An Evaluation of Deficits in Semantic Cuing, Proactive and Retroactive Interference as Early Features of Alzheimer’s disease

PubMed Central

Crocco, Elizabeth; Curiel, Rosie E.; Acevedo, Amarilis; Czaja, Sara J.; Loewenstein, David A.

2015-01-01

OBJECTIVE To determine the degree to which susceptibility to different types of semantic interference may reflect the earliest manifestations of early Alzheimer disease (AD) beyond the effects of global memory impairment. METHODS Normal elderly (NE) subjects (n= 47), subjects with amnestic mild cognitive impairment (aMCI: n=34) and 40 subjects with probable AD were evaluated using a unique cued recall paradigm that allowed for an evaluation of both proactive and retroactive interference effects while controlling for global memory impairment (LASSI-L procedure). RESULTS Controlling for overall memory impairment, aMCI subjects had much greater proactive and retroactive interference effects than NE subjects. LASSI-L indices of learning using cued recall evidenced high levels of sensitivity and specificity with an overall correct classification rate of 90%. These provided better discrimination than traditional neuropsychological measures of memory function. CONCLUSION The LASSI-L paradigm is unique and unlike other assessments of memory in that items presented for cued recall are explicitly presented, and semantic interference and cuing effects can be assessed while controlling for initial level of memory impairment. This represents a powerful procedure allowing the participant to serve as his or her own control. The high levels of discrimination between subjects with aMCI and normal cognition that exceeded traditional neuropsychological measures makes the LASSI-L worthy of further research in the detection of early AD. PMID:23768680

Disjunction and conjunction fallacies in episodic memory.

PubMed

Nakamura, K; Brainerd, C J

2017-09-01

It has recently been found that episodic memory displays analogues of the well-known disjunction and conjunction fallacies of probability judgement. The aim of the present research was, for the first time, to study these memory fallacies together under the same conditions, and test theoretical predictions about the reasons for each. The focus was on predictions about the influence of semantic gist, target versus context recollection, and proactive versus retroactive interference. Disjunction and conjunction fallacies increased in conditions in which subjects were able to form semantic connections among list words. In addition, disjunction fallacies were increased by manipulations that minimised proactive interference, whereas conjunction fallacies were increased by manipulations that minimised retroactive interference. That pattern suggests that disjunction fallacies are more dependent on target recollection, whereas conjunction fallacies are more dependent on context recollection.

An evaluation of deficits in semantic cueing and proactive and retroactive interference as early features of Alzheimer's disease.

PubMed

Crocco, Elizabeth; Curiel, Rosie E; Acevedo, Amarilis; Czaja, Sara J; Loewenstein, David A

2014-09-01

To determine the degree to which susceptibility to different types of semantic interference may reflect the initial manifestations of early Alzheimer's disease (AD) beyond the effects of global memory impairment. Normal elderly (NE) subjects (n = 47), subjects with amnestic mild cognitive impairment (aMCI; n = 34), and subjects with probable AD (n = 40) were evaluated by using a unique cued recall paradigm that allowed for evaluation of both proactive and retroactive interference effects while controlling for global memory impairment (i.e., Loewenstein-Acevedo Scales of Semantic Interference and Learning [LASSI-L] procedure). Controlling for overall memory impairment, aMCI subjects had much greater proactive and retroactive interference effects than NE subjects. LASSI-L indices of learning by using cued recall revealed high levels of sensitivity and specificity, with an overall correct classification rate of 90%. These measures provided better discrimination than traditional neuropsychological measures of memory function. The LASSI-L paradigm is unique and unlike other assessments of memory in that items posed for cued recall are explicitly presented, and semantic interference and cueing effects can be assessed while controlling for initial level of memory impairment. This is a powerful procedure that allows the participant to serve as his or her own control. The high levels of discrimination between subjects with aMCI and normal cognition that exceeded traditional neuropsychological measures makes the LASSI-L worthy of further research in the detection of early AD. Copyright © 2014 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Increased sensitivity to proactive and retroactive interference in amnestic mild cognitive impairment: new insights.

PubMed

Hanseeuw, Bernard J; Seron, Xavier; Ivanoiu, Adrian

2012-10-01

Increased sensitivity to proactive (PI) and retroactive (RI) interference has been observed in amnestic mild cognitive impairment (aMCI). PI and RI are often explained as being the result of a response competition mechanism. However, patients with aMCI are supposed to suffer mostly from encoding deficits. We hypothesized that in aMCI interference may occur at encoding and not only at the retrieval stage. We developed an original paradigm enabling PI and RI to be tested with and without response competitors. Eighteen young controls (YC), 16 elderly controls (EC) and 15 aMCI participated in the study. The YC and EC groups presented interference effects only in conditions that included a direct response competitor. In contrast, aMCI had interference effects in all conditions including the one without response competitor. Increased sensitivity to interference in aMCI appears to occur at the encoding/consolidation stage and not only at the retrieval stage, as is the case in healthy subjects. This result is discussed in the context of the associative encoding deficits characterizing aMCI. Copyright © 2012 Elsevier Inc. All rights reserved.

Rapid Eye Movement and Non-Rapid Eye Movement Sleep Contributions in Memory Consolidation and Resistance to Retroactive Interference for Verbal Material

PubMed Central

Deliens, Gaétane; Leproult, Rachel; Neu, Daniel; Peigneux, Philippe

2013-01-01

Study Objectives: To test the hypothesis that rapid eye movement (REM) sleep contributes to the consolidation of new memories, whereas non-rapid eye movement (NREM) sleep contributes to the prevention of retroactive interference. Design: Randomized, crossover study. Setting: Two sessions of either a morning nap or wakefulness. Participants: Twenty-five healthy young adults. Interventions: Declarative learning of word pairs followed by a nap or a wake interval, then learning of interfering word pairs and delayed recall of list A. Measurements and Results: After a restricted night (24:00-06:00), participants learned a list of word pairs (list A). They were then required to either take a nap or stay awake during 45 min, after which they learned a second list of word pairs (list B) and then had to recall list A. Fifty percent of word pairs in list B shared the first word with list A, resulting in interference. Ten subjects exhibited REM sleep whereas 13 subjects exhibited NREM stage 3 (N3) sleep. An interference effect was observed in the nap but not in the wake condition. In post-learning naps, N3 sleep was associated with a reduced interference effect, which was not the case for REM sleep. Moreover, participants exhibiting N3 sleep in the post-learning nap condition also showed a reduced interference effect in the wake condition, suggesting a higher protection ability against interference. Conclusion: Our results partly support the hypothesis that non-rapid eye movement sleep contributes in protecting novel memories against interference. However, rapid eye movement sleep-related consolidation is not evidenced. Citation: Deliens G; Leproult R; Neu D; Peigneux P. Rapid eye movement and non-rapid eye movement sleep contributions in memory consolidation and resistance to retroactive interference for verbal material. SLEEP 2013;36(12):1875-1883. PMID:24293762

REM sleep rescues learning from interference

PubMed Central

McDevitt, Elizabeth A.; Duggan, Katherine A.; Mednick, Sara C.

2015-01-01

Classical human memory studies investigating the acquisition of temporally-linked events have found that the memories for two events will interfere with each other and cause forgetting (i.e., interference; Wixted, 2004). Importantly, sleep helps consolidate memories and protect them from subsequent interference (Ellenbogen, Hulbert, Stickgold, Dinges, & Thompson-Schill, 2006). We asked whether sleep can also repair memories that have already been damaged by interference. Using a perceptual learning paradigm, we induced interference either before or after a consolidation period. We varied brain states during consolidation by comparing active wake, quiet wake, and naps with either non-rapid eye movement sleep (NREM), or both NREM and REM sleep. When interference occurred after consolidation, sleep and wake both produced learning. However, interference prior to consolidation impaired memory, with retroactive interference showing more disruption than proactive interference. Sleep rescued learning damaged by interference. Critically, only naps that contained REM sleep were able to rescue learning that was highly disrupted by retroactive interference. Furthermore, the magnitude of rescued learning was correlated with the amount of REM sleep. We demonstrate the first evidence of a process by which the brain can rescue and consolidate memories damaged by interference, and that this process requires REM sleep. We explain these results within a theoretical model that considers how interference during encoding interacts with consolidation processes to predict which memories are retained or lost. PMID:25498222

The Auditory Verbal Learning Test (Rey AVLT): An Arabic Version

ERIC Educational Resources Information Center

Sharoni, Varda; Natur, Nazeh

2014-01-01

The goals of this study were to adapt the Rey Auditory Verbal Learning Test (AVLT) into Arabic, to compare recall functioning among age groups (6:0 to 17:11), and to compare gender differences on various memory dimensions (immediate and delayed recall, learning rate, recognition, proactive interferences, and retroactive interferences). This…

Questioning the rule of thumb: can verbal tasks be administered during the CVLT-II delay interval?

PubMed

Williams, Bethany R; Donovick, Peter J

2008-09-01

In the manual for the California Verbal Learning Test - II (CVLT-II), the authors suggest that nonverbal, rather than verbal, tasks be administered during the delay interval between administrations of the Short- and Long-Delay Recall trials of this test. They contend that this method minimizes the retroactive interference produced by intervening tasks. The purpose of the current study was to compare the extent to which verbal and nonverbal intervening tasks produce retroactive interference on CVLT-II List A recall following the long-delay. Participants in the present study were 120 undergraduate students. All participants completed the CVLT-II, and were randomly assigned to a group in which they were administered either a verbal (WAIS-III Vocabulary or Peabody Picture Vocabulary Test - IIIB) or nonverbal (Raven's Standard Progressive Matrices or WAIS-III Block Design) intervening task during the long-delay interval of the CVLT-II. Statistical analyses revealed that regardless of the type of intervening task given, participants in all groups recalled the same number of words and produced a similar number of intrusions during the CVLT-II recall trials. This indicates that not all verbal tasks produce retroactive effects beyond those produced by nonverbal tasks.

Learning during the Newborn's First Meal: Special Resistance to Retroactive Interference

ERIC Educational Resources Information Center

Cheslock, Sarah J. Ferdinand; Sanders, Sarah K.; Spear, Norman E.

2004-01-01

At their first postnatal meal, 3-hour-old rats learned an association between an odor and a sweet or bitter taste. Retention after a long interval or after associative interference was compared to that of 1-day-old rats. Despite equivalent and negligible effect of the long retention interval, contrary to infantile amnesia, newborns differed…

Retro-Active Emotion: Do Negative Emotional Stimuli Disrupt Consolidation in Working Memory?

