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Sample records for profile terry young

  1. Solute transport in formations of very low permeability: profiles of stable isotope and dissolved noble gas contents of pore water in the Opalinus Clay, Mont Terri, Switzerland

    NASA Astrophysics Data System (ADS)

    Rübel, André P.; Sonntag, Christian; Lippmann, Johanna; Pearson, F. J.; Gautschi, Andreas

    2002-04-01

    Pore water profiles of water, stable isotope, and dissolved noble gas content have been determined across the Opalinus Clay and adjacent formations at the rock laboratory at Mont Terri. We have found enhanced helium contents (up to [ 4He] = 1 × 10 -4 cubic centimeters at standard pressure and temperature per gram of pore water) and argon isotope ratios ( 40Ar/ 36Ar ratios up to 334) due to accumulation of 4He and 40Ar produced in situ. The helium profile was found to be in steady state with respect to in situ production and diffusive loss into the adjacent limestones where groundwater circulates. From this profile a representative mean value of the apparent diffusion coefficient for helium in the pore water of the whole formation was derived for the first time to be D a = 3.5 × 10 -11 m 2 · s -1, which is more than two orders of magnitude lower than the diffusion coefficient D 0 in free water. The stable isotope profile, however, indicates a component of fossil marine pore water, which has not yet been replaced by molecular diffusion of meteoric water from the adjacent limestone and shale formations over the past 10 million years.

  2. Portrait view of Terry White

    NASA Image and Video Library

    1983-04-10

    Terry White during a change-of-shift briefing in the JSC public affairs facility briefing room. White acted as one of the on-orbit public affairs officers and the landing PAO during the Challenger's STS-6 flight.

  3. Megan Terry's Plays for Youth at the Omaha Magic Theatre.

    ERIC Educational Resources Information Center

    Klein, Jeanne

    Nebraska's Omaha Magic Theatre (OMT) and playwright Megan Terry are concerned with producing socially relevant, issue-oriented musical plays, focusing on young people and the adults who influence their emotional lives. OMT's "Theatre of Process" focuses upon the performing artist to develop and test ways to make theater more meaningful,…

  4. Teaching Terry McMillan's Short Fiction.

    ERIC Educational Resources Information Center

    Volz, Sabrina

    2001-01-01

    Analyzes author Terry McMillan's conception of aesethics and offers practical suggestions for the teaching of "Ma Dear" and "Quilting on the Rebound" to English-as-a-foreign-language students at the postsecondary level. (Author/VWL)

  5. Terry Quist Discusses Skylab Experiment

    NASA Technical Reports Server (NTRS)

    1972-01-01

    San Antonio, Texas high school student, Terry C. Quist (left), and Dr. Raymond Gause of the Marshall Space Flight Center (MSFC), discuss the student's experiment to be performed aboard the Skylab the following year. His experiment, 'Earth Orbital Neutron Analysis' required detectors such as the one he is examining in this photo. The detector was to be attached to a water tank in Skylab. Neutrons striking the detectors left traces that were brought out by a chemical etching process after the Skylab mission. Quist's experiment seeked to record neutron hits, count them, and determine their direction. This information was to help determine the source of neutrons in the solar system. Quist was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  6. Terri Schiavo: A Disability Rights Case

    ERIC Educational Resources Information Center

    Johnson, Mary

    2006-01-01

    The author argues that Terri Schiavo was a "person with a disability" who faced disability discrimination, a view that is consistent with national disability rights groups. The author notes that Schiavo was not "terminally ill" and that feeding tubes should not be considered "medical equipment." The belief that people with severe disabilities want…

  7. Influencing collaborative leadership: an interview with Dean Terry Fulmer. Interview by Jeffrey M. Adams.

    PubMed

    Fulmer, Terry

    2013-02-01

    This department highlights nursing leaders who have demonstrated a commitment to innovation and patient care leadership in practice, policy, research, education and theory. This interview profiles Terry Fulmer, PhD, RN, FAAN, chairperson of the Robert Wood Johnson Executive Nurse Fellows Advisory Committee and dean of the Bouvé College of Health Sciences at Northeastern University.

  8. Physical Profiles of Turkish Young Greco-Roman Wrestlers

    ERIC Educational Resources Information Center

    Arslanoglu, Erkal

    2015-01-01

    The aim of this study is to evaluate some physical properties of Turkish National Greco-Roman wrestlers and reveal the profile of Turkish Young National Greco-Roman athlete. A total of 48 male athletes who were from Turkish Young National Greco-Roman Wrestling Team participated in this study. This study was carried out at Wrestling Federation…

  9. Physical Profiles of Turkish Young Greco-Roman Wrestlers

    ERIC Educational Resources Information Center

    Arslanoglu, Erkal

    2015-01-01

    The aim of this study is to evaluate some physical properties of Turkish National Greco-Roman wrestlers and reveal the profile of Turkish Young National Greco-Roman athlete. A total of 48 male athletes who were from Turkish Young National Greco-Roman Wrestling Team participated in this study. This study was carried out at Wrestling Federation…

  10. ISS Update: SPHERES with Telerobotics Project Manager Terry Fong

    NASA Image and Video Library

    NASA Public Affairs Officer Brandi Dean talks with Terry Fong, Telerobotics Project Manager, about how the Synchronized Position, Hold, Engage and Reorient Experimental Satellites, or SPHERES, are ...

  11. Personality Profiles of Physically Impaired Young Adults.

    ERIC Educational Resources Information Center

    Richman, Lynn C.; Harper, Dennis C.

    1980-01-01

    Different forms of chronic observable disability may have differing impacts on adult personality adjustment. Young adults with cleft lip/palate display fewer personality adjustment problems than those with orthopedic impairment. (Author)

  12. Personality Profiles of Physically Impaired Young Adults.

    ERIC Educational Resources Information Center

    Richman, Lynn C.; Harper, Dennis C.

    1980-01-01

    Different forms of chronic observable disability may have differing impacts on adult personality adjustment. Young adults with cleft lip/palate display fewer personality adjustment problems than those with orthopedic impairment. (Author)

  13. Personality Profiles and Frequent Heavy Drinking in Young Adulthood.

    PubMed

    Zhang, Jieting; Bray, Bethany C; Zhang, Minqiang; Lanza, Stephanie T

    2015-07-01

    Few studies examining the link between personality and alcohol use have adopted a comprehensive modeling framework to take into account individuals' profiles across multiple personality traits. In this study, latent profile analysis (LPA) was applied to a national sample of young adults in the United States to identify subgroups defined by their profiles of mean scores on the Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness personality factors. Personality profiles were then used to predict heavy drinking. Five profiles were identified: Reserved, Rigid, Confident, Ordinary, and Resilient. Compared to individuals in the Ordinary profile, those with Reserved and Resilient profiles were at increased risk of frequent heavy drinking. These findings suggest which comprehensive personality profiles may place individuals at risk for problematic alcohol-related outcomes.

  14. Personality Profiles and Frequent Heavy Drinking in Young Adulthood

    PubMed Central

    Bray, Bethany C.; Zhang, Minqiang; Lanza, Stephanie T.

    2015-01-01

    Few studies examining the link between personality and alcohol use have adopted a comprehensive modeling framework to take into account individuals’ profiles across multiple personality traits. In this study, latent profile analysis (LPA) was applied to a national sample of young adults in the United States to identify subgroups defined by their profiles of mean scores on the Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness personality factors. Personality profiles were then used to predict heavy drinking. Five profiles were identified: Reserved, Rigid, Confident, Ordinary, and Resilient. Compared to individuals in the Ordinary profile, those with Reserved and Resilient profiles were at increased risk of frequent heavy drinking. These findings suggest which comprehensive personality profiles may place individuals at risk for problematic alcohol-related outcomes. PMID:25892836

  15. Young addicted men hormone profile detection

    NASA Astrophysics Data System (ADS)

    Zieliński, Paweł; Wasiewicz, Piotr; Leszczyńska, Bożena; Gromadzka-Ostrowska, Joanna

    2010-09-01

    Hormone parameters were determined in the serum of young addicted men in order to compare them with those obtained from the group of healthy subjects. Three groups were investigated which were named opiates, mixed and control group. Statistical and data mining methods were applied to obtain significant differences. R package was used for all computation. The determination of hormones parameters provide important information relative to impact of addiction.

  16. Examining young children's social competence using functional ability profiles.

    PubMed

    McLaughlin, Tara W; Snyder, Patricia A; Algina, James

    2017-08-13

    To explore the use of International Classification of Functioning, Disability, and Health for Children and Youth (ICF-CY) based profiles of children's functional abilities in relation to their social competence. Subgroups based on shared profiles of functional ability were investigated as an alternative or complement to subgroups defined by disability categories. Secondary analysis of a nationally representative data set of young children identified for special education services in the United States was used for the present study. Using five subgroups of children with shared profiles of functional ability, derived from latent class analysis in previous work, regression analyses were used to examine the relationships between social competence and functional abilities profile subgroup membership. Differences among the subgroups were examined using standardized effect sizes. R(2) values were used to examine explained variance in social competence in relation to subgroup membership, disability category, and these variables in combination. Functional ability profile subgroup membership was moderately related to children's social competence outcomes: social skills and problem behaviors. Effect sizes showed significant differences between subgroups. Subgroup membership accounted for more variance in social competence outcomes than disability category. The results provide empirical support for the importance of functional ability profiles when examining social competence within a population of young children with disabilities. Implications for Rehabilitation The extent to which children with disabilities experience difficulty with social competence varies by their functional characteristics. Functional ability profiles can provide practitioners and researchers working young children with disabilities important tools to examine social competence and to inform interventions.

  17. Physical profile of elite young motorcyclists.

    PubMed

    Sánchez-Muñoz, C; Rodríguez, M A; Casimiro-Andújar, A J; Ortega, F B; Mateo-March, M; Zabala, M

    2011-10-01

    The aim of the study was to describe anthropometric and physical characteristics of elite young road-race motorcyclists (MC). 27 riders (15.6±1.1 years, 54.6±6.9 kg, 166.9±6.7 cm) competing at international elite level participated in this study. Anthropometric variables, hand grip and lumbar isometric strength, and lower-body muscular strength were measured. Comparisons of the MC and a reference group of Spanish physically active adolescents (16.0±0.6 years) showed that the riders were significantly lighter (-12.5 kg), and smaller (-4.7 cm). Riders also had significantly lower values for almost all skinfolds, and for all the measured girths (except forearm) than the reference group. Motorcyclists showed significantly less percent body fat (%BF) and higher muscle mass, and differences were observed for somatotype components compared to the reference group, except for the ectomorphy. Somatotype could be defined as mesomorphic-ectomorph (2.5-4.4-3.7). Mean (±SD) values of all riders were 34.8±5.0 cm for vertical jump height, 402.1±74.5 N for the right hand and 370.7±77.5 N for the left hand strengths, and 120.6±19.3 kg for lumbar isometric strength, respectively. Results demonstrate that MC are small and light, with lower body mass index, skinfolds, girth and breadth dimensions, and %BF than a reference group and other athletes, with high values of hand grip and lumbar isometric strength. © Georg Thieme Verlag KG Stuttgart · New York.

  18. Astronaut Terry Hart in orbiter training in the SAIL

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Terry J. Hart, 41-C mission specialist, 'punches up' a display in an orbiter trainer in the JSC Shuttle Avionics Integration Laboratory (SAIL). The scenes Hart controls here appear in the 'windows' of the trainer.

  19. The Terri Schiavo case: legal, ethical, and medical perspectives.

    PubMed

    Perry, Joshua E; Churchill, Larry R; Kirshner, Howard S

    2005-11-15

    Although tragic, the plight of Terri Schiavo provides a valuable case study. The conflicts and misunderstandings surrounding her situation offer important lessons in medicine, law, and ethics. Despite media saturation and intense public interest, widespread confusion lingers regarding the diagnosis of persistent vegetative state, the judicial processes involved, and the appropriateness of the ethical framework used by those entrusted with Terri Schiavo's care. First, the authors review the current medical understanding of persistent vegetative state, including the requirements for patient examination, the differential diagnosis, and the practice guidelines of the American Academy of Neurology regarding artificial nutrition and hydration for patients with this diagnosis. Second, they examine the legal history, including the 2000 trial, the 2002 evidentiary hearing, and the subsequent appeals. The authors argue that the law did not fail Terri Schiavo, but produced the highest-quality evidence and provided the most judicial review of any end-of-life guardianship case in U.S. history. Third, they review alternative ethical frameworks for understanding the Terri Schiavo case and contend that the principle of respect for autonomy is paramount in this case and in similar cases. Far from being unusual, the manner in which Terri Schiavo's case was reviewed and the basis for the decision reflect a broad medical, legal, and ethical consensus. Greater clarity regarding the persistent vegetative state, less apprehension of the presumed mysteries of legal proceedings, and greater appreciation of the ethical principles at work are the chief benefits obtained from studying this provocative case.

  20. Young children with fetal alcohol spectrum disorder--communication profiles.

    PubMed

    de Beer, Mari; Kritzinger, Alta; Zsilavecz, Ursula

    2010-12-01

    The aim of the article is to describe the communication profiles of five young children with fetal alcohol spectrum disorder (FASD) from 4 to 58 months of age. A collective case-study design following a quantitative and descriptive approach was used to describe the communication profiles of the participants. The results are described according to the participants' case histories and a four-level early communication assessment framework. The significant findings were that all participants were in foster care, and presented with incomplete case histories, general developmental delays and delays regarding all aspects of their communication abilities. An increase in the severity of the spectrum disorder across the participants' combined communication profiles was also identified. Participants presented with complex multiple neurodevelopmental needs that should be viewed within a developmental systems and ecological framework. The importance of early identification, diagnosis and assessment of infants and young children prenatally exposed to alcohol, the identification of precursors to communication impairment at a very early age, and the need for individualised early communication intervention to improve developmental outcomes within a family-centred approach are discussed. Suggestions for future research to accumulate knowledge about FASD in the field of early communication intervention are made.

  1. Contextual profiles of young adult Ecstasy users: a multisite study

    PubMed Central

    Ramtekkar, Ujjwal P.; Striley, Catherine W; Cottler, Linda B

    2010-01-01

    These analyses assess contextual profiles of 612 young adult Ecstasy users, 18–30 years of age, from St. Louis (USA), Miami (USA) and Sydney (Australia). Bivariate analyses revealed different contextual factors influencing Ecstasy use. Friends were the most common sources of Ecstasy at all sites and most used with friends. St. Louis and Miami use mostly occurred in residences, whereas in Sydney use was mostly at clubs, bars or restaurants. Ecstasy consumption at public places and in cars, trains or ferries was significantly higher in Miami (89% and 77%) than in St. Louis (67% and 65%) and Sydney (67% and 61%). At all sites, simultaneous use of LSD/mushroom and nitrous oxide with Ecstasy was common; concurrent amphetamines predominated in Sydney and heroin/opiates in St. Louis Contextual factors influencing Ecstasy use among young adults vary by geographic region. Their inclusion may help tailor effective prevention programs to reduce or ameliorate Ecstasy use. PMID:21094585

  2. Research in the Mont Terri Rock laboratory: Quo vadis?

    NASA Astrophysics Data System (ADS)

    Bossart, Paul; Thury, Marc

    During the past 10 years, the 12 Mont Terri partner organisations ANDRA, BGR, CRIEPI, ENRESA, FOWG (now SWISSTOPO), GRS, HSK, IRSN, JAEA, NAGRA, OBAYASHI and SCK-CEN have jointly carried out and financed a research programme in the Mont Terri Rock Laboratory. An important strategic question for the Mont Terri project is what type of new experiments should be carried out in the future. This question has been discussed among partner delegates, authorities, scientists, principal investigators and experiment delegates. All experiments at Mont Terri - past, ongoing and future - can be assigned to the following three categories: (1) process and mechanism understanding in undisturbed argillaceous formations, (2) experiments related to excavation- and repository-induced perturbations and (3) experiments related to repository performance during the operational and post-closure phases. In each of these three areas, there are still open questions and hence potential experiments to be carried out in the future. A selection of key issues and questions which have not, or have only partly been addressed so far and in which the project partners, but also the safety authorities and other research organisations may be interested, are presented in the following. The Mont Terri Rock Laboratory is positioned as a generic rock laboratory, where research and development is key: mainly developing methods for site characterisation of argillaceous formations, process understanding and demonstration of safety. Due to geological constraints, there will never be a site specific rock laboratory at Mont Terri. The added value for the 12 partners in terms of future experiments is threefold: (1) the Mont Terri project provides an international scientific platform of high reputation for research on radioactive waste disposal (= state-of-the-art research in argillaceous materials); (2) errors are explicitly allowed (= rock laboratory as a “playground” where experience is often gained through

  3. Discriminant profile of young adulthood driving behavior among Brazilian drivers.

    PubMed

    Dotta-Panichi, Renata Maria; Wagner, Adriana; Sarriera, Jorge Castellá

    2013-01-01

    The aim of this article was to describe the driving behavior profile of drivers aged 18 to 25 years old. Four hundred young adults were interviewed, 320 (80%) of them male and 80 (20%) female. Cluster analysis identified a group characterized by sensation-seeking behavior (Cluster 1), a group that did not show any risky driving behavior (Cluster 2), and a group engaged in transgressive behavior and driving under the influence of alcohol and/or drugs (Cluster 3). Discriminant analysis classified successfully and correctly 81.3% of the young adults into their original profiles. Function 1 distinguished cluster 1 from clusters 2 and 3, on the basis of the following factors: higher frequency of alcohol consumption, intrusive behavior, and motorcycle riding, as well as younger age, more aggressive behavior, and lower education level. Function 2 distinguished cluster 3 from cluster 1 and 2, especially as to higher amounts of alcohol consumption, higher frequency of marijuana use and delinquent behavior, larger number of traffic tickets and motor vehicle accidents, higher paternal education level, which were the variables with discriminant values above .20. Characteristics of vulnerability were identified, especially those related to alcohol consumption, drug use, and externalizing issues.

  4. A Medical Ethics Assessment of the Case of Terri Schiavo

    ERIC Educational Resources Information Center

    Preston, Tom; Kelly, Michael

    2006-01-01

    The social, legal, and political discussion about the decision to stop feeding and hydration for Terri Schiavo lacked a medical ethics assessment. The authors used the principles of medical indications, quality of life, patient preference, and contextual features as a guide to medical decision-making in this case. Their conclusions include the…

  5. B. F. Terry High School: Commitment Makes It Happen

    ERIC Educational Resources Information Center

    Principal Leadership, 2011

    2011-01-01

    The change in academic achievement at B. F. Terry High School in Rosenberg, Texas, over the last four years is proudly displayed on the outside of the building with the sign that proclaims it a Texas School of Distinction, but it's the change in attitude inside of the school that's most striking. A growing majority of the school's students live in…

  6. The Whiz Kid: Terry Reese--Oregon State University

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    We should be grateful that Terry Reese had to work his way through college. As a work-study student, taught to do cartographic cataloging in the University, of Oregon's map library, he discovered the mental challenges libraries offered. Later he became Oregon State University (OSU)'s cataloger for networked resources and digital unit production…

  7. 26. Photocopy of photograph taken by W. Terry Averbeck, date ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photocopy of photograph taken by W. Terry Averbeck, date unknown. VIEW, LOOKING NORTHWEST, OF SECOND STREET BETWEEN SCOTT AND COURT STREETS, SHOWING PORTIONS OF THE ICE STORAGE BUILDING AND ORIGINAL SHIPPING AREA, NOW USED AS BAGGING/CRUSHING AREA (8x10' enlargement from 4x5' negative) - Champion Ice Manufacturing & Cold Storage Company, 40 East Second Street, Covington, Kenton County, KY

  8. A Medical Ethics Assessment of the Case of Terri Schiavo

    ERIC Educational Resources Information Center

    Preston, Tom; Kelly, Michael

    2006-01-01

    The social, legal, and political discussion about the decision to stop feeding and hydration for Terri Schiavo lacked a medical ethics assessment. The authors used the principles of medical indications, quality of life, patient preference, and contextual features as a guide to medical decision-making in this case. Their conclusions include the…

  9. B. F. Terry High School: Commitment Makes It Happen

    ERIC Educational Resources Information Center

    Principal Leadership, 2011

    2011-01-01

    The change in academic achievement at B. F. Terry High School in Rosenberg, Texas, over the last four years is proudly displayed on the outside of the building with the sign that proclaims it a Texas School of Distinction, but it's the change in attitude inside of the school that's most striking. A growing majority of the school's students live in…

  10. 2016 Summer Series - Terry Fong - Planetary Exploration Reinvented

    NASA Image and Video Library

    2016-07-07

    The allure of deep space drives humanity’s curiosity to further explore the universe, but the risks associated with spaceflight are still limiting. Technological advancements in robotics and data processing are pushing the envelope of Human planetary exploration and habitation. Dr. Terry Fong from the NASA Ames’ Intelligent Robotics Group will describe how we are reinventing the approach to explore the universe.

  11. Teaching Literature as Dialogue: Coming to Terms with Terry Eagleton.

    ERIC Educational Resources Information Center

    Madden, Thomas R.

    The literary theorist Terry Eagleton believes that literary study is the study of human discourse. To build on his idea for use in the classroom, it must first be assumed that literature constitutes a dialogue between the work (and its author) and the reader. The dialogue process can be introduced in a 2- to 4-week unit through a cluster of…

  12. Temperament profiles in personality disorders among a young adult population.

    PubMed

    Kantojärvi, Liisa; Miettunen, Jouko; Veijola, Juha; Läksy, Kristian; Karvonen, Juha T; Ekelund, Jesper; Järvelin, Marjo-Riitta; Lichtermann, Dirk; Joukamaa, Matti

    2008-01-01

    The objective of this study was to describe the temperament dimension profiles assessed by the Temperament and Character Inventory (TCI) among young adults with the DSM-III-R personality disorder (PD). Our hypothesis was that PD clusters and separate PDs can be distinguished from one another by their specific temperament profiles. As a part of the 31-year follow-up survey of the prospective Northern Finland 1966 Birth Cohort, the cohort members living in the city of Oulu at the age of 31 years (n=1609) were invited to participate in a two-phase field study. The Structured Clinical Interview for DSM-III-R for PDs (SCID-II) was used as diagnostic instrument. The final study sample consisted of the 1311 subjects who had completed the Hopkins Symptom Check List-25 questionnaire for screening and had given a written informed consent. Of the 321 SCID interviewed subjects, 74 met the criteria for at least one PD and had completed the TCI. The mean TCI scores of subjects with PD and control subjects without PD (n=910) were compared. Low Novelty Seeking, high Harm Avoidance and low Reward Dependence characterized cluster A and C PDs. Subjects with a cluster B PD did not differ from controls, except for Novelty Seeking, which was high. The temperament dimensions could not distinguish different PDs very well, with the only exception of persons with obsessive-compulsive PD. PD clusters were associated with different profiles of temperament, lending some support for Cloninger's typology.

  13. Anthropometric characteristics and nutritional profile of young amateur swimmers.

    PubMed

    Martínez, Sonia; Pasquarelli, Bruno N; Romaguera, Dora; Arasa, Cati; Tauler, Pedro; Aguiló, Antoni

    2011-04-01

    The aim of this study was to evaluate nutritional and anthropometric profiles of young swimmers belonging to semiprofessional teams. Thirty-six caucasian adolescent swimmers (22 boys and 14 girls) participated voluntarily in the study. Anthropometric data, dietary intake, and blood parameters were determined. Female swimmers had greater values of triceps, suprailiac, and abdominal skinfolds. Endomorphic somatotype was twofold greater in girls compared with in boys. Energy intake and protein intake per kilogram of body weight were significantly greater in boys compared to in girls. On the other hand, girls had significantly greater polyunsaturated fatty acid intake compared that of boys. Energy intake of boys and girls was below their requirements. In contrast, protein intake doubled the requirements of the study population. Furthermore, inadequate intake of carotenes, vitamin A, vitamin E, vitamin D, and folic acid was found in both boys and girls; girls also had inadequate intake of iron and calcium. Plasma levels of iron, vitamins C and E, and carotenes were similar in male and females swimmers, and they were within the normal range. In conclusion, young swimmers participating in the present study had differences between sexes in somatotypes. Adolescent swimmers had low average total energy intakes, excessive protein intake, and lower intake of several micronutrients in both sexes.

  14. Hydrodynamic profile of young swimmers: changes over a competitive season.

    PubMed

    Barbosa, T M; Morais, J E; Marques, M C; Silva, A J; Marinho, D A; Kee, Y H

    2015-04-01

    The aim of this study was to analyze the changes in the hydrodynamic profile of young swimmers over a competitive season and to compare the variations according to a well-designed training periodization. Twenty-five swimmers (13 boys and 12 girls) were evaluated in (a) October (M1); (b) March (M2); and (c) June (M3). Inertial and anthropometrical measures included body mass, swimmer's added water mass, height, and trunk transverse surface area. Swimming efficiency was estimated by the speed fluctuation, stroke index, and approximate entropy. Active drag was estimated with the velocity perturbation method and the passive drag with the gliding decay method. Hydrodynamic dimensionless numbers (Froude and Reynolds numbers) and hull velocity (i.e., speed at Froude number = 0.42) were also calculated. No variable presented a significant gender effect. Anthropometrics and inertial parameters plus dimensionless numbers increased over time. Swimming efficiency improved between M1 and M3. There was a trend for both passive and active drag increase from M1 to M2, but being lower at M3 than at M1. Intra-individual changes between evaluation moments suggest high between- and within-subject variations. Therefore, hydrodynamic changes over a season occur in a non-linear fashion way, where the interplay between growth and training periodization explain the unique path flow selected by each young swimmer. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Biography Today: Profiles of People of Interest to Young Readers, 2000.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    2000-01-01

    This is the ninth volume of a series designed and written for young readers ages 9 and above. It contains three issues and profiles individuals whom young people want to know about most: entertainers, athletes, writers, illustrators, cartoonists, and political leaders. The publication was created to appeal to young readers in a format they can…

  16. Activity profile of young soccer players during actual match play.

    PubMed

    Castagna, Carlo; D'Ottavio, Stefano; Abt, Grant

    2003-11-01

    This study investigated the activity profile of young soccer players (mean age 11.8 +/- 0.6 years; N = 12) with the aim of providing information for the development of training strategies. Data for movements of each player were obtained using 2 cameras that aimed at the subject throughout the match (Play Controller, Phromos, Italy). Encoders transmitted camera movements to a computer. The collected signals were then converted into distances, times, and speed attained at arbitrarily selected match categories. Players were monitored during official 11 vs. 11 matches (N = 12), with each match consisting of 2 halves, each lasting 30 minutes played on a regular soccer pitch. Mean total match distance amounted to 6,175 +/- 318 m. During the second half, players covered 5.5% less distance (p > 0.05). At speeds between 13.1 and 18.0 km.h(-1), players covered 12% less distance during the second half (p < 0.05). Players stood still 11% of the total time played (3,789 +/- 109 seconds). At speeds faster than 18 km.h(-1), players performed 33 +/- 4 bouts during match play, with a mean time length of 2.3 +/- 0.6 seconds per bout. Mean time interval between two successive maximal sprint bouts was 118.5 +/- 20.5 seconds. Players stood still longer during the course of the second half (229 +/- 76 seconds vs. 173 +/- 61 seconds, p < 0.05). Players tended to play in small areas of the football pitch and spent 9% of the total match time at high intensity. In order to promote a more active space coverage of the young player, at least for the age considered in the present study, the dimensions of the football pitch and the number of players should be reduced.

  17. [Cytokine profile in young children with acute stenotic laryngotracheitis].

    PubMed

    Гладченко, Ольга І; Токарєв, Павло В; Надрага, Олександр Б

    2016-01-01

    One of the most severe complications of acute respiratory infections in young children is acute stenotic laryngotracheitis (croup). The relationship between cytokine blood levels and symptoms of croup, croup severity, disease sequel, despite numerous studies is still unclear. Cytokine profile in young children with acute stenotic laryngotracheitis investigation. 112 children aged 12 min. - 36 mon. with acute stenotic laryngotracheitis which were treated at the Lviv Regional Infectious Diseases Hospital were kept under observation. Croup symptoms, levels of interleukins (IL1, IL4, IL6, IL10, IL17) in serum, DNA and RNA viruses in respiratory nasal mucus were studied; Chan croup severity was used. In the pathogenesis of croup has an important role the imbalance between inflammatory (IL1, IL6) and anti-inflammatory (IL4, IL10, IL17) cytokines, which does not reduce the intensity of inflammatory reactions and its lead to local swelling, muscle spasm, excessive production of mucus in the place of viral replication. The levels of inflammatory and anti-inflammatory cytokines in the blood serum of children with croup were significantly higher than in patients with acute laryngitis. In patients with recurrent croup, unlike patients with the first case of croup does we don't see a significant correlation between the concentrations of inflammatory and anti-inflammatory cytokine levels Conclusions: The significantly higher levels of cytokines in children with croup compared with the group of patients with acute laryngitis were found, imbalance between anti-inflammatory (IL1, IL6) cytokine levels and inflammatory (IL4, IL10, IL17) cytokine levels in children who developed recurrent croup.

  18. Cardiovascular risk profile of young adults: changes over time.

    PubMed

    Tralhão, António; Sousa, Pedro Jerónimo; Ferreira, António Miguel; Miranda, Mafalda; Monge, José Carlos; Tomé, António; Duarte, José Maria

    2014-03-01

    The high prevalence and natural history of atherosclerosis make young people important targets for cardiovascular prevention. This study aimed to analyze changes over time in the cardiovascular risk profile of a population of healthy young adults. We studied 923 Portuguese Air Force applicants between 1991 and 2007, divided into two-year periods. In addition to cardiovascular risk factors, the Framingham score and HeartScore were calculated for age 65. Cochran-Armitage and Jonckheere-Terpstra tests for trend were used for categorical and continuous variables, respectively. Mean age was 19.2 ± 2.3 years (p = 0.34) and 55 applicants (6%) were female (p = 0.56). Mean body mass index was 22.4 ± 2.5 kg (p for trend 0.35). The number of smokers decreased over the study period (11.6 vs. 7.0%, p for trend 0.02). Of the total number of applicants, 122 (13.2%) were classified as hypertensive. Mean systolic blood pressure was 127 ± 12 mmHg and increased significantly over time (122 ± 13 vs. 128 ± 11 mmHg, p for trend <0.001). Hypercholesterolemia was found in 108 applicants (11.7%) and total cholesterol showed an improvement (170 ± 35 vs. 155 ± 26 mg/dl, p for trend <0.001). The mean modified Framingham score was 12.6 ± 5.1 and improved over the study period (12.9 ± 5.9% vs. 11.9 ± 4.7%, p for trend 0.006). The mean modified HeartScore was 3.2 ± 1.4 and remained unchanged (p for trend 0.10). In our population, except for an increase in systolic blood pressure values, there was an overall improvement in cardiovascular risk from 1991 to 2007. Further studies are needed to better assess the situation in Portugal and help devise preventive strategies in young people. Copyright © 2013 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

  19. SINGLE PHASE ANALYTICAL MODELS FOR TERRY TURBINE NOZZLE

    SciTech Connect

    Zhao, Haihua; Zhang, Hongbin; Zou, Ling; O'Brien, James

    2016-11-01

    All BWR RCIC (Reactor Core Isolation Cooling) systems and PWR AFW (Auxiliary Feed Water) systems use Terry turbine, which is composed of the wheel with turbine buckets and several groups of fixed nozzles and reversing chambers inside the turbine casing. The inlet steam is accelerated through the turbine nozzle and impacts on the wheel buckets, generating work to drive the RCIC pump. As part of the efforts to understand the unexpected “self-regulating” mode of the RCIC systems in Fukushima accidents and extend BWR RCIC and PWR AFW operational range and flexibility, mechanistic models for the Terry turbine, based on Sandia National Laboratories’ original work, has been developed and implemented in the RELAP-7 code to simulate the RCIC system. RELAP-7 is a new reactor system code currently under development with the funding support from U.S. Department of Energy. The RELAP-7 code is a fully implicit code and the preconditioned Jacobian-free Newton-Krylov (JFNK) method is used to solve the discretized nonlinear system. This paper presents a set of analytical models for simulating the flow through the Terry turbine nozzles when inlet fluid is pure steam. The implementation of the models into RELAP-7 will be briefly discussed. In the Sandia model, the turbine bucket inlet velocity is provided according to a reduced-order model, which was obtained from a large number of CFD simulations. In this work, we propose an alternative method, using an under-expanded jet model to obtain the velocity and thermodynamic conditions for the turbine bucket inlet. The models include both adiabatic expansion process inside the nozzle and free expansion process out of the nozzle to reach the ambient pressure. The combined models are able to predict the steam mass flow rate and supersonic velocity to the Terry turbine bucket entrance, which are the necessary input conditions for the Terry Turbine rotor model. The nozzle analytical models were validated with experimental data and

  20. Nutritional status and lipid profile of young children in Brazil.

    PubMed

    Pereira, Joilane Alves; Rondó, Patricia Helen Carvalho; Lemos, Jesuana Oliveira; de Oliveira, Ellaine; Rocha, Cinthya; Hipólito, Thiago

    2013-02-01

    To evaluate the nutritional status and lipid profile of young children from an urban Brazilian region. Cross-sectional study involving a representative sample of 472 children aged 5-8 years from Jundiai city. The nutritional status was assessed by the body mass index for age. Total cholesterol and fractions (low-density lipoprotein cholesterol, high density lipoprotein cholesterol) and triglycerides concentrations were determined by automated enzymatic methods. The results were analyzed by the student t-test and Fisher exact test. Overweight/obesity was observed in 22% of the children and thinness in 3.2%. Girls presented a higher prevalence of overweight/obesity (24.0%) and lower levels of high-density lipoprotein cholesterol (22.8%) compared with boys (19.7% and 10.6%), respectively (p < 0.001). The prevalence of children with elevated and borderline total cholesterol was 32.8% and 26.7%, respectively, although 82.8% had desirable levels of high-density lipoprotein cholesterol. The prevalence of overweight/obesity and dyslipidaemia observed in these children is a matter of concern considering the age group evaluated.

  1. African American parents' racial and emotion socialization profiles and young adults' emotional adaptation.

    PubMed

    Dunbar, Angel S; Perry, Nicole B; Cavanaugh, Alyson M; Leerkes, Esther M

    2015-07-01

    The current study aimed to identify parents' profiles of racial and emotion socialization practices, to determine if these profiles vary as a function of family income and young adult child gender, and to examine their links with young adults' emotional adaptation. Participants included 192 African American young adults (70% women) who ranged in age from 18 to 24 years (M = 19.44 years). Four maternal profiles emerged: cultural-supportive (high cultural socialization and supportive responses to children's negative emotions), moderate bias preparation (moderate preparation for bias, promotion of mistrust, and nonsupportive responses to negative emotions), high bias preparation (high preparation for bias, promotion of mistrust, and nonsupportive responses), and low engaged (low across racial and socialization constructs). Three paternal profiles emerged: multifaceted (moderate across racial and emotion socialization constructs), high bias preparation, and low engaged. Men were more likely to have mothers in the high bias preparation and to have fathers in the multifaceted or high bias preparation profiles. Individuals with higher income were more likely to have mothers in the cultural-supportive profile and to have fathers in the multifaceted profile. Young adults whose mothers fit the cultural-supportive profile or the moderate bias preparation profile had lower levels of depressive symptoms than young adults whose mothers fit the high bias preparation profile.

  2. Dark shadows of rumination: Finnish young adults' identity profiles, personal goals and concerns.

    PubMed

    Marttinen, Elina; Dietrich, Julia; Salmela-Aro, Katariina

    2016-02-01

    Young adults actively construct their identity by exploring and committing to opportunities through the setting of personal goals. Typically personal goal contents are related to young adults' developmental tasks but sometimes goals are self-focused. This longitudinal study explored personal goal and concern contents in relation to identity profiles among young Finns (N = 577) followed from age 23 to 25. Applying the Dimensions of Identity Development Scale, identity formation was measured at age 23. Latent Profile Analysis yielded five profiles: moderate achievement, moderate diffusion, achievement, diffused diffusion, and reconsidering achievement. Two "dark side" identity profiles, characterized by low commitment and high ruminative exploration, were identified: moderate diffusion and diffused diffusion. The moderate diffusion profile seemed to have developmental task-related personal goals and concerns. In the diffused diffusion profile, self-focused personal goals and concerns were typical and personal goals and concerns towards relationships atypical. These findings persisted over the two-year follow-up.

  3. Inclusive Discourse? Local Media Coverage of the Terri Schiavo Case

    PubMed Central

    Rohlinger, Deana A.; Pederson, JoEllen; Valle, Giuseppina

    2015-01-01

    This article contributes to a more systematic understanding of the role of mainstream media in deliberative processes by analyzing how inclusive local newspapers are of diverse perspectives on the Terri Schiavo case. Using both Pearson’s chi-square test and multinomial logistic regression, we assess how ownership, state political ideology, geographic location, and news format affect what ideas are included in the debate over whether Terri Schiavo’s hydration and nutrition tubes should be removed as well as the tone with which these ideas are discussed. We find that mainstream newspapers are relatively inclusive of diverse ideas and perspectives—regardless of whether the newspaper is independently or corporately owned, the political leanings of the target audience, and the geographic location of the outlet. However, we also find that local newspapers do significantly differ from one another in terms of the frequency and tone with which they include diverse viewpoints. Our research suggests that local outlets downplay ideas that are likely to be regarded as controversial by their target audiences. We conclude with a discussion of the implications of this research for understanding the role of media in deliberative democratic processes in the United States. PMID:26120237

  4. What Would Terri Want? On the Psychological Challenges of Surrogate Decision Making

    ERIC Educational Resources Information Center

    Ditto, Peter H

    2006-01-01

    The Terri Schiavo case was unique in the media attention it garnered, but the decision making challenges faced by Terri's family are common ones encountered by all families who must make choices about the use of life-sustaining medical treatment for an incapacitated loved one. This article highlights three key issues that were particularly…

  5. Biography Today: Profiles of People of Interest to Young Readers, 1992-1993.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.

    1992-01-01

    This publication presents biographical profiles of people of interest to young readers. The concept is unique in that the subjects profiled are not necessarily people of great or lasting stature. Many are noted writers or public figures who have made important contributions to the current world, but a goodly number of entries are biographies of…

  6. Literacy Profiles of At-Risk Young Adults Enrolled in Career and Technical Education

    ERIC Educational Resources Information Center

    Mellard, Daryl F.; Woods, Kari L.; Lee, Jae Hoon

    2016-01-01

    A latent profile analysis of 323 economically and academically at-risk adolescent and young adult learners yielded two classes: an average literacy class (92%) and a low literacy class (8%). The class profiles significantly differed in their word reading and math skills, and in their processing speeds and self-reported learning disabilities. The…

  7. Literacy Profiles of At-Risk Young Adults Enrolled in Career and Technical Education

    ERIC Educational Resources Information Center

    Mellard, Daryl F.; Woods, Kari L.; Lee, Jae Hoon

    2016-01-01

    A latent profile analysis of 323 economically and academically at-risk adolescent and young adult learners yielded two classes: an average literacy class (92%) and a low literacy class (8%). The class profiles significantly differed in their word reading and math skills, and in their processing speeds and self-reported learning disabilities. The…

  8. Biography Today: Profiles of People of Interest to Young Readers, Volume 1, Issue 1, January 1992.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.

    1992-01-01

    This is the first issue of a new quarterly periodical designed to provide young students (9 and above) with biographies/profiles of well-known people in a story-telling format that are more appealing and interesting than those found in more comprehensive and encyclopedic biographical dictionaries. The first issue features profiles of the following…

  9. Blood Biomarker Profile of TBI Associated Cognitive Impairment Among Old and Young Veterans

    DTIC Science & Technology

    2016-10-01

    AWARD NUMBER: W81XWH-14-2-0137 TITLE: Blood Biomarker Profile of TBI- Associated Cognitive Impairment Among Old and Young Veterans PRINCIPAL...DATES COVERED 30Sep2015 - 29Sep2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Blood Biomarker Profile of TBI- Associated Cognitive...project is to define the biomarker profile of TBI- associated cognitive impairment (CI) in veterans and compare it to that of veterans with

  10. Terry Quist Discusses Skylab Experiment With NASA Personnel

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Terry C. Quist (center), high school student from San Antonio, Texas, discusses his proposed Skylab experiment with Marshall Space Flight Center's (MSFC) Henry Floyd (left), coordinator of the Skylab Student Experiment Project, and DR. Raymond Gause, scientific advisor to Quist. The student's experiment, 'Earth Orbital Neutron Analysis', was aimed at learning more about the source of neutrons in the solar system by seeking the number and direction from which each comes. Quist was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment, such as Quist's experiment, which required detector hardware.

  11. Lunar Receiving Laboratory (LRL) - Slezak, Terry - Moon Dust - MSC

    NASA Image and Video Library

    1969-07-25

    The first direct exposure to Lunar material for Crew Reception Personnel probably happened late Friday, 07/25/1969. Terry Slezak (displaying Moon dust on his left hand fingers), MSC photographic technician, was removing film magazines from the first of two (2) containers when the incident occurred. As he removed the plastic seal from Magazine "S", one of the 70mm magazines taken during Apollo XI Extravehicular Activity (EVA), it was apparent that the exterior of the cassette displayed traces of a black powdery substance. Apollo XI Commander Neil Armstrong reported during the mission that he had retrieved a 70mm cassette which had dropped to the Lunar surface. Seen in the backgound is John H. Boynton. ( S69-40054 ) MSC, Houston, TX

  12. Profiles of Vocal Development in Young Cochlear Implant Recipients

    ERIC Educational Resources Information Center

    Ertmer, David J.; Young, Nancy M.; Nathani, Suneeti

    2007-01-01

    Purpose: The main purpose of this investigation was to examine the effects of cochlear implant experience on prelinguistic vocal development in young deaf children. Procedure: A prospective longitudinal research design was used to document the sequence and time course of vocal development in 7 children who were implanted between 10 and 36 months…

  13. Obesity, metabolic profile, and inhibition failure: Young women under scrutiny.

    PubMed

    Catoira, N P; Tapajóz, F; Allegri, R F; Lajfer, J; Rodríguez Cámara, M J; Iturry, M L; Castaño, G O

    2016-04-01

    The prevalence of obesity, as well as evidence about this pathology as a risk factor for cognitive decline and dementia in the elderly, is increasing worldwide. Executive functions have been found to be compromised in most studies, although the specific results are dissimilar. Obese young women constitute an interesting study and intervention group, having been found to be unaffected by age and hormonal negative effects on cognition and considering that their health problems affect not only themselves but their families and offspring. The objective of the present study was to compare the executive performance of obese young women with that of a healthy control group. A cross-sectional study was done among premenopausal women from a public hospital in Buenos Aires. The sample comprised 113 participants (32 healthy controls and 81 obese women), who were evaluated for depressive and anxiety symptoms (Beck Depression Inventory-II and State-Trait Anxiety Inventory) and executive functioning (Trail-Making Test B, Stroop Color and Word Test, Wisconsin Card Sorting Test, and verbal fluency test). Statistical analysis was done by using the SPSS version 20.0 software. Among executive functions, a significant difference was found between groups in inhibition (p<0.01). No correlation was found between psychopathologic measures and Stroop Test Interference results. We found slight correlations between Stroop Test Interference results, waist circumference, fat mass and HDL-cholesterol. In obese group, there was a negative slightly correlation between this cognitive test and 2h post-load glucose level. Inhibition was decreased in our obese young women group, and glucose/lipid metabolism may be involved in this association. The cognitive impairment is comparable with that described in addictive conditions. Our conclusions support the concept of multidisciplinary management of obese patients from the time of diagnosis. Detecting and understanding cognitive dysfunction in this

  14. Pondering the Printz Award. The Michael L. Printz Award for Excellence in Young Adult Literature; The Making of a Printz; The Truth about Trueman: An Interview with Terry Trueman; "Beautiful"..."Fresh"..."Distinguished" Books: Teen Readers Take on the 2002 Printz Awards; Soap Box: A Young Adult Publisher Speaks Out about Winning the Printz Award; Retro Mock Printz: The Best of the Best of Young Adult Literature from the VOYA Years.

    ERIC Educational Resources Information Center

    Butts, Peter; Halls, Kelly Milner; Horne, Claire; Roxburgh, Stephen; Cornish, Sarah; Jones, Patrick

    2002-01-01

    Includes six articles that discuss the Michael L. Printz award for excellence in young adult literature, established by the Young Adult Library Services Association (YALSA) of the American Library Association (ALA). Highlights include a list of winners for the past three years; quality versus popularity; and perspectives from authors, teens, and…

  15. Cognitive Profile in Young Icelandic Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Sigurdardottir, Solveig; Eiriksdottir, Audur; Gunnarsdottir, Eva; Meintema, Marrit; Arnadottir, Unnur; Vik, Torstein

    2008-01-01

    We describe the cognitive profile in a complete national cohort of children with cerebral palsy (CP). One hundred and twenty-seven Icelandic children (67 females, 60 males) with CP, born between 1985 and 2000 and assessed between the ages of 4 and 6 years 6 months (mean age 5y 5mo, SD 6mo), were included in the study. IQ was measured using the…

  16. Cognitive Profile in Young Icelandic Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Sigurdardottir, Solveig; Eiriksdottir, Audur; Gunnarsdottir, Eva; Meintema, Marrit; Arnadottir, Unnur; Vik, Torstein

    2008-01-01

    We describe the cognitive profile in a complete national cohort of children with cerebral palsy (CP). One hundred and twenty-seven Icelandic children (67 females, 60 males) with CP, born between 1985 and 2000 and assessed between the ages of 4 and 6 years 6 months (mean age 5y 5mo, SD 6mo), were included in the study. IQ was measured using the…

  17. Longitudinal modeling in sports: young swimmers' performance and biomechanics profile.

    PubMed

    Morais, Jorge E; Marques, Mário C; Marinho, Daniel A; Silva, António J; Barbosa, Tiago M

    2014-10-01

    New theories about dynamical systems highlight the multi-factorial interplay between determinant factors to achieve higher sports performances, including in swimming. Longitudinal research does provide useful information on the sportsmen's changes and how training help him to excel. These questions may be addressed in one single procedure such as latent growth modeling. The aim of the study was to model a latent growth curve of young swimmers' performance and biomechanics over a season. Fourteen boys (12.33 ± 0.65 years-old) and 16 girls (11.15 ± 0.55 years-old) were evaluated. Performance, stroke frequency, speed fluctuation, arm's propelling efficiency, active drag, active drag coefficient and power to overcome drag were collected in four different moments of the season. Latent growth curve modeling was computed to understand the longitudinal variation of performance (endogenous variables) over the season according to the biomechanics (exogenous variables). Latent growth curve modeling showed a high inter- and intra-subject variability in the performance growth. Gender had a significant effect at the baseline and during the performance growth. In each evaluation moment, different variables had a meaningful effect on performance (M1: Da, β = -0.62; M2: Da, β = -0.53; M3: η(p), β = 0.59; M4: SF, β = -0.57; all P < .001). The models' goodness-of-fit was 1.40 ⩽ χ(2)/df ⩽ 3.74 (good-reasonable). Latent modeling is a comprehensive way to gather insight about young swimmers' performance over time. Different variables were the main responsible for the performance improvement. A gender gap, intra- and inter-subject variability was verified. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Muon tomography in the Mont Terri underground rock laboratory

    NASA Astrophysics Data System (ADS)

    Lesparre, N.; Gibert, D.; Marteau, J.; Carlus, B.; Nussbaum, C.

    2012-04-01

    The Mont Terri underground rock laboratory (Switzerland) was excavated in a Mesozoic shale formation constituted by Opalinus clay. This impermeable formation presents suitable properties for hosting repository sites of radioactive waste. A muon telescope has been placed in this laboratory in October 2009 to establish the feasibility of the muon tomography and to test the sensor performance in a calm environment, where we are protected from atmospheric noisy particles. However, the presence of radon in the gallery as well as charged particles issued from the decay of gamma rays may create a background noise. This noise shift and smooths the signal inducing an under estimation of the rock density. The uncorrelated background has been measured by placing the planes of detection in anti-coincidence. This estimation is preponderant and has to be combined to the theoretical feasibility evaluation to determine the best experimental set-up to observe muon flux fluctuations due to density variations. The muon densitometry experience is here exposed with the estimation of its feasibility. The data acquired from different locations inside the underground laboratory are presented. They are compared to two models representing the layer above the laboratory corresponding to a minimum and a maximum muon flux expectation depending on the values of the rock density.

  19. Biopolitics, Terri Schiavo, and the sovereign subject of death.

    PubMed

    Bishop, Jeffrey P

    2008-12-01

    Humanity does not gradually progress from combat to combat until it arrives at universal reciprocity, where the rule of law finally replaces warfare; humanity installs each of its violences in a system of rules and thus proceeds from domination to domination. (Foucault, 1984, 85) In this essay, I take a note from Michel Foucault regarding the notion of biopolitics. For Foucault, biopolitics has both repressive and constitutive properties. Foucault's claim is that with the rise of modern government, the state became exceedingly concerned about the body politic, the bodies that make up the polis, including the health of those bodies. However, Giorgio Agamben claims that Foucault and all western political philosophy misses the relationship between power and Sovereignty, with disastrous results and totalizing tendencies. I explore the case of Terri Schiavo claiming that the social conservatives have attempted to politicize bare life in its legal maneuverings, but I also show how the social liberals open an uncontrollable space between life and death. Both the left and the right miss the aporia at the heart of western political philosophy, and bioethics is complicit in the totalizing effects of contemporary medicine.

  20. Mexican chihuahua cheese: sensory profiles of young cheese.

    PubMed

    Van Hekken, D L; Drake, M A; Corral, F J Molina; Prieto, V M Guerrero; Gardea, A A

    2006-10-01

    Sensory profiles of fresh semihard Chihuahua cheese produced in the northern Mexican state of Chihuahua were developed to characterize the flavors and textures of this traditionally made Hispanic-style cheese. Multiple allotments of Chihuahua cheese, 9 brands made with raw milk (RM) and 5 brands made with pasteurized milk (PM), were obtained within 3 d of manufacture from 12 different cheese plants throughout Chihuahua, México. Cheeses were shipped overnight to Wyndmoor, Pennsylvania, and flavor analyses were conducted within 14 to 18 d after manufacture. Four brands (2 RM and 2 PM cheeses) were then selected and multiple allotments were shipped at 3 distinct seasons over a 1-yr period for evaluation of flavor and texture. Microbial analysis was conducted prior to testing to ensure product safety. Descriptive analyses of cheese flavors and textures were conducted with panelists trained to use a universal or product-specific Spectrum intensity scale, respectively. Sensory profiles of cheeses varied among the different manufacturers. The most prominent flavor attributes were salty, sour, diacetyl, cooked, whey, bitter, and milk-fat. The RM cheeses had more intense sour, bitter, and prickle scores than the PM cheeses. Many cheese texture attributes were similar, but RM cheeses were perceived as softer than PM cheeses. As the demand for Hispanic-style cheeses increases, defining and understanding the sensory attributes of traditionally made Mexican cheeses provides guidance to cheese manufacturers as new ways are explored to improve the production and shelf life of the cheeses.

  1. Vineland Adaptive Behavior Scales: II Profile of Young Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Yang, Sabrina; Paynter, Jessica M.; Gilmore, Linda

    2016-01-01

    Adaptive behaviour is a crucial area of assessment for individuals with Autism Spectrum Disorder (ASD). This study examined the adaptive behaviour profile of 77 young children with ASD using the Vineland-II, and analysed factors associated with adaptive functioning. Consistent with previous research with the original Vineland a distinct autism…

  2. Biography Today. Profiles of People of Interest to Young Readers. Artists Series. Vol. 1, 1996.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This issue of "Biography Today" features 18 short biographies about artists in a format young readers can enjoy and understand. Each entry provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to information on birth, youth, early memories, education, first jobs, marriage and family, career highlights,…

  3. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 13.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This special subject volume on "Authors" was especially created to appeal to young readers in a format they can enjoy reading and readily understand. Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to information on birth,…

  4. Biography Today: Scientists & Inventors Series. Profiles of People of Interest to Young Readers. Vol. 1, 1996.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This issue of "Biography Today" looks at scientists and inventors and is created to appeal to young readers in a format they can and enjoy and easily understand. Each entry provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to information on birth, youth, early memories, education, first jobs, marriage…

  5. Biography Today: Profiles of People of Interest to Young Readers. Sports Series, Volume 9.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This ninth volume of the "Biography Today Sports" series is intended to appeal to young readers in a format they can enjoy reading and readily understand. Each alphabetically-arranged sketch provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to information on birth, youth, early memories,…

  6. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 6.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This book provides biographical profiles of 11 authors of interest to readers ages 9 and above and was created to appeal to young readers in a format they can enjoy reading and readily understand. Biographies were prepared after extensive research, and each volume contains a cumulative index, a general index, a place of birth index, and a birthday…

  7. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 12.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This special subject volume, "Biography Today Author Series," Volume 12, was designed to appeal to young readers in a format they can enjoy reading and readily understand. Each volume contains alphabetically arranged sketches; each entry provides at least one photograph of the individual profiled, and bold-faced rubrics lead the reader…

  8. Vineland Adaptive Behavior Scales: II Profile of Young Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Yang, Sabrina; Paynter, Jessica M.; Gilmore, Linda

    2016-01-01

    Adaptive behaviour is a crucial area of assessment for individuals with Autism Spectrum Disorder (ASD). This study examined the adaptive behaviour profile of 77 young children with ASD using the Vineland-II, and analysed factors associated with adaptive functioning. Consistent with previous research with the original Vineland a distinct autism…

  9. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 9.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This book presents biographical profiles of 10 authors of interest to readers ages 9 and above and was created to appeal to young readers in a format they can enjoy and readily understand. Biographies were prepared after extensive research, and each volume contains a cumulative index, a general index, a place of birth index, and a birthday index.…

  10. Biography Today: Profiles of People of Interest to Young Readers. Scientists & Inventors Series.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    2002-01-01

    This volume on "Scientists and Inventors" was created to appeal to young readers in a format they can enjoy reading and can readily understand. Each volume contains alphabetically arranged sketches of outstanding people. Each entry provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to…

  11. Profile of Relevant Attitudes, Perceptions and Aspirations of Young Micronesians. Volume II.

    ERIC Educational Resources Information Center

    Broadbent, William A.

    The primary purpose of this study was to identify and profile attitudes and evaluative semantic differentials evidenced by young people in the six districts of Micronesia. Data were collected using a questionnaire. Eight attitudinal dimensions were measured: support of school and school related values, support of United States policy in…

  12. A Profile of Relevant Attitudes, Perceptions and Aspirations of Young Micronesians. Volume I.

    ERIC Educational Resources Information Center

    Broadbent, William A.

    The primary purpose of this study was to identify and profile attitudes and evaluative semantic differentials evidenced by young people in the six districts of Micronesia. Data were collected using a questionnaire. Eight attitudinal dimensions were measured: support of school and school related values, support of United States policy in…

  13. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 14.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This special subject volume of biographies of authors was created to appeal to young readers in a format they can enjoy reading and readily understand. Each entry provides at least one picture of the individual profiled, and bold-faced rubrics lead the reader to information on birth, youth, early memories, education, first jobs, marriage and…

  14. Biography Today: Profiles of People of Interest to Young Readers. Scientists & Inventors Series, Volume 5.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This book, a special volume focusing on computer-related scientists and inventors, provides 12 biographical profiles of interest to readers ages 9 and above. The Biography Today series was created to appeal to young readers in a format they can enjoy reading and readily understand. Each entry provides at least one picture of the individual…

  15. Biography Today: Sports Series. Profiles of People of Interest to Young Readers. Volume 3, 1999.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This third volume is part of a series of biographies that profile individuals of interest to young people over the age of 9 years. The entries in this volume include Joe Dumars, basketball; Jim Harbaugh, football; Dominik Hasek, hockey; Michelle Kwan, figure skating; Rebecca Lobo, basketball; Greg Maddux, baseball; Fatuma Roba, marathon running;…

  16. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 5.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    As with the regular issues of "Biography Today," this special subject volume on "Authors" was created to appeal to young readers in a format they can enjoy reading and readily understand. Each volume contains alphabetically-arranged sketches. Each entry in the volume provides at least one picture of the individual profiled, and…

  17. Identification of young modulus profile in PVC foam core thickness using speckle inteferometry and inverse method

    NASA Astrophysics Data System (ADS)

    Ferreira, Carlos; Casari, Pascal; Bouzidi, Rabah; Jacquemin, Frédéric

    2006-09-01

    The aim of this paper is to investigate the mechanical properties of a PVC foam core and especially the Young modulus profile along a commercialised 50 mm beam thickness. The identification of the Young modulus gradient is realized through the uniaxial compression test of a 50 mm cube sample. The in-plane strain fields of one cube face under loading in both directions (longitudinal and transversal) are achieved using a diffuse light interferometric technique, the speckle interferometry. Next to that, a numerical model is built using finite elements code CAST3M. We choose a multilayer model in order to introduce spatial variation of the mechanical properties. The boundaries conditions are very close to those prescribed in the experimental tests. Finally, the present work shows that the non uniform profile of the Young modulus can be estimated by using a simple inverse method and the finite elements analysis to reproduce the experimental strain field.

