissions, air quality and climate

NASA Astrophysics Data System (ADS)

Guenther, A. B.

2015-12-01

Living organisms produce copious amounts of a diverse array of metabolites including many volatile organic compounds that are released into the atmosphere. These compounds participate in numerous chemical reactions that influence the atmospheric abundance of important air pollutants and short-lived climate forcers including organic aerosol, ozone and methane. The production and release of these organics are strongly influenced by environmental conditions including air pollution, temperature, solar radiation, and water availability and they are highly sensitive to stress and extreme events. As a result, releases of biogenic organics to the atmosphere have an impact on, and are sensitive to, air quality and climate leading to potential feedback couplings. Their role in linking air quality and climate is conceptually clear but an accurate quantitative representation is needed for predictive models. Progress towards this goal will be presented including numerical model development and assessments of the predictive capability of the Model of Emission of Gases and Aerosols from Nature (MEGAN). Recent studies of processes controlling the magnitude and variations in biogenic organic emissions will be described and observations of their impact on atmospheric composition will be shown. Recent advances and priorities for future research will be discussed including laboratory process studies, long-term measurements, multi-scale regional studies, global satellite observations, and the development of a next generation model for simulating land-atmosphere chemical exchange.

Computationally efficient modeling and simulation of large scale systems

NASA Technical Reports Server (NTRS)

Jain, Jitesh (Inventor); Cauley, Stephen F. (Inventor); Li, Hong (Inventor); Koh, Cheng-Kok (Inventor); Balakrishnan, Venkataramanan (Inventor)

2010-01-01

A method of simulating operation of a VLSI interconnect structure having capacitive and inductive coupling between nodes thereof. A matrix X and a matrix Y containing different combinations of passive circuit element values for the interconnect structure are obtained where the element values for each matrix include inductance L and inverse capacitance P. An adjacency matrix A associated with the interconnect structure is obtained. Numerical integration is used to solve first and second equations, each including as a factor the product of the inverse matrix X.sup.1 and at least one other matrix, with first equation including X.sup.1Y, X.sup.1A, and X.sup.1P, and the second equation including X.sup.1A and X.sup.1P.

Modeling pore corrosion in normally open gold- plated copper connectors.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Battaile, Corbett Chandler; Moffat, Harry K.; Sun, Amy Cha-Tien

2008-09-01

The goal of this study is to model the electrical response of gold plated copper electrical contacts exposed to a mixed flowing gas stream consisting of air containing 10 ppb H{sub 2}S at 30 C and a relative humidity of 70%. This environment accelerates the attack normally observed in a light industrial environment (essentially a simplified version of the Battelle Class 2 environment). Corrosion rates were quantified by measuring the corrosion site density, size distribution, and the macroscopic electrical resistance of the aged surface as a function of exposure time. A pore corrosion numerical model was used to predict bothmore » the growth of copper sulfide corrosion product which blooms through defects in the gold layer and the resulting electrical contact resistance of the aged surface. Assumptions about the distribution of defects in the noble metal plating and the mechanism for how corrosion blooms affect electrical contact resistance were needed to complete the numerical model. Comparisons are made to the experimentally observed number density of corrosion sites, the size distribution of corrosion product blooms, and the cumulative probability distribution of the electrical contact resistance. Experimentally, the bloom site density increases as a function of time, whereas the bloom size distribution remains relatively independent of time. These two effects are included in the numerical model by adding a corrosion initiation probability proportional to the surface area along with a probability for bloom-growth extinction proportional to the corrosion product bloom volume. The cumulative probability distribution of electrical resistance becomes skewed as exposure time increases. While the electrical contact resistance increases as a function of time for a fraction of the bloom population, the median value remains relatively unchanged. In order to model this behavior, the resistance calculated for large blooms has been weighted more heavily.« less

Development of a numerical methodology for flowforming process simulation of complex geometry tubes

NASA Astrophysics Data System (ADS)

Varela, Sonia; Santos, Maite; Arroyo, Amaia; Pérez, Iñaki; Puigjaner, Joan Francesc; Puigjaner, Blanca

2017-10-01

Nowadays, the incremental flowforming process is widely explored because of the usage of complex tubular products is increasing due to the light-weighting trend and the use of expensive materials. The enhanced mechanical properties of finished parts combined with the process efficiency in terms of raw material and energy consumption are the key factors for its competitiveness and sustainability, which is consistent with EU industry policy. As a promising technology, additional steps for extending the existing flowforming limits in the production of tubular products are required. The objective of the present research is to further expand the current state of the art regarding limitations on tube thickness and diameter, exploring the feasibility to flowform complex geometries as tubes of elevated thickness of up to 60 mm. In this study, the analysis of the backward flowforming process of 7075 aluminum tubular preform is carried out to define the optimum process parameters, machine requirements and tooling geometry as demonstration case. Numerical simulation studies on flowforming of thin walled tubular components have been considered to increase the knowledge of the technology. The calculation of the rotational movement of the mesh preform, the high ratio thickness/length and the thermomechanical condition increase significantly the computation time of the numerical simulation model. This means that efficient and reliable tools able to predict the forming loads and the quality of flowformed thick tubes are not available. This paper aims to overcome this situation by developing a simulation methodology based on FEM simulation code including new strategies. Material characterization has also been performed through tensile test to able to design the process. Finally, to check the reliability of the model, flowforming tests at industrial environment have been developed.

Evaluation of strategies to communicate harmful and potentially harmful constituent (HPHC) information through cigarette package inserts: a discrete choice experiment.

PubMed

Salloum, Ramzi G; Louviere, Jordan J; Getz, Kayla R; Islam, Farahnaz; Anshari, Dien; Cho, Yoojin; O'Connor, Richard J; Hammond, David; Thrasher, James F

2017-07-13

The US Food and Drug Administration (FDA) has regulatory authority to use inserts to communicate with consumers about harmful and potentially harmful constituents (HPHCs) in tobacco products; however, little is known about the most effective manner for presenting HPHC information. In a discrete choice experiment, participants evaluated eight choice sets, each of which showed two cigarette packages from four different brands and tar levels (high vs low), accompanied by an insert that included between-subject manipulations (ie, listing of HPHCs vs grouping by disease outcome and numeric values ascribed to HPHCs vs no numbers) and within-subject manipulations (ie, 1 of 4 warning topics; statement linking an HPHC with disease vs statement with no HPHC link). For each choice set, participants were asked: (1) which package is more harmful and (2) which motivates them to not smoke; each with a 'no difference' option. Alternative-specific logit models regressed choice on attribute levels. 1212 participants were recruited from an online consumer panel (725 18-29-year-old smokers and susceptible non-smokers and 487 30-64-year-old smokers). Participants were more likely to endorse high-tar products as more harmful than low-tar products, with a greater effect when numeric HPHC information was present. Compared with a simple warning statement, the statement linking HPHCs with disease encouraged quit motivation. Numeric HPHC information on inserts appears to produce misunderstandings that some cigarettes are less harmful than others. Furthermore, brief narratives that link HPHCs to smoking-related disease may promote cessation versus communications that do not explicitly link HPHCs to disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

ACOG Committee Opinion Number 542: Access to emergency contraception.

PubMed

2012-11-01

Emergency contraception includes contraceptive methods used to prevent pregnancy in the first few days after unprotected intercourse, sexual assault, or contraceptive failure. Although the U.S. Food and Drug Administration approved the first dedicated product for emergency contraception in 1998, numerous barriers to access to emergency contraception remain. The purpose of this Committee Opinion is to examine the barriers to the use of oral emergency contraception methods and to highlight the importance of increasing access.

Flood Plain Information Bushkill Creek, Vicinity of Easton, Pennsylvania.

DTIC Science & Technology

1972-01-01

is a cement plant and numerous railroad sidings in the Borough of Stockertown. Further down- stream, in the Borough of Tatamy , development includes...several production and storage facirities and the local fire department. Below Tatamy , development again consists of scat- tered residential and...23,000 Bridge Bushkill St. Bridge 7.1 7,200 17,000 ( Tatamy , Pa.) Lehigh Valley R.R. 8.2 7,200 17,000 Bridge (Stockertown, Pa.) 8th Street Bridge 8.5

Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water

PubMed Central

Miller, Todd R.; Beversdorf, Lucas J.; Weirich, Chelsea A.; Bartlett, Sarah L.

2017-01-01

Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments across the planet. Seasonally, they dominate many eutrophic lakes impacted by excess nitrogen (N) and phosphorus (P) forming dense accumulations of biomass known as cyanobacterial harmful algal blooms or cyanoHABs. Their dominance in eutrophic lakes is attributed to a variety of unique adaptations including N and P concentrating mechanisms, N2 fixation, colony formation that inhibits predation, vertical movement via gas vesicles, and the production of toxic or otherwise bioactive molecules. While some of these molecules have been explored for their medicinal benefits, others are potent toxins harmful to humans, animals, and other wildlife known as cyanotoxins. In humans these cyanotoxins affect various tissues, including the liver, central and peripheral nervous system, kidneys, and reproductive organs among others. They induce acute effects at low doses in the parts-per-billion range and some are tumor promoters linked to chronic diseases such as liver and colorectal cancer. The occurrence of cyanoHABs and cyanotoxins in lakes presents challenges for maintaining safe recreational aquatic environments and the production of potable drinking water. CyanoHABs are a growing problem in the North American (Laurentian) Great Lakes basin. This review summarizes information on the occurrence of cyanoHABs in the Great Lakes, toxicological effects of cyanotoxins, and appropriate numerical limits on cyanotoxins in finished drinking water. PMID:28574457

Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water.

PubMed

Miller, Todd R; Beversdorf, Lucas J; Weirich, Chelsea A; Bartlett, Sarah L

2017-06-02

Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments across the planet. Seasonally, they dominate many eutrophic lakes impacted by excess nitrogen (N) and phosphorus (P) forming dense accumulations of biomass known as cyanobacterial harmful algal blooms or cyanoHABs. Their dominance in eutrophic lakes is attributed to a variety of unique adaptations including N and P concentrating mechanisms, N₂ fixation, colony formation that inhibits predation, vertical movement via gas vesicles, and the production of toxic or otherwise bioactive molecules. While some of these molecules have been explored for their medicinal benefits, others are potent toxins harmful to humans, animals, and other wildlife known as cyanotoxins. In humans these cyanotoxins affect various tissues, including the liver, central and peripheral nervous system, kidneys, and reproductive organs among others. They induce acute effects at low doses in the parts-per-billion range and some are tumor promoters linked to chronic diseases such as liver and colorectal cancer. The occurrence of cyanoHABs and cyanotoxins in lakes presents challenges for maintaining safe recreational aquatic environments and the production of potable drinking water. CyanoHABs are a growing problem in the North American (Laurentian) Great Lakes basin. This review summarizes information on the occurrence of cyanoHABs in the Great Lakes, toxicological effects of cyanotoxins, and appropriate numerical limits on cyanotoxins in finished drinking water.

Recent Enhancements in NOAA's JPSS Land Product Suite and Key Operational Applications

NASA Astrophysics Data System (ADS)

Csiszar, I. A.; Yu, Y.; Zhan, X.; Vargas, M.; Ek, M. B.; Zheng, W.; Wu, Y.; Smirnova, T. G.; Benjamin, S.; Ahmadov, R.; James, E.; Grell, G. A.

2017-12-01

A suite of operational land products has been produced as part of NOAA's Joint Polar Satellite System (JPSS) program to support a wide range of operational applications in environmental monitoring, prediction, disaster management and mitigation, and decision support. The Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi National Polar-orbiting Partnership (NPP) and the operational JPSS satellite series forms the basis of six fundamental and multiple additional added-value environmental data records (EDRs). A major recent improvement in the land-based VIIRS EDRs has been the development of global gridded products, providing a format and science content suitable for ingest into NOAA's operational land surface and coupled numerical weather prediction models. VIIRS near-real-time Green Vegetation Fraction is now in the process of testing for full operational use, while land surface temperature and albedo are under testing and evaluation. The operational 750m VIIRS active fire product, including fire radiative power, is used to support emission modeling and air quality applications. Testing the evaluation for operational NOAA implementation of the improved 375m VIIRS active fire product is also underway. Added-value and emerging VIIRS land products include vegetation health, phenology, near-real-time surface type and surface condition change, and other biogeophysical variables. As part of the JPSS program, a global soil moisture data product has also been generated from the Advanced Microwave Scanning Radiometer 2 (AMSR2) sensor on the GCOM-W1 (Global Change Observation Mission - Water 1) satellite since July 2012. This product is included in the blended NESDIS Soil Moisture Operational Products System, providing soil moisture data as a critical input for land surface modeling.

Numeric Data Products and Services. SPEC Kit.

ERIC Educational Resources Information Center

Cook, Michael N., Comp.; Hernandez, John J., Comp.; Nicholson, Shawn, Comp.

2001-01-01

This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries. The survey addressed the following questions about numeric data (i.e., any information resource, print or non-print, with considerable numeric content) in academic libraries: (1) What relationships…

A Fast Numerical Method for Max-Convolution and the Application to Efficient Max-Product Inference in Bayesian Networks.

PubMed

Serang, Oliver

2015-08-01

Observations depending on sums of random variables are common throughout many fields; however, no efficient solution is currently known for performing max-product inference on these sums of general discrete distributions (max-product inference can be used to obtain maximum a posteriori estimates). The limiting step to max-product inference is the max-convolution problem (sometimes presented in log-transformed form and denoted as "infimal convolution," "min-convolution," or "convolution on the tropical semiring"), for which no O(k log(k)) method is currently known. Presented here is an O(k log(k)) numerical method for estimating the max-convolution of two nonnegative vectors (e.g., two probability mass functions), where k is the length of the larger vector. This numerical max-convolution method is then demonstrated by performing fast max-product inference on a convolution tree, a data structure for performing fast inference given information on the sum of n discrete random variables in O(nk log(nk)log(n)) steps (where each random variable has an arbitrary prior distribution on k contiguous possible states). The numerical max-convolution method can be applied to specialized classes of hidden Markov models to reduce the runtime of computing the Viterbi path from nk(2) to nk log(k), and has potential application to the all-pairs shortest paths problem.

Kranc: a Mathematica package to generate numerical codes for tensorial evolution equations

NASA Astrophysics Data System (ADS)

Husa, Sascha; Hinder, Ian; Lechner, Christiane

2006-06-01

We present a suite of Mathematica-based computer-algebra packages, termed "Kranc", which comprise a toolbox to convert certain (tensorial) systems of partial differential evolution equations to parallelized C or Fortran code for solving initial boundary value problems. Kranc can be used as a "rapid prototyping" system for physicists or mathematicians handling very complicated systems of partial differential equations, but through integration into the Cactus computational toolkit we can also produce efficient parallelized production codes. Our work is motivated by the field of numerical relativity, where Kranc is used as a research tool by the authors. In this paper we describe the design and implementation of both the Mathematica packages and the resulting code, we discuss some example applications, and provide results on the performance of an example numerical code for the Einstein equations. Program summaryTitle of program: Kranc Catalogue identifier: ADXS_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADXS_v1_0 Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Distribution format: tar.gz Computer for which the program is designed and others on which it has been tested: General computers which run Mathematica (for code generation) and Cactus (for numerical simulations), tested under Linux Programming language used: Mathematica, C, Fortran 90 Memory required to execute with typical data: This depends on the number of variables and gridsize, the included ADM example requires 4308 KB Has the code been vectorized or parallelized: The code is parallelized based on the Cactus framework. Number of bytes in distributed program, including test data, etc.: 1 578 142 Number of lines in distributed program, including test data, etc.: 11 711 Nature of physical problem: Solution of partial differential equations in three space dimensions, which are formulated as an initial value problem. In particular, the program is geared towards handling very complex tensorial equations as they appear, e.g., in numerical relativity. The worked out examples comprise the Klein-Gordon equations, the Maxwell equations, and the ADM formulation of the Einstein equations. Method of solution: The method of numerical solution is finite differencing and method of lines time integration, the numerical code is generated through a high level Mathematica interface. Restrictions on the complexity of the program: Typical numerical relativity applications will contain up to several dozen evolution variables and thousands of source terms, Cactus applications have shown scaling up to several thousand processors and grid sizes exceeding 500 3. Typical running time: This depends on the number of variables and the grid size: the included ADM example takes approximately 100 seconds on a 1600 MHz Intel Pentium M processor. Unusual features of the program: based on Mathematica and Cactus

Maximizing the accuracy of field-derived numeric nutrient criteria in water quality regulations.

PubMed

McLaughlin, Douglas B

2014-01-01

High levels of the nutrients nitrogen and phosphorus can cause unhealthy biological or ecological conditions in surface waters and prevent the attainment of their designated uses. Regulatory agencies are developing numeric criteria for these nutrients in an effort to ensure that the surface waters in their jurisdictions remain healthy and productive, and that water quality standards are met. These criteria are often derived using field measurements that relate nutrient concentrations and other water quality conditions to expected biological responses such as undesirable growth or changes in aquatic plant and animal communities. Ideally, these numeric criteria can be used to accurately "diagnose" ecosystem health and guide management decisions. However, the degree to which numeric nutrient criteria are useful for decision making depends on how accurately they reflect the status or risk of nutrient-related biological impairments. Numeric criteria that have little predictive value are not likely to be useful for managing nutrient concerns. This paper presents information on the role of numeric nutrient criteria as biological health indicators, and the potential benefits of sufficiently accurate criteria for nutrient management. In addition, it describes approaches being proposed or adopted in states such as Florida and Maine to improve the accuracy of numeric criteria and criteria-based decisions. This includes a preference for developing site-specific criteria in cases where sufficient data are available, and the use of nutrient concentration and biological response criteria together in a framework to support designated use attainment decisions. Together with systematic planning during criteria development, the accuracy of field-derived numeric nutrient criteria can be assessed and maximized as a part of an overall effort to manage nutrient water quality concerns. © 2013 SETAC.

Fifteen Years after “Wingspread”—Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go

PubMed Central

Hotchkiss, Andrew K.; Rider, Cynthia V.; Blystone, Chad R.; Wilson, Vickie S.; Hartig, Phillip C.; Ankley, Gerald T.; Foster, Paul M.; Gray, Clark L.; Gray, L. Earl

2008-01-01

In 1991, a group of expert scientists at a Wingspread work session on endocrine-disrupting chemicals (EDCs) concluded that “Many compounds introduced into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Endocrine disruption can be profound because of the crucial role hormones play in controlling development.” Since that time, there have been numerous documented examples of adverse effects of EDCs in invertebrates, fish, wildlife, domestic animals, and humans. Hormonal systems can be disrupted by numerous different anthropogenic chemicals including antiandrogens, androgens, estrogens, AhR agonists, inhibitors of steroid hormone synthesis, antithyroid substances, and retinoid agonists. In addition, pathways and targets for endocrine disruption extend beyond the traditional estrogen/androgen/thyroid receptor–mediated reproductive and developmental systems. For example, scientists have expressed concern about the potential role of EDCs in increasing trends in early puberty in girls, obesity and type II diabetes in the United States and other populations. New concerns include complex endocrine alterations induced by mixtures of chemicals, an issue broadened due to the growing awareness that EDCs present in the environment include a variety of potent human and veterinary pharmaceutical products, personal care products, nutraceuticals and phytosterols. In this review we (1) address what have we learned about the effects of EDCs on fish, wildlife, and human health, (2) discuss representative animal studies on (anti)androgens, estrogens and 2,3,7,8-tetrachlorodibenzo-p-dioxin–like chemicals, and (3) evaluate regulatory proposals being considered for screening and testing these chemicals. PMID:18281716

Developmental specialization in the right intraparietal sulcus for the abstract representation of numerical magnitude.

PubMed

Holloway, Ian D; Ansari, Daniel

2010-11-01

Because number is an abstract quality of a set, the way in which a number is externally represented does not change its quantitative meaning. In this study, we examined the development of the brain regions that support format-independent representation of numerical magnitude. We asked children and adults to perform both symbolic (Hindu-Arabic numerals) and nonsymbolic (arrays of squares) numerical comparison tasks as well as two control tasks while their brains were scanned using fMRI. In a preliminary analysis, we calculated the conjunction between symbolic and nonsymbolic numerical comparison. We then examined in which brain regions this conjunction differed between children and adults. This analysis revealed a large network of visual and parietal regions that showed greater activation in adults relative to children. In our primary analysis, we examined age-related differences in the conjunction of symbolic and nonsymbolic comparison after subtracting the control tasks. This analysis revealed a much more limited set of regions including the right inferior parietal lobe near the intraparietal sulcus. In addition to showing increased activation to both symbolic and nonsymbolic magnitudes over and above activation related to response selection, this region showed age-related differences in the distance effect. Our findings demonstrate that the format-independent representation of numerical magnitude in the right inferior parietal lobe is the product of developmental processes of cortical specialization and highlight the importance of using appropriate control tasks when conducting developmental neuroimaging studies.

Resolving the chemical structures of off-odorants and potentially harmful substances in toys-example of children's swords.

PubMed

Denk, Philipp; Velasco-Schön, Cristina; Buettner, Andrea

2017-09-01

Most children's toys on the market are primarily made out of plastic and other complex composite materials. Consumer complaints about offensive odors or irritating effects associated with toy products have increased in recent years. One example is the strongly perceivable negative odor reported for a particular series of toy swords. Characterizing the presence of contaminants, including those that have the potential to be deleterious to health, in such products is a significant analytical challenge due to the high baseline abundance of chemical constituents of the materials used in the products. In the present study, the nature of offensive odorants associated with toy sword products was examined by gas chromatography (GC). After initial sensory evaluations, the volatile compounds from the toy products were recovered using solvent extraction and solvent-assisted flavor evaporation. The extracts were analyzed using GC-olfactometry (GC-O) and two-dimensional GC-O coupled with mass spectrometry (GC-GC-MS/O). A total of 26 odor-active compounds, including aromatic hydrocarbons and phenols, were identified among numerous non-odorous volatile by-products. These substances also included polycyclic aromatic hydrocarbons, which were analyzed by GC-MS. Representative substances were naphthalene and 1,2-dihydronaphthalene that exhibited moldy, mothball-like odor impressions, and phenol derivatives with leather-like, phenolic, horse-stable-like smells. The odorants detected correlated with the assigned attributes from the sensory analyses. This study clearly shows that the detection and identification of such odorous contaminants can provide key indications of potentially harmful yet unknown substances in everyday products such as toys. Graphical abstract ᅟ.

Operational System-Impact Products for the Space Situational Awareness Environmental Effects Fusion System (SEEFS)

NASA Astrophysics Data System (ADS)

Quigley, S.; Scro, K.

2006-12-01

The Space Vehicles Directorate of the Air Force Research Laboratory (AFRL/VSBX) and the Technology Applications Division of the Space and Missile Systems Center (SMC/WXT) have combined efforts under the Rapid Prototyping Center (RPC) to design, develop, test, implement, and validate numerical and graphical products for the Air Force Space Command (AFSPC) Space Situational Awareness Environmental Effects Fusion System (SEEFS). These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense weapons, navigation, communications, and surveillance systems. Jointly developed projects that have been completed as prototypes and are undergoing development for real-time operations include a SEEFS architecture and database, five system-impact products, and a high-level decision aid product. This first round of SEEFS products includes Solar Radio Burst Effects (SoRBE) on radar and satellite communications, Radar Auroral Clutter (RAC), Scintillation Effects on radar and satellite communications (RadScint and SatScint), and Satellite Surface and Deep Charge/Discharge (Char/D). The SEEFS architecture and database enable modular use and execution of SEEFS products, and the high-level Decision Aid shows the combined effects of all SEEFS product output on a given asset and on multi-asset missions. This presentation provides a general overview of the SEEFS program, along with details of the first round of products expected to be operational for use in exercises and/or real-time operations in 2007-2008.

Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies.

PubMed

Abbasalizadeh, Saeed; Baharvand, Hossein

2013-12-01

Recent technological advances in the generation, characterization, and bioprocessing of human pluripotent stem cells (hPSCs) have created new hope for their use as a source for production of cell-based therapeutic products. To date, a few clinical trials that have used therapeutic cells derived from hESCs have been approved by the Food and Drug Administration (FDA), but numerous new hPSC-based cell therapy products are under various stages of development in cell therapy-specialized companies and their future market is estimated to be very promising. However, the multitude of critical challenges regarding different aspects of hPSC-based therapeutic product manufacturing and their therapies have made progress for the introduction of new products and clinical applications very slow. These challenges include scientific, technological, clinical, policy, and financial aspects. The technological aspects of manufacturing hPSC-based therapeutic products for allogeneic and autologous cell therapies according to good manufacturing practice (cGMP) quality requirements is one of the most important challenging and emerging topics in the development of new hPSCs for clinical use. In this review, we describe main critical challenges and highlight a series of technological advances in all aspects of hPSC-based therapeutic product manufacturing including clinical grade cell line development, large-scale banking, upstream processing, downstream processing, and quality assessment of final cell therapeutic products that have brought hPSCs closer to clinical application and commercial cGMP manufacturing. © 2013.

Monitoring the tobacco use epidemic II. The Agent: Current and Emerging Tobacco Products

PubMed Central

Stellman, Steven D.; Djordjevic, Mirjana V.

2009-01-01

Objective This Agent paper summarizes the findings and recommendations of the Agent (product) Working Group of the November, 2002, National Tobacco Monitoring, Research and Evaluation Workshop. Methods The Agent Working Group evaluated the need to develop new surveillance systems for quantifying ingredients and emissions of tobacco and tobacco smoke and to improve methods to assess uptake and metabolism of these constituents taking into account variability in human smoking behavior. Results The toxic properties of numerous tobacco and tobacco smoke constituents are well known, yet systematic monitoring of tobacco products has historically been limited to tar, nicotine, and CO in mainstream cigarette smoke using a machine-smoking protocol that does not reflect human smoking behavior. Toxicity of smokeless tobacco products has not been regularly monitored. Tobacco products are constantly changing and untested products are introduced into the marketplace with great frequency, including potential reduced-exposure products (PREPs). The public health impact of new or modified tobacco products is unknown. Conclusions Systematic surveillance is recommended for mainstream smoke constituents such as polycyclic aromatic hydrocarbons (PAH), tobacco-specific nitrosamines (TSNA), total and free-base nicotine, volatile organic compounds, aromatic amines, and metals; and design attributes including tobacco blend, additives, and filter ventilation. Research on smoking topography is recommended to help define machine-smoking protocols for monitoring emissions reflective of human smoking behavior. Recommendations are made for marketplace product sampling and for population monitoring of smoking topography, emissions of toxic constituents, biomarkers of exposure and, eventually, risk of tobacco-related diseases. PMID:18848577

Value-Engineering Review for Numerical Control

NASA Technical Reports Server (NTRS)

Warner, J. L.

1984-01-01

Selecting parts for conversion from conventional machining to numerical control, value-engineering review performed for every part to identify potential changes to part design that result in increased production efficiency.

High-Resolution Mass Spectrometric Analysis of Secondary Organic Aerosol Produced by Ozonation of Limonene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walser, Maggie L.; Dessiaterik, Yury; Laskin, Julia

2008-02-08

Secondary organic aerosol (SOA) particles formed from the ozone-initiated oxidation of limonene are characterized by high-resolution electrospray ionization mass spectrometry in both the positive and negative ion modes. The mass spectra reveal a large number of both monomeric (m/z < 300) and oligomeric (m/z > 300) products of oxidation. A combination of high resolving power (m/Δm ~60,000) and Kendrick mass defect analysis makes it possible to unambiguously determine the composition for hundreds of individual compounds in SOA samples. Van Krevelen analysis shows that the SOA compounds are heavily oxidized, with average O:C ratios of 0.43 and 0.50 determined from themore » positive and negative ion mode spectra, respectively. An extended reaction mechanism for the formation of the first generation SOA molecular components is proposed. The mechanism includes known isomerization and addition reactions of the carbonyl oxide intermediates generated during the ozonation of limonene, and numerous isomerization pathways for alkoxy radicals resulting from the decomposition of unstable carbonyl oxides. The isomerization reactions yield numerous products with a progressively increasing number of alcohol and carbonyl groups, whereas C-C bond scission reactions in alkoxy radicals shorten the carbon chain. Together these reactions yield a large number of isomeric products with broadly distributed masses. A qualitative agreement is found between the number and degree of oxidation of the predicted and measured reaction products in the monomer range.« less

Ignition kinetics of boron in primary combustion products of propellant based on its unique characteristics

NASA Astrophysics Data System (ADS)

Ao, Wen; Wang, Yang; Wu, Shixi

2017-07-01

Study on the boron-based primary combustion products can bridge the gap between primary combustion and secondary combustion in solid rocket ramjets. To clarify the initial state and ignition characteristics of boron particles in the after-burning chamber of solid rocket ramjets, the elemental, composition and morphology of the primary combustion products collected under gas generator chamber pressure of 0.2 MPa and 6 MPa were investigated by energy dispersive (EDS), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy with energy dispersive (SEM-EDS) individually. The ignition times of boron particles among the primary combustion products were determined using a high temperature tube furnace system. The BD model was adopted for numerical verification. The numerical solution procedure of boron ignition model in a real afterburner chamber was modified. The results show that the sum of B, C, O elements in the primary combustion products reaches approximately 90%. The primary combustion products are mainly consisted of B, C, and B2O3. Images of the primary combustion products present highly agglomeration, indicating an oxidation of boron surface. Numerous spherical carbon particles with a diameter around 100 nm are observed in the products. Three features of the boron in the primary combustion products are obtained, compared to virgin boron. First most of the boron lumps are covered by carbon particles on the surface. Second the mean particle size is five times larger than that of virgin boron. Third the overall initial oxide layer covered on boron surface increases its thickness by above 0.1 μm. The ignition time of boron in the primary combustion products reaches 20-30 ms under 1673-1873 K, which is quite different from virgin boron of 4 ms. Numerical calculation results show the key reason leading to such a long ignition time is the variation of the initial oxide layer thickness. In conclusion, the physicochemical properties of boron particles are found to differ with virgin boron after primary combustion process. The accurate evaluation of the initial oxide layer thickness and initial particle radius is a crucial procedure before the numerical calculation of boron ignition kinetics. Results of our study are expected to provide better insight in the simulation of solid rocket ramjets working process.

Recovery Processes of Organic Acids from Fermentation Broths in the Biomass-Based Industry.

PubMed

Li, Qian-Zhu; Jiang, Xing-Lin; Feng, Xin-Jun; Wang, Ji-Ming; Sun, Chao; Zhang, Hai-Bo; Xian, Mo; Liu, Hui-Zhou

2016-01-01

The new movement towards green chemistry and renewable feedstocks makes microbial production of chemicals more competitive. Among the numerous chemicals, organic acids are more attractive targets for process development efforts in the renewable-based biorefinery industry. However, most of the production costs in microbial processes are higher than that in chemical processes, among which over 60% are generated by separation processes. Therefore, the research of separation and purification processes is important for a promising biorefinery industry. This review highlights the progress of recovery processes in the separation and purification of organic acids, including their advantages and disadvantages, current situation, and future prospects in terms of recovery yields and industrial application.

[Oxygen and the superoxide anion. Modulation of NADPH oxidase?].

PubMed

Delbosc, S; Cristol, J P; Descomps, B; Chénard, J; Sirois, P

2001-01-01

Oxidative stress which results from an imbalance between oxidant production and antioxidant defense mechanisms can promote modifications of lipids, proteins and nucleic acids. This review focuses on the different pathways leading to Reactive Oxygen Species (ROS) production in particular on NADPH oxidase activation. This enzyme is localized in numerous cells including phagocytes and vascular cells and composed of membrane and cytosolic sub-units. The activation of the NADPH oxidase is largely involved in inflammation associated diseases such as asthma, Systemic Inflammatory Response Syndrome and aging associated diseases such as atherosclerosis and neurodeneratives diseases. The modulation of NADPH oxidase could be a way to limit or prevent the development of these diseases.

Does products liability litigation threaten picture archiving and communication systems and/or telemedicine?

PubMed

McMenamin, J P

1998-02-01

Numerous writers have commented on barriers to the growth and progress of telemedicine. Among these barriers are reimbursement concerns, professional liability exposure, licensing restrictions, hospital credentialing questions, and other problems. A legal threat not generally described in the literature to date is the possibility that products liability claims could be brought against manufacturers and distributors of hardware, software, and peripherals used in providing telemedicine services. Several of these concerns extend to picture archiving and communication systems (PACS), including, of course, teleradiology. This article considers that possibility in the context of several potential plaintiffs' theories, discusses currently applicable law, and proposes approaches to diminishing the magnitude and severity of this potential threat.

Cathodic electrocatalyst layer for electrochemical generation of hydrogen peroxide

NASA Technical Reports Server (NTRS)

Tennakoon, Charles L. K. (Inventor); Singh, Waheguru Pal (Inventor); Rhodes, Christopher P. (Inventor); Anderson, Kelvin C. (Inventor)

2011-01-01

A cathodic gas diffusion electrode for the electrochemical production of aqueous hydrogen peroxide solutions. The cathodic gas diffusion electrode comprises an electrically conductive gas diffusion substrate and a cathodic electrocatalyst layer supported on the gas diffusion substrate. A novel cathodic electrocatalyst layer comprises a cathodic electrocatalyst, a substantially water-insoluble quaternary ammonium compound, a fluorocarbon polymer hydrophobic agent and binder, and a perfluoronated sulphonic acid polymer. An electrochemical cell using the novel cathodic electrocatalyst layer has been shown to produce an aqueous solution having between 8 and 14 weight percent hydrogen peroxide. Furthermore, such electrochemical cells have shown stable production of hydrogen peroxide solutions over 1000 hours of operation including numerous system shutdowns.

Observation of extremely strong shock waves in solids launched by petawatt laser heating

DOE PAGES

Lancaster, K. L.; Robinson, A. P. L.; Pasley, J.; ...

2017-08-25

Understanding hydrodynamic phenomena driven by fast electron heating is important for a range of applications including fast electron collimation schemes for fast ignition and the production and study of hot, dense matter. In this work, detailed numerical simulations modelling the heating, hydrodynamic evolution, and extreme ultra-violet (XUV) emission in combination with experimental XUV images indicate shock waves of exceptional strength (200 Mbar) launched due to rapid heating of materials via a petawatt laser. In conclusion, we discuss in detail the production of synthetic XUV images and how they assist us in interpreting experimental XUV images captured at 256 eV usingmore » a multi-layer spherical mirror.« less

Engineering hurdles in contact and intraocular lens lathe design: the view ahead

NASA Astrophysics Data System (ADS)

Bradley, Norman D.; Keller, John R.; Ball, Gary A.

1994-05-01

Current trends in and intraocular lens design suggest ever- increasing demand for aspheric lens geometries - multisurface and/or toric surfaces - in a variety of new materials. As computer numeric controls (CNC) lathes and mills continue to evolve with he ophthalmic market, engineering hurdles present themselves to designers: Can hardware based upon single-point diamond turning accommodate the demands of software-driven designs? What are the limits of CNC resolution and repeatability in high-throughput production? What are the controlling factors in lathed, polish-free surface production? Emerging technologies in the lathed biomedical optics field are discussed along with their limitations, including refined diamond tooling, vibrational control, automation, and advanced motion control systems.

A Study of Two-Equation Turbulence Models on the Elliptic Streamline Flow

NASA Technical Reports Server (NTRS)

Blaisdell, Gregory A.; Qin, Jim H.; Shariff, Karim; Rai, Man Mohan (Technical Monitor)

1995-01-01

Several two-equation turbulence models are compared to data from direct numerical simulations (DNS) of the homogeneous elliptic streamline flow, which combines rotation and strain. The models considered include standard two-equation models and models with corrections for rotational effects. Most of the rotational corrections modify the dissipation rate equation to account for the reduced dissipation rate in rotating turbulent flows, however, the DNS data shows that the production term in the turbulent kinetic energy equation is not modeled correctly by these models. Nonlinear relations for the Reynolds stresses are considered as a means of modifying the production term. Implications for the modeling of turbulent vortices will be discussed.

Diverse Applications of Electronic-Nose Technologies in Agriculture and Forestry

PubMed Central

Wilson, Alphus D.

2013-01-01

Electronic-nose (e-nose) instruments, derived from numerous types of aroma-sensor technologies, have been developed for a diversity of applications in the broad fields of agriculture and forestry. Recent advances in e-nose technologies within the plant sciences, including improvements in gas-sensor designs, innovations in data analysis and pattern-recognition algorithms, and progress in material science and systems integration methods, have led to significant benefits to both industries. Electronic noses have been used in a variety of commercial agricultural-related industries, including the agricultural sectors of agronomy, biochemical processing, botany, cell culture, plant cultivar selections, environmental monitoring, horticulture, pesticide detection, plant physiology and pathology. Applications in forestry include uses in chemotaxonomy, log tracking, wood and paper processing, forest management, forest health protection, and waste management. These aroma-detection applications have improved plant-based product attributes, quality, uniformity, and consistency in ways that have increased the efficiency and effectiveness of production and manufacturing processes. This paper provides a comprehensive review and summary of a broad range of electronic-nose technologies and applications, developed specifically for the agriculture and forestry industries over the past thirty years, which have offered solutions that have greatly improved worldwide agricultural and agroforestry production systems. PMID:23396191

Diverse applications of electronic-nose technologies in agriculture and forestry.

