West Virginia Kids Count Data Book: 1993 County Profiles of Child Well-Being.

ERIC Educational Resources Information Center

West Virginia Task Force on Children, Youth and Families, Charleston.

This report provides information on 12 indicators of child and adolescent health, education, and economic status in West Virginia at the state and county level. It includes a state profile, a minority profile, and 55 county profiles. Each of the indicators is discussed on a state-wide basis. The bulk of the report consists of one-page county…

g:Profiler-a web server for functional interpretation of gene lists (2016 update).

PubMed

Reimand, Jüri; Arak, Tambet; Adler, Priit; Kolberg, Liis; Reisberg, Sulev; Peterson, Hedi; Vilo, Jaak

2016-07-08

Functional enrichment analysis is a key step in interpreting gene lists discovered in diverse high-throughput experiments. g:Profiler studies flat and ranked gene lists and finds statistically significant Gene Ontology terms, pathways and other gene function related terms. Translation of hundreds of gene identifiers is another core feature of g:Profiler. Since its first publication in 2007, our web server has become a popular tool of choice among basic and translational researchers. Timeliness is a major advantage of g:Profiler as genome and pathway information is synchronized with the Ensembl database in quarterly updates. g:Profiler supports 213 species including mammals and other vertebrates, plants, insects and fungi. The 2016 update of g:Profiler introduces several novel features. We have added further functional datasets to interpret gene lists, including transcription factor binding site predictions, Mendelian disease annotations, information about protein expression and complexes and gene mappings of human genetic polymorphisms. Besides the interactive web interface, g:Profiler can be accessed in computational pipelines using our R package, Python interface and BioJS component. g:Profiler is freely available at http://biit.cs.ut.ee/gprofiler/. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

How safe do teenagers behave on Facebook? An observational study.

PubMed

Vanderhoven, Ellen; Schellens, Tammy; Valcke, Martin; Raes, Annelies

2014-01-01

The substantial use of social network sites by teenagers has raised concerns about privacy and security. Previous research about behavior on social network sites was mostly based on surveys and interviews. Observational research overcomes problems inherent to this research method, for example social desirability. However, existing observational research mostly focuses on public profiles of young adults. Therefore, the current observation-study includes 1050 public and non-public Facebook-profiles of teenagers (13-18) to investigate (1) what kind of information teenagers post on their profile, (2) to what extent they protect this information using privacy-settings and (3) how much risky information they have on their profile. It was found that young people mostly post pictures, interests and some basic personal information on their profile. Some of them manage their privacy-settings as such that this information is reserved for friends' eyes only, but a lot of information is accessible on the friends-of-friends' pages. Although general risk scores are rather low, more detailed analyses show that teenagers nevertheless post a significant amount of risky information. Moreover, older teenagers and girls post more (risky) information while there are no differences in applying privacy settings. We found no differences in the Facebook behavior of teenagers enrolled in different education forms. Implications of these results are discussed.

How Safe Do Teenagers Behave on Facebook? An Observational Study

PubMed Central

Vanderhoven, Ellen; Schellens, Tammy; Valcke, Martin; Raes, Annelies

2014-01-01

The substantial use of social network sites by teenagers has raised concerns about privacy and security. Previous research about behavior on social network sites was mostly based on surveys and interviews. Observational research overcomes problems inherent to this research method, for example social desirability. However, existing observational research mostly focuses on public profiles of young adults. Therefore, the current observation-study includes 1050 public and non-public Facebook-profiles of teenagers (13–18) to investigate (1) what kind of information teenagers post on their profile, (2) to what extent they protect this information using privacy-settings and (3) how much risky information they have on their profile. It was found that young people mostly post pictures, interests and some basic personal information on their profile. Some of them manage their privacy-settings as such that this information is reserved for friends' eyes only, but a lot of information is accessible on the friends-of-friends' pages. Although general risk scores are rather low, more detailed analyses show that teenagers nevertheless post a significant amount of risky information. Moreover, older teenagers and girls post more (risky) information while there are no differences in applying privacy settings. We found no differences in the Facebook behavior of teenagers enrolled in different education forms. Implications of these results are discussed. PMID:25162234

West Virginia Kids Count Data Book: 1994 County Profiles of Child Well-Being.

ERIC Educational Resources Information Center

West Virginia Task Force on Children, Youth and Families, Charleston.

This report provides information on 12 indicators of child and adolescent health, education, and economic status in West Virginia at the state and county level. The report includes a state profile, a minority profile, and 55 county profiles. Each of the indicators is discussed on a state-wide basis. The bulk of the report consists of 1-page county…

Colorado Qualistar. QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Colorado's Qualistar prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for Family…

Pennsylvania Keystone STARS: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Pennsylvania's Keystone STARS prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

Virginia Star Quality Initiative: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Virginia's Star Quality Initiative prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators…

Illinois Quality Counts: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Illinois' Quality Counts prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for Family…

Mississippi Quality Step System: QRS Profile. The Child Care Quality Rating System (QRS)Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Mississippi's Quality Step System prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Application…

Minnesota Parent Aware: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Minnesota's Parent Aware prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for Family…

Examination of social networking professionalism among dental and dental hygiene students.

PubMed

Henry, Rachel K; Molnar, Amy L

2013-11-01

Becoming a dental professional requires one to apply ethical decision making skills and demonstrate high standards of professionalism in practice, including the way professionals present themselves to the public. With social media as an evergrowing part of personal and professional communications, this study aimed to determine the accessibility, amount, and type of unprofessional content on Facebook profiles of dental hygiene and dental students in a college of dentistry. The authors evaluated the online profiles of all 499 dental and dental hygiene students at The Ohio State University using objective measures that included existence of a profile, current privacy settings, and access to personally identifiable information. A sample of profiles were evaluated for unprofessional content including photos, comments, and wall posts. The majority of these students were found to use Facebook, with 61 percent having Facebook profiles. Dental hygiene students were more likely to have a Facebook profile than were dental students: 72.6 percent and 59.1 percent, respectively (p=0.027). The majority of the students' profiles had some form of privacy setting enabled, with only 4 percent being entirely open to the public. Fewer than 2 percent of the students allowed non-friends access to personal information. Based on in-depth analysis of the profiles, fourteen (5.8 percent) instances of unprofessionalism were recorded; the most common unprofessional content involved substance abuse. This study found that these dental and dental hygiene students frequently possessed an identifiable Facebook account and nearly half had some kind of personal information on their profile that could potentially be shared with the public. In some instances, the students gave patients, faculty, and potential employers access to content that is not reflective of a dental professional. Academic institutions should consider implementing policies that bring awareness to and address the use of social media in a professional environment.

World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA. [Brief tabulated information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then bymore » facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.« less

Delaware Stars for Early Success. QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Delaware's Stars for Early Success prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators…

Palm Beach Quality Counts: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Palm Beach's Quality Counts prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

Tennessee Star-Quality Child Care Program: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Tennessee's Star-Quality Child Care Program prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

Maine Quality for ME: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Maine's Quality for ME prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for Family…

Vermont STep Ahead Recognition System: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Vermont's STep Ahead Recognition System (STARS) prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for All Child Care Programs;…

Missouri Quality Rating System: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Missouri's Quality Rating System prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

Ohio Step Up to Quality: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Ohio's Step Up to Quality prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for Family…

Miami-Dade Quality Counts: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Miami-Dade's Quality Counts prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

Kentucky STARS for KIDS NOW: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Kentucky's STARS for KIDS NOW prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

Indiana Paths to Quality: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Indiana's Paths to Quality prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4) Indicators for…

North Carolina Star Rated License System: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of North Carolina's Star Rated License System prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

Oregon Child Care Quality Indicators Program: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Oregon's Child Care Quality Indicators Program prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

New Hampshire Quality Rating System: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of New Hampshire's Quality Rating System prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

Curriculum Profiles: A Resource of the EDC K-12 Science Curriculum Dissemination Center

ERIC Educational Resources Information Center

Education Development Center, Inc, 2005

2005-01-01

The purpose of this document is to provide useful information for teachers and school systems engaged in the process of examining and choosing science curriculum materials appropriate for their settings. The curriculum profiles include summaries of selected programs available for K?12 science curriculum programs. Each profile describes a number of…

Definition of an ISO 19115 metadata profile for SeaDataNet II Cruise Summary Reports and its XML encoding

NASA Astrophysics Data System (ADS)

Boldrini, Enrico; Schaap, Dick M. A.; Nativi, Stefano

2013-04-01

SeaDataNet implements a distributed pan-European infrastructure for Ocean and Marine Data Management whose nodes are maintained by 40 national oceanographic and marine data centers from 35 countries riparian to all European seas. A unique portal makes possible distributed discovery, visualization and access of the available sea data across all the member nodes. Geographic metadata play an important role in such an infrastructure, enabling an efficient documentation and discovery of the resources of interest. In particular: - Common Data Index (CDI) metadata describe the sea datasets, including identification information (e.g. product title, interested area), evaluation information (e.g. data resolution, constraints) and distribution information (e.g. download endpoint, download protocol); - Cruise Summary Reports (CSR) metadata describe cruises and field experiments at sea, including identification information (e.g. cruise title, name of the ship), acquisition information (e.g. utilized instruments, number of samples taken) In the context of the second phase of SeaDataNet (SeaDataNet 2 EU FP7 project, grant agreement 283607, started on October 1st, 2011 for a duration of 4 years) a major target is the setting, adoption and promotion of common international standards, to the benefit of outreach and interoperability with the international initiatives and communities (e.g. OGC, INSPIRE, GEOSS, …). A standardization effort conducted by CNR with the support of MARIS, IFREMER, STFC, BODC and ENEA has led to the creation of a ISO 19115 metadata profile of CDI and its XML encoding based on ISO 19139. The CDI profile is now in its stable version and it's being implemented and adopted by the SeaDataNet community tools and software. The effort has then continued to produce an ISO based metadata model and its XML encoding also for CSR. The metadata elements included in the CSR profile belong to different models: - ISO 19115: E.g. cruise identification information, including title and area of interest; metadata responsible party information - ISO 19115-2: E.g. acquisition information, including date of sampling, instruments used - SeaDataNet: E.g. SeaDataNet community specific, including EDMO and EDMERP code lists Two main guidelines have been followed in the metadata model drafting: - All the obligations and constraints required by both the ISO standards and INSPIRE directive had to be satisfied. These include the presence of specific elements with given cardinality (e.g. mandatory metadata date stamp, mandatory lineage information) - All the content information of legacy CSR format had to be supported by the new metadata model. An XML encoding of the CSR profile has been defined as well. Based on the ISO 19139 XML schema and constraints, it adds the new elements specific of the SeaDataNet community. The associated Schematron rules are used to enforce constraints not enforceable just with the Schema and to validate elements content against the SeaDataNet code lists vocabularies.

76 FR 67454 - Agency Information Collection Request; 30-Day Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-01

... revising the collection to include changes adopted by the cross-agency R&R working group. This working... Assistance (Cover); R&R Personal Data; R&R Senior/Key Person Profile; R&R Senior/Key Person Profile (Expanded...

Near-Inertial and Tidal Currents Detected with a Vessel Mounted Acoustic Doppler Current Profiler in the Western Mediterranean Sea

NASA Technical Reports Server (NTRS)

Garcia-Gorriz, E.; Candela, J.; Font, J.

1998-01-01

The Acoustic Doppler Current Profiler (ADCP) combined with accurate navigation provides absolute current velocities which include information from all the frequencies which have a dynamical presence in the ocean.

Louisiana Quality Start Child Care Rating System: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Louisiana's Quality Start Child Care Rating System prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs;…

New Mexico Look for the STARS--AIM HIGH: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of New Mexico's Look for the STARS--AIM HIGH prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

Los Angeles County Steps to Excellence Project: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of Los Angeles County's Steps to Excellence Project prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs;…

Mars Sample Return: The Value of Depth Profiles

NASA Technical Reports Server (NTRS)

Hausrath, E. M.; Navarre-Sitchler, A. K.; Moore, J.; Sak, P. B.; Brantley, S. L.; Golden, D. C.; Sutter, B.; Schroeder, C.; Socki, R.; Morris, R. V.;

Looking Inside Schools of Choice: Eight Portraits.

ERIC Educational Resources Information Center

Clinchy, Evans

1986-01-01

Presents profiles of eight Massachusetts magnet schools: Nathan Hale (Boston); Burncoat Preparatory (Worcester); Rafael Hernandez (Boston); Mill Swan Communications Skill Center (Worcester); Sumner Avenue (Springfield); Arts (Lowell); Graham and Parks Alternative (Cambridge); and City (Lowell). Each profile includes information on school size and…

The Automation Inventory of Research Libraries, 1989.

ERIC Educational Resources Information Center

Fayen, Emily Gallup

This inventory provides profiles, tables, and listings describing automated library activities at 103 Association of Research Libraries (ARL) institutions. The inventory includes analyses of aggregate information from individual library profiles which are then divided into three categories that reflect primarily bibliographic functions: (1)…

The ecology of hydric hammocks: a community profile

USGS Publications Warehouse

Vince, Susan W.; Humphrey, Stephen R.; Simons, Robert W.

1989-01-01

This community profile is one in a series of Fish and Wildlife Service publications compiled to provide a state-of-knowledge synthesis of scientific information and literature on various coastal habitats. The subject of this profile is the hydric hammock, a distinctive type of forested wetland occurring at low elevations along the gulf coast of Florida from Aripeka to St. Marks and at various inland sites in Florida. Relatively little research has been conducted in hydric hammocks, and no thorough effort has been made previously to define this community. Consequently, no consensus has existed about the extent and nature of this community; some published works and active researchers have differed in their judgments about it; and the entity sometimes is ignored and often is lumped with other types of mixed hardwood forests. The purpose of this profile is to establish or clarify an identification and understanding of the hydric-hammock community. Information for the profile was gathered from published and unpublished literature, from persona 1 communication with many technical experts, and from our own fie 1 d experience. The profile includes some new data gathered in the field for the purpose of defining this community. It is hoped that the content and format of the profile will be useful to a broad spectrum of users, including other scientists, students, resource managers and planners, teachers, and interested citizens. The profile includes structural and functional aspects of the community: its physical setting, plant and animal composition and dynamics, interactions of its flora and fauna, and its relationships with other communities.

Profiling Fast Healthcare Interoperability Resources (FHIR) of Family Health History based on the Clinical Element Models.

PubMed

Lee, Jaehoon; Hulse, Nathan C; Wood, Grant M; Oniki, Thomas A; Huff, Stanley M

2016-01-01

In this study we developed a Fast Healthcare Interoperability Resources (FHIR) profile to support exchanging a full pedigree based family health history (FHH) information across multiple systems and applications used by clinicians, patients, and researchers. We used previously developed clinical element models (CEMs) that are capable of representing the FHH information, and derived essential data elements including attributes, constraints, and value sets. We analyzed gaps between the FHH CEM elements and existing FHIR resources. Based on the analysis, we developed a profile that consists of 1) FHIR resources for essential FHH data elements, 2) extensions for additional elements that were not covered by the resources, and 3) a structured definition to integrate patient and family member information in a FHIR message. We implemented the profile using an open-source based FHIR framework and validated it using patient-entered FHH data that was captured through a locally developed FHH tool.

Effective Chapter 1 Programs in Oregon.

ERIC Educational Resources Information Center

Berrum, Phyllis

This report describes 11 effective compensatory education programs in Oregon schools funded under Chapter 1 of the Education Consolidation and Improvement Act. One high school, four middle school, and six elementary school programs are profiled. Each profile includes the following information: (1) demographics; (2) staffing; (3) parent…

A profile of inactive information seekers on influenza prevention: a survey of health care workers in Central Kentucky.

PubMed

Kim, Sujin; Real, Kevin

2016-09-01

This study developed a profile of inactive information seekers by characterising how they are different from active seekers, identifying possible determinants of inactive seekers and understanding characteristics of frequently asked influenza-related questions. A survey and follow-up interviews were conducted between December 2010 and January 2011. A total of 307 health care workers in three hospitals in Central Kentucky (USA) are included. Four study groups were formed based on their information-seeking and vaccination uptake status: (1) Inactive Seekers with Vaccination (N = 141); (2) Inactive Seekers without Vaccination (N = 49); (3) Active Seekers with Vaccination (N = 107); and (4) Active Seekers without Vaccination (N = 10). Inactive Seekers without Vaccination are found to be least responsive to health outcomes. Inactive Seeker groups do not prefer to use sources such as Internet or family/friends. In predicting inactive seekers, Information Needs and Knowledge Perception made significant contributions to prediction. The most frequently asked questions included information about survival duration of influenza virus (N = 25) followed by the incubation period for influenza (N = 24). Profiling inactive seekers can serve as a way to better design customised influenza information sources and services for health care workers, thus giving hospitals through medical libraries additional tools to reduce the spread of influenza. © 2016 Health Libraries Group.

Cybersecurity Assessment Parameter Profile (CAPP). A Tool for Making Sense of Cybersecurity Assessments

DTIC Science & Technology

2018-03-28

completing and reviewing this collection of information . Send comments regarding this burden estimate or any other aspect of this collection of... information , including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling

PubMed Central

Wagner, Bridget K.; Clemons, Paul A.

2009-01-01

Discovering small-molecule modulators for thousands of gene products requires multiple stages of biological testing, specificity evaluation, and chemical optimization. Many cellular profiling methods, including cellular sensitivity, gene-expression, and cellular imaging, have emerged as methods to assess the functional consequences of biological perturbations. Cellular profiling methods applied to small-molecule science provide opportunities to use complex phenotypic information to prioritize and optimize small-molecule structures simultaneously against multiple biological endpoints. As throughput increases and cost decreases for such technologies, we see an emerging paradigm of using more information earlier in probe- and drug-discovery efforts. Moreover, increasing access to public datasets makes possible the construction of “virtual” profiles of small-molecule performance, even when multiplexed measurements were not performed or when multidimensional profiling was not the original intent. We review some key conceptual advances in small-molecule phenotypic profiling, emphasizing connections to other information, such as protein-binding measurements, genetic perturbations, and cell states. We argue that to maximally leverage these measurements in probe and drug discovery requires a fundamental connection to synthetic chemistry, allowing the consequences of synthetic decisions to be described in terms of changes in small-molecule profiles. Mining such data in the context of chemical structure and synthesis strategies can inform decisions about chemistry procurement and library development, leading to optimal small-molecule screening collections. PMID:19825513

Country analysis briefs: 1994. Profiles of major world energy producers, consumers, and transport centers

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-01

Country Analysis Briefs: 1994 is a compilation of country profiles prepared by the Energy Markets and Contingency Information Division (EMCID) of the Office of Energy Markets and End Use. EMCID maintains Country Analysis Briefs (CABs) for specific countries or geographical areas that are important to world energy markets. As a general rule, CABs are prepared for all members of the Organization of Petroleum Exporting Countries (OPEC), major non-OPEC oil producers (i.e., the North Sea, Russia), major energy transit areas (i.e., Ukraine), and other areas of current interest to energy analysts and policy makers. As of January 1995, EMCID maintained overmore » 40 CABs, updated on an annual schedule and subject to revision as events warrant. This report includes 25 CABs updated during 1994. All CABs contain a profile section, a map showing the country`s location, and a narrative section. The profile section includes outlines of the country`s economy, energy sector, and environment. The narrative provides further information and discussion of these topics. Some CABs also include a detailed map displaying locations of major oil and gas fields, pipelines, ports, etc. These maps were created as a result of special individual requests and so are not typically a standard feature of the CABs. They are presented here wherever available as a supplement to the information contained in the CABs.« less

District of Columbia Going for the Gold Tiered Rate Reimbursement System. QRS Profile. The Child Care Quality Rating System (QRS) Assessment

ERIC Educational Resources Information Center

Child Trends, 2010

2010-01-01

This paper presents a profile of District of Columbia's Going for the Gold Tiered Rate Reimbursement Systemp repared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for…

Simulation-based Bayesian inference for latent traits of item response models: Introduction to the ltbayes package for R.

PubMed

Johnson, Timothy R; Kuhn, Kristine M

2015-12-01

This paper introduces the ltbayes package for R. This package includes a suite of functions for investigating the posterior distribution of latent traits of item response models. These include functions for simulating realizations from the posterior distribution, profiling the posterior density or likelihood function, calculation of posterior modes or means, Fisher information functions and observed information, and profile likelihood confidence intervals. Inferences can be based on individual response patterns or sets of response patterns such as sum scores. Functions are included for several common binary and polytomous item response models, but the package can also be used with user-specified models. This paper introduces some background and motivation for the package, and includes several detailed examples of its use.

Profiles of Nine Community Colleges with Successful Foundations.

ERIC Educational Resources Information Center

Angel, Dan; Gares, Dale

1981-01-01

College profiles include the following information: type of college, location, enrollment, age of college, total budget, foundation's years of experience, non-profit status, total foundation assets, dollar support for 1979-80, responsibility for foundation, number of foundation board members, most successful fund-raising methods, and restrictions…

MO-AB-204-03: Profile Development and IHE Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pauer, C.

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

Drilling, logging, and testing information from borehole UE-25 UZ{number_sign}16, Yucca Mountain, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thamir, F.; Thordarson, W.; Kume, J.

Borehole UE-25 UZ{number_sign}16 is the first of two boreholes that may be used to determine the subsurface structure at Yucca Mountain by using vertical seismic profiling. This report contains information collected while this borehole was being drilled, logged, and tested from May 27, 1992, to April 22, 1994. It does not contain the vertical seismic profiling data. This report is intended to be used as: (1) a reference for drilling similar boreholes in the same area, (2) a data source on this borehole, and (3) a reference for other information that is available from this borehole. The reference information includesmore » drilling chronology, equipment, parameters, coring methods, penetration rates, completion information, drilling problems, and corrective actions. The data sources include lithology, fracture logs, a list of available borehole logs, and depths at which water was recorded. Other information is listed in an appendix that includes studies done after April 22, 1994.« less

Culinary Arts Profile.

ERIC Educational Resources Information Center

Missouri Univ., Columbia. Instructional Materials Lab.

This chart is intended for use in documenting the fact that a student participating in a culinary arts program has achieved the performance standards specified in the Missouri Competency Profile for culinary arts. The chart includes space for recording basic student and instructor information and the student's on-the-job training and work…

Profile of the International Work of Canadian Universities=Profil de la collaboration internationale des universites Canadiennes.

ERIC Educational Resources Information Center

Goldstone, Jennifer, Ed.; Gibbs, Darlene, Ed.

This directory describes international cooperation programs at 66 Canadian colleges and universities. Listed alphabetically, each institution briefly summarizes its international initiatives, provides information on the history and administrative structure of the international activities, includes a list of programs, and provides contact…

Adolescents' Online Social Networking Following the Death of a Peer

ERIC Educational Resources Information Center

Williams, Amanda L.; Merten, Michael J.

2009-01-01

The purpose of this study was to examine how online social networking facilitates adolescent grieving following the sudden death of a peer. Researchers reviewed 20 profiles authored by adolescents who had died between 2005 and 2007 collecting information from commentary posted to the profiles posthumously. Observed themes included adolescent…

ToxPi Prioritization and Profiling of 1060 ToxCast Chemicals Across Multiple Sectors of Toxicological Concern

EPA Science Inventory

The Toxicological Prioritization Index (ToxPi™) framework was developed as a decision-support tool to aid in the prioritization of chemicals for integrated toxicity testing. ToxPi consolidates information from multiple domains - including ToxCast™ in vitro bioactivity profiles (a...

A data types profile suitable for use with ISO EN 13606.

PubMed

Sun, Shanghua; Austin, Tony; Kalra, Dipak

2012-12-01

ISO EN 13606 is a five part International Standard specifying how Electronic Healthcare Record (EHR) information should be communicated between different EHR systems and repositories. Part 1 of the standard defines an information model for representing the EHR information itself, including the representation of types of data value. A later International Standard, ISO 21090:2010, defines a comprehensive set of models for data types needed by all health IT systems. This latter standard is vast, and duplicates some of the functions already handled by ISO EN 13606 part 1. A profile (sub-set) of ISO 21090 would therefore be expected to provide EHR system vendors with a more specially tailored set of data types to implement and avoid the risk of providing more than one modelling option for representing the information properties. This paper describes the process and design decisions made for developing a data types profile for EHR interoperability.

Recommending personally interested contents by text mining, filtering, and interfaces

DOEpatents

Xu, Songhua

2015-10-27

A personalized content recommendation system includes a client interface device configured to monitor a user's information data stream. A collaborative filter remote from the client interface device generates automated predictions about the interests of the user. A database server stores personal behavioral profiles and user's preferences based on a plurality of monitored past behaviors and an output of the collaborative user personal interest inference engine. A programmed personal content recommendation server filters items in an incoming information stream with the personal behavioral profile and identifies only those items of the incoming information stream that substantially matches the personal behavioral profile. The identified personally relevant content is then recommended to the user following some priority that may consider the similarity between the personal interest matches, the context of the user information consumption behaviors that may be shown by the user's content consumption mode.

Revisiting Social Network Utilization by Physicians-in-Training.

PubMed

Black, Erik W; Thompson, Lindsay A; Duff, W Patrick; Dawson, Kara; Saliba, Heidi; Black, Nicole M Paradise

2010-06-01

To measure and compare the frequency and content of online social networking among 2 cohorts of medical students and residents (2007 and 2009). Using the online social networking application Facebook, we evaluated social networking profiles for 2 cohorts of medical students (n  =  528) and residents (n  =  712) at the University of Florida in Gainesville. Objective measures included existence of a profile, whether it was made private, and whether any personally identifiable information was included. Subjective outcomes included photographic content, affiliated social groups, and personal information not generally disclosed in a doctor-patient encounter. We compared our results to our previously published and reported data from 2007. Social networking continues to be common amongst physicians-in-training, with 39.8% of residents and 69.5% of medical students maintaining Facebook accounts. Residents' participation significantly increased (P < .01) when compared to the 2007 data. Individuals in the 2009 cohort had significantly more "friends" (P < .01), belonged to more "groups" (P < .01), and were more likely to limit public access to their profiles through the use of privacy settings (P < .01) than the individuals in the 2007 cohort. Online social networking application use by physicians-in-training remains common. While most now limit access to their profiles, personal profiles that still allow public access exhibited a few instances of unprofessional behavior. Concerns remain related to the discovery of content in violation of patient privacy and the expansive and impersonal networks of online "friends" who may view profiles.

Investigation of remote sensing techniques of measuring soil moisture

NASA Technical Reports Server (NTRS)

Newton, R. W. (Principal Investigator); Blanchard, A. J.; Nieber, J. L.; Lascano, R.; Tsang, L.; Vanbavel, C. H. M.

1981-01-01

Major activities described include development and evaluation of theoretical models that describe both active and passive microwave sensing of soil moisture, the evaluation of these models for their applicability, the execution of a controlled field experiment during which passive microwave measurements were acquired to validate these models, and evaluation of previously acquired aircraft microwave measurements. The development of a root zone soil water and soil temperature profile model and the calibration and evaluation of gamma ray attenuation probes for measuring soil moisture profiles are considered. The analysis of spatial variability of soil information as related to remote sensing is discussed as well as the implementation of an instrumented field site for acquisition of soil moisture and meteorologic information for use in validating the soil water profile and soil temperature profile models.

Data on multicultural education and diagnostic information profiling: Culture, learning styles and creativity.

PubMed

Maseleno, Andino; Hardaker, Glenn; Sabani, Noraisikin; Suhaili, Nabilah

2016-12-01

This article contains data related to multicultural education and diagnostic information profiling preliminary findings. It includes the responses of 253 students. The data consists of six sections, i) culture: race, ethnicity, language and identity; ii) learning preferences: physiological and perceptual; iii) cognitive learning styles: physical, emotional and mental; iv) creativity skills and problem solving skills; v) motivation; and vi) students' background knowledge. The data may be used as part of data analytics for specific personalized e-learning platform.

Cross-Informant Agreement on Child and Adolescent Withdrawn Behavior: A Latent Class Approach

ERIC Educational Resources Information Center

Rubin, David H.; Althoff, Robert R.; Walkup, John T.; Hudziak, James J.

2013-01-01

Withdrawn behavior (WB) relates to many developmental outcomes, including pervasive developmental disorders, anxiety, depression, psychosis, personality disorders and suicide. No study has compared the latent profiles of different informants' reports on WB. This study uses multi-informant latent class analyses (LCA) of the child behavior checklist…

Country Demographic Profiles: Thailand.

ERIC Educational Resources Information Center

Bureau of the Census (DOC), Suitland, MD. Population Div.

This profile of the population of Thailand contains 35 tables of selected demographic information, including size of population and estimates of fertility and mortality, beginning in 1950. An adjusted distribution of the population by age and sex is given for the latest census year, as well as for 1976. Projections of the number of women of…

Exploring Oral Proficiency Profiles of Heritage Speakers of Russian and Spanish

ERIC Educational Resources Information Center

Swender, Elvira; Martin, Cynthia L.; Rivera-Martinez, Mildred; Kagan, Olga E.

2014-01-01

This article explores the linguistic profiles of heritage speakers of Russian and Spanish. Data from the 2009-2013 ACTFL-UCLA NHLRC Heritage Language Project included biographical information as well as speech samples that were elicited using the ACTFL Oral Proficiency Interview-computer and were rated according to the ACTFL Proficiency Guidelines…

Errors in reporting on dissolution research: methodological and statistical implications.

PubMed

Jasińska-Stroschein, Magdalena; Kurczewska, Urszula; Orszulak-Michalak, Daria

2017-02-01

In vitro dissolution testing provides useful information at clinical and preclinical stages of the drug development process. The study includes pharmaceutical papers on dissolution research published in Polish journals between 2010 and 2015. They were analyzed with regard to information provided by authors about chosen methods, performed validation, statistical reporting or assumptions used to properly compare release profiles considering the present guideline documents addressed to dissolution methodology and its validation. Of all the papers included in the study, 23.86% presented at least one set of validation parameters, 63.64% gave the results of the weight uniformity test, 55.68% content determination, 97.73% dissolution testing conditions, and 50% discussed a comparison of release profiles. The assumptions for methods used to compare dissolution profiles were discussed in 6.82% of papers. By means of example analyses, we demonstrate that the outcome can be influenced by the violation of several assumptions or selection of an improper method to compare dissolution profiles. A clearer description of the procedures would undoubtedly increase the quality of papers in this area.

Olympic Information in the SPORT Database.

ERIC Educational Resources Information Center

Belna, Alison M.; And Others

1984-01-01

Profiles the SPORT database, produced by Sport Information Resource Centre, Ottawa, Ontario, which provides extensive coverage of individual sports including practice, training and equipment, recreation, sports medicine, physical education, sport facilities, and international sport history. Olympic coverage in SPORT, sports sciences, online…

75 FR 39535 - Agency Information Collection Activities; Proposed Collection; Comment Request; Adverse Event...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

... Safety Network (MedSun). Additionally, the electronic form will include hospital profile information and... Device-Safety Exchange (DS-X) (formerly called M-Den), which was a moderated site where MedSun members... emerging [[Page 39536

Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry

PubMed Central

Souda, Puneet; Ryan, Christopher M.; Cramer, William A.; Whitelegge, Julian

2011-01-01

Integral membrane proteins pose challenges to traditional proteomics approaches due to unique physicochemical properties including hydrophobic transmembrane domains that limit solubility in aqueous solvents. A well resolved intact protein molecular mass profile defines a protein’s native covalent state including post-translational modifications, and is thus a vital measurement toward full structure determination. Both soluble loop regions and transmembrane regions potentially contain post-translational modifications that must be characterized if the covalent primary structure of a membrane protein is to be defined. This goal has been achieved using electrospray-ionization mass spectrometry (ESI-MS) with low-resolution mass analyzers for intact protein profiling, and high-resolution instruments for top-down experiments, toward complete covalent primary structure information. In top-down, the intact protein profile is supplemented by gas-phase fragmentation of the intact protein, including its transmembrane regions, using collisionally activated and/or electroncapture dissociation (CAD/ECD) to yield sequence-dependent high-resolution MS information. Dedicated liquid chromatography systems with aqueous/organic solvent mixtures were developed allowing us to demonstrate that polytopic integral membrane proteins are amenable to ESI-MS analysis, including top-down measurements. Covalent post-translational modifications are localized regardless of their position in transmembrane domains. Top-down measurements provide a more detail oriented high-resolution description of post-transcriptional and post-translational diversity for enhanced understanding beyond genomic translation. PMID:21982782

Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry.

PubMed

Souda, Puneet; Ryan, Christopher M; Cramer, William A; Whitelegge, Julian

2011-12-01

Integral membrane proteins pose challenges to traditional proteomics approaches due to unique physicochemical properties including hydrophobic transmembrane domains that limit solubility in aqueous solvents. A well resolved intact protein molecular mass profile defines a protein's native covalent state including post-translational modifications, and is thus a vital measurement toward full structure determination. Both soluble loop regions and transmembrane regions potentially contain post-translational modifications that must be characterized if the covalent primary structure of a membrane protein is to be defined. This goal has been achieved using electrospray-ionization mass spectrometry (ESI-MS) with low-resolution mass analyzers for intact protein profiling, and high-resolution instruments for top-down experiments, toward complete covalent primary structure information. In top-down, the intact protein profile is supplemented by gas-phase fragmentation of the intact protein, including its transmembrane regions, using collisionally activated and/or electron-capture dissociation (CAD/ECD) to yield sequence-dependent high-resolution MS information. Dedicated liquid chromatography systems with aqueous/organic solvent mixtures were developed allowing us to demonstrate that polytopic integral membrane proteins are amenable to ESI-MS analysis, including top-down measurements. Covalent post-translational modifications are localized regardless of their position in transmembrane domains. Top-down measurements provide a more detail oriented high-resolution description of post-transcriptional and post-translational diversity for enhanced understanding beyond genomic translation. Copyright © 2011 Elsevier Inc. All rights reserved.

A Retrospective and Prospective View of Information Retrieval and Artificial Intelligence in the 21st Century.

ERIC Educational Resources Information Center

Garfield, Eugene

2001-01-01

Traces the development of information retrieval/services and suggests that the creation of large digital libraries seems inevitable. Examines possibilities for increasing electronic access and the role of artificial intelligence. Highlights include: searching full text; sending full texts; selective dissemination of information (SDI) profiling and…

User Information Needs: The Challenge and a Response.

ERIC Educational Resources Information Center

Goodman, A. F.; Jones, S.O.

Described are the aims, goals, and methods of literature search of the Mechanized Library Information System serving West Coast locations of the McDonnell Douglas Corporation. Brief reports on two pilot programs, one on information awareness, and the other on a capability profile system for locating key personnel, are included. The first program…

Assessing Information on the Internet: Toward Providing Library Services for Computer-Mediated Communication.

ERIC Educational Resources Information Center

Dillon, Martin; And Others

1992-01-01

Describes a project that examined textual information available on the Internet and potential means of providing access to this information. Highlights include an overview of Internet resources, a profile of a document sample, description of FTP (File Transfer Protocol) sites, and an automated method of categorizing files. (MES)

Exploitation of molecular profiling techniques for GM food safety assessment.

PubMed

Kuiper, Harry A; Kok, Esther J; Engel, Karl-Heinz

2003-04-01

Several strategies have been developed to identify unintended alterations in the composition of genetically modified (GM) food crops that may occur as a result of the genetic modification process. These include comparative chemical analysis of single compounds in GM food crops and their conventional non-GM counterparts, and profiling methods such as DNA/RNA microarray technologies, proteomics and metabolite profiling. The potential of profiling methods is obvious, but further exploration of specificity, sensitivity and validation is needed. Moreover, the successful application of profiling techniques to the safety evaluation of GM foods will require linked databases to be built that contain information on variations in profiles associated with differences in developmental stages and environmental conditions.

IHE cross-enterprise document sharing for imaging: design challenges

NASA Astrophysics Data System (ADS)

Noumeir, Rita

2006-03-01

Integrating the Healthcare Enterprise (IHE) has recently published a new integration profile for sharing documents between multiple enterprises. The Cross-Enterprise Document Sharing Integration Profile (XDS) lays the basic framework for deploying regional and national Electronic Health Record (EHR). This profile proposes an architecture based on a central Registry that holds metadata information describing published Documents residing in one or multiple Documents Repositories. As medical images constitute important information of the patient health record, it is logical to extend the XDS Integration Profile to include images. However, including images in the EHR presents many challenges. The complete image set is very large; it is useful for radiologists and other specialists such as surgeons and orthopedists. The imaging report, on the other hand, is widely needed and its broad accessibility is vital for achieving optimal patient care. Moreover, a subset of relevant images may also be of wide interest along with the report. Therefore, IHE recently published a new integration profile for sharing images and imaging reports between multiple enterprises. This new profile, the Cross-Enterprise Document Sharing for Imaging (XDS-I), is based on the XDS architecture. The XDS-I integration solution that is published as part of the IHE Technical Framework is the result of an extensive investigation effort of several design solutions. This paper presents and discusses the design challenges and the rationales behind the design decisions of the IHE XDS-I Integration Profile, for a better understanding and appreciation of the final published solution.

Defense.gov Special Report: National Disability Employment Awareness Month

Science.gov Websites

service at the U.S. Army Corps of Engineers, DeLisa L. Kviz currently works as chief ... Profile photo of of service with the Department of the Navy, including over 11 years ... Profile photo of Ivan E is a technical information specialist in the Analysis and ... Profile photo of Chad A. Molenhour

Compound Structure-Independent Activity Prediction in High-Dimensional Target Space.

PubMed

Balfer, Jenny; Hu, Ye; Bajorath, Jürgen

2014-08-01

Profiling of compound libraries against arrays of targets has become an important approach in pharmaceutical research. The prediction of multi-target compound activities also represents an attractive task for machine learning with potential for drug discovery applications. Herein, we have explored activity prediction in high-dimensional target space. Different types of models were derived to predict multi-target activities. The models included naïve Bayesian (NB) and support vector machine (SVM) classifiers based upon compound structure information and NB models derived on the basis of activity profiles, without considering compound structure. Because the latter approach can be applied to incomplete training data and principally depends on the feature independence assumption, SVM modeling was not applicable in this case. Furthermore, iterative hybrid NB models making use of both activity profiles and compound structure information were built. In high-dimensional target space, NB models utilizing activity profile data were found to yield more accurate activity predictions than structure-based NB and SVM models or hybrid models. An in-depth analysis of activity profile-based models revealed the presence of correlation effects across different targets and rationalized prediction accuracy. Taken together, the results indicate that activity profile information can be effectively used to predict the activity of test compounds against novel targets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

EvoDB: a database of evolutionary rate profiles, associated protein domains and phylogenetic trees for PFAM-A

PubMed Central

Ndhlovu, Andrew; Durand, Pierre M.; Hazelhurst, Scott

2015-01-01

The evolutionary rate at codon sites across protein-coding nucleotide sequences represents a valuable tier of information for aligning sequences, inferring homology and constructing phylogenetic profiles. However, a comprehensive resource for cataloguing the evolutionary rate at codon sites and their corresponding nucleotide and protein domain sequence alignments has not been developed. To address this gap in knowledge, EvoDB (an Evolutionary rates DataBase) was compiled. Nucleotide sequences and their corresponding protein domain data including the associated seed alignments from the PFAM-A (protein family) database were used to estimate evolutionary rate (ω = dN/dS) profiles at codon sites for each entry. EvoDB contains 98.83% of the gapped nucleotide sequence alignments and 97.1% of the evolutionary rate profiles for the corresponding information in PFAM-A. As the identification of codon sites under positive selection and their position in a sequence profile is usually the most sought after information for molecular evolutionary biologists, evolutionary rate profiles were determined under the M2a model using the CODEML algorithm in the PAML (Phylogenetic Analysis by Maximum Likelihood) suite of software. Validation of nucleotide sequences against amino acid data was implemented to ensure high data quality. EvoDB is a catalogue of the evolutionary rate profiles and provides the corresponding phylogenetic trees, PFAM-A alignments and annotated accession identifier data. In addition, the database can be explored and queried using known evolutionary rate profiles to identify domains under similar evolutionary constraints and pressures. EvoDB is a resource for evolutionary, phylogenetic studies and presents a tier of information untapped by current databases. Database URL: http://www.bioinf.wits.ac.za/software/fire/evodb PMID:26140928

EvoDB: a database of evolutionary rate profiles, associated protein domains and phylogenetic trees for PFAM-A.

PubMed

Ndhlovu, Andrew; Durand, Pierre M; Hazelhurst, Scott

2015-01-01

The evolutionary rate at codon sites across protein-coding nucleotide sequences represents a valuable tier of information for aligning sequences, inferring homology and constructing phylogenetic profiles. However, a comprehensive resource for cataloguing the evolutionary rate at codon sites and their corresponding nucleotide and protein domain sequence alignments has not been developed. To address this gap in knowledge, EvoDB (an Evolutionary rates DataBase) was compiled. Nucleotide sequences and their corresponding protein domain data including the associated seed alignments from the PFAM-A (protein family) database were used to estimate evolutionary rate (ω = dN/dS) profiles at codon sites for each entry. EvoDB contains 98.83% of the gapped nucleotide sequence alignments and 97.1% of the evolutionary rate profiles for the corresponding information in PFAM-A. As the identification of codon sites under positive selection and their position in a sequence profile is usually the most sought after information for molecular evolutionary biologists, evolutionary rate profiles were determined under the M2a model using the CODEML algorithm in the PAML (Phylogenetic Analysis by Maximum Likelihood) suite of software. Validation of nucleotide sequences against amino acid data was implemented to ensure high data quality. EvoDB is a catalogue of the evolutionary rate profiles and provides the corresponding phylogenetic trees, PFAM-A alignments and annotated accession identifier data. In addition, the database can be explored and queried using known evolutionary rate profiles to identify domains under similar evolutionary constraints and pressures. EvoDB is a resource for evolutionary, phylogenetic studies and presents a tier of information untapped by current databases. © The Author(s) 2015. Published by Oxford University Press.

Facebook use among early-career veterinarians in Ontario, Canada (March to May 2010).

PubMed

Weijs, Cynthia A; Coe, Jason B; Christofides, Emily; Muise, Amy; Desmarais, Serge

2013-04-15

To explore the nature and content of information publicly posted to Facebook by early-career veterinarians. Cross-sectional descriptive study. Sample-352 early-career veterinarians. Publicly accessible Facebook profiles were searched online from March to May 2010 for profiles of early-career veterinarians (graduates from 2004 through 2009) registered with the College of Veterinarians of Ontario, Canada. The content of veterinarians' Facebook profiles was evaluated and then categorized as low, medium, or high exposure in terms of the information a veterinarian had publicly posted to Facebook. Through the use of content analysis, high-exposure profiles were further analyzed for publicly posted information that may have posed risks to an individual's or the profession's public image. Facebook profiles for 352 of 494 (71%) registered early-career veterinarians were located. One-quarter (25%) of profiles were categorized as low exposure (ie, high privacy), over half (54%) as medium exposure (i.e., medium privacy), and 21% as high exposure (i.e., low privacy). Content analysis of the high-exposure profiles identified publicly posted information that may pose risks to an individual's or the profession's reputation, including breaches of client confidentiality, evidence of substance abuse, and demeaning comments toward others. Almost a quarter of veterinarians' Facebook profiles viewed in the present study contained publicly available content of a questionable nature that could pose a risk to the reputation of the individual, his or her practice, or the veterinary profession. The increased use of Facebook and all types of social media points to the need for raised awareness by veterinarians of all ages of how to manage one's personal and professional identities online to minimize reputation risks for individuals and their practices and to protect the reputation and integrity of the veterinary profession.

Anchorage School District Profile of Performance 1997-98. Assessment and Evaluation Report #98-3.

ERIC Educational Resources Information Center

Fenton, Ray

The Anchorage School District (Alaska) provides a comprehensive program of education to students from kindergarten through grade 12. This profile focuses on student achievement and other outcome indicators of student success, but it does not include information on the social or physical wellness of Anchorage students. The first section gives an…

Preventing and Profiling Malicious Insider Attacks

DTIC Science & Technology

2012-04-01

malicious insiders. This research program could also be extended to look at general human factors issues surrounding information security behaviours ... behaviours . This research also draws on corresponding studies into fraud and espionage in non IT scenarios. A range of preventative measures is...This includes motivating factors, personality traits and observable behaviours that may assist organisations in the detection and profiling of

Occupational Competency Profile for Health Occupations Education Program: Teacher Self-Assessment. Information Series: Report No. 11.

ERIC Educational Resources Information Center

Walters, Norma J.

This assessment instrument is intended to assist teachers in evaluating the relevance of the competencies included in the health occupations education curriculum they are teaching and in assessing their own continuing education needs. The profile lists the competencies required of persons working at the following sites: hospital departments…

Burnout and the Library Administrator: Carrier or Cure.

ERIC Educational Resources Information Center

Smith, Nathan M.; And Others

1988-01-01

Discussion of burnout among library personnel includes a susceptibility profile, indicators of burnout, and administrative contributors. Techniques by which administrators can reduce stress are suggested, including participative management; improved communications; staff development; informal staff gatherings; staff meetings; flexible work…

A national medical register: balancing public transparency and professional privacy.

PubMed

Healy, Judith M; Maffi, Costanza L; Dugdale, Paul

2008-02-18

The first aim of a medical registration scheme should be to protect patients. Medical registration boards currently offer variable information to the public on doctors' registration status. Current reform proposals for a national registration scheme should include free public access to professional profiles of registered medical practitioners. Practitioner profiles should include: practitioner's full name and practice address; type of qualifications; year first registered, and duration and type of registration; any conditions on registration and practice; any disciplinary action taken; and participation in continuing professional education.

Validation of Metabolomic, Diagnostic, and Prognostic Classifiers of Lung Cancer

DTIC Science & Technology

2016-10-01

information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this...Additionally, global metabolomic profiling will allow us to interrogate whether the military have unique exposures that may be related to lung cancer

14 CFR 101.29 - Information requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

...—High-Power Rocket requires a certificate of waiver or authorization, the person planning the operation... certificate of waiver or authorization the person planning the operation must provide the information below... characteristics for the entire flight profile, (4) A description of all major rocket systems, including structural...

14 CFR 101.29 - Information requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

...—High-Power Rocket requires a certificate of waiver or authorization, the person planning the operation... certificate of waiver or authorization the person planning the operation must provide the information below... characteristics for the entire flight profile, (4) A description of all major rocket systems, including structural...

14 CFR 101.29 - Information requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

...—High-Power Rocket requires a certificate of waiver or authorization, the person planning the operation... certificate of waiver or authorization the person planning the operation must provide the information below... characteristics for the entire flight profile, (4) A description of all major rocket systems, including structural...

14 CFR 101.29 - Information requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

...—High-Power Rocket requires a certificate of waiver or authorization, the person planning the operation... certificate of waiver or authorization the person planning the operation must provide the information below... characteristics for the entire flight profile, (4) A description of all major rocket systems, including structural...

MO-AB-204-01: IHE RO Overview [Health Care

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadley, S.

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

MO-AB-204-02: IHE RAD [Health care

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seibert, J.

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

MO-AB-204-04: Connectathons and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bosch, W.

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

Scaling of confinement and profiles in the EXTRAP T2 reversed-field pinch

NASA Astrophysics Data System (ADS)

Welander, A.

1999-01-01

In the EXTRAP T2 reversed-field pinch the diagnostic techniques for the measurement of electron density and temperature include; Thomson scattering which gives values at three radial positions in the core (r/a = 0, 0.28, 0.56), Langmuir probes which give values at the edge (r/a > 0.9) and interferometry which gives a line-averaged density. The empirical scaling of electron density and temperature including profile information with global plasma parameters has been studied. The density profile is subject to large variations, with an average parabolic shape when the density is low and flatter shapes when the density is increased. The change in the profile shape can be attributed to a shift in the penetration length of neutrals from the vicinity of the wall. The temperature scales roughly as I/n1/2 where I is the plasma current and n is the density. The temperature profile is always quite flat with lower variations and there is a tendency for a flatter profile at higher temperatures.

Archive of chirp seismic reflection data collected during USGS cruises 00SCC02 and 00SCC04, Barataria Basin, Louisiana, May 12-31 and June 17-July 2, 2000

USGS Publications Warehouse

Calderon, Karynna; Dadisman, S.V.; Kindinger, J.L.; Flocks, J.G.; Wiese, D.S.; Kulp, Mark; Penland, Shea; Britsch, L.D.; Brooks, G.R.

2003-01-01

This archive consists of two-dimensional marine seismic reflection profile data collected in the Barataria Basin of southern Louisiana. These data were acquired in May, June, and July of 2000 aboard the R/V G.K. Gilbert. Included here are data in a variety of formats including binary, American Standard Code for Information Interchange (ASCII), Hyper-Text Markup Language (HTML), shapefiles, and Graphics Interchange Format (GIF) and Joint Photographic Experts Group (JPEG) images. Binary data are in Society of Exploration Geophysicists (SEG) SEG-Y format and may be downloaded for further processing or display. Reference maps and GIF images of the profiles may be viewed with a web browser. The Geographic Information Systems (GIS) information provided here is compatible with Environmental Systems Research Institute (ESRI) GIS software.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aabakken, J.

This report, prepared by NREL's Strategic Energy Analysis Center, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, and conversion factors.

Retrieval of profile information from airborne multiaxis UV-visible skylight absorption measurements.

PubMed

Bruns, Marco; Buehler, Stefan A; Burrows, John P; Heue, Klaus-Peter; Platt, Ulrich; Pundt, Irene; Richter, Andreas; Rozanov, Alexej; Wagner, Thomas; Wang, Ping

2004-08-01

A recent development in ground-based remote sensing of atmospheric constituents by UV-visible absorption measurements of scattered light is the simultaneous use of several horizon viewing directions in addition to the traditional zenith-sky pointing. The different light paths through the atmosphere enable the vertical distribution of some atmospheric absorbers, such as NO2, BrO, or O3, to be retrieved. This approach has recently been implemented on an airborne platform. This novel instrument, the airborne multiaxis differential optical absorption spectrometer (AMAXDOAS), has been flown for the first time. In this study, the amount of profile information that can be retrieved from such measurements is investigated for the trace gas NO2. Sensitivity studies on synthetic data are performed for a variety of representative measurement conditions including two wavelengths, one in the UV and one in the visible, two different surface spectral reflectances, various lines of sight (LOSs), and for two different flight altitudes. The results demonstrate that the AMAXDOAS measurements contain useful profile information, mainly at flight altitude and below the aircraft. Depending on wavelength and LOS used, the vertical resolution of the retrieved profiles is as good as 2 km near flight altitude. Above 14 km the profile information content of AMAXDOAS measurements is sparse. Airborne multiaxis measurements are thus a promising tool for atmospheric studies in the troposphere and the upper troposphere and lower stratosphere region.

Section 619 Profile, 19th Edition

ERIC Educational Resources Information Center

Lazara, A., Ed.; Danaher, J., Ed.; Kraus, R., Ed.; Goode, S., Ed.; Hipps, C., Ed.; Festa, C., Ed.

2012-01-01

This 2012 edition of this publication updates information provided by state coordinators on state policies, programs, and practices under the Preschool Grants Program (Section 619 of Part B) of the Individuals with Disabilities Education Act (IDEA). Information includes: (1) program administration; (2) funding; (3) interagency coordination; (4)…

The Impact of Atmospheric InfraRed Sounder (AIRS) Profiles on Short-term Weather Forecasts

NASA Technical Reports Server (NTRS)

Chou, Shih-Hung; Zavodsky, Brad; Jedlovec, Gary J.; Lapenta, William

2007-01-01

The Atmospheric Infrared Sounder (AIRS), together with the Advanced Microwave Sounding Unit (AMSU), represents one of the most advanced spacebased atmospheric sounding systems. The combined AlRS/AMSU system provides radiance measurements used to retrieve temperature profiles with an accuracy of 1 K over 1 km layers under both clear and partly cloudy conditions, while the accuracy of the derived humidity profiles is 15% in 2 km layers. Critical to the successful use of AIRS profiles for weather and climate studies is the use of profile quality indicators and error estimates provided with each profile Aside form monitoring changes in Earth's climate, one of the objectives of AIRS is to provide sounding information of sufficient accuracy such that the assimilation of the new observations, especially in data sparse region, will lead to an improvement in weather forecasts. The purpose of this paper is to describe a procedure to optimally assimilate highresolution AIRS profile data in a regional analysis/forecast model. The paper will focus on the impact of AIRS profiles on a rapidly developing east coast storm and will also discuss preliminary results for a 30-day forecast period, simulating a quasi-operation environment. Temperature and moisture profiles were obtained from the prototype version 5.0 EOS science team retrieval algorithm which includes explicit error information for each profile. The error profile information was used to select the highest quality temperature and moisture data for every profile location and pressure level for assimilation into the ARPS Data Analysis System (ADAS). The AIRS-enhanced analyses were used as initial fields for the Weather Research and Forecast (WRF) system used by the SPORT project for regional weather forecast studies. The ADASWRF system will be run on CONUS domain with an emphasis on the east coast. The preliminary assessment of the impact of the AIRS profiles will focus on quality control issues associated with AIRS, intelligent use of the quality indicators, and forecast verification.

Health Insurance Data

MedlinePlus

... define geographic areas and how geography changes over time. Latest Information ... audio files from the Census Bureau, including "Profile America," a daily series of bite-sized statistics, placing current data in ...

Social networking profiles and professionalism issues in residency applicants: an original study-cohort study.