PubMed

Kandemir, Güven; Akyürek, Elkan G; Nieuwenstein, Mark R

2017-01-01

While many studies have shown that a task-irrelevant emotionally arousing stimulus can interfere with the processing of a shortly following target, it remains unclear whether an emotional stimulus can also retro-actively interrupt the ongoing processing of an earlier target. In two experiments, we examined whether the presentation of a negative emotionally arousing picture can disrupt working memory consolidation of a preceding visual target. In both experiments, the effects of negative emotional pictures were compared with the effects of neutral pictures. In Experiment 1, the pictures were entirely task-irrelevant whereas in Experiment 2 the pictures were associated with a 2-alternative forced choice task that required participants to respond to the color of a frame surrounding the pictures. The results showed that the appearance of the pictures did not interfere with target consolidation when the pictures were task-irrelevant, whereas such interference was observed when the pictures were associated with a 2-AFC task. Most importantly, however, the results showed no effects of whether the picture had neutral or emotional content. Implications for further research are discussed.

Rapid eye movement and non-rapid eye movement sleep contributions in memory consolidation and resistance to retroactive interference for verbal material.

PubMed

Deliens, Gaétane; Leproult, Rachel; Neu, Daniel; Peigneux, Philippe

2013-12-01

To test the hypothesis that rapid eye movement (REM) sleep contributes to the consolidation of new memories, whereas non-rapid eye movement (NREM) sleep contributes to the prevention of retroactive interference. Randomized, crossover study. Two sessions of either a morning nap or wakefulness. Twenty-five healthy young adults. Declarative learning of word pairs followed by a nap or a wake interval, then learning of interfering word pairs and delayed recall of list A. After a restricted night (24:00-06:00), participants learned a list of word pairs (list A). They were then required to either take a nap or stay awake during 45 min, after which they learned a second list of word pairs (list B) and then had to recall list A. Fifty percent of word pairs in list B shared the first word with list A, resulting in interference. Ten subjects exhibited REM sleep whereas 13 subjects exhibited NREM stage 3 (N3) sleep. An interference effect was observed in the nap but not in the wake condition. In post-learning naps, N3 sleep was associated with a reduced interference effect, which was not the case for REM sleep. Moreover, participants exhibiting N3 sleep in the post-learning nap condition also showed a reduced interference effect in the wake condition, suggesting a higher protection ability against interference. Our results partly support the hypothesis that non-rapid eye movement sleep contributes in protecting novel memories against interference. However, rapid eye movement sleep-related consolidation is not evidenced.

Sleep Shelters Verbal Memory from Different Kinds of Interference

PubMed Central

Sheth, Bhavin R.; Varghese, Reni; Truong, Thuy

2012-01-01

Study Objectives: Studies have shown that sleep shelters old verbal memories from associative interference arising from new, more recently acquired memories. Our objective is to extend the forms of interference for which sleep provides a sheltering benefit to non-associative and prospective interference, and to examine experimental conditions and memory strengths for which sleep before or after learning particularly affects verbal memory consolidation. Design: Acquiring paired word associates, retention across intervening sleep and wake, training on new, interfering word associates, and test recall of both sets. Setting: University laboratory. Participants: Healthy volunteers. Interventions: N/A. Measurements and Results: Comparing recall before and after intervening periods of sleep versus wake, we found that: (i) Sleep preferentially shields weakly encoded verbal memories from retroactive interference. (ii) Sleep immediately following learning helps shelter memory from associative and non-associative forms of retroactive interference. (iii) Sleep protects new verbal memories from prospective interference. (iv) Word associations acquired for the first time in the evening after a day spent in the wake state are encoded more strongly than word associations acquired in the morning following a night of sleep. Conclusions: The findings extend the known sleep protection from interference to non-associative as well as prospective interference, and limit the protection to weakly encoded word associations. Combined, our results suggest that sleep immediately after verbal learning isolates newly formed memory traces and renders them inaccessible, except by specific contextual cues. Memory isolation in sleep is a passive mechanism that can reasonably account for several experimental findings. Citation: Sheth BR; Varghese R; Truong T. Sleep shelters verbal memory from different kinds of interference. SLEEP 2012;35(7):985-996. PMID:22754045

I saw where you have been--The topography of human demonstration affects dogs' search patterns and perseverative errors.

PubMed

Péter, András; Topál, József; Miklósi, Ádám; Pongrácz, Péter

2016-04-01

Performance in object search tasks is not only influenced by the subjects' object permanence ability. For example, ostensive cues of the human manipulating the target markedly affect dogs' choices. However, the interference between the target's location and the spatial cues of the human hiding the object is still unknown. In a five-location visible displacement task, the experimental groups differed in the hiding route of the experimenter. In the 'direct' condition he moved straight towards the actual location, hid the object and returned to the dog. In the 'indirect' conditions, he additionally walked behind each screen before returning. The two 'indirect' conditions differed from each other in that the human either visited the previously baited locations before (proactive interference) or after (retroactive interference) hiding the object. In the 'indirect' groups, dogs' performance was significantly lower than in the 'direct' group, demonstrating that for dogs, in an ostensive context, spatial cues of the hider are as important as the observed location of the target. Based on their incorrect choices, dogs were most attracted to the previously baited locations that the human visited after hiding the object in the actual trial. This underlines the importance of retroactive interference in multiple choice tasks. Copyright © 2016 Elsevier B.V. All rights reserved.

Retrieval Practice Fails to Insulate Episodic Memories against Interference after Stroke.

PubMed

Pastötter, Bernhard; Eberle, Hanna; Aue, Ingo; Bäuml, Karl-Heinz T

2017-01-01

Recent work in cognitive psychology showed that retrieval practice of previously studied information can insulate this information against retroactive interference from subsequently studied other information in healthy individuals. The present study examined whether this beneficial effect of interference reduction is also present in patients with stroke. Twenty-two patients with stroke, 4.6 months post injury on average, and 22 healthy controls participated in the experiment. In each of two experimental sessions, participants first studied a list of items (list 1) and then underwent a practice phase in which the list 1 items were either restudied or retrieval practiced. Participants then either studied a second list of items (list 2) or fulfilled an unrelated distractor task. Recall of the two lists' items was assessed in a final criterion test. Results showed that, in healthy controls, additional study of list 2 items impaired final recall of list 1 items in the restudy condition but not in the retrieval practice condition. In contrast, in patients with stroke, list 2 learning impaired final list 1 recall in both conditions. The results indicate that retrieval practice insulated the tested information against retroactive interference in healthy controls, but failed to do so in patients with stroke. Possible implications of the findings for the understanding of long-term memory impairment after stroke are discussed.

Memory consolidation and expression of object recognition are susceptible to retroactive interference.

PubMed

Villar, María Eugenia; Martinez, María Cecilia; Lopes da Cunha, Pamela; Ballarini, Fabricio; Viola, Haydee

2017-02-01

With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3h after training was not affected, whereas the OR-LTM measured at 24h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. Copyright © 2016 Elsevier Inc. All rights reserved.

Proactive and retroactive transfer of middle age adults in a sequential motor learning task.

PubMed

Verneau, Marion; van der Kamp, John; Savelsbergh, Geert J P; de Looze, Michiel P

2015-03-01

We assessed the effects of aging in the transfer of motor learning in a sequential manual assembly task that is representative for real working conditions. On two different days, young (18-30 years) and middle-aged adults (50-65 years) practiced to build two products that consisted of the same six components but which had to be assembled in a partly different order. Assembly accuracy and movement time during tests, which were performed before and after the practice sessions, were compared to determine proactive and retroactive transfer. The results showed proactive facilitation (i.e., benefits from having learned the first product on learning the second one) in terms of an overall shortening of movement time in both age-groups. In addition, only the middle-aged adults were found to show sequence-specific proactive facilitation, in which the shortening of movement time was limited to components that had the same the order in the two products. Most likely, however, the sequence-specific transfer was an epiphenomenon of the comparatively low rate of learning among the middle-aged adults. The results, however, did reveal genuine differences between the groups for retroactive transfer (i.e., effects from learning the second product on performance of the first). Middle-aged adults tended to show more pronounced retroactive interference in terms of a general decrease in accuracy, while younger adults showed sequence-specific retroactive facilitation (i.e., shortening of movement times for components that had the same order in the two products), but only when they were fully accurate. Together this suggests that in the learning of sequential motor tasks the effects of age are more marked for retroactive transfer than for proactive transfer. Copyright © 2015 Elsevier B.V. All rights reserved.

Short-Term Memory; An Annotated Bibliography.

ERIC Educational Resources Information Center

Reynolds, Donald; Rosenblatt, Richard D.

This annotated bibliography on memory is divided into 12 areas: information theory; proactive and retroactive interference and interpolated activities; set, subject strategies, and coding techniques; paired associate studies; simultaneous listening and memory span studies; rate and mode of stimulus presentation; rate and order of recall, and…

The Effects of Within-Sequence Acoustic Similarity on the Short-Term Retention of Consonants and Words

ERIC Educational Resources Information Center

Marcer, D.; And Others

1977-01-01

Compares the rates of forgetting of five-item sequences of acoustically similar and dissimilar consonants and words in the absence of proactive and retroactive interference in order to test whether within sequence similarity rather than stimulus length would have a greater influence on retention. (Author/RK)

Forgetting due to retroactive interference: A fusion of Müller and Pilzecker's (1900) early insights into everyday forgetting and recent research on anterograde amnesia

PubMed Central

Dewar, Michaela T.; Cowan, Nelson; Della Sala, Sergio

2008-01-01

Ebbinghaus' seminal work suggested that forgetting occurred as a function of time. However, it raised a number of fundamental theoretical issues that still have not been resolved in the literature. Müller and Pilzecker (1900) addressed some of these issues in a remarkable manner but their observations have been mostly ignored in recent years. Müller and Pilzecker showed that the materials and the task that intervene between presentation and recall may interfere with the to-be-remembered items, and they named this phenomenon “retroactive interference” (RI). They further asked whether there is a type of RI that is based only on distraction, and not on the similarity between the memoranda and the interfering stimuli. Their findings, and our follow up research in healthy volunteers and amnesiacs, confirm that forgetting can be induced by any subsequent mentally effortful interpolated task, irrespective of its content; the interpolated ‘interfering’ material does not have to be similar to the to-be-remembered stimuli. PMID:17715797

Another look at retroactive and proactive interference: a quantitative analysis of conversion processes.