PubMed

Wilson, Alphus D

2013-02-08

Electronic-nose (e-nose) instruments, derived from numerous types of aroma-sensor technologies, have been developed for a diversity of applications in the broad fields of agriculture and forestry. Recent advances in e-nose technologies within the plant sciences, including improvements in gas-sensor designs, innovations in data analysis and pattern-recognition algorithms, and progress in material science and systems integration methods, have led to significant benefits to both industries. Electronic noses have been used in a variety of commercial agricultural-related industries, including the agricultural sectors of agronomy, biochemical processing, botany, cell culture, plant cultivar selections, environmental monitoring, horticulture, pesticide detection, plant physiology and pathology. Applications in forestry include uses in chemotaxonomy, log tracking, wood and paper processing, forest management, forest health protection, and waste management. These aroma-detection applications have improved plant-based product attributes, quality, uniformity, and consistency in ways that have increased the efficiency and effectiveness of production and manufacturing processes. This paper provides a comprehensive review and summary of a broad range of electronic-nose technologies and applications, developed specifically for the agriculture and forestry industries over the past thirty years, which have offered solutions that have greatly improved worldwide agricultural and agroforestry production systems.

Ingredient and labeling issues associated with allergenic foods.

PubMed

Taylor, S L; Hefle, S L

2001-01-01

Foods contain a wide range of food ingredients that serve numerous technical functions. Per capita consumer exposure to most of these food ingredients is rather low with a few notable exceptions such as sugar and starch. Some food ingredients including edible oils, hydrolyzed proteins, lecithin, starch, lactose, flavors and gelatin may, at least in some products, be derived from sources commonly involved in IgE-mediated food allergies. These ingredients should be avoided by consumers with allergies to the source material if the ingredient contains detectable protein residues. Other food ingredients, including starch, malt, alcohol and vinegar, may be derived in some cases from wheat, rye or barley, the grains that are implicated in the causation of celiac disease. If these ingredients contain gluten residues, then they should be avoided by celiac sufferers. A few food ingredients are capable of eliciting allergic sensitization, although these ingredients would be classified as rarely allergenic. These ingredients include carmine, cochineal extract, annatto, tragacanth gum and papain. Food manufacturers should declare the presence of allergenic food ingredients in the ingredient listings on product labels so that allergic consumers can know to avoid these potentially hazardous products.

Mathematical modeling of methyl ester concentration distribution in a continuous membrane tubular reactor and comparison with conventional tubular reactor

NASA Astrophysics Data System (ADS)

Talaghat, M. R.; Jokar, S. M.; Modarres, E.

2017-10-01

The reduction of fossil fuel resources and environmental issues made researchers find alternative fuels include biodiesels. One of the most widely used methods for production of biodiesel on a commercial scale is transesterification method. In this work, the biodiesel production by a transesterification method was modeled. Sodium hydroxide was considered as a catalyst to produce biodiesel from canola oil and methanol in a continuous tubular ceramic membranes reactor. As the Biodiesel production reaction from triglycerides is an equilibrium reaction, the reaction rate constants depend on temperature and related linearly to catalyst concentration. By using the mass balance for a membrane tubular reactor and considering the variation of raw materials and products concentration with time, the set of governing equations were solved by numerical methods. The results clearly show the superiority of membrane reactor than conventional tubular reactors. Afterward, the influences of molar ratio of alcohol to oil, weight percentage of the catalyst, and residence time on the performance of biodiesel production reactor were investigated.

Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid.

PubMed

Cao, Mingfeng; Feng, Jun; Sirisansaneeyakul, Sarote; Song, Cunjiang; Chisti, Yusuf

2018-05-28

Poly-γ-glutamic acid (γ-PGA) is a natural biopolymer of glutamic acid. The repeating units of γ-PGA may be derived exclusively from d-glutamic acid, or l-glutamic acid, or both. The monomer units are linked by amide bonds between the α-amino group and the γ-carboxylic acid group. γ-PGA is biodegradable, edible and water-soluble. It has numerous existing and emerging applications in processing of foods, medicines and cosmetics. This review focuses on microbial production of γ-PGA via genetically and metabolically engineered recombinant bacteria. Strategies for improving production of γ-PGA include modification of its biosynthesis pathway, enhancing the production of its precursor (glutamic acid), and preventing loss of the precursor to competing byproducts. These and other strategies are discussed. Heterologous synthesis of γ-PGA in industrial bacterial hosts that do not naturally produce γ-PGA is discussed. Emerging trends and the challenges affecting the production of γ-PGA are reviewed. Copyright © 2018. Published by Elsevier Inc.

Modeling of plant in vitro cultures: overview and estimation of biotechnological processes.

PubMed

Maschke, Rüdiger W; Geipel, Katja; Bley, Thomas

2015-01-01

Plant cell and tissue cultivations are of growing interest for the production of structurally complex and expensive plant-derived products, especially in pharmaceutical production. Problems with up-scaling, low yields, and high-priced process conditions result in an increased demand for models to provide comprehension, simulation, and optimization of production processes. In the last 25 years, many models have evolved in plant biotechnology; the majority of them are specialized models for a few selected products or nutritional conditions. In this article we review, delineate, and discuss the concepts and characteristics of the most commonly used models. Therefore, the authors focus on models for plant suspension and submerged hairy root cultures. The article includes a short overview of modeling and mathematics and integrated parameters, as well as the application scope for each model. The review is meant to help researchers better understand and utilize the numerous models published for plant cultures, and to select the most suitable model for their purposes. © 2014 Wiley Periodicals, Inc.

Open source Matrix Product States: Opening ways to simulate entangled many-body quantum systems in one dimension

NASA Astrophysics Data System (ADS)

Jaschke, Daniel; Wall, Michael L.; Carr, Lincoln D.

2018-04-01

Numerical simulations are a powerful tool to study quantum systems beyond exactly solvable systems lacking an analytic expression. For one-dimensional entangled quantum systems, tensor network methods, amongst them Matrix Product States (MPSs), have attracted interest from different fields of quantum physics ranging from solid state systems to quantum simulators and quantum computing. Our open source MPS code provides the community with a toolset to analyze the statics and dynamics of one-dimensional quantum systems. Here, we present our open source library, Open Source Matrix Product States (OSMPS), of MPS methods implemented in Python and Fortran2003. The library includes tools for ground state calculation and excited states via the variational ansatz. We also support ground states for infinite systems with translational invariance. Dynamics are simulated with different algorithms, including three algorithms with support for long-range interactions. Convenient features include built-in support for fermionic systems and number conservation with rotational U(1) and discrete Z2 symmetries for finite systems, as well as data parallelism with MPI. We explain the principles and techniques used in this library along with examples of how to efficiently use the general interfaces to analyze the Ising and Bose-Hubbard models. This description includes the preparation of simulations as well as dispatching and post-processing of them.

From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics.

PubMed

Silber, Johanna; Kramer, Annemarie; Labes, Antje; Tasdemir, Deniz

2016-07-21

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics.

Remedial action suitability for the Cornhusker Army Ammunition Plant site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nonavinakere, S.; Rappa, P. III

1995-12-31

Numerous Department of Defense (DOD) sites across the nation are contaminated with explosive wastes due to munitions production during World War II, Korean Conflict and Vietnam Conflict. Production activities included explosives manufacturing, loading, packing, assembling, machining, casting and curing. Contaminants often present at these sites include TNT, RDX, HMX, Tetryl 2,4-DNT, 2,6-DNT, 1,3-DNB, 1,3,5-TNB and nitrobenzene. The Cornhusker Army Ammunition Plant (CAAP) is one such DOD site that has been determined to be contaminated with explosives. The CAAP is located approximately 2 miles west of the City of Grand Island in Hall County, Nebraska. The plant produced artillery, bombs, boosters,more » supplementary charges and various other experimental explosives. The purpose of this paper is to provide an overview of the site background, review of the remedial alternatives evaluation process and rationale behind the selection of present remedial action.« less

The unity of the fundamental interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zichichi, A.

1983-01-01

This book offers a collection of authoritative papers which provides the reader with a plenary survey of some of the latest developments in the field of high-energy interactions. The contributing physicists offer a comprehensive review of recent significant findings from both theoretical and experimental studies in high-energy interactions. Topics include the end of the high-energy frontier, monopoles, numerical studies of gauge field theories, expectations for the next generation of experiments, unified models, cosmology, supersymmetry, neutrino physics at Fermilab, heavy flavor production in the highest-energy (pp) interactions, b-quark physics, hadron production in e/sup +/e/sup -/ annihilation, the search for new particlesmore » and electroweak interference effects in e/sup +/e/sup -/ interactions, CP violation, and high-energy soft (pp) interactions. Includes essays by Edward Teller and P.A.M. Dirac on their lives as physicists, and one by E.P. Wigner on ''the glorious days of physics.''« less

Biological and biomedical aspects of genetically modified food.

PubMed

Celec, Peter; Kukucková, Martina; Renczésová, Veronika; Natarajan, Satheesh; Pálffy, Roland; Gardlík, Roman; Hodosy, Július; Behuliak, Michal; Vlková, Barbora; Minárik, Gabriel; Szemes, Tomás; Stuchlík, Stanislav; Turna, Ján

2005-12-01

Genetically modified (GM) foods are the product of one of the most progressive fields of science-biotechnology. There are major concerns about GM foods in the public; some of them are reasonable, some of them are not. Biomedical risks of GM foods include problems regarding the potential allergenicity, horizontal gene transfer, but environmental side effects on biodiversity must also be recognized. Numerous methods have been developed to assess the potential risk of every GM food type. Benefits of the first generation of GM foods were oriented towards the production process and companies, the second generation of GM foods offers, on contrary, various advantages and added value for the consumer. This includes improved nutritional composition or even therapeutic effects. Recombinant probiotics and the principle of alternative gene therapy represent the latest approach of using GM organisms for biomedical applications. This article tries to summarize and to explain the problematic topic of GM food.

Space-Time Dependent Transport, Activation, and Dose Rates for Radioactivated Fluids.

NASA Astrophysics Data System (ADS)

Gavazza, Sergio

Two methods are developed to calculate the space - and time-dependent mass transport of radionuclides, their production and decay, and the associated dose rates generated from the radioactivated fluids flowing through pipes. The work couples space- and time-dependent phenomena, treated as only space- or time-dependent in the open literature. The transport and activation methodology (TAM) is used to numerically calculate space- and time-dependent transport and activation of radionuclides in fluids flowing through pipes exposed to radiation fields, and volumetric radioactive sources created by radionuclide motions. The computer program Radionuclide Activation and Transport in Pipe (RNATPA1) performs the numerical calculations required in TAM. The gamma ray dose methodology (GAM) is used to numerically calculate space- and time-dependent gamma ray dose equivalent rates from the volumetric radioactive sources determined by TAM. The computer program Gamma Ray Dose Equivalent Rate (GRDOSER) performs the numerical calculations required in GAM. The scope of conditions considered by TAM and GAM herein include (a) laminar flow in straight pipe, (b)recirculating flow schemes, (c) time-independent fluid velocity distributions, (d) space-dependent monoenergetic neutron flux distribution, (e) space- and time-dependent activation process of a single parent nuclide and transport and decay of a single daughter radionuclide, and (f) assessment of space- and time-dependent gamma ray dose rates, outside the pipe, generated by the space- and time-dependent source term distributions inside of it. The methodologies, however, can be easily extended to include all the situations of interest for solving the phenomena addressed in this dissertation. A comparison is made from results obtained by the described calculational procedures with analytical expressions. The physics of the problems addressed by the new technique and the increased accuracy versus non -space and time-dependent methods are presented. The value of the methods is also discussed. It has been demonstrated that TAM and GAM can be used to enhance the understanding of the space- and time-dependent mass transport of radionuclides, their production and decay, and the associated dose rates related to radioactivated fluids flowing through pipes.

Numerical studies on alpha production from high energy proton beam interaction with Boron

NASA Astrophysics Data System (ADS)

Moustaizis, S. D.; Lalousis, P.; Hora, H.; Korn, G.

2017-05-01

Numerical investigations on high energy proton beam interaction with high density Boron plasma allows to simulate conditions concerning the alpha production from recent experimental measurements . The experiments measure the alpha production due to p11B nuclear fusion reactions when a laser-driven high energy proton beam interacts with Boron plasma produced by laser beam interaction with solid Boron. The alpha production and consequently the efficiency of the process depends on the initial proton beam energy, proton beam density, the Boron plasma density and temperature, and their temporal evolution. The main advantage for the p11B nuclear fusion reaction is the production of three alphas with total energy of 8.9 MeV, which could enhance the alpha heating effect and improve the alpha production. This particular effect is termed in the international literature as the alpha avalanche effect. Numerical results using a multi-fluid, global particle and energy balance, code shows the alpha production efficiency as a function of the initial energy of the proton beam, the Boron plasma density, the initial Boron plasma temperature and the temporal evolution of the plasma parameters. The simulations enable us to determine the interaction conditions (proton beam - B plasma) for which the alpha heating effect becomes important.

Internal ballistics of the detonation products of a blast-hole charge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mangush, S.K.; Garbunov, V.A.

1986-07-01

The authors investigate the gasdynamic flow of the detonation products of a blast-hole charge (the expansion of the detonation products in the blast hole and the gas outflow and propagation of shock airwaves into the face space). The problem is solved by means of a numerical program for integration of partial differential equations of one-dimensional gas-dynamics. A numerical model of the internal ballistics of a blast-hole charge is presented. In addition to the variation of the thermodynamic parameters in the blast hole, the formation of the shock wave in the face space is shown, which is the source of gasmore » ignition. Further development of the numerical model of the action of blast-hole charges is planned which will involve an analysis of a number of applied problems.« less

Epigenetics and developmental programming of welfare and production traits in farm animals.

PubMed

Sinclair, K D; Rutherford, K M D; Wallace, J M; Brameld, J M; Stöger, R; Alberio, R; Sweetman, D; Gardner, D S; Perry, V E A; Adam, C L; Ashworth, C J; Robinson, J E; Dwyer, C M

2016-07-21

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

Getting beyond hand-waving about microsites with numerical representations of trace gas production and consumption

NASA Astrophysics Data System (ADS)

Sihi, D.; Davidson, E. A.; Savage, K. E.; Liang, D.

2017-12-01

Production and consumption of nitrous oxide (N2O), methane (CH4), and carbon dioxide (CO2) are affected by complex interactions of temperature, moisture, and substrate supply, that is further complicated by spatial heterogeneity of the soil matrix. This microsite heterogeneity is often invoked conceptually to explain unusual observations like consumption of atmospheric N2O (reduction) in upland soils that co-occur with CH4 uptake (oxidation). To advance numerical simulation of these belowground processes, we expanded the Dual Arrhenius and Michaelis-Menten (DAMM) model, to apply it consistently for all three greenhouse gases (GHGs) with respect to the biophysical processes of production, consumption, and diffusion within the soil, including the contrasting effects of oxygen (O2) as substrate or inhibitor for each process. Chamber-based measurements of all three GHGs at the Howland Forest (ME, USA) were used to parameterize the model. The area under a soil chamber is partitioned according to a bivariate lognormal probability distribution function of soil carbon (C) and moisture across a range of microsites, that leads to a distribution of heterotrophic respiration and O2 consumption among microsites. Linking microsite consumption of O2 with a diffusion model generates a broad range of microsite concentrations of O2 that determines the distribution of microsites that produce or consume CH4 and N2O, such that a range of microsite concentrations occur both above and below ambient values for both GHGs. At lower mean soil moisture, some microsites of methanogenesis still occur, but most become sites of methanotrophy. Likewise, concentrations of below ambient N2O (hotspots of N2O reduction) occur in microsites with high C and high moisture (further accentuated at high temperature). Net consumption and production of CH4 and N2O is simulated within a chamber based on the sum of the distribution of soil microsites. Results demonstrate that it is numerically feasible for microsites of N2O reduction and CH4 oxidation to co-occur under a single chamber. Simultaneous simulation of all three GHGs in a parsimonious modeling framework is challenging but affords confidence that agreement between simulations and measurements is based on skillful numerical representation of processes across a heterogeneous environment.

Optimal pricing and marketing planning for deteriorating items.

PubMed

Moosavi Tabatabaei, Seyed Reza; Sadjadi, Seyed Jafar; Makui, Ahmad

2017-01-01

Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and after-sales service expenditures. The proposed model is formulated as a geometric programming with 5 degrees of difficulty and the problem is solved using the recent advances in optimization techniques. The study is supported by several numerical examples and sensitivity analysis is performed to analyze the effects of the changes in different parameters on the optimal solution. The preliminary results indicate that with the change in parameters influencing on demand, inventory holding, inventory deteriorating and set-up costs change and also significantly affect total revenue.

Virtual prototyping of drop test using explicit analysis

NASA Astrophysics Data System (ADS)

Todorov, Georgi; Kamberov, Konstantin

2017-12-01

Increased requirements for reliability and safety, included in contemporary standards and norms, has high impact over new product development. New numerical techniques based on virtual prototyping technology, facilitates imrpoving product development cycle, resutling in reduced time/money spent for this stage as well as increased knowledge about certain failure mechanism. So called "drop test" became nearly a "must" step in development of any human operated product. This study aims to demonstrate dynamic behaviour assessment of a structure under impact loads, based on virtual prototyping using a typical nonlinear analysis - explicit dynamics. An example is presneted, based on a plastic container that is used as cartridge for a dispenser machine exposed to various work conditions. Different drop orientations were analyzed and critical load cases and design weaknesses have been found. Several design modifications have been proposed, based on detailed analyses results review.

Accumulation of organic compounds leached from plastic materials used in biopharmaceutical process containers.

PubMed

Jenke, Dennis R; Zietlow, David; Garber, Mary Jo; Sadain, Salma; Reiber, Duane; Terbush, William

2007-01-01

Plastic materials are widely used in medical items, such as solution containers, transfusion sets, transfer tubing, and devices. An emerging trend in the biotechnology industry is the utilization of plastic containers to prepare, transport, and store an assortment of solutions including buffers, media, and in-process and finished product. The direct contact of such containers with the product at one or more points in its lifetime raises the possibility that container leachables may accumulate in the finished product. The interaction between several commercially available container materials and numerous model test solutions (representative of buffers and media used in biopharmaceutical applications) was investigated. This paper summarizes the identification of leachables associated with the container materials and documents the levels to which targeted leachables accumulate in the test solutions under defined storage conditions.

Synthesis and dynamic 1H NMR study of pyrazolo substituted pyrrolo[2,3-d]pyrimidines via a regioselective heterocyclization

NASA Astrophysics Data System (ADS)

Bayat, Mohammad; Nasri, Shima

2018-02-01

A new series of pyrrolo[2,3-d]pyrimidine derivatives substituted with pyrazolone were designed and prepared, by the three-component reaction of pyrazolone derivatives, arylglyoxal and 6-aminouracil derivatives in ethanol at reflux. The direction of heterocyclization has confirmed and the structure of final products were identified spectroscopically (IR, 1H- and 13C-NMR, and EI-MS). The significant advantages of this protocol include simplicity, regioselectivity, existence of numerous hydrogen bonding possibilities in product, good yields and catalyst-free approach. When the uracil is 6-amino-1,3-dimethyluracil, the product exists as two tautomers at room temperature. The dynamic NMR effects are observed in the 1H NMR spectra. The calculated free-energy of activation (ΔG≠) for prototropic tautomerism is about 68 ± 2 kJ mol-1.

Comment on "Applications of homogenous balanced principle on investigating exact solutions to a series of time fractional nonlinear PDEs", [Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266

NASA Astrophysics Data System (ADS)

Li, Xiangzheng

2018-06-01

A counterexample is given to show that the product rule of the Caputo fractional derivatives does not hold except on a special point. The function-expansion method of separation variable proposed by Rui[Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266] based on the product rule must be modified.

Application of Earth Sciences Products for use in Next Generation Numerical Aerosol Prediction Models

DTIC Science & Technology

2008-09-30

retrievals, Geophysical Research Abstracts, Vol. 10, EGU2008-A-11193, 2008, SRef-ID: 1607-7962/gra/EGU2008-A­ 11193, EGU General Assembly 2008. Liu, M...Application of Earth Sciences Products for use in Next Generation Numerical Aerosol...can be generated and predicted. Through this system, we will be able to advance a number of US Navy Applied Science needs in the areas of improved

Medicinal plant activity on Helicobacter pylori related diseases

PubMed Central

Wang, Yuan-Chuen

2014-01-01

More than 50% of the world population is infected with Helicobacter pylori (H. pylori). The bacterium highly links to peptic ulcer diseases and duodenal ulcer, which was classified as a group I carcinogen in 1994 by the WHO. The pathogenesis of H. pylori is contributed by its virulence factors including urease, flagella, vacuolating cytotoxin A (VacA), cytotoxin-associated gene antigen (Cag A), and others. Of those virulence factors, VacA and CagA play the key roles. Infection with H. pylori vacA-positive strains can lead to vacuolation and apoptosis, whereas infection with cagA-positive strains might result in severe gastric inflammation and gastric cancer. Numerous medicinal plants have been reported for their anti-H. pylori activity, and the relevant active compounds including polyphenols, flavonoids, quinones, coumarins, terpenoids, and alkaloids have been studied. The anti-H. pylori action mechanisms, including inhibition of enzymatic (urease, DNA gyrase, dihydrofolate reductase, N-acetyltransferase, and myeloperoxidase) and adhesive activities, high redox potential, and hydrophilic/hydrophobic natures of compounds, have also been discussed in detail. H. pylori-induced gastric inflammation may progress to superficial gastritis, atrophic gastritis, and finally gastric cancer. Many natural products have anti-H. pylori-induced inflammation activity and the relevant mechanisms include suppression of nuclear factor-κB and mitogen-activated protein kinase pathway activation and inhibition of oxidative stress. Anti-H. pylori induced gastric inflammatory effects of plant products, including quercetin, apigenin, carotenoids-rich algae, tea product, garlic extract, apple peel polyphenol, and finger-root extract, have been documented. In conclusion, many medicinal plant products possess anti-H. pylori activity as well as an anti-H. pylori-induced gastric inflammatory effect. Those plant products have showed great potential as pharmaceutical candidates for H. pylori eradication and H. pylori induced related gastric disease prevention. PMID:25132753

Medicinal plant activity on Helicobacter pylori related diseases.

PubMed

Wang, Yuan-Chuen

2014-08-14

More than 50% of the world population is infected with Helicobacter pylori (H. pylori). The bacterium highly links to peptic ulcer diseases and duodenal ulcer, which was classified as a group I carcinogen in 1994 by the WHO. The pathogenesis of H. pylori is contributed by its virulence factors including urease, flagella, vacuolating cytotoxin A (VacA), cytotoxin-associated gene antigen (Cag A), and others. Of those virulence factors, VacA and CagA play the key roles. Infection with H. pylori vacA-positive strains can lead to vacuolation and apoptosis, whereas infection with cagA-positive strains might result in severe gastric inflammation and gastric cancer. Numerous medicinal plants have been reported for their anti-H. pylori activity, and the relevant active compounds including polyphenols, flavonoids, quinones, coumarins, terpenoids, and alkaloids have been studied. The anti-H. pylori action mechanisms, including inhibition of enzymatic (urease, DNA gyrase, dihydrofolate reductase, N-acetyltransferase, and myeloperoxidase) and adhesive activities, high redox potential, and hydrophilic/hydrophobic natures of compounds, have also been discussed in detail. H. pylori-induced gastric inflammation may progress to superficial gastritis, atrophic gastritis, and finally gastric cancer. Many natural products have anti-H. pylori-induced inflammation activity and the relevant mechanisms include suppression of nuclear factor-κB and mitogen-activated protein kinase pathway activation and inhibition of oxidative stress. Anti-H. pylori induced gastric inflammatory effects of plant products, including quercetin, apigenin, carotenoids-rich algae, tea product, garlic extract, apple peel polyphenol, and finger-root extract, have been documented. In conclusion, many medicinal plant products possess anti-H. pylori activity as well as an anti-H. pylori-induced gastric inflammatory effect. Those plant products have showed great potential as pharmaceutical candidates for H. pylori eradication and H. pylori induced related gastric disease prevention.

Stable carbon isotope signals in particulate organic and inorganic carbon of coccolithophores - A numerical model study for Emiliania huxleyi.

PubMed

Holtz, Lena-Maria; Wolf-Gladrow, Dieter; Thoms, Silke

2017-05-07

A recent numerical cell model, which explains observed light and carbonate system effects on particulate organic and inorganic carbon (POC and PIC) production rates under the assumption of internal pH homeostasis, is extended for stable carbon isotopes ( 12 C, 13 C). Aim of the present study is to mechanistically understand the stable carbon isotopic fractionation signal (ε) in POC and PIC and furthermore the vital effect(s) included in measured ε PIC values. The virtual cell is divided into four compartments, for each of which the 12 C as well as the 13 C carbonate system kinetics are implemented. The compartments are connected to each other via trans-membrane fluxes. In contrast to existing carbon fractionation models, the presented model calculates the disequilibrium state for both carbonate systems and for each compartment. It furthermore calculates POC and PIC production rates as well as ε POC and ε PIC as a function of given light conditions and the compositions of the external carbonate system. Measured POC and PIC production rates as well as ε PIC values are reproduced well by the model (comparison with literature data). The observed light effect on ε POC (increase of ε POC with increasing light intensities), however, is not reproduced by the basic model set-up, which is solely based on RubisCO fractionation. When extending the latter set-up by assuming that biological fractionation includes further carbon fractionation steps besides the one of RubisCO, the observed light effect on ε POC is also reproduced. By means of the extended model version, four different vital effects that superimpose each other in a real cell can be detected. Finally, we discuss potential limitations of the ε PIC proxy. Copyright © 2017 Elsevier Ltd. All rights reserved.

Extrusion Processing of Raw Food Materials and by-products: A Review.

PubMed

Offiah, Vivian; Kontogiorgos, Vassilis; Falade, Kolawole O

2018-05-22

Extrusion technology has rapidly transformed the food industry with its numerous advantages over other processing methods. It offers a platform for processing different products from various food groups by modifying minor or major ingredients and processing conditions. Although cereals occupy a large portion of the extruded foods market, several other types of raw materials have been used. Extrusion processing of various food groups, including cereals and pseudo cereals, roots and tubers, pulses and oilseeds, fruits and vegetables, and animal products, as well as structural and nutritional changes in these food matrices are reviewed. Value addition by extrusion to food processing wastes and by-products from fruits and vegetables, dairy, meat and seafood, cereals and residues from starch, syrup and alcohol production, and oilseed processing are also discussed. Extrusion presents an economical technology for incorporating food processing residues and by-products back into the food stream. In contemporary scenarios, rising demand for extruded products with functional ingredients, attributed to evolving lifestyles and preferences, have led to innovations in the form, texture, color and content of extruded products. Information presented in this review would be of importance to processors and researchers as they seek to enhance nutritional quality and delivery of extruded products.

Consequences of electroplated targets on radiopharmaceutical preparations

NASA Astrophysics Data System (ADS)

Finn, R. D.; Tirelli, S.; Sheh, Y.; Knott, A.; Gelbard, A. S.; Larson, S. M.; Dahl, J. R.

1991-05-01

The staff of the cyclotron facility at Memorial Sloan-Kettering Cancer Center is involved in a comprehensive radionuclide preparation program which culminates with the formulation of numerous requested short-lived, positron-emitting radiopharmaceutical agents for clinical investigation. Both the produced radionuclide as well as the final radiolabeled compound are subjected to stringent quality control standards including assays for radiochemical and chemical purity. The subtle chemical consequences resulting from the irradiation of a nickel-plated target for 13N production serve to emphasize some of these potential technical difficulties.

Noise and Dissipation on Coadjoint Orbits

NASA Astrophysics Data System (ADS)

Arnaudon, Alexis; De Castro, Alex L.; Holm, Darryl D.

2018-02-01

We derive and study stochastic dissipative dynamics on coadjoint orbits by incorporating noise and dissipation into mechanical systems arising from the theory of reduction by symmetry, including a semidirect product extension. Random attractors are found for this general class of systems when the Lie algebra is semi-simple, provided the top Lyapunov exponent is positive. We study in details two canonical examples, the free rigid body and the heavy top, whose stochastic integrable reductions are found and numerical simulations of their random attractors are shown.

Positioning your business in the marketplace.

PubMed

Lachman, V D

1996-01-01

Marketing the quality, cost-effective service delivered by advanced practice nurses (APNs) requires savvy in marketing principles. The basic principles of market segmentation: target (niche) marketing; and the four Ps of marketing mix--product, price, promotion, and place. The marketing process is presented along with examples. APNs' ability to successfully market their skills requires that they "position" themselves in the prospective buyer's mind. After a brief description of the customer's mind-set, the focus shifts specifically to promotion--marketing in action. Numerous no-cost/low-cost ideas are included.

Cognitive culture: theoretical and empirical insights into social learning strategies.

PubMed

Rendell, Luke; Fogarty, Laurel; Hoppitt, William J E; Morgan, Thomas J H; Webster, Mike M; Laland, Kevin N

2011-02-01

Research into social learning (learning from others) has expanded significantly in recent years, not least because of productive interactions between theoretical and empirical approaches. This has been coupled with a new emphasis on learning strategies, which places social learning within a cognitive decision-making framework. Understanding when, how and why individuals learn from others is a significant challenge, but one that is critical to numerous fields in multiple academic disciplines, including the study of social cognition. Copyright © 2010 Elsevier Ltd. All rights reserved.

A Validation of the Proposed Royal Australian Navy Standard Work Week and Naval Management Diary Using a Simulated Crew of an Armidale Class Patrol Boat

DTIC Science & Technology

2015-12-01

Reduced mental capacity, poor decision making, emotional outbursts or withdrawals, and reduced alertness are among the side effects that have been...Guide.” The guide defined fatigue as “the product of intense and prolonged emotional strain, poor and inadequate diet, strenuous physical exertion...scheduling bodily functions and periods of sleepiness and wakefulness. Circadian rhythms control numerous factors in the human body including body

Audit of manufactured products: use of allergen advisory labels and identification of labeling ambiguities.

PubMed

Pieretti, Mariah M; Chung, Danna; Pacenza, Robert; Slotkin, Todd; Sicherer, Scott H

2009-08-01

The Food Allergy Labeling and Consumer Protection Act became effective January 1, 2006, and mandates disclosure of the 8 major allergens in plain English and as a source of ingredients in the ingredient statement. It does not regulate advisory labels. We sought to determine the frequency and language used in voluntary advisory labels among commercially available products and to identify labeling ambiguities affecting consumers with allergy. Trained surveyors performed a supermarket survey of 20,241 unique manufactured food products (from an original assessment of 49,604 products) for use of advisory labels. A second detailed survey of 744 unique products evaluated additional labeling practices. Overall, 17% of 20,241 products surveyed contain advisory labels. Chocolate candy, cookies, and baking mixes were the 3 categories of 24 with the greatest frequency (> or = 40%). Categorically, advisory warnings included "may contain" (38%), "shared equipment" (33%), and "within plant" (29%). The subsurvey disclosed 25 different types of advisory terminology. Nonspecific terms, such as "natural flavors" and "spices," were found on 65% of products and were not linked to a specific ingredient for 83% of them. Additional ambiguities included unclear sources of soy (lecithin vs protein), nondisclosure of sources of gelatin and lecithin, and simultaneous disclosure of "contains" and "may contain" for the same allergen, among others. Numerous products have advisory labeling and ambiguities that present challenges to consumers with food allergy. Additional allergen labeling regulation could improve safety and quality of life for individuals with food allergy.

Genomic evolution in domestic cattle: ancestral haplotypes and healthy beef.

PubMed

Williamson, Joseph F; Steele, Edward J; Lester, Susan; Kalai, Oscar; Millman, John A; Wolrige, Lindsay; Bayard, Dominic; McLure, Craig; Dawkins, Roger L

2011-05-01

We have identified numerous Ancestral Haplotypes encoding a 14-Mb region of Bota C19. Three are frequent in Simmental, Angus and Wagyu and have been conserved since common progenitor populations. Others are more relevant to the differences between these 3 breeds including fat content and distribution in muscle. SREBF1 and Growth Hormone, which have been implicated in the production of healthy beef, are included within these haplotypes. However, we conclude that alleles at these 2 loci are less important than other sequences within the haplotypes. Identification of breeds and hybrids is improved by using haplotypes rather than individual alleles. Copyright © 2010 Elsevier Inc. All rights reserved.

Numerical modeling of laser assisted tape winding process

NASA Astrophysics Data System (ADS)

Zaami, Amin; Baran, Ismet; Akkerman, Remko

2017-10-01

Laser assisted tape winding (LATW) has become more and more popular way of producing new thermoplastic products such as ultra-deep sea water riser, gas tanks, structural parts for aerospace applications. Predicting the temperature in LATW has been a source of great interest since the temperature at nip-point plays a key role for mechanical interface performance. Modeling the LATW process includes several challenges such as the interaction of optics and heat transfer. In the current study, numerical modeling of the optical behavior of laser radiation on circular surfaces is investigated based on a ray tracing and non-specular reflection model. The non-specular reflection is implemented considering the anisotropic reflective behavior of the fiber-reinforced thermoplastic tape using a bidirectional reflectance distribution function (BRDF). The proposed model in the present paper includes a three-dimensional circular geometry, in which the effects of reflection from different ranges of the circular surface as well as effect of process parameters on temperature distribution are studied. The heat transfer model is constructed using a fully implicit method. The effect of process parameters on the nip-point temperature is examined. Furthermore, several laser distributions including Gaussian and linear are examined which has not been considered in literature up to now.

Numerical simulation of wave-current interaction under strong wind conditions

NASA Astrophysics Data System (ADS)

Larrañaga, Marco; Osuna, Pedro; Ocampo-Torres, Francisco Javier

2017-04-01

Although ocean surface waves are known to play an important role in the momentum and other scalar transfer between the atmosphere and the ocean, most operational numerical models do not explicitly include the terms of wave-current interaction. In this work, a numerical analysis about the relative importance of the processes associated with the wave-current interaction under strong off-shore wind conditions in Gulf of Tehuantepec (the southern Mexican Pacific) was carried out. The numerical system includes the spectral wave model WAM and the 3D hydrodynamic model POLCOMS, with the vertical turbulent mixing parametrized by the kappa-epsilon closure model. The coupling methodology is based on the vortex-force formalism. The hydrodynamic model was forced at the open boundaries using the HYCOM database and the wave model was forced at the open boundaries by remote waves from the southern Pacific. The atmospheric forcing for both models was provided by a local implementation of the WRF model, forced at the open boundaries using the CFSR database. The preliminary analysis of the model results indicates an effect of currents on the propagation of the swell throughout the study area. The Stokes-Coriolis term have an impact on the transient Ekman transport by modifying the Ekman spiral, while the Stokes drift has an effect on the momentum advection and the production of TKE, where the later induces a deepening of the mixing layer. This study is carried out in the framework of the project CONACYT CB-2015-01 255377 and RugDiSMar Project (CONACYT 155793).

Numerical simulation of transport processes in injection mold-filling during production of a cylindrical object under isothermal and non-isothermal conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, A.; Ghoshdastidar, P.S.

1999-07-01

In this paper, numerical simulation of injection mold-filling during the production of a cylindrical object under isothermal and non-isothermal conditions is presented. The material of the object is low density polyethylene (LDPE) following power-law viscosity model for non-zero shear rate zone. However, where shear rate becomes zero, zero-shear viscosity value has been used. Three cases have been considered, namely (1) Isothermal filling at constant injection pressure, (2) Isothermal filling at constant flow rate, and (3) Non-isothermal filling at constant flow rate. For the case-(3), the viscosity of LDPE is also a function of temperature. The material of the mold ismore » steel. For the non-isothermal filling, the concept of melt-mold thermal contact resistance coefficient has been incorporated in the model. The length and diameter of the body in all three cases have been taken as 0.254 m and 0.00508 m respectively. The finite-difference method has been used to solve the governing differential equations for the processes. The results show excellent agreement with the corresponding equations for the processes. The results show excellent agreement with the corresponding analytical solutions for the first two cases showing the correctness of the numerical method. The simulation results for non-isothermal filling show physically realistic trends and lend insight into various important aspects of mold-filling including frozen skin layer.« less

The effect of mineral dust and soot aerosols on ice microphysics near the foothills of the Himalayas: A numerical investigation

NASA Astrophysics Data System (ADS)

Hazra, Anupam; Padmakumari, B.; Maheskumar, R. S.; Chen, Jen-Ping

2016-05-01

This study investigates the influence of different ice nuclei (IN) species and their number concentrations on cloud ice production. The numerical simulation with different species of ice nuclei is investigated using an explicit bulk-water microphysical scheme in a Mesoscale Meteorological Model version 5 (MM5). The species dependent ice nucleation parameterization that is based on the classical nucleation theory has been implemented into the model. The IN species considered include dust and soot with two different concentrations (Low and High). The simulated cloud microphysical properties like droplet number concentration and droplet effective radii as well as macro-properties (equivalent potential temperature and relative humidity) are comparable with aircraft observations. When higher dust IN concentrations are considered, the simulation results showed good agreement with the cloud ice and cloud water mixing ratio from aircraft measurements during Cloud Aerosol Interactions and Precipitation Enhancement Experiment (CAIPEEX) and Modern Era Retrospective Analysis for Research and Applications (MERRA) reanalysis. Relative importance of IN species is shown as compared to the homogeneous freezing nucleation process. The tendency of cloud ice production rates is also analyzed and found that dust IN is more efficient in producing cloud ice when compared to soot IN. The dust IN with high concentration can produce more surface precipitation than soot IN at the same concentration. This study highlights the need to improve the ice nucleation parameterization in numerical models.