PubMed

Ponce, Brent A; Determann, Jason R; Boohaker, Hikel A; Sheppard, Evan; McGwin, Gerald; Theiss, Steven

2013-01-01

To determine the frequency of social networking, the degree of information publicly disclosed, and whether unprofessional content was identified in applicants from the 2010 Residency Match. Medical professionalism is an essential competency for physicians to learn, and information found on social networking sites may be hazardous to the doctor-patient relationship and an institution's public perception. No study has analyzed the social network content of applicants applying for residency. Online review of social networking Facebook profiles of graduating medical students applying for a residency in orthopedic surgery. Evidence of unprofessional content was based upon Accreditation Council for Graduate Medical Education guidelines. Additional recorded applicant data included as follows: age, United States Medical Licensing Examination part I score, and residency composite score. Relationship between professionalism score and recorded data points was evaluated using an analysis of variance. Nearly half of all applicants, 46% (200/431), had a Facebook profile. The majority of profiles (85%) did not restrict online access to their profile. Unprofessional content was identified in 16% of resident applicant profiles. Variables associated with lower professionalism scores included unmarried relationship status and lower residency composite scores. It is critical for healthcare professionals to recognize both the benefits and risks present with electronic communication and to vigorously protect the content of material allowed to be publically accessed through the Internet. Copyright © 2013 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Optimum Strategies for Selecting Descent Flight-Path Angles

NASA Technical Reports Server (NTRS)

Wu, Minghong G. (Inventor); Green, Steven M. (Inventor)

2016-01-01

An information processing system and method for adaptively selecting an aircraft descent flight path for an aircraft, are provided. The system receives flight adaptation parameters, including aircraft flight descent time period, aircraft flight descent airspace region, and aircraft flight descent flyability constraints. The system queries a plurality of flight data sources and retrieves flight information including any of winds and temperatures aloft data, airspace/navigation constraints, airspace traffic demand, and airspace arrival delay model. The system calculates a set of candidate descent profiles, each defined by at least one of a flight path angle and a descent rate, and each including an aggregated total fuel consumption value for the aircraft following a calculated trajectory, and a flyability constraints metric for the calculated trajectory. The system selects a best candidate descent profile having the least fuel consumption value while the fly ability constraints metric remains within aircraft flight descent flyability constraints.

Testing in America's Schools. Policy Information Report.

ERIC Educational Resources Information Center

Barton, Paul E.; Coley, Richard J.

This report provides a profile of state testing programs in 1992-93, as well as a view of classroom testing practices by state, school district, school, or individual teacher. Information, taken from a variety of sources, including the National Assessment of Educational Progress and a General Accounting Office study, indicates that the…

Professional organisation profile: a faculty of expedition and wilderness medicine for Australasia.

PubMed

Leggat, Peter A; Shaw, Marc T M

2012-05-01

A profile of the recent genesis of the Sub-Faculty of Expedition Medicine into a Faculty of Expedition and Wilderness Medicine of The Australasian College of Tropical Medicine is presented. Information is given on aims, structure, professional grades of membership, and the various activities of the Faculty, including publications and scientific meetings. Copyright © 2012 Elsevier Ltd. All rights reserved.

General Achievement Trends: Alabama

ERIC Educational Resources Information Center

Center on Education Policy, 2009

2009-01-01

This general achievement trends profile includes information that the Center on Education Policy (CEP) and the Human Resources Research Organization (HumRRO) obtained from states from fall 2008 through April 2009. Included herein are: (1) Bullet points summarizing key findings about achievement trends in that state at three performance…

Information content of ozone retrieval algorithms

NASA Technical Reports Server (NTRS)

Rodgers, C.; Bhartia, P. K.; Chu, W. P.; Curran, R.; Deluisi, J.; Gille, J. C.; Hudson, R.; Mateer, C.; Rusch, D.; Thomas, R. J.

1989-01-01

The algorithms are characterized that were used for production processing by the major suppliers of ozone data to show quantitatively: how the retrieved profile is related to the actual profile (This characterizes the altitude range and vertical resolution of the data); the nature of systematic errors in the retrieved profiles, including their vertical structure and relation to uncertain instrumental parameters; how trends in the real ozone are reflected in trends in the retrieved ozone profile; and how trends in other quantities (both instrumental and atmospheric) might appear as trends in the ozone profile. No serious deficiencies were found in the algorithms used in generating the major available ozone data sets. As the measurements are all indirect in someway, and the retrieved profiles have different characteristics, data from different instruments are not directly comparable.

MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

Investigation of the structure and lithology of bedrock concealed by basin fill, using ground-based magnetic-field-profile data acquired in the San Rafael Basin, southeastern Arizona

USGS Publications Warehouse

Bultman, Mark W.

2013-01-01

Data on the Earth’s total-intensity magnetic field acquired near ground level and at measurement intervals as small as 1 m include information on the spatial distribution of nearsurface magnetic dipoles that in many cases are unique to a specific lithology. Such spatial information is expressed in the texture (physical appearance or characteristics) of the data at scales of hundreds of meters to kilometers. These magnetic textures are characterized by several descriptive statistics, their power spectrum, and their multifractal spectrum. On the basis of a graphical comparison and textural characterization, ground-based magnetic-field profile data can be used to estimate bedrock lithology concealed by as much as 100 m of basin fill in some cases, information that is especially important in assessing and exploring for concealed mineral deposits. I demonstrate that multifractal spectra of ground-based magnetic-field-profile data can be used to differentiate exposed lithologies and that the shape and position of the multifractal spectrum of the ground-based magnetic-field-profile of concealed lithologies can be matched to the upward-continued multifractal spectrum of an exposed lithology to help distinguish the concealed lithology. In addition, ground-based magnetic-field-profile data also detect minute differences in the magnetic susceptibility of rocks over small horizontal and vertical distances and so can be used for precise modeling of bedrock geometry and structure, even when that bedrock is concealed by 100 m or more of nonmagnetic basin fill. Such data contain valuable geologic information on the bedrock concealed by basin fill that may not be so visible in aeromagnetic data, including areas of hydrothermal alteration, faults, and other bedrock structures. Interpretation of these data in the San Rafael Basin, southeastern Arizona, has yielded results for estimating concealed lithologies, concealed structural geology, and a concealed potential mineral-resource target.

Sampling Soil for Characterization and Site Description

NASA Technical Reports Server (NTRS)

Levine, Elissa

1999-01-01

The sampling scheme for soil characterization within the GLOBE program is uniquely different from the sampling methods of the other protocols. The strategy is based on an understanding of the 5 soil forming factors (parent material, climate, biota, topography, and time) at each study site, and how each of these interact to produce a soil profile with unique characteristics and unique input and control into the atmospheric, biological, and hydrological systems. Soil profile characteristics, as opposed to soil moisture and temperature, vegetative growth, and atmospheric and hydrologic conditions, change very slowly, depending on the parameter being measured, ranging from seasonally to many thousands of years. Thus, soil information, including profile description and lab analysis, is collected only one time for each profile at a site. These data serve two purposes: 1) to supplement existing spatial information about soil profile characteristics across the landscape at local, regional, and global scales, and 2) to provide specific information within a given area about the basic substrate to which elements within the other protocols are linked. Because of the intimate link between soil properties and these other environmental elements, the static soil properties at a given site are needed to accurately interpret and understand the continually changing dynamics of soil moisture and temperature, vegetation growth and phenology, atmospheric conditions, and chemistry and turbidity in surface waters. Both the spatial and specific soil information can be used for modeling purposes to assess and make predictions about global change.

General Achievement Trends: New Hampshire

ERIC Educational Resources Information Center

Center on Education Policy, 2009

2009-01-01

This general achievement trends profile includes information that the Center on Education Policy (CEP) and the Human Resources Research Organization (HumRRO) obtained from states from fall 2008 through April 2009. Included herein are: (1) Bullet points summarizing key findings about achievement trends in that state at three performance…

Transition V & VI in Alabama: A Profile of Commitment. State Conference Proceedings.

ERIC Educational Resources Information Center

Browning, Philip; Rabren, Karen

This publication provides information on the Alabama Transition Initiative for students with disabilities, including papers presented at two statewide transition conferences. Conference papers include: (1) "Pell City School System's Community Transition Team Model" (Deloris Frasier); (2) "Alabama's MH/MR Service Coordinators in…

78 FR 15725 - Agency Information Collection Activities; Proposed Collection; Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

... initiative will include nutritional and physical activity counseling and activities, and will be implemented...] Agency Information Collection Activities; Proposed Collection; Public Comment Request AGENCY: Office of... Survey 40 1 15/60 10 Pedometer Profile 40 1 2/60 1 Health Screen (physical measurement) 40 3 10/60 20...

Teachers' Intentions to Use National Literacy and Numeracy Assessment Data: A Pilot Study

ERIC Educational Resources Information Center

Pierce, Robyn; Chick, Helen

2011-01-01

In recent years the educational policy environment has emphasised data-driven change. This has increased the expectation for school personnel to use statistical information to inform their programs and to improve teaching practices. Such data include system reports of student achievement tests and socio-economic profiles provided to schools by…

77 FR 68104 - Proposed Information Collection; Comment Request; Socio-Economic Profile of Small-Scale...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... strengthen and improve fishery management decision-making, satisfy legal mandates under Executive Order 12866... have practical utility; (b) the accuracy of the agency's estimate of the burden (including hours and cost) of the proposed collection of information; (c) ways to enhance the quality, utility, and clarity...

Structure-Templated Predictions of Novel Protein Interactions from Sequence Information

PubMed Central

Betel, Doron; Breitkreuz, Kevin E; Isserlin, Ruth; Dewar-Darch, Danielle; Tyers, Mike; Hogue, Christopher W. V

2007-01-01

The multitude of functions performed in the cell are largely controlled by a set of carefully orchestrated protein interactions often facilitated by specific binding of conserved domains in the interacting proteins. Interacting domains commonly exhibit distinct binding specificity to short and conserved recognition peptides called binding profiles. Although many conserved domains are known in nature, only a few have well-characterized binding profiles. Here, we describe a novel predictive method known as domain–motif interactions from structural topology (D-MIST) for elucidating the binding profiles of interacting domains. A set of domains and their corresponding binding profiles were derived from extant protein structures and protein interaction data and then used to predict novel protein interactions in yeast. A number of the predicted interactions were verified experimentally, including new interactions of the mitotic exit network, RNA polymerases, nucleotide metabolism enzymes, and the chaperone complex. These results demonstrate that new protein interactions can be predicted exclusively from sequence information. PMID:17892321

Personal and professional profile of mountain medicine physicians.

PubMed

Peters, Patrick

2003-01-01

The purpose of this study was to define and describe the personal and professional profile of mountain medicine physicians including general physical training information and to include a detailed overview of the practice of mountain sports. A group of physicians participating in a specialized mountain medicine education program filled out a standardized questionnaire. The data obtained from this questionnaire were first analyzed in a descriptive way and then by statistical methods (chi2 test, t test, and analysis of variance). Detailed results have been provided for gender, age, marital status, general training frequency and methods, professional status, additional medical qualifications, memberships in professional societies and alpine clubs, mountain sports practice, and injuries sustained during the practice of mountain sports. This study has provided a detailed overview concerning the personal and professional profile of mountain medicine physicians. Course organizers as well as official commissions regulating the education in mountain medicine will be able to use this information to adapt and optimize the courses and the recommendations/requirements as detailed by the UIAA-ICAR-ISMM (Union Internationale des Associations Alpinistes, International Commission for Alpine Rescue, International Society for Mountain Medicine).

Survey on the use of information sources in the field of aging.

PubMed

Bird, G; Heekin, J M

1994-01-01

This article presents the results of a survey conducted over the summer of 1992 on the use of information sources by professionals in the field of aging. In particular, factors affecting the use of electronic information sources were investigated. The data provide a demographic profile of North American gerontologists, with a predictably wide range of disciplines and types of practice represented. Several factors were found to have an impact on the gerontologists' utilization of electronic information sources. Respondents who used a larger-than-average number of computer applications were found to make relatively more use of electronic sources, including online searches, CD-ROM indexes, library OPACs, and other databases searched by remote access. Attendance at library workshops was found to increase the amount of end-user searching but not the amount of library-mediated searching. Respondents also reported which databases they used and which they considered most important. MEDLINE was the most frequently mentioned database across all disciplines, including the health and social sciences. Computer databases were ranked least important out of six listed sources of information, and only 5% of respondents reported having used an electronic current awareness profile.

Older adolescents’ views regarding participation in Facebook research

PubMed Central

Moreno, Megan A; Grant, Alison; Kacvinsky, Lauren; Moreno, Peter; Fleming, Michael

2012-01-01

Purpose Facebook continues to grow in popularity among adolescents as well as adolescent researchers. Guidance on conducting this research with appropriate attention to privacy and ethics is scarce. To inform such research efforts, the purpose of this study was to determine older adolescents’ responses after learning that they were participants in a research study that involved identification of participants using Facebook. Methods Public Facebook profiles of older adolescents age 18 to 19 years from a large state university were examined. Profile owners were then interviewed. During the interview participants were informed that they were identified by examining publicly available Facebook profiles. Participants were asked to discuss their views on this research method. Results A total of 132 participants completed the interview (70% response rate), the average age was 18.4 years (SD=0.5) and our sample included 64 males (48.5%). Participant responses included: endorsement (19.7%), fine (36.4%), neutral (28.8%), uneasy (9.1%) and concerned (6.1%). Among participants who were uneasy or concerned, the majority voiced confusion regarding their current profile security settings (p=0.00). Conclusion The majority of adolescent participants viewed the use of Facebook for research positively. These findings are consistent with the approach taken by many US courts. Researchers may consider these findings when developing research protocols involving Facebook. PMID:23084164

ISS Expedition 42 Crew Profiles - Version 01

NASA Image and Video Library

2014-11-14

Narrated program with biographical information about ISS Expedition 42 crewmembers Terry Virts, Samantha Cristoforetti and Anton Shjaplerov. The program covers the crewmember's career including childhood photographs; footage from previous missions; and interview sound bites.

Women in Delaware: A Documented Profile.

ERIC Educational Resources Information Center

Stewart, Hester R.; Cannon, Mary E.

A source of demographic data concerning the status of women in Delaware, this document includes multiple charts, graphs, and statistical information concerning women in the areas of (1) population characteristics, (2) marital status and living arrangements, (3) labor force participation, and (4) income and earnings. Included are data for the…

Will We Soon Have a Geostationary Microwave Sounder and What Can We Do with It?

NASA Technical Reports Server (NTRS)

Lambrigtsen, Bjorn

2008-01-01

This slide presentation reviews the Geostationary Microwave Sounder (GEO/MW). GEO/MW applications include weather forecasting, hurricane diagnostics, rain, tropospheric wind profiling, and climate research. The presentation also includes information on prototype development, system tests, the notational PATH mission, and data products.

Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics

NASA Astrophysics Data System (ADS)

Lindon, John C.; Nicholson, Jeremy K.

2008-07-01

Methods for generating and interpreting metabolic profiles based on nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and chemometric analysis methods are summarized and the relative strengths and weaknesses of NMR and chromatography-coupled MS approaches are discussed. Given that all data sets measured to date only probe subsets of complex metabolic profiles, we describe recent developments for enhanced information recovery from the resulting complex data sets, including integration of NMR- and MS-based metabonomic results and combination of metabonomic data with data from proteomics, transcriptomics, and genomics. We summarize the breadth of applications, highlight some current activities, discuss the issues relating to metabonomics, and identify future trends.

Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics.

PubMed

Lindon, John C; Nicholson, Jeremy K

2008-01-01

Methods for generating and interpreting metabolic profiles based on nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and chemometric analysis methods are summarized and the relative strengths and weaknesses of NMR and chromatography-coupled MS approaches are discussed. Given that all data sets measured to date only probe subsets of complex metabolic profiles, we describe recent developments for enhanced information recovery from the resulting complex data sets, including integration of NMR- and MS-based metabonomic results and combination of metabonomic data with data from proteomics, transcriptomics, and genomics. We summarize the breadth of applications, highlight some current activities, discuss the issues relating to metabonomics, and identify future trends.

STS-1 medical report

NASA Technical Reports Server (NTRS)

Pool, S. L. (Editor); Johnson, P. C., Jr. (Editor); Mason, J. A. (Editor)

1981-01-01

The report includes a review of the health of the crew before, during and immediately after the first Shuttle orbital flight (April 12-14, 1981). Areas reviewed include: health evaluation, medical debriefing of crewmembers, health stabilization program, medical training, medical kit carried inflight; tests and countermeasures for space motion sickness, cardiovascular profile, biochemistry and endocrinology results; hematology and immunology analyses; medical microbiology; food and nutrition; potable water; shuttle toxicology; radiological health; cabin acoustical noise. Also included is information on: environmental effects of Shuttle launch and landing, medical information management; and management, planning and implementation of the medical program.

A Flexible Workflow for Automated Bioluminescent Kinase Selectivity Profiling.

PubMed

Worzella, Tracy; Butzler, Matt; Hennek, Jacquelyn; Hanson, Seth; Simdon, Laura; Goueli, Said; Cowan, Cris; Zegzouti, Hicham

2017-04-01

Kinase profiling during drug discovery is a necessary process to confirm inhibitor selectivity and assess off-target activities. However, cost and logistical limitations prevent profiling activities from being performed in-house. We describe the development of an automated and flexible kinase profiling workflow that combines ready-to-use kinase enzymes and substrates in convenient eight-tube strips, a bench-top liquid handling device, ADP-Glo Kinase Assay (Promega, Madison, WI) technology to quantify enzyme activity, and a multimode detection instrument. Automated methods were developed for kinase reactions and quantification reactions to be assembled on a Gilson (Middleton, WI) PIPETMAX, following standardized plate layouts for single- and multidose compound profiling. Pipetting protocols were customized at runtime based on user-provided information, including compound number, increment for compound titrations, and number of kinase families to use. After the automated liquid handling procedures, a GloMax Discover (Promega) microplate reader preloaded with SMART protocols was used for luminescence detection and automatic data analysis. The functionality of the automated workflow was evaluated with several compound-kinase combinations in single-dose or dose-response profiling formats. Known target-specific inhibitions were confirmed. Novel small molecule-kinase interactions, including off-target inhibitions, were identified and confirmed in secondary studies. By adopting this streamlined profiling process, researchers can quickly and efficiently profile compounds of interest on site.

Materials management information systems.

PubMed

1996-01-01

The hospital materials management function--ensuring that goods and services get from a source to an end user--encompasses many areas of the hospital and can significantly affect hospital costs. Performing this function in a manner that will keep costs down and ensure adequate cash flow requires effective management of a large amount of information from a variety of sources. To effectively coordinate such information, most hospitals have implemented some form of materials management information system (MMIS). These systems can be used to automate or facilitate functions such as purchasing, accounting, inventory management, and patient supply charges. In this study, we evaluated seven MMISs from seven vendors, focusing on the functional capabilities of each system and the quality of the service and support provided by the vendor. This Evaluation is intended to (1) assist hospitals purchasing an MMIS by educating materials managers about the capabilities, benefits, and limitations of MMISs and (2) educate clinical engineers and information system managers about the scope of materials management within a healthcare facility. Because software products cannot be evaluated in the same manner as most devices typically included in Health Devices Evaluations, our standard Evaluation protocol was not applicable for this technology. Instead, we based our ratings on our observations (e.g., during site visits), interviews we conducted with current users of each system, and information provided by the vendor (e.g., in response to a request for information [RFI]). We divided the Evaluation into the following sections: Section 1. Responsibilities and Information Requirements of Materials Management: Provides an overview of typical materials management functions and describes the capabilities, benefits, and limitations of MMISs. Also includes the supplementary article, "Inventory Cost and Reimbursement Issues" and the glossary, "Materials Management Terminology." Section 2. The MMIS Selection Process: Outlines steps to follow and describes factors to consider when selecting an MMIS. Also includes our Materials Management Process Evaluation and Needs Assessment Worksheet (which is also available online through ECRInet(TM)) and a list of suggested interview questions to be used when gathering user experience information for systems under consideration. Section 3A. MMIS Vendor Profiles: Presents information for the evaluated systems in a standardized, easy-to-compare format. Profiles include an Executive Summary describing our findings, a discussion of user comments, a listing of MMIS specifications, and information on the vendor's business background. Section 3B. Discussion of Vendor Profile Conclusions and Ratings: Presents our ratings and summarizes our rationale for all evaluated systems. Also includes a blank Vendor Profile Template to be used when gathering information on other vendors and systems. We found that, in general, all of the evaluated systems are able to meet most of the functional needs of a materials management department. However, we did uncover significant differences in the quality of service and support provided by each vendor, and our ratings reflect these differences: we rated two of the systems Acceptable--Preferred and four of the systems Acceptable. We have not yet rated the seventh system because our user experience information may not reflect the vendor's new ownership and management. When this vendor provides the references we requested, we will interview users and supply a rating. We caution readers against basing purchasing decisions solely on our ratings. Each hospital must consider the unique needs of its users and its overall strategic plans--a process that can be aided by using our Process Evaluation and Needs Assessment Worksheet. Our conclusions can then be used to narrow down the number of vendors under consideration...

The potential of high-frequency profiling to assess vertical and seasonal patterns of phytoplankton dynamics in lakes: An extension of the Plankton Ecology Group (PEG) model

USGS Publications Warehouse

Brentrup, Jennifer A.; Williamson, Craig E.; Colom-Montero, William; Eckert, Werner; de Eyto, Elvira; Grossart, Hans-Peter; Huot, Yannick; Isles, Peter D. F.; Knoll, Lesley B.; Leach, Taylor H.; McBride, Christopher G.; Pierson, Don; Pomati, Francesco; Read, Jordan S.; Rose, Kevin C.; Samal, Nihar R.; Staehr, Peter A.; Winslow, Luke A.

2016-01-01

The use of high-frequency sensors on profiling buoys to investigate physical, chemical, and biological processes in lakes is increasing rapidly. Profiling buoys with automated winches and sensors that collect high-frequency chlorophyll fluorescence (ChlF) profiles in 11 lakes in the Global Lake Ecological Observatory Network (GLEON) allowed the study of the vertical and temporal distribution of ChlF, including the formation of subsurface chlorophyll maxima (SSCM). The effectiveness of 3 methods for sampling phytoplankton distributions in lakes, including (1) manual profiles, (2) single-depth buoys, and (3) profiling buoys were assessed. High-frequency ChlF surface data and profiles were compared to predictions from the Plankton Ecology Group (PEG) model. The depth-integrated ChlF dynamics measured by the profiling buoy data revealed a greater complexity that neither conventional sampling nor the generalized PEG model captured. Conventional sampling techniques would have missed SSCM in 7 of 11 study lakes. Although surface-only ChlF data underestimated average water column ChlF, at times by nearly 2-fold in 4 of the lakes, overall there was a remarkable similarity between surface and mean water column data. Contrary to the PEG model’s proposed negligible role for physical control of phytoplankton during the growing season, thermal structure and light availability were closely associated with ChlF seasonal depth distribution. Thus, an extension of the PEG model is proposed, with a new conceptual framework that explicitly includes physical metrics to better predict SSCM formation in lakes and highlight when profiling buoys are especially informative.

A perspective on two chemometrics tools: PCA and MCR, and introduction of a new one: Pattern recognition entropy (PRE), as applied to XPS and ToF-SIMS depth profiles of organic and inorganic materials

NASA Astrophysics Data System (ADS)

Chatterjee, Shiladitya; Singh, Bhupinder; Diwan, Anubhav; Lee, Zheng Rong; Engelhard, Mark H.; Terry, Jeff; Tolley, H. Dennis; Gallagher, Neal B.; Linford, Matthew R.

2018-03-01

X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are much used analytical techniques that provide information about the outermost atomic and molecular layers of materials. In this work, we discuss the application of multivariate spectral techniques, including principal component analysis (PCA) and multivariate curve resolution (MCR), to the analysis of XPS and ToF-SIMS depth profiles. Multivariate analyses often provide insight into data sets that is not easily obtained in a univariate fashion. Pattern recognition entropy (PRE), which has its roots in Shannon's information theory, is also introduced. This approach is not the same as the mutual information/entropy approaches sometimes used in data processing. A discussion of the theory of each technique is presented. PCA, MCR, and PRE are applied to four different data sets obtained from: a ToF-SIMS depth profile through ca. 100 nm of plasma polymerized C3F6 on Si, a ToF-SIMS depth profile through ca. 100 nm of plasma polymerized PNIPAM (poly (N-isopropylacrylamide)) on Si, an XPS depth profile through a film of SiO2 on Si, and an XPS depth profile through a film of Ta2O5 on Ta. PCA, MCR, and PRE reveal the presence of interfaces in the films, and often indicate that the first few scans in the depth profiles are different from those that follow. PRE and backward difference PRE provide this information in a straightforward fashion. Rises in the PRE signals at interfaces suggest greater complexity to the corresponding spectra. Results from PCA, especially for the higher principal components, were sometimes difficult to understand. MCR analyses were generally more interpretable.

Prevalence of stress references on college freshmen Facebook profiles.

PubMed

Egan, Katie G; Moreno, Megan A

2011-10-01

Stress is common among college students and associated with adverse health outcomes. This study used the social networking Web site Facebook to identify self-reported stress and associated conditions among college students. Public Facebook profiles of undergraduate freshman at a large Midwestern State University (n = 300) were identified using a Facebook search. Content analysis of Facebook profiles included demographic information and displayed references to stress, weight concerns, depressive symptoms, and alcohol. The mean reported age was 18.4 years, and the majority of profile owners were female (62%). Stress references were displayed on 37% of the profiles, weight concerns on 6%, depressive symptoms on 24%, and alcohol on 73%. The display of stress references was associated with female sex (odds ratio [OR], 2.81; confidence interval [CI], 1.7-4.7), weight concerns (OR, 5.36; CI, 1.87-15.34), and depressive symptoms (OR, 2.7; CI, 1.57-4.63). No associations were found between stress and alcohol references. College freshmen frequently display references to stress on Facebook profiles with prevalence rates similar to self-reported national survey data. Findings suggest a positive association between referencing stress and both weight concerns and depressive symptoms. Facebook may be a useful venue to identify students at risk for stress-related conditions and to disseminate information about campus resources to these students.

Highlights of TOMS Version 9 Total Ozone Algorithm

NASA Technical Reports Server (NTRS)

Bhartia, Pawan; Haffner, David

2012-01-01

The fundamental basis of TOMS total ozone algorithm was developed some 45 years ago by Dave and Mateer. It was designed to estimate total ozone from satellite measurements of the backscattered UV radiances at few discrete wavelengths in the Huggins ozone absorption band (310-340 nm). Over the years, as the need for higher accuracy in measuring total ozone from space has increased, several improvements to the basic algorithms have been made. They include: better correction for the effects of aerosols and clouds, an improved method to account for the variation in shape of ozone profiles with season, latitude, and total ozone, and a multi-wavelength correction for remaining profile shape errors. These improvements have made it possible to retrieve total ozone with just 3 spectral channels of moderate spectral resolution (approx. 1 nm) with accuracy comparable to state-of-the-art spectral fitting algorithms like DOAS that require high spectral resolution measurements at large number of wavelengths. One of the deficiencies of the TOMS algorithm has been that it doesn't provide an error estimate. This is a particular problem in high latitudes when the profile shape errors become significant and vary with latitude, season, total ozone, and instrument viewing geometry. The primary objective of the TOMS V9 algorithm is to account for these effects in estimating the error bars. This is done by a straightforward implementation of the Rodgers optimum estimation method using a priori ozone profiles and their error covariances matrices constructed using Aura MLS and ozonesonde data. The algorithm produces a vertical ozone profile that contains 1-2.5 pieces of information (degrees of freedom of signal) depending upon solar zenith angle (SZA). The profile is integrated to obtain the total column. We provide information that shows the altitude range in which the profile is best determined by the measurements. One can use this information in data assimilation and analysis. A side benefit of this algorithm is that it is considerably simpler than the present algorithm that uses a database of 1512 profiles to retrieve total ozone. These profiles are tedious to construct and modify. Though conceptually similar to the SBUV V8 algorithm that was developed about a decade ago, the SBUV and TOMS V9 algorithms differ in detail. The TOMS algorithm uses 3 wavelengths to retrieve the profile while the SBUV algorithm uses 6-9 wavelengths, so TOMS provides less profile information. However both algorithms have comparable total ozone information and TOMS V9 can be easily adapted to use additional wavelengths from instruments like GOME, OMI and OMPS to provide better profile information at smaller SZAs. The other significant difference between the two algorithms is that while the SBUV algorithm has been optimized for deriving monthly zonal means by making an appropriate choice of the a priori error covariance matrix, the TOMS algorithm has been optimized for tracking short-term variability using month and latitude dependent covariance matrices.

College Freshman with Disabilities, 1999: A Biennial Statistical Profile. Statistical Year 1998.

ERIC Educational Resources Information Center

Henderson, Cathy

This monograph presents information on college freshmen with disabilities based on data collected by the Cooperative Institutional Research Program, a longitudinal study of the American higher education system that includes 469 institutions and 275,811 students. Section 1 presents highlights of the 1998 freshman survey and includes personal and…

Expanded Croatian 12 X-STR loci database with an overview of anomalous profiles.

PubMed

Mršić, Gordan; Ozretić, Petar; Crnjac, Josip; Merkaš, Siniša; Sukser, Viktorija; Račić, Ivana; Rožić, Sara; Barbarić, Lucija; Popović, Maja; Korolija, Marina

2018-05-01

In order to implement X-chromosome short tandem repeat (X-STR) typing into routine forensic practice, reference database of a given population should be established. Therefore we extended already published data with additional 397 blood samples from unrelated Croatian citizens, and analyzed the total of 995 samples (549 male and 446 female) typed by Investigator ® Argus X-12 Kit. To test genetic homogeneity of consecutively processed five historic-cultural regions covering the entire national territory, we calculated pairwise Fst genetic distances between regions based on allele and full haplotype frequencies. Since the comparison did not yield any statistically significant difference, we integrated STR profile information from all regions and used the whole data set to calculate forensic parameters. The most informative marker is DXS10135 (polymorphism information content (PIC = 0.929) and the most informative linkage group (LG) is LG1 (PIC = 0.996). We confirmed linkage disequilibrium (LD) for seven marker pairs belonging to LG2, LG3 and LG4. By including LD information, we calculated cumulative power of discrimination that amounted to 0.999999999997 in females and 0.999999005 in males. We also compared Croatia with 13 European populations based on haplotype frequencies and detected no statistically significant Fst values after Bonferroni correction in any LG. Multi-dimensional scaling plot revealed tight grouping of four Croatian regions amongst populations of southern, central and northern Europe, with the exception of northern Croatia. In this study we gave the first extensive overview of aberrant profiles encountered during Investigator ® Argus X-12 typing. We found ten profiles consistent with single locus duplication followed by tetranucleotide tract length polymorphism. Locus DXS10079 is by far the most frequently affected one, presumably mutated in eight samples. We also found four profiles consistent with X-chromosome aneuploidy (three profiles with XXX pattern and one profile with XXY pattern). In conclusion, we established integral forensic Croatian X-chromosome database, proved forensic pertinence of Investigator ® Argus X-12 Kit for the entire Croatian population and identified locus DXS10079 as a potential duplication hotspot. Copyright © 2018 Elsevier B.V. All rights reserved.

Collaborative eHealth Meets Security: Privacy-Enhancing Patient Profile Management.

PubMed

Sanchez-Guerrero, Rosa; Mendoza, Florina Almenarez; Diaz-Sanchez, Daniel; Cabarcos, Patricia Arias; Lopez, Andres Marin

2017-11-01

Collaborative healthcare environments offer potential benefits, including enhancing the healthcare quality delivered to patients and reducing costs. As a direct consequence, sharing of electronic health records (EHRs) among healthcare providers has experienced a noteworthy growth in the last years, since it enables physicians to remotely monitor patients' health and enables individuals to manage their own health data more easily. However, these scenarios face significant challenges regarding security and privacy of the extremely sensitive information contained in EHRs. Thus, a flexible, efficient, and standards-based solution is indispensable to guarantee selective identity information disclosure and preserve patient's privacy. We propose a privacy-aware profile management approach that empowers the patient role, enabling him to bring together various healthcare providers as well as user-generated claims into an unique credential. User profiles are represented through an adaptive Merkle Tree, for which we formalize the underlying mathematical model. Furthermore, performance of the proposed solution is empirically validated through simulation experiments.

2015 Project Portfolio: Solid-State Lighting

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2015-01-30

Overview of SSL projects currently funded by DOE, and those previously funded but since completed. Each profile includes a brief technical description, as well as information about project partners, funding, and the research period. This report is updated annually.

TES Data and Information

Atmospheric Science Data Center

2018-03-20

... operates in both nadir and limb-sounding modes. TES global survey standard products include profile measurements of ozone, water vapor, ... for 16 orbits every other day. TES Special Observations are research measurements of targeted locations or regional transects which are ...

2017 Project Portfolio: Solid-State Lighting

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-01-02

Overview of SSL projects currently funded by DOE, and those previously funded but since completed. Each profile includes a brief technical description, as well as information about project partners, funding, and the research period. This report is updated annually.

Surgical lights. Making a purchase decision.

PubMed

Gregory, M M

1987-11-01

Based on the preceding factors, a profile can be made for each light. The profile should include the following information: product literature with detailed information about the light, the average score from each of the six categories on the questionnaire, a summary of positive and negative comments from the questionnaire (recurring comments can identify significant factors), recommendations from other hospitals using the light, warranty and service information and any pertinent information about the vendor and manufacturer, information or comments from the clinical engineer, the purchasing agent, and the architect/engineer, and information about possible purchase agreements. Once the profiles of the lights are finished, present them to the OR committee or group charged with making the final decision. The information will enable the group to compare the lights and will serve as a basis for either the final purchase or a detailed bid specification. If cost is a major factor in the decision, the evaluation results can be used to justify purchasing lights that are more expensive but that the users believe are clearly superior. This constitutes the "professional justification" that some government institutions require to circumvent regulations that require buying the low-bid product. Although the result of this selection process is clearly a subjective decision, it is an informed subjective decision. Once the lights are installed, the staff members' satisfaction with the lights will not be based on objective criteria but on the same subjective opinions that were used to justify the selection.

Low-flow profiles of the Tallapoosa River and tributaries in Georgia

USGS Publications Warehouse

Carter, R.F.; Hopkins, E.H.; Perlman, H.A.

1988-01-01

Low flow information is provided for use in an evaluation of the capacity of streams to permit withdrawals or to accept waste loads without exceeding the limits of State water quality standards. The report is the fourth in a series of reports presenting the results of a low flow study of all stream basins north of the Fall Line in Georgia. This report covers the part of the Tallapoosa River basin in the Piedmont province of Georgia. The low flow characteristic presented is the minimum average flow for 7 consecutive days with a 10-year recurrence interval (7Q10). The data are presented in tables and shown graphically as ' low flow profiles ' (low flow plotted against distance along a stream channel), and as ' drainage area profiles ' (drainage area plotted against distance along a stream channel). Low flow profiles were constructed by interpolation or extrapolation from points of known low flow data. Low flow profiles are included for all stream reaches where low flow data of sufficient accuracy are available to justify computation of the profiles. Drainage area profiles are included for all stream basins > 5 sq mi, except for those in a few remote areas. Flow records were not adjusted for diversions or other factors that cause measured flows to represent conditions other than natural flow. (Author 's abstract)

Development of an Air-Deployable Ocean Profiler

DTIC Science & Technology

2009-01-01

select the most appropriate technology for each component; sanity check that the selected technolgies can meet the design goals; and detailed...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources...gathering and maintaining the data needed, and completing and reviewing the collection of information . Send comments regarding this burden estimate

A Study of How Young Adults Leverage Multiple Profile Management Functionality in Managing Their Online Reputation on Social Networking Sites

ERIC Educational Resources Information Center

McCune, T. John

2017-01-01

With privacy settings on social networking sites (SNS) perceived as complex and difficult to use and maintain, young adults can be left vulnerable to others accessing and using their personal information. Consequences of not regulating the boundaries their information on SNS include the ability for current and future employers to make…

Some Instruments Used by Division 10, NDRC at Dugway Proving Ground for Continuous Recording of Micrometeorological Conditions

DTIC Science & Technology

1945-10-01

I. INTRODUCTION One of the original objectives of the NDRC Laboratory at Dugwoy Proving Ground was to study and assess the effect of...the results of the experiment should include information from more than one looation on the target, or else a study at one location of the varia...forecasts or in other micrometeorologioal studies . In addition it has proved useful in measurements on wind profiles« temperature profiles, and

Older adolescents' views regarding participation in Facebook research.

PubMed

Moreno, Megan A; Grant, Alison; Kacvinsky, Lauren; Moreno, Peter; Fleming, Michael

2012-11-01

Facebook continues to grow in popularity among adolescents as well as adolescent researchers. Guidance on conducting research using Facebook with appropriate attention to privacy and ethics is scarce. To inform such research efforts, the purpose of this study was to determine older adolescents' responses after learning that they were participants in a research study that involved identification of participants using Facebook. Public Facebook profiles of older adolescents aged 18-19 years from a large state university were examined. Profile owners were then interviewed. During the interview, participants were informed that they were identified by examining publicly available Facebook profiles. Participants were asked to discuss their views on this research method. A total of 132 participants completed the interview (70% response rate); the average age was 18.4 years (SD = .5); and our sample included 64 male participants (48.5%). Participant responses included endorsement (19.7%), fine (36.4%), neutral (28.8%), uneasy (9.1%), and concerned (6.1%). Among participants who were uneasy or concerned, the majority voiced confusion regarding their current profile security settings (p = .00). The majority of adolescent participants viewed the use of Facebook for research positively. These findings are consistent with the approach taken by many U.S. courts. Researchers may consider these findings when developing research protocols involving Facebook. Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Expression profiling of the mouse early embryo: Reflections and Perspectives

PubMed Central

Ko, Minoru S. H.

2008-01-01

Laboratory mouse plays important role in our understanding of early mammalian development and provides invaluable model for human early embryos, which are difficult to study for ethical and technical reasons. Comprehensive collection of cDNA clones, their sequences, and complete genome sequence information, which have been accumulated over last two decades, have provided even more advantages to mouse models. Here the progress in global gene expression profiling in early mouse embryos and, to some extent, stem cells are reviewed and the future directions and challenges are discussed. The discussions include the restatement of global gene expression profiles as snapshot of cellular status, and subsequent distinction between the differentiation state and physiological state of the cells. The discussions then extend to the biological problems that can be addressed only through global expression profiling, which include: bird’s-eye view of global gene expression changes, molecular index for developmental potency, cell lineage trajectory, microarray-guided cell manipulation, and the possibility of delineating gene regulatory cascades and networks. PMID:16739220

A Methodology to Seperate and Analyze a Seismic Wide Angle Profile

NASA Astrophysics Data System (ADS)

Weinzierl, Wolfgang; Kopp, Heidrun

2010-05-01

General solutions of inverse problems can often be obtained through the introduction of probability distributions to sample the model space. We present a simple approach of defining an a priori space in a tomographic study and retrieve the velocity-depth posterior distribution by a Monte Carlo method. Utilizing a fitting routine designed for very low statistics to setup and analyze the obtained tomography results, it is possible to statistically separate the velocity-depth model space derived from the inversion of seismic refraction data. An example of a profile acquired in the Lesser Antilles subduction zone reveals the effectiveness of this approach. The resolution analysis of the structural heterogeneity includes a divergence analysis which proves to be capable of dissecting long wide-angle profiles for deep crust and upper mantle studies. The complete information of any parameterised physical system is contained in the a posteriori distribution. Methods for analyzing and displaying key properties of the a posteriori distributions of highly nonlinear inverse problems are therefore essential in the scope of any interpretation. From this study we infer several conclusions concerning the interpretation of the tomographic approach. By calculating a global as well as singular misfits of velocities we are able to map different geological units along a profile. Comparing velocity distributions with the result of a tomographic inversion along the profile we can mimic the subsurface structures in their extent and composition. The possibility of gaining a priori information for seismic refraction analysis by a simple solution to an inverse problem and subsequent resolution of structural heterogeneities through a divergence analysis is a new and simple way of defining a priori space and estimating the a posteriori mean and covariance in singular and general form. The major advantage of a Monte Carlo based approach in our case study is the obtained knowledge of velocity depth distributions. Certainly the decision of where to extract velocity information on the profile for setting up a Monte Carlo ensemble is limiting the a priori space. However, the general conclusion of analyzing the velocity field according to distinct reference distributions gives us the possibility to define the covariance according to any geological unit if we have a priori information on the velocity depth distributions. Using the wide angle data recorded across the Lesser Antilles arc, we are able to resolve a shallow feature like the backstop by a robust and simple divergence analysis. We demonstrate the effectiveness of the new methodology to extract some key features and properties from the inversion results by including information concerning the confidence level of results.

Healthcare managers' leadership profiles in relation to perceptions of work stressors and stress.

PubMed

Lornudd, Caroline; Bergman, David; Sandahl, Christer; von Thiele Schwarz, Ulrica

2016-05-03

Purpose The purpose of this study is to investigate the relationship between leadership profiles and differences in managers' own levels of work stress symptoms and perceptions of work stressors causing stress. Design/methodology/approach Cross-sectional data were used. Healthcare managers ( n = 188) rated three dimensions of their leadership behavior and levels of work stressors and stress. Hierarchical cluster analysis was performed to identify leadership profiles based on leadership behaviors. Differences in stress-related outcomes between profiles were assessed using one-way analysis of variance. Findings Four distinct clusters of leadership profiles were found. They discriminated in perception of work stressors and stress: the profile distinguished by the lowest mean in all behavior dimensions, exhibited a pattern with significantly more negative ratings compared to the other profiles. Practical implications This paper proposes that leadership profile is an individual factor involved in the stress process, including work stressors and stress, which may inform targeted health promoting interventions for healthcare managers. Originality/value This is the first study to investigate the relationship between leadership profiles and work stressors and stress in healthcare managers.

Profiling a Periodicals Collection

ERIC Educational Resources Information Center

Bolgiano, Christina E.; King, Mary Kathryn

1978-01-01

Libraries need solid information upon which to base collection development decisions. Specific evaluative methods for determining scope, access, and usefullness are described. Approaches used for data collection include analysis of interlibrary loan requests, comparison with major bibliographies, and analysis of accessibility through available…

Information Theory Broadens the Spectrum of Molecular Ecology and Evolution.

PubMed

Sherwin, W B; Chao, A; Jost, L; Smouse, P E

2017-12-01

Information or entropy analysis of diversity is used extensively in community ecology, and has recently been exploited for prediction and analysis in molecular ecology and evolution. Information measures belong to a spectrum (or q profile) of measures whose contrasting properties provide a rich summary of diversity, including allelic richness (q=0), Shannon information (q=1), and heterozygosity (q=2). We present the merits of information measures for describing and forecasting molecular variation within and among groups, comparing forecasts with data, and evaluating underlying processes such as dispersal. Importantly, information measures directly link causal processes and divergence outcomes, have straightforward relationship to allele frequency differences (including monotonicity that q=2 lacks), and show additivity across hierarchical layers such as ecology, behaviour, cellular processes, and nongenetic inheritance. Copyright © 2017 Elsevier Ltd. All rights reserved.

Motion tracking in MR-guided liver therapy by using navigator echoes and projection profile matching.

PubMed

Tokuda, Junichi; Morikawa, Shigehiro; Dohi, Takeyoshi; Hata, Nobuhiko

2004-01-01

Image registration in magnetic resonance (MR) image-guided liver therapy enhances surgical guidance by fusing preoperative multimodality images with intraoperative images, or by fusing intramodality images to correlate serial intraoperative images to monitor the effect of therapy. The objective of this paper is to describe the application of navigator echo and projection profile matching to fast two-dimensional image registration for MR-guided liver therapy. We obtain navigator echoes along the read-out and phase-encoding directions by using modified gradient echo imaging. This registration is made possible by masking out the liver profile from the image and performing profile matching with cross-correlation or mutual information as similarity measures. The set of experiments include a phantom study with a 2.0-T experimental MR scanner, and a volunteer and a clinical study with a 0.5-T open-configuration MR scanner, and these evaluate the accuracy and effectiveness of this method for liver therapy. Both the phantom and volunteer study indicate that this method can perform registration in 34 ms with root-mean-square error of 1.6 mm when the given misalignment of a liver is 30 mm. The clinical studies demonstrate that the method can track liver motion of up to approximately 40 mm. Matching profiles with cross-correlation information perform better than with mutual information in terms of robustness and speed. The proposed image registration method has potential clinical impact on and advantages for MR-guided liver therapy.

Total Solar Eclipse of 2008 August 01

NASA Technical Reports Server (NTRS)

Espenak, F.; Anderson, J.

2007-01-01

On 2008 August 01, a total eclipse of the Sun is visible from within a narrow corridor that traverses half the Earth. The path of the Moon's umbral shadow begins in northern Canada and extends across Greenland, the Arctic, central Russia, Mongolia, and China. A partial eclipse is seen within the much broader path of the Moon's penumbral shadow, which includes northeastern North America, most of Europe and Asia. Detailed predictions for this event are presented and include besselian elements, geographic coordinates of the path of totality, physical ephemeris of the umbra, topocentric limb profile corrections, local circumstances for 308 cities, maps of the eclipse path, weather prospects, the lunar limb profile and the sky during totality. Information on safe eclipse viewing and eclipse photography is included.

From ontology selection and semantic web to an integrated information system for food-borne diseases and food safety.

PubMed

Yan, Xianghe; Peng, Yun; Meng, Jianghong; Ruzante, Juliana; Fratamico, Pina M; Huang, Lihan; Juneja, Vijay; Needleman, David S

2011-01-01

Several factors have hindered effective use of information and resources related to food safety due to inconsistency among semantically heterogeneous data resources, lack of knowledge on profiling of food-borne pathogens, and knowledge gaps among research communities, government risk assessors/managers, and end-users of the information. This paper discusses technical aspects in the establishment of a comprehensive food safety information system consisting of the following steps: (a) computational collection and compiling publicly available information, including published pathogen genomic, proteomic, and metabolomic data; (b) development of ontology libraries on food-borne pathogens and design automatic algorithms with formal inference and fuzzy and probabilistic reasoning to address the consistency and accuracy of distributed information resources (e.g., PulseNet, FoodNet, OutbreakNet, PubMed, NCBI, EMBL, and other online genetic databases and information); (c) integration of collected pathogen profiling data, Foodrisk.org ( http://www.foodrisk.org ), PMP, Combase, and other relevant information into a user-friendly, searchable, "homogeneous" information system available to scientists in academia, the food industry, and government agencies; and (d) development of a computational model in semantic web for greater adaptability and robustness.

Effects of Mean Flow Profiles on Instability of a Low-Density Gas Jet Injected into a High-Density Gas

NASA Technical Reports Server (NTRS)

Vedantam, Nanda Kishore

2003-01-01

The objective of this study was to investigate the effects of the mean flow profiles on the instability characteristics in the near-injector region of low-density gas jets injected into high-density ambient gas mediums. To achieve this, a linear temporal stability analysis and a spatio-temporal stability analysis of a low-density round gas jet injected vertically upwards into a high-density ambient gas were performed by assuming three different sets of mean velocity and density profiles. The flow was assumed to be isothermal and locally parallel. Viscous and diffusive effects were ignored. The mean flow parameters were represented as the sum of the mean value and a small normal-mode fluctuation. A second order differential equation governing the pressure disturbance amplitude was derived from the basic conservation equations. The first set of mean velocity and density profiles assumed were those used by Monkewitz and Sohn for investigating absolute instability in hot jets. The second set of velocity and density profiles assumed for this study were the ones used by Lawson. And the third set of mean profiles included a parabolic velocity profile and a hyperbolic tangent density profile. The effects of the inhomogeneous shear layer and the Froude number (signifying the effects of gravity) on the temporal and spatio-temporal results for each set of mean profiles were delineated. Additional information is included in the original extended abstract.

What's on YOUR Facebook profile? Evaluation of an educational intervention to promote appropriate use of privacy settings by medical students on social networking sites.

PubMed

Walton, Jennifer M; White, Jonathan; Ross, Shelley

2015-01-01

Background The rise of social media has led to growing concerns about the potential implications of 'unprofessional' postings by physicians and medical students on individuals, institutions, and the medical profession. Relevant and effective guidelines have been difficult to develop and enforce, and there is a need for students and physicians to consider how their online activities may be perceived in the context of their professional roles. The purpose of this project was to examine the Internet presence of a graduating Canadian medical school class by scanning students' public profiles on the social media site Facebook, incorporate this information into an educational activity addressing professionalism and social media, and evaluate the impact of this activity on student behavior. Methods A systematic search for public Facebook profiles of each member of the class was conducted, and data were collected on the types of publicly visible material. These were presented as part of an educational session on social media and professionalism. One month later, the Facebook search was repeated. Results Of 152 students in the class, profiles were found for 121 (79.8%). The majority of students used appropriately restrictive privacy settings; however, a significant minority had publicly visible information, including comments, photographs, location, and status as a medical student. The educational innovation was well received with more than 90% of students agreeing that this topic was important and well addressed. A follow-up search found that many students had altered their privacy settings to make less information publicly available. Conclusions A small but significant proportion of students share potentially unprofessional content on social media. An interactive educational intervention, which includes specific disclosure of how participants appear to others on social media, resulted in a significant change in student behavior.

What's on YOUR Facebook profile? Evaluation of an educational intervention to promote appropriate use of privacy settings by medical students on social networking sites.

PubMed

Walton, Jennifer M; White, Jonathan; Ross, Shelley

2015-01-01

The rise of social media has led to growing concerns about the potential implications of 'unprofessional' postings by physicians and medical students on individuals, institutions, and the medical profession. Relevant and effective guidelines have been difficult to develop and enforce, and there is a need for students and physicians to consider how their online activities may be perceived in the context of their professional roles. The purpose of this project was to examine the Internet presence of a graduating Canadian medical school class by scanning students' public profiles on the social media site Facebook, incorporate this information into an educational activity addressing professionalism and social media, and evaluate the impact of this activity on student behavior. A systematic search for public Facebook profiles of each member of the class was conducted, and data were collected on the types of publicly visible material. These were presented as part of an educational session on social media and professionalism. One month later, the Facebook search was repeated. Of 152 students in the class, profiles were found for 121 (79.8%). The majority of students used appropriately restrictive privacy settings; however, a significant minority had publicly visible information, including comments, photographs, location, and status as a medical student. The educational innovation was well received with more than 90% of students agreeing that this topic was important and well addressed. A follow-up search found that many students had altered their privacy settings to make less information publicly available. A small but significant proportion of students share potentially unprofessional content on social media. An interactive educational intervention, which includes specific disclosure of how participants appear to others on social media, resulted in a significant change in student behavior.

MULTIMEDIA ENVIRONMENTAL DISTRIBUTION OF TOXICS (MEND-TOX): PART II, SOFTWARE IMPLEMENTATION AND CASE STUDIES

EPA Science Inventory

An integrated hybrid spatial-compartmental simulator is presented for analyzing the dynamic distribution of chemicals in the multimedia environment. Information obtained from such analysis, which includes temporal chemical concentration profiles in various media, mass distribu...

MULTIMEDIA ENVIRONMENTAL DISTRIBUTION OF TOXICS (MEND-TOX): PART I, HYBRID COMPARTMENTAL-SPATIAL MODELING FRAMEWORK

EPA Science Inventory

An integrated hybrid spatial-compartmental modeling approach is presented for analyzing the dynamic distribution of chemicals in the multimedia environment. Information obtained from such analysis, which includes temporal chemical concentration profiles in various media, mass ...

Combating Transnational Organized Crime: Strategies and Metrics for the Threat

DTIC Science & Technology

2012-05-01

TOC to facilitate weapons of mass destruction (WMD). 2. Use open source intelligence ( OSINT ) sources to develop profiles of individuals and...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources ...Government. All information and sources for this paper were drawn from unclassified materials. Samuel Musa is a Senior Research Fellow at the Center

Social network utilization (Facebook) & e-Professionalism among medical students.

PubMed

Jawaid, Masood; Khan, Muhammad Hassaan; Bhutto, Shahzadi Nisar

2015-01-01

To find out the frequency and contents of online social networking (Facebook) among medical students of Dow University of Health Sciences. The sample of the study comprised of final year students of two medical colleges of Dow University of Health Sciences - Karachi. Systematic search for the face book profiles of the students was carried out with a new Facebook account. In the initial phase of search, it was determined whether each student had a Facebook account and the status of account as ''private'' ''intermediate'' or ''public'' was also sought. In the second phase of the study, objective information including gender, education, personal views, likes, tag pictures etc. were recorded for the publicly available accounts. An in depth qualitative content analysis of the public profiles of ten medical students, selected randomly with the help of random number generator technique was conducted. Social networking with Facebook is common among medical students with 66.9% having an account out of a total 535 students. One fifth of profiles 18.9% were publicly open, 36.6% profiles were private and 56.9% were identified to have an intermediate privacy setting, having customized settings for the profile information. In-depth analysis of some public profiles showed that potentially unprofessional material mostly related to violence and politics was posted by medical students. The usage of social network (Facebook) is very common among students of the university. Some unprofessional posts were also found on students' profiles mostly related to violence and politics.

Prevalence of Stress References on College Freshmen Facebook Profiles

PubMed Central

EGAN, KATIE G.; MORENO, MEGAN A.

2011-01-01

Stress is common among college students and associated with adverse health outcomes. This study used the social networking Web site Facebook to identify self-reported stress and associated conditions among college students. Public Facebook profiles of undergraduate freshman at a large Midwestern State University (n = 300) were identified using a Facebook search. Content analysis of Facebook profiles included demographic information and displayed references to stress, weight concerns, depressive symptoms, and alcohol. The mean reported age was 18.4 years, and the majority of profile owners were female (62%). Stress references were displayed on 37% of the profiles, weight concerns on 6%, depressive symptoms on 24%, and alcohol on 73%. The display of stress references was associated with female sex (odds ratio [OR], 2.81; confidence interval [CI], 1.7–4.7), weight concerns (OR, 5.36; CI, 1.87–15.34), and depressive symptoms (OR, 2.7; CI, 1.57–4.63). No associations were found between stress and alcohol references. College freshmen frequently display references to stress on Facebook profiles with prevalence rates similar to self-reported national survey data. Findings suggest a positive association between referencing stress and both weight concerns and depressive symptoms. Facebook may be a useful venue to identify students at risk for stress-related conditions and to disseminate information about campus resources to these students. PMID:21436681

Raster profile development for the spatial data transfer standard

USGS Publications Warehouse

Szemraj, John A.