PubMed

Blank, Hartmut

2005-02-01

Traditionally, the causes of interference phenomena were sought in "real" or "hard" memory processes such as unlearning, response competition, or inhibition, which serve to reduce the accessibility of target items. I propose an alternative approach which does not deny the influence of such processes but highlights a second, equally important, source of interference-the conversion (Tulving, 1983) of accessible memory information into memory performance. Conversion is conceived as a problem-solving-like activity in which the rememberer tries to find solutions to a memory task. Conversion-based interference effects are traced to different conversion processes in the experimental and control conditions of interference designs. I present a simple theoretical model that quantitatively predicts the resulting amount of interference. In two paired-associate learning experiments using two different types of memory tests, these predictions were corroborated. Relations of the present approach to traditional accounts of interference phenomena and implications for eyewitness testimony are discussed.

Associative Interference and Recognition Memory.

ERIC Educational Resources Information Center

Underwood, Benton J.; And Others

Three experiments tested the generality of the conclusion that associative unlearning is minimal in the A-B, A-D paradigm. In Experiment 1, single-trial study of A-D, following single-trial study of A-B, did not produce retroactive inhibition in the recognition of A-B. In Experiment 2, A-B was acquired by associative matching. The interpolated…

A Mental Practice Superiority Effect: Less Retroactive Interference and More Transfer than Physical Practice

ERIC Educational Resources Information Center

Wohldmann, Erica L.; Healy, Alice F.; Bourne, Lyle E., Jr.

2008-01-01

Two experiments explored the benefits to retention and transfer conferred by mental practice. During familiarization, participants typed 4-digit numbers and took an immediate typing test on both old and new numbers. Participants then typed old 4-digit numbers, either physically or mentally, with either a different response configuration or the…

Interference effects on commonly used memory tasks.

PubMed

Brophy, Linda M; Jackson, Martin; Crowe, Simon F

2009-02-01

This paper reports two studies which investigated the effect of interference on delayed recall scores of the WMS-III and other commonly used memory measures. In Study 1, participants completed the immediate and delayed components of the WMS-III, with or without the introduction of conceptually similar memory tasks between the recall trials. In Study 2, this order of administration was reversed, with the WMS-III subtests used as the interference items. The results indicated that the introduction of interference items during the delay negatively affected delayed recall performance on almost all sub-tests. In addition, equal effects of proactive and retroactive interference were demonstrated. These findings raise concerns regarding the standardization process for memory tasks and highlight the need to consider interference effects in clinical practice, and stand as a caution in the use of memory-related materials during the delay interval in memory testing.

Effects of Context Change upon Retrieval of First and Second-Learned Information in Human Predictive Learning

ERIC Educational Resources Information Center

Rosas, Juan M.; Garcia-Gutierrez, Ana; Callejas-Aguilera, Jose E.

2006-01-01

Two experiments were conducted to evaluate the context switch effect upon retrieval of the information about a cue-outcome relationship in human predictive learning. The results replicated the well-known effect of renewal of the cue-outcome relationship due to a context change after a retroactive interference treatment, as much as the null effect…

Developmental differences in the impact of contextual factors on susceptibility to retroactive interference.

PubMed

Levy-Gigi, Einat; Vakil, Eli

2010-01-01

The influence of contextual similarity on children's recognition memory performance was examined using a retroactive interference paradigm. In the study, 9- and 12-year-olds were randomly assigned to one of two contextual conditions. In both conditions, target and interfering information were presented in distinctive contexts by using different modalities (pictures and words, respectively). However, in one condition the test was presented in the same context as the target information (picture-word-picture [PWP] condition), whereas in the other condition the test was presented in the same context as the interfering information (picture-word-word [PWW] condition). Performance in these conditions was compared with performance in a noninterference control condition (picture-word [P-W]). As predicted, overall recognition performance in the PWP condition was significantly better than in the PWW condition. However, whereas in the PWP condition there was no age difference in performance, in the PWW condition the 12-year-old group produced significantly more hits and fewer false alarms than the 9-year-old group. The theoretical implications of the results are discussed in reference to the effortful engagement of developmentally dependent executive control processes.

The dual effect of context on memory of related and unrelated themes: discrimination at encoding and cue at retrieval.

PubMed

Levy-Gigi, Einat; Vakil, Eli

2012-01-01

The influence of contextual factors on encoding and retrieval in recognition memory was investigated using a retroactive interference paradigm. Participants were randomly assigned to four context conditions constructed by manipulating types of presentation modality (pictures vs words) for study, interference, and test stages, respectively (ABA, ABB, AAA, & AAB). In Experiment 1 we presented unrelated items in the study and interference stages, while in Experiment 2 each stage contained items from the same semantic category. The results demonstrate a dual role for context in memory processes-at encoding as well as at retrieval. In Experiment 1 there is a hierarchical order between the four context conditions, depending on both target-test and target-interference contextual similarity. Adding a categorical context in Experiment 2 helped to specify each list and therefore better distinguish between target and interferer information, and in some conditions compensated for their perceptual similarity.

Cue-dependent interference in comprehension

PubMed Central

Van Dyke, Julie A.

2011-01-01

The role of interference as a primary determinant of forgetting in memory has long been accepted, however its role as a contributor to poor comprehension is just beginning to be understood. The current paper reports two studies, in which speed-accuracy tradeoff and eye-tracking methodologies were used with the same materials to provide converging evidence for the role of syntactic and semantic cues as mediators of both proactive (PI) and retroactive interference (RI) during comprehension. Consistent with previous work (e.g., Van Dyke & Lewis, 2003), we found that syntactic constraints at the retrieval site are among the cues that drive retrieval in comprehension, and that these constraints effectively limit interference from potential distractors with semantic/pragmatic properties in common with the target constituent. The data are discussed in terms of a cue-overload account, in which interference both arises from and is mediated through a direct-access retrieval mechanism that utilizes a linear, weighted cue-combinatoric scheme. PMID:21927535

Beyond a mask and against the bottleneck: retroactive dual-task interference during working memory consolidation of a masked visual target.

PubMed

Nieuwenstein, Mark; Wyble, Brad

2014-06-01

While studies on visual memory commonly assume that the consolidation of a visual stimulus into working memory is interrupted by a trailing mask, studies on dual-task interference suggest that the consolidation of a stimulus can continue for several hundred milliseconds after a mask. As a result, estimates of the time course of working memory consolidation differ more than an order of magnitude. Here, we contrasted these opposing views by examining if and for how long the processing of a masked display of visual stimuli can be disturbed by a trailing 2-alternative forced choice task (2-AFC; a color discrimination task or a visual or auditory parity judgment task). The results showed that the presence of the 2-AFC task produced a pronounced retroactive interference effect that dissipated across stimulus onset asynchronies of 250-1,000 ms, indicating that the processing elicited by the 2-AFC task interfered with the gradual consolidation of the earlier shown stimuli. Furthermore, this interference effect occurred regardless of whether the to-be-remembered stimuli comprised a string of letters or an unfamiliar complex visual shape, and it occurred regardless of whether these stimuli were masked. Conversely, the interference effect was reduced when the memory load for the 1st task was reduced, or when the 2nd task was a color detection task that did not require decision making. Taken together, these findings show that the formation of a durable and consciously accessible working memory trace for a briefly shown visual stimulus can be disturbed by a trailing 2-AFC task for up to several hundred milliseconds after the stimulus has been masked. By implication, the current findings challenge the common view that working memory consolidation involves an immutable central processing bottleneck, and they also make clear that consolidation does not stop when a stimulus is masked. PsycINFO Database Record (c) 2014 APA, all rights reserved.

29 CFR 778.303 - Retroactive pay increases.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Retroactive pay increases. 778.303 Section 778.303 Labor... Additional Pay for Past Period § 778.303 Retroactive pay increases. Where a retroactive pay increase is... regular rate of pay of the employees for the period of its retroactivity. Thus, if an employee is awarded...

When Learning Disturbs Memory – Temporal Profile of Retroactive Interference of Learning on Memory Formation

PubMed Central

Sosic-Vasic, Zrinka; Hille, Katrin; Kröner, Julia; Spitzer, Manfred; Kornmeier, Jürgen

2018-01-01

Introduction: Consolidation is defined as the time necessary for memory stabilization after learning. In the present study we focused on effects of interference during the first 12 consolidation minutes after learning. Participants had to learn a set of German – Japanese word pairs in an initial learning task and a different set of German – Japanese word pairs in a subsequent interference task. The interference task started in different experimental conditions at different time points (0, 3, 6, and 9 min) after the learning task and was followed by subsequent cued recall tests. In a control experiment the interference periods were replaced by rest periods without any interference. Results: The interference task decreased memory performance by up to 20%, with negative effects at all interference time points and large variability between participants concerning both the time point and the size of maximal interference. Further, fast learners seem to be more affected by interference than slow learners. Discussion: Our results indicate that the first 12 min after learning are highly important for memory consolidation, without a general pattern concerning the precise time point of maximal interference across individuals. This finding raises doubts about the generalized learning recipes and calls for individuality of learning schedules. PMID:29503621

75 FR 21505 - Retroactive Stop Loss Special Pay Compensation; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... 0790-AI59] Retroactive Stop Loss Special Pay Compensation; Correction AGENCY: Office of the Under... Retroactive Stop Loss Special Pay Compensation that was authorized and appropriated in the Supplemental... the Act. The change of eligibility for Retroactive Stop Loss [[Page 21506

14 CFR 25.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Special retroactive requirements. 25.2... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES General § 25.2 Special retroactive requirements. The following special retroactive requirements are applicable to an airplane for which the regulations...

Adult Age Differences in Production and Monitoring in Dual-List Free Recall

PubMed Central

Wahlheim, Christopher N.; Ball, B. Hunter; Richmond, Lauren L.

2017-01-01

The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall. Younger and older adults studied two lists of unrelated words and were instructed to recall from List 1, List 2, or List 1 and List 2. An externalized free recall (EFR) procedure required participants to: 1) report all responses that came to mind while recalling from specific lists, 2) classify responses as correct or incorrect, and 3) provide confidence judgments for their accuracy classifications. Relative to younger adults, older adults showed a monitoring deficit by misclassifying proportionally more responses and discriminating more poorly between correct and incorrect responses in their confidence judgments. This deficit was especially pronounced under conditions of retroactive interference that occurred when participants recalled from List 1 only. A comparison of retrieval dynamics for all responses produced and for those that participants were reasonably confident were correct provided information about age differences in preretrieval context reinstatement and postretrieval monitoring of retrieved context. One noteworthy finding was that total production when recalling from List 1 showed that List 2 responses remained more accessible across the first several retrieval attempts for older than younger adults, which indicated a substantial age difference in the ability to reinstate List 1 context. Overall, the present findings provide a nuanced characterization of age differences in the operation of production and monitoring mechanisms under conditions of proactive and retroactive interference that can inform models of free recall. PMID:28206784

Adult age differences in production and monitoring in dual-list free recall.