Numerically simulated two-dimensional auroral double layers

NASA Technical Reports Server (NTRS)

Borovsky, J. E.; Joyce, G.

1983-01-01

A magnetized 2 1/2-dimensional particle-in-cell system which is periodic in one direction and bounded by reservoirs of Maxwellian plasma in the other is used to numerically simulate electrostatic plasma double layers. For the cases of both oblique and two-dimensional double layers, the present results indicate periodic instability, Debye length rather than gyroradii scaling, and low frequency electrostatic turbulence together with electron beam-excited electrostatatic electron-cyclotron waves. Estimates are given for the thickness of auroral doule layers, as well as the separations within multiple auroral arcs. Attention is given to the temporal modulation of accelerated beams, and the possibilities for ion precipitation and ion conic production by the double layer are hypothesized. Simulations which include the atmospheric backscattering of electrons imply the action of an ionospheric sheath which accelerates ionospheric ions upward.

Simulation analysis of a novel high efficiency silicon solar cell

NASA Technical Reports Server (NTRS)

Mokashi, Anant R.; Daud, T.; Kachare, A. H.

1985-01-01

It is recognized that crystalline silicon photovoltaic module efficiency of 15 percent or more is required for cost-effective photovoltaic energy utilization. This level of module efficiency requires large-area encapsulated production cell efficiencies in the range of 18 to 20 percent. Though the theoretical maximum of silicon solar cell efficiency for an idealized case is estimated to be around 30 percent, practical performance of cells to-date are considerably below this limit. This is understood to be largely a consequence of minority carrier losses in the bulk as well as at all surfaces including those under the metal contacts. In this paper a novel device design with special features to reduce bulk and surface recombination losses is evaluated using numerical analysis technique. Details of the numerical model, cell design, and analysis results are presented.

Comparing the Impact of Prescription Omega-3 Fatty Acid Products on Low-Density Lipoprotein Cholesterol.

PubMed

Sharp, Randall P; Gales, Barry J; Sirajuddin, Riaz

2018-04-01

Elevated levels of triglycerides are associated with pancreatitis and an increased risk of coronary heart disease. Numerous pharmacologic therapies are available to treat hypertriglyceridemia, including prescription omega-3 fatty acids, which reduce triglyceride levels by 20-50%. Available data indicate the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be beneficial for secondary prevention of coronary heart disease. Products containing DHA may increase low-density lipoprotein cholesterol (LDL-C) and, subsequently, coronary heart disease risk. We reviewed prescription omega-3 fatty acid products, of which two-omega-3 acid ethyl esters (OM3EE) and omega-3 carboxylic acid (OM3CA)-contain both DHA and EPA, whereas the other-icosapent ethyl (IPE)-contains EPA only. We identified three retrospective chart reviews and three case reports comparing IPE with OM3EE, whereas two studies compared IPE with placebo. We also reviewed the major studies of OM3EE versus placebo used to gain US FDA approval. LDL-C levels decreased or did not increase significantly in all available studies and case reports in patients receiving the IPE product, with the best data supporting a dose of 4 g per day. The majority of studies only included patients taking IPE concomitantly with statins, but limited data from one study using IPE monotherapy showed a small reduction in LDL-C. Many questions remain regarding IPE, including whether the product reduces cardiovascular events and mortality.

Utilizing Radiofrequency Identification Technology to Improve Safety and Management of Blood Bank Supply Chains.

PubMed

Coustasse, Alberto; Meadows, Pamela; Hall, Robert S; Hibner, Travis; Deslich, Stacie

2015-11-01

The importance of efficiency in the supply chain of perishable products, such as the blood products used in transfusion services, cannot be overstated. Many problems can occur, such as the outdating of products, inventory management issues, patient misidentification, and mistransfusion. The purpose of this article was to identify the benefits and barriers associated with radiofrequency identification (RFID) usage in improving the blood bank supply chain. The methodology for this study was a qualitative literature review following a systematic approach. The review was limited to sources published from 2000 to 2014 in the English language. Sixty-five sources were found, and 56 were used in this research study. According to the finding of the present study, there are numerous benefits and barriers to RFID utilization in blood bank supply chains. RFID technology offers several benefits with regard to blood bank product management, including decreased transfusion errors, reduction of product loss, and more efficient inventory management. Barriers to RFID implementation include the cost associated with system implementation and patient privacy issues. Implementation of an RFID system can be a significant investment. However, when observing the positive impact that such systems may have on transfusion safety and inventory management, the cost associated with RFID systems can easily be justified. RFID in blood bank inventory management is vital to ensuring efficient product inventory management and positive patient outcomes.

Pathways and supply of dissolved iron in the Amundsen Sea (Antarctica)

NASA Astrophysics Data System (ADS)

St-Laurent, P.; Yager, P. L.; Sherrell, R. M.; Stammerjohn, S. E.; Dinniman, M. S.

2017-09-01

Numerous coastal polynyas fringe the Antarctic continent and strongly influence the productivity of Antarctic shelf systems. Of the 46 Antarctic coastal polynyas documented in a recent study, the Amundsen Sea Polynya (ASP) stands out as having the highest net primary production per unit area. Incubation experiments suggest that this productivity is partly controlled by the availability of dissolved iron (dFe). As a first step toward understanding the iron supply of the ASP, we introduce four plausible sources of dFe and simulate their steady spatial distribution using conservative numerical tracers. The modeled distributions replicate important features from observations including dFe maxima at the bottom of deep troughs and enhanced concentrations near the ice shelf fronts. A perturbation experiment with an idealized drawdown mimicking summertime biological uptake and subsequent resupply suggests that glacial meltwater and sediment-derived dFe are the main contributors to the prebloom dFe inventory in the top 100 m of the ASP. The sediment-derived dFe depends strongly on the buoyancy-driven overturning circulation associated with the melting ice shelves (the "meltwater pump") to add dFe to the upper 300 m of the water column. The results support the view that ice shelf melting plays an important direct and indirect role in the dFe supply and delivery to polynyas such as the ASP.

How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies

NASA Astrophysics Data System (ADS)

Shen, Liang; Liu, Cui-Cui; An, Chun-Yan; Ji, Hong-Fang

2016-02-01

Curcumin is a natural product with multiple biological activities and numerous potential therapeutic applications. However, its poor systemic bioavailability fails to explain the potent pharmacological effects and hinders its clinical application. Using experimental and theoretical approaches, we compared curcumin and its degradation products for its biological activities against Alzheimer’s disease (AD), including the superoxide anion radical (O2.-)-scavenging activity, Aβ fibrils (fAβ) formation-inhibiting activity, and enzymatic inhibition activity. We showed that compared to the parent compound curcumin, the degradation products mixture possessed higher O2.--scavenging activity and stronger inhibition against fAβ formation. The docking simulations revealed that the bioactive degradation products should make important contribution to the experimentally observed enzymatic inhibition activities of curcumin. Given that curcumin is readily degraded under physiological condition, our findings strongly suggested that the degradation products should make important contribution to the diverse biological activities of curcumin. Our novel findings not only provide novel insights into the complex pharmacology of curcumin due to its poor bioavailability, but also open new avenues for developing therapeutic applications of this natural product.

Kinetic model development for biogas production from cattle dung

NASA Astrophysics Data System (ADS)

Ghatak, Manjula Das; Mahanta, P.

2017-07-01

Biogas is a mixture of methane, carbon dioxide and traces of numerous trace of elements. It is produced by anaerobic digestion of organic matters including cattle dung which depend upon various factors affecting the population and activity of microorganisms producing biogas. Among the various factors temperature is one of them which play a significant role in biogas production from cattle dung. Biogas production from cattle dung was studied at temperatures 35°C to 55°C at a step of 5°C to study the effect of temperature on biogas production from cattle dung. In this work a mathematical model is developed for evaluating the effect of temperature on the rate of biogas production from cattle dung. The new mathematical model is derived by adding the effect of temperature on the modified Gompertz model. The new model is found to be suitable for predicting the biogas production from cattle dung in the temperature range 35°C to 55°C. The results from the new model are found to be highly correlated to the experimental data of present study.

Hepatic Transcriptome Responses in Mice (Mus musculus) Exposed to the Nafion Membrane and Its Combustion Products

PubMed Central

Feng, Mingbao; Qu, Ruijuan; Habteselassie, Mussie; Wu, Jun; Yang, Shaogui; Sun, Ping; Huang, Qingguo; Wang, Zunyao

2015-01-01

Nafion 117 membrane (N117), an important polymer electrolyte membrane (PEM), has been widely used for numerous chemical technologies. Despite its increasing production and use, the toxicity data for N117 and its combustion products remain lacking. Toxicity studies are necessary to avoid problems related to waste disposal in landfills and incineration that may arise. In this study, we investigated the histopathological alterations, oxidative stress biomarker responses, and transcriptome profiles in the liver of male mice exposed to N117 and its combustion products for 24 days. An ion-chromatography system and liquid chromatography system coupled to a hybrid quadrupole time-of-flight mass spectrometry were used to analyze the chemical compositions of these combustion products. The transcriptomics analysis identified several significantly altered molecular pathways, including the metabolism of xenobiotics, carbohydrates and lipids; signal transduction; cellular processes; immune system; and signaling molecules and interaction. These studies provide preliminary data for the potential toxicity of N117 and its combustion products on living organisms and may fill the information gaps in the toxicity databases for the currently used PEMs. PMID:26057616

16 CFR 500.7 - Net quantity of contents, method of expression.

Code of Federal Regulations, 2014 CFR

2014-01-01

... expression. The net quantity of contents shall be expressed in terms of weight or mass, measure, numerical count, or a combination of numerical count and weight or mass, size, or measure so as to give accurate... measure, numerical count, and/or size, or (as in the case of lawn and plant care products) by cubic...

16 CFR 500.7 - Net quantity of contents, method of expression.

Code of Federal Regulations, 2012 CFR

2012-01-01

... expression. The net quantity of contents shall be expressed in terms of weight or mass, measure, numerical count, or a combination of numerical count and weight or mass, size, or measure so as to give accurate... measure, numerical count, and/or size, or (as in the case of lawn and plant care products) by cubic...

16 CFR 500.7 - Net quantity of contents, method of expression.

Code of Federal Regulations, 2013 CFR

2013-01-01

... expression. The net quantity of contents shall be expressed in terms of weight or mass, measure, numerical count, or a combination of numerical count and weight or mass, size, or measure so as to give accurate... measure, numerical count, and/or size, or (as in the case of lawn and plant care products) by cubic...

16 CFR 500.7 - Net quantity of contents, method of expression.

Code of Federal Regulations, 2011 CFR

2011-01-01

... expression. The net quantity of contents shall be expressed in terms of weight or mass, measure, numerical count, or a combination of numerical count and weight or mass, size, or measure so as to give accurate... measure, numerical count, and/or size, or (as in the case of lawn and plant care products) by cubic...

A numerical algorithm with preference statements to evaluate the performance of scientists.

PubMed

Ricker, Martin

Academic evaluation committees have been increasingly receptive for using the number of published indexed articles, as well as citations, to evaluate the performance of scientists. It is, however, impossible to develop a stand-alone, objective numerical algorithm for the evaluation of academic activities, because any evaluation necessarily includes subjective preference statements. In a market, the market prices represent preference statements, but scientists work largely in a non-market context. I propose a numerical algorithm that serves to determine the distribution of reward money in Mexico's evaluation system, which uses relative prices of scientific goods and services as input. The relative prices would be determined by an evaluation committee. In this way, large evaluation systems (like Mexico's Sistema Nacional de Investigadores ) could work semi-automatically, but not arbitrarily or superficially, to determine quantitatively the academic performance of scientists every few years. Data of 73 scientists from the Biology Institute of Mexico's National University are analyzed, and it is shown that the reward assignation and academic priorities depend heavily on those preferences. A maximum number of products or activities to be evaluated is recommended, to encourage quality over quantity.

Fully coupled methods for multiphase morphodynamics

NASA Astrophysics Data System (ADS)

Michoski, C.; Dawson, C.; Mirabito, C.; Kubatko, E. J.; Wirasaet, D.; Westerink, J. J.

2013-09-01

We present numerical methods for a system of equations consisting of the two dimensional Saint-Venant shallow water equations (SWEs) fully coupled to a completely generalized Exner formulation of hydrodynamically driven sediment discharge. This formulation is implemented by way of a discontinuous Galerkin (DG) finite element method, using a Roe Flux for the advective components and the unified form for the dissipative components. We implement a number of Runge-Kutta time integrators, including a family of strong stability preserving (SSP) schemes, and Runge-Kutta Chebyshev (RKC) methods. A brief discussion is provided regarding implementational details for generalizable computer algebra tokenization using arbitrary algebraic fluxes. We then run numerical experiments to show standard convergence rates, and discuss important mathematical and numerical nuances that arise due to prominent features in the coupled system, such as the emergence of nondifferentiable and sharp zero crossing functions, radii of convergence in manufactured solutions, and nonconservative product (NCP) formalisms. Finally we present a challenging application model concerning hydrothermal venting across metalliferous muds in the presence of chemical reactions occurring in low pH environments.

Production of τ τ jj final states at the LHC and the TauSpinner algorithm: the spin-2 case

NASA Astrophysics Data System (ADS)

Bahmani, M.; Kalinowski, J.; Kotlarski, W.; Richter-Wąs, E.; Wąs, Z.

2018-01-01

The TauSpinner algorithm is a tool that allows one to modify the physics model of the Monte Carlo generated samples due to the changed assumptions of event production dynamics, but without the need of re-generating events. With the help of weights τ -lepton production or decay processes can be modified accordingly to a new physics model. In a recent paper a new version TauSpinner ver.2.0.0 has been presented which includes a provision for introducing non-standard states and couplings and study their effects in the vector-boson-fusion processes by exploiting the spin correlations of τ -lepton pair decay products in processes where final states include also two hard jets. In the present paper we document how this can be achieved taking as an example the non-standard spin-2 state that couples to Standard Model particles and tree-level matrix elements with complete helicity information included for the parton-parton scattering amplitudes into a τ -lepton pair and two outgoing partons. This implementation is prepared as the external (user-provided) routine for the TauSpinner algorithm. It exploits amplitudes generated by MadGraph5 and adapted to the TauSpinner algorithm format. Consistency tests of the implemented matrix elements, re-weighting algorithm and numerical results for observables sensitive to τ polarisation are presented.

Digital high speed programmable convolver

NASA Astrophysics Data System (ADS)

Rearick, T. C.

1984-12-01

A circuit module for rapidly calculating a discrete numerical convolution is described. A convolution such as finding the sum of the products of a 16 bit constant and a 16 bit variable is performed by a module which is programmable so that the constant may be changed for a new problem. In addition, the module may be programmed to find the sum of the products of 4 and 8 bit constants and variables. RAM (Random Access Memories) are loaded with partial products of the selected constant and all possible variables. Then, when the actual variable is loaded, it acts as an address to find the correct partial product in the particular RAM. The partial products from all of the RAMs are shifted to the appropriate numerical power position (if necessary) and then added in adder elements.

Health Safety of Soft Drinks: Contents, Containers, and Microorganisms

PubMed Central

2015-01-01

Soft drinks consumption is still a controversial issue for public health and public policy. Over the years, numerous studies have been conducted into the possible links between soft drink intake and medical problems, the results of which, however, remain highly contested. Nevertheless, as a result, increasing emphasis is being placed on the health properties of soft drinks, by both the industry and the consumers, for example, in the expanding area of functional drinks. Extensive legislation has been put in place to ensure that soft drinks manufacturers conform to established national and international standards. Consumers trust that the soft drinks they buy are safe and their quality is guaranteed. They also expect to be provided with information that can help them to make informed decisions about the purchase of products and that the information on product labels is not false or misleading. This paper provides a broad overview of available scientific knowledge and cites numerous studies on various aspects of soft drinks and their implications for health safety. Particular attention is given to ingredients, including artificial flavorings, colorings, and preservatives and to the lesser known risks of microbiological and chemical contamination during processing and storage. PMID:25695045

Residential staff responses to adolescent self-harm: The helpful and unhelpful.

PubMed

Johnson, Dan R; Ferguson, Kirstin; Copley, Jennifer

2017-07-01

Adolescent self-harm is prevalent in residential and secure care and is the cause of distress to those harming themselves, to the staff caring for them and for other young people living with them. This article sought service user views on what staff supports were effective and what were counter-productive in order to improve the care offered to young people. Seven young people living in residential or secure care were interviewed. Thematic analysis was used to elicit key themes. Global themes of safety and care were elicited. The young people understood and accepted that the role of staff was to provide these. Within these themes, they noted numerous responses that had both helpful and unhelpful effects, including increased observation, removal of means and extra collaborative support. Service users made numerous recommendations to increase the helpful effects of staff support. Young people provided informed and helpful guidance on how best to care for them. Their views can help mental health professionals and care staff increase their helpful responses making them more effective and less counter-productive. This study is a rare representation of the views of young people in residential and secure care and how to respond to their self-harm behaviour.

Health safety of soft drinks: contents, containers, and microorganisms.

PubMed

Kregiel, Dorota

2015-01-01

Soft drinks consumption is still a controversial issue for public health and public policy. Over the years, numerous studies have been conducted into the possible links between soft drink intake and medical problems, the results of which, however, remain highly contested. Nevertheless, as a result, increasing emphasis is being placed on the health properties of soft drinks, by both the industry and the consumers, for example, in the expanding area of functional drinks. Extensive legislation has been put in place to ensure that soft drinks manufacturers conform to established national and international standards. Consumers trust that the soft drinks they buy are safe and their quality is guaranteed. They also expect to be provided with information that can help them to make informed decisions about the purchase of products and that the information on product labels is not false or misleading. This paper provides a broad overview of available scientific knowledge and cites numerous studies on various aspects of soft drinks and their implications for health safety. Particular attention is given to ingredients, including artificial flavorings, colorings, and preservatives and to the lesser known risks of microbiological and chemical contamination during processing and storage.

Study the Seasonal Variability of Plankton and Forage Fish in the Gulf of Khambhat Using Npzfd Model

NASA Astrophysics Data System (ADS)

Kumar, V.; Kumar, S.

2016-02-01

Numerical modelling of marine ecology exploits several assumptions and it is indeed quite challenging to include marine ecological phenomena into a mathematical framework with too many unknown parameters. The governing ordinary differential equations represent the interaction of the biological and chemical processes in a marine environment. The key concern in the development of a numerical models are parameterizations based on output, viz., mathematical modelling of ecological system mainly depends on parameters and its variations. Almost, all constituents of each trophic level of marine food web are depended on phytoplankton, which are mostly influenced by initial slope of P-I curve and nutrient stock in the study domain. Whereas, the earlier plankton dynamic models rarely include a compartment of small fish and as an agent in zooplankton mortality, which is most important for the modelling of higher trophic level of marine species. A compartment of forage fish in the modelling of plankton dynamics has been given more realistic mortality rates of plankton, viz., they feed upon phytoplankton and zooplankton. The inclusion of an additional compartment increases complexity of earlier plankton dynamics model as it introduces additional unknown parameters, which has been specified for performing the numerical simulations.As a case study we applied our analysis to explain the aquatic ecology of Gulf of Khambhat (19o 48' N - 22o20' N, 65o E - 72o40' E), west coast of India, which has rich bio-diversity and a high productive area in the form of plankton and forage fish. It has elevated turbidity and varying geography location, viz., one of the regions among world's ocean with high biological productivity.The model presented in this study is able to bring out the essential features of the observed data; that includes the bimodal oscillations in the observed data, monthly mean chlorophyll-a in the SeaWiFs/MODIS Aqua data and in-situ data of plankton. The additional compartment of forage fish and detritus in NPZFD model represents a major structural difference from the earlier NPZ model.

Numerical evidences for the angular momentum-mass inequality for multiple axially symmetric black holes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dain, Sergio; Ortiz, Omar E.; Facultad de Matematica, Astronomia y Fisica, Universidad Nacional de Cordoba, Ciudad Universitaria

2009-07-15

We present numerical evidences for the validity of the inequality between the total mass and the total angular momentum for multiple axially symmetric (nonstationary) black holes. We use a parabolic heat flow to solve numerically the stationary axially symmetric Einstein equations. As a by-product of our method, we also give numerical evidences that there are no regular solutions of Einstein equations that describe two extreme, axially symmetric black holes in equilibrium.

Coupling Hydraulic Fracturing Propagation and Gas Well Performance for Simulation of Production in Unconventional Shale Gas Reservoirs

NASA Astrophysics Data System (ADS)

Wang, C.; Winterfeld, P. H.; Wu, Y. S.; Wang, Y.; Chen, D.; Yin, C.; Pan, Z.

2014-12-01

Hydraulic fracturing combined with horizontal drilling has made it possible to economically produce natural gas from unconventional shale gas reservoirs. An efficient methodology for evaluating hydraulic fracturing operation parameters, such as fluid and proppant properties, injection rates, and wellhead pressure, is essential for the evaluation and efficient design of these processes. Traditional numerical evaluation and optimization approaches are usually based on simulated fracture properties such as the fracture area. In our opinion, a methodology based on simulated production data is better, because production is the goal of hydraulic fracturing and we can calibrate this approach with production data that is already known. This numerical methodology requires a fully-coupled hydraulic fracture propagation and multi-phase flow model. In this paper, we present a general fully-coupled numerical framework to simulate hydraulic fracturing and post-fracture gas well performance. This three-dimensional, multi-phase simulator focuses on: (1) fracture width increase and fracture propagation that occurs as slurry is injected into the fracture, (2) erosion caused by fracture fluids and leakoff, (3) proppant subsidence and flowback, and (4) multi-phase fluid flow through various-scaled anisotropic natural and man-made fractures. Mathematical and numerical details on how to fully couple the fracture propagation and fluid flow parts are discussed. Hydraulic fracturing and production operation parameters, and properties of the reservoir, fluids, and proppants, are taken into account. The well may be horizontal, vertical, or deviated, as well as open-hole or cemented. The simulator is verified based on benchmarks from the literature and we show its application by simulating fracture network (hydraulic and natural fractures) propagation and production data history matching of a field in China. We also conduct a series of real-data modeling studies with different combinations of hydraulic fracturing parameters and present the methodology to design these operations with feedback of simulated production data. The unified model aids in the optimization of hydraulic fracturing design, operations, and production.

Bioelectrohydrogenesis and inhibition of methanogenic activity in microbial electrolysis cells - A review.

PubMed

Karthikeyan, Rengasamy; Cheng, Ka Yu; Selvam, Ammaiyappan; Bose, Arpita; Wong, Jonathan W C

2017-11-01

Microbial electrolysis cells (MECs) are a promising technology for biological hydrogen production. Compared to abiotic water electrolysis, a much lower electrical voltage (~0.2V) is required for hydrogen production in MECs. It is also an attractive waste treatment technology as a variety of biodegradable substances can be used as the process feedstock. Underpinning this technology is a recently discovered bioelectrochemical pathway known as "bioelectrohydrogenesis". However, little is known about the mechanism of this pathway, and numerous hurdles are yet to be addressed to maximize hydrogen yield and purity. Here, we review various aspects including reactor configurations, microorganisms, substrates, electrode materials, and inhibitors of methanogenesis in order to improve hydrogen generation in MECs. Copyright © 2017 Elsevier Inc. All rights reserved.

Laboratory measurements and methane photochemistry modeling

NASA Technical Reports Server (NTRS)

Romani, P. N.

1990-01-01

Methane is photolyzed by the solar UV in the stratosphere of Saturn. Subsequent photochemistry leads to the production of acetylene (C2H2) and diacetylene (C4H2). These species are produced where it is relatively warm (T is greater than or equal to 140 K), but the tropopause temperature of Saturn (approximately 80 K) is low enough that these two species may freeze out to their respective ices. Numerical models which include both photochemistry and condensation loss make predictions about the mixing ratios of these species and haze production rates. These models are dependent upon knowing reaction pathways and their associated kinetic reaction rate constants and vapor pressures. How uncertainties in the chemistry and improvements in the vapor pressures affect model predictions for Saturn are discussed.

Novel 3D coaxial flow-focusing nozzle device for the production of monodispersed collagen microspheres.

PubMed

Jaligama, Sravani; Po-Jung Huang; Kameoka, Jun

2016-08-01

We have developed a 3D coaxial flow-focusing nozzle device for the mass production of monodispersed collagen microspheres and chemically crosslinked them using EDC (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide) and N-hydroxysuccinimide (NHS). The size of the microspheres was varied between 200 μm and 600 μm by adjusting the ratio of the flow rates of the dispersed and continuous phases. MDA231-GFP cells were attached to the surface of these particles and their viability was investigated. Because they are comprised of a natural biomaterial, these collagen microspheres will have numerous applications, including bone regeneration scaffolds for tissue engineering and analyses of cancer cell interactions in a 3D environment.

Distribution Locational Real-Time Pricing Based Smart Building Control and Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Jun; Dai, Xiaoxiao; Zhang, Yingchen

This paper proposes an real-virtual parallel computing scheme for smart building operations aiming at augmenting overall social welfare. The University of Denver's campus power grid and Ritchie fitness center is used for demonstrating the proposed approach. An artificial virtual system is built in parallel to the real physical system to evaluate the overall social cost of the building operation based on the social science based working productivity model, numerical experiment based building energy consumption model and the power system based real-time pricing mechanism. Through interactive feedback exchanged between the real and virtual system, enlarged social welfare, including monetary cost reductionmore » and energy saving, as well as working productivity improvements, can be achieved.« less

Groundwater availability study for Guam; goals, approach, products, and schedule of activities

USGS Publications Warehouse

Gingerich, Stephen B.; Jenson, John W.

2010-01-01

An expected significant population increase on Guam has raised concern about the sustainability of groundwater resources. In response, the U.S. Geological Survey (USGS), in collaboration with the University of Guam's Water and Environmental Research Institute of the Western Pacific (WERI) and with funding from the U.S. Marine Corps (USMC), is conducting a 3.5-year study to advance understanding of regional groundwater dynamics in the Northern Guam Lens Aquifer, provide a new estimate of groundwater recharge, and develop a numerical groundwater flow and transport model for northern Guam. Results of the study, including two USGS reports and a well database, will provide more reliable evaluations of the potential effects of groundwater production and help guide sustainable management of this critical resource.

[Participation, knowledge production, and evaluative research: participation by different actors in a mental health study].

PubMed

Furtado, Juarez Pereira; Campos, Rosana Onocko

2008-11-01

This article reflects on the interrelations between participation, knowledge production, and public policy evaluation in light of issues from our own experience with evaluative research on a municipal network of Psychosocial Care Centers (CAPS) in Brazil. The article discusses the coordination of the complex process and the potentials and limits of partnerships for conducting qualitative evaluative studies in mental health with participation by different social actors. The authors conclude that qualitative evaluative research aligned with the perspective of including different points of view representing various segments is the best approach for understanding the numerous spin-offs from the implementation of services linked to the Brazilian psychiatric reform movement, given the inherent specificities of the mental health field.

Recent development of recycling lead from scrap CRTs: A technological review.

PubMed

Yu-Gong; Tian, Xiang-Miao; Wu, Yu-Feng; Zhe-Tan; Lei-Lv

2016-11-01

Cathode ray tubes (CRTs) contain numerous harmful substances with different functions. Lead is found in the funnel glass of CRTs. Improperly treated toxic lead may pose significant risks to human health and the environment. This paper reviews and summarizes existing technological processes on the recycling of lead from waste CRTs, including pyrometallurgy, hydrometallurgy, and product-regeneration. The present situation, advantages, and disadvantages of these techniques are described in detail. Generally, pyrometallurgy shows better practicability in recovery lead from waste CRT than hydrometallurgy and hydrometallurgy, in view of environmental impact, energy-consumption, product formats and safety and maturity of technology. Moreover, the gaps in the existing technologies were identified and recommendations for future research were provided. Copyright © 2015 Elsevier Ltd. All rights reserved.

Gastric and duodenal antiulcer activity of alkaloids: a review.

PubMed

de Sousa Falcão, Heloina; Leite, Jacqueline Alves; Barbosa-Filho, José Maria; de Athayde-Filho, Petrônio Filgueiras; de Oliveira Chaves, Maria Célia; Moura, Marcelo Dantas; Ferreira, Anderson Luiz; de Almeida, Ana Beatriz Albino; Souza-Brito, Alba Regina Monteiro; de Fátima Formiga Melo Diniz, Margareth; Batista, Leônia Maria

2008-12-17

Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.

A Regular Production-Remanufacturing Inventory Model for a Two-Echelon System with Price-dependent Return Rate and Environmental Effects Investigation

NASA Astrophysics Data System (ADS)

Dwicahyani, A. R.; Jauhari, W. A.; Jonrinaldi

2017-06-01

Product take-back recovery has currently became a promising effort for companies in order to create a sustainable supply chain. In addition, some restrictions including government regulations, social-ethical responsibilities, and up to economic factors have contributed to the reasons for the importance of product take-back recovery. This study aims to develop an inventory model in a system of reverse logistic management consisting of a manufacturer and a collector. Recycle dealer collects used products from the market and ships it to manufacturer. Manufacturer then recovers the used products and sell it eventually to the market. Some recovered products that can not be recovered as good as new one will be sold to the secondary market. In this study, we investigate the effects of environmental factors including GHG emissions and energy usage from transportation, regular production, and remanufacturing operations conducted by manufacturer and solve the model to get the maximum annual joint total profit for both parties. The model also considers price-dependent return rate and determine it as a decision variable as well as number of shipments from collector to manufacturer and optimal cycle period. An iterative procedure is proposed to determine the optimal solutions. We present a numerical example to illustrate the application of the model and perform a sensitivity analysis to study the effects of the changes in environmental related costs on the model’s decision.

Nutrient enrichment, biodiversity loss, and consequent declines in ecosystem productivity.

PubMed

Isbell, Forest; Reich, Peter B; Tilman, David; Hobbie, Sarah E; Polasky, Stephen; Binder, Seth

2013-07-16

Anthropogenic drivers of environmental change often have multiple effects, including changes in biodiversity, species composition, and ecosystem functioning. It remains unknown whether such shifts in biodiversity and species composition may, themselves, be major contributors to the total, long-term impacts of anthropogenic drivers on ecosystem functioning. Moreover, although numerous experiments have shown that random losses of species impact the functioning of ecosystems, human-caused losses of biodiversity are rarely random. Here we use results from long-term grassland field experiments to test for direct effects of chronic nutrient enrichment on ecosystem productivity, and for indirect effects of enrichment on productivity mediated by resultant species losses. We found that ecosystem productivity decreased through time most in plots that lost the most species. Chronic nitrogen addition also led to the nonrandom loss of initially dominant native perennial C4 grasses. This loss of dominant plant species was associated with twice as great a loss of productivity per lost species than occurred with random species loss in a nearby biodiversity experiment. Thus, although chronic nitrogen enrichment initially increased productivity, it also led to loss of plant species, including initially dominant species, which then caused substantial diminishing returns from nitrogen fertilization. In contrast, elevated CO2 did not decrease grassland plant diversity, and it consistently promoted productivity over time. Our results support the hypothesis that the long-term impacts of anthropogenic drivers of environmental change on ecosystem functioning can strongly depend on how such drivers gradually decrease biodiversity and restructure communities.

Marine biotechnology for production of food ingredients.

PubMed

Rasmussen, Rosalee S; Morrissey, Michael T

2007-01-01

The marine world represents a largely untapped reservoir of bioactive ingredients that can be applied to numerous aspects of food processing, storage, and fortification. Due to the wide range of environments they survive in, marine organisms have developed unique properties and bioactive compounds that, in some cases, are unparalleled by their terrestrial counterparts. Enzymes extracted from fish and marine microorganisms can provide numerous advantages over traditional enzymes used in food processing due to their ability to function at extremes of temperature and pH. Fish proteins such as collagens and their gelatin derivatives operate at relatively low temperatures and can be used in heat-sensitive processes such as gelling and clarifying. Polysaccharides derived from algae, including algins, carrageenans, and agar, are widely used for their ability to form gels and act as thickeners and stabilizers in a variety of foods. Besides applications in food processing, a number of marine-derived compounds, such as omega-3 polyunsaturated fatty acids and photosynthetic pigments, are important to the nutraceutical industry. These bioactive ingredients provide a myriad of health benefits, including reduction of coronary heart disease, anticarcinogenic and anti-inflammatory activity. Despite the vast possibilities for the use of marine organisms in the food industry, tools of biotechnology are required for successful cultivation and isolation of these unique bioactive compounds. In this chapter, recent developments and upcoming areas of research that utilize advances in biotechnology in the production of food ingredients from marine sources are introduced and discussed.

Domestication of the Cardiac Mitochondrion for Energy Conversion

PubMed Central

Balaban, Robert S.

2009-01-01

The control of mitochondria energy conversion by cytosolic processes is reviewed. The nature of the cytosolic and mitochondrial potential energy homeostasis over wide ranges of energy utilization is reviewed and the consequences of this homeostasis in the control network are discussed. An analysis of the major candidate cytosolic signaling molecules ADP, Pi and Ca2+ are reviewed based on the magnitude and source of the cytosolic concentration changes as well as the potential targets of action within the mitochondrial energy conversion system. Based on this analysis, Ca2+ is the best candidate as a cytosolic signaling molecule for this process based on its ability to act as both a feed-forward and feed-back indicator of ATP hydrolysis and numerous targets within the matrix to provide a balanced activation of ATP production. These targets include numerous dehydrogenases and the F1-F0-ATPase. Pi is also a good candidate since it is an early signal of a mismatch between cytosolic ATP production and ATP synthesis in the presence of creatine kinase and has multiple targets within oxidative phosphorylation including NADH generation, electron flux in the cytochrome chain and a substrate for the F1-F0-ATPase. The mechanism of the coordinated activation of oxidative phosphorylation by these signaling molecules in discussed in light of the recent discoveries of extensive protein phosphorylation sites and other post-translational modifications. From this review it is clear that the control network associated with the maintenance of the cytosolic potential energy homeostasis is extremely complex with multiple pathways orchestrated to balance the sinks and sources in this system. New tools are needed to image and monitor metabolites within subcellular compartments to resolve many of these issues as well as the functional characterization of the numerous matrix post-translational events being discovered along with the enzymatic processes generating and removing these protein modifications. PMID:19265699

Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water.

PubMed

de Jongh, Cindy M; Kooij, Pascal J F; de Voogt, Pim; ter Laak, Thomas L

2012-06-15

Numerous studies describe the presence of pharmaceuticals in the water cycle, while their transformation products are usually not included. In the current study 17 common pharmaceuticals and 9 transformation products were monitored in the Dutch waters, including surface waters, pre-treated surface waters, river bank filtrates, two groundwater samples affected by surface water and drinking waters. In these samples, 12 pharmaceuticals and 7 transformation products were present. Concentrations were generally highest in surface waters, intermediate in treated surface waters and river bank filtrates and lowest or not detected in produced drinking water. However, the concentrations of phenazone and its environmental transformation product AMPH were significantly higher in river bank filtrates, which is likely due to historical contamination. Fairly constant ratios were observed between concentrations of transformation products and parent pharmaceuticals. This might enable prediction of concentrations of transformation products from concentrations of parent pharmaceuticals. The toxicological relevance of the observed pharmaceuticals and transformation products was assessed by deriving (i) a substance specific provisional guideline value (pGLV) and (ii) a group pGLV for groups of related compounds were under the assumption of additivity of effects within each group. A substantial margin exists between the maximum summed concentrations of these compounds present in different water types and the derived (group) pGLVs. Based on the results of this limited screening campaign no adverse health effects of the studied compounds are expected in (sources of) drinking water in the Netherlands. The presence of transformation products with similar pharmacological activities and concentration levels as their parents illustrates the relevance of monitoring transformation products, and including these in risk assessment. More thorough monitoring yielding information on statistical uncertainty and variability in time and space, and research on possible synergistic effects of low concentration mixtures of compounds belonging to similar pharmacological classes require attention. Copyright © 2012 Elsevier B.V. All rights reserved.

Performance analysis of the toroidal field ITER production conductors

NASA Astrophysics Data System (ADS)

Breschi, M.; Macioce, D.; Devred, A.