1993-01-01

The Spatial Data Transfer Standard (SDTS), recently approved as Federal Information Processing Standard (FIPS) Publication 173, is designed to transfer various types of spatial data. Implementing all of the standard's options at one time is impractical. Profiles, or limited subsets of the SDTS, are the mechanisms by which the standards will be implemented. The development of a raster profile is being coordinated by the U.S. Geological Survey's (USGS) SDTS Task Force. This raster profile is intended to accommodate digital georeferenced image data and regularly spaces, georeferenced gridded data. The USGS's digital elevation models (DEMs) and digital orthophoto quadrangles (DOQs), National Oceanic and Atmospheric Administration's (NOAA) advanced very huh resolution radiometer (AVHRR) and Landsat data, and National Aeronautics and Space Administration's (NASA) Earth observing system (EOS) data are among the candidate data sets for this profile. Other raster profiles, designed to support nongeoreferenced and other types of "raw" sensor data will be consider in the future. As with the Topological Vector Profile (TVP) for the SDTS, development of the raster profile includes designing a prototype profile, testing the prototype profile using sample data sets, and finally, requesting and receiving FIPS approval.

Applications of the LBA-ECO Metadata Warehouse

NASA Astrophysics Data System (ADS)

Wilcox, L.; Morrell, A.; Griffith, P. C.

2006-05-01

The LBA-ECO Project Office has developed a system to harvest and warehouse metadata resulting from the Large-Scale Biosphere Atmosphere Experiment in Amazonia. The harvested metadata is used to create dynamically generated reports, available at www.lbaeco.org, which facilitate access to LBA-ECO datasets. The reports are generated for specific controlled vocabulary terms (such as an investigation team or a geospatial region), and are cross-linked with one another via these terms. This approach creates a rich contextual framework enabling researchers to find datasets relevant to their research. It maximizes data discovery by association and provides a greater understanding of the scientific and social context of each dataset. For example, our website provides a profile (e.g. participants, abstract(s), study sites, and publications) for each LBA-ECO investigation. Linked from each profile is a list of associated registered dataset titles, each of which link to a dataset profile that describes the metadata in a user-friendly way. The dataset profiles are generated from the harvested metadata, and are cross-linked with associated reports via controlled vocabulary terms such as geospatial region. The region name appears on the dataset profile as a hyperlinked term. When researchers click on this link, they find a list of reports relevant to that region, including a list of dataset titles associated with that region. Each dataset title in this list is hyperlinked to its corresponding dataset profile. Moreover, each dataset profile contains hyperlinks to each associated data file at its home data repository and to publications that have used the dataset. We also use the harvested metadata in administrative applications to assist quality assurance efforts. These include processes to check for broken hyperlinks to data files, automated emails that inform our administrators when critical metadata fields are updated, dynamically generated reports of metadata records that link to datasets with questionable file formats, and dynamically generated region/site coordinate quality assurance reports. These applications are as important as those that facilitate access to information because they help ensure a high standard of quality for the information. This presentation will discuss reports currently in use, provide a technical overview of the system, and discuss plans to extend this system to harvest metadata resulting from the North American Carbon Program by drawing on datasets in many different formats, residing in many thematic data centers and also distributed among hundreds of investigators.

Reliability of a computer and Internet survey (Computer User Profile) used by adults with and without traumatic brain injury (TBI).

PubMed

Kilov, Andrea M; Togher, Leanne; Power, Emma

2015-01-01

To determine test-re-test reliability of the 'Computer User Profile' (CUP) in people with and without TBI. The CUP was administered on two occasions to people with and without TBI. The CUP investigated the nature and frequency of participants' computer and Internet use. Intra-class correlation coefficients and kappa coefficients were conducted to measure reliability of individual CUP items. Descriptive statistics were used to summarize content of responses. Sixteen adults with TBI and 40 adults without TBI were included in the study. All participants were reliable in reporting demographic information, frequency of social communication and leisure activities and computer/Internet habits and usage. Adults with TBI were reliable in 77% of their responses to survey items. Adults without TBI were reliable in 88% of their responses to survey items. The CUP was practical and valuable in capturing information about social, leisure, communication and computer/Internet habits of people with and without TBI. Adults without TBI scored more items with satisfactory reliability overall in their surveys. Future studies may include larger samples and could also include an exploration of how people with/without TBI use other digital communication technologies. This may provide further information on determining technology readiness for people with TBI in therapy programmes.

An update to the toxicological profile for water-soluble and sparingly soluble tungsten substances

PubMed Central

Lemus, Ranulfo; Venezia, Carmen F.

2015-01-01

Abstract Tungsten is a relatively rare metal with numerous applications, most notably in machine tools, catalysts, and superalloys. In 2003, tungsten was nominated for study under the National Toxicology Program, and in 2011, it was nominated for human health assessment under the US Environmental Protection Agency's (EPA) Integrated Risk Information System. In 2005, the Agency for Toxic Substances and Disease Registry (ATSDR) issued a toxicological profile for tungsten, identifying several data gaps in the hazard assessment of tungsten. By filling the data gaps identified by the ATSDR, this review serves as an update to the toxicological profile for tungsten and tungsten substances. A PubMed literature search was conducted to identify reports published during the period 2004–2014, in order to gather relevant information related to tungsten toxicity. Additional information was also obtained directly from unpublished studies from within the tungsten industry. A systematic approach to evaluate the quality of data was conducted according to published criteria. This comprehensive review has gathered new toxicokinetic information and summarizes the details of acute and repeated-exposure studies that include reproductive, developmental, neurotoxicological, and immunotoxicological endpoints. Such new evidence involves several relevant studies that must be considered when regulators estimate and propose a tungsten reference or concentration dose. PMID:25695728

Social networking profile correlates of schizotypy.

PubMed

Martin, Elizabeth A; Bailey, Drew H; Cicero, David C; Kerns, John G

2012-12-30

Social networking sites, such as Facebook, are extremely popular and have become a primary method for socialization and communication. Despite a report of increased use among those on the schizophrenia-spectrum, few details are known about their actual practices. In the current research, undergraduate participants completed measures of schizotypy and personality, and provided access to their Facebook profiles. Information from the profiles were then systematically coded and compared to the questionnaire data. As predicted, social anhedonia (SocAnh) was associated with a decrease in social participation variables, including a decrease in number of friends and number of photos, and an increase in length of time since communication with a friend, but SocAnh was also associated with an increase in profile length. Also, SocAnh was highly correlated with extraversion. Relatedly, extraversion uniquely predicted the number of friends and photos and length of time since communication with a friend. In addition, perceptual aberration/magical ideation (PerMag) was associated with an increased number of "black outs" on Facebook profile print-outs, a measure of paranoia. Overall, results from this naturalistic-like study show that SocAnh and extraversion are associated with decreased social participation and PerMag with increased paranoia related to information on social networking sites. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Social networking profile correlates of schizotypy

PubMed Central

Martin, Elizabeth A.; Bailey, Drew H.; Cicero, David C.; Kerns, John G.

2015-01-01

Social networking sites, such as Facebook, are extremely popular and have become a primary method for socialization and communication. Despite a report of increased use among those on the schizophrenia-spectrum, few details are known about their actual practices. In the current research, undergraduate participants completed measures of schizotypy and personality, and provided access to their Facebook profiles. Information from the profiles were then systematically coded and compared to the questionnaire data. As predicted, social anhedonia (SocAnh) was associated with a decrease in social participation variables, including a decrease in number of friends and number of photos, and an increase in length of time since communication with a friend, but SocAnh was also associated with an increase in profile length. Also, SocAnh was highly correlated with extraversion. Relatedly, extraversion uniquely predicted the number of friends and photos and length of time since communication with a friend. In addition, perceptual aberration/magical ideation (PerMag) was associated with an increased number of “black outs” on Facebook profile print-outs, a measure of paranoia. Overall, results from this naturalistic-like study show that SocAnh and extraversion are associated with decreased social participation and PerMag with increased paranoia related to information on social networking sites. PMID:22796101

Direct characterization of commercial lecithins by easy ambient sonic-spray ionization mass spectrometry.

PubMed

Fernandes, Gabriel D; Alberici, Rosana M; Pereira, Gustavo G; Cabral, Elaine C; Eberlin, Marcos N; Barrera-Arellano, Daniel

2012-12-01

Commercial lecithins are composed mainly of phospholipids and triacylglycerols. The analysis of the commercial lecithins, including their fraction of phospholipids, normally involves laborious and expensive protocols. Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to be an efficient technique for the analysis of lipids. Samples of commercial lecithins including standards, refined, deoiled and modified soy lecithin were tested. Characteristic profiles of phosphatidylcholines and triacylglycerols are detected by EASI(+)-MS, whereas EASI(-)-MS provided phosphatidylethanolamines, glycophospholipids and free fatty acids profiles. Acetylated lecithins also displayed characteristic acetylated derivatives. EASI-MS data was also compared to MALDI-MS, and found to display richer compositional information. The industrial process applied to lecithin fabrication was also characterised via typical EASI-MS profiles. EASI-MS both in its positive and negative ion modes offers a direct, fast and efficient technique able to characterise commercial lecithin. Copyright © 2012 Elsevier Ltd. All rights reserved.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding.

PubMed

Shahi, Payam; Kim, Samuel C; Haliburton, John R; Gartner, Zev J; Abate, Adam R

2017-03-14

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding

NASA Astrophysics Data System (ADS)

Shahi, Payam; Kim, Samuel C.; Haliburton, John R.; Gartner, Zev J.; Abate, Adam R.

2017-03-01

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding

PubMed Central

Shahi, Payam; Kim, Samuel C.; Haliburton, John R.; Gartner, Zev J.; Abate, Adam R.

2017-01-01

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing. PMID:28290550

Combined Volatolomics for Monitoring of Human Body Chemistry

PubMed Central

Broza, Yoav Y.; Zuri, Liat; Haick, Hossam

2014-01-01

Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanomaterial-based sensors array, we demonstrate that simultaneous VOC detection from breath and skin would provide complementary, non-correlated information of the body's volatile metabolites profile. Eventually with further wide population validation studies, such a methodology could provide more accurate monitoring of pathological changes compared to the information provided by a single body fluid. The qualitative and quantitative methods presented here offers a variety of options for novel mapping of the metabolic properties of complex organisms, including humans. PMID:24714440

Combined volatolomics for monitoring of human body chemistry.

PubMed

Broza, Yoav Y; Zuri, Liat; Haick, Hossam

2014-04-09

Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanomaterial-based sensors array, we demonstrate that simultaneous VOC detection from breath and skin would provide complementary, non-correlated information of the body's volatile metabolites profile. Eventually with further wide population validation studies, such a methodology could provide more accurate monitoring of pathological changes compared to the information provided by a single body fluid. The qualitative and quantitative methods presented here offers a variety of options for novel mapping of the metabolic properties of complex organisms, including humans.

Utilization of satellite imagery by in-flight aircraft. [for weather information

NASA Technical Reports Server (NTRS)

Luers, J. K.

1976-01-01

Present and future utilization of satellite weather data by commercial aircraft while in flight was assessed. Weather information of interest to aviation that is available or will become available with future geostationary satellites includes the following: severe weather areas, jet stream location, weather observation at destination airport, fog areas, and vertical temperature profiles. Utilization of this information by in-flight aircraft is especially beneficial for flights over the oceans or over remote land areas where surface-based observations and communications are sparse and inadequate.

ISS Expedition 42 Crew Profile, Version 2

NASA Image and Video Library

2014-11-26

Narrated production with biographical information about ISS Expedition 42 crewmembers Barry "Butch" Wilmore, Alexander Samokutyaev, Elena Serova, Terry Virts, Anton Shkaplerov and Samantha Cristoforetti. The program covers the crewmember's career including childhood photographs, previous space missions and interview sound bites with the crewmembers.

Fundamentals of Welding. Teacher Edition.

ERIC Educational Resources Information Center

Fortney, Clarence; And Others

These instructional materials assist teachers in improving instruction on the fundamentals of welding. The following introductory information is included: use of this publication; competency profile; instructional/task analysis; related academic and workplace skills list; tools, materials, and equipment list; and 27 references. Seven units of…

Development of a Dynamic Traffic Assignment Model for Northern Nevada

DOT National Transportation Integrated Search

2014-06-01

The objective of this research is to build and calibrate a DTA model for Northern Nevada (RenoSparks Area) based on the network profile and travel demand information updated to date. The critical procedures include development of consistent and readi...

Flying High.

ERIC Educational Resources Information Center

Sherman, Lee; Paglin, Catherine; Jarrett, Denise; Kneidek, Tony

1998-01-01

Profiles 10 technology-based programs in Montana, Oregon, Washington, Alaska, and Idaho schools that use computers, the Internet, and multimedia to teach math, science, information skills, economics, English, history, and graphic design. Includes teacher comments on hardware, software, costs, the changing role of the teacher, Internet safety, and…

NASA Tech Briefs, March 1998. Volume 22, No. 3

NASA Technical Reports Server (NTRS)

1998-01-01

Topics include: special coverage of computer aided design and engineering, electronic components and circuits, electronic systems, physical sciences, materials, computer software, special coverage on mechanical technology, machinery/automation, manufacturing/fabrication, mathematics and information sciences, book and reports, and a special section of Electronics Tech Briefs. Profiles of the exhibitors at the National Design Engineering show are also included in this issue.

Supporting the Loewenstein occupational therapy cognitive assessment using distributed user interfaces.

PubMed

Tesoriero, Ricardo; Gallud Lazaro, Jose A; Altalhi, Abdulrahman H

2017-02-01

Improve the quantity and quality of information obtained from traditional Loewenstein Occupational Therapy Cognitive Assessment Battery systems to monitor the evolution of patients' rehabilitation process as well as to compare different rehabilitation therapies. The system replaces traditional artefacts with virtual versions of them to take advantage of cutting edge interaction technology. The system is defined as a Distributed User Interface (DUI) supported by a display ecosystem, including mobile devices as well as multi-touch surfaces. Due to the heterogeneity of the devices involved in the system, the software technology is based on a client-server architecture using the Web as the software platform. The system provides therapists with information that is not available (or it is very difficult to gather) using traditional technologies (i.e. response time measurements, object tracking, information storage and retrieval facilities, etc.). The use of DUIs allows therapists to gather information that is unavailable using traditional assessment methods as well as adapt the system to patients' profile to increase the range of patients that are able to take this assessment. Implications for Rehabilitation Using a Distributed User Interface environment to carry out LOTCAs improves the quality of the information gathered during the rehabilitation assessment. This system captures physical data regarding patient's interaction during the assessment to improve the rehabilitation process analysis. Allows professionals to adapt the assessment procedure to create different versions according to patients' profile. Improves the availability of patients' profile information to therapists to adapt the assessment procedure.

A Study on the Secure User Profiling Structure and Procedure for Home Healthcare Systems.

PubMed

Ko, Hoon; Song, MoonBae

2016-01-01

Despite of various benefits such as a convenience and efficiency, home healthcare systems have some inherent security risks that may cause a serious leak on personal health information. This work presents a Secure User Profiling Structure which has the patient information including their health information. A patient and a hospital keep it at that same time, they share the updated data. While they share the data and communicate, the data can be leaked. To solve the security problems, a secure communication channel with a hash function and an One-Time Password between a client and a hospital should be established and to generate an input value to an OTP, it uses a dual hash-function. This work presents a dual hash function-based approach to generate the One-Time Password ensuring a secure communication channel with the secured key. In result, attackers are unable to decrypt the leaked information because of the secured key; in addition, the proposed method outperforms the existing methods in terms of computation cost.

Qualitative and quantitative aspects of information processing in first psychosis: latent class analyses in patients, at-risk subjects, and controls.

PubMed

van Tricht, Mirjam J; Bour, Lo J; Koelman, Johannes H T M; Derks, Eske M; Braff, David L; de Wilde, Odette M; Boerée, Thijs; Linszen, Don H; de Haan, Lieuwe; Nieman, Dorien H

2015-04-01

We aimed to determine profiles of information processing deficits in the pathway to first psychosis. Sixty-one subjects at ultrahigh risk (UHR) for psychosis were assessed, of whom 18 converted to a first episode of psychosis (FEP) within the follow-up period. Additionally, 47 FEP and 30 control subjects were included. Using 10 neurophysiological parameters associated with information processing, latent class analyses yielded three classes at baseline. Class membership was related to group status. Within the UHR sample, two classes were found. Transition to psychosis was nominally associated with class membership. Neurophysiological profiles were unstable over time, but associations between specific neurophysiological components at baseline and follow-up were found. We conclude that certain constellations of neurophysiological variables aid in the differentiation between controls and patients in the prodrome and after first psychosis. Copyright © 2014 Society for Psychophysiological Research.

Missing the Party: Political Categorization and Reasoning in the Absence of Party Label Cues.

PubMed

Heit, Evan; Nicholson, Stephen P

2016-07-01

This research addressed theoretical approaches in political science arguing that the American electorate is either poorly informed or dependent on party label cues, by assessing performance on political judgment tasks when party label information is missing. The research materials were created from the results of a national opinion survey held during a national election. The experiments themselves were run on nationally representative samples of adults, identified from another national electoral survey. Participants saw profiles of simulated individuals, including information about demographics and issue positions, but omitting party labels. In Experiment 1, participants successfully judged the likelihood of party membership based on the profiles. In Experiment 2, participants successfully voted based on their party interests. The results were mediated by participants' political knowledge. Conclusions are drawn with respect to theories from political science and issues in cognitive science regarding categorization and reasoning. Copyright © 2016 Cognitive Science Society, Inc.

Technical variables in high-throughput miRNA expression profiling: much work remains to be done.

PubMed

Nelson, Peter T; Wang, Wang-Xia; Wilfred, Bernard R; Tang, Guiliang

2008-11-01

MicroRNA (miRNA) gene expression profiling has provided important insights into plant and animal biology. However, there has not been ample published work about pitfalls associated with technical parameters in miRNA gene expression profiling. One source of pertinent information about technical variables in gene expression profiling is the separate and more well-established literature regarding mRNA expression profiling. However, many aspects of miRNA biochemistry are unique. For example, the cellular processing and compartmentation of miRNAs, the differential stability of specific miRNAs, and aspects of global miRNA expression regulation require specific consideration. Additional possible sources of systematic bias in miRNA expression studies include the differential impact of pre-analytical variables, substrate specificity of nucleic acid processing enzymes used in labeling and amplification, and issues regarding new miRNA discovery and annotation. We conclude that greater focus on technical parameters is required to bolster the validity, reliability, and cultural credibility of miRNA gene expression profiling studies.

Mercury and omega-3 fatty acid profiles in freshwater fish of the Dehcho Region, Northwest Territories: Informing risk benefit assessments.

PubMed

Laird, Matthew J; Henao, Juan J Aristizabal; Reyes, Ellen S; Stark, Ken D; Low, George; Swanson, Heidi K; Laird, Brian D

2018-10-01

Traditional foods have significant nutritional, sociocultural and economic value in subarctic First Nations communities of the Northwest Territories, and play a crucial role in promoting cultural continuity and sovereignty. Omega-3 polyunsaturated fatty acids (N-3 PUFAs), including eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), carry significant benefits for neurocognitive development and cardiovascular health. However, the health risks posed by methylmercury may serve to undermine the benefits of fish consumption in Northern Indigenous communities. The objective of this study was to characterize profiles for mercury (Hg) and fatty acids in fish species harvested across lakes of the Dehcho Region, in the Mackenzie Valley of the Northwest Territories, to better understand the risks and benefits associated with traditional foods. Hg levels increased with trophic position, with the highest levels found in Burbot, Lake Trout, Walleye, and Northern Pike. Lake Trout, along with planktivorous species including Lake Whitefish, Cisco, and Sucker, demonstrated higher N-3 PUFAs than other species. Negative associations were observed between Hg and N-3 PUFAs in Lake Trout, Northern Pike, Walleye and Burbot. Further stratifying these relationships revealed significant interactions by lake. Significant differences observed in fatty acid and Hg profiles across lakes underscore the importance of considering both species- and lake-specific findings. This growing dataset of freshwater fish of the Dehcho will inform future efforts to characterize human Hg exposure profiles using probabilistic dose reconstruction models. Copyright © 2018 Elsevier B.V. All rights reserved.

Growth and BMI during the first 14 y of life in offspring from women with type 1 or type 2 diabetes mellitus.

PubMed

Hammoud, Nurah M; de Valk, Harold W; van Rossem, Lenie; Biesma, Douwe H; Wit, Jan M; Visser, Gerard H A

2017-02-01

Infants of women with pregestational diabetes are at risk for developing obesity in later life. This study aimed to identify subgroups at highest risk, by studying growth profiles of offspring from women with type 1 or 2 diabetes mellitus (ODM1, ODM2) until the age of 14 y. Information from infant welfare centers was received for 78 ODM1 and 44 ODM2. Mean BMI SD scores (SDS) (based on 1980 nation-wide references) and height SDS (based on 2009 references) were calculated and included in a random-effects model. Values were compared to the 2009 Dutch growth study. BMI SDS profiles differed between ODM1 and ODM2, with the highest mean BMI SDS profiles in ODM2. Other factors that affected growth profiles in these infants included the presence of maternal obesity, large for gestational age (LGA) at birth and in ODM2 a Dutch-Mediterranean origin. Offspring of women with diabetes have higher BMI SDS profiles than observed in the 2009 Dutch growth study, with the highest BMI SDS in ODM2 who are LGA at birth and have obese mothers. Preventive strategies for offspring adiposity may include pursuing lower prepregnancy maternal BMI, prevention of LGA at birth, and prevention of increased weight gain during childhood.

Vertical Profiles of Latent Heat Release Over the Global Tropics using TRMM Rainfall Products from December 1997 to November 2001

NASA Technical Reports Server (NTRS)

Tao, W.-K.; Lang, S.; Simpson, J.; Meneghini, R.; Halverson, J.; Johnson, R.; Adler, R.; Starr, David (Technical Monitor)

2002-01-01

NASA Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) derived rainfall information will be used to estimate the four-dimensional structure of global monthly latent heating and rainfall profiles over the global tropics from December 1997 to November 2000. Rainfall, latent heating and radar reflectivity structures between El Nino (DJF 1997-98) and La Nina (DJF 1998-99) will be examined and compared. The seasonal variation of heating over various geographic locations (i.e., oceanic vs continental, Indian ocean vs west Pacific, Africa vs S. America) will also be analyzed. In addition, the relationship between rainfall, latent heating (maximum heating level), radar reflectivity and SST is examined and will be presented in the meeting. The impact of random error and bias in stratiform percentage estimates from PR on latent heating profiles is studied and will also be presented in the meeting. Additional information is included in the original extended abstract.

a Comparitive Study Using Geometric and Vertical Profile Features Derived from Airborne LIDAR for Classifying Tree Genera

NASA Astrophysics Data System (ADS)

Ko, C.; Sohn, G.; Remmel, T. K.

2012-07-01

We present a comparative study between two different approaches for tree genera classification using descriptors derived from tree geometry and those derived from the vertical profile analysis of LiDAR point data. The different methods provide two perspectives for processing LiDAR point clouds for tree genera identification. The geometric perspective analyzes individual tree crowns in relation to valuable information related to characteristics of clusters and line segments derived within crowns and overall tree shapes to highlight the spatial distribution of LiDAR points within the crown. Conversely, analyzing vertical profiles retrieves information about the point distributions with respect to height percentiles; this perspective emphasizes of the importance that point distributions at specific heights express, accommodating for the decreased point density with respect to depth of canopy penetration by LiDAR pulses. The targeted species include white birch, maple, oak, poplar, white pine and jack pine at a study site northeast of Sault Ste. Marie, Ontario, Canada.

A profile of health sciences libraries in Southeast Asia.

PubMed Central

Dhir, S C; Anand, S K

1978-01-01

This paper reports the results of a survey undertaken by the World Health Organization of health sciences libraries in Southeast Asia. It includes information on clientele, budget, personnel, collections, lending policy, dissemination of information, and reference services. The survey indicates that the collections in most of the health sciences libraries in Southeast Asia are deficient and that services provided to readers are inadequate. Recommendations for improvement are outlined. PMID:354704

Simultaneous Retrieval of Temperature, Water Vapor and Ozone Atmospheric Profiles from IASI: Compression, De-noising, First Guess Retrieval and Inversion Algorithms

NASA Technical Reports Server (NTRS)

Aires, F.; Rossow, W. B.; Scott, N. A.; Chedin, A.; Hansen, James E. (Technical Monitor)

2001-01-01

A fast temperature water vapor and ozone atmospheric profile retrieval algorithm is developed for the high spectral resolution Infrared Atmospheric Sounding Interferometer (IASI) space-borne instrument. Compression and de-noising of IASI observations are performed using Principal Component Analysis. This preprocessing methodology also allows, for a fast pattern recognition in a climatological data set to obtain a first guess. Then, a neural network using first guess information is developed to retrieve simultaneously temperature, water vapor and ozone atmospheric profiles. The performance of the resulting fast and accurate inverse model is evaluated with a large diversified data set of radiosondes atmospheres including rare events.

Validation of the alcohol use item banks from the Patient-Reported Outcomes Measurement Information System (PROMIS).

PubMed

Pilkonis, Paul A; Yu, Lan; Dodds, Nathan E; Johnston, Kelly L; Lawrence, Suzanne M; Daley, Dennis C

2016-04-01

The Patient-Reported Outcomes Measurement Information System (PROMIS) includes five item banks for alcohol use. There are limited data, however, regarding their validity (e.g., convergent validity, responsiveness to change). To provide such data, we conducted a prospective study with 225 outpatients being treated for substance abuse. Assessments were completed shortly after intake and at 1-month and 3-month follow-ups. The alcohol item banks were administered as computerized adaptive tests (CATs). Fourteen CATs and one six-item short form were also administered from eight other PROMIS domains to generate a comprehensive health status profile. After modeling treatment outcome for the sample as a whole, correlates of outcome from the PROMIS health status profile were examined. For convergent validity, the largest correlation emerged between the PROMIS alcohol use score and the Alcohol Use Disorders Identification Test (r=.79 at intake). Regarding treatment outcome, there were modest changes across the target problem of alcohol use and other domains of the PROMIS health status profile. However, significant heterogeneity was found in initial severity of drinking and in rates of change for both abstinence and severity of drinking during follow-up. This heterogeneity was associated with demographic (e.g., gender) and health-profile (e.g., emotional support, social participation) variables. The results demonstrated the validity of PROMIS CATs, which require only 4-6 items in each domain. This efficiency makes it feasible to use a comprehensive health status profile within the substance use treatment setting, providing important prognostic information regarding abstinence and severity of drinking. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

12 CFR 225.8 - Capital planning.

Code of Federal Regulations, 2012 CFR

2012-01-01

... this section; (C) A discussion of the results of any stress test required by law or regulation, and an... policies and procedures, including risk management policies and procedures; (v) The bank holding company's liquidity profile and management; and (vi) Any other relevant qualitative or quantitative information...

Girls & Technology: An Idea Book for Educators & Parents.

ERIC Educational Resources Information Center

National Coalition of Girls' Schools, Concord, MA.

This booklet represents an effort to combine research findings, strategies, teaching and parenting tips, activities, career profiles, and print and online information that can help make technology more accessible to girls. Chapters include: "Why a Focus on Girls & Technology: New Priorities"; "Girls & Technology: Different…

Business Portfolio Folder.

ERIC Educational Resources Information Center

Missouri Univ., Columbia. Instructional Materials Lab.

This chart is intended to document a student's mastery of competencies identified as necessary in the Missouri Competency Profile for business education. The chart includes space for recording basic student and instructor information and the student's on-the-job training and work experience. Provided next are rating sheets for various…

Archive of Boomer seismic reflection data: collected during USGS Cruise 96CCT01, nearshore south central South Carolina coast, June 26 - July 1, 1996

USGS Publications Warehouse

Calderon, Karynna; Dadisman, Shawn V.; Kindinger, Jack G.; Flocks, James G.; Wiese, Dana S.

2003-01-01

This archive consists of marine seismic reflection profile data collected in four survey areas from southeast of Charleston Harbor to the mouth of the North Edisto River of South Carolina. These data were acquired June 26 - July 1, 1996, aboard the R/V G.K. Gilbert. Included here are data in a variety of formats including binary, American Standard Code for Information Interchange (ASCII), Hyper Text Markup Language (HTML), Portable Document Format (PDF), Rich Text Format (RTF), Graphics Interchange Format (GIF) and Joint Photographic Experts Group (JPEG) images, and shapefiles. Binary data are in Society of Exploration Geophysicists (SEG) SEG-Y format and may be downloaded for further processing or display. Reference maps and GIF images of the profiles may be viewed with a web browser. The Geographic Information Systems (GIS) map documents provided were created with Environmental Systems Research Institute (ESRI) GIS software ArcView 3.2 and 8.1.

Global metabolic profiling procedures for urine using UPLC-MS.

PubMed

Want, Elizabeth J; Wilson, Ian D; Gika, Helen; Theodoridis, Georgios; Plumb, Robert S; Shockcor, John; Holmes, Elaine; Nicholson, Jeremy K

2010-06-01

The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations in response to physiological challenges, toxic insults or disease processes. Information-rich analytical platforms, such as mass spectrometry (MS), are needed. Here we describe the application of ultra-performance liquid chromatography-MS (UPLC-MS) to urinary metabolite profiling, including sample preparation, stability/storage and the selection of chromatographic conditions that balance metabolome coverage, chromatographic resolution and throughput. We discuss quality control and metabolite identification, as well as provide details of multivariate data analysis approaches for analyzing such MS data. Using this protocol, the analysis of a sample set in 96-well plate format, would take ca. 30 h, including 1 h for system setup, 1-2 h for sample preparation, 24 h for UPLC-MS analysis and 1-2 h for initial data processing. The use of UPLC-MS for metabolic profiling in this way is not faster than the conventional HPLC-based methods but, because of improved chromatographic performance, provides superior metabolome coverage.

A review of online social networking profiles by adolescents: implications for future research and intervention.

PubMed

Williams, Amanda L; Merten, Michael J

2008-01-01

This study explored content posted and interactions taking place on adolescent online social networking profiles. Although "blogging" continues to soar in popularity, with over half of teenagers online participating in some form, little research has comprehensively explored blog communication within the context of adolescent development. Content was qualitatively coded from 100 randomly selected profiles authored by adolescents between the ages of 16 and 18. Rich thematic elements were identified including family and social issues, risk behaviors, disclosure of personally identifiable information, and frequent peer interaction. Results indicate adolescent blogs frequently contain appropriate images, positive comments about parents and peers, athletics, a variety of risk behaviors, and sexual and profane language. In addition, school type was examined (public versus private, religious) as a potential factor in understanding the differences in content posted by adolescents; however, no significant differences were found. Implications for parental monitoring and intervention are discussed as well as direction for future research. Adolescents' online profiles contain a wealth of intimate, candid, and publicly available information on a wide range of social issues pertinent to adolescence that contribute to the understanding of adolescent development and well-being.

Towards an Enhancement of Organizational Information Security through Threat Factor Profiling (TFP) Model

NASA Astrophysics Data System (ADS)

Sidi, Fatimah; Daud, Maslina; Ahmad, Sabariah; Zainuddin, Naqliyah; Anneisa Abdullah, Syafiqa; Jabar, Marzanah A.; Suriani Affendey, Lilly; Ishak, Iskandar; Sharef, Nurfadhlina Mohd; Zolkepli, Maslina; Nur Majdina Nordin, Fatin; Amat Sejani, Hashimah; Ramadzan Hairani, Saiful

2017-09-01

Information security has been identified by organizations as part of internal operations that need to be well implemented and protected. This is because each day the organizations face a high probability of increase of threats to their networks and services that will lead to information security issues. Thus, effective information security management is required in order to protect their information assets. Threat profiling is a method that can be used by an organization to address the security challenges. Threat profiling allows analysts to understand and organize intelligent information related to threat groups. This paper presents a comparative analysis that was conducted to study the existing threat profiling models. It was found that existing threat models were constructed based on specific objectives, thus each model is limited to only certain components or factors such as assets, threat sources, countermeasures, threat agents, threat outcomes and threat actors. It is suggested that threat profiling can be improved by the combination of components found in each existing threat profiling model/framework. The proposed model can be used by an organization in executing a proactive approach to incident management.

A Cabled, High Bandwidth Instrument Platform for Continuous Scanning of the Upper Ocean Water Column

NASA Astrophysics Data System (ADS)

McRae, E.; Delaney, J. R.; Kelly, D.; Daly, K. L.; Luther, D. S.; Harkins, G.; Harrington, M.; McGuire, C.; Tilley, J.; Dosher, J.; Waite, P.; Cram, G.; Kawka, O. E.

2016-02-01

The Cabled Array portion of the National Science Foundation funded Ocean Observatories Initiative is a large scale, high bandwidth and high power subsea science network designed by the University of Washington Applied Physics Laboratory. Part of that system is a set of winched profilers which continuously scan the upper 200m of the ocean at their deployment sites. The custom built profilers leverage the Cabled Array's technology for interfacing collections of science instruments and add the ability to run predefined missions and to switch missions or mission parameters on the fly via command from shore. The profilers were designed to operate continuously for up to two years after deployment after which certain wearing components must be replaced. The data from the profiler's science and engineering sensors are streamed to shore via the seafloor network in real time. Data channel capacity from the profilers exceeds 40 Mbps. For profiler safety, mission execution is controlled within the platform. Inputs such as 3D gyro, pressure depth and deployed cable calculations are monitored to assure safe operation during any sea state. The profilers never surface but are designed to approach within 5m of the surface if conditions allow. Substantial engineering effort was focused on reliable cable handling under all ocean conditions. The profilers are currently operated from subsea moorings which also contain sets of fixed science and engineering sensors. The profilers and their associated mooring instrument assemblies are designed for rapid replacement using ROVs. We have operated this system for two years, including one annual maintenance turn and information relative to that experience will be included in the paper.[Image Caption] Cabled Array Shallow Profiler shown in its parking position.

A Latent Profile Analysis of Latino Parenting: The Infusion of Cultural Values on Family Conflict.

PubMed

Ayón, Cecilia; Williams, Lela Rankin; Marsiglia, Flavio F; Ayers, Stephanie; Kiehne, Elizabeth

The purpose of the present study was to (a) examine how acculturation and social support inform Latinos' parenting behaviors, controlling for gender and education; (b) describe parenting styles among Latino immigrants while accounting for cultural elements; and (c) test how these parenting styles are associated with family conflict. A 3 step latent profile analysis with the sample ( N = 489) revealed best fit with a 4 profile model ( n = 410) of parenting: family parenting ( n = 268, 65%), child-centered parenting ( n = 68, 17%), moderate parenting ( n = 60, 15%), and disciplinarian parenting ( n = 14, 3%). Parents' gender, acculturation, and social support significantly predicted profile membership. Disciplinarian and moderate parenting were associated with more family conflict. Recommendations include integrating culturally based parenting practices as a critical element to family interventions to minimize conflict and promote positive youth development.

User's guide for SBUV/TOMS ozone derivative products

NASA Technical Reports Server (NTRS)

Fleig, A. J.; Wellemeyer, C.; Oslik, N.; Lee, D.; Miller, J.; Magatani, R.

1984-01-01

A series of products are available derived from the total-ozone and ozone vertical profile results for the Solar Backscattered Ultraviolet/Total-Ozone Mapping Spectrometer (SBUV/TOMS) Nimbus-7 operation. Products available are (1) orbital height-latitude cross sections of the SBUV profile data, (2) daily global total ozone contours in polar coordinates, (3) daily averages of total ozone in global 5x5 degree latitude-longitude grid, (4) daily, monthly and quarterly averages of total ozone and profile data in 10 degree latitude zones, (5) tabular presentation of zonal means, (6) daily global total ozone and profile contours in polar coordinates. The ""Derivative Products User's Guide'' describes each of these products in detail, including their derivation and presentation format. Information is provided on how to order the tapes and microfilm from the National Space Science Data Center.

Social network utilization (Facebook) & e-Professionalism among medical students

PubMed Central

Jawaid, Masood; Khan, Muhammad Hassaan; Bhutto, Shahzadi Nisar

2015-01-01

Objective: To find out the frequency and contents of online social networking (Facebook) among medical students of Dow University of Health Sciences. Methods: The sample of the study comprised of final year students of two medical colleges of Dow University of Health Sciences – Karachi. Systematic search for the face book profiles of the students was carried out with a new Facebook account. In the initial phase of search, it was determined whether each student had a Facebook account and the status of account as ‘‘private’’ ‘‘intermediate’’ or ‘‘public’’ was also sought. In the second phase of the study, objective information including gender, education, personal views, likes, tag pictures etc. were recorded for the publicly available accounts. An in depth qualitative content analysis of the public profiles of ten medical students, selected randomly with the help of random number generator technique was conducted. Results: Social networking with Facebook is common among medical students with 66.9% having an account out of a total 535 students. One fifth of profiles 18.9% were publicly open, 36.6% profiles were private and 56.9% were identified to have an intermediate privacy setting, having customized settings for the profile information. In-depth analysis of some public profiles showed that potentially unprofessional material mostly related to violence and politics was posted by medical students. Conclusion: The usage of social network (Facebook) is very common among students of the university. Some unprofessional posts were also found on students’ profiles mostly related to violence and politics. PMID:25878645

Balancing volume and duration of information consumption by physicians: The case of health information exchange in critical care.

PubMed

Politi, Liran; Codish, Shlomi; Sagy, Iftach; Fink, Lior

2017-07-01

The realization of the potential benefits of health information exchange systems (HIEs) for emergency departments (EDs) depends on the way these systems are actually used. The attributes of volume of information and duration of information processing are important for the study of HIE use patterns in the ED, as cognitive load and time constraints may result in a trade-off between these attributes. Experts and non-experts often use different problem-solving strategies, which may be consequential for their system use patterns. Little previous research focuses on the trade-off between volume and duration of system use or on the factors that affect it, including user expertise. This study aims at exploring the trade-off of volume and duration of use, examining whether this relationship differs between experts and non-experts, and identifying factors that are associated with use patterns characterized by volume and duration. The research objectives are pursued in the context of critically-ill patients, treated at a busy ED in the period 2010-2012. The primary source of internal and external data is an HIE linked to 14 hospitals, over 1300 clinics, and other clinical facilities. We define four use profiles based on the attributes of duration and volume: quick and basic, quick and deep, slow and basic, and slow and deep. The volume and duration of use are computed using HIE log files as the number of screens and the time per screen, respectively. Each session is then classified into a specific profile based on distances from predefined profile centroids. Experts are physicians that are board-certified in emergency medicine. We test the distribution of use profiles and their associations with multiple variables that describe the patient, physician, situation, information available in the HIE system, and use dynamics within the encounter. The quick and basic profile is the most prevalent. While available admission summaries are associated with quick and basic use, lab and imaging results are associated with slower or deeper use. Physicians who are the first to use the system or are sole users during an encounter are less inclined to quick and deep use. These effects are intensified for experts. A trade-off between volume and duration is identified. While system use is overall similar for experts and non-experts, the circumstances in which a certain profile is more likely to be observed vary across these two groups. Information availability and multiple-physician dynamics within the encounter emerge as important for the prediction of use profiles. The findings of this study provide implications for the design, implementation, and research of HIE use. Copyright © 2017 Elsevier Inc. All rights reserved.

Hydrokinetic canal measurements: inflow velocity, wake flow velocity, and turbulence

DOE Data Explorer

Gunawan, Budi

2014-06-11

The dataset consist of acoustic Doppler current profiler (ADCP) velocity measurements in the wake of a 3-meter diameter vertical-axis hydrokinetic turbine deployed in Roza Canal, Yakima, WA, USA. A normalized hub-centerline wake velocity profile and two cross-section velocity contours, 10 meters and 20 meters downstream of the turbine, are presented. Mean velocities and turbulence data, measured using acoustic Doppler velocimeter (ADV) at 50 meters upstream of the turbine, are also presented. Canal dimensions and hydraulic properties, and turbine-related information are also included.

STS-1 operational flight profile. Volume 6: Abort analysis

NASA Technical Reports Server (NTRS)

1980-01-01

The abort analysis for the cycle 3 Operational Flight Profile (OFP) for the Space Transportation System 1 Flight (STS-1) is defined, superseding the abort analysis previously presented. Included are the flight description, abort analysis summary, flight design groundrules and constraints, initialization information, general abort description and results, abort solid rocket booster and external tank separation and disposal results, abort monitoring displays and discussion on both ground and onboard trajectory monitoring, abort initialization load summary for the onboard computer, list of the key abort powered flight dispersion analysis.

Wireless autonomous device data transmission

NASA Technical Reports Server (NTRS)

Sammel, Jr., David W. (Inventor); Mickle, Marlin H. (Inventor); Cain, James T. (Inventor); Mi, Minhong (Inventor)

2013-01-01

A method of communicating information from a wireless autonomous device (WAD) to a base station. The WAD has a data element having a predetermined profile having a total number of sequenced possible data element combinations. The method includes receiving at the WAD an RF profile transmitted by the base station that includes a triggering portion having a number of pulses, wherein the number is at least equal to the total number of possible data element combinations. The method further includes keeping a count of received pulses and wirelessly transmitting a piece of data, preferably one bit, to the base station when the count reaches a value equal to the stored data element's particular number in the sequence. Finally, the method includes receiving the piece of data at the base station and using the receipt thereof to determine which of the possible data element combinations the stored data element is.

Teaching EFL outside the United States.

ERIC Educational Resources Information Center

Teachers of English to Speakers of Other Languages.

The guide contains profiles of the linguistic situation and English language teaching conditions, in both public and private sectors, in 48 foreign countries. Descriptions include such information as official language(s), qualifications and requirements for teaching English as a Second Language (ESL), typical class sizes and hours, accessibility…

Microwave Radiometer - UND Radiometrics MWR, Rufus - Reviewed Data

DOE Data Explorer

Leo, Laura

2018-01-09

Reviewed dataset that also includes post-reprocessed level1 and level2 data files from November 2015 to May 2016 (refer to "Additional Information"). Monitor real-time profiles of temperature (K), water vapor (gm-3), relative humidity (%), and liquid water (gm-3) up to 10 km.

Residential and Light Commercial HVAC. Teacher Edition.

ERIC Educational Resources Information Center

Stephenson, David; Fulkerson, Dan, Ed.

This curriculum guide contains 18 units of instruction for a competency-based course in residential and light commercial heating, ventilating, and air conditioning (HVAC). Introductory materials include a competency profile and an instructional/task analysis that correlates job training with related information for this course. Each instructional…

Diesel Technology: Workplace Skills. Teacher Edition and Student Edition.

ERIC Educational Resources Information Center

Kellum, Mary

This publication consists of instructional materials to provide secondary and postsecondary students with skills useful in pursuing a career in the diesel industry. Introductory materials in the teacher edition include information on use of the publication, competency profile, instructional/task analysis, related academic and workplace skills…

SAGE III-ISS

Atmospheric Science Data Center

2017-12-27

SAGE III-ISS Data and Information Launched on February 19, 2017 on a SpaceX ... vertical profiles of the stratosphere and mesosphere. The data provided by SAGE III-ISS includes key components of atmospheric ... Additional Info:  Data Format: HDF4 or Big Endian/IEEE Binary SCAR-B Block:  ...

Tribal Resources Directory of ACF Programs.

ERIC Educational Resources Information Center

Administration for Children and Families (DHHS), Washington, DC.

This directory aims to provide useful information for American Indian tribes and Native American communities about programs funded by the Administration for Children and Families (ACF) that benefit tribal and other Native American service populations. Included are profiles of ACF programs that tribes and eligible Native American organizations may…

Impact of Technology on the Family. Teacher Edition.

ERIC Educational Resources Information Center

Mid-America Vocational Curriculum Consortium, Stillwater, OK.

These instructional materials create an awareness of new technological innovations and how they affect personal and family life. This teacher's guide is for instructing secondary students enrolled in a home economics program. The following introductory information is included: use of this publication, competency profile, instructional/task…

Generic ICT Skills Profiles: Future Skills for Tomorrow's World.

ERIC Educational Resources Information Center

International Co-operation Europe Ltd. (ICEL), Brussels, Belgium.

This document describes generic skills profiles relevant to key jobs in information and communications technology (ICT). The profiles cover the main job areas for which the ICT industry is experiencing skills shortages. These types of information are provided for 18 generic job profiles: job description (vision, role, lifestyle); examples of job…

No programming required. Mobile PCs can help physicians work more efficiently, especially when the application is designed to fit the practice.

PubMed

Campbell, J

2000-09-01

The Jacobson Medical Group San Antonio Jacobson Medical Group (JMG) needed a way to effectively and efficiently coordinate referral information between their hospitalist physicians and specialists. JMG decided to replace paper-based binders with something more convenient and easily updated. The organization chose to implement a mobile solution that would provide its physicians with convenient access to a database of information via a hand-held computer. The hand-held solution provides physicians with full demographic profiles of primary care givers for each area where the group operates. The database includes multiple profiles based on different healthcare plans, along with details about preferred and authorized specialists. JMG adopted a user-friendly solution that the hospitalists and specialists would embrace and actually use.

Needs for providing overseas organ transplant medical function and information with eHealth telecare systems-instrument development for health professionals in Taiwan.

PubMed

Shih, F-J; Fan, Y-W; Chiu, C-M; Shih, F-J; Wang, S-S

2014-05-01

The use of eHealth systems for facilitating overseas organ transplantation (OOT) between 2 medical parties has been discussed. Nevertheless, little information is available about organ transplant health professionals' (OTHPs') needs in using the eHealth telecare systems (eHTSs) for providing OOT medical service. This project attempted to answer this question. A purposive sample including OT surgeons (OTSs), registered nurses (RNs), and organ transplant coordinating nurses (OTCNs) was obtained from 5 hospitals in Taiwan. A Delphi research method was used in this research. The subjects were invited to respond to a sequence of surveys to learn their appraisal of the needs in using eHTSs for providing OOT medical service. Twenty-two subjects including surgeons (n = 10), RNs (n = 9), and OTCNs (n = 3) participated in this research. Their years working in the field ranged from 3 to 45 (mean 15.77) years. To learn OTHPs' appraisals of their needs in using eHTSs for providing OOT medical service, system function requirements (SFR) and system information requirements (SIR) for telecare were produced. SFR were identified to encompass the following 9 aspects: (a) safety in the supervisor mechanism for protection of privacy including account, password, and unediting mode of medical prescriptions; (b) unlimited to particular software or hardware; (c) options of related medical term language in English and traditional and simplified Chinese; (d) available any time and anywhere; (e) being able to save print and export medical records by E-mail systems under authorization; (f) friendly operation; (g) real-time and accurate information; (h) tape-recording functions (OTHPs may convey important medical information to others); and (i) online mutual communications between OTHPs and their clients. SIR included: (a) a comprehensive preoperative medical profile before departure for another country; (b) a comprehensive medical profile of OOT performed in another country; (c) a comprehensive postoperative treatment profile after return to original country; and (d) physiologic health indicators of long-term recovery in the community. In this project, OTHPs addressed their tangible needs for operating an eHTS to facilitate OOT. These findings would serve as a valuable reference for eHTS experts to continue to work with OTHPs to move to the next development stage. Copyright © 2014 Elsevier Inc. All rights reserved.

Effect of oxidizing adulterants on human urinary steroid profiles.

PubMed

Kuzhiumparambil, Unnikrishnan; Fu, Shanlin

2013-02-01

Steroid profiling is the most versatile and informative technique adapted by doping control laboratories for detection of steroid abuse. The absolute concentrations and ratios of endogenous steroids including testosterone, epitestosterone, androsterone, etiocholanolone, 5α-androstane-3α,17β-diol and 5β-androstane-3α,17β-diol constitute the significant characteristics of a steroid profile. In the present study we report the influence of various oxidizing adulterants on the steroid profile of human urine. Gas chromatography-mass spectrometry analysis was carried out to develop the steroid profile of human male and female urine. Oxidants potassium nitrite, sodium hypochlorite, potassium permanganate, cerium ammonium nitrate, sodium metaperiodate, pyridinium chlorochromate, potassium dichromate and potassium perchlorate were reacted with urine at various concentrations and conditions and the effect of these oxidants on the steroid profile were analyzed. Most of the oxidizing chemicals led to significant changes in endogenous steroid profile parameters which were considered stable under normal conditions. These oxidizing chemicals can cause serious problems regarding the interpretation of steroid profiles and have the potential to act as masking agents that can complicate or prevent the detection of the steroid abuse. Copyright © 2012 Elsevier Inc. All rights reserved.

A new retrieval algorithm for tropospheric temperature, humidity and pressure profiling based on GNSS radio occultation data

NASA Astrophysics Data System (ADS)

Kirchengast, Gottfried; Li, Ying; Scherllin-Pirscher, Barbara; Schwärz, Marc; Schwarz, Jakob; Nielsen, Johannes K.

2017-04-01

The GNSS radio occultation (RO) technique is an important remote sensing technique for obtaining thermodynamic profiles of temperature, humidity, and pressure in the Earth's troposphere. However, due to refraction effects of both dry ambient air and water vapor in the troposphere, retrieval of accurate thermodynamic profiles at these lower altitudes is challenging and requires suitable background information in addition to the RO refractivity information. Here we introduce a new moist air retrieval algorithm aiming to improve the quality and robustness of retrieving temperature, humidity and pressure profiles in moist air tropospheric conditions. The new algorithm consists of four steps: (1) use of prescribed specific humidity and its uncertainty to retrieve temperature and its associated uncertainty; (2) use of prescribed temperature and its uncertainty to retrieve specific humidity and its associated uncertainty; (3) use of the previous results to estimate final temperature and specific humidity profiles through optimal estimation; (4) determination of air pressure and density profiles from the results obtained before. The new algorithm does not require elaborated matrix inversions which are otherwise widely used in 1D-Var retrieval algorithms, and it allows a transparent uncertainty propagation, whereby the uncertainties of prescribed variables are dynamically estimated accounting for their spatial and temporal variations. Estimated random uncertainties are calculated by constructing error covariance matrices from co-located ECMWF short-range forecast and corresponding analysis profiles. Systematic uncertainties are estimated by empirical modeling. The influence of regarding or disregarding vertical error correlations is quantified. The new scheme is implemented with static input uncertainty profiles in WEGC's current OPSv5.6 processing system and with full scope in WEGC's next-generation system, the Reference Occultation Processing System (rOPS). Results from both WEGC systems, current OPSv5.6 and next-generation rOPS, are shown and discussed, based on both insights from individual profiles and statistical ensembles, and compared to moist air retrieval results from the UCAR Boulder and ROM-SAF Copenhagen centers. The results show that the new algorithmic scheme improves the temperature, humidity and pressure retrieval performance, in particular also the robustness including for integrated uncertainty estimation for large-scale applications, over the previous algorithms. The new rOPS-implemented algorithm will therefore be used in the first large-scale reprocessing towards a tropospheric climate data record 2001-2016 by the rOPS, including its integrated uncertainty propagation.

Public Health Literature Review of Fragile X Syndrome

PubMed Central

Raspa, Melissa; Wheeler, Anne C.; Riley, Catharine

2017-01-01

OBJECTIVES The purpose of this systematic literature review is to describe what is known about fragile X syndrome (FXS) and to identify research gaps. The results can be used to help inform future public health research and provide pediatricians with up-to-date information about the implications of the condition for individuals and their families. METHODS An electronic literature search was conducted, guided by a variety of key words. The search focused on 4 areas of both clinical and public health importance: (1) the full mutation phenotype, (2) developmental trajectories across the life span, (3) available interventions and treatments, and (4) impact on the family. A total of 661 articles were examined and 203 were included in the review. RESULTS The information is presented in the following categories: developmental profile (cognition, language, functional skills, and transition to adulthood), social-emotional profile (cooccurring psychiatric conditions and behavior problems), medical profile (physical features, seizures, sleep, health problems, and physiologic features), treatment and interventions (educational/behavioral, allied health services, and pharmacologic), and impact on the family (family environment and financial impact). Research gaps also are presented. CONCLUSIONS The identification and treatment of FXS remains an important public health and clinical concern. The information presented in this article provides a more robust understanding of FXS and the impact of this complex condition for pediatricians. Despite a wealth of information about the condition, much work remains to fully support affected individuals and their families. PMID:28814537

Public Health Literature Review of Fragile X Syndrome.

PubMed

Raspa, Melissa; Wheeler, Anne C; Riley, Catharine

2017-06-01

The purpose of this systematic literature review is to describe what is known about fragile X syndrome (FXS) and to identify research gaps. The results can be used to help inform future public health research and provide pediatricians with up-to-date information about the implications of the condition for individuals and their families. An electronic literature search was conducted, guided by a variety of key words. The search focused on 4 areas of both clinical and public health importance: (1) the full mutation phenotype, (2) developmental trajectories across the life span, (3) available interventions and treatments, and (4) impact on the family. A total of 661 articles were examined and 203 were included in the review. The information is presented in the following categories: developmental profile (cognition, language, functional skills, and transition to adulthood), social-emotional profile (cooccurring psychiatric conditions and behavior problems), medical profile (physical features, seizures, sleep, health problems, and physiologic features), treatment and interventions (educational/behavioral, allied health services, and pharmacologic), and impact on the family (family environment and financial impact). Research gaps also are presented. The identification and treatment of FXS remains an important public health and clinical concern. The information presented in this article provides a more robust understanding of FXS and the impact of this complex condition for pediatricians. Despite a wealth of information about the condition, much work remains to fully support affected individuals and their families. Copyright © 2017 by the American Academy of Pediatrics.