PubMed

Wahlheim, Christopher N; Ball, B Hunter; Richmond, Lauren L

2017-06-01

The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall. Younger and older adults studied 2 lists of unrelated words and were instructed to recall from List 1, List 2, or List 1 and List 2. An externalized free recall procedure required participants to: (a) report all responses that came to mind while recalling from specific lists, (b) classify responses as correct or incorrect, and (c) provide confidence judgments for their accuracy classifications. Relative to younger adults, older adults showed a monitoring deficit by misclassifying proportionally more responses and discriminating more poorly between correct and incorrect responses in their confidence judgments. This deficit was especially pronounced under conditions of retroactive interference that occurred when participants recalled from List 1 only. A comparison of retrieval dynamics for all responses produced and for those that participants were reasonably confident were correct provided information about age differences in preretrieval context reinstatement and postretrieval monitoring of retrieved context. One noteworthy finding was that total production when recalling from List 1 showed that List 2 responses remained more accessible across the first several retrieval attempts for older than younger adults, which indicated a substantial age difference in the ability to reinstate List 1 context. Overall, the present findings provide a nuanced characterization of age differences in the operation of production and monitoring mechanisms under conditions of proactive and retroactive interference that can inform models of free recall. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Event models and the fan effect.

PubMed

Radvansky, G A; O'Rear, Andrea E; Fisher, Jerry S

2017-08-01

The current study explored the persistence of event model organizations and how this influences the experience of interference during retrieval. People in this study memorized lists of sentences about objects in locations, such as "The potted palm is in the hotel." Previous work has shown that such information can either be stored in separate event models, thereby producing retrieval interference, or integrated into common event models, thereby eliminating retrieval interference. Unlike prior studies, the current work explored the impact of forgetting up to 2 weeks later on this pattern of performance. We explored three possible outcomes across the various retention intervals. First, consistent with research showing that longer delays reduce proactive and retroactive interference, any retrieval interference effects of competing event models could be reduced over time. Second, the binding of information into events models may weaken over time, causing interference effects to emerge when they had previously been absent. Third, and finally, the organization of information into event models could remain stable over long periods of time. The results reported here are most consistent with the last outcome. While there were some minor variations across the various retention intervals, the basic pattern of event model organization remained preserved over the two-week retention period.

Short-term memory loss over time without retroactive stimulus interference.

PubMed

Cowan, Nelson; AuBuchon, Angela M

2008-02-01

A key question in cognitive psychology is whether information in short-term memory is lost as a function of time. Lewandowsky, Duncan, and Brown (2004) argued against that memory loss because forgetting in serial recall occurred to the same extent across serial positions regardless of the rate of recall. However, we believe Lewandowsky et al. (2004) only prevented one of two types of rehearsal; they did not prevent nonarticulatory rehearsal via attention. To prevent articulatory and nonarticulatory rehearsal without introducing interference, we presented unevenly timed stimuli for serial recall and, on some trials, required that the timing of stimuli be reproduced in the response. In those trials only, evidence of memory loss over time emerged. Further research is needed to identify whether this memory loss is decay or lost distinctiveness.

Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study.

PubMed

Loewenstein, David A; Greig, Maria T; Curiel, Rosie; Rodriguez, Rosemarie; Wicklund, Meredith; Barker, Warren W; Hidalgo, Jacqueline; Rosado, Marian; Duara, Ranjan

2015-12-01

To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology. Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

REM Sleep Enhancement of Probabilistic Classification Learning is Sensitive to Subsequent Interference

PubMed Central

Barsky, Murray M.; Tucker, Matthew A.; Stickgold, Robert

2015-01-01

During wakefulness the brain creates meaningful relationships between disparate stimuli in ways that escape conscious awareness. Processes active during sleep can strengthen these relationships, leading to more adaptive use of those stimuli when encountered during subsequent wake. Performance on the weather prediction task (WPT), a well-studied measure of implicit probabilistic learning, has been shown to improve significantly following a night of sleep, with stronger initial learning predicting more nocturnal REM sleep. We investigated this relationship further, studying the effect on WPT performance of a daytime nap containing REM sleep. We also added an interference condition after the nap/wake period as an additional probe of memory strength. Our results show that a nap significantly boosts WPT performance, and that this improvement is correlated with the amount of REM sleep obtained during the nap. When interference training is introduced following the nap, however, this REM-sleep benefit vanishes. In contrast, following an equal period of wake, performance is both unchanged from training and unaffected by interference training. Thus, while the true probabilistic relationships between WPT stimuli are strengthened by sleep, these changes are selectively susceptible to the destructive effects of retroactive interference, at least in the short term. PMID:25769506

Cue competition effects in human causal learning.

PubMed

Vogel, Edgar H; Glynn, Jacqueline Y; Wagner, Allan R

2015-01-01

Five experiments involving human causal learning were conducted to compare the cue competition effects known as blocking and unovershadowing, in proactive and retroactive instantiations. Experiment 1 demonstrated reliable proactive blocking and unovershadowing but only retroactive unovershadowing. Experiment 2 replicated the same pattern and showed that the retroactive unovershadowing that was observed was interfered with by a secondary memory task that had no demonstrable effect on either proactive unovershadowing or blocking. Experiments 3a, 3b, and 3c demonstrated that retroactive unovershadowing was accompanied by an inflated memory effect not accompanying proactive unovershadowing. The differential pattern of proactive versus retroactive cue competition effects is discussed in relationship to amenable associative and inferential processing possibilities.

48 CFR 52.216-6 - Price Redetermination-Retroactive.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Price Redetermination....216-6 Price Redetermination—Retroactive. As prescribed in 16.206-4, insert the following clause: Price Redetermination—Retroactive (OCT 1997) (a) General. The unit price and the total price stated in this contract...

75 FR 19878 - Retroactive Stop Loss Special Pay Compensation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... 0790-AI59] Retroactive Stop Loss Special Pay Compensation AGENCY: Office of the Under Secretary of... Stop Loss Special Pay as authorized and appropriated in The Supplemental Appropriations Act, 2009. This... claims to the Secretaries of the Military Departments for Retroactive Stop Loss Special Pay is October 21...

Effects of prestudy and poststudy rest on memory: Support for temporal interference accounts of forgetting.

PubMed

Ecker, Ullrich K H; Tay, Jia-Xin; Brown, Gordon D A

2015-06-01

According to interference-based theories of memory, including temporal-distinctiveness theory, both prestudy and poststudy rest should have beneficial impacts on memory performance. Specifically, higher temporal isolation of a memorandum should reduce proactive and/or retroactive interference, and thus should result in better recall. In the present study, we investigated the effects of prestudy and poststudy rest in a free recall paradigm. Participants studied three lists of words, separated by either a short or a long period of low mental activity (a tone-detection task). Recall targeted the second list; this list was studied in one of four conditions, defined by the fully crossed factors of prestudy and poststudy rest duration. Two experiments revealed a beneficial effect of prestudy rest (and, to a lesser extent, of poststudy rest) on list recall. This result is in line with interference-based theories of memory. By contrast, a beneficial effect of prestudy rest is not predicted by consolidation accounts of memory and forgetting; our results thus require additional assumptions and/or a better specification of the consolidation process and its time course in order to be reconciled with consolidation theory.

An Experimental Analysis of Memory Processing

PubMed Central

Wright, Anthony A

2007-01-01

Rhesus monkeys were trained and tested in visual and auditory list-memory tasks with sequences of four travel pictures or four natural/environmental sounds followed by single test items. Acquisitions of the visual list-memory task are presented. Visual recency (last item) memory diminished with retention delay, and primacy (first item) memory strengthened. Capuchin monkeys, pigeons, and humans showed similar visual-memory changes. Rhesus learned an auditory memory task and showed octave generalization for some lists of notes—tonal, but not atonal, musical passages. In contrast with visual list memory, auditory primacy memory diminished with delay and auditory recency memory strengthened. Manipulations of interitem intervals, list length, and item presentation frequency revealed proactive and retroactive inhibition among items of individual auditory lists. Repeating visual items from prior lists produced interference (on nonmatching tests) revealing how far back memory extended. The possibility of using the interference function to separate familiarity vs. recollective memory processing is discussed. PMID:18047230

Retroactive Effects of Irrelevant Speech on Serial Recall From Short-Term Memory

ERIC Educational Resources Information Center

Norris, Dennis; Baddeley, Alan D.; Page, Michael P. A.

2004-01-01

The authors report 5 serial-recall experiments. In 4 of the 5 experiments, they show that irrelevant sound (IS) has a retroactive effect on material already in memory. In Experiment 1, IS presented during a filled retention interval had a reliable effect on list recall. Four further experiments, 3 of which used retroactive IS, showed that IS…

On the contribution of motor planning to the retroactive cuing benefit in working memory: Evidence by mu and beta oscillatory activity in the EEG.

PubMed

Schneider, Daniel; Barth, Anna; Wascher, Edmund

2017-11-15

Attention can be allocated toward mental representations in working memory also after the initial encoding of information has been completed. It was shown that focusing on only one item within working memory transfers this representation into a protected state, reducing its susceptibility to interference by incoming signals. The present study investigated the nature of this retroactive cue (retro-cue) benefit by means of oscillatory activity in the EEG. In a working memory task with a retro-cue indicating one, two or three memory representations as relevant and a block-wise distractor display presented after the retro-cue, participants had to remember the orientation of a colored bar. On behavioral level, we found that the interfering effect of the distractor display on memory performance could be prevented when a retro-cue reduced the number of attended representations in working memory. However, only the one-item retro-cue led to an overall increase in task performance compared to a condition without a retro-cue. The neural basis of this special representational status was investigated by means of oscillatory parameters in the EEG and a clustering approach on level of the independent components (ICs) in the signal. The retroactive reduction of attended working memory representations was reflected in a suppression of alpha power over right parietal and parieto-occipital sites. In addition, we found that an IC cluster representing oscillatory activity in the mu/beta range (10-12 Hz and 20-24 Hz) with a source in sensorimotor cortex revealed a power suppression already prior to the memory probe following the one-item retro-cue. This suggests that the retro-cue benefit results in large parts from the possibility to focus attention on one particular item in working memory and initiate motor planning processes already ahead of the probe stimulus indicating the respective response. Copyright © 2017 Elsevier Inc. All rights reserved.