2017-05-01

The production of the superconducting cables for the toroidal field (TF) magnets of the ITER machine has recently been completed at the manufacturing companies selected during the previous qualification phase. The quality assurance/quality control programs that have been implemented to ensure production uniformity across numerous suppliers include performance tests of several conductor samples from selected unit lengths. The short full-size samples (4 m long) were subjected to DC and AC tests in the SULTAN facility at CRPP in Villigen, Switzerland. In a previous work the results of the tests of the conductor performance qualification samples were reported. This work reports the analyses of the results of the tests of the production conductor samples. The results reported here concern the values of current sharing temperature, critical current, effective strain and n-value from the DC tests and the energy dissipated per cycle from the AC loss tests. A detailed comparison is also presented between the performance of the conductors and that of their constituting strands.

Recent advances in engineering propionyl-CoA metabolism for microbial production of value-added chemicals and biofuels.

PubMed

Srirangan, Kajan; Bruder, Mark; Akawi, Lamees; Miscevic, Dragan; Kilpatrick, Shane; Moo-Young, Murray; Chou, C Perry

2017-09-01

Diminishing fossil fuel reserves and mounting environmental concerns associated with petrochemical manufacturing practices have generated significant interests in developing whole-cell biocatalytic systems for the production of value-added chemicals and biofuels. Although acetyl-CoA is a common natural biogenic precursor for the biosynthesis of numerous metabolites, propionyl-CoA is unpopular and non-native to most organisms. Nevertheless, with its C3-acyl moiety as a discrete building block, propionyl-CoA can serve as another key biogenic precursor to several biological products of industrial importance. As a result, engineering propionyl-CoA metabolism, particularly in genetically tractable hosts with the use of inexpensive feedstocks, has paved an avenue for novel biomanufacturing. Herein, we present a systematic review on manipulation of propionyl-CoA metabolism as well as relevant genetic and metabolic engineering strategies for microbial production of value-added chemicals and biofuels, including odd-chain alcohols and organic acids, bio(co)polymers and polyketides. [Formula: see text].

Metabolic engineering of yeast for lignocellulosic biofuel production.

PubMed

Jin, Yong-Su; Cate, Jamie Hd

2017-12-01

Production of biofuels from lignocellulosic biomass remains an unsolved challenge in industrial biotechnology. Efforts to use yeast for conversion face the question of which host organism to use, counterbalancing the ease of genetic manipulation with the promise of robust industrial phenotypes. Saccharomyces cerevisiae remains the premier host for metabolic engineering of biofuel pathways, due to its many genetic, systems and synthetic biology tools. Numerous engineering strategies for expanding substrate ranges and diversifying products of S. cerevisiae have been developed. Other yeasts generally lack these tools, yet harbor superior phenotypes that could be exploited in the harsh processes required for lignocellulosic biofuel production. These include thermotolerance, resistance to toxic compounds generated during plant biomass deconstruction, and wider carbon consumption capabilities. Although promising, these yeasts have yet to be widely exploited. By contrast, oleaginous yeasts such as Yarrowia lipolytica capable of producing high titers of lipids are rapidly advancing in terms of the tools available for their metabolic manipulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

PubMed

Dückert, Heiko; Pries, Verena; Khedkar, Vivek; Menninger, Sascha; Bruss, Hanna; Bird, Alexander W; Maliga, Zoltan; Brockmeyer, Andreas; Janning, Petra; Hyman, Anthony; Grimme, Stefan; Schürmann, Markus; Preut, Hans; Hübel, Katja; Ziegler, Slava; Kumar, Kamal; Waldmann, Herbert

2011-12-25

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is, in particular, met by the scaffolds of natural products selected in evolution. The synthesis of natural product-inspired compound collections calls for efficient reaction sequences that preferably combine multiple individual transformations in one operation. Here we report the development of a one-pot, twelve-step cascade reaction sequence that includes nine different reactions and two opposing kinds of organocatalysis. The cascade sequence proceeds within 10-30 min and transforms readily available substrates into complex indoloquinolizines that resemble the core tetracyclic scaffold of numerous polycyclic indole alkaloids. Biological investigation of a corresponding focused compound collection revealed modulators of centrosome integrity, termed centrocountins, which caused fragmented and supernumerary centrosomes, chromosome congression defects, multipolar mitotic spindles, acentrosomal spindle poles and multipolar cell division by targeting the centrosome-associated proteins nucleophosmin and Crm1.

Optimal pricing and marketing planning for deteriorating items

PubMed Central

Moosavi Tabatabaei, Seyed Reza; Sadjadi, Seyed Jafar; Makui, Ahmad

2017-01-01

Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and after-sales service expenditures. The proposed model is formulated as a geometric programming with 5 degrees of difficulty and the problem is solved using the recent advances in optimization techniques. The study is supported by several numerical examples and sensitivity analysis is performed to analyze the effects of the changes in different parameters on the optimal solution. The preliminary results indicate that with the change in parameters influencing on demand, inventory holding, inventory deteriorating and set-up costs change and also significantly affect total revenue. PMID:28306750

Bio-inspired organic field effect transistors

NASA Astrophysics Data System (ADS)

Irimia-Vladu, Mihai; Troshin, Pavel A.; Schwabegger, Günther; Bodea, Marius; Schwödiauer, Reinhard; Fergus, Jeffrey W.; Razumov, Vladimir; Bauer, Siegfried; Sariciftci, Niyazi Serdar

2010-08-01

Two major concerns in the world nowadays are the plastic consumption and waste. Because to the economic growth and the incessant demand of plastics in developing countries, plastics consumption is projected to increase by a factor of two to three during the actual decade1. As an intuitive example, the amount of municipal solid waste (estimated per person per year) averages ~440 kg for China, ~550 kg for the European Union and ~790 kg for the United States, with almost 50% of the waste being electronic products and plastics1,2. Green technology based on biodegradable/compostable materials is perceived as an ultimate goal for solving waste problems. Currently there are numerous efforts for producing compostable plastic materials for applications in daily life products, such as plastic bags and disposable dishware. When such low-end products are fabricated with compostable materials, electronics included in such goods should be also based on materials that are easily compostable.

Polymerase chain reaction technology as analytical tool in agricultural biotechnology.

PubMed

Lipp, Markus; Shillito, Raymond; Giroux, Randal; Spiegelhalter, Frank; Charlton, Stacy; Pinero, David; Song, Ping

2005-01-01

The agricultural biotechnology industry applies polymerase chain reaction (PCR) technology at numerous points in product development. Commodity and food companies as well as third-party diagnostic testing companies also rely on PCR technology for a number of purposes. The primary use of the technology is to verify the presence or absence of genetically modified (GM) material in a product or to quantify the amount of GM material present in a product. This article describes the fundamental elements of PCR analysis and its application to the testing of grains. The document highlights the many areas to which attention must be paid in order to produce reliable test results. These include sample preparation, method validation, choice of appropriate reference materials, and biological and instrumental sources of error. The article also discusses issues related to the analysis of different matrixes and the effect they may have on the accuracy of the PCR analytical results.

Synthetic biology approaches: Towards sustainable exploitation of marine bioactive molecules.

PubMed

Seghal Kiran, G; Ramasamy, Pasiyappazham; Sekar, Sivasankari; Ramu, Meenatchi; Hassan, Saqib; Ninawe, A S; Selvin, Joseph

2018-06-01

The discovery of genes responsible for the production of bioactive metabolites via metabolic pathways combined with the advances in synthetic biology tools, has allowed the establishment of numerous microbial cell factories, for instance the yeast cell factories, for the manufacture of highly useful metabolites from renewable biomass. Genome mining and metagenomics are two platforms provide base-line data for reconstruction of genomes and metabolomes which is based in the development of synthetic/semi-synthetic genomes for marine natural products discovery. Engineered biofilms are being innovated on synthetic biology platform using genetic circuits and cell signalling systems as represillators controlling biofilm formation. Recombineering is a process of homologous recombination mediated genetic engineering, includes insertion, deletion or modification of any sequence specifically. Although this discipline considered new to the scientific domain, this field has now developed as promising endeavor on the accomplishment of sustainable exploitation of marine natural products. Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical alternatives assessment: the case of flame retardants.

PubMed

Howard, Gregory J

2014-12-01

Decisions on chemical substitution are made rapidly and by many stakeholders; these decisions may have a direct impact on consumer exposures, and, when a hazard exists, to consumer risks. Flame retardants (FRs) represent particular challenges, including very high production volumes, designed-in persistence, and often direct consumer exposure. Newer FR products, as with other industrial chemicals, typically lack data on hazard and exposure, and in many cases even basic information on structure and use in products is unknown. Chemical alternatives assessment (CAA) provides a hazard-focused approach to distinguishing between possible substitutions; variations on this process are used by several government and numerous corporate entities. By grouping chemicals according to functional use, some information on exposure potential can be inferred, allowing for decisions based on those hazard properties that are most distinguishing. This approach can help prevent the "regrettable substitution" of one chemical with another of equal, or even higher, risk. Copyright © 2014 Elsevier Ltd. All rights reserved.

Natural antioxidants as food and feed additives to promote health benefits and quality of meat products: A review.

PubMed

Jiang, Jiang; Xiong, Youling L

2016-10-01

Fresh and processed meats offer numerous nutritional and health benefits and provide unique eating satisfaction in the lifestyle of the modern society. However, consumption of red meat including processed products is subjected to increasing scrutiny due to the health risks associated with cytotoxins that potentially could be generated during meat preparation. Evidence from recent studies suggests free radical pathways as a plausible mechanism for toxin formation, and antioxidants have shown promise to mitigate process-generated chemical hazards. The present review discusses the involvements of lipid and protein oxidation in meat quality, nutrition, safety, and organoleptic properties; animal production and meat processing strategies which incorporate natural antioxidants to enhance the nutritional and health benefits of meat; and the application of mixed or purified natural antioxidants to eliminate or minimize the formation of carcinogens for chemical safety of cooked and processed meats. Copyright © 2016. Published by Elsevier Ltd.

General equilibrium incidence of energy taxation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solow, J.L.

1984-04-01

The pervasiveness of energy in the economy and the numerous ways in which energy taxation can distort resource allocations implies the necessity of a general equilibrium approach to the question of energy tax incidence. The author presents a general equilibrium model that accounts for domestic energy production and energy imports, direct energy consumption and use of energy as an intermediate good, and production of energy intensive and nonenergy intensive goods. He examines the incidence of three broadly-based energy taxation policies: a tax on all energy consumption, a subsidy to domestic energy production, and a tariff on energy imports. The subsidy,more » although not a revenue raising measure, is included because, like the other policies, it acts to reduce energy imports. Such a measure may be of interest by reducing reliance on unstable foreign sources of supply. 12 references, 3 tables.« less

From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics

PubMed Central

Silber, Johanna; Kramer, Annemarie; Labes, Antje; Tasdemir, Deniz

2016-01-01

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics. PMID:27455283

Lake States Aspen Productivity Following Soil Compaction and Organic Matter Removal

Treesearch

Douglas M. Stone

2002-01-01

Aspen (Populus tremuloides Michx. and P. grandidentata Michx.) provides wood products, watershed protection, and wildlife habitat for numerous game and non-game species across the northern Great Lakes region. Sustaining the productivity of these ecosystems requires maintaining soil productivity. Management activities that decrease...

Chiral thiazoline and thiazole building blocks for the synthesis of peptide-derived natural products.

PubMed

Just-Baringo, Xavier; Albericio, Fernando; Alvarez, Mercedes

2014-01-01

Thiazoline and thiazole heterocycles are privileged motifs found in numerous peptide-derived natural products of biological interest. During the last decades, the synthesis of optically pure building blocks has been addressed by numerous groups, which have developed a plethora of strategies to that end. Efficient and reliable methodologies that are compatible with the intricate and capricious architectures of natural products are a must to further develop their science. Structure confirmation, structure-activity relationship studies and industrial production are fields of paramount importance that require these robust methodologies in order to successfully bring natural products into the clinic. Today's chemist toolbox is assorted with many powerful methods for chiral thiazoline and thiazole synthesis. Ranging from biomimetic approaches to stereoselective alkylations, one is likely to find a suitable method for their needs.

Evaluation of Biogenic and Fire Emissions in a Global Chemistry Model with NOMADSS, DC3 and SEAC4RS observations

NASA Astrophysics Data System (ADS)

Emmons, L. K.; Wiedinmyer, C.; Park, M.; Kaser, L.; Apel, E. C.; Guenther, A. B.

2014-12-01

Numerous measurements of compounds produced by biogenic and fire emissions were made during several recent field campaigns in the southeast United States, providing a unique data set for emissions and chemical model evaluation. The NCAR Community Atmosphere Model with Chemistry (CAM-chem) is coupled to the Community Land Model (CLM), which includes the biogenic emissions model MEGAN-v2.1, allowing for online calculation of emissions from vegetation for 150 compounds. Simulations of CAM-chem for summers 2012 and 2013 are evaluated with the aircraft and ground-based observations from DC3, NOMADSS and SEAC4RS. Comparison of directly emitted biogenic species, such as isoprene, terpenes, methanol and acetone, are used to evaluate the MEGAN emissions. Evaluation of oxidation products, including methyl vinyl ketone (MVK), methacrolein, formaldehyde, and other oxygenated VOCs are used to test the model chemistry mechanism. In addition, several biomass burning inventories are used in the model, including FINN, QFED, and FLAMBE, and are compared for their impact on atmospheric composition and ozone production, and evaluated with the aircraft observations.

Inner Space Perturbation Theory in Matrix Product States: Replacing Expensive Iterative Diagonalization.

PubMed

Ren, Jiajun; Yi, Yuanping; Shuai, Zhigang

2016-10-11

We propose an inner space perturbation theory (isPT) to replace the expensive iterative diagonalization in the standard density matrix renormalization group theory (DMRG). The retained reduced density matrix eigenstates are partitioned into the active and secondary space. The first-order wave function and the second- and third-order energies are easily computed by using one step Davidson iteration. Our formulation has several advantages including (i) keeping a balance between the efficiency and accuracy, (ii) capturing more entanglement with the same amount of computational time, (iii) recovery of the standard DMRG when all the basis states belong to the active space. Numerical examples for the polyacenes and periacene show that the efficiency gain is considerable and the accuracy loss due to the perturbation treatment is very small, when half of the total basis states belong to the active space. Moreover, the perturbation calculations converge in all our numerical examples.

New method to evaluate the 7Li(p, n)7Be reaction near threshold

NASA Astrophysics Data System (ADS)

Herrera, María S.; Moreno, Gustavo A.; Kreiner, Andrés J.

2015-04-01

In this work a complete description of the 7Li(p, n)7Be reaction near threshold is given using center-of-mass and relative coordinates. It is shown that this standard approach, not used before in this context, leads to a simple mathematical representation which gives easy access to all relevant quantities in the reaction and allows a precise numerical implementation. It also allows in a simple way to include proton beam-energy spread affects. The method, implemented as a C++ code, was validated both with numerical and experimental data finding a good agreement. This tool is also used here to analyze scattered published measurements such as (p, n) cross sections, differential and total neutron yields for thick targets. Using these data we derive a consistent set of parameters to evaluate neutron production near threshold. Sensitivity of the results to data uncertainty and the possibility of incorporating new measurements are also discussed.

Wind-US User's Guide, Version 2.0

NASA Technical Reports Server (NTRS)

Towne, Charles E.

2009-01-01

Wind-US is a computational platform which may be used to numerically solve various sets of equations governing physical phenomena. Currently, the code supports the solution of the Euler and Navier-Stokes equations of fluid mechanics, along with supporting equation sets governing turbulent and chemically reacting flows. Wind-US is a product of the NPARC Alliance, a partnership between the NASA Glenn Research Center (GRC) and the Arnold Engineering Development Center (AEDC) dedicated to the establishment of a national, applications-oriented flow simulation capability. The Boeing Company has also been closely associated with the Alliance since its inception, and represents the interests of the NPARC User's Association. The "Wind-US User's Guide" describes the operation and use of Wind-US, including: a basic tutorial; the physical and numerical models that are used; the boundary conditions; monitoring convergence; the files that are read and/or written; parallel execution; and a complete list of input keywords and test options.

3D numerical simulation of free surface shape during the crystal growth of floating zone (FZ) silicon

NASA Astrophysics Data System (ADS)

Han, Xue-Feng; Liu, Xin; Nakano, Satoshi; Harada, Hirofumi; Miyamura, Yoshiji; Kakimoto, Koichi

2018-02-01

In FZ growth processes, the stability of the free surface is important in the production of single crystal silicon with high quality. To investigate the shape of the free surface in the FZ silicon crystal growth, a 3D numerical model that included gas and liquid phases was developed. In this present study, 3D Young-Laplacian equations have been solved using the Volume of Fluid (VOF) Model. Using this new model, we predicted the 3D shape of the free surface in FZ silicon crystal growth. The effect of magnetic pressure on shape of free surface has been considered. In particular, the free surface of the eccentric growth model, which could not be previously solved using the 2D Young-Laplacian equations, was solved using the VOF model. The calculation results are validated by the experimental results.

Competition for vitamin B1 (thiamin) structures numerous ecological interactions.

PubMed

Kraft, Clifford E; Angert, Esther R

2017-06-01

Thiamin (vitamin B1) is a cofactor required for essential biochemical reactions in all living organisms, yet free thiamin is scarce in the environment. The diversity of biochemical pathways involved in the acquisition, degradation, and synthesis of thiamin indicates that organisms have evolved numerous ecological strategies for meeting this nutritional requirement. In this review we synthesize information from multiple disciplines to show how the complex biochemistry of thiamin influences ecological outcomes of interactions between organisms in environments ranging from the open ocean and the Australian outback to the gastrointestinal tract of animals. We highlight population and ecosystem responses to the availability or absence of thiamin. These include widespread mortality of fishes, birds, and mammals, as well as the thiamin-dependent regulation of ocean productivity. Overall, we portray thiamin biochemistry as the foundation for molecularly mediated ecological interactions that influence survival and abundance of a vast array of organisms.

Numerical Simulation Applications in the Design of EGS Collab Experiment 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnston, Henry; White, Mark D.; Fu, Pengcheng

The United States Department of Energy, Geothermal Technologies Office (GTO) is funding a collaborative investigation of enhanced geothermal systems (EGS) processes at the meso-scale. This study, referred to as the EGS Collab project, is a unique opportunity for scientists and engineers to investigate the creation of fracture networks and circulation of fluids across those networks under in-situ stress conditions. The EGS Collab project is envisioned to comprise three experiments and the site for the first experiment is on the 4850 Level (4,850 feet below ground surface) in phyllite of the Precambrian Poorman formation, at the Sanford Underground Research Facility, locatedmore » at the former Homestake Gold Mine, in Lead, South Dakota. Principal objectives of the project are to develop a number of intermediate-scale field sites and to conduct well-controlled in situ experiments focused on rock fracture behavior and permeability enhancement. Data generated during these experiments will be compared against predictions of a suite of computer codes specifically designed to solve problems involving coupled thermal, hydrological, geomechanical, and geochemical processes. Comparisons between experimental and numerical simulation results will provide code developers with direction for improvements and verification of process models, build confidence in the suite of available numerical tools, and ultimately identify critical future development needs for the geothermal modeling community. Moreover, conducting thorough comparisons of models, modelling approaches, measurement approaches and measured data, via the EGS Collab project, will serve to identify techniques that are most likely to succeed at the Frontier Observatory for Research in Geothermal Energy (FORGE), the GTO's flagship EGS research effort. As noted, outcomes from the EGS Collab project experiments will serve as benchmarks for computer code verification, but numerical simulation additionally plays an essential role in designing these meso-scale experiments. This paper describes specific numerical simulations supporting the design of Experiment 1, a field test involving hydraulic stimulation of two fractures from notched sections of the injection borehole and fluid circulation between sub-horizontal injection and production boreholes in each fracture individually and collectively, including the circulation of chilled water. Whereas the mine drift allows for accurate and close placement of monitoring instrumentation to the developed fractures, active ventilation in the drift cooled the rock mass within the experimental volume. Numerical simulations were executed to predict seismic events and magnitudes during stimulation, initial fracture orientations for smooth horizontal wellbores, pressure requirements for fracture initiation from notched wellbores, fracture propagation during stimulation between the injection and production boreholes, tracer travel times between the injection and production boreholes, produced fluid temperatures with chilled water injections, pressure limits on fluid circulation to avoid fracture growth, temperature environment surrounding the 4850 Level drift, and fracture propagation within a stress field altered by drift excavation, ventilation cooling, and dewatering.« less

The Academic RVU: Ten Years Developing a Metric for and Financially Incenting Academic Productivity at Oregon Health & Science University.

PubMed

Ma, O John; Hedges, Jerris R; Newgard, Craig D

2017-08-01

Established metrics reward academic faculty for clinical productivity. Few data have analyzed a bonus model to measure and reward academic productivity. This study's objective was to describe development and use of a departmental academic bonus system for incenting faculty scholarly and educational productivity. This cross-sectional study analyzed a departmental bonus system among emergency medicine academic faculty at Oregon Health & Science University, including growth from 2005 to 2015. All faculty members with a primary appointment were eligible for participation. Each activity was awarded points based on a predetermined education or scholarly point scale. Faculty members accumulated points based on their activity (numerator), and the cumulative points of all faculty were the denominator. Variables were individual faculty member (deidentified), academic year, bonus system points, bonus amounts awarded, and measures of academic productivity. Data were analyzed using descriptive statistics, including measures of variance. The total annual financial bonus pool ranged from $211,622 to $274,706. The median annual per faculty academic bonus remained fairly constant over time ($3,980 in 2005-2006 vs. $4,293 in 2014-2015), with most change at the upper quartile of academic bonus (max bonus $16,920 in 2005-2006 vs. $39,207 in 2014-2015). Bonuses rose linearly among faculty in the bottom three quartiles of academic productivity, but increased exponentially in the 75th to 100th percentile. Faculty academic productivity can be measured and financially rewarded according to an objective academic bonus system. The "academic point" used to measure productivity functions as an "academic relative value unit."

A single-vendor and a single-buyer integrated inventory model with ordering cost reduction dependent on lead time

NASA Astrophysics Data System (ADS)

Vijayashree, M.; Uthayakumar, R.

2017-09-01

Lead time is one of the major limits that affect planning at every stage of the supply chain system. In this paper, we study a continuous review inventory model. This paper investigates the ordering cost reductions are dependent on lead time. This study addressed two-echelon supply chain problem consisting of a single vendor and a single buyer. The main contribution of this study is that the integrated total cost of the single vendor and the single buyer integrated system is analyzed by adopting two different (linear and logarithmic) types ordering cost reductions act dependent on lead time. In both cases, we develop effective solution procedures for finding the optimal solution and then illustrative numerical examples are given to illustrate the results. The solution procedure is to determine the optimal solutions of order quantity, ordering cost, lead time and the number of deliveries from the single vendor and the single buyer in one production run, so that the integrated total cost incurred has the minimum value. Ordering cost reduction is the main aspect of the proposed model. A numerical example is given to validate the model. Numerical example solved by using Matlab software. The mathematical model is solved analytically by minimizing the integrated total cost. Furthermore, the sensitivity analysis is included and the numerical examples are given to illustrate the results. The results obtained in this paper are illustrated with the help of numerical examples. The sensitivity of the proposed model has been checked with respect to the various major parameters of the system. Results reveal that the proposed integrated inventory model is more applicable for the supply chain manufacturing system. For each case, an algorithm procedure of finding the optimal solution is developed. Finally, the graphical representation is presented to illustrate the proposed model and also include the computer flowchart in each model.

Adaptive Numerical Dissipative Control in High Order Schemes for Multi-D Non-Ideal MHD

NASA Technical Reports Server (NTRS)

Yee, H. C.; Sjoegreen, B.

2004-01-01

The goal is to extend our adaptive numerical dissipation control in high order filter schemes and our new divergence-free methods for ideal MHD to non-ideal MHD that include viscosity and resistivity. The key idea consists of automatic detection of different flow features as distinct sensors to signal the appropriate type and amount of numerical dissipation/filter where needed and leave the rest of the region free of numerical dissipation contamination. These scheme-independent detectors are capable of distinguishing shocks/shears, flame sheets, turbulent fluctuations and spurious high-frequency oscillations. The detection algorithm is based on an artificial compression method (ACM) (for shocks/shears), and redundant multi-resolution wavelets (WAV) (for the above types of flow feature). These filter approaches also provide a natural and efficient way for the minimization of Div(B) numerical error. The filter scheme consists of spatially sixth order or higher non-dissipative spatial difference operators as the base scheme for the inviscid flux derivatives. If necessary, a small amount of high order linear dissipation is used to remove spurious high frequency oscillations. For example, an eighth-order centered linear dissipation (AD8) might be included in conjunction with a spatially sixth-order base scheme. The inviscid difference operator is applied twice for the viscous flux derivatives. After the completion of a full time step of the base scheme step, the solution is adaptively filtered by the product of a 'flow detector' and the 'nonlinear dissipative portion' of a high-resolution shock-capturing scheme. In addition, the scheme independent wavelet flow detector can be used in conjunction with spatially compact, spectral or spectral element type of base schemes. The ACM and wavelet filter schemes using the dissipative portion of a second-order shock-capturing scheme with sixth-order spatial central base scheme for both the inviscid and viscous MHD flux derivatives and a fourth-order Runge-Kutta method are denoted.

The yeast Saccharomyces cerevisiae- the main character in beer brewing.

PubMed

Lodolo, Elizabeth J; Kock, Johan L F; Axcell, Barry C; Brooks, Martin

2008-11-01

Historically, mankind and yeast developed a relationship that led to the discovery of fermented beverages. Numerous inventions have led to improved technologies and capabilities to optimize fermentation technology on an industrial scale. The role of brewing yeast in the beer-making process is reviewed and its importance as the main character is highlighted. On considering the various outcomes of functions in a brewery, it has been found that these functions are focused on supporting the supply of yeast requirements for fermentation and ultimately to maintain the integrity of the product. The functions/processes include: nutrient supply to the yeast (raw material supply for brewhouse wort production); utilities (supply of water, heat and cooling); quality assurance practices (hygiene practices, microbiological integrity measures and other specifications); plant automation (vessels, pipes, pumps, valves, sensors, stirrers and centrifuges); filtration and packaging (product preservation until consumption); distribution (consumer supply); and marketing (consumer awareness). Considering this value chain of beer production and the 'bottle neck' during production, the spotlight falls on fermentation, the age-old process where yeast transforms wort into beer.

Community health centers employ diverse staffing patterns, which can provide productivity lessons for medical practices.

PubMed

Ku, Leighton; Frogner, Bianca K; Steinmetz, Erika; Pittman, Patricia

2015-01-01

Community health centers are at the forefront of ambulatory care practices in their use of nonphysician clinicians and team-based primary care. We examined medical staffing patterns, the contributions of different types of staff to productivity, and the factors associated with staffing at community health centers across the United States. We identified four different staffing patterns: typical, high advanced-practice staff, high nursing staff, and high other medical staff. Overall, productivity per staff person was similar across the four staffing patterns. We found that physicians make the greatest contributions to productivity, but advanced-practice staff, nurses, and other medical staff also contribute. Patterns of community health center staffing are driven by numerous factors, including the concentration of clinicians in communities, nurse practitioner scope-of-practice laws, and patient characteristics such as insurance status. Our findings suggest that other group medical practices could incorporate more nonphysician staff without sacrificing productivity and thus profitability. However, the new staffing patterns that evolve may be affected by characteristics of the practice location or the types of patients served. Project HOPE—The People-to-People Health Foundation, Inc.

Heterologous Production of Curcuminoids

PubMed Central

Rodrigues, J. L.; Prather, K. L. J.

2015-01-01

SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attractive targets for heterologous production and metabolic engineering. The understanding of biosynthesis of curcuminoids in turmeric made remarkable advances in the last decade, and as a result, several efforts to produce them in heterologous organisms have been reported. The artificial biosynthetic pathway (e.g., in Escherichia coli) can start with the supplementation of the amino acid tyrosine or phenylalanine or of carboxylic acids and lead to the production of several natural curcuminoids. Unnatural carboxylic acids can also be supplemented as precursors and lead to the production of unnatural compounds with possibly novel therapeutic properties. In this paper, we review the natural conversion of curcuminoids in turmeric and their production by E. coli using an artificial biosynthetic pathway. We also explore the potential of other enzymes discovered recently or already used in other similar biosynthetic pathways, such as flavonoids and stilbenoids, to increase curcuminoid yield and activity. PMID:25631288

Production of Copper as a Complex Mining and Metallurgical Processing System in Polish Copper Mines of the Legnica-Glogów Copper Belt

NASA Astrophysics Data System (ADS)

Malewski, Jerzy

2017-12-01

Geological and technological conditions of Cu production in the Polish copper mines of the Legnica-Glogów Copper Belt are presented. Cu production is recognized as a technological fractal consisting of subsystems for mineral exploration, ore extraction and processing, and metallurgical treatment. Qualitative and quantitative models of these operations have been proposed, including estimation of their costs of process production. Numerical calculations of such a system have been performed, which allow optimize the system parameters according to economic criteria under variable Cu mineralization in the ore deposit. The main objective of the study is to develop forecasting tool for analysis of production efficiency in domestic copper mines based on available sources of information. Such analyses are primarily of social value, allowing for assessment of the efficiency of management of local mineral resources in the light of current technological and market constraints. At the same time, this is a concept of the system analysis method to manage deposit exploitation on operational and strategic level.

The effect of sudden server breakdown on the performance of a disassembly line

NASA Astrophysics Data System (ADS)

Udomsawat, Gun; Gupta, Surendra M.

2005-11-01

Product and material recovery relies on the disassembly process to separate target components or materials from the end-of-life (EOL) products. Disassembly line is especially effective when products in large quantity are disassembled. Unlike an assembly line, a disassembly line is more complex and is subjected to numerous uncertainties including stochastic and multi-level arrivals of component demands, stochastic arrival times for EOL products, and process interruption due to equipment failure. These factors seriously impair the control mechanism in the disassembly line. A common production control mechanism is the traditional push system (TPS). TPS responds to the aforementioned complications by carrying substantial amounts of inventories. An alternative control mechanism is a newly developed multi-kanban pull system (MKS) that relies on dynamic routing of kanbans, which tends to minimize the system's inventories while maintaining demand serviceability. In this paper we explore the impact of sudden breakdown of server on the performance of a disassembly line. We compare the overall performances of the TPS and MKS by considering two scenarios. We present the solution procedure and results for these cases.

Viral pathogen discovery

PubMed Central

Chiu, Charles Y

2015-01-01

Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remain to be addressed, including the bioinformatics analysis and interpretation of large datasets, these technologies have been successful in rapidly identifying emerging outbreak threats, screening vaccines and other biological products for microbial contamination, and discovering novel viruses associated with both acute and chronic illnesses. Downstream studies such as genome assembly, epidemiologic screening, and a culture system or animal model of infection are necessary to establish an association of a candidate pathogen with disease. PMID:23725672

Bee products prevent agrichemical-induced oxidative damage in fish.

PubMed

Ferreira, Daiane; Rocha, Helio Carlos; Kreutz, Luiz Carlos; Loro, Vania Lucia; Marqueze, Alessandra; Koakoski, Gessi; da Rosa, João Gabriel Santos; Gusso, Darlan; Oliveira, Thiago Acosta; de Abreu, Murilo Sander; Barcellos, Leonardo José Gil

2013-01-01

In southern South America and other parts of the world, aquaculture is an activity that complements agriculture. Small amounts of agrichemicals can reach aquaculture ponds, which results in numerous problems caused by oxidative stress in non-target organisms. Substances that can prevent or reverse agrichemical-induced oxidative damage may be used to combat these effects. This study includes four experiments. In each experiment, 96 mixed-sex, 6-month-old Rhamdia quelen (118±15 g) were distributed into eight experimental groups: a control group that was not exposed to contaminated water, three groups that were exposed to various concentrations of bee products, three groups that were exposed to various concentrations of bee products plus tebuconazole (TEB; Folicur 200 CE™) and a group that was exposed to 0.88 mg L(-1) of TEB alone (corresponding to 16.6% of the 96-h LC50). We show that waterborne bee products, including royal jelly (RJ), honey (H), bee pollen (BP) and propolis (P), reversed the oxidative damage caused by exposure to TEB. These effects were likely caused by the high polyphenol contents of these bee-derived compounds. The most likely mechanism of action for the protective effects of bee products against tissue oxidation and the resultant damage is that the enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) are increased.

Bioactive natural products in cancer prevention and therapy: Progress and promise.

PubMed

Bishayee, Anupam; Sethi, Gautam

2016-10-01

Natural products represent a rich source for the discovery and development of cancer preventive and anticancer drugs. Nearly, 80% of all drugs approved by the United States Food and Drug Administration during the last three decades for cancer therapy are either natural products per se or are based thereon, or mimicked natural products in one form or another. With the advent and refinement of new technologies, such as genetic techniques for production of secondary plant metabolites, combinatorial synthesis and high-throughput screening, it is expected that novel compounds from natural sources, including medicinal plants, would be identified and developed as safe and effective chemopreventive and anticancer drugs. Numerous bioactive natural compounds have been shown to be useful in prevention and therapy of cancer by targeting various signaling molecules and pathways. Extensive literature underscores the anticancer and chemopreventive activity of a plethora of naturally occurring agents, including phytochemicals. Several of these molecules have been tested in clinical trials and some of them have shown promise in combination therapy when administered along with standard chemotherapeutic agents. Thus, accelerated chemopreventive and chemotherapeutic drug development from natural sources is of great importance. In this special theme issue, contributions from eminent scientists and scholars around the world presented critical analysis of the current progress and promise of natural bioactive constituents in cancer prevention and therapy. Copyright © 2016 Elsevier Ltd. All rights reserved.

The AGORA High-resolution Galaxy Simulations Comparison Project II: Isolated disk test

DOE PAGES

Kim, Ji-hoon; Agertz, Oscar; Teyssier, Romain; ...

2016-12-20

Using an isolated Milky Way-mass galaxy simulation, we compare results from 9 state-of-the-art gravito-hydrodynamics codes widely used in the numerical community. We utilize the infrastructure we have built for the AGORA High-resolution Galaxy Simulations Comparison Project. This includes the common disk initial conditions, common physics models (e.g., radiative cooling and UV background by the standardized package Grackle) and common analysis toolkit yt, all of which are publicly available. Subgrid physics models such as Jeans pressure floor, star formation, supernova feedback energy, and metal production are carefully constrained across code platforms. With numerical accuracy that resolves the disk scale height, wemore » find that the codes overall agree well with one another in many dimensions including: gas and stellar surface densities, rotation curves, velocity dispersions, density and temperature distribution functions, disk vertical heights, stellar clumps, star formation rates, and Kennicutt-Schmidt relations. Quantities such as velocity dispersions are very robust (agreement within a few tens of percent at all radii) while measures like newly-formed stellar clump mass functions show more significant variation (difference by up to a factor of ~3). Systematic differences exist, for example, between mesh-based and particle-based codes in the low density region, and between more diffusive and less diffusive schemes in the high density tail of the density distribution. Yet intrinsic code differences are generally small compared to the variations in numerical implementations of the common subgrid physics such as supernova feedback. Lastly, our experiment reassures that, if adequately designed in accordance with our proposed common parameters, results of a modern high-resolution galaxy formation simulation are more sensitive to input physics than to intrinsic differences in numerical schemes.« less

The AGORA High-resolution Galaxy Simulations Comparison Project II: Isolated disk test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Ji-hoon; Agertz, Oscar; Teyssier, Romain

Using an isolated Milky Way-mass galaxy simulation, we compare results from 9 state-of-the-art gravito-hydrodynamics codes widely used in the numerical community. We utilize the infrastructure we have built for the AGORA High-resolution Galaxy Simulations Comparison Project. This includes the common disk initial conditions, common physics models (e.g., radiative cooling and UV background by the standardized package Grackle) and common analysis toolkit yt, all of which are publicly available. Subgrid physics models such as Jeans pressure floor, star formation, supernova feedback energy, and metal production are carefully constrained across code platforms. With numerical accuracy that resolves the disk scale height, wemore » find that the codes overall agree well with one another in many dimensions including: gas and stellar surface densities, rotation curves, velocity dispersions, density and temperature distribution functions, disk vertical heights, stellar clumps, star formation rates, and Kennicutt-Schmidt relations. Quantities such as velocity dispersions are very robust (agreement within a few tens of percent at all radii) while measures like newly-formed stellar clump mass functions show more significant variation (difference by up to a factor of ~3). Systematic differences exist, for example, between mesh-based and particle-based codes in the low density region, and between more diffusive and less diffusive schemes in the high density tail of the density distribution. Yet intrinsic code differences are generally small compared to the variations in numerical implementations of the common subgrid physics such as supernova feedback. Lastly, our experiment reassures that, if adequately designed in accordance with our proposed common parameters, results of a modern high-resolution galaxy formation simulation are more sensitive to input physics than to intrinsic differences in numerical schemes.« less

THE AGORA HIGH-RESOLUTION GALAXY SIMULATIONS COMPARISON PROJECT. II. ISOLATED DISK TEST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Ji-hoon; Agertz, Oscar; Teyssier, Romain

Using an isolated Milky Way-mass galaxy simulation, we compare results from nine state-of-the-art gravito-hydrodynamics codes widely used in the numerical community. We utilize the infrastructure we have built for the AGORA High-resolution Galaxy Simulations Comparison Project. This includes the common disk initial conditions, common physics models (e.g., radiative cooling and UV background by the standardized package Grackle) and common analysis toolkit yt, all of which are publicly available. Subgrid physics models such as Jeans pressure floor, star formation, supernova feedback energy, and metal production are carefully constrained across code platforms. With numerical accuracy that resolves the disk scale height, wemore » find that the codes overall agree well with one another in many dimensions including: gas and stellar surface densities, rotation curves, velocity dispersions, density and temperature distribution functions, disk vertical heights, stellar clumps, star formation rates, and Kennicutt–Schmidt relations. Quantities such as velocity dispersions are very robust (agreement within a few tens of percent at all radii) while measures like newly formed stellar clump mass functions show more significant variation (difference by up to a factor of ∼3). Systematic differences exist, for example, between mesh-based and particle-based codes in the low-density region, and between more diffusive and less diffusive schemes in the high-density tail of the density distribution. Yet intrinsic code differences are generally small compared to the variations in numerical implementations of the common subgrid physics such as supernova feedback. Our experiment reassures that, if adequately designed in accordance with our proposed common parameters, results of a modern high-resolution galaxy formation simulation are more sensitive to input physics than to intrinsic differences in numerical schemes.« less

Cryogenics and its application with reference to spice grinding: a review.