2D first break tomographic processing of data measured for celebration profiles: CEL01, CEL04, CEL05, CEL06, CEL09, CEL11

NASA Astrophysics Data System (ADS)

Bielik, M.; Vozar, J.; Hegedus, E.; Celebration Working Group

2003-04-01

The contribution informs about the preliminary results that relate to the first arrival p-wave seismic tomographic processing of data measured along the profiles CEL01, CEL04, CEL05, CEL06, CEL09 and CEL11. These profiles were measured in a framework of the seismic project called CELEBRATION 2000. Data acquisition and geometric parameters of the processed profiles, tomographic processing’s principle, particular processing steps and program parameters are described. Characteristic data (shot points, geophone points, total length of profiles, for all profiles, sampling, sensors and record lengths) of observation profiles are given. The fast program package developed by C. Zelt was applied for tomographic velocity inversion. This process consists of several steps. First step is a creation of the starting velocity field for which the calculated arrival times are modelled by the method of finite differences. The next step is minimization of differences between the measured and modelled arrival time till the deviation is small. Elimination of equivalency problem by including a priori information in the starting velocity field was done too. A priori information consists of the depth to the pre-Tertiary basement, estimation of its overlying sedimentary velocity from well-logging and or other seismic velocity data, etc. After checking the reciprocal times, pickings were corrected. The final result of the processing is a reliable travel time curve set considering the reciprocal times. We carried out picking of travel time curves, enhancement of signal-to-noise ratio on the seismograms using the program system of PROMAX. Tomographic inversion was carried out by so called 3D/2D procedure taking into account 3D wave propagation. It means that a corridor along the profile, which contains the outlying shot points and geophone points as well was defined and we carried out 3D processing within this corridor. The preliminary results indicate the seismic anomalous zones within the crust and the uppermost part of the upper mantle in the area consists of the Western Carpathians, the North European platform, the Pannonian basin and the Bohemian Massif.

Gut microbiota composition modifies fecal metabolic profiles in mice.

PubMed

Zhao, Ying; Wu, Junfang; Li, Jia V; Zhou, Ning-Yi; Tang, Huiru; Wang, Yulan

2013-06-07

The gut microbiome is known to be extensively involved in human health and disease. In order to reveal the metabolic relationship between host and microbiome, we monitored recovery of the gut microbiota composition and fecal profiles of mice after gentamicin and/or ceftriaxone treatments. This was performed by employing (1)H nuclear magnetic resonance (NMR)-based metabonomics and denaturing gradient gel electrophoresis (DGGE) fingerprint of gut microbiota. The common features of fecal metabolites postantibiotic treatment include decreased levels of short chain fatty acids (SCFAs), amino acids and primary bile acids and increased oligosaccharides, d-pinitol, choline and secondary bile acids (deoxycholic acid). This suggests suppressed bacterial fermentation, protein degradation and enhanced gut microbial modification of bile acids. Barnesiella, Prevotella, and Alistipes levels were shown to decrease as a result of the antibiotic treatment, whereas levels of Bacteroides, Enterococcus and Erysipelotrichaceae incertae sedis, and Mycoplasma increased after gentamicin and ceftriaxone treatment. In addition, there was a strong correlation between fecal profiles and levels of Bacteroides, Barnesiella, Alistipes and Prevotella. The integration of metabonomics and gut microbiota profiling provides important information on the changes of gut microbiota and their impact on fecal profiles during the recovery after antibiotic treatment. The correlation between gut microbiota and fecal metabolites provides important information on the function of bacteria, which in turn could be important in optimizing therapeutic strategies, and developing potential microbiota-based disease preventions and therapeutic interventions.

Total Solar Eclipse of 2006 March 29

NASA Technical Reports Server (NTRS)

Espenak, F.; Anderson, J.

2004-01-01

On 2006 March 29, a total eclipse of the Sun will be visible from within a narrow corridor which traverses half the Earth. The path of the Moon's umbral shadow begins in Brazil and extends across the Atlantic, northern Africa, and central Asia where it ends at sunset in western Mongolia. A partial eclipse will be seen within the much broader path of the Moon's penumbral shadow, which includes the northern two thirds of Africa, Europe, and central Asia.Detailed predictions for this event are presented and include besselian elements, geographic coordinates of the path of totality, physical ephemeris of the umbra, topocentric limb profile corrections, local circumstances for approximately 350 cities, maps of the eclipse path, weather prospects, the lunar limb profile, and the sky during totality. Information on safe eclipse viewing and eclipse photography is included.

Total Solar Eclipse of 2002 December 04

NASA Technical Reports Server (NTRS)

Espenak, Fred; Anderson, Jay

2001-01-01

On 2002 December 04, a total eclipse of the Sun will be visible from within a narrow corridor which traverses the Southern Hemisphere. The path of the Moon's umbral shadow begins in the South Atlantic, crosses southern Africa and the Indian Ocean, and ends at sunset in southern Australia. A partial eclipse will be seen within the much broader path of the Moon's penumbral shadow, which includes the southern two thirds of Africa, Antarctica, Indian Ocean and Australia. Detailed predictions for this event are presented and include besselian elements, geographic coordinates of the path of totality, physical ephemeris of the umbra, topocentric limb profile corrections, local circumstances for approximately 400 cities, maps of the eclipse path, weather prospects, the lunar limb profile and the sky during totality. Information on safe eclipse viewing and eclipse photography is included.

Leaking privacy and shadow profiles in online social networks.

PubMed

Garcia, David

2017-08-01

Social interaction and data integration in the digital society can affect the control that individuals have on their privacy. Social networking sites can access data from other services, including user contact lists where nonusers are listed too. Although most research on online privacy has focused on inference of personal information of users, this data integration poses the question of whether it is possible to predict personal information of nonusers. This article tests the shadow profile hypothesis, which postulates that the data given by the users of an online service predict personal information of nonusers. Using data from a disappeared social networking site, we perform a historical audit to evaluate whether personal data of nonusers could have been predicted with the personal data and contact lists shared by the users of the site. We analyze personal information of sexual orientation and relationship status, which follow regular mixing patterns in the social network. Going back in time over the growth of the network, we measure predictor performance as a function of network size and tendency of users to disclose their contact lists. This article presents robust evidence supporting the shadow profile hypothesis and reveals a multiplicative effect of network size and disclosure tendencies that accelerates the performance of predictors. These results call for new privacy paradigms that take into account the fact that individual privacy decisions do not happen in isolation and are mediated by the decisions of others.

The Detroit River, Michigan: an ecological profile

USGS Publications Warehouse

Manny, Bruce A.; Edsall, Thomas A.; Jaworski, Eugene

1988-01-01

A part of the connecting channel system between Lake Huron and Lake Erie, the Detroit River forms an integral link between the two lakes for both humans and biological resources such as fish, nutrients, and plant detritus. This profile summarizes existing scientific information on the ecological structure and functioning of this ecosystem. Topics include the geological history of the region, climatic influences, river hydrology, lower trophic-level biotic components, native and introduced fishes, waterfowl use, ecological interrelationships, commercial and recreational uses of the river, and current management issues. Despite urbanization, the river still supports diverse fish, waterfowl, and benthic populations. Management issues include sewer overflows; maintenance dredging for navigation and port activities; industrial discharges of potentially hazardous materials; and wetland, fishery, and waterfowl protection and enhancement.

Keeping in the Mainstream: Houston Public Library.

ERIC Educational Resources Information Center

Mashinic, Ann

1984-01-01

Profile of the Houston Public Library, which was established in 1904, covers the opening of a new central library building in 1976, library services and collections, the building of branch libraries including a portable mall facility, information and referral programs to ethnic groups and business, and development of library automated systems.…

State Network Utilization Study: Mississippi Educational Television.

ERIC Educational Resources Information Center

Wilson, Savan; And Others

This document is the result of a utilization study of Mississippi Educational Television where 27 target audiences were identified and surveyed. The following information is included: a draft of and updated state network utilization studies; planning and management strategies; a profile of the survey populations; a distance learning survey report;…

The Moton Guide to American Colleges with a Black Heritage, 1974-75.

ERIC Educational Resources Information Center

Moton Consortium on Admissions and Financial Aid, Washington, DC.

This directory provides information on specific colleges and universities with a black heritage, including the academic and monetary requirements, financial aid, student activities, military programs, academic programs, a brief faculty profile, and campus characteristics. Institutions are listed in alphabetical order with cross reference tables…

Ghana. Country Demographic Profiles, No. 5.

ERIC Educational Resources Information Center

Bureau of the Census (DOC), Suitland, MD. Population Div.

Tables of demographic information about Ghana are presented, including size of population and estimates of fertility and mortality. The data were obtained primarily from population censuses in 1960 and 1970, a 1960 post-enumeration survey, and a 1971 supplementary enquiry. Because Ghana's vital registration system is incomplete, the data are not…

Using Cable Television for Library Data Transmission.

ERIC Educational Resources Information Center

Whitaker, Douglas A.

1985-01-01

Discusses information gained from a test of cable data circuits on a Geac bibliographic control system at the Wayne Oakland Library Federation (WOLF) (Michigan). Highlights include an introduction to cable, hardware profile, the WOLF experience, and key questions that will affect the future use of cable for data transmission. (EJS)

Food Production, Management, and Services. Baking. Teacher Edition. Second Edition.

ERIC Educational Resources Information Center

Gibson, LeRoy

These instructional materials are intended for a course on food production, management, and services involved in baking. The following introductory information is included: use of this publication; competency profile; instructional/task analysis; related academic and workplace skills list; tools, materials, and equipment list; 13 references; and a…

Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA’s ToxRefDB

EPA Science Inventory

As the primary source for regulatory developmental toxicity information, prenatal studies characterize maternal effects and fetal endpoints including malformations, resorptions, and fetal weight reduction. Results from 383 rat and 368 rabbit prenatal studies on 387 chemicals, mo...

30 CFR 282.5 - Disclosure of data and information to the public.

Code of Federal Regulations, 2014 CFR

2014-07-01

... public. 282.5 Section 282.5 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT... (including, but not limited to, bathymetry, side-scan sonar, subbottom profiler, and magnetometer) in compliance with stipulations or orders concerning protection of environmental aspects of the lease may be...

30 CFR 282.5 - Disclosure of data and information to the public.

Code of Federal Regulations, 2012 CFR

2012-07-01

... public. 282.5 Section 282.5 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT... (including, but not limited to, bathymetry, side-scan sonar, subbottom profiler, and magnetometer) in compliance with stipulations or orders concerning protection of environmental aspects of the lease may be...

30 CFR 282.5 - Disclosure of data and information to the public.

Code of Federal Regulations, 2013 CFR

2013-07-01

... public. 282.5 Section 282.5 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT... (including, but not limited to, bathymetry, side-scan sonar, subbottom profiler, and magnetometer) in compliance with stipulations or orders concerning protection of environmental aspects of the lease may be...

Ground-Based Remote or In Situ Measurement of Vertical Profiles of Wind in the Lower Troposphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clifton, Andrew; Newman, Jennifer

Knowledge of winds in the lower troposphere is essential for a range of applications, including weather forecasting, transportation, natural hazards, and wind energy. This presentation focuses on the measurement of vertical profiles of wind in the lower troposphere for wind energy applications. This presentation introduces the information that wind energy site development and operations require, how it used, and the benefits and problems of current measurements from in-situ measurements and remote sensing. The development of commercial Doppler wind lidar systems over the last 10 years are shown, along with the lessons learned from this experience. Finally, potential developments in windmore » profiling aimed at reducing uncertainty and increasing data availability are introduced.« less

2018 DOE Solid-State Lighting Project Portfolio

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2018 Solid-State Lighting Project Portfolio provides an overview of all SSL projects that have been funded by DOE since 2000. Projects that were active during 2017 are found in the main body of this report, and all historic projects can be found in the appendix. Within these sections, project profiles are sorted by technology type (i.e., LED or OLED) and then by performer name. A profile is provided on each project. Each profile includes a brief technical description, as well as information about project partners, funding, and the research period. This report is updated annually, although the research describedmore » in the Portfolio changes periodically as new projects are initiated and existing ones are concluded.« less

Low-flow profiles of the upper Savannah and Ogeechee Rivers and tributaries in Georgia

USGS Publications Warehouse

Carter, R.F.; Hopkins, E.H.; Perlman, H.A.

1988-01-01

Low flow information is provided for use in an evaluation of the capacity of streams to permit withdrawals or to accept waste loads without exceeding the limits of State water quality standards. The purpose of this report is to present the results of a compilation of available low flow data in the form of tables and ' 7Q10 flow profiles ' (minimum average flow for 7 consecutive days with a 10-yr recurrence interval)(7Q10 flow plotted against distance along a stream channel) for all streams reaches of the Upper Savannah and Ogeechee Rivers and tributaries where sufficient data of acceptable accuracy are available. Drainage area profiles are included for all stream basins larger than 5 sq mi, except for those in a few remote areas. This report is the third in a series of reports that will cover all stream basins north of the Fall Line in Georgia. It includes the Georgia part of the Savannah River basin from its headwaters down to and including McBean Creek, and Brier Creek from its headwaters down to and including Boggy Gut Creek. It also includes the Ogeechee River from its headwaters down to and including Big Creek, and Rocky Comfort Creek (tributary to Ogeechee River) down to the Glascock-Jefferson County line. Flow records were not adjusted for diversions or other factors that cause measured flows to represent other than natural flow conditions. The 7-day minimum flow profile was omitted for stream reaches where natural flow was known to be altered significantly. (Lantz-PTT)

Attitude profile design program

NASA Technical Reports Server (NTRS)

1991-01-01

The Attitude Profile Design (APD) Program was designed to be used as a stand-alone addition to the Simplex Computation of Optimum Orbital Trajectories (SCOOT). The program uses information from a SCOOT output file and the user defined attitude profile to produce time histories of attitude, angular body rates, and accelerations. The APD program is written in standard FORTRAN77 and should be portable to any machine that has an appropriate compiler. The input and output are through formatted files. The program reads the basic flight data, such as the states of the vehicles, acceleration profiles, and burn information, from the SCOOT output file. The user inputs information about the desired attitude profile during coasts in a high level manner. The program then takes these high level commands and executes the maneuvers, outputting the desired information.

Adaptive User Profiles in Pervasive Advertising Environments

NASA Astrophysics Data System (ADS)

Alt, Florian; Balz, Moritz; Kristes, Stefanie; Shirazi, Alireza Sahami; Mennenöh, Julian; Schmidt, Albrecht; Schröder, Hendrik; Goedicke, Michael

Nowadays modern advertising environments try to provide more efficient ads by targeting costumers based on their interests. Various approaches exist today as to how information about the users' interests can be gathered. Users can deliberately and explicitly provide this information or user's shopping behaviors can be analyzed implicitly. We implemented an advertising platform to simulate an advertising environment and present adaptive profiles, which let users setup profiles based on a self-assessment, and enhance those profiles with information about their real shopping behavior as well as about their activity intensity. Additionally, we explain how pervasive technologies such as Bluetooth can be used to create a profile anonymously and unobtrusively.

Entropic Profiler – detection of conservation in genomes using information theory

PubMed Central

Fernandes, Francisco; Freitas, Ana T; Almeida, Jonas S; Vinga, Susana

2009-01-01

Background In the last decades, with the successive availability of whole genome sequences, many research efforts have been made to mathematically model DNA. Entropic Profiles (EP) were proposed recently as a new measure of continuous entropy of genome sequences. EP represent local information plots related to DNA randomness and are based on information theory and statistical concepts. They express the weighed relative abundance of motifs for each position in genomes. Their study is very relevant because under or over-representation segments are often associated with significant biological meaning. Findings The Entropic Profiler application here presented is a new tool designed to detect and extract under and over-represented DNA segments in genomes by using EP. It allows its computation in a very efficient way by recurring to improved algorithms and data structures, which include modified suffix trees. Available through a web interface and as downloadable source code, it allows to study positions and to search for motifs inside the whole sequence or within a specified range. DNA sequences can be entered from different sources, including FASTA files, pre-loaded examples or resuming a previously saved work. Besides the EP value plots, p-values and z-scores for each motif are also computed, along with the Chaos Game Representation of the sequence. Conclusion EP are directly related with the statistical significance of motifs and can be considered as a new method to extract and classify significant regions in genomes and estimate local scales in DNA. The present implementation establishes an efficient and useful tool for whole genome analysis. PMID:19416538

Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss.

PubMed

Santos, Heitor O; Macedo, Rodrigo C O

2018-04-01

Intermittent fasting, whose proposed benefits include the improvement of lipid profile and the body weight loss, has gained considerable scientific and popular repercussion. This review aimed to consolidate studies that analyzed the lipid profile in humans before and after intermittent fasting period through a detailed review; and to propose the physiological mechanism, considering the diet and the body weight loss. Normocaloric and hypocaloric intermittent fasting may be a dietary method to aid in the improvement of the lipid profile in healthy, obese and dyslipidemic men and women by reducing total cholesterol, LDL, triglycerides and increasing HDL levels. However, the majority of studies that analyze the intermittent fasting impacts on the lipid profile and body weight loss are observational based on Ramadan fasting, which lacks large sample and detailed information about diet. Randomized clinical trials with a larger sample size are needed to evaluate the IF effects mainly in patients with dyslipidemia. Copyright © 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

[Professional profiles of graduates from Chilean faculties of medicine].

PubMed

Parada, Mario; Romero, María I; Moraga, Fabián

2015-04-01

The professional profile of health care professionals should incorporate recommendations of international agencies and adapt to the local conditions of each country. To conduct a qualitative analysis of Medical Graduate Profiles of universities grouped in the Chilean Association of Medicine Faculties (ASOFAMECH), characterizing its Social Focus, Humanist Approach, Social and Communication Skills. Documentary analysis of profiles published on the respective web pages, using Atlas Ti software, establishing emerging categories and subcategories. These profiles were compared with the recommendations of the Pan-American Health Organization. Data in Social Focus suggests that although community issues are a common element, the work in primary health and health promotion are rarely included. The Humanist Approach is addressed more commonly than the Social Focus, emphasizing humanization of care, ethical and religious values. Although, social and communication skills are scarcely acknowledged, those mentioned are teamwork and leadership role. There is a marked heterogeneity in the information declared and universities have not fully incorporated the recommendations of international organizations.

Automated cell-type classification in intact tissues by single-cell molecular profiling

PubMed Central

2018-01-01

A major challenge in biology is identifying distinct cell classes and mapping their interactions in vivo. Tissue-dissociative technologies enable deep single cell molecular profiling but do not provide spatial information. We developed a proximity ligation in situ hybridization technology (PLISH) with exceptional signal strength, specificity, and sensitivity in tissue. Multiplexed data sets can be acquired using barcoded probes and rapid label-image-erase cycles, with automated calculation of single cell profiles, enabling clustering and anatomical re-mapping of cells. We apply PLISH to expression profile ~2900 cells in intact mouse lung, which identifies and localizes known cell types, including rare ones. Unsupervised classification of the cells indicates differential expression of ‘housekeeping’ genes between cell types, and re-mapping of two sub-classes of Club cells highlights their segregated spatial domains in terminal airways. By enabling single cell profiling of various RNA species in situ, PLISH can impact many areas of basic and medical research. PMID:29319504

Qualitative Twitter analysis of participants, tweet strategies, and tweet content at a major urologic conference.

PubMed

Borgmann, Hendrik; Woelm, Jan-Henning; Merseburger, Axel; Nestler, Tim; Salem, Johannes; Brandt, Maximilian P; Haferkamp, Axel; Loeb, Stacy

2016-01-01

The microblogging social media platform Twitter is increasingly being adopted in the urologic field. We aimed to analyze participants, tweet strategies, and tweet content of the Twitter discussion at a urologic conference. A comprehensive analysis of the Twitter activity at the European Association of Urology Congress 2013 (#eau2013) was performed, including characteristics of user profiles, engagement and popularity measurements, characteristics and timing of tweets, and content analysis. Of 218 Twitter contributors, doctors (45%) were the most frequent, ahead of associations (15%), companies (10%), and journals (3%). However, journals had the highest tweet/participant rate (22 tweets/participant), profile activity (median: 1177, total tweets, 1805 followers, 979 following), and profile popularity (follower/following ratio: 2.1; retweet rank percentile: 96%). Links in a profile were associated with higher engagement (p<0.0001) and popularity (p<0.0001). Of 1572 tweets, 57% were original tweets, 71% contained mentions, 20% contained links, and 25% included pictures. The majority of tweets (88%) were during conference hours, with an average of 24.7 tweets/hour and a peak activity of 71 tweets/hour. Overall, 59% of tweets were informative, led by the topics uro-oncology (21%), urologic research (21%), and urotechnology (12%). Limitations include the analysis of a single conference analysis, assessment of global profile and not domain-specific activity, and the rapid evolution in Twitter-using habits. Results of this single conference qualitative analysis are promising for an enrichment of the scientific discussions at urologic conferences through the use of Twitter.

Sponge divers of the Aegean and medical consequences of risky compressed-air dive profiles.

PubMed

Toklu, Akin Savas; Cimsit, Maide

2009-04-01

Historically, Turkey once had a substantial number of professional sponge divers, a population known for a relatively high incidence of diving-related conditions such as decompression sickness (DCS) and dysbaric osteonecrosis (DON). Sponge diving ended in the mid-1980s when nearly all of the sponges in the Aegean and Mediterranean Seas contracted a bacterial disease and the occupation became unprofitable. We reviewed the records of Turkish sponge divers for information on their level of knowledge, diving equipment, dive profiles, and occupational health problems. Information was collected by: 1) interviewing former sponge divers near Bodrum, where most of them had settled; 2) reviewing the relevant literature; and 3) examining the medical records of sponge divers who underwent recompression treatment. These divers used three types of surface-supplied equipment, including hard helmets, Fernez apparatus, and hookahs; the latter were preferred because they allowed divers the greatest freedom of movement while harvesting sponges underwater. These divers used profiles that we now know involved a high risk for DCS and DON. We were able to access the records of 58 divers who had received recompression treatment. All of the cases involved severe DCS and delays from dive to recompression that averaged 72 h. Complete resolution of symptoms occurred in only 11 cases (19%). Thus, we were able to document the several factors that contributed to the risks in this occupational group, including unsafe dive profiles, resistance to seeking treatment, long delays before recompression, and the fact that recompression treatment used air rather than oxygen.

Non-muscle invasive bladder cancer: Are epicrises the ‘Bermuda Triangle’ of information transfer?

PubMed Central

May, Matthias; Wick, Anne-Kathrin; Roiner, Michael; Mathew, Marcella; Gilfrich, Christian; Schostak, Martin

2017-01-01

Introduction The aim of the study was to collect information regarding the quality of communication of risk-determining factors or risk profile, and the guideline conformity of recommendations for adjuvant treatment in patients with non-muscle invasive bladder cancer (NMIBC) between clinical and ambulatory urologists. Material and methods At three German urological clinics during the period between 2012-2014, epicrises of 1,033 NMIBC-patients were retrospectively summarised to 505 tumour episodes (tumour resection including any re-resections) and analysed regarding the endpoints 1) risk profile is explicitly named or recorded risk factors are sufficient for the determination of risk profile, and 2) guideline conformity of treatment recommendation. Independent factors influencing the endpoints were determined by means of multivariate logistic regression models. Results The risk profile was explicitly named for 3.6% of tumour episodes; for 68.9% a risk profile could be derived from the information in the epicrises. Treatment recommendations were given for 93.7% of tumour episodes, but only 17.8% were guideline compliant. 42.6% of the recommendations were not reliably effective; 33.1% and 0.2% resulted in under- and overtreatment respectively. Neither endpoint showed gender specific or regional differences, but both were considerably less likely to be achieved in case of recurrence. Conclusions The discrepancy between treatment recommendation (93.7%) and guideline compliance (17.8%) could indicate a lack of familiarity with guidelines. The quality of the epicrises of NMIBC-patients was poor and bore the potential risk of undertreatment. The results of this study are not necessarily applicable to other clinics, but could, however, prompt physicians to re-examine epicrises for the fulfillment of the quality criteria examined here. PMID:29104786

Non-muscle invasive bladder cancer: Are epicrises the 'Bermuda Triangle' of information transfer?

PubMed

Lebentrau, Steffen; May, Matthias; Wick, Anne-Kathrin; Roiner, Michael; Mathew, Marcella; Gilfrich, Christian; Schostak, Martin

2017-01-01

The aim of the study was to collect information regarding the quality of communication of risk-determining factors or risk profile, and the guideline conformity of recommendations for adjuvant treatment in patients with non-muscle invasive bladder cancer (NMIBC) between clinical and ambulatory urologists. At three German urological clinics during the period between 2012-2014, epicrises of 1,033 NMIBC-patients were retrospectively summarised to 505 tumour episodes (tumour resection including any re-resections) and analysed regarding the endpoints 1) risk profile is explicitly named or recorded risk factors are sufficient for the determination of risk profile, and 2) guideline conformity of treatment recommendation. Independent factors influencing the endpoints were determined by means of multivariate logistic regression models. The risk profile was explicitly named for 3.6% of tumour episodes; for 68.9% a risk profile could be derived from the information in the epicrises. Treatment recommendations were given for 93.7% of tumour episodes, but only 17.8% were guideline compliant. 42.6% of the recommendations were not reliably effective; 33.1% and 0.2% resulted in under- and overtreatment respectively. Neither endpoint showed gender specific or regional differences, but both were considerably less likely to be achieved in case of recurrence. The discrepancy between treatment recommendation (93.7%) and guideline compliance (17.8%) could indicate a lack of familiarity with guidelines. The quality of the epicrises of NMIBC-patients was poor and bore the potential risk of undertreatment. The results of this study are not necessarily applicable to other clinics, but could, however, prompt physicians to re-examine epicrises for the fulfillment of the quality criteria examined here.

The role of ECoG magnitude and phase in decoding position, velocity, and acceleration during continuous motor behavior

PubMed Central

Hammer, Jiri; Fischer, Jörg; Ruescher, Johanna; Schulze-Bonhage, Andreas; Aertsen, Ad; Ball, Tonio

2013-01-01

In neuronal population signals, including the electroencephalogram (EEG) and electrocorticogram (ECoG), the low-frequency component (LFC) is particularly informative about motor behavior and can be used for decoding movement parameters for brain-machine interface (BMI) applications. An idea previously expressed, but as of yet not quantitatively tested, is that it is the LFC phase that is the main source of decodable information. To test this issue, we analyzed human ECoG recorded during a game-like, one-dimensional, continuous motor task with a novel decoding method suitable for unfolding magnitude and phase explicitly into a complex-valued, time-frequency signal representation, enabling quantification of the decodable information within the temporal, spatial and frequency domains and allowing disambiguation of the phase contribution from that of the spectral magnitude. The decoding accuracy based only on phase information was substantially (at least 2 fold) and significantly higher than that based only on magnitudes for position, velocity and acceleration. The frequency profile of movement-related information in the ECoG data matched well with the frequency profile expected when assuming a close time-domain correlate of movement velocity in the ECoG, e.g., a (noisy) “copy” of hand velocity. No such match was observed with the frequency profiles expected when assuming a copy of either hand position or acceleration. There was also no indication of additional magnitude-based mechanisms encoding movement information in the LFC range. Thus, our study contributes to elucidating the nature of the informative LFC of motor cortical population activity and may hence contribute to improve decoding strategies and BMI performance. PMID:24198757

PDEPTH—A computer program for the geophysical interpretation of magnetic and gravity profiles through Fourier filtering, source-depth analysis, and forward modeling

USGS Publications Warehouse

Phillips, Jeffrey D.

2018-01-10

PDEPTH is an interactive, graphical computer program used to construct interpreted geological source models for observed potential-field geophysical profile data. The current version of PDEPTH has been adapted to the Windows platform from an earlier DOS-based version. The input total-field magnetic anomaly and vertical gravity anomaly profiles can be filtered to produce derivative products such as reduced-to-pole magnetic profiles, pseudogravity profiles, pseudomagnetic profiles, and upward-or-downward-continued profiles. A variety of source-location methods can be applied to the original and filtered profiles to estimate (and display on a cross section) the locations and physical properties of contacts, sheet edges, horizontal line sources, point sources, and interface surfaces. Two-and-a-half-dimensional source bodies having polygonal cross sections can be constructed using a mouse and keyboard. These bodies can then be adjusted until the calculated gravity and magnetic fields of the source bodies are close to the observed profiles. Auxiliary information such as the topographic surface, bathymetric surface, seismic basement, and geologic contact locations can be displayed on the cross section using optional input files. Test data files, used to demonstrate the source location methods in the report, and several utility programs are included.

A Latent Profile Analysis of Latino Parenting: The Infusion of Cultural Values on Family Conflict

PubMed Central

Ayón, Cecilia; Williams, Lela Rankin; Marsiglia, Flavio F.; Ayers, Stephanie; Kiehne, Elizabeth

2015-01-01

The purpose of the present study was to (a) examine how acculturation and social support inform Latinos’ parenting behaviors, controlling for gender and education; (b) describe parenting styles among Latino immigrants while accounting for cultural elements; and (c) test how these parenting styles are associated with family conflict. A 3 step latent profile analysis with the sample (N = 489) revealed best fit with a 4 profile model (n = 410) of parenting: family parenting (n = 268, 65%), child-centered parenting (n = 68, 17%), moderate parenting (n = 60, 15%), and disciplinarian parenting (n = 14, 3%). Parents’ gender, acculturation, and social support significantly predicted profile membership. Disciplinarian and moderate parenting were associated with more family conflict. Recommendations include integrating culturally based parenting practices as a critical element to family interventions to minimize conflict and promote positive youth development. PMID:26966343

Why evidence-based medicine failed in patient care and medicine-based evidence will succeed.

PubMed

Horwitz, Ralph I; Singer, Burton H

2017-04-01

Evidence-based medicine (EBM) has succeeded in strengthening the evidence base for population medicine. Where EBM has failed is in answering the practicing doctor's question of what a likely outcome would be when a given treatment is administered to a particular patient with her own distinctive biological and biographical (life experience) profile. We propose Medicine-based evidence (MBE), based on the profiles of individual patients, as the evidence base for individualized or personalized medicine. MBE will build an archive of patient profiles using data from all study types and data sources, and will include both clinical and socio-behavioral information. The clinician seeking guidance for the management of an individual patient will start with the patient's longitudinal profile and find approximate matches in the archive that describes how similar patients responded to a contemplated treatment and alternative treatments. Copyright © 2017 Elsevier Inc. All rights reserved.

What's on YOUR Facebook profile? Evaluation of an educational intervention to promote appropriate use of privacy settings by medical students on social networking sites

PubMed Central

Walton, Jennifer M.; White, Jonathan; Ross, Shelley

2015-01-01

Background The rise of social media has led to growing concerns about the potential implications of ‘unprofessional’ postings by physicians and medical students on individuals, institutions, and the medical profession. Relevant and effective guidelines have been difficult to develop and enforce, and there is a need for students and physicians to consider how their online activities may be perceived in the context of their professional roles. The purpose of this project was to examine the Internet presence of a graduating Canadian medical school class by scanning students’ public profiles on the social media site Facebook, incorporate this information into an educational activity addressing professionalism and social media, and evaluate the impact of this activity on student behavior. Methods A systematic search for public Facebook profiles of each member of the class was conducted, and data were collected on the types of publicly visible material. These were presented as part of an educational session on social media and professionalism. One month later, the Facebook search was repeated. Results Of 152 students in the class, profiles were found for 121 (79.8%). The majority of students used appropriately restrictive privacy settings; however, a significant minority had publicly visible information, including comments, photographs, location, and status as a medical student. The educational innovation was well received with more than 90% of students agreeing that this topic was important and well addressed. A follow-up search found that many students had altered their privacy settings to make less information publicly available. Conclusions A small but significant proportion of students share potentially unprofessional content on social media. An interactive educational intervention, which includes specific disclosure of how participants appear to others on social media, resulted in a significant change in student behavior. PMID:26198434

Processes and Outcomes of Developing a Continuity of Care Document for Use as a Personal Health Record by People Living with HIV/AIDS in New York City

PubMed Central

Gordon, Peter; Camhi, Eli; Hesse, Ron; Odlum, Michelle; Schnall, Rebecca; Rodriguez, Martha; Valdez, Esmerlin; Bakken, Suzanne

2015-01-01

Purpose To describe the processes and outcomes of developing and implementing a Continuity of Care Document (CCD), My Health Profile, as personal health record for persons living with HIV (PLWH) in an HIV/AIDS Special Needs Plan (SNP) in New York City. Methods Multiple qualitative and quantitative data sources were used to describe the processes and outcomes of implementing My Health Profile including focus groups, Audio Computer Assisted Self Interview (ACASI) surveys, administrative databases, chart abstraction, usage logs, and project management records. Qualitative data were thematically analyzed. Quantitative data analytic methods included descriptive and multivariate statistics. Data were triangulated and synthesized using the Reach, Efficacy/Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework. Results Reach SNP members are predominantly African American or Hispanic/Latino and about one third are female. A larger proportion of African Americans and smaller proportions of Hispanics/Latinos and Whites were trained to use My Health Profile. Efficacy/Effectiveness CCDs were produced for 8,249 unique members and updated on a monthly basis, 509 members were trained to use My Health Profile. Total number of member logins for 112 active users was 1,808 and the longest duration of use was 1,008 days. There were no significant differences between users and non-users of My Health Profile in clinical outcomes, perceptions of the quality of medical care, or health service utilization. Adoption My Health Profile was well-matched to organizational mission, values, and priorities related to coordination of care for a high-risk population of PLWH. Implementation Pre-implementation focus group participants identified potential barriers to use of My Health Profile including functional and computer literacy, privacy and confidentiality concerns, potential reluctance to use technology, and cognitive challenges. Key strategies for addressing barriers included a dedicated bilingual coach for recruitment, training, and support; basic computer and My Health Profile training; transparent audit trail revealing clinician and case manager access of My Health Profile, time-limited passwords for sharing My Health Profile with others at the point of need, and emergency access mechanism. Maintenance My Health Profile was integrated into routine operational activities and its sustainability is facilitated by its foundation on standards for Health Information Exchange (HIE). Conclusions Although potential barriers exist to the use of PHRs such as My Health Profile, PLWH with complex medical needs, low socioeconomic status, and limited computer experience will use such tools when a sufficient level of user support is provided and privacy and confidentiality concerns are addressed. PMID:22841825

The association between Myers-Briggs Type Indicator and Psychiatry as the specialty choice.

PubMed

Yang, Chong; Richard, George; Durkin, Martin

2016-02-06

The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information. The data includes 835 American medical students who completed the MBTI survey and matched into a residency training program in the United States. All analyses were performed using R 3.1.2. The probability of an introvert matching to a psychiatry residency is no different than that of an extravert (p= 0.30). The probability of an intuitive individual matching to a psychiatry residency is no different than that of a sensing type (p=0.20). The probability of a feeling type matching to a psychiatry residency is no different than that of a thinking type (p= 0.50). The probability of a perceiving type matching to a psychiatry residency is no different than that of a judging type (p= 0.60). Further analyses may elicit more accurate information regarding the personality profile of prospective psychiatry residents. The improvement in communication, team dynamics, mentor-mentee relationships and reduction in workplace conflicts are possible with the awareness of MBTI personality profiles.

The association between Myers-Briggs Type Indicator and Psychiatry as the specialty choice

PubMed Central

Richard, George; Durkin, Martin

2016-01-01

Objectives The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. Methods Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information. The data includes 835 American medical students who completed the MBTI survey and matched into a residency training program in the United States. All analyses were performed using R 3.1.2. Results The probability of an introvert matching to a psychiatry residency is no different than that of an extravert (p= 0.30). The probability of an intuitive individual matching to a psychiatry residency is no different than that of a sensing type (p=0.20). The probability of a feeling type matching to a psychiatry residency is no different than that of a thinking type (p= 0.50). The probability of a perceiving type matching to a psychiatry residency is no different than that of a judging type (p= 0.60). Conclusions Further analyses may elicit more accurate information regarding the personality profile of prospective psychiatry residents. The improvement in communication, team dynamics, mentor-mentee relationships and reduction in workplace conflicts are possible with the awareness of MBTI personality profiles. PMID:26851600

Literature-based compound profiling: application to toxicogenomics.

PubMed

Frijters, Raoul; Verhoeven, Stefan; Alkema, Wynand; van Schaik, René; Polman, Jan

2007-11-01

To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology term and pathway over-representation analyses. The objective of this study was to introduce an additional approach, in which literature information is used for compound profiling to evaluate compound toxicity and mode of toxicity. Gene annotations were built by text mining in Medline abstracts for retrieval of co-publications between genes, pathology terms, biological processes and pathways. This literature information was used to generate compound-specific keyword fingerprints, representing over-represented keywords calculated in a set of regulated genes after compound administration. To see whether keyword fingerprints can be used for assessment of compound toxicity, we analyzed microarray data sets of rat liver treated with 11 hepatotoxicants. Analysis of keyword fingerprints of two genotoxic carcinogens, two nongenotoxic carcinogens, two peroxisome proliferators and two randomly generated gene sets, showed that each compound produced a specific keyword fingerprint that correlated with the experimentally observed histopathological events induced by the individual compounds. By contrast, the random sets produced a flat aspecific keyword profile, indicating that the fingerprints induced by the compounds reflect biological events rather than random noise. A more detailed analysis of the keyword profiles of diethylhexylphthalate, dimethylnitrosamine and methapyrilene (MPy) showed that the differences in the keyword fingerprints of these three compounds are based upon known distinct modes of action. Visualization of MPy-linked keywords and MPy-induced genes in a literature network enabled us to construct a mode of toxicity proposal for MPy, which is in agreement with known effects of MPy in literature. Compound keyword fingerprinting based on information retrieved from literature is a powerful approach for compound profiling, allowing evaluation of compound toxicity and analysis of the mode of action.

Water-quality and lake-stage data for Wisconsin lakes, water year 1996

USGS Publications Warehouse

,

1997-01-01

The purpose of this report is to provide information about the physical and chemical characteristics of Wisconsin lakes. Data that have been collected at specific lakes, and information to aid in the interpretation of those data, are included in this report. Data collected includes measurements of lake stage and in-lake water quality. Graphs of Secchi depths, surface totalphosphorus and chlorophyll-a concentrations versus time are included for lakes with two or more years of data. Graphs of vertical profiles of temperature, dissolved oxygen, pH, and specific conductance are included for sites where these parameters were measured. Descriptive information for each lake includes: location of the lake, drainage area of the lake's watershed, period for which data are available, revisions to previously published records, and pertinent remarks. Additional data, such as streamflow and water quality in tributary and outlet streams of some of the lakes, are published in another volume: "Water Resources Data-Wisconsin, 1996."

Water-quality and lake-stage data for Wisconsin lakes, water year 2005

USGS Publications Warehouse

Rose, W.J.; Garn, H.S.; Goddard, G.L.; Marsh, S.B.; Olson, D.L.; Robertson, Dale M.

2006-01-01

The U.S. Geological Survey (USGS), in cooperation with local and other agencies, collects data at selected lakes throughout Wisconsin. These data, accumulated over many years, provide a data base for developing an improved understanding of the water quality of lakes. The purpose of this report is to provide information about the chemical and physical charac-teristics of Wisconsin lakes. Data that have been collected at specific lakes, and information to aid in the interpretation of those data, are included in this report. Data collected include measure-ments of in-lake water quality and lake stage. Time series graphs of Secchi depths, surface total phosphorus and chlorophyll a concentrations collected during non-frozen periods are included for all lakes. Graphs of vertical profiles of temperature, dissolved oxygen, pH, and specific conductance are included for sites where these parameters were measured. Descriptive infor-mation for each lake includes: location of the lake, area of the lake's watershed, period for which data are available, revisions to previously published records, and pertinent remarks.

Developing technologies for bioacoustic vocal profiling as a viable component of integrative medical diagnostics and treatment

NASA Astrophysics Data System (ADS)

Edwards, Sharry K.

2005-04-01

Over the past 20+ years the pioneering field of Human Bioacoustics, which includes voice spectral analysis, has begun to model the frequencies and architecture of human vocalizations to identify the innate mathematical templates found within the various system of the human body. Using the idea that the voice is a holographic representation of health and wellness, these non-invasive techniques are being advanced to the extent that a computerized Vocal Profile, using a system of Frequency Equivalents, can be used to accurately quantify, organize, interpret, define, and extrapolate biometric information from the human voice. This information, in turn, provides the opportunity to predict, direct, and maintain intrinsic form and function. This novel approach has provided an accumulation of significant data but until recently has been without an efficient biological framework of reference. The emerging Mathematical Model being assembled through Human Bioacoustic research likely has the potential to allow Vocal Profiling to be used to predict and monitor health issues from the very first cries of a newborn through the frequency foundations of disease and aging.

A comparison of protein profiles of cervical tissue homogenate, exfoliated cells from cervix and serum in normal and cervical malignancy conditions.

PubMed

Bhat, Sujatha; Kartha, Vasudevan Bhaskaran; Rai, Lavanya; Chidangil, Santhosh

2015-01-01

Cervical cancer, the second most common cancer in women, progresses silently over long periods before producing any clinical manifestation. Research in early detection of this condition using proteomic techniques is of very recent origin. We used high-performance liquid chromatography combined with laser-induced fluorescence method in our lab to record the protein profiles of tissue homogenate, cell lysate and serum samples of normal and different stages of malignant conditions of the cervix. Information on protein markers in the protein profiles was derived using various data processing methods including curve resolution. The variations in relative intensities of different peaks with respect to peak height, width and area under the curve from different sample types were compared to get information regarding the concentration of the various proteins and their significance in the induction and metastasis of cervical cancer. The method can be used in diagnosis, follow-up with respect to the progression, remission and effective therapy, in cervical malignancy. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling

PubMed Central

Angelastro, James M.; Klimaschewski, Lars; Tang, Song; Vitolo, Ottavio V.; Weissman, Tamily A.; Donlin, Laura T.; Shelanski, Michael L.; Greene, Lloyd A.

2000-01-01

Neurotrophic factors such as nerve growth factor (NGF) promote a wide variety of responses in neurons, including differentiation, survival, plasticity, and repair. Such actions often require changes in gene expression. To identify the regulated genes and thereby to more fully understand the NGF mechanism, we carried out serial analysis of gene expression (SAGE) profiling of transcripts derived from rat PC12 cells before and after NGF-promoted neuronal differentiation. Multiple criteria supported the reliability of the profile. Approximately 157,000 SAGE tags were analyzed, representing at least 21,000 unique transcripts. Of these, nearly 800 were regulated by 6-fold or more in response to NGF. Approximately 150 of the regulated transcripts have been matched to named genes, the majority of which were not previously known to be NGF-responsive. Functional categorization of the regulated genes provides insight into the complex, integrated mechanism by which NGF promotes its multiple actions. It is anticipated that as genomic sequence information accrues the data derived here will continue to provide information about neurotrophic factor mechanisms. PMID:10984536

78 FR 17720 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Worker...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-22

... Employment and Training Administration (ETA) sponsored information collection request (ICR) titled, ``Worker Profiling and Reemployment Services Activities and Worker Profiling and Reemployment Outcomes,'' to the... for OMB Review; Comment Request; Worker Profiling and Reemployment Services Activities and Worker...

Educational and Demographic Profile: Madera County

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2004

2004-01-01

This profile uniquely presents a variety of educational and socioeconomic information for Madera County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

Educational and Demographic Profile: Sonoma County.

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2004

2004-01-01

This profile uniquely presents a variety of educational and socioeconomic information for Sonoma County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. The information provides a framework for enhanced communication and…

Educational and Demographic Profile: Humboldt County.

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2004

2004-01-01

This profile uniquely presents a variety of educational and socioeconomic information for Humboldt County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

Educational and Demographic Profile: Mariposa County.

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2004

2004-01-01

This profile uniquely presents a variety of educational and socioeconomic information for Mariposa County, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for enhanced…

Government Open Systems Interconnection Profile (GOSIP) transition strategy

NASA Astrophysics Data System (ADS)

Laxen, Mark R.

1993-09-01

This thesis analyzes the Government Open Systems Interconnection Profile (GOSIP) and the requirements of the Federal Information Processing Standard (FIPS) Publication 146-1. It begins by examining the International Organization for Standardization (ISO) Open Systems Interconnection (OSI) architecture and protocol suites and the distinctions between GOSIP version one and two. Additionally, it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed their recommendations. Implementation considerations from both government and vendor perspectives illustrate the barriers and requirements faced by information systems managers, as well as basic transition strategies. The result of this thesis is to show a transition strategy through an extended and coordinated period of coexistence due to extensive legacy systems and GOSIP product unavailability. Recommendations for GOSIP protocol standards to include capabilities outside the OSI model are also presented.

Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine.

PubMed

Fang, Yantian; Yao, Qizhi; Chen, Zongyou; Xiang, Jianbin; William, Fisher E; Gibbs, Richard A; Chen, Changyi

2013-10-31

Recent advances in human genomics and biotechnologies have profound impacts on medical research and clinical practice. Individual genomic information, including DNA sequences and gene expression profiles, can be used for prediction, prevention, diagnosis, and treatment for many complex diseases. Personalized medicine attempts to tailor medical care to individual patients by incorporating their genomic information. In a case of pancreatic cancer, the fourth leading cause of cancer death in the United States, alteration in many genes as well as molecular profiles in blood, pancreas tissue, and pancreas juice has recently been discovered to be closely associated with tumorigenesis or prognosis of the cancer. This review aims to summarize recent advances of important genes, proteins, and microRNAs that play a critical role in the pathogenesis of pancreatic cancer, and to provide implications for personalized medicine in pancreatic cancer.

Effects of gender and physical attractiveness on visual attention to Facebook profiles.

PubMed

Seidman, Gwendolyn; Miller, Olivia S

2013-01-01

The current study examined viewers' gaze while observing Facebook profiles of strangers varying in gender and physical attractiveness. Fifty-one participants viewed four Facebook profiles, a physically attractive and unattractive individual of each gender. Participants' eye movements were tracked as they viewed each profile for 60 seconds. Results showed that participants paid more attention to the physical appearance (main profile photograph) of female than of male profile owners and to the personal information (likes and interests) of male than to female profile owners. Participants spent more time focusing on information that was irrelevant to forming an impression of the profile owner (advertisements) when viewing the profiles of unattractive than attractive individuals, suggesting that they made a greater effort to learn about these individuals.

Low-flow profiles of the Tennessee River tributaries in Georgia

USGS Publications Warehouse

Carter, R.F.; Hopkins, E.H.; Perlman, H.A.

1988-01-01

Low flow information is provided for use in an evaluation of the capacity of streams to permit withdrawals or to accept waste loads without exceeding the limits of State water quality standards. The purpose of this report is to present the results of a compilation of available low flow data in the form of tables and ' 7Q10 flow profiles ' (minimum average flow for 7 consecutive days with a 10-yr recurrence interval) (7Q10 flow plotted against distance along a stream channel) for all stream reaches of the Tennessee River tributaries where sufficient data of acceptable accuracy are available. Drainage area profiles are included for all stream basins larger than 5 sq mi, except for those in a few remote areas. This report is the fifth in a series of reports that will cover all stream basins north of the Fall Line in Georgia. It includes the parts of the Tennessee River basin in Georgia. Flow records were not adjusted for diversions or other factors that cause measured flows to represent other than natural flow conditions. The 7-day minimum flow profile was omitted for stream reaches where natural flow was known to be altered significantly. (Lantz-PTT)

Critical review on refractive surgical lasers

NASA Astrophysics Data System (ADS)

Lin, J. T.

1995-03-01

The current status of refractive surgical lasers (including excimer and nonexcimer lasers) is reviewed with an emphasis on photorefractive keratectomy (PRK). The correlation of engineering parameters and the clinical requirements with optimal conditions are presented. The fundamentals of corneal reshaping with formulas for ablation profiles and the advantages of the multizone method are discussed. Updated information on the Mini-Excimer PRK laser system, with an emphasis on the scanning delivery device, is presented. PMMA ablation profiles performed by standard diaphragm and scanning modes are compared for surface ablation quality. Scanning mode ablation patterns for myopia, hyperopia, and regular and irregular astigmatism are presented.

Unsupervised user similarity mining in GSM sensor networks.

PubMed

Shad, Shafqat Ali; Chen, Enhong

2013-01-01

Mobility data has attracted the researchers for the past few years because of its rich context and spatiotemporal nature, where this information can be used for potential applications like early warning system, route prediction, traffic management, advertisement, social networking, and community finding. All the mentioned applications are based on mobility profile building and user trend analysis, where mobility profile building is done through significant places extraction, user's actual movement prediction, and context awareness. However, significant places extraction and user's actual movement prediction for mobility profile building are a trivial task. In this paper, we present the user similarity mining-based methodology through user mobility profile building by using the semantic tagging information provided by user and basic GSM network architecture properties based on unsupervised clustering approach. As the mobility information is in low-level raw form, our proposed methodology successfully converts it to a high-level meaningful information by using the cell-Id location information rather than previously used location capturing methods like GPS, Infrared, and Wifi for profile mining and user similarity mining.

Safety Profile of Biologic Drugs in the Therapy of Ulcerative Colitis: A Systematic Review and Network Meta-Analysis.

PubMed

Moćko, Paweł; Kawalec, Paweł; Pilc, Andrzej

2016-08-01

We compared the safety profile of biologic drugs in patients with moderately to severely active ulcerative colitis (UC). A systematic literature search was performed using Medline (PubMed), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases through February 9, 2016. We included randomized controlled trials (RCTs) that compared the safety of biologic drugs (infliximab, adalimumab, golimumab, and vedolizumab) with one another or with placebo in patients with UC. Two reviewers independently conducted the search and selection of studies and rated the risk of bias in each trial. The network meta-analysis (NMA) was conducted for an induction phase (6-8 weeks) and maintenance phase (52-54 weeks) with a Bayesian hierarchical random effects model in Aggregate Data Drug Information System (ADDIS) software. The PROSPERO registration number was CRD42016032607. Seven RCTs were included in the systematic review with NMA. In the case of the induction phase, the NMA could be conducted for the assessment of the relative safety profile of adalimumab, golimumab, and vedolizumab, and in the case of the maintenance phase of infliximab, adalimumab, golimumab, and vedolizumab. The methodological quality of the included RCTs was evaluated as low risk of bias, but high risk of bias in the case of attrition bias (incomplete outcome data) according to the Cochrane criteria. No significant differences were found in the rate of adverse events in patients treated with the reviewed biologics. Vedolizumab was most likely to have the most favorable safety profile in the induction phase as was infliximab for the maintenance phase. The assessment of the relative safety profile revealed no significant differences between the biologic drugs. Further studies are needed to confirm our findings including head-to-head comparisons between the analyzed biologics. © 2016 Pharmacotherapy Publications, Inc.

Empirically Derived Profiles of Teacher Stress, Burnout, Self-Efficacy, and Coping and Associated Student Outcomes

ERIC Educational Resources Information Center

Herman, Keith C.; Hickmon-Rosa, Jal'et; Reinke, Wendy M.

2018-01-01

Understanding how teacher stress, burnout, coping, and self-efficacy are interrelated can inform preventive and intervention efforts to support teachers. In this study, we explored these constructs to determine their relation to student outcomes, including disruptive behaviors and academic achievement. Participants in this study were 121 teachers…

MDMA (Ecstacy): Useful Information for Health Professionals Involved in Drug Education Programs.

ERIC Educational Resources Information Center

Elk, Carrie

1996-01-01

Provides a brief history of 3,4-ethylenedioxymethamphetamine (MDMA). Presents a summation of current findings and implications including MDMA in drug education. Examines typical dosage, effects, user profile, and therapeutic aspects. Calls for increased research to address the lack of formal scientific data regarding the nature and effects of…

Gas Metal Arc Welding and Flux-Cored Arc Welding. Teacher Edition. Second Edition.

ERIC Educational Resources Information Center

Fortney, Clarence; Gregory, Mike

These instructional materials are designed to improve instruction in Gas Metal Arc Welding (GMAW) and Flux-Cored Arc Welding (FCAW). The following introductory information is included: use of this publication; competency profile; instructional/task analysis; related academic and workplace skills list; tools, materials, and equipment list; and…

Journal Literature Covered by Physics Abstracts in 1965.

ERIC Educational Resources Information Center

Keenan, Stella; Brickwedde, F.G.

A study of the publications of the Physics Journal literature has been made, utilizing the 1965 issues of Physics Abstracts. It is intended to provide a profile of the physics literature and statistical information on physics abstract coverage. It deals with abstracts from serial (journal) publications and includes some 32,000 articles from 495…

The Condition of Education in the Great City Schools. A Statistical Profile 1980-1986.

ERIC Educational Resources Information Center

Council of the Great City Schools, Washington, DC.

This report provides statistical information on the 35 large urban school systems that comprise the Council of Great City Schools. Data are organized into the following categories: (1) enrollment and demographics (including racial composition, children below poverty level, and private school, handicapped, vocational education and limited English…

American Indians. 1970 Census of Population, Subject Reports.

ERIC Educational Resources Information Center

Department of Commerce, Washington, DC.

The in-depth statistical profile of the American Indian's condition today is the most comprehensive ever done on the subject by the Bureau of the Census (U.S. Department of Commerce, Social and Economic Statistics Administration). Presenting information from the 1970 Census of Population and Housing it includes tribal and reservation data and…

The Orientation Student Profile Card: Improving the Collection of Student Demographic Information

ERIC Educational Resources Information Center

Clapp, Marlene; Young, Michael

2010-01-01

Bridgewater State University (BSU) is a public institution that falls under the Carnegie classification of Master's Colleges and Universities. BSU is committed to serving students in the New England region. This student population includes a sizeable number of underrepresented students. BSU is dealing with intense pressure to serve these students…

Profiles: Detailed Analyses of the Foreign Student Population, 1985/86.

ERIC Educational Resources Information Center

Zikopoulos, Marianthi, Ed.