  18. Physiological profiles of young boys training in ballet.

    PubMed Central

    Pekkarinen, H; Litmanen, H; Mahlamäki, S

    1989-01-01

    In order to evaluate physiological characteristics in young male ballet dancers, 27 boys (aged 9 to 16 years) who participated in a boys' dance course during the Kuopio Dance and Music Festival in June 1988 were studied. In general, the boys had started dancing at the age of 8.6 years and had been training for 4.1 years. They had, on average, three dancing sessions per week and the mean time spent on dancing was four hours per week. In the study, some anthropometric measurements were taken, the maximal oxygen uptake (VO2 max) was measured by a cycle ergometer test and the explosive strength and the mechanical power of lower extremities were evaluated by a jumping test. The results indicate that boys who train in ballet are in general moderately lean, have relatively small body size and a high degree of flexibility. The younger boys especially have only moderate aerobic power, but both explosive strength and mechanical power in leg muscles are good in ballet trained boys. PMID:2630002

  19. Typological Analysis of Victimization Profiles of Young Children.

    PubMed

    Robert-Mazaye, Christelle; Clément, Marie-Ève; Cyr, Katie; Chamberland, Claire

    2017-04-01

    Although the scope of violence against children has been well documented, the reality of this phenomenon remains to be examined. Using data collected during a populationbased survey on the polyvictimization of children between 2 and 11 years old, this study explores the profiles of 972 children who are victims of many forms of violence (in family, school, and/or community). Cluster analyses identified 4 groups (minimal victimization, generalized victimization, threatening environment, aggressive environment), which differ according to the forms and extent of the violence experienced. The role of age, gender, and adverse life events in forming groups is also examined, as are the links with mental health disorders. Fostering the examination of the phenomenon of violence against children in all its diversity, this taxonomy presents advantages for researchers and professionals, which are discussed.

  20. A physiological and nutritional profile of young female figure skaters.

    PubMed

    Delistraty, D A; Reisman, E J; Snipes, M

    1992-06-01

    This study was undertaken to develop a physiological and nutritional profile of 13 female figure skaters, aged 9-17 years. Compared with previous published data, skaters in this study were younger and smaller with a higher percent body fat. Skaters in this study were less experienced and trained less than skaters in other studies but attained similar levels of maximal oxygen uptake (VO2max), handgrip strength, and vertical jump power. Relative VO2max (ml/kg/min) was significantly negatively correlated (p less than 0.0033) with body weight and percent body fat, while body weight was significantly positively correlated (p less than 0.0003) with handgrip strength and vertical jump power. In terms of nutritional recommendations, skaters in this study consumed comparatively high amounts of fat and protein with low amounts of carbohydrate, calcium, and iron. Despite suboptimal nutrition and a relatively low training volume, skaters in this study exhibited physiological characteristics similar to those reported for female figure skaters in the literature.

  1. Personality profile in young current regular users of cocaine.

    PubMed

    Herrero, M Jesús; Domingo-Salvany, Antonia; Torrens, Marta; Brugal, M Teresa; Gutiérrez, Fernando

    2008-01-01

    This study examined the relationship between the personality profile of a sample of cocaine users and the presence of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnoses and the severity of substance use. A total of 120 participants (46 women, mean age: 23.8 years) from nonclinical settings in Barcelona, Spain, 2003-2006, were assessed using the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) and the Temperament and Character Inventory-Revised version (TCI-R). Most of the participants had completed more than primary education, nearly half of them were employed, one third lived with parents, and near a quarter had some criminal record. Snorting was the main route of cocaine administration. They were using a mean of 1.82 substances. Cocaine users with low Self-Directedness, low Cooperativeness, and high Self-Transcendence scores in the TCI-R, with high severity of substance use and psychiatric comorbidity, would be suggestive of a possible specific phenotype. The limitations and implications of the study are discussed.

  2. Legally tripping: a qualitative profile of Salvia divinorum use among young adults.

    PubMed

    Kelly, Brian C

    2011-01-01

    During recent years, there has been increasing interest in "legal highs" among youth and young adults. Salvia divinorum is a legally available hallucinogenic plant, primarily utilized in smokable form, that produces a brief but intense hallucinogenic experience for the user. Data are presented from an ethnographic project to provide a qualitative profile of salvia use among young adults. Most users report primarily using in home settings such as apartments and houses, although a significant minority report use in environments such as parks, bars, and parties. The intense nature of the substance creates a differential subjective experience. Some describe the intensity of the hallucinogenic experience in positive ways. Others find the experience so intense that they would not continue to use the substance. With regard to the health effects of salvia, most young adults report no significant negative health effects from salvia use, although some report a mental cloudiness. Beyond their own experiences, users did not report any negative health events among peers. The lack of reports of negative effects may reinforce social norms favorable towards salvia use. Overall, young adults report a relatively low risk profile for salvia divinorum, which may be influenced, in part, by its legal status.

  3. GMT007_09_33_Terry Virts_India Maldives night zoom chennai colum

    NASA Image and Video Library

    2015-01-06

    ISS042eE01551 (01/06/2015) --- NASA astronaut Terry Virts tweeted this night image out with the twinkling city lights of the coast of India and the Maldives. The Maldives is a tropical nation in the Indian Ocean composed of 26 coral atolls, which stretch for hundreds of islands. It’s known for its beaches, blue lagoons and extensive reefs. Terry tweeted this comment along with the image: " Moonlit clouds over southeast #India coastline, with Chennai, Bangalore, and Hyderabad."

  4. Physical fitness profiles of young men: associations between physical fitness, obesity and health.

    PubMed

    Kyröläinen, Heikki; Santtila, Matti; Nindl, Bradley C; Vasankari, Tommi

    2010-11-01

    Obesity in youth has increased during the last 10 years in Western countries. Several studies have investigated physical activity and its effects on obesity and health, showing that regular physical activity combined with improved physical fitness reduces the risk of obesity and several metabolic problems (e.g. diabetes mellitus, metabolic syndrome, heart disease) and also improves overall health. However, there is only limited scientific information available concerning the changes in the physical fitness profiles of youth. It is obvious that only slight changes observed in endurance-type physical activity can also be observed in aerobic capacity. Today and in the future, a major public health concern for teenage and young adults is the combination of increasing body fatness together with decreasing physical fitness. In order to evaluate overall fitness level, it is particularly essential to examine both aerobic and neuromuscular fitness. Therefore, in clinical practice work and health behaviour education, a person's physical fitness should be measured more frequently with various measures. Furthermore, population-based surveys should be combined with regular measurement of physical fitness to study sedentary lifestyles, particularly in young people. This article presents a review of current physical fitness profiles of male children, adolescents and young adults, which hopefully initiates further studies in this relevant scientific field. In addition, the importance of physical fitness level is evaluated in relation to obesity and health. Collectively, studies examining physical fitness profiles of young men suggest a disturbing worldwide trend of decreased aerobic fitness and increased obesity. Continued efforts to foster improved physical fitness and healthy lifestyles should be encouraged to combat these trends. Such efforts should include frequent and objective assessment of physical fitness rather than solely relying on subjective assessment of physical

  5. Frictional Properties of Main Fault Gouge of Mont Terri, Switzerland

    NASA Astrophysics Data System (ADS)

    Aoki, K.; Seshimo, K.; Guglielmi, Y.; Nussbaum, C.; Shimamoto, T.; Ma, S.; Yao, L.; Kametaka, M.; Sakai, T.

    2016-12-01

    JAEA participated in the Fault Slip Experiment of Mont Terri Project which aims at understanding (i) the conditions for slip activation and stability of clay faults, and (ii) the evolution of the coupling between fault slip, pore pressure and fluids migration. The experiment uses SIMFIP probe to estimate (i) the hydraulic and elastic properties of fault zone elements, (ii) the state of stresses across the fault zone and (iii) the fault zone apparent strength properties (friction coefficient and cohesion). To elaborate on the Fault Slip Experiment, JAEA performed friction experiment of borehole cores of depths 47.2m and 37.3m using a rotary-shear low to high-velocity friction apparatus at Institute of Geology, China Earthquake Administration. Friction experiments were performed either dry with room humidity or with 30wt% of H2O, at a normal stress of 1.38 MPa and at low to intermediate slip rates ranging 0.21 microns/s to 2.1mm/s. Sample from a depth of 37.3 m is a fault rock with scaly fabric with calcite veins, whereas that from 47.2 m in depth is a pelitic rock that disaggregates easily with water. Main experimental results are summarized as follows. (1) Gouge samples from both depths exhibit slight velocity-strengthening at V below 0.021 mm/s and notable velocity strengthening at V above approximately 0.021 mm/s. Frictional regimes can be classified into low-velocity and intermediate-velocity regimes, characterized by slight and clear velocity-strengthening behaviors, respectively. (2) Wet gouge from a depth of 47.2 m has mss of 0.12 0.2 at low V and 0.11 0.24 at intermediate V, while dry gouge from the same depth has mss two to three times as high as that for the wet gouge from the same depth. (3) In contrast, both dry and wet gouges from a depth of 37.3 m has mss of around 0.4 to 0.74 at low V and from around 0.45 to 0.75 at intermediate V. There are almost no differences between the dry and wet gouges from this depth (4) The wet gouge from 47.2 m depths has

  6. Transition to Adulthood: Validation of the Rotterdam Transition Profile for Young Adults with Cerebral Palsy and Normal Intelligence

    ERIC Educational Resources Information Center

    Donkervoort, Mireille; Wiegerink, Diana J. H. G.; van Meeteren, Jetty; Stam, Henk J.; Roebroeck, Marij E.

    2009-01-01

    The aim of this study was to investigate the validity of the Rotterdam Transition Profile (RTP) to describe the transition process from childhood to adulthood in young adults with cerebral palsy (CP). Participants were recruited from rehabilitation centres and hospital departments of rehabilitation. In total, 81 young adults (47 males, 34 females)…

  7. Transition to Adulthood: Validation of the Rotterdam Transition Profile for Young Adults with Cerebral Palsy and Normal Intelligence

    ERIC Educational Resources Information Center

    Donkervoort, Mireille; Wiegerink, Diana J. H. G.; van Meeteren, Jetty; Stam, Henk J.; Roebroeck, Marij E.

    2009-01-01

    The aim of this study was to investigate the validity of the Rotterdam Transition Profile (RTP) to describe the transition process from childhood to adulthood in young adults with cerebral palsy (CP). Participants were recruited from rehabilitation centres and hospital departments of rehabilitation. In total, 81 young adults (47 males, 34 females)…

  8. Lack of Association between Polymorphisms of Hepatic Lipase with Lipid Profile in Young Jordanian Adults.

    PubMed

    Khabour, Omar F; Alomari, Mahmoud A; Alzoubi, Karem H; Gharaibeh, Mohammad Y; Alhashimi, Farah H

    2014-01-01

    The human hepatic lipase (LIPC) gene encodes hepatic lipase, an enzyme involved in lipoprotein metabolism and regulation. Therefore, variants in LIPC gene may influence plasma lipoprotein levels. In this study, the association of LIPC C-514T and G-250A polymorphisms with plasma lipid profiles in 348 young Jordanians was investigated. Genotyping of C-514T and G-250A was performed by polymerase chain reaction and subsequent digestion with DraI and NiaIII restriction enzymes, respectively, while Roche analyzer was used to determine plasma total cholesterol, triglycerides, low-and high-density lipoprotein. The G-250 and C-514 alleles were most abundant in Jordanians with 79 and 80% frequencies, respectively. Additionally, no difference was found in the lipid-lipoprotein profile between the different genotype groups of C-514T or G-250A polymorphisms, even when males and females were examined separately (P > 0.05). In young Jordanian adults, the examined LIPC polymorphisms seem to play a limited role in determining the lipid profile.

  9. Consumption of pasteurized human lysozyme transgenic goats’ milk alters serum metabolite profile in young pigs

    PubMed Central

    Brundige, Dottie R.; Maga, Elizabeth A.; Klasing, Kirk C.

    2009-01-01

    Nutrition, bacterial composition of the gastrointestinal tract, and general health status can all influence the metabolic profile of an organism. We previously demonstrated that feeding pasteurized transgenic goats’ milk expressing human lysozyme (hLZ) can positively impact intestinal morphology and modulate intestinal microbiota composition in young pigs. The objective of this study was to further examine the effect of consuming hLZ-containing milk on young pigs by profiling serum metabolites. Pigs were placed into two groups and fed a diet of solid food and either control (non-transgenic) goats’ milk or milk from hLZ-transgenic goats for 6 weeks. Serum samples were collected at the end of the feeding period and global metabolite profiling was performed. For a total of 225 metabolites (160 known, 65 unknown) semi-quantitative data was obtained. Levels of 18 known and 4 unknown metabolites differed significantly between the two groups with the direction of change in 13 of the 18 known metabolites being almost entirely congruent with improved health status, particularly in terms of the gastrointestinal tract health and immune response, with the effects of the other five being neutral or unknown. These results further support our hypothesis that consumption of hLZ-containing milk is beneficial to health. PMID:19847666

  10. Adolescent personality profiles, neighborhood income, and young adult alcohol use: a longitudinal study.

    PubMed

    Ayer, Lynsay; Rettew, David; Althoff, Robert R; Willemsen, Gonneke; Ligthart, Lannie; Hudziak, James J; Boomsma, Dorret I

    2011-12-01

    Personality traits and socioeconomic factors such as neighborhood income have been identified as risk factors for future alcohol abuse, but findings have been inconsistent possibly due to interactions between risk and protective factors. The present study examined the prediction of drinking behavior using empirically derived multi-trait patterns and tested for moderation by average neighborhood income. Using latent profile analysis (LPA) in a sample of 863 Dutch adolescents, four empirical personality profiles based on 6 traits were observed: Extraverted, Dysregulated, Neurotic, and Regulated. Dysregulated and Extraverted youth drank higher quantities of alcohol more frequently in young adulthood relative to the Regulated group, above and beyond the effects of baseline adolescent drinking, age, and sex. Profile levels of neuroticism did not appear to affect drinking behavior. Average neighborhood income did not moderate adolescent personality and young adult drinking. These findings suggest that future alcohol research should consider individual trait patterns to inform prevention and intervention efforts, and theories implicating both positive and negative emotionality traits as risk factors for drinking are preferable to those emphasizing the importance of the latter.

  11. Adolescent Personality Profiles, Neighborhood Income, and Young Adult Alcohol Use: A Longitudinal Study

    PubMed Central

    Ayer, Lynsay; Rettew, David; Althoff, Robert R.; Willemsen, Gonneke; Ligthart, Lannie; Hudziak, James J.; Boomsma, Dorret I.

    2011-01-01

    Personality traits and socioeconomic factors such as neighborhood income have been identified as risk factors for future alcohol abuse, but findings have been inconsistent possibly due to interactions between risk and protective factors. The present study examined the prediction of drinking behavior using empirically derived multi-trait patterns and tested for moderation by average neighborhood income. Using latent profile analysis (LPA) in a sample of 863 Dutch adolescents, four empirical personality profiles based on 6 traits were observed: Extraverted, Dysregulated, Neurotic, and Regulated. Dysregulated and Extraverted youth drank higher quantities of alcohol more frequently in young adulthood relative to the Regulated group, above and beyond the effects of baseline adolescent drinking, age, and sex. Profile levels of neuroticism did not appear to affect drinking behavior. Average neighborhood income did not moderate adolescent personality and young adult drinking. These findings suggest that future alcohol research should consider individual trait patterns to inform prevention and intervention efforts, and theories implicating both positive and negative emotionality traits as risk factors for drinking are preferable to those emphasizing the importance of the latter. PMID:21820248

  12. Adolescents who assault their parents:a different family profile of young offenders?

    PubMed

    Contreras, Lourdes; Cano, Carmen

    2014-01-01

    Some authors have proposed that the mechanisms underlying adolescent-to-parent abuse seem to be different from other forms of juvenile delinquency. Given that this aggression is exerted within the family setting, our study was aimed to explore if there was a differential family profile for those adolescents who commit a parent abuse offense compared to those who commit other types of offenses. Judicial files of 1,046 young offenders from the Juvenile Justice Service of Jaén (Spain) were examined. The final sample (654 young offenders) was divided into 2 groups: those who had committed offenses against a parent (parent abuse group) and those who had committed other types of offenses (other offenses group). Results showed that families with parent abuse have differential characteristics, especially regarding the family size, type of household, parenting styles, and the patterns of interactions between the family members.

  13. Accounting for Individual Differences in Bradley-Terry Models by Means of Recursive Partitioning

    ERIC Educational Resources Information Center

    Strobl, Carolin; Wickelmaier, Florian; Zeileis, Achim

    2011-01-01

    The preference scaling of a group of subjects may not be homogeneous, but different groups of subjects with certain characteristics may show different preference scalings, each of which can be derived from paired comparisons by means of the Bradley-Terry model. Usually, either different models are fit in predefined subsets of the sample or the…

  14. Accounting for Individual Differences in Bradley-Terry Models by Means of Recursive Partitioning

    ERIC Educational Resources Information Center

    Strobl, Carolin; Wickelmaier, Florian; Zeileis, Achim

    2011-01-01

    The preference scaling of a group of subjects may not be homogeneous, but different groups of subjects with certain characteristics may show different preference scalings, each of which can be derived from paired comparisons by means of the Bradley-Terry model. Usually, either different models are fit in predefined subsets of the sample or the…

  15. Astronauts Sally Ride and Terry Hart prepare for RMS training for STS-2

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronauts Sally Ride and Terry Hart prepare for remote manipulator system (RMS) training for STS-2 in bldg 9A. Views include Ride, Hart and Robert R. Kain of the Flight Activites Branch reviewing procedures for RMS training (34262); Ride and Hart stand beside the RMS control center looking down at the payload bay mock-up (34263).

  16. Astronauts Sally Ride and Terry Hart prepare for RMS training for STS-2

    NASA Image and Video Library

    1981-07-17

    Astronauts Sally Ride and Terry Hart prepare for remote manipulator system (RMS) training for STS-2 in bldg 9A. Views include Ride, Hart and Robert R. Kain of the Flight Activites Branch reviewing procedures for RMS training (34262); Ride and Hart stand beside the RMS control center looking down at the payload bay mock-up (34263).

  17. Astronauts Sally Ride and Terry Hart prepare for RMS training for STS-2

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronauts Sally Ride and Terry Hart prepare for remote manipulator system (RMS) training for STS-2 in bldg 9A. Views include Ride, Hart and Robert R. Kain of the Flight Activites Branch reviewing procedures for RMS training (34262); Ride and Hart stand beside the RMS control center looking down at the payload bay mock-up (34263).

  18. Astronaut Terry J. Hart in training session RMS for STS-2 bldg 29

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut Terry J. Hart in training session with the Remote Manipulator System (RMS) for STS-2 bldg 29. Views show Truly working at the command console while watching out the windows. Karen Ehlers, an RMS procedures specialist, can be seen at left side of frame while Astronaut Sally Ride waits on right for her time at the RMS.

  19. Extending the Shoreline of Wonder through the Research Attic of J. Terry Gates

    ERIC Educational Resources Information Center

    Kuebel, Christa

    2017-01-01

    This article is a review of the Ohio Music Education Association Graduate Research Forum presentation from February 2017 in Cleveland. Each year, an expert in the field of music education is invited to the state conference to discuss research, practice, teaching, and learning. The presenter was Dr. J. Terry Gates of "The Hoenny Center for…

  20. A Reflective Conversation with Terry Friedrichs on Teaching Academics to Gifted Students with Asperger Syndrome

    ERIC Educational Resources Information Center

    Friedrichs, Terence Paul; Shaughnessy, Michael F.

    2015-01-01

    In this reflective interview with Terry Friedrichs--a hands-on academic-learning specialist and researcher with gifted students with Asperger Syndrome--he defines these pupils, describes their "straightforward" and confusing traits, and recounts his initial and later instructional experiences with them over several decades. The piece…

  1. Why Students in Catholic Secondary Schools Should Study Pope John XXIII's Encyclical, "Pacem in Terris" (1963)

    ERIC Educational Resources Information Center

    Sweeney, James

    2015-01-01

    Pope John XXIII's final encyclical on the subject of peace, "Pacem in Terris," written after the Cuban missile crisis which he helped to resolve, is an extended treatment of the basic principles of political morality and particularly significant for its adoption--the first time by the Catholic Church--of the discourse of human rights.…

  2. A Reflective Conversation with Terry Friedrichs on Teaching Academics to Gifted Students with Asperger Syndrome

    ERIC Educational Resources Information Center

    Friedrichs, Terence Paul; Shaughnessy, Michael F.

    2015-01-01

    In this reflective interview with Terry Friedrichs--a hands-on academic-learning specialist and researcher with gifted students with Asperger Syndrome--he defines these pupils, describes their "straightforward" and confusing traits, and recounts his initial and later instructional experiences with them over several decades. The piece…

  3. Impact of Diet Containing Grape Pomace on Growth Performance and Blood Lipid Profile of Young Rats.

    PubMed

    Smith, Ivy; Yu, Jianmei; Hurley, Steven L; Hanner, Tracy

    2017-06-01

    Grape pomace (GP), the residue of grapes after wine making, is rich in dietary polyphenols and fiber, and it has potential to serve as a functional food ingredient to improve health. However, high polyphenol diets have also been reported to inhibit the growth of young animals and cause liver necrosis. This study investigated the effect of diets containing different amounts of GP on the growth performance and blood lipid profile by using a young rat model. Twenty female Sprague-Dawley rats of age 7 weeks were randomly divided into four groups that were fed AIN-93G diets that were modified by substituting 0%, 10%, 20%, and 30% of carbohydrate with GP for 10 weeks (the diets, thus, obtained contained 0%, 6.9%, 13.8%, and 20.7% of GP). The group fed original AIN-93G (0% GP) was used as control. Feed consumption, body weight, length, and height were recorded weekly. Blood samples were taken biweekly to analyze plasma lipid profile. At the end of the feeding period, the rats were fasted overnight and euthanized by exsanguination under anesthesia. Livers, hearts, and kidneys were collected, and their weights were recorded. Results show that the diet containing a maximum of 20.7% of GP did not influence the body weights, lengths, and heights of rats. As the GP content increased, the blood triglyceride and very low-density lipoproteins (VLDL) decreased, the high-density lipoprotein (HDL) and low-density lipoprotein (LDL) increased slightly but were statistically significant, and total cholesterol remained constant. In conclusion, GP in the AIN-93G diet did not influence the growth performance of young rats, but it exhibited both positive and negative effects on the blood lipid profile.

  4. Behavioural profile and maternal stress in Greek young children with Williams syndrome.

    PubMed

    Papaeliou, C; Polemikos, N; Fryssira, E; Kodakos, A; Kaila, M; Yiota, X; Benaveli, E; Michaelides, C; Stroggilos, V; Vrettopoulou, M

    2012-11-01

    Williams syndrome (WS) is a genetic disorder causing intellectual disability. Children with WS often exhibit various kinds of maladaptive behaviours that affect their social functioning. In order to determine whether these behaviours are syndrome-specific, it would be necessary to compare children with WS with children with other syndromes as well as to provide data on the socio-emotional profile in WS from a variety of cultures. The present study investigated the behavioural profile and its relation to maternal stress in Greek young children with WS in comparison with young children with Down syndrome and typically developing (TD) children. Participants were 60 mothers, 20 in each syndrome group and 20 in the control group. The three groups were matched for mental age. The behavioural profile of the participants was investigated through the Child Behaviour Checklist (1.5-5 years) and maternal stress through the Parental Stress Index. In accordance with studies in other cultures, it was found that young children with WS received significantly higher rates in emotional problems and anxiety/depression, compared with both children with Down syndrome and TD children. Moreover, mothers of children with WS reported significantly higher scores in the Total Stress index compared with mothers of TD children. However, in contrast with previous studies, only 25% of children with WS fell into the clinical range in the total Child Behavior Checklist score. The consistency of the socio-emotional characteristics of children with WS across cultures and developmental stages implies a strong influence of the genetic phenotype. However, Greek mothers avoided to characterize these behaviours as pathological. Implications of these findings for clinical practice are also discussed. © 2011 Blackwell Publishing Ltd.

  5. 100 Most Popular Business Leaders for Young Adults: Biographical Sketches and Professional Paths. Profiles and Pathways Series.

    ERIC Educational Resources Information Center

    Logan, Rochelle; Halverstadt, Julie

    This book, which is intended as a reference for teenagers and educators, profiles the lives and professional paths of the 100 most popular business leaders for young adults. Those profiled were selected for a number of reasons, including the following: their names are recognizable; they are associated with businesses and industries that are…

  6. 100 Most Popular Business Leaders for Young Adults: Biographical Sketches and Professional Paths. Profiles and Pathways Series.

    ERIC Educational Resources Information Center

    Logan, Rochelle; Halverstadt, Julie

    This book, which is intended as a reference for teenagers and educators, profiles the lives and professional paths of the 100 most popular business leaders for young adults. Those profiled were selected for a number of reasons, including the following: their names are recognizable; they are associated with businesses and industries that are…

  7. Novel atherosclerotic risk factors and angiographic profile of young Gujarati patients with acute coronary syndrome.

    PubMed

    Prajapati, Jayesh; Jain, Sharad; Virpariya, Kapil; Rawal, Jayesh; Joshi, Hasit; Sharma, Kamal; Roy, Bhavesh; Thakkar, Ashok

    2014-07-01

    In this study we aimed to analyse the frequency of atherosclerotic risk factors with focus to novel risk factors for coronary artery disease and angiographic profile in young (≤ 40 years) acute coronary syndrome (ACS) patient with healthy controls in Gujarat, India. Between January 2008 and December 2012, 109 consecutive young patients aged ≤ 40 years old, diagnosed to have ACS were included in the study. All ACS patients underwent diagnostic coronary angiography. An equivalent age and sex matched population without coronary disease with similar risk factors without tobacco considered a control group. All angiographic patients were evaluated for conventional risk factors for coronary artery disease like diabetes mellitus, hypertension, smoking, obesity as well as novel atherogenic risk factors like high sensitivity C-reactive protein (Hs-CRP), Lipoprotein(a) [LP(a)], homocysteine, apolipoprotein A1 (ApoA1) and B (ApoB). In a study group, out of 109 young patients, 90 (82.6%) patients were presented to our hospital as ST-segment elevation myocardial infarction (STEMI), 10 (9.2%) presented as known non-ST-elevation myocardial infarction (NSTEMI) and 9 (8.3%) presented as unstable angina (UA). Serum cholesterol, triglycerides, LDL, LP(a) and lipid tetrad index were significantly higher in the study group whereas the HDL levels significantly lower as compared to the control group. A quite common risk factors of premature CAD are smoking, high Hs-CRP, high LP(a), hyperhomocysteinaemia and positive family history in the young ACS. Most common presentation of ACS in young was STEMI. On angiography, single vessel involvement was the most common finding.

  8. Vineland Adaptive Behavior Scales: II Profile of Young Children with Autism Spectrum Disorder.

    PubMed

    Yang, Sabrina; Paynter, Jessica M; Gilmore, Linda

    2016-01-01

    Adaptive behaviour is a crucial area of assessment for individuals with Autism Spectrum Disorder (ASD). This study examined the adaptive behaviour profile of 77 young children with ASD using the Vineland-II, and analysed factors associated with adaptive functioning. Consistent with previous research with the original Vineland a distinct autism profile of Vineland-II age equivalent scores, but not standard scores, was found. Highest scores were in motor skills and lowest scores were in socialisation. The addition of the Autism Diagnostic Observation Schedule calibrated severity score did not contribute significant variance to Vineland-II scores beyond that accounted for by age and nonverbal ability. Limitations, future directions, and implications are discussed.

  9. Angle specificity of the knee extensor age-related profile in young female athletes.

    PubMed

    Rousanoglou, E N; Boudolos, K D

    2008-01-01

    The angle specificity of the knee extensor age-related profile was examined in young females (13-19 yr). Twenty-one track & field jumpers, 20 volleyball players and 20 non-active females were separated into the youngest and the oldest age categories, based on the official competitive age categories. The maximum knee extensor isometric torque (T MAX) was measured at 9 knee angles. The relationships between T MAX at the peak of the torque-angle curve and at the other knee angles (angle-angle relationships) were expressed by R2 (%). Statistics included two-way ANOVA for age category differences and curve fitting to R2 joint angle trend lines. Differences between age categories were significant for the volleyball players and the non-active females (p < 0.05). Age category had an angle specific impact on angle-angle relationships in the athletes, with the youngest ones demonstrating greater R2 decrease at the more extended, or more flexed, knee angles. Significant quadratic R2 joint angle trend lines were found in all track & field jumpers (p < 0.05) and, in the youngest only volleyball players (p < 0.05), but not in the non-active females (p > 0.05). In conclusion, the knee extensor profiles of young female athletes show an age-related angle specificity that should be accounted for when treating athletes within the age range examined.

  10. [Alteration of serum lipid profile in young men with different somatotypes after food load].

    PubMed

    Fefelova, V V; Koloskova, T P; Kazakova, T V; Fefelova, Yu A

    2015-01-01

    Serum lipid profiles of 76 men of young age (17-21years) were investigated using thin layer chromatography and determination of somatotypes was realized using the scheme of V.P. Chtetsov et al. (1978). The investigation was conducted on an empty stomach and after one hour after food loads (test meal with energy value of 419 kcal, content of proteins - 17,9 g, fats - 11,9 g, carbohydrates - 60,1 g). Regularities inherent to certain somatotypes were revealed. In young men with the abdominal somatotype (with the most pronounced fat component), changes evidencing membranes rigidity growth were revealed: cholesterol esterification processes inhibition and increase of sphingomyelin after meal (p = 0.001). In young men with muscular somatotype the highest level of phosphatidylcholine and the lowest level of easily-oxidized phospholipid fractions in comparison to other somatotypes [thoracic (p = 0.044), abdominal (p = 0.037) and undetermined (p = 0.021)] were registered. General rule is lowering of the free fatty acids levels after meal in comparison with the indices on the empty stomach for all somatotypes: thoracic (p = 0.0001), muscular (p = 0.012), abdominal (p = 0.041) and undetermined (p = 000018). Definiteness of the effect of lowering of free fatty acids levels after meal for all somatotypes could evidence the importance Of this process for maintaining the homeostatic body constants.

  11. Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age.

    PubMed

    Gooding, Holly C; Shay, Christina M; Ning, Hongyan; Gillman, Matthew W; Chiuve, Stephanie E; Reis, Jared P; Allen, Norrina B; Lloyd-Jones, Donald M

    2015-10-29

    Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH). This study quantified associations between combinations of healthy lifestyle components measured in young adulthood and loss of the ideal CVH profile into middle age. Analyses included 2164 young adults in the Coronary Artery Risk Development in Young Adults study with the ideal CVH profile (defined as untreated blood pressure <120/80 mm Hg, total cholesterol <200 mg/dL, fasting blood glucose <100 mg/dL, and absence of cardiovascular disease) at baseline. Cox proportional hazards regression models estimated hazard ratios for loss of the ideal CVH profile over 25 years according to 4 individual and 16 combinations of optimal healthy lifestyle components measured in young adulthood: body mass index, physical activity, nonsmoking status, and diet quality. Models were adjusted for age, sex, race, education, study center, and baseline blood pressure, cholesterol, and glucose. Eighty percent (n=1737) of participants lost the ideal CVH profile by middle age; loss was greatest for young adults with no optimal healthy lifestyle components at baseline. Relative to young adults with no optimal healthy lifestyle components, those with all 4 were less likely to lose the ideal CVH profile (hazard ratio 0.59, 95% CI 0.44-0.80). Combinations that included optimal body mass index and nonsmoking status were each associated with lower risk. Optimal body mass index and not smoking in young adulthood were protective against loss of the ideal CVH profile through middle age. Importance of diet and physical activity may be included through their effects on healthy weight. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  12. Characterisation of HTO diffusion properties by an in situ tracer experiment in Opalinus clay at Mont Terri.

    PubMed

    Palut, J-M; Montarnal, Ph; Gautschi, A; Tevissen, E; Mouche, E

    2003-03-01

    A long-term single borehole diffusion experiment using tritiated water as tracer was carried out in Opalinus clay, an argillaceous rock formation that is accessible at the Mont Terri Underground Research Laboratory, situated in the Swiss Jura. The tracer was diluted in reconstituted formation water and introduced into a packed-off section of a borehole located in saturated rock. Pressure in this interval was maintained equal to the pore pressure of the surrounding rock in order to prevent any hydraulic gradient around the borehole and to avoid advective transport processes. The evolution of the tracer concentration in the injection system was monitored over time. After 1 year of diffusion, the claystone surrounding the interval was retrieved by overcoring the whole borehole and packer system, and by an adjacent oblique borehole. Compressed air was used as drilling fluid to reduce rock disturbances. The recovered overcore was sampled along profiles perpendicular to the borehole wall with a view to determining the tracer-concentration profiles in the rock. To avoid further evaporation of tritiated water, subsamples were immediately transferred into polyethylene bottles and disaggregated by adding a known amount of tracer-free water. Fifteen profiles were determined and showed a decreasing tracer concentration with distance into the rock. The pore-water contents were constant along those profiles, confirming that only very little water was lost during overcoring operations. The evolution of tritium-tracer concentration in the injection system over time and in situ profiles were interpreted with a 3-D numerical simulation of the experiment. That allowed for the identification of the transport parameters (orthotropic diffusion tensor and porosity) by minimising the relative quadratic error between the experimental and simulated data. The fitting is good and the results are consistent with data obtained on drill-core samples. The result of tritiated water is discussed

  13. Profiles of Health Competence Beliefs Among Young Adult Survivors of Childhood Cancer

    PubMed Central

    Brier, Moriah J.; DeRosa, Branlyn Werba; Hocking, Matthew C.; Schwartz, Lisa A.; Ginsberg, Jill P.; Hobbie, Wendy; Ittenbach, Richard F.

    2011-01-01

    Purpose: The goal of this study was to identify profiles of young adult (YA)-aged cancer survivors' beliefs about their health and well-being. Survivors' beliefs and their associated psychosocial and demographic characteristics may be clinically useful in survivorship care. Patients and methods: YA survivors of pediatric leukemias (n=51), lymphomas (n=24), and solid tumors (n=44), aged 18–29 years old (N=119), were categorized using cluster analysis based on their responses to the Health Competence Beliefs Inventory, a measure assessing beliefs about their health, satisfaction with healthcare, autonomy, and cognitive competence. Profiles of beliefs generated by cluster analysis were examined using self-report measures of health problems, distress, demographics, and provider-reported health problems and cancer treatment intensity. Results: Three distinct clusters were identified: Adaptive (n=54), Low Autonomy (n=25), and Vulnerable (n=40). Adaptive survivors had positive beliefs, low distress, and minimal health problems. The Low Autonomy survivors were similar to those in the Adaptive cluster except they had low autonomy beliefs and the majority reported living with their parents. The Vulnerable cluster had more negative beliefs, the most medical problems, and the highest levels of distress. Conclusion: Health competence belief profiles identified unique subsets of YA survivors of pediatric cancer that have potentially distinct risk factors. Categorizing survivors by health belief patterns may help healthcare providers treat and educate their patients in ways that are tailored to individual survivors' needs and risks. PMID:23610738

  14. MicroRNA profile in very young women with breast cancer

    PubMed Central

    2014-01-01

    Background Breast cancer is rarely diagnosed in very young women (35years old or younger), and it often presents with distinct clinical-pathological features related to a more aggressive phenotype and worse prognosis when diagnosed at this early age. A pending question is whether breast cancer in very young women arises from the deregulation of different underlying mechanisms, something that will make this disease an entity differentiated from breast cancer diagnosed in older patients. Methods We performed a comprehensive study of miRNA expression using miRNA Affymetrix2.0 array on paraffin-embedded tumour tissue of 42 breast cancer patients 35 years old or younger, 17 patients between 45 and 65 years old and 29 older than 65 years. Data were statistically analyzed by t-test and a hierarchical clustering via average linkage method was conducted. Results were validated by qRT-PCR. Putative targeted pathways were obtained using DIANA miRPath online software. Results The results show a differential and unique miRNA expression profile of 121 miRNAs (p-value <0.05), 96 of those with a FDR-value <0.05. Hierarchical clustering grouped the samples according to their age, but not by subtype nor by tumour characteristics. We were able to validate by qRT-PCR differences in the expression of 6 miRNAs: miR-1228*, miR-3196, miR-1275, miR-92b, miR-139 and miR-1207. Moreover, all of the miRNAs maintained the expression trend. The validated miRNAs pointed out pathways related to cell motility, invasion and proliferation. Conclusions The study suggests that breast cancer in very young women appears as a distinct molecular signature. To our knowledge, this is the first time that a validated microRNA profile, distinctive to breast cancer in very young women, has been presented. The miRNA signature may be relevant to open an important field of research in order to elucidate the underlying mechanism in this particular disease, which in a more clinical setting, could potentially help to

  15. MicroRNA profile in very young women with breast cancer.

    PubMed

    Peña-Chilet, Maria; Martínez, Maria T; Pérez-Fidalgo, Jose A; Peiró-Chova, Lorena; Oltra, Sara S; Tormo, Eduardo; Alonso-Yuste, Elisa; Martinez-Delgado, Beatriz; Eroles, Pilar; Climent, Joan; Burgués, Octavio; Ferrer-Lozano, Jaime; Bosch, Ana; Lluch, Ana; Ribas, Gloria

    2014-07-21

    Breast cancer is rarely diagnosed in very young women (35 years old or younger), and it often presents with distinct clinical-pathological features related to a more aggressive phenotype and worse prognosis when diagnosed at this early age. A pending question is whether breast cancer in very young women arises from the deregulation of different underlying mechanisms, something that will make this disease an entity differentiated from breast cancer diagnosed in older patients. We performed a comprehensive study of miRNA expression using miRNA Affymetrix2.0 array on paraffin-embedded tumour tissue of 42 breast cancer patients 35 years old or younger, 17 patients between 45 and 65 years old and 29 older than 65 years. Data were statistically analyzed by t-test and a hierarchical clustering via average linkage method was conducted. Results were validated by qRT-PCR. Putative targeted pathways were obtained using DIANA miRPath online software. The results show a differential and unique miRNA expression profile of 121 miRNAs (p-value <0.05), 96 of those with a FDR-value <0.05. Hierarchical clustering grouped the samples according to their age, but not by subtype nor by tumour characteristics. We were able to validate by qRT-PCR differences in the expression of 6 miRNAs: miR-1228*, miR-3196, miR-1275, miR-92b, miR-139 and miR-1207. Moreover, all of the miRNAs maintained the expression trend. The validated miRNAs pointed out pathways related to cell motility, invasion and proliferation. The study suggests that breast cancer in very young women appears as a distinct molecular signature. To our knowledge, this is the first time that a validated microRNA profile, distinctive to breast cancer in very young women, has been presented. The miRNA signature may be relevant to open an important field of research in order to elucidate the underlying mechanism in this particular disease, which in a more clinical setting, could potentially help to identify therapeutic targets in this

  16. Systemic testing on Bradley-Terry model against nonlinear ranking hierarchy.

    PubMed

    Shev, Aaron; Fujii, Kevin; Hsieh, Fushing; McCowan, Brenda

    2014-01-01

    We take a system point of view toward constructing any power or ranking hierarchy onto a society of human or animal players. The most common hierarchy is the linear ranking, which is habitually used in nearly all real-world problems. A stronger version of linear ranking via increasing and unvarying winning potentials, known as Bradley-Terry model, is particularly popular. Only recently non-linear ranking hierarchy is discussed and developed through recognition of dominance information contents beyond direct dyadic win-and-loss. We take this development further by rigorously arguing for the necessity of accommodating system's global pattern information contents, and then introducing a systemic testing on Bradley-Terry model. Our test statistic with an ensemble based empirical distribution favorably compares with the Deviance test equipped with a Chi-squared asymptotic approximation. Several simulated and real data sets are analyzed throughout our development.

  17. Reliability of the Terry: a mental health cartoon-like screener for African-American children.

    PubMed

    Bidaut-Russell, M; Valla, J P; Thomas, J M; Bergeron, L; Lawson, E

    1998-01-01

    Test-retest reliability and internal consistency of the Terry, a cartoon-based child mental health screener developed for African-American children, were measured in 36 boys (age 5 1/2 to 13) in a test-retest design. Reliability of the diagnosis (0.70 < or = k < or = 0.75) was good for ADHD, ODD, CD, and OAD, and excellent for MDD and SAD. Because of low base-rate, no kappa value was calculated for SPh. Both test-retest agreement, and reliability of the symptom scale (0.75 < or = ICC < or = 0.80) were very good for all 7 diagnoses. Internal consistency according to symptom scale (0.78 < or = Cronbach alpha < or = 0.90), was moderate for OAD, good for SPh, MDD, SAD, CD, and ODD, and excellent for ADHD. The Terry is a culturally-sensitive questionnaire with good reliability.

  18. The comparison of microRNA profile of the dermis between the young and elderly.

    PubMed

    Li, Tong; Yan, Xianghong; Jiang, Min; Xiang, Leihong

    2016-05-01

    Skin aging is a process of structural and compositional remodeling that can be manifested as wrinkling and sagging. Remarkably, the dermis plays a dominant role in the process of skin aging. Recent studies suggest that microRNAs (miRNAs) may play a role in the regulation of gene expression in organism aging. However, studies about age-related miRNAs in human skin remain limited. To obtain an overall view of miRNAs expression in human aged dermis by comparison of dermis samples between young and elderly, construct the miRNA-gene-network and reveal the pivotal miRNAs in the regulatory network. Human dermis tissue was obtained from 12 donors, including 6 of young group and 6 of elderly one. The miRNA microarray and data analysis were performed. Target genes of differentially expressed miRNAs were predicted, followed by a gene ontology and pathway enrichment analysis. A miRNA-gene-network was then constructed, and the pivotal miRNAs in the network was revealed. Primary human dermal fibroblasts (HDFs) were isolated, and the cellular senescence was induced by serial passaging. Alteration in the expression of miRNAs between young and senescent fibroblasts was evaluated by real-time quantitative RT-PCR. MiR-34b-5p mimics were transfected into primary HDFs. Subsequent cell cycle analysis was performed and expression level of COL1A1, elastin and MMP-1 were evaluated. The expression of a total of 40 miRNAs (25 upregulated and 15 downregulated) was found to be significantly altered in aged dermis compared with young dermis. Real-time quantitative PCR results confirmed the differential expression of miR-34 family and miR-29 family between young and aged dermis. A computational approach demonstrated that predicted target genes of the miRNA profile were found to be mainly involved in processes including cell adhesion, collagen synthesis, positive or negative regulation of transcription, as well as pathways such as insulin signaling pathway, ErbB (Erythroblastic Leukemia Viral

  19. Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults.

    PubMed

    Bogl, L H; Pietiläinen, K H; Rissanen, A; Kangas, A J; Soininen, P; Rose, R J; Ala-Korpela, M; Kaprio, J

    2013-11-01

    Nutritional epidemiology is increasingly shifting its focus from studying single nutrients to the exploration of the whole diet utilizing dietary pattern analysis. We analyzed associations between habitual diet (including macronutrients, dietary patterns, biomarker of fish intake) and lipoprotein particle subclass profile in young adults. Complete dietary data (food-frequency questionnaire) and lipoprotein subclass profile (via nuclear magnetic resonance spectroscopy) were available for 663 subjects from the population-based FinnTwin12 study (57% women, age: 21-25 y). The serum docosahexaenoic to total fatty acid ratio was used as a biomarker of habitual fish consumption. Factor analysis identified 5 dietary patterns: "Fruit and vegetables", "Meat", "Sweets and desserts", "Junk food" and "Fish". After adjustment for sex, age, body mass index, waist circumference, physical activity, smoking status and alcohol intake, the "Junk food" pattern was positively related to serum triglycerides (r = 0.12, P = 0.002), a shift in the subclass distribution of VLDL toward larger particles (r = 0.12 for VLDL size, P < 0.001) and LDL toward smaller particles (r = -0.15 for LDL size, P < 0.001). In addition, higher scores on this pattern were positively correlated with concentrations of small, dense HDL (r = 0.16, P < 0.001). Habitual fish intake associated negatively with VLDL particle diameter ("Fish" pattern and biomarker) and positively with HDL particle diameter (biomarker). Our results suggest that in young adults, higher habitual fish consumption is related to favorable subclass distributions of VLDL and HDL, while junk food intake is associated with unfavorable alterations in the distribution of all lipoprotein subclasses independent of adiposity and other lifestyle factors. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Variability in HOMA-IR, Lipoprotein Profile and Selected Hormones in Young Active Men

    PubMed Central

    Lutoslawska, Grazyna; Czajkowska, Anna; Tkaczyk, Joanna; Mazurek, Krzysztof

    2013-01-01

    Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present study attempted to asses insulin resistance and its metabolic effects with respect to energy intake in young, lean, and active men. A total of 87 men aged 18–23 participated in the study. Plasma levels of glucose, insulin, lipoproteins, cortisol, and TSH were determined. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and calculated using homeostatic model. The median value of HOMA-IR (1.344) was used to divide subjects into two groups. Men did not differ in anthropometric parameters, daily physical activity, and plasma TSH and cortisol levels. However, in men with higher HOMA-IR significantly lower daily energy intake was observed concomitantly with higher TG, TC, and HDL-C concentrations in plasma versus their counterparts with lower HOMA-IR. Exclusively in subjects with higher HOMA-IR significant and positive correlation was noted between HOMA-IR and TC and LDL-C. We concluded that despite a normal body weight and physical activity, a subset of young men displayed unfavorable changes in insulin sensitivity and lipid profile, probably due to insufficient energy intake. PMID:24348155

  1. Risk factor profiles among intravenous drug using young adults: a latent class analysis (LCA) approach.

    PubMed

    James, Sigrid; McField, Edward S; Montgomery, Susanne B

    2013-03-01

    Using data from a cross-sectional study that examined health risk behaviors among urban intravenous drug-using (IDU) adolescents and young adults, this study investigated risk profiles among a high-risk sample (n=274). Risk profiles were empirically derived through latent class analysis based on indicators of engagement in health-risking behaviors, experience of abuse and violence as well as individual and family risk factors. The best fitting model was a 3-class model. Class 1 (n=95) captured participants with the lowest risk across all indicators. Compared to Class 1, Class 2 (n=128) and Class 3 (n=51) had elevated rates of engagement in health-risking behaviors as well as individual and family risk factors; however, Class 3 had the highest rate of engagement in sexual risk behavior, and backgrounds of substantial abuse and violence as well as familial psychopathology. Class 2 was the group most socioeconomically disadvantaged, with the highest percentage of participants coming from poor backgrounds, spending the longest time homeless and working the fewest months. Identifying subgroups of IDU has the potential to guide the development of more targeted and effective strategies for prevention and treatment of this high-risk population. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Coping profiles of young Athletes in their everyday life: A three-wave two-month study.

    PubMed

    Martinent, Guillaume; Decret, Jean-Claude

    2015-01-01

    Young athletes in intensive training settings are confronted with a series of daily stressors although they have a smaller and less flexible coping repertoire than adults. Moreover, previous studies neglected the multivariate nature of coping. Therefore, the purpose of the current study was to first identify coping profiles of young athletes in response to daily stressors related to their competitive sport involvement. Second, the study examined: (a) if such profiles were similar across the three waves, (b) how many participants belonged to the same profile along the three waves, and (c) whether individuals from distinct profiles differed on burnout, stress, and recovery. One hundred and forty-seven young table-tennis players involved in intensive training settings completed the CICS, RESTQ-Sport, and ABQ three times during a 2-month period. Cluster analyses indicated three similar clusters across the three waves: task-oriented coping, distraction- and disengagement-oriented coping, and low coping profiles. The distribution of athletes significantly varied across waves. Burnout, stress, and recovery significantly differed across the coping profiles. Athletes from the task-oriented coping profile were characterized by the best psychological adjustment (high scores of recovery and low scores of stress and burnout). In contrast, athletes from the distraction- and disengagement-oriented coping profile were characterized by the worst psychological adjustment (high scores of stress and burnout and low scores of recovery). These findings highlighted that the coping profiles allow examining coping within a holistic approach, teasing out the complex associations with key outcomes, such as burnout, stress, and recovery.

  3. Biography Today: Profiles of People of Interest to Young Readers. World Leaders Series: Modern African Leaders. Volume 2.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This book provides biographical profiles of 16 leaders of modern Africa of interest to readers ages 9 and above and was created to appeal to young readers in a format they can enjoy reading and easily understand. Biographies were prepared after extensive research, and this volume contains a name index, a general index, a place of birth index, and…

  4. Schoolwork Engagement and Burnout among Finnish High School Students and Young Adults: Profiles, Progressions, and Educational Outcomes

    ERIC Educational Resources Information Center

    Tuominen-Soini, Heta; Salmela-Aro, Katariina

    2014-01-01

    Applying a person-centered approach, the primary aim of this study was to examine what profiles of schoolwork engagement and burnout (i.e., exhaustion, cynicism, inadequacy) can be identified in high school (N = 979) and among the same participants in young adulthood (ages ranging from 17 to 25). We also examined gender differences, group…

  5. Longitudinal Analyses of Expressive Language Development Reveal Two Distinct Language Profiles among Young Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Tek, Saime; Mesite, Laura; Fein, Deborah; Naigles, Letitia

    2014-01-01

    Although children with Autism spectrum disorders (ASD) show significant variation in language skills, research on what type(s) of language profiles they demonstrate has been limited. Using growth-curve analyses, we investigated how different groups of young children with ASD show increases in the size of their lexicon, morpho-syntactic production…

  6. Biography Today: Profiles of People of Interest to Young Readers. World Leaders Series: Environmental Leaders 2. Volume 3.

    ERIC Educational Resources Information Center

    Hillstrom, Kevin, Ed.; Hillstrom, Laurie, Ed.

    This book provides biographical profiles of 11 environmental leaders of interest to readers ages 9 and above and was created to appeal to young readers in a format they can enjoy reading and readily understand. Biographies were prepared after extensive research, and each volume contains a cumulative index, a general index, a place of birth index,…

  7. Schoolwork Engagement and Burnout among Finnish High School Students and Young Adults: Profiles, Progressions, and Educational Outcomes

    ERIC Educational Resources Information Center

    Tuominen-Soini, Heta; Salmela-Aro, Katariina

    2014-01-01

    Applying a person-centered approach, the primary aim of this study was to examine what profiles of schoolwork engagement and burnout (i.e., exhaustion, cynicism, inadequacy) can be identified in high school (N = 979) and among the same participants in young adulthood (ages ranging from 17 to 25). We also examined gender differences, group…

  8. Cytokine profiling of young overweight and obese female African American adults with prediabetes

    PubMed Central

    Lucas, Rudolf; Parikh, Samip J.; Sridhar, Supriya; Guo, De-Huang; Bhagatwala, Jigar; Dong, Yutong; Caldwell, Ruth; Mellor, Andrew; Caldwell, William; Zhu, Haidong; Dong, Yanbin

    2014-01-01

    Approximately 5–10% of subjects with prediabetes become diabetic every year. Inflammation is involved in the development of obesity-related type 2 diabetes (T2D). However, to date, the relationship between inflammation and prediabetes, defined by hemoglobin A1c (HbA1c) ≥ 5.7 and < 6.5%, remains largely unexplored, especially in African Americans. Therefore, in this study we examined a comprehensive panel of 13 cytokines involved in the inflammatory response in overweight/obese subjects with prediabetes. A total of 21 otherwise healthy, overweight/obese, young adult African American females with prediabetes, together with 20 matched overweight/obese controls, were selected for this study. Plasma cytokines were assessed by multiplex cytokine profiling. Plasma concentrations of interleukin (IL)-5, IL-6, IL-7, tumor necrosis factor-α (TNF-α), and granulocyte-monocyte colony-stimulating factor (GM-CSF) were significantly higher in the prediabetic group, as compared to the control group (all p < 0.05). Plasma concentrations of all the other cytokines, interferon-γ (IFN-γ), IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12p70 and IL-13, seemed to be elevated in the prediabetic group, but failed to reach statistical significances. Upon merging both groups, HbA1c was found to be positively correlated with IFN- γ, IL-1β, IL-2, IL-5, IL-7, IL-8, TNF-α and GM-CSF. This study demonstrates elevated levels of various pro-inflammatory cytokines in overweight/obese young subjects with prediabetes, which place them at higher risk of developing T2D and cardiovascular diseases. Our data also call for further investigations in animal models and population cohorts to establish the roles of a variety of pro-inflammatory cytokines in the early development of obesity-related T2D. PMID:23769592

  9. Effect of Ramadan intermittent fasting on selective fitness profile parameters in young untrained Muslim men

    PubMed Central

    Roy, Anindita Singha; Bandyopadhyay, Amit

    2015-01-01

    Background The present study was aimed at investigating the effects of sleep deprivation and dietary irregularities during Ramadan intermittent fasting (RIF) on selective fitness profile parameters in young untrained male Muslim individuals. Methods 77 untrained Muslim men were recruited in the study. They were divided into the experimental group (EG; n=37, age: 22.62±1.77 years) and the control group (CG; n=40, age: 23.00±1.48 years). EG was undergoing RIF while CG abstained. Aerobic fitness, anaerobic capacity or high-intensity efforts (HIEs), agility, flexibility, vertical jump height and handgrip strength were measured on 8 separate occasions—15 days before RIF, 7 days before RIF, 1st day of RIF, 7th day of RIF, 15th day of RIF, 21st day of RIF, last day of RIF and 15 days after RIF. Results Aerobic fitness and HIE showed a significant difference (p<0.05) during RIF in EG. Agility and flexibility score showed a significant decrease in EG during RIF, whereas changes in the vertical jump score (VJT) and handgrip strength were statistically insignificant. Studied parameters showed an insignificant variation in CG during RIF. Aerobic fitness, HIEs, agility and flexibility showed a significant intergroup variation during different experimental trials. Conclusions The present investigation revealed that RIF had adverse effects on aerobic fitness, HIEs, agility and flexibility of young untrained Muslims of Kolkata, India. VJT, waist-hip ratio and handgrip strength were not affected by RIF in the studied population. Mild but statistically insignificant reduction in body mass was also reflected after the mid-Ramadan week. PMID:27900122

  10. Cytokine profiling of young overweight and obese female African American adults with prediabetes.

    PubMed

    Lucas, Rudolf; Parikh, Samip J; Sridhar, Supriya; Guo, De-Huang; Bhagatwala, Jigar; Dong, Yutong; Caldwell, Ruth; Mellor, Andrew; Caldwell, William; Zhu, Haidong; Dong, Yanbin

    2013-10-01

    Approximately 5-10% of subjects with prediabetes become diabetic every year. Inflammation is involved in the development of obesity-related type 2 diabetes (T2D). However, to date, the relationship between inflammation and prediabetes, defined by hemoglobin A1c (HbA1c) ≥5.7 and <6.5%, remains largely unexplored, especially in African Americans. Therefore, in this study we examined a comprehensive panel of 13 cytokines involved in the inflammatory response in overweight/obese subjects with prediabetes. A total of 21 otherwise healthy, overweight/obese, young adult African American females with prediabetes, together with 20 matched overweight/obese controls, were selected for this study. Plasma cytokines were assessed by multiplex cytokine profiling. Plasma concentrations of interleukin (IL)-5, IL-6, IL-7, tumor necrosis factor-α (TNF-α), and granulocyte-monocyte colony-stimulating factor (GM-CSF) were significantly higher in the prediabetic group, as compared to the control group (all p<0.05). Plasma concentrations of all the other cytokines, interferon-γ (IFN-γ), IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12p70 and IL-13, seemed to be elevated in the prediabetic group, but failed to reach statistical significances. Upon merging both groups, HbA1c was found to be positively correlated with IFN-γ, IL-1β, IL-2, IL-5, IL-7, IL-8, TNF-α and GM-CSF. This study demonstrates elevated levels of various pro-inflammatory cytokines in overweight/obese young subjects with prediabetes, which place them at higher risk of developing T2D and cardiovascular diseases. Our data also call for further investigations in animal models and population cohorts to establish the roles of a variety of pro-inflammatory cytokines in the early development of obesity-related T2D.

  11. Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

    PubMed Central

    Kumar, Tarun; Ramalingam, Rangaraj; Nanjappa Manjunath, Chollenhalli

    2016-01-01

    Background Prevalence of acute coronary syndrome in young individuals is increasing progressively. Previous studies have focused on the analysis of risk factors and to some extent coronary angiographic profile in young vs. old patients with acute coronary syndrome, but no study compared the angiographic profile in young patients based on the type of acute coronary syndrome. So, this study was conducted to determine the differences in demographic and coronary angiographic profile of young patients with ST-elevated myocardial infarction (STEMI) vs. those with non-ST-elevated myocardial infarction (NSTEMI) or unstable angina (UA). Methods We retrospectively analyzed young patients (age <40 years) with acute coronary syndrome who underwent coronary angiography at Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India between April 2010 and March 2011. Coronary risk factor profile and angiographic features were compared between STEMI and NSTEMI/UA patients. Results Of 8,268 patients who underwent coronary angiography during the study period, 820 (~10%) were ≤40 year age. Of them, 611 exhibited STEMI and 209 exhibited NSTEMI/UA. Angiographic analysis revealed that single-vessel disease was significantly more common in the STEMI group (56.6% vs. 36.6% respectively; P<0.001) whereas triple-vessel disease was significantly more common in the NSTEMI/UA group (3.6% vs. 10.5% respectively; P<0.001). Conversely, left anterior descending coronary artery was more commonly involved in the STEMI group (55.3% vs. 40.2% respectively; P<0.001), whereas left circumflex coronary artery was more commonly involved in the NSTEMI/UA group (11.8 vs. 23.4% respectively; P<0.001). Of note, smoking/tobacco consumption was the most significant coronary risk factor with prevalence as high as 65% in both groups. Conclusions In the present study, significant differences were observed in coronary risk factor profile and angiographic features between young patients with

  12. [Profile of free fatty acids (FFA) in serum of young Colombians with obesity and metabolic syndrome].