PubMed

Balasubramanian, S; Gupta, Manoj Kumar; Singh, K K

2012-01-01

Cryogenics is the study of very low temperature and its application on different materials including biological products. Cryogenics has numerous applications in space science, electronics, automobiles, the manufacturing industry, sports and musical instruments, biological science and agriculture, etc. Cryogenic freezing finds pivotal application in food, that is, spices and condiments. Although there is a wide range of cryogens to produce the desired low temperature, generally liquid nitrogen (LN₂) is used in food grinding. The application of low temperature shows a promising pathway to produce higher quality end product with higher flavor and volatile oil retention. Cryogenic grinders generally consist of precoolers and grinder with the cryogen distribution system. In such grinding systems, cryogens subject the raw material up to or lower than glass transition temperature before it is ground, thus eliminating much of the material and quality hassles of traditional grinding. At present, the capital investment including cryogen and handling costs escalate the final cost of the product. Thus, for large-scale production, a proper design to optimize and make it feasible is the need of the hour and understanding the behavior of different food materials at these low temperature conditions. This article reviews the scenario and application of cryogenics in different sectors, especially to spice grinding.

Compendium of NASA data base for the Global Tropospheric Experiment's Arctic Boundary Layer Experiments ABLE-3A and ABLE-3B

NASA Technical Reports Server (NTRS)

Gregory, Gerald L.; Scott, A. Donald, Jr.

1994-01-01

The report provides a compendium of NASA aircraft data that are available from NASA's Global Tropospheric Experiment's (GTE) Arctic Boundary Layer Experiments (ABLE) conducted in July and August of 1988 (ABLE-3A) and 1990 (ABLE-3B). ABLE-3A flight experiments were based at Barrow and Bethel, Alaska, and included survey/transit flights to Thule, Greenland. ABLE-3B flight experiments were based at North Bay (Ontario) and Goose Bay, Canada, and included flights northward to Frobisher Bay, Canada. The primary purposes of the experiments were (1) the measurement of the flux of various trace gases from high-arctic ecosystems, (2) the elucidation of factors important to the production and destruction of ozone, and (3) the documentation of source and chemical signature of air common to and transported into the regions. The report provides a representation, in the form of selected data plots, of aircraft data that are available in archived format via NASA Langley's Distributed Active Archive Center. The archived data bases include data for other species measured on the aircraft as well as numerous supporting data, including meteorological observations/products, results from surface studies, satellite observations, and sondes releases.

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

PubMed Central

Talero, Elena; García-Mauriño, Sofía; Ávila-Román, Javier; Rodríguez-Luna, Azahara; Alcaide, Antonio; Motilva, Virginia

2015-01-01

The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, associated with chronic exposure to ultraviolet light, which can progress to squamous cell carcinoma. Chronic inflammatory states expose these patients to a number of signals with tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release and ROS production. In addition, the participation of inflammasomes, autophagy and sirtuins has been demonstrated in pathological processes such as inflammation and cancer. Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and animal studies have established the potential colon and skin cancer chemopreventive properties of substances from marine environment, including microalgae species and their products (carotenoids, fatty acids, glycolipids, polysaccharides and proteins). This review summarizes the main mechanisms of actions of these compounds in the chemoprevention of these cancers. These actions include suppression of cell proliferation, induction of apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased antioxidant and anti-inflammatory activity. PMID:26437418

Solution of the nonlinear mixed Volterra-Fredholm integral equations by hybrid of block-pulse functions and Bernoulli polynomials.

PubMed

Mashayekhi, S; Razzaghi, M; Tripak, O

2014-01-01

A new numerical method for solving the nonlinear mixed Volterra-Fredholm integral equations is presented. This method is based upon hybrid functions approximation. The properties of hybrid functions consisting of block-pulse functions and Bernoulli polynomials are presented. The operational matrices of integration and product are given. These matrices are then utilized to reduce the nonlinear mixed Volterra-Fredholm integral equations to the solution of algebraic equations. Illustrative examples are included to demonstrate the validity and applicability of the technique.

Simulation of Cascaded Longitudinal-Space-Charge Amplifier at the Fermilab Accelerator Science & Technology (Fast) Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halavanau, A.; Piot, P.

2015-12-01

Cascaded Longitudinal Space Charge Amplifiers (LSCA) have been proposed as a mechanism to generate density modulation over a board spectral range. The scheme has been recently demonstrated in the optical regime and has confirmed the production of broadband optical radiation. In this paper we investigate, via numerical simulations, the performance of a cascaded LSCA beamline at the Fermilab Accelerator Science & Technology (FAST) facility to produce broadband ultraviolet radiation. Our studies are carried out using elegant with included tree-based grid-less space charge algorithm.

Solution of the Nonlinear Mixed Volterra-Fredholm Integral Equations by Hybrid of Block-Pulse Functions and Bernoulli Polynomials

PubMed Central

Mashayekhi, S.; Razzaghi, M.; Tripak, O.

2014-01-01

A new numerical method for solving the nonlinear mixed Volterra-Fredholm integral equations is presented. This method is based upon hybrid functions approximation. The properties of hybrid functions consisting of block-pulse functions and Bernoulli polynomials are presented. The operational matrices of integration and product are given. These matrices are then utilized to reduce the nonlinear mixed Volterra-Fredholm integral equations to the solution of algebraic equations. Illustrative examples are included to demonstrate the validity and applicability of the technique. PMID:24523638

Synthesis and antioxidant activity of curcumin analogs.

PubMed

Zheng, Qu-Tong; Yang, Ze-Hua; Yu, Liu-Ying; Ren, Yu-Yan; Huang, Qiu-Xia; Liu, Qiu; Ma, Xiang-Yu; Chen, Zi-Kang; Wang, Zong-Bao; Zheng, Xing

2017-05-01

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure-activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.

Rapid Production of Mixed-Base Hydrogen Peroxide by Direct-Contact Liquefied Nitrogen Evaporation; Process Design, Scale-Up, and Validation

DTIC Science & Technology

2004-01-01

phase in November 1996. 1-2. BASIC HYDROGEN PEROXIDE In the early COIL work, either potassium hydroxide (KOH) or sodium hydroxide (NaOH) was the base of...the candidate refrigerants include: R22, R404a, R134a, carbon dioxide, and ammonia. 2-3-3. Surface Evaporator To improve the heat transfer efficiency...monohydrate (LiOH.H20), sodium hydroxide (NaOH), and potassium hydroxide (KOH). The use of solids allows numerous variations of blending sequence and heat

A tensor approach to modeling of nonhomogeneous nonlinear systems

NASA Technical Reports Server (NTRS)

Yurkovich, S.; Sain, M.

1980-01-01

Model following control methodology plays a key role in numerous application areas. Cases in point include flight control systems and gas turbine engine control systems. Typical uses of such a design strategy involve the determination of nonlinear models which generate requested control and response trajectories for various commands. Linear multivariable techniques provide trim about these motions; and protection logic is added to secure the hardware from excursions beyond the specification range. This paper reports upon experience in developing a general class of such nonlinear models based upon the idea of the algebraic tensor product.

Manufacturing engineering: Principles for optimization

NASA Astrophysics Data System (ADS)

Koenig, Daniel T.

Various subjects in the area of manufacturing engineering are addressed. The topics considered include: manufacturing engineering organization concepts and management techniques, factory capacity and loading techniques, capital equipment programs, machine tool and equipment selection and implementation, producibility engineering, methods, planning and work management, and process control engineering in job shops. Also discussed are: maintenance engineering, numerical control of machine tools, fundamentals of computer-aided design/computer-aided manufacture, computer-aided process planning and data collection, group technology basis for plant layout, environmental control and safety, and the Integrated Productivity Improvement Program.

Protect Against Exposure on Formaldehyde

EPA Pesticide Factsheets

Formaldehyde is an important chemical used widely by industry to manufacture building materials and numerous household products. It is also a by-product of combustion and certain other natural processes.

WHAT HAPPENS TO FLUOROTELOMER POLYMER PRODUCTS DURING WASTEWATER TREATMENT?

EPA Science Inventory

Fluorotelomer based polymers formulate numerous products relied upon by society. Despite their widespread use and high opportunity for down-the-drain disposal, the fate and stability of fluorotelomer polymer products in wastewater treatment systems remains unknown. To address thi...

The role of physical digit representation and numerical magnitude representation in children's multiplication fact retrieval.

PubMed

De Visscher, Alice; Noël, Marie-Pascale; De Smedt, Bert

2016-12-01

Arithmetic facts, in particular multiplication tables, are thought to be stored in long-term memory and to be interference prone. At least two representations underpinning these arithmetic facts have been suggested: a physical representation of the digits and a numerical magnitude representation. We hypothesized that both representations are possible sources of interference that could explain individual differences in multiplication fact performance and/or in strategy use. We investigated the specificity of these interferences on arithmetic fact retrieval and explored the relation between interference and performance on the different arithmetic operations and on general mathematics achievement. Participants were 79 fourth-grade children (M age =9.6 years) who completed a products comparison and a multiplication production task with verbal strategy reports. Performances on a speeded calculation test including the four operations and on a general mathematics achievement test were also collected. Only the interference coming from physical representations was a significant predictor of the performance across multiplications. However, both the magnitude and physical representations were unique predictors of individual differences in multiplication. The frequency of the retrieval strategy across multiplication problems and across individuals was determined only by the physical representation, which therefore is suggested as being responsible for memory storage issues. Interestingly, this impact of physical representation was not observed when predicting performance on subtraction or on general mathematical achievement. In contrast, the impact of the numerical magnitude representation was more general in that it was observed across all arithmetic operations and in general mathematics achievement. Copyright © 2016 Elsevier Inc. All rights reserved.

Influence of Hydraulic Fracturing on Overlying Aquifers in the Presence of Leaky Abandoned Wells.

PubMed

Brownlow, Joshua W; James, Scott C; Yelderman, Joe C

2016-11-01

The association between hydrocarbon-rich reservoirs and organic-rich source rocks means unconventional oil and gas plays usually occur in mature sedimentary basins-where large-scale conventional development has already taken place. Abandoned wells in proximity to hydraulic fracturing could be affected by increased fluid pressures and corresponding newly generated fractures that directly connect (frac hit) to an abandoned well or to existing fractures intersecting an abandoned well. If contaminants migrate to a pathway hydraulically connected to an abandoned well, upward leakage may occur. Potential effects of hydraulic fracturing on upward flow through a particular type of leaky abandoned well-abandoned oil and gas wells converted into water wells were investigated using numerical modeling. Several factors that affect flow to leaky wells were considered including proximity of a leaky well to hydraulic fracturing, flowback, production, and leaky well abandonment methods. The numerical model used historical records and available industry data for the Eagle Ford Shale play in south Texas. Numerical simulations indicate that upward contaminant migration could occur through leaky converted wells if certain spatial and hydraulic conditions exist. Upward flow through leaky converted wells increased with proximity to hydraulic fracturing, but decreased when flowback and production occurred. Volumetric flow rates ranged between 0 and 0.086 m 3 /d for hydraulic-fracturing scenarios. Potential groundwater impacts should be paired with plausible transport mechanisms, and upward flow through leaky abandoned wells could be unrelated to hydraulic fracturing. The results also underscore the need to evaluate historical activities. © 2016, National Ground Water Association.

BISON Theory Manual The Equations behind Nuclear Fuel Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hales, J. D.; Williamson, R. L.; Novascone, S. R.

2016-09-01

BISON is a finite element-based nuclear fuel performance code applicable to a variety of fuel forms including light water reactor fuel rods, TRISO particle fuel, and metallic rod and plate fuel. It solves the fully-coupled equations of thermomechanics and species diffusion, for either 2D axisymmetric or 3D geometries. Fuel models are included to describe temperature and burnup dependent thermal properties, fission product swelling, densification, thermal and irradiation creep, fracture, and fission gas production and release. Plasticity, irradiation growth, and thermal and irradiation creep models are implemented for clad materials. Models are also available to simulate gap heat transfer, mechanical contact,more » and the evolution of the gap/plenum pressure with plenum volume, gas temperature, and fission gas addition. BISON is based on the MOOSE framework and can therefore efficiently solve problems using standard workstations or very large high-performance computers. This document describes the theoretical and numerical foundations of BISON.« less

Secondary production of massive quarks in thrust

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoang, André H.; Erwin Schrödinger International Institute for Mathematical Physics, University of Vienna, Boltzmanngasse 9, A-1090 Vienna; Mateu, Vicent

2016-01-22

We present a factorization framework that takes into account the production of heavy quarks through gluon splitting in the thrust distribution for e{sup +}e{sup −} → hadrons. The explicit factorization theorems and some numerical results are displayed in the dijet region where the kinematic scales are widely separated, which can be extended systematically to the whole spectrum. We account for the necessary two-loop matrix elements, threshold corrections, and include resummation up to N{sup 3}LL order. We include nonperturbative power corrections through a field theoretical shape function, and remove the O(Λ{sub QCD}) renormalon in the partonic soft function by appropriate mass-dependentmore » subtractions. Our results hold for any value of the quark mass, from an infinitesimally small (merging to the known massless result) to an infinitely large one (achieving the decoupling limit). This is the first example of an application of a variable flavor number scheme to final state jets.« less

MEKS: A program for computation of inclusive jet cross sections at hadron colliders

NASA Astrophysics Data System (ADS)

Gao, Jun; Liang, Zhihua; Soper, Davison E.; Lai, Hung-Liang; Nadolsky, Pavel M.; Yuan, C.-P.

2013-06-01

EKS is a numerical program that predicts differential cross sections for production of single-inclusive hadronic jets and jet pairs at next-to-leading order (NLO) accuracy in a perturbative QCD calculation. We describe MEKS 1.0, an upgraded EKS program with increased numerical precision, suitable for comparisons to the latest experimental data from the Large Hadron Collider and Tevatron. The program integrates the regularized patron-level matrix elements over the kinematical phase space for production of two and three partons using the VEGAS algorithm. It stores the generated weighted events in finely binned two-dimensional histograms for fast offline analysis. A user interface allows one to customize computation of inclusive jet observables. Results of a benchmark comparison of the MEKS program and the commonly used FastNLO program are also documented. Program SummaryProgram title: MEKS 1.0 Catalogue identifier: AEOX_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOX_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland. Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 9234 No. of bytes in distributed program, including test data, etc.: 51997 Distribution format: tar.gz Programming language: Fortran (main program), C (CUBA library and analysis program). Computer: All. Operating system: Any UNIX-like system. RAM: ˜300 MB Classification: 11.1. External routines: LHAPDF (https://lhapdf.hepforge.org/) Nature of problem: Computation of differential cross sections for inclusive production of single hadronic jets and jet pairs at next-to-leading order accuracy in perturbative quantum chromodynamics. Solution method: Upon subtraction of infrared singularities, the hard-scattering matrix elements are integrated over available phase space using an optimized VEGAS algorithm. Weighted events are generated and filled into a finely binned two-dimensional histogram, from which the final cross sections with typical experimental binning and cuts are computed by an independent analysis program. Monte Carlo sampling of event weights is tuned automatically to get better efficiency. Running time: Depends on details of the calculation and sought numerical accuracy. See benchmark performance in Section 4. The tests provided take approximately 27 min for the jetbin run and a few seconds for jetana.

Additive-manufactured sandwich lattice structures: A numerical and experimental investigation

NASA Astrophysics Data System (ADS)

Fergani, Omar; Tronvoll, Sigmund; Brøtan, Vegard; Welo, Torgeir; Sørby, Knut

2017-10-01

The utilization of additive-manufactured lattice structures in engineered products is becoming more and more common as the competitiveness of AM as a production technology has increased during the past several years. Lattice structures may enable important weight reductions as well as open opportunities to build products with customized functional properties, thanks to the flexibility of AM for producing complex geometrical configurations. One of the most critical aspects related to taking AM into new application areas—such as safety critical products—is currently the limited understanding of the mechanical behavior of sandwich-based lattice structure mechanical under static and dynamic loading. In this study, we evaluate manufacturability of lattice structures and the impact of AM processing parameters on the structural behavior of this type of sandwich structures. For this purpose, we conducted static compression testing for a variety of geometry and manufacturing parameters. Further, the study discusses a numerical model capable of predicting the behavior of different lattice structure. A reasonably good correlation between the experimental and numerical results was observed.

Formaldehyde's Impact on Indoor Air Quality

EPA Pesticide Factsheets

Formaldehyde is an important chemical used widely by industry to manufacture building materials and numerous household products. It is also a by-product of combustion and certain other natural processes.

Including Memory Friction in Single- and Two-State Quantum Dynamics Simulations.

PubMed

Brown, Paul A; Messina, Michael

2016-03-03

We present a simple computational algorithm that allows for the inclusion of memory friction in a quantum dynamics simulation of a small, quantum, primary system coupled to many atoms in the surroundings. We show how including a memory friction operator, F̂, in the primary quantum system's Hamiltonian operator builds memory friction into the dynamics of the primary quantum system. We show that, in the harmonic, semi-classical limit, this friction operator causes the classical phase-space centers of a wavepacket to evolve exactly as if it were a classical particle experiencing memory friction. We also show that this friction operator can be used to include memory friction in the quantum dynamics of an anharmonic primary system. We then generalize the algorithm so that it can be used to treat a primary quantum system that is evolving, non-adiabatically on two coupled potential energy surfaces, i.e., a model that can be used to model H atom transfer, for example. We demonstrate this approach's computational ease and flexibility by showing numerical results for both harmonic and anharmonic primary quantum systems in the single surface case. Finally, we present numerical results for a model of non-adiabatic H atom transfer between a reactant and product state that includes memory friction on one or both of the non-adiabatic potential energy surfaces and uncover some interesting dynamical effects of non-memory friction on the H atom transfer process.

Thermal-electric numerical simulation of a surface ion source for the production of radioactive ion beams

NASA Astrophysics Data System (ADS)

Manzolaro, Mattia; Meneghetti, Giovanni; Andrighetto, Alberto

2010-11-01

In a facility for the production of radioactive ion beams (RIBs), the target system and the ion source are the most critical objects. In the context of the Selective Production of Exotic Species (SPES) project, a proton beam directly impinges a Uranium Carbide production target, generating approximately 10 13 fissions per second. The radioactive isotopes produced by the 238U fissions are then directed to the ion source to acquire a charge state. After that, the radioactive ions obtained are transported electrostatically to the subsequent areas of the facility. In this work the surface ion source at present adopted for the SPES project is studied by means of both analytical and numerical thermal-electric models. The theoretical results are compared with temperature and electric potential difference measurements.

Numerical research of the optimal control problem in the semi-Markov inventory model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorshenin, Andrey K.; Belousov, Vasily V.; Shnourkoff, Peter V.

2015-03-10

This paper is devoted to the numerical simulation of stochastic system for inventory management products using controlled semi-Markov process. The results of a special software for the system’s research and finding the optimal control are presented.

Numerical Simulation of Oblique Impacts: Impact Melt and Transient Cavity Size

NASA Technical Reports Server (NTRS)

Artemieva, N. A.; Ivanov, B. A.

2001-01-01

We present 3D hydrocode numerical modeling for oblique impacts (i) to estimate the melt production and (ii) to trace the evolution of the transient cavity shape till the crater collapse. Additional information is contained in the original extended abstract.

How Much Dust Does Enceladus eject?

NASA Astrophysics Data System (ADS)

Kempf, S.; Southworth, B.; Srama, R.; Schmidt, J.; Postberg, F.

2016-12-01

There is an ongoing argument how much dust per second the ice volcanoes on Saturn's ice moon eject. By adjusting their plume model to the dust flux measured by the Cassini dust detector during the close Enceladus flyby in 2005, Schmidt et al. (2008) obtained a total dust production rate in the plumes of about 􏱱5 kg/s. On the other hand, Ingersoll and Ewald (2005) derived a dust production rate of 51 kg/s from the total plume brightness. Knowledge of the production rate is essential for estimating the dust to gas mass ratio, which in turn is an important constraint for finding the plume source mechanism. Here we report on measurements of the plume dust density during the last close Cassini flyby at Enceladus in October 2015. The data match our numerical model for the Enceladus plume. The model is based on a large number of dynamical simulations including gravity and Lorentz force to investigate the earliest phase of the ring particle life span. The evolution of the electrostatic charge carried by the initially uncharged grains is treated self-consistently. Our numerical simulations reproduce all Enceladus data sets obtained by Cassini's Cosmic Dust Analyzer (CDA). Our model calculations together with the new density data constrain the Enceladus dust source rate to < 5 kg/s. Based on our simulation results we are able to draw conclusions about the emission of plume particles along the fractures in the south polar terrain.

Numerical investigations on the lateral angular co-extrusion of aluminium and steel

NASA Astrophysics Data System (ADS)

Behrens, B.-A.; Klose, C.; Chugreev, A.; Thürer, S. E.; Uhe, J.

2018-05-01

In order to save weight and costs, different materials can be combined within one component. In the novel process chain being developed within the Collaborative Research Centre (CRC) 1153, joined semi-finished workpieces are used to produce hybrid solid components with locally adapted properties. Different materials are joined in an initial step before the forming process takes place. Hereby, the quality of the joining zone is improved by means of the thermo-mechanical treatment during the forming and machining processes. The lateral angular co-extrusion (LACE) approach is used to produce semi-finished workpieces because it allows for the production of coaxial semi-finished products consisting of aluminium and steel. In the further process chain, these semi-finished products are processed into hybrid bearing bushings with locally adapted properties by die forging. In the scope of this work, numerical investigations of the co-extrusion of aluminium-steel compounds were carried out using finite element (FE) simulation in order to examine the influence of the process parameters on the co-extrusion process. For this purpose, the relevant material properties of the aluminium alloy EN AW-6082 were determined experimentally and subsequently implemented in the numerical model. The obtained numerical model was used to study the impact of different ram speeds, press ratios and billet temperatures on the resulting extrusion forces and the material flow. The numerical results have been validated using force-time curves obtained from experimental extrusion tests carried out on a 2.5 MN laboratory extrusion press.

SEMTAP (Serpentine End Match TApe program): The Easy Way to Program Your Numerically Controlled Router for the Production of SEM Joints

Treesearch

Ronald E. Coleman

1977-01-01

SEMTAP (Serpentine End Match TApe Program) is an easy and inexpensive method of programing a numerically controlled router for the manufacture of SEM (Serpentine End Matching) joints. The SEMTAP computer program allows the user to issue commands that will accurately direct a numerically controlled router along any SEM path. The user need not be a computer programer to...

Next-to-Leading-Order QCD Corrections to Higgs Boson Plus Jet Production with Full Top-Quark Mass Dependence

NASA Astrophysics Data System (ADS)

Jones, S. P.; Kerner, M.; Luisoni, G.

2018-04-01

We present the next-to-leading-order QCD corrections to the production of a Higgs boson in association with one jet at the LHC including the full top-quark mass dependence. The mass of the bottom quark is neglected. The two-loop integrals appearing in the virtual contribution are calculated numerically using the method of sector decomposition. We study the Higgs boson transverse momentum distribution, focusing on the high pt ,H region, where the top-quark loop is resolved. We find that the next-to-leading-order QCD corrections are large but that the ratio of the next-to-leading-order to leading-order result is similar to that obtained by computing in the limit of large top-quark mass.

How classical gluon fields generate odd azimuthal harmonics for the two-gluon correlation function in high-energy collisions

NASA Astrophysics Data System (ADS)

Kovchegov, Yuri V.; Skokov, Vladimir V.

2018-05-01

We show that, in the saturation/color glass condensate framework, odd azimuthal harmonics of the two-gluon correlation function with a long-range separation in rapidity are generated by the higher-order saturation corrections in the interactions with the projectile and the target. At the very least, the odd harmonics require three scatterings in the projectile and three scatterings in the target. We derive the leading-order expression for the two-gluon production cross section which generates odd harmonics: the expression includes all-order interactions with the target and three interactions with the projectile. We evaluate the obtained expression both analytically and numerically, confirming that the odd-harmonics contribution to the two-gluon production in the saturation framework is nonzero.

Next-to-Leading-Order QCD Corrections to Higgs Boson Plus Jet Production with Full Top-Quark Mass Dependence.

PubMed

Jones, S P; Kerner, M; Luisoni, G

2018-04-20

We present the next-to-leading-order QCD corrections to the production of a Higgs boson in association with one jet at the LHC including the full top-quark mass dependence. The mass of the bottom quark is neglected. The two-loop integrals appearing in the virtual contribution are calculated numerically using the method of sector decomposition. We study the Higgs boson transverse momentum distribution, focusing on the high p_{t,H} region, where the top-quark loop is resolved. We find that the next-to-leading-order QCD corrections are large but that the ratio of the next-to-leading-order to leading-order result is similar to that obtained by computing in the limit of large top-quark mass.

Bioreactors for plant cells: hardware configuration and internal environment optimization as tools for wider commercialization.

PubMed

Georgiev, Milen I; Weber, Jost

2014-07-01

Mass production of value-added molecules (including native and heterologous therapeutic proteins and enzymes) by plant cell culture has been demonstrated as an efficient alternative to classical technologies [i.e. natural harvest and chemical (semi)synthesis]. Numerous proof-of-concept studies have demonstrated the feasibility of scaling up plant cell culture-based processes (most notably to produce paclitaxel) and several commercial processes have been established so far. The choice of a suitable bioreactor design (or modification of an existing commercially available reactor) and the optimization of its internal environment have been proven as powerful tools toward successful mass production of desired molecules. This review highlights recent progress (mostly in the last 5 years) in hardware configuration and optimization of bioreactor culture conditions for suspended plant cells.

Recent Advances in the Discovery and Development of Marine Microbial Natural Products

PubMed Central

Xiong, Zhi-Qiang; Wang, Jian-Feng; Hao, Yu-You; Wang, Yong

2013-01-01

Marine microbial natural products (MMNPs) have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists during the last few decades. Numerous studies have indicated that diverse marine microbes appear to have the capacity to produce an impressive array of MMNPs exhibiting a wide variety of biological activities such as antimicrobial, anti-tumor, anti-inflammatory and anti-cardiovascular agents. Marine microorganisms represent an underexplored reservoir for the discovery of MMNPs with unique scaffolds and for exploitation in the pharmaceutical and agricultural industries. This review focuses on MMNPs discovery and development over the past decades, including innovative isolation and culture methods, strategies for discovering novel MMNPs via routine screenings, metagenomics, genomics, combinatorial biosynthesis, and synthetic biology. The potential problems and future directions for exploring MMNPs are also discussed. PMID:23528949

Recent advances in the discovery and development of marine microbial natural products.

PubMed

Xiong, Zhi-Qiang; Wang, Jian-Feng; Hao, Yu-You; Wang, Yong

2013-03-08

Marine microbial natural products (MMNPs) have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists during the last few decades. Numerous studies have indicated that diverse marine microbes appear to have the capacity to produce an impressive array of MMNPs exhibiting a wide variety of biological activities such as antimicrobial, anti-tumor, anti-inflammatory and anti-cardiovascular agents. Marine microorganisms represent an underexplored reservoir for the discovery of MMNPs with unique scaffolds and for exploitation in the pharmaceutical and agricultural industries. This review focuses on MMNPs discovery and development over the past decades, including innovative isolation and culture methods, strategies for discovering novel MMNPs via routine screenings, metagenomics, genomics, combinatorial biosynthesis, and synthetic biology. The potential problems and future directions for exploring MMNPs are also discussed.

Transform Faults and Lithospheric Structure: Insights from Numerical Models and Shipboard and Geodetic Observations

NASA Astrophysics Data System (ADS)

Takeuchi, Christopher S.

In this dissertation, I study the influence of transform faults on the structure and deformation of the lithosphere, using shipboard and geodetic observations as well as numerical experiments. I use marine topography, gravity, and magnetics to examine the effects of the large age-offset Andrew Bain transform fault on accretionary processes within two adjacent segments of the Southwest Indian Ridge. I infer from morphology, high gravity, and low magnetization that the extremely cold and thick lithosphere associated with the Andrew Bain strongly suppresses melt production and crustal emplacement to the west of the transform fault. These effects are counteracted by enhanced temperature and melt production near the Marion Hotspot, east of the transform fault. I use numerical models to study the development of lithospheric shear zones underneath continental transform faults (e.g. the San Andreas Fault in California), with a particular focus on thermomechanical coupling and shear heating produced by long-term fault slip. I find that these processes may give rise to long-lived localized shear zones, and that such shear zones may in part control the magnitude of stress in the lithosphere. Localized ductile shear participates in both interseismic loading and postseismic relaxation, and predictions of models including shear zones are within observational constraints provided by geodetic and surface heat flow data. I numerically investigate the effects of shear zones on three-dimensional postseismic deformation. I conclude that the presence of a thermally-activated shear zone minimally impacts postseismic deformation, and that thermomechanical coupling alone is unable to generate sufficient localization for postseismic relaxation within a ductile shear zone to kinematically resemble that by aseismic fault creep (afterslip). I find that the current record geodetic observations of postseismic deformation do not provide robust discriminating power between candidate linear and power-law rheologies for the sub-Mojave Desert mantle, but longer observations may potentially allow such discrimination.

The Power of the Spectrum: Combining Numerical Proxy System Models with Analytical Error Spectra to Better Understand Timescale Dependent Proxy Uncertainty

NASA Astrophysics Data System (ADS)

Dolman, A. M.; Laepple, T.; Kunz, T.

2017-12-01

Understanding the uncertainties associated with proxy-based reconstructions of past climate is critical if they are to be used to validate climate models and contribute to a comprehensive understanding of the climate system. Here we present two related and complementary approaches to quantifying proxy uncertainty. The proxy forward model (PFM) "sedproxy" bitbucket.org/ecus/sedproxy numerically simulates the creation, archiving and observation of marine sediment archived proxies such as Mg/Ca in foraminiferal shells and the alkenone unsaturation index UK'37. It includes the effects of bioturbation, bias due to seasonality in the rate of proxy creation, aliasing of the seasonal temperature cycle into lower frequencies, and error due to cleaning, processing and measurement of samples. Numerical PFMs have the advantage of being very flexible, allowing many processes to be modelled and assessed for their importance. However, as more and more proxy-climate data become available, their use in advanced data products necessitates rapid estimates of uncertainties for both the raw reconstructions, and their smoothed/derived products, where individual measurements have been aggregated to coarser time scales or time-slices. To address this, we derive closed-form expressions for power spectral density of the various error sources. The power spectra describe both the magnitude and autocorrelation structure of the error, allowing timescale dependent proxy uncertainty to be estimated from a small number of parameters describing the nature of the proxy, and some simple assumptions about the variance of the true climate signal. We demonstrate and compare both approaches for time-series of the last millennia, Holocene, and the deglaciation. While the numerical forward model can create pseudoproxy records driven by climate model simulations, the analytical model of proxy error allows for a comprehensive exploration of parameter space and mapping of climate signal re-constructability, conditional on the climate and sampling conditions.

Knowledge and tools to enhance resilience of beef grazing systems for sustainable animal protein production.

PubMed

Steiner, Jean L; Engle, David M; Xiao, Xiangming; Saleh, Ali; Tomlinson, Peter; Rice, Charles W; Cole, N Andy; Coleman, Samuel W; Osei, Edward; Basara, Jeffrey; Middendorf, Gerad; Gowda, Prasanna; Todd, Richard; Moffet, Corey; Anandhi, Aavudai; Starks, Patrick J; Ocshner, Tyson; Reuter, Ryan; Devlin, Daniel

2014-11-01

Ruminant livestock provides meat and dairy products that sustain health and livelihood for much of the world's population. Grazing lands that support ruminant livestock provide numerous ecosystem services, including provision of food, water, and genetic resources; climate and water regulation; support of soil formation; nutrient cycling; and cultural services. In the U.S. southern Great Plains, beef production on pastures, rangelands, and hay is a major economic activity. The region's climate is characterized by extremes of heat and cold and extremes of drought and flooding. Grazing lands occupy a large portion of the region's land, significantly affecting carbon, nitrogen, and water budgets. To understand vulnerabilities and enhance resilience of beef production, a multi-institutional Coordinated Agricultural Project (CAP), the "grazing CAP," was established. Integrative research and extension spanning biophysical, socioeconomic, and agricultural disciplines address management effects on productivity and environmental footprints of production systems. Knowledge and tools being developed will allow farmers and ranchers to evaluate risks and increase resilience to dynamic conditions. The knowledge and tools developed will also have relevance to grazing lands in semiarid and subhumid regions of the world. © 2014 New York Academy of Sciences.

Fraser River sockeye salmon productivity and climate: A re-analysis that avoids an undesirable property of Ricker’s curve

NASA Astrophysics Data System (ADS)

McKinnell, Skip

2008-05-01

In descending order of importance, artificial spawning channels, density-dependent mortality, carryover mortality, and climate have significant influences on the average productivity of Fraser River sockeye salmon ( Oncorhynchus nerka). When factors that are known or have been hypothesized to affect Fraser River sockeye salmon productivity are included in a single analytical framework, no significant change in average productivity occurred in 1976/1977, however, beginning in 1989 average productivity was significantly lower. In the one lake (Chilko) in the Fraser River basin where pre-smolt survival can be distinguished from post-smolt survival, this decline arose from freshwater causes. After accounting for other factors that have a greater influence, Fraser River sockeye salmon productivity tends to be slightly lower in years when the intensity of the Aleutian low pressure region is stormier in winter, although the effect is not strongly expressed in any particular population. A footnote to the study was the realization that estimates of Ricker’s density-dependent mortality parameter, β, are influenced by both the numerical properties of the equation and by population biology; density-dependent and density-independent influences on the estimates of the parameter are confounded.

Optimising the production of succinate and lactate in Escherichia coli using a hybrid of artificial bee colony algorithm and minimisation of metabolic adjustment.

PubMed

Tang, Phooi Wah; Choon, Yee Wen; Mohamad, Mohd Saberi; Deris, Safaai; Napis, Suhaimi

2015-03-01

Metabolic engineering is a research field that focuses on the design of models for metabolism, and uses computational procedures to suggest genetic manipulation. It aims to improve the yield of particular chemical or biochemical products. Several traditional metabolic engineering methods are commonly used to increase the production of a desired target, but the products are always far below their theoretical maximums. Using numeral optimisation algorithms to identify gene knockouts may stall at a local minimum in a multivariable function. This paper proposes a hybrid of the artificial bee colony (ABC) algorithm and the minimisation of metabolic adjustment (MOMA) to predict an optimal set of solutions in order to optimise the production rate of succinate and lactate. The dataset used in this work was from the iJO1366 Escherichia coli metabolic network. The experimental results include the production rate, growth rate and a list of knockout genes. From the comparative analysis, ABCMOMA produced better results compared to previous works, showing potential for solving genetic engineering problems. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Off-label use of medicines: The need for good practice guidelines.

PubMed

Dooms, Marc; Killick, James

2017-01-01

'Off-label use' is the term used for the prescription and dispensing of a medicinal product for any indication, patient group, route of administration, dosage or treatment regimen other than that listed in the Summary of Product Characteristics. In this article the authors present a brief overview of current practices of off-label use in Europe and the applicable European law and jurisprudence. They then go on to present a set of guidelines for best practice in off-label use which underlines the need for guidance on prescription to be firmly rooted in the need to ensure patient safety above all other concerns. The article was written from desk research and expert engagement, including a presentation and Q&A in the European Parliament. This article intends to demonstrate that off-label use entails increased risks for patients, especially when it is not underpinned by rigorous clinical studies or the reporting routes for use are not well defined. Europe is seeing a growing trend the promotion of off-label prescription of medicinal products for reasons other than pure medical need, including motives such as cost-containment. This poses a numer of questions for the ethical and legal framework for medicine prescription and dispensing in Europe.