The results of the most recent survey on foreign students in regionally accredited institutions of higher education in the United States are provided. In-depth information is included on such topics as: what proportion of students from a specific country are graduates or undergraduates; what proportion of students in different fields are graduates…

National Profile of Community Colleges: Trends and Statistics, 4th Edition

ERIC Educational Resources Information Center

Phillippe, Kent A.; Sullivan, Leila Gonzalez

2005-01-01

This book offers a national view of trends and statistics related to today's community colleges. The new edition includes completely revised text as well as updates to charts and tables on topics such as enrollment, student outcomes, population, curriculum, faculty, workforce, and financial aid. Informative narrative introduces and provides…

Residential Placements for Students with Disabilities: Practice Trends and the Case of Virginia.

ERIC Educational Resources Information Center

Katsiyannis, Antonis

A study of 14 residential facilities operating schools for children with disabilities in Virginia gathered information on the following topics: (1) nature of operation, profit versus nonprofit, fund-raising activities, plans for future expansion, and affiliations with national chains; (2) student profiles including disabilities served, number of…

A Comparison of Password Techniques for Multilevel Authentication Mechanisms

DTIC Science & Technology

1990-06-01

an individual user’s perceptions, personal interests and personal history . This information is unique to the individual and is neither commonly...a user may associative passwords profile around the Beatles . In this case, cues may include "abbey", "john", "yellow" and "george" and have responses

Professional organisation profile: a sub-Faculty of expedition medicine for Australasia.

PubMed

Leggat, Peter A; Shaw, Marc T M

2010-05-01

A review of the recent foundation by The Australasian College of Tropical Medicine of the Sub-Faculty of Expedition Medicine is presented. Information is given on aims, professional grades of membership, and the various activities of the Sub-Faculty, including publications and scientific meetings. Copyright 2010 Elsevier Ltd. All rights reserved.

Embedding Marketing in International Campus Development: Lessons from UK Universities

ERIC Educational Resources Information Center

Lewis, Vicky

2016-01-01

This paper provides recommendations for embedding a market- and marketing-informed approach within the development process for a new international campus. It includes a brief outline of the current global profile of international campuses (as one form of transnational education) before highlighting the role of marketing at key stages of campus…

Early Childhood: Years of Promise, Parts 1 & 2. Profiles in Education Series. [Videotape].

ERIC Educational Resources Information Center

1998

Noting a Carnegie report pointing out changes in children's lives, including working mothers and poor quality care, this videotape provides educators, librarians, and parents information to help children grow to their fullest potential. The 45-minute video highlights a collaborative early childhood care model in place in Stamford, Connecticut to…

A review of recent developments in flight test techniques at the Ames Research Center, Dryden Flight Research Facility

NASA Technical Reports Server (NTRS)

Layton, G. P.

1984-01-01

New flight test techniques in use at Ames Dryden are reviewed. The use of the pilot in combination with ground and airborne computational capabilities to maximize data return is discussed, including the remotely piloted research vehicle technique for high-risk testing, the remotely augmented vehicle technique for handling qualities research, and use of ground computed flight director information to fly unique profiles such as constant Reynolds number profiles through the transonic flight regime. Techniques used for checkout and design verification of systems-oriented aircraft are discussed, including descriptions of the various simulations, iron bird setups, and vehicle tests. Some newly developed techniques to support the aeronautical research disciplines are discussed, including a new approach to position-error determination, and the use of a large skin friction balance for the measurement of drag caused by various excrescencies.

Unprofessional content on Facebook accounts of US urology residency graduates.

PubMed

Koo, Kevin; Ficko, Zita; Gormley, E Ann

2017-06-01

To characterize unprofessional content on public Facebook accounts of contemporary US urology residency graduates. Facebook was queried with the names of all urologists who graduated from US urology residency programmes in 2015 to identify publicly accessible profiles. Profiles were assessed for unprofessional or potentially objectionable content using a prospectively designed rubric, based on professionalism guidelines by the American Urological Association, the American Medical Association, and the Accreditation Council for Graduate Medical Education. Content authorship (self vs other) was determined, and profiles were reviewed for self-identification as a urologist. Of 281 graduates, 223 (79%) were men and 267 (95%) held MD degrees. A total of 201 graduates (72%) had publicly identifiable Facebook profiles. Of these, 80 profiles (40%) included unprofessional or potentially objectionable content, including 27 profiles (13%) reflecting explicitly unprofessional behaviour, such as depictions of intoxication, uncensored profanity, unlawful behaviour, and confidential patient information. When unprofessional content was found, the content was self-authored in 82% of categories. Among 85 graduates (42%) who self-identified as a urologist on social media, nearly half contained concerning content. No differences in content were found between men and women, MD and DO degree-holders, or those who did or did not identify as a urologist (all P > 0.05). The majority of recent residency graduates had publicly accessible Facebook profiles, and a substantial proportion contained self-authored unprofessional content. Of those identifying as urologists on Facebook, approximately half violated published professionalism guidelines. Greater awareness of trainees' online identities is needed. © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.

Educational and Demographic Profile: Kern County.

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2004

2004-01-01

This profile derived from U.S. Census 2000 data presents educational and socioeconomic information for Kern County, California, nearby counties, and the state. The profile highlights the relationship between various factors that affect the economic well-being of individuals and communities. This presentation of information provides a framework for…

Processed and ultra-processed foods are associated with lower-quality nutrient profiles in children from Colombia.

PubMed

Cornwell, Brittany; Villamor, Eduardo; Mora-Plazas, Mercedes; Marin, Constanza; Monteiro, Carlos A; Baylin, Ana

2018-01-01

To determine if processed and ultra-processed foods consumed by children in Colombia are associated with lower-quality nutrition profiles than less processed foods. We obtained information on sociodemographic and anthropometric variables and dietary information through dietary records and 24 h recalls from a convenience sample of the Bogotá School Children Cohort. Foods were classified into three categories: (i) unprocessed and minimally processed foods, (ii) processed culinary ingredients and (iii) processed and ultra-processed foods. We also examined the combination of unprocessed foods and processed culinary ingredients. Representative sample of children from low- to middle-income families in Bogotá, Colombia. Children aged 5-12 years in 2011 Bogotá School Children Cohort. We found that processed and ultra-processed foods are of lower dietary quality in general. Nutrients that were lower in processed and ultra-processed foods following adjustment for total energy intake included: n-3 PUFA, vitamins A, B12, C and E, Ca and Zn. Nutrients that were higher in energy-adjusted processed and ultra-processed foods compared with unprocessed foods included: Na, sugar and trans-fatty acids, although we also found that some healthy nutrients, including folate and Fe, were higher in processed and ultra-processed foods compared with unprocessed and minimally processed foods. Processed and ultra-processed foods generally have unhealthy nutrition profiles. Our findings suggest the categorization of foods based on processing characteristics is promising for understanding the influence of food processing on children's dietary quality. More studies accounting for the type and degree of food processing are needed.

At a Glance: Forty Schools That Serve Low-Income Students

ERIC Educational Resources Information Center

Independent School, 2016

2016-01-01

This article provides a list of low and no tuition independent schools. Profile information is accurate as of May 2016. Profiles contain student body information, how the school works, the school mission, and contact information. [Online Feature

The role of the microbiology laboratory in guiding formulary decisions.

PubMed

Stratton, C W

1988-08-01

Typically, P & T Committee antibiotic selection criteria have included such factors as cost, pharmacokinetics, side effects profile, spectrum of activity, and relative activity against specific pathogens. The microbiology laboratory can provide the P & T Committee with other useful information to help guide them in making even more appropriate and cost-effective formulary decisions. This information includes specific susceptibility data (including prevalence of pathogens, source of infection [community or nosocomial], anatomical site of isolates, specific unit or service where isolated, type of culture specimen, total number of pathogens in the hospital), resistance trends data, an evaluation of microbiologic data presented in published studies, further data regarding an antimicrobial's spectrum of activity and activity against specific pathogens, and the relevance and limitations of in vitro data. With this information in hand, P & T Committee should be in a much better position to optimize formulary decision-making.

The use of social media and mobile device applications to disseminate natural hazard information by Natural Resources Canada

NASA Astrophysics Data System (ADS)

Bird, A. L.; Ulmi, M.; Majewski, C.; Hayek, K.; Edwards, W.; McCormack, D. A.; Cole, R. T.; de Paor, D. R.

2011-12-01

Public expectation of near-instant and reliable information is constantly rising. Such expectation puts increasing demands on organizations charged with providing the public with information on hazard events in near-real-time, while ensuring quality and accuracy of content. Natural Resources Canada (NRCan) has responded by augmenting existing methods for earthquake information distribution with new and varied methods for relaying natural hazards information. We profile tools now employed operationally by NRCan to distribute earthquake information to emergency measures organizations, news media and the public. Also presented will be an example of a smart-'phone application which includes several tools for natural hazard preparedness and response, supplemented with automated real-time alerts.

Towards a Quality Assessment Method for Learning Preference Profiles in Negotiation

NASA Astrophysics Data System (ADS)

Hindriks, Koen V.; Tykhonov, Dmytro

In automated negotiation, information gained about an opponent's preference profile by means of learning techniques may significantly improve an agent's negotiation performance. It therefore is useful to gain a better understanding of how various negotiation factors influence the quality of learning. The quality of learning techniques in negotiation are typically assessed indirectly by means of comparing the utility levels of agreed outcomes and other more global negotiation parameters. An evaluation of learning based on such general criteria, however, does not provide any insight into the influence of various aspects of negotiation on the quality of the learned model itself. The quality may depend on such aspects as the domain of negotiation, the structure of the preference profiles, the negotiation strategies used by the parties, and others. To gain a better understanding of the performance of proposed learning techniques in the context of negotiation and to be able to assess the potential to improve the performance of such techniques a more systematic assessment method is needed. In this paper we propose such a systematic method to analyse the quality of the information gained about opponent preferences by learning in single-instance negotiations. The method includes measures to assess the quality of a learned preference profile and proposes an experimental setup to analyse the influence of various negotiation aspects on the quality of learning. We apply the method to a Bayesian learning approach for learning an opponent's preference profile and discuss our findings.

Incorporating profile information in community detection for online social networks

NASA Astrophysics Data System (ADS)

Fan, W.; Yeung, K. H.

2014-07-01

Community structure is an important feature in the study of complex networks. It is because nodes of the same community may have similar properties. In this paper we extend two popular community detection methods to partition online social networks. In our extended methods, the profile information of users is used for partitioning. We apply the extended methods in several sample networks of Facebook. Compared with the original methods, the community structures we obtain have higher modularity. Our results indicate that users' profile information is consistent with the community structure of their friendship network to some extent. To the best of our knowledge, this paper is the first to discuss how profile information can be used to improve community detection in online social networks.

Effective trauma center partnerships to address firearm injury: a new paradigm.

PubMed

Richmond, Therese S; Schwab, C William; Riely, Jeaneen; Branas, Charles C; Cheney, Rose; Dunfey, Maura

2004-06-01

Firearm violence is the second leading cause of injury-related death. This study examined the use of local trauma centers as lead organizations in their communities to address firearm injury. Three trauma centers in cities with populations less than 100,000 were linked with a university-based firearm injury research center. A trauma surgeon director and coordinator partnered with communities, recruited and directed advisory boards, established a local firearm injury surveillance system, and informed communities using community-specific profiles. Primary process and outcome measures included completeness of data, development of community-specific profiles, number of data-driven consumer media pieces, number of meetings to inform policy makers, and an analysis of problems encountered. Local trauma centers in smaller communities implemented a firearm injury surveillance system, produced community-specific injury profiles, and engaged community leaders and policy makers to address firearm injury. Community-specific profiles demonstrated consistent firearm suicide rates (6.58-6.82 per 100,000) but variation in firearm homicide rates (1.08-12.5 per 100,000) across sites. There were 63 data-driven media pieces and 18 forums to inform community leaders and policy makers. Completeness of data elements ranged from 57.1% to 100%. Problems experienced were disconnected data sources, multiple data owners, potential for political fallout, limited trauma center data, skills sets of medical professionals, and sustainability. Trauma centers, when provided resources and support, with the model described, can function as lead organizations in partnering with the community to acquire and use community-specific data for local firearm injury prevention.

Social inequalities in health information seeking among young adults in Montreal.

PubMed

Gagné, Thierry; Ghenadenik, Adrian E; Abel, Thomas; Frohlich, Katherine L

2018-06-01

Over their lifecourse, young adults develop different skills and preferences in relationship to the information sources they seek when having questions about health. Health information seeking behaviour (HISB) includes multiple, unequally accessed sources; yet most studies have focused on single sources and did not examine HISB's association with social inequalities. This study explores 'multiple-source' profiles and their association with socioeconomic characteristics. We analyzed cross-sectional data from the Interdisciplinary Study of Inequalities in Smoking involving 2093 young adults recruited in Montreal, Canada, in 2011-2012. We used latent class analysis to create profiles based on responses to questions regarding whether participants sought health professionals, family, friends or the Internet when having questions about health. Using multinomial logistic regression, we examined the associations between profiles and economic, social and cultural capital indicators: financial difficulties and transportation means, friend satisfaction and network size, and individual, mother's, and father's education. Five profiles were found: 'all sources' (42%), 'health professional centred' (29%), 'family only' (14%), 'Internet centred' (14%) and 'no sources' (2%). Participants with a larger social network and higher friend satisfaction were more likely to be in the 'all sources' group. Participants who experienced financial difficulties and completed college/university were less likely to be in the 'family only' group; those whose mother had completed college/university were more likely to be in this group. Our findings point to the importance of considering multiple sources to study HISB, especially when the capacity to seek multiple sources is unequally distributed. Scholars should acknowledge HISB's implications for health inequalities.

RNA-Seq-based transcriptome analysis of dormant flower buds of Chinese cherry (Prunus pseudocerasus).

PubMed

Zhu, Youyin; Li, Yongqiang; Xin, Dedong; Chen, Wenrong; Shao, Xu; Wang, Yue; Guo, Weidong

2015-01-25

Bud dormancy is a critical biological process allowing Chinese cherry (Prunus pseudocerasus) to survive in winter. Due to the lake of genomic information, molecular mechanisms triggering endodormancy release in flower buds have remained unclear. Hence, we used Illumina RNA-Seq technology to carry out de novo transcriptome assembly and digital gene expression profiling of flower buds. Approximately 47million clean reads were assembled into 50,604 sequences with an average length of 837bp. A total of 37,650 unigene sequences were successfully annotated. 128 pathways were annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and metabolic, biosynthesis of second metabolite and plant hormone signal transduction accounted for higher percentage in flower bud. In critical period of endodormancy release, 1644, significantly differentially expressed genes (DEGs) were identified from expression profile. DEGs related to oxidoreductase activity were especially abundant in Gene Ontology (GO) molecular function category. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis demonstrated that DEGs were involved in various metabolic processes, including phytohormone metabolism. Quantitative real-time PCR (qRT-PCR) analysis indicated that levels of DEGs for abscisic acid and gibberellin biosynthesis decreased while the abundance of DEGs encoding their degradation enzymes increased and GID1 was down-regulated. Concomitant with endodormancy release, MADS-box transcription factors including P. pseudocerasus dormancy-associated MADS-box (PpcDAM), Agamous-like2, and APETALA3-like genes, shown remarkably epigenetic roles. The newly generated transcriptome and gene expression profiling data provide valuable genetic information for revealing transcriptomic variation during bud dormancy in Chinese cherry. The uncovered data should be useful for future studies of bud dormancy in Prunus fruit trees lacking genomic information. Copyright © 2014 Elsevier B.V. All rights reserved.

Neuropsychological Profile and Dementia Symptom Recognition in Help-Seekers in a Community Early-Detection Program in Hong Kong.

PubMed

Tang, Jennifer Y-M; Wong, Gloria H-Y; Ng, Carmen K-M; Kwok, Dorothy T-S; Lee, Maggie N-Y; Dai, David L-K; Lum, Terry Y-S

2016-03-01

To examine the neuropsychological and clinical profile of help-seekers in an early-detection community dementia program and to explore any relationship between profiles and time to seek help. Cross-sectional. Early-detection community dementia program. Help-seekers (N = 1,005) with subjective cognitive complaints or complaints from an informant. Neurocognitive testing, including the Cantonese Mini-Mental State Examination (MMSE), Clock Drawing Test, Digit Span, and Fuld Object Memory Evaluation and other clinical and functioning assessments, including the Clinical Dementia Rating (CDR), activities of daily living (ADLs), instrumental ADLs (IADLs), and depressive symptoms. Time since the person or an informant reported that they first noticed symptoms. Eighty-six percent of help-seekers had at least very mild dementia (CDR score ≥0.5). Cognitive performance was moderately impaired (mean MMSE score 18.4 ± 6.1). They required some assistance with IADLs, had very mild ADL impairments, and had few depressive symptoms. Median time to seek assessment was 12 months (interquartile range 7-30 months) according to the person or the informant (an adult child in 75% of the sample). Using the median-split method, time to seek assessment was classified as early (0-12 months) and late (>12 months). Worse cognitive and IADL performance but not ADL performance or depressive symptoms were observed in late than in early help-seekers. Longer time intervals between symptom recognition and early assessment showed a trend of further impairments on all measures except ADLs. A time interval of more than 12 months between symptom recognition and early assessment appears to be associated with worse cognitive function upon presentation. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

Floods of September 15-16, 1992, in the Thompson, Weldon, and Chariton River basins, south-central Iowa

USGS Publications Warehouse

Eash, D.A.; Koppensteiner, B.A.

1997-01-01

Water-surface-elevation profiles and peak discharges for the floods of September 15-16, 1992, in the Thompson, Weldon, and Chariton River Basins, south-central Iowa, are presented in this report. The profiles illustrate the 1992 floods along the Thompson, Weldon, Chariton, and South Fork Chariton Rivers and along Elk Creek in the south-central Iowa counties of Adair, Clarke, Decatur, Lucas, Madison, Ringgold, Union, and Wayne. Water-surface-elevation profiles for the floods of July 4, 1981, along the Chariton River in Lucas County and along the South Fork Chariton River in Wayne County also are included in the report for comparative purposes. The September 15-16, 1992, floods are the largest known peak discharges at gaging stations Thompson River at Davis City (station number 06898000) 57,000 cubic feet per second, Weldon River near Leon (station number 06898400) 76,200 cubic feet per second, Chariton River near Chariton (station number 06903400) 37,700 cubic feet per second, and South Fork Chariton River near Promise City (station number 06903700) 70,600 cubic feet per second. The peak discharges were, respectively, 1.7, 2.6, 1.4, and 2.1 times larger than calculated 100-year recurrence-interval discharges. The report provides information on flood stages and discharges and floodflow frequencies for streamflow-gaging stations in the Thompson, Weldon, and Chariton River Basins using flood information collected through 1995. Information on temporary bench marks and reference points established in the Thompson and Weldon River Basins during 1994-95, and in the Chariton River Basin during 1983-84 and 1994-95, also is included in the report. A flood history summarizes rainfall conditions and damages for floods that occurred during 1947, 1959, 1981, 1992, and 1993.

Flood of July 9-11, 1993, in the Raccoon River basin, west-central Iowa

USGS Publications Warehouse

Eash, D.A.; Koppensteiner, B.A.

1997-01-01

Water-surface-elevation profiles and peak discharges for the flood of July 9-11, 1993, in the Raccoon River Basin, west-central Iowa, are presented in this report. The profiles illustrate the 1993 flood along the Raccoon, North Raccoon, South Raccoon, and Middle Raccoon Rivers and along Brushy and Storm Creeks in the west-central Iowa counties of Carroll, Dallas, Greene, Guthrie, and Polk. Water-surface-elevation profiles for the floods of June 1947, March 1979, and June 29- July 1, 1986, in the Raccoon River Basin also are included in the report for comparative purposes. The July 9-11, 1993, flood is the largest known peak discharge at gaging stations Brushy Creek near Templeton (station number 05483318) 19,000 cubic feet per second, Middle Raccoon River near Bayard (station number 05483450) 27,500 cubic feet per second, Middle Raccoon River at Panora (station number 05483600) 22,400 cubic feet per second, South Raccoon River at Redfield (station number 05484000) 44,000 cubic feet per second, and Raccoon River at Van Meter (station number 05484500) 70,100 cubic feet per second. The peak discharges were, respectively, 1.5, 1.3, 1.1,1.2, and 1.3 times larger than calculated 100-year recurrence-interval discharges. The report provides information on flood stages and discharges and floodflow frequencies for streamflow-gaging stations in the Raccoon River Basin using flood information collected through 1996. A flood history summarizes rainfall conditions and damages for floods that occurred during 1947, 1958, 1979, 1986, 1990, and 1993. Information on temporary bench marks and reference points established in the Raccoon River Basin during 1976-79 and 1995-97 also is included in the report.

A New Technique for Retrieval of Tropospheric and Stratospheric Ozone Profiles using Sky Radiance Measurements at Multiple View Angles: Application to a Brewer Spectrometer

NASA Technical Reports Server (NTRS)

Tzortziou, Maria; Krotkov, Nickolay A.; Cede, Alexander; Herman, Jay R.; Vasilkov, Alexander

2008-01-01

This paper describes and applies a new technique for retrieving diurnal variability in tropospheric ozone vertical distribution using ground-based measurements of ultraviolet sky radiances. The measured radiances are obtained by a polarization-insensitive modified Brewer double spectrometer located at Goddard Space Flight Center, in Greenbelt, Maryland, USA. Results demonstrate that the Brewer angular (0-72deg viewing zenith angle) and spectral (303-320 nm) measurements of sky radiance in the solar principal plane provide sufficient information to derive tropospheric ozone diurnal variability. In addition, the Brewer measurements provide stratospheric ozone vertical distributions at least twice per day near sunrise and sunset. Frequent measurements of total column ozone amounts from direct-sun observations are used as constraints in the retrieval. The vertical ozone profile resolution is shown in terms of averaging kernels to yield at least four points in the troposphere-low stratosphere, including good information in Umkehr layer 0 (0-5 km). The focus of this paper is on the derivation of stratospheric and tropospheric ozone profiles using both simulated and measured radiances. We briefly discuss the necessary modifications of the Brewer spectrometer that were used to eliminate instrumental polarization sensitivity so that accurate sky radiances can be obtained in the presence of strong Rayleigh scattering and aerosols. The results demonstrate that including a site-specific and time-dependent aerosol correction, based on Brewer direct-sun observations of aerosol optical thickness, is critical to minimize the sky radiance residuals as a function of observing angle in the optimal estimation inversion algorithm and improve the accuracy of the retrieved ozone profile.

Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.

PubMed

Van daele, Caroline M; De Meyer, Tim; De Buyzere, Marc L; Gillebert, Thierry C; Denil, Simon L I J; Bekaert, Sofie; Chirinos, Julio A; Segers, Patrick; De Backer, Guy G; De Bacquer, Dirk; Rietzschel, Ernst R

2013-01-01

Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population. Longitudinal population study. Random, representative population sample from Erpe-Mere and Nieuwerkerken (Belgium, primary care). 2524 male/female volunteers, aged 35-55 years, free from overt CVD. Subjects were extensively phenotyped including presence of atherosclerosis (ultrasound) and a newly developed FH questionnaire (4 generations). Compared to cFH, eFH was superior in predicting an adverse risk profile (glycemic state, elevated blood pressure, lipid abnormalities, presence of metabolic syndrome components) and presence of atherosclerosis (all age & sex-adjusted p<0.05). Unlike cFH, eFH remained a significant predictor of subclinical atherosclerosis after adjusting for confounders. Most relations with eFH were not graded but showed clear informational breakpoints, with absence of CVD (including late onset) in any first-degree relative being a negative predictor of atherosclerosis, and a particularly interesting phenotype for further study. A novel, extended FH definition is superior to the conventional definition in profiling cardiovascular risk and atherosclerotic burden in the general population. There remain clear opportunities to refine and increase the performance and informational content of this simple, readily-available inexpensive tool.

Novel lipoprotein density profiling in healthy dogs of various breeds, healthy miniature schnauzers, and miniature schnauzers with hyperlipidemia

PubMed Central

2013-01-01

Background Despite the importance of abnormalities in lipoprotein metabolism in clinical canine medicine, the fact that most previously used methods for lipoprotein profiling are rather laborious and time-consuming has been a major obstacle to the wide clinical application and use of lipoprotein profiling in this species. The aim of the present study was to assess the feasibility of a continuous lipoprotein density profile (CLPDP) generated within a bismuth sodium ethylenediaminetetraacetic acid (NaBiEDTA) density gradient to characterize and compare the lipoprotein profiles of healthy dogs of various breeds, healthy Miniature Schnauzers, and Miniature Schnauzers with primary hypertriacylglycerolemia. A total of 35 healthy dogs of various breeds with serum triacylglycerol (TAG) and cholesterol concentrations within their respective reference intervals were selected for use as a reference population. Thirty-one Miniature Schnauzers with serum TAG and cholesterol concentrations within their respective reference intervals and 31 Miniature Schnauzers with hypertriacylglyceridemia were also included in the study. Results The results suggest that CLPDP using NaBiEDTA provides unique diagnostic information in addition to measurements of serum TAG and cholesterol concentrations and that it is a useful screening method for dogs with suspected lipoprotein metabolism disorders. Using the detailed and continuous density distribution information provided by the CLPDP, important differences in lipoprotein profiles can be detected even among dogs that have serum TAG and cholesterol concentrations within the reference interval. Miniature Schnauzers with serum TAG and cholesterol concentrations within the reference interval had significantly different lipoprotein profiles than dogs of various other breeds. In addition, it was further established that specific lipoprotein fractions are associated with hypertriacylglyceridemia in Miniature Schnauzers. Conclusions The results of the present study suggest that density gradient ultracentrifugation using NaBiEDTA is a useful screening method for the study of lipoprotein profiles in dogs. Therefore, this method could potentially be used for diagnostic purposes for the separation of dogs suspected of having lipoprotein abnormalities from healthy dogs. PMID:23497598

An unsupervised technique for optimal feature selection in attribute profiles for spectral-spatial classification of hyperspectral images

NASA Astrophysics Data System (ADS)

Bhardwaj, Kaushal; Patra, Swarnajyoti

2018-04-01

Inclusion of spatial information along with spectral features play a significant role in classification of remote sensing images. Attribute profiles have already proved their ability to represent spatial information. In order to incorporate proper spatial information, multiple attributes are required and for each attribute large profiles need to be constructed by varying the filter parameter values within a wide range. Thus, the constructed profiles that represent spectral-spatial information of an hyperspectral image have huge dimension which leads to Hughes phenomenon and increases computational burden. To mitigate these problems, this work presents an unsupervised feature selection technique that selects a subset of filtered image from the constructed high dimensional multi-attribute profile which are sufficiently informative to discriminate well among classes. In this regard the proposed technique exploits genetic algorithms (GAs). The fitness function of GAs are defined in an unsupervised way with the help of mutual information. The effectiveness of the proposed technique is assessed using one-against-all support vector machine classifier. The experiments conducted on three hyperspectral data sets show the robustness of the proposed method in terms of computation time and classification accuracy.

Current Abstracts Nuclear Reactors and Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bales, J.D.; Hicks, S.C.

1993-01-01

This publication Nuclear Reactors and Technology (NRT) announces on a monthly basis the current worldwide information available from the open literature on nuclear reactors and technology, including all aspects of power reactors, components and accessories, fuel elements, control systems, and materials. This publication contains the abstracts of DOE reports, journal articles, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database during the past month. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency`smore » Energy Technology Data Exchange or government-to-government agreements. The digests in NRT and other citations to information on nuclear reactors back to 1948 are available for online searching and retrieval on the Energy Science and Technology Database and Nuclear Science Abstracts (NSA) database. Current information, added daily to the Energy Science and Technology Database, is available to DOE and its contractors through the DOE Integrated Technical Information System. Customized profiles can be developed to provide current information to meet each user`s needs.« less

Sequential visibility-graph motifs

NASA Astrophysics Data System (ADS)

Iacovacci, Jacopo; Lacasa, Lucas

2016-04-01

Visibility algorithms transform time series into graphs and encode dynamical information in their topology, paving the way for graph-theoretical time series analysis as well as building a bridge between nonlinear dynamics and network science. In this work we introduce and study the concept of sequential visibility-graph motifs, smaller substructures of n consecutive nodes that appear with characteristic frequencies. We develop a theory to compute in an exact way the motif profiles associated with general classes of deterministic and stochastic dynamics. We find that this simple property is indeed a highly informative and computationally efficient feature capable of distinguishing among different dynamics and robust against noise contamination. We finally confirm that it can be used in practice to perform unsupervised learning, by extracting motif profiles from experimental heart-rate series and being able, accordingly, to disentangle meditative from other relaxation states. Applications of this general theory include the automatic classification and description of physical, biological, and financial time series.

Line-scan spectrum-encoded imaging by dual-comb interferometry.

PubMed

Wang, Chao; Deng, Zejiang; Gu, Chenglin; Liu, Yang; Luo, Daping; Zhu, Zhiwei; Li, Wenxue; Zeng, Heping

2018-04-01

Herein, the method of spectrum-encoded dual-comb interferometry is introduced to measure a three-dimensional (3-D) profile with absolute distance information. By combining spectral encoding for wavelength-to-space mapping, dual-comb interferometry for decoding and optical reference for calibration, this system can obtain a 3-D profile of an object at a stand-off distance of 114 mm with a depth precision of 12 μm. With the help of the reference arm, the absolute distance, reflectivity distribution, and depth information are simultaneously measured at a 5 kHz line-scan rate with free-running carrier-envelope offset frequencies. To verify the concept, experiments are conducted with multiple objects, including a resolution test chart, a three-stair structure, and a designed "ECNU" letter chain. The results show a horizontal resolution of ∼22  μm and a measurement range of 1.93 mm.

A community effort to assess and improve drug sensitivity prediction algorithms

PubMed Central

Costello, James C; Heiser, Laura M; Georgii, Elisabeth; Gönen, Mehmet; Menden, Michael P; Wang, Nicholas J; Bansal, Mukesh; Ammad-ud-din, Muhammad; Hintsanen, Petteri; Khan, Suleiman A; Mpindi, John-Patrick; Kallioniemi, Olli; Honkela, Antti; Aittokallio, Tero; Wennerberg, Krister; Collins, James J; Gallahan, Dan; Singer, Dinah; Saez-Rodriguez, Julio; Kaski, Samuel; Gray, Joe W; Stolovitzky, Gustavo

2015-01-01

Predicting the best treatment strategy from genomic information is a core goal of precision medicine. Here we focus on predicting drug response based on a cohort of genomic, epigenomic and proteomic profiling data sets measured in human breast cancer cell lines. Through a collaborative effort between the National Cancer Institute (NCI) and the Dialogue on Reverse Engineering Assessment and Methods (DREAM) project, we analyzed a total of 44 drug sensitivity prediction algorithms. The top-performing approaches modeled nonlinear relationships and incorporated biological pathway information. We found that gene expression microarrays consistently provided the best predictive power of the individual profiling data sets; however, performance was increased by including multiple, independent data sets. We discuss the innovations underlying the top-performing methodology, Bayesian multitask MKL, and we provide detailed descriptions of all methods. This study establishes benchmarks for drug sensitivity prediction and identifies approaches that can be leveraged for the development of new methods. PMID:24880487

A community effort to assess and improve drug sensitivity prediction algorithms.

PubMed

Costello, James C; Heiser, Laura M; Georgii, Elisabeth; Gönen, Mehmet; Menden, Michael P; Wang, Nicholas J; Bansal, Mukesh; Ammad-ud-din, Muhammad; Hintsanen, Petteri; Khan, Suleiman A; Mpindi, John-Patrick; Kallioniemi, Olli; Honkela, Antti; Aittokallio, Tero; Wennerberg, Krister; Collins, James J; Gallahan, Dan; Singer, Dinah; Saez-Rodriguez, Julio; Kaski, Samuel; Gray, Joe W; Stolovitzky, Gustavo

2014-12-01

Predicting the best treatment strategy from genomic information is a core goal of precision medicine. Here we focus on predicting drug response based on a cohort of genomic, epigenomic and proteomic profiling data sets measured in human breast cancer cell lines. Through a collaborative effort between the National Cancer Institute (NCI) and the Dialogue on Reverse Engineering Assessment and Methods (DREAM) project, we analyzed a total of 44 drug sensitivity prediction algorithms. The top-performing approaches modeled nonlinear relationships and incorporated biological pathway information. We found that gene expression microarrays consistently provided the best predictive power of the individual profiling data sets; however, performance was increased by including multiple, independent data sets. We discuss the innovations underlying the top-performing methodology, Bayesian multitask MKL, and we provide detailed descriptions of all methods. This study establishes benchmarks for drug sensitivity prediction and identifies approaches that can be leveraged for the development of new methods.

Owning genetic information and gene enhancement techniques: why privacy and property rights may undermine social control of the human genome.

PubMed

Moore, A D

2000-04-01

In this article I argue that the proper subjects of intangible property claims include medical records, genetic profiles, and gene enhancement techniques. Coupled with a right to privacy these intangible property rights allow individuals a zone of control that will, in most cases, justifiably exclude governmental or societal invasions into private domains. I argue that the threshold for overriding privacy rights and intangible property rights is higher, in relation to genetic enhancement techniques and sensitive personal information, than is commonly suggested. Once the bar is raised, so-to-speak, the burden of overriding it is formidable. Thus many policy decisions that have been recently proposed or enacted--citywide audio and video surveillance, law enforcement DNA sweeps, genetic profiling, national bans on genetic testing and enhancement of humans, to name a few--will have to be backed by very strong arguments.

Two-dimensional interferometric characterization of laser-induced refractive index profiles in bulk Topas polymer

NASA Astrophysics Data System (ADS)

Hessler, Steffen; Rosenberger, Manuel; Schmauss, Bernhard; Hellmann, Ralf

2018-01-01

In this paper we precisely determine laser-induced refractive index profiles created in cyclic olefin copolymer Topas 6017 employing a sophisticated phase shifting Mach-Zehnder interferometry approach. Beyond the usual one-dimensional modification depth measurement we highlight that for straight waveguide structures also a two-dimensional refractive index distribution can be directly obtained providing full information of a waveguide's exact cross section and its gradient refractive index contrast. Deployed as direct data input in optical waveguide simulation, the evaluated 2D refractive index profiles permit a detailed calculation of the waveguides' actual mode profiles. Furthermore, conventional one-dimensional interferometric measurements for refractive index depth profiles with varying total imposed laser fluence of a 248 nm KrF excimer laser are included to investigate the effect on refractive index modification depth. Maximum surface refractive index increase turns out to attain up to 1.86 ·10-3 enabling laser-written optical waveguide channels. Additionally, a comprehensive optical material characterization in terms of dispersion, thermo-optic coefficient and absorption measurement of unmodified and UV-modified Topas 6017 is carried out.

Integrative Analysis of Longitudinal Metabolomics Data from a Personal Multi-Omics Profile

PubMed Central

Stanberry, Larissa; Mias, George I.; Haynes, Winston; Higdon, Roger; Snyder, Michael; Kolker, Eugene

2013-01-01

The integrative personal omics profile (iPOP) is a pioneering study that combines genomics, transcriptomics, proteomics, metabolomics and autoantibody profiles from a single individual over a 14-month period. The observation period includes two episodes of viral infection: a human rhinovirus and a respiratory syncytial virus. The profile studies give an informative snapshot into the biological functioning of an organism. We hypothesize that pathway expression levels are associated with disease status. To test this hypothesis, we use biological pathways to integrate metabolomics and proteomics iPOP data. The approach computes the pathways’ differential expression levels at each time point, while taking into account the pathway structure and the longitudinal design. The resulting pathway levels show strong association with the disease status. Further, we identify temporal patterns in metabolite expression levels. The changes in metabolite expression levels also appear to be consistent with the disease status. The results of the integrative analysis suggest that changes in biological pathways may be used to predict and monitor the disease. The iPOP experimental design, data acquisition and analysis issues are discussed within the broader context of personal profiling. PMID:24958148

Unsupervised User Similarity Mining in GSM Sensor Networks

PubMed Central

Shad, Shafqat Ali; Chen, Enhong

2013-01-01

Mobility data has attracted the researchers for the past few years because of its rich context and spatiotemporal nature, where this information can be used for potential applications like early warning system, route prediction, traffic management, advertisement, social networking, and community finding. All the mentioned applications are based on mobility profile building and user trend analysis, where mobility profile building is done through significant places extraction, user's actual movement prediction, and context awareness. However, significant places extraction and user's actual movement prediction for mobility profile building are a trivial task. In this paper, we present the user similarity mining-based methodology through user mobility profile building by using the semantic tagging information provided by user and basic GSM network architecture properties based on unsupervised clustering approach. As the mobility information is in low-level raw form, our proposed methodology successfully converts it to a high-level meaningful information by using the cell-Id location information rather than previously used location capturing methods like GPS, Infrared, and Wifi for profile mining and user similarity mining. PMID:23576905

Forensic DNA testing.

PubMed

Butler, John M

2011-12-01

Forensic DNA testing has a number of applications, including parentage testing, identifying human remains from natural or man-made disasters or terrorist attacks, and solving crimes. This article provides background information followed by an overview of the process of forensic DNA testing, including sample collection, DNA extraction, PCR amplification, short tandem repeat (STR) allele separation and sizing, typing and profile interpretation, statistical analysis, and quality assurance. The article concludes with discussions of possible problems with the data and other forensic DNA testing techniques.

Alpha1 LASSO data bundles Lamont, OK

DOE Data Explorer

Gustafson, William Jr; Vogelmann, Andrew; Endo, Satoshi; Toto, Tami; Xiao, Heng; Li, Zhijin; Cheng, Xiaoping; Krishna, Bhargavi (ORCID:000000018828528X)

2016-08-03

A data bundle is a unified package consisting of LASSO LES input and output, observations, evaluation diagnostics, and model skill scores. LES input includes model configuration information and forcing data. LES output includes profile statistics and full domain fields of cloud and environmental variables. Model evaluation data consists of LES output and ARM observations co-registered on the same grid and sampling frequency. Model performance is quantified by skill scores and diagnostics in terms of cloud and environmental variables.

MEDBASE: Strategic Planning and Implementation of an Army Medical Department Software Application

DTIC Science & Technology

2003-07-17

the application. These forms include Department of Defense (DD) Forms 2795, 2796, a more comprehensive version of DD Form 2766, the medical and dental ...include DD Forms 2795, 2796, a more comprehensive version of DD Form 2766, the medical and dental readiness portions of DA Form 7425, and an expanded...Readiness •Mobilization •Aggregation CDA • Dental Readiness TAPDB •Conglomerate Personnel Information MEBITT •Medical Boards •Perm Profiles VISION •Eye

Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

PubMed Central

Pena, Loren D.M.; van Calcar, Sandra C.; Hansen, Joyanna; Edick, Mathew J.; Vockley, Cate Walsh; Leslie, Nancy; Cameron, Cynthia; Mohsen, Al-Walid; Berry, Susan A; Arnold, Georgianne L; Vockley, Jerry

2016-01-01

Very long chain acyl-CoA dehydrogenase (VLCAD) deficiency can present at various ages from the neonatal period to adulthood, and poses the greatest risk of complications during intercurrent illness or after prolonged fasting. Early diagnosis, treatment, and surveillance can reduce mortality; hence, the disorder is included in the newborn Recommended Uniform Screening Panel (RUSP) in the United States. The Inborn Errors of Metabolism Information System (IBEM-IS) was established in 2007 to collect longitudinal information on individuals with inborn errors of metabolism included in newborn screening (NBS) programs, including VLCAD deficiency. We retrospectively analyzed early outcomes for individuals who were diagnosed with VLCAD deficiency by NBS and describe initial presentations, diagnosis, clinical outcomes and treatment in a cohort of 52 individuals ages 1–18 years. Maternal prenatal symptoms were not reported, and most newborns remained asymptomatic. Cardiomyopathy was uncommon in the cohort, diagnosed in 2/52 cases. Elevations in creatine kinase were a common finding, and usually first occurred during the toddler period (1–3 years of age). Diagnostic evaluations required several testing modalities, most commonly plasma acylcarnitine profiles and molecular testing. Functional testing, including fibroblast acylcarnitine profiling and white blood cell or fibroblast enzyme assay, is a useful diagnostic adjunct if uncharacterized mutations are identified. PMID:27209629

The Handbook on the Placement of Foreign Graduate Students (Graduate Handbook, Part III).

ERIC Educational Resources Information Center

National Association for Foreign Student Affairs, Washington, DC.

Information on schooling in 50 countries is provided in the third volume of a handbook on the placement of foreign graduate students. For each country, guidelines concerning placement in U.S. graduate programs are provided. In addition, country profiles cover: years of study included at the primary, secondary, and tertiary levels; diplomas,…

Insider's Guide to Graduate Programs in Clinical and Counseling Psychology. 2006/2007 Edition

ERIC Educational Resources Information Center

Mayne, Tracy J.; Norcross, John C.; Sayette, Michael A.

2006-01-01

Now in its 2006-2007 edition, this perennial bestseller is the resource students count on for the most current information on applying to doctoral programs in clinical or counseling psychology. The Insider's Guide presents up-to-date facts on 300 accredited programs in the United States and Canada. Each program's profile includes admissions…

Regional Data Assimilation of AIRS Profiles and Radiances at the SPoRT Center

NASA Technical Reports Server (NTRS)

Zavodsky, Brad; Chou, Shih-hung; Jedlovec, Gary

2009-01-01

This slide presentation reviews the Short Term Prediction Research and Transition (SPoRT) Center's mission to improve short-term weather prediction at the regional and local scale. It includes information on the cold bias in Weather Research and Forcasting (WRF), troposphere recordings from the Atmospheric Infrared Sounder (AIRS), and vertical resolution of analysis grid.

State Profiles: Financing Public Higher Education. 1978 to 1998 Trend Data.

ERIC Educational Resources Information Center

Halstead, Kent

This report presents two large tables showing trends in the financing of public higher education since 1977-78. Introductory information explains how to use the tables, the data-time relationship (whether fiscal year, academic year, or calendar year), and includes a sample chart constructed from one state's data. The raw data used for these…

Social-Psychological Profiles of Identity Styles: Attitudinal and Social-Cognitive Correlates in Late Adolescence

ERIC Educational Resources Information Center

Soenens, Bart; Duriez, Bart; Goossens, Luc

2005-01-01

This study examined the relationships between three identity styles (i.e. the information style, the normative style, and the diffuse/avoidant style) and a number of social-cognitive and attitudinal variables (including empathy, prejudice, and conservatism). Discriminant analysis on a sample of late adolescents (N=393) led to the conclusion that…

Income, Language, and Citizenship Status: Factors Affecting the Health Care Access and Utilization of Chinese Americans.

ERIC Educational Resources Information Center

Jang, Michael; Lee, Evelyn; Woo, Kent

1998-01-01

The effects of income, language, and citizenship on the use of health-care services by Chinese Americans is examined (N=1808). Focus groups, a telephone survey, and key informant interviews were conducted. Data analysis included an acculturation index, demographic profile, and logistical regression. Health insurance and social factors are…

Anchorage School District Profile of Performance 1996-97. Assessment and Evaluation Report #97-3.

ERIC Educational Resources Information Center

Fenton, Ray

This report focuses on student achievement across the Anchorage (Alaska) school district and within its individual programs. It does not include information on the social and physical wellness of the district's students. The first section of the report provides an overview of district performance on critical achievement indicators, and the second…

OkCupid Data for Introductory Statistics and Data Science Courses

ERIC Educational Resources Information Center

Kim, Albert Y.; Escobedo-Land, Adriana

2015-01-01

We present a data set consisting of user profile data for 59,946 San Francisco OkCupid users (a free online dating website) from June 2012. The data set includes typical user information, lifestyle variables, and text responses to 10 essay questions. We present four example analyses suitable for use in undergraduate introductory probability and…

76 FR 81471 - Agency Information Collection Activities: Proposed Collection; Comment Request-Special...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... Children (WIC) Forms: FNS-698, FNS-699, and FNS-700; The Integrity Profile (TIP) AGENCY: Food and Nutrition..., including the validity of the methodology and assumptions used; (c) ways to enhance the quality, utility and... Marianas, and the Virgin Islands. The reporting burden consists of three automated forms, the FNS-698, FNS...

Processes and outcomes of developing a continuity of care document for use as a personal health record by people living with HIV/AIDS in New York City.

PubMed

Gordon, Peter; Camhi, Eli; Hesse, Ron; Odlum, Michelle; Schnall, Rebecca; Rodriguez, Martha; Valdez, Esmerlin; Bakken, Suzanne

2012-10-01

To describe the processes and outcomes of developing and implementing a Continuity of Care Document (CCD), My Health Profile, as a personal health record for persons living with HIV (PLWH) in an HIV/AIDS Special Needs Plan in New York City. Multiple qualitative and quantitative data sources were used to describe the processes and outcomes of implementing My Health Profile including focus groups, Audio Computer Assisted Self Interview (ACASI) surveys, administrative databases, chart abstraction, usage logs, and project management records. Qualitative data were thematically analyzed. Quantitative data analytic methods included descriptive and multivariate statistics. Data were triangulated and synthesized using the Reach, Efficacy/Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework. Reach - SNP members are predominantly African American or Hispanic/Latino and about one-third are female. A larger proportion of African Americans and smaller proportions of Hispanics/Latinos and Whites were trained to use My Health Profile.Efficacy/Effectiveness - CCDs were produced for 8249 unique members and updated on a monthly basis, 509 members were trained to use My Health Profile. Total number of member logins for 112 active users was 1808 and the longest duration of use was 1008 days. There were no significant differences between users and non-users of My Health Profile in clinical outcomes, perceptions of the quality of medical care, or health service utilization. Adoption -My Health Profile was well-matched to organizational mission, values, and priorities related to coordination of care for a high-risk population of PLWH. Implementation - Pre-implementation focus group participants identified potential barriers to use of My Health Profile including functional and computer literacy, privacy and confidentiality concerns, potential reluctance to use technology, and cognitive challenges. Key strategies for addressing barriers included a dedicated bilingual coach for recruitment, training, and support; basic computer and My Health Profile training; transparent audit trail revealing clinician and case manager access of My Health Profile, time-limited passwords for sharing My Health Profile with others at the point of need, and emergency access mechanism. Maintenance -My Health Profile was integrated into routine operational activities and its sustainability is facilitated by its foundation on standards for Health Information Exchange (HIE). Although potential barriers exist to the use of personal health records (PHRs) such as My Health Profile, PLWH with complex medical needs, low socioeconomic status, and limited computer experience will use such tools when a sufficient level of user support is provided and privacy and confidentiality concerns are addressed. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Multi-profile Bayesian alignment model for LC-MS data analysis with integration of internal standards

PubMed Central

Tsai, Tsung-Heng; Tadesse, Mahlet G.; Di Poto, Cristina; Pannell, Lewis K.; Mechref, Yehia; Wang, Yue; Ressom, Habtom W.

2013-01-01

Motivation: Liquid chromatography-mass spectrometry (LC-MS) has been widely used for profiling expression levels of biomolecules in various ‘-omic’ studies including proteomics, metabolomics and glycomics. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time (RT) alignment, which is required to ensure that ion intensity measurements among multiple LC-MS runs are comparable, is one of the most important yet challenging preprocessing steps. Current alignment approaches estimate RT variability using either single chromatograms or detected peaks, but do not simultaneously take into account the complementary information embedded in the entire LC-MS data. Results: We propose a Bayesian alignment model for LC-MS data analysis. The alignment model provides estimates of the RT variability along with uncertainty measures. The model enables integration of multiple sources of information including internal standards and clustered chromatograms in a mathematically rigorous framework. We apply the model to LC-MS metabolomic, proteomic and glycomic data. The performance of the model is evaluated based on ground-truth data, by measuring correlation of variation, RT difference across runs and peak-matching performance. We demonstrate that Bayesian alignment model improves significantly the RT alignment performance through appropriate integration of relevant information. Availability and implementation: MATLAB code, raw and preprocessed LC-MS data are available at http://omics.georgetown.edu/alignLCMS.html Contact: hwr@georgetown.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:24013927

The physical therapy profile questionnaire (PTPQ): development, validation and pilot testing.

PubMed

Dizon, Janine Margarita R; Grimmer-Somers, Karen; Kumar, Saravana

2011-09-19

Country by country similarities and differences in physical therapy practice exists. Therefore, before updates in practice can be provided, such as trainings in evidence-based practice, it is necessary to identify the profile and nature of practice in a given country or setting. Following a search of the international literature, no appropriate tool was identified to collect and establish data to create the profile of physical therapy practice in the Philippines. We therefore developed, validated and pilot tested a survey instrument which would comprehensively describe the practice of physical therapy in the Philippines We used a mixed methods design to answer our study aims. A focus group interview was conducted among a group of physical therapists to establish the content and contexts of items to be included in the survey instrument. Findings were amalgamated with the information from the literature on developing survey instruments/questionnaires. A survey instrument was drafted and named as the Physical Therapy Profile Questionnaire (PTPQ). The PTPQ was then validated and pilot tested to a different group of physical therapists.The final version consisted of five separate parts namely (A) General information and demographics, (B) Practice Profile, (C) Treatment Preferences, (D) Bases for clinical work and (E) Bases for educational/research work. At present the PTPQ is relevant to the Philippines and could be used by any country which has a similar nature of practice with the Philippines. The Physical Therapy Practice Questionnaire (PTPQ) was shown to have good face and content validity among the Filipino physical therapists and their context of practice. It has also been found to be useful, easy to administer tool and in a format appealing to respondents. The PTPQ is expected to assist comprehensive data collection to create a profile of physical therapy practice in the Philippines.

Comprehensive two-dimensional gas chromatography applied to illicit drug analysis.

PubMed

Mitrevski, Blagoj; Wynne, Paul; Marriott, Philip J

2011-11-01

Multidimensional gas chromatography (MDGC), and especially its latest incarnation--comprehensive two-dimensional gas chromatography (GC × GC)--have proved advantageous over and above classic one-dimensional gas chromatography (1D GC) in many areas of analysis by offering improved peak capacity, often enhanced sensitivity and, especially in the case of GC × GC, the unique feature of 'structured' chromatograms. This article reviews recent advances in MDGC and GC × GC in drug analysis with special focus on ecstasy, heroin and cocaine profiling. Although 1D GC is still the method of choice for drug profiling in most laboratories because of its simplicity and instrument availability, GC × GC is a tempting proposition for this purpose because of its ability to generate a higher net information content. Effluent refocusing due to the modulation (compression) process, combined with the separation on two 'orthogonal' columns, results in more components being well resolved and therefore being analytically and statistically useful to the profile. The spread of the components in the two-dimensional plots is strongly dependent on the extent of retention 'orthogonality' (i.e. the extent to which the two phases possess different or independent retention mechanisms towards sample constituents) between the two columns. The benefits of 'information-driven' drug profiling, where more points of reference are usually required for sample differentiation, are discussed. In addition, several limitations in application of MDGC in drug profiling, including data acquisition rate, column temperature limit, column phase orthogonality and chiral separation, are considered and discussed. Although the review focuses on the articles published in the last decade, a brief chronological preview of the profiling methods used throughout the last three decades is given.

Cell-specific prediction and application of drug-induced gene expression profiles.

PubMed

Hodos, Rachel; Zhang, Ping; Lee, Hao-Chih; Duan, Qiaonan; Wang, Zichen; Clark, Neil R; Ma'ayan, Avi; Wang, Fei; Kidd, Brian; Hu, Jianying; Sontag, David; Dudley, Joel

2018-01-01

Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. However, limited data availability across cell types has hindered our capacity to leverage or explore the cell-specificity of these perturbations. While recent efforts have generated a large number of drug perturbation profiles across a variety of human cell types, many gaps remain in this combinatorial drug-cell space. Hence, we asked whether it is possible to fill these gaps by predicting cell-specific drug perturbation profiles using available expression data from related conditions--i.e. from other drugs and cell types. We developed a computational framework that first arranges existing profiles into a three-dimensional array (or tensor) indexed by drugs, genes, and cell types, and then uses either local (nearest-neighbors) or global (tensor completion) information to predict unmeasured profiles. We evaluate prediction accuracy using a variety of metrics, and find that the two methods have complementary performance, each superior in different regions in the drug-cell space. Predictions achieve correlations of 0.68 with true values, and maintain accurate differentially expressed genes (AUC 0.81). Finally, we demonstrate that the predicted profiles add value for making downstream associations with drug targets and therapeutic classes.

Cell-specific prediction and application of drug-induced gene expression profiles

PubMed Central

Hodos, Rachel; Zhang, Ping; Lee, Hao-Chih; Duan, Qiaonan; Wang, Zichen; Clark, Neil R.; Ma'ayan, Avi; Wang, Fei; Kidd, Brian; Hu, Jianying; Sontag, David

2017-01-01

Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. However, limited data availability across cell types has hindered our capacity to leverage or explore the cell-specificity of these perturbations. While recent efforts have generated a large number of drug perturbation profiles across a variety of human cell types, many gaps remain in this combinatorial drug-cell space. Hence, we asked whether it is possible to fill these gaps by predicting cell-specific drug perturbation profiles using available expression data from related conditions--i.e. from other drugs and cell types. We developed a computational framework that first arranges existing profiles into a three-dimensional array (or tensor) indexed by drugs, genes, and cell types, and then uses either local (nearest-neighbors) or global (tensor completion) information to predict unmeasured profiles. We evaluate prediction accuracy using a variety of metrics, and find that the two methods have complementary performance, each superior in different regions in the drug-cell space. Predictions achieve correlations of 0.68 with true values, and maintain accurate differentially expressed genes (AUC 0.81). Finally, we demonstrate that the predicted profiles add value for making downstream associations with drug targets and therapeutic classes. PMID:29218867

[The interpreter in an intercultural clinical milieu].