The effect of word length in short-term memory: Is rehearsal necessary?

PubMed

Campoy, Guillermo

2008-05-01

Three experiments investigated the effect of word length on a serial recognition task when rehearsal was prevented by a high presentation rate with no delay between study and test lists. Results showed that lists of short four-phoneme words were better recognized than lists of long six-phoneme words. Moreover, this effect was equivalent to that observed in conditions in which there was a delay between lists, thereby making rehearsal possible in the interval. These findings imply that rehearsal does not play a central role in the origin of the word length effect. An alternative explanation based on differences in the degree of retroactive interference generated by long and short words is proposed.

Memory Operations That Support Language Comprehension: Evidence From Verb-Phrase Ellipsis

PubMed Central

Martin, Andrea E.; McElree, Brian

2010-01-01

Comprehension of verb-phrase ellipsis (VPE) requires reevaluation of recently processed constituents, which often necessitates retrieval of information about the elided constituent from memory. A. E. Martin and B. McElree (2008) argued that representations formed during comprehension are content addressable and that VPE antecedents are retrieved from memory via a cue-dependent direct-access pointer rather than via a search process. This hypothesis was further tested by manipulating the location of interfering material—either before the onset of the antecedent (proactive interference; PI) or intervening between antecedent and ellipsis site (retroactive interference; RI). The speed–accuracy tradeoff procedure was used to measure the time course of VPE processing. The location of the interfering material affected VPE comprehension accuracy: RI conditions engendered lower accuracy than PI conditions. Crucially, location did not affect the speed of processing VPE, which is inconsistent with both forward and backward search mechanisms. The observed time-course profiles are consistent with the hypothesis that VPE antecedents are retrieved via a cue-dependent direct-access operation. PMID:19686017

24 CFR 888.405 - Amount of the retroactive Housing Assistance Payments.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE... retroactive payment, a project owner must, if the information is available, submit documentation of occupancy...

24 CFR 888.405 - Amount of the retroactive Housing Assistance Payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE... retroactive payment, a project owner must, if the information is available, submit documentation of occupancy...

14 CFR 253.9 - Retroactive changes to contracts of carriage

Code of Federal Regulations, 2010 CFR

2010-01-01

... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

14 CFR 253.9 - Retroactive changes to contracts of carriage.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

14 CFR 253.9 - Retroactive changes to contracts of carriage.

Code of Federal Regulations, 2012 CFR

2012-01-01

... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

14 CFR 253.9 - Retroactive changes to contracts of carriage.

Code of Federal Regulations, 2014 CFR

2014-01-01

... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

14 CFR 253.9 - Retroactive changes to contracts of carriage.

Code of Federal Regulations, 2013 CFR

2013-01-01

... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

29 CFR 4281.42 - Retroactive payments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Retroactive payments. 4281.42 Section 4281.42 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY, REORGANIZATION, TERMINATION, AND OTHER RULES APPLICABLE TO MULTIEMPLOYER PLANS DUTIES OF PLAN SPONSOR FOLLOWING MASS...

The infantile psychic trauma from us to Freud: pure trauma, retroactivity and reconstruction.

PubMed

Baranger, M; Baranger, W; Mom, J M

1988-01-01

In the works of Freud, the concept of childhood psychic trauma evolves in the direction of increasing complexity. The authors maintain that this expansion corresponds to a new conception of retroactive temporality (Nachträglich), which is precisely the one we use in the analytic process of reconstruction and historicization from the present toward the past. We are thus led to differentiate the extreme form of the unassimilable 'pure' Trauma, nearly pure death drive, from the retroactively historicized forms which are reintegrated into the continuity of a vital flow of time that we 'invent' in analytic work.

24 CFR 888.315 - Restrictions on retroactive payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM-FAIR MARKET RENTS AND... Elderly or Handicapped, and Special Allocations Projects § 888.315 Restrictions on retroactive payments...

In search of consolidation of short-term memory in nonhuman animals.

PubMed

Calder, Amanda; White, K Geoffrey

2014-03-01

Wixted (Annual Review of Psychology, 55, 235 – 269, 2004) has argued that forgetting is due to consolidation failure. Previous research with humans and nonhuman animals has reported evidence for consolidation in intermediate or long-term memory (LTM). The present study examines whether consolidation occurs in short-term memory in pigeons. Delayed matching-to-sample accuracy was reduced when retroactive interference (an extraneous task in Experiment 1 or houselight illumination in Experiment 2) was interpolated in the retention interval. Accuracy was not greater, however, when interference occurred at the end of the retention interval, as compared with when it occurred at the beginning. That is, there was no evidence for consolidation in short-term memory for pigeons. We did find, however, the beginning–end effect originally reported by Roberts and Grant (Journal of Experimental Psychology: Animal Behavior Processes, 4, 219–236, 1978) and the recovery from forgetting reported by White and Brown (Journal of the Experimental Analysis of Behavior, 96, 177–189, 2011). The results are discussed in relation to temporal distinctiveness theory as an alternative to consolidation.

The effect of spatio-temporal distance between visual stimuli on information processing in children with Specific Language Impairment.

PubMed

Dispaldro, Marco; Corradi, Nicola

2015-01-01

The purpose of this study is to evaluate whether children with Specific Language Impairment (SLI) have a deficit in processing a sequence of two visual stimuli (S1 and S2) presented at different inter-stimulus intervals and in different spatial locations. In particular, the core of this study is to investigate whether S1 identification is disrupted due to a retroactive interference of S2. To this aim, two experiments were planned in which children with SLI and children with typical development (TD), matched by age and non-verbal IQ, were compared (Experiment 1: SLI n=19; TD n=19; Experiment 2: SLI n=16; TD n=16). Results show group differences in the ability to identify a single stimulus surrounded by flankers (Baseline level). Moreover, children with SLI show a stronger negative interference of S2, both for temporal and spatial modulation. These results are discussed in the light of an attentional processing limitation in children with SLI. Copyright © 2015 Elsevier Ltd. All rights reserved.

5 CFR 511.703 - Retroactive effective date.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CLASSIFICATION UNDER THE GENERAL SCHEDULE Effective Dates of Position Classification Actions or Decisions § 511... if the employee is wrongfully demoted. (b) Downgrading. (1) The effective date of a classification appellate certificate or agency appellate decision can be retroactive only if it corrects a classification...

Modular cell biology: retroactivity and insulation

PubMed Central

Del Vecchio, Domitilla; Ninfa, Alexander J; Sontag, Eduardo D

2008-01-01

Modularity plays a fundamental role in the prediction of the behavior of a system from the behavior of its components, guaranteeing that the properties of individual components do not change upon interconnection. Just as electrical, hydraulic, and other physical systems often do not display modularity, nor do many biochemical systems, and specifically, genetic networks. Here, we study the effect of interconnections on the input–output dynamic characteristics of transcriptional components, focusing on a property, which we call ‘retroactivity', that plays a role analogous to non-zero output impedance in electrical systems. In transcriptional networks, retroactivity is large when the amount of transcription factor is comparable to, or smaller than, the amount of promoter-binding sites, or when the affinity of such binding sites is high. To attenuate the effect of retroactivity, we propose a feedback mechanism inspired by the design of amplifiers in electronics. We introduce, in particular, a mechanism based on a phosphorylation–dephosphorylation cycle. This mechanism enjoys a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation reactions. PMID:18277378

5 CFR 1605.13 - Back pay awards and other retroactive pay adjustments.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) The employing agency must give the participant the following options for electing makeup contributions... makeup contributions; or (ii) Instead of making contributions for the period of separation in accordance... deducted before payment or other retroactive pay adjustment. Employee makeup contributions required under...

26 CFR 301.9100-15T - Election to use retroactive effective date.

Code of Federal Regulations, 2010 CFR

2010-04-01

... election—(1) In general. An election under this section changes the effective date of certain amendments to... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Election to use retroactive effective date. 301... (CONTINUED) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION General Rules Application of Internal...

24 CFR 888.305 - Amount of the retroactive Housing Assistance Payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE..., Section 202 Elderly or Handicapped, and Special Allocations Projects § 888.305 Amount of the retroactive... available, submit documentation of occupancy rates, on either an annual or monthly basis, for the same time...

24 CFR 888.305 - Amount of the retroactive Housing Assistance Payments.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE..., Section 202 Elderly or Handicapped, and Special Allocations Projects § 888.305 Amount of the retroactive... available, submit documentation of occupancy rates, on either an annual or monthly basis, for the same time...

5 CFR 894.505 - Are retroactive premiums paid with pre-tax dollars (premium conversion)?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Are retroactive premiums paid with pre-tax dollars (premium conversion)? 894.505 Section 894.505 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE...

5 CFR 894.505 - Are retroactive premiums paid with pre-tax dollars (premium conversion)?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Are retroactive premiums paid with pre-tax dollars (premium conversion)? 894.505 Section 894.505 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE...

20 CFR 416.1202 - Deeming of resources.

Code of Federal Regulations, 2010 CFR

2010-04-01

... unspent portion of any retroactive payment of family separation allowance an ineligible parent (or... retroactive payment of family separation allowance an ineligible spouse received from one of the uniformed... her ineligible parent who is living in the same household with him or her (as described in § 416.1851...

24 CFR 888.410 - Notice of eligibility requirements for retroactive payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., SECTION 202 DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811... establishment of the amount of the retroactive payment, as described in § 888.401 (a) and (b), and documentation... owner who is unable to certify must present documentation of an agreement between the current and former...

24 CFR 888.410 - Notice of eligibility requirements for retroactive payments.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., SECTION 202 DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811... establishment of the amount of the retroactive payment, as described in § 888.401 (a) and (b), and documentation... owner who is unable to certify must present documentation of an agreement between the current and former...

20 CFR 10.903 - Is the death gratuity payment applicable retroactively?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Is the death gratuity payment applicable...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.903 Is the death gratuity payment applicable retroactively? An employee's death qualifies for the death gratuity if the employee died on or after October 7, 2001, and...

26 CFR 54.4975-11 - “ESOP” requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., 1977. (4) Retroactive amendment. A plan meets the requirements of this section as of the date that it is designated as an ESOP if it is amended retroactively to meet, and in fact does meet, such... such date may remain integrated. However, such plans must not be amended to increase the integration...

26 CFR 54.4975-11 - “ESOP” requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., 1977. (4) Retroactive amendment. A plan meets the requirements of this section as of the date that it is designated as an ESOP if it is amended retroactively to meet, and in fact does meet, such... such date may remain integrated. However, such plans must not be amended to increase the integration...