A Chebyshev method for state-to-state reactive scattering using reactant-product decoupling: OH + H2 → H2O + H.

PubMed

Cvitaš, Marko T; Althorpe, Stuart C

2013-08-14

We extend a recently developed wave packet method for computing the state-to-state quantum dynamics of AB + CD → ABC + D reactions [M. T. Cvitaš and S. C. Althorpe, J. Phys. Chem. A 113, 4557 (2009)] to include the Chebyshev propagator. The method uses the further partitioned approach to reactant-product decoupling, which uses artificial decoupling potentials to partition the coordinate space of the reaction into separate reactant, product, and transition-state regions. Separate coordinates and basis sets can then be used that are best adapted to each region. We derive improved Chebyshev partitioning formulas which include Mandelshtam-and-Taylor-type decoupling potentials, and which are essential for the non-unitary discrete variable representations that must be used in 4-atom reactive scattering calculations. Numerical tests on the fully dimensional OH + H2 → H2O + H reaction for J = 0 show that the new version of the method is as efficient as the previously developed split-operator version. The advantages of the Chebyshev propagator (most notably the ease of parallelization for J > 0) can now be fully exploited in state-to-state reactive scattering calculations on 4-atom reactions.

Primordial germ cell-mediated transgenesis and genome editing in birds.

PubMed

Han, Jae Yong; Park, Young Hyun

2018-01-01

Transgenesis and genome editing in birds are based on a unique germline transmission system using primordial germ cells (PGCs), which is quite different from the mammalian transgenic and genome editing system. PGCs are progenitor cells of gametes that can deliver genetic information to the next generation. Since avian PGCs were first discovered in nineteenth century, there have been numerous efforts to reveal their origin, specification, and unique migration pattern, and to improve germline transmission efficiency. Recent advances in the isolation and in vitro culture of avian PGCs with genetic manipulation and genome editing tools enable the development of valuable avian models that were unavailable before. However, many challenges remain in the production of transgenic and genome-edited birds, including the precise control of germline transmission, introduction of exogenous genes, and genome editing in PGCs. Therefore, establishing reliable germline-competent PGCs and applying precise genome editing systems are critical current issues in the production of avian models. Here, we introduce a historical overview of avian PGCs and their application, including improved techniques and methodologies in the production of transgenic and genome-edited birds, and we discuss the future potential applications of transgenic and genome-edited birds to provide opportunities and benefits for humans.

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

PubMed Central

Liu, Gang; Chandra, Govind; Niu, Guoqing

2013-01-01

SUMMARY Streptomycetes are the most abundant source of antibiotics. Typically, each species produces several antibiotics, with the profile being species specific. Streptomyces coelicolor, the model species, produces at least five different antibiotics. We review the regulation of antibiotic biosynthesis in S. coelicolor and other, nonmodel streptomycetes in the light of recent studies. The biosynthesis of each antibiotic is specified by a large gene cluster, usually including regulatory genes (cluster-situated regulators [CSRs]). These are the main point of connection with a plethora of generally conserved regulatory systems that monitor the organism's physiology, developmental state, population density, and environment to determine the onset and level of production of each antibiotic. Some CSRs may also be sensitive to the levels of different kinds of ligands, including products of the pathway itself, products of other antibiotic pathways in the same organism, and specialized regulatory small molecules such as gamma-butyrolactones. These interactions can result in self-reinforcing feed-forward circuitry and complex cross talk between pathways. The physiological signals and regulatory mechanisms may be of practical importance for the activation of the many cryptic secondary metabolic gene cluster pathways revealed by recent sequencing of numerous Streptomyces genomes. PMID:23471619

The Space Sector and Civilization of Intangible Assets

NASA Astrophysics Data System (ADS)

Hernandez, Daniel

The value of a company is no longer solely measured according to the value of its assets (stock of raw materials, products being manufactured or finished products, machines and tools, real estate, etc.). Intangible assets are also becoming increasingly important, especially in Western economies which have massively transferred the production of goods to the so-called emerging countries offering lower labor costs. Numerous companies subcontracting their production focus on the study and design of new products and their marketing. As a result, the intangible assets (patents, brands, distribution networks, etc.) represent a growing proportion of the value of companies. Nevertheless, it is not impossible, as we saw several decades ago with Japan, for example, that the "emerging" countries which largely depend on contract production and copies, move more or less quickly to economies including the entire chain from design to production of original products. We will analyze here the importance of intangible assets in the space sector, especially as regards orbital systems (satellites and associated ground facilities). While the space sector remains dominated by states through the orders they generate and the regulations they impose on the space industry, the commercial market continues to develop and, with it, the importance of marketing actions and more generally the development of distinctive brands.

Study on the influence of ground and satellite observations on the numerical air-quality for PM10 over Romanian territory

NASA Astrophysics Data System (ADS)

Dumitrache, Rodica Claudia; Iriza, Amalia; Maco, Bogdan Alexandru; Barbu, Cosmin Danut; Hirtl, Marcus; Mantovani, Simone; Nicola, Oana; Irimescu, Anisoara; Craciunescu, Vasile; Ristea, Alina; Diamandi, Andrei

2016-10-01

The numerical forecast of particulate matter concentrations in general, and PM10 in particular is a theme of high socio-economic relevance. The aim of this study was to investigate the impact of ground and satellite data assimilation of PM10 observations into the Weather Research and Forecasting model coupled with Chemistry (WRF-CHEM) numerical air quality model for Romanian territory. This is the first initiative of the kind for this domain of interest. Assimilation of satellite information - e.g. AOT's in air quality models is of interest due to the vast spatial coverage of the observations. Support Vector Regression (SVR) techniques are used to estimate the PM content from heterogeneous data sources, including EO products (Aerosol Optical Thickness), ground measurements and numerical model data (temperature, humidity, wind, etc.). In this study we describe the modeling framework employed and present the evaluation of the impact from the data assimilation of PM10 observations on the forecast of the WRF-CHEM model. Integrations of the WRF-CHEM model in data assimilation enabled/disabled configurations allowed the evaluation of satellite and ground data assimilation impact on the PM10 forecast performance for the Romanian territory. The model integration and evaluation were performed for two months, one in winter conditions (January 2013) and one in summer conditions (June 2013).

Parallel language constructs for tensor product computations on loosely coupled architectures

NASA Technical Reports Server (NTRS)

Mehrotra, Piyush; Vanrosendale, John

1989-01-01

Distributed memory architectures offer high levels of performance and flexibility, but have proven awkard to program. Current languages for nonshared memory architectures provide a relatively low level programming environment, and are poorly suited to modular programming, and to the construction of libraries. A set of language primitives designed to allow the specification of parallel numerical algorithms at a higher level is described. Tensor product array computations are focused on along with a simple but important class of numerical algorithms. The problem of programming 1-D kernal routines is focused on first, such as parallel tridiagonal solvers, and then how such parallel kernels can be combined to form parallel tensor product algorithms is examined.

Numerical studies of depressurization-induced gas production from an interbedded marine turbidite gas hydrate reservoir model

USGS Publications Warehouse

Myshakin, Evgeniy; Lin, Jeen-Shang; Uchida, Shun; Seol, Yongkoo; Collett, Timothy S.; Boswell, Ray

2017-01-01

The numerical simulation of thin hydrate-bearing sand layers interbedded with mud layers is investigated. In this model, the lowest hydrate layer occurs at the base of gas hydrate stability and overlies a thinly-interbedded saline aquifer. The predicted gas rates reach 6.25 MMscf/day (1.77 x 105 m3 /day) after 90 days of continuous depressurization with manageable water production. Development of horizontal dissociating interfaces between hydrate-bearing sand and mud layers is a primary determinant of reservoir performance. A set of simulations has been executed to assess uncertainty in in situ permeability and to determine the impact of the saline aquifer on productivity.

Progress report on LBL's numerical modeling studies on Cerro Prieto

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halfman-Dooley, S.E.; Lippman, M.J.; Bodvarsson, G.S.

1989-04-01

An exploitation model of the Cerro Prieto geothermal system is needed to assess the energy capacity of the field, estimate its productive lifetime and develop an optimal reservoir management plan. The model must consider the natural state (i.e., pre-exploitation) conditions of the system and be able to predict changes in the reservoir thermodynamic conditions (and fluid chemistry) in response to fluid production (and injection). This paper discusses the results of a three-dimensional numerical simulation of the natural state conditions of the Cerro Prieto field and compares computed and observed pressure and temperature/enthalpy changes for the 1973--1987 production period. 16 refs.,more » 24 figs., 2 tabs.« less

Numerical and behavioral effects within a pulse-driven system: consequences for shared prey.

PubMed

Schmidt, Kenneth A; Ostfeld, Richard S

2008-03-01

Some of the clearest examples of the ramifying effects of resource pulses exist in deciduous forests dominated by mast-producing trees, such as oaks, beech, and hornbeam. Seed production in these forests represents only the first of several pulsed events. Secondary pulses emerge as mast-consuming small rodents numerically respond to seed production and tertiary pulses emerge as generalist predators numerically respond to rodents. Raptors may also respond behaviorally (i.e., diet shifts) to subsequent crashes in small rodents following the crash phase in seed production. In oak-dominated forest in the Hudson Valley, New York, these various pulse and crash phases act synergistically, although not simultaneously, to influence thrush population dynamics through predation on nests, juveniles, and adults. As a consequence, factors limiting population growth rate and their age-specific action vary as a function of past acorn production. We highlight these interactions based on our eight-year study of thrush demography, acorn production, and small mammal abundance coupled with information on regional adult thrush population trends from the Breeding Bird Survey. We use these data sets to demonstrate the sequence of primary to tertiary pulses and how they influence breeding thrush populations. To extend our discussion beyond masting phenomena in the eastern United States, we briefly review the literature of alternative avian prey within pulsed systems to show (1) numerical and behavioral responses by generalist predators are ubiquitous in pulsed systems, and this contributes to (2) variability in reproduction and survivorship of avian prey linked to the underlying dynamics of the pulse. We conclude by exploring the broad consequences of cascading resource pulses for alternative prey based upon the indirect interaction of apparent competition among shared prey and the nature of temporal variability on populations.

Numerical simulation of multi-rifled tube drawing - finding proper feedstock dimensions and tool geometry

NASA Astrophysics Data System (ADS)

Bella, P.; Buček, P.; Ridzoň, M.; Mojžiš, M.; Parilák, L.'

2017-02-01

Production of multi-rifled seamless steel tubes is quite a new technology in Železiarne Podbrezová. Therefore, a lot of technological questions emerges (process technology, input feedstock dimensions, material flow during drawing, etc.) Pilot experiments to fine tune the process cost a lot of time and energy. For this, numerical simulation would be an alternative solution for achieving optimal parameters in production technology. This would reduce the number of experiments needed, lowering the overall costs of development. However, to claim the numerical results to be relevant it is necessary to verify them against the actual plant trials. Searching for optimal input feedstock dimension for drawing of multi-rifled tube with dimensions Ø28.6 mm × 6.3 mm is what makes the main topic of this paper. As a secondary task, effective position of the plug - die couple has been solved via numerical simulation. Comparing the calculated results with actual numbers from plant trials a good agreement was observed.

Natural fiber production, harvesting, and preliminary processing: options and opportunities

USDA-ARS?s Scientific Manuscript database

The utilization of natural fibers and plant oils in bio-products introduces numerous logistical challenges not typically encountered with non-agricultural resources. Once it has been determined that a plant material is suitable for commercial development, the production, harvesting, and processing s...

Seed Production in Southern Appalachian Oak Stands

Treesearch

Donald E. Beck; David F. Olson

1968-01-01

Acorn production in mixed oak stands of different densities varied considerably among stands, years, and species. Density had no effect on total acorn production. Although numerous acorns were initiated each year, the majority either failed to develop fully or were damaged by insects and animals.

Site-level evaluation of satellite-based global terrestrial gross primary production and net primary production monitoring.

Treesearch

David P. Turner; William D. Ritts; Warren B. Cohen; Thomas K. Maeirsperger; Stith T. Gower; Al A. Kirschbaum; Steve W. Runnings; Maosheng Zhaos; Steven C. Wofsy; Allison L. Dunn; Beverly E. Law; John L. Campbell; Walter C. Oechel; Hyo Jung Kwon; Tilden P. Meyers; Eric E. Small; Shirley A. Kurc; John A. Gamon

2005-01-01

Operational monitoring of global terrestrial gross primary production (GPP) and net primary production (NPP) is now underway using imagery from the satellite-borne Moderate Resolution Imaging Spectroradiometer (MODIS) sensor. Evaluation of MODIS GPP and NPP products will require site-level studies across a range of biomes, with close attention to numerous scaling...

Biological potential of microalgae in China for biorefinery-based production of biofuels and high value compounds.

PubMed

Li, Jingjing; Liu, Ying; Cheng, Jay J; Mos, Michal; Daroch, Maurycy

2015-12-25

Microalgae abundance and diversity in China shows promise for identifying suitable strains for developing algal biorefinery. Numerous strains of microalgae have already been assessed as feedstocks for bioethanol and biodiesel production, but commercial scale algal biofuel production is yet to be demonstrated, most likely due to huge energy costs associated with algae cultivation, harvesting and processing. Biorefining, integrated processes for the conversion of biomass into a variety of products, can improve the prospects of microalgal biofuels by combining them with the production of high value co-products. Numerous microalgal strains in China have been identified as producers of various high value by-products with wide application in the medicine, food, and cosmetics industries. This paper reviews microalgae resources in China and their potential in producing liquid biofuels (bioethanol and biodiesel) and high value products in an integrated biorefinery approach. Implementation of a 'high value product first' principle should make the integrated process of fuels and chemicals production economically feasible and will ensure that public and private interest in the development of microalgal biotechnology is maintained. Copyright © 2015 Elsevier B.V. All rights reserved.

Restricted numerical range: A versatile tool in the theory of quantum information

NASA Astrophysics Data System (ADS)

Gawron, Piotr; Puchała, Zbigniew; Miszczak, Jarosław Adam; Skowronek, Łukasz; Życzkowski, Karol

2010-10-01

Numerical range of a Hermitian operator X is defined as the set of all possible expectation values of this observable among a normalized quantum state. We analyze a modification of this definition in which the expectation value is taken among a certain subset of the set of all quantum states. One considers, for instance, the set of real states, the set of product states, separable states, or the set of maximally entangled states. We show exemplary applications of these algebraic tools in the theory of quantum information: analysis of k-positive maps and entanglement witnesses, as well as study of the minimal output entropy of a quantum channel. Product numerical range of a unitary operator is used to solve the problem of local distinguishability of a family of two unitary gates.

Computer Training for Entrepreneurial Meteorologists.

NASA Astrophysics Data System (ADS)

Koval, Joseph P.; Young, George S.

2001-05-01

Computer applications of increasing diversity form a growing part of the undergraduate education of meteorologists in the early twenty-first century. The advent of the Internet economy, as well as a waning demand for traditional forecasters brought about by better numerical models and statistical forecasting techniques has greatly increased the need for operational and commercial meteorologists to acquire computer skills beyond the traditional techniques of numerical analysis and applied statistics. Specifically, students with the skills to develop data distribution products are in high demand in the private sector job market. Meeting these demands requires greater breadth, depth, and efficiency in computer instruction. The authors suggest that computer instruction for undergraduate meteorologists should include three key elements: a data distribution focus, emphasis on the techniques required to learn computer programming on an as-needed basis, and a project orientation to promote management skills and support student morale. In an exploration of this approach, the authors have reinvented the Applications of Computers to Meteorology course in the Department of Meteorology at The Pennsylvania State University to teach computer programming within the framework of an Internet product development cycle. Because the computer skills required for data distribution programming change rapidly, specific languages are valuable for only a limited time. A key goal of this course was therefore to help students learn how to retrain efficiently as technologies evolve. The crux of the course was a semester-long project during which students developed an Internet data distribution product. As project management skills are also important in the job market, the course teamed students in groups of four for this product development project. The success, failures, and lessons learned from this experiment are discussed and conclusions drawn concerning undergraduate instructional methods for computer applications in meteorology.

Evaluation of numerical weather predictions performed in the context of the project DAPHNE

NASA Astrophysics Data System (ADS)

Tegoulias, Ioannis; Pytharoulis, Ioannis; Bampzelis, Dimitris; Karacostas, Theodore

2014-05-01

The region of Thessaly in central Greece is one of the main areas of agricultural production in Greece. Severe weather phenomena affect the agricultural production in this region with adverse effects for farmers and the national economy. For this reason the project DAPHNE aims at tackling the problem of drought by means of weather modification through the development of the necessary tools to support the application of a rainfall enhancement program. In the present study the numerical weather prediction system WRF-ARW is used, in order to assess its ability to represent extreme weather phenomena in the region of Thessaly. WRF is integrated in three domains covering Europe, Eastern Mediterranean and Central-Northern Greece (Thessaly and a large part of Macedonia) using telescoping nesting with grid spacing of 15km, 5km and 1.667km, respectively. The cases examined span throughout the transitional and warm period (April to September) of the years 2008 to 2013, including days with thunderstorm activity. Model results are evaluated against all available surface observations and radar products, taking into account the spatial characteristics and intensity of the storms. Preliminary results indicate a good level of agreement between the simulated and observed fields as far as the standard parameters (such as temperature, humidity and precipitation) are concerned. Moreover, the model generally exhibits a potential to represent the occurrence of the convective activity, but not its exact spatiotemporal characteristics. Acknowledgements This research work has been co-financed by the European Union (European Regional Development Fund) and Greek national funds, through the action "COOPERATION 2011: Partnerships of Production and Research Institutions in Focused Research and Technology Sectors" (contract number 11SYN_8_1088 - DAPHNE) in the framework of the operational programme "Competitiveness and Entrepreneurship" and Regions in Transition (OPC II, NSRF 2007-2013)

How much dust does Enceladus eject?

NASA Astrophysics Data System (ADS)

Kempf, Sascha; Horanyi, Mihaly; Schmidt, Jürgen; Southworth, Ben

2015-04-01

There is an ongoing argument how much dust per second the ice volcanoes on Saturn's ice moon Enceladus eject. By adjusting their plume model to the dust flux measured by the Cassini dust detector during the close Enceladus flyby in 2005, as well as to the plume brightness in Cassini imaging, Schmidt et al. (2008) obtained a total dust production rate in the plumes of about 5 kg/s. On the other hand, Ingersoll and Ewald (2011) derived a dust production rate of 51 kg/s from photometry of very high phase-angle images of the plume, a method that is sensitive also to particles in the size range of microns and larger. Knowledge of the production rate is essential for estimating the dust to gas mass ratio, which in turn is an important constraint for finding the plume source mechanism. Here we report on numerical simulations of the Enceladus dust plume. We run a large number of dynamical simulations including gravity and Lorentz force to investigate the earliest phase of the ring particle life span. The magnetic field in the vicinity of Enceladus is based on the model by Simon et al. (2012). The evolution of the electrostatic charge carried by the initially uncharged grains is treated self-consistently. Our numerical simulations reproduce dust measurements by the Cassini Cosmic Dust Analyzer (CDA) during Cassini plume traversals as well as the snowfall pattern derived from ISS observations of the Enceladus surface (Schenk et al, 2011, EPSC abstract). Based on our simulation results we are able to draw conclusions about the dust production rate as well as wether the Enceladus dust plume constitutes a dusty plasma.

Working Group 1 "Advanced GNSS Processing Techniques" of the COST Action GNSS4SWEC: Overview of main achievements

NASA Astrophysics Data System (ADS)

Douša, Jan; Dick, Galina; Kačmařík, Michal; Václavovic, Pavel; Pottiaux, Eric; Zus, Florian; Brenot, Hugues; Moeller, Gregor; Hinterberger, Fabian; Pacione, Rosa; Stuerze, Andrea; Eben, Kryštof; Teferle, Norman; Ding, Wenwu; Morel, Laurent; Kaplon, Jan; Hordyniec, Pavel; Rohm, Witold

2017-04-01

The COST Action ES1206 GNSS4SWEC addresses new exploitations of the synergy between developments in GNSS and meteorological communities. The Working Group 1 (Advanced GNSS processing techniques) deals with implementing and assessing new methods for GNSS tropospheric monitoring and precise positioning exploiting all modern GNSS constellations, signals, products etc. Besides other goals, WG1 coordinates development of advanced tropospheric products in support of weather numerical and non-numerical nowcasting. These are ultra-fast and high-resolution tropospheric products available in real time or in a sub-hourly fashion and parameters in support of monitoring an anisotropy of the troposphere, e.g. horizontal gradients and tropospheric slant path delays. This talk gives an overview of WG1 activities and, particularly, achievements in two activities, Benchmark and Real-time demonstration campaigns. For the Benchmark campaign a complex data set of GNSS observations and various meteorological data were collected for a two-month period in 2013 (May-June) which included severe weather events in central Europe. An initial processing of data sets from GNSS and numerical weather models (NWM) provided independently estimated reference parameters - ZTDs and tropospheric horizontal gradients. The comparison of horizontal tropospheric gradients from GNSS and NWM data demonstrated a very good agreement among independent solutions with negligible biases and an accuracy of about 0.5 mm. Visual comparisons of maps of zenith wet delays and tropospheric horizontal gradients showed very promising results for future exploitations of advanced GNSS tropospheric products in meteorological applications such as severe weather event monitoring and weather nowcasting. The Benchmark data set is also used for an extensive validation of line-of-sight tropospheric Slant Total Delays (STD) from GNSS, NWM-raytracing and Water Vapour Radiometer (WVR) solutions. Seven institutions delivered their STDs estimated based on GNSS observations processed using different software and strategies. STDs from NWM ray-tracing came from three institutions using four different NWM models. Results show generally a very good mutual agreement among all solutions from all techniques. The influence of adding not cleaned GNSS post-fit residuals, i.e. residuals that still contains non-tropospheric systematic effects such as multipath, to estimated STDs will be presented. The Real-time demonstration campaign aims at enhancing and assessing ultra-fast GNSS tropospheric products for severe weather and NWM nowcasting. Results are showed from real-time demonstrations as well as offline production simulating real-time using Benchmark campaign.

What do consumers want?

PubMed

Apple, W

1992-01-01

A consumers' advocate discusses the needs of the consumer in evaluating dental products. Although commending the roles of the FDA and ADA in evaluating products, numerous questions are raised and recommendations made concerning advertising claims.

TRIPOLI-4® - MCNP5 ITER A-lite neutronic model benchmarking

NASA Astrophysics Data System (ADS)

Jaboulay, J.-C.; Cayla, P.-Y.; Fausser, C.; Lee, Y.-K.; Trama, J.-C.; Li-Puma, A.

2014-06-01

The aim of this paper is to present the capability of TRIPOLI-4®, the CEA Monte Carlo code, to model a large-scale fusion reactor with complex neutron source and geometry. In the past, numerous benchmarks were conducted for TRIPOLI-4® assessment on fusion applications. Experiments (KANT, OKTAVIAN, FNG) analysis and numerical benchmarks (between TRIPOLI-4® and MCNP5) on the HCLL DEMO2007 and ITER models were carried out successively. In this previous ITER benchmark, nevertheless, only the neutron wall loading was analyzed, its main purpose was to present MCAM (the FDS Team CAD import tool) extension for TRIPOLI-4®. Starting from this work a more extended benchmark has been performed about the estimation of neutron flux, nuclear heating in the shielding blankets and tritium production rate in the European TBMs (HCLL and HCPB) and it is presented in this paper. The methodology to build the TRIPOLI-4® A-lite model is based on MCAM and the MCNP A-lite model (version 4.1). Simplified TBMs (from KIT) have been integrated in the equatorial-port. Comparisons of neutron wall loading, flux, nuclear heating and tritium production rate show a good agreement between the two codes. Discrepancies are mainly included in the Monte Carlo codes statistical error.

Remote Sensing Applications to Water Quality Management in Florida

NASA Astrophysics Data System (ADS)

Lehrter, J. C.; Schaeffer, B. A.; Hagy, J.; Spiering, B.; Barnes, B.; Hu, C.; Le, C.; McEachron, L.; Underwood, L. W.; Ellis, C.; Fisher, B.

2013-12-01

Optical datasets from estuarine and coastal systems are increasingly available for remote sensing algorithm development, validation, and application. With validated algorithms, the data streams from satellite sensors can provide unprecedented spatial and temporal data for local and regional coastal water quality management. Our presentation will highlight two recent applications of optical data and remote sensing to water quality decision-making in coastal regions of the state of Florida; (1) informing the development of estuarine and coastal nutrient criteria for the state of Florida and (2) informing the rezoning of the Florida Keys National Marine Sanctuary. These efforts involved building up the underlying science to demonstrate the applicability of satellite data as well as an outreach component to educate decision-makers about the use, utility, and uncertainties of remote sensing data products. Scientific developments included testing existing algorithms and generating new algorithms for water clarity and chlorophylla in case II (CDOM or turbidity dominated) estuarine and coastal waters and demonstrating the accuracy of remote sensing data products in comparison to traditional field based measurements. Including members from decision-making organizations on the research team and interacting with decision-makers early and often in the process were key factors for the success of the outreach efforts and the eventual adoption of satellite data into the data records and analyses used in decision-making. Florida coastal water bodies (black boxes) for which remote sensing imagery were applied to derive numeric nutrient criteria and in situ observations (black dots) used to validate imagery. Florida ocean color applied to development of numeric nutrient criteria

AmeriFlux Site and Data Exploration System

NASA Astrophysics Data System (ADS)

Krassovski, M.; Boden, T.; Yang, B.; Jackson, B.

2011-12-01

The AmeriFlux network was established in 1996. The network provides continuous observations of ecosystem-level exchanges of CO2, water, energy and momentum spanning diurnal, synoptic, seasonal, and interannual time scales. The current network, including both active and inactive sites, consists of 141 sites in North, Central, and South America. The Carbon Dioxide Information Analysis Center (CDIAC) at Oak Ridge National Laboratory (ORNL) provides data management support for the AmeriFlux network including long-term data storage and dissemination. AmeriFlux offers a broad suite of value-added data products: Level 1 data products at 30 minute or hourly time intervals provided by the site teams, Level 2 data processed by CDIAC and Level 3 and 4 files created using CarboEurope algorithms. CDIAC has developed a relational database to house the vast array of AmeriFlux data and information and a web-based interface to the database, the AmeriFlux Site and Data Exploration System (http://ameriflux.ornl.gov), to help users worldwide identify, and more recently, download desired AmeriFlux data. AmeriFlux and CDIAC offer numerous value-added AmeriFlux data products (i.e., Level 1-4 data products, biological data) and most of these data products are or will be available through the new data system. Vital site information (e.g., location coordinates, dominant species, land-use history) is also displayed in the new system. The data system provides numerous ways to explore and extract data. Searches can be done by site, location, measurement status, available data products, vegetation types, and by reported measurements just to name a few. Data can be accessed through the links to full data sets reported by a site, organized by types of data products, or by creating customized datasets based on user search criteria. The new AmeriFlux download module contains features intended to ease compliance of the AmeriFlux fair-use data policy, acknowledge the contributions of submitting investigators, inform AmeriFlux investigators of users of their data, and facilitate meaningful usage statistics. Comprehensive site descriptions are available via the same interface along with site-related publications and data visualization functionality. This presentation reflects the present state and functionality of the AmeriFlux Site and Data Exploration System as well as future plans for expansion. For example, future plans call for expansion of the relational database to house similar data from large-scale ecosystem experiments (e.g., FACE, NGEE - Next Generation Ecosystem Experiment) and inclusion of enhanced query capabilities (e.g., sorting data via day and night).

Cross-Section Parameterizations for Pion and Nucleon Production From Negative Pion-Proton Collisions

NASA Technical Reports Server (NTRS)

Norbury, John W.; Blattnig, Steve R.; Norman, Ryan; Tripathi, R. K.

2002-01-01

Ranft has provided parameterizations of Lorentz invariant differential cross sections for pion and nucleon production in pion-proton collisions that are compared to some recent data. The Ranft parameterizations are then numerically integrated to form spectral and total cross sections. These numerical integrations are further parameterized to provide formula for spectral and total cross sections suitable for use in radiation transport codes. The reactions analyzed are for charged pions in the initial state and both charged and neutral pions in the final state.

Assessing concentration uncertainty estimates from passive microwave sea ice products

NASA Astrophysics Data System (ADS)

Meier, W.; Brucker, L.; Miller, J. A.

2017-12-01

Sea ice concentration is an essential climate variable and passive microwave derived estimates of concentration are one of the longest satellite-derived climate records. However, until recently uncertainty estimates were not provided. Numerous validation studies provided insight into general error characteristics, but the studies have found that concentration error varied greatly depending on sea ice conditions. Thus, an uncertainty estimate from each observation is desired, particularly for initialization, assimilation, and validation of models. Here we investigate three sea ice products that include an uncertainty for each concentration estimate: the NASA Team 2 algorithm product, the EUMETSAT Ocean and Sea Ice Satellite Application Facility (OSI-SAF) product, and the NOAA/NSIDC Climate Data Record (CDR) product. Each product estimates uncertainty with a completely different approach. The NASA Team 2 product derives uncertainty internally from the algorithm method itself. The OSI-SAF uses atmospheric reanalysis fields and a radiative transfer model. The CDR uses spatial variability from two algorithms. Each approach has merits and limitations. Here we evaluate the uncertainty estimates by comparing the passive microwave concentration products with fields derived from the NOAA VIIRS sensor. The results show that the relationship between the product uncertainty estimates and the concentration error (relative to VIIRS) is complex. This may be due to the sea ice conditions, the uncertainty methods, as well as the spatial and temporal variability of the passive microwave and VIIRS products.

Assistive technology products: a position paper from the first global research, innovation, and education on assistive technology (GREAT) summit.

PubMed

Smith, Roger O; Scherer, Marcia; Cooper, Rory; Bell, Diane; Hobbs, David A; Pettersson, Cecilia; Seymour, Nicky; Borg, Johan; Johnson, Michelle J; Lane, Joseph P; Srinivasan, S Sujatha; Rao, Pvm; Obiedat, Qussai M; MacLachlan, Mac; Bauer, Stephen

2018-06-06

This paper is based on work from the Global Research, Innovation, and Education on Assistive Technology (GREAT) Summit that was coordinated by WHO's Global Cooperation on Assistive Technology (GATE). The purpose of this paper is to describe the needs and opportunities embedded in the assistive product lifecycle as well as issues relating to the various stages of assistive product mobilization worldwide. The paper discusses assistive technology product terminology and the dangers of focusing on products outside the context and rolling out products without a plan. Additionally, the paper reviews concepts and issues around technology transfer, particularly in relation to meeting global needs and among countries with limited resources. Several opportunities are highlighted including technology advancement and the world nearing a state of readiness through a developing capacity of nations across the world to successfully adopt and support the assistive technology products and applications. The paper is optimistic about the future of assistive technology products reaching the people that can use it the most and the excitement across large and small nations in increasing their own capacities for implementing assistive technology. This is expressed as hope in future students as they innovate and in modern engineering that will enable assistive technology to pervade all corners of current and potential marketplaces. Importantly, the paper poses numerous topics where discussions are just superficially opened. The hope is that a set of sequels will follow to continue this critical dialog. Implications for Rehabilitation Successful assistive technology product interventions are complex and include much more than the simple selection of the right product. Assistive technology product use is highly context sensitive in terms of an individual user's environment. The development of assistive technology products is tricky as it must be contextually sensitive to the development environment and market as well. As a field we have much to study and develop around assistive technology product interventions from a global perspective.

An Approach to Developing Numeric Water Quality Criteria for Using the SeaWiFS Satellite Data Record

EPA Science Inventory

Human activities on land increase nutrient loads to coastal waters, which can increase phytoplankton production and biomass and associated ecological impacts. Numeric nutrient water quality standards were needed to protect coastal waters from eutrophication impacts. The Environm...

A streamlined method for transposon mutagenesis of Rickettsia parkeri yields numerous mutations that impact infection.

PubMed

Lamason, Rebecca L; Kafai, Natasha M; Welch, Matthew D

2018-01-01

The rickettsiae are obligate intracellular alphaproteobacteria that exhibit a complex infectious life cycle in both arthropod and mammalian hosts. As obligate intracellular bacteria, rickettsiae are highly adapted to living inside a variety of host cells, including vascular endothelial cells during mammalian infection. Although it is assumed that the rickettsiae produce numerous virulence factors that usurp or disrupt various host cell pathways, they have been challenging to genetically manipulate to identify the key bacterial factors that contribute to infection. Motivated to overcome this challenge, we sought to expand the repertoire of available rickettsial loss-of-function mutants, using an improved mariner-based transposon mutagenesis scheme. Here, we present the isolation of over 100 transposon mutants in the spotted fever group species Rickettsia parkeri. Transposon insertions disrupted genes whose products are implicated in a variety of pathways, including bacterial replication and metabolism, the type IV secretion system, factors with previously established roles in host cell interactions and pathogenesis, or are of unknown function. Given the need to identify critical virulence factors, forward genetic screens such as this will provide an excellent platform to more directly investigate rickettsial biology and pathogenesis.

Suture Products and Techniques: What to Use, Where, and Why.

PubMed

Regula, Christie G; Yag-Howard, Cyndi

2015-10-01

There are an increasing number of wound closure materials and suturing techniques described in the dermatologic and surgery literature. A dermatologic surgeon's familiarity with these materials and techniques is important to supplement his or her already established practices and improve surgical outcomes. To perform a thorough literature review of wound closure materials (sutures, tissue adhesives, surgical tape, and staples) and suturing techniques and to outline how and when to use them. A literature review was conducted using PubMed and other online search engines. Keywords searched included suture, tissue adhesive, tissue glue, surgical tape, staples, dermatologic suturing, and suturing techniques. Numerous articles outline the utility of various sutures, surgical adhesives, surgical tape, and staples in dermatologic surgery. In addition, there are various articles describing classic and novel suturing techniques along with their specific uses in cutaneous surgery. Numerous factors must be considered when choosing a wound closure material and suturing technique. These include wound tension, desire for wound edge eversion/inversion, desired hemostasis, repair type, patient's ability to care for the wound and return for suture removal, skin integrity, and wound location. Careful consideration of these factors and proper execution of suturing techniques can lead to excellent cosmetic results.

Genetic Susceptibility to Lymphoma

PubMed Central

Skibola, Christine F.; Curry, John D.; Nieters, Alexandra

2010-01-01

BACKGROUND Genetic susceptibility studies of lymphoma may serve to identify at risk populations and to elucidate important disease mechanisms. METHODS This review considered all studies published through October 2006 on the contribution of genetic polymorphisms in the risk of lymphoma. RESULTS Numerous studies implicate the role of genetic variants that promote B-cell survival and growth with increased risk of lymphoma. Several reports including a large pooled study by InterLymph, an international consortium of non-Hodgkin lymphoma (NHL) case-control studies, found positive associations between variant alleles in TNF -308G>A and IL10 -3575T>A genes and risk of diffuse large B-cell lymphoma. Four studies reported positive associations between a GSTT1 deletion and risk of Hodgkin and non-Hodgkin lymphoma. Genetic studies of folate-metabolizing genes implicate folate in NHL risk, but further studies that include folate and alcohol assessments are needed. Links between NHL and genes involved in energy regulation and hormone production and metabolism may provide insights into novel mechanisms implicating neuro- and endocrine-immune cross-talk with lymphomagenesis, but will need replication in larger populations. CONCLUSIONS Numerous studies suggest that common genetic variants with low penetrance influence lymphoma risk, though replication studies will be needed to eliminate false positive associations. PMID:17606447

Turbulent solutions of the equations of fluid motion

NASA Technical Reports Server (NTRS)

Deissler, R. G.

1984-01-01

Some turbulent solutions of the unaveraged Navier-Stokes equations (equations of fluid motion) are reviewed. Those equations are solved numerically in order to study the nonlinear physics of incompressible turbulent flow. Initial three-dimensional cosine velocity fluctuations and periodic boundary conditions are used in most of the work considered. The three components of the mean-square velocity fluctuations are initially equal for the conditions chosen. The resulting solutions show characteristics of turbulence such as the linear and nonlinear excitation of small-scale fluctuations. For the stronger fluctuations, the initially nonrandom flow develops into an apparently random turbulence. Thus randomness or turbulence can arise as a consequence of the structure of the Navier-Stokes equations. The cases considered include turbulence which is statistically homogeneous or inhomogeneous and isotropic or anisotropic. A mean shear is present in some cases. A statistically steady-state turbulence is obtained by using a spatially periodic body force. Various turbulence processes, including the transfer of energy between eddy sizes and between directional components, and the production, dissipation, and spatial diffusion of turbulence, are considered. It is concluded that the physical processes occurring in turbulence can be profitably studied numerically.