PubMed

Vissandjée, B; Ntetu, A L; Courville, F; Breton, E R; Bourdeau, M

1998-05-01

The public's diversified language profile means that nursing practice must adjust to provide the same quality of care to all clients, no matter what language they speak. To improve quality and quantity of information exchanged in the nurse-client-interpreter triangle, the authors have investigated the type of information likely to be filtered and studied the various factors underlying the interpreter's choice to filter information. The authors also analyzed the values interpreters assign to information and the factors that form the background for filtering, including mistrust. The authors suggest adequately preparing interpreters; using interpreters' expertise; and developing an appropriate training program for intercultural interpreters to enable them to better function within health care institutions.

NASA EOSDIS: Enabling Science by Improving User Knowledge

NASA Technical Reports Server (NTRS)

Lindsay, Francis; Brennan, Jennifer; Blumenfeld, Joshua

2016-01-01

Lessons learned and impacts of applying these newer methods are explained and include several examples from our current efforts such as the interactive, on-line webinars focusing on data discovery and access including tool usage, informal and informative data chats with data experts across our EOSDIS community, data user profile interviews with scientists actively using EOSDIS data in their research, and improved conference and meeting interactions via EOSDIS data interactively used during hyper-wall talks and Worldview application. The suite of internet-based, interactive capabilities and technologies has allowed our project to expand our user community by making the data and applications from numerous Earth science missions more engaging, approachable and meaningful.

State Profiles of the State-Administered Adult Education Program for Program Year 1988.

ERIC Educational Resources Information Center

Office of Vocational and Adult Education (ED), Washington, DC. Clearinghouse on Adult Education and Literacy.

These state profiles for Program Year 1988 contain information based on 1980 Census data and information taken from the Annual Financial and Statistical Reports submitted to the Department of Education by the states, Puerto Rico, and the Virgin Islands. State profiles are arranged alphabetically by state. For each state, these demographic…

National Profiles in Technical and Vocational Education in Asia and the Pacific: Fiji.

ERIC Educational Resources Information Center

United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

This technical and vocational education (TVE) profile on Fiji is one in a series of profiles of UNESCO member countries. It is intended to be a handy reference on TVE systems, staff development, technical cooperation, and information networking. Part I, General Information, covers the following: location, area, and physical features; economic and…

An Ontology-Based Tourism Recommender System Based on Spreading Activation Model

NASA Astrophysics Data System (ADS)

Bahramian, Z.; Abbaspour, R. Ali

2015-12-01

A tourist has time and budget limitations; hence, he needs to select points of interest (POIs) optimally. Since the available information about POIs is overloading, it is difficult for a tourist to select the most appreciate ones considering preferences. In this paper, a new travel recommender system is proposed to overcome information overload problem. A recommender system (RS) evaluates the overwhelming number of POIs and provides personalized recommendations to users based on their preferences. A content-based recommendation system is proposed, which uses the information about the user's preferences and POIs and calculates a degree of similarity between them. It selects POIs, which have highest similarity with the user's preferences. The proposed content-based recommender system is enhanced using the ontological information about tourism domain to represent both the user profile and the recommendable POIs. The proposed ontology-based recommendation process is performed in three steps including: ontology-based content analyzer, ontology-based profile learner, and ontology-based filtering component. User's feedback adapts the user's preferences using Spreading Activation (SA) strategy. It shows the proposed recommender system is effective and improves the overall performance of the traditional content-based recommender systems.

Four-dimensional characterization of a sheet-forming web

DOEpatents

Sari-Sarraf, Hamed; Goddard, James S.

2003-04-22

A method and apparatus are provided by which a sheet-forming web may be characterized in four dimensions. Light images of the web are recorded at a point adjacent the initial stage of the web, for example, near the headbox in a paperforming operation. The images are digitized, and the resulting data is processed by novel algorithms to provide a four-dimensional measurement of the web. The measurements include two-dimensional spatial information, the intensity profile of the web, and the depth profile of the web. These measurements can be used to characterize the web, predict its properties and monitor production events, and to analyze and quantify headbox flow dynamics.

A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database

PubMed Central

Yoo, Seong Yeon; Cho, Nam Soo; Park, Myung Jin; Seong, Ki Min; Hwang, Jung Ho; Song, Seok Bean; Han, Myun Soo; Lee, Won Tae; Chung, Ki Wha

2011-01-01

Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently established by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 × 10-17. This large STR profile dataset including atypical alleles will be important for the establishment of the Korean DNA database and for forensic applications. PMID:21597912

Atmospheric turbulence profiling with unknown power spectral density

NASA Astrophysics Data System (ADS)

Helin, Tapio; Kindermann, Stefan; Lehtonen, Jonatan; Ramlau, Ronny

2018-04-01

Adaptive optics (AO) is a technology in modern ground-based optical telescopes to compensate for the wavefront distortions caused by atmospheric turbulence. One method that allows to retrieve information about the atmosphere from telescope data is so-called SLODAR, where the atmospheric turbulence profile is estimated based on correlation data of Shack-Hartmann wavefront measurements. This approach relies on a layered Kolmogorov turbulence model. In this article, we propose a novel extension of the SLODAR concept by including a general non-Kolmogorov turbulence layer close to the ground with an unknown power spectral density. We prove that the joint estimation problem of the turbulence profile above ground simultaneously with the unknown power spectral density at the ground is ill-posed and propose three numerical reconstruction methods. We demonstrate by numerical simulations that our methods lead to substantial improvements in the turbulence profile reconstruction compared to the standard SLODAR-type approach. Also, our methods can accurately locate local perturbations in non-Kolmogorov power spectral densities.

A large population genetic study of 15 autosomal short tandem repeat loci for establishment of Korean DNA profile database.

PubMed

Yoo, Seong Yeon; Cho, Nam Soo; Park, Myung Jin; Seong, Ki Min; Hwang, Jung Ho; Song, Seok Bean; Han, Myun Soo; Lee, Won Tae; Chung, Ki Wha

2011-07-01

Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently established by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 × 10(-17). This large STR profile dataset including atypical alleles will be important for the establishment of the Korean DNA database and for forensic applications.

Muscle profiling to improve the value of retail meat cuts.

PubMed

Jung, E Y; Hwang, Y H; Joo, S T

2016-10-01

Nutrition and meat quality are always important to consumers, but vary by individual muscle or muscle groups in retail meat cuts. Muscle profiling of nutrient content and palatability for all retail beef cuts is necessary to suggest healthy and tasty beef cuts and to inform consumers of the benefits of beef consumption. The current paper reviews numerous studies that provide muscle profiles for nutrients and palatability attributes of muscles or muscle groups in retail beef cuts. The composition of nutrients including protein, fat, moisture, vitamins, and minerals in beef cuts is documented as well as the nutritive role as a part of a healthy diet. In addition, this review presents knowledge in relation to innovative carcass fabrication and value-added cuts to improve the value of beef carcass. Finally, the current work emphasize the palatability assessment of individual beef muscles, and concludes that all retail beef cuts should be merchandised for proper cooking according to the palatability profiles of beef muscles. Copyright © 2016 Elsevier Ltd. All rights reserved.

A high-throughput microRNA expression profiling system.

PubMed

Guo, Yanwen; Mastriano, Stephen; Lu, Jun

2014-01-01

As small noncoding RNAs, microRNAs (miRNAs) regulate diverse biological functions, including physiological and pathological processes. The expression and deregulation of miRNA levels contain rich information with diagnostic and prognostic relevance and can reflect pharmacological responses. The increasing interest in miRNA-related research demands global miRNA expression profiling on large numbers of samples. We describe here a robust protocol that supports high-throughput sample labeling and detection on hundreds of samples simultaneously. This method employs 96-well-based miRNA capturing from total RNA samples and on-site biochemical reactions, coupled with bead-based detection in 96-well format for hundreds of miRNAs per sample. With low-cost, high-throughput, high detection specificity, and flexibility to profile both small and large numbers of samples, this protocol can be adapted in a wide range of laboratory settings.

Road profiling of traffic accidents in Jos, Nigeria, 1995-1999.

PubMed

Bombom, Leonard S; Edino, Marcus O

2009-09-01

Road traffic accident data in Nigeria generally lack exact coordinate information. Accident analysis is, therefore, restricted to aggregate data on trends, magnitude and temporal dimensions. This article addresses the road accident problem in Jos between 1995 and 1999 through a road profiling approach. Results show that four gateway routes, seven multi-lane roadways (including two gateway routes) and seven road intersections accounted for 84% of all traffic accidents, 84% of injured casualties and 88% of fatalities. This approach allows for quantification of impacts of controlling for accidents by deliberate profiling of roads for close monitoring and policing. For example, reducing accident counts and fatalities by 50% each on gateway routes will amount to approximately 35 and 40% reduction in accident and fatality counts, respectively. Countermeasures must consider these roadways and intersections as important inputs in their accidents and casualty reduction targets.

Improved upper winds models for several astronomical observatories.

PubMed

Roberts, Lewis C; Bradford, L William

2011-01-17

An understanding of wind speed and direction as a function of height are critical to the proper modeling of atmospheric turbulence. We have used radiosonde data from launch sites near significant astronomical observatories and created averaged profiles of wind speed and direction and have also computed Richardson number profiles. Using data from the last 30 years, we confirm a 1977 Greenwood wind profile, and extend it to include parameters that show seasonal variations and differences in location. The added information from our models is useful for the design of adaptive optics systems and other imaging systems. Our analysis of the Richardson number suggests that persistent turbulent layers may be inferred when low values are present in our long term averaged data. Knowledge of the presence of these layers may help with planning for adaptive optics and laser communications.

76 FR 34062 - Patent and Trademark Financial Transactions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... payments by completing a Deposit Account Application Form (PTO-2232) and sending the required information... Profile, customers may then add the relevant account information to the profile in order to track their... public and other Federal agencies to take this opportunity to comment on the continuing information...

Size–strain separation in diffraction line profile analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scardi, P.; Ermrich, M.; Fitch, A.

Separation of size and strain effects on diffraction line profiles has been studied in a round robin involving laboratory instruments and synchrotron radiation beamlines operating with different radiation, optics, detectors and experimental configurations. The studied sample, an extensively ball milled iron alloy powder, provides an ideal test case, as domain size broadening and strain broadening are of comparable size. The high energy available at some synchrotron radiation beamlines provides the best conditions for an accurate analysis of the line profiles, as the size–strain separation clearly benefits from a large number of Bragg peaks in the pattern; high counts, reliable intensitymore » values in low-absorption conditions, smooth background and data collection at different temperatures also support the possibility to include diffuse scattering in the analysis, for the most reliable assessment of the line broadening effect. However, results of the round robin show that good quality information on domain size distribution and microstrain can also be obtained using standard laboratory equipment, even when patterns include relatively few Bragg peaks, provided that the data are of good quality in terms of high counts and low and smooth background.« less

Size–strain separation in diffraction line profile analysis

DOE PAGES

Scardi, P.; Ermrich, M.; Fitch, A.; ...

2018-05-29

Separation of size and strain effects on diffraction line profiles has been studied in a round robin involving laboratory instruments and synchrotron radiation beamlines operating with different radiation, optics, detectors and experimental configurations. The studied sample, an extensively ball milled iron alloy powder, provides an ideal test case, as domain size broadening and strain broadening are of comparable size. The high energy available at some synchrotron radiation beamlines provides the best conditions for an accurate analysis of the line profiles, as the size–strain separation clearly benefits from a large number of Bragg peaks in the pattern; high counts, reliable intensitymore » values in low-absorption conditions, smooth background and data collection at different temperatures also support the possibility to include diffuse scattering in the analysis, for the most reliable assessment of the line broadening effect. However, results of the round robin show that good quality information on domain size distribution and microstrain can also be obtained using standard laboratory equipment, even when patterns include relatively few Bragg peaks, provided that the data are of good quality in terms of high counts and low and smooth background.« less

D2R2: an evidence-based decision support tool to aid prioritisation of animal health issues for government funding.

PubMed

Gibbens, J C; Frost, A J; Houston, C W; Lester, H; Gauntlett, F A

2016-11-26

An evidence-based decision support tool, 'D2R2', has been developed by Defra. It contains a wide range of standardised information about exotic and endemic diseases held in 'disease profiles'. Each profile includes 40 criteria used for scoring, enabling D2R2 to provide relative priority rankings for every disease profiled. D2R2 also provides a range of reports for each disease and the functionality to explore the impact of changes in any criterion or weighting on a disease's ranking. These outputs aid the prioritisation and management of animal diseases by government. D2R2 was developed with wide stakeholder engagement and its design was guided by clear specifications. It uses the weighted scores of a limited number of criteria to generate impact and risk scores for each disease, and relies on evidence drawn from published material wherever possible and maintained up to date. It allows efficient use of expertise, as maintained disease profiles reduce the need for on call, reactive, expert input for policy development and enables rapid simultaneous access to the same information by multiple parties, for example during exotic disease outbreaks. The experience in developing D2R2 has been shared internationally to assist others with their development of disease prioritisation and categorisation systems. British Veterinary Association.

Eta Carinae and the Homunculus: An Astrophysical Laboratory

NASA Technical Reports Server (NTRS)

Gull, Theodore R.

2006-01-01

High spatial resolution spectroscopy with HST/STIS between 1998.0 and 2004.2 has provided much exciting information about the central binary system and the physics of its N-rich, C,O-poor ejecta. Stellar He I profiles, noticeably blue-shifted relative to P Cygni H and Fe II line profiles, originate from the ionized wind region between two massive companions. Changes in profiles of He I singlet and triplet lines provide clues to the excitation mechanisms involved as the hot, UV companion moves in its highly eccentric orbit. For 90% of the 5.54-year period, the spectra of nearby Weigelt blobs and the Little Homunculus include highly excited emission lines of Ar, Ne, and Fe. During the few month-long spectroscopic minimum, these systems are deprived of Lyman continuum. Recombination, plus cooling, occurs. In the skirt region between the bipolar Homunculus, a neutral emission region, devoid of hydrogen emission, glows in Ti II, Fe I, Sr II, Sc II, etc. We find the ejecta to have Ti/Ni abundances nearly 100 times solar, not due to nuclear processing, but due to lack of oxygen. Many metals normally tied up in interstellar dust remain in gaseous phase. Much information is being obtained on the physical processes in these warm N-rich gases, whose excitation varies with time in a predictable pattern. Indeed recent GRB high dispersion spectra include signatures of circumGRB warm gases. This indicates that the early, primordial massive stars have warm massive ejecta reminiscent to that around Eta Carinae.

OP17MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS

PubMed Central

Jeyapalan, Jennie N.; Jones, Tania A.; Tatevossian, Ruth G.; Qaddoumi, Ibrahim; Ellison, David W.; Sheer, Denise

2014-01-01

INTRODUCTION: MicroRNAs regulate gene expression by targeting mRNAs for translational repression or degradation at the post-transcriptional level. In paediatric low-grade gliomas a few key genetic mutations have been identified, including BRAF fusions, FGFR1 duplications and MYB rearrangements. Our aim in the current study is to profile aberrant microRNA expression in paediatric low-grade gliomas and determine the role of epigenetic changes in the aetiology and behaviour of these tumours. METHOD: MicroRNA profiling of tumour samples (6 pilocytic, 2 diffuse, 2 pilomyxoid astrocytomas) and normal brain controls (4 adult normal brain samples and a primary glial progenitor cell-line) was performed using small RNA sequencing. Bioinformatic analysis included sequence alignment, analysis of the number of reads (CPM, counts per million) and differential expression. RESULTS: Sequence alignment identified 695 microRNAs, whose expression was compared in tumours v. normal brain. PCA and hierarchical clustering showed separate groups for tumours and normal brain. Computational analysis identified approximately 400 differentially expressed microRNAs in the tumours compared to matched location controls. Our findings will then be validated and integrated with extensive genetic and epigenetic information we have previously obtained for the full tumour cohort. CONCLUSION: We have identified microRNAs that are differentially expressed in paediatric low-grade gliomas. As microRNAs are known to target genes involved in the initiation and progression of cancer, they provide critical information on tumour pathogenesis and are an important class of biomarkers.

Accelerating Information Retrieval from Profile Hidden Markov Model Databases.

PubMed

Tamimi, Ahmad; Ashhab, Yaqoub; Tamimi, Hashem

2016-01-01

Profile Hidden Markov Model (Profile-HMM) is an efficient statistical approach to represent protein families. Currently, several databases maintain valuable protein sequence information as profile-HMMs. There is an increasing interest to improve the efficiency of searching Profile-HMM databases to detect sequence-profile or profile-profile homology. However, most efforts to enhance searching efficiency have been focusing on improving the alignment algorithms. Although the performance of these algorithms is fairly acceptable, the growing size of these databases, as well as the increasing demand for using batch query searching approach, are strong motivations that call for further enhancement of information retrieval from profile-HMM databases. This work presents a heuristic method to accelerate the current profile-HMM homology searching approaches. The method works by cluster-based remodeling of the database to reduce the search space, rather than focusing on the alignment algorithms. Using different clustering techniques, 4284 TIGRFAMs profiles were clustered based on their similarities. A representative for each cluster was assigned. To enhance sensitivity, we proposed an extended step that allows overlapping among clusters. A validation benchmark of 6000 randomly selected protein sequences was used to query the clustered profiles. To evaluate the efficiency of our approach, speed and recall values were measured and compared with the sequential search approach. Using hierarchical, k-means, and connected component clustering techniques followed by the extended overlapping step, we obtained an average reduction in time of 41%, and an average recall of 96%. Our results demonstrate that representation of profile-HMMs using a clustering-based approach can significantly accelerate data retrieval from profile-HMM databases.

Nuclear Reactors and Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cason, D.L.; Hicks, S.C.

1992-01-01

This publication Nuclear Reactors and Technology (NRT) announces on a monthly basis the current worldwide information available from the open literature on nuclear reactors and technology, including all aspects of power reactors, components and accessories, fuel elements, control systems, and materials. This publication contains the abstracts of DOE reports, journal articles, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database during the past month. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency`s Energy Technology Data Exchange or government-to-government agreements. The digests inmore » NRT and other citations to information on nuclear reactors back to 1948 are available for online searching and retrieval on the Energy Science and Technology Database and Nuclear Science Abstracts (NSA) database. Current information, added daily to the Energy Science and Technology Database, is available to DOE and its contractors through the DOE Integrated Technical Information System. Customized profiles can be developed to provide current information to meet each user`s needs.« less

[Acceptance and rejection of vasectomy in rural males].

PubMed

García Moreno, Juan; Solano Sainos, Luis Miguel

2005-01-01

One problem in rural population is the gap between coverage of contraception and scant masculine participation, which could be due to lack of information of to other sociocultural factors. We investigated, in two stages, the characteristics or the profile of the sexual and reproductive behavior of males in an exploratory study by means of focus groups to determine their relevant motivations and characteristics and subsequently, a structured questionnaire to ascertain the magnitude of the factors explored. The population corresponded to zones of rural hospital medical services zones of medical services in seven ethnic groups of the Mexican Republic and included men who accepted and who rejected vasectomy. The profile of males who accepted vasectomy allowed to determine that there exist a unsatisfied demand for contraceptive protection and the desire of not having additional children; in addition, we found that the decision to accept vasectomy is determined to a greater extent for reasons different from that of information on the contraceptive method. The important proportion of males who were non-users of contraceptive methods who accepted vasectomy supposed information on contraception to be the most consistent reason; nonetheless, this information was not considered sufficient and timely; thus, adverse economic situation, a certain condition related with the couple such as health or love for the female partner are the more weighty reasons for deciding to accept vasectomy, while the fear of poor sexual performance is the most powerful factor for rejection of vasectomy. Masculine participation in family planning is a factor that conditions contraceptive coverage and its respective benefits. The profile of the male who accepts vasectomy aids in identifying candidates forthe procedure and in reducing unsatisfied demand. Greater diffusion of information of the contraceptive method of vasectomy, greater links between male needs and vasectomy, and maintaining or increasing access to family planning are required.

Medicine Based Evidence for Individualized Decision Making: Case Study of Systemic Lupus Erythematosus.

PubMed

Wivel, Ashley E; Lapane, Kate; Kleoudis, Christi; Singer, Burton H; Horwitz, Ralph I

2017-11-01

To guide management decisions for an index patient, evidence is required from comparisons between approximate matches to the profile of the index case, where some matches contain responses to treatment and others act as controls. We describe a method for constructing clinically relevant histories/profiles using data collected but unreported from 2 recent phase 3 randomized controlled trials assessing belimumab in subjects with clinically active and serologically positive systemic lupus erythematosus. Outcome was the Systemic lupus erythematosus Responder Index (SRI) measured at 52 weeks. Among 1175 subjects, we constructed an algorithm utilizing 11 trajectory variables including 4 biological, 2 clinical, and 5 social/behavioral. Across all biological and social/behavioral variables, the proportion of responders based on the SRI whose value indicated clinical worsening or no improvement ranged from 27.5% to 42.3%. Kappa values suggested poor agreement, indicating that each biological and patient-reported outcome provides different information than gleaned from the SRI. The richly detailed patient profiles needed to guide decision-making in clinical practice are sharply at odds with the limited information utilized in conventional randomized controlled trial analyses. Copyright © 2017 Elsevier Inc. All rights reserved.

User and Content Characteristics of Public Tweets Referencing Little Cigars.

PubMed

Step, Mary M; Bracken, Cheryl C; Trapl, Erika S; Flocke, Susan A

2016-01-01

Compared to cigarettes, little cigars and cigarillos (LCC) are minimally regulated, affordable, and widely available to young people. Because Twitter is a preferred mode of communication among younger people, product portrayals may be useful for informing both interventions and public health or tobacco policy. A mixed-methods study was implemented to analyze the content of public tweets (N = 288) and profile photos sampled from a search of 2 LCC brands (Black & Mild and Swisher Sweets). Metadata and manifest attributes of profile photo demographic features and tweet message features were coded and analyzed. Thematic analysis of the tweets was conducted using an iterative immersion/ crystallization method. Tweeters were most often boys or men (63%) and appeared young (76%). Prevalent content themes included expressing affiliation for the LCC product and reporting smoking activity. Although men and women tweeted affiliation for LCC products and reported smoking activity in similar numbers, women were significantly less likely to tweet about blunting than men. Twitter provides a potentially potent source of nuanced information about how young people are using little cigars. These observed characteristics may be useful to inform counter-messaging strategies and interventions.

Latent Profiles of Perceived Time Adequacy for Paid Work, Parenting, and Partner Roles

PubMed Central

Lee, Soomi; Almeida, David M.; Davis, Kelly D.; King, Rosalind B.; Hammer, Leslie B.; Kelly, Erin L.

2015-01-01

This study examined feelings of having enough time (i.e., perceived time adequacy) in a sample of employed parents (N=880) in information technology and extended-care industries. Adapting a person-centered latent profile approach, we identified three profiles of perceived time adequacy for paid work, parenting, and partner roles: Family Time Protected, Family Time Sacrificed, and Time Balanced. Drawing upon the Conservation of Resources theory (Hobfòll, 1989), we examined the associations of stressors and resources with the time adequacy profiles. Parents in the Family Time Sacrificed profile were more likely to be younger, women, have younger children, work in the extended-care industry, and have nonstandard work schedules compared to those in the Family Time Protected profile. Results from multinomial logistic regression analyses revealed that, with the Time Balanced profile as the reference group, having fewer stressors and more resources in the family context (less parent-child conflict and more partner support), work context (longer company tenure, higher schedule control and job satisfaction), and work-family interface (lower work-to-family conflict) was linked to a higher probability of membership in the Family Time Protected profile. By contrast, having more stressors and fewer resources, in the forms of less partner support and higher work-to-family conflict, predicted a higher likelihood of being in the Family Time Sacrificed profile. Our findings suggest that low work-to-family conflict is the most critical predictor of membership in the Family Time Protected profile, whereas lack of partner support is the most important factor to be included in the Family Time Sacrificed profile. PMID:26075739

Profiles of traveler information services, update 2007.

DOT National Transportation Integrated Search

2007-07-01

Profiles of 511 Traveler Information Services Update 2007 was prepared by the Federal Transit Administrations (FTA) Office of Research, Demonstration and Innovation to increase public awareness, access, and knowledge of the transit content within ...

Information Security: A Scientometric Study of the Profile, Structure, and Dynamics of an Emerging Scholarly Specialty

ERIC Educational Resources Information Center

Olijnyk, Nicholas Victor

2014-01-01

The central aim of the current research is to explore and describe the profile, dynamics, and structure of the information security specialty. This study's objectives are guided by four research questions: 1. What are the salient features of information security as a specialty? 2. How has the information security specialty emerged and evolved from…

Reasoning about geography.

PubMed

Friedman, A; Brown, N R

2000-06-01

To understand the nature and etiology of biases in geographical judgments, the authors asked people to estimate latitudes (Experiments 1 and 2) and longitudes (Experiments 3 and 4) of cities throughout the Old and New Worlds. They also examined how people's biased geographical judgments change after they receive accurate information ("seeds") about actual locations. Location profiles constructed from the pre- and postseeding location estimates conveyed detailed information about the representations underlying geography knowledge, including the subjective positioning and subregionalization of regions within continents; differential seeding effects revealed between-region dependencies. The findings implicate an important role for conceptual knowledge and plausible-reasoning processes in tasks that use subjective geographical information.

Paleohydrological Information from Profiles in Pore Water of Holocene Low-Permeability Cores and Groundwater Flow Simulation, Lake Kasumigaura, Japan

NASA Astrophysics Data System (ADS)

Takamoto, N.; Shimada, J.

2014-12-01

The paleohydrological information can become important to predict hydrological conditions in the future. In Japan, which hydrologically is characterized by relatively small catchment scales with steep relief of topography under humid temperate climatic conditions, the residence time of the groundwater should be relatively short. Thus the paleohydrological information preserved in the groundwater aquifer should also be limited compared with the continental aquifer. However, regarding groundwater in clay and silt sediments have low-permeability characteristic, archiving the paleohydrologic information at the time of deposition is expected. 　Therefore, in this study, cores were drilled into Holocene clay and silt deposits (Site K-1 and Site K-2) in the Lake Kasumigaurain Japan, where the depositional rate 10,000 years ago was rapid and it has been affected strongly by sea level changes including transgression and regression. By using the obtained core samples and extracted pore water from the cores, paleohydrologic information was investigated, and it was tried to understand hydrologic environments at the study area during a Holocene. In addition, groundwater flow and solute transport simulation were conducted to reproduce profiles of pore water. 　Results of investigation show that the profiles of pore water contents reflect sea level change and the difference in hydrological environment at that time at each site. The content of the paleo-brackish water in the culmination of transgression was about 14,000 mg/l in Cl-, -13.0‰ in δD and -2.6‰ in δ18O. It is allowed better understanding paleohydrological information by studying not only inorganic chemistry contents and stable isotopes of pore water and also the diatom fossils and groundwater flow and solute transport simulation. We will characterize the paleohydrological information of the study area acquired by those investigations and analysis.

Analysis of floods, including the tropical storm Irene inundation, of the Ottauquechee River in Woodstock, Bridgewater, and Killington and of Reservoir Brook in Bridgewater and Plymouth, Vermont

USGS Publications Warehouse

Flynn, Robert H.

2014-01-01

In addition to the two digital flood inundation maps, flood profiles were created that depict the study reach flood elevation of tropical storm Irene of August 2011 and the 10-, 2-, 1-, and 0.2-percent AEP floods, also known as the 10-, 50-, 100-, and 500-year floods, respectively. The 10-, 2-, 1-, and 0.2-percent AEP flood discharges were determined using annual peak flow data from the USGS Ottauquechee River near West Bridgewater, Vt. streamgage (station 01150900). Flood profiles were computed for the Ottauquechee River and Reservoir Brook by means of a one-dimensional step-backwater model. The model was calibrated using documented high-water marks of the peak of the tropical storm Irene flood of August 2011 as well as stage discharge data as determined for USGS Ottauquechee River near West Bridgewater, Vt. streamgage (station 01150900). The simulated water-surface profiles were combined with a digital elevation model within a geographic information system to delineate the areas flooded during tropical storm Irene and for the 1-percent AEP water-surface profile. The digital elevation model data were derived from light detection and ranging (lidar) data obtained for a 3,281-foot (1,000-meter) corridor along the Ottauquechee River study reach and were augmented with 33-foot (10- meter) contour interval data in the modeled flood-inundation areas outside the lidar corridor. The 33-foot (10-meter) contour interval USGS 15-minute quadrangle topographic digital raster graphics map used to augment lidar data was produced at a scale of 1:24,000. The digital flood inundation maps and flood profiles along with information regarding current stage from USGS streamgages on the Internet provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

Low-flow profiles of the upper Oconee River and tributaries in Georgia

USGS Publications Warehouse

Carter, R.F.; Hopkins, E.H.; Perlman, H.A.

1988-01-01

Low flow information is provided for use in an evaluation of the capacity of streams to permit withdrawals or to accept waste loads without exceeding the limits of State water quality standards. The purpose of this report is to present the results of a compilation of available low flow data in the form of tables and ' 7Q10 flow profiles ' (minimum average flow for 7 consecutive days with a 10-yr recurrence interval)(7Q10 flow plotted against distance along a stream channel) for all streams reaches of the Upper Oconee River and tributaries in Georgia where sufficient data of acceptable accuracy are available. Drainage area profiles are included for all stream basins larger than 5 sq mi, except for those in a few remote areas. This report is the second in a series of reports that will cover all stream basins north of the Fall Line in Georgia. It includes the Oconee River basin down to and including Camp Creek at stream mile 134.53, Town Creek in Baldwin and Hancock Counties down to County Road 213-141, and Buffalo Creek in Hancock County down to the Hancock-Washington County line. Flow records were not adjusted for diversions or other factors that cause measured flows to represent other than natural flow conditions. The 7-day minimum flow profile was omitted for stream reaches where natural flow was known to be altered significantly. (Lantz-PTT)

Characterisation of ground motion recording stations in the Groningen gas field

NASA Astrophysics Data System (ADS)

Noorlandt, Rik; Kruiver, Pauline P.; de Kleine, Marco P. E.; Karaoulis, Marios; de Lange, Ger; Di Matteo, Antonio; von Ketelhodt, Julius; Ruigrok, Elmer; Edwards, Benjamin; Rodriguez-Marek, Adrian; Bommer, Julian J.; van Elk, Jan; Doornhof, Dirk

2018-05-01

The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity ( V S). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging. The offset SCPT, cross-hole tomography and common midpoint cross-correlation (CMPcc) processing of MASW data all revealed lateral variations on length scales of several to tens of metres in this geological setting. SCPTs resulted in very detailed V S profiles with depth, but represent point measurements in a heterogeneous environment. The MASW results represent V S information on a larger spatial scale and smooth some of the heterogeneity encountered at the sites. The combination of MASW and SCPT proved to be a powerful and cost-effective approach in determining representative V S profiles at the accelerograph station sites. The measured V S profiles correspond well with the modelled profiles and they significantly enhance the ground motion model derivation. The similarity between the theoretical transfer function from the V S profile and the observed amplification from vertical array stations is also excellent.

Characterisation of ground motion recording stations in the Groningen gas field

NASA Astrophysics Data System (ADS)

Noorlandt, Rik; Kruiver, Pauline P.; de Kleine, Marco P. E.; Karaoulis, Marios; de Lange, Ger; Di Matteo, Antonio; von Ketelhodt, Julius; Ruigrok, Elmer; Edwards, Benjamin; Rodriguez-Marek, Adrian; Bommer, Julian J.; van Elk, Jan; Doornhof, Dirk

2018-01-01

The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity (V S). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging. The offset SCPT, cross-hole tomography and common midpoint cross-correlation (CMPcc) processing of MASW data all revealed lateral variations on length scales of several to tens of metres in this geological setting. SCPTs resulted in very detailed V S profiles with depth, but represent point measurements in a heterogeneous environment. The MASW results represent V S information on a larger spatial scale and smooth some of the heterogeneity encountered at the sites. The combination of MASW and SCPT proved to be a powerful and cost-effective approach in determining representative V S profiles at the accelerograph station sites. The measured V S profiles correspond well with the modelled profiles and they significantly enhance the ground motion model derivation. The similarity between the theoretical transfer function from the V S profile and the observed amplification from vertical array stations is also excellent.

Propulsion and Power Technologies for the NASA Exploration Vision: A Research Perspective

NASA Technical Reports Server (NTRS)

Litchford, Ron J.

2004-01-01

Future propulsion and power technologies for deep space missions are profiled in this viewgraph presentation. The presentation includes diagrams illustrating possible future travel times to other planets in the solar system. The propulsion technologies researched at Marshall Space Flight Center (MSFC) include: 1) Chemical Propulsion; 2) Nuclear Propulsion; 3) Electric and Plasma Propulsion; 4) Energetics. The presentation contains additional information about these technologies, as well as space reactors, reactor simulation, and the Propulsion Research Laboratory (PRL) at MSFC.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepard, Bradley B.

The appendices include: (1) stream habitat inventory procedures; (2) lengths and volumes across hydroacoustic transects in Libby Reservoir; (3) temperature, pH, dissolved oxygen, and conductivity profiles in Libby Reservoir; (4) habitat survey information by reach; (5) gill net catches by species; (6) annual catches of fish in floating gill nets; (7) vertical distributions of fish and zooplankton; (8) timing of juvenile and adult movement through traps; (9) food habits information for collected fish; (10) estimated densities and composition of zooplankton by genera; (11) seasonal catch of macroinvertebrates; and (12) initial modeling effort on the Libby Reservoir fishery. (ACR)

Ice in space: An experimental and theoretical investigation

NASA Technical Reports Server (NTRS)

Patashnick, H.; Rupprecht, G.

1977-01-01

Basic knowledge is provided on the behavior of ice and ice particles under a wide variety of conditions including those of interplanetary space. This information and, in particular, the lifetime of ice particles as a function of solar distance is an absolute requirement for a proper interpretation of photometric profiles in comets. Because fundamental properties of ice and ice particles are developed in this report, the applicability of this information extends beyond the realm of comets into any area where volatile particles exist, be it in space or in the earth's atmosphere.

A Bayesian approach to microwave precipitation profile retrieval

NASA Technical Reports Server (NTRS)

Evans, K. Franklin; Turk, Joseph; Wong, Takmeng; Stephens, Graeme L.

1995-01-01

A multichannel passive microwave precipitation retrieval algorithm is developed. Bayes theorem is used to combine statistical information from numerical cloud models with forward radiative transfer modeling. A multivariate lognormal prior probability distribution contains the covariance information about hydrometeor distribution that resolves the nonuniqueness inherent in the inversion process. Hydrometeor profiles are retrieved by maximizing the posterior probability density for each vector of observations. The hydrometeor profile retrieval method is tested with data from the Advanced Microwave Precipitation Radiometer (10, 19, 37, and 85 GHz) of convection over ocean and land in Florida. The CP-2 multiparameter radar data are used to verify the retrieved profiles. The results show that the method can retrieve approximate hydrometeor profiles, with larger errors over land than water. There is considerably greater accuracy in the retrieval of integrated hydrometeor contents than of profiles. Many of the retrieval errors are traced to problems with the cloud model microphysical information, and future improvements to the algorithm are suggested.

Comment on the paper "Mars Express radio occultation data: A novel analysis approach" by Grandin et al. (2014)

NASA Astrophysics Data System (ADS)

Pätzold, M.; Bird, M. K.; Häusler, B.; Peter, K.; Tellmann, S.; Tyler, G. L.

2016-10-01

In their recent paper, Grandin et al. (2014) claim to have developed a novel approach, principally a ray tracing method, to analyze radio sounding data from occulted spacecraft signals by planetary atmospheres without the usual assumptions of the radio occultation inversion method of a stratified, layered, symmetric atmosphere. They apply their "new approach" to observations of the Mars Express Radio Science (MaRS) experiment and compare their resulting temperature, neutral number density, and electron density profiles with those from MaRS, claiming that there is good agreement with the observations. The fact is, however, that there are serious disagreements in the most important altitude ranges. Their temperature profile shows a 30 K shift or a 300σ (1σ standard deviation = 0.1 K for the MaRS profile near the surface) difference toward warmer temperatures at the surface when compared with MaRS, while the MaRS profile is in best agreement with the profile from the Mars Climate Data Base V5.0 (MCD V5.0). Their full temperature profile from the surface to 250 km altitude deviates significantly from the MCD V5.0 profile. Their ionospheric electron density profile is considerably different from that derived from the MaRs observations. Although Grandin et al. (2014) claim to derive the neutral number density and temperature profiles above 200 km, including the asymptotic exosphere temperature, it is simply not possible to derive this information from what is essentially noise.

Participant profiles according to recruitment source in a large Web-based prospective study: experience from the Nutrinet-Santé study.

PubMed

Kesse-Guyot, Emmanuelle; Andreeva, Valentina; Castetbon, Katia; Vernay, Michel; Touvier, Mathilde; Méjean, Caroline; Julia, Chantal; Galan, Pilar; Hercberg, Serge

2013-09-13

Interest in Internet-based epidemiologic research is growing given the logistic and cost advantages. Cohort recruitment to maximally diversify the sociodemographic profiles of participants, however, remains a contentious issue. The aim of the study was to characterize the sociodemographic profiles according to the recruitment mode of adult volunteers enrolled in a Web-based cohort. The French NutriNet-Santé Web-based cohort was launched in 2009. Recruitment is ongoing and largely relies on recurrent multimedia campaigns. One month after enrollment, participants are asked how they learned about the study (eg, general newscast or a health program on television, radio newscast, newspaper articles, Internet, personal advice, leaflet/flyers) The sociodemographic profiles of participants recruited through operative communication channels (radio, print media, Internet, advice) were compared with the profiles of those informed through television by using polytomous logistic regression. Among the 88,238 participants enrolled through the end of 2011, 30,401 (34.45%), 16,751 (18.98%), and 14,309 (16.22%) learned about the study from television, Internet, and radio newscasts, respectively. Sociodemographic profiles were various, with 14,541 (16.5%) aged ≥60 years, 20,166 (22.9%) aged <30 years, 27,766 (32.1%) without postsecondary education, 15,397 (19.7%) with household income <€1200/month, and 8258 (10.6%) with household income €3700/month. Compared to employed individuals, unemployed and retired participants were less likely to be informed about the study through other sources than through television (adjusted ORs 0.56-0.83, P<.001). Participants reporting up to secondary education were also less likely to have learned about the study through radio newscasts, newspaper articles, Internet, and advice than through television (adjusted ORs 0.60-0.77, P<.001). Television broadcasts appear to permit the recruitment of e-cohort participants with diverse sociodemographic backgrounds, including socioeconomically disadvantaged individuals who are usually difficult to reach and retain in long-term epidemiologic studies. These findings could inform future Web-based studies regarding the development of promising targeted or general population recruitment strategies.

Assimilation of Quality Controlled AIRS Temperature Profiles using the NCEP GFS

NASA Technical Reports Server (NTRS)

Susskind, Joel; Reale, Oreste; Iredell, Lena; Rosenberg, Robert

2013-01-01

We have previously conducted a number of data assimilation experiments using AIRS Version-5 quality controlled temperature profiles as a step toward finding an optimum balance of spatial coverage and sounding accuracy with regard to improving forecast skill. The data assimilation and forecast system we used was the Goddard Earth Observing System Model , Version-5 (GEOS-5) Data Assimilation System (DAS), which represents a combination of the NASA GEOS-5 forecast model with the National Centers for Environmental Prediction (NCEP) operational Grid Point Statistical Interpolation (GSI) global analysis scheme. All analyses and forecasts were run at a 0.5deg x 0.625deg spatial resolution. Data assimilation experiments were conducted in four different seasons, each in a different year. Three different sets of data assimilation experiments were run during each time period: Control; AIRS T(p); and AIRS Radiance. In the "Control" analysis, all the data used operationally by NCEP was assimilated, but no AIRS data was assimilated. Radiances from the Aqua AMSU-A instrument were also assimilated operationally by NCEP and are included in the "Control". The AIRS Radiance assimilation adds AIRS observed radiance observations for a select set of channels to the data set being assimilated, as done operationally by NCEP. In the AIRS T(p) assimilation, all information used in the Control was assimilated as well as Quality Controlled AIRS Version-5 temperature profiles, i.e., AIRS T(p) information was substituted for AIRS radiance information. The AIRS Version-5 temperature profiles were presented to the GSI analysis as rawinsonde profiles, assimilated down to a case-by-case appropriate pressure level p(sub best) determined using the Quality Control procedure. Version-5 also determines case-by-case, level-by-level error estimates of the temperature profiles, which were used as the uncertainty of each temperature measurement. These experiments using GEOS-5 have shown that forecasts resulting from analyses using the AIRS T(p) assimilation system were superior to those from the Radiance assimilation system, both with regard to global 7 day forecast skill and also the ability to predict storm tracks and intensity.

Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling.

PubMed

Tiss, Ali; Timms, John F; Smith, Celia; Devetyarov, Dmitry; Gentry-Maharaj, Aleksandra; Camuzeaux, Stephane; Burford, Brian; Nouretdinov, Ilia; Ford, Jeremy; Luo, Zhiyuan; Jacobs, Ian; Menon, Usha; Gammerman, Alex; Cramer, Rainer

2010-12-01

Our objective was to test the performance of CA125 in classifying serum samples from a cohort of malignant and benign ovarian cancers and age-matched healthy controls and to assess whether combining information from matrix-assisted laser desorption/ionization (MALDI) time-of-flight profiling could improve diagnostic performance. Serum samples from women with ovarian neoplasms and healthy volunteers were subjected to CA125 assay and MALDI time-of-flight mass spectrometry (MS) profiling. Models were built from training data sets using discriminatory MALDI MS peaks in combination with CA125 values and tested their ability to classify blinded test samples. These were compared with models using CA125 threshold levels from 193 patients with ovarian cancer, 290 with benign neoplasm, and 2236 postmenopausal healthy controls. Using a CA125 cutoff of 30 U/mL, an overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls, whereas a cutoff of 65 U/mL provided a sensitivity of 83.9% (99.6% specificity). High classification accuracies were obtained for early-stage cancers (93.5% sensitivity). Reasons for high accuracies include recruitment bias, restriction to postmenopausal women, and inclusion of only primary invasive epithelial ovarian cancer cases. The combination of MS profiling information with CA125 did not significantly improve the specificity/accuracy compared with classifications on the basis of CA125 alone. We report unexpectedly good performance of serum CA125 using threshold classification in discriminating healthy controls and women with benign masses from those with invasive ovarian cancer. This highlights the dependence of diagnostic tests on the characteristics of the study population and the crucial need for authors to provide sufficient relevant details to allow comparison. Our study also shows that MS profiling information adds little to diagnostic accuracy. This finding is in contrast with other reports and shows the limitations of serum MS profiling for biomarker discovery and as a diagnostic tool.

Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?

PubMed

Hu, Xindi C; Dassuncao, Clifton; Zhang, Xianming; Grandjean, Philippe; Weihe, Pál; Webster, Glenys M; Nielsen, Flemming; Sunderland, Elsie M

2018-02-01

Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects. We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases. Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure sources in two North American populations, suggesting generalizability of results from the Faroese population. We conclude that PFAS homologue profiles in serum provide valuable information on major exposure sources. It is essential to compare samples collected at similar time periods and to correct for demographic groups that are highly affected by differences in physiological processes (e.g., pregnancy). Information on PFAS homologue profiles is crucial for attributing adverse health effects to the proper mixtures or individual PFASs.

Transcriptome analysis and gene expression profiling of abortive and developing ovules during fruit development in hazelnut.

PubMed

Cheng, Yunqing; Liu, Jianfeng; Zhang, Huidi; Wang, Ju; Zhao, Yixin; Geng, Wanting

2015-01-01

A high ratio of blank fruit in hazelnut (Corylus heterophylla Fisch) is a very common phenomenon that causes serious yield losses in northeast China. The development of blank fruit in the Corylus genus is known to be associated with embryo abortion. However, little is known about the molecular mechanisms responsible for embryo abortion during the nut development stage. Genomic information for C. heterophylla Fisch is not available; therefore, data related to transcriptome and gene expression profiling of developing and abortive ovules are needed. In this study, de novo transcriptome sequencing and RNA-seq analysis were conducted using short-read sequencing technology (Illumina HiSeq 2000). The results of the transcriptome assembly analysis revealed genetic information that was associated with the fruit development stage. Two digital gene expression libraries were constructed, one for a full (normally developing) ovule and one for an empty (abortive) ovule. Transcriptome sequencing and assembly results revealed 55,353 unigenes, including 18,751 clusters and 36,602 singletons. These results were annotated using the public databases NR, NT, Swiss-Prot, KEGG, COG, and GO. Using digital gene expression profiling, gene expression differences in developing and abortive ovules were identified. A total of 1,637 and 715 unigenes were significantly upregulated and downregulated, respectively, in abortive ovules, compared with developing ovules. Quantitative real-time polymerase chain reaction analysis was used in order to verify the differential expression of some genes. The transcriptome and digital gene expression profiling data of normally developing and abortive ovules in hazelnut provide exhaustive information that will improve our understanding of the molecular mechanisms of abortive ovule formation in hazelnut.

Metabolomic Profiling of Prostate Cancer Progression During Active Surveillance

DTIC Science & Technology

2016-10-01

reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215...aggressive disease. 10. Payment and Remuneration a. Detail compensation for participants including possible total compensation, proposed bonus, and any...proposed reductions or penalties for not completing the protocol. Participants did not receive payment or remuneration for their original donation of

Metabolomic Profiling of Prostate Cancer Progression During Active Surveillance

DTIC Science & Technology

2015-10-01

reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215...Payment and Remuneration a. Detail compensation for participants including possible total compensation, proposed bonus, and any proposed reductions...or penalties for not completing the protocol. Participants did not receive payment or remuneration for their original donation of specimens or consent

A Case Study of Struggle and Success: Profiling a Third Grader's Reading and Writing in a Multimodal Curriculum

ERIC Educational Resources Information Center

Wiseman, Angela M.; Pendleton, Melissa; Christiansen, Christine; Nesheim, Nicole

2017-01-01

This article reports findings on a case study of Ellie as she participates in a language arts curriculum that incorporates multimodal literacy practices--including photography, drama, and art--to teach reading and writing. Our study was informed by the theoretical framework of multimodal social semiotics, which provides insight into how…

Understanding How School Vouchers Are Funded: Summary of Funding for Arizona's Empowerment Scholarship Accounts. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Stewart, Molly S.; Moon, Jodi S.

2016-01-01

This profile provides detailed local context for Arizona as part of Follow the "Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of enrollment and…

Understanding How School Vouchers Are Funded: Summary of Funding for the Louisiana Scholarship Program. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Stewart, Molly S.; Moon, Jodi S.

2016-01-01

This profile provides detailed local context for Louisiana as part of "Follow the Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of enrollment and…

HIE sustainability secrets. NeHC report shares HIE success stories of alternate revenue streams and payer buy-in.

PubMed

Prestigiacomo, Jennifer

2011-11-01

Getting effective stakeholder engagement, including that of payers, and creating innovative value-added services that provide alternate revenue streams beyond basic subscription services, are just a couple of the common traits of the flourishing health information exchanges profiled in the sustainability report released in August by the National eHealth Collaborative.

Topography of aortic heart valves. [applied to the development of a prosthetic heart valve

NASA Technical Reports Server (NTRS)

Karara, H. M.

1974-01-01

The cooperative effort towards the development of a tri-leaflet prosthetic heart valve is described. The photogrammetric studies were conducted on silicone rubber molds. Information on data acquisition and data reduction phases is given, and certain accuracy aspects of the project are explained. The various outputs which are discussed include digital models, profiles, and contour maps.

America's Changing Work Force: Statistics in Brief.

ERIC Educational Resources Information Center

American Association of Retired Persons, Washington, DC.

This booklet provides information about the demographics of the changing work force. It offers an at-a-glance profile of workers age 45 and older and considers likely changes in the work force of the future. The document includes topics such as the composition of the work force of today and tomorrow by age and sex, labor force participation rates,…

Does Differential Visual Exploration Contribute to Visual Memory Impairments in 22Q11.2 Microdeletion Syndrome?

ERIC Educational Resources Information Center

Bostelmann, M.; Glaser, B.; Zaharia, A.; Eliez, S.; Schneider, M.

2017-01-01

Background: Chromosome 22q11.2 microdeletion syndrome (22q11.2DS) is a genetic syndrome characterised by a unique cognitive profile. Individuals with the syndrome present several non-verbal deficits, including visual memory impairments and atypical exploration of visual information. In this study, we seek to understand how visual attention may…

New American Undergraduates: Enrollment Trends and Age at Arrival of Immigrant and Second-Generation Students. Stats in Brief. NCES 2017-414

ERIC Educational Resources Information Center

Arbeit, Caren A.; Staklis, Sandra; Horn, Laura

2016-01-01

Statistics in Brief publications present descriptive data in tabular formats to provide useful information to a broad audience, including members of the general public. They address simple and topical issues and questions. This Statistics in Brief profiles the demographic and enrollment characteristics of undergraduates who are immigrants or…

Systems genetics: a paradigm to improve discovery of candidate genes and mechanisms underlying complex traits.

PubMed

Feltus, F Alex

2014-06-01

Understanding the control of any trait optimally requires the detection of causal genes, gene interaction, and mechanism of action to discover and model the biochemical pathways underlying the expressed phenotype. Functional genomics techniques, including RNA expression profiling via microarray and high-throughput DNA sequencing, allow for the precise genome localization of biological information. Powerful genetic approaches, including quantitative trait locus (QTL) and genome-wide association study mapping, link phenotype with genome positions, yet genetics is less precise in localizing the relevant mechanistic information encoded in DNA. The coupling of salient functional genomic signals with genetically mapped positions is an appealing approach to discover meaningful gene-phenotype relationships. Techniques used to define this genetic-genomic convergence comprise the field of systems genetics. This short review will address an application of systems genetics where RNA profiles are associated with genetically mapped genome positions of individual genes (eQTL mapping) or as gene sets (co-expression network modules). Both approaches can be applied for knowledge independent selection of candidate genes (and possible control mechanisms) underlying complex traits where multiple, likely unlinked, genomic regions might control specific complex traits. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

CCProf: exploring conformational change profile of proteins

PubMed Central

Chang, Che-Wei; Chou, Chai-Wei; Chang, Darby Tien-Hao

2016-01-01

In many biological processes, proteins have important interactions with various molecules such as proteins, ions or ligands. Many proteins undergo conformational changes upon these interactions, where regions with large conformational changes are critical to the interactions. This work presents the CCProf platform, which provides conformational changes of entire proteins, named conformational change profile (CCP) in the context. CCProf aims to be a platform where users can study potential causes of novel conformational changes. It provides 10 biological features, including conformational change, potential binding target site, secondary structure, conservation, disorder propensity, hydropathy propensity, sequence domain, structural domain, phosphorylation site and catalytic site. All these information are integrated into a well-aligned view, so that researchers can capture important relevance between different biological features visually. The CCProf contains 986 187 protein structure pairs for 3123 proteins. In addition, CCProf provides a 3D view in which users can see the protein structures before and after conformational changes as well as binding targets that induce conformational changes. All information (e.g. CCP, binding targets and protein structures) shown in CCProf, including intermediate data are available for download to expedite further analyses. Database URL: http://zoro.ee.ncku.edu.tw/ccprof/ PMID:27016699

Chemical Data Assimilation: A Case Study of Solar Occultation Data From the Atlas 1 Mission of the Atmospheric Trace Molecule Spectroscopy Experiment

NASA Technical Reports Server (NTRS)

Lary, D. J.; Khattatov, B.; Mussa, H.

2003-01-01

A key advantage of using data assimilation is the propagation of information from data-rich regions to data-poor regions, which is particularly relevant to the use of solar occultation data such as from ATMOS. For the first time an in depth uncertainty analyses is included in a photochemical model-data intercomparison including observation, representativeness, and theoretical uncertainty. Chemical data assimilation of solar occultation measurements can be used to reconstruct full diurnal cycles and to evaluate their chemical self-consistency. This paper considers as an example the measurements made by the Atmospheric Trace Molecule Spectroscopy Experiment (ATMOS) instrument Atlas-1 during March 1992 for a vertical profile flow tracking coordinates at an equivalent PV latitude of 38 S. ATMOS was chosen because it simultaneously observes several species. This equivalent PV latitude was chosen as it was where ATMOS n observed the atmosphere's composition over the largest range of altitudes. A single vertical profile was used so that the detailed diurnal information that assimilation utilizes could be highlighted. There is generally good self-consistency between the ATMOS Atlas-1 observations and photochemical theory.

Advantages of soft versus hard constraints in self-modeling curve resolution problems. Alternating least squares with penalty functions.

PubMed

Gemperline, Paul J; Cash, Eric

2003-08-15

A new algorithm for self-modeling curve resolution (SMCR) that yields improved results by incorporating soft constraints is described. The method uses least squares penalty functions to implement constraints in an alternating least squares algorithm, including nonnegativity, unimodality, equality, and closure constraints. By using least squares penalty functions, soft constraints are formulated rather than hard constraints. Significant benefits are (obtained using soft constraints, especially in the form of fewer distortions due to noise in resolved profiles. Soft equality constraints can also be used to introduce incomplete or partial reference information into SMCR solutions. Four different examples demonstrating application of the new method are presented, including resolution of overlapped HPLC-DAD peaks, flow injection analysis data, and batch reaction data measured by UV/visible and near-infrared spectroscopy (NIR). Each example was selected to show one aspect of the significant advantages of soft constraints over traditionally used hard constraints. Incomplete or partial reference information into self-modeling curve resolution models is described. The method offers a substantial improvement in the ability to resolve time-dependent concentration profiles from mixture spectra recorded as a function of time.

Joint time/frequency-domain inversion of reflection data for seabed geoacoustic profiles and uncertainties.