26 CFR 54.4975-11 - “ESOP” requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., 1977. (4) Retroactive amendment. A plan meets the requirements of this section as of the date that it is designated as an ESOP if it is amended retroactively to meet, and in fact does meet, such... such date may remain integrated. However, such plans must not be amended to increase the integration...

26 CFR 54.4975-11 - “ESOP” requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., 1977. (4) Retroactive amendment. A plan meets the requirements of this section as of the date that it is designated as an ESOP if it is amended retroactively to meet, and in fact does meet, such... such date may remain integrated. However, such plans must not be amended to increase the integration...

42 CFR 412.130 - Retroactive adjustments for incorrectly excluded hospitals and units.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Payments to Hospitals Under the Prospective Payment Systems § 412.130 Retroactive adjustments for... hospital that was excluded from the prospective payment systems specified in § 412.1(a)(1) or paid under...

Response Requirement and Nature of Interpolated Stories in Retroactive Inhibition in Prose.

ERIC Educational Resources Information Center

Van Mondfrans, Adrian P.; And Others

Retroactive inhibition, a loss of memory due to learning other materials between recall and exposure to the original materials, was investigated in relation to prose. Two variables were manipulated in the study: similarity of interpolated stories (dissimilar or similar), and the response requirements (completion-recall or multiple-choice). The 190…

78 FR 17996 - MCM Rail Services LLC-Petition for Retroactive Exemption-In Sparrows Point, Md.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-25

... LLC--Petition for Retroactive Exemption--In Sparrows Point, Md. AGENCY: Surface Transportation Board... of rail line in Sparrows Point, Md. (the Line). DATES: MCM's supplemental information is due by April... Railroad, and currently named the Baltimore Industrial Railway, is located at 1430 Sparrows Point Boulevard...

20 CFR 10.903 - Is the death gratuity payment applicable retroactively?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Is the death gratuity payment applicable...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.903 Is the death gratuity payment applicable retroactively? An employee's death qualifies for the death gratuity if the employee died on or after October 7, 2001, and...

20 CFR 10.903 - Is the death gratuity payment applicable retroactively?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Is the death gratuity payment applicable...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.903 Is the death gratuity payment applicable retroactively? An employee's death qualifies for the death gratuity if the employee died on or after October 7, 2001, and...

20 CFR 10.903 - Is the death gratuity payment applicable retroactively?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Is the death gratuity payment applicable...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.903 Is the death gratuity payment applicable retroactively? An employee's death qualifies for the death gratuity if the employee died on or after October 7, 2001, and...

20 CFR 10.903 - Is the death gratuity payment applicable retroactively?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Is the death gratuity payment applicable...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.903 Is the death gratuity payment applicable retroactively? An employee's death qualifies for the death gratuity if the employee died on or after October 7, 2001, and...

Retroactivity in the Context of Modularly Structured Biomolecular Systems

PubMed Central

Pantoja-Hernández, Libertad; Martínez-García, Juan Carlos

2015-01-01

Synthetic biology has intensively promoted the technical implementation of modular strategies in the fabrication of biological devices. Modules are considered as networks of reactions. The behavior displayed by biomolecular systems results from the information processes carried out by the interconnection of the involved modules. However, in natural systems, module wiring is not a free-of-charge process; as a consequence of interconnection, a reactive phenomenon called retroactivity emerges. This phenomenon is characterized by signals that propagate from downstream modules (the modules that receive the incoming signals upon interconnection) to upstream ones (the modules that send the signals upon interconnection). Such retroactivity signals, depending of their strength, may change and sometimes even disrupt the behavior of modular biomolecular systems. Thus, analysis of retroactivity effects in natural biological and biosynthetic systems is crucial to achieve a deeper understanding of how this interconnection between functionally characterized modules takes place and how it impacts the overall behavior of the involved cell. By discussing the modules interconnection in natural and synthetic biomolecular systems, we propose that such systems should be considered as quasi-modular. PMID:26137457

Measuring Investment in Learning: Can Electrocardiogram Provide an Indication of Cognitive Effort During Learning?

PubMed

Patterson, Jae T; Hart, Amanda; Hansen, Steve; Carter, Michael J; Ditor, David

2016-04-01

Heart rate variability (i.e., low frequency:high frequency ratio) was measured to differentiate invested cognitive effort during the acquisition and retention of a novel task. Participants (12 male, M = 25.1 year, SD = 3.6; 12 female, M = 22.8 year, SD = 1.1) were required to produce Braille equivalents of English letter primes on a standardized keyboard in proactive or retroactive conditions (groups, each n = 12). The correct Braille response was either provided before (i.e., proactively) or after (i.e., retroactively) the participant's response. During acquisition, participants in the proactive group demonstrated shorter study time, greater recall success, and reported lower cognitive investment. Participants in the proactive and retroactive groups did not statistically differ in heart rate variability. For retention, the retroactive group showed greater recall success, lower perceived cognitive effort investment, and lower heart rate variability. The results highlight the usefulness of heart rate variability in discriminating the cognitive effort invested for a recently acquired skill. © The Author(s) 2016.

The protective effects of acute cardiovascular exercise on the interference of procedural memory.

PubMed

Jo, J S; Chen, J; Riechman, S; Roig, M; Wright, D L

2018-04-10

Numerous studies have reported a positive impact of acute exercise for procedural skill memory. Previous work has revealed this effect, but these findings are confounded by a potential contribution of a night of sleep to the reported exercise-mediated reduction in interference. Thus, it remains unclear if exposure to a brief bout of exercise can provide protection to a newly acquired motor memory. The primary objective of the present study was to examine if a single bout of moderate-intensity cardiovascular exercise after practice of a novel motor sequence reduces the susceptibility to retroactive interference. To address this shortcoming, 17 individuals in a control condition practiced a novel motor sequence that was followed by test after a 6-h wake-filled interval. A separate group of 17 individuals experienced practice with an interfering motor sequence 45 min after practice with the original sequence and were then administered test trials 6 h later. One additional group of 12 participants was exposed to an acute bout of exercise immediately after practice with the original motor sequence but prior to practice with the interfering motor sequence and the subsequent test. In comparison with the control condition, increased response times were revealed during the 6-h test for the individuals that were exposed to interference. The introduction of an acute bout of exercise between the practice of the two motor sequences produced a reduction in interference from practice with the second task at the time of test, however, this effect was not statistically significant. These data reinforce the hypothesis that while there may be a contribution from exercise to post-practice consolidation of procedural skills which is independent of sleep, sleep may interact with exercise to strengthen the effects of the latter on procedural memory.

26 CFR 31.3121(k)-2 - Waivers of exemption; original effective date changed retroactively.

Code of Federal Regulations, 2011 CFR

2011-04-01

... changed retroactively. 31.3121(k)-2 Section 31.3121(k)-2 Internal Revenue INTERNAL REVENUE SERVICE... Revenue Code of 1954) General Provisions § 31.3121(k)-2 Waivers of exemption; original effective date... which filed a certificate under section 3121(k) after 1955 and before August 29, 1958, may file a...

26 CFR 31.3121(k)-2 - Waivers of exemption; original effective date changed retroactively.

Code of Federal Regulations, 2012 CFR

2012-04-01

... changed retroactively. 31.3121(k)-2 Section 31.3121(k)-2 Internal Revenue INTERNAL REVENUE SERVICE... Revenue Code of 1954) General Provisions § 31.3121(k)-2 Waivers of exemption; original effective date... which filed a certificate under section 3121(k) after 1955 and before August 29, 1958, may file a...

26 CFR 31.3121(k)-2 - Waivers of exemption; original effective date changed retroactively.

Code of Federal Regulations, 2014 CFR

2014-04-01

... changed retroactively. 31.3121(k)-2 Section 31.3121(k)-2 Internal Revenue INTERNAL REVENUE SERVICE... Revenue Code of 1954) General Provisions § 31.3121(k)-2 Waivers of exemption; original effective date... which filed a certificate under section 3121(k) after 1955 and before August 29, 1958, may file a...

26 CFR 31.3121(k)-2 - Waivers of exemption; original effective date changed retroactively.

Code of Federal Regulations, 2013 CFR

2013-04-01

... changed retroactively. 31.3121(k)-2 Section 31.3121(k)-2 Internal Revenue INTERNAL REVENUE SERVICE... Revenue Code of 1954) General Provisions § 31.3121(k)-2 Waivers of exemption; original effective date... which filed a certificate under section 3121(k) after 1955 and before August 29, 1958, may file a...

26 CFR 31.3121(k)-2 - Waivers of exemption; original effective date changed retroactively.

Code of Federal Regulations, 2010 CFR

2010-04-01

... changed retroactively. 31.3121(k)-2 Section 31.3121(k)-2 Internal Revenue INTERNAL REVENUE SERVICE... Revenue Code of 1954) General Provisions § 31.3121(k)-2 Waivers of exemption; original effective date... which filed a certificate under section 3121(k) after 1955 and before August 29, 1958, may file a...

20 CFR 404.408b - Reduction of retroactive monthly social security benefits where supplemental security income (SSI...

Code of Federal Regulations, 2011 CFR

2011-04-01

... required where there is a change in your month of entitlement or the amount of your social security... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Reduction of retroactive monthly social....408b Section 404.408b Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND...

20 CFR 404.408b - Reduction of retroactive monthly social security benefits where supplemental security income (SSI...

Code of Federal Regulations, 2010 CFR

2010-04-01

... required where there is a change in your month of entitlement or the amount of your social security... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Reduction of retroactive monthly social....408b Section 404.408b Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND...

Cognitive Retroactive Transfer (CRT) of Language Skills among Bilingual Arabic-English Readers

ERIC Educational Resources Information Center

Abu-Rabia, Salim; Shakkour, Wael; Siegel, Linda

2013-01-01

This study examined the effects of an intervention helping struggling readers improve their reading and writing skills in English as a foreign language (L2), and those same skills in Arabic, which was their first language (L1). Transferring linguistic skills from L2 to L1 is termed "cognitive retroactive transfer". Tests were…

Synaptic consolidation as a temporally variable process: Uncovering the parameters modulating its time-course.