Characterization of a microbial consortium capable of rapid and simultaneous dechlorination of 1,1,2,2-tetrachloroethane and chlorinated ethane and ethene intermediates:

USGS Publications Warehouse

Jones, Elizabeth J.P.; Voytek, Mary A.; Lorah, Michelle M.; Kirshtein, Julie D.

2006-01-01

Mixed cultures capable of dechlorinating chlorinated ethanes and ethenes were enriched from contaminated wetland sediment at Aberdeen Proving Ground (APG) Maryland. The “West Branch Consortium” (WBC-2) was capable of degrading 1,1,2,2-tetrachloroethane (TeCA), trichloroethene (TCE), cis and trans 1,2-dichloroethene (DCE), 1,1,2-trichloroethane (TCA), 1,2-dichloroethane, and vinyl chloride to nonchlorinated end products ethene and ethane. WBC-2 dechlorinated TeCA, TCA, and cisDCE rapidly and simultaneously. A Clostridium sp. phylogenetically closely related to an uncultured member of a TCE-degrading consortium was numerically dominant in the WBC-2 clone library after 11 months of enrichment in culture. Clostridiales, including Acetobacteria, comprised 65% of the bacterial clones in WBC-2, with Bacteroides (14%), and epsilon Proteobacteria (14%) also numerically important. Methanogens identified in the consortium were members of the class Methanomicrobia, which includes acetoclastic methanogens. Dehalococcoidesdid not become dominant in the culture, although it was present at about 1% in the microbial population. The WBC-2 consortium provides opportunities for the in situbioremediation of sites contaminated with mixtures of chlorinated ethenes and ethanes.

Ocean modelling for aquaculture and fisheries in Irish waters

NASA Astrophysics Data System (ADS)

Dabrowski, T.; Lyons, K.; Cusack, C.; Casal, G.; Berry, A.; Nolan, G. D.

2015-06-01

The Marine Institute, Ireland, runs a suite of operational regional and coastal ocean models. Recent developments include several tailored products that focus on the key needs of the Irish aquaculture sector. In this article, an overview of the products and services derived from the models are presented. A shellfish model that includes growth and physiological interactions of mussels with the ecosystem and is fully embedded in the 3-D numerical modelling framework has been developed at the Marine Institute. This shellfish model has a microbial module designed to predict levels of coliform contamination in mussels. This model can also be used to estimate the carrying capacity of embayments, assess impacts of pollution on aquaculture grounds and help to classify shellfish waters. The physical coastal model of southwest Ireland provides a three day forecast of shelf water movement in the region. This is assimilated into a new harmful algal bloom alert system used to inform end-users of potential toxic shellfish events and high biomass blooms that include fish killing species. Further services include the use of models to identify potential sites for offshore aquaculture, to inform studies of potential cross-contamination in farms from the dispersal of planktonic sea lice larvae and other pathogens that can infect finfish and to provide modelled products that underpin the assessment and advisory services on the sustainable exploitation of the marine fisheries resources. This paper demonstrates that ocean models can provide an invaluable contribution to the sustainable blue growth of aquaculture and fisheries.

A Planning Guide for Small and Medium Size Wood Products Companies

Treesearch

Jeff Howe; Stephen Bratkovich

2005-01-01

At the beginning of the 21st century, North American wood products companies are facing competitive pressure from numerous sources. Traditional products are being manufactured in new regions (e.g., China and the developing nations), and substitute products are being developed by competing industries (e.g., plastics and composites). The bottom line is strained by...

A shock capturing technique for hypersonic, chemically relaxing flows

NASA Technical Reports Server (NTRS)

Eberhardt, S.; Brown, K.

1986-01-01

A fully coupled, shock capturing technique is presented for chemically reacting flows at high Mach numbers. The technique makes use of a total variation diminishing (TVD) dissipation operator which results in sharp, crisp shocks. The eigenvalues and eigenvectors of the fully coupled system, which includes species conversion equations in addition to the gas dynamics equations, are analytically derived for a general reacting gas. Species production terms for a model dissociating gas are introduced and are included in the algorithm. The convective terms are solved using a first-order TVD scheme while the source terms are solved using a fourth-order Runge-Kutta scheme to enhance stability. Results from one-dimensional numerical experiments are shown for a two species and a three species gas.

Many shades of gray—The context-dependent performance of organic agriculture

PubMed Central

Seufert, Verena; Ramankutty, Navin

2017-01-01

Organic agriculture is often proposed as a more sustainable alternative to current conventional agriculture. We assess the current understanding of the costs and benefits of organic agriculture across multiple production, environmental, producer, and consumer dimensions. Organic agriculture shows many potential benefits (including higher biodiversity and improved soil and water quality per unit area, enhanced profitability, and higher nutritional value) as well as many potential costs including lower yields and higher consumer prices. However, numerous important dimensions have high uncertainty, particularly the environmental performance when controlling for lower organic yields, but also yield stability, soil erosion, water use, and labor conditions. We identify conditions that influence the relative performance of organic systems, highlighting areas for increased research and policy support. PMID:28345054

CLIPS: A tool for the development and delivery of expert systems

NASA Technical Reports Server (NTRS)

Riley, Gary

1991-01-01

The C Language Integrated Production System (CLIPS) is a forward chaining rule-based language developed by the Software Technology Branch at the Johnson Space Center. CLIPS provides a complete environment for the construction of rule-based expert systems. CLIPS was designed specifically to provide high probability, low cost, and easy integration with external systems. Other key features of CLIPS include a powerful rule syntax, an interactive development environment, high performance, extensibility, a verification/validation tool, extensive documentation, and source code availability. The current release of CLIPS, version 4.3, is being used by over 2,500 users throughout the public and private community including: all NASA sites and branches of the military, numerous Federal bureaus, government contractors, 140 universities, and many companies.

Process simulation for advanced composites production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allendorf, M.D.; Ferko, S.M.; Griffiths, S.

1997-04-01

The objective of this project is to improve the efficiency and lower the cost of chemical vapor deposition (CVD) processes used to manufacture advanced ceramics by providing the physical and chemical understanding necessary to optimize and control these processes. Project deliverables include: numerical process models; databases of thermodynamic and kinetic information related to the deposition process; and process sensors and software algorithms that can be used for process control. Target manufacturing techniques include CVD fiber coating technologies (used to deposit interfacial coatings on continuous fiber ceramic preforms), chemical vapor infiltration, thin-film deposition processes used in the glass industry, and coatingmore » techniques used to deposit wear-, abrasion-, and corrosion-resistant coatings for use in the pulp and paper, metals processing, and aluminum industries.« less

Immunomodulatory dietary polysaccharides: a systematic review of the literature

PubMed Central

2010-01-01

Background A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides. Methods Studies were identified by conducting PubMed and Google Scholar electronic searches and through reviews of polysaccharide article bibliographies. Only articles published in English were included in this review. Two researchers reviewed data on study design, control, sample size, results, and nature of outcome measures. Subsequent searches were conducted to gather information about polysaccharide safety, structure and composition, and disposition. Results We found 62 publications reporting statistically significant effects of orally ingested glucans, pectins, heteroglycans, glucomannans, fucoidans, galactomannans, arabinogalactans and mixed polysaccharide products in rodents. Fifteen controlled human studies reported that oral glucans, arabinogalactans, heteroglycans, and fucoidans exerted significant effects. Although some studies investigated anti-inflammatory effects, most studies investigated the ability of oral polysaccharides to stimulate the immune system. These studies, as well as safety and toxicity studies, suggest that these polysaccharide products appear to be largely well-tolerated. Conclusions Taken as a whole, the oral polysaccharide literature is highly heterogenous and is not sufficient to support broad product structure/function generalizations. Numerous dietary polysaccharides, particularly glucans, appear to elicit diverse immunomodulatory effects in numerous animal tissues, including the blood, GI tract and spleen. Glucan extracts from the Trametes versicolor mushroom improved survival and immune function in human RCTs of cancer patients; glucans, arabinogalactans and fucoidans elicited immunomodulatory effects in controlled studies of healthy adults and patients with canker sores and seasonal allergies. This review provides a foundation that can serve to guide future research on immune modulation by well-characterized polysaccharide compounds. PMID:21087484

Effects of elevated turbidity and nutrients on the net production of a tropical seagrass community

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caldwell, J.W.

1985-01-01

Dredging effects on seagrass communities in the Florida Keys were examined by (1) comparing impacts on net production resulting from dredging and natural weather events, (2) determining changes in community photosynthetic efficiency, (3) evaluating shading and nutrient effects on net production, and (4) developing a systems dynamics model. Net community production was estimated during numerous meteorological and dredging events using the Odum-Hoskins oxygen technique in flow-through field microcosms. In other experiments, shading and nutrients (phosphorus, nitrate, and ammonia) were manipulated to simulate dredge plume conditions. The greatest depression in net community production resulted from severe thunderstorms and dredging events, respectively.more » In field microcosm experiments, significant interaction occurred between shading and nutrient concentration. The model of seagrass production was most sensitive to changes in nutrient-seagrass relationships, seagrass production estimates, and seagrass-light interactions. Recovery of seagrass biomass following numerous dredging events (3.5 years) was longer than that from the estimated total annual thunderstorms encountered (1 year) but shorter than recovery from hurricane events (4.1 years).« less

Producer-retailer integrated EMQ system with machine breakdown, rework failures, and a discontinuous inventory issuing policy.

PubMed

Chiu, Singa Wang; Chen, Shin-Wei; Chiu, Yuan-Shyi Peter; Li, Ting-Wei

2016-01-01

This study develops two extended economic manufacturing quantity (EMQ)-based models with a discontinuous product issuing policy, random machine breakdown, and rework failures. Various real conditions in production processes, end-product delivery, and intra-supply chains such as a producer-retailer integrated scheme are examined. The first model incorporates a discontinuous multi-delivery policy into a prior work (Chiu et al. in Proc Inst Mech Eng B J Eng 223:183-194, 2009) in lieu of their continuous policy. Such an enhanced model can address situations in supply chain environments, where finished products are transported to outside retail stores (or customers). The second model further combines retailer's stock holding costs into the first model. This extended EMQ model is applicable in situations in present-day manufacturing firms where finished products are distributed to company's own retail stores (or regional sales offices) and stocked there for sale. Two aforementioned extended EMQ models are investigated, respectively. Mathematical modeling along with iterative algorithms are employed to derive the optimal production run times that minimize the expected total system costs, including the costs incurred in production units, transportation, and retail stores, for these integrated EMQ systems. Numerical examples are provided to demonstrate the practical application of the research results.

An outbreak of aflatoxin poisoning in dogs associated with aflatoxin B1-contaminated maize products.

PubMed

Wouters, Angelica Terezinha Barth; Casagrande, Renata Assis; Wouters, Flademir; Watanabe, Tatiane Terumi Negrão; Boabaid, Fabiana Marques; Cruz, Cláudio Estêvão Farias; Driemeier, David

2013-03-01

An aflatoxicosis outbreak affected 65 dogs from 9 different farms after they were fed diets with cooked corn meal as a common ingredient. Of the dogs, 60 died. Numerous dogs died on additional farms, but those dogs were not included in the study. The farmers acquired the contaminated maize products, in the form of whole corn grain or as corn meal, from the same supplier. The corn product was mixed with meat that was left over from home or commercial rations to form corn polenta, which was fed to the dogs. Necropsy was performed on 3 dogs. Two of the dogs died after a few days of refusing food, showing anorexia, polydipsia, icteric mucous membranes, hematemesis, hematochezia, or melena, and bleeding of the skin, eye, ear, and mouth. The primary necropsy findings included jaundice, hemorrhages in several organs, and yellowish enlarged liver with enhanced lobular pattern. The dog that experienced chronic ascites had a yellowish liver with reduced volume, irregular surface, and increased consistency. The main histological findings included hepatocyte fatty degeneration, biliary duct hyperplasia, cholestasis and, in the chronic case, hepatic fibrosis. High-performance liquid chromatography analysis of the corn meal from 2 affected farms revealed 1,640 ppb and 1,770 ppb of aflatoxin B1, respectively. The current study demonstrates an additional way that dogs can be exposed to, poisoned, and killed by aflatoxin.

[Medical certification in workers involved in logging and wood-processing].

PubMed

Romankow, Jacek

2007-01-01

Activities involved in forestry and woodworking industry are associated with workers being exposed to numerous environmental and technology-related factors that are detrimental to their health. Such hazards include working in changeable climatic conditions, in the vicinity of heavy equipment, exposure to noise, chainsaw vibrations, enforced body positioning, hard physical work, the effect of exhaust gases, potential effects of biological factors, including epizootic diseases. Wood processing involves performing mechanical activities employing tools and machines, as well as processes utilizing various chemical substances. Forestry and woodworking industry workers may deal both with timber and with wood products. In medical certification, the following issues are of significance: work in the vicinity of rotational elements, noise, effects of chemicals or biological factors, including carcinogenic substances. For this reason, the procedures involved in medical examinations of such workers are complex.

Use of SeaWiFS, MODIS, and MERIS in developing water quality numeric criteria for Florida’s coastal waters

EPA Science Inventory

Human activities on land often increase nutrient loads to coastal waters and may cause increased phytoplankton production, algal biomass, and eutrophication. The U. S. Environmental Protection Agency determined that numeric criteria were necessary to protect Florida's coastal wa...

Review of problems in the small-scale farm production of ethanol

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, H.M.

1983-07-01

This report reviews the current status of small, farmer-operated ethanol production facilities. The characteristics and operating problems associated with present plants are reviewed with respect to technical, economic, and institutional issues. Information was obtained from recent publications and numerous telephone calls to state and federal officials and the producers themselves. It is concluded that, in most parts of the country, small-scale alcohol production has been reduced to relatively few farm plants, due primarily to several unfavorable economic factors. While both large and small facilities have been squeezed by rising feedstock costs and lower alcohol selling prices, the farmer-producer is burdenedmore » by additional constraints because of the small scale of his operations. It is not usually profitable for him to recover all the valuable by-products from the feedstock, such as gluten, corn oil, and carbon dioxide from corn conversion. He may not be able to use or market the wet alcohol and stillage he produces. Other difficulties often include high fuel costs, lack of financial and technical assistance, and excessive labor requirements.« less

Manufacturing and Security Challenges in 3D Printing

NASA Astrophysics Data System (ADS)

Zeltmann, Steven Eric; Gupta, Nikhil; Tsoutsos, Nektarios Georgios; Maniatakos, Michail; Rajendran, Jeyavijayan; Karri, Ramesh

2016-07-01

As the manufacturing time, quality, and cost associated with additive manufacturing (AM) continue to improve, more and more businesses and consumers are adopting this technology. Some of the key benefits of AM include customizing products, localizing production and reducing logistics. Due to these and numerous other benefits, AM is enabling a globally distributed manufacturing process and supply chain spanning multiple parties, and hence raises concerns about the reliability of the manufactured product. In this work, we first present a brief overview of the potential risks that exist in the cyber-physical environment of additive manufacturing. We then evaluate the risks posed by two different classes of modifications to the AM process which are representative of the challenges that are unique to AM. The risks posed are examined through mechanical testing of objects with altered printing orientation and fine internal defects. Finite element analysis and ultrasonic inspection are also used to demonstrate the potential for decreased performance and for evading detection. The results highlight several scenarios, intentional or unintentional, that can affect the product quality and pose security challenges for the additive manufacturing supply chain.

Experimental Investigations to evaluate the effects of cutting parameters on cutting temperature and residual stresses during milling process of the AISI 1045

NASA Astrophysics Data System (ADS)

Abdelkrim, M.; Brabie, G.; Belloufi, A.; Catalin, T.; Chirita, B.

2017-08-01

Today major metal cutting companies in industrial countries, looking to gain time and reduce manufacturing costs while respecting the environment. There are many phenomena which affect the quality and production costs of the product, including cutting efforts, cutting temperature, residual stresses, etc. A better understanding of these phenomena will reduce production costs and maximize productivity. The aim of this work is to analyze the effect of machining conditions (cutting speed, feed speed and cutting depth) on cutting temperature and residual stresses, during the milling operations using the response surface method. A good accuracy between predicted and measured values of the cutting temperature was found, the cutting speed and the depth of cut are parameters whose effect is most sensitive to the residual stresses and the cutting temperature.However, little influence has been registered in the case of an increase of the feed rate. The percentage of error is 4.57%, indicating that the numerical approach can accurately predict the cutting temperature of the AISI 1045.

The identification of fungi collected from the ceca of commercial poultry.

PubMed

Byrd, J A; Caldwell, D Y; Nisbet, D J

2017-07-01

Under normal conditions, fungi are ignored unless a disease/syndrome clinical signs are reported. The scientific communities are largely unaware of the roles fungi play in normal production parameters. Numerous preharvest interventions have demonstrated that beneficial bacteria can play a role in improving productions parameters; however, most researchers have ignored the impact that fungi may have on production. The goal of the present study was to record fungi recovered from commercial broiler and layer houses during production. Over 3,000 cecal samples were isolated using conventional culture methodology and over 890 samples were further characterized using an automated repetitive sequence-based PCR (rep-PCR) methodology. Eighty-eight different fungal and yeast species were identified, including Aspergillus spp., Penicillium spp., and Sporidiobolus spp, and 18 unknown genera were separated using rep-PCR. The results from the present study will provide a normal fungi background genera under commercial conditions and will be a stepping stone for investigating the impact of fungi on the gastrointestinal tract and on the health of poultry. Published by Oxford University Press on behalf of Poultry Science Association 2017.

Uranium deposits of Brazil

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Brazil is a country of vast natural resources, including numerous uranium deposits. In support of the country`s nuclear power program, Brazil has developed the most active uranium industry in South America. Brazil has one operating reactor (Angra 1, a 626-MWe PWR), and two under construction. The country`s economic challenges have slowed the progress of its nuclear program. At present, the Pocos de Caldas district is the only active uranium production. In 1990, the Cercado open-pit mine produced approximately 45 metric tons (MT) U{sub 3}O{sub 8} (100 thousand pounds). Brazil`s state-owned uranium production and processing company, Uranio do Brasil, announced itmore » has decided to begin shifting its production from the high-cost and nearly depleted deposits at Pocos de Caldas, to lower-cost reserves at Lagoa Real. Production at Lagoa Real is schedules to begin by 1993. In addition to these two districts, Brazil has many other known uranium deposits, and as a whole, it is estimated that Brazil has over 275,000 MT U{sub 3}O{sub 8} (600 million pounds U{sub 3}O{sub 8}) in reserves.« less

Preface of "The Second Symposium on Border Zones Between Experimental and Numerical Application Including Solution Approaches By Extensions of Standard Numerical Methods"

NASA Astrophysics Data System (ADS)

Ortleb, Sigrun; Seidel, Christian

2017-07-01

In this second symposium at the limits of experimental and numerical methods, recent research is presented on practically relevant problems. Presentations discuss experimental investigation as well as numerical methods with a strong focus on application. In addition, problems are identified which require a hybrid experimental-numerical approach. Topics include fast explicit diffusion applied to a geothermal energy storage tank, noise in experimental measurements of electrical quantities, thermal fluid structure interaction, tensegrity structures, experimental and numerical methods for Chladni figures, optimized construction of hydroelectric power stations, experimental and numerical limits in the investigation of rain-wind induced vibrations as well as the application of exponential integrators in a domain-based IMEX setting.

Regeneration and productivity of aspen grown on repeated short rotations.

Treesearch

Donald A. Perala

1979-01-01

Regeneration and productivity of aspen cannot be sustained on rotations shorter than about 8 years. Productivity losses on short rotations are physiological and morphological rather than nutritional in nature. Stump and root collar sprouts, which are rare in mature stands, were more numerous than root suckers.

76 FR 14687 - In the Matter of Certain Semiconductor Chips and Products Containing Same; Notice of Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-17

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-753] In the Matter of Certain Semiconductor Chips and Products Containing Same; Notice of Commission Determination Not To Review an Initial... semiconductor chips and products containing the same. The Commission's notice of investigation named numerous...

Process economics of renewable biorefineries: butanol and ethanol production in integrated bioprocesses from lignocellulosics and other industrial by-products

USDA-ARS?s Scientific Manuscript database

This chapter provides process economic details on production of butanol from lignocellulosic biomass and glycerol in integrated bioreactors where numerous unit operations are combined. In order to compare various processes, economic evaluations were performed using SuperPro Designer Software (versio...

TREATMENT OF LONG-EVANS RATS WITH A DEFINED MIXTURE OF DRINKING WATER DISINFECTION BY-PRODUCTS IMPACTS INTESTINAL MICROBIAL METABOLISM.

EPA Science Inventory

Water treatment results in the production of numerous halogenated disinfection by-products (DBPs), and has been associated with human colorectal cancer. Because the intestinal microbiota can bioactivate promutagens and procarcinogens, several studies have been done to examine the...

Biotechnology for improved hHydroxy fatty acid production in oilseed lesquerella

USDA-ARS?s Scientific Manuscript database

The conventional source of hydroxy fatty acid (HFA) is from castor (Ricinus communis), 90% of castor oil is ricinoleic acid (18:1OH). Ricinoleic acid and its derivatives are used as raw materials for numerous industrial products, such as lubricants, plasticizers and surfactants. The production of ca...

AN ADA LINEAR ALGEBRA PACKAGE MODELED AFTER HAL/S

NASA Technical Reports Server (NTRS)

Klumpp, A. R.

1994-01-01

This package extends the Ada programming language to include linear algebra capabilities similar to those of the HAL/S programming language. The package is designed for avionics applications such as Space Station flight software. In addition to the HAL/S built-in functions, the package incorporates the quaternion functions used in the Shuttle and Galileo projects, and routines from LINPAK that solve systems of equations involving general square matrices. Language conventions in this package follow those of HAL/S to the maximum extent practical and minimize the effort required for writing new avionics software and translating existent software into Ada. Valid numeric types in this package include scalar, vector, matrix, and quaternion declarations. (Quaternions are fourcomponent vectors used in representing motion between two coordinate frames). Single precision and double precision floating point arithmetic is available in addition to the standard double precision integer manipulation. Infix operators are used instead of function calls to define dot products, cross products, quaternion products, and mixed scalar-vector, scalar-matrix, and vector-matrix products. The package contains two generic programs: one for floating point, and one for integer. The actual component type is passed as a formal parameter to the generic linear algebra package. The procedures for solving systems of linear equations defined by general matrices include GEFA, GECO, GESL, and GIDI. The HAL/S functions include ABVAL, UNIT, TRACE, DET, INVERSE, TRANSPOSE, GET, PUT, FETCH, PLACE, and IDENTITY. This package is written in Ada (Version 1.2) for batch execution and is machine independent. The linear algebra software depends on nothing outside the Ada language except for a call to a square root function for floating point scalars (such as SQRT in the DEC VAX MATHLIB library). This program was developed in 1989, and is a copyrighted work with all copyright vested in NASA.

Numerical Simulation of Non-Thermal Food Preservation

NASA Astrophysics Data System (ADS)

Rauh, C.; Krauss, J.; Ertunc, Ö.; Delgado, a.

2010-09-01

Food preservation is an important process step in food technology regarding product safety and product quality. Novel preservation techniques are currently developed, that aim at improved sensory and nutritional value but comparable safety than in conventional thermal preservation techniques. These novel non-thermal food preservation techniques are based for example on high pressures up to one GPa or pulsed electric fields. in literature studies the high potential of high pressures (HP) and of pulsed electric fields (PEF) is shown due to their high retention of valuable food components as vitamins and flavour and selective inactivation of spoiling enzymes and microorganisms. for the design of preservation processes based on the non-thermal techniques it is crucial to predict the effect of high pressure and pulsed electric fields on the food components and on the spoiling enzymes and microorganisms locally and time-dependent in the treated product. Homogenous process conditions (especially of temperature fields in HP and PEF processing and of electric fields in PEF) are aimed at to avoid the need of over-processing and the connected quality loss and to minimize safety risks due to under-processing. the present contribution presents numerical simulations of thermofluiddynamical phenomena inside of high pressure autoclaves and pulsed electric field treatment chambers. in PEF processing additionally the electric fields are considered. Implementing kinetics of occurring (bio-) chemical reactions in the numerical simulations of the temperature, flow and electric fields enables the evaluation of the process homogeneity and efficiency connected to different process parameters of the preservation techniques. Suggestions to achieve safe and high quality products are concluded out of the numerical results.

Degradation Processes of Pesticides Used in Potato Cultivations.

PubMed

Kurek, M; Barchańska, H; Turek, M

Potato is one of the most important crops, after maize, rice and wheat. Its global production is about 300 million tons per year and is constantly increasing. It grows in temperate climate and is used as a source of starch, food, and in breeding industry.Potato cultivation requires application of numerous agro-technical products, including pesticides, since it can be affected by insects, weeds, fungi, and viruses. In the European Union the most frequently used pesticides in potato cultivations check are: thiamethoxam, lambda-cyhalothrin and deltamethrin (insecticides), rimsulfuron (herbicide) and metalaxyl (fungicide).Application of pesticides improves crop efficiency, however, as pesticides are not totally selective, it affects also non-target organisms. Moreover, the agrochemicals may accumulate in crops and, as a consequence, negatively influence the quality of food products and consumer health. Additional risks of plant protection products are related to their derivatives, that are created both in the environment (soil, water) and in plant organisms, since many of these compounds may exhibit toxic effects.This article is devoted to the degradation processes of pesticides used in potato crop protection. Attention is also paid to the toxicity of both parent compounds and their degradation products for living organisms, including humans. Information about the level of pesticide contamination in the environment (water, soil) and accumulation level in edible plants complement the current knowledge about the risks associated with widespread use of thiamethoxam, lambda-cyhalothrin and deltamethrin, rimsulfuron and metalaxyl in potato cultivation.

Ten Years of Cloud Properties from MODIS: Global Statistics and Use in Climate Model Evaluation

NASA Technical Reports Server (NTRS)

Platnick, Steven E.

2011-01-01

The NASA Moderate Resolution Imaging Spectroradiometer (MODIS), launched onboard the Terra and Aqua spacecrafts, began Earth observations on February 24, 2000 and June 24,2002, respectively. Among the algorithms developed and applied to this sensor, a suite of cloud products includes cloud masking/detection, cloud-top properties (temperature, pressure), and optical properties (optical thickness, effective particle radius, water path, and thermodynamic phase). All cloud algorithms underwent numerous changes and enhancements between for the latest Collection 5 production version; this process continues with the current Collection 6 development. We will show example MODIS Collection 5 cloud climatologies derived from global spatial . and temporal aggregations provided in the archived gridded Level-3 MODIS atmosphere team product (product names MOD08 and MYD08 for MODIS Terra and Aqua, respectively). Data sets in this Level-3 product include scalar statistics as well as 1- and 2-D histograms of many cloud properties, allowing for higher order information and correlation studies. In addition to these statistics, we will show trends and statistical significance in annual and seasonal means for a variety of the MODIS cloud properties, as well as the time required for detection given assumed trends. To assist in climate model evaluation, we have developed a MODIS cloud simulator with an accompanying netCDF file containing subsetted monthly Level-3 statistical data sets that correspond to the simulator output. Correlations of cloud properties with ENSO offer the potential to evaluate model cloud sensitivity; initial results will be discussed.

Mixing-dependent Reactions in the Hyporheic Zone: Laboratory and Numerical Experiments

NASA Astrophysics Data System (ADS)

Santizo, K. Y.; Eastes, L. A.; Hester, E. T.; Widdowson, M.

2017-12-01

The hyporheic zone is the surface water-groundwater interface surrounding the river's perimeter. Prior research demonstrates the ability of the hyporheic zone to attenuate pollutants when surface water cycles through reactive sediments (non-mixing-dependent reactions). However, the colocation of both surface and ground water within hyporheic sediments also allows mixing-dependent reactions that require mixing of reactants from these two water sources. Recent modeling studies show these mixing zones can be small under steady state homogeneous conditions, but do not validate those results in the laboratory or explore the range of hydrological characteristics that control the extent of mixing. Our objective was to simulate the mixing zone, quantify its thickness, and probe its hydrological controls using a "mix" of laboratory and numerical experiments. For the lab experiments, a hyporheic zone was simulated in a sand mesocosm, and a mixing-dependent abiotic reaction of sodium sulfite and dissolved oxygen was induced. Oxygen concentration response and oxygen consumption were visualized via planar optodes. Sulfate production by the mixing-dependent reaction was measured by fluid samples and a spectrophometer. Key hydrologic controls varied in the mesocosm included head gradient driving hyporheic exchange and hydraulic conductivity/heterogeneity. Results show a clear mixing area, sulfate production, and oxygen gradient. Mixing zone length (hyporheic flow cell size) and thickness both increase with the driving head gradient. For the numerical experiments, transient surface water boundary conditions were implemented together with heterogeneity of hydraulic conductivity. Results indicate that both fluctuating boundary conditions and heterogeneity increase mixing-dependent reaction. The hyporheic zone is deemed an attenuation hotspot by multiple studies, but here we demonstrate its potential for mixing-dependent reactions and the influence of important hydrological parameters.

Using Copper to Improve the Well-Being of the Skin

PubMed Central

Borkow, Gadi

2014-01-01

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete’s foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being. PMID:26361585

Top Quark Pair Production in Association with a Jet with Next-to-Leading-Order QCD Off-Shell Effects at the Large Hadron Collider.

PubMed

Bevilacqua, G; Hartanto, H B; Kraus, M; Worek, M

2016-02-05

We present a complete description of top quark pair production in association with a jet in the dilepton channel. Our calculation is accurate to next-to-leading order (NLO) in QCD and includes all nonresonant diagrams, interferences, and off-shell effects of the top quark. Moreover, nonresonant and off-shell effects due to the finite W gauge boson width are taken into account. This calculation constitutes the first fully realistic NLO computation for top quark pair production with a final state jet in hadronic collisions. Numerical results for differential distributions as well as total cross sections are presented for the Large Hadron Collider at 8 TeV. With our inclusive cuts, NLO predictions reduce the unphysical scale dependence by more than a factor of 3 and lower the total rate by about 13% compared to leading-order QCD predictions. In addition, the size of the top quark off-shell effects is estimated to be below 2%.

Key technologies for manufacturing and processing sheet materials: A global perspective

NASA Astrophysics Data System (ADS)

Demeri, Mahmoud Y.

2001-02-01

Modern industrial technologies continue to seek new materials and processes to produce products that meet design and functional requirements. Sheet materials made from ferrous and non-ferrous metals, laminates, composites, and reinforced plastics constitute a large percentage of today’s products, components, and systems. Major manufacturers of sheet products include automotive, aerospace, appliance, and food-packaging industries. The Second Global Symposium on Innovations in Materials Processing & Manufacturing: Sheet Materials is organized to provide a forum for presenting advances in sheet processing and manufacturing by worldwide researchers and engineers from industrial, research, and academic centers. The symposium, sponsored by the TMS Materials Processing & Manufacturing Division (MPMD), was planned for the 2001 TMS Annual Meeting, New Orleans, Louisiana, February 11 15, 2001. This article is a review of key papers submitted for publication in the concurrent volume. The selected papers present significant developments in the rapidly expanding areas of advanced sheet materials, innovative forming methods, industrial applications, primary and secondary processing, composite processing, and numerical modeling of manufacturing processes.

Numerical study on injection parameters optimization of thin wall and biodegradable polymers parts

NASA Astrophysics Data System (ADS)

Santos, C.; Mendes, A.; Carreira, P.; Mateus, A.; Malça, C.

2017-07-01

Nowadays, the molds industry searches new markets, with diversified and added value products. The concept associated to the production of thin walled and biodegradable parts mostly manufactured by injection process has assumed a relevant importance due to environmental and economic factors. The growth of a global consciousness about the harmful effects of the conventional polymers in our life quality associated with the legislation imposed, become key factors for the choice of a particular product by the consumer. The target of this work is to provide an integrated solution for the injection of parts with thin walls and manufactured using biodegradable materials. This integrated solution includes the design and manufacture processes of the mold as well as to find the optimum values for the injection parameters in order to become the process effective and competitive. For this, the Moldflow software was used. It was demonstrated that this computational tool provides an effective responsiveness and it can constitute an important tool in supporting the injection molding of thin-walled and biodegradable parts.

Division of energy biosciences: Annual report and summaries of FY 1995 activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-04-01

The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicalsmore » by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.« less

Reinjected water return at Miravalles geothermal reservoir, Costa Rica: Numerical modelling and observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parini, Mauro; Acuna, Jorge A.; Laudiano, Michele

1996-01-24

The first 55 MW power plant at Miravalles started operation in March, 1994. During the first few months of production, a gradual increase in chloride content was observed in some production wells. The cause was assumed to be a rapid return of injectate from two in.jection wells located fairly near to the main production area. A tracer test was performed and showed a relatively rapid breakthrough, confirming the assumption made. Numerical modeling was then carried out to try to reproduce the observed behavior. The reservoir was modelled with an idealized three-dimensional network of fractures embedded into a low permeability matrix.more » The “two waters” feature of TOUGH2 simulator was used. The numerical simulation showed good agreement with observations. A “porous medium” model with equivalent hydraulic characteristics was unable to reproduce the observations. The fractured model, when applied to investigate the mid and long term expected behavior, indicated a reservoir cooling risk associated to the present injection scheme. Work is currently underway to modify this scheme.« less

Reinjected water return at Miravalles geothermal reservoir, Costa Rica: Numerical modelling and observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parini, M.; Laudiano, M.; Acuna, J.A.

1996-12-31

The first 55 MW power plant at Miravalles started operation in March, 1994. During the first few months of production, a gradual increase in chloride content was observed in some production wells. The cause was assumed to be a rapid return of injectate from two injection wells located fairly near to the main production area. A tracer test was performed and showed a relatively rapid breakthrough, confirming the assumption made. Numerical modeling was then carried out to try to reproduce the observed behavior. The reservoir was modelled with an idealized three-dimensional network of fractures embedded into a low permeability matrix.more » The {open_quotes}two waters{close_quotes} feature of TOUGH2 simulator was used. The numerical simulation showed good agreement with observations. A {open_quotes}porous medium{close_quotes} model with equivalent hydraulic characteristics was unable to reproduce the observations. The fractured model, when applied to investigate the mid and long term expected behavior, indicated a reservoir cooling risk associated to the present injection scheme. Work is currently underway to modify this scheme.« less

Preparing the remote sensing community toward the NPP/NPOESS era

NASA Astrophysics Data System (ADS)

Kuciauskas, A. P.; Lee, T. F.; Turk, F. J.; Richardson, K. A.; Hawkins, J. D.; Kent, J. E.; Miller, S. D.; McWilliams, G.

2008-12-01

Under the auspices of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) Integrated Program Office (IPO), the Naval Research Laboratory in Monterey (NRLMRY) was tasked to develop NexSat, a weather satellite web-based resource, to illustrate future sensing capabilities within the Visible/Infrared Imager Radiometer Suite (VIIRS) sensor onboard the NPOESS Preparatory Project (NPP) and NPOESS era. NexSat acquires and processes data from polar orbiters (AVHRR, MODIS, SeaWiFS, DMSP, and TRMM) that serve as heritage instruments to the VIIRS. Geostationary sensors and numerical weather prediction (NWP) overlays supplement the image products suite, making NexSat a one-stop shop for current and future environmental monitoring. NRLMRY collaborates with the Cooperative Institute for Research in the Atmosphere (CIRA) and the Cooperative Institute for Meteorological Satellite Studies (CIMSS) for product development. Together with the Cooperative Program for Operational Meteorology, Education and Training (COMET®), NRLMRY provides educational outreach to research and development communities as well as to the general public. This paper intends to describe the products within the NexSat webpage and its training resources. The product suite consists of generic and state of the art images. Along with the standard visible, IR, and water vapor products, NexSat also includes dust enhancement, cloud properties, cloud profiling, snow cloud discrimination, volcanic ash plumes, hot spots, aerosol content over land and water. NexSat training resources will be described, including on-line product tutorials, a course module, as well as outreach efforts to the National Weather Service, government agencies, academic institutions, and international organizations.

Food safety hazards associated with consumption of raw milk.

PubMed

Oliver, Stephen P; Boor, Kathryn J; Murphy, Steven C; Murinda, Shelton E

2009-09-01

An increasing number of people are consuming raw unpasteurized milk. Enhanced nutritional qualities, taste, and health benefits have all been advocated as reasons for increased interest in raw milk consumption. However, science-based data to substantiate these claims are limited. People continue to consume raw milk even though numerous epidemiological studies have shown clearly that raw milk can be contaminated by a variety of pathogens, some of which are associated with human illness and disease. Several documented milkborne disease outbreaks occurred from 2000-2008 and were traced back to consumption of raw unpasteurized milk. Numerous people were found to have infections, some were hospitalized, and a few died. In the majority of these outbreaks, the organism associated with the milkborne outbreak was isolated from the implicated product(s) or from subsequent products made at the suspected dairy or source. In contrast, fewer milkborne disease outbreaks were associated with consumption of pasteurized milk during this same time period. Twenty nine states allow the sale of raw milk by some means. Direct purchase, cow-share or leasing programs, and the sale of raw milk as pet food have been used as means for consumers to obtain raw milk. Where raw milk is offered for sale, strategies to reduce risks associated with raw milk and products made from raw milk are needed. Developing uniform regulations including microbial standards for raw milk to be sold for human consumption, labeling of raw milk, improving sanitation during milking, and enhancing and targeting educational efforts are potential approaches to this issue. Development of pre- and postharvest control measures to effectively reduce contamination is critical to the control of pathogens in raw milk. One sure way to prevent raw milk-associated foodborne illness is for consumers to refrain from drinking raw milk and from consuming dairy products manufactured using raw milk.