    PubMed

    Bermudez, J A; Velásquez, C M

    2014-12-01

    Obesity produces greater circulation of free fatty acids (FFA). In adults, the FFA composition changes in states of obesity; in adolescents, the results are contradictory. This study compare the FFA profile of obese youth with and without Metabolic Syndrome (MetS) and explore the association between FFA and metabolic alterations of obesity and MetS. A cross-sectional study with 96 young people between 10 and 18 years old was divided into three groups: 1) obese youth with MetS, 2) obese youth without MetS; and 3) adequate weight (AW), matched according to age, gender, pubertal maturation and socioeconomic stratum. The nutritional status was classified according to the body-mass index (BMI), according to the World Health Organization 2007 (WHO, 2007); the waist circumference (WC), adiposity, lipid profile, highly-sensitive reactive C protein (hsRCP), glucose, insulin and insulin resistance (IR), according to the homeostatic model assessment (HOMA Calculator Version 2.2.2). The FFA serum concentration was determined by gas chromatography. Both obese groups had higher adiposity, inflamation (hsRCP), FFA totals and frequency palmitoleic-16:Jn7, compared to AW. The obese with MetS presented more metabolic alterations, a greater amount of dihomo-γ-linolenic (DHGL-20:3n6) and a 20:3n6/18:2n6 relation, indicative of increased activity of A6 desaturase (D6D). The FFA totals, palmitoleic-l6:1n7, DHGL-20:3n6, D6D activity and hsRCP significantly correlated with variables of adiposity, IR and triglicerides. The results in obese with MetS corroborate the association among central obesity, inflammation and increased lipolysis in visceral adipose tissue and metabolic alterations.

  13. Physical activity and depression symptom profiles in young men and women with major depression.

    PubMed

    McKercher, Charlotte; Patton, George C; Schmidt, Michael D; Venn, Alison J; Dwyer, Terence; Sanderson, Kristy

    2013-05-01

    This study explored whether young adults with major depression who are physically active differ in their depression symptom profile from those physically inactive. Analyses included data from 950 (47.6%) men and 1045 women (mean [standard deviation] age = 31.5 [2.6] years) participating in a national study. Participants reported leisure physical activity (International Physical Activity Questionnaire) and ambulatory activity (pedometer steps per day). Diagnosis and symptoms of major depression were assessed using the Composite International Diagnostic Interview. Prevalence of major depression was 5.5% (n = 52) for men and 11.6% (n = 121) for women. Interactions between physical activity and sex were observed for depressed mood, appetite changes, vacillating thoughts, and suicidality (all, p < .050). Among those with major depression, physically active men were significantly less likely to endorse the presence of insomnia (prevalence ratio [PR] = 0.78, 95% confidence interval [CI] = 0.63-0.96), fatigue (PR = 0.82, 95% CI = 0.69-0.99), and suicidality (PR = 0.69, 95% CI = 0.49-0.96) compared with inactive men. Physically active women were significantly less likely to endorse hypersomnia (PR = 0.50, 95% CI = 0.27-0.95), excessive/irrational guilt (PR = 0.76, 95% CI = 0.59-0.97), vacillating thoughts (PR = 0.74, 95% CI = 0.58-0.95), and suicidality (PR = 0.43, 95% CI = 0.20-0.89) compared with inactive women. Associations were adjusted for age, physical health, educational attainment, depression severity, and other depressive symptoms. Among adults with major depression, those physically active seem to differ in their depression symptom profile from those physically inactive.

  14. Award for Distinguished Scientific Contributions: Terrie E. Moffitt and Avshalom Caspi.

    PubMed

    2016-11-01

    The APA Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. Two of the 2016 award winners are Terrie E. Moffitt and Avshalom Caspi, who received this shared award for "innovative research and theory on mental health and human development," in which they have demonstrated "how early life experiences shape health disparities and how genetic factors shape and are shaped by environmental factors." Moffitt's and Caspi's shared award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  15. Design, construction, and first season's operation of M. V. Kalvik and M. V. Terry Fox

    SciTech Connect

    Browne, R.P.; Carter, J.E.; Kimmerly, P.C.

    1984-05-01

    This paper describes the design, construction and first season's operation of the sister ships M. V. Kalvik and M.V. Terry Fox, the most powerful privately owned icebreakers in the world. These multi-purpose Arctic Class IV vessels are designed to support BeauDril Limited's Arctic Drilling Units in the areas of ice management, towing, anchor handling and supply. In order to achieve the required exceptional icebreaking capability and flexibility of operation, a specific combination of design features was selected. The first season's experience with the vessels, including ice trials, has shown that their performance meets and in most aspects exceeds the design requirements.

  16. Terri Schiavo: the assessment of the persistent vegetative state in accordance with German law.

    PubMed

    Becker-Schwarze, Kathrin

    2005-12-01

    The case of Terri Schiavo in the USA served to intensify the debate in Germany which itself had in part already been characterised by fundamentalism. Now that some time has elapsed and the political debate has quietened, this case is to be taken up again in discussing the permissibility and the prerequisites of passive euthanasia for patients in a persistent vegetative state. A short reconstruction of the facts of the case (II) is to be followed by a survey of the case law of the Criminal Panels (III) which is essential to understand the present legal policy debate to be discussed at a later stage (IV).

  17. Distinctive Rorschach profiles of young adults with schizophrenia and autism spectrum disorder

    PubMed Central

    Kishimoto, Naoko; Yamamuro, Kazuhiko; Iida, Junzo; Ota, Toyosaku; Tanaka, Shohei; Kyo, Masanori; Kimoto, Sohei; Kishimoto, Toshifumi

    2016-01-01

    Objective The differential diagnosis of schizophrenia (SZ) versus autism spectrum disorder (ASD) can be clinically challenging because accumulating evidence suggests both clinical and biological overlaps between them. The aim of this study was to compare Rorschach profiles between young adults with SZ and those with ASD. Methods We evaluated quantitative tendencies on the Rorschach test among 20 patients diagnosed with SZ and 20 diagnosed with ASD. Both groups were matched for age, sex, and intelligence quotient. Results We found significant differences in six response variables on the Rorschach comprehensive system. Those with SZ had significantly higher scores on D score, adjusted D score (Adj D), developmental quality code reflecting ordinary response (DQo), and form quality minus (FQ −) than those with ASD. In contrast, those with SZ had significantly lower scores on the active and developmental quality code reflecting synthesized response (DQ+) subscales than those with ASD. Conclusion The present findings reveal that individuals with SZ might have more stress tolerance, stronger perception distortions, and simpler and poorer recognition than those with ASD. We suggest that the Rorschach test might be a useful tool for differentiating between SZ and ASD. PMID:27703357

  18. Effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults.

    PubMed

    Wahrburg, U; Martin, H; Schulte, H; Walek, T; Assmann, G

    1994-03-01

    To investigate the effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults. Randomized controlled study with three study groups and a parallel design, consisting of two consecutive periods. Outpatient clinical research center in a university clinic. 119 healthy students (60 male, 59 female) who were selected after a screening. All completed the study. Blood samples of three subjects (1 male, 2 female) were excluded from evaluation due to later diagnosed genetic anomalies of lipid metabolism. All subjects consumed 750-1000 ml of caffeinated filtered coffee per day for a 2 week wash-in period. During the 6 week test period one group continued drinking the caffeinated coffee, while the two other groups consumed different kinds of decaffeinated coffee. Consumption of both types of decaffeinated coffee did not lead to any significant changes in serum total and LDL cholesterol, triglycerides and apolipoprotein B. Furthermore, there were no significant differences in the reactions between the three groups. The diet did not change during the study. Switch from regular to decaffeinated coffee had no cholesterol-elevating effects, irrespective of the type of coffee.

  19. Lipoprotein subclass profiles in young adults born preterm at very low birth weight.

    PubMed

    Hovi, Petteri; Kajantie, Eero; Soininen, Pasi; Kangas, Antti J; Järvenpää, Anna-Liisa; Andersson, Sture; Eriksson, Johan G; Ala-Korpela, Mika; Wehkalampi, Karoliina

    2013-04-30

    Adults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse. We studied 162 subjects born at VLBW and 169 term-born controls, aged 19 to 27 years. Total lipid, triglyceride and cholesterol concentrations of 14 lipoprotein subclasses were determined by proton nuclear magnetic resonance spectroscopy in the fasting state and in 2-hour serum samples from an oral glucose tolerance test. In comparison to controls, VLBW subjects had significantly higher fasting concentration of triglycerides in chylomicrons and largest very-low-density lipoprotein particles [XXL-VLDL-TG, difference 0.026 (95% CI: 0.004 to 0.049), P=0.024], and of triglycerides in small high-density lipoprotein particles [S-HDL-TG, 0.026 (95% CI: 0.002 to 0.051), P=0.037]. The seemingly important role of triglycerides was further supported by principal component analysis in which the first component was characterized by multiple lipoprotein triglyceride measures. Young adults born at VLBW and their peers born at term had triglyceride-related differences in both VLDL and HDL subclasses. These differences suggest that the increased risk factors for cardiovascular diseases among the VLBW individuals in adulthood may partly relate to impaired triglyceride metabolism.

  20. Socio-cognitive profiles for visual learning in young and older adults

    PubMed Central

    Christian, Julie; Goldstone, Aimee; Kuai, Shu-Guang; Chin, Wynne; Abrams, Dominic; Kourtzi, Zoe

    2015-01-01

    It is common wisdom that practice makes perfect; but why do some adults learn better than others? Here, we investigate individuals’ cognitive and social profiles to test which variables account for variability in learning ability across the lifespan. In particular, we focused on visual learning using tasks that test the ability to inhibit distractors and select task-relevant features. We tested the ability of young and older adults to improve through training in the discrimination of visual global forms embedded in a cluttered background. Further, we used a battery of cognitive tasks and psycho-social measures to examine which of these variables predict training-induced improvement in perceptual tasks and may account for individual variability in learning ability. Using partial least squares regression modeling, we show that visual learning is influenced by cognitive (i.e., cognitive inhibition, attention) and social (strategic and deep learning) factors rather than an individual’s age alone. Further, our results show that independent of age, strong learners rely on cognitive factors such as attention, while weaker learners use more general cognitive strategies. Our findings suggest an important role for higher-cognitive circuits involving executive functions that contribute to our ability to improve in perceptual tasks after training across the lifespan. PMID:26113820

  1. Lipid profiling of follicular fluid from women undergoing IVF: young poor ovarian responders versus normal responders.

    PubMed

    Cataldi, Thais; Cordeiro, Fernanda Bertuccez; Costa, Lívia do Vale Teixeira da; Pilau, Eduardo Jorge; Ferreira, Christina Ramires; Gozzo, Fábio Cesar; Eberlin, Marcos Nogueira; Bertolla, Ricardo Pimenta; Cedenho, Agnaldo Pereira; Turco, Edson Guimarães Lo

    2013-12-01

    This study identified possible lipid biomarkers in follicular fluid from women with poor ovarian response. These biomarkers indicate pathophysiological pathways and have potential diagnostic applications. An observational case-control study of young women undergoing ovarian stimulation for in-vitro fertilization was conducted. The participants were categorized into a poor ovarian response group and a normal ovarian response to stimulation group. All of the women underwent the same ovarian stimulation protocol, and follicular fluid was collected after ovarian aspiration. Analyses were performed using matrix-assisted laser desorption/ionization mass spectrometry. Principal component analysis and Volcano plots were used to describe follicular fluid classification models based on the lipid profiles. A total of 10 lipids were differentially expressed between the study and control groups. Of these lipid ions, three belonged to the phosphatidylcholine subclass and were present in higher concentrations in the control group. The other seven differential lipids were present in the study group and classified into four lipid subclasses: phosphatidylethanolamines, phosphatidylglycerols, phosphatidylinositols, and diacylglycerols. These distinctive lipids may be involved in hormonal responses and oocyte development processes and may be useful as biomarkers for therapeutic intervention in women with poor ovarian response.

  2. Profiling of smokers and snuffers among young Finnish men - cross-sectional epidemiological study().

    PubMed

    Päkkilä, Jari; Anttonen, Vuokko; Patinen, Pertti; Nyman, Kai; Valkeapää, Kirsi; Birkhed, Dowen; Tjäderhane, Leo; Tanner, Tarja

    2017-08-08

    The purpose of this study was to get new information from several sources about the background factors of Finnish smokers, snuffers, and dual users. Profiles of young smokers and snuffers were investigated in association with restorative treatment need, oral hygiene, eating habits, physical activity, body mass index (BMI), psychological and socioeconomic factors. The study group comprised 3420 conscripts. The data were collected from four different sources: a health examination including an oral health screening, a computer-based questionnaire for investigating individual background factors, a psychological test assessing cognitive skills, and the Cooper test. Statistical analyses comprised cross tabulation and binary logistic regression modelling. The odds for smoking were the greatest among those who had DT (Decayed teeth) > 0, used energy drinks or alcohol regularly, or whose parents were divorced. A score of ≥2900 m in the Cooper test, a higher physical exercise level, a higher own education level, and using sports drinks decreased the odds for smoking. The odds for snuffing were higher among those who ran >2500 m in the Cooper test, had a BMI of ≥25, used sports/energy drinks, or exercised regularly, and lower among those who achieved good results in the cognitive test. Using energy/sports drinks or alcohol was positively and a higher education level was negatively associated with dual use. Along with increasing prevalence of snuffing, heterogeneity is likely among snuffers. Good cognitive skills may prevent from smoking and snuffing.

  3. Distinctive Rorschach profiles of young adults with schizophrenia and autism spectrum disorder.

    PubMed

    Kishimoto, Naoko; Yamamuro, Kazuhiko; Iida, Junzo; Ota, Toyosaku; Tanaka, Shohei; Kyo, Masanori; Kimoto, Sohei; Kishimoto, Toshifumi

    2016-01-01

    The differential diagnosis of schizophrenia (SZ) versus autism spectrum disorder (ASD) can be clinically challenging because accumulating evidence suggests both clinical and biological overlaps between them. The aim of this study was to compare Rorschach profiles between young adults with SZ and those with ASD. We evaluated quantitative tendencies on the Rorschach test among 20 patients diagnosed with SZ and 20 diagnosed with ASD. Both groups were matched for age, sex, and intelligence quotient. We found significant differences in six response variables on the Rorschach comprehensive system. Those with SZ had significantly higher scores on D score, adjusted D score (Adj D), developmental quality code reflecting ordinary response (DQo), and form quality minus (FQ -) than those with ASD. In contrast, those with SZ had significantly lower scores on the active and developmental quality code reflecting synthesized response (DQ+) subscales than those with ASD. The present findings reveal that individuals with SZ might have more stress tolerance, stronger perception distortions, and simpler and poorer recognition than those with ASD. We suggest that the Rorschach test might be a useful tool for differentiating between SZ and ASD.

  4. Biography Today: Profiles of People of Interest to Young Readers, 1999.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    1999-01-01

    This document is the eighth volume of a series designed and written for the young reader aged 9 and above. It contains three issues and covers individuals whom young people want to know about most: entertainers, athletes, writers, illustrators, cartoonists, and political leaders. The publication was created to appeal to young readers in a format…

  5. Biography Today: Profiles of People of Interest to Young Readers, 1994.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.

    1994-01-01

    This document is the third volume of a series designed and written for the young reader aged 9 and above. It contains three issues and covers individuals that young people want to know about most: entertainers, athletes, writers, illustrators, cartoonists, and political leaders. The publication was created to appeal to young readers in a format…

  6. Segmenting by Risk Perceptions: Predicting Young Adults’ Genetic-Belief Profiles with Health and Opinion-Leader Covariates

    PubMed Central

    Smith, Rachel A.; Greenberg, Marisa; Parrott, Roxanne L.

    2014-01-01

    With a growing interest in using genetic information to motivate young adults’ health behaviors, audience segmentation is needed for effective campaign design. Using latent class analysis, this study identifies segments based on young adults’ (N = 327) beliefs about genetic threats to their health and personal efficacy over genetic influences on their health. A four-class model was identified. The model indicators fit the risk perception attitude framework (Rimal & Real, 2003), but the covariates (e.g., current health behaviors) did not. In addition, opinion leader qualities covaried with one profile: those in this profile engaged in fewer preventative behaviors and more dangerous treatment options, and also liked to persuade others, making them a particularly salient group for campaign efforts. The implications for adult-onset disorders, like alpha-1 antitrypsin deficiency are discussed. PMID:24111749

  7. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    SciTech Connect

    Houseworth, Jim; Rutqvist, Jonny; Asahina, Daisuke; Chen, Fei; Vilarrasa, Victor; Liu, Hui-Hai; Birkholzer, Jens

    2013-11-01

    Nuclear waste programs outside of the US have focused on different host rock types for geological disposal of high-level radioactive waste. Several countries, including France, Switzerland, Belgium, and Japan are exploring the possibility of waste disposal in shale and other clay-rich rock that fall within the general classification of argillaceous rock. This rock type is also of interest for the US program because the US has extensive sedimentary basins containing large deposits of argillaceous rock. LBNL, as part of the DOE-NE Used Fuel Disposition Campaign, is collaborating on some of the underground research laboratory (URL) activities at the Mont Terri URL near Saint-Ursanne, Switzerland. The Mont Terri project, which began in 1995, has developed a URL at a depth of about 300 m in a stiff clay formation called the Opalinus Clay. Our current collaboration efforts include two test modeling activities for the FE heater test and the HG-A leak-off test. This report documents results concerning our current modeling of these field tests. The overall objectives of these activities include an improved understanding of and advanced relevant modeling capabilities for EDZ evolution in clay repositories and the associated coupled processes, and to develop a technical basis for the maximum allowable temperature for a clay repository.

  8. Structural and mechanical analysis of the Mont Terri Anticline (Jura, Switzerland)

    NASA Astrophysics Data System (ADS)

    Caer, Typhaine; Souloumiac, Pauline; Maillot, Bertrand; Leturmy, Pascale; Nussbaum, Christophe

    2014-05-01

    The main motivation of this study is to illustrate how geometrical constructions of geological structures can be constrained by mechanical equilibrium and the Coulomb criterion using the theory of limit analysis. In the NW deformation front of the Jura thrust belt in Switzerland, the Mont-Terri anticline is located at an interruption of the Muschelkalk décollement, due to former normal faults. It is characterised by a reversed frontal limb, a steep back limb, and a ramp cross-cutting some of the former normal faults. A borehole and a highway tunnel constrain the inner structure. Three 2D kinematics and present-day cross-sections are proposed as various combinations of fault-bend folds, fault propagation folds and detachment folds (one of them being the only previously published interpretation of Mont Terri). Each interpretation is tentatively tested with the external approach of limit analysis, leading to different compatible ranges of values of the frictional parameters and of their variation with progressive shortening. It is not possible to reject any interpretation with confidence. Furthermore, the exact evolution of the topography during shortening is largely unknown. It is shown by the mechanical analysis to play a very important role in selecting the locations and dips of the active faults because it imposes spatial variations of their loading. The merit of the present approach is therefore to provide a quantitative link between the assumed evolution of the internal structure, the topography, and the frictional parameters.

  9. Teams ranking of Malaysia Super League using Bayesian expectation maximization for Generalized Bradley Terry Model

    NASA Astrophysics Data System (ADS)

    Nor, Shahdiba Binti Md; Mahmud, Zamalia

    2016-10-01

    The analysis of sports data has always aroused great interest among statisticians and sports data have been investigated from different perspectives often aim at forecasting the results. The study focuses on the 12 teams who join the Malaysian Super League (MSL) for season 2015. This paper used Bayesian Expectation Maximization for Generalized Bradley Terry Model to estimate all the football team's rankings. The Generalized Bradley-Terry model is possible to find the maximum likelihood (ML) estimate of the skill ratings λ using a simple iterative procedure. In order to maximize the function of ML, we need inferential bayesian method to get posterior distribution which can be computed quickly. The team's ability was estimated based on the previous year's game results by calculating the probability of winning based on the final scores for each team. It was found that model with tie scores does make a difference in affect the model of estimating the football team's ability in winning the next match. However, team with better results in the previous year has a better chance for scoring in the next game.

  10. Anthropometric profiles of elite older triathletes in the Ironman Brazil compared with those of young Portuguese triathletes and older Brazilians.

    PubMed

    Silva, Diego A S; Benedetti, Tânia R B; Ferrari, Elisa P; Meurer, Simone T; Antes, Danielle L; Silva, Analiza M; Santos, Diana A; Matias, Catarina N; Sardinha, Luís B; Vieira, Filomena; Petroski, Edio L

    2012-01-01

    The objective of this study was to describe the anthropometric profiles of elite older triathletes participating in the 2009 Ironman Brazil and to compare their somatotype, anthropometric and body composition characteristics with those of elite young triathletes and older non-athletes. The sample consisted of 64 males, divided into three groups: (1) older triathletes (n = 17), (2) young triathletes (n = 24), and (3) older non-athletes (n = 23). Somatotype was analysed according to the Carter and Heath ( 1990 ) method. Body mass index, sum of four skinfolds, percentage body fat, body fat mass, and fat-free mass were also estimated. Older non-athletes had higher endomorphy, sum of four skinfolds, fat percentage, and body fat mass than the athletes. Older athletes who participated in the Ironman and elite young triathletes had higher fat-free mass than older non-athletes. Older triathletes and older non-athletes were considered mainly endomorphic mesomorphs and young triathletes mainly ectomorphic mesomorphs. The findings that characterize the anthropometric profile of athletes in this sports modality could be used as a reference.

  11. Lipoprotein subclass profiles in young adults born preterm at very low birth weight

    PubMed Central

    2013-01-01

    Background Adults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse. Subjects and methods We studied 162 subjects born at VLBW and 169 term-born controls, aged 19 to 27 years. Total lipid, triglyceride and cholesterol concentrations of 14 lipoprotein subclasses were determined by proton nuclear magnetic resonance spectroscopy in the fasting state and in 2-hour serum samples from an oral glucose tolerance test. Findings In comparison to controls, VLBW subjects had significantly higher fasting concentration of triglycerides in chylomicrons and largest very-low-density lipoprotein particles [XXL-VLDL-TG, difference 0.026 (95% CI: 0.004 to 0.049), P = 0.024], and of triglycerides in small high-density lipoprotein particles [S-HDL-TG, 0.026 (95% CI: 0.002 to 0.051), P = 0.037]. The seemingly important role of triglycerides was further supported by principal component analysis in which the first component was characterized by multiple lipoprotein triglyceride measures. Conclusions Young adults born at VLBW and their peers born at term had triglyceride-related differences in both VLDL and HDL subclasses. These differences suggest that the increased risk factors for cardiovascular diseases among the VLBW individuals in adulthood may partly relate to impaired triglyceride metabolism. PMID:23631373

  12. Extremely eroded or incredibly young - 10Be depth profile dating of moraines in the Swiss Midlands

    NASA Astrophysics Data System (ADS)

    Wüthrich, Lorenz; Zech, Roland; Haghipour, Negar; Gnägi, Christian; Christl, Markus; Ivy-Ochs, Susan; Veit, Heinz

    2014-05-01

    During the Pleistocene, glaciers advanced repeatedly from the Alps into the Swiss Midlands. The exact extent and timing are still under debate, even for the last glacial advances. Decalcification depths, for example, increase from west to east in the western Swiss Midlands and have been interpreted to indicate that the Valais (Rhone) glacier may have been less extensive during the global Last Glacial Maximum (LGM) at 20 ka than assumed so far [1]. In an attempt to provide more quantitative age control, we applied 10Be depth profile dating [2] on moraines at two locations. Steinhof has previously been dated to the global LGM based on exposure ages from four boulders [3], and Niederbuchsiten presumably lies outside the last glacial ice extent [1]. The 10Be concentrations at both sites decrease consistently with depth, but are very similar. Assuming only a few decimeters of erosion since moraine deposition, we obtain apparent exposure ages of ~20 ka. Niederbuchsiten would thus be unexpectedly young, implying a much more extensive extent of the LGM glacier than assumed so far. Alternatively, if the till at Niederbuchsiten was deposited during or before the penultimate glaciation (>130 ka), the surprisingly low 10Be concentrations indicate several meters of erosion during the last glacial cycle and/or the Holocene, which seems to be at odds with the deep and intensive soil formation. References: [1] Bitterli et al. (2011) Geologischer Atlas der Schweiz, Blatt 1108. [2] Hidy et al. (2010) Geochem. Geophys. Geosyst. 11, doi:10.1029/2010GC003084. [3] Ivy- Ochs et al. (2004) Ecl. Geol. Helv. 97, 47-55.

  13. Young

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Astronaut John W. Young, commander of the Apollo 16 lunar landing mission, jumps up from the lunar surface as he salutes the U.S. Flag at the Descartes landing site during the first Apollo 16 extravehicular activity (EVA-1). Astronaut Charles M. Duke Jr., lunar module pilot, took this picture. The Lunar Module (LM) 'Orion' is on the left. The Lunar Roving Vehicle is parked beside the LM. The object behind Young in the shade of the LM is the Far Ultraviolet Camera/Spectrograph. Stone Mountain dominates the background in this lunar scene.

  14. Immunological profiling of haemodialysis patients and young healthy individuals with implications for clinical regulatory T cell sorting.

    PubMed

    Bergström, M; Joly, A-L; Seiron, P; Isringhausen, S; Modig, E; Fellström, B; Andersson, J; Berglund, D

    2015-05-01

    With the increasing interest in clinical trials with regulatory T cells (Tregs), immunological profiling of prospective target groups and standardized procedures for Treg isolation are needed. In this study, flow cytometry was used to assess peripheral blood lymphocyte profiles of young healthy individuals and patients undergoing haemodialysis treatment. Tregs obtained from the former may be used in haematopoietic stem cell transplantation and Tregs from the latter in the prevention of kidney transplant rejection. FOXP3 mRNA expression with accompanying isoform distribution was also assessed by the quantitative reverse transcriptase polymerase chain reaction. Flow-cytometric gating strategies were systematically analysed to optimize the isolation of Tregs. Our findings showed an overall similar immunological profile of both cohorts in spite of great differences in both age and health. Analysis of flow-cytometric gating techniques highlighted the importance of gating for both CD25high and CD127low expression in the isolation of FOXP3-positive cells. This study provides additional insight into the immunological profile of young healthy individuals and uraemic patients as well as in-depth analysis of flow-cytometric gating strategies for Treg isolation, supporting the development of Treg therapy using cells from healthy donors and uraemic patients.

  15. Profiles of Young Children Teacher-Identified as At Risk for Emotional Disturbance: A Pilot Study

    ERIC Educational Resources Information Center

    Trout, Alexandra L.; Epstein, Michael H.; Nelson, J. Ron; Reid, Robert; Ohlund, Barbara

    2006-01-01

    As prevention and early intervention opportunities for young children at risk of emotional disturbance (ED) increase, questions regarding the effectiveness of these programs for specific subpopulations of children have emerged. To date, few investigators have examined young children entering early school prevention/intervention programs to…

  16. Biography Today: Profiles of People of Interest to Young Readers, 1997.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    1997-01-01

    Comprising the sixth volume of a series, this document contains short biographies written for the young reader aged 9 and older. The series covers individuals who are of particular interest to young people: entertainers, athletes, authors, cartoonists, and political leaders. Each issue contains 10 to 12 entries that include photographs and…

  17. Biography Today: Profiles of People of Interest to Young Readers. General Series.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    2002-01-01

    This publication, which covers individuals that young readers want to know about most, entertainers, athletes, writers, illustrators, cartoonists, and political leaders, was especially created to appeal to young readers in a format where they can enjoy reading and can readily understand. Each issue contains approximately 10 sketches arranged…

  18. Biography Today: Profiles of People of Interest to Young Readers, 1998.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    1998-01-01

    This series is designed and written for young readers, aged 9 and above. The volumes cover individuals that young readers want to know most about, including entertainers, athletes, writers, illustrators, cartoonists, and political leaders. Each issue contains numerous sketches arranged alphabetically. Each entry provides at least one picture of…

  19. Microstructure and porosity of Opalinus Clay at the Mont Terri rock laboratory (Switzerland)

    NASA Astrophysics Data System (ADS)

    Houben, M. E.; Laurich, B.; Desbois, G.; Urai, J. L.

    2012-04-01

    The Mont Terri rock laboratory (Canton Jura, Switzerland) is an international scientific platform of research on radioactive waste disposal in Opalinus Clay and results provide input for assessing the feasibility and safety of deep geological disposal of radioactive waste in argillaceous formations [1]. A main safety issue is to accurately investigate mass transport rates. To date several methods analyzed bulk permeability and porosity of Opalinus Clay. However, detailed quantitative investigation of microstructure and pore morphology is necessary to understand sealing capacity, coupled flow, capillary processes and associated deformation. To produce high quality cross-sections without microstructural damage that enable investigation of microstructure and porosity down the nm scale a combination of Broad Ion Beam (BIB) milling and SEM imaging has been used [2]. This method allowed direct imaging of the clay fabric and porosity on ca. 1 mm2 areas. The lateral variability of Opalinus Clay is low on the regional scale [1], whereas vertically the Opalinus Clay can be subdivided into six different lithological subfacies [3] based on variable silt layers, sandstone layers and siderite concretions present, where the end-members are the Shaly and Sandy facies. In this contribution microstructures and pore space in Opalinus Clay from the undisturbed Shaly and Sandy facies are studied and compared to disturbed samples from the "Main fault" within the Mont Terri rock laboratory. The Shaly facies in the lower half of the sequence constitutes of dark grey silty calcerous shales and argillaceous marls, whereas the Sandy facies comprises silty to sandy marls with sandstone lenses cemented with carbonate [3]. The qualitative mineralogical composition of all Opalinus Clay facies is similar, whereas the "Main Fault" shows calcite, celestite and pyrite veins. Although the overall microfabric differs per layer and per facies we observe low variability of microstructure and porosity in

  20. Geological modeling of a fault zone in clay rocks at the Mont-Terri laboratory (Switzerland)

    NASA Astrophysics Data System (ADS)

    Kakurina, M.; Guglielmi, Y.; Nussbaum, C.; Valley, B.

    2016-12-01

    Clay-rich formations are considered to be a natural barrier for radionuclides or fluids (water, hydrocarbons, CO2) migration. However, little is known about the architecture of faults affecting clay formations because of their quick alteration at the Earth's surface. The Mont Terri Underground Research Laboratory provides exceptional conditions to investigate an un-weathered, perfectly exposed clay fault zone architecture and to conduct fault activation experiments that allow explore the conditions for stability of such clay faults. Here we show first results from a detailed geological model of the Mont Terri Main Fault architecture, using GoCad software, a detailed structural analysis of 6 fully cored and logged 30-to-50m long and 3-to-15m spaced boreholes crossing the fault zone. These high-definition geological data were acquired within the Fault Slip (FS) experiment project that consisted in fluid injections in different intervals within the fault using the SIMFIP probe to explore the conditions for the fault mechanical and seismic stability. The Mont Terri Main Fault "core" consists of a thrust zone about 0.8 to 3m wide that is bounded by two major fault planes. Between these planes, there is an assembly of distinct slickensided surfaces and various facies including scaly clays, fault gouge and fractured zones. Scaly clay including S-C bands and microfolds occurs in larger zones at top and bottom of the Mail Fault. A cm-thin layer of gouge, that is known to accommodate high strain parts, runs along the upper fault zone boundary. The non-scaly part mainly consists of undeformed rock block, bounded by slickensides. Such a complexity as well as the continuity of the two major surfaces are hard to correlate between the different boreholes even with the high density of geological data within the relatively small volume of the experiment. This may show that a poor strain localization occurred during faulting giving some perspectives about the potential for

  1. The Origin of The Piz Terri-Lunschania zone (Central Alps, Switzerland)

    NASA Astrophysics Data System (ADS)

    Galster, Federico; Stockli, Daniel

    2017-04-01

    The Piz Terri-Lunschania zone (PTLZ) represents a band of metasedimentary rocks embedded in a crucial knot at the NE border of the Lepontine dome, at the intersection of the Gotthard, Lucomagno, Simano, Adula and Grava nappes. Its origin and its position in the tectonostratigraphy of the Central Alps are still not completely understood. A better understanding of this sedimentary zone and its tectonic position could shed lights on the Helvetic-Penninic connection and facilitate the disentanglement of the Lepontine dome tectonics. In this study we combine structural and stratigraphic observations with detrital zircon (DZ) and detrital rutile (DR) U-Pb geochronology as well as mineral trace element data from Permian, Triassic and Jurassic sandstones. We compare these data with those from adjacent tectonic units and coeval strata in other portions of the Alpine chain. Maximal depositional ages, abrupt changes in provenances and stratigraphic correlations based on new DZ and DR U-Pb and trace element data allow for a better understanding of the sedimentary evolution of the Terri basin and its palaeogeographic position along the northern margin of the Alpine Tethys. In particular the DZ U-Pb signatures, with its abundant 260-280 Ma zircons and the scarcity of 290-350 Ma zircons, corroborates an Ultra-Adula origin of the PTLZ as proposed by Galster et al (2010; 2012) based on stratigraphic arguments and reinforces the notion of a Briançonnais influence on the stratigraphic record of this complex zone, a fact that has important tectonic and Palaeogeographic implications. Galster F, Cavargna-Sani M, Epard J-L, Masson H (2012) New stratigraphic data from the Lower Penninic between the Adula nappe and the Gotthard massif and consequences for the tectonics and the paleogeography of the Central Alps. Tectonophysics 579:37-55. doi: 10.1016/j.tecto.2012.05.029 Galster F, Epard J-L, Masson H (2010) The Soja and Luzzone-Terri nappes: Discovery of a Briançonnais element below the

  2. How Do Young Students with Different Profiles of Reading Skill Mastery, Perceived Ability, and Goal Orientation Respond to Holistic Diagnostic Feedback?

    ERIC Educational Resources Information Center

    Jang, Eunice Eunhee; Dunlop, Maggie; Park, Gina; van der Boom, Edith H.

    2015-01-01

    One critical issue with cognitive diagnostic assessment (CDA) lies in its lack of research evidence that shows how diagnostic feedback from CDA is interpreted and used by young students. This mixed methods research examined how holistic diagnostic feedback (HDF) is processed by young learners with different profiles of reading skills, goal…

  3. How Do Young Students with Different Profiles of Reading Skill Mastery, Perceived Ability, and Goal Orientation Respond to Holistic Diagnostic Feedback?

    ERIC Educational Resources Information Center

    Jang, Eunice Eunhee; Dunlop, Maggie; Park, Gina; van der Boom, Edith H.

    2015-01-01

    One critical issue with cognitive diagnostic assessment (CDA) lies in its lack of research evidence that shows how diagnostic feedback from CDA is interpreted and used by young students. This mixed methods research examined how holistic diagnostic feedback (HDF) is processed by young learners with different profiles of reading skills, goal…

  4. "We Cooperate, or We Die": Sustainable Coexistence in Terry Pratchett's "The Amazing Maurice" and "His Educated Rodents"

    ERIC Educational Resources Information Center

    Oziewicz, Marek

    2009-01-01

    This article examines Terry Pratchett's "The Amazing Maurice" as a modern example of environmentally informed social dreaming about sustainable coexistence. In our increasingly ecologically-conscious world sustainability and coexistence have become key words in the discourse about social, economic and political relations. The problem of relating…

  5. "We Cooperate, or We Die": Sustainable Coexistence in Terry Pratchett's "The Amazing Maurice" and "His Educated Rodents"

    ERIC Educational Resources Information Center

    Oziewicz, Marek

    2009-01-01

    This article examines Terry Pratchett's "The Amazing Maurice" as a modern example of environmentally informed social dreaming about sustainable coexistence. In our increasingly ecologically-conscious world sustainability and coexistence have become key words in the discourse about social, economic and political relations. The problem of relating…

  6. Development and Implementation of Mechanistic Terry Turbine Models in RELAP-7 to Simulate RCIC Normal Operation Conditions

    SciTech Connect

    Zhao, Haihua; Zou, Ling; Zhang, Hongbin; O'Brien, James Edward

    2016-09-01

    As part of the efforts to understand the unexpected “self-regulating” mode of the RCIC (Reactor Core Isolation Cooling) systems in Fukushima accidents and extend BWR RCIC and PWR AFW (Auxiliary Feed Water) operational range and flexibility, mechanistic models for the Terry turbine, based on Sandia’s original work [1], have been developed and implemented in the RELAP-7 code to simulate the RCIC system. In 2016, our effort has been focused on normal working conditions of the RCIC system. More complex off-design conditions will be pursued in later years when more data are available. In the Sandia model, the turbine stator inlet velocity is provided according to a reduced-order model which was obtained from a large number of CFD (computational fluid dynamics) simulations. In this work, we propose an alternative method, using an under-expanded jet model to obtain the velocity and thermodynamic conditions for the turbine stator inlet. The models include both an adiabatic expansion process inside the nozzle and a free expansion process outside of the nozzle to ambient pressure. The combined models are able to predict the steam mass flow rate and supersonic velocity to the Terry turbine bucket entrance, which are the necessary input information for the Terry turbine rotor model. The analytical models for the nozzle were validated with experimental data and benchmarked with CFD simulations. The analytical models generally agree well with the experimental data and CFD simulations. The analytical models are suitable for implementation into a reactor system analysis code or severe accident code as part of mechanistic and dynamical models to understand the RCIC behaviors. The newly developed nozzle models and modified turbine rotor model according to the Sandia’s original work have been implemented into RELAP-7, along with the original Sandia Terry turbine model. A new pump model has also been developed and implemented to couple with the Terry turbine model. An input

  7. Tailoring in risk communication by linking risk profiles and communication preferences: The case of speeding of young car drivers.

    PubMed

    Geber, Sarah; Baumann, Eva; Klimmt, Christoph

    2016-12-01

    Speeding is one of the most relevant risk behaviors for serious and fatal accidents, particularly among young drivers. This study presents a tailoring strategy for anti-speeding communication. By referring to their motivational dispositions toward speeding derived from motivational models of health behavior, young car drivers were segmented into different risk groups. In order to ensure that risk communication efforts would actually be capable to target these groups, the linkage between the risk profiles and communication preferences were explored. The study was conducted on the basis of survey data of 1168 German car drivers aged between 17 and 24 years. The data reveal four types of risk drivers significantly differing in their motivational profiles. Moreover, the findings show significant differences in communication habits and media use between these risk groups. By linking the risk profiles and communication preferences, implications for tailoring strategies of road safety communication campaigns are derived. Promising segmentation and targeting strategies are discussed also beyond the current case of anti-speeding campaigns.

  8. The Functional Profile of Young Adults with Suspected Developmental Coordination Disorder (DCD)

    ERIC Educational Resources Information Center

    Tal-Saban, Miri; Zarka, Salman; Grotto, Itamar; Ornoy, Asher; Parush, Shula

    2012-01-01

    We assessed the non-academic and academic functioning of young adults with DCD, and investigated the emotional influences and the role of strategy use within this population. A random sample of 2379 adolescents and young adults aged 19-25 (1081 males [45.4%]; mean age = 20.68, SD = 3.42) was used to develop the instruments. From this sample, three…

  9. The Functional Profile of Young Adults with Suspected Developmental Coordination Disorder (DCD)

    ERIC Educational Resources Information Center

    Tal-Saban, Miri; Zarka, Salman; Grotto, Itamar; Ornoy, Asher; Parush, Shula

    2012-01-01

    We assessed the non-academic and academic functioning of young adults with DCD, and investigated the emotional influences and the role of strategy use within this population. A random sample of 2379 adolescents and young adults aged 19-25 (1081 males [45.4%]; mean age = 20.68, SD = 3.42) was used to develop the instruments. From this sample, three…

  10. Parent PDD Behavior Inventory Profiles of Young Children Classified According to Autism Diagnostic Observation Schedule-Generic and Autism Diagnostic Interview-Revised Criteria

    ERIC Educational Resources Information Center

    Cohen, Ira L.; Gomez, Tina Rovito; Gonzalez, Maripaz G.; Lennon, Elizabeth M.; Karmel, Bernard Z.; Gardner, Judith M.

    2010-01-01

    Quantitative variations in score profiles from the parent version of the PDD Behavior Inventory (PDDBI) were examined in young Autism and PDD-NOS groups defined by ADOS-G and ADI-R criteria, relative to a not spectrum (NS) group of similar age. Both the Autism and the PDD-NOS group profiles markedly differed from the NS group. The most sensitive…

  11. Relationships between Self-Concept and Resilience Profiles in Young People with Disabilities

    ERIC Educational Resources Information Center

    Suriá Martínez, Raquel

    2016-01-01

    Introduction: The present study aims to identify different profiles in self-concept and resilience. In addition, statistically significant differences in self-concept domains among the profiles previously identified are analyzed. Method: The AF5 Self-Concept Questionnaire ("Cuestionario de Autoconcepto AF5") and the Resilience Scale were…

  12. Relationships between Self-Concept and Resilience Profiles in Young People with Disabilities

    ERIC Educational Resources Information Center

    Suriá Martínez, Raquel

    2016-01-01

    Introduction: The present study aims to identify different profiles in self-concept and resilience. In addition, statistically significant differences in self-concept domains among the profiles previously identified are analyzed. Method: The AF5 Self-Concept Questionnaire ("Cuestionario de Autoconcepto AF5") and the Resilience Scale were…

  13. Technical player profiles related to the physical fitness of young female volleyball players predict team performance.

    PubMed

    Dávila-Romero, C; Hernández-Mocholí, M A; García-Hermoso, A

    2015-03-01

    This study is divided into three sequential stages: identification of fitness and game performance profiles (individual player performance), an assessment of the relationship between these profiles, and an assessment of the relationship between individual player profiles and team performance during play (in championship performance). The overall study sample comprised 525 (19 teams) female volleyball players aged 12-16 years and a subsample (N.=43) used to examine study aims one and two was selected from overall sample. Anthropometric, fitness and individual player performance (actual game) data were collected in the subsample. These data were analyzed through clustering methods, ANOVA and independence chi-square test. Then, we investigated whether the proportion of players with the highest individual player performance profile might predict a team's results in the championship. Cluster analysis identified three volleyball fitness profiles (high, medium, and low) and two individual player performance profiles (high and low). The results showed a relationship between both types of profile (fitness and individual player performance). Then, linear regression revealed a moderate relationship between the number of players with a high volleyball fitness profile and a team's results in the championship (R2=0.23). The current study findings may enable coaches and trainers to manage training programs more efficiently in order to obtain tailor-made training, identify volleyball-specific physical fitness training requirements and reach better results during competitions.

  14. Metabolic profiling of fatty liver in young and middle‐aged adults: Cross‐sectional and prospective analyses of the Young Finns Study

    PubMed Central

    Würtz, Peter; Suomela, Emmi; Lehtovirta, Miia; Kangas, Antti J.; Jula, Antti; Mikkilä, Vera; Viikari, Jorma S.A.; Juonala, Markus; Rönnemaa, Tapani; Hutri‐Kähönen, Nina; Kähönen, Mika; Lehtimäki, Terho; Soininen, Pasi; Ala‐Korpela, Mika; Raitakari, Olli T.

    2016-01-01

    Nonalcoholic fatty liver is associated with obesity‐related metabolic disturbances, but little is known about the metabolic perturbations preceding fatty liver disease. We performed comprehensive metabolic profiling to assess how circulating metabolites, such as lipoprotein lipids, fatty acids, amino acids, and glycolysis‐related metabolites, reflect the presence of and future risk for fatty liver in young adults. Sixty‐eight lipids and metabolites were quantified by nuclear magnetic resonance metabolomics in the population‐based Young Finns Study from serum collected in 2001 (n = 1,575), 2007 (n = 1,509), and 2011 (n = 2,002). Fatty liver was diagnosed by ultrasound in 2011 when participants were aged 34‐49 years (19% prevalence). Cross‐sectional associations as well as 4‐year and 10‐year risks for fatty liver were assessed by logistic regression. Metabolites across multiple pathways were strongly associated with the presence of fatty liver (P < 0.0007 for 60 measures in age‐adjusted and sex‐adjusted cross‐sectional analyses). The strongest direct associations were observed for extremely large very‐low‐density lipoprotein triglycerides (odds ratio [OR] = 4.86 per 1 standard deviation, 95% confidence interval 3.48‐6.78), other very‐low‐density lipoprotein measures, and branched‐chain amino acids (e.g., leucine OR = 2.94, 2.51‐3.44). Strong inverse associations were observed for high‐density lipoprotein measures, e.g., high‐density lipoprotein size (OR = 0.36, 0.30‐0.42) and several fatty acids including omega‐6 (OR = 0.37, 0.32‐0.42). The metabolic associations were attenuated but remained significant after adjusting for waist, physical activity, alcohol consumption, and smoking (P < 0.0007). Similar aberrations in the metabolic profile were observed already 10 years before fatty liver diagnosis. Conclusion: Circulating lipids, fatty acids, and amino acids reflect fatty liver independently of routine metabolic risk

  15. Effect of long-term interactive music therapy on behavior profile and musical skills in young adults with severe autism.

    PubMed

    Boso, Marianna; Emanuele, Enzo; Minazzi, Vera; Abbamonte, Marta; Politi, Pierluigi

    2007-09-01

    Data on the potential behavioral effects of music therapy in autism are scarce. The aim of this study was to investigate whether a musical training program based on interactive music therapy sessions could enhance the behavioral profile and the musical skills of young adults affected by severe autism. Young adults (N = 8) with severe (Childhood Autism Rating Scale >30) autism took part in a total of 52 weekly active music therapy sessions lasting 60 minutes. Each session consisted of a wide range of different musical activities including singing, piano playing, and drumming. Clinical rating scales included the Clinical Global Impression (CGI) scale and the Brief Psychiatric Rating Scale (BPRS). Musical skills-including singing a short or long melody, playing the C scale on a keyboard, music absorption, rhythm reproduction, and execution of complex rhythmic patterns-were rated on a 5-point Likert-type scale ranging from "completely/entirely absent" to "completely/entirely present." At the end of the 52-week training period, significant improvements were found on both the CGI and BPRS scales. Similarly, the patients' musical skills significantly ameliorated as compared to baseline ratings. Our pilot data seem to suggest that active music therapy sessions could be of aid in improving autistic symptoms, as well as personal musical skills in young adults with severe autism.

  16. BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries.

    PubMed

    Govindaraj, Vijayakumar; Krishnagiri, Harshini; Chauhan, Manmohan Singh; Rao, A J

    2017-04-03

    In our previous study, we demonstrated that the repair efficiency of DNA double-strand breaks declines with increasing age in rat primordial follicles. In the present study, we extended our studies to buffalo (Bubalus bubalis) wherein we studied the expression of BRCA-1 related DNA repair genes in primordial follicles of young (12 months-22 months) and adult (72-96 months) buffaloes. The relative expression of selected genes, as determined by RT-PCR, revealed a significant (p < 0.05) decrease in mRNA levels of BRCA1, MRE11, RAD51, ATM, and H2AX in adult primordial follicles as compared to the young. Western blot analysis revealed a significant (p < 0.05) decrease in the expression of phosphorylated protein levels of BRCA1 and H2AX in adult buffalo primordial follicles. The protein expression profile of young and adult buffalo primordial follicles revealed differential expression of proteins involved in mitochondrial function, cell survival and cell metabolism. Similar to reports from aging rodent and human primordial follicles, our findings support the fact that impairment of DNA repair may be an universal mechanism involved in oocyte aging.

  17. Barriers and Promising Approaches to Workforce and Youth Development for Young Offenders. Program Profiles.

    ERIC Educational Resources Information Center

    Brown, David; Maxwell, Sarah; DeJesus, Edward; Schiraldi, Vincent

    This publication is part of a toolkit that examines systemic barriers to achieving economic self-sufficiency for court-involved youth. It highlights 15 exemplary programs in the world of criminal justice for young people. The programs are all based on youth development principles and are guided by a comprehensive set of core principles that view…

  18. Profiles and Correlates of Relational Aggression in Young Adults' Romantic Relationships

    ERIC Educational Resources Information Center

    Goldstein, Sara E.; Chesir-Teran, Daniel; McFaul, Adrienne

    2008-01-01

    The present study examines prevalence and correlates of experiencing and perpetrating relational aggression in the context of young adults' romantic relationships. We assess correlates of relational aggression in four domains of risk: (1) Social-cognitive, (2) Relationship, (3) Trait/dispositional, and (4) Mental health. Results indicate that…

  19. Neuropsychological Outcome in Adolescents/Young Adults with Childhood ADHD: Profiles of Persisters, Remitters and Controls

    ERIC Educational Resources Information Center

    Halperin, Jeffrey M.; Trampush, Joey W.; Miller, Carlin J.; Marks, David J.; Newcorn, Jeffrey H.

    2008-01-01

    Background: This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures of executive processes would parallel adolescent clinical status, with ADHD-persisters, but not…

  20. Five Million Children: A Statistical Profile of Our Poorest Young Citizens. Data Sourcebook.

    ERIC Educational Resources Information Center

    Columbia Univ., New York, NY. National Center for Children in Poverty.

    This sourcebook provides researchers and other interested professionals with 50 tables of statistical data supporting the findings of a 1990 report on the needs and problems of poor young children and their families. Information was drawn from primary and secondary analyses of 1987 statistical data in national databases, as well as both published…

  1. Young Children's Internet Use at Home and School: Patterns and Profiles

    ERIC Educational Resources Information Center

    Johnson, Genevieve Marie

    2010-01-01

    Thirty-eight children in first and second grade completed a 10-item rating scale on Internet use at home and school. Results suggested that, in general, more children used the Internet at school than at home but home-based use was more often perceived as enjoyable. Three patterns of Internet use emerged suggesting three types of young users:…

  2. Young Children's Internet Use at Home and School: Patterns and Profiles

    ERIC Educational Resources Information Center

    Johnson, Genevieve Marie

    2010-01-01

    Thirty-eight children in first and second grade completed a 10-item rating scale on Internet use at home and school. Results suggested that, in general, more children used the Internet at school than at home but home-based use was more often perceived as enjoyable. Three patterns of Internet use emerged suggesting three types of young users:…

  3. Social and mental health profiles of young male offenders in detention in Greece.

    PubMed

    Maniadaki, Katerina; Kakouros, Efthymios

    2008-01-01

    Among young offenders, mental health problems have been linked both to more serious delinquent acts and to high recidivism rates, but there has been little study of this in Greece. The aims of this study were to describe demographic and family characteristics of young incarcerated male offenders, to determine the prevalence of mental disorders among them and to compare native Greeks with immigrants on these variables. Ninety-three young males, randomly selected from the three main juvenile detention facilities in Greece, completed the Greek version of the Youth Self Report (YSR); the institutions' social workers completed a questionnaire designed for the study on the youths' demographics and offending. Results revealed over-representation of immigrants, high levels of psychosocial adversity (large family size, low parental educational level, poverty and family offending history) and high prevalence rates not only of externalizing disorders, such as conduct disorder, but also internalizing disorders, including anxiety, depression and somatizing problems. Young males in Greek correctional institutions need support at many levels, and especially for mental health problems. This will have implications for staff training and juvenile justice system reform. Copyright (c) 2008 John Wiley & Sons, Ltd.

  4. Neuropsychological Outcome in Adolescents/Young Adults with Childhood ADHD: Profiles of Persisters, Remitters and Controls

    ERIC Educational Resources Information Center

    Halperin, Jeffrey M.; Trampush, Joey W.; Miller, Carlin J.; Marks, David J.; Newcorn, Jeffrey H.

    2008-01-01

    Background: This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures of executive processes would parallel adolescent clinical status, with ADHD-persisters, but not…

  5. Profiles and Correlates of Relational Aggression in Young Adults' Romantic Relationships

    ERIC Educational Resources Information Center

    Goldstein, Sara E.; Chesir-Teran, Daniel; McFaul, Adrienne

    2008-01-01

    The present study examines prevalence and correlates of experiencing and perpetrating relational aggression in the context of young adults' romantic relationships. We assess correlates of relational aggression in four domains of risk: (1) Social-cognitive, (2) Relationship, (3) Trait/dispositional, and (4) Mental health. Results indicate that…

  6. Mont Terri Underground Rock Laboratory, Switzerland-Research Program And Key Results

    NASA Astrophysics Data System (ADS)

    Nussbaum, C. O.; Bossart, P. J.

    2012-12-01

    Argillaceous formations generally act as aquitards because of their low hydraulic conductivities. This property, together with the large retention capacity of clays for cationic contaminants and the potential for self-sealing, has brought clay formations into focus as potential host rocks for the geological disposal of radioactive waste. Excavated in the Opalinus Clay formation, the Mont Terri underground rock laboratory in the Jura Mountains of NW Switzerland is an important international test site for researching clay formations. Research is carried out in the underground facility, which is located adjacent to the security gallery of the Mont Terri motorway tunnel. Fifteen partners from European countries, USA, Canada and Japan participate in the project. The objectives of the research program are to analyze the hydrogeological, geochemical and rock mechanical properties of the Opalinus Clay, to determine the changes induced by the excavation of galleries and by heating of the rock formation, to test sealing and container emplacement techniques and to evaluate and improve suitable investigation techniques. For the safety of deep geological disposal, it is of key importance to understand the processes occurring in the undisturbed argillaceous environment, as well as the processes in a disturbed system, during the operation of the repository. The objectives are related to: 1. Understanding processes and mechanisms in undisturbed clays and 2. Experiments related to repository-induced perturbations. Experiments of the first group are dedicated to: i) Improvement of drilling and excavation technologies and sampling methods; ii) Estimation of hydrogeological, rock mechanical and geochemical parameters of the undisturbed Opalinus Clay. Upscaling of parameters from laboratory to in situ scale; iii) Geochemistry of porewater and natural gases; evolution of porewater over time scales; iv) Assessment of long-term hydraulic transients associated with erosion and thermal

  7. Schoolwork engagement and burnout among Finnish high school students and young adults: profiles, progressions, and educational outcomes.

    PubMed

    Tuominen-Soini, Heta; Salmela-Aro, Katariina

    2014-03-01

    Applying a person-centered approach, the primary aim of this study was to examine what profiles of schoolwork engagement and burnout (i.e., exhaustion, cynicism, inadequacy) can be identified in high school (N = 979) and among the same participants in young adulthood (ages ranging from 17 to 25). We also examined gender differences, group differences in academic and socioemotional functioning and long-term educational outcomes, and temporal stability in the group memberships. Latent profile analysis identified 4 groups of students in high school. Both engaged (44%) and engaged-exhausted (28%) students were engaged and doing well in school, although engaged-exhausted students were more stressed and preoccupied with possible failures. Cynical (14%) and burned-out (14%) students were less engaged, valued school less, and had lower academic achievement. Cynical students, however, were less stressed, exhausted, and depressed than burned-out students. Six years later, engaged students were more likely than predicted by chance to attend university. In young adulthood, 4 similar groups were identified. Configural frequency analysis indicated that it was typical for engaged students to stay in the engaged group and for engaged-exhausted students to move into a more disengaged group. The results on broadband stability from adolescence to young adulthood showed that 60% of the youth manifested stable engaged and 7% stable disengaged patterns, whereas 16% displayed emergent engagement and 17% emergent disengagement patterns. Overall, the findings demonstrate that adolescence is not a uniform time for either school engagement and well-being or disengagement and distress.

  8. Latent profiles of executive functioning in healthy young adults: evidence of individual differences in hemispheric asymmetry.

    PubMed

    Rau, Holly K; Suchy, Yana; Butner, Jonathan E; Williams, Paula G

    2016-11-01

    Two competing theoretical models of individual differences in executive functioning (EF) were examined: the Prefrontal Convexity Model and the Hemispheric Asymmetry Model. Neurologically healthy individuals (N = 315; mean age 20.8) completed a modified switching task (MST) and the Attention Network Test (ANT) in a single testing session. Data analysis was conducted in two phases. In the first phase (model identification), latent profile analysis was applied to MST variables measuring the abilities to form, switch, and maintain mental sets under conditions designed to tax left or right hemisphere resources. In the second phase (model validation), participant clusters obtained from the first phase were compared on the ANT. The Model Identification phase yielded a 3-profile solution consistent with the Hemispheric Asymmetry Model. Profile 1 (N = 203) was characterized by average EF performances. Profile 2 (N = 43) revealed a set maintenance weakness under non-verbal conditions. Profile 3 (N = 38) demonstrated weaknesses in cognitive flexibility combined with poor executive performances under verbal conditions. The Model Validation phase confirmed group differences. Profile 1 demonstrated average EF performances. Profile 2 demonstrated distractibility and decreased alertness, consistent with a right hemisphere weakness. Profile 3 demonstrated cognitive rigidity in the absence of external cues, consistent with a left hemisphere weakness. Individual differences in EF appear to follow a Hemispheric Asymmetry Model of EF among neurologically healthy adults. Investigating the relationship between hemispherically mediated executive functions and other individual difference factors known to confer health risk or resilience could inform numerous disciplines within the field of psychology.

  9. Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms.