PubMed

Dettmer, Jan; Dosso, Stan E; Holland, Charles W

2008-03-01

This paper develops a joint time/frequency-domain inversion for high-resolution single-bounce reflection data, with the potential to resolve fine-scale profiles of sediment velocity, density, and attenuation over small seafloor footprints (approximately 100 m). The approach utilizes sequential Bayesian inversion of time- and frequency-domain reflection data, employing ray-tracing inversion for reflection travel times and a layer-packet stripping method for spherical-wave reflection-coefficient inversion. Posterior credibility intervals from the travel-time inversion are passed on as prior information to the reflection-coefficient inversion. Within the reflection-coefficient inversion, parameter information is passed from one layer packet inversion to the next in terms of marginal probability distributions rotated into principal components, providing an efficient approach to (partially) account for multi-dimensional parameter correlations with one-dimensional, numerical distributions. Quantitative geoacoustic parameter uncertainties are provided by a nonlinear Gibbs sampling approach employing full data error covariance estimation (including nonstationary effects) and accounting for possible biases in travel-time picks. Posterior examination of data residuals shows the importance of including data covariance estimates in the inversion. The joint inversion is applied to data collected on the Malta Plateau during the SCARAB98 experiment.

ARMOUR - A Rice miRNA: mRNA Interaction Resource.

PubMed

Sanan-Mishra, Neeti; Tripathi, Anita; Goswami, Kavita; Shukla, Rohit N; Vasudevan, Madavan; Goswami, Hitesh

2018-01-01

ARMOUR was developed as A Rice miRNA:mRNA interaction resource. This informative and interactive database includes the experimentally validated expression profiles of miRNAs under different developmental and abiotic stress conditions across seven Indian rice cultivars. This comprehensive database covers 689 known and 1664 predicted novel miRNAs and their expression profiles in more than 38 different tissues or conditions along with their predicted/known target transcripts. The understanding of miRNA:mRNA interactome in regulation of functional cellular machinery is supported by the sequence information of the mature and hairpin structures. ARMOUR provides flexibility to users in querying the database using multiple ways like known gene identifiers, gene ontology identifiers, KEGG identifiers and also allows on the fly fold change analysis and sequence search query with inbuilt BLAST algorithm. ARMOUR database provides a cohesive platform for novel and mature miRNAs and their expression in different experimental conditions and allows searching for their interacting mRNA targets, GO annotation and their involvement in various biological pathways. The ARMOUR database includes a provision for adding more experimental data from users, with an aim to develop it as a platform for sharing and comparing experimental data contributed by research groups working on rice.

Profiles of 511 traveler information services update 2008.

DOT National Transportation Integrated Search

2008-07-01

Profiles of 511 Traveler Information Services Update 2008 was prepared by the Federal Transit : Administrations (FTA) Office of Research, Demonstration and Innovation to increase public : awareness, access, and knowledge of the transit content wit...

Profiles of 511 traveler information services update 2009.

DOT National Transportation Integrated Search

2009-04-01

Profiles of 511 Traveler Information Services Update 2009 was prepared by the Federal Transit Administrations (FTA) Office of Research, Demonstration and Innovation to increase public awareness, access, and knowledge of the transit content within ...

Enhanced semantic interoperability by profiling health informatics standards.

PubMed

López, Diego M; Blobel, Bernd

2009-01-01

Several standards applied to the healthcare domain support semantic interoperability. These standards are far from being completely adopted in health information system development, however. The objective of this paper is to provide a method and suggest the necessary tooling for reusing standard health information models, by that way supporting the development of semantically interoperable systems and components. The approach is based on the definition of UML Profiles. UML profiling is a formal modeling mechanism to specialize reference meta-models in such a way that it is possible to adapt those meta-models to specific platforms or domains. A health information model can be considered as such a meta-model. The first step of the introduced method identifies the standard health information models and tasks in the software development process in which healthcare information models can be reused. Then, the selected information model is formalized as a UML Profile. That Profile is finally applied to system models, annotating them with the semantics of the information model. The approach is supported on Eclipse-based UML modeling tools. The method is integrated into a comprehensive framework for health information systems development, and the feasibility of the approach is demonstrated in the analysis, design, and implementation of a public health surveillance system, reusing HL7 RIM and DIMs specifications. The paper describes a method and the necessary tooling for reusing standard healthcare information models. UML offers several advantages such as tooling support, graphical notation, exchangeability, extensibility, semi-automatic code generation, etc. The approach presented is also applicable for harmonizing different standard specifications.

Understanding the online health information user profiles in Korea: from a psychological perspective.

PubMed

Shin, Sung Hee; Yun, Eun Kyoung

2011-06-01

This study was conducted to explore the profiles of online health information users in terms of certain psychological characteristics and to suggest guidelines for the provision of better user-oriented health information service. The cross-sectional study design was used with convenient sampling by Web-based questionnaire survey in Korea. To analyze health information user profiles on the Internet, a two-step cluster analysis was conducted. The results reveal that online health information users can be classified into four groups according to their level of subjective knowledge and health concern. The findings also suggest that four clusters that exhibit distinct profile patterns exist. The findings of this study would be useful for health portal developers who would like to understand users' characteristics and behaviors and to provide more user-oriented service in a satisfactory manner. It is suggested that to develop a full understanding of users' behaviors regarding Internet health information service, further research would be needed to explore users' various needs, their preferences, and relevant factors among users across a variety of health problem-addressing Web sites at different professional levels.

Application of constrained deconvolution technique for reconstruction of electron bunch profile with strongly non-Gaussian shape

NASA Astrophysics Data System (ADS)

Geloni, G.; Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

2004-08-01

An effective and practical technique based on the detection of the coherent synchrotron radiation (CSR) spectrum can be used to characterize the profile function of ultra-short bunches. The CSR spectrum measurement has an important limitation: no spectral phase information is available, and the complete profile function cannot be obtained in general. In this paper we propose to use constrained deconvolution method for bunch profile reconstruction based on a priori-known information about formation of the electron bunch. Application of the method is illustrated with practically important example of a bunch formed in a single bunch-compressor. Downstream of the bunch compressor the bunch charge distribution is strongly non-Gaussian with a narrow leading peak and a long tail. The longitudinal bunch distribution is derived by measuring the bunch tail constant with a streak camera and by using a priory available information about profile function.

Quantitative Analysis of Gender Stereotypes and Information Aggregation in a National Election

PubMed Central

Tumminello, Michele; Miccichè, Salvatore; Varho, Jan; Piilo, Jyrki; Mantegna, Rosario N.

2013-01-01

By analyzing a database of a questionnaire answered by a large majority of candidates and elected in a parliamentary election, we quantitatively verify that (i) female candidates on average present political profiles which are more compassionate and more concerned with social welfare issues than male candidates and (ii) the voting procedure acts as a process of information aggregation. Our results show that information aggregation proceeds with at least two distinct paths. In the first case candidates characterize themselves with a political profile aiming to describe the profile of the majority of voters. This is typically the case of candidates of political parties which are competing for the center of the various political dimensions. In the second case, candidates choose a political profile manifesting a clear difference from opposite political profiles endorsed by candidates of a political party positioned at the opposite extreme of some political dimension. PMID:23555606

Fracture Network Characteristics Informed by Detailed Studies of Chlorinated Solvent Plumes in Sedimentary Rock Aquifers

NASA Astrophysics Data System (ADS)

Parker, B. L.; Chapman, S.

2015-12-01

Various numerical approaches have been used to simulate contaminant plumes in fractured porous rock, but the one that allows field and laboratory measurements to be most directly used as inputs to these models is the Discrete Fracture Network (DFN) Approach. To effectively account for fracture-matrix interactions, emphasis must be placed on identifying and parameterizing all of the fractures that participate substantially in groundwater flow and contaminated transport. High resolution plume studies at four primary research sites, where chlorinated solvent plumes serve as long-term (several decades) tracer tests, provide insight concerning the density of the fracture network unattainable by conventional methods. Datasets include contaminant profiles from detailed VOC subsampling informed by continuous core logs, hydraulic head and transmissivity profiles, packer testing and sensitive temperature logging methods in FLUTe™ lined holes. These show presence of many more transmissive fractures, contrasting observations of only a few flow zones per borehole obtained from conventional hydraulic tests including flow metering in open boreholes. Incorporating many more fractures with a wider range of transmissivities is key to predicting contaminant migration. This new understanding of dense fracture networks combined with matrix property measurements have informed 2-D DFN flow and transport modelling using Fractran and HydroGeosphere to simulate plume characteristics ground-truthed by detailed field site plume characterization. These process-based simulations corroborate field findings that plumes in sedimentary rock after decades of transport show limited plume front distances and strong internal plume attenuation by diffusion, transverse dispersion and slow degradation. This successful application of DFN modeling informed by field-derived parameters demonstrates how the DFN Approach can be applied to other sites to inform plume migration rates and remedial efficacy.

The male of the species: a profile of men in nursing.

PubMed

Stanley, David; Beament, Tania; Falconer, Darren; Haigh, Margaret; Saunders, Rosemary; Stanley, Karen; Wall, Peter; Nielson, Sharon

2016-05-01

To establish a profile of men in nursing in Western Australia and explore the perception of men in nursing from the perspective of male and female nurses. A project team, including some of the current authors, produced a YouTube video and DVD about men in nursing which led to further enquiry on this topic. The study employed a non-experimental, comparative, descriptive research design focused on a quantitative methodology, using an online survey in early 2014. A convenience sample incorporated registered and enrolled nurses and midwives in Western Australia. The range of data included demographic information and the respondents' perceptions of men in nursing were collected. Findings indicated that the main reasons for choosing a career in nursing or midwifery were similar for both genders. Common mis-perceptions of men in nursing included: most male nurses are gay; men are not suited to nursing and men are less caring and compassionate than women. Suggestions to promote nursing to men included: nurses are highly skilled professionals; there is the potential to make a difference for patients; nursing offers stable employment, professional diversity and opportunities for team work. There is a diminished awareness of opportunities for men in nursing and negative stereotypes related to men in nursing persist. The study produced recommendations which included: using the right message to target the recruitment for men and promoting a more realistic understanding of the profile and perception of men in nursing. © 2016 John Wiley & Sons Ltd.

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

PubMed Central

Miyagi, Yohei; Higashiyama, Masahiko; Gochi, Akira; Akaike, Makoto; Ishikawa, Takashi; Miura, Takeshi; Saruki, Nobuhiro; Bando, Etsuro; Kimura, Hideki; Imamura, Fumio; Moriyama, Masatoshi; Ikeda, Ichiro; Chiba, Akihiko; Oshita, Fumihiro; Imaizumi, Akira; Yamamoto, Hiroshi; Miyano, Hiroshi; Horimoto, Katsuhisa; Tochikubo, Osamu; Mitsushima, Toru; Yamakado, Minoru; Okamoto, Naoyuki

2011-01-01

Background Recently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs) is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases, including cancers. Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection. Methods and Findings Plasma samples were collected from approximately 200 patients from multiple institutes, each diagnosed with one of the following five types of cancer: lung, gastric, colorectal, breast, or prostate cancer. Patients were compared to gender- and age- matched controls also used in this study. The PFAA levels were measured using high-performance liquid chromatography (HPLC)–electrospray ionization (ESI)–mass spectrometry (MS). Univariate analysis revealed significant differences in the PFAA profiles between the controls and the patients with any of the five types of cancer listed above, even those with asymptomatic early-stage disease. Furthermore, multivariate analysis clearly discriminated the cancer patients from the controls in terms of the area under the receiver-operator characteristics curve (AUC of ROC >0.75 for each cancer), regardless of cancer stage. Because this study was designed as case-control study, further investigations, including model construction and validation using cohorts with larger sample sizes, are necessary to determine the usefulness of PFAA profiling. Conclusions These findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a relatively simple plasma assay and imposes a lower physical burden on subjects when compared to existing screening methods. PMID:21915291

Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory.

PubMed

Haberman, Rebecca P; Colantuoni, Carlo; Koh, Ming Teng; Gallagher, Michela

2013-01-01

Aging is often associated with cognitive decline, but many elderly individuals maintain a high level of function throughout life. Here we studied outbred rats, which also exhibit individual differences across a spectrum of outcomes that includes both preserved and impaired spatial memory. Previous work in this model identified the CA3 subfield of the hippocampus as a region critically affected by age and integral to differing cognitive outcomes. Earlier microarray profiling revealed distinct gene expression profiles in the CA3 region, under basal conditions, for aged rats with intact memory and those with impairment. Because prominent age-related deficits within the CA3 occur during neural encoding of new information, here we used microarray analysis to gain a broad perspective of the aged CA3 transcriptome under activated conditions. Behaviorally-induced CA3 expression profiles differentiated aged rats with intact memory from those with impaired memory. In the activated profile, we observed substantial numbers of genes (greater than 1000) exhibiting increased expression in aged unimpaired rats relative to aged impaired, including many involved in synaptic plasticity and memory mechanisms. This unimpaired aged profile also overlapped significantly with a learning induced gene profile previously acquired in young adults. Alongside the increased transcripts common to both young learning and aged rats with preserved memory, many transcripts behaviorally-activated in the current study had previously been identified as repressed in the aged unimpaired phenotype in basal expression. A further distinct feature of the activated profile of aged rats with intact memory is the increased expression of an ensemble of genes involved in inhibitory synapse function, which could control the phenotype of neural hyperexcitability found in the CA3 region of aged impaired rats. These data support the conclusion that aged subjects with preserved memory recruit adaptive mechanisms to retain tight control over excitability under both basal and activated conditions.

The Human Cell Atlas.

PubMed

Regev, Aviv; Teichmann, Sarah A; Lander, Eric S; Amit, Ido; Benoist, Christophe; Birney, Ewan; Bodenmiller, Bernd; Campbell, Peter; Carninci, Piero; Clatworthy, Menna; Clevers, Hans; Deplancke, Bart; Dunham, Ian; Eberwine, James; Eils, Roland; Enard, Wolfgang; Farmer, Andrew; Fugger, Lars; Göttgens, Berthold; Hacohen, Nir; Haniffa, Muzlifah; Hemberg, Martin; Kim, Seung; Klenerman, Paul; Kriegstein, Arnold; Lein, Ed; Linnarsson, Sten; Lundberg, Emma; Lundeberg, Joakim; Majumder, Partha; Marioni, John C; Merad, Miriam; Mhlanga, Musa; Nawijn, Martijn; Netea, Mihai; Nolan, Garry; Pe'er, Dana; Phillipakis, Anthony; Ponting, Chris P; Quake, Stephen; Reik, Wolf; Rozenblatt-Rosen, Orit; Sanes, Joshua; Satija, Rahul; Schumacher, Ton N; Shalek, Alex; Shapiro, Ehud; Sharma, Padmanee; Shin, Jay W; Stegle, Oliver; Stratton, Michael; Stubbington, Michael J T; Theis, Fabian J; Uhlen, Matthias; van Oudenaarden, Alexander; Wagner, Allon; Watt, Fiona; Weissman, Jonathan; Wold, Barbara; Xavier, Ramnik; Yosef, Nir

2017-12-05

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Description and evaluation of the Acoustic Profiling of Ocean Currents (APOC) system used on R. V. Oceanus cruise 96 on 11-22 May 1981

NASA Technical Reports Server (NTRS)

Joyce, T. M.; Rintoul, S. R., Jr.; Barbour, R. L.

1982-01-01

The underway current profiling system which consists of a microprocessor controlled data logger that collects and formats data from a four beam Ametek-Straza 300 kHz acoustic Doppler current profiler, heading from the ship's gyrocompass, and navigation information from a Loran-C receiver and a satellite navigation unit is discussed. Data are recorded on magnetic tape and real time is calculated. Time averaging is required to remove effects of ship motion. An intercomparison is made with a moored vector measuring current meter (VMCM). The mean difference in hourly averaged APOC and VMCM currents over the four hour intercomparison is a few mm s minus including: two Gulf Stream crossings, a warm core ring survey, and shallow water in a frontal zone to the east of Nantucket Shoals.

The Human Cell Atlas

PubMed Central

Amit, Ido; Benoist, Christophe; Birney, Ewan; Bodenmiller, Bernd; Campbell, Peter; Carninci, Piero; Clatworthy, Menna; Clevers, Hans; Deplancke, Bart; Dunham, Ian; Eberwine, James; Eils, Roland; Enard, Wolfgang; Farmer, Andrew; Fugger, Lars; Göttgens, Berthold; Hacohen, Nir; Haniffa, Muzlifah; Hemberg, Martin; Kim, Seung; Klenerman, Paul; Kriegstein, Arnold; Lein, Ed; Linnarsson, Sten; Lundberg, Emma; Lundeberg, Joakim; Majumder, Partha; Marioni, John C; Merad, Miriam; Mhlanga, Musa; Nawijn, Martijn; Netea, Mihai; Nolan, Garry; Pe'er, Dana; Phillipakis, Anthony; Ponting, Chris P; Quake, Stephen; Reik, Wolf; Rozenblatt-Rosen, Orit; Sanes, Joshua; Satija, Rahul; Schumacher, Ton N; Shalek, Alex; Shapiro, Ehud; Sharma, Padmanee; Shin, Jay W; Stegle, Oliver; Stratton, Michael; Stubbington, Michael J T; Theis, Fabian J; Uhlen, Matthias; van Oudenaarden, Alexander; Wagner, Allon; Watt, Fiona; Weissman, Jonathan; Wold, Barbara; Xavier, Ramnik; Yosef, Nir

2017-01-01

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community. PMID:29206104

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

PubMed Central

Liang, Winnie S.; Dunckley, Travis; Beach, Thomas G.; Grover, Andrew; Mastroeni, Diego; Walker, Douglas G.; Caselli, Richard J.; Kukull, Walter A.; McKeel, Daniel; Morris, John C.; Hulette, Christine; Schmechel, Donald; Alexander, Gene E.; Reiman, Eric M.; Rogers, Joseph; Stephan, Dietrich A.

2008-01-01

In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer’s disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders. PMID:17077275

Standards to support information systems integration in anatomic pathology.

PubMed

Daniel, Christel; García Rojo, Marcial; Bourquard, Karima; Henin, Dominique; Schrader, Thomas; Della Mea, Vincenzo; Gilbertson, John; Beckwith, Bruce A

2009-11-01

Integrating anatomic pathology information- text and images-into electronic health care records is a key challenge for enhancing clinical information exchange between anatomic pathologists and clinicians. The aim of the Integrating the Healthcare Enterprise (IHE) international initiative is precisely to ensure interoperability of clinical information systems by using existing widespread industry standards such as Digital Imaging and Communication in Medicine (DICOM) and Health Level Seven (HL7). To define standard-based informatics transactions to integrate anatomic pathology information to the Healthcare Enterprise. We used the methodology of the IHE initiative. Working groups from IHE, HL7, and DICOM, with special interest in anatomic pathology, defined consensual technical solutions to provide end-users with improved access to consistent information across multiple information systems. The IHE anatomic pathology technical framework describes a first integration profile, "Anatomic Pathology Workflow," dedicated to the diagnostic process including basic image acquisition and reporting solutions. This integration profile relies on 10 transactions based on HL7 or DICOM standards. A common specimen model was defined to consistently identify and describe specimens in both HL7 and DICOM transactions. The IHE anatomic pathology working group has defined standard-based informatics transactions to support the basic diagnostic workflow in anatomic pathology laboratories. In further stages, the technical framework will be completed to manage whole-slide images and semantically rich structured reports in the diagnostic workflow and to integrate systems used for patient care and those used for research activities (such as tissue bank databases or tissue microarrayers).

Integrating the healthcare enterprise in radiation oncology plug and play--the future of radiation oncology?

PubMed

Abdel-Wahab, May; Rengan, Ramesh; Curran, Bruce; Swerdloff, Stuart; Miettinen, Mika; Field, Colin; Ranjitkar, Sunita; Palta, Jatinder; Tripuraneni, Prabhakar

2010-02-01

To describe the processes and benefits of the integrating healthcare enterprises in radiation oncology (IHE-RO). The IHE-RO process includes five basic steps. The first step is to identify common interoperability issues encountered in radiation treatment planning and the delivery process. IHE-RO committees partner with vendors to develop solutions (integration profiles) to interoperability problems. The broad application of these integration profiles across a variety of vender platforms is tested annually at the Connectathon event. Demonstration of the seamless integration and transfer of patient data to the potential users are then presented by vendors at the public demonstration event. Users can then integrate these profiles into requests for proposals and vendor contracts by institutions. Incorporation of completed integration profiles into requests for proposals can be done when purchasing new equipment. Vendors can publish IHE integration statements to document the integration profiles supported by their products. As a result, users can reference integration profiles in requests for proposals, simplifying the systems acquisition process. These IHE-RO solutions are now available in many of the commercial radiation oncology-related treatment planning, delivery, and information systems. They are also implemented at cancer care sites around the world. IHE-RO serves an important purpose for the radiation oncology community at large. Copyright 2010 Elsevier Inc. All rights reserved.

Sonic-boom ground-pressure measurements from Apollo 15

NASA Technical Reports Server (NTRS)

Hilton, D. A.; Henderson, H. R.; Mckinney, R.

1972-01-01

Sonic boom pressure signatures recorded during the launch and reentry phases of the Apollo 15 mission are presented. The measurements were obtained along the vehicle ground track at 87 km and 970 km downrange from the launch site during ascent; and at 500 km, 55.6 km, and 12.9 km from the splashdown point during reentry. Tracings of the measured signatures are included along with values of the overpressure, impulse, time duration, and rise times. Also included are brief descriptions of the launch and recovery test areas in which the measurements were obtained, the sonic boom instrumentation deployment, flight profiles and operating conditions for the launch vehicle and spacecraft, surface weather information at the measuring sites, and high altitude weather information for the general measurement areas.

Residential Mobility and Lung Cancer Risk: Data-Driven Exploration Using Internet Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Hong-Jun; Tourassi, Georgia; Xu, Songhua

2015-01-01

Frequent relocation has been linked to health decline, particularly with respect to emotional and psychological wellbeing. In this paper we investigate whether there is an association between frequent relocation and lung cancer risk. For the initial investigation we leverage two online data sources to collect cancer and control subjects using web crawling and tailored text mining. The two data sources share different strengths and weaknesses in terms of the amount of detail, population representation, and sample size. One data source includes online obituaries. The second data source includes augmented LinkedIn profiles. For each data source, the subjects spatiotemporal history ismore » reconstructed from the available information provided in the obituaries and from the education and work experience provided in the LinkedIn profiles. The study shows that lung cancer subjects have higher mobility frequency than the control group. This trend is consistent for both data sources.« less

The Profile of Creativity and Proposing Statistical Problem Quality Level Reviewed From Cognitive Style

NASA Astrophysics Data System (ADS)

Awi; Ahmar, A. S.; Rahman, A.; Minggi, I.; Mulbar, U.; Asdar; Ruslan; Upu, H.; Alimuddin; Hamda; Rosidah; Sutamrin; Tiro, M. A.; Rusli

2018-01-01

This research aims to reveal the profile about the level of creativity and the ability to propose statistical problem of students at Mathematics Education 2014 Batch in the State University of Makassar in terms of their cognitive style. This research uses explorative qualitative method by giving meta-cognitive scaffolding at the time of research. The hypothesis of research is that students who have field independent (FI) cognitive style in statistics problem posing from the provided information already able to propose the statistical problem that can be solved and create new data and the problem is already been included as a high quality statistical problem, while students who have dependent cognitive field (FD) commonly are still limited in statistics problem posing that can be finished and do not load new data and the problem is included as medium quality statistical problem.

Digital Presence of Norwegian Scholars on Academic Network Sites—Where and Who Are They?

PubMed Central

Gjesdal, Øyvind Liland; Al Ruwehy, Hemed Ali

2015-01-01

The use of academic profiling sites is becoming more common, and emerging technologies boost researchers’ visibility and exchange of ideas. In our study we compared profiles at five different profiling sites. These five sites are ResearchGate, Academia.edu, Google Scholar Citations, ResearcherID and ORCID. The data set is enriched by demographic information including age, gender, position and affiliation, which are provided by the national CRIS-system in Norway. We find that approximately 37% of researchers at the University of Bergen have at least one profile, the prevalence being highest (> 40%) for members at the Faculty of Psychology and the Faculty of Social Sciences. Across all disciplines, ResearchGate is the most widely used platform. However, within Faculty of Humanities, Academia.edu is the preferred one. Researchers are reluctant to maintain multiple profiles, and there is little overlap between different services. Age turns out to be a poor indicator for presence in the investigated profiling sites, women are underrepresented and professors together with PhD students are the most likely profile holders. We next investigated the correlation between bibliometric measures, such as publications and citations, and user activities, such as downloads and followers. We find different bibliometric indicators to correlate strongly within individual platforms and across platforms. There is however less agreement between the traditional bibliometric and social activity indicators. PMID:26565408

Profiles of 511 traveler information services : nationwide deployment areas : draft copy

DOT National Transportation Integrated Search

2006-04-01

Profiles of 511 Traveler Information Services was prepared by the Federal Transit Administration's (FTA) Office of Research, Demonstration and Innovation to increase public awareness, access, and knowledge of the transit content within existing 511 t...

Molecular profiling of advanced breast cancer tumors is beneficial in assisting clinical treatment plans.

PubMed

Carter, Philip; Alifrangis, Costi; Cereser, Biancastella; Chandrasinghe, Pramodh; Del Bel Belluz, Lisa; Moderau, Nina; Poyia, Fotini; Schwartzberg, Lee S; Tabassum, Neha; Wen, Jinrui; Krell, Jonathan; Stebbing, Justin

2018-04-03

We used data obtained by Caris Life Sciences, to evaluate the benefits of tailoring treatments for a breast carcinoma cohort by using tumor molecular profiles to inform decisions. Data for 92 breast cancer patients from the commercial Caris Molecular Intelligence database was retrospectively divided into two groups, so that the first always followed treatment recommendations, whereas in the second group all patients received at least one drug after profiling that was predicted to lack benefit. The biomarker and drug associations were based on tests including fluorescent in situ hybridization and DNA sequencing, although immunohistochemistry was the main test used. Patients whose drugs matched those recommended according to their tumor profile had an average overall survival of 667 days, compared to 510 days for patients that did not (P=0.0316). In the matched treatment group, 26% of patients were deceased by the last time of monitoring, whereas this was 41% in the unmatched group (P=0.1257). We therefore confirm the ability of tumor molecular profiling to improve survival of breast cancer patients. Immunohistochemistry biomarkers for the androgen, estrogen and progesterone receptors were found to be prognostic for survival.

Effective Filtering of Query Results on Updated User Behavioral Profiles in Web Mining

PubMed Central

Sadesh, S.; Suganthe, R. C.

2015-01-01

Web with tremendous volume of information retrieves result for user related queries. With the rapid growth of web page recommendation, results retrieved based on data mining techniques did not offer higher performance filtering rate because relationships between user profile and queries were not analyzed in an extensive manner. At the same time, existing user profile based prediction in web data mining is not exhaustive in producing personalized result rate. To improve the query result rate on dynamics of user behavior over time, Hamilton Filtered Regime Switching User Query Probability (HFRS-UQP) framework is proposed. HFRS-UQP framework is split into two processes, where filtering and switching are carried out. The data mining based filtering in our research work uses the Hamilton Filtering framework to filter user result based on personalized information on automatic updated profiles through search engine. Maximized result is fetched, that is, filtered out with respect to user behavior profiles. The switching performs accurate filtering updated profiles using regime switching. The updating in profile change (i.e., switches) regime in HFRS-UQP framework identifies the second- and higher-order association of query result on the updated profiles. Experiment is conducted on factors such as personalized information search retrieval rate, filtering efficiency, and precision ratio. PMID:26221626

Health information systems and pesticide poisoning at Pernambuco.

PubMed

de Albuquerque, Pedro Costa Cavalcanti; Gurgel, Idê Gomes Dantas; Gurgel, Aline do Monte; Augusto, Lia Giraldo da Silva; de Siqueira, Marília Teixeira

2015-01-01

Understanding the epidemiologic profile of a particular disease is key to undertake health actions. To that end, information systems that present quality data help in the decision-making process and demonstrate the impact of the problems. To analyze the contribution of health information systems for the characterization of pesticide poisoning through SINAN, CEATOX and SIM in the State of Pernambuco. In this study, the completeness and consistency of the data were assessed, as well as the epidemiological profile of pesticide poisoning in Pernambuco in the period from 2008 to 2012, based on the following Health Information Systems: Center for Toxicological Assistance of Pernambuco (CEATOX), Notifiable Diseases Information System (SINAN) and Mortality Information System (SIM). The data revealed incompleteness and inconsistencies in information. Regarding the profile, females are more affected in the morbidity profile, and men have a higher mortality rate. Poisoning was more frequent in young adults with low educational level. With regard to the circumstances, most of the cases were suicide attempts, unique acute cases and not related to work. Despite suggesting underreporting, the data showed that persons engaged in agriculture are most commonly affected. The strengthening of these systems is necessary for the generation of consistent information that support health policies for the population groups involved.

Identification of epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG3''Me) and amino acid profiles in various tea (Camellia sinensis L.) cultivars.

PubMed

Ji, Hyang-Gi; Lee, Yeong-Ran; Lee, Min-Seuk; Hwang, Kyeng Hwan; Kim, Eun-Hee; Park, Jun Seong; Hong, Young-Shick

2017-10-01

This article includes experimental data on the identification of epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG3''Me) by 2-dimensional (2D) proton ( 1 H) NMR analysis and on the information of amino acid and catechin compound profiles by HPLC analysis in leaf extracts of various tea cultivars. These data are related to the research article " Metabolic phenotyping of various tea (Camellia sinensis L.) cultivars and understanding of their intrinsic metabolism " (Ji et al., 2017) [1]. The assignment for EGCG3x''Me by 1 H NMR analysis was also confirmed with spiking experiment of its pure chemical.

Divided by a Common Degree Program? Profiling Online and Face-to-Face Information Science Students

ERIC Educational Resources Information Center

Haigh, Maria

2007-01-01

This study examines profiles of online and face-to-face students in a single information science school: the University of Wisconsin-Milwaukee School of Information Studies. A questionnaire was administered to 76 students enrolled in online course sections and 72 students enrolled in face-to-face course sections. The questionnaire examined student…

An Information Needs Profile of Israeli Older Adults, regarding the Law and Services

ERIC Educational Resources Information Center

Getz, Irith; Weissman, Gabriella

2010-01-01

Based on Nicholas' framework for assessing information needs, this research aims to construct a profile of both Israeli older adults and their information needs regarding laws and social services. Data were collected by questionnaires answered by 200 older adults, born in Europe, Asia and Africa, who attended social clubs for older adults. The…

Latent profiles of perceived time adequacy for paid work, parenting, and partner roles.

PubMed

Lee, Soomi; Almeida, David M; Davis, Kelly D; King, Rosalind B; Hammer, Leslie B; Kelly, Erin L

2015-10-01

This study examined feelings of having enough time (i.e., perceived time adequacy) in a sample of employed parents (N = 880) in information technology and extended-care industries. Adapting a person-centered latent profile approach, we identified 3 profiles of perceived time adequacy for paid work, parenting, and partner roles: family time protected, family time sacrificed, and time balanced. Drawing upon the conservation of resources theory (Hobfòll, 1989), we examined the associations of stressors and resources with the time adequacy profiles. Parents in the family time sacrificed profile were more likely to be younger, women, have younger children, work in the extended-care industry, and have nonstandard work schedules compared to those in the family time protected profile. Results from multinomial logistic regression analyses revealed that, with the time balanced profile as the reference group, having fewer stressors and more resources in the family context (less parent-child conflict and more partner support), work context (longer company tenure, higher schedule control and job satisfaction), and work-family interface (lower work-to-family conflict) was linked to a higher probability of membership in the family time protected profile. By contrast, having more stressors and fewer resources, in the forms of less partner support and higher work-to-family conflict, predicted a higher likelihood of being in the family time sacrificed profile. Our findings suggest that low work-to-family conflict is the most critical predictor of membership in the family time protected profile, whereas lack of partner support is the most important factor to be included in the family time sacrificed profile. (c) 2015 APA, all rights reserved).

Recommendations for processing atmospheric attenuated backscatter profiles from Vaisala CL31 ceilometers

NASA Astrophysics Data System (ADS)

Kotthaus, Simone; O'Connor, Ewan; Münkel, Christoph; Charlton-Perez, Cristina; Haeffelin, Martial; Gabey, Andrew M.; Grimmond, C. Sue B.

2016-08-01

Ceilometer lidars are used for cloud base height detection, to probe aerosol layers in the atmosphere (e.g. detection of elevated layers of Saharan dust or volcanic ash), and to examine boundary layer dynamics. Sensor optics and acquisition algorithms can strongly influence the observed attenuated backscatter profiles; therefore, physical interpretation of the profiles requires careful application of corrections. This study addresses the widely deployed Vaisala CL31 ceilometer. Attenuated backscatter profiles are studied to evaluate the impact of both the hardware generation and firmware version. In response to this work and discussion within the CL31/TOPROF user community (TOPROF, European COST Action aiming to harmonise ground-based remote sensing networks across Europe), Vaisala released new firmware (versions 1.72 and 2.03) for the CL31 sensors. These firmware versions are tested against previous versions, showing that several artificial features introduced by the data processing have been removed. Hence, it is recommended to use this recent firmware for analysing attenuated backscatter profiles. To allow for consistent processing of historic data, correction procedures have been developed that account for artefacts detected in data collected with older firmware. Furthermore, a procedure is proposed to determine and account for the instrument-related background signal from electronic and optical components. This is necessary for using attenuated backscatter observations from any CL31 ceilometer. Recommendations are made for the processing of attenuated backscatter observed with Vaisala CL31 sensors, including the estimation of noise which is not provided in the standard CL31 output. After taking these aspects into account, attenuated backscatter profiles from Vaisala CL31 ceilometers are considered capable of providing valuable information for a range of applications including atmospheric boundary layer studies, detection of elevated aerosol layers, and model verification.

Meta-Analysis of Personality Traits in Alzheimer’s Disease: A Comparison with Healthy Subjects

PubMed Central

D’Iorio, Alfonsina; Garramone, Federica; Piscopo, Fausta; Baiano, Chiara; Raimo, Simona; Santangelo, Gabriella

2018-01-01

Background: The role of specific personality traits as factor risks of Alzheimer’s disease (AD) has been consistently found, whereas personality traits specifically related to AD (after the diagnosis) have not been outlined yet. Objective: A meta-analysis of published studies was performed to determine whether AD patients have a distinctive personality trait profile compared to healthy subjects (HC), similar to or different from a premorbid personality profile consistently reported in previous studies. Methods: A systematic literature search was performed using PsycInfo (PROQUEST), PubMed, and Scopus. The meta-analysis pooled results from primary studies using Hedges’ g unbiased approach. Results: The meta-analysis included 10 primary studies and revealed that, when the personality was evaluated by informant-rated measures, AD patients had significantly higher levels of Neuroticism, lower levels of Openness, Agreeableness, Conscientiousness, and Extraversion than HCs. When the personality was evaluated by self-rated measures, the results obtained from informants were confirmed for Neuroticism, Openness, and Extraversion but not for Agreeableness and Conscientiousness where AD patients and HCs achieved similar scores. Conclusions: The meta-analysis revealed that high Neuroticism and low Openness and Extraversion are distinctive personality traits significantly associated with a diagnosis of AD when evaluated both self-rated and informant-rated measures. This personality trait profile is similar to premorbid one, which contributes to development of AD over time. Therefore, our findings indirectly support the idea of specific premorbid personality traits as harbingers of AD. PMID:29480186

Exploring Game Performance in the National Basketball Association Using Player Tracking Data

PubMed Central

Calleja-González, Julio; Jiménez Sáiz, Sergio; Schelling i del Alcázar, Xavi; Balciunas, Mindaugas

2015-01-01

Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i) compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA), and (ii) describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230). The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams. PMID:26171606

Exploring Game Performance in the National Basketball Association Using Player Tracking Data.

PubMed

Sampaio, Jaime; McGarry, Tim; Calleja-González, Julio; Jiménez Sáiz, Sergio; Schelling I Del Alcázar, Xavi; Balciunas, Mindaugas

2015-01-01

Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i) compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA), and (ii) describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230). The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams.

Modulatory Effects of Modafinil on Neural Circuits Regulating Emotion and Cognition

PubMed Central

Rasetti, Roberta; Mattay, Venkata S; Stankevich, Beth; Skjei, Kelsey; Blasi, Giuseppe; Sambataro, Fabio; Arrillaga-Romany, Isabel C; Goldberg, Terry E; Callicott, Joseph H; Apud, José A; Weinberger, Daniel R

2010-01-01

Modafinil differs from other arousal-enhancing agents in chemical structure, neurochemical profile, and behavioral effects. Most functional neuroimaging studies to date examined the effect of modafinil only on information processing underlying executive cognition, but cognitive enhancers in general have been shown to have pronounced effects on emotional behavior, too. We examined the effect of modafinil on neural circuits underlying affective processing and cognitive functions. Healthy volunteers were enrolled in this double-blinded placebo-controlled trial (100 mg/day for 7 days). They underwent BOLD fMRI while performing an emotion information-processing task that activates the amygdala and two prefrontally dependent cognitive tasks—a working memory (WM) task and a variable attentional control (VAC) task. A clinical assessment that included measurement of blood pressure, heart rate, the Hamilton anxiety scale, and the profile of mood state (POMS) questionnaire was also performed on each test day. BOLD fMRI revealed significantly decreased amygdala reactivity to fearful stimuli on modafinil compared with the placebo condition. During executive cognition tasks, a WM task and a VAC task, modafinil reduced BOLD signal in the prefrontal cortex and anterior cingulate. Although not statistically significant, there were trends for reduced anxiety, for decreased fatigue-inertia and increased vigor-activity, as well as decreased anger-hostility on modafinil. Modafinil in low doses has a unique physiologic profile compared with stimulant drugs: it enhances the efficiency of prefrontal cortical cognitive information processing, while dampening reactivity to threatening stimuli in the amygdala, a brain region implicated in anxiety. PMID:20555311

Triangular Mesh Generation of Elevation Versus Distance Course Profiles for use with Road Property Files

DTIC Science & Technology

2010-09-01

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions...the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 1 . AGENCY USE ONLY (Leave blank) 2. REPORT DATE... 1 2.0 ROAD GEOMETRY CREATION ............................................................. 1 3.0 NODE AND ELEMENT CREATION

Social Circles Detection from Ego Network and Profile Information

DTIC Science & Technology

2014-12-19

response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing... algorithm used to infer k-clique communities is expo- nential, which makes this technique unfeasible when treating egonets with a large number of users...atic when considering RBMs. This inconvenient was positively solved implementing a sparsity treatment with the RBM algorithm . (ii) The ground truth was

Understanding How School Vouchers Are Funded: Summary of Funding for the District of Columbia's Opportunity Scholarship Program. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Moon, Jodi S.; Stewart, Molly S.

2016-01-01

This profile provides detailed local context for the District of Columbia as part of "Follow the Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of…

Understanding How School Vouchers Are Funded: Summary of Funding for the Indiana Choice Scholarship Program. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Moon, Jodi S.; Stewart, Molly S.

2016-01-01

This profile provides detailed local context for Indiana as part of "Follow the Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of enrollment and…

Understanding How School Vouchers Are Funded: Summary of Funding for Wisconsin's Three Parental Choice Programs. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Stewart, Molly S.; Moon, Jodi S.

2016-01-01

This profile provides detailed local context for Wisconsin as part of "Follow the Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of enrollment and…

Understanding How School Vouchers Are Funded: Summary of Funding for Ohio's Cleveland Scholarship and EdChoice Programs. Informing Policy & Improving Practice Research Brief

ERIC Educational Resources Information Center

Stewart, Molly S.; Moon, Jodi S.

2016-01-01

This profile provides detailed local context for Ohio as part of "Follow the Money: A Detailed Analysis of the Funding Mechanisms of Voucher Programs in Six Cases" (Arizona, the District of Columbia, Indiana, Louisiana, Ohio, and Wisconsin). This three-part report includes a cross-case review, data visualizations of enrollment and…

Applied Communication, Argumentation, and Debate: Abstracts of Doctoral Dissertations Published in "Dissertation Abstracts International," July through December 1985 (Vol. 46 Nos. 1 through 6).

ERIC Educational Resources Information Center

ERIC Clearinghouse on Reading and Communication Skills, Urbana, IL.

This collection of abstracts is part of a continuing series providing information on recent doctoral dissertations. The 21 titles deal with a variety of topics, including the following: (1) comparison of receiver profiles in Clark County, Nevada, for various school-community relations communications channels; (2) effects of profit knowledge, size…

Profile: the Philippine Population Information Network.

PubMed

1991-06-01

The profile of Philippine Population Information Network (POPIN) is described in this article as having changed management structure from the Population Center Foundation to the Government's Population Commission, Information Management and Research Division (IMRD) in 1989. This restructuring resulted in the transfer in 1990 of the Department of Social Welfare and Development to the Office of the President. POPIN also serves Asia/Pacific POPIN. POPCOM makes policy and coordinates and monitors population activities. POPIN's goal is to improve the flow and utilization of population information nationwide. The National Population Library was moved in 1989 to the POPCOM Central Office Building and became the Philippine Information Center. The collection includes 6000 books, 400 research reports, and 4000 other documents (brochures, reprints, conference materials, and so on); 42 video tapes about the Philippine population program and a cassette player are available. In 1989, 14 regional centers were set up in POPCOM regional offices and designated Regional Population Information Centers. There are also school-based information centers operating as satellite information centers. The Regional and school-based centers serve the purpose of providing technical information through collection development, cataloguing, classification, storage and retrieval, and circulation. The target users are policy makers, government and private research agencies, researchers, and faculty and students. Publications developed and produced by the Center include the 3rd Supplement of the Union Catalogue of Population Literature, the 1987-88 Annotated Bibliography of Philippine Population Literature (PPL), the forthcoming 1989-90 edition of the Annotated Bibliography of PPL, and a biyearly newsletter, POPINEWS. Microcomputers have been acquired for the Regional Centers, with the idea of computerizing POPIN. Computer upgrading is also being done within the IMRD to provide POPLINE CD--ROM capability. Central and regional staff have also had their skills upgraded; e.g., IMRD's staff in the use of Micro-ISIS software, which is used for developing databases and directories. Training is being conducted in the ESCAP database and directory grant program, and in information center management and desktop publishing. Linkages have been made with the local networks, which have contributed to the upgrading effort.

From loquacious to reticent: understanding patient health information communication to guide consumer health IT design.

PubMed

Valdez, Rupa S; Guterbock, Thomas M; Fitzgibbon, Kara; Williams, Ishan C; Wellbeloved-Stone, Claire A; Bears, Jaime E; Menefee, Hannah K

2017-07-01

It is increasingly recognized that some patients self-manage in the context of social networks rather than alone. Consumer health information technology (IT) designed to support socially embedded self-management must be responsive to patients' everyday communication practices. There is an opportunity to improve consumer health IT design by explicating how patients currently leverage social media to support health information communication. The objective of this study was to determine types of health information communication patterns that typify Facebook users with chronic health conditions to guide consumer health IT design. Seven hundred participants with type 2 diabetes were recruited through a commercial survey access panel. Cluster analysis was used to identify distinct approaches to health information communication both on and off Facebook. Analysis of variance (ANOVA) methods were used to identify demographic and behavioral differences among profiles. Secondary analysis of qualitative interviews ( n  = 25) and analysis of open-ended survey questions were conducted to understand participant rationales for each profile. Our analysis yielded 7 distinct health information communication profiles. Five of 7 profiles had consistent patterns both on and off Facebook, while the remaining 2 demonstrated distinct practices, with no health information communication on Facebook but some off Facebook. One profile was distinct from all others in both health information communication practices and demographic composition. Rationales for following specific health information communication practices were categorized under 6 themes: altruism, instrumental support, social support, privacy and stigma, convenience, and Facebook knowledge. Facebook has been widely adopted for health information communication; This study demonstrates that Facebook has been widely adopted for health information communication. It also shows that the ways in which patients communicate health information on and off Facebook are diverse. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A Prototype Physical Database for Passive Microwave Retrievals of Precipitation over the US Southern Great Plains

NASA Technical Reports Server (NTRS)

Ringerud, S.; Kummerow, C. D.; Peters-Lidard, C. D.

2015-01-01

An accurate understanding of the instantaneous, dynamic land surface emissivity is necessary for a physically based, multi-channel passive microwave precipitation retrieval scheme over land. In an effort to assess the feasibility of the physical approach for land surfaces, a semi-empirical emissivity model is applied for calculation of the surface component in a test area of the US Southern Great Plains. A physical emissivity model, using land surface model data as input, is used to calculate emissivity at the 10GHz frequency, combining contributions from the underlying soil and vegetation layers, including the dielectric and roughness effects of each medium. An empirical technique is then applied, based upon a robust set of observed channel covariances, extending the emissivity calculations to all channels. For calculation of the hydrometeor contribution, reflectivity profiles from the Tropical Rainfall Measurement Mission Precipitation Radar (TRMM PR) are utilized along with coincident brightness temperatures (Tbs) from the TRMM Microwave Imager (TMI), and cloud-resolving model profiles. Ice profiles are modified to be consistent with the higher frequency microwave Tbs. Resulting modeled top of the atmosphere Tbs show correlations to observations of 0.9, biases of 1K or less, root-mean-square errors on the order of 5K, and improved agreement over the use of climatological emissivity values. The synthesis of these models and data sets leads to the creation of a simple prototype Tb database that includes both dynamic surface and atmospheric information physically consistent with the land surface model, emissivity model, and atmospheric information.

Plasma metabolic profiling analysis of nephrotoxicity induced by acyclovir using metabonomics coupled with multivariate data analysis.

PubMed

Zhang, Xiuxiu; Li, Yubo; Zhou, Huifang; Fan, Simiao; Zhang, Zhenzhu; Wang, Lei; Zhang, Yanjun

2014-08-01

Acyclovir (ACV) is an antiviral agent. However, its use is limited by adverse side effect, particularly by its nephrotoxicity. Metabonomics technology can provide essential information on the metabolic profiles of biofluids and organs upon drug administration. Therefore, in this study, mass spectrometry-based metabonomics coupled with multivariate data analysis was used to identify the plasma metabolites and metabolic pathways related to nephrotoxicity caused by intraperitoneal injection of low (50mg/kg) and high (100mg/kg) doses of acyclovir. Sixteen biomarkers were identified by metabonomics and nephrotoxicity results revealed the dose-dependent effect of acyclovir on kidney tissues. The present study showed that the top four metabolic pathways interrupted by acyclovir included the metabolisms of arachidonic acid, tryptophan, arginine and proline, and glycerophospholipid. This research proves the established metabonomic approach can provide information on changes in metabolites and metabolic pathways, which can be applied to in-depth research on the mechanism of acyclovir-induced kidney injury. Copyright © 2014 Elsevier B.V. All rights reserved.

Generalized Cross Entropy Method for estimating joint distribution from incomplete information

NASA Astrophysics Data System (ADS)

Xu, Hai-Yan; Kuo, Shyh-Hao; Li, Guoqi; Legara, Erika Fille T.; Zhao, Daxuan; Monterola, Christopher P.

2016-07-01

Obtaining a full joint distribution from individual marginal distributions with incomplete information is a non-trivial task that continues to challenge researchers from various domains including economics, demography, and statistics. In this work, we develop a new methodology referred to as ;Generalized Cross Entropy Method; (GCEM) that is aimed at addressing the issue. The objective function is proposed to be a weighted sum of divergences between joint distributions and various references. We show that the solution of the GCEM is unique and global optimal. Furthermore, we illustrate the applicability and validity of the method by utilizing it to recover the joint distribution of a household profile of a given administrative region. In particular, we estimate the joint distribution of the household size, household dwelling type, and household home ownership in Singapore. Results show a high-accuracy estimation of the full joint distribution of the household profile under study. Finally, the impact of constraints and weight on the estimation of joint distribution is explored.

Integrative Analysis of Response to Tamoxifen Treatment in ER-Positive Breast Cancer Using GWAS Information and Transcription Profiling.

PubMed

Hicks, Chindo; Kumar, Ranjit; Pannuti, Antonio; Miele, Lucio

2012-01-01

Variable response and resistance to tamoxifen treatment in breast cancer patients remains a major clinical problem. To determine whether genes and biological pathways containing SNPs associated with risk for breast cancer are dysregulated in response to tamoxifen treatment, we performed analysis combining information from 43 genome-wide association studies with gene expression data from 298 ER(+) breast cancer patients treated with tamoxifen and 125 ER(+) controls. We identified 95 genes which distinguished tamoxifen treated patients from controls. Additionally, we identified 54 genes which stratified tamoxifen treated patients into two distinct groups. We identified biological pathways containing SNPs associated with risk for breast cancer, which were dysregulated in response to tamoxifen treatment. Key pathways identified included the apoptosis, P53, NFkB, DNA repair and cell cycle pathways. Combining GWAS with transcription profiling provides a unified approach for associating GWAS findings with response to drug treatment and identification of potential drug targets.

Introduction to the special issue on the personality assessment inventory.

PubMed

Kurtz, John E; Blais, Mark A

2007-02-01

This special issue of the Journal of Personality Assessment brings together 13 new research studies on the Personality Assessment Inventory (PAI; Morey, 1991) that should inform users and stimulate future empirical activity with this measure. In 4 articles, authors evaluate the validity scales and indexes of the PAI using both analog and criterion designs and samples from a variety of clinical and forensic settings. In a 5th article, the authors describe a novel approach to profile interpretation using two PAI negative distortion measures. The authors present applications of the PAI to new populations and problems including a German translation of the PAI and profile information for male batterers and victims of head injury. The authors of 2 studies extend research on the validity of the PAI for the assessment of borderline personality disorder. In the final 3 studies, the authors evaluate the validity of PAI measures of violence and aggression to predict subsequent aggressive behavior and institutional misconduct. Finally, the authors offer several suggestions for future research with the PAI.

Comprehensive RNA-Seq profiling to evaluate lactating sheep mammary gland transcriptome

PubMed Central

Suárez-Vega, Aroa; Gutiérrez-Gil, Beatriz; Klopp, Christophe; Tosser-Klopp, Gwenola; Arranz, Juan-José

2016-01-01

RNA-Seq enables the generation of extensive transcriptome information providing the capability to characterize transcripts (including alternative isoforms and polymorphism), to quantify expression and to identify differential regulation in a single experiment. Our aim in this study was to take advantage of using RNA-Seq high-throughput technology to provide a comprehensive transcriptome profiling of the sheep lactating mammary gland. Eight ewes of two dairy sheep breeds with differences in milk production traits were used in this experiment (four Churra and four Assaf ewes). Milk samples from these animals were collected on days 10, 50, 120 and 150 after lambing to cover the various physiological stages of the mammary gland across the complete lactation. RNA samples were extracted from milk somatic cells. The RNA-Seq dataset was generated using an Illumina HiSeq 2000 sequencer. The information reported here will be useful to understand the biology of lactation in sheep, providing also an opportunity to characterize their different patterns on milk production aptitude. PMID:27377755

CancerDR: cancer drug resistance database.

PubMed

Kumar, Rahul; Chaudhary, Kumardeep; Gupta, Sudheer; Singh, Harinder; Kumar, Shailesh; Gautam, Ankur; Kapoor, Pallavi; Raghava, Gajendra P S

2013-01-01

Cancer therapies are limited by the development of drug resistance, and mutations in drug targets is one of the main reasons for developing acquired resistance. The adequate knowledge of these mutations in drug targets would help to design effective personalized therapies. Keeping this in mind, we have developed a database "CancerDR", which provides information of 148 anti-cancer drugs, and their pharmacological profiling across 952 cancer cell lines. CancerDR provides comprehensive information about each drug target that includes; (i) sequence of natural variants, (ii) mutations, (iii) tertiary structure, and (iv) alignment profile of mutants/variants. A number of web-based tools have been integrated in CancerDR. This database will be very useful for identification of genetic alterations in genes encoding drug targets, and in turn the residues responsible for drug resistance. CancerDR allows user to identify promiscuous drug molecules that can kill wide range of cancer cells. CancerDR is freely accessible at http://crdd.osdd.net/raghava/cancerdr/

Comprehensive RNA-Seq profiling to evaluate lactating sheep mammary gland transcriptome.

PubMed

Suárez-Vega, Aroa; Gutiérrez-Gil, Beatriz; Klopp, Christophe; Tosser-Klopp, Gwenola; Arranz, Juan-José

2016-07-05

RNA-Seq enables the generation of extensive transcriptome information providing the capability to characterize transcripts (including alternative isoforms and polymorphism), to quantify expression and to identify differential regulation in a single experiment. Our aim in this study was to take advantage of using RNA-Seq high-throughput technology to provide a comprehensive transcriptome profiling of the sheep lactating mammary gland. Eight ewes of two dairy sheep breeds with differences in milk production traits were used in this experiment (four Churra and four Assaf ewes). Milk samples from these animals were collected on days 10, 50, 120 and 150 after lambing to cover the various physiological stages of the mammary gland across the complete lactation. RNA samples were extracted from milk somatic cells. The RNA-Seq dataset was generated using an Illumina HiSeq 2000 sequencer. The information reported here will be useful to understand the biology of lactation in sheep, providing also an opportunity to characterize their different patterns on milk production aptitude.

The Tropical Convective Spectrum. Part 1; Archetypal Vertical Structures

NASA Technical Reports Server (NTRS)

Boccippio, Dennis J.; Petersen, Walter A.; Cecil, Daniel J.