An overview of C. elegans biology.

PubMed

Strange, Kevin

2006-01-01

The establishment of Caenorhabditis elegans as a "model organism" began with the efforts of Sydney Brenner in the early 1960s. Brenner's focus was to find a suitable animal model in which the tools of genetic analysis could be used to define molecular mechanisms of development and nervous system function. C. elegans provides numerous experimental advantages for such studies. These advantages include a short life cycle, production of large numbers of offspring, easy and inexpensive laboratory culture, forward and reverse genetic tractability, and a relatively simple anatomy. This chapter will provide a brief overview of C. elegans biology.

The rationale for consuming protein blends in sports nutrition.

PubMed

Paul, Gregory L

2009-08-01

Protein is considered by many to be the most important macronutrient for humans because of the numerous roles protein plays in the body. Protein needs have been compared across several population groups, including athletes and other exercising individuals. Many researchers have compared the effects of ingesting animal and vegetable protein sources and their implications on sports performance. Recently, blends of dairy protein and soy protein have appeared in commercial sports nutrition products such as nutrition bars and ready-to-drink and powdered beverages. This review will focus on the potential nutritional advantages of combining whey protein, casein, and isolated soy protein.

Bi-parentally inherited species-specific markers identify hybridization between rainbow trout and cutthroat trout subspecies

USGS Publications Warehouse

Ostberg, C.O.; Rodriguez, R.J.

2004-01-01

Eight polymerase chain reaction primer sets amplifying bi-parentally inherited species-specific markers were developed that differentiate between rainbow trout (Oncorhynchus mykiss) and various cutthroat trout (O. clarki) subspecies. The primers were tested within known F1 and first generation hybrid backcrosses and were shown to amplify codominantly within hybrids. Heterozygous individuals also amplified a slower migrating band that was a heteroduplex, caused by the annealing of polymerase chain reaction products from both species. These primer sets have numerous advantages for native cutthroat trout conservation including statistical genetic analyses of known crosses and simple hybrid identification.

Supporting clinician educators to achieve "work-work balance".

PubMed

Maniate, Jerry; Dath, Deepak; Cooke, Lara; Leslie, Karen; Snell, Linda; Busari, Jamiu

2016-10-01

Clinician Educators (CE) have numerous responsibilities in different professional domains, including clinical, education, research, and administration. Many CEs face tensions trying to manage these often competing professional responsibilities and achieve "work-work balance." Rich discussions of techniques for work-work balance amongst CEs at a medical education conference inspired the authors to gather, analyze, and summarize these techniques to share with others. In this paper we present the CE's "Four Ps"; these are practice points that support both the aspiring and established CE to help improve their performance and productivity as CEs, and allow them to approach work-work balance.

Status of the NASA Micro Pulse Lidar Network (MPLNET): overview of the network and future plans, new version 3 data products, and the polarized MPL

NASA Astrophysics Data System (ADS)

Welton, Ellsworth J.; Stewart, Sebastian A.; Lewis, Jasper R.; Belcher, Larry R.; Campbell, James R.; Lolli, Simone

2018-04-01

The NASA Micro Pulse Lidar Network (MPLNET) is a global federated network of Micro-Pulse Lidars (MPL) co-located with the NASA Aerosol Robotic Network (AERONET). MPLNET began in 2000, and there are currently 17 long-term sites, numerous field campaigns, and more planned sites on the way. We have developed a new Version 3 processing system including the deployment of polarized MPLs across the network. Here we provide an overview of Version 3, the polarized MPL, and current and future plans.

Meteorological and Environmental Inputs to Aviation Systems

NASA Technical Reports Server (NTRS)

Camp, Dennis W. (Editor); Frost, Walter (Editor)

1988-01-01

Reports on aviation meteorology, most of them informal, are presented by representatives of the National Weather Service, the Bracknell (England) Meteorological Office, the NOAA Wave Propagation Lab., the Fleet Numerical Oceanography Center, and the Aircraft Owners and Pilots Association. Additional presentations are included on aircraft/lidar turbulence comparison, lightning detection and locating systems, objective detection and forecasting of clear air turbulence, comparative verification between the Generalized Exponential Markov (GEM) Model and official aviation terminal forecasts, the evaluation of the Prototype Regional Observation and Forecast System (PROFS) mesoscale weather products, and the FAA/MIT Lincoln Lab. Doppler Weather Radar Program.

A programing system for research and applications in structural optimization

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Rogers, J. L., Jr.

1981-01-01

The flexibility necessary for such diverse utilizations is achieved by combining, in a modular manner, a state-of-the-art optimization program, a production level structural analysis program, and user supplied and problem dependent interface programs. Standard utility capabilities in modern computer operating systems are used to integrate these programs. This approach results in flexibility of the optimization procedure organization and versatility in the formulation of constraints and design variables. Features shown in numerical examples include: variability of structural layout and overall shape geometry, static strength and stiffness constraints, local buckling failure, and vibration constraints.

Canine and feline blood transfusions: controversies and recent advances in administration practices.

PubMed

Kisielewicz, Caroline; Self, Ian A

2014-05-01

To discuss and review blood transfusion practices in dogs and cats including collection and storage of blood and administration of products. To report new developments, controversial practices, less conventional blood product administration techniques and where applicable, describe the relevance to anaesthetists and anaesthesia. PubMed and Google Scholar using dog, cat, blood transfusion, packed red blood cells and whole blood as keywords. Blood transfusions improve oxygen carrying capacity and the clinical signs of anaemia. However there are numerous potential risks and complications possible with transfusions, which may outweigh their benefits. Storage of blood products has improved considerably over time but whilst extended storage times may improve their availability, a phenomenon known as the storage lesion has been identified which affects erythrocyte viability and survival. Leukoreduction involves removing leukocytes and platelets thereby preventing their release of cytokines and bioactive compounds which also contribute to storage lesions and certain transfusion reactions. Newer transfusion techniques are being explored such as cell salvage in surgical patients and subsequent autologous transfusion. Xenotransfusions, using blood and blood products between different species, provide an alternative to conventional blood products. © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Integrative modelling reveals mechanisms linking productivity and plant species richness.

PubMed

Grace, James B; Anderson, T Michael; Seabloom, Eric W; Borer, Elizabeth T; Adler, Peter B; Harpole, W Stanley; Hautier, Yann; Hillebrand, Helmut; Lind, Eric M; Pärtel, Meelis; Bakker, Jonathan D; Buckley, Yvonne M; Crawley, Michael J; Damschen, Ellen I; Davies, Kendi F; Fay, Philip A; Firn, Jennifer; Gruner, Daniel S; Hector, Andy; Knops, Johannes M H; MacDougall, Andrew S; Melbourne, Brett A; Morgan, John W; Orrock, John L; Prober, Suzanne M; Smith, Melinda D

2016-01-21

How ecosystem productivity and species richness are interrelated is one of the most debated subjects in the history of ecology. Decades of intensive study have yet to discern the actual mechanisms behind observed global patterns. Here, by integrating the predictions from multiple theories into a single model and using data from 1,126 grassland plots spanning five continents, we detect the clear signals of numerous underlying mechanisms linking productivity and richness. We find that an integrative model has substantially higher explanatory power than traditional bivariate analyses. In addition, the specific results unveil several surprising findings that conflict with classical models. These include the isolation of a strong and consistent enhancement of productivity by richness, an effect in striking contrast with superficial data patterns. Also revealed is a consistent importance of competition across the full range of productivity values, in direct conflict with some (but not all) proposed models. The promotion of local richness by macroecological gradients in climatic favourability, generally seen as a competing hypothesis, is also found to be important in our analysis. The results demonstrate that an integrative modelling approach leads to a major advance in our ability to discern the underlying processes operating in ecological systems.

Gene therapy for cancer: regulatory considerations for approval.

PubMed

Husain, S R; Han, J; Au, P; Shannon, K; Puri, R K

2015-12-01

The rapidly changing field of gene therapy promises a number of innovative treatments for cancer patients. Advances in genetic modification of cancer and immune cells and the use of oncolytic viruses and bacteria have led to numerous clinical trials for cancer therapy, with several progressing to late-stage product development. At the time of this writing, no gene therapy product has been approved by the United States Food and Drug Administration (FDA). Some of the key scientific and regulatory issues include understanding of gene transfer vector biology, safety of vectors in vitro and in animal models, optimum gene transfer, long-term persistence or integration in the host, shedding of a virus and ability to maintain transgene expression in vivo for a desired period of time. Because of the biological complexity of these products, the FDA encourages a flexible, data-driven approach for preclinical safety testing programs. The clinical trial design should be based on the unique features of gene therapy products, and should ensure the safety of enrolled subjects. This article focuses on regulatory considerations for gene therapy product development and also discusses guidance documents that have been published by the FDA.

Contribution of economic evaluation to decision making in early phases of product development: a methodological and empirical review.

PubMed

Hartz, Susanne; John, Jürgen

2008-01-01

Economic evaluation as an integral part of health technology assessment is today mostly applied to established technologies. Evaluating healthcare innovations in their early states of development has recently attracted attention. Although it offers several benefits, it also holds methodological challenges. The aim of our study was to investigate the possible contributions of economic evaluation to industry's decision making early in product development and to confront the results with the actual use of early data in economic assessments. We conducted a literature research to detect methodological contributions as well as economic evaluations that used data from early phases of product development. Economic analysis can be beneficially used in early phases of product development for various purposes including early market assessment, R&D portfolio management, and first estimations of pricing and reimbursement scenarios. Analytical tools available for these purposes have been identified. Numerous empirical works were detected, but most do not disclose any concrete decision context and could not be directly matched with the suggested applications. Industry can benefit from starting economic evaluation early in product development in several ways. Empirical evidence suggests that there is still potential left unused.

Dynamics of the mental health workforce: investigating the composition of physicians and other health providers.

PubMed

Stefos, Theodore; Burgess, James F; Cohen, Jeffrey P; Lehner, Laura; Moran, Eileen

2012-12-01

We evaluate how changes to mental health workforce levels, composition, and degree of labor substitution, may impact typical practice output. Using a generalized Leontief production function and data from 134 U.S. Department of Veterans Affairs (VA) mental health practices, we estimate the q-complementarity/q-substitutability of mental health workers. We look at the entire spectrum of mental health services rather than just outpatient or physician office services. We also examine more labor types, including residents, than previous studies. The marginal patient care output contribution is estimated for each labor type as well as the degree to which physicians and other mental health workers may be substitutes or complements. Results indicate that numerous channels exist through which input substitution can improve productivity. Seven of eight labor and capital inputs have positive estimated marginal products. Most factor inputs exhibit diminishing marginal productivity. Of 28 unique labor-capital pairs, 17 are q-complements and 11 are q-substitutes. Complementarity among several labor types provides evidence of a team approach to mental health service provision. Our approach may serve to better inform healthcare providers regarding more productive mental health workforce composition both in and outside of VA.

Gene therapy for cancer: regulatory considerations for approval

PubMed Central

Husain, S R; Han, J; Au, P; Shannon, K; Puri, R K

2015-01-01

The rapidly changing field of gene therapy promises a number of innovative treatments for cancer patients. Advances in genetic modification of cancer and immune cells and the use of oncolytic viruses and bacteria have led to numerous clinical trials for cancer therapy, with several progressing to late-stage product development. At the time of this writing, no gene therapy product has been approved by the United States Food and Drug Administration (FDA). Some of the key scientific and regulatory issues include understanding of gene transfer vector biology, safety of vectors in vitro and in animal models, optimum gene transfer, long-term persistence or integration in the host, shedding of a virus and ability to maintain transgene expression in vivo for a desired period of time. Because of the biological complexity of these products, the FDA encourages a flexible, data-driven approach for preclinical safety testing programs. The clinical trial design should be based on the unique features of gene therapy products, and should ensure the safety of enrolled subjects. This article focuses on regulatory considerations for gene therapy product development and also discusses guidance documents that have been published by the FDA. PMID:26584531

When gluons go odd: how classical gluon fields generate odd azimuthal harmonics for the two-gluon correlation function in high-energy collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kovchegov, Yuri V.; Skokov, Vladimir V.

We show that, in the saturation/Color Glass Condensate framework, odd azimuthal harmonics of the two-gluon correlation function with a long-range separation in rapidity are generated by the higher-order saturation corrections in the interactions with the projectile and the target. At the very least, the odd harmonics require three scatterings in the projectile and three scatterings in the target. We derive the leading-order expression for the two-gluon production cross section which generates odd harmonics: the expression includes all-order interactions with the target and three interactions with the projectile. Here, we evaluate the obtained expression both analytically and numerically, confirming that themore » odd-harmonics contribution to the two-gluon production in the saturation framework is non-zero.« less

When gluons go odd: how classical gluon fields generate odd azimuthal harmonics for the two-gluon correlation function in high-energy collisions

DOE PAGES

Kovchegov, Yuri V.; Skokov, Vladimir V.

2018-04-30

We show that, in the saturation/Color Glass Condensate framework, odd azimuthal harmonics of the two-gluon correlation function with a long-range separation in rapidity are generated by the higher-order saturation corrections in the interactions with the projectile and the target. At the very least, the odd harmonics require three scatterings in the projectile and three scatterings in the target. We derive the leading-order expression for the two-gluon production cross section which generates odd harmonics: the expression includes all-order interactions with the target and three interactions with the projectile. Here, we evaluate the obtained expression both analytically and numerically, confirming that themore » odd-harmonics contribution to the two-gluon production in the saturation framework is non-zero.« less

Alkyl Glucosides in Contact Dermatitis.

PubMed

Loranger, Camille; Alfalah, Maisa; Ferrier Le Bouedec, Marie-Christine; Sasseville, Denis

Ecologically sound because they are synthesized from natural and renewable sources, the mild surfactants alkyl glucosides are being rediscovered by the cosmetic industry. They are currently found in rinse-off products such as shampoos, liquid cleansers, and shower gels, but also in leave-on products that include moisturizers, deodorants, and sunscreens. During the past 15 years, numerous cases of allergic contact dermatitis have been published, mostly to lauryl and decyl glucosides, and these compounds are considered emergent allergens. Interestingly, the sunscreen Tinosorb M contains decyl glucoside as a hidden allergen, and most cases of allergic contact dermatitis reported to this sunscreen ingredient are probably due to sensitization to decyl glucoside. This article will review the chemistry of alkyl glucosides, their sources of exposure, as well as their cutaneous adverse effects reported in the literature and encountered in various patch testing centers.

Probing Chemical Space with Alkaloid-Inspired Libraries

PubMed Central

McLeod, Michael C.; Singh, Gurpreet; Plampin, James N.; Rane, Digamber; Wang, Jenna L.; Day, Victor W.; Aubé, Jeffrey

2014-01-01

Screening of small molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries, due to their structural complexity and sp3-rich character. Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally related cyclindricine and lepadiformine families, lupin, and Amaryllidaceae). In each case, scaffolds were based on structures of the naturally occurring compounds or a close derivative. Scaffold preparation was pursued following the development of appropriate enabling chemical methods. Diversification provided 686 new compounds suitable for screening. The libraries thus prepared had structural characteristics, including sp3 content, comparable to a basis set of representative natural products and were highly rule-of-five compliant. PMID:24451589

Development and Characterization of Titanium Compound N anostructures

NASA Astrophysics Data System (ADS)

Zhou, Zhou

The development and characterization of titanium compound nanostructures have been achieved, for potential applications in energy industry. Oil and gas, one of the traditional industry fields, observes accumulating demands on active implementations of nanotechnology, for the numerous advantages that nanomaterials can introduce to both product performances and field operations. By using chemical vapor deposition and liquid exfoliation, various titanium compound nanostructures have been synthesized through this project. Attractively, these two material fabrication methods have been recognized to be industrial friendly in terms of cost efficiency and productivity. The development of nanostructures, aiming at oil and gas field applications, presents novel solutions for existing issues, such as low durability of drilling tools, high friction in mechanical operations and ineffective heat dissipation. Titanium compound nanostructures, including titanium borides, nitrides and sulfides are therefore investigated for such applications as protective coating, lubrication and thermal management.

Potential of Different Coleus blumei Tissues for Rosmarinic Acid Production

PubMed Central

Vuković, Rosemary; Likić, Saša; Jelaska, Sibila

2015-01-01

Summary Rosmarinic acid is one of the main active components of Coleus blumei and is known to have numerous health benefits. The pharmacological significance of rosmarinic acid and its production through in vitro culture has been the subject of numerous studies. Here, the ability of different tissues to accumulate rosmarinic acid and sustainability in production over long cultivation have been tested. Calli, tumours, normal roots and hairy roots were established routinely by application of plant growth regulators or by transformation with agrobacteria. The differences among the established tumour lines were highly heterogeneous. Hairy root lines showed the highest mean growth rate and consistency in rosmarinic acid production. Although some tumour lines produced more rosmarinic acid than the hairy root lines, over a long cultivation period their productivity was unstable and decreased. Further, the effects of plant growth regulators on growth and rosmarinic acid accumulation were tested. 2,4-Dichlorophenoxyacetic acid significantly reduced tumour growth and rosmarinic acid production. 1-Naphthaleneacetic acid strongly stimulated hairy root growth whilst abscisic acid strongly enhanced rosmarinic acid production. Hairy roots cultured in an airlift bioreactor exhibited the highest potential for mass production of rosmarinic acid. PMID:27904326

A theoretical study of concentration of profiles of primary cytochemical-enzyme reaction products in membrane-bound cell organelles and its application to lysosomal acid phosphatase.

PubMed

Cornelisse, C J; Hermens, W T; Joe, M T; Duijndam, W A; van Duijn, P

1976-11-01

A numerical method was developed for computing the steady-state concentration gradient of a diffusible enzyme reaction product in a membrane-limited compartment of a simplified theoretical cell model. In cytochemical enzyme reactions proceeding according to the metal-capture principle, the local concentration of the primary reaction product is an important factor in the onset of the precipitation process and in the distribution of the final reaction product. The following variables were incorporated into the model: enzyme activity, substrate concentration, Km, diffusion coefficient of substrate and product, particle radius and cell radius. The method was applied to lysosomal acid phosphatase. Numerical values for the variables were estimated from experimental data in the literature. The results show that the calculated phosphate concentrations inside lysosomes are several orders of magnitude lower than the critical concentrations for efficient phosphate capture found in a previous experimental model study. Reasons for this apparent discrepancy are discussed.

The analysis of bottom forming process for hybrid heating device

NASA Astrophysics Data System (ADS)

Bałon, Paweł; Świątoniowski, Andrzej; Kiełbasa, Bartłomiej

2017-10-01

In this paper the authors present an unusual method for bottom forming applicable for various industrial purposes including the manufacture of water heaters or pressure equipment. This method allows for the fabrication of the bottom of a given piece of stainless steel into a pre-determined shape conforming to the DIN standard which determines the most advantageous dimensions for the bottom cross section in terms of working pressure loading. The authors checked the validity of the method in a numerical and experimental way generating a tool designed to produce bottoms of specified geometry. Many problems are encountered during the design and production of parts, especially excessive sheet wrinkling over a large area of the part. The experiment showed that a lack of experience and numerical analysis in the design of such elements would result in the production of highly wrinkled parts. This defect would render the parts impossible to assemble with the cylindrical part. Many tool shops employ a method for drawing elements with a spherical surface which involves additional spinning, stamping, and grading operations, which greatly increases the cost of parts production. The authors present and compare two forming methods for spherical and parabolic objects, and experimentally confirm the validity of the sheet reversing method with adequate pressure force. The applied method produces parts in one drawing operation and in a following operation that is based on laser or water cutting to obtain a round blank. This reduces the costs of tooling manufacturing by requiring just one tool which can be placed on any hydraulic press with a minimum force of 2 000 kN.

Interactive numerals

PubMed Central

2017-01-01

Although Arabic numerals (like ‘2016’ and ‘3.14’) are ubiquitous, we show that in interactive computer applications they are often misleading and surprisingly unreliable. We introduce interactive numerals as a new concept and show, like Roman numerals and Arabic numerals, interactive numerals introduce another way of using and thinking about numbers. Properly understanding interactive numerals is essential for all computer applications that involve numerical data entered by users, including finance, medicine, aviation and science. PMID:28484609

Experimental and numerical researches of duplex burnishing process in aspect of achieved productive quality of the product

NASA Astrophysics Data System (ADS)

Patyk, Radoslaw; Kukielka, Leon; Kaldunski, Pawel; Bohdal, Lukasz; Chodor, Jaroslaw; Kulakowska, Agnieszka; Kukielka, Krzysztof; Nagnajewicz, Slawomir

2018-05-01

The paper presents the results of experimental researches and numerical simulations of the duplex burnishing process. During duplex burnishing process the treatment is carry out in two stages. In the first stage - on the semi-fabrication surface, the regular asperities are embossed with triangular, symmetrical, periodic outline. In the second stage the asperities are burnished (smooth burnishing) till the needed asperities equalized, resulting in a smooth and strengthened surface layer. The implementation of such technology results in receiving of a new surface layer characterized by favorable functional properties, particularly increased resistance to fatigue wear.

Entanglement dynamics in critical random quantum Ising chain with perturbations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Yichen, E-mail: ychuang@caltech.edu

We simulate the entanglement dynamics in a critical random quantum Ising chain with generic perturbations using the time-evolving block decimation algorithm. Starting from a product state, we observe super-logarithmic growth of entanglement entropy with time. The numerical result is consistent with the analytical prediction of Vosk and Altman using a real-space renormalization group technique. - Highlights: • We study the dynamical quantum phase transition between many-body localized phases. • We simulate the dynamics of a very long random spin chain with matrix product states. • We observe numerically super-logarithmic growth of entanglement entropy with time.

Modeling the Pathophysiology of Phonotraumatic Vocal Hyperfunction with a Triangular Glottal Model of the Vocal Folds

ERIC Educational Resources Information Center

Galindo, Gabriel E.; Peterson, Sean D.; Erath, Byron D.; Castro, Christian; Hillman, Robert E.; Zañartu, Matías

2017-01-01

Purpose: Our goal was to test prevailing assumptions about the underlying biomechanical and aeroacoustic mechanisms associated with phonotraumatic lesions of the vocal folds using a numerical lumped-element model of voice production. Method: A numerical model with a triangular glottis, posterior glottal opening, and arytenoid posturing is…

Approach to developing numeric water quality criteria for coastal waters: a transition from SeaWiFS to MODIS and MERIS satellites.

EPA Science Inventory

Human activities on land increase nutrient loads to coastal waters, which can increase phytoplankton production and biomass and potentially cause harmful ecological effects. States can adopt numeric water quality criteria into their water quality standards to protect the designa...

Semantic Processing in the Production of Numerals across Notations

ERIC Educational Resources Information Center

Herrera, Amparo; Macizo, Pedro

2012-01-01

In the present work, we conducted a series of experiments to explore the processing stages required to name numerals presented in different notations. To this end, we used the semantic blocking paradigm previously used in psycholinguist studies. We found a facilitative effect of the semantic blocked context relative to the mixed context for Arabic…

Prediction of the explosion effect of aluminized explosives

NASA Astrophysics Data System (ADS)

Zhang, Qi; Xiang, Cong; Liang, HuiMin

2013-05-01

We present an approach to predict the explosion load for aluminized explosives using a numerical calculation. A code to calculate the species of detonation products of high energy ingredients and those of the secondary reaction of aluminum and the detonation products, velocity of detonation, pressure, temperature and JWL parameters of aluminized explosives has been developed in this study. Through numerical calculations carried out with this code, the predicted JWL parameters for aluminized explosives have been compared with those measured by the cylinder test. The predicted JWL parameters with this code agree with those measured by the cylinder test. Furthermore, the load of explosion for the aluminized explosive was calculated using the numerical simulation by using the JWL equation of state. The loads of explosion for the aluminized explosive obtained using the predicted JWL parameters have been compared with those using the measured JWL parameters. Both of them are almost the same. The numerical results using the predicted JWL parameters show that the explosion air shock wave is the strongest when the mass fraction of aluminum powder in the explosive mixtures is 30%. This result agrees with the empirical data.

MADNESS: A Multiresolution, Adaptive Numerical Environment for Scientific Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrison, Robert J.; Beylkin, Gregory; Bischoff, Florian A.

2016-01-01

MADNESS (multiresolution adaptive numerical environment for scientific simulation) is a high-level software environment for solving integral and differential equations in many dimensions that uses adaptive and fast harmonic analysis methods with guaranteed precision based on multiresolution analysis and separated representations. Underpinning the numerical capabilities is a powerful petascale parallel programming environment that aims to increase both programmer productivity and code scalability. This paper describes the features and capabilities of MADNESS and briefly discusses some current applications in chemistry and several areas of physics.

Electron microscopy of vesicular-arbuscular mycorrhizae of yellow poplar. III Host-endophyte interactions during arbuscular development.

PubMed

Kinden, D A; Brown, M F

1975-12-01

Scanning- and transmission-electron microscopy were used to examine developing and mature functional arbuscules in mycorrhizal roots of yellow poplar. Arbuscules developed from intracellular hyphae which branched repeatedly upon penetration into the host cells. Intermediate and late stages of developemnt were characterized by the production of numerous, short, bifurcate hyphae throughout the arbuscule. Mature arbuscules exhibited a coralloid morphology which resulted in a considerable increase in the surface area of the endophyte exposed within the host cells. Distinctive ultrastructural features of arbuscular hyphae included osmiophilic walls, nuclei, abundant cytoplasm, glycogen, and numerous small vacuoles. All arbuscular components were enclosed by host wall material and cytoplasm during development and at maturity. In infected cells, host nuclei were enlarged and the cytoplasm associated with the arbuscular branches typically contained abundant mitochondria, endoplasmic reticulum, and proplastids. Ultrastructural observations suggested that nutrient transfer may be predominantly directed toward the fungal endophyte during arbuscular development and while mature arbuscules remain functional.

Integrated Hydrogeological Investigation on the Vulnerability of a Pumping Station at a Losing Stream

NASA Astrophysics Data System (ADS)

Ngueleu Kamangou, Stephane; Vogt, Tobias; Cirpka, Olaf

2010-05-01

River restoration usually includes alteration of the river channel morphology. Thereby the interaction between river and groundwater can be modified. For the design of a river restoration project - especially in the vicinity of a groundwater pumping well for drinking water production - this impact must be predicted. But a good prediction requires a proper understanding of the existing situation. Numerical models help to improve the strategy of a successful river restoration project. The main objective of this study was to investigate the vulnerability of a pumping station located at losing river in northeast Switzerland. Besides the effect that river restoration could create, a particular attention was placed on the effect of a beaver dam in a side channel close to the pumping station. Analysis of field measurements coupled with numerical modeling of the pumping station area improved the understanding of the interactions in the river corridor between the river, side channels and the alluvial aquifer.

Optimization of Antitumor Modulators of Pre-mRNA Splicing

PubMed Central

Lagisetti, Chandraiah; Palacios, Gustavo; Goronga, Tinopiwa; Freeman, Burgess; Caufield, William; Webb, Thomas R.

2014-01-01

The spliceosome regulates pre-mRNA splicing, which is a critical process in normal mammalian cells. Recently recurrent mutations in numerous spliceosomal proteins have been associated with a number of cancers. Previously natural product antitumor agents have been shown to interact with one of the proteins that is subject to recurrent mutations (SF3B1). We report the optimization of a class of tumor-selective spliceosome modulators, which demonstrate significant in vivo antitumor activity. This optimization culminated in the discovery of sudemycin D6, which shows potent cytotoxic activity in the melanoma line SK-MEL-2 (IC50= 39 nM) and other tumor lines, including: JeKo-1 (IC50= 26 nM), HeLa (IC50= 50 nM), and SK-N-AS (IC50= 81 nM). We also report improved processes for the synthesis of these compounds. Our work supports the idea that sudemycin D6 is worthy of further investigation as a novel preclinical anticancer agent with application in the treatment of numerous human cancers. PMID:24325474

Simulations of incompressible Navier Stokes equations on curved surfaces using discrete exterior calculus

NASA Astrophysics Data System (ADS)

Samtaney, Ravi; Mohamed, Mamdouh; Hirani, Anil

2015-11-01

We present examples of numerical solutions of incompressible flow on 2D curved domains. The Navier-Stokes equations are first rewritten using the exterior calculus notation, replacing vector calculus differential operators by the exterior derivative, Hodge star and wedge product operators. A conservative discretization of Navier-Stokes equations on simplicial meshes is developed based on discrete exterior calculus (DEC). The discretization is then carried out by substituting the corresponding discrete operators based on the DEC framework. By construction, the method is conservative in that both the discrete divergence and circulation are conserved up to machine precision. The relative error in kinetic energy for inviscid flow test cases converges in a second order fashion with both the mesh size and the time step. Numerical examples include Taylor vortices on a sphere, Stuart vortices on a sphere, and flow past a cylinder on domains with varying curvature. Supported by the KAUST Office of Competitive Research Funds under Award No. URF/1/1401-01.

Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?

PubMed Central

Steinfelder, Svenja; O’Regan, Noëlle Louise; Hartmann, Susanne

2016-01-01

Helminths have evolved numerous pathways to prevent their expulsion or elimination from the host to ensure long-term survival. During infection, they target numerous host cells, including macrophages, to induce an alternatively activated phenotype, which aids elimination of infection, tissue repair, and wound healing. Multiple animal-based studies have demonstrated a significant reduction or complete reversal of disease by helminth infection, treatment with helminth products, or helminth-modulated macrophages in models of allergy, autoimmunity, and sepsis. Experimental studies of macrophage and helminth therapies are being translated into clinical benefits for patients undergoing transplantation and those with multiple sclerosis. Thus, helminths or helminth-modulated macrophages present great possibilities as therapeutic applications for inflammatory diseases in humans. Macrophage-based helminth therapies and the underlying mechanisms of their therapeutic or curative effects represent an under-researched area with the potential to open new avenues of treatment. This review explores the application of helminth-modulated macrophages as a new therapy for inflammatory diseases. PMID:27101372

Extraction and isolation of catechins from tea.

PubMed

Vuong, Quan V; Golding, John B; Nguyen, Minh; Roach, Paul D

2010-11-01

Tea is a major source of catechins, which have become well known for their antioxidant potential. Numerous human, animal, and in vitro studies have linked tea catechins with prevention of certain types of cancers, reduction of the risks for obesity, diabetes, and cardiovascular disease, and improvement of the immune system. Tea catechins are widely used in various neutraceuticals, pharmaceuticals, and cosmetics for either enhancing product shelf-life or for enhancing human health. Thus, the demand for catechins has increased considerably. Catechins have been extracted and isolated from tea leaves by numerous methods through several steps including: treatment of the tea leaves, extraction of catechins from teas into solvents, isolation of catechins from other extracted components, and drying the preparations to obtain catechin extracts in a powder form. This paper outlines the physical and chemical properties of the tea catechins and reviews the extraction steps of the various extraction methods, as a basis to improve and further develop the extraction and isolation of the tea catechins.

Sedimentary Geothermal Feasibility Study: October 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Augustine, Chad; Zerpa, Luis

The objective of this project is to analyze the feasibility of commercial geothermal projects using numerical reservoir simulation, considering a sedimentary reservoir with low permeability that requires productivity enhancement. A commercial thermal reservoir simulator (STARS, from Computer Modeling Group, CMG) is used in this work for numerical modeling. In the first stage of this project (FY14), a hypothetical numerical reservoir model was developed, and validated against an analytical solution. The following model parameters were considered to obtain an acceptable match between the numerical and analytical solutions: grid block size, time step and reservoir areal dimensions; the latter related to boundarymore » effects on the numerical solution. Systematic model runs showed that insufficient grid sizing generates numerical dispersion that causes the numerical model to underestimate the thermal breakthrough time compared to the analytic model. As grid sizing is decreased, the model results converge on a solution. Likewise, insufficient reservoir model area introduces boundary effects in the numerical solution that cause the model results to differ from the analytical solution.« less

Numerical Boundary Condition Procedures

NASA Technical Reports Server (NTRS)

1981-01-01

Topics include numerical procedures for treating inflow and outflow boundaries, steady and unsteady discontinuous surfaces, far field boundaries, and multiblock grids. In addition, the effects of numerical boundary approximations on stability, accuracy, and convergence rate of the numerical solution are discussed.

Comparison of fetal testosterone production in various tissues of the male sprague dawley rat dosed in utero with dipentyl phthalate during the critical window of sexual differentiation

EPA Science Inventory

Phthalate esters are high-production volume chemicals used in the manufacture of numerous plastics and consumer products, which generates major concern for potential human exposure and environmental contamination. Several studies have demonstrated adverse effects associated with ...

Estimating production and consumption of solid reactive Fe phases in marine sediments from concentration profiles

EPA Science Inventory

1D diffusion models may be used to estimate rates of production and consumption of dissolved metabolites in marine sediments, but are applied less often to the solid phase. Here we used a numerical inverse method to estimate solid phase Fe(III) and Fe(II) consumption and product...

Evaluating Evidence for Ed-Tech Product Effectiveness: Guidelines for School Districts

ERIC Educational Resources Information Center

Center for Research and Reform in Education, 2017

2017-01-01

Educational technology products offer potentially effective means of supporting teaching and learning in K-12 classrooms. But for any given instructional need, there are likely to be numerous product options available for purchasing. What can school districts do to help ensure that good selections are made? In a recent, comprehensive study of…

Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture

EPA Science Inventory

The chlorination of drinking water results in production of numerous disinfection by-products (DBPs). One of the important classes of DBPs is the haloacetic acids. We have previously shown that the haloacetic acids (HAs), dichloro (DCA), dibromo (DBA) and bromochloro (BCA) acetic...

Hydraulic fracture conductivity: effects of rod-shaped proppant from lattice-Boltzmann simulations and lab tests

NASA Astrophysics Data System (ADS)

Osiptsov, Andrei A.

2017-06-01

The goal of this study is to evaluate the conductivity of random close packings of non-spherical, rod-shaped proppant particles under the closure stress using numerical simulation and lab tests, with application to the conductivity of hydraulic fractures created in subterranean formation to stimulate production from oil and gas reservoirs. Numerical simulations of a steady viscous flow through proppant packs are carried out using the lattice Boltzmann method for the Darcy flow regime. The particle packings were generated numerically using the sequential deposition method. The simulations are conducted for packings of spheres, ellipsoids, cylinders, and mixtures of spheres with cylinders at various volumetric concentrations. It is demonstrated that cylinders provide the highest permeability among the proppants studied. The dependence of the nondimensional permeability (scaled by the equivalent particle radius squared) on porosity obtained numerically is well approximated by the power-law function: K /Rv2 = 0.204ϕ4.58 in a wide range of porosity: 0.3 ≤ ϕ ≤ 0.7. Lattice-Boltzmann simulations are cross-verified against finite-volume simulations using Navier-Stokes equations for inertial flow regime. Correlations for the normalized beta-factor as a function of porosity and normalized permeability are presented as well. These formulae are in a good agreement with the experimental measurements (including packings of rod-shaped particles) and existing laboratory data, available in the porosity range 0.3 ≤ ϕ ≤ 0.5. Comparison with correlations by other authors is also given.

Chemometric analysis of minerals in gluten-free products.

PubMed

Gliszczyńska-Świgło, Anna; Klimczak, Inga; Rybicka, Iga

2018-06-01

Numerous studies indicate mineral deficiencies in people on a gluten-free (GF) diet. These deficiencies may indicate that GF products are a less valuable source of minerals than gluten-containing products. In the study, the nutritional quality of 50 GF products is discussed taking into account the nutritional requirements for minerals expressed as percentage of recommended daily allowance (%RDA) or percentage of adequate intake (%AI) for a model celiac patient. Elements analyzed were calcium, potassium, magnesium, sodium, copper, iron, manganese, and zinc. Analysis of %RDA or %AI was performed using principal component analysis (PCA) and hierarchical cluster analysis (HCA). Using PCA, the differentiation between products based on rice, corn, potato, GF wheat starch and based on buckwheat, chickpea, millet, oats, amaranth, teff, quinoa, chestnut, and acorn was possible. In the HCA, four clusters were created. The main criterion determining the adherence of the sample to the cluster was the content of all minerals included to HCA (K, Mg, Cu, Fe, Mn); however, only the Mn content differentiated four formed groups. GF products made of buckwheat, chickpea, millet, oats, amaranth, teff, quinoa, chestnut, and acorn are better source of minerals than based on other GF raw materials, what was confirmed by PCA and HCA. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.