    PubMed

    Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N; Mayes, Susan D; Liao, Duanping; Bixler, Edward O

    2017-02-01

    Based on previous studies reporting on the association of objective sleep duration and physiologic changes (i.e., increased cortisol) in children, we examined the role of objective sleep duration on differentiating behavioral profiles in children with insomnia symptoms. Seven hundred children (ages 5-12, 47.8% male) from the Penn State Child Cohort underwent a nine-hour polysomnography and parent completed Pediatric Behavior Scale. Insomnia symptoms were defined as parent report of difficulty falling and/or staying asleep, sleep disordered breathing as an AHI of ≥1, and objective short sleep duration as a total sleep time < 7.7 h. Children with insomnia symptoms demonstrated more overall behavioral problems than controls. Significant interactions between insomnia symptoms and objective sleep duration on scores of externalizing behaviors, mood variability and school problems were found. Profile analyses showed that children with insomnia symptoms and normal sleep duration were associated with clinically elevated externalizing behaviors, inattention, mood variability, and school problems, while children with insomnia and short sleep duration were associated with an overall elevated profile in which internalizing behaviors were more prominent. Childhood insomnia symptoms are associated with a wide array of behavioral problems, for which objective sleep duration is useful in differentiating behavioral profiles. Children with insomnia symptoms and normal sleep duration had a behavioral profile consistent with limit-setting and rule-breaking behaviors, while children with insomnia symptoms and short sleep duration had a behavioral profile more consistent with internalizing behaviors resembling that of psychophysiological disorders.

  10. Profiles.

    ERIC Educational Resources Information Center

    Macintosh, Henry G.

    An introduction to profiles is presented with examples provided to permit an overall appraisal of the potential of profiles, of the principles upon which they might be based, and of the problems that will have to be overcome if their potential is to be realized in practice. The larger scale examples of profiles discussed are the Scottish Pupil…

  11. Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders.

    PubMed

    Carpenter, Joanne S; Robillard, Rébecca; Hermens, Daniel F; Naismith, Sharon L; Gordon, Christopher; Scott, Elizabeth M; Hickie, Ian B

    2017-11-01

    While disturbances of the sleep-wake cycle are common in people with affective disorders, the characteristics of these disturbances differ greatly between individuals. This heterogeneity is likely to reflect multiple underlying pathophysiologies, with different perturbations in circadian systems contributing to the variation in sleep-wake cycle disturbances. Such disturbances may be particularly relevant in adolescents and young adults with affective disorders as circadian rhythms undergo considerable change during this key developmental period. This study aimed to identify profiles of sleep-wake disturbance in young people with affective disorders and investigate associations with biological circadian rhythms. Fifty young people with affective disorders and 19 control participants (aged 16-31 years) underwent actigraphy monitoring for approximately two weeks to derive sleep-wake cycle parameters, and completed an in-laboratory assessment including evening dim-light saliva collection for melatonin assay and overnight continuous core body temperature measurement. Cluster analysis based on sleep-wake cycle parameters identified three distinct patient groups, characterised by 'delayed sleep-wake', 'disrupted sleep', and 'long sleep' respectively. The 'delayed sleep-wake' group had both delayed melatonin onset and core temperature nadir; whereas the other two cluster groups did not differ from controls on these circadian markers. The three groups did not differ on clinical characteristics. These results provide evidence that only some types of sleep-wake disturbance in young people with affective disorders are associated with fundamental circadian perturbations. Consequently, interventions targeting endogenous circadian rhythms to promote a phase shift may be particularly relevant in youth with affective disorders presenting with delayed sleep-wake cycles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Profile of Non-communicable Disease Risk Factors Among Young People in Palau

    PubMed Central

    Chiang, Chifa; Singeo, Singeru Travis; Yatsuya, Hiroshi; Honjo, Kaori; Mita, Takashi; Ikerdeu, Edolem; Cui, Renzhe; Li, Yuanying; Watson, Berry Moon; Ngirmang, Gregorio; Iso, Hiroyasu; Aoyama, Atsuko

    2015-01-01

    Background Although non-communicable diseases (NCDs) have become the predominant health problems of Palauan society, there have been no comprehensive data on NCD risk factors available to develop effective control strategies. Therefore, the first Palauan national STEPwise approach to risk factor Surveillance (STEPS) was completed in mid-2013 to provide information on its adult population aged 25 to 64 years. This study aims to obtain corresponding data from the younger adults aged 18 to 24 years, who remained to be surveyed. Methods We conducted an epidemiological study, targeting the 18- to 24-year-old age group. A survey station and a mobile team were established to recruit voluntary participants dwelling in Koror. A slightly modified WHO STEPS instrument was used, including a structured questionnaire for behavioral risk factors, physical measurements, and blood tests. Results A total of 356 young people were recruited during the survey. In both sexes, nearly half of the participants were overweight/obese. The prevalence of hypertension was higher in men than in women (17.6% vs 1.7%). Raised blood glucose and impaired fasting glucose were observed in 3.5% and 5.2% of the total participants, respectively. About 36% of the subjects were observed to have raised levels of total cholesterol. More than 70% of the young people were current tobacco users, in terms of all kinds of tobacco products. Conclusions The current survey, for the first time, revealed a high prevalence of NCD risk factors, especially overweight/obesity and tobacco use, among young people in Palau. This indicates that swift measures against NCDs are required even in this young age group. PMID:25787240

  13. Profile of Non-communicable Disease Risk Factors Among Young People in Palau.

    PubMed

    Chiang, Chifa; Singeo, Singeru Travis; Yatsuya, Hiroshi; Honjo, Kaori; Mita, Takashi; Ikerdeu, Edolem; Cui, Renzhe; Li, Yuanying; Watson, Berry Moon; Ngirmang, Gregorio; Iso, Hiroyasu; Aoyama, Atsuko

    2015-01-01

    Although non-communicable diseases (NCDs) have become the predominant health problems of Palauan society, there have been no comprehensive data on NCD risk factors available to develop effective control strategies. Therefore, the first Palauan national STEPwise approach to risk factor Surveillance (STEPS) was completed in mid-2013 to provide information on its adult population aged 25 to 64 years. This study aims to obtain corresponding data from the younger adults aged 18 to 24 years, who remained to be surveyed. We conducted an epidemiological study, targeting the 18- to 24-year-old age group. A survey station and a mobile team were established to recruit voluntary participants dwelling in Koror. A slightly modified WHO STEPS instrument was used, including a structured questionnaire for behavioral risk factors, physical measurements, and blood tests. A total of 356 young people were recruited during the survey. In both sexes, nearly half of the participants were overweight/obese. The prevalence of hypertension was higher in men than in women (17.6% vs 1.7%). Raised blood glucose and impaired fasting glucose were observed in 3.5% and 5.2% of the total participants, respectively. About 36% of the subjects were observed to have raised levels of total cholesterol. More than 70% of the young people were current tobacco users, in terms of all kinds of tobacco products. The current survey, for the first time, revealed a high prevalence of NCD risk factors, especially overweight/obesity and tobacco use, among young people in Palau. This indicates that swift measures against NCDs are required even in this young age group.

  14. Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A meta-analysis.

    PubMed

    Cannarella, Rossella; La Vignera, Sandro; Condorelli, Rosita A; Calogero, Aldo E

    2017-08-10

    Hormonal and metabolic abnormalities have been reported in men with early-onset androgenetic alopecia (AGA). Although this has been ascribed to the existence of a male polycystic ovary syndrome (PCOS)-equivalent, data on this topic are inconsistent and this syndrome has not been already acknowledged. To evaluate if, already before the age of 35 years, any difference occurs in the glycolipid and hormonal profiles and in the body weight in men with AGA compared to age-matched controls, we performed a comprehensive meta-analysis of all the available observational case-control studies of literature, using MEDLINE, Google Schoolar and Scopus databases. Among 10596 papers retrieved, seven studies were finally included, enrolling a total of 1009 participants. Our findings demonstrate that young men with AGA have a slightly but significantly worse glycolipid profile compared to controls and a hormonal pattern resembling those of women with PCOS, already before the age of 35 years. Therefore, early-onset AGA might represent a phenotypic sign of the male PCOS-equivalent. The acknowledgement of this syndrome would be of importance to prevent the long-term consequences on health in the affected men. The glycolipid profile and the body weight should be monitored in men with AGA starting from the second decade of life.

  15. Anisotropy of electrical conductivity of the excavation damaged zone in the Mont Terri Underground Rock Laboratory

    NASA Astrophysics Data System (ADS)

    Nicollin, Florence; Gibert, Dominique; Lesparre, Nolwenn; Nussbaum, Christophe

    2010-04-01

    Electrical resistivity measurements were performed to characterize the anisotropy of electrical resistivity of the excavation damaged zone (EDZ) at the end-face of a gallery in the Opalinus clay of the Mont Terri Underground Rock Laboratory (URL). The data were acquired with a combination of square arrays in 18 zones on the gallery's face and in two series of four boreholes perpendicular to the face. Each data set is independently inverted using simulated annealing to recover the resistivity tensor. Both the stability and the non-uniqueness of the inverse problem are discussed with synthetic examples. The inversion of the data shows that the face is split in two domains separated by a tectonic fracture, with different resistivity values but with a common orientation. The direction of the maximum resistivity is found perpendicular to the bedding plane, and the direction of minimum resistivity is contained in the face's plane. These results show that the geo-electrical structure of the EDZ is controlled by a combination of effects due to tectonics, stratigraphy, and recent fracturing produced by the excavation of the gallery.

  16. Differences in Sexual Practices, Sexual Behavior and HIV Risk Profile between Adolescents and Young Persons in Rural and Urban Nigeria.

    PubMed

    Folayan, Morenike Oluwatoyin; Adebajo, Sylvia; Adeyemi, Adedayo; Ogungbemi, Kayode Micheal

    2015-01-01

    We aimed to determine differences in sexual practices, HIV sexual risk behaviors, and HIV risk profile of adolescents and young persons' in rural and urban Nigeria. We recruited 772 participants 15 to 24 years old from urban and rural townships in Nigeria through a household survey. Information on participants' socio-demographic profile (age sex, residential area, number of meals taken per day), sexual practices (vagina, oral and anal sex; heterosexual and homosexual sex; sex with spouse, casual acquaintances, boy/girlfriend and commercial sex workers), sexual behavior (age of sexual debut, use of condom, multiple sex partners, transactional sex and age of sexual partner), and other HIV risk factors (use of alcohol and psychoactive substances, reason for sexual debut, knowledge of HIV prevention and HIV transmission, report of STI symptoms) were collected through an interviewer administered questionnaire. Differences in sexual behavior and sexual practices of adolescents and HIV risk profile of adolescents and young persons resident in urban and rural areas were determined. More than half (53.5%) of the respondents were sexually active, with more residing in the rural than urban areas (64.9% vs 44.1%; p<0.001) and more resident in the rural area reporting having more than one sexual partner (29.5% vs 20.4%; p = 0.04). Also, 97.3% of sexually active respondents reported having vaginal sex, 8.7% reported oral sex and 1.9% reported anal sex. More male than female respondents in the urban area used condoms during the last vaginal sexual intercourse (69.1% vs 51.9%; p = 0.02), and reported sex with casual partners (7.0% vs 15.3%; p = 0.007). More female than male respondents residing in the rural area engaged in transactional sex (1.0% vs 6.7%; p = 0.005). More females than males in both rural (3.6% vs 10.2%; p = 0.04) and urban (4.7% vs 26.6%; p<0.001) areas self-reported a history of discharge. More females than males in both rural (1.4% vs 17.0%; p = 0.04) and urban

  17. Biography Today: Sports Series. Profiles of People of Interest to Young Readers, Volume 4.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This book is the fourth in a series of biographies on today's sports figures designed for students age 9 years and older. It contains alphabetically arranged sketches of the sports figures. Each entry provides at least one picture of the individual profiled. Bold faced rubrics lead the reader to information on birth, youth, early memories,…

  18. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 4.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the fourth volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  19. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 3.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the third volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  20. Biography Today: Profiles of People of Interest to Young Readers. Sports Series, Volume 8.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This volume provides biographies on sports figures. Each entry offers at least one picture of the individual profiled, and bold-faced rubrics lead to information on birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences, hobbies, and honors and awards. Each entry ends with a list of…

  1. Young Children with Cri-du-Chat: Genetic, Developmental, and Behavioral Profiles.

    ERIC Educational Resources Information Center

    Baird, Samera M.; Campbell, Dennis; Ingram, Rebecca; Gomez, Caroline

    2001-01-01

    This paper describes the developmental and behavioral patterns of 13 prelinguistic children (ages 11 to 47 months) with Cri-du-chat syndrome (CDCS). Parents provided demographic and genetic information, descriptions of their child's typical behavior, and completed a developmental checklist. Developmental, behavioral, and genetic profiles are…

  2. Biography Today: Profiles of People of Interest to Young Readers. Sports Series, Volume 7.

    ERIC Educational Resources Information Center

    Abbey, Cherie D., Ed.

    This volume provides biographies on sports figures. Each entry offers at least one picture of the individual profiled, and bold-faced rubrics lead to information on birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences, hobbies, and honors and awards. Each entry ends with a list of…

  3. Toe clearance and velocity profiles of young and elderly during walking on sloped surfaces

    PubMed Central

    2010-01-01

    Background Most falls in older adults are reported during locomotion and tripping has been identified as a major cause of falls. Challenging environments (e.g., walking on slopes) are potential interventions for maintaining balance and gait skills. The aims of this study were: 1) to investigate whether or not distributions of two important gait variables [minimum toe clearance (MTC) and foot velocity at MTC (VelMTC)] and locomotor control strategies are altered during walking on sloped surfaces, and 2) if altered, are they maintained at two groups (young and elderly female groups). Methods MTC and VelMTC data during walking on a treadmill at sloped surfaces (+3°, 0° and -3°) were analysed for 9 young (Y) and 8 elderly (E) female subjects. Results MTC distributions were found to be positively skewed whereas VelMTC distributions were negatively skewed for both groups on all slopes. Median MTC values increased (Y = 33%, E = 7%) at negative slope but decreased (Y = 25%, E = 15%) while walking on the positive slope surface compared to their MTC values at the flat surface (0°). Analysis of VelMTC distributions also indicated significantly (p < 0.05) lower minimum and 25th percentile (Q1) values in the elderly at all slopes. Conclusion The young displayed a strong positive correlation between MTC median changes and IQR (interquartile range) changes due to walking on both slopes; however, such correlation was weak in the older adults suggesting differences in control strategies being employed to minimize the risk of tripping. PMID:20423523

  4. Deducing Hybrid Performance from Parental Metabolic Profiles of Young Primary Roots of Maize by Using a Multivariate Diallel Approach

    PubMed Central

    Feher, Kristen; Lisec, Jan; Römisch-Margl, Lilla; Selbig, Joachim; Gierl, Alfons; Piepho, Hans-Peter; Nikoloski, Zoran; Willmitzer, Lothar

    2014-01-01

    Heterosis, the greater vigor of hybrids compared to their parents, has been exploited in maize breeding for more than 100 years to produce ever better performing elite hybrids of increased yield. Despite extensive research, the underlying mechanisms shaping the extent of heterosis are not well understood, rendering the process of selecting an optimal set of parental lines tedious. This study is based on a dataset consisting of 112 metabolite levels in young roots of four parental maize inbred lines and their corresponding twelve hybrids, along with the roots' biomass as a heterotic trait. Because the parental biomass is a poor predictor for hybrid biomass, we established a model framework to deduce the biomass of the hybrid from metabolite profiles of its parental lines. In the proposed framework, the hybrid metabolite levels are expressed relative to the parental levels by incorporating the standard concept of additivity/dominance, which we name the Combined Relative Level (CRL). Our modeling strategy includes a feature selection step on the parental levels which are demonstrated to be predictive of CRL across many hybrid metabolites. We demonstrate that these selected parental metabolites are further predictive of hybrid biomass. Our approach directly employs the diallel structure in a multivariate fashion, whereby we attempt to not only predict macroscopic phenotype (biomass), but also molecular phenotype (metabolite profiles). Therefore, our study provides the first steps for further investigations of the genetic determinants to metabolism and, ultimately, growth. Finally, our success on the small-scale experiments implies a valid strategy for large-scale experiments, where parental metabolite profiles may be used together with profiles of selected hybrids as a training set to predict biomass of all possible hybrids. PMID:24409329

  5. Alterations in Activation, Cytotoxic Capacity and Trafficking Profile of Peripheral CD8 T Cells in Young Adult Binge Drinkers

    PubMed Central

    Zaldivar Fujigaki, José Luis; Arroyo Valerio, América Guadalupe; López Alvarenga, Juan Carlos; Gutiérrez Reyes, Esperanza Gabriela; Kershenobich, David; Hernández Ruiz, Joselin

    2015-01-01

    Background Excess of alcohol consumption is a public health problem and has documented effects on the immune system of humans and animals. Animal and in vitro studies suggest that alcohol abuse changes CD8 T cell (CD8) characteristics, however it remains unknown if the CD8 profile of binge drinkers is different in terms of activation, trafficking and cytotoxic capacity. Aim To analyze the peripheral CD8 cytotoxic capacity, activation and trafficking phenotypic profile of Mexican young adults with regard to alcohol consumption pattern. Methods 55 Mexican young adults were stratified as Light (20), Intermediate (18) or Binge drinkers (17) according to their reported alcohol consumption pattern. Blood samples were obtained and hematic biometry and liver enzyme analysis were performed. Peripheral CD8 profile was established by expression of Granzyme B (GB), CD137, CD127, CD69, TLR4, PD1, CCR2, CCR4, CCR5 and CXCR4 by FACS. Data was analyzed by ANOVA, posthoc DMS and Tamhane, and principal component analysis (PCA) with varimax rotation, p<0.05. Results The Binge drinking group showed increased γGT together with increased expression of CD69 and reduced expression of TLR4, PD1, CCR2 and CXCR4 in peripheral CD8 cells. Other parameters were also specific to Binge drinkers. PCA established 3 factors associated with alcohol consumption: “Early Activation” represented by CD69 and TLR4 expression in the CD8 population; “Effector Activation” by CD69 expression in CD8 CD127+CD137+ and CD8 CD25+ CD137+; and Trafficking by CXCR4 expression on total CD8 and CD8 GB+CXCR4+, and CCR2 expression on total CD8. Binge drinking pattern showed low expression of Early Activation and Trafficking factors while Light drinking pattern exhibited high expression of Effector Activation factor. Conclusions Alcohol consumption affects the immune phenotype of CD8 cells since binge drinking pattern was found to be associated with high CD69 and low TLR4, CXCR4 and CCR2 expression, which suggest

  6. The Activity Profile of Young Tennis Athletes Playing on Clay and Hard Courts: Preliminary Data.

    PubMed

    Adriano Pereira, Lucas; Freitas, Victor; Arruda Moura, Felipe; Saldanha Aoki, Marcelo; Loturco, Irineu; Yuzo Nakamura, Fábio

    2016-04-01

    The aim of this study was to compare the kinematic characteristics of tennis matches between red clay and hard courts in young tennis players. Eight young tennis players performed two tennis matches on different court surfaces. The match activities were monitored using GPS units. The distance covered in different velocity ranges and the number of accelerations were analyzed. The paired t test and inference based on magnitudes were used to compare the match physical performance between groups. The total distance (24% of difference), high-intensity running distance (15 - 18 km/h) (30% of difference), the number of high-intensity activities (44% of difference), the body load (1% of difference), and accelerations >1.5 g (1.5-2 g and >2 g 7.8 and 8.1 % of difference, respectively) were significantly greater in clay court than hard court matches (p < 0.05). Matches played on the red clay court required players to cover more total and high-intensity running distances and engage in more high-intensity activities than the matches played on the hard court. Finally, on the clay court the body load and the number of accelerations performed (>1.5 g) were possibly higher than on the hard court.

  7. The Activity Profile of Young Tennis Athletes Playing on Clay and Hard Courts: Preliminary Data

    PubMed Central

    Adriano Pereira, Lucas; Freitas, Victor; Arruda Moura, Felipe; Saldanha Aoki, Marcelo; Loturco, Irineu

    2016-01-01

    Abstract The aim of this study was to compare the kinematic characteristics of tennis matches between red clay and hard courts in young tennis players. Eight young tennis players performed two tennis matches on different court surfaces. The match activities were monitored using GPS units. The distance covered in different velocity ranges and the number of accelerations were analyzed. The paired t test and inference based on magnitudes were used to compare the match physical performance between groups. The total distance (24% of difference), high-intensity running distance (15 - 18 km/h) (30% of difference), the number of high-intensity activities (44% of difference), the body load (1% of difference), and accelerations >1.5 g (1.5-2 g and >2 g 7.8 and 8.1 % of difference, respectively) were significantly greater in clay court than hard court matches (p < 0.05). Matches played on the red clay court required players to cover more total and high-intensity running distances and engage in more high-intensity activities than the matches played on the hard court. Finally, on the clay court the body load and the number of accelerations performed (>1.5 g) were possibly higher than on the hard court. PMID:28149359

  8. Serum adipocytokine profile and metabolic syndrome in young adult female dermatomyositis patients.

    PubMed

    Silva, Marilda Guimarães; Borba, Eduardo Ferreira; Mello, Suzana Beatriz Veríssimo de; Shinjo, Samuel Katsuyuki

    2016-12-01

    To analyse the frequency of metabolic syndrome in young adult female dermatomyositis patients and its possible association with clinical and laboratory dermatomyositis-related features and serum adipocytokines. This cross-sectional study included 35 dermatomyositis patients and 48 healthy controls. Metabolic syndrome was defined according to the 2009 Joint Interim Statement. Patient age was comparable in the dermatomyositis and control groups, and the median disease duration was 1.0 year. An increased prevalence of metabolic syndrome was detected in the dermatomyositis group (34.3% vs. 6.3%; p=0.001). In addition, increased serum adiponectin and resistin levels were noted in contrast to lower leptin levels. In dermatomyositis patients, adipocytokine levels were correlated with the levels of total cholesterol, low-density cholesterol, triglycerides and muscle enzymes. A comparison of dermatomyositis patients with (n=12) and without (n=23) syndrome metabolic revealed that adipocytokine levels were also correlated with age, and that dermatomyositis patients with metabolic syndrome tended to have more disease activity despite similar adipocytokine levels. Metabolic syndrome is highly prevalent in young adult female dermatomyositis patients and is related to age and disease activity. Moreover, increased serum adiponectin and resistin levels were detected in dermatomyositis patients, but lower serum leptin levels were observed.

  9. Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.

    PubMed

    Hermens, D F; Lagopoulos, J; Naismith, S L; Tobias-Webb, J; Hickie, I B

    2012-05-08

    Currently, there are no validated neurobiological methods for distinguishing different pathophysiological pathways in young patients presenting in the early phases of major psychiatric disorders. Hence, treatments are delivered simply on the basis of their possible effects on nonspecific symptom constructs such as depression, cognitive change or psychotic symptoms. In this study, the ratios (relative to creatine) of key metabolites (N-acetyl aspartate, myoinositol, glutamate and glutathione) were measured with proton magnetic resonance spectroscopy ((1)H-MRS) within the anterior cingulate cortex of 88 young persons presenting with major mood or psychotic symptoms. We derived empirically (using a cluster analytical technique) three subgroups of subjects on the basis of their patterns of in vivo brain biochemistry. The three subgroups were distinguished (from each other) by all the four metabolites, in particular, glutathione and glutamate. By contrast, the groups could not be distinguished by differences in terms of other demographic, functional or clinical measures. We propose that this (1)H-MRS-based subclassification system could be used as the basis for much more specific tests of novel intervention strategies (notably, antioxidant and glutamatergic therapies) early in the course of major psychiatric disorders.

  10. Periodontal profile and presence of periodontal pathogens in young African-Americans from Salvador, Ba, Brazil

    PubMed Central

    Victor, Ligia Valéria; Cortelli, Sheila Cavalca; Aquino, Davi Romeiro; de Carvalho Filho, Jonas; Cortelli, José Roberto

    2008-01-01

    This cross-sectional study evaluated the periodontal status and the presence of periodontopathogens in 132 young, black ethnic subjects who live in Salvador/Bahia-Brazil and have never smoked. Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Plaque Index (PI) and Gingival Index (GI) were measured and analyzed by ANOVA and Wilcoxon tests (p<0.05) according to gender and age. The presence of A.actinomycetemcomitans, P.gingivalis, E.corrodens and F.nucleatum was determined by PCR and was analyzed by ANOVA, Wilcoxon, Student-t tests (p<0.05). Mean values of PPD and CAL were 2.18 and 1.0mm, respectively. Clinical parameters did not show differences between subjects of varying gender and age. The microbial prevalence was observed to be 95.45% for E.corrodens followed by F.nucleatum with 68.18%, A.actinomycetemcomitans with 45.45% and P gingivalis with 40.9%. An association between the presence of pathogens and gender and age was not observed (p<0.05). PPD, CAL and PI were not associated with P.gingivalis; however, GI appeared in higher frequencies among subjects without P.gingivalis. In this young, black ethnic, Brazilian population, a high percentage (96.96%) of subjects harbored at least one selected periodontal pathogen, but most subjects showed a healthy periodontal status. Further investigations are required to evaluate the actual influence of the presence of these bacterial species. PMID:24031206

  11. Serum adipocytokine profile and metabolic syndrome in young adult female dermatomyositis patients

    PubMed Central

    Silva, Marilda Guimarães; Borba, Eduardo Ferreira; de Mello, Suzana Beatriz Veríssimo; Shinjo, Samuel Katsuyuki

    2016-01-01

    OBJECTIVES: To analyse the frequency of metabolic syndrome in young adult female dermatomyositis patients and its possible association with clinical and laboratory dermatomyositis-related features and serum adipocytokines. METHOD: This cross-sectional study included 35 dermatomyositis patients and 48 healthy controls. Metabolic syndrome was defined according to the 2009 Joint Interim Statement. RESULTS: Patient age was comparable in the dermatomyositis and control groups, and the median disease duration was 1.0 year. An increased prevalence of metabolic syndrome was detected in the dermatomyositis group (34.3% vs. 6.3%; p=0.001). In addition, increased serum adiponectin and resistin levels were noted in contrast to lower leptin levels. In dermatomyositis patients, adipocytokine levels were correlated with the levels of total cholesterol, low-density cholesterol, triglycerides and muscle enzymes. A comparison of dermatomyositis patients with (n=12) and without (n=23) syndrome metabolic revealed that adipocytokine levels were also correlated with age, and that dermatomyositis patients with metabolic syndrome tended to have more disease activity despite similar adipocytokine levels. CONCLUSIONS: Metabolic syndrome is highly prevalent in young adult female dermatomyositis patients and is related to age and disease activity. Moreover, increased serum adiponectin and resistin levels were detected in dermatomyositis patients, but lower serum leptin levels were observed. PMID:28076515

  12. Abetalipoproteinemia-like lipid profile and acanthocytosis in a young woman with anorexia nervosa.

    PubMed

    Takeshita, Jun; Arai, Yasumichi; Hirose, Nobuyoshi; Tsukamoto, Hideko; Shirahase, Jyoichiro

    2002-11-01

    We report the case of a 17-year-old woman with anorexia nervosa (AN) who developed an abetalipoproteinemia-like lipid profile and acanthocytosis. These abnormalities resolved slowly as her nutritional status improved. We considered 3 possible causes of an abetalipoproteinemia-like lipid profile in AN: (1) depletion of hepatic substrate for apolipoprotein B synthesis, (2) lack of exogenous fatty acids with exhaustion of endogenous stores of triglycerides in adipose tissue, and (3) preservation of the lipoprotein lipase (LPL) mass. This unusual case provides important clues that enhance our understanding of lipid metabolism under exogenous and endogenous fat deprivation and highlights the pivotal role of LPL as a gatekeeper of the energy source.

  13. Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults

    PubMed Central

    Raue, Ulrika; Trappe, Todd A.; Estrem, Shawn T.; Qian, Hui-Rong; Helvering, Leah M.; Smith, Rosamund C.

    2012-01-01

    This investigation examined the effects of acute resistance exercise (RE), progressive resistance training (PRT), and age on the human skeletal muscle Transcriptome. Two cohorts of young and old adults [study A: 24 yr, 84 yr (n = 28); study B: 25 yr, 78 yr (n = 36)] were studied. Vastus lateralis biopsies were obtained pre- and 4 h post-RE in conjunction with the 1st and 36th (last) training session as part of a 12-wk PRT program in study A, whereas biopsies were obtained in the basal untrained state in study B. Additionally, the muscle fiber type specific (MHC I and MHC IIa) Transcriptome response to RE was examined in a subset of young and old women from study A. Transcriptome profiling was performed using HG U133 Plus 2.0 Arrays. The main findings were 1) there were 661 genes affected by RE during the 1st and 36th training bout that correlated with gains in muscle size and strength with PRT (termed the Transcriptome signature of resistance exercise adaptations); 2) the RE gene response was most pronounced in fast-twitch (MHC IIa) muscle fibers and provided additional insight into the skeletal muscle biology affected by RE; 3) skeletal muscle of young adults is more responsive to RE at the gene level compared with old adults and age also affected basal level skeletal muscle gene expression. These skeletal muscle Transcriptome findings provide further insight into the molecular basis of sarcopenia and the impact of resistance exercise at the mixed muscle and fiber type specific level. PMID:22302958

  14. Sleep-wake profiles predict longitudinal changes in manic symptoms and memory in young people with mood disorders.

    PubMed

    Robillard, Rébecca; Hermens, Daniel F; Lee, Rico S C; Jones, Andrew; Carpenter, Joanne S; White, Django; Naismith, Sharon L; Southan, James; Whitwell, Bradley; Scott, Elizabeth M; Hickie, Ian B

    2016-10-01

    Mood disorders are characterized by disabling symptoms and cognitive difficulties which may vary in intensity throughout the course of the illness. Sleep-wake cycles and circadian rhythms influence emotional regulation and cognitive functions. However, the relationships between the sleep-wake disturbances experienced commonly by people with mood disorders and the longitudinal changes in their clinical and cognitive profile are not well characterized. This study investigated associations between initial sleep-wake patterns and longitudinal changes in mood symptoms and cognitive functions in 50 young people (aged 13-33 years) with depression or bipolar disorder. Data were based on actigraphy monitoring conducted over approximately 2 weeks and clinical and neuropsychological assessment. As part of a longitudinal cohort study, these assessments were repeated after a mean follow-up interval of 18.9 months. No significant differences in longitudinal clinical changes were found between the participants with depression and those with bipolar disorder. Lower sleep efficiency was predictive of longitudinal worsening in manic symptoms (P = 0.007). Shorter total sleep time (P = 0.043) and poorer circadian rhythmicity (P = 0.045) were predictive of worsening in verbal memory. These findings suggest that some sleep-wake and circadian disturbances in young people with mood disorders may be associated with less favourable longitudinal outcomes, notably for subsequent manic symptoms and memory difficulties. © 2016 European Sleep Research Society.

  15. Expressive Language Profiles of Verbally Expressive Adolescents and Young Adults with Down Syndrome or Fragile X Syndrome

    PubMed Central

    Finestack, Lizbeth H.; Abbeduto, Leonard

    2010-01-01

    Purpose: This study examined the expressive language abilities of a subset of highly verbally expressive adolescents and young adults with Down syndrome (DS) and those with fragile X syndrome (FXS) for evidence of syndrome-related differences. FXS gender differences were also examined in an exploratory fashion. Method: We evaluated 24 adolescents and young adults with DS, 17 of those with FXS, and 21 children with typical development (TD), with the groups matched on nonverbal mental age. Language ability was examined using the Oral and Written Language Scales (OWLS; Carrow-Woolfolk, 1995) and Developmental Sentence Scoring (DSS; Lee, 1974) scores derived from an oral narrative language sample. Results: Study analyses revealed the following group differences: the FXS group outperformed the DS and TD groups on the OWLS measure; the TD group outperformed both other groups on some of the DSS measures; the FXS group outperformed the DS group on the DSS Sentence Point measure; and females with FXS outperformed males with FXS on several measures. Conclusions: The study results contribute to the ongoing construction of the language phenotypes of individuals with DS and individuals with FXS and support the conclusion that there are quantitative rather than qualitative differences in their expressive language profiles. PMID:20643789

  16. Prediction of ischemic stroke in young Indians: is thrombophilia profiling a way out?

    PubMed

    Chatterjee, Tathagata; Gupta, Neha; Choudhry, Ved Prakash; Behari, Madhuri; Saxena, Renu; Ashraf, Mohammad Z

    2013-06-01

    Stroke in the young is attributed to the prevalence of thrombophilia, however, reports explaining the cause mechanisms from Indian populations are largely not known. The information about the association of inherited thrombophilia and occurrence of stroke is still missing. Therefore, we describe here 52 cases of young ischemic stroke of which 22 cases were of recurrent stroke and 30 cases of first episode stroke along with an equal number of healthy controls. Imaging techniques (CT/MRI/Doppler studies) were used to identify the type and location of infarcts among various regions of the brain. All the patients and controls were screened for hypercoagulable state by employing Pro C global test. Those tested positive for the latter were evaluated for conventional thrombophilic factors, activity levels of protein C and protein S, antithrombin III levels, plasma homocysteine levels and presence of activated protein C resistance, lupus anticoagulant, methylenetetrahydrofolate reductase (MTHFR C677T) and prothrombin G20210A polymorphisms. Out of 52 cases there were 22 cases of recurrent stroke and 30 cases of first ischemic stroke. Infarcts were single in 39 out of 52 cases and multiple in 13 cases. Among the different regions of brain internal capsule infarcts were seen in 13 of 52 (25%) cases, and cerebellum, basal ganglion and midbrain infarcts were seen in five cases (9.6%) each and remaining infarcts were in other anatomical regions of the brain. Left middle cerebral artery territory was involved in 17 of 52 (32.7%) cases. The prevalence of individual thrombophilia among cases ranged from 28.8% (15/52) for protein S and 11.5% (6/52) for protein C deficiencies respectively. All cases of protein C were protein S deficient. Five cases of protein C deficiency patients were of 25 years and younger as compared with one case in the at least 25 years age group. Plasma homocysteine levels were elevated in three cases (5.7%) as compared with normal levels in controls

  17. The speeding attitude scale and the role of sensation seeking in profiling young drivers at risk.

    PubMed

    Whissell, Robert W; Bigelow, Brian J

    2003-08-01

    Seven driving attitude scales representing driving behaviors and beliefs about driving were created and initially validated using 257 undergraduate students (168 females, 89 males) in Study 1. However, the Speeding Attitude Scale (SAS) accounted for most of the strength of the intercorrelations among these scales and discriminant classification analyses showed that SAS dominated the other scales as a sufficient explanation for having speeding tickets. Study 2, using 180 students (75 males, 105 females), replicated findings regarding the significant but low correlation between SAS and speeding tickets, and was significantly correlated with Zuckerman's Sensation Seeking Scale (SSS). Replication also showed that males had higher SAS scores and more speeding tickets. Accidents were typically a function of sex, increasing age, and variables related to recent accident history. Objective sources of speeding attitude confirmation may enhance the future validity of the SAS. Potential interventions for being a safe passenger and attitudinal control in the training of young drivers were discussed.

  18. Immobilization of Candida antarctica A and Thermomyces lanuginosus lipases on cotton terry cloth fibrils using polyethyleneimine.

    PubMed

    Ondul, Eda; Dizge, Nadir; Albayrak, Nedim

    2012-06-15

    In this study, cotton terry cloth fibrils were coated with 0.2% polyethyleneimine (PEI). Lipases from Candida antarctica A (CALA) and Thermomyces lanuginosus (TL) were immobilized on this support through adsorption followed by cross-linking with 0.2% glutaraldehyde. PEI-enzyme aggregates formation and growth of aggregates on cotton cloth fibrils lead to multilayer immobilization of the lipases. PEI and lipase was mixed to form PEI-enzyme complex/aggregate. The highest amount of enzyme precipitate was obtained at the PEI to enzyme ratio of 1/20-1/40 for both lipases. The effect of pH was also investigated for aggregates formation. The results showed that when pH values were below 8, aggregation and precipitation were not occurred for C. antarctica A lipase. However, pH did not affect PEI-enzyme aggregate formation for T. lanuginosus lipase. Immobilized enzyme amount was approximately 180 mg/g support and 200 mg/g support for T. lanuginosus and C. antarctica A lipases, respectively. Effect of the reaction temperature on the relative activity of the free and immobilized lipases at various temperature (30-80 °C) was studied. It was found that immobilization had no effect on the optimum temperature and it was 60 °C for both free and immobilized enzymes. The effect of operational and storage stability on activity of free and immobilized lipases were also investigated. Immobilized lipases exhibited that they could be stored at room temperature with a little activity lost during 28 days. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Conditions for creativity: lessons for lesbians in the lives of Romaine Brooks and Terry Wolverton.

    PubMed

    Walker, Diane

    2010-01-01

    This article considers the lives of Terry Wolverton, former lesbian separatist artist at The Women's Building, Los Angeles and now a mythical writer and visionary, and lesbian painter, Romaine Brooks. Whereas superficially their lives appear to have little in common other than that they were both lesbian artists, similarities can be found in stories linking them in ways previously un-examined before. Both came from abusive family backgrounds, Wolverton surviving sexual abuse and alcoholism, while Brooks' life was marred by a frightening mother and a father who deserted her. Using autobiography and biographical sources, Walker analyzes the creative conditions under which lesbian art may thrive. For a time, gay and lesbian art flourished in the United States. Brooks' portraits of "butch" lesbians became synonymous with popular images of twentieth-century lesbians. Wolverton's work with other lesbian artists in The Lesbian Art Project of 1977-1980 documents their engagement with art. The conditions required for creativity of whatever kind involves journeys and Walker uses the concept of "journeying" as a metaphor to describe the internal and external processes that of necessity accompany the creative act. The content of the article examines what can be learned from the lives of Brooks and Wolverton. Historically the "artist story" (Kunstlerroman) has focused on male and female heterosexual artists. The study of more recent autobiographical accounts permits an examination of the development of artists with cultural differences, and makes it possible to ask what conditions need be in place for lesbian artists to create art to "unfetter the self" when the self in question is different. Walker concludes that the early experiences of Wolverton and Brooks had a profound effect on their adult lives, as both made circuitous creative journeys in attempts to overcome the trauma of childhood years. Whereas one succeeded, the other failed due to the different cultural conditions

  20. Profiles.

    ERIC Educational Resources Information Center

    School Arts, 1979

    1979-01-01

    Profiles seven Black, Native American, and Chicano artists and art teachers: Hale A. Woodruff, Allan Houser, Luis Jimenez, Betrand D. Phillips, James E. Pate, I, and Fernando Navarro. This article is part of a theme issue on multicultural art. (SJL)

  1. Profiles.

    ERIC Educational Resources Information Center

    School Arts, 1979

    1979-01-01

    Profiles seven Black, Native American, and Chicano artists and art teachers: Hale A. Woodruff, Allan Houser, Luis Jimenez, Betrand D. Phillips, James E. Pate, I, and Fernando Navarro. This article is part of a theme issue on multicultural art. (SJL)

  2. Muscle Sympathetic Nerve Activity Is Associated With Elements of the Plasma Lipidomic Profile in Young Asian Adults.

    PubMed

    Eikelis, Nina; Lambert, Elisabeth A; Phillips, Sarah; Sari, Carolina Ika; Mundra, Piyushkumar A; Weir, Jacquelyn M; Huynh, Kevin; Grima, Mariee T; Straznicky, Nora E; Dixon, John B; Schlaich, Markus P; Meikle, Peter J; Lambert, Gavin W

    2017-06-01

    Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 ± 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneurography. The association of MSNA and obesity with lipid species was examined using linear regression analysis. The plasma concentrations of total dihydroceramide, ceramide, GM3 ganglioside, lysoalkylphosphatidylcholine, alkenylphosphatidylethanolamine, and lysophosphatidylinositol were elevated in the Asian subjects relative to the white subjects. After adjustment for confounders, diacylglycerols and triacylglycerols, cholesterol esters, phosphatidylinositols, phosphatidylethanolamines, and phosphatidylglycerols bore significant associations with MSNA but only in the Asian subjects. These associations remained significant after further adjustment for the participants' degree of insulin resistance and appeared not to be related to differences in diet macronutrient content between groups. The lipidomic profile differs between Asian and white subjects. There exists a strong relationship between certain lipid species and MSNA. The association is stronger in Asian subjects, despite their lower BMI. This study demonstrates an association between circulating lipids and central sympathetic outflow. Whether the stronger association between the lipid profile and sympathetic activation underpins the apparent greater risk posed by increased adiposity in Asian individuals merits further attention.

  3. Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls.

    PubMed

    Halperin, Jeffrey M; Trampush, Joey W; Miller, Carlin J; Marks, David J; Newcorn, Jeffrey H

    2008-09-01

    This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures of executive processes would parallel adolescent clinical status, with ADHD-persisters, but not remitters, differing significantly from controls. In contrast, persisters and remitters were hypothesized to perform similarly, and different from controls, on tasks requiring less effortful processing. Ninety-eight participants diagnosed with ADHD in childhood were reevaluated approximately 10 years later. Eighty-five never-ADHD controls similar in age, IQ, and sex distribution served as a comparison group. Participants were administered a psychiatric interview and neuropsychological test battery. Those with childhood ADHD demonstrated broad neuropsychological deficits relative to controls. When the group with childhood ADHD was subdivided based on adolescent ADHD status, compared to controls, both persisters and remitters showed deficient perceptual sensitivity and response variability, and increased ankle movements recorded by a solid-state actigraph. Only persisters differed from controls on several measures of more effortful executive processes. Findings provide preliminary support to the hypothesis that ADHD is associated with early-appearing and enduring subcortical dysfunction, while recovery over the course of development is associated with improvements in executive control functions.

  4. Development of anthropometric and physical performance profiles of young elite male soccer players: a longitudinal study.

    PubMed

    Mirkov, Dragan M; Kukolj, Milos; Ugarkovic, Dusan; Koprivica, Vladimir J; Jaric, Slobodan

    2010-10-01

    The purpose of the present longitudinal study was to explore distinctive anthropometric and physical performance characteristics of young soccer players between the age of 11 and 14 and to reveal the performance at the age of 11, which contributes to the later success. Male players of the best national male squads of the 'cadet league' (14 years of age; n = 26) were annually tested starting from the age of 11 for body size and composition, flexibility, power, coordination, and agility. Randomly selected untrained but physically active age-matched boys (n = 63) were also tested over 4 consecutive years. The results revealed no difference between 2 groups regarding the body size and composition (p > 0.05). The differences in flexibility emerged only at the later age, whereas the differences regarding the explosive power (as assessed by various jumps) were moderate and partly inconsistent. The most prominent advantage of the soccer players over the control subjects during the entire tested age period appeared to be movement agility and coordination (p < 0.01). Therefore, the explosive muscle power and, in particular, the agility and coordination characterize elite soccer players of 11-14 years of age but not the body size and body composition. In addition, the agility and coordination could be among the crucial factors of future success in 11-year-old players and, therefore, should be used for early selection.

  5. Cardiometabolic profiles of adolescents and young adults exposed to the World Trade Center Disaster.

    PubMed

    Trasande, Leonardo; Koshy, Tony T; Gilbert, Joseph; Burdine, Lauren K; Marmor, Michael; Han, Xiaoxia; Shao, Yongzhao; Chemtob, Claude; Attina, Teresa M; Urbina, Elaine M

    2017-09-30

    Few studies have examined the possible cardiometabolic consequences of World Trade Center-related exposures on children who lived and/or attended school near the disaster site. Our objective was to compare cardiometabolic profiles of participants in the World Trade Center Health Registry (WTCHR) with a matched comparison group. We evaluated WTCHR enrollees who resided in New York City and were born between September 11, 1993 and September 10, 2001, and a matched comparison group. We assessed exposure to dust cloud, home dust, as well as traumatic exposure, and associations with blood pressure, arterial wall stiffness, body mass index (BMI), total cholesterol, triglycerides, HDL, and LDL. A total of 402 participants completed the study, 222 in the comparison group and 180 in the WTCHR group. In multivariable regression analysis, after adjusting for relevant confounders we detected a weak association between participation in the WTCHR group and lower BMI (-1.12kg/m(2), 95% CI -2.11, -0.12; p = 0.03), which became non-significant after adjusting for multiple comparisons. With respect to traumatic and psychosocial exposures, the only association that persisted in our multivariable model, below our predefined level of significance, was between post-traumatic stress disorder and higher BMI (2.06kg/m2, 95% CI 0.37, 3.74; p = 0.02). Our findings do not support an association between self-reported exposures to the WTC disaster and adverse cardiometabolic profile. However, further longitudinal studies may better inform the full extent of WTC-related conditions associated with exposure to the disaster. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Cardiac Autonomic Nervous System Activation and Metabolic Profile in Young Children: The ABCD Study

    PubMed Central

    Vrijkotte, Tanja G. M.; van den Born, Bert-Jan H.; Hoekstra, Christine M. C. A.; Gademan, Maaike G. J.; van Eijsden, Manon; de Rooij, Susanne R.; Twickler, Marcel T. B.

    2015-01-01

    Background In adults, increased sympathetic and decreased parasympathetic nervous system activity are associated with a less favorable metabolic profile. Whether this is already determined at early age is unknown. Therefore, we aimed to assess the association between autonomic nervous system activation and metabolic profile and its components in children at age of 5–6 years. Methods Cross-sectional data from an apparently healthy population (within the ABCD study) were collected at age 5–6 years in 1540 children. Heart rate (HR), respiratory sinus arrhythmia (RSA; parasympathetic activity) and pre-ejection period (PEP; sympathetic activity) were assessed during rest. Metabolic components were waist-height ratio (WHtR), systolic blood pressure (SBP), fasting triglycerides, glucose and HDL-cholesterol. Individual components, as well as a cumulative metabolic score, were analyzed. Results In analysis adjusted for child’s physical activity, sleep, anxiety score and other potential confounders, increased HR and decreased RSA were associated with higher WHtR (P< 0.01), higher SBP (p<0.001) and a higher cumulative metabolic score (HR: p < 0.001; RSA: p < 0.01). Lower PEP was only associated with higher SBP (p <0.05). Of all children, 5.6% had 3 or more (out of 5) adverse metabolic components; only higher HR was associated with this risk (per 10 bpm increase: OR = 1.56; p < 0.001). Conclusions This study shows that decreased parasympathetic activity is associated with central adiposity and higher SBP, indicative of increased metabolic risk, already at age 5–6 years. PMID:26394362

  7. Structural and stratigraphic compartmentalization of the Terry Sandstone and effects on reservoir fluid distributions: Latham Bar Trend, Denver Basin: Colorado

    SciTech Connect

    Al-Raisi, M.H.; Slatt, R.M.; Decker, M.K.

    1996-01-01

    The Latham Bar Trend, located in the Denver Basin of Colorado, is an elongate sandstone which extends in a northwest direction for more than 6 mi and is up to 1-2 mi wide. It is now under infill drilling on 40-acre spacing, with more than 65 wells producing from the Upper Cretaceous Terry Sandstone. Detailed analysis of four cores and 210 wells suggests that the Terry Sandstone within the Lantham Bar Trend was deposited in an open marine environment. Reservoir quality, particularly permeability, is primarily facies controlled, and secondarily controlled by diagenetic products. Estimated ultimate recovery (EUR) values in wells are related to thickness of this facies. Structural analysis indicates the Trend is dissected by a series of northeast-trending, northwest-dipping faults with vertical displacements of 30-100 ft. (9-30 m). The faults are interpreted to be sealing, separating the Terry Sandstone into isolated fault blocks, on the basis of the following criteria: (1) normalized GOR values exhibit a non-systematic areal distribution across the trend, but show systematic up-structure increases in GOR within individual fault blocks; (2) initial API gravity values from different wells also are non-systematically distributed areally across the Trend, but show similar groupings within fault blocks; (3) EUR values within each fault block exhibit a positive correlation with thickness of cross-bedded sandstone facies; (4) individual wells with specific normalized GOR values occur at lower structural elevations than wells in adjacent fault blocks with lower GORs, giving rise to structural reversal of fluid distributions. Recognition of the facies control on reservoir quality, reservoir facies thickness, sealing capacity of normal faults, and resultant compartmentalization can help explain complex stratigraphic and areas distribution patterns of gas and oil in these and other strata in the Denver Basin and to maximize reservoir producibility and exploration success.

  8. Semen profiles of young men involved as bicycle taxi cyclists in Mangochi District, Malawi: A case-control study.

    PubMed

    Kipandula, W; Lampiao, F

    2015-12-01

    The purpose of this study was to evaluate the semen profiles of bicycle taxi cyclists and healthy controls in Mangochi district, Malawi. Semen samples were collected from young bicycle taxi cyclists after two to three days of sexual abstinence. A control group, comprising young men who were not bicycle taxi operators also submitted semen samples. Samples were left to liquefy for 30 minutes before measurements were conducted of volume, concentration, total motility, and progressive motility. This was followed by preparation of morphology slides. Light microscopy was used for sperm analysis. Semen parameters such as volume (1.66 ± 0.18 mL vs. 3.64 ± 0.17 mL; p = 0.0001), concentration (28.31 ± 4.33 x 106/mL vs. 54.95 ± 5.93 × 106/mL; p = 0.02) , total motility (56.98% ± 8.22% vs. 56.98% ± 8.22%; p = 0.03), progressive motility (22.57% ± 3.35% vs. 59.69% ± 4.82%; p = 0.004), and morphology (6.98% ± 3.23% vs. 19.73% ± 2.32%; p = 0.006) were significantly reduced in the bicycle taxi cyclists compared to the healthy controls. In this case-control study, bicycle taxi operators had lower semen volume, concentration, total motility, and progressive motility, as well as a higher concentration of abnormally shaped spermatocytes, compared to healthy controls.

  9. Fatty acid profile and meat quality of young bulls fed ground soybean or ground cottonseed and vitamin E.

    PubMed

    Machado Neto, O R; Chizzotti, M L; Ramos, E M; Oliveira, D M; Lanna, D P D; Ribeiro, J S; Lopes, L S; Descalzo, A M; Amorim, T R; Ladeira, M M

    2015-02-01

    The objective of this study was to evaluate the fatty acid profile and qualitative characteristics of meat from feedlot young bulls fed ground soybean or ground cottonseed, with or without supplementation of vitamin E. A total of 40 Red Norte young bulls, with an initial average age of 20 months, and an initial average BW of 339±15 kg, were allotted in a completely randomized design using a 2×2 factorial arrangement, with two oilseeds, and daily supplementation or not of 2500 IU of vitamin E. The experimental period was for 84 days, which was preceded by an adaptation period of 28 days. The treatments were ground soybean (SB), ground soybean plus vitamin E (SBE), ground cottonseed (CS) and ground cottonseed plus vitamin E (CSE). The percentage of cottonseed and soybean in the diets (dry matter basis) was 24% and 20%, respectively. Diets were isonitrogenous (13% CP) and presented similar amount of ether extract (6.5%). The animals were slaughtered at average live weight of 464±15 kg, and samples were taken from the longissimus dorsi muscle for the measurement of fatty acid concentration and the evaluation of lipid oxidation and color of the beef. Before fatty acid extraction, muscle tissue and subcutaneous fat of the longissimus dorsi were separated to analyze fatty acid profile in both tissues. Supplementation of vitamin E did not affect fatty acid concentration, lipid oxidation and color (P>0.05). Subcutaneous fat from animals fed CS diet had greater C12:0, C16:0 and C18:0 contents (P<0.03). In addition, CS diets reduced the C18:1 and C18:2 cis-9, trans-11 contents in subcutaneous fat (P<0.05). The muscle from animals fed CS tended to higher C16:0 and C18:0 contents (P<0.11), and decreased C18:1, C18:2 cis-9, trans-11 and C18:3 contents (P<0.05) compared with SB. The Δ9-desaturase index was greater in muscle from animals fed SB (P<0.01). At 42 days of age, meat from cattle fed SB had a greater lipid oxidation rate (P<0.05). Meat from animals fed SB diets had

  10. Time-series expression profile analysis of fracture healing in young and old mice.

    PubMed

    Yuan, Chun; Cai, Jinfang

    2017-10-01

    Bone fracture healing is a complex process, which is associated with several factors, including age and osteoporosis. Certain genes and biological processes that may contribute to fracture healing, have been identified following developments in systems biology and molecular biology technologies, which may benefit the treatment of bone fractures. The present study identified key genes, which may be important in fracture healing through bioinformatics analysis of gene microarray datasets from the Gene Expression Omnibus. Gene clusters, which were consistently up/downregulated through time following a fracture in young (6‑week‑old) mice and old (8‑month‑old retired breeders) mice were obtained via soft clustering of differentially expressed genes (DEGs) between samples at 1 and 3 days, 1 and 5 days, and 3 and 5 days post‑fracture in the two age groups, based on the Mfuzz package of R. Functional enrichment analysis of gene clusters using the Database for Annotation, Visualization and Integrated Discovery indicated that biological processes and pathways, including those associated with bone development, skeletal system development, amino sugar and nucleotide sugar metabolism, were significantly enriched in these up/downregulated genes. Of note, a total of 207 overlapped consistently upregulated genes were obtained between the two age groups, whereas no overlap was identified between the two lists of consistently downregulated genes. The overlapped genes were found to be associated with the biological processes of blood vessel development, vasculature development and skeletal system development, compared with all genes in the clusters. In addition, certain genes, including epidermal growth factor‑like domain multiple 6 (EGFL6), kazal‑type serine peptidase inhibitor domain 1 (KAZALD1), olfactomedin 2B (OLFM2B), collagen type III α1 (COL3A1), collagen type II α1 (COL2A1), von Willebrand factor A domain‑containing 1 (VWA1), elastin microfibril

  11. Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats.

    PubMed

    Agil, Ahmad; Navarro-Alarcón, Miguel; Ruiz, Rosario; Abuhamadah, Sawsan; El-Mir, Mohamad-Yehia; Vázquez, Gumersindo Fernández

    2011-03-01

    The study objective was to investigate the effects of melatonin on obesity and obesity-associated systolic hypertension and dyslipidemia in young male Zucker diabetic fatty (ZDF) rats, an experimental model of the metabolic syndrome. ZDF rats (n=30) and lean littermates (ZL) (n=30) were used. At 6wk of age, both lean and fatty animals were subdivided into three groups (n=10): naive (N), vehicle-treated (V), and melatonin-treated (M) (10mg/kg/day) for 6wk. Vehicle and melatonin were added to the drinking water. Melatonin reduced mean weight gain (51±2/100g BW) versus N-ZDF group (58±3, P<0.05) without food intake differences. M-ZDF rats showed an apparent reduction in systolic hypertension that proved not to be statistically significant, and a significant improvement in dyslipidemia, with a reduction in hypertriglyceridemia from 580±40 to 420.6±40.9mg/dL (P<0.01). Melatonin raised high-density-lipoprotein (HDL) cholesterol in ZDF (from 81.6±4.9 to 103.1±4.5mg/dL, P<0.01) and ZL rats (from 62.8±4.8 to 73.5±4.8mg/dL, P<0.05) and significantly reduced low-density-lipoprotein (LDL) cholesterol in ZDF rats from 5.20±0.4 to 4.14±0.3 mg/dL (P<0.05) but had no effect on total cholesterol levels. To our knowledge, this is the first evidence of a positive effect of melatonin on overweight and lipid pattern of obese Zucker diabetic rats, supporting the proposition that melatonin administration may ameliorate overweight and lipid metabolism in humans. Because these benefits occurred in youth, before advanced metabolic and vascular complications, melatonin might help to prevent cardiovascular disease associated with obesity and dyslipidemia.

  12. Clinicoepidemiological profile and predictors of severe illness in young infants (< 60 days) reporting to a hospital in North India.

    PubMed

    Deorari, A K; Chellani, H; Carlin, J B; Greenwood, P; Prasad, M S; Satyavani, A; Singh, Jyoti; John, Raji; Taneja, D K; Paul, P; Meenakshi, M; Kapil, A; Paul, V K; Weber, M

    2007-10-01

    To describe the clinical and epidemiological profile of young infants reporting to a hospital and assess previously proposed simple clinical signs for their value in enabling health workers to detect young infants with severe illness warranting hospital admission. Observational study of infants less than 2 months of age presenting consecutively to a large public hospital in South Delhi who were evaluated by a health worker (nurse), on a standardized list of signs and symptoms, and the ability of these were evaluated against the need for hospital admission which was assessed by an independent pediatrician. Of the 1624 young infants triaged, 878 were enrolled into the study. Of these 100 (11%) were below 7 days of age, for whom the common reasons for seeking care were jaundice (52%), not feeding well (6%) and fever (5%). The remaining 778 (89%) were 7-59 days of age with respiratory symptoms as the main presenting complaints (29.1%). The primary clinical diagnoses in infants with serious illness needing admission to hospital in the age group <7 days (n = 66) were hyperbilirubinemia (56%) and sepsis (21%). In those between 7-27 days of age (n = 60), primary diagnoses were sepsis (27%), pneumonia (13%), diarrhea, dysentery or dehydration (10%), while in the age group 28-59 days of age (n = 47) pneumonia (40%), sepsis (19%) and diarrhea or dehydration (13%) were the common primary diagnoses. Signs that had at least a prevalence of 5% and were strong predictors for all the age categories studied were history of difficult feeding (OR 6.8 for 0-6 days, 15.1 for 2-27 days and 6.2 for 28-59 days age groups), not feeding well on observation (OR 13.7, 27.6 and 20.9 respectively for the 3 age groups), temperature > 37.5C (OR 21.8, 14.6 and 30.0 respectively for the 3 age groups) and respiratory rate > 60 per minute (OR 6.8, 15.1 and 21.0 respectively for the 3 age groups). Additional strong predictors with > 5% prevalence were history of convulsions (OR 7.9, only in 0-6 day age

  13. Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats.