2005-01-01

A taxonomy of tropical convective and stratiform vertical structures is constructed through cluster analysis of 3 yr of Tropical Rainfall Measuring Mission (TRMM) "warm-season" (surface temperature greater than 10 C) precipitation radar (PR) vertical profiles, their surface rainfall, and associated radar-based classifiers (convective/ stratiform and brightband existence). Twenty-five archetypal profile types are identified, including nine convective types, eight stratiform types, two mixed types, and six anvil/fragment types (nonprecipitating anvils and sheared deep convective profiles). These profile types are then hierarchically clustered into 10 similar families, which can be further combined, providing an objective and physical reduction of the highly multivariate PR data space that retains vertical structure information. The taxonomy allows for description of any storm or local convective spectrum by the profile types or families. The analysis provides a quasi-independent corroboration of the TRMM 2A23 convective/ stratiform classification. The global frequency of occurrence and contribution to rainfall for the profile types are presented, demonstrating primary rainfall contribution by midlevel glaciated convection (27%) and similar depth decaying/stratiform stages (28%-31%). Profiles of these types exhibit similar 37- and 85-GHz passive microwave brightness temperatures but differ greatly in their frequency of occurrence and mean rain rates, underscoring the importance to passive microwave rain retrieval of convective/stratiform discrimination by other means, such as polarization or texture techniques, or incorporation of lightning observations. Close correspondence is found between deep convective profile frequency and annualized lightning production, and pixel-level lightning occurrence likelihood directly tracks the estimated mean ice water path within profile types.

MeRy-B: a web knowledgebase for the storage, visualization, analysis and annotation of plant NMR metabolomic profiles

PubMed Central

2011-01-01

Background Improvements in the techniques for metabolomics analyses and growing interest in metabolomic approaches are resulting in the generation of increasing numbers of metabolomic profiles. Platforms are required for profile management, as a function of experimental design, and for metabolite identification, to facilitate the mining of the corresponding data. Various databases have been created, including organism-specific knowledgebases and analytical technique-specific spectral databases. However, there is currently no platform meeting the requirements for both profile management and metabolite identification for nuclear magnetic resonance (NMR) experiments. Description MeRy-B, the first platform for plant 1H-NMR metabolomic profiles, is designed (i) to provide a knowledgebase of curated plant profiles and metabolites obtained by NMR, together with the corresponding experimental and analytical metadata, (ii) for queries and visualization of the data, (iii) to discriminate between profiles with spectrum visualization tools and statistical analysis, (iv) to facilitate compound identification. It contains lists of plant metabolites and unknown compounds, with information about experimental conditions, the factors studied and metabolite concentrations for several plant species, compiled from more than one thousand annotated NMR profiles for various organs or tissues. Conclusion MeRy-B manages all the data generated by NMR-based plant metabolomics experiments, from description of the biological source to identification of the metabolites and determinations of their concentrations. It is the first database allowing the display and overlay of NMR metabolomic profiles selected through queries on data or metadata. MeRy-B is available from http://www.cbib.u-bordeaux2.fr/MERYB/index.php. PMID:21668943

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.

PubMed

Frismantas, Viktoras; Dobay, Maria Pamela; Rinaldi, Anna; Tchinda, Joelle; Dunn, Samuel H; Kunz, Joachim; Richter-Pechanska, Paulina; Marovca, Blerim; Pail, Orrin; Jenni, Silvia; Diaz-Flores, Ernesto; Chang, Bill H; Brown, Timothy J; Collins, Robert H; Uhrig, Sebastian; Balasubramanian, Gnana P; Bandapalli, Obul R; Higi, Salome; Eugster, Sabrina; Voegeli, Pamela; Delorenzi, Mauro; Cario, Gunnar; Loh, Mignon L; Schrappe, Martin; Stanulla, Martin; Kulozik, Andreas E; Muckenthaler, Martina U; Saha, Vaskar; Irving, Julie A; Meisel, Roland; Radimerski, Thomas; Von Stackelberg, Arend; Eckert, Cornelia; Tyner, Jeffrey W; Horvath, Peter; Bornhauser, Beat C; Bourquin, Jean-Pierre

2017-03-16

Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblastic leukemia (ALL) samples mostly from resistant disease in cocultures of bone marrow stromal cells. Patient-derived xenografts retained the original pattern of mutations found in the matched patient material. Stromal coculture did not prevent leukemia cell cycle activity, but a specific sensitivity profile to cell cycle-related drugs identified samples with higher cell proliferation both in vitro and in vivo as leukemia xenografts. In patients with refractory relapses, individual patterns of marked drug resistance and exceptional responses to new agents of immediate clinical relevance were detected. The BCL2-inhibitor venetoclax was highly active below 10 nM in B-cell precursor ALL (BCP-ALL) subsets, including MLL -AF4 and TCF3-HLF ALL, and in some T-cell ALLs (T-ALLs), predicting in vivo activity as a single agent and in combination with dexamethasone and vincristine. Unexpected sensitivity to dasatinib with half maximal inhibitory concentration values below 20 nM was detected in 2 independent T-ALL cohorts, which correlated with similar cytotoxic activity of the SRC inhibitor KX2-391 and inhibition of SRC phosphorylation. A patient with refractory T-ALL was treated with dasatinib on the basis of drug profiling information and achieved a 5-month remission. Thus, drug profiling captures disease-relevant features and unexpected sensitivity to relevant drugs, which warrants further exploration of this functional assay in the context of clinical trials to develop drug repurposing strategies for patients with urgent medical needs. © 2017 by The American Society of Hematology.

Activity profile of high-level Australian lacrosse players.

PubMed

Polley, Chris S; Cormack, Stuart J; Gabbett, Tim J; Polglaze, Ted

2015-01-01

Despite lacrosse being one of the fastest growing team sports in the world, there is a paucity of information detailing the activity profile of high-level players. Microtechnology systems (global positioning systems and accelerometers) provide the opportunity to obtain detailed information on the activity profile in lacrosse. Therefore, this study aimed to analyze the activity profile of lacrosse match-play using microtechnology. Activity profile variables assessed relative to minutes of playing time included relative distance (meter per minute), distance spent standing (0-0.1 m·min), walking (0.2-1.7 m·min), jogging (1.8-3.2 m·min), running (3.3-5.6 m·min), sprinting (≥5.7 m·min), number of high, moderate, low accelerations and decelerations, and player load (PL per minute), calculated as the square root of the sum of the squared instantaneous rate of change in acceleration in 3 vectors (medio-lateral, anterior-posterior, and vertical). Activity was recorded from 14 lacrosse players over 4 matches during a national tournament. Players were separated into positions of attack, midfield, or defense. Differences (effect size [ES] ± 90% confidence interval) between positions and periods of play were considered likely positive when there was ≥75% likelihood of the difference exceeding an ES threshold of 0.2. Midfielders had likely covered higher (mean ± SD) meters per minute (100 ± 11) compared with attackers (87 ± 14; ES = 0.89 ± 1.04) and defenders (79 ± 14; ES = 1.54 ± 0.94) and more moderate and high accelerations and decelerations. Almost all variables across positions were reduced in quarter 4 compared with quarter 1. Coaches should accommodate for positional differences when preparing lacrosse players for competition.

Deep RNA-Seq profile reveals biodiversity, plant-microbe interactions and a large family of NBS-LRR resistance genes in walnut (Juglans regia) tissues.

PubMed

Chakraborty, Sandeep; Britton, Monica; Martínez-García, P J; Dandekar, Abhaya M

2016-03-01

Deep RNA-Seq profiling, a revolutionary method used for quantifying transcriptional levels, often includes non-specific transcripts from other co-existing organisms in spite of stringent protocols. Using the recently published walnut genome sequence as a filter, we present a broad analysis of the RNA-Seq derived transcriptome profiles obtained from twenty different tissues to extract the biodiversity and possible plant-microbe interactions in the walnut ecosystem in California. Since the residual nature of the transcripts being analyzed does not provide sufficient information to identify the exact strain, inferences made are constrained to the genus level. The presence of the pathogenic oomycete Phytophthora was detected in the root through the presence of a glyceraldehyde-3-phosphate dehydrogenase. Cryptococcus, the causal agent of cryptococcosis, was found in the catkins and vegetative buds, corroborating previous work indicating that the plant surface supported the sexual cycle of this human pathogen. The RNA-Seq profile revealed several species of the endophytic nitrogen fixing Actinobacteria. Another bacterial species implicated in aerobic biodegradation of methyl tert-butyl ether (Methylibium petroleiphilum) is also found in the root. RNA encoding proteins from the pea aphid were found in the leaves and vegetative buds, while a serine protease from mosquito with significant homology to a female reproductive tract protease from Drosophila mojavensis in the vegetative bud suggests egg-laying activities. The comprehensive analysis of RNA-seq data present also unraveled detailed, tissue-specific information of ~400 transcripts encoded by the largest family of resistance (R) genes (NBS-LRR), which possibly rationalizes the resistance of the specific walnut plant to the pathogens detected. Thus, we elucidate the biodiversity and possible plant-microbe interactions in several walnut (Juglans regia) tissues in California using deep RNA-Seq profiling.

Helping the public find information the U.S. Government Information Locator Service (GILS)

USGS Publications Warehouse

Christian, E.J.

1994-01-01

As part of the National Information Infrastructure, the U.S. federal government is establishing a Government Information Locator Service (GILS). GILS will identify and describe public information resources throughout the federal government and provide assistance in obtaining the information. It will be decentralized and will supplement other agency and commercial information dissemination mechanisms. The public will use GILS directly or through intermediaries, including the Government Printing Office and the National Technical Information Service, as well as federal depository libraries, other public libraries, and private sector information services. Direct users will have access to a GILS Core accessible on the Internet without charge. Intermediate access may include kiosks, 800 numbers, electronic mail, bulletin boards, FAX, and offline media such as floppy disks, CD-ROM, and printed works. GILS will use network technology and the American National Standards Institute Z39.50 standard for information search and retrieval so that information can be retrieved in a variety of ways. Direct users may have access to many other major federal and nonfederal information resources, linkages to data systems, and electronic delivery of information products. An Office of Management and Budget Bulletin in 1994 will provide implementing guidance to agencies. The National Institute of Standards and Technology will also establish a Federal Information Processing Standard specifying a GILS Profile and its application for agencies establishing information locators. ?? 1994.

Assessment and Applications of NASA Ozone Data Products Derived from Aura OMI-MLS Satellite Measurements in Context of the GMI Chemical Transport Model

NASA Technical Reports Server (NTRS)

Ziemke, J. R.; Olsen, M. A.; Witte, J. C.; Douglass, A. R.; Strahan, S. E.; Wargan, K.; Liu, X.; Schoeberl, M. R.; Yang, K.; Kaplan, T. B.;

Safety assessment of plant varieties using transcriptomics profiling and a one-class classifier.

PubMed

van Dijk, Jeroen P; de Mello, Carla Souza; Voorhuijzen, Marleen M; Hutten, Ronald C B; Arisi, Ana Carolina Maisonnave; Jansen, Jeroen J; Buydens, Lutgarde M C; van der Voet, Hilko; Kok, Esther J

2014-10-01

An important part of the current hazard identification of novel plant varieties is comparative targeted analysis of the novel and reference varieties. Comparative analysis will become much more informative with unbiased analytical approaches, e.g. omics profiling. Data analysis estimating the similarity of new varieties to a reference baseline class of known safe varieties would subsequently greatly facilitate hazard identification. Further biological and eventually toxicological analysis would then only be necessary for varieties that fall outside this reference class. For this purpose, a one-class classifier tool was explored to assess and classify transcriptome profiles of potato (Solanum tuberosum) varieties in a model study. Profiles of six different varieties, two locations of growth, two year of harvest and including biological and technical replication were used to build the model. Two scenarios were applied representing evaluation of a 'different' variety and a 'similar' variety. Within the model higher class distances resulted for the 'different' test set compared with the 'similar' test set. The present study may contribute to a more global hazard identification of novel plant varieties. Copyright © 2014 Elsevier Inc. All rights reserved.

Identification of ballast water discharge profiles of a port to enable effective ballast water management and environmental studies

NASA Astrophysics Data System (ADS)

David, Matej; Gollasch, Stephan; Penko, Ludvik

2018-03-01

Information about the profile of ballast water discharges in a port is one of the basic elements of the decision making process in ballast water risk assessment and management, and supports the evaluation of dimensions and processes of aquatic species invasions with vessels ballast water. In the lack of ballast water reporting, ballast water discharge assessments need to be conducted. In this study we have assessed and compared ballast water discharge profiles of two ports with different maritime traffic and cargo profiles, the Port of Hamburg (Germany) and the Muuga Harbour, Port of Tallinn (Estonia). This study shows methods and approaches which can be used to assess volumes and donor ports of ballast water discharges for a port at the level of each vessel call. These methods and approaches can be applied to any port to support the implementation of feasible and efficient ballast water management measures and to enable environmental studies including long-term accumulation risks of disinfection by-products from ballast water management systems making use of active substances, as well as for discharges of other chemical compounds.

Profile of advanced nursing practice in Spain: A cross-sectional study.

PubMed

Sevilla Guerra, Sonia; Miranda Salmerón, Josep; Zabalegui, Adelaida

2018-03-01

In this study, we described the profile of advanced nursing practice in Spain. A cross-sectional study design was used to explore the extent and patterns of advanced nursing practice activity within the domains of expert care planning, integrated care, interprofessional collaboration, education, research, evidence-based practice, and professional leadership. Data were collected in 2015/2016. Purposive sampling yielded a sample of 165 specialist and expert nurses employed by a dual tertiary and community hospital in an urban setting. The study included specialist and expert nurses who had a higher practice profile than registered general nurses. The performance of activities according to age, current position, years of experience, nursing grade, and education was compared. Practice domains were more strongly influenced by the predictors of nursing position and professional career ladder. Age and experience predictors were found to be weak predictors of advanced practice domains. This study offers essential information of the nursing workforce, and clarifies both the advanced nursing practice profile and nomenclature in the context of study. © 2017 John Wiley & Sons Australia, Ltd.

Comprehensive Molecular Profiling of African-American Prostate Cancer to Inform on Prognosis and Disease Biology

DTIC Science & Technology

2017-10-01

development and patterning, and to become more knowledgeable in molecular genetics and the pathology of human prostatic diseases. Specific Aims: 1...AWARD NUMBER: W81XWH-15-1-0661 TITLE: Comprehensive Molecular Profiling of African-American Prostate Cancer to Inform on Prognosis and...COVERED 30 Sept 2016 – 29 Sept 2017 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Comprehensive Molecular Profiling of African-American Prostate Cancer to

Utilizing novel diversity estimators to quantify multiple dimensions of microbial biodiversity across domains

PubMed Central

2013-01-01

Background Microbial ecologists often employ methods from classical community ecology to analyze microbial community diversity. However, these methods have limitations because microbial communities differ from macro-organismal communities in key ways. This study sought to quantify microbial diversity using methods that are better suited for data spanning multiple domains of life and dimensions of diversity. Diversity profiles are one novel, promising way to analyze microbial datasets. Diversity profiles encompass many other indices, provide effective numbers of diversity (mathematical generalizations of previous indices that better convey the magnitude of differences in diversity), and can incorporate taxa similarity information. To explore whether these profiles change interpretations of microbial datasets, diversity profiles were calculated for four microbial datasets from different environments spanning all domains of life as well as viruses. Both similarity-based profiles that incorporated phylogenetic relatedness and naïve (not similarity-based) profiles were calculated. Simulated datasets were used to examine the robustness of diversity profiles to varying phylogenetic topology and community composition. Results Diversity profiles provided insights into microbial datasets that were not detectable with classical univariate diversity metrics. For all datasets analyzed, there were key distinctions between calculations that incorporated phylogenetic diversity as a measure of taxa similarity and naïve calculations. The profiles also provided information about the effects of rare species on diversity calculations. Additionally, diversity profiles were used to examine thousands of simulated microbial communities, showing that similarity-based and naïve diversity profiles only agreed approximately 50% of the time in their classification of which sample was most diverse. This is a strong argument for incorporating similarity information and calculating diversity with a range of emphases on rare and abundant species when quantifying microbial community diversity. Conclusions For many datasets, diversity profiles provided a different view of microbial community diversity compared to analyses that did not take into account taxa similarity information, effective diversity, or multiple diversity metrics. These findings are a valuable contribution to data analysis methodology in microbial ecology. PMID:24238386

Building America Top Innovations 2013 Profile – Building America Solution Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2013-09-01

This Top Innovation profile provides information about the Building America Solution Center created by Pacific Northwest National Laboratory, a web tool connecting users to thousands of pieces of building science information developed by DOE’s Building America research partners.

The Predictive Effects of Early Pregnancy Lipid Profiles and Fasting Glucose on the Risk of Gestational Diabetes Mellitus Stratified by Body Mass Index.

PubMed

Wang, Chen; Zhu, Weiwei; Wei, Yumei; Su, Rina; Feng, Hui; Lin, Li; Yang, Huixia

2016-01-01

This study aimed at evaluating the predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus (GDM) in patients stratified by prepregnancy body mass index (p-BMI) and to determine the optimal cut-off values of each indicator for different p-BMI ranges. A retrospective system cluster sampling survey was conducted in Beijing during 2013 and a total of 5,265 singleton pregnancies without prepregnancy diabetes were included. The information for each participant was collected individually using questionnaires and medical records. Logistic regression analysis and receiver operator characteristics analysis were used in the analysis. Outcomes showed that potential markers for the prediction of GDM include early pregnancy lipid profiles (cholesterol, triacylglycerols, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios [LDL-C/HDL-C], and triglyceride to high-density lipoprotein cholesterol ratios [TG/HDL-C]) and fasting glucose, of which fasting glucose level was the most accurate indicator. Furthermore, the predictive effects and cut-off values for these factors varied according to p-BMI. Thus, p-BMI should be a consideration for the risk assessment of pregnant patients for GDM development.

Protected health information on social networking sites: ethical and legal considerations.

PubMed

Thompson, Lindsay A; Black, Erik; Duff, W Patrick; Paradise Black, Nicole; Saliba, Heidi; Dawson, Kara

2011-01-19

Social networking site use is increasingly common among emerging medical professionals, with medical schools even reporting disciplinary student expulsion. Medical professionals who use social networking sites have unique responsibilities since their postings could violate patient privacy. However, it is unknown whether students and residents portray protected health information and under what circumstances or contexts. The objective of our study was to document and describe online portrayals of potential patient privacy violations in the Facebook profiles of medical students and residents. A multidisciplinary team performed two cross-sectional analyses at the University of Florida in 2007 and 2009 of all medical students and residents to see who had Facebook profiles. For each identified profile, we manually scanned the entire profile for any textual or photographic representations of protected health information, such as portrayals of people, names, dates, or descriptions of procedures. Almost half of all eligible students and residents had Facebook profiles (49.8%, or n=1023 out of 2053). There were 12 instances of potential patient violations, in which students and residents posted photographs of care they provided to individuals. No resident or student posted any identifiable patient information or likeness in text form. Each instance occurred in developing countries on apparent medical mission trips. These portrayals increased over time (1 in the 2007 cohort; 11 in 2009; P = .03). Medical students were more likely to have these potential violations on their profiles than residents (11 vs 1, P = .04), and there was no difference by gender. Photographs included trainees interacting with identifiable patients, all children, or performing medical examinations or procedures such as vaccinations of children. While students and residents in this study are posting photographs that are potentially violations of patient privacy, they only seem to make this lapse in the setting of medical mission trips. Trainees need to learn to equate standards of patient privacy in all medical contexts using both legal and ethical arguments to maintain the highest professional principles. We propose three practical guidelines. First, there should be a legal resource for physicians traveling on medical mission trips such as an online list of local laws, or a telephone legal contact. Second, institutions that organize medical mission trips should plan an ethics seminar prior the departure on any trip since the legal and ethical implications may not be intuitive. Finally, at minimum, traveling physicians should apply the strictest legal precedent to any situation.

Protected Health Information on Social Networking Sites: Ethical and Legal Considerations

PubMed Central

2011-01-01

Background Social networking site use is increasingly common among emerging medical professionals, with medical schools even reporting disciplinary student expulsion. Medical professionals who use social networking sites have unique responsibilities since their postings could violate patient privacy. However, it is unknown whether students and residents portray protected health information and under what circumstances or contexts. Objective The objective of our study was to document and describe online portrayals of potential patient privacy violations in the Facebook profiles of medical students and residents. Methods A multidisciplinary team performed two cross-sectional analyses at the University of Florida in 2007 and 2009 of all medical students and residents to see who had Facebook profiles. For each identified profile, we manually scanned the entire profile for any textual or photographic representations of protected health information, such as portrayals of people, names, dates, or descriptions of procedures. Results Almost half of all eligible students and residents had Facebook profiles (49.8%, or n=1023 out of 2053). There were 12 instances of potential patient violations, in which students and residents posted photographs of care they provided to individuals. No resident or student posted any identifiable patient information or likeness in text form. Each instance occurred in developing countries on apparent medical mission trips. These portrayals increased over time (1 in the 2007 cohort; 11 in 2009; P = .03). Medical students were more likely to have these potential violations on their profiles than residents (11 vs 1, P = .04), and there was no difference by gender. Photographs included trainees interacting with identifiable patients, all children, or performing medical examinations or procedures such as vaccinations of children. Conclusions While students and residents in this study are posting photographs that are potentially violations of patient privacy, they only seem to make this lapse in the setting of medical mission trips. Trainees need to learn to equate standards of patient privacy in all medical contexts using both legal and ethical arguments to maintain the highest professional principles. We propose three practical guidelines. First, there should be a legal resource for physicians traveling on medical mission trips such as an online list of local laws, or a telephone legal contact. Second, institutions that organize medical mission trips should plan an ethics seminar prior the departure on any trip since the legal and ethical implications may not be intuitive. Finally, at minimum, traveling physicians should apply the strictest legal precedent to any situation. PMID:21247862

Australian Seismological Reference Model (AuSREM): crustal component

NASA Astrophysics Data System (ADS)

Salmon, M.; Kennett, B. L. N.; Saygin, E.

2013-01-01

Although Australia has been the subject of a wide range of seismological studies, these have concentrated on specific features of the continent at crustal scales and on the broad scale features in the mantle. The Australian Seismological Reference Model (AuSREM) is designed to bring together the existing information, and provide a synthesis in the form of a 3-D model that can provide the basis for future refinement from more detailed studies. Extensive studies in the last few decades provide good coverage for much of the continent, and the crustal model builds on the various data sources to produce a representative model that captures the major features of the continental structure and provides a basis for a broad range of further studies. The model is grid based with a 0.5° sampling in latitude and longitude, and is designed to be fully interpolable, so that properties can be extracted at any point. The crustal structure is built from five-layer representations of refraction and receiver function studies and tomographic information. The AuSREM crustal model is available at 1 km intervals. The crustal component makes use of prior compilations of sediment thicknesses, with cross checks against recent reflection profiling, and provides P and S wavespeed distributions through the crust. The primary information for P wavespeed comes from refraction profiles, for S wavespeed from receiver function studies. We are also able to use the results of ambient noise tomography to link the point observations into national coverage. Density values are derived using results from gravity interpretations with an empirical relation between P wavespeed and density. AuSREM is able to build on a new map of depth to Moho, which has been created using all available information including Moho picks from over 12 000 km of full crustal profiling across the continent. The crustal component of AuSREM provides a representative model that should be useful for modelling of seismic wave propagation and calculation of crustal corrections for tomography. Other applications include gravity studies and dynamic topography at the continental scale.

The IEO Data Center Management System: Tools for quality control, analysis and access marine data

NASA Astrophysics Data System (ADS)

Casas, Antonia; Garcia, Maria Jesus; Nikouline, Andrei

2010-05-01

Since 1994 the Data Centre of the Spanish Oceanographic Institute develops system for archiving and quality control of oceanographic data. The work started in the frame of the European Marine Science & Technology Programme (MAST) when a consortium of several Mediterranean Data Centres began to work on the MEDATLAS project. Along the years, old software modules for MS DOS were rewritten, improved and migrated to Windows environment. Oceanographic data quality control includes now not only vertical profiles (mainly CTD and bottles observations) but also time series of currents and sea level observations. New powerful routines for analysis and for graphic visualization were added. Data presented originally in ASCII format were organized recently in an open source MySQL database. Nowadays, the IEO, as part of SeaDataNet Infrastructure, has designed and developed a new information system, consistent with the ISO 19115 and SeaDataNet standards, in order to manage the large and diverse marine data and information originated in Spain by different sources, and to interoperate with SeaDataNet. The system works with data stored in ASCII files (MEDATLAS, ODV) as well as data stored within the relational database. The components of the system are: 1.MEDATLAS Format and Quality Control - QCDAMAR: Quality Control of Marine Data. Main set of tools for working with data presented as text files. Includes extended quality control (searching for duplicated cruises and profiles, checking date, position, ship velocity, constant profiles, spikes, density inversion, sounding, acceptable data, impossible regional values,...) and input/output filters. - QCMareas: A set of procedures for the quality control of tide gauge data according to standard international Sea Level Observing System. These procedures include checking for unexpected anomalies in the time series, interpolation, filtering, computation of basic statistics and residuals. 2. DAMAR: A relational data base (MySql) designed to manage the wide variety of marine information as common vocabularies, Catalogues (CSR & EDIOS), Data and Metadata. 3.Other tools for analysis and data management - Import_DB: Script to import data and metadata from the Medatlas ASCII files into the database. - SelDamar/Selavi: interface with the database for local and web access. Allows selective retrievals applying the criteria introduced by the user, as geographical bounds, data responsible, cruises, platform, time periods, etc. Includes also statistical reference values calculation, plotting of original and mean profiles together with vertical interpolation. - ExtractDAMAR: Script to extract data when they are archived in ASCII files that meet the criteria upon an user request through SelDamar interface and export them in ODV format, making also a unit conversion.

Donor profiles: demographic factors and their influence on the donor career.

PubMed

Veldhuizen, I J T; Doggen, C J M; Atsma, F; De Kort, W L A M

2009-08-01

Studying the contribution of demographic factors to the donor career provides important knowledge to be used for donor management. The aim of this study is to gain insight into donor characteristics, more specifically into the demographic profile of active vs. resigned donors, and multi-gallon vs. occasional donors. The study population consisted of all registered Dutch whole-blood donors between 1 January 2004 and 1 January 2005 (N = 370 470). The effect of several blood donor characteristics and demographic variables on (i) resigning donating and (ii) being a multi-gallon donor were assessed. Blood donor characteristics were extracted from the blood bank information system and included age, sex, blood group, number of donations and invitations. Demographic characteristics were constituted by population data on urbanization level, socio-economic status (income, housing value), and ethnicity. Men clearly resigned less often than women (odds ratio (OR) 0.73, 95% confidence interval (CI) 0.72-0.75). Being older than 24 years, having a high income, a high-priced house, living in less urbanized areas or areas with relatively few ethnically diverse people also reduced the stopping risk. With respect to multi-gallon donorship, men were five times more often multi-gallon donor than women (OR 5.27, 95% CI 5.15-5.39) irrespective of the number of donation invitations. Furthermore, multi-gallon donors appeared to live in urbanized areas and have a higher income than occasional donors. Our results show that different donor profiles can be distinguished. Differences between active and resigned donors include age, the number of donations, sex, socio-economic-status, ethnicity, and urbanization level. The factors highly associated with being a multi-gallon donor are sex, age, socio-economic status, and to a lesser extent urbanization level. Donor profiles do provide the blood bank with knowledge on their donor population, which may be used as valuable information for donor recruitment and retention policies.

Defining the limits of physiological plasticity: how gene expression can assess and predict the consequences of ocean change

PubMed Central

Evans, Tyler G.; Hofmann, Gretchen E.

2012-01-01

Anthropogenic stressors, such as climate change, are driving fundamental shifts in the abiotic characteristics of marine ecosystems. As the environmental aspects of our world's oceans deviate from evolved norms, of major concern is whether extant marine species possess the capacity to cope with such rapid change. In what many scientists consider the post-genomic era, tools that exploit the availability of DNA sequence information are being increasingly recognized as relevant to questions surrounding ocean change and marine conservation. In this review, we highlight the application of high-throughput gene-expression profiling, primarily transcriptomics, to the field of marine conservation physiology. Through the use of case studies, we illustrate how gene expression can be used to standardize metrics of sub-lethal stress, track organism condition in natural environments and bypass phylogenetic barriers that hinder the application of other physiological techniques to conservation. When coupled with fine-scale monitoring of environmental variables, gene-expression profiling provides a powerful approach to conservation capable of informing diverse issues related to ocean change, from coral bleaching to the spread of invasive species. Integrating novel approaches capable of improving existing conservation strategies, including gene-expression profiling, will be critical to ensuring the ecological and economic health of the global ocean. PMID:22566679

Portfolio of Outpatients Attending Centre for Urban Health, Madhya Pradesh, Central India.

PubMed

Gupta, Arti; Reddy, B Venkatashiva; Nagar, Mukesh Kumar; Chandel, Ajeet; Bali, Surya

2015-01-01

Knowledge on distribution and burden of diseases in a community is essential for planning of public health services. In the absence of information on morbidity profile through community-based surveys, facility-based data provide a good alternative. The aim of this study was to describe the morbidity profile of patients attending the Centre for Urban Health All India Institute of Medical Sciences (AIIMS) Bhopal (CUHA). A record-based descriptive study was carried out in the CUHA Bhopal, Madhya Pradesh, Central India. Information on age, gender, residence, new case, and principal diagnosis were extracted from the outpatient registers for the period between January 2014 and December 2014. Only newly registered patients for the study year (2014) were included. Descriptive analysis was done. A total of 6685 new episodes of illnesses were treated. Adults (>15 years) constituted about 85.0%. Overall, the respiratory disorders were the most common (27.2%) followed by the digestive disorders (10.9%), circulatory disorders (9.9%), musculoskeletal disorders (8.8%), and infectious and parasitic disorders (7.4%). This study gives a brief description of the morbidity profile of patients attending a primary health care center over a period of 1 year. This knowledge would help in planning health services to meet the patients' needs and help in training health staff.

Nimbus 7 solar backscatter ultraviolet (SBUV) ozone products user's guide

NASA Technical Reports Server (NTRS)

Fleig, Albert J.; Mcpeters, R. D.; Bhartia, P. K.; Schlesinger, Barry M.; Cebula, Richard P.; Klenk, K. F.; Taylor, Steven L.; Heath, Donald F.

1990-01-01

Three ozone tape products from the Solar Backscatter Ultraviolet (SBUV) experiment aboard Nimbus 7 were archived at the National Space Science Data Center. The experiment measures the fraction of incoming radiation backscattered by the Earth's atmosphere at 12 wavelengths. In-flight measurements were used to monitor changes in the instrument sensitivity. Total column ozone is derived by comparing the measurements with calculations of what would be measured for different total ozone amounts. The altitude distribution is retrieved using an optimum statistical technique for the inversion. The estimated initial error in the absolute scale for total ozone is 2 percent, with a 3 percent drift over 8 years. The profile error depends on latitude and height, smallest at 3 to 10 mbar; the drift increases with increasing altitude. Three tape products are described. The High Density SBUV (HDSBUV) tape contains the final derived products - the total ozone and the vertical ozone profile - as well as much detailed diagnostic information generated during the retrieval process. The Compressed Ozone (CPOZ) tape contains only that subset of HDSBUV information, including total ozone and ozone profiles, considered most useful for scientific studies. The Zonal Means Tape (ZMT) contains daily, weekly, monthly and quarterly averages of the derived quantities over 10 deg latitude zones.

General Aviation in Nebraska: Nebraska SATS Project Background Paper No. 1

NASA Technical Reports Server (NTRS)

Smith, Russell; Wachal, Jocelyn

2000-01-01

The Nebraska SATS project is a state-level component of NASA's Small Aircraft Transportation System (SATS). During the next several years the project will examine several different factors affecting SATS implementation in Nebraska. These include economic and taxation issues, public policy issues, airport planning processes, information dissemination strategies, and systemic change factors. This background paper profiles the general aviation system in Nebraska. It is written to provide information about the "context" within which SATS will be pursued. The primary focus is thus on describing and providing background information about the current situation. A secondary focus is on drawing general conclusions about the ability of the current system to incorporate the types of changes implied by SATS. First, some brief information on the U.S. aviation system is provided. The next two sections profile the current general aviation aircraft and pilot base. Nebraska's system of general aviation airports is then described. Within this section of the paper, information is provided on the different types of general aviation airports in Nebraska, airport activity levels and current infrastructure. The fourth major section of the background paper looks at Nebraska's local airport authorities. These special purpose local governments oversee the majority of the general aviation airports in the state. Among the items examined are total expenditures, capital expenditures and planning activities. Next, the paper provides background information on the Nebraska Department of Aeronautics (NDA) and recent Federal funding for general aviation in Nebraska. The final section presents summary conclusions.

Physical activity and sleep profiles in Finnish men and women.

PubMed

Wennman, Heini; Kronholm, Erkki; Partonen, Timo; Tolvanen, Asko; Peltonen, Markku; Vasankari, Tommi; Borodulin, Katja

2014-01-27

Physical activity (PA) and sleep are related to cardiovascular diseases (CVD) and their risk factors. The interrelationship between these behaviors has been studied, but there remain questions regarding the association of different types of PA, such as occupational, commuting, and leisure time to sleep, including quality, duration and sufficiency. It is also unclear to what extent sleep affects peoples' PA levels and patterns. Our aim is to investigate the interrelationship between PA and sleep behaviors in the Finnish population, including employment status and gender. The study comprised population based data from the FINRISK 2012 Study. A stratified, random sample of 10,000 Finns, 25 to 74 years-old, were sent a questionnaire and an invitation to a health examination. The participation rate was 64% (n = 6,414). Latent class analysis was used to search for different underlying profiles of PA and sleep behavior in men and women, respectively. Models with one through five latent profiles were fitted to the data. Based on fit indicators, a four-class model for men and women, respectively, was decided to be the best fitted model. Four different profiles of PA and sleep were found in both men and women. The most common profile of men comprised 45% of the total participants, and in women, 47%. These profiles were distinguished by probabilities for high leisure time PA and sleep, subjectively rated as sufficient, as well as sleep duration of 7-7.9 hours. The least common profiles represented 5% (men) and 11% (women) of the population, and were characterized by probabilities for physical inactivity, short sleep, and evening type for women and morning type for men. There was also one profile in both genders characterized by likelihood for both high occupational PA and subjectively experienced insufficient sleep. The use of latent class analysis in investigating the interrelationship between PA and sleep is a novel perspective. The method provides information on the clustering of behaviors in people and the profiles found suggest an accumulative nature of leisure time PA, and better sleep. Our data also suggest that high levels of occupational PA are associated with shorter and poorer sleep.

Energy information systems (EIS): Technology costs, benefit, and best practice uses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Granderson, Jessica; Lin, Guanjing; Piette, Mary Ann

2013-11-26

Energy information systems are the web-based software, data acquisition hardware, and communication systems used to store, analyze, and display building energy data. They often include analysis methods such as baselining, benchmarking, load profiling, and energy anomaly detection. This report documents a large-scale assessment of energy information system (EIS) uses, costs, and energy benefits, based on a series of focused case study investigations that are synthesized into generalizable findings. The overall objective is to provide organizational decision makers with the information they need to make informed choices as to whether or not to invest in an EIS--a promising technology that canmore » enable up to 20 percent site energy savings, quick payback, and persistent low-energy performance when implemented as part of best-practice energy management programs.« less

Using a graphical risk tool to examine willingness to take migraine prophylactic medications.

PubMed

Turner, Dana P; Golding, Adrienne N; Houle, Timothy T

2016-10-01

Many migraine sufferers use daily prophylactic therapy to reduce the frequency of their headache attacks. The Food and Drug Administration has approved several different medications for migraine prophylaxis, but it is not clear whether sufferers perceive these treatments to provide clinically significant benefits given their side effect profiles. Three hundred headache sufferers were recruited from the community and local headache clinics using print and television advertising. Participants reported experiencing problematic headache attacks with a median (IQR) frequency of 7.0 (4-13) headache days per month. These sufferers participated in a cross-sectional, single-site, study that used a specially designed computer assessment task. Participants were instructed on the probability of experiencing the 3 most commonly experienced side effects for several blinded medication profiles: divalproex sodium, venlafaxine, gabapentin, propranolol, and topiramate. After learning the likelihood of experiencing side effect profiles of each medication, participants were asked whether they would be willing to take the medication for a given headache reduction level, which ranged from 0 to 7 days per month. The side effect profile for divalproex sodium was associated with the smallest willingness to take, with gabapentin, propranolol, and topiramate perceived to be much more agreeable. However, <60% of participants reported willingness to take any of these medications even if they provided a 50% reduction in headache frequency. Several general predictors of willingness to take were observed including high headache-related disability, depressive symptoms, and pain medication concerns including fear of tolerance. These findings suggest that if properly informed of the side effect profiles of these medications, many patients might opt for other treatments.

NCIP Profiles, 1-5, 1995.

ERIC Educational Resources Information Center

NCIP Profiles, 1995

1995-01-01

This set of information sheets is intended to improve practice in special education through technology, media, and materials. The first information profile introduces NCIP (the National Center to Improve Practice), gives an example of how one special education administrator uses NCIP resources, and offers suggestions for facilitating NCIP…

Towards a Ubiquitous User Model for Profile Sharing and Reuse

PubMed Central

de Lourdes Martinez-Villaseñor, Maria; Gonzalez-Mendoza, Miguel; Hernandez-Gress, Neil

2012-01-01

People interact with systems and applications through several devices and are willing to share information about preferences, interests and characteristics. Social networking profiles, data from advanced sensors attached to personal gadgets, and semantic web technologies such as FOAF and microformats are valuable sources of personal information that could provide a fair understanding of the user, but profile information is scattered over different user models. Some researchers in the ubiquitous user modeling community envision the need to share user model's information from heterogeneous sources. In this paper, we address the syntactic and semantic heterogeneity of user models in order to enable user modeling interoperability. We present a dynamic user profile structure based in Simple Knowledge Organization for the Web (SKOS) to provide knowledge representation for ubiquitous user model. We propose a two-tier matching strategy for concept schemas alignment to enable user modeling interoperability. Our proposal is proved in the application scenario of sharing and reusing data in order to deal with overweight and obesity. PMID:23201995

Bridge-scour analysis using the water surface profile (WSPRO) model

USGS Publications Warehouse

Mueller, David S.; ,

1993-01-01

A program was developed to extract hydraulic information required for bridge-scour computations, from the Water-Surface Profile computation model (WSPRO). The program is written in compiled BASIC and is menu driven. Using only ground points, the program can compute average ground elevation, cross-sectional area below a specified datum, or create a Drawing Exchange Format (DXF) fie of cross section. Using both ground points ad hydraulic information form the equal-conveyance tubes computed by WSPRO, the program can compute hydraulic parameters at a user-specified station or in a user-specified subsection of the cross section. The program can identify the maximum velocity in a cross section and the velocity and depth at a user-specified station. The program also can identify the maximum velocity in the cross section and the average velocity, average depth, average ground elevation, width perpendicular to the flow, cross-sectional area of flow, and discharge in a subsection of the cross section. This program does not include any help or suggestions as to what data should be extracted; therefore, the used must understand the scour equations and associated variables to the able to extract the proper information from the WSPRO output.

Association of Chronic Subjective Tinnitus with Neuro- Cognitive Performance.

PubMed

Gudwani, Sunita; Munjal, Sanjay K; Panda, Naresh K; Kohli, Adarsh

2017-12-01

Chronic subjective tinnitus is associated with cognitive disruptions affecting perception, thinking, language, reasoning, problem solving, memory, visual tasks (reading) and attention. To evaluate existence of any association between tinnitus parameters and neuropsychological performance to explain cognitive processing. Study design was prospective, consisting 25 patients with idiopathic chronic subjective tinnitus and gave informed consent before planning their treatment. Neuropsychological profile included (i) performance on verbal information, comprehension, arithmetic and digit span; (ii) non-verbal performance for visual pattern completion analogies; (iii) memory performance for long-term, recent, delayed-recall, immediate-recall, verbal-retention, visualretention, visual recognition; (iv) reception, interpretation and execution for visual motor gestalt. Correlation between tinnitus onset duration/ loudness perception with neuropsychological profile was assessed by calculating Spearman's coefficient. Findings suggest that tinnitus may interfere with cognitive processing especially performance on digit span, verbal comprehension, mental balance, attention & concentration, immediate recall, visual recognition and visual-motor gestalt subtests. Negative correlation between neurocognitive tasks with tinnitus loudness and onset duration indicated their association. Positive correlation between tinnitus and visual-motor gestalt performance indicated the brain dysfunction. Tinnitus association with non-auditory processing of verbal, visual and visuo-spatial information suggested neuroplastic changes that need to be targeted in cognitive rehabilitation.

Massively parallel sequencing of forensic STRs and SNPs using the Illumina® ForenSeq™ DNA Signature Prep Kit on the MiSeq FGx™ Forensic Genomics System.

PubMed

Guo, Fei; Yu, Jiao; Zhang, Lu; Li, Jun

2017-11-01

The ForenSeq™ DNA Signature Prep Kit (ForenSeq Kit) is designed to detect more than 200 forensically relevant markers in a single reaction on the MiSeq FGx™ Forensic Genomics System (MiSeq FGx System), including Amelogenin, 27 autosomal short tandem repeats (A-STRs), 7 X chromosomal STRs (X-STRs), 24 Y chromosomal STRs (Y-STRs) and 94 identity-informative single nucleotide polymorphisms (iSNPs) with the option to contain 22 phenotypic-informative SNPs (pSNPs) and 56 ancestry-informative SNPs (aSNPs). In this study, we evaluated the MiSeq FGx System on three major parts: methodological optimization (DNA extraction, sample quantification, library normalization, diluted libraries concentration, and sample-to-cell arrangement), massively parallel sequencing (MPS) performance (depth of coverage, sequence coverage ratio, and allele coverage ratio), and ForenSeq Kit characteristics (repeatability and concordance, sensitivity, mixture, stability and case-type samples). Results showed that quantitative polymerase chain reaction (qPCR)-based sample quantification and library normalization and the appropriate number of pooled libraries and concentration of diluted libraries provided a greater level of MPS performance and repeatability. Repeatable and concordant genotypes were obtained by the ForenSeq Kit. Full profiles were obtained from ≥100pg input DNA for STRs and ≥200pg for SNPs. A sample with ≥5% minor contributors was considered as a mixture by imbalanced allele coverage ratio distribution, and full profiles from minor contributors were easily detected between 9:1 and 1:9 mixtures with known reference profiles. The ForenSeq Kit tolerated considerable concentrations of inhibitors like ≤200μM hematin and ≤50μg/ml humic acid, and >56% STR profiles and >88% SNP profiles were obtained from ≥200-bp degraded samples. Also, it was adapted to case-type samples. As a whole, the ForenSeq Kit is a well-performed, robust, reliable, reproducible and highly informative assay, and it can fully meet requirements for human identification. Further, sensitive QC indicator and automated sample comparison function in the ForenSeq™ Universal Analysis Software are quite helpful, so that we can concentrate on questionable genotypes and avoid tedious and time-consuming labor to maximum the time spent in data analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

Impact of Eclipse of 21 August 2017 ON the Atmospheric Boundary Layer

NASA Astrophysics Data System (ADS)

Knupp, K.

2017-12-01

The (total) solar eclipse of 21 August 2017 presents a prodigious opportunity to improve our understanding of the physical response of decreases in turbulence within the ABL produced by a rapid reduction in solar radiation, since the transition in this eclipse case, close to local solar noon, is more rapid than at natural sunset. A mesoscale network of three UAH atmospheric profiling systems will be set up around Clarksville, TN, and Hopkinsville, KY, to document the details of the physical response of the ABL to the rapid decrease in solar radiation. The region offers a heterogeneous surface, including expansive agricultural and forested regions. Data from the following mobile systems will be examined: Mobile Integrated Profiling System (MIPS) with a 915 MHz Doppler wind profiler, X-band Profiling Radar (XPR), Microwave Profiling Radiometer (MPR), lidar ceilometer, and Doppler mini-sodar, Rapidly Deployable Atmospheric Profiling System (RaDAPS) with a 915 MHz Doppler wind profiler, MPR, lidar ceilometer, Doppler mini-sodar, Mobile Doppler Lidar and Sounding system (MoDLS) with a Doppler Wind Lidar and MPR. A tethered balloon will provide high temporal and vertical resolution in situ sampling of the surface layer temperature and humidity vertical profiles over the lowest 120 m AGL. Two of the profiling systems (MIPS and MoDLS) will include 20 Hz sonic anemometer measurements for documentation of velocity component (u, v, w) variance, buoyancy flux, and momentum flux. The Mobile Alabama X-band (MAX) dual polarization radar will be paired with the Ft. Campbell WSR-88D radar, located 29 km east of the MAX, to provide dual Doppler radar coverage of flow within the ABL over the profiler domain. The measurements during this eclipse will also provide information on the response of insects to rapidly changing lighting conditions. During the natural afternoon-to-evening transition, daytime insect concentrations decrease rapidly, and stronger-flying nighttime flyers emerge rapidly following sunset. We hypothesize that a similar transition will occur on a limited basis: nighttime flyers will emerge, but the daytime flyers will not rapidly disappear due to the short time scale of the darkness. This insect transition will be measured with the radar wind profilers and the MAX and WSR-88D dual polarization radars.

VitisExpDB: a database resource for grape functional genomics.

PubMed

Doddapaneni, Harshavardhan; Lin, Hong; Walker, M Andrew; Yao, Jiqiang; Civerolo, Edwin L

2008-02-28

The family Vitaceae consists of many different grape species that grow in a range of climatic conditions. In the past few years, several studies have generated functional genomic information on different Vitis species and cultivars, including the European grape vine, Vitis vinifera. Our goal is to develop a comprehensive web data source for Vitaceae. VitisExpDB is an online MySQL-PHP driven relational database that houses annotated EST and gene expression data for V. vinifera and non-vinifera grape species and varieties. Currently, the database stores approximately 320,000 EST sequences derived from 8 species/hybrids, their annotation (BLAST top match) details and Gene Ontology based structured vocabulary. Putative homologs for each EST in other species and varieties along with information on their percent nucleotide identities, phylogenetic relationship and common primers can be retrieved. The database also includes information on probe sequence and annotation features of the high density 60-mer gene expression chip consisting of approximately 20,000 non-redundant set of ESTs. Finally, the database includes 14 processed global microarray expression profile sets. Data from 12 of these expression profile sets have been mapped onto metabolic pathways. A user-friendly web interface with multiple search indices and extensively hyperlinked result features that permit efficient data retrieval has been developed. Several online bioinformatics tools that interact with the database along with other sequence analysis tools have been added. In addition, users can submit their ESTs to the database. The developed database provides genomic resource to grape community for functional analysis of genes in the collection and for the grape genome annotation and gene function identification. The VitisExpDB database is available through our website http://cropdisease.ars.usda.gov/vitis_at/main-page.htm.

VitisExpDB: A database resource for grape functional genomics

PubMed Central

Doddapaneni, Harshavardhan; Lin, Hong; Walker, M Andrew; Yao, Jiqiang; Civerolo, Edwin L

2008-01-01

Background The family Vitaceae consists of many different grape species that grow in a range of climatic conditions. In the past few years, several studies have generated functional genomic information on different Vitis species and cultivars, including the European grape vine, Vitis vinifera. Our goal is to develop a comprehensive web data source for Vitaceae. Description VitisExpDB is an online MySQL-PHP driven relational database that houses annotated EST and gene expression data for V. vinifera and non-vinifera grape species and varieties. Currently, the database stores ~320,000 EST sequences derived from 8 species/hybrids, their annotation (BLAST top match) details and Gene Ontology based structured vocabulary. Putative homologs for each EST in other species and varieties along with information on their percent nucleotide identities, phylogenetic relationship and common primers can be retrieved. The database also includes information on probe sequence and annotation features of the high density 60-mer gene expression chip consisting of ~20,000 non-redundant set of ESTs. Finally, the database includes 14 processed global microarray expression profile sets. Data from 12 of these expression profile sets have been mapped onto metabolic pathways. A user-friendly web interface with multiple search indices and extensively hyperlinked result features that permit efficient data retrieval has been developed. Several online bioinformatics tools that interact with the database along with other sequence analysis tools have been added. In addition, users can submit their ESTs to the database. Conclusion The developed database provides genomic resource to grape community for functional analysis of genes in the collection and for the grape genome annotation and gene function identification. The VitisExpDB database is available through our website . PMID:18307813

Grinding assembly, grinding apparatus, weld joint defect repair system, and methods

DOEpatents

Larsen, Eric D.; Watkins, Arthur D.; Bitsoi, Rodney J.; Pace, David P.

2005-09-27

A grinding assembly for grinding a weld joint of a workpiece includes a grinder apparatus, a grinder apparatus includes a grinding wheel configured to grind the weld joint, a member configured to receive the grinding wheel, the member being configured to be removably attached to the grinder apparatus, and a sensor assembly configured to detect a contact between the grinding wheel and the workpiece. The grinding assembly also includes a processing circuitry in communication with the grinder apparatus and configured to control operations of the grinder apparatus, the processing circuitry configured to receive weld defect information of the weld joint from an inspection assembly to create a contour grinding profile to grind the weld joint in a predetermined shape based on the received weld defect information, and a manipulator having an end configured to carry the grinder apparatus, the manipulator further configured to operate in multiple dimensions.

How are personality trait and profile agreement related?

PubMed Central

Allik, Jüri; Borkenau, Peter; Hřebíčková, Martina; Kuppens, Peter; Realo, Anu

2015-01-01

It is argued that if we compute self-other agreement on some personality traits then we possess no or very little information about the individuals who are the targets of this judgment. This idea is largely based on two separate ways of computing self-other agreement: trait agreement (rT) and profile agreement (rP), which are typically associated with two different trait-centered and person-centered approaches in personality research. Personality traits of 4115 targets from Czech, Belgian, Estonian, and German samples were rated by themselves and knowledgeable informants. We demonstrate that trait agreement can be partialled into individual contributions so that it is possible to show how much each individual pair of judges contributes to agreement on a particular trait. Similarly, it is possible to decompose agreement between two personality profiles into the individual contributions of traits from which these profiles are assembled. If normativeness is separated from distinctiveness of personality scores and individual profiles are ipsatized, then mean profile agreement rP becomes identical to mean trait agreement rT. The views that trait-by-trait analysis does not provide information regarding accuracy level of a particular pair of judges and profile analysis does not permit assessment of the relative contributions of traits to overall accuracy are not supported. PMID:26106356

Crop identification using Landsat temporal-spectral profiles

NASA Technical Reports Server (NTRS)

Odenweller, J. B.; Johnson, K. I.

1982-01-01

The temporal-spectral profile is a detailed indicator of the physical state of a field through time. Characteristic profiles have been observed for a variety of crops and other cover classes from Landsat data in the United States Corn Belt. These profiles contain information to support crop identification at various levels.

Breakthroughs in Low-Profile Leaky-Wave HPM Antennas

DTIC Science & Technology

2016-09-21

information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and... traveling , fast-wave, leaky-wave class. 1.1. Overview of Previous Activities (1st thru 11th Quarter) During the first quarter, we prepared and...theory to guide the design of high-gain configurations (again, limited to 2D, H-plane representations) for linear, forward traveling -wave, leaky

Geographic Profiling: Knowledge Through Prediction

DTIC Science & Technology

2014-06-01

FTO Foreign Terrorist Organization GIS geographic information systems LE lawless elements MADM multi-attribute decision making MILF Moro Islamic...or her life. Anchor points can include the offender’s home , his or her workplace, a home of a friend of the offender, or even a bar or restaurant...more generally for the improvement of police patrols. In Memphis, TN, city officials have seen a decrease in crime with the help of operation Blue

Sage Gene Expression Profiles Characterizing Cure

DTIC Science & Technology

2006-10-01

including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services , Directorate for Information Operations and...all of which have concluded that the effect is largely consistent among high quality studies. If their breast cancer surgery is done in the luteal...at different phases of the estrous cycle. 2. prepare RNA from tumors using dynel poly-A beads 3. prepare double-stranded cDNA 4. check quality of

A Comparative Evaluation of Videodiscs for General Biology.

ERIC Educational Resources Information Center

Ralph, Charles L.

1995-01-01

Provides a brief profile of the currently available videodiscs for general biology, with comparable information for each. An introduction discusses benefits and problems associated with videodisc use in the classroom. Profiles contain information on description, good and bad features, still images, animations and movies, audio, software,…

Business Information Systems. Occupational Competency Analysis Profile.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Vocational Instructional Materials Lab.

This Occupational Competency Analysis Profile (OCAP) for business information systems is an employer-verified competency list that evolved from a modified DACUM (Developing a Curriculum) job analysis process involving business, industry, labor, and community agency representatives throughout Ohio. The competency list consists of 10 units: (1) data…

Numerical Model Metrics Tools in Support of Navy Operations

NASA Astrophysics Data System (ADS)

Dykes, J. D.; Fanguy, P.

2017-12-01

Increasing demands of accurate ocean forecasts that are relevant to the Navy mission decision makers demand tools that quickly provide relevant numerical model metrics to the forecasters. Increasing modelling capabilities with ever-higher resolution domains including coupled and ensemble systems as well as the increasing volume of observations and other data sources to which to compare the model output requires more tools for the forecaster to enable doing more with less. These data can be appropriately handled in a geographic information system (GIS) fused together to provide useful information and analyses, and ultimately a better understanding how the pertinent model performs based on ground truth.. Oceanographic measurements like surface elevation, profiles of temperature and salinity, and wave height can all be incorporated into a set of layers correlated to geographic information such as bathymetry and topography. In addition, an automated system that runs concurrently with the models on high performance machines matches routinely available observations to modelled values to form a database of matchups with which statistics can be calculated and displayed, to facilitate validation of forecast state and derived variables. ArcMAP, developed by Environmental Systems Research Institute, is a GIS application used by the Naval Research Laboratory (NRL) and naval operational meteorological and oceanographic centers to analyse the environment in support of a range of Navy missions. For example, acoustic propagation in the ocean is described with a three-dimensional analysis of sound speed that depends on profiles of temperature, pressure and salinity predicted by the Navy Coastal Ocean Model. The data and model output must include geo-referencing information suitable for accurately placing the data within the ArcMAP framework. NRL has developed tools that facilitate merging these geophysical data and their analyses, including intercomparisons between model predictions as well as comparison to validation data. This methodology produces new insights and facilitates identification of potential problems in ocean prediction.