PubMed

Casagrande, Mirelle A; Haubrich, Josué; Pedraza, Lizeth K; Popik, Bruno; Quillfeldt, Jorge A; de Oliveira Alvares, Lucas

2018-04-01

Memories are not instantly created in the brain, requiring a gradual stabilization process called consolidation to be stored and persist in a long-lasting manner. However, little is known whether this time-dependent process is dynamic or static, and the factors that might modulate it. Here, we hypothesized that the time-course of consolidation could be affected by specific learning parameters, changing the time window where memory is susceptible to retroactive interference. In the rodent contextual fear conditioning paradigm, we compared weak and strong training protocols and found that in the latter memory is susceptible to post-training hippocampal inactivation for a shorter period of time. The accelerated consolidation process triggered by the strong training was mediated by glucocorticoids, since this effect was blocked by pre-training administration of metyrapone. In addition, we found that pre-exposure to the training context also accelerates fear memory consolidation. Hence, our results demonstrate that the time window in which memory is susceptible to post-training interferences varies depending on fear conditioning intensity and contextual familiarity. We propose that the time-course of memory consolidation is dynamic, being directly affected by attributes of the learning experiences. Copyright © 2018 Elsevier Inc. All rights reserved.

Reaching back: the relative strength of the retroactive emotional attentional blink

PubMed Central

Ní Choisdealbha, Áine; Piech, Richard M.; Fuller, John K.; Zald, David H.

2017-01-01

Visual stimuli with emotional content appearing in close temporal proximity either before or after a target stimulus can hinder conscious perceptual processing of the target via an emotional attentional blink (EAB). This occurs for targets that appear after the emotional stimulus (forward EAB) and for those appearing before the emotional stimulus (retroactive EAB). Additionally, the traditional attentional blink (AB) occurs because detection of any target hinders detection of a subsequent target. The present study investigated the relations between these different attentional processes. Rapid sequences of landscape images were presented to thirty-one male participants with occasional landscape targets (rotated images). For the forward EAB, emotional or neutral distractor images of people were presented before the target; for the retroactive EAB, such images were also targets and presented after the landscape target. In the latter case, this design allowed investigation of the AB as well. Erotic and gory images caused more EABs than neutral images, but there were no differential effects on the AB. This pattern is striking because while using different target categories (rotated landscapes, people) appears to have eliminated the AB, the retroactive EAB still occurred, offering additional evidence for the power of emotional stimuli over conscious attention. PMID:28255172

F-16 Instructional Sequencing Plan Report.

DTIC Science & Technology

1981-03-01

information). 2. Interference (learning of some tasks interferes with the learning of other tasks when they possess similar but confusing differences ...profound effect on the total training expense. This increases the desirability of systematic, precise methods of syllabus generation. Inherent in a given...the expensive to acquire. resource. Least cost The syllabus must Select sequences which provide a least total make maximum use of cost method of

20 CFR 1002.138 - If the employee receives a retroactive upgrade in the characterization of service, will that...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false If the employee receives a retroactive upgrade in the characterization of service, will that entitle him or her to claim back wages and benefits... service, will that entitle him or her to claim back wages and benefits lost as of the date of separation...

Retroactive Seniority as a Remedy for Title VII Violations: Relief to Newly Hired and Incumbent Employees in Light of Franks v. Bowman

ERIC Educational Resources Information Center

Stern, Lynne Rothschild

1976-01-01

Franks v. Bowman Transportation Co. set forth the principles for determining whether a seniority system violates Title VII and awarded retroactive seniority to a limited group of employees previously denied employment due to their minority status. This ruling is examined in terms of the rights of non-minority employees. Available from: Loyola…

Signaling Architectures that Transmit Unidirectional Information Despite Retroactivity.

PubMed

Shah, Rushina; Del Vecchio, Domitilla

2017-08-08

A signaling pathway transmits information from an upstream system to downstream systems, ideally in a unidirectional fashion. A key obstacle to unidirectional transmission is retroactivity, the additional reaction flux that affects a system once its species interact with those of downstream systems. This raises the fundamental question of whether signaling pathways have developed specialized architectures that overcome retroactivity and transmit unidirectional signals. Here, we propose a general procedure based on mathematical analysis that provides an answer to this question. Using this procedure, we analyze the ability of a variety of signaling architectures to transmit one-way (from upstream to downstream) signals, as key biological parameters are tuned. We find that single stage phosphorylation and phosphotransfer systems that transmit signals from a kinase show a stringent design tradeoff that hampers their ability to overcome retroactivity. Interestingly, cascades of these architectures, which are highly represented in nature, can overcome this tradeoff and thus enable unidirectional transmission. By contrast, phosphotransfer systems, and single and double phosphorylation cycles that transmit signals from a substrate, are unable to mitigate retroactivity effects, even when cascaded, and hence are not well suited for unidirectional information transmission. These results are largely independent of the specific reaction-rate constant values, and depend on the topology of the architectures. Our results therefore identify signaling architectures that, allowing unidirectional transmission of signals, embody modular processes that conserve their input/output behavior across multiple contexts. These findings can be used to decompose natural signal transduction networks into modules, and at the same time, they establish a library of devices that can be used in synthetic biology to facilitate modular circuit design. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Inconsistent-handed advantage in episodic memory extends to paragraph-level materials.

PubMed

Prichard, Eric C; Christman, Stephen D

2017-09-01

Past research using handedness as a proxy for functional access to the right hemisphere demonstrates that individuals who are mixed/inconsistently handed outperform strong/consistently handed individuals when performing episodic recall tasks. However, research has generally been restricted to stimuli presented in a list format. In the present paper, we present two studies in which participants were presented with paragraph-level material and then asked to recall material from the passages. The first study was based on a classic study looking at retroactive interference with prose materials. The second was modelled on a classic experiment looking at perspective taking and the content of memory. In both studies, the classic effects were replicated and the general finding that mixed/inconsistent-handers outperform strong/consistent-handers was replicated. This suggests that considering degree of handedness may be an empirically useful means of reducing error variance in paradigms looking at memory for prose level material.

Design of agricultural product quality safety retrospective supervision system of Jiangsu province

NASA Astrophysics Data System (ADS)

Wang, Kun

2017-08-01

In store and supermarkets to consumers can trace back agricultural products through the electronic province card to query their origin, planting, processing, packaging, testing and other important information and found that the problems. Quality and safety issues can identify the responsibility of the problem. This paper designs a retroactive supervision system for the quality and safety of agricultural products in Jiangsu Province. Based on the analysis of agricultural production and business process, the goal of Jiangsu agricultural product quality safety traceability system construction is established, and the specific functional requirements and non-functioning requirements of the retroactive system are analyzed, and the target is specified for the specific construction of the retroactive system. The design of the quality and safety traceability system in Jiangsu province contains the design of the overall design, the trace code design and the system function module.

26 CFR 11.412(c)-7 - Election to treat certain retroactive plan amendments as made on the first day of the plan year.

Code of Federal Regulations, 2012 CFR

2012-04-01

... amendments as made on the first day of the plan year. 11.412(c)-7 Section 11.412(c)-7 Internal Revenue... treat certain retroactive plan amendments as made on the first day of the plan year. (a) General rule... the date of the close of the first plan year to which the amendment applies and the date on which the...

26 CFR 11.412(c)-7 - Election to treat certain retroactive plan amendments as made on the first day of the plan year.

Code of Federal Regulations, 2010 CFR

2010-04-01

... amendments as made on the first day of the plan year. 11.412(c)-7 Section 11.412(c)-7 Internal Revenue... treat certain retroactive plan amendments as made on the first day of the plan year. (a) General rule... the date of the close of the first plan year to which the amendment applies and the date on which the...

26 CFR 11.412(c)-7 - Election to treat certain retroactive plan amendments as made on the first day of the plan year.

Code of Federal Regulations, 2014 CFR

2014-04-01

... amendments as made on the first day of the plan year. 11.412(c)-7 Section 11.412(c)-7 Internal Revenue... treat certain retroactive plan amendments as made on the first day of the plan year. (a) General rule... the date of the close of the first plan year to which the amendment applies and the date on which the...

26 CFR 11.412(c)-7 - Election to treat certain retroactive plan amendments as made on the first day of the plan year.

Code of Federal Regulations, 2013 CFR

2013-04-01

... amendments as made on the first day of the plan year. 11.412(c)-7 Section 11.412(c)-7 Internal Revenue... treat certain retroactive plan amendments as made on the first day of the plan year. (a) General rule... the date of the close of the first plan year to which the amendment applies and the date on which the...

26 CFR 11.412(c)-7 - Election to treat certain retroactive plan amendments as made on the first day of the plan year.

Code of Federal Regulations, 2011 CFR

2011-04-01

... amendments as made on the first day of the plan year. 11.412(c)-7 Section 11.412(c)-7 Internal Revenue... treat certain retroactive plan amendments as made on the first day of the plan year. (a) General rule... the date of the close of the first plan year to which the amendment applies and the date on which the...

Failing the Future: Three Unsuccessful Attempts to Replicate Bem's ‘Retroactive Facilitation of Recall’ Effect

PubMed Central

Ritchie, Stuart J.; Wiseman, Richard; French, Christopher C.

2012-01-01

Nine recently reported parapsychological experiments appear to support the existence of precognition. We describe three pre-registered independent attempts to exactly replicate one of these experiments, ‘retroactive facilitation of recall’, which examines whether performance on a memory test can be influenced by a post-test exercise. All three replication attempts failed to produce significant effects (combined n = 150; combined p = .83, one-tailed) and thus do not support the existence of psychic ability. PMID:22432019

Dual-task interference in visual working memory: A limitation in storage capacity but not in encoding or retrieval

PubMed Central

Fougnie, Daryl; Marois, René

2009-01-01

The concurrent maintenance of two visual working memory (VWM) arrays can lead to profound interference. It is unclear, however, whether these costs arise from limitations in VWM storage capacity (Fougnie & Marois, 2006), or from interference between the storage of one visual array and encoding or retrieval of another visual array (Cowan & Morey, 2007). Here, we show that encoding a VWM array does not interfere with maintenance of another VWM array unless the two displays exceed maintenance capacity (Experiments 1 and 2). Moreover, manipulating the extent to which encoding and maintenance can interfere with one another had no discernable effect on dual-task performance (Experiment 2). Finally, maintenance of a VWM array was not affected by retrieval of information from another VWM array (Experiment 3). Taken together, these findings demonstrate that dual-task interference between two concurrent VWM tasks is due to a capacity-limited store that is independent from encoding and retrieval processes. PMID:19933566

Efficacy of Occupational Therapy Using Ayres Sensory Integration®: A Systematic Review.