    PubMed

    Allaway, David; Gilham, Matthew S; Colyer, Alison; Jönsson, Thomas J; Swanson, Kelly S; Morris, Penelope J

    2016-01-01

    Neutering is a significant risk factor for obesity in cats. The mechanisms that promote neuter-associated weight gain are not well understood but following neutering, acute changes in energy expenditure and energy consumption have been observed. Metabolic profiling (GC-MS and UHPLC-MS-MS) was used in a longitudinal study to identify changes associated with age, sexual development and neutering in male cats fed a nutritionally-complete dry diet to maintain an ideal body condition score. At eight time points, between 19 and 52 weeks of age, fasted blood samples were taken from kittens neutered at either 19 weeks of age (Early Neuter (EN), n = 8) or at 31 weeks of age (Conventional Neuter (CN), n = 7). Univariate and multivariate analyses were used to compare plasma metabolites (n = 370) from EN and CN cats. Age was the primary driver of variance in the plasma metabolome, including a developmental change independent of neuter group between 19 and 21 weeks in lysolipids and fatty acid amides. Changes associated with sexual development and its subsequent loss were also observed, with differences at some time points observed between EN and CN cats for 45 metabolites (FDR p<0.05). Pathway Enrichment Analysis also identified significant effects in 20 pathways, dominated by amino acid, sterol and fatty acid metabolism. Most changes were interpretable within the context of male sexual development, and changed following neutering in the CN group. Felinine metabolism in CN cats was the most significantly altered pathway, increasing during sexual development and decreasing acutely following neutering. Felinine is a testosterone-regulated, felid-specific glutathione derivative secreted in urine. Alterations in tryptophan, histidine and tocopherol metabolism observed in peripubertal cats may be to support physiological functions of glutathione following diversion of S-amino acids for urinary felinine secretion.

  14. Neuromuscular, metabolic and hormonal profiles of young tennis players and untrained boys.

    PubMed

    Mero, A; Jaakkola, L; Komi, P V

    1989-01-01

    This study compared the neuromuscular, metabolic and hormonal profiles of trained prepubescent tennis players and an untrained group. The boys in the experimental group (n = 9; mean age +/- S.D. = 11.4 +/- 0.5 years) had participated in tennis training for 2.3 +/- 1.0 years and the boys in the control group (n = 9; mean age +/- S.D. = 10.9 +/- 0.4 years) were normal active volunteers. The tennis players were found to be physically more active than the controls when the comparison was made for either 1 year (4.9 +/- 1.8 vs 2.6 +/- 2.5 times per week; P less than 0.05) or for 1 week (3.4 +/- 1.2 vs 0.4 +/- 0.5 times; P less than 0.001) preceding the tests. Choice reaction time was significantly (P less than 0.01) shorter in the experimental group (258 +/- 16 ms) than in the control group (344 +/- 81 ms). Dropping height in the best drop jump was significantly (P less than 0.05) higher in the tennis players (0.46 +/- 0.19 m) than in the control boys (0.27 +/- 0.10 m). The tennis players had significantly lower oxygen consumption at the 'anaerobic threshold' than the controls (P less than 0.05). There were no significant differences between the groups in serum hormone levels. The small differences that existed may have been caused by active participation in sport by the tennis players.

  15. Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats

    PubMed Central

    Allaway, David; Gilham, Matthew S.; Colyer, Alison; Jönsson, Thomas J.; Swanson, Kelly S.; Morris, Penelope J.

    2016-01-01

    Neutering is a significant risk factor for obesity in cats. The mechanisms that promote neuter-associated weight gain are not well understood but following neutering, acute changes in energy expenditure and energy consumption have been observed. Metabolic profiling (GC-MS and UHPLC-MS-MS) was used in a longitudinal study to identify changes associated with age, sexual development and neutering in male cats fed a nutritionally-complete dry diet to maintain an ideal body condition score. At eight time points, between 19 and 52 weeks of age, fasted blood samples were taken from kittens neutered at either 19 weeks of age (Early Neuter (EN), n = 8) or at 31 weeks of age (Conventional Neuter (CN), n = 7). Univariate and multivariate analyses were used to compare plasma metabolites (n = 370) from EN and CN cats. Age was the primary driver of variance in the plasma metabolome, including a developmental change independent of neuter group between 19 and 21 weeks in lysolipids and fatty acid amides. Changes associated with sexual development and its subsequent loss were also observed, with differences at some time points observed between EN and CN cats for 45 metabolites (FDR p<0.05). Pathway Enrichment Analysis also identified significant effects in 20 pathways, dominated by amino acid, sterol and fatty acid metabolism. Most changes were interpretable within the context of male sexual development, and changed following neutering in the CN group. Felinine metabolism in CN cats was the most significantly altered pathway, increasing during sexual development and decreasing acutely following neutering. Felinine is a testosterone-regulated, felid-specific glutathione derivative secreted in urine. Alterations in tryptophan, histidine and tocopherol metabolism observed in peripubertal cats may be to support physiological functions of glutathione following diversion of S-amino acids for urinary felinine secretion. PMID:27942045

  16. Musculoskeletal health profile for elite female footballers versus untrained young women before and after 16 weeks of football training.

    PubMed

    Jackman, Sarah R; Scott, Suzanne; Randers, Morten Bredsgaard; Orntoft, Christina; Blackwell, Jamie; Zar, Abdossaleh; Helge, Eva Wulff; Mohr, Magni; Krustrup, Peter

    2013-01-01

    We investigated the musculoskeletal health profile of elite female football players (ET) in comparison to untrained (UT) young women subjected to 16 weeks of football training (2 × 1 h per week). DXA scans, blood sampling, sprint testing and Flamingo postural balance testing were carried out for 27 Danish national team players and 28 untrained women, with eight women being tested after training. At baseline total BMD and BMC were 13% (1.305 ± 0.050 versus 1.159 ± 0.056 g · cm(-2)) and 23% (3047 ± 235 versus 2477 ± 526 g) higher (P <0.001) and leg BMD and BMC were 24 and 28% higher (P <0.01) in ET than in UT. Resting plasma osteocalcin was 45% higher in ET than in UT (28.8 ± 10.9 versus 19.9 ± 9.9 µg · L(-1), P <0.05). Total lean body mass was 14% higher (50.4 ± 3.3 versus 44.3 ± 4.0 kg) in ET compared with UT, with no difference in total body mass. The number of Flamingo test falls was 56-63% less (P <0.01) and 30 m sprinting speed was 31% faster (P <0.001) in ET than UT. After 16 weeks of football training for UT, lean body mass increased by 1.4 ± 0.5 kg and the number of left leg falls decreased by 29% (P <0.05). No significant changes occurred in BMD or BMC, but plasma osteocalcin increased (P <0.05) by 37%. In summary, elite women footballers have an impressive musculoskeletal health profile compared with untrained controls, but short-term football training seems to reduce the risk of falls and increase bone formation.

  17. How Informative are the Vertical Buoyancy and the Prone Gliding Tests to Assess Young Swimmers’ Hydrostatic and Hydrodynamic Profiles?

    PubMed Central

    Barbosa, Tiago M.; Costa, Mário J.; Morais, Jorge E; Moreira, Marc; Silva, António J.; Marinho, Daniel A.

    2012-01-01

    The aim of this research was to develop a path-flow analysis model to highlight the relationships between buoyancy and prone gliding tests and some selected anthropometrical and biomechanical variables. Thirty-eight young male swimmers (12.97 ± 1.05 years old) with several competitive levels were evaluated. It were assessed the body mass, height, fat mass, body surface area, vertical buoyancy, prone gliding after wall push-off, stroke length, stroke frequency and velocity after a maximal 25 [m] swim. The confirmatory model included the body mass, height, fat mass, prone gliding test, stroke length, stroke frequency and velocity. All theoretical paths were verified except for the vertical buoyancy test that did not present any relationship with anthropometrical and biomechanical variables nor with the prone gliding test. The good-of-fit from the confirmatory path-flow model, assessed with the standardized root mean square residuals (SRMR), is considered as being close to the cut-off value, but even so not suitable of the theory (SRMR = 0.11). As a conclusion, vertical buoyancy and prone gliding tests are not the best techniques to assess the swimmer’s hydrostatic and hydrodynamic profile, respectively. PMID:23486528

  18. How Informative are the Vertical Buoyancy and the Prone Gliding Tests to Assess Young Swimmers' Hydrostatic and Hydrodynamic Profiles?

    PubMed

    Barbosa, Tiago M; Costa, Mário J; Morais, Jorge E; Moreira, Marc; Silva, António J; Marinho, Daniel A

    2012-05-01

    The aim of this research was to develop a path-flow analysis model to highlight the relationships between buoyancy and prone gliding tests and some selected anthropometrical and biomechanical variables. Thirty-eight young male swimmers (12.97 ± 1.05 years old) with several competitive levels were evaluated. It were assessed the body mass, height, fat mass, body surface area, vertical buoyancy, prone gliding after wall push-off, stroke length, stroke frequency and velocity after a maximal 25 [m] swim. The confirmatory model included the body mass, height, fat mass, prone gliding test, stroke length, stroke frequency and velocity. All theoretical paths were verified except for the vertical buoyancy test that did not present any relationship with anthropometrical and biomechanical variables nor with the prone gliding test. The good-of-fit from the confirmatory path-flow model, assessed with the standardized root mean square residuals (SRMR), is considered as being close to the cut-off value, but even so not suitable of the theory (SRMR = 0.11). As a conclusion, vertical buoyancy and prone gliding tests are not the best techniques to assess the swimmer's hydrostatic and hydrodynamic profile, respectively.

  19. The Terry Fox Research Institute’s Atlantic Dialogue on patient-centred care in a personalized treatment world

    PubMed Central

    Curwin, K.; Johnston, M.; Sutcliffe, S.

    2010-01-01

    The words “personalized medicine” are used daily now in cancer care and research conversations. But what do those words really mean to us as patients, caregivers, physicians, managers of the health system, or researchers? Do we know how personalized medicine will affect us over the next decade? Are we prepared? Those and other questions are part of a continuing conversation that the Terry Fox Research Institute is having with the Canadian public in 2010 as part of its public research and outreach project, The Pan-Canadian Dialogue Series on Cancer: Let’s Get Personal. The first dialogue was held in St. John’s, Newfoundland and Labrador, April 12, to coincide with the 30th anniversary of the Terry Fox Marathon of Hope. It featured speakers and panellists from Newfoundland and Labrador, Nova Scotia, New Brunswick, and Prince Edward Island. Three core issues framed the Atlantic discussion: cancer and population health, cancer and the health system, and the science behind cancer care.

  20. Clinical Parameters vs Cytokine Profiles as Predictive Markers of IgE-Mediated Allergy in Young Children

    PubMed Central

    Lombard, Catherine; André, Floriane; Paul, Jérôme; Wanty, Catherine; Vosters, Olivier; Bernard, Pierre; Pilette, Charles; Dupont, Pierre; Sokal, Etienne M.; Smets, Françoise

    2015-01-01

    Background Allergy afflicts one third of children, negatively impacting their quality of life and generating a significant socio-economic burden. To this day, this disorder remains difficult to diagnose early in young patients, with no predictive test available. Objective This study was designed to correlate cytokine profiles with clinical phenotypes of allergy development. Methods Three hundred patients were recruited and followed from birth to 18 months of age. They were given a clinical exam at birth and at 2, 6, 12, and 18 months of age, with skin prick tests at 6, and 18 months, in order to have a record of their medical history and determine their allergic status. In addition, mononuclear cells from 131 patients were isolated from cord blood and from peripheral blood samples at 2, 6 and 18 months of age, to analyse their cytokine and chemokine production. Results Cord blood mononuclear cells (CBMCs) from future Immunoglobulin (Ig) E-mediated allergic children produced significantly less Interleukin (IL)-12p70 and IL-15 than cells from the rest of the cohort. Multivariate analyses revealed that the best predictive model of allergy was built on cytokine data, whereas the best predictive model of IgE-mediated allergy was built on clinical parameters. Conclusions and clinical relevance Although univariate analyses can yield interesting information regarding the immune responses of allergic children, finding predictive markers of the disorder will likely rely on monitoring multiple parameters. Nonetheless these analyses suggest a potential key role for IL-15 in the development of atopic disease. In addition, the study highlights the importance of clinical parameters in predicting the development of IgE-mediated allergy. PMID:26214693

  1. Supramaximal intermittent running performance in relation to age and locomotor profile in highly-trained young soccer players.

    PubMed

    Buchheit, Martin; Mendez-Villanueva, Alberto

    2013-01-01

    The aim of the study was to examine supramaximal intermittent running performance in highly-trained young soccer players, with regard to age and locomotor profile. Twenty-seven Under 14, 19 U16 and 16 U18 highly-trained soccer players performed an incremental intermittent running test (30-15 Intermittent Fitness Test) to assess supramaximal intermittent running performance (VIFT), an incremental running test to estimate maximal aerobic speed (VVam-Eval) and a 40-m sprint to estimate maximal sprinting speed (MSS). U16 and U18 presented very likely greater VIFT (19.2 ± 0.9, 19.7 ± 1.0 vs. 17.4 ± 0.9 km · h(-1)) and VVam-Eval (16.2 ± 0.9, 16.7 ± 1.0 vs. 14.6 ± 0.9 km · h(-1)) than U14, while there was no clear difference between U16 and U18. MSS (25.1 ± 1.6, 29.3 ± 1.6 and 31.0 ± 1.1 km · h(-1) for U14, U16 and U18) was very likely different between all groups. When data were pooled together, VIFT was very largely correlated with VVam-Eval and MSS (overall r =0.89, partial r = 0.74 and 0.29, respectively). Within-age group correlations showed that the older the players, the greater the magnitude of the correlations between VIFT and VVam-Eval (r = 0.67, 0.73 and 0.87). In conclusion, the major predictors of VIFT were, in order of importance, VVam-Eval and MSS; however, the older the players, the greater the correlations with VVam-Eval.

  2. Emerging technologies for sustainable irrigation – a tribute to the career of Terry Howell, Sr. Selected papers from the 2015 ASABE and IA irrigation symposium

    USDA-ARS?s Scientific Manuscript database

    This article is an introduction to the “Emerging Technologies in Sustainable Irrigation – A Tribute to the Career of Terry Howell, Sr.” Special Collection in this issue of Transactions ASABE and the next issue of Applied Engineering in Agriculture, consisting of 15 articles selected from 62 papers a...

  3. Effect of 12-week-long aerobic training programme on body composition, aerobic capacity, complete blood count and blood lipid profile among young women

    PubMed Central

    Nowak, Robert; Jastrzębski, Zbigniew; Zarębska, Aleksandra; Bichowska, Marta; Drobnik-Kozakiewicz, Izabela; Radzimiński, Łukasz; Leońska-Duniec, Agata; Ficek, Krzysztof; Cięszczyk, Paweł

    2015-01-01

    Background Numerous data suggest that aerobic-type exercise improves lipoprotein-lipid profiles, cardiorespiratory fitness and body composition in young women. The aim of this study was to evaluate the biological response to high-low impact aerobic fitness among young women. Materials and methods Thirty-four young women aged 22 (19-24) years were divided into three groups: underweight (N = 10), normal weight (N = 12) and overweight (N = 12). Aerobic capacity, anthropometry and body composition together with complete blood count and lipid profile were determined before and after completion of a 12-week-long training period. Results The training programme caused a significant decrease in weight (by 4.3 kg, P = 0.003), body mass index (by 1.3 kg/m2, P = 0.003), free fat mass (by 2.1 kg, P = 0.002), total body water (by 0.4 kg, P = 0.036), percentage of fat (by 3 percent points, P = 0.002), all analyzed skinfolds thicknesses, as well as the lipid profile in overweight group, and no changes in normal weight group. Significant changes in weight (by 4.2 kg, P = 0.005), body mass index (by 0.9 kg/m2, P = 0.005), crus skinfold thickness (by 3.3 mm, P = 0.028), and in maximum oxygen uptake (by 2.49 mL/kg/min; P = 0.047) were observed among underweight women. No change in total blood count was observed in all groups. Conclusion Twelve-week-long fitness training programme of two alternating styles (low and high impact) has a beneficial effect on overweight young women. PMID:25672474

  4. Effect of 12-week-long aerobic training programme on body composition, aerobic capacity, complete blood count and blood lipid profile among young women.

    PubMed

    Kostrzewa-Nowak, Dorota; Nowak, Robert; Jastrzębski, Zbigniew; Zarębska, Aleksandra; Bichowska, Marta; Drobnik-Kozakiewicz, Izabela; Radzimiński, Łukasz; Leońska-Duniec, Agata; Ficek, Krzysztof; Cięszczyk, Paweł

    2015-01-01

    Numerous data suggest that aerobic-type exercise improves lipoprotein-lipid profiles, cardiorespiratory fitness and body composition in young women. The aim of this study was to evaluate the biological response to high-low impact aerobic fitness among young women. Thirty-four young women aged 22 (19-24) years were divided into three groups: underweight (N=10), normal weight (N=12) and overweight (N=12). Aerobic capacity, anthropometry and body composition together with complete blood count and lipid profile were determined before and after completion of a 12-week-long training period. The training programme caused a significant decrease in weight (by 4.3 kg, P=0.003), body mass index (by 1.3 kg/m2, P=0.003), free fat mass (by 2.1 kg, P=0.002), total body water (by 0.4 kg, P=0.036), percentage of fat (by 3 percent points, P=0.002), all analyzed skinfolds thicknesses, as well as the lipid profile in overweight group, and no changes in normal weight group. Significant changes in weight (by 4.2 kg, P=0.005), body mass index (by 0.9 kg/m2, P=0.005), crus skinfold thickness (by 3.3 mm, P=0.028), and in maximum oxygen uptake (by 2.49 mL/kg/min; P=0.047) were observed among underweight women. No change in total blood count was observed in all groups. Twelve-week-long fitness training programme of two alternating styles (low and high impact) has a beneficial effect on overweight young women.

  5. Quality of life of young clinical doctors in public hospitals in China's developed cities as measured by the Nottingham Health Profile (NHP).

    PubMed

    Liang, Ying; Wang, Hanwei; Tao, Xiaojun

    2015-09-24

    In contemporary Chinese society, obstacles such as frequent violence against medical workers and tense doctor-patient relationships affect the health of Chinese doctors. This study attempted to explore the quality of life (QOL) of young clinical doctors in public hospitals in China's developed cities to study the psychometric properties of QOL and related risk factors of doctors' health. This study sampled young doctors aged 15-45 in 18 public hospitals of three cities in East China (Shanghai, Nanjing, and Hangzhou, N = 762). The Nottingham Health Profile was used to measure QOL, the dependent variable of this study. Methodologies such as reliability analysis, mean comparison, and exploratory factor analysis were used to study related psychometric properties. Almost 90 % of young Chinese clinical doctors have a bachelor's degree or above. Approximately 70.4 % of the doctors have relatively low job titles. Among the sample, 76.1 % have a monthly income ranging from USD 326 to USD 1139, and 91.3 % work over eight hours daily. These respondents have poor sleeping habits and mental functions, but have relatively good physical functions. Being female, low education, low job title, low salary, and long work hours are factors associated with doctors' poor QOL. Regression analysis results emphasize the great effect of high education on the improvement of QOL. Young clinical doctors in public hospitals in Chinese developed cities have poor QOL. Reforms on the current medical health system, improving the working environment of doctors and relieve their occupational stress should be required.

  6. Systemic physiology and neuroapoptotic profiles in young and adult rats exposed to surgery: A randomized controlled study comprising four different anaesthetic techniques.

    PubMed

    Ibrahim, Rami Mossad; Krammer, Caspar Weel; Hansen, Tom Giedsing; Kristensen, Bjarne Winther; Vutskits, Laszlo; Sørensen, Jens Ahm

    2015-10-01

    Experimental evidence indicates that general anaesthetics can induce apoptotic neurodegeneration in the developing brain. The majority of these studies have been performed in the absence of surgery and it currently remains unclear how the presence of surgical stimuli would influence neuroapoptosis as well as systemic homeostasis. Here we explored this possibility by performing dorsal skin flap surgery in young and adult rats under four distinct currently used anaesthesia regimens. Young (21-days) and adult (2 months) male Sprague-Dawley rats were randomized to 150 min exposure to one of four anaesthetics regimens: (i) sevoflurane/dexmedetomidine, (ii) sevoflurane/fentanyl; (iii) propofol/dexmedetomidine, and (iv) propofol/fentanyl. Animals underwent a dorsal skin flap procedure while physiologic, metabolic and biochemical parameters were closely monitored. Neuroapoptotic profiles were evaluated in the cortex, thalamus and hippocampus (CA1 and CA3) at the end of the procedure in each experimental group. Significant perturbations of systemic homeostasis were found under all anaesthetic regimens. Hyperglycemia and decreased heart rate were particularly relevant in experimental groups receiving dexmedetomidine, while propofol administration was associated with increased systemic lactate levels and metabolic acidosis. A substantial difference in anaesthesia/surgery-induced neuroapoptosis was found between young and adult rats in several brain regions. Combination of sevoflurane and dexmedetomidine resulted in the highest number of caspase-3 positive cells, although the extent of cell death remained relatively low in all experimental groups. Combination of anaesthesia and surgery induces significant perturbations of physiological parameters in both young and adult spontaneously breathing rats undergoing surgery. These observations further enlighten the need for detailed physiological monitoring under these experimental conditions. Although some statistically significant

  7. Comparison of total phenolic content, scavenging activity and HPLC-ESI-MS/MS profiles of both young and mature leaves and stems of Andrographis paniculata.

    PubMed

    Chua, Lee Suan; Yap, Ken Choy; Jaganath, Indu Bala

    2013-12-01

    The total phenolic content and radical scavenging activity of Andrographis paniculata has been investigated to estimate the amount of phenolic compounds and diterpene lactones, respectively in the plant extracts. The stem extracts exhibited higher total phenolic content and scavenging activity than those of the leaf extracts from both young and mature plants. A range of 19.6-47.8 mg extract of A. paniculata from different parts of the plant is equivalent to the scavenging activity exhibited by one mg of standard Trolox. HPLC-ESI-MS/MS was also used to identify simultaneously the phytochemicals from the leaves and stems of both young and mature plant samples. Of the identified compounds, seven of the sixteen diterpene lactones, three of the six flavonoids, five of the six phenolic acids and two cyclic acids are reported here for the first time for this species. Multivariate statistical approaches such as Hierarchiral Component Analysis (HCA) and Principle Component Analysis (PCA) have clustered the plant extracts into the leaf and stem groups, regardless of plant age. Further classification based on the phytochemical profiles revealed that mostly phenolic acids and flavonoids were from the young leaf extracts, and diterpenoids and their glycosides from the mature leaf extracts. However, the phytochemical profiles for the stems of both young and mature plants were not significantly different as presented in the dendrogram of HCA and the score plot of PCA. The marker for mature plants might be the m/z 557 ion (dihydroxyl dimethyl 19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide), whereas the m/z 521 ion (propyl neoandrographolide) could be the marker for leaf extracts.

  8. Parent PDD behavior inventory profiles of young children classified according to autism diagnostic observation schedule-generic and autism diagnostic interview-revised criteria.

    PubMed

    Cohen, Ira L; Gomez, Tina Rovito; Gonzalez, Maripaz G; Lennon, Elizabeth M; Karmel, Bernard Z; Gardner, Judith M

    2010-02-01

    Quantitative variations in score profiles from the parent version of the PDD Behavior Inventory (PDDBI) were examined in young Autism and PDD-NOS groups defined by ADOS-G and ADI-R criteria, relative to a not spectrum (NS) group of similar age. Both the Autism and the PDD-NOS group profiles markedly differed from the NS group. The most sensitive measures of group differences were those domain and composite scores that assessed social communication competence, as well as the overall Autism Composite score. Sensitivity, specificity and positive and negative predictability measures were quite good for these measures. It was concluded that the PDDBI is useful in assisting in the differential diagnosis of autism spectrum disorder.

  9. Exploring the role of knowledge of condition and psycho-social profiles of young people with epilepsy during transition.

    PubMed

    Gray, Victoria; Palmer, Lucy; Whelby, Kayleigh; Vinten, Jacqui; Gait, Lucy

    2017-08-01

    Transitioning from paediatric to adult care can be a particularly challenging time for young people with epilepsy and research has shown that there are a range of factors which may influence a young person's ability to successfully cope with this difficult time. The following study aimed to explore the psychosocial characteristics of this transitioning population, as well as investigate how knowledgeable the young person and their parent/carer are of their own condition throughout transition. Young people with epilepsy were recruited from two specialist epilepsy clinics in the North West and allocated to one of three groups; Group 1 pre-transition, Group 2 transitioning, and Group 3 post-transition. Results found that the young person's knowledge increased significantly throughout transition, whilst parent/carer's knowledge decreased. In addition, anxiety was found to be significantly lower in Group 2 (transitioning group) compared to Group 1 (pre-transition) and Group 3 (post-transition) and a number of significant gender differences were also identified across the groups. The study highlights the importance of considering all relevant psychosocial factors, such as anxiety, gender and the degree of knowledge the individual holds of their own condition during the transition process in order to develop psycho-educational programmes and transition pathways. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. A Profile of Oregon Counties: Human Resources, Educational, and Economic Indicators Associated with Young Children and Families.

    ERIC Educational Resources Information Center

    Oregon State Dept. of Education, Salem. Student Services Section.

    This profile of counties in Oregon covers factors that may predispose youth to grow up at risk of dropping out of high school or not acquiring the skills needed for adult life. The profile presents data on human resources and educational and economic indicators that were collected from state agencies and organizations. For the state as a whole,…

  11. "Diversity as a Verb" in Preservice Teacher Education: Creating Spaces to Challenge the Profiling of Young Children

    ERIC Educational Resources Information Center

    Long, Susi; Volk, Dinah; López-Robertson, Julia; Haney, Mary Jade

    2014-01-01

    Profiling human beings occurs daily throughout our society, typically grounded in inaccuracies, misperceptions, and biases related to race, faith, sexual orientation, language, family structure, and other factors. This article appropriates discriminatory profiling in conjunction with conceptualization of diversity as a verb to vividly convey the…

  12. "Diversity as a Verb" in Preservice Teacher Education: Creating Spaces to Challenge the Profiling of Young Children

    ERIC Educational Resources Information Center

    Long, Susi; Volk, Dinah; López-Robertson, Julia; Haney, Mary Jade

    2014-01-01

    Profiling human beings occurs daily throughout our society, typically grounded in inaccuracies, misperceptions, and biases related to race, faith, sexual orientation, language, family structure, and other factors. This article appropriates discriminatory profiling in conjunction with conceptualization of diversity as a verb to vividly convey the…

  13. Profiling Early Socio-Communicative Development in Five Young Girls with the Preserved Speech Variant of Rett Syndrome

    ERIC Educational Resources Information Center

    Marschik, Peter B.; Kaufmann, Walter E.; Einspieler, Christa; Bartl-Pokorny, Katrin D.; Wolin, Thomas; Pini, Giorgio; Budimirovic, Dejan B.; Zappella, Michele; Sigafoos, Jeff

    2012-01-01

    Rett syndrome (RTT) is a developmental disorder characterized by regression of purposeful hand skills and spoken language, although some affected children retain some ability to speech. We assessed the communicative abilities of five young girls, who were later diagnosed with the preserved speech variant of RTT, during the pre-regression period…

  14. Expressive Language Profiles of Verbally Expressive Adolescents and Young Adults with Down Syndrome or Fragile X Syndrome

    ERIC Educational Resources Information Center

    Finestack, Lizbeth H.; Abbeduto, Leonard

    2010-01-01

    Purpose: In this study, the authors examined the expressive language abilities of a subset of highly verbally expressive adolescents and young adults with Down syndrome (DS) and those with fragile X syndrome (FXS) for evidence of syndrome-related differences. FXS gender differences were also examined in an exploratory fashion. Method: The authors…

  15. Profiling Early Socio-Communicative Development in Five Young Girls with the Preserved Speech Variant of Rett Syndrome

    ERIC Educational Resources Information Center

    Marschik, Peter B.; Kaufmann, Walter E.; Einspieler, Christa; Bartl-Pokorny, Katrin D.; Wolin, Thomas; Pini, Giorgio; Budimirovic, Dejan B.; Zappella, Michele; Sigafoos, Jeff

    2012-01-01

    Rett syndrome (RTT) is a developmental disorder characterized by regression of purposeful hand skills and spoken language, although some affected children retain some ability to speech. We assessed the communicative abilities of five young girls, who were later diagnosed with the preserved speech variant of RTT, during the pre-regression period…

  16. Early Education Quality Improvement Project Profiles of Excellence: Exemplary Programs Serving West Virginia's Young Children and Their Families.

    ERIC Educational Resources Information Center

    West Virginia Governor's Cabinet on Children and Families, Charleston.

    This document describes the 25 exemplary programs serving young children and their families in West Virginia. The programs were participating in the final stages of a process for state recognition as an exemplary program by the Early Education Quality Improvement Project Committee of the Governor's Early Childhood Implementation Commission in West…

  17. Expressive Language Profiles of Verbally Expressive Adolescents and Young Adults with Down Syndrome or Fragile X Syndrome

    ERIC Educational Resources Information Center

    Finestack, Lizbeth H.; Abbeduto, Leonard

    2010-01-01

    Purpose: In this study, the authors examined the expressive language abilities of a subset of highly verbally expressive adolescents and young adults with Down syndrome (DS) and those with fragile X syndrome (FXS) for evidence of syndrome-related differences. FXS gender differences were also examined in an exploratory fashion. Method: The authors…

  18. Seismic tomography of the Excavation Damaged Zone of the Gallery 04 in the Mont Terri Rock Laboratory

    NASA Astrophysics Data System (ADS)

    Nicollin, F.; Gibert, D.; Bossart, P.; Nussbaum, Ch.; Guervilly, C.

    2008-01-01

    An endoscopic antenna is used to perform a seismic cross-hole tomography in the Excavation Damaged Zone (EDZ) of the new G04 gallery of the Mont Terri Underground Rock Laboratory (Switzerland) excavated in Opalinus clay. More than 800 seismic traces were recorded between two vertical boreholes by combining 22 source and 48 receiver locations. A vertical area of 1.2 × 3.4 m under the floor of the gallery is investigated with a high-resolution tomography. Data with a very good quality allow to determine the traveltimes and the amplitudes of a 40kHz source wavelet propagating between the two boreholes. The analysis of the traveltimes shows that the wave velocity is homogeneous but anisotropic with a minimum value of 2490 +/- 45ms-1 in the direction normal to the bedding and a maximum of 3330 +/- 90ms-1 parallel to the bedding. The amplitude of the first arrivals strongly varies depending on the source-receiver locations, and suggesting an heterogeneous distribution of the attenuation coefficient of the seismic waves. A Bayesian inversion provides likely models of attenuation that are compared with geological observations. The areas where fractures or cracks exist in the Opalinus clay appear as highly absorbing the seismic waves.

  19. Emmanuel Levinas and the face of Terri Schiavo: bioethical and phenomenological reflections on a private tragedy and public spectacle.

    PubMed

    Dahnke, Michael D

    2012-12-01

    The controversial case of Terri Schiavo came to a close on March 31, 2005, with her death following the removal of a percutaneous endoscopic gastrostomy tube. This event followed years of controversy and social upheaval. Voices from across the entire political and cultural spectrums filled the airwaves and op-ed pages of major newspapers. Protests ensued outside of Ms. Schiavo's care facility. Ms. Schiavo's parents published videos of their daughter on the internet in an effort to prove that she was not in a vegetative state and could potentially recover. There is a certain mystery to the entire controversy given the fact that, legally, it was largely a matter of settled law. Precedent cases and legal statutes clearly set out the proper procedures and decisions to be followed in this case. Nonetheless, powerful challenges and virulent opposition to these standards arose. Through an investigation of this case as well as a comparative study of the case of Dax Cowart (in particular, the documentary depictions of Dax Cowart's case) and of a photograph by Joel-Peter Witkin, I plan to investigate the source of these social upheavals and hypothesize that they were largely the result of a phenomenological reaction to the human face.

  20. Mechanical validation of balanced cross-sections: The case of the Mont Terri anticline at the Jura front (NW Switzerland)

    NASA Astrophysics Data System (ADS)

    Caër, Typhaine; Maillot, Bertrand; Souloumiac, Pauline; Leturmy, Pascale; Frizon de Lamotte, Dominique; Nussbaum, Christophe

    2015-06-01

    Close to north-west front of the Jura thrust belt in Switzerland, the Mont Terri anticline is located at a disruption of the Muschelkalk decollement, due to a former normal fault. Numerous geological data are available thanks to a motorway tunnel cross-cutting the fold and an underground laboratory. Original field data, two geological maps, a borehole, and a highway tunnel constrain the inner structure. The anticline is characterized by an overturned frontal limb, a steep back limb, and a ramp cross-cutting older normal faults. Three geological cross-sections and three 2D kinematic models are proposed as various combinations of fault-bend folding, fault-propagation folding and detachment folding. The main motivation of this study is to illustrate how geometrical constructions can be constrained by the kinematic approach of limit analysis, which determines the optimal deformation, including faults, that verifies mechanical equilibrium and the Coulomb criterion. Matching some of the important kinematic steps assumed in each three interpretations to the optimal deformation leads us to define the compatible ranges of values of the frictional parameters. These ranges allow us to assess the likeliness of the important kinematic steps of each kinematic model. The present analysis provides a quantitative link between the assumed evolution of the internal structure, and the concomitant evolutions of the topography and of the frictional parameters.

  1. Does Drinking Location Matter? Profiles of Risky Single-Occasion Drinking by Location and Alcohol-Related Harm among Young Men.

    PubMed

    Bähler, Caroline; Dey, Michelle; Dermota, Petra; Foster, Simon; Gmel, Gerhard; Mohler-Kuo, Meichun

    2014-01-01

    In adolescents and young adults, acute consequences like injuries account for a substantial proportion of alcohol-related harm, especially in risky single-occasion (RSO) drinkers. The primary aim of the study was to characterize different drinking profiles in RSO drinkers according to drinking locations and their relationship to negative, alcohol-related consequences. The sample consisted of 2746 young men from the Cohort Study on Substance Use Risk Factors who had reported drinking six or more drinks on a single-occasion at least monthly over the preceding 12 months. Principal component analysis on the frequency and amount of drinking at 11 different locations was conducted, and 2 distinguishable components emerged: a non-party-dimension (loading high on theater/cinema, sport clubs, other clubs/societies, restaurants, and sport events) and a party-dimension (loading high on someone else's home, pubs/bars, discos/nightclubs, outdoor public places, special events, and home). Differential impacts of drinking location profiles were observed on severe negative alcohol-related consequences (SAC). Relative to those classified as low or intermediate in both dimensions, no significant difference experiencing SAC was found among those who were classified as high in the non-party-dimension only. However, those who were classified as high in the party-dimension alone or in both dimensions were more likely to experience SAC. These differential effects remained after adjusting for alcohol consumption (volume and risky single-occasion drinking), personality traits, and peer-influence [adjusted OR = 0.83 (0.68-1.02), 1.57 (1.27-1.96), and 1.72 (1.23-2.41), respectively], indicating independent effects of drinking location on SAC. The inclusion of sociodemographic factors did not alter this association. The fact that this cluster of party-dimension locations seems to predispose young men to experiencing SAC has important implications for alcohol control policies.

  2. Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac Profile.

    PubMed

    Ruiz-Hurtado, Gema; García-Prieto, Concha F; Pulido-Olmo, Helena; Velasco-Martín, Juan P; Villa-Valverde, Palmira; Fernández-Valle, María E; Boscá, Lisardo; Fernández-Velasco, María; Regadera, Javier; Somoza, Beatriz; Fernández-Alfonso, María S

    2017-01-01

    Caloric restriction (CR) ameliorates cardiac dysfunction associated with obesity. However, most of the studies have been performed under severe CR (30-65% caloric intake decrease) for several months or even years in aged animals. Here, we investigated whether mild (20% food intake reduction) and short-term (2-weeks) CR prevented the obese cardiomyopathy phenotype and improved the metabolic profile of young (14 weeks of age) genetically obese Zucker fa/fa rats. Heart weight (HW) and HW/tibia length ratio was significantly lower in fa/fa rats after 2 weeks of CR than in counterparts fed ad libitum. Invasive pressure measurements showed that systolic blood pressure, maximal rate of positive left ventricle (LV) pressure, LV systolic pressure and LV end-diastolic pressure were all significantly higher in obese fa/fa rats than in lean counterparts, which were prevented by CR. Magnetic resonance imaging revealed that the increase in LV end-systolic volume, stroke volume and LV wall thickness observed in fa/fa rats was significantly lower in animals on CR diet. Histological analysis also revealed that CR blocked the significant increase in cardiomyocyte diameter in obese fa/fa rats. High resolution magic angle spinning magnetic resonance spectroscopy analysis of the LV revealed a global decrease in metabolites such as taurine, creatine and phosphocreatine, glutamate, glutamine and glutathione, in obese fa/fa rats, whereas lactate concentration was increased. By contrast, fatty acid concentrations in LV tissue were significantly elevated in obese fa/fa rats. CR failed to restore the LV metabolomic profile of obese fa/fa rats. In conclusion, mild and short-term CR prevented an obesity-induced cardiomyopathy phenotype in young obese fa/fa rats independently of the cardiac metabolic profile.

  3. Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac Profile

    PubMed Central

    Ruiz-Hurtado, Gema; García-Prieto, Concha F.; Pulido-Olmo, Helena; Velasco-Martín, Juan P.; Villa-Valverde, Palmira; Fernández-Valle, María E.; Boscá, Lisardo; Fernández-Velasco, María; Regadera, Javier; Somoza, Beatriz; Fernández-Alfonso, María S.

    2017-01-01

    Caloric restriction (CR) ameliorates cardiac dysfunction associated with obesity. However, most of the studies have been performed under severe CR (30–65% caloric intake decrease) for several months or even years in aged animals. Here, we investigated whether mild (20% food intake reduction) and short-term (2-weeks) CR prevented the obese cardiomyopathy phenotype and improved the metabolic profile of young (14 weeks of age) genetically obese Zucker fa/fa rats. Heart weight (HW) and HW/tibia length ratio was significantly lower in fa/fa rats after 2 weeks of CR than in counterparts fed ad libitum. Invasive pressure measurements showed that systolic blood pressure, maximal rate of positive left ventricle (LV) pressure, LV systolic pressure and LV end-diastolic pressure were all significantly higher in obese fa/fa rats than in lean counterparts, which were prevented by CR. Magnetic resonance imaging revealed that the increase in LV end-systolic volume, stroke volume and LV wall thickness observed in fa/fa rats was significantly lower in animals on CR diet. Histological analysis also revealed that CR blocked the significant increase in cardiomyocyte diameter in obese fa/fa rats. High resolution magic angle spinning magnetic resonance spectroscopy analysis of the LV revealed a global decrease in metabolites such as taurine, creatine and phosphocreatine, glutamate, glutamine and glutathione, in obese fa/fa rats, whereas lactate concentration was increased. By contrast, fatty acid concentrations in LV tissue were significantly elevated in obese fa/fa rats. CR failed to restore the LV metabolomic profile of obese fa/fa rats. In conclusion, mild and short-term CR prevented an obesity-induced cardiomyopathy phenotype in young obese fa/fa rats independently of the cardiac metabolic profile. PMID:28203206

  4. A laboratory experiment for determining both the hydraulic and diffusive properties and the initial pore-water composition of an argillaceous rock sample: a test with the Opalinus clay (Mont Terri, Switzerland).

    PubMed

    Savoye, S; Michelot, J-L; Matray, J-M; Wittebroodt, Ch; Mifsud, A

    2012-02-01

    Argillaceous formations are thought to be suitable natural barriers to the release of radionuclides from a radioactive waste repository. However, the safety assessment of a waste repository hosted by an argillaceous rock requires knowledge of several properties of the host rock such as the hydraulic conductivity, diffusion properties and the pore water composition. This paper presents an experimental design that allows the determination of these three types of parameters on the same cylindrical rock sample. The reliability of this method was evaluated using a core sample from a well-investigated indurated argillaceous formation, the Opalinus Clay from the Mont Terri Underground Research Laboratory (URL) (Switzerland). In this test, deuterium- and oxygen-18-depleted water, bromide and caesium were injected as tracer pulses in a reservoir drilled in the centre of a cylindrical core sample. The evolution of these tracers was monitored by means of samplers included in a circulation circuit for a period of 204 days. Then, a hydraulic test (pulse-test type) was performed. Finally, the core sample was dismantled and analysed to determine tracer profiles. Diffusion parameters determined for the four tracers are consistent with those previously obtained from laboratory through-diffusion and in-situ diffusion experiments. The reconstructed initial pore-water composition (chloride and water stable-isotope concentrations) was also consistent with those previously reported. In addition, the hydraulic test led to an estimate of hydraulic conductivity in good agreement with that obtained from in-situ tests.

  5. A laboratory experiment for determining both the hydraulic and diffusive properties and the initial pore-water composition of an argillaceous rock sample: A test with the Opalinus clay (Mont Terri, Switzerland)

    NASA Astrophysics Data System (ADS)

    Savoye, S.; Michelot, J.-L.; Matray, J.-M.; Wittebroodt, Ch.; Mifsud, A.

    2012-02-01

    Argillaceous formations are thought to be suitable natural barriers to the release of radionuclides from a radioactive waste repository. However, the safety assessment of a waste repository hosted by an argillaceous rock requires knowledge of several properties of the host rock such as the hydraulic conductivity, diffusion properties and the pore water composition. This paper presents an experimental design that allows the determination of these three types of parameters on the same cylindrical rock sample. The reliability of this method was evaluated using a core sample from a well-investigated indurated argillaceous formation, the Opalinus Clay from the Mont Terri Underground Research Laboratory (URL) (Switzerland). In this test, deuterium- and oxygen-18-depleted water, bromide and caesium were injected as tracer pulses in a reservoir drilled in the centre of a cylindrical core sample. The evolution of these tracers was monitored by means of samplers included in a circulation circuit for a period of 204 days. Then, a hydraulic test (pulse-test type) was performed. Finally, the core sample was dismantled and analysed to determine tracer profiles. Diffusion parameters determined for the four tracers are consistent with those previously obtained from laboratory through-diffusion and in-situ diffusion experiments. The reconstructed initial pore-water composition (chloride and water stable-isotope concentrations) was also consistent with those previously reported. In addition, the hydraulic test led to an estimate of hydraulic conductivity in good agreement with that obtained from in-situ tests.

  6. Enzymatic Profile of 'Willamette' Raspberry Leaf and Fruit Affected by Prohexadione-Ca and Young Canes Removal Treatments.

    PubMed

    Dragišić Maksimović, Jelena J; Poledica, Milena M; Radivojević, Dragan D; Milivojević, Jasminka M

    2017-06-21

    The influence of growth regulator prohexadione-Ca (ProCa) concurrently with young canes removal on the modification of photosynthetic pigments content and antioxidant enzymes (peroxidase, POD; catalase, CAT; polyphenol oxidase, PPO; superoxide dismutase, SOD) activities in leaves and fruits of raspberry (Rubus idaeus L.) cultivar 'Willamette' was studied. ProCa increased while canes removal decreased chlorophylls and carotenoids content compared to control. POD, CAT, and PPO activities in leaves after removal of young canes were higher compared to control (2-4 times) which was visually confirmed for POD by isoelectrofocusing. Removal of young canes slithly increased, while ProCa significantly enhanced SOD activity in leaves compared to control (475.10 and 218.38 nkat mg(-1) prot, respectively). Pattern of SOD activity in fruit was similar as in leaf with substantial increase compared to control (about 15 times). Combination of implemented measures increased activity of all enzymes in the leaves and fruits. Our study could provide a better knowledge of the ProCa and canes removal influences on the action of enzymes in order to regulate their activities in fruit products.

  7. Mediational relations of substance use risk profiles, alcohol-related outcomes, and drinking motives among young adolescents in the Netherlands.

    PubMed

    Lammers, Jeroen; Kuntsche, Emmanuel; Engels, Rutger C M E; Wiers, Reinout W; Kleinjan, Marloes

    2013-12-01

    To examine the mediation by drinking motives of the association between personality traits (negative thinking, anxiety sensitivity, impulsivity, and sensation seeking) and alcohol frequency, binge drinking, and alcohol-related problems using a sample of students (n=3053) aged between 13 and 15, who reported lifetime use of alcohol. Structural equation modeling was used to examine the relationship between personality traits and alcohol-related outcomes. The Model Indirect approach was used to examine the hypothesized mediation by drinking motives of the association between personality traits and alcohol-related outcomes. In this study among young adolescents, coping motives, social motives and enhancement motives played a prominent mediating role between personality and the alcohol outcomes. Multi-group analyses revealed that the role of drinking motives in the relation between personality and alcohol outcomes were largely similar between the sexes, though there were some differences found for binge drinking. More specifically, for young males, enhancement motives seems to play a more prominent mediation role between personality and binge drinking, while for young females, coping motives play a more mediating role between personality and binge drinking. Few mediation associations were found for conformity motives, and no relationships were found between anxiety sensitivity and drinking motives. Already in early adolescence, personality traits are found to be associated with drinking motives, which in turn are related to alcohol use. This study provides indications that it is important to intervene in early adolescence with interventions focusing on personality traits in combination with drinking motives. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. Isotopic discrimination during litter decomposition and delta13C and delta15N soil profiles in a young artificial stand and in an old floodplain forest.

    PubMed

    Gioacchini, Paola; Masia, Andrea; Canaccini, Francesca; Boldreghini, Pietro; Tonon, Giustino

    2006-06-01

    In the present study, rates of litter decomposition and microbial biomass nitrogen were monitored over an 8-month period in a young broadleaf plantation (18 y) and in an old floodplain forest. Moreover, delta13C and delta15N temporal variations within soil profiles were evaluated at both sites. Rates of litter decomposition were higher in spring and autumn than in summer, in both forests. At the end of the observation period the percentage of original litter remaining was not statistically different between the young and the old forest and accounted for 60-70% of the original amount. Microbial biomass nitrogen in the remaining litter and the percentage of litter mass lost during decomposition were positively correlated. The difference in litter quality affected the decomposition rate and also the changes in carbon isotopic composition during the decomposition process. In contrast, 15N isotopic signatures showed a similar trend in the litter of the two forests irrespective of the litter quality. Although delta13Csoil and delta15Nsoil showed considerable temporal variation they increased with depth in the soils of both sites but their seasonal changes did not reflect those of the decomposing litter. Within the same soil horizon, both delta13C and delta15N showed similar seasonal trends in the soils of the two forests, suggesting the involvement of environmental factors acting at regional level, such as soil temperature and rainfall variations, in regulating seasonal delta13C and delta15N soil variations.

  9. Choroidal thickness profiles in myopic eyes of young adults in the Correction of Myopia Evaluation Trial cohort

    PubMed Central

    Harb, Elise; Hyman, Leslie; Gwiazda, Jane; Marsh-Tootle, Wendy; Zhang, Qinghua; Hou, Wei; Norton, Thomas T; Weise, Katherine; Dirkes, Keri; Zangwill, Linda M

    2015-01-01

    Purpose To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. Design Cross-sectional, multi-center, study Methods In addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid (RTVue) in both eyes at their last visit (14 years after baseline). Using digital calipers, two independent readers measured choroidal thickness in the right eye (left eye if poor quality; n=37) at seven locations: fovea and 750, 1500, 2250μm nasal (N) and temporal (T) to the fovea. Results Choroidal thickness measurements were available from 294/346 (85%) of imaged participants (mean age: 24.3±1.4 years; 44.9% male) with mean myopia of -5.3±2.0D and mean AL of 25.5±1.0mm. Overall, choroidal thickness varied by location (p<0.0001) and was thickest at the fovea (273.8±70.9 μm) and thinnest nasally (N2250,191.5±69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (p≤0.001) and presence of peri-papillary crescent at all locations except T1500 and T2250 (p≤0.0001). Choroidal thickness varied by ethnicity at N2250 (p<0.0001), with Asians having the thinnest and African Americans the thickest choroids. Conclusion Choroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically. PMID:25896460

  10. Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort.

    PubMed

    Harb, Elise; Hyman, Leslie; Gwiazda, Jane; Marsh-Tootle, Wendy; Zhang, Qinghua; Hou, Wei; Norton, Thomas T; Weise, Katherine; Dirkes, Keri; Zangwill, Linda M

    2015-07-01

    To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. Cross-sectional, multicenter study. In addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid in both eyes at their last visit (14 years after baseline). Using digital calipers, 2 independent readers measured choroidal thickness in the right eye (left eye if poor quality; n = 37) at 7 locations: fovea and 750, 1500, and 2250 μm nasal (N) and temporal (T) to the fovea. Choroidal thickness measurements were available from 294 of 346 (85%) imaged participants (mean age: 24.3 ± 1.4 years; 44.9% male) with mean myopia of -5.3 ± 2.0 diopters and mean AL of 25.5 ± 1.0 mm. Overall, choroidal thickness varied by location (P < .0001) and was thickest at the fovea (273.8 ± 70.9 μm) and thinnest nasally (N2250, 191.5 ± 69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (P ≤ .001) and presence of peripapillary crescent at all locations except T1500 and T2250 (P ≤ .0001). Choroidal thickness varied by ethnicity at N2250 (P < .0001), with Asians having the thinnest and African Americans the thickest choroids. Choroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. HIV-1 infection and pregnancy in young women in Brazil: socioeconomic and drug resistance profiles in a cross-sectional study.

    PubMed

    Lima, Yanna Andressa Ramos; Reis, Mônica Nogueira Guarda; Cardoso, Ludimila Paula Vaz; Stefani, Mariane Martins Araújo

    2016-07-05

    To describe socioeconomic and antiretroviral (ARV) drug resistance profiles among young pregnant women infected with HIV-1. A public health antenatal programme responsible for screening ∼90 000 pregnant women per year for nine different infectious diseases in Central Western Brazil. 96 young pregnant women (15-24 years) infected with HIV-1. Standard interviews and blood samples were taken at the time of recruitment, at the first medical appointment after confirmation of diagnosis of HIV-1 infection, and before ARV prophylaxis initiation. Clinical and laboratory data were retrieved from medical files. HIV-1 pol gene sequences (entire protease/PR, partial reverse transcriptase/RT) were obtained from plasma RNA. ARV resistance mutations (CPR/Stanford HIV-1; International AIDS Society-USA databases) were identified. The median age was 21 years; most reported <8 years education; 73% were recently diagnosed. Approximately 20% (19/96) presented late for antenatal care (after 26 gestational weeks), while 49% reported ≥2 previous pregnancies. Possible heterosexual transmission by an HIV-1 infected partner (17%) and commercial sex work (2%) were reported. The median of CD4 cell count was 526 cells/mm(3); the median viral load was: 10 056 copies/mL in ARV-naïve (48/96) patients and 5881 copies/mL in ARV-exposed (48/96) patients. Two probable seroconversion cases during pregnancy were identified in adolescents. One mother-to-child transmission case (1.0%) was observed. Transmitted drug resistance among ARV-naïve patients was 9.3% (CI 95% 3.3% to 19.6%); secondary drug resistance among ARV-exposed patients was 12.5% (CI 95% 4.7% to 25.6%). Despite high access to antenatal care, the low socioeconomic-educational profiles seen in these young HIV-1-infected women highlight the necessity of improved public health educational and preventive strategies regarding HIV infection and early unplanned pregnancy. Published by the BMJ Publishing Group Limited. For permission

  12. Genetic profiles and prediction of the success of young athletes' transition from middle- to long-distance runs: an exploratory study.

    PubMed

    Ben-Zaken, Sigal; Meckel, Yoav; Lidor, Ronnie; Nemet, Dan; Eliakim, Alon

    2013-08-01

    The aim of the study was to assess whether an aerobic-favoring genetic profile can predict the success of a shift from middle- to long-distance running. Thirteen elite middle-distance runners were divided into successful and nonsuccessful groups in their shift toward long-distance runs. All the runners began their training program at the age of 14-15, and after 6-7 years, changed focus and adjusted their training program to fit longer running distances. The participants' personal records in the longer events were set at the age of 25-27, about 3-5 years after the training readjustment took place. The endurance genetic score based on 9 polymorphisms was computed as the endurance genetic distance score (EGDS9). The power genetic distance score (PGDS5) was computed based on 5 power-related genetic polymorphisms. The mean EGDS9 was significantly higher among the successful group than the nonsuccessful group (37.1 and 23.3, respectively, p < .005, effect size 0.75), while the mean PGDS5 was not statistically different between the 2 groups (p = .13). Our findings suggest the possible use of genetic profiles as an added tool for determining appropriate competitive transition and specialization in young athletes involved in early phases of talent development.

  13. Neurocognitive profile of a young adolescent with DK phocomelia/von Voss phocomelia/von Voss Cherstvoy syndrome.

    PubMed

    Antonini, Tanya N; Van Horn Kerne, Valerie; Axelrad, Marni E; Karaviti, Lefkothea P; Schwartz, David D

    2015-07-01

    DK phocomelia/von Voss Cherstvoy syndrome is a rare condition characterized by upper limb and urogenital abnormalities and various brain anomalies. Previously reported cases have noted significant developmental delays, although no formal testing of cognitive abilities has been reported. In this paper we describe results from a comprehensive neuropsychological evaluation of a 12-year-old male with DK phocomelia syndrome. Test findings indicated mild impairment in intellectual functioning, with more significant impairment in adaptive skills and academic achievement. The neuropsychological profile converged with neurological findings, showing a distinct pattern of strengths and weaknesses that suggests functional compromise of posterior brain regions with relatively well-preserved functioning of more anterior regions. Specifically, impairments were evident in perceptual reasoning, visual perception, and visuomotor integration, whereas normal or near normal functioning was evident in memory, receptive language, social cognition, attention, and most aspects of executive functioning. To our knowledge this is the first report to describe the neurocognitive profile of an individual with DK phocomelia syndrome. © 2015 Wiley Periodicals, Inc.

  14. A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS

    PubMed Central

    Brand, Henk; Imangaliyev, Sultan; Tsivtsivadze, Evgeni; van der Weijden, Fridus; de Jong, Ad; Paauw, Armand; Crielaard, Wim; Keijser, Bart; Veerman, Enno

    2016-01-01

    A cross-sectional observational study was conducted to evaluate the inter-individual variation in the MALDI-TOF MS peptide profiles of unstimulated whole saliva in a population of 268 systemically healthy adults aged 18–30 yr (150 males and 118 females) with no apparent caries lesions or periodontal disease. Using Spectral Clustering, four subgroups of individuals were identified within the study population. These subgroups were delimited by the pattern of variation in 9 peaks detected in the 2–15 kDa m/z range. An Unsupervised Feature Selection algorithm showed that P-C peptide, a 44 residue-long salivary acidic proline-rich protein, and three of its fragments (Fr. 1–25, Fr. 15–35 and Fr. 15–44) play a central role in delimiting the subgroups. Significant differences were found in the salivary biochemistry of the subgroups with regard to lysozyme and chitinase, two enzymes that are part of the salivary innate defense system (p < 0.001). These results suggest that MALDI-TOF MS salivary peptide profiles may relate information on the underlying state of the oral ecosystem and may provide a useful reference for salivary disease biomarker discovery studies. PMID:27258023

  15. Differential Effects on the ITPA [Illinois Test of Psycholinguistic Abilities] Profile of the Final Version of the Peabody Language Development Kits (Levels #1 and #2) with Young Disadvantaged Negro Children. IMRID Papers and Reports, Volume 5, No. 24.

    ERIC Educational Resources Information Center

    Hausman, Ralph M.; Apffel, James A.

    The differential effects of the final revision of Levels 1 and 2 of the Peabody Language Development Kits (PLDK) on the Illinois Test of Psycholinguistic Abilities (ITPA) profiles of young disadvantaged black children were studied. Contrasted with 90 control subjects were 90 experimental subjects who received a daily 30-minute oral language…

  16. Neural stem cell- and neurogenesis-related gene expression profiles in the young and aged dentate gyrus.

    PubMed

    Shetty, Geetha A; Hattiangady, Bharathi; Shetty, Ashok K

    2013-12-01

    Hippocampal neurogenesis, important for memory and mood function, wanes greatly in old age. Studies in rat models have implied that this decrease is not due to loss of neural stem cells (NSCs) in the subgranular zone of the dentate gyrus (DG) but rather due to an increased quiescence of NSCs. Additional studies have suggested that changes in the microenvironment, particularly declines in the concentrations of neurotrophic factors, underlie this change. In this study, we compared the expression of 84 genes that are important for NSC proliferation and neurogenesis between the DG of young (4 months old) and aged (24 months old) Fischer 344 rats, using a quantitative real-time polymerase chain reaction array. Interestingly, the expression of a vast majority of genes that have been reported previously to positively or negatively regulate NSC proliferation was unaltered with aging. Furthermore, most genes important for cell cycle arrest, regulation of cell differentiation, growth factors and cytokine levels, synaptic functions, apoptosis, cell adhesion and cell signaling, and regulation of transcription displayed stable expression in the DG with aging. The exceptions included increased expression of genes important for NSC proliferation and neurogenesis (Stat3 and Shh), DNA damage response and NF-kappaB signaling (Cdk5rap3), neuromodulation (Adora1), and decreased expression of a gene important for neuronal differentiation (HeyL). Thus, age-related decrease in hippocampal neurogenesis is not associated with a decline in the expression of selected genes important for NSC proliferation and neurogenesis in the DG.

  17. Profiling early socio-communicative development in five young girls with the preserved speech variant of Rett syndrome.

    PubMed

    Marschik, Peter B; Kaufmann, Walter E; Einspieler, Christa; Bartl-Pokorny, Katrin D; Wolin, Thomas; Pini, Giorgio; Budimirovic, Dejan B; Zappella, Michele; Sigafoos, Jeff

    2012-01-01

    Rett syndrome (RTT) is a developmental disorder characterized by regression of purposeful hand skills and spoken language, although some affected children retain some ability to speech. We assessed the communicative abilities of five young girls, who were later diagnosed with the preserved speech variant of RTT, during the pre-regression period (aged 12-24 months). Videotapes, obtained by parents during routine family situations and celebrations, were analyzed to identify communicative forms and functions used by these toddlers. Non-verbal communicative forms dominated over verbal-communicative forms for six of the eight identified communication functions. Although the girls used various non-verbal forms to make requests, for example, none of the individuals were observed to make choices or request information. Early peculiarities in the speech-language domain during the first year of life became more prominent and evident during the second year of life as general differences between typical development and atypical development become more obvious in RTT. These findings highlight the importance of assessing socio-communicative forms and functions at early age in children with RTT. The results suggest that speech-language functions did not appear to play a major role in the children's communicative attempts. We conclude that, even among children with the preserved speech variant, socio-communicative deficits are present before regression and persist after this period. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Determination of the thermal conductivity of opalinus clay via simulations of experiments performed at the Mont Terri underground laboratory

    NASA Astrophysics Data System (ADS)

    Mügler, C.; Filippi, M.; Montarnal, Ph.; Martinez, J.-M.; Wileveau, Y.

    2006-02-01

    Storage in deep geological formations is a potential solution for the management of high-level radioactive wastes. In this context, different types of rocks such as argillite are extensively studied. In the Mont Terri underground laboratory (Switzerland), several experiments have been performed in order to characterize the properties of the opalinus clay. One of these experiments, called HE-C, has consisted in measuring in situ the time evolution of the rock temperature submitted to a heating source. Experimental measurements have shown that the thermal behaviour of the clay was not homogeneous around the borehole where the heater was installed. Furthermore, 3D direct numerical simulations of this experiment performed with the code Cast3M have proved that it was necessary to introduce a new parameter α to model the amount of electric power lost in cables and by air convection inside the metallic tube containing the heater. A numerical simulation-optimization technique has been used to estimate the thermal longitudinal and transverse conductivities ( λ// and λ⊥) of the host rock. It consists in minimizing an objective function that is the sum of the squared differences between measured and calculated temperatures. But this method induced a lot of Cast3M simulations. In order to drastically reduce the CPU time, we used a neural network approximation built from a sample training of 1100 Cast3M simulations. It allowed us to calculate the objective function for 500 000 different values of the triplet ( λ//, λ⊥, α). Finally, we obtained the following values for the thermal conductivities on one side of the borehole, λ// = 1.84 ± 0.04 W m - 1 K - 1 and λ⊥ = 0.55 ± 0.03 W m - 1 K - 1 ; on the other side, λ// = 1.90 ± 0.07 W m - 1 K - 1 and λ⊥ = 1.07 ± 0.09 W m - 1 K - 1 . The estimated thermal conductivities λ⊥ perpendicular to the bedding plane are quite different. It is perhaps caused by the presence of an intensive fractured zone on one side of

  19. Excavation Induced Hydraulic Response of Opalinus Clay - Investigations of the FE-Experiment at the Mont Terri URL in Switzerland

    NASA Astrophysics Data System (ADS)

    Vogt, T.; Müller, H. R.; Garitte, B.; Sakaki, T.; Vietor, T.

    2013-12-01

    The Full-Scale Emplacement (FE) Experiment at the Mont Terri underground research laboratory in Switzerland is a full-scale heater test in a clay-rich formation (Opalinus Clay). Based on the Swiss disposal concept it simulates the construction, emplacement, backfilling, and post-closure thermo-hydro-mechanical (THM) evolution of a spent fuel / vitrified high-level waste (SF / HLW) repository tunnel in a realistic manner. The main aim of this experiment is to investigate SF / HLW repository-induced THM coupled effects mainly in the host rock but also in the engineered barrier system (EBS), which consists of bentonite pellets and blocks. A further aim is to gather experience with full-scale tunnel construction and associated hydro-mechanical (HM) processes in the host rock. The entire experiment implementation (in a 50 m long gallery with approx. 3 m diameter) as well as the post-closure THM evolution will be monitored using a network of several hundred sensors (state-of-the-art sensors and measurement systems as well as fiber-optic sensors). The sensors are distributed in the host rock's near- and far-field, the tunnel lining, the EBS, and on the heaters. The heater emplacement and backfilling has not started yet, therefore only the host rock instrumentation is installed at the moment and is currently generating data. We will present the instrumentation concept and rationale as well as the first monitoring results of the excavation and ventilation phase. In particular, we investigated the excavation induced hydraulic response of the host rock. Therefore, the spatiotemporal evolution of porewater-pressure time series was analyzed to get a better understanding of HM coupled processes during and after the excavation phase as well as the impact of anisotropic geomechanic and hydraulic properties of the clay-rich formation on its hydraulic behavior. Excavation related investigations were completed by means of inclinometer data to characterize the non-elastic and time

  20. Childhood CBCL bipolar profile and adolescent/young adult personality disorders: a 9-year follow-up.

    PubMed

    Halperin, Jeffrey M; Rucklidge, Julia J; Powers, Robyn L; Miller, Carlin J; Newcorn, Jeffrey H

    2011-04-01

    To assess the late adolescent psychiatric outcomes associated with a positive Child Behavior Checklist-Juvenile Bipolar Disorder Phenotype (CBCL-JBD) in children diagnosed with ADHD and followed over a 9-year period. Parents of 152 children diagnosed as ADHD (ages 7-11 years) completed the CBCL. Ninety of these parents completed it again 9 years later as part of a comprehensive evaluation of Axis I and II diagnoses as assessed using semi-structured interviews. As previously proposed, the CBCL-JBD phenotype was defined as T-scores of 70 or greater on the Attention Problems, Aggression, and Anxiety/Depression subscales. The CBCL-JBD phenotype was found in 31% of those followed but only 4.9% of the sample continued to meet the phenotype criteria at follow-up. Only two of the sample developed Bipolar Disorder by late adolescence and only one of those had the CBCL-JBD profile in childhood. The proxy did not predict any Axis I disorders. However, the CBCL-JBD proxy was highly predictive of later personality disorders. Only a subgroup of the original childhood sample was followed. Given this sample was confined to children with ADHD, it is not known whether the prediction of personality disorders from CBCL scores would generalize to a wider community or clinical population. A positive CBCL-JBD phenotype profile in childhood does not predict Axis I Disorders in late adolescence; however, it may be prognostic of the emergence of personality disorders. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers

    PubMed Central

    Shi, Bing; Gao, Hongmin; Zhang, Tianyang; Cui, Qinghua

    2016-01-01

    Cigarette smoking is a world-wide habit and an important risk factor for cancer. It was known that cigarette smoking can change the expression of circulating microRNAs (miRNAs) in healthy middle-aged adults. However, it remains unclear whether cigarette smoking can change the levels of circulating miRNAs in young healthy smokers and whether there are differences in cancer susceptibility for the two cases. In this study, the miRNA expression profiles of 28 smokers and 12 non-smokers were determined by Agilent human MicroRNA array. We further performed bioinformatics analysis for the differentially expressed miRNAs. The result showed that 35 miRNAs were differentially expressed. Among them, 24 miRNAs were up-regulated and 11 miRNAs were down-regulated in smokers. Functional enrichment analysis showed that the deregulated miRNAs are related to immune system and hormones regulation. Strikingly, the up-regulated miRNAs are mostly associated with hematologic cancers, such as lymphoma, leukemia. As a comparison, the up-regulated plasma miRNAs in middle-aged smokers are mostly associated with solid cancers, such as hepatocellular carcinoma and lung cancer, suggesting that smoking could have different influences on young adults and middle-aged adults. In a conclusion, we identified the circulating miRNAs deregulated by cigarette smoking and revealed that the age-dependent deregulated miRNAs tend to be mainly involved in different types of human cancers. PMID:26943588

  2. Extracellular matrix profiles in the progression to heart failure. European Young Physiologists Symposium Keynote Lecture-Bratislava 2007.

    PubMed

    Graham, H K; Horn, M; Trafford, A W

    2008-09-01

    The myocardial extracellular matrix (ECM), which preserves the geometry and integrity of the myocardium, is a dynamic structure whose component proteins are maintained by a finely controlled homeostatic balance between deposition and degradation. One of the key targets in cardiology is the elucidation of the molecular mechanisms which mediate pathological remodelling of this matrix causing the transition from compensatory hypertrophy to congestive decompensated heart failure. In response to injury or increased workload, cardiac remodelling including myocyte hypertrophy, develops as the heart attempts to compensate for increased wall stresses. Persistence of these stresses over extended time periods leads to disruption of ECM homeostasis resulting in irreversible maladaptive cardiac remodelling, ventricular dilatation and finally heart failure. ECM remodelling is regulated by the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs). Clinical studies and experimental models of cardiac disease states have reported alterations in the balance between the MMPs and TIMPs in the failing heart and crucially at intermediate time points in the progression to failure. This article reviews the recent clinical, genetic and experimental approaches employed to compare ECM, MMP and TIMP profiles in healthy, compensated and failing hearts and identifies common themes in the perturbation of ECM homeostasis in the transition to heart failure.

  3. Physical and Flavor Characteristics, Fatty Acid Profile, Antioxidant Status and Nrf2-Dependent Antioxidant Enzyme Gene Expression Changes in Young Grass Carp (Ctenopharyngodon idella) Fillets Fed Dietary Valine

    PubMed Central

    Jiang, Wei-Dan; Liu, Yang; Wu, Pei; Jiang, Jun; Kuang, Sheng-Yao; Tang, Ling; Tang, Wu-Neng; Zhang, Yong-An; Zhou, Xiao-Qiu

    2017-01-01

    This study was conducted to examine the effects of dietary valine on the physical and flavor characteristics, fatty acid (FA) profile, antioxidant status and Nrf2-dependent antioxidant enzyme gene expression in the muscle of young grass carp (Ctenopharyngodon idella) fed increasing levels of valine (4.3, 8.0, 10.6, 13.1, 16.9 and 19.1 g/kg) for 8 weeks. Compared with the control group, the group fed valine showed improved physical characteristics of fish fillets (increased relative shear force, hydroxyproline, protein and lipid levels and decreased cathepsin B and L activities, as well as cooking loss, were observed). Moreover, valine improved the flavor of young grass carp fillets by increasing the amino acid (AA) concentration in fish muscle (increased aspartic acid, threonine, glutamine, cystine, methionine, leucine, tyrosine, phenylalanine, lysine, histidine, arginine and valine concentrations were observed). Additionally, optimal valine supplementation increased the potential health benefits to humans by decreasing the saturated FA (C15:0 and C16:0) concentration and increasing the unsaturated FA (monounsaturated FAs (MUFAs), such as C16:1, C18:1c+t and C20:1, and polyunsaturated FAs (PUFAs), such as C18:3n-3, C20:2 and C22:6) concentration. In addition, the reduced glutathione (GSH) content and the activities of Cu/Zn superoxide dismutase (SOD1), catalase (CAT) and Selenium-dependent glutathione peroxydase (Se-GPx) increased under valine supplementation (P < 0.05). Furthermore, the SOD1, CAT and Se-GPx mRNA levels increased with dietary valine levels, possibly due to the up-regulation of NF-E2-related factor 2 (Nrf2), target of rapamycin (TOR) and ribosomal protein S6 kinase 1 (S6K1) and the down-regulation of Kelch-like-ECH-associated protein 1 (Keap1) in muscle (P < 0.05). In conclusion, valine improved the physical and flavor characteristics, FA profile, and antioxidant status and regulated the expression of the antioxidant enzyme genes Nrf2, Keap1, TOR

  4. Physical and Flavor Characteristics, Fatty Acid Profile, Antioxidant Status and Nrf2-Dependent Antioxidant Enzyme Gene Expression Changes in Young Grass Carp (Ctenopharyngodon idella) Fillets Fed Dietary Valine.

    PubMed

    Luo, Jian-Bo; Feng, Lin; Jiang, Wei-Dan; Liu, Yang; Wu, Pei; Jiang, Jun; Kuang, Sheng-Yao; Tang, Ling; Tang, Wu-Neng; Zhang, Yong-An; Zhou, Xiao-Qiu

    2017-01-01

    This study was conducted to examine the effects of dietary valine on the physical and flavor characteristics, fatty acid (FA) profile, antioxidant status and Nrf2-dependent antioxidant enzyme gene expression in the muscle of young grass carp (Ctenopharyngodon idella) fed increasing levels of valine (4.3, 8.0, 10.6, 13.1, 16.9 and 19.1 g/kg) for 8 weeks. Compared with the control group, the group fed valine showed improved physical characteristics of fish fillets (increased relative shear force, hydroxyproline, protein and lipid levels and decreased cathepsin B and L activities, as well as cooking loss, were observed). Moreover, valine improved the flavor of young grass carp fillets by increasing the amino acid (AA) concentration in fish muscle (increased aspartic acid, threonine, glutamine, cystine, methionine, leucine, tyrosine, phenylalanine, lysine, histidine, arginine and valine concentrations were observed). Additionally, optimal valine supplementation increased the potential health benefits to humans by decreasing the saturated FA (C15:0 and C16:0) concentration and increasing the unsaturated FA (monounsaturated FAs (MUFAs), such as C16:1, C18:1c+t and C20:1, and polyunsaturated FAs (PUFAs), such as C18:3n-3, C20:2 and C22:6) concentration. In addition, the reduced glutathione (GSH) content and the activities of Cu/Zn superoxide dismutase (SOD1), catalase (CAT) and Selenium-dependent glutathione peroxydase (Se-GPx) increased under valine supplementation (P < 0.05). Furthermore, the SOD1, CAT and Se-GPx mRNA levels increased with dietary valine levels, possibly due to the up-regulation of NF-E2-related factor 2 (Nrf2), target of rapamycin (TOR) and ribosomal protein S6 kinase 1 (S6K1) and the down-regulation of Kelch-like-ECH-associated protein 1 (Keap1) in muscle (P < 0.05). In conclusion, valine improved the physical and flavor characteristics, FA profile, and antioxidant status and regulated the expression of the antioxidant enzyme genes Nrf2, Keap1, TOR

  5. Reduced coenzyme Q10 in female smokers and its association with lipid profile in a young healthy adult population

    PubMed Central

    Al-Bazi, Maha M.; Elshal, Mohamed F.

    2011-01-01

    Introduction Cigarette smoking has a negative effect on body reserve of antioxidants and cholesterol metabolism. Coenzyme Q10 (CoQ10), a potent antioxidant synthesized as part of the cholesterol pathway, is a potential biomarker for systemic oxidative stress. We aimed to investigate gender variation in plasma lipid profile and CoQ10 concentrations in healthy non-smokers and in smokers. Material and methods The study included 55 cigarette smokers (25 females and 30 males) and 51 non-smokers (25 females and 26 males) with the age range from 21 to 45 years, and who had no history of alcohol abuse or chronic diseases such as diabetes mellitus or obesity. Coenzyme Q10 plasma concentrations were measured by reverse-phase high performance liquid chromatography (HPLC) with ultraviolet detection. Fasting plasma glucose and lipid levels were determined by standard colorimetric methods. Results Our results showed that CoQ10 concentrations were significantly decreased in smokers, especially in females, than their non-smoker counterparts. Female smokers also exhibited a significant decrease in plasma concentrations of total cholesterol (TC), HDL-C, LDL-C, and atherogenic ratios HDL-C/TC and CoQ10/LDL-C than male counterparts. Plasma triglyceride concentrations were increased in smokers irrespective of gender. Plasma CoQ10 was relatively more associated with TC and LDL-C in female smokers than male smokers. Conclusions The adverse effects of smoking on body reserve of antioxidants and cholesterol metabolism are greater in females than in males, partially as a result of decreased CoQ10 plasma concentrations, HDL-C and total-cholesterol and abnormal atherogenicity indices. PMID:22328876

  6. Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women: a randomized, placebo-controlled, double-blind, crossover trial

    PubMed Central

    Kim, Jungmi; Cha, Yong-Jun; Lee, Kyung-Hea

    2013-01-01

    The consumption of fruits and vegetables that have high polyphenol content has been previously associated with a reduced risk for cardiovascular disease. We investigated the effects of onion peel extract on plasma total antioxidant capacity, lipid peroxidation, and leukocyte DNA damage. This study was a randomized, double-blind, placebo-controlled, crossover trial. Healthy female subjects received either onion peel extract or placebo (dextrin) for two weeks, underwent a 1-week washout period, and then received the other treatment for an additional two weeks. After two weeks of onion peel extract supplementation, the total cholesterol level, low-density lipoprotein cholesterol level, and atherogenic index significantly decreased (P < 0.05). No changes were observed in activities of erythrocyte antioxidant enzymes or levels of lipid peroxidation markers following onion peel extract supplementation. Additionally, no significant difference was found in plasma antioxidant vitamin (retinol, tocopherols, carotenoids, and coenzyme Q10) levels or ex vivo H2O2-provoked oxidative DNA damage after onion peel extract supplementation. The present interventional study provides evidence of the health benefits of onion peel extract and demonstrates its effects in modulating lipid profiles in healthy young Korean women. PMID:24133616

  7. BRAF(V600E) mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl.

    PubMed

    Mitsutake, Norisato; Fukushima, Toshihiko; Matsuse, Michiko; Rogounovitch, Tatiana; Saenko, Vladimir; Uchino, Shinya; Ito, Masahiro; Suzuki, Keiji; Suzuki, Shinichi; Yamashita, Shunichi

    2015-11-20

    After the accident at the Fukushima Daiichi Nuclear Power Plant, the thyroid ultrasound screening program for children aged 0-18 at the time of the accident was started from October 2011. The prevalence of thyroid carcinomas in that population has appeared to be very high (84 cases per 296,253). To clarify the pathogenesis, we investigated the presence of driver mutations in these tumours. 61 classic papillary thyroid carcinomas (PTCs), two follicular variant PTCs, four cribriform-morular variant PTCs and one poorly-differentiated thyroid carcinoma were analysed. We detected BRAF(V600E) in 43 cases (63.2%), RET/PTC1 in six (8.8%), RET/PTC3 in one (1.5%) and ETV6/NTRK3 in four (5.9%). Among classic and follicular variant PTCs, BRAF(V600E) was significantly associated with the smaller size. The genetic pattern was completely different from post-Chernobyl PTCs, suggesting non-radiogenic etiology of these cancers. This is the first study demonstrating the oncogene profile in the thyroid cancers discovered by large mass screening, which probably reflects genetic status of all sporadic and latent tumours in the young Japanese population. It is assumed that BRAF(V600E) may not confer growth advantage on paediatric PTCs, and many of these cases grow slowly, suggesting that additional factors may be important for tumour progression in paediatric PTCs.

  8. BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl

    PubMed Central

    Mitsutake, Norisato; Fukushima, Toshihiko; Matsuse, Michiko; Rogounovitch, Tatiana; Saenko, Vladimir; Uchino, Shinya; Ito, Masahiro; Suzuki, Keiji; Suzuki, Shinichi; Yamashita, Shunichi

    2015-01-01

    After the accident at the Fukushima Daiichi Nuclear Power Plant, the thyroid ultrasound screening program for children aged 0–18 at the time of the accident was started from October 2011. The prevalence of thyroid carcinomas in that population has appeared to be very high (84 cases per 296,253). To clarify the pathogenesis, we investigated the presence of driver mutations in these tumours. 61 classic papillary thyroid carcinomas (PTCs), two follicular variant PTCs, four cribriform-morular variant PTCs and one poorly-differentiated thyroid carcinoma were analysed. We detected BRAFV600E in 43 cases (63.2%), RET/PTC1 in six (8.8%), RET/PTC3 in one (1.5%) and ETV6/NTRK3 in four (5.9%). Among classic and follicular variant PTCs, BRAFV600E was significantly associated with the smaller size. The genetic pattern was completely different from post-Chernobyl PTCs, suggesting non-radiogenic etiology of these cancers. This is the first study demonstrating the oncogene profile in the thyroid cancers discovered by large mass screening, which probably reflects genetic status of all sporadic and latent tumours in the young Japanese population. It is assumed that BRAFV600E may not confer growth advantage on paediatric PTCs, and many of these cases grow slowly, suggesting that additional factors may be important for tumour progression in paediatric PTCs. PMID:26584635

  9. Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women: a randomized, placebo-controlled, double-blind, crossover trial.

    PubMed

    Kim, Jungmi; Cha, Yong-Jun; Lee, Kyung-Hea; Park, Eunju

    2013-10-01

    The consumption of fruits and vegetables that have high polyphenol content has been previously associated with a reduced risk for cardiovascular disease. We investigated the effects of onion peel extract on plasma total antioxidant capacity, lipid peroxidation, and leukocyte DNA damage. This study was a randomized, double-blind, placebo-controlled, crossover trial. Healthy female subjects received either onion peel extract or placebo (dextrin) for two weeks, underwent a 1-week washout period, and then received the other treatment for an additional two weeks. After two weeks of onion peel extract supplementation, the total cholesterol level, low-density lipoprotein cholesterol level, and atherogenic index significantly decreased (P < 0.05). No changes were observed in activities of erythrocyte antioxidant enzymes or levels of lipid peroxidation markers following onion peel extract supplementation. Additionally, no significant difference was found in plasma antioxidant vitamin (retinol, tocopherols, carotenoids, and coenzyme Q10) levels or ex vivo H2O2-provoked oxidative DNA damage after onion peel extract supplementation. The present interventional study provides evidence of the health benefits of onion peel extract and demonstrates its effects in modulating lipid profiles in healthy young Korean women.

  10. Meal frequency changes the basal and time-course profiles of plasma nutrient concentrations and affects feed efficiency in young growing pigs.

    PubMed

    Le Naou, T; Le Floc'h, N; Louveau, I; van Milgen, J; Gondret, F

    2014-05-01

    Ingested dietary nutrients and feed energy are partitioned among tissues to sustain body growth. Based on the respective costs of the various metabolic pathways allowing use and storage of feed energy into cells, it may be theorized that daily meal frequency could affect growth, body composition or feed efficiency. This study aimed to determine the effects of daily meal frequency on nutrient partitioning, tissue metabolism and composition, and performance. Young growing pigs (30 kg BW) were offered a same amount of feed either in 2 (M2, n = 15) or 12 (M12, n = 16) meals per day during a 3-wk interventional period. Animals fed twice a day had an accelerated weight gain (+6.4%, P < 0.05) and exhibited a greater G:F (+4%, P = 0.03) than animals fed 12 meals per day during this period. Basal plasma concentrations of glucose, lactate, triglyceride, urea, and leptin were lower (P < 0.001) in M2 pigs than in M12 pigs. Meal frequency also changed (P < 0.001) the time-course profiles of plasma concentrations of glucose, insulin, and lactate in response to meal ingestion. A greater rise and a sharper fall in plasma glucose and insulin levels were observed in M2 pigs compared with M12 pigs. In both groups, similarities were observed in the postprandial time courses of plasma concentrations of insulin and of α-amino nitrogen (used as a measure of total AA). Despite these metabolic responses, tissue lipids, glycogen content, and enzyme activities participating in energy metabolism in muscle and liver were similar (P > 0.10) in both groups at the end of the trial. Percentage of perirenal fat in the body and depth of dorsal subcutaneous fat tissue were not affected by meal frequency, but kidney weight was lower (-18%, P < 0.001) in M2 pigs than in M12 pigs. Altogether, the less frequent daily meal intake improves the conversion of feed into weight gain, without marked modifications of tissue composition in young pigs.

  11. Monitoring the Excavation Damaged Zone in Opalinus clay by three dimensional reconstruction of the electrical resistivity in the Mont Terri gallery G-04

    NASA Astrophysics Data System (ADS)

    Lesparre, N.; Adler, A.; Nicollin, F.; Gibert, D.; Nussbaum, C.

    2012-04-01

    The characteristics of opalinus clay have been studied in the last years for its capacity to retain radionuclide transport as a low permeable rock. This formation presents thereby suitable properties for hosting repository sites of radioactive waste. The Mont Terri underground rock laboratory (Switzerland) has been excavated in opalinus clay layer in order to develop experiences improving the knowledge on the physico-chemical properties of the rock. The study of electrical properties furnishes information on the rock structure, its anisotropy and the changes of these properties with time (Nicollin et al., 2010 ; Thovert et al., 2011). Here the three dimensional reconstruction of the electrical resistivity aims at monitoring the temporal evolution of the excavation damaged zone. Three rings of electrodes have been set-up around the gallery and voltage is measured between two electrodes while a current is injected between two others (Gibert et al., 2006). Measurements have been achieved from July 2004 until April 2008 before, during and after the excavation of the gallery 04. In this study we develop a computational approach to reconstruct three dimensional images of the resistivity in the vicinity of the electrodes. A finite element model is used to represent the complex geometry of the gallery. The measurements inferred from a given resistivity distribution are estimated using the software EIDORS (Adler and Lionheart, 2006), this constitutes the forward problem. The reconstruction of the media resistivity is then implemented by fitting the estimated to the measured data, via the resolution of an inverse problem. The parameters of this inverse problem are defined by mapping the forward problem elements into a coarser mesh. This allows to reduce drastically the number of unknowns and so increases the robustness of the inversion. The inversion is executed with the conjugate gradient method regularised by an analysis of the Jacobian singular values. The results show an

  12. Racial and Ethnic Profiles of Complementary and Alternative Medicine Use Among Young Adults in the United States: Findings From the National Longitudinal Study of Adolescent Health.

    PubMed

    Upchurch, Dawn M; Wexler Rainisch, Bethany K

    2012-10-01

    This study describes complementary and alternative medicine use among a national sample of young adults, with an emphasis on characterizing racial and ethnic differences, highlighting variation across subgroups of Hispanics. The authors examined young adults ages 18 to 27 years (n = 14 128) from wave III (2001-2002) of the National Longitudinal Study of Adolescent Health. Prevalence estimates and logistic regression results were weighted and adjusted for complex sample design. The study examined recent complementary and alternative medicine use in the past 12 months, recent use for each of 15 specific complementary and alternative medicine modalities, and the 5 most commonly used modalities (herbs, massage, chiropractic, relaxation, and vitamins). Results showed that 29% of young adults aged 18 to 27 years recently used complementary and alternative medicine. Prevalence was highest among Cuban Americans (42%) and lowest among blacks (22%). Young adults used a diversity of complementary and alternative medicine modalities and there were substantial differences in use across racial and ethnic groups.

  13. A preliminary identification and determination of characteristic volatile organic compounds from cotton, polyester and terry-towel by headspace solid phase microextraction gas chromatography-mass spectrometry.

    PubMed

    Stapleton, Katherine; Dean, John R

    2013-06-21

    Analysis of fifteen volatile organic compounds previously associated with laundry malodour has been investigated using headspace solid phase microextraction gas chromatography-mass spectrometry. Limits of detection (all determined on a 25 cm(2) area of fabric) ranged from a low of 0.4 ng (for guaiacol) through to a high of 28 ng (for 3-methylindole) on cotton; values on polyester ranged from a low of 0.7 ng (for dimethyl trisulfide) through to a high of 37 ng (for 3-methylindole); and, values on terry-towel ranged from a low of 1.7 ng (for guaiacol) through to a high of 157 ng (for ethyl benzene). There was a lack of correlation between the level of malodour and the occurrence of any of the VOCs detected; it could be that other compounds not evaluated in this study are responsible for malodour or it could be a collaborative effect of the various compounds studied. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Modelling the Mont Terri HE-D experiment for the Thermal–Hydraulic–Mechanical response of a bedded argillaceous formation to heating

    DOE PAGES

    Garitte, B.; Nguyen, T. S.; Barnichon, J. D.; ...

    2017-05-09

    Coupled thermal–hydrological–mechanical (THM) processes in the near field of deep geological repositories can influence several safety features of the engineered and geological barriers. Among those features are: the possibility of damage in the host rock, the time for re-saturation of the bentonite, and the perturbations in the hydraulic regime in both the rock and engineered seals. Within the international cooperative code-validation project DECOVALEX-2015, eight research teams developed models to simulate an in situ heater experiment, called HE-D, in Opalinus Clay at the Mont Terri Underground Research Laboratory in Switzerland. The models were developed from the theory of poroelasticity in ordermore » to simulate the coupled THM processes that prevailed during the experiment and thereby to characterize the in situ THM properties of Opalinus Clay. The modelling results for the evolution of temperature, pore water pressure, and deformation at different points are consistent among the research teams and compare favourably with the experimental data in terms of trends and absolute values. The models were able to reproduce the main physical processes of the experiment. In particular, most teams simulated temperature and thermally induced pore water pressure well, including spatial variations caused by inherent anisotropy due to bedding.« less

  15. Evaluation of the predictive capability of coupled thermo-hydro-mechanical models for a heated bentonite/clay system (HE-E) in the Mont Terri Rock Laboratory

    DOE PAGES

    Garitte, B.; Shao, H.; Wang, X. R.; ...

    2017-01-09

    Process understanding and parameter identification using numerical methods based on experimental findings are a key aspect of the international cooperative project DECOVALEX. Comparing the predictions from numerical models against experimental results increases confidence in the site selection and site evaluation process for a radioactive waste repository in deep geological formations. In the present phase of the project, DECOVALEX-2015, eight research teams have developed and applied models for simulating an in-situ heater experiment HE-E in the Opalinus Clay in the Mont Terri Rock Laboratory in Switzerland. The modelling task was divided into two study stages, related to prediction and interpretation ofmore » the experiment. A blind prediction of the HE-E experiment was performed based on calibrated parameter values for both the Opalinus Clay, that were based on the modelling of another in-situ experiment (HE-D), and modelling of laboratory column experiments on MX80 granular bentonite and a sand/bentonite mixture .. After publication of the experimental data, additional coupling functions were analysed and considered in the different models. Moreover, parameter values were varied to interpret the measured temperature, relative humidity and pore pressure evolution. The analysis of the predictive and interpretative results reveals the current state of understanding and predictability of coupled THM behaviours associated with geologic nuclear waste disposal in clay formations.« less

  16. Plutonium interaction studies with the Mont Terri Opalinus Clay isolate Sporomusa sp. MT-2.99: changes in the plutonium speciation by solvent extractions.

    PubMed

    Moll, Henry; Cherkouk, Andrea; Bok, Frank; Bernhard, Gert

    2017-04-07

    Since plutonium could be released from nuclear waste disposal sites, the exploration of the complex interaction processes between plutonium and bacteria is necessary for an improved understanding of the fate of plutonium in the vicinity of such a nuclear waste disposal site. In this basic study, the interaction of plutonium with cells of the bacterium, Sporomusa sp. MT-2.99, isolated from Mont Terri Opalinus Clay, was investigated anaerobically (in 0.1 M NaClO4) with or without adding Na-pyruvate as an electron donor. The cells displayed a strong pH-dependent affinity for Pu. In the absence of Na-pyruvate, a strong enrichment of stable Pu(V) in the supernatants was discovered, whereas Pu(IV) polymers dominated the Pu oxidation state distribution on the biomass at pH 6.1. A pH-dependent enrichment of the lower Pu oxidation states (e.g., Pu(III) at pH 6.1 which is considered to be more mobile than Pu(IV) formed at pH 4) was observed in the presence of up to 10 mM Na-pyruvate. In all cases, the presence of bacterial cells enhanced removal of Pu from solution and accelerated Pu interaction reactions, e.g., biosorption and bioreduction.

  17. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort.

    PubMed

    Yeung, Roseanne O; Zhang, Yuying; Luk, Andrea; Yang, Wenying; Sobrepena, Leorino; Yoon, Kun-Ho; Aravind, S R; Sheu, Wayne; Nguyen, Thy Khue; Ozaki, Risa; Deerochanawong, Chaicharn; Tsang, Chiu Chi; Chan, Wing-Bun; Hong, Eun Gyoung; Do, Trung Quan; Cheung, Yu; Brown, Nicola; Goh, Su Yen; Ma, Ronald C; Mukhopadhyay, Monojitketan; Ojha, Arvind Kumar; Chakraborty, Shaibal; Kong, Alice P; Lau, Winnie; Jia, Weiping; Li, Wenhui; Guo, Xiaohui; Bian, Rongwen; Weng, Jianping; Ji, Linong; Reyes-dela Rosa, Mercedes; Toledo, Ronaldo M; Himathongkam, Thep; Yoo, Soon-Jib; Chow, C C; Ho, Larry L T; Chuang, Lee-Ming; Tutino, Greg; Tong, Peter C; So, Wing-Yee; Wolthers, Troels; Ko, Gary; Lyubomirsky, Greg; Chan, Juliana C N

    2014-12-01

    The prevalence of diabetes is increasing in young adults in Asia, but little is known about metabolic control or the burden of associated complications in this population. We assessed the prevalence of young-onset versus late-onset type 2 diabetes, and associated risk factors and complication burdens, in the Joint Asia Diabetes Evaluation (JADE) cohort. JADE is an ongoing prospective cohort study. We enrolled adults with type 2 diabetes from 245 outpatient clinics in nine Asian countries or regions. We classified patients as having young-onset diabetes if they were diagnosed before the age of 40 years, and as having late-onset diabetes if they were diagnosed at 40 years or older. Data for participants' first JADE assessment was extracted for cross-sectional analysis. We compared clinical characteristics, metabolic risk factors, and the prevalence of complications between participants with young-onset diabetes and late-onset diabetes. Between Nov 1, 2007, and Dec 21, 2012, we enrolled 41,029 patients (15,341 from Hong Kong, 9107 from India, 7712 from Philippines, 5646 from China, 1751 from South Korea, 705 from Vietnam, 385 from Singapore, 275 from Thailand, 107 from Taiwan). 7481 patients (18%) had young-onset diabetes, with age at diagnosis of mean 32·9 years [SD 5·7] versus 53·9 years [9·0] with late-onset diabetes (n=33,548). Those with young-onset diabetes had longer disease duration (median 10 years [IQR 3-18]) than those with late-onset diabetes (5 years [2-11]). Fewer patients with young-onset diabetes achieved HbA1c concentrations lower than 7% compared to those with late-onset diabetes (27% vs 42%; p<0·0001) Patients with young-onset diabetes had higher mean concentrations of HbA1c (mean 8·32% [SD 2·03] vs 7·69% [1·82]; p<0·0001), LDL cholesterol (2·78 mmol/L [0·96] vs 2·74 [0·93]; p=0·009), and a higher prevalence of retinopathy (1363 [20%] vs 5714 (18%); p=0·011) than those with late-onset diabetes, but were less likely to receive statins

  18. [WISC-IV performances of young male subjects with AD(H)D, the benefits of applying cognitive profile analysis to diagnostics].

    PubMed

    Walg, Marco; Bowi, Ulrike; El-Wahsch, Daniel

    2016-01-01

    Studies suggest that children and adolescents suffering from AD(H)D show a specific WISC-IV profile in comparison to subjects of the same age group without any mental disorder. The present study compares the cognitive profiles of male subjects with AD(H)D to those of a clinical control group. The benefits of applying an ADHD specific cognitive profile analysis to differential diagnostics are analyzed. The WISC-IV profiles of 50 male subjects with AD(H)D (8 to 15 years) were compared with the profiles of 54 male children and adolescents(7 to 16 years) with other mental disorders. In addition, subgroup differences within the AD(H)D group were investigated. Subjects with AD(H)D showed a significant lower processing speed than the control group. Within the AD(H)D group, patients with ADD showed the lowest speed index. There were no group differences in total IQ and other WISC-IV indexes. A WISC-IV profile analysis is not a suitable instrument to certainly confirm or exclude an AD(H)D diagnosis. Nevertheless, the results of the present study speak for considering the WISC-IV profile in the diagnosis of AD(H)D as it increases the sensitivity of the clinical diagnostic process and provides useful indicators for differential diagnosis.

  19. Young People outside the Labour Force and Full-Time Education: Activities and Profiles. Longitudinal Surveys of Australian Youth. Research Report 45

    ERIC Educational Resources Information Center

    Hillman, Kylie

    2005-01-01

    This report focuses on a group of young people who are not involved in full-time education or the labour force, that is, they are not studying full-time, nor are they working or looking for work. The data used in this report are drawn from the Longitudinal Surveys of Australian Youth (LSAY), which studies the progress of cohorts of young…

  20. Racial and Ethnic Profiles of Complementary and Alternative Medicine Use Among Young Adults in the United States: Findings From the National Longitudinal Study of Adolescent Health

    PubMed Central

    Upchurch, Dawn M.; Wexler Rainisch, Bethany K.

    2013-01-01

    This study describes complementary and alternative medicine use among a national sample of young adults, with an emphasis on characterizing racial and ethnic differences, highlighting variation across subgroups of Hispanics. The authors examined young adults ages 18 to 27 years (n = 14 128) from wave III (2001–2002) of the National Longitudinal Study of Adolescent Health. Prevalence estimates and logistic regression results were weighted and adjusted for complex sample design. The study examined recent complementary and alternative medicine use in the past 12 months, recent use for each of 15 specific complementary and alternative medicine modalities, and the 5 most commonly used modalities (herbs, massage, chiropractic, relaxation, and vitamins). Results showed that 29% of young adults aged 18 to 27 years recently used complementary and alternative medicine. Prevalence was highest among Cuban Americans (42%) and lowest among blacks (22%). Young adults used a diversity of complementary and alternative medicine modalities and there were substantial differences in use across racial and ethnic groups. PMID:23869288

  1. The Toileting Habit Profile Questionnaire: Screening for Sensory-Based Toileting Difficulties in Young Children with Constipation and Retentive Fecal Incontinence

    ERIC Educational Resources Information Center

    Beaudry-Bellefeuille, Isabelle; Lane, Shelly J.; Ramos-Polo, Eduardo

    2016-01-01

    This study examined the face and preliminary content validity of the Toileting Habit Profile Questionnaire, a tool designed to screen for sensory-based defecation difficulties in children. A panel of experts reviewed a pilot version of the questionnaire and responded to probe questions. Two reviewers conducted direct content analysis of responses;…

  2. The Toileting Habit Profile Questionnaire: Screening for Sensory-Based Toileting Difficulties in Young Children with Constipation and Retentive Fecal Incontinence

    ERIC Educational Resources Information Center

    Beaudry-Bellefeuille, Isabelle; Lane, Shelly J.; Ramos-Polo, Eduardo

    2016-01-01

    This study examined the face and preliminary content validity of the Toileting Habit Profile Questionnaire, a tool designed to screen for sensory-based defecation difficulties in children. A panel of experts reviewed a pilot version of the questionnaire and responded to probe questions. Two reviewers conducted direct content analysis of responses;…

  3. Micronutrient intakes, micronutrient status and lipid profiles among young people consuming different amounts of breakfast cereals: further analysis of data from the National Diet and Nutrition Survey of Young People aged 4 to 18 years.

    PubMed

    Gibson, Sigrid

    2003-12-01

    To examine associations between breakfast cereal consumption and the dietary habits, nutrient intakes and nutritional status of young people, considering both nutrient adequacy and safety issues (fortification). Using archived data from 1688 children in the (British) National Diet and Nutrition Survey of Young People aged 4 to 18 years, nutrient intakes and status were compared across thirds of breakfast cereal consumption (T1 to T3), adjusted for age and energy intake. Cereals provided on average 2%, 6% and 12% of energy in T1, T2 and T3, respectively, for boys; 1%, 4% and 10%, respectively, for girls. Intakes of iron, B vitamins and vitamin D were around 20-60% higher in T3 compared with T1, with significant linear relationships observed for iron, thiamin, riboflavin and folate (T1

  4. Mood and Performance in Young Malaysian Karateka

    PubMed Central

    Wong, Rebecca S. K.; Thung, Jin Seng; Pieter, Willy

    2006-01-01

    In an attempt to test the conceptual model by Lane and Terry, the purposes of this study were 1) to assess mood states in non-depressed and depressed young karate athletes; 2) to assess mood states in relation to performance in young karate athletes. The participants were recruited from the 2004 Malaysian Games (72 males, 19.20 ± 1.16 years; 37 females, 18.78 ± 0.88 years). The athletes were divided into winners (medalists) and losers. The Brunel Mood Scale (BRUMS) was administered prior to the start of competition. MANOVA was employed to treat the data, while Pearson correlations were calculated for mood states in each depressed mood group and by gender. In terms of non-depressed and depressed mood, tension in the females was higher in the depressed group (5.61 ± 3.02 vs. 3.11 ± 1.90, p = 0.026, eta2 = 0.133), as was fatigue (3.64 ± 2.61 vs. 0.89 ± 1.69, p = 0.006, eta2 = 0.199). Tension in the males was higher in the depressed group (4.41 ± 2.52 vs. 1.50 ± 1.55, p < 0.001, eta2 = 0.215), as was anger (1.43 ± 1.88 vs. 0.25 ± 1.00, p = 0.019, eta2 = 0.076). The highest associations among mood subscales were between anger and depression (r = 0.57), and between depression and fatigue ( r = 0.55) in depressed males. The female winning karateka scored higher on anger (3.08 ± 2.96 vs. 1.29 ± 2.24, p = 0.046, eta2 = 0.109). The highest correlations between mood dimensions in depressed females were between depression and anger (r = 0.85) and between depression and confusion (r = 0.85). Contrary to previous research on the influence of depression on anger, only the female winners scored higher on anger. Several negative mood dimensions were higher in both male and female depressed groups, lending some support to the conceptual model advanced by Lane and Terry. Key Points To date, there is no information about the relationship between mood and martial arts performance in Malaysian athletes. There might be cultural differences in the way Malaysian athletes

  5. Observations of fault zone heterogeneity effects on stress alteration and slip nucleation during a fault reactivation experiment in the Mont Terri rock laboratory, Switzerland

    NASA Astrophysics Data System (ADS)

    Nussbaum, C.; Guglielmi, Y.

    2016-12-01

    The FS experiment at the Mont Terri underground research laboratory consists of a series of controlled field stimulation tests conducted in a fault zone intersecting a shale formation. The Main Fault is a secondary order reverse fault that formed during the creation of the Jura fold-and-thrust belt, associated to a large décollement. The fault zone is up to 6 m wide, with micron-thick shear zones, calcite veins, scaly clay and clay gouge. We conducted fluid injection tests in 4 packed-off borehole intervals across the Main Fault using mHPP probes that allow to monitor 3D displacement between two points anchored to the borehole walls at the same time as fluid pressure and flow rate. While pressurizing the intervals above injection pressures of 3.9 to 5.3 MPa, there is an irreversible change in the displacements magnitude and orientation associated to the hydraulic opening of natural shear planes oriented N59 to N69 and dipping 39 to 58°. Displacements of 0.01 mm to larger than 0.1 mm were captured, the highest value being observed at the interface between the low permeable fault core and the damage zone. Contrasted fault movements were observed, mainly dilatant in the fault core, highly dilatant-normal slip at the fault core-damage zone interface and low dilatant-strike-slip-reverse in the damage-to-intact zones. First using a slip-tendency approach based on Coulomb reactivation potential of fault planes, we computed a stress tensor orientation for each test. The input parameters are the measured displacement vectors above the hydraulic opening pressure and the detailed fault geometry of each intervals. All measurements from the damage zone can be explained by a stress tensor in strike-slip regime. Fault movements measured at the core-damage zone interface and within the fault core are in agreement with the same stress orientations but changed as normal faulting, explaining the significant dilatant movements. We then conducted dynamic hydromechanical simulations

  6. The relative contributions of psychiatric symptoms and psychotropic medications on the sleep-wake profile of young persons with anxiety, depression and bipolar disorders.

    PubMed

    Robillard, Rébecca; Oxley, Cristal; Hermens, Daniel F; White, Django; Wallis, Ryan; Naismith, Sharon L; Whitwell, Bradley; Southan, James; Scott, Elizabeth M; Hickie, Ian B

    2016-09-30

    This study investigated the relative contribution of psychiatric symptoms and psychotropic medications on the sleep-wake cycle. Actigraphy and clinical assessments (Brief Psychiatric Rating Scale) were conducted in 146 youths with anxiety, depression or bipolar disorders. Independently of medications, mania symptoms were predictive of lower circadian amplitude and rhythmicity. Independently of diagnosis and symptoms severity: i) antipsychotics were related to longer sleep period and duration, ii) serotonin-norepinephrine reuptake inhibitors to longer sleep period, and iii) agomelatine to earlier sleep onset. Manic symptoms and different subclasses of medications may have independent influences on the sleep-wake cycle of young people with mental disorders. Copyright © 2016. Published by Elsevier Ireland Ltd.

  7. Newly Diagnosed Colonic Adenocarcinoma: The Presenting Sign in a Young Woman with Undiagnosed Crohn's Disease in the Absence of Primary Sclerosing Cholangitis and a Normal Microsatellite Instability Profile

    PubMed Central

    2017-01-01

    Ulcerative colitis has long been linked with an increased risk for colonic adenocarcinoma, whereas Crohn's disease (CD) has recently been reported to pose a similar increased risk. We report a 33-year-old healthy female with no family history who presented with abdominal pain and a colon mass. Histopathology revealed a moderately differentiated adenocarcinoma extending through the muscularis propria with metastatic lymph nodes and intact mismatch repair proteins by immunohistochemical expression and gene sequencing. The nonneoplastic grossly uninvolved background mucosa showed marked crypt distortion, crypt abscesses, CD-like lymphoid hyperplasia, transmural inflammation, and reactive epithelial atypia. Additional patient questioning revealed frequent loose stools since she was a teenager leading to diagnosis of a previously undiagnosed CD without primary sclerosing cholangitis (PSC). The adenocarcinoma is suspected to be related to the underlying CD. Newly diagnosed adenocarcinoma in a young female as the presenting sign for CD in the absence of PSC is extremely rare. PMID:28255489

  8. Risk factor profiling and study of atherosclerotic coronary plaque burden and morphology with coronary computed tomography angiography in coronary artery disease among young Indians.

    PubMed

    Chaudhary, R; Chauhan, A; Singhal, M; Bagga, S

    2017-08-01

    With a decade earlier manifestation of coronary artery disease (CAD) and paucity of data characterizing coronary plaque with coronary computed tomography angiography (CTA) among CAD patients in India, the study aimed to analyze patient characteristics and coronary plaque burden and morphology in young Indian patients with CAD. Serial coronary CTA was performed in 96 CAD patients. Among 60 patients ≤40years, risk factor and coronary plaque analysis done using a 256- slice CT in 33 patients with acute coronary syndrome (ACS) was compared with 27 patients with chronic stable angina (CSA). Univariate and multivariate analysis was performed, for factors predicting ACS as an outcome among young CAD patients. In addition, quantitative and morphologic plaque characteristics were compared among those ≤40years and >40years. Among 60 subjects ≤40years of age, 77% had dyslipidemia, 70% high lipoprotein(a), 53.33% elevated hs-CRP and 73.33% raised homocysteine. hs-CRP (9.33 vs. 3.33, p value=0.01) and serum triglycerides (178.67 vs. 141.42, p value=0.03) were markedly raised in patients with ACS. Statistically significant number of patients in the ACS group had positive remodelling (ACS, 69.7% vs. CSA, 14.8%; p value<0.001), low attenuation plaque (ACS, 63.6% vs. CSA, 11.1%; p value<0.001), spotty calcification (ACS, 36.4% vs. CSA, 3.7%; p=0.002) and non-calcified plaque (ACS, 69.7% vs. CSA, 11.1%; p<0.001). On multivariate analysis, only lipoprotein (a) >30mg/dL and composite vulnerability score maintained a predictive value for ACS in patients ≤40years. Statistically significant number of patients in the younger age group had higher mean total plaque volume (66.17±41.31mm(3) vs. 44.94±49.07mm(3); p=0.03), remodelling index (1.5±0.27 vs. 1.08±0.38; p=0.0001). Comparing culprit lesion characteristics of ACS patients in the two age groups, positive remodelling (95.8% vs. 70.5%, p=0.02), spotty calcification (50% vs. 11.7%, p=0.01) and non-calcified plaque (95.8% vs

  9. Chemotherapy-Related Amenorrhea and Menopause in Young Chinese Breast Cancer Patients: Analysis on Incidence, Risk Factors and Serum Hormone Profiles

    PubMed Central

    Liem, Giok S.; Mo, Frankie K. F.; Pang, Elizabeth; Suen, Joyce J. S.; Tang, Nelson L. S.; Lee, Kun M.; Yip, Claudia H. W.; Tam, Wing H.; Ng, Rita; Koh, Jane; Yip, Christopher C. H.; Kong, Grace W. S.; Yeo, Winnie

    2015-01-01

    Purpose In this prospective cross-sectional study on young premenopausal breast cancer patients, the objectives were to: determine the incidences of chemotherapy-related amenorrhea (CRA) and menopause (CRM); identify associated factors; and assess plasma levels of estradiol (E2) and follicular stimulating hormone (FSH) among patients who developed menopause. Methods Eligibility criteria include Chinese stage I-III breast cancer patients, premenopausal, age ≤45 at breast cancer diagnosis, having received adjuvant chemotherapy, within 3–10 years after breast cancer diagnosis. Detailed menstrual history prior to and after adjuvant treatment was taken at study entry. Patients’ background demographics, tumor characteristics and anti-cancer treatments were collected. The rates of CRA and CRM were determined. Analysis was conducted to identify factors associated with CRM. For postmenopausal patients, levels of E2 and FSH were analyzed. Results 286 patients were recruited; the median time from breast cancer diagnosis to study entry was 5.0 years. 255 patients (91.1%) developed CRA. Of these, 66.7% regained menstruation. At the time of study entry, 137 (48.9%) had developed CRM, amongst whom 84 were age ≤45. On multivariate analysis, age was the only associated factor. Among patients with CRM, the median FSH was 41.0 IU/L; this was significantly lower in those who were taking tamoxifen compared to those who were not (20.1 vs. 59.7 IU/L, p<0.0001). The E2 level was <40 pmol/L; there was no difference between those who were still on tamoxifen or not. Conclusion After adjuvant chemotherapy, the majority of young Chinese breast cancer patients developed CRA; ~50% developed CRM, with 61% at age ≤45. Age at diagnosis is the only factor associated with CRM. FSH level may be affected by tamoxifen intake. PMID:26485568

  10. Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study.

    PubMed

    Raitoharju, Emma; Seppälä, Ilkka; Oksala, Niku; Lyytikäinen, Leo-Pekka; Raitakari, Olli; Viikari, Jorma; Ala-Korpela, Mika; Soininen, Pasi; Kangas, Antti J; Waldenberger, Melanie; Klopp, Norman; Illig, Thomas; Leiviskä, Jaana; Loo, Britt-Marie; Hutri-Kähönen, Nina; Kähönen, Mika; Laaksonen, Reijo; Lehtimäki, Terho

    2014-06-25

    Since metabolic syndrome (MetS) is a collection of cardiovascular risk factors involving multiple signaling systems, we related the metabolic abnormalities associated with MetS with circulating microRNA profiles to pinpoint the affected signaling pathways. The blood microRNA profile, genome wide gene expression and serum NMR metabolomics were analyzed from 71 participants of the Young Finns Study. We found nine microRNAs that associated significantly with metabolites connected to MetS. MicroRNA-144-5p concentration correlated with glucose levels, hsa-1207-5p with glycosylated hemoglobin and hsa-miR-484 with metabolites related to insulin resistance. Hsa-miR-625-3p correlated with cholesterol levels, hsa-miR-1237-3p and hsa-miR-331-3p expression with certain fatty acids levels and hsa-miR-129-1-3p, -129-2-3p, and -1288-3p with glycerol levels. The down-regulated targets of miR-1207-5p and -129-2-3p were enriched in PI3K and MAPK pathways and 8 out of the 12 enriched pathways were down-regulated in individuals with MetS. In conclusion microRNAs associated with several aspects of MetS, possibly regulating glucose and lipid metabolism. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. [Effect of deltaran on the mediatory balance in the brain of young and old rats with left-side laterality profile in case of carotid arteries occlusion].

    PubMed

    Kim, T K; Karantysh, G V; Mendzheritskiĭ, A M; Ryzhak, G A

    2007-01-01

    The medico-social significance of ischemic brain lesions, which are the most frequent cause of disablement and death in older people, stipulates the need for efficient means of prevention and correction of central nervous system disorders in case of ischemic brain lesions. The efficacy of Deltaran in the correction of disordered neuromediator balance in the brain of rats of different age groups was studied on the model of carotid arteries occlusion. Studies showed, that Deltaran exerts an anti-stress effect on old rats with left-side profile by altering the neuromediators' distribution in animals' brain under conditions of hypoxia. This enables to recommend Deltaran for further study as a neuroprotector.

  12. Expression Profiling of the 14-3-3 Gene Family in Response to Salt Stress and Potassium and Iron Deficiencies in Young Tomato (Solanum lycopersicum) Roots: Analysis by Real-time RT–PCR

    PubMed Central

    XU, WEI FENG; SHI, WEI MING

    2006-01-01

    • Background and Aims Mineral nutrient deficiencies and salinity constitute major limitations for crop plant growth on agricultural soils. 14-3-3 proteins are phosphoserine-binding proteins that regulate the activities of a wide array of targets via direct protein–protein interactions and may play an important role in responses to mineral nutrients deficiencies and salt stress. In the present study, the expression profiling of the 14-3-3 gene family in response to salt stress and potassium and iron deficiencies in young tomato (Solanum lycopersicum) roots was investigated in order to analyse the 14-3-3 roles of the proteins in these abiotic stresses. • Methods Sequence identities and phylogenetic tree creation were performed using DNAMAN version 4.0 (Lynnon Biosoft Company). Real-time RT–PCR was used to examine the expression of each 14-3-3 gene in response to salt stress and potassium and iron deficiencies in young tomato roots. • Key Results The phylogenetic tree shows that the 14-3-3 gene family falls into two major groups in tomato plants. By using real-time RT–PCR, it was found that (a) under normal growth conditions, there were significant differences in the mRNA levels of 14-3-3 gene family members in young tomato roots and (b) 14-3-3 proteins exhibited diverse patterns of gene expression in response to salt stress and potassium and iron deficiencies in tomato roots. • Conclusions The results suggest that (a) 14-3-3 proteins may be involved in the salt stress and potassium and iron deficiency signalling pathways in young tomato roots, (b) the expression pattern of 14-3-3 gene family members in tomato roots is not strictly related to the position of the corresponding proteins within a phylogenetic tree, (c) gene-specific expression patterns indicate that isoform-specificity may exist in the 14-3-3 gene family of tomato roots, and (d) 14-3-3 proteins (TFT7) might mediate cross-talk between the salt stress and potassium and iron

  13. Perceived trajectories of life satisfaction across past, present, and future: profiles and correlates of subjective change in young, middle-aged, and older adults.

    PubMed

    Röcke, Christina; Lachman, Margie E

    2008-12-01

    Despite longitudinal stability in subjective well-being across adulthood, many adults perceive self-related change. This study was aimed at identifying differential subjective change profiles in life satisfaction rated for the present, the past, and the future and to examine their associations with sociodemographic variables and changes in adaptive functioning. The authors addressed this aim using Midlife in the United States survey data from 2 measurement occasions (N=3,631; age at Time 1: 24-75). A cluster analysis was used to identify a continuous high subgroup and an incremental subgroup at both occasions. A 3rd subgroup was labeled present low at Time 1 and decremental at Time 2. Although the average pattern across individual variables suggested stability, up to 60% of individuals fit profiles depicting perceived change, and some individuals changed subgroup membership over time. After controlling for sociodemographic characteristics, subgroups differed in level and change in biopsychosocial measures of adaptive functioning, with sense of control and social relationship quality showing stronger associations than personality and physical health. Results indicate that a person-centered approach to assessing life satisfaction provides a rich and dynamic picture of individual differences in subjective well-being across the adult life span. Copyright (c) 2009 APA, all rights reserved.

  14. Perceived Trajectories of Life Satisfaction Across Past, Present, and Future: Profiles and Correlates of Subjective Change in Young, Middle-Aged, and Older Adults

    PubMed Central

    Röcke, Christina; Lachman, Margie E.

    2010-01-01

    Despite longitudinal stability in subjective well-being across adulthood, many adults perceive self-related change. This study was aimed at identifying differential subjective change profiles in life satisfaction rated for the present, the past, and the future and to examine their associations with sociodemographic variables and changes in adaptive functioning. We addressed this aim using Midlife in the United States survey data from two measurement occasions (N=3631, T1-age: 24-75). Using cluster analysis, a ‘Continuous High,’ and an ‘Incremental’ subgroup were identified at both occasions. A third subgroup was labeled ‘Present Low’ at T1 and ‘Decremental’ at T2. Although the average pattern across individual variables suggested stability, up to 60% of individuals fit profiles depicting perceived change, and some individuals changed subgroup membership over time. After controlling for sociodemographic characteristics, subgroups differed in level and change in biopsychosocial measures of adaptive functioning, with sense of control and social relationship quality showing stronger associations than personality and physical health. Results indicate that a person-centered approach to assessing life satisfaction provides a rich and dynamic picture of individual differences in subjective well-being across the adult lifespan. PMID:19140654

  15. Delineation of a spatial working memory profile using a non-verbal eye-tracking paradigm in young children with autism and Williams syndrome.

    PubMed

    Fanning, Peter A J; Hocking, Darren R; Dissanayake, Cheryl; Vivanti, Giacomo

    2017-02-09

    Working memory deficits profoundly inhibit children's ability to learn. While deficits have been identified in disorders such as autism spectrum disorder (ASD) and Williams syndrome (WS), findings are equivocal, and very little is known about the nature of these deficits early in development. A major barrier to advances in this area is the availability of tasks suitable for young children with neurodevelopmental disorders who experience difficulties with following verbal instructions or who are distressed by formal testing demands. To address these issues, a novel eye-tracking paradigm was designed based on an adaptation of the classic A not B paradigm in order to examine the early foundations of spatial working memory capabilities in 26 developmentally delayed preschool children with ASD, 18 age- and IQ-matched children with WS, and 19 age-matched typically-developing (TD) children. The results revealed evidence that foundational spatial working memory performance in ASD and WS was comparable with that of TD children. Performance was associated with intellectual ability in the ASD and TD groups, but not in the WS group. Performance was not associated with adaptive behavior in any group. These findings are discussed in the context of previous research that has been largely limited to older and substantially less developmentally delayed children with these neurodevelopmental disorders.

  16. Fatty acid profile, carcass and meat quality traits of young Nellore bulls fed crude glycerin replacing energy sources in the concentrate.

    PubMed

    Lage, J F; Berchielli, T T; San Vito, E; Silva, R A; Ribeiro, A F; Reis, R A; Dallantonia, E E; Simonetti, L R; Delevatti, L M; Machado, M

    2014-03-01

    Carcass and meat quality traits of 60 Nellore young bulls fed diets without crude glycerin (CG); with CG replacing corn (CGc; 10% of dry matter - DM) in the concentrate; and with CG replacing soybean hull (CGsh; 10% of DM) in the concentrate were evaluated. Diets were evaluated at two concentrate levels (CLs). The CL did not affect cold carcass weight (CCW; P=0.6074), cold carcass dressing (CCD; P=0.9636), rib fat thickness (RFT; P=0.8696) and longissimus muscle area (LMA; P=0.7524). Animals fed diets with CGc or CGsh showed meat with greater deposition of monounsaturated fatty acid (MUFA; P=0.0022) and CLA (18:2 cis-9, trans-11) contents (P=0.0001) than animals fed diets without CG. The inclusion of 10% of CG in diets CGc or CGsh does not affect the carcass and meat quality traits; however, it increases the MUFA and CLA contents in beef, although these changes are very small in nutritional terms. © 2013.

  17. Adolescent and young adult (AYA) lymphoma survivors report lower health-related quality of life compared to a normative population: results from the PROFILES registry.

    PubMed

    Husson, Olga; Prins, Judith B; Kaal, Suzanne E J; Oerlemans, Simone; Stevens, Wendy B; Zebrack, Bradley; van der Graaf, Winette T A; van de Poll-Franse, Lonneke V

    2017-02-01

    Trying to simultaneously achieve developmental milestones and cope with a life-threatening disease may place adolescents and young adults (AYAs) at risk for impaired health-related quality of life (HRQoL) later in life. The aim of this study was to examine differences in HRQoL between AYA lymphoma survivors and a normative population and to determine sociodemographic, clinical and long-term symptom-related factors associated with HRQoL. This study was part of a longitudinal, population-based survey among lymphoma survivors diagnosed between 1999 and 2012. The AYA survivor sample (18-39 years at time diagnosis) was compared to a sex- and age-matched normative population on HRQoL (EORTC-QLQ-C30) and psychological distress (HADS). Multiple linear regression analyses were conducted to determine factors associated with HRQoL among survivors. One hundred and ninety-eight AYA lymphoma survivors (58%) responded to the study invitation. Compared to an age- and sex-matched normative population (N = 380), significantly and clinically relevant poorer HRQoL was observed for AYA lymphoma survivors in seven specific domains of HRQoL: physical, role, cognitive, emotional, social functioning, fatigue and financial difficulties (all p < 0.05). In addition, AYA lymphoma survivors less often had a spouse/partner and more often had a lower educational level compared to the normative population. Linear regression analyses showed that being unemployed, female gender, having one or more comorbid conditions, high levels of fatigue and psychological distress were most strongly associated with HRQoL. These findings identify specific domains of life in which cancer has a significant and long-term impact for AYA lymphoma survivors. Future investigations are needed to identify and test administrations and timing of psychosocial support interventions having potential to reduce long-term late effects in specific HRQoL domains and promote function and adaptability after cancer treatment.

  18. Gastric Cancer in Young Patients

    PubMed Central

    Dhobi, Manzoor A.; Wani, Khursheed Alam; Parray, Fazl Qadir; Wani, Rouf A.; Peer, G. Q.; Abdullah, Safiya; Wani, Imtiyaz A.; Wani, Muneer A.; Shah, Mubashir A.; Thakur, Natasha

    2013-01-01

    Aim. The aim of this study was to see the clinical, pathological, and demographic profile of young patients with stomach carcinoma besides association with p53. Patients and Methods. Prospective study of young patients with stomach carcinoma from January 2005 to December 2009. A total of 50 patients with age less than 40 years were studied. Results. Male female ratio was 1 : 1.08 in young patients and 2.5 : 1 in older patients. A positive family history of stomach cancer in the first degree relatives was present in 10% of young patients. Resection was possible only in 50% young patients. 26% young patients underwent only palliative gastrojejunostomy. The most common operation was lower partial gastrectomy in 68%. Amongst the intraoperative findings peritoneal metastasis was seen in 17.4% in young patients. 50% young patients presented in stage IV as per AJCC classification (P value .004; sig.). None of the patients presented as stage 1 disease in young group. Conclusion. Early detection of stomach carcinoma is very important in all patients but in young patients it is of paramount importance. PMID:24381753

  19. Raising the profile of mental health nursing.

    PubMed

    Lomas, Clare

    2016-10-26

    Now an associate professor at Swansea University, Julia Terry was a senior lecturer when she applied for a fellowship with the National Institute for Health and Care Excellence (NICE), and is convinced this was a key factor in her promotion.

  20. ISS Expedition 42 Crew Profiles - Version 01

    NASA Image and Video Library

    2014-11-14

    Narrated program with biographical information about ISS Expedition 42 crewmembers Terry Virts, Samantha Cristoforetti and Anton Shjaplerov. The program covers the crewmember's career including childhood photographs; footage from previous missions; and interview sound bites.

  1. Young Child.

    ERIC Educational Resources Information Center

    DeVoogd, Glenn, Ed.

    This document contains the following papers focusing on contexts and activities in which teachers can use technology to promote learning with young children: (1) "Read, Write and Click: Using Digital Camera Technology in a Language Arts and Literacy K-5 Classroom" (Judith F. Robbins and Jacqueline Bedell); (2) "Technology for the…

  2. Young Murderers.

    ERIC Educational Resources Information Center

    Garbarino, James

    1999-01-01

    Reflects on the moral world of children who have committed acts of lethal violence. Young killers do not see any positive alternatives at the moment of violence. When they kill, they are seeking justice--as they see it. Emphasizes the importance of adults stimulating the development of empathy and spirituality. (SLD)

  3. Young Crater

    NASA Image and Video Library

    2012-11-12

    This image from NASA 2001 Mars Odyssey spacecraft shows a young crater. Dark radial spokes are created by the explosive blast of an impact event. With time, only thick ejecta near the rim of the crater will be visible, and dark spokes will disappear.

  4. Young Murderers.

    ERIC Educational Resources Information Center

    Garbarino, James

    1999-01-01

    Reflects on the moral world of children who have committed acts of lethal violence. Young killers do not see any positive alternatives at the moment of violence. When they kill, they are seeking justice--as they see it. Emphasizes the importance of adults stimulating the development of empathy and spirituality. (SLD)

  5. Brief Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children

    ERIC Educational Resources Information Center

    Wiggins, Lisa D.; Robins, Diana L.; Bakeman, Roger; Adamson, Lauren B.

    2009-01-01

    The purpose of this study was to explore the sensory profile of young children with ASD compared to young children with other developmental delays (DD) at first ASD assessment. Results found that young children with ASD had more tactile and taste/smell sensitivities and difficulties with auditory filtering than young children with other DD.…

  6. Brief Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children

    ERIC Educational Resources Information Center

    Wiggins, Lisa D.; Robins, Diana L.; Bakeman, Roger; Adamson, Lauren B.

    2009-01-01

    The purpose of this study was to explore the sensory profile of young children with ASD compared to young children with other developmental delays (DD) at first ASD assessment. Results found that young children with ASD had more tactile and taste/smell sensitivities and difficulties with auditory filtering than young children with other DD.…

  7. Lipid Profile

    MedlinePlus

    ... AACC products and services. Advertising & Sponsorship: Policy | Opportunities Lipid Profile Share this page: Was this page helpful? Also ... as: Lipid Panel; Coronary Risk Panel Formal name: Lipid Profile Related tests: Cholesterol ; HDL Cholesterol ; LDL Cholesterol ; Triglycerides ; ...

  8. State Profiles.

    ERIC Educational Resources Information Center

    State-Federal Information Clearinghouse for Exceptional Children, Reston, VA.

    State-by-state public policy profiles are provided by the Council for Exceptional Children's State-Federal Information Clearinghouse. These profiles summarize the present legal base for the delivery of educational services to handicapped children in the United States. Included in each profile is information from various avenues used to establish…

  9. Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis

    PubMed Central

    Yang, Wenjia; Cai, Xiaoling; Han, Xueyao; Ji, Linong

    2016-01-01

    Objective The prevalence of type 2 diabetes is increasing rapidly in the young population. The clinical characteristics and risk factors for young type 2 diabetes patients with atherosclerosis are not fully explicated. The aim of the present study was to investigate various clinical and biochemical characteristics of young type 2 diabetic patients with atherosclerosis. Design and Methods This was a cross-sectional study. The study involved 2199 hospitalized patients with type 2 diabetes. The young patients were classified into the atherosclerotic group or the non-atherosclerotic group, and we also enrolled an older group with peripheral atherosclerosis disease and an age of at least 45 years. Comparisons were made between the different groups to investigate the cardiovascular and metabolic risk profiles of young type 2 diabetes patients with atherosclerosis. We also used logistic regression models to assess the atherosclerosis risk factors for young patients. Results Compared to older type 2 diabetes patients with atherosclerosis, young patients with atherosclerosis had more deleterious profiles of weight and hyperlipidemia. Only age and diabetes duration were found to be significant independent risk factors for atherosclerosis in young patients. The ratio of the presence of atherosclerosis in the lower extremity arteries alone was significantly higher in young patients than older patients (26.4% vs. 14.0%, P = 0.000). Conclusion Young type 2 diabetes patients with atherosclerosis have more adverse cardiovascular risk profiles and inadequate control of these risk factors. Lower extremity examination is of high importance in young patients. PMID:27391819

  10. A Proteomic Profiling Approach to Reveal a Novel Role of Brassica napus Drought 22 kD/Water-Soluble Chlorophyll-Binding Protein in Young Leaves during Nitrogen Remobilization Induced by Stressful Conditions1

    PubMed Central

    Desclos, Marie; Dubousset, Lucie; Etienne, Philippe; Le Caherec, Françoise; Satoh, Hiroyushi; Bonnefoy, Josette; Ourry, Alain; Avice, Jean-Christophe

    2008-01-01

    Despite its water-soluble chlorophyll-binding protein (WSCP) function, the putative trypsin inhibitor (TI) activity of the Brassica napus drought 22 kD (BnD22) protein and its physiological function in young leaves during leaf nitrogen (N) remobilization promoted by stressful conditions remains an enigma. Therefore, our objectives were to determine (1) if BnD22 is related to the 19-kD TI previously detected in B. napus young leaves, and (2) if the levels of BnD22 transcripts, BnD22 protein, and TI activity in young leaves are associated with plant responses to stress conditions (N starvation and methyl jasmonate [MeJA] treatments) that are able to modulate leaf senescence. Compared to control, N starvation delayed initiation of senescence and induced 19-kD TI activity in the young leaves. After 3 d with MeJA, the 19-kD TI activity was 7-fold higher than the control. Using two-dimensional electrophoresis gel, TI activity, and electrospray ionization liquid chromatography tandem mass spectrometry analysis, it was demonstrated that two 19-kD proteins with isoelectric points 5.0 and 5.1 harboring TI activity correspond to BnD22 perfectly. BnD22 gene expression, TI activities, and BnD22 protein presented similar patterns. Using polyclonal anti-WSCP antibodies of Brassica oleracea, six polypeptides separated by two-dimensional electrophoresis were detected in young leaves treated with MeJA. Electrospray ionization liquid chromatography tandem mass spectrometry analysis of six polypeptides confirms their homologies with WSCP. Results suggest that BnD22 possesses dual functions (WSCP and TI) that lead to the protection of younger tissues from adverse conditions by maintaining metabolism (protein integrity and photosynthesis). By sustaining sink growth of stressed plants, BnD22 may contribute to a better utilization of recycling N from sources, a physiological trait that improves N-use efficiency. PMID:18552235

  11. A proteomic profiling approach to reveal a novel role of Brassica napus drought 22 kD/water-soluble chlorophyll-binding protein in young leaves during nitrogen remobilization induced by stressful conditions.

    PubMed

    Desclos, Marie; Dubousset, Lucie; Etienne, Philippe; Le Caherec, Françoise; Satoh, Hiroyushi; Bonnefoy, Josette; Ourry, Alain; Avice, Jean-Christophe

    2008-08-01

    Despite its water-soluble chlorophyll-binding protein (WSCP) function, the putative trypsin inhibitor (TI) activity of the Brassica napus drought 22 kD (BnD22) protein and its physiological function in young leaves during leaf nitrogen (N) remobilization promoted by stressful conditions remains an enigma. Therefore, our objectives were to determine (1) if BnD22 is related to the 19-kD TI previously detected in B. napus young leaves, and (2) if the levels of BnD22 transcripts, BnD22 protein, and TI activity in young leaves are associated with plant responses to stress conditions (N starvation and methyl jasmonate [MeJA] treatments) that are able to modulate leaf senescence. Compared to control, N starvation delayed initiation of senescence and induced 19-kD TI activity in the young leaves. After 3 d with MeJA, the 19-kD TI activity was 7-fold higher than the control. Using two-dimensional electrophoresis gel, TI activity, and electrospray ionization liquid chromatography tandem mass spectrometry analysis, it was demonstrated that two 19-kD proteins with isoelectric points 5.0 and 5.1 harboring TI activity correspond to BnD22 perfectly. BnD22 gene expression, TI activities, and BnD22 protein presented similar patterns. Using polyclonal anti-WSCP antibodies of Brassica oleracea, six polypeptides separated by two-dimensional electrophoresis were detected in young leaves treated with MeJA. Electrospray ionization liquid chromatography tandem mass spectrometry analysis of six polypeptides confirms their homologies with WSCP. Results suggest that BnD22 possesses dual functions (WSCP and TI) that lead to the protection of younger tissues from adverse conditions by maintaining metabolism (protein integrity and photosynthesis). By sustaining sink growth of stressed plants, BnD22 may contribute to a better utilization of recycling N from sources, a physiological trait that improves N-use efficiency.

  12. Young Children's Explorations: Young Children's Research?

    ERIC Educational Resources Information Center

    Murray, Jane

    2012-01-01

    "Exploration" is recognised as research behaviour; anecdotally, as an early years' teacher, I witnessed many young children exploring. However, young children's self-initiated explorations are rarely regarded as research by adult researchers and policy-makers. The exclusion of young children's autonomous explorations from recognition as…

  13. Young Adult Literature for Young Adult Males.

    ERIC Educational Resources Information Center

    Gill, Sam D.

    1999-01-01

    Argues that young adult literature can play a significant role in the emotional and mental health of an adolescent as well as help young males become more literate. Offers a 19-item annotated list of young adult novels with male protagonists, sorted by themes: nature and adventure stories, sports stories, genre stories, historical stories, and…

  14. Transcriptome profile analysis of young floral buds of fertile and sterile plants from the self-pollinated offspring of the hybrid between novel restorer line NR1 and Nsa CMS line in Brassica napus

    PubMed Central

    2013-01-01

    Background The fertile and sterile plants were derived from the self-pollinated offspring of the F1 hybrid between the novel restorer line NR1 and the Nsa CMS line in Brassica napus. To elucidate gene expression and regulation caused by the A and C subgenomes of B. napus, as well as the alien chromosome and cytoplasm from Sinapis arvensis during the development of young floral buds, we performed a genome-wide high-throughput transcriptomic sequencing for young floral buds of sterile and fertile plants. Results In this study, equal amounts of total RNAs taken from young floral buds of sterile and fertile plants were sequenced using the Illumina/Solexa platform. After filtered out low quality data, a total of 2,760,574 and 2,714,441 clean tags were remained in the two libraries, from which 242,163 (Ste) and 253,507 (Fer) distinct tags were obtained. All distinct sequencing tags were annotated using all possible CATG+17-nt sequences of the genome and transcriptome of Brassica rapa and those of Brassica oleracea as the reference sequences, respectively. In total, 3231 genes of B. rapa and 3371 genes of B. oleracea were detected with significant differential expression levels. GO and pathway-based analyses were performed to determine and further to understand the biological functions of those differentially expressed genes (DEGs). In addition, there were 1089 specially expressed unknown tags in Fer, which were neither mapped to B. oleracea nor to B. rapa, and these unique tags were presumed to arise basically from the added alien chromosome of S. arvensis. Fifteen genes were randomly selected and their expression levels were confirmed by quantitative RT-PCR, and fourteen of them showed consistent expression patterns with the digital gene expression (DGE) data. Conclusions A number of genes were differentially expressed between the young floral buds of sterile and fertile plants. Some of these genes may be candidates for future research on CMS in Nsa line, fertility

  15. Transcriptome profile analysis of young floral buds of fertile and sterile plants from the self-pollinated offspring of the hybrid between novel restorer line NR1 and Nsa CMS line in Brassica napus.

    PubMed

    Yan, Xiaohong; Dong, Caihua; Yu, Jingyin; Liu, Wanghui; Jiang, Chenghong; Liu, Jia; Hu, Qiong; Fang, Xiaoping; Wei, Wenhui

    2013-01-16

    The fertile and sterile plants were derived from the self-pollinated offspring of the F1 hybrid between the novel restorer line NR1 and the Nsa CMS line in Brassica napus. To elucidate gene expression and regulation caused by the A and C subgenomes of B. napus, as well as the alien chromosome and cytoplasm from Sinapis arvensis during the development of young floral buds, we performed a genome-wide high-throughput transcriptomic sequencing for young floral buds of sterile and fertile plants. In this study, equal amounts of total RNAs taken from young floral buds of sterile and fertile plants were sequenced using the Illumina/Solexa platform. After filtered out low quality data, a total of 2,760,574 and 2,714,441 clean tags were remained in the two libraries, from which 242,163 (Ste) and 253,507 (Fer) distinct tags were obtained. All distinct sequencing tags were annotated using all possible CATG+17-nt sequences of the genome and transcriptome of Brassica rapa and those of Brassica oleracea as the reference sequences, respectively. In total, 3231 genes of B. rapa and 3371 genes of B. oleracea were detected with significant differential expression levels. GO and pathway-based analyses were performed to determine and further to understand the biological functions of those differentially expressed genes (DEGs). In addition, there were 1089 specially expressed unknown tags in Fer, which were neither mapped to B. oleracea nor to B. rapa, and these unique tags were presumed to arise basically from the added alien chromosome of S. arvensis. Fifteen genes were randomly selected and their expression levels were confirmed by quantitative RT-PCR, and fourteen of them showed consistent expression patterns with the digital gene expression (DGE) data. A number of genes were differentially expressed between the young floral buds of sterile and fertile plants. Some of these genes may be candidates for future research on CMS in Nsa line, fertility restoration and improved agronomic

  16. Biophysical Profile

    MedlinePlus

    ... is Rh positive Worrisome results from other prenatal tests Your health care provider might also recommend a biophysical profile if ... the test and at regular intervals during the test. Your health care provider or a member of your health care ...

  17. Leadership Profiles.

    ERIC Educational Resources Information Center

    Teach, Beverly; And Others

    1994-01-01

    Presents profiles of two leaders in the field of educational media and technology: Carolyn Guss and Mendel Sherman, both retired professors from Indiana University's program in Information Systems Technology. (KRN)

  18. Leadership Profiles.

    ERIC Educational Resources Information Center

    Morgan, Robert M.; And Others

    1992-01-01

    Presents profiles of three leaders in the field of educational media and technology: Robert Mills Gagne, Florida State University; Robert Heinich, Indiana University; and Charles Francis Schuller, University of Georgia. (SLW)

  19. Leadership Profiles.

    ERIC Educational Resources Information Center

    Morgan, Robert M.; And Others

    1992-01-01

    Presents profiles of three leaders in the field of educational media and technology: Robert Mills Gagne, Florida State University; Robert Heinich, Indiana University; and Charles Francis Schuller, University of Georgia. (SLW)

  20. Leadership Profiles.

    ERIC Educational Resources Information Center

    Teach, Beverly; And Others

    1994-01-01

    Presents profiles of two leaders in the field of educational media and technology: Carolyn Guss and Mendel Sherman, both retired professors from Indiana University's program in Information Systems Technology. (KRN)

  1. "You're too young for this": adolescent and young adults' perspectives on cancer survivorship.

    PubMed

    Kent, Erin E; Parry, Carla; Montoya, Michael J; Sender, Leonard S; Morris, Rebecca A; Anton-Culver, Hoda

    2012-01-01

    Adolescent and young adult cancer survivors face unique challenges not systematically addressed by cancer clinicians. Four focus groups and two individual interviews were conducted with 19 survivors to profile experiences and identify key concerns for future interventions. The resultant themes reflect cancer care continuum challenges (such as delays in diagnosis, problems with adherence), psychosocial concerns (such as infertility and reproductive concerns, changing social relationships, financial burden), and the paradox of being diagnosed with cancer as a young adult. Future intervention development for adolescent and young adult survivors should involve patient voices at each stage of the research process.

  2. “You’re too young for this”: Adolescent and Young Adults’ Perspectives on Cancer Survivorship

    PubMed Central

    KENT, ERIN E.; PARRY, CARLA; MONTOYA, MICHAEL J.; SENDER, LEONARD S.; MORRIS, REBECCA A.; ANTON-CULVER, HODA

    2015-01-01

    Adolescent and young adult cancer survivors face unique challenges not systematically addressed by cancer clinicians. Four focus groups and two individual interviews were conducted with 19 survivors to profile experiences and identify key concerns for future interventions. The resultant themes reflect cancer care continuum challenges (such as delays in diagnosis, problems with adherence), psychosocial concerns (such as infertility and reproductive concerns, changing social relationships, financial burden), and the paradox of being diagnosed with cancer as a young adult. Future intervention development for adolescent and young adult survivors should involve patient voices at each stage of the research process. PMID:22416959

  3. ISS Expedition 42 Crew Profile, Version 2

    NASA Image and Video Library

    2014-11-26

    Narrated production with biographical information about ISS Expedition 42 crewmembers Barry "Butch" Wilmore, Alexander Samokutyaev, Elena Serova, Terry Virts, Anton Shkaplerov and Samantha Cristoforetti. The program covers the crewmember's career including childhood photographs, previous space missions and interview sound bites with the crewmembers.

  4. A Comparison of Support for Two Groups of Young Adults with Mild Intellectual Disability

    ERIC Educational Resources Information Center

    Soenen, Sarah; van Berckelaer-Onnes, Ina; Scholte, Evert

    2016-01-01

    Young adults with mild to borderline intellectual disability (MBID) have varying profiles of cognitive, adaptive and behavioural functioning. There is also variability in their educational and therapeutic needs. This study compares recommended and actual provision of support for two groups of young adults with MBID and looks at young adults'…

  5. A Comparison of Support for Two Groups of Young Adults with Mild Intellectual Disability

    ERIC Educational Resources Information Center

    Soenen, Sarah; van Berckelaer-Onnes, Ina; Scholte, Evert

    2016-01-01

    Young adults with mild to borderline intellectual disability (MBID) have varying profiles of cognitive, adaptive and behavioural functioning. There is also variability in their educational and therapeutic needs. This study compares recommended and actual provision of support for two groups of young adults with MBID and looks at young adults'…

  6. Leadership Profiles.

    ERIC Educational Resources Information Center

    Orey, Michael; Moore, David M.; Reeves, Thomas

    2003-01-01

    Contains the following two leadership profiles of individuals who have made significant contributions to the field of instructional technology: "Francis M. Dwyer: Visual Researcher Extraordinaire" (David M. Moore); and "Tribute to John G. Hedberg: Professor of Education, University of Wollongong" (Thomas Reeves). (MES)

  7. Ranking Profiles

    ERIC Educational Resources Information Center

    Van Der Werf, Martin

    2007-01-01

    This article presents the "U.S. News" ranking profiles of four colleges, namely: (1) Smith College; (2) Washington University in St. Louis; (3) Colorado State University at Fort Collins; and (4) Whitman College. Smith College was in the top 10 of the nation's liberal-arts colleges, or just outside it, almost since the "U.S.…

  8. Polycystic ovary syndrome and obesity do not affect vascular parameters related to early atherosclerosis in young women without glucose metabolism disturbances, arterial hypertension and severe abnormalities of lipid profile.

    PubMed

    Barcellos, Cristiano Roberto Grimaldi; Lage, Silvia Helena Gelás; Rocha, Michelle Patrocínio; Hayashida, Sylvia Asaka Yamashita; Baracat, Edmund Chade; Romano, Angela; Brito, Vinicius Nahime; Marcondes, José Antonio Miguel

    2013-04-01

    The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on vascular parameters related to early atherosclerosis (VP-EA) [brachial flow-mediated dilation (FMD), carotid intima-media thickness (CIMT) and carotid arterial compliance (CAC)] in women with minor cardiovascular risk factors (CVRFs). Twenty-five young women with PCOS and 23 eumenorrheic women matched for body mass index (BMI) were studied. The women were subdivided according to BMI and PCOS status, and comparisons were done between PCOS and Control group, regardless of BMI, and between Obese and Lean group, regardless of the presence of PCOS. Insulin resistance was higher in PCOS-group than in control-group and in obese-group than in lean-group. The median of all VP-EA evaluated were similar between PCOS-group and Control-group [FMD: 6.6 versus 8.4% (p = NS); CIMT: 48.0 versus 47.0 mm.10-2 (p = NS); CAC: 6.2 versus 5.6N-1.m4.10-10 (p = NS)] and between obese-group and lean-group [FMD: 7.8 versus 6.6% (p = NS); CIMT: 48.0 versus 47.0 mm.10-2 (p = NS); CAC: 5.7 versus 6.3N-1.m4.10-10 (p = NS)]. These results suggest that PCOS and obesity do not affect VP-EA in women with minor CVRFs.

  9. ADHD in Young Children

    MedlinePlus

    ... Error processing SSI file Error processing SSI file ADHD in Young Children Use recommended treatment first Language: ... The recommended first treatment for young children with ADHD is underused. The American Academy of Pediatrics recommends ...

  10. Young Adult Services Manual.

    ERIC Educational Resources Information Center

    Boegen, Anne, Ed.

    Designed to offer guidelines, ideas and help to those who provide library service to young adults, this manual includes information about the provision of young adult (YA) services in six sections. The first section, which addresses planning and administration, includes a definition of a young adult and a checklist for determining community needs…

  11. Young Adult Library Services.

    ERIC Educational Resources Information Center

    The Bookmark, 1985

    1985-01-01

    Eight articles in this Spring 1985 issue of The Bookmark focus on young adult library services. In addition to these thematic articles, an introduction and three reports are presented. The issue contains: (1) "In Perspective" (E. J. Josey); (2) "Young Adult Literature in the 1980's--Awesome!" (Ellin Chu); (3) "Young Adult…

  12. Marriage Matters But How Much? Marital Centrality Among Young Adults.

    PubMed

    Willoughby, Brian J; Hall, Scott S; Goff, Saige

    2015-01-01

    Marriage, once a gateway to adulthood, is no longer as widely considered a requirement for achieving adult status. With declining marriage rates and delayed marital transitions, some have wondered whether current young adults have rejected the traditional notion of marriage. Utilizing a sample of 571 young adults, the present study explored how marital centrality (the expected importance to be placed on the marital role relative to other adult roles) functioned as a unique and previously unexplored marital belief among young adults. Results suggested that marriage remains an important role for many young adults. On average, young adults expected that marriage would be more important to their life than parenting, careers, or leisure activities. Marital centrality profiles were found to significantly differ based on both gender and religiosity. Marital centrality was also associated with various outcomes including binge-drinking and sexual activity. Specifically, the more central marriage was expected to be, the less young adults engaged in risk-taking or sexual behaviors.

  13. Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey – A Meta-Analysis of Three Independent Studies

    PubMed Central

    Lyytikäinen, Leo-Pekka; Mononen, Nina; Oksala, Niku; Hutri-Kähönen, Nina; Juonala, Markus; Taittonen, Leena; Smith, Erin N.; Schork, Nicholas J.; Chen, Wei; Srinivasan, Sathanur R.; Berenson, Gerald S.; Murray, Sarah S.; Laitinen, Tomi; Jula, Antti; Kettunen, Johannes; Ripatti, Samuli; Laaksonen, Reijo; Viikari, Jorma; Kähönen, Mika; Raitakari, Olli T.; Lehtimäki, Terho

    2012-01-01

    Background Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve already known associations and discovered thirteen new SNPs associating with CAD. We examined whether the genetic profiling of these variants improves prediction of subclinical atherosclerosis – i.e., carotid intima-media thickness (CIMT) and carotid artery elasticity (CAE) – beyond classical risk factors. Subjects and Methods We genotyped 24 variants found in a population of European ancestry and measured CIMT and CAE in 2001 and 2007 from 2,081, and 2,015 subjects (aged 30–45 years in 2007) respectively, participating in the Cardiovascular Risk in Young Finns Study (YFS). The Bogalusa Heart Study (BHS; n = 1179) was used as a replication cohort (mean age of 37.5). For additional replication, a sub-sample of 5 SNPs was genotyped for 1,291 individuals aged 46–76 years participating in the Health 2000 population survey. We tested the impact of genetic risk score (GRS24SNP/CAD) calculated as a weighted (by allelic odds ratios for CAD) sum of CAD risk alleles from the studied 24 variants on CIMT, CAE, the incidence of carotid atherosclerosis and the progression of CIMT and CAE during a 6-year follow-up. Results CIMT or CAE did not significantly associate with GRS24SNP/CAD before or after adjusting for classical CAD risk factors (p>0.05 for all) in YFS or in the BHS. CIMT and CAE associated with only one SNP each in the YFS. The findings were not replicated in the replication cohorts. In the meta-analysis CIMT or CAE did not associate with any of the SNPs. Conclusion Genetic profiling, by using known CAD risk variants, should not improve risk stratification for subclinical atherosclerosis beyond conventional risk factors among healthy young adults. PMID

  14. Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

    PubMed

    Hernesniemi, Jussi A; Seppälä, Ilkka; Lyytikäinen, Leo-Pekka; Mononen, Nina; Oksala, Niku; Hutri-Kähönen, Nina; Juonala, Markus; Taittonen, Leena; Smith, Erin N; Schork, Nicholas J; Chen, Wei; Srinivasan, Sathanur R; Berenson, Gerald S; Murray, Sarah S; Laitinen, Tomi; Jula, Antti; Kettunen, Johannes; Ripatti, Samuli; Laaksonen, Reijo; Viikari, Jorma; Kähönen, Mika; Raitakari, Olli T; Lehtimäki, Terho

    2012-01-01

    Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve already known associations and discovered thirteen new SNPs associating with CAD. We examined whether the genetic profiling of these variants improves prediction of subclinical atherosclerosis--i.e., carotid intima-media thickness (CIMT) and carotid artery elasticity (CAE)--beyond classical risk factors. We genotyped 24 variants found in a population of European ancestry and measured CIMT and CAE in 2001 and 2007 from 2,081, and 2,015 subjects (aged 30-45 years in 2007) respectively, participating in the Cardiovascular Risk in Young Finns Study (YFS). The Bogalusa Heart Study (BHS; n = 1179) was used as a replication cohort (mean age of 37.5). For additional replication, a sub-sample of 5 SNPs was genotyped for 1,291 individuals aged 46-76 years participating in the Health 2000 population survey. We tested the impact of genetic risk score (GRS(24SNP/CAD)) calculated as a weighted (by allelic odds ratios for CAD) sum of CAD risk alleles from the studied 24 variants on CIMT, CAE, the incidence of carotid atherosclerosis and the progression of CIMT and CAE during a 6-year follow-up. CIMT or CAE did not significantly associate with GRS(24SNP/CAD) before or after adjusting for classical CAD risk factors (p>0.05 for all) in YFS or in the BHS. CIMT and CAE associated with only one SNP each in the YFS. The findings were not replicated in the replication cohorts. In the meta-analysis CIMT or CAE did not associate with any of the SNPs. Genetic profiling, by using known CAD risk variants, should not improve risk stratification for subclinical atherosclerosis beyond conventional risk factors among healthy young adults.

  15. MPI Profiling

    SciTech Connect

    Han, D K; Jones, T R

    2005-02-11

    The Message Passing Interface (MPI) is the de facto message-passing standard for massively parallel programs. It is often the case that application performance is a crucial factor, especially for solving grand challenge problems. While there have been many studies on the scalability of applications, there have not been many focusing on the specific types of MPI calls being made and their impact on application performance. Using a profiling tool called mpiP, a large spectrum of parallel scientific applications were surveyed and their performance results analyzed.

  16. Appalachian Children and Their Families. A Statistical Profile.

    ERIC Educational Resources Information Center

    CSR, Inc., Arlington, VA.

    A statistical profile of Appalachia's young children, from birth to 9 years, was compiled from federal and state data sources. The profile provides information important in making immediate and long range plans for improving the status of Appalachian children and their families. An examination of family living conditions suggests that Appalachian…

  17. Clinical and molecular features of young-onset colorectal cancer

    PubMed Central

    Ballester, Veroushka; Rashtak, Shahrooz; Boardman, Lisa

    2016-01-01

    Colorectal cancer (CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression. PMID:26855533

  18. Management of breast cancer in very young women.

    PubMed

    Freedman, Rachel A; Partridge, Ann H

    2013-08-01

    Breast cancer is the leading cause of cancer-related deaths in women age 40 and younger in developed countries, and although generally improving, survival rates for young women with breast cancer remain lower than for older women. Young women are more likely to develop more aggressive subtypes of breast cancer and previous research has suggested that young age is an independent risk factor for disease recurrence and death, and there may be unique biologic features of breast cancer that occurs in young women. Certainly, there are host differences biologically as well as psychosocially that affect the management of breast cancer and survivorship concerns for young women compared to older women. Multi-agent chemotherapy and biologic therapy targeting the tumor similar to the treatment in older women is standard, with careful attention to unique survivorship concerns including genetics, infertility, and psychosocial issues. Select young women will do well with hormone therapy only, although at present, the optimal hormonal therapy for very young women remains unclear. Recent data demonstrating that 10 years of tamoxifen improves outcomes compared to 5 may be particularly beneficial for young women with hormone receptor-positive tumors given the risk benefit profile. Future and ongoing studies focused on breast cancer in young women, addressing both biology as well as psychosocial issues, including supportive care interventions should improve outcomes for young women with breast cancer. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Factors Associated with Young Adults’ Pregnancy Likelihood

    PubMed Central

    Kitsantas, Panagiota; Lindley, Lisa L.; Wu, Huichuan

    2014-01-01

    OBJECTIVES While progress has been made to reduce adolescent pregnancies in the United States, rates of unplanned pregnancy among young adults (18–29 years) remain high. In this study, we assessed factors associated with perceived likelihood of pregnancy (likelihood of getting pregnant/getting partner pregnant in the next year) among sexually experienced young adults who were not trying to get pregnant and had ever used contraceptives. METHODS We conducted a secondary analysis of 660 young adults, 18–29 years old in the United States, from the cross-sectional National Survey of Reproductive and Contraceptive Knowledge. Logistic regression and classification tree analyses were conducted to generate profiles of young adults most likely to report anticipating a pregnancy in the next year. RESULTS Nearly one-third (32%) of young adults indicated they believed they had at least some likelihood of becoming pregnant in the next year. Young adults who believed that avoiding pregnancy was not very important were most likely to report pregnancy likelihood (odds ratio [OR], 5.21; 95% CI, 2.80–9.69), as were young adults for whom avoiding a pregnancy was important but not satisfied with their current contraceptive method (OR, 3.93; 95% CI, 1.67–9.24), attended religious services frequently (OR, 3.0; 95% CI, 1.52–5.94), were uninsured (OR, 2.63; 95% CI, 1.31–5.26), and were likely to have unprotected sex in the next three months (OR, 1.77; 95% CI, 1.04–3.01). DISCUSSION These results may help guide future research and the development of pregnancy prevention interventions targeting sexually experienced young adults. PMID:25782849

  20. [Vulvovaginitis in young girls].

    PubMed

    Olejek, Anita; Kellas-Sleczka, Sylwia; Kozak-Darmas, Iwona; Bilska, Anna; Zamłyński, Jacek; Horak, Stanisław; Nowak, Leszek

    2009-12-01

    Vulvovaginitis is the most common cause of gynecological complaints in young girls. Factors which cause vulvovaginitis include, among other things, low level of sexual hormones (hypoestrogenism), the anatomical proximity of the rectum and delicate vulvar skin and vaginal mucosa. Usually vulvovaginitis in young girls is caused by non-specific factors. The aim of the study was to present the most frequent causes of vulvovaginitis in young girls.

  1. SOFIA Scientist Erick Young

    NASA Image and Video Library

    Erick Young of the Universities Space Research Association, science mission operations director for the Stratospheric Observatory for Infrared Astronomy (SOFIA), comments on the astronomical scienc...

  2. 14 and Younger: The Sexual Behavior of Young Adolescents.

    ERIC Educational Resources Information Center

    Albert, Bill, Ed.; Brown, Sarah, Ed.; Flanigan, Christine M., Ed.

    This collection of papers on early adolescent sexual behavior includes seven papers in two parts. Part 1, "Papers from Nationally Representative Data Sets," includes (1) "Dating and Sexual Experiences among Middle School Youth: Analyses of the NLSY97" (Elizabeth Terry-Humen and Jennifer Manlove); "(2) "Dating Behavior…

  3. Young Worker Education

    ERIC Educational Resources Information Center

    Murray, Len

    1976-01-01

    Young people who leave school must have access to education to help them in their working life and in their life in the community. Young worker education is the link between school and the life-long process of education. (ABM)

  4. Evolution for Young Victorians

    ERIC Educational Resources Information Center

    Lightman, Bernard

    2012-01-01

    Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's "Origin of Species." Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented…

  5. Young, Female and Black.

    ERIC Educational Resources Information Center

    Mirza, Heidi Safia

    This book follows the experiences of a group of young African Caribbean British women as they leave school to enter the world of work, in an attempt to understand processes of inequality. Study methodology included a longitudinal survey approach and a school-based ethnography. The study population consisted of 62 young women aged 15 to 19 years…

  6. Nutrition and Young Children.

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.; And Others

    1978-01-01

    The special issue of the journal contains 12 articles on nutrition and young children. The following titles and authors are included: "Overview--Nutritional Needs of Young Children" (M. Scialabba); "Nurturance--Mutually Created--Mother and Child" (M. McFarland); "Feeding the Special Needs Child" (E. Croup); "Maternal and Neonatal Nutrition--Long…

  7. Nutrition and Young Children.

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.; And Others

    1978-01-01

    The special issue of the journal contains 12 articles on nutrition and young children. The following titles and authors are included: "Overview--Nutritional Needs of Young Children" (M. Scialabba); "Nurturance--Mutually Created--Mother and Child" (M. McFarland); "Feeding the Special Needs Child" (E. Croup); "Maternal and Neonatal Nutrition--Long…

  8. Concerts for Young Children

    ERIC Educational Resources Information Center

    Suthers, Louie

    2008-01-01

    Concerts designed to introduce young children to music and live performance are staged by a variety of organisations and ensembles across Australia. Shows featuring a wide range of performers are advertised for young children. Such concerts include Babies' Proms, Family Concerts by symphony orchestras, Play School Concerts, performances by…

  9. Evolution for Young Victorians

    ERIC Educational Resources Information Center

    Lightman, Bernard

    2012-01-01

    Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's "Origin of Species." Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented…

  10. Young People and Risk

    ERIC Educational Resources Information Center

    Trotman, Dave; Martyn, Madeline; Tucker, Stanley

    2012-01-01

    This paper reports the findings of a small-scale qualitative inquiry into risk in the lives of children and young people. Conducted over a 12-month period in Birmingham and the Black Country in the United Kingdom, the study sought to elicit perceptions of risk from the perspective of children and young people in primary and secondary school…

  11. The Paradoxical Young Person

    ERIC Educational Resources Information Center

    Vishnevskii, Iu. R.; Shapko, V. T.

    2007-01-01

    The social transformations in Russian society in the past two decades have made relevant the problem of paradoxality, including its application to young people. The results of many years of sociological studies by the authors investigating the social problems of young people completely confirm Toshchenko's conclusion that "paradoxality of…

  12. Concerts for Young Children

    ERIC Educational Resources Information Center

    Suthers, Louie

    2008-01-01

    Concerts designed to introduce young children to music and live performance are staged by a variety of organisations and ensembles across Australia. Shows featuring a wide range of performers are advertised for young children. Such concerts include Babies' Proms, Family Concerts by symphony orchestras, Play School Concerts, performances by…

  13. Hypertension in young adults.

    PubMed

    De Venecia, Toni; Lu, Marvin; Figueredo, Vincent M

    2016-01-01

    Hypertension remains a major societal problem affecting 76 million, or approximately one third, of US adults. While more prevalent in the older population, an increasing incidence in the younger population, including athletes, is being observed. Active individuals, like the young and athletes, are viewed as free of diseases such as hypertension. However, the increased prevalence of traditional risk factors in the young, including obesity, diabetes mellitus, and renal disease, increase the risk of developing hypertension in younger adults. Psychosocial factors may also be contributing factors to the increasing incidence of hypertension in the younger population. Increased left ventricular wall thickness and mass are increasingly found in young adults on routine echocardiograms and predict future cardiovascular events. This increasing incidence of hypertension in the young calls for early surveillance and prompt treatment to prevent future cardiac events. In this review we present the current epidemiological data, potential mechanisms, clinical implications, and treatment of hypertension in young patients and athletes.

  14. Young Adult Smoking Behavior

    PubMed Central

    Ling, Pamela M.; Neilands, Torsten B.; Glantz, Stanton A.

    2009-01-01

    Background Young adults have the highest smoking rate of any age group in the U.S., and new strategies to decrease young adult smoking are needed. The objective of the current study was to identify psychographic and demographic factors associated with current smoking and quitting behaviors among young adults. Methods Attitudes, social groups, and self-descriptors, including supporting action against the tobacco industry, advertising receptivity, depression, alcohol use, and other factors associated with smoking were tested for associations with smoking behaviors in a 2005 cross-sectional survey of 1528 young adults (aged 18–25 years) from a web-enabled panel. Analyses were conducted in 2007. Results Being older was associated with current smoking, whereas having some higher education and being African American or Hispanic were negatively associated with smoking. Supporting action against the tobacco industry was negatively associated with smoking (AOR=0.34 [95% CI=0.22, 0.52]). Perceived usefulness of smoking, exposure to smokers, increased perceived smoking prevalence, receptivity to tobacco advertising, binge drinking, and exposure to tobacco advertising in bars and clubs were associated with smoking. Supporting action against the tobacco industry was associated with intentions to quit smoking (AOR= 4.43 [95% CI=2.18, 8.60]). Conclusions Young adults are vulnerable to tobacco-industry advertising. Media campaigns that denormalize the tobacco industry and appeal to young adults appear to be a powerful intervention to decrease young adult smoking. PMID:19269128

  15. Language comprehension profiles of young adolescents with fragile X syndrome.

    PubMed

    Oakes, Ashley; Kover, Sara T; Abbeduto, Leonard

    2013-11-01

    In this study, the authors sought to characterize the language phenotype of fragile X syndrome (FXS), focusing on the extent of impairment in receptive syntax, within-syndrome variability in those impairments in relation to gender, and the syndrome specificity of those impairments. The Test for Reception of Grammar, Version 2 ( Bishop, 2003), was used to examine the overall receptive syntactic skills of adolescents with FXS ( n = 35; 30 males, 5 females), adolescents with Down syndrome (DS; n = 28; 18 males, 10 females), and younger typically developing (TD) children ( n = 23; 14 males, 9 females) matched on nonverbal cognition. Performance on specific grammatical constructions and error types was examined for a subset of matched participants. Participants with FXS had overall receptive syntax scores that were lower than those of the TD participants but higher than those of the participants with DS; however, there was no difference in performance between the FXS and DS groups when females were excluded. Grammatical constructions that were especially difficult for participants with FXS and those with DS were identified, especially relative clause constructions and reversible constructions requiring attention to word order encoded by syntactic features. The current findings have implications for understanding the nature of the language learning difficulties of individuals with FXS and for language interventions.

  16. Hormonal profile impact on female sexual function in young women

    NASA Astrophysics Data System (ADS)

    Stoian, Dana; Craciunescu, Mihalea; Craina, Marius; Pater, Liana; Pater, Flavius

    2014-12-01

    Female sexual function is dependent, in physiological milieu upon hormonal impulses: estradiol, testosterone, cortisol, progesterone, prolactin and TSH. Out study tries to appreciate the impact of testosterone, estradiol and prolactin, the major hormones involved in the sexual response, on the normal sexual function. This parameter is approximated by the value of the total FSFI score, a validated international structured interview.

  17. Young "Science Ambassadors" Raise the Profile of Science

    ERIC Educational Resources Information Center

    Ridley, Katie

    2014-01-01

    Katie Ridley, science coordinator at St. Gregory's Catholic Primary School, Liverpool, UK, states that the inspiration for "science ambassadors" came after embarking on the Primary Science Quality Mark programme at their school. Ridley realized that science was just not recognised as such by the children, they talked about scientific…

  18. Young "Science Ambassadors" Raise the Profile of Science

    ERIC Educational Resources Information Center

    Ridley, Katie

    2014-01-01

    Katie Ridley, science coordinator at St. Gregory's Catholic Primary School, Liverpool, UK, states that the inspiration for "science ambassadors" came after embarking on the Primary Science Quality Mark programme at their school. Ridley realized that science was just not recognised as such by the children, they talked about scientific…

  19. Profiling and Racial Profiling: An Interactive Exercise

    ERIC Educational Resources Information Center

    Semple, Philip

    2013-01-01

    Racial Profiling has been recognized as a serious problem that affects many segments of our society and is especially notable in law enforcement. Governments and police services have pronounced that racial profiling is not acceptable and will not be tolerated. They have gone to great lengths in trying to eradicate racial profiling through…

  20. Formation of young massive clusters from turbulent molecular clouds

    NASA Astrophysics Data System (ADS)

    Fujii, Michiko S.

    2015-08-01

    Young massive clusters are as young as open clusters but more massive and compact compared with typical open clusters. The formation process of young massive clusters is still unclear, and it is an open question whether the formation process is the same for typical open clusters or not. We perform a series of N-body simulations starting from initial conditions constructed from the results of hydrodynamical simulations of turbulent molecular clouds. In our simulations, both open clusters and young massive clusters form when we assume a density-dependent star-formation efficiency. We find that a local star-formation efficiency higher than 50% is necessary for the formation of young massive clusters, but open clusters form from less dense regions with a local star formation efficiency of < 50%. We confirm that the young massive clusters formed in our simulations have mass, size, and density profile similar to those of observed young massive clusters such as NGC 3603 and Trumpler 14. We also find that these simulated clusters evolve via hierarchical mergers of sub-clusters within a few mega years, as is suggested by recent simulations and observations. Although we do not assume initial mass segregation, we observe that the simulated massive clusters show a shallower slope of the mass function (Γ ˜ -1) in the cluster center compared to that of the entire cluster (Γ ˜ -1.3). These values are consistent with those of some young massive clusters in the Milky Way such as Westerlund 1 and Arches.

  1. Demographic differences and food patterns associated with metabolic syndrome in young adults

    USDA-ARS?s Scientific Manuscript database

    Little is known about risk factors for metabolic syndrome (MS) in young adults. Intake was collected on 1,012 young adults (20-38 years) (61% female; 26% black) using a food-frequency questionnaire. Demographics, anthropometrics, blood pressure, insulin sensitivity, and lipid profiles were quantifi...

  2. Map and Track: State Initiatives for Young Children and Families. 1998 Edition.

    ERIC Educational Resources Information Center

    Knitzer, Jane; Page, Stephen

    This report profiles state efforts to develop comprehensive programs and policies for young children and families, presents indicators of child and family well-being, and describes state investments in young children and families. Chapter 1, "Overview of Findings and Implications," identifies the research questions, describes data collection…

  3. Map and Track: State Initiatives for Young Children and Families. 1998 Edition.

    ERIC Educational Resources Information Center

    Knitzer, Jane; Page, Stephen

    This report profiles state efforts to develop comprehensive programs and policies for young children and families, presents indicators of child and family well-being, and describes state investments in young children and families. Chapter 1, "Overview of Findings and Implications," identifies the research questions, describes data collection…

  4. Baboon and Young.

    ERIC Educational Resources Information Center

    Hausman, Jerome J.

    1985-01-01

    Discusses Picasso's freestanding sculpture Baboon and Young, and art activities for using the sculpture with elementary and secondary students are suggested. A listing of resources is also included. (RM)

  5. America's Young Adults

    MedlinePlus

    ... with those age 25 and older. Young adults’ employment rates are lower than those of the population ... is associated with many other measures, including income, employment, and political participation, and is an indicator of ...

  6. Young Adult Books.

    ERIC Educational Resources Information Center

    Epstein, Connie C.

    1987-01-01

    Considers the similarities between science fiction writing and young adult literature, and points out that several well-known authors, such as Robert Heinlein and Jane Yolen, write in both genres. (NKA)

  7. Young Adult Books.

    ERIC Educational Resources Information Center

    Rochman, Hazel

    1986-01-01

    Applies the idea of the theme booktalk to "Wuthering Heights," which serves as a springboard for talking about themes of family rage, confrontation, quarrel and rebellion in other works of literature with relevance to contemporary young people. (JK)

  8. Astronaut John Young's Career

    NASA Image and Video Library

    John Young served as a NASA astronaut for over four decades, flying on Gemini, Apollo and the Space Shuttle. He walked on the moon during Apollo 16 in 1972 and commanded the first shuttle mission, ...

  9. Baboon and Young.

    ERIC Educational Resources Information Center

    Hausman, Jerome J.

    1985-01-01

    Discusses Picasso's freestanding sculpture Baboon and Young, and art activities for using the sculpture with elementary and secondary students are suggested. A listing of resources is also included. (RM)

  10. Young Adult Books.

    ERIC Educational Resources Information Center

    Epstein, Connie C.

    1987-01-01

    Considers the similarities between science fiction writing and young adult literature, and points out that several well-known authors, such as Robert Heinlein and Jane Yolen, write in both genres. (NKA)

  11. Suicide Bombers: Profiles, Methods and Techniques

    DTIC Science & Technology

    2007-01-01

    in the makeup of suicide terrorists is “just a myth” and that religious convictions, political sentiments, and social conditions are of secondary...most terrorists are young and that their actions and psychological makeup vary according to social and cultural conditions.22 Professor Ian Ross...of the University of Baltimore provides an alternate view and believes that profiling is possible by combining social factors and psychological

  12. Young onset dementia

    PubMed Central

    Sampson, E; Warren, J; Rossor, M

    2004-01-01

    Young onset dementia is a challenging clinical problem with potentially devastating medical and social consequences. The differential diagnosis is wide, and includes a number of rare sporadic and hereditary diseases. However, accurate diagnosis is often possible, and all patients should be thoroughly investigated to identify treatable processes. This review presents an approach to the diagnosis, investigation, and management of patients with young onset dementia, with particular reference to common and treatable causes. PMID:15016933

  13. Young Stars with SALT

    NASA Astrophysics Data System (ADS)

    Riedel, Adric R.; Alam, Munazza K.; Rice, Emily L.; Cruz, Kelle L.; Henry, Todd J.

    2017-05-01

    We present a spectroscopic and kinematic analysis of 79 nearby M dwarfs in 77 systems. All of these dwarfs are low-proper-motion southern hemisphere objects and were identified in a nearby star survey with a demonstrated sensitivity to young stars. Using low-resolution optical spectroscopy from the Red Side Spectrograph on the South African Large Telescope, we have determined radial velocities, H-alpha, lithium 6708 Å, and potassium 7699 Å equivalent widths linked to age and activity, and spectral types for all of our targets. Combined with astrometric information from literature sources, we identify 44 young stars. Eighteen are previously known members of moving groups within 100 pc of the Sun. Twelve are new members, including one member of the TW Hydra moving group, one member of the 32 Orionis moving group, 9 members of Tucana-Horologium, one member of Argus, and two new members of AB Doradus. We also find 14 young star systems that are not members of any known groups. The remaining 33 star systems do not appear to be young. This appears to be evidence of a new population of nearby young stars not related to the known nearby young moving groups. Based on observations made with the Southern African Large Telescope (SALT).

  14. Speaking Up for Vocabulary: Reading Skill Differences in Young Adults

    ERIC Educational Resources Information Center

    Braze, David; Tabor, Whitney; Shankweiler, Donald P.; Mencl, W. Einar

    2007-01-01

    This study is part of a broader project aimed at developing cognitive and neurocognitive profiles of adolescent and young adult readers whose educational and occupational prospects are constrained by their limited literacy skills. We explore the relationships among reading-related abilities in participants ages 16 to 24 years spanning a wide range…

  15. MRI Neuroanatomy in Young Girls with Autism: A Preliminary Study

    ERIC Educational Resources Information Center

    Bloss, Cinnamon S.; Courchesne, Eric

    2007-01-01

    Objective: To test the hypothesis that young girls and boys with autism exhibit different profiles of neuroanatomical abnormality relative to each other and relative to typically developing children. Method: Structural magnetic resonance imaging was used to measure gray and white matter volumes (whole cerebrum, cerebral lobes, and cerebellum) and…

  16. MRI Neuroanatomy in Young Girls with Autism: A Preliminary Study

    ERIC Educational Resources Information Center

    Bloss, Cinnamon S.; Courchesne, Eric

    2007-01-01

    Objective: To test the hypothesis that young girls and boys with autism exhibit different profiles of neuroanatomical abnormality relative to each other and relative to typically developing children. Method: Structural magnetic resonance imaging was used to measure gray and white matter volumes (whole cerebrum, cerebral lobes, and cerebellum) and…

  17. Acute myocardial infarction in a young woman on isotretinoin treatment.

    PubMed

    Lorenzo, Natalia; Antuña, Paula; Dominguez, Lourdes; Rivero, Fernando; Bastante, Teresa; Alfonso, Fernando

    2015-02-15

    The use of isotretinoin has been associated with mild changes in the metabolic profile of adolescents. In very rare cases, a possible association with myocardial infarction, stroke and thromboembolic events has been reported. In this report we describe the potential association of isotretinoin with the occurrence of an acute myocardial infarction in a very young girl. OCT provided unique visualization of the culprit lesion.

  18. Work readiness tools for young adults with chronic conditions.

    PubMed

    Metzinger, Courtney; Berg, Christine

    2015-01-01

    Young adults with chronic health conditions can experience barriers to work performance, ability, and their present and future worker roles. Work readiness resources can expand individuals' work skills, abilities, and interests. Five work readiness tools are presented (1) building an occupational profile, (2) generating environmental strategies, (3) on-the-job strategy use, and exploration of online tools (4) O*NET® and (5) O*NET® Interest Profiler, along with two theories (Knowles's Andragogy and Lawton's Ecological Model) to guide tool use. Use of these tools can assist young adults to better manage their health and expand their vocational identities for success at work. These approaches and tools support health professionals, community partners, and vocational organizations in their efforts to help young adults with chronic conditions.

  19. Profile of a Growing Urban School: The Lumin Experience

    ERIC Educational Resources Information Center

    Ford, Terry

    2015-01-01

    This fairytale-come-true began with an idealistic public school teacher just out of college who lived in the neighborhood of her students. In stages, working with a community organizing group consisting mainly of concerned parents, Terry Ford founded what is now called Lumin Education, a network of campuses serving more than six hundred children…

  20. Profiling Instructional Package.

    ERIC Educational Resources Information Center

    Gephart, William J.; Bartos, Bruce B.

    The necessity of evaluating research methodology is discussed, and a profiling approach is proposed. Explanatory statements about the research process, directions for doing the actual profiling of the research report, a research profiling flow chart, a research profile sheet, and two additional graphic aids to understanding are included. The…

  1. Pearl I. Young

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Pearl I Young at the NACA Langley Instrument Research Laboratory. She was the Chief Technical Editor at Langley. Pearl Young attended Jamestowm College and the University of North Dakota, graduating in 1919 with honors, a Phi Beta Kappa key and a triple major in physics, chemistry and mathematics. She was hired by the University to teach physics, a role that typically was served by men. In 1921, there were 21 female and 864 male physicists in the United States. Most of the women were college teachers, hired by women's colleges. There was only one woman physicist working for the federal government at that time, and she worked for the National Bureau of Standards. In 1922 Young was hired as a physicist by the National Advisory Committee for Aeronautics (NACA), and was assigned to the Langley Memorial Aeronautical Laboratory's Instrument Research Division under the direction of Henry J.E. Reid. In 1929 Reid appointed Young as Langley's Chief Technical Editor. She established a 'new' office, hired staff and formed the research reports and offical documents that communicated the extraordinary technical accomplishments of Langley. Over her twenty eight years at the NACA and NASA, Young helped define the public image of the NACA and influenced the way aeronautical engineers throughtout NACA (now NASA) communicate their ideas.

  2. Perception of Dialect Variation by Young Adults with High-Functioning Autism

    ERIC Educational Resources Information Center

    Clopper, Cynthia G.; Rohrbeck, Kristin L.; Wagner, Laura

    2012-01-01

    The linguistic profile of people with Autism spectrum disorders typically involves intact perceptual processing, accompanied by deficits in the social functions of language. In a series of three experiments, the impact of this profile on the perception of regional dialect was examined. Young adults with High-Functioning Autism exhibited similar…

  3. Young's equation revisited.

    PubMed

    Makkonen, Lasse

    2016-04-06

    Young's construction for a contact angle at a three-phase intersection forms the basis of all fields of science that involve wetting and capillary action. We find compelling evidence from recent experimental results on the deformation of a soft solid at the contact line, and displacement of an elastic wire immersed in a liquid, that Young's equation can only be interpreted by surface energies, and not as a balance of surface tensions. It follows that the a priori variable in finding equilibrium is not the position of the contact line, but the contact angle. This finding provides the explanation for the pinning of a contact line.

  4. What is Young Adult Literature? (Young Adult Literature).

    ERIC Educational Resources Information Center

    Crowe, Chris, Ed.

    1998-01-01

    Outlines some of the many confusions about young adult literature. Sheds some light on what young adult literature is (defining it as all genres of literature published since 1967 that are written for and marketed to young adults). Discusses briefly how it can be used in schools. Offers a list of the author's 20 favorite books for teenagers. (SR)

  5. Mobility and Young Children.

    ERIC Educational Resources Information Center

    Bernard van Leer Foundation Newsletter, 1994

    1994-01-01

    This newsletter theme issue deals with the phenomenon of mobility or transience in India, Kenya, Greece, Ireland, Malaysia, Thailand and Israel. The primary focus is on mobility's effect on young children, specifically their health and education; some of the broader concerns also addressed by the newsletter are the causes of mobility and its…

  6. Helping Young Hispanic Learners

    ERIC Educational Resources Information Center

    Garcia, Eugene E.; Jensen, Bryant

    2007-01-01

    Hispanics are the largest and youngest ethnic group in the United States. Moreover, young Hispanic children make up approximately 80 percent of the U.S. English language learner population. They are a heterogeneous group, born both inside and outside the United States and having origins in Mexico, Cuba, Central America, South America, and the…

  7. Literature and Young Children.

    ERIC Educational Resources Information Center

    Cullinan, Bernice E., Ed.; Carmichael, Carolyn W., Ed.

    This collection of articles about children's literature contains the following articles: "Books in the Life of the Young Child" and "Traditional Literature: Children's Legacy" by Bernice E. Cullinan, "Encouraging Language Growth" by John Warren Stewig, "Promoting Language and Concept Development" by Dorothy S. Strickland, "Fostering Understanding…

  8. Caring for young forests

    Treesearch

    W. Keith. Moser

    2012-01-01

    Sustaining Young Forest Communities is a good compilation of knowledge about an important forest ecosystem and belongs on the bookshelf of every natural resource practitioner tasked with managing this important resource. One of the principal benefits for anyone who reads this book is that it provides both a broad overview and a reference source for the various...

  9. Helping Young Hispanic Learners

    ERIC Educational Resources Information Center

    Garcia, Eugene E.; Jensen, Bryant

    2007-01-01

    Hispanics are the largest and youngest ethnic group in the United States. Moreover, young Hispanic children make up approximately 80 percent of the U.S. English language learner population. They are a heterogeneous group, born both inside and outside the United States and having origins in Mexico, Cuba, Central America, South America, and the…

  10. Researching Marginalised Young People

    ERIC Educational Resources Information Center

    Russell, Lisa

    2013-01-01

    Young people not in employment, education or training (NEET) are not a static, homogenous group. For most, being NEET is a temporary state as they move between different forms of participation and non-participation. This paper explores how the complexities of defining NEET, the re-structuring of the careers service and the nature of post-16…

  11. Guiding Young Composers

    ERIC Educational Resources Information Center

    Freund, Don

    2011-01-01

    Composition is learned by discovering that musical ideas can be experienced in a variety of ways, and that new musical ideas can be created by reconfiguring learned materials in new contexts. The act of imagining, defining, and communicating unique musical ideas awakens in young people a dormant part of their brains, unlocking an awareness of the…

  12. Violence and Young Children.

    ERIC Educational Resources Information Center

    Sauerwein, Kristina

    1995-01-01

    Schools must increasingly deal with children who brandish weapons and exhibit antisocial or violent behavior. Psychologists agree that young children are very susceptible to violence and that stored violent images can warp their interpretation of reality. To combat youth violence, many schools have adopted antiviolence curricula and conflict…

  13. Transforming Young Lives

    ERIC Educational Resources Information Center

    Larson, Scott

    2014-01-01

    Discussions of transformational change pervade the field of business but are rare in work with young people at risk--those most in need of deep change. Instead, the nation seems preoccupied with punishing or medicating problem behavior. Some propose the alternative of "rehabilitation," but that term means "to restore to former…

  14. Guiding Young Composers

    ERIC Educational Resources Information Center

    Freund, Don

    2011-01-01

    Composition is learned by discovering that musical ideas can be experienced in a variety of ways, and that new musical ideas can be created by reconfiguring learned materials in new contexts. The act of imagining, defining, and communicating unique musical ideas awakens in young people a dormant part of their brains, unlocking an awareness of the…

  15. Reconnecting Disadvantaged Young Men

    ERIC Educational Resources Information Center

    Holzer, Harry; Edelman, Peter; Offner, Paul

    2006-01-01

    By several recent counts, the United States is home to 2 to 3 million youth age 16 through 24 who are out of school and out of work. Much has been written on disadvantaged youth, and government policy has gone through many incarnations, yet questions remain unanswered. Why are so many young people "disconnected," and what can public policy do…

  16. Reconnecting Disadvantaged Young Men

    ERIC Educational Resources Information Center

    Holzer, Harry; Edelman, Peter; Offner, Paul

    2006-01-01

    By several recent counts, the United States is home to 2 to 3 million youth age 16 through 24 who are out of school and out of work. Much has been written on disadvantaged youth, and government policy has gone through many incarnations, yet questions remain unanswered. Why are so many young people "disconnected," and what can public policy do…

  17. The Young Learner.

    ERIC Educational Resources Information Center

    Bonini, Victor

    1987-01-01

    Stresses the need for young children to understand that wild animals should not be kept for pets. Provides lesson plans for physical education, music, and science. Includes suggestions for bulletin boards and learning centers, and a clip art set with figures that are suitable for use with the activities. (TW)

  18. Improving Young People's Concerts.

    ERIC Educational Resources Information Center

    Felder, Harvey

    1998-01-01

    Stresses that symphony orchestras and other professional arts organizations need to improve young people's concerts by accounting for student learning and becoming partners with music educators. Provides an experience hierarchy that helps artists and arts organizations benefit from music teachers' knowledge and a list of five elements to consider…

  19. Transforming Young Lives

    ERIC Educational Resources Information Center

    Larson, Scott

    2014-01-01

    Discussions of transformational change pervade the field of business but are rare in work with young people at risk--those most in need of deep change. Instead, the nation seems preoccupied with punishing or medicating problem behavior. Some propose the alternative of "rehabilitation," but that term means "to restore to former…

  20. [Cardiovascular prevention: begin young].

    PubMed

    Visseren, Frank L J

    2009-01-01

    Atherosclerotic vascular disease is rare in the young. Nevertheless, the foundations for atherosclerotic disease in later life are laid early by a harmful lifestyle including overweight and smoking. Adolescents who are overweight or have the metabolic syndrome are at increased cardiovascular risk later in life.

  1. Mapping with Young Children.

    ERIC Educational Resources Information Center

    Sunal, Cynthia Szymanski; Warash, Bobbi Gibson

    Techniques for encouraging young children to discover the purpose and use of maps are discussed. Motor activity and topological studies form a base from which the teacher and children can build a mapping program of progressive sophistication. Concepts important to mapping include boundaries, regions, exteriors, interiors, holes, order, point of…

  2. Pearl I. Young

    NASA Technical Reports Server (NTRS)

    1929-01-01

    Pearl I. Young, the NACA's first female professional, at work in the instrument research laboratory circa 1929. Photograph published in Winds of Change, 75th Anniversary NASA publication, by James Schultz, page 47. Also published in Engineer in Charge: A History of the Langley Aeronautical Laboratory, 1917-1958 by James R. Hansen, (page 209).

  3. The Young Learner.

    ERIC Educational Resources Information Center

    Bonini, Victor

    1987-01-01

    Stresses the need for young children to understand that wild animals should not be kept for pets. Provides lesson plans for physical education, music, and science. Includes suggestions for bulletin boards and learning centers, and a clip art set with figures that are suitable for use with the activities. (TW)

  4. Laws for Young Mountaineers.

    ERIC Educational Resources Information Center

    Kanawha County Board of Education, Charleston, WV.

    This booklet introduces secondary grade students to the criminal laws of West Virginia. It can easily be adapted and used by educators in other states. The authors believe that young people must recognize and understand these laws and the mechanisms which society uses to implement and enforce them if they are to function as an integral, important,…

  5. Young Craters on Smooth Plains

    NASA Image and Video Library

    2000-01-15

    This image, from NASA Mariner 10 spacecraft which launched in 1974, shows young craters superposed on smooth plains. Larger young craters have central peaks, flat floors, terraced walls, and radial ejecta deposits.

  6. DNA profiles from fingermarks.

    PubMed

    Templeton, Jennifer E L; Linacre, Adrian

    2014-11-01

    Criminal investigations would be considerably improved if DNA profiles could be routinely generated from single fingermarks. Here we report a direct DNA profiling method that was able to generate interpretable profiles from 71% of 170 fingermarks. The data are based on fingermarks from all 5 digits of 34 individuals. DNA was obtained from the fingermarks using a swab moistened with Triton-X, and the fibers were added directly to one of two commercial DNA profiling kits. All profiles were obtained without increasing the number of amplification cycles; therefore, our method is ideally suited for adoption by the forensic science community. We indicate the use of the technique in a criminal case in which a DNA profile was generated from a fingermark on tape that was wrapped around a drug seizure. Our direct DNA profiling approach is rapid and able to generate profiles from touched items when current forensic practices have little chance of success.

  7. GHGRP Industrial Profiles

    EPA Pesticide Factsheets

    EPA's Greenhouse Gas Reporting Program periodically produces detailed profiles of the various industries that report under the program. These profiles contain detailed analyses. This page hosts data highlights for all sectors.

  8. Give It Your Best! Profiles of Native American Athletes.

    ERIC Educational Resources Information Center

    Coker, Russell; Kast, Sherry

    The purpose of this publication is to encourage and enhance the participation of American Indian and Alaska Native athletes in organized sports at the secondary, collegiate, and professional levels. Profiles are given of 37 young Native American women and men who are succeeding in competitive athletics, as well as in the classroom. One page is…

  9. PROFILER: 1D galaxy light profile decomposition

    NASA Astrophysics Data System (ADS)

    Ciambur, Bogdan C.

    2017-05-01

    Written in Python, PROFILER analyzes the radial surface brightness profiles of galaxies. It accurately models a wide range of galaxies and galaxy components, such as elliptical galaxies, the bulges of spiral and lenticular galaxies, nuclear sources, discs, bars, rings, and spiral arms with a variety of parametric functions routinely employed in the field (Sérsic, core-Sérsic, exponential, Gaussian, Moffat and Ferrers). In addition, Profiler can employ the broken exponential model (relevant for disc truncations or antitruncations) and two special cases of the edge-on disc model: namely along the major axis (in the disc plane) and along the minor axis (perpendicular to the disc plane).

  10. Body Odor (For Young Men)

    MedlinePlus

    Young Men's Health http://youngmenshealthsite.org/guides/body-odor/ ≡ Menu Ask Us Health Guides Quizzes Parents About Us Donate ... wear sneakers without socks? Tweets by @YoungMensHealth Young Men’s Health (YMH) is produced by the Division of ...

  11. Letters to a Young Writer.

    ERIC Educational Resources Information Center

    Wright, C. D.; Schulman, Grace

    2001-01-01

    Presents two letters to a young writer, modeled on the influential "Letters to a Young Poet" by Rainer Maria Rilke. Notes the first letter situates itself when a young writer first turns toward poetry; and the second addresses the relationship between mentorship and the imagination, questioning the right of any writer to presume to guide the…

  12. Young Child. [SITE 2001 Section].

    ERIC Educational Resources Information Center

    Yelland, Nicola, Ed.; DeVoogd, Glenn, Ed.

    This document contains the following papers on the young child from the SITE (Society for Information Technology & Teacher Education) 2001 conference: (1) "Young Children and Technology: Building Computer Literacy" (Michael J. Bell and Caroline M. Crawford); (2) "Integrating Technology into the Young Child Lesson Plan"…

  13. [Cardiovascular risk factors in young people].

    PubMed

    Sánchez-Contreras, Mónica; Moreno-Gómez, Germán A; Marín-Grisales, Marta E; García-Ortiz, Luis H

    2009-01-01

    Cardiovascular disease (CVD) involves several disorders related to the formation and development of atherosclerotic processes. Several risk factors are involved in CVD aetiology; some of them (i.e. age, hypertension, obesity, dislipidemia and diabetes) have been clearly associated, whereas others have a variable level of association. An increase in cardiovascular risk factors has been recently reported in the young population; studies of cardiovascular risk factors in this population have shown that its cardiovascular risk profile could be different from that presented by older populations. This review presents a summary of reported cardiovascular risk factors in the young population and their causes which have been released and indexed in different databases. Most factors discussed are life-habit risk factors and represent direct targets for clinical intervention. We propose that primary CVD prevention should include a more detailed knowledge of the nature of the risk factors concerning the young population and could have a positive impact on CVD prevalence during the next few years.

  14. Young Crater - Again

    NASA Image and Video Library

    2017-02-03

    This image from NASA 2001 Mars Odyssey spacecraft shows the same young crater from earlier this week. In this image we can see how the thin radial ejecta has lapped up and over the ridge at the bottom of the image. Orbit Number: 66654 Latitude: -44.4179 Longitude: 139.201 Instrument: VIS Captured: 2016-12-23 04:04 http://photojournal.jpl.nasa.gov/catalog/PIA21303

  15. Young children's harmonic perception.

    PubMed

    Costa-Giomi, Eugenia

    2003-11-01

    Harmony and tonality are two of the most difficult elements for young children to perceive and manipulate and are seldom taught in the schools until the end of early childhood. Children's gradual harmonic and tonal development has been attributed to their cumulative exposure to Western tonal music and their increasing experiential knowledge of its rules and principles. Two questions that are relevant to this problem are: (1) Can focused and systematic teaching accelerate the learning of the harmonic/tonal principles that seem to occur in an implicit way throughout childhood? (2) Are there cognitive constraints that make it difficult for young children to perceive and/or manipulate certain harmonic and tonal principles? A series of studies specifically addressed the first question and suggested some possible answers to the second one. Results showed that harmonic instruction has limited effects on children's perception of harmony and indicated that the drastic improvement in the perception of implied harmony noted approximately at age 9 is due to development rather than instruction. I propose that young children's difficulty in perceiving implied harmony stems from their attention behaviors. Older children have less memory constraints and more strategies to direct their attention to the relevant cues of the stimulus. Younger children focus their attention on the melody, if present in the stimulus, and specifically on its concrete elements such as rhythm, pitch, and contour rather than its abstract elements such as harmony and key. The inference of the abstract harmonic organization of a melody required in the perception of implied harmony is thus an elusive task for the young child.

  16. The Shergotites Are Young

    NASA Technical Reports Server (NTRS)

    Jones, John H.

    2007-01-01

    Recently, Bouvier et al. (2006), interpreting their Pb isotopic data, have inferred that the shergottite suite of the SNC (martian) meteorites have ancient ages of approximately 4-4.5 b.y. But conventional wisdom has it that the shergottites are much younger (approximately 500-150 m.y.) Are the shergottites young or are they ancient rocks whose ages have been reset by metamorphism or alteration?

  17. Violence and Personality in Forensic Patients: Is There a Forensic Patient-Specific Personality Profile?

    ERIC Educational Resources Information Center

    Stupperich, Alexandra; Ihm, Helga; Strack, Micha

    2009-01-01

    Concerning the discussion about the connection of personality traits, personality disorders, and mental illness, this study focused on the personality profiles of male forensic patients, prison inmates, and young men without criminal reports. The main topic centered on group-specific personality profiles and identifying personality facets…

  18. Violence and Personality in Forensic Patients: Is There a Forensic Patient-Specific Personality Profile?

    ERIC Educational Resources Information Center

    Stupperich, Alexandra; Ihm, Helga; Strack, Micha

    2009-01-01

    Concerning the discussion about the connection of personality traits, personality disorders, and mental illness, this study focused on the personality profiles of male forensic patients, prison inmates, and young men without criminal reports. The main topic centered on group-specific personality profiles and identifying personality facets…

  19. The Quality of Perceived Parenting Experienced by a Group of Scottish Incarcerated Young Offenders and Its Relation to Psychological Distress.

    ERIC Educational Resources Information Center

    Biggam, Fiona H.; Power, Kevin G.

    1998-01-01

    Utilizes the Parental Bonding Instrument with a group of 125 incarcerated Scottish young offenders 16-21 years old. Examines the response profiles of young participants and compares the results to normative data and demographics relating to family and penal experiences. Also investigates relationships between parenting style and levels of…

  20. The Quality of Perceived Parenting Experienced by a Group of Scottish Incarcerated Young Offenders and Its Relation to Psychological Distress.

    ERIC Educational Resources Information Center

    Biggam, Fiona H.; Power, Kevin G.

    1998-01-01

    Utilizes the Parental Bonding Instrument with a group of 125 incarcerated Scottish young offenders 16-21 years old. Examines the response profiles of young participants and compares the results to normative data and demographics relating to family and penal experiences. Also investigates relationships between parenting style and levels of…

  1. Career Advice for Young Allergy Patients.

    PubMed

    Radon, Katja; Nowak, Dennis; Vogelberg, Christian; Ruëff, Franziska

    2016-08-08

    One-third of all young persons entering the work force have a history of atopic disease. Occupationally induced allergy and asthma generally arise in the first few months on the job, while pre-existing symptoms tend to worsen. Young persons with a history of an atopic disease should receive evidence-based advice before choosing a career. We systematically searched PubMed for cohort studies investigating the new onset of asthma, rhinitis, or hand eczema among job trainees from before the start of training and onward into the first few years on the job. The search revealed 514 articles; we read their abstracts and selected 85 full-text articles for further analysis. 24 of these met the inclusion criteria. According to present evidence, atopy and a history of allergic disease (allergic rhinitis, atopic dermatitis) are the main risk factors for occupationally induced disease. The predictive value of a personal history of allergic diseases for the later development of an occupationally induced disease varies from 9% to 64% in the studies we analyzed. It follows that only young people with severe asthma or severe atopic eczema should be advised against choosing a job that is associated with a high risk of allergy, e.g., hairdressing or working with laboratory animals. Young people with a history of other atopic diseases should be counseled about their individual risk profile. In view of the relatively poor predictive value of pre-existing atopic disease, secondary prevention is particularly important. This includes frequent medical follow-up of the course of symptoms over the first few years on the job. If sensitization or allergic symptoms arise, it should be carefully considered whether exposure reduction will enable the apprentice to stay on the job.

  2. Isometric shoulder strength in young swimmers.

    PubMed

    McLaine, Sally J; Ginn, Karen A; Fell, James W; Bird, Marie-Louise

    2017-05-25

    The prevalence of shoulder pain in young swimmers is high. Shoulder rotation strength and the ratio of internal to external rotation strength have been reported as potential modifiable risk factors associated with shoulder pain. However, relative strength measures in elevated positions, which include flexion and extension, have not been established for the young swimmer. The aim of this study was to establish clinically useful, normative shoulder strength measures and ratios for swimmers (14-20 years) without shoulder pain. Cross-sectional, observational study. Swimmers (N=85) without a recent history of shoulder pain underwent strength testing of shoulder flexion and extension (in 140° abduction); and internal and external rotation (in 90° abduction). Strength tests were performed in supine using a hand-held dynamometer and values normalised to body weight. Descriptive statistics were calculated for strength and strength ratios (flexion:extension and internal:external rotation). Differences between groups (based on gender, history of pain, test and arm dominance) were explored using independent and paired t tests. Normative shoulder strength values and ratios were established for young swimmers. There was a significant difference (p<0.002) in relative strength between males and females for all tests with no differences in strength ratios. Relative strength of the dominant and non-dominant shoulders (except for extension); and for swimmers with and without a history of shoulder pain was not significantly different. A normal shoulder strength profile for the young swimmer has been established which provides a valuable reference for the clinician assessing shoulder strength in this population. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  3. Investing in the health and well-being of young adults.

    PubMed

    Stroud, Clare; Walker, Leslie R; Davis, Maryann; Irwin, Charles E

    2015-02-01

    Contrary to popular perception, young adults-ages approximately 18-26 years-are surprisingly unhealthy. They are less healthy than adolescents, and they also show a worse health profile than those in their late 20s and 30s. The Affordable Care Act provisions to extend coverage for young adults are well known, and some states had already been pursuing similar efforts before the Affordable Care Act was enacted. These initiatives have resulted in important gains in young adults' heath care coverage. However, too little attention has been paid to the care that young adults receive once they are in the system. Given young adults' health problems, this is a critical omission. The Institute of Medicine and National Research Council recently released a report titled Investing in the Health and Well-Being of Young Adults. The report concludes that young adulthood is a critical developmental period and recommends that young adults ages 18-26 years be treated as a distinct subpopulation in policy, planning, programming, and research. The report also recommends action in three priority areas to improve health care for young adults: improving the transition from pediatric to adult medical and behavioral health care, enhancing preventive care for young adults, and developing evidence-based practices. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  4. The All Sky Young Association (ASYA): a New Young Association

    NASA Astrophysics Data System (ADS)

    Torres, C. A. O.; Quast, G. R.; Montes, D.

    2016-01-01

    To analyze the SACY (Search for Associations Containing Young stars) survey we developed a method to find young associations and to define their high probability members. These bona fide members enable to obtain the kinematical and the physical properties of each association in a proper way. Recently we noted a concentration in the UV plane and we found a new association we are calling ASYA (All Sky Young Association) for its overall distribution in the sky with a total of 38 bonafide members and an estimated age of 110 Myr, the oldest young association found in the SACY survey. We present here its kinematical, space and Li distributions and its HR diagram.

  5. Colorado wind profilers

    NASA Technical Reports Server (NTRS)

    Strauch, R. G.

    1986-01-01

    The Wave Propagation Laboratory (WPL) has operated a network of wind profiling radars in Colorado. The current configuration of the network is described. All radars operate continuously and unattended to supply hourly-averaged wind profiles to a central computer in Boulder in real time. The hardware and software changes made to improve reliability are discussed. This research network will continue to be used to provide wind profiles for operational and research meteorologists and the performance of various wavelength systems will be evaluated.

  6. Deprojecting the nasal profile.

    PubMed

    Papel, I D; Mabrie, D C

    1999-02-01

    The nose is the most prominent aesthetic feature of the facial profile. Nasal length, tip rotation, and tip projection are integral aspects in analysis of the nasal profile. In most rhinoplasties the surgeon has the difficult task of increasing or maintaining tip projection of an underprojected or normally projected nasal tip. Less commonly, the rhinoplastic surgeon is presented with an overprojected nasal tip, and efforts are focused on deprojecting the nasal profile. In this article, the authors present a discussion of the overprojected tip, elucidating strategies of analysis, etiologies, and management of the nasal profile and give clinical examples.

  7. The pervasiveness, connectedness, and intrusiveness of social network site use among young adolescents.

    PubMed

    Espinoza, Guadalupe; Juvonen, Jaana

    2011-12-01

    Young adolescents are quickly becoming avid users of social networking sites (SNSs); however, little is known regarding how they use these sites. The goal of the present study was to examine the extent to which young adolescents use SNSs, with whom they connect via these sites, and whether SNS use disrupts daily functioning. Among 268 middle-school students surveyed, 63% reported having their own profile page on an SNS. On average, adolescents reported having 196 SNS contacts (friends), most of whom were known peers. Young adolescents with an SNS spent most of their time viewing and responding to comments written on their profile page. Among the SNS users, 39% reported getting behind on schoolwork and 37% reported losing sleep at least once because they were visiting an SNS. As SNS use becomes embedded in young teens' daily lives, it is important to better understand how such use affects their daily adaptive functioning.

  8. The Young Ones

    NASA Image and Video Library

    2015-03-16

    This high-resolution view shows hollows on the southwestern peak ring of the Scarlatti basin. The hollows are the irregularly shaped, flat-floored depressions. The image is striking because it shows that there are abundant small impact craters on the surface surrounding the hollows. But there are few if any within the hollows themselves. Since impacts occur randomly over Mercury's surface and accumulate with time, the lack of craters on the hollows indicates that they must be very young relative to the rest of Mercury's surface. http://photojournal.jpl.nasa.gov/catalog/PIA19246

  9. Immune System Transcriptome in Gingival Tissues of Young Nonhuman Primates

    PubMed Central

    Gonzalez, O.A.; Nagarajan, R.; Novak, M.J.; Orraca, L.; Gonzalez-Martinez, J.A.; Kirakodu, S. S.; Ebersole, J.L.

    2015-01-01

    Young/adolescent humans demonstrate many microorganisms associated with periodontal disease in adults and substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft and hard tissue destruction that hallmark periodontitis. This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (<3 years old) compared to older animals (5-23 years old). Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed at least across one of the age comparisons. Correlation metrics generated a relevance network abstraction of these genes. Partitioning of the relevance network revealed seven distinct communities comprising functionally related genes associated with host inflammatory and immune responses. A group of genes were identified that were selectively increased/decreased or positively/negatively correlated with gingival profiles in the animals. A Principal Components Analysis created metagenes of expression profiles for classifying the 23 animals. The results provide novel system-level insights into gene expression differences in healthy young tissues weighted towards host responses that were associated with anti-inflammatory biomolecules or those linked with T cell regulation of responses. The combination of the regulated microenvironment may help to explain the apparent “resistance” of younger individuals to developing periodontal disease. PMID:26077888

  10. Measurement of aesthetic proportions in the profile view of Koreans.

    PubMed

    Wang, Jong Hwan; Jang, Yong Ju; Park, Soo-Kyung; Lee, Bong-Jae

    2009-02-01

    We have evaluated the usefulness of direct soft tissue measurements in profile photographs for determining the nasal proportions and angles of young Korean individuals and those of rhinoplasty patients, and we compared these findings with existing norms of Caucasian populations. We retrospectively compared preoperative profile measurements of nasal length, nasal tip projection, dorsal height, radix height, nasolabial angle, and nasofrontal angle in 123 patients who underwent rhinoplasty, with measurements in 21 young Korean adults. Rhinoplasty patients were grouped by preoperative diagnosis as deviated nose without saddle or hump, saddle nose, hump nose, and low radix. The young Koreans had a nasal length to nasal tip projection to dorsal height to radix height ratio of 2:0.97:0.61:0.28. Dorsal height differed significantly among groups of rhinoplasty patients. Those with low radix had the lowest dorsal and radix height, whereas those with saddle nose had the smallest nasal tip projection. The average nasolabial and nasofrontal angles were 78.5 degrees and 82.7 degrees, respectively, in young male Koreans and 126.0 degrees and 133.6 degrees, respectively, in young female Koreans. In the deviated nose group, all parameters except for nasofrontal angle were significantly changed after rhinoplasty. In the saddle nose group, nasal tip projection and dorsal height were significantly increased, whereas, in the hump nose group, nasal tip projection and nasolabial angle were significantly altered. Direct soft tissue measurement on profile photographs is useful for assessing nasal characteristics and postrhinoplasty outcomes. Compared with Caucasians, young Koreans had relatively lower dorsum and radix and more acute nasolabial angle, but similar nasofrontal angle.

  11. The young female athlete.

    PubMed

    Hurvitz, Michal; Weiss, Ram

    2009-12-01

    Participation of adolescents and young women in strenuous sports activity may lead to various metabolic and psychological derangements of clinical relevance to the endocrinologist. The most common manifestations encountered in practice are primary and secondary amenorrhea, reduced bone mineral density and eating disorders. The occurrence of all three together has been named "the athletic triad". The underlying hormonal drivers that lead to some of these manifestations are the reduced leptin level as well as the persistent low grade stress response commonly observed in such females. "Exercise-related female reproductive dysfunction" (ERFRD), can possibly include short-term (infertility) and long-term (osteoporosis) consequences. Functional hypothalamic amenorrhea, a manifestation of ERFRD in adolescence, is an integrated response to the combination of excessive physical and emotional stress, exercise, and/or reduced food intake characterized by decreased endogenous GNRH secretion. The primary aim of treating these athletes should be the prevention of the development of any component of the triad as well as the whole complex by educating athletes, trainers, parents and health care professionals about proper nutrition and safe training. The long term prognosis is good. However, significant long term morbidity may affect these young women later in life.

  12. Sexing young snowy owls

    USGS Publications Warehouse

    Seidensticker, M.T.; Holt, D.W.; Detienne, J.; Talbot, S.; Gray, K.

    2011-01-01

    We predicted sex of 140 Snowy Owl (Bubo scandiacus) nestlings out of 34 nests at our Barrow, Alaska, study area to develop a technique for sexing these owls in the field. We primarily sexed young, flightless owls (3844 d old) by quantifying plumage markings on the remiges and tail, predicting sex, and collecting blood samples to test our field predictions using molecular sexing techniques. We categorized and quantified three different plumage markings: two types of bars (defined as markings that touch the rachis) and spots (defined as markings that do not touch the rachis). We predicted sex in the field assuming that males had more spots than bars and females more bars than spots on the remiges and rectrices. Molecular data indicated that we correctly sexed 100% of the nestlings. We modeled the data using random forests and classification trees. Both models indicated that the number and type of markings on the secondary feathers were the most important in classifying nestling sex. The statistical models verified our initial qualitative prediction that males have more spots than bars and females more bars than spots on flight feathers P6P10 for both wings and tail feathers T1 and T2. This study provides researchers with an easily replicable and highly accurate method for sexing young Snowy Owls in the field, which should aid further studies of sex-ratios and sex-related variation in behavior and growth of this circumpolar owl species. ?? 2011 The Raptor Research Foundation, Inc.

  13. [Time to be young].

    PubMed

    1997-01-01

    The project entitled "Tempo de ser jovem" (time to be young) is implemented in Campanha, in the city of Porto, Portugal, to prevent dropping out from schools, drug abuse, and adolescent pregnancy in the Elementary School of Cerco, Porto, where many pupils have problems with fitting in owing to socioeconomic disadvantages and underprivileged status. The project was developed by the professionals of the local health center and by some teachers. Youth groups were formed to perform activities in health, the environment, social communication, and sports. The prevention of rising adolescent pregnancy was a goal because 25% of all births occur to girls aged 19 and under. Family planning is also vital because of the frequency of repeated pregnancies. Psychologists render counseling assistance to young people and local employment centers also offer social and vocational assistance in gardening, cleaning and domestic work in residential quarters. In the family planning courses groups of 15-20 persons are included and practical training is carried out dealing with nutrition during pregnancy as well as for adolescents and nursing mothers. Visits to homes of parents are also made and individual consultation is also offered. Motivation is the mainstay of all activities dealing with psychosocial aspects of adolescent pregnancy and motherhood, health and disease, and social marketing.

  14. Sexting among young adults

    PubMed Central

    Gordon-Messer, Deborah; Bauermeister, Jose Arturo; Grodzinski, Alison; Zimmerman, Marc

    2012-01-01

    Purpose Sexting has stirred debate over its legality and safety, but few researchers have documented the relationship between sexting and health. We describe the sexting behavior of young adults in the United States, and examine its association with sexual behavior and psychological well-being. Methods Using an adapted web version of Respondent-Driven Sampling (webRDS) we recruited a sample of U.S. young adults (ages 18 to 24; N=3447). We examined participant sexting behavior using 4 categories of sexting: 1) Non-Sexters, 2) Receivers, 3) Senders, and 4) Two-way Sexters. We then assessed the relationships between sexting categories and sociodemographic characteristics, sexual behavior and psychological well-being. Results Over half (57%) of respondents were Non-Sexters, 28.2% of the sample were Two-way Sexters, 12.6% were Receivers, and 2% were Senders. Males were more likely to be Receivers than females. Sexually active respondents were more likely to be Two-way Sexters than non-sexually active respondents. Among participants who were sexually active in the past 30 days, we found no differences across sexting groups in number of sexual partners, or number of unprotected sex partners in the past 30 days. We also found no relationship between sexting and psychological well-being. Conclusions Our results suggest that sexting is not related to sexual risk behavior or psychological well-being. We discuss the findings of this study and propose directions for further research on sexting. PMID:23299018

  15. Campus Profile 98.

    ERIC Educational Resources Information Center

    Glendale Community Coll., CA. Planning and Research Office.

    Glendale Community College's Campus Profile is designed to assist faculty, staff, and students in understanding the college's diverse operations. Organized around an outline from the state accountability model, this statistical report focuses on the academic years 1995-1997. "Campus Profile '98" includes more accountability performance…

  16. Profiles of California vegetation

    Treesearch

    William B. Critchfield

    1971-01-01

    This publication brings together 57 elevational profiles illustrating the dominant vegetation of much of the Sierra Nevada, southern Coast Ranges, and montane southern California as it existed in the 1930's. The profiles were drawn by Michael N. Dobrotin for the U.S. Forest Service's Vegetation Type Map survey, which mapped nearly half of the State's...

  17. Florida Language Profile Manual.

    ERIC Educational Resources Information Center

    Wolking, William D.; And Others

    Described in the manual is the Florida Language Profile (funded through Title VI), a flexible set of performance sampling procedures for measuring language cognitive skills of children in kindergarten and grade 1 and remediating diagnosed disabilities. It is said that the Profile may be administered by the trained examiner or classroom teacher on…

  18. Young Migrants and Discourses on Young Migrants in the Netherlands

    ERIC Educational Resources Information Center

    Gerritsen, Debby; Maier, Robert

    2012-01-01

    This article compares the perspectives of young migrants in the Netherlands with the dominant discourse on "migrants" at present. The integration of young "migrants" have been studied in the European research projects TRESEGY and PROFACITY with the help of a number of ethnographic studies and a questionnaire in the Netherlands.…

  19. Young Migrants and Discourses on Young Migrants in the Netherlands

    ERIC Educational Resources Information Center

    Gerritsen, Debby; Maier, Robert

    2012-01-01

    This article compares the perspectives of young migrants in the Netherlands with the dominant discourse on "migrants" at present. The integration of young "migrants" have been studied in the European research projects TRESEGY and PROFACITY with the help of a number of ethnographic studies and a questionnaire in the Netherlands.…

  20. Risk factors for young-onset invasive and in situ breast cancer.

    PubMed

    O'Brien, Katie M; Sun, Jenny; Sandler, Dale P; DeRoo, Lisa A; Weinberg, Clarice R

    2015-12-01

    Young-onset breast cancers tend to be more aggressive than later-onset tumors and may have different risk factor profiles. Among young-onset cases, there may also be etiologic differences between ductal carcinomas in situ (DCIS) and invasive breast cancer, particularly if some factors promote malignant transformation. We evaluated the association between several potential risk factors and young-onset breast cancer in the Two Sister Study (2008-2010), a sister-matched case-control study involving 1,406 women diagnosed with breast cancer before age 50 (1,185 invasive, 221 DCIS) and 1,648 controls. Older age at menarche, younger age at menopause, premenopausal hysterectomy, early age at first-term pregnancy, obesity, and consumption of alcohol were associated with reduced risk of young-onset breast cancer. These patterns remained when we limited analysis to invasive breast cancers. In general, effect estimates were similar for young-onset invasive breast cancer and DCIS, although the number of DCIS cases was small. In this sister-matched case-control study of young-onset breast cancer, many of the studied risk factors were associated with young-onset invasive breast cancer. There were few discernable differences in risk factors for young-onset DCIS versus young-onset invasive breast cancer.

  1. Estimating Cognitive Profiles Using Profile Analysis via Multidimensional Scaling (PAMS)

    ERIC Educational Resources Information Center

    Kim, Se-Kang; Frisby, Craig L.; Davison, Mark L.

    2004-01-01

    Two of the most popular methods of profile analysis, cluster analysis and modal profile analysis, have limitations. First, neither technique is adequate when the sample size is large. Second, neither method will necessarily provide profile information in terms of both level and pattern. A new method of profile analysis, called Profile Analysis via…

  2. Estimating Cognitive Profiles Using Profile Analysis via Multidimensional Scaling (PAMS)

    ERIC Educational Resources Information Center

    Kim, Se-Kang; Frisby, Craig L.; Davison, Mark L.

    2004-01-01

    Two of the most popular methods of profile analysis, cluster analysis and modal profile analysis, have limitations. First, neither technique is adequate when the sample size is large. Second, neither method will necessarily provide profile information in terms of both level and pattern. A new method of profile analysis, called Profile Analysis via…

  3. Post-traumatic knee osteoarthritis in the young patient: therapeutic dilemmas and emerging technologies.

    PubMed

    Stiebel, Matthew; Miller, Larry E; Block, Jon E

    2014-01-01

    Traumatic knee injury is common in young adults and strongly contributes to premature development of knee osteoarthritis (OA). Post-traumatic knee OA poses a therapeutic dilemma to the physician, since no known therapy has an acceptable safety profile, effectively relieves joint pain, and enjoys reasonable patient acceptance. Consequently, these young patients will ultimately be faced with the decision to either undergo surgical intervention, despite prosthesis durability concerns, or to continue with ineffective nonsurgical treatment. Emerging therapies, such as biologics, disease-modifying drugs, partial joint resurfacings, and minimally invasive joint-unloading implants are currently being studied to fill this therapeutic void in the young patient with post-traumatic knee OA.

  4. Feb. 11, 1998 Letter to Terry Godar on MSW Landfills

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  5. An Absorbing Look at Terry-Cloth Towels

    ERIC Educational Resources Information Center

    Moyer, Richard; Everett, Susan

    2010-01-01

    This article describes a lesson where students explore the absorbency of several towels with different weaves and weights. The lesson follows the 5E learning-cycle model and incorporates engineering in the sense of product testing with a focus on the relationship between the weave of a towel and its absorbency. The National Science Education…

  6. Coming to Terms with Perfection: The Case of Terri Schiavo

    ERIC Educational Resources Information Center

    Hyde, Michael J.; McSpiritt, Sarah

    2007-01-01

    Our project is intended to supplement and extend research that emphasizes how the rhetoric informing the euthanasia debate admits a call of conscience and how this call would have us act heroically as we acknowledge what is arguably some particular truth that is at work in the debate (e.g., only God has the right to take a life). The relationship…

  7. Coming to Terms with Perfection: The Case of Terri Schiavo

    ERIC Educational Resources Information Center

    Hyde, Michael J.; McSpiritt, Sarah

    2007-01-01

    Our project is intended to supplement and extend research that emphasizes how the rhetoric informing the euthanasia debate admits a call of conscience and how this call would have us act heroically as we acknowledge what is arguably some particular truth that is at work in the debate (e.g., only God has the right to take a life). The relationship…

  8. An Absorbing Look at Terry-Cloth Towels

    ERIC Educational Resources Information Center

    Moyer, Richard; Everett, Susan

    2010-01-01

    This article describes a lesson where students explore the absorbency of several towels with different weaves and weights. The lesson follows the 5E learning-cycle model and incorporates engineering in the sense of product testing with a focus on the relationship between the weave of a towel and its absorbency. The National Science Education…

  9. Spatial navigation in young versus older adults

    PubMed Central

    Gazova, Ivana; Laczó, Jan; Rubinova, Eva; Mokrisova, Ivana; Hyncicova, Eva; Andel, Ross; Vyhnalek, Martin; Sheardova, Katerina; Coulson, Elizabeth J.; Hort, Jakub

    2013-01-01

    Older age is associated with changes in the brain, including the medial temporal lobe, which may result in mild spatial navigation deficits, especially in allocentric navigation. The aim of the study was to characterize the profile of real-space allocentric (world-centered, hippocampus-dependent) and egocentric (body-centered, parietal lobe dependent) navigation and learning in young vs. older adults, and to assess a possible influence of gender. We recruited healthy participants without cognitive deficits on standard neuropsychological testing, white matter lesions or pronounced hippocampal atrophy: 24 young participants (18–26 years old) and 44 older participants stratified as participants 60–70 years old (n = 24) and participants 71–84 years old (n = 20). All underwent spatial navigation testing in the real-space human analog of the Morris Water Maze, which has the advantage of assessing separately allocentric and egocentric navigation and learning. Of the eight consecutive trials, trials 2–8 were used to reduce bias by a rebound effect (more dramatic changes in performance between trials 1 and 2 relative to subsequent trials). The participants who were 71–84 years old (p < 0.001), but not those 60–70 years old, showed deficits in allocentric navigation compared to the young participants. There were no differences in egocentric navigation. All three groups showed spatial learning effect (p’ s ≤ 0.01). There were no gender differences in spatial navigation and learning. Linear regression limited to older participants showed linear (β = 0.30, p = 0.045) and quadratic (β = 0.30, p = 0.046) effect of age on allocentric navigation. There was no effect of age on egocentric navigation. These results demonstrate that navigation deficits in older age may be limited to allocentric navigation, whereas egocentric navigation and learning may remain preserved. This specific pattern of spatial navigation impairment may help differentiate normal aging from

  10. Sport nutrition for young athletes.

    PubMed

    Purcell, Laura K

    2013-04-01

    Nutrition is an important part of sport performance for young athletes, in addition to allowing for optimal growth and development. Macronutrients, micronutrients and fluids in the proper amounts are essential to provide energy for growth and activity. To optimize performance, young athletes need to learn what, when and how to eat and drink before, during and after activity.

  11. Young Agricultural Workers in California.

    ERIC Educational Resources Information Center

    Arroyo, Michele Gonzalez; Kurre, Laura

    This report examines the extent to which young people work in California agriculture and describes work-related hazards and injuries among young agricultural workers. Data were gathered through a literature review; discussion groups with parents, community groups, and English-as-a-second-language students in the San Joaquin Valley; surveys of 295…

  12. Sport nutrition for young athletes

    PubMed Central

    Purcell, Laura K

    2013-01-01

    Nutrition is an important part of sport performance for young athletes, in addition to allowing for optimal growth and development. Macronutrients, micronutrients and fluids in the proper amounts are essential to provide energy for growth and activity. To optimize performance, young athletes need to learn what, when and how to eat and drink before, during and after activity. PMID:24421690

  13. Injuries to the Young Athlete.

    ERIC Educational Resources Information Center

    Sandusky, Jane C.

    A review of literature on the incidence and nature of injuries to young athletes is presented on the topics of: (1) physiological characteristics of preadolescents, adolescents, and young adults; (2) musculo-skeletal changes in the growing athlete; (3) epiphyseal injuries and their potential for resulting in temporary or permanent impairment; (4)…

  14. Discovering Nature with Young Children.

    ERIC Educational Resources Information Center

    Chalufour, Ingrid; Worth, Karen

    Young children's curiosity about nature and their need to make sense of the world presents an opportunity to incorporate science as a natural and critical part of children's early learning. This guide, part of a preschool science curriculum, uses an inquiry approach to encourage young naturalists to observe life more closely, build an…

  15. Young Peoples' Ideas of Infinity.

    ERIC Educational Resources Information Center

    Monaghan, John

    2001-01-01

    Considers young peoples' views of infinity prior to instruction in the methods mathematicians use in addressing the subject of infinity. Presents a partially historical account of studies examining young peoples' ideas of infinity. Four sections address potential pitfalls for research in this area and the work of Piaget, issues concerning the…

  16. Young Child. [SITE 2002 Section].

    ERIC Educational Resources Information Center

    Yelland, Nicola, Ed.; DeVoogd, Glenn, Ed.

    This document contains the following papers on the young child from the SITE (Society for Information Technology & Teacher Education) 2002 conference: (1) "Young Children's Computer Use: Perspectives of Early Childhood Teacher Educators" (Mehmet Buldu); (2) "Using Technology To Support Preschool Teachers' Professional Development" (Julie Hirschler…

  17. Young Children's Understanding of Denial

    ERIC Educational Resources Information Center

    Austin, Keith; Theakston, Anna; Lieven, Elena; Tomasello, Michael

    2014-01-01

    Although a fair amount is known about young children's production of negation, little is known about their comprehension. Here, we focus on arguably the most complex basic form, denial, and how young children understand denial, when it is expressed in response to a question with gesture, single word, or sentence. One hundred twenty-six children in…

  18. Hip injuries in young athletes.

    PubMed

    Smith, David V; Bernhardt, David T

    2010-01-01

    The hip is an area of the body commonly injured in athletes and one that requires special consideration in the pediatric and adolescent athlete. This article reviews diagnoses specific to the young athlete and discusses more recent advances in imaging of the hip and arthroscopic treatment of the hip in the young athlete.

  19. Using Puppets with Young Children.

    ERIC Educational Resources Information Center

    Skelton, Sarah C.; Hamilton, Anne C.

    This paper examines aspects of the use of puppets with young children and provides guidelines on proper times for puppet use, basic movements, and patterns. The use of puppetry in dramatic play provides young children with opportunities for refining communication skills and defining self. Puppetry provides a means for children to explore their…

  20. Using Puppets with Young Children.

    ERIC Educational Resources Information Center

    Skelton, Sarah C.; Hamilton, Anne C.

    This paper examines aspects of the use of puppets with young children and provides guidelines on proper times for puppet use, basic movements, and patterns. The use of puppetry in dramatic play provides young children with opportunities for refining communication skills and defining self. Puppetry provides a means for children to explore their…

  1. Researchers Noticing Young Children's Mathematics

    ERIC Educational Resources Information Center

    Clarke, Barbara

    2013-01-01

    Noticing young children's mathematics can involve talking to them and watching as they undertake mathematical tasks or answer questions. Interviews are a key methodology for researchers who focus on young children's mathematical learning, providing opportunities to notice what children are doing and gain insights into their thinking. This paper…

  2. Young People and Contemporary Art

    ERIC Educational Resources Information Center

    Illeris, Helene

    2005-01-01

    In this article empirical examples are used to connect theories about young people, contemporary art forms and learning. The first part of the article introduces the new forms of consciousness which, according to the youth researchers Birgitte Simonsen and Thomas Ziehe, characterize young people of today. In the second part, the qualities of…

  3. Leading Work with Young People

    ERIC Educational Resources Information Center

    Harrison, Roger, Ed.; Benjamin, Cathy, Ed.; Curran, Sheila, Ed.; Hunter, Rob, Ed.

    2007-01-01

    "Leading Work with Young People" provides a selection of writing from a complex and dynamic field of work. The editors bring together key readings and newly commissioned material to present a variety of theoretical and practical perspectives on leading and managing work with young people. The book will equip students with the knowledge, skills,…

  4. Leading Work with Young People

    ERIC Educational Resources Information Center

    Harrison, Roger, Ed.; Benjamin, Cathy, Ed.; Curran, Sheila, Ed.; Hunter, Rob, Ed.

    2007-01-01

    "Leading Work with Young People" provides a selection of writing from a complex and dynamic field of work. The editors bring together key readings and newly commissioned material to present a variety of theoretical and practical perspectives on leading and managing work with young people. The book will equip students with the knowledge, skills,…

  5. Focus on Young Adult Programming.

    ERIC Educational Resources Information Center

    Union, Bunni; Williams, Sheila

    1996-01-01

    Presents three library youth service programs which focus on "Pizza and Politicians," a public library pizza party which gave high school students and college-aged young adults a chance to meet and question politicians; a young adult "Reading to Seniors" program; "Making Books," a public library journal-making project…

  6. Nutrition for the young athlete.

    PubMed

    Meyer, Flavia; O'Connor, Helen; Shirreffs, Susan M

    2007-01-01

    Athletics is a popular sport among young people. To maintain health and optimize growth and athletic performance, young athletes need to consume an appropriate diet. Unfortunately, the dietary intake of many young athletes follows population trends rather than public health or sports nutrition recommendations. To optimize performance in some disciplines, young athletes may strive to achieve a lower body weight or body fat content and this may increase their risk for delayed growth and maturation, amenorrhoea, reduced bone density, and eating disorders. Although many of the sports nutrition principles identified for adults are similar to those for young athletes, there are some important differences. These include a higher metabolic cost of locomotion and preferential fat oxidation in young athletes during exercise. Young athletes, particularity children, are at a thermoregulatory disadvantage due to a higher surface area to weight ratio, a slower acclimatization, and lower sweating rate. An appropriate dietary intake rather than use of supplements (except when clinically indicated) is recommended to ensure young athletes participate fully and safely in athletics.

  7. Literature for Today's Young Adults.

    ERIC Educational Resources Information Center

    Donelson, Kenneth L.; Nilsen, Alleen Pace

    Defining young adult literature to include any book freely chosen for reading by a person between the ages of 12 and 20, this book is intended to help educate professionals in related fields about the growing body of such literature. The first section of the book provides an introduction to young adult literature, including a discussion of the…

  8. Discovering Nature with Young Children.

    ERIC Educational Resources Information Center

    Chalufour, Ingrid; Worth, Karen

    Young children's curiosity about nature and their need to make sense of the world presents an opportunity to incorporate science as a natural and critical part of children's early learning. This guide, part of a preschool science curriculum, uses an inquiry approach to encourage young naturalists to observe life more closely, build an…

  9. Young Offender Information Sharing Protocol.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Special Education Branch.

    Schools have expressed a need to know the identity and/or circumstances of young offenders in order to address school safety and security issues, and to provide a collaborative and coordinated case management approach for the rehabilitation of the young person. A framework for the exchange of information between youth justice and school officials…

  10. Young People and Contemporary Art

    ERIC Educational Resources Information Center

    Illeris, Helene

    2005-01-01

    In this article empirical examples are used to connect theories about young people, contemporary art forms and learning. The first part of the article introduces the new forms of consciousness which, according to the youth researchers Birgitte Simonsen and Thomas Ziehe, characterize young people of today. In the second part, the qualities of…

  11. Young Children's Understanding of Denial

    ERIC Educational Resources Information Center

    Austin, Keith; Theakston, Anna; Lieven, Elena; Tomasello, Michael

    2014-01-01

    Although a fair amount is known about young children's production of negation, little is known about their comprehension. Here, we focus on arguably the most complex basic form, denial, and how young children understand denial, when it is expressed in response to a question with gesture, single word, or sentence. One hundred twenty-six children in…

  12. Environmental Design for Young Children.

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.

    1977-01-01

    The special issue of the journal, Children in Contemporary Society, contains 17 brief articles on environmental design for young handicapped and normal children. Articles have the following titles: "Introduction", "Environmental Design and Architecture", "Why Is Environmental Design Important to Young Children", "Children's Hospital National…

  13. Environmental Design for Young Children.

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.

    1977-01-01

    The special issue of the journal, Children in Contemporary Society, contains 17 brief articles on environmental design for young handicapped and normal children. Articles have the following titles: "Introduction", "Environmental Design and Architecture", "Why Is Environmental Design Important to Young Children", "Children's Hospital National…

  14. Injuries to the Young Athlete.

    ERIC Educational Resources Information Center

    Sandusky, Jane C.

    A review of literature on the incidence and nature of injuries to young athletes is presented on the topics of: (1) physiological characteristics of preadolescents, adolescents, and young adults; (2) musculo-skeletal changes in the growing athlete; (3) epiphyseal injuries and their potential for resulting in temporary or permanent impairment; (4)…

  15. Effective Communication with Young People

    ERIC Educational Resources Information Center

    Shanahan, Patrick; Elliott, David

    2009-01-01

    The Australian Government established the Office for Youth (the Office) in September 2008 in an effort to engage with the young people of Australia. The Office will work with other government agencies to help young people reach their full potential; make effective transitions to adulthood as they continue to learn, start work, make decisions that…

  16. Self-harm in young offenders.

    PubMed

    Borschmann, Rohan; Coffey, Carolyn; Moran, Paul; Hearps, Stephen; Degenhardt, Louisa; Kinner, Stuart A; Patton, George

    2014-12-01

    The prevalence and correlates of self-harm and suicidal behavior in 515 young offenders (mean age 17.3 years, SD = 1.7) serving community-based orders (CBOs; n = 242) or custodial sentences (n = 273) in Victoria, Australia, are described. Results from structured interviews showed that 83 (16.1%) participants reported self-harming in the previous 6 months, and this was more common among those serving custodial sentences than those serving CBOs (19.4% vs. 12.4%; OR 3.10, 95% CI: 1.74-5.55). Multiple incidents were more common in females and 24% (95% CI: 19-39) of participants who had self-harmed reported having done so with suicidal intent. Self-harm was associated with recent bullying victimization, expulsion from school, past year violent victimization, cannabis dependence, and risk-taking behavior in the preceding year. The epidemiological profile of self-harm in this population appears to be distinct from that seen in the general population. Young offenders who self-harm are a vulnerable group with high rates of psychiatric morbidity, substance misuse problems, and social risk factors. They may benefit from targeted psychological interventions designed specifically to address impulsivity, delivered both within-and during the transition from-the youth justice system.

  17. Young Star HD 141569

    NASA Image and Video Library

    2017-01-30

    This image shows the dusty disk of planetary material surrounding the young star HD 141569, located 380 light-years away from Earth. It was taken using the vortex coronagraph on the W.M. Keck Observatory. The vortex suppressed light from the star in the center, revealing light from the innermost ring of planetary material around the star (blue). The disk around the star, made of olivine particles, extends from 23 to 70 astronomical units from the star. By comparison, Uranus is over 19 astronomical units from our sun, and Neptune about 30 astronomical units. One astronomical unit is the distance between Earth and our sun. http://photojournal.jpl.nasa.gov/catalog/PIA21090

  18. Osteosarcoma in young children.

    PubMed

    Kozakewich, H; Perez-Atayde, A R; Goorin, A M; Wilkinson, R H; Gebhardt, M C; Vawter, G F

    1991-02-01

    The clinicopathologic features of osteosarcoma in 12 children younger than 16 years of age treated at The Children's Hospital and Dana-Farber Cancer Institute, Boston, during a 70-year time period are presented. Only one of six children treated before 1972 is a long-term survivor. Four of six children (67%) treated after 1972 are disease-free with an average follow-up of 8.8 years. The year 1972 marked the onset of use of effective chemotherapy in osteosarcoma, namely, high-dose methotrexate and leucovorin rescue. It would appear that the pathologic features and behavior of osteosarcoma in young children is similar to that of osteosarcoma in older children and adolescents. A combination of complete (wide) surgical resection or amputation and aggressive chemotherapy offers the best chance of long-term survival.

  19. Young-Onset Dementia

    PubMed Central

    Kuruppu, Dulanji K; Matthews, Brandy R

    2014-01-01

    Young-onset dementia (YOD) is an neurological syndrome that affects behavior and cognition of patients younger than 65 years of age. Although frequently misdiagnosed, a systematic approach, reliant upon attainment of detailed medical history, collateral history from an informant, neuropsychological testing, laboratory studies, and neuroimaging, may facilitate earlier and more accurate diagnosis with subsequent intervention. The differential diagnosis of YOD is extensive and includes early-onset forms of adult neurodegenerative conditions including Alzheimer's disease, vascular dementia, frontotemporal dementia, Lewy body dementias, Huntington's disease, and prion disease. Late-onset forms of childhood neurodegenerative conditions may also present as YOD and include mitochondrial disorders, lysosomal storage disorders, and leukodystrophies. Potentially reversible etiologies including inflammatory disorders, infectious diseases, toxic/metabolic abnormalities, transient epileptic amnesia, obstructive sleep apnea, and normal pressure hydrocephalus also represent important differential diagnostic considerations in YOD. This review will present etiologies, diagnostic strategies, and options for management of YOD with comprehensive summary tables for clinical reference. PMID:24234358

  20. Compact Hermitian Young projection operators

    NASA Astrophysics Data System (ADS)

    Alcock-Zeilinger, J.; Weigert, H.

    2017-05-01

    In this paper, we describe a compact and practical algorithm to construct Hermitian Young projection operators for irreducible representations of the special unitary group 𝖲𝖴 (N ) and discuss why ordinary non-Hermitian Young projection operators are unsuitable for physics applications. The proof of this construction algorithm uses the iterative method described by Keppeler and Sjödahl [J. Math. Phys. 55, 021702 (2014)]. We further show that Hermitian Young projection operators share desirable properties with Young tableaux, namely, a nested hierarchy when "adding a particle." We close by exhibiting the enormous advantage of the Hermitian Young projection operators constructed in this paper over those given by Keppeler and Sjödahl.