PubMed

Schaaf, Roseann C; Dumont, Rachel L; Arbesman, Marian; May-Benson, Teresa A

This systematic review addresses the question "What is the efficacy of occupational therapy using Ayres Sensory Integration ® (ASI) to support functioning and participation as defined by the International Classification of Functioning, Disability and Health for persons with challenges in processing and integrating sensory information that interfere with everyday life participation?" Three randomized controlled trials, 1 retroactive analysis, and 1 single-subject ABA design published from 2007 to 2015, all of which happened to study children with autism, met inclusion criteria. The evidence is strong that ASI intervention demonstrates positive outcomes for improving individually generated goals of functioning and participation as measured by Goal Attainment Scaling for children with autism. Moderate evidence supported improvements in impairment-level outcomes of improvement in autistic behaviors and skills-based outcomes of reduction in caregiver assistance with self-care activities. Child outcomes in play, sensory-motor, and language skills and reduced caregiver assistance with social skills had emerging but insufficient evidence. Copyright © 2018 by the American Occupational Therapy Association, Inc.

A model of human motor sequence learning explains facilitation and interference effects based on spike-timing dependent plasticity.

PubMed

Wang, Quan; Rothkopf, Constantin A; Triesch, Jochen

2017-08-01

The ability to learn sequential behaviors is a fundamental property of our brains. Yet a long stream of studies including recent experiments investigating motor sequence learning in adult human subjects have produced a number of puzzling and seemingly contradictory results. In particular, when subjects have to learn multiple action sequences, learning is sometimes impaired by proactive and retroactive interference effects. In other situations, however, learning is accelerated as reflected in facilitation and transfer effects. At present it is unclear what the underlying neural mechanism are that give rise to these diverse findings. Here we show that a recently developed recurrent neural network model readily reproduces this diverse set of findings. The self-organizing recurrent neural network (SORN) model is a network of recurrently connected threshold units that combines a simplified form of spike-timing dependent plasticity (STDP) with homeostatic plasticity mechanisms ensuring network stability, namely intrinsic plasticity (IP) and synaptic normalization (SN). When trained on sequence learning tasks modeled after recent experiments we find that it reproduces the full range of interference, facilitation, and transfer effects. We show how these effects are rooted in the network's changing internal representation of the different sequences across learning and how they depend on an interaction of training schedule and task similarity. Furthermore, since learning in the model is based on fundamental neuronal plasticity mechanisms, the model reveals how these plasticity mechanisms are ultimately responsible for the network's sequence learning abilities. In particular, we find that all three plasticity mechanisms are essential for the network to learn effective internal models of the different training sequences. This ability to form effective internal models is also the basis for the observed interference and facilitation effects. This suggests that STDP, IP, and SN may be the driving forces behind our ability to learn complex action sequences.

A Novel Cognitive Stress Test for the Detection of Preclinical Alzheimer Disease: Discriminative Properties and Relation to Amyloid Load.

PubMed

Loewenstein, David A; Curiel, Rosie E; Greig, Maria T; Bauer, Russell M; Rosado, Marian; Bowers, Dawn; Wicklund, Meredith; Crocco, Elizabeth; Pontecorvo, Michael; Joshi, Abhinay D; Rodriguez, Rosemarie; Barker, Warren W; Hidalgo, Jacqueline; Duara, Ranjan

2016-10-01

To examine the utility of a novel "cognitive stress test" to detect subtle cognitive impairments and amyloid load within the brains of neuropsychologically normal community-dwelling elders. Participants diagnosed as cognitively normal (CN), subjective memory impairment (SMI), mild cognitive impairment (MCI), and preclinical mild cognitive impairment (PreMCI) were administered the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), a sensitive test of proactive semantic interference (PSI), retroactive semantic interference, and, uniquely, the ability to recover from the effects of PSI. Ninety-three subjects (31 men and 62 women) were recruited from three academic institutions in a research consortium. A subset of these individuals underwent 18F florbetapir positron emission tomography scanning. Relative percentages of impairment for each diagnostic group on the LASSI-L were calculated by χ(2) and Fisher's exact tests. Spearman's rho was used to examine associations between amyloid load and different cognitive measures. LASSI-L deficits were identified among 89% of those with MCI, 47% with PreMCI, 33% with SMI, and 13% classified as CN. CN subjects had no difficulties with recovery from PSI, whereas SMI, preMCI, and MCI participants evidenced deficits in recovery from PSI effects. Among a subgroup of participants with normal scores on traditional neuropsychological tests, the strong associations were between the failure to recover from the effects of PSI and amyloid load in the brain. Failure to recover or compensate for the effects of PSI on the LASSI-L distinguishes the LASSI-L from other widely used neuropsychological tests and appears to be sensitive to subtle cognitive impairments and increasing amyloid load. Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Playing the computer game Tetris prior to viewing traumatic film material and subsequent intrusive memories: Examining proactive interference.

PubMed

James, Ella L; Lau-Zhu, Alex; Tickle, Hannah; Horsch, Antje; Holmes, Emily A

2016-12-01

Visuospatial working memory (WM) tasks performed concurrently or after an experimental trauma (traumatic film viewing) have been shown to reduce subsequent intrusive memories (concurrent or retroactive interference, respectively). This effect is thought to arise because, during the time window of memory consolidation, the film memory is labile and vulnerable to interference by the WM task. However, it is not known whether tasks before an experimental trauma (i.e. proactive interference) would also be effective. Therefore, we tested if a visuospatial WM task given before a traumatic film reduced intrusions. Findings are relevant to the development of preventative strategies to reduce intrusive memories of trauma for groups who are routinely exposed to trauma (e.g. emergency services personnel) and for whom tasks prior to trauma exposure might be beneficial. Participants were randomly assigned to 1 of 2 conditions. In the Tetris condition (n = 28), participants engaged in the computer game for 11 min immediately before viewing a 12-min traumatic film, whereas those in the Control condition (n = 28) had no task during this period. Intrusive memory frequency was assessed using an intrusion diary over 1-week and an Intrusion Provocation Task at 1-week follow-up. Recognition memory for the film was also assessed at 1-week. Compared to the Control condition, participants in the Tetris condition did not report statistically significant difference in intrusive memories of the trauma film on either measure. There was also no statistically significant difference in recognition memory scores between conditions. The study used an experimental trauma paradigm and findings may not be generalizable to a clinical population. Compared to control, playing Tetris before viewing a trauma film did not lead to a statistically significant reduction in the frequency of later intrusive memories of the film. It is unlikely that proactive interference, at least with this task, effectively influences intrusive memory development. WM tasks administered during or after trauma stimuli, rather than proactively, may be a better focus for intrusive memory amelioration. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Stochastic modular analysis for gene circuits: interplay among retroactivity, nonlinearity, and stochasticity.

PubMed

Kim, Kyung Hyuk; Sauro, Herbert M

2015-01-01

This chapter introduces a computational analysis method for analyzing gene circuit dynamics in terms of modules while taking into account stochasticity, system nonlinearity, and retroactivity. (1) ANALOG ELECTRICAL CIRCUIT REPRESENTATION FOR GENE CIRCUITS: A connection between two gene circuit components is often mediated by a transcription factor (TF) and the connection signal is described by the TF concentration. The TF is sequestered to its specific binding site (promoter region) and regulates downstream transcription. This sequestration has been known to affect the dynamics of the TF by increasing its response time. The downstream effect-retroactivity-has been shown to be explicitly described in an electrical circuit representation, as an input capacitance increase. We provide a brief review on this topic. (2) MODULAR DESCRIPTION OF NOISE PROPAGATION: Gene circuit signals are noisy due to the random nature of biological reactions. The noisy fluctuations in TF concentrations affect downstream regulation. Thus, noise can propagate throughout the connected system components. This can cause different circuit components to behave in a statistically dependent manner, hampering a modular analysis. Here, we show that the modular analysis is still possible at the linear noise approximation level. (3) NOISE EFFECT ON MODULE INPUT-OUTPUT RESPONSE: We investigate how to deal with a module input-output response and its noise dependency. Noise-induced phenotypes are described as an interplay between system nonlinearity and signal noise. Lastly, we provide the comprehensive approach incorporating the above three analysis methods, which we call "stochastic modular analysis." This method can provide an analysis framework for gene circuit dynamics when the nontrivial effects of retroactivity, stochasticity, and nonlinearity need to be taken into account.

Intrusions in Episodic Memory: Reconsolidation or Interference?

ERIC Educational Resources Information Center

Klingmüller, Angela; Caplan, Jeremy B.; Sommer, Tobias

2017-01-01

It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a…

Single-trial evaluative conditioning can be moderated by instructed forgetting.

PubMed

Gast, Anne; Kattner, Florian

2016-09-01

Evaluative conditioning (EC) is a change in the valence of a conditioned stimulus (CS) due to previous pairing with an affective unconditioned stimulus (US). Several previous studies indicate that EC is related to memory of the CS-US pairs. Previous studies, however, typically cannot distinguish between the influence of CS-US knowledge during measurement and during encoding. In addition, by measuring rather than manipulating memory, they do not test the causal effect of memory on EC. The present study employed a "directed forgetting" procedure to the EC paradigm instructing participants to either forget or remember certain CS-US pairs. We found that EC effects after single learning trials were stronger for to-be-remembered than for to-be-forgotten pairs. Manipulation checks showed that the forgetting manipulation also successfully modulated memory for the target pairs and reduced both retroactive and proactive interference on memory for other pairs. Item-based analyses further demonstrated that the size of EC depended on CS-US memory. The results suggest that EC relies on available memory during measurement of the EC effect.

Explicit instructions and consolidation promote rewiring of automatic behaviors in the human mind.

PubMed

Szegedi-Hallgató, Emese; Janacsek, Karolina; Vékony, Teodóra; Tasi, Lia Andrea; Kerepes, Leila; Hompoth, Emőke Adrienn; Bálint, Anna; Németh, Dezső

2017-06-29

One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our knowledge of sequential/statistical regularities when they change. The dynamics of rewiring was explored from learning to consolidation using a unique experimental design which is suitable to capture the effect of implicit and explicit processing and the proactive and retroactive interference. Our results indicate that humans can rewire their knowledge of such regularities incidentally, and consolidation has a critical role in this process. Moreover, old and new knowledge can coexist, leading to effective adaptivity of the human mind in the changing environment, although the execution of the recently acquired knowledge may be more fluent than the execution of the previously learned one. These findings can contribute to a better understanding of the cognitive processes underlying behavior change, and can provide insights into how we can boost behavior change in various contexts, such as sports, educational settings or psychotherapy.

Maternal obesity in the agouti viable yellow (Avy) mouse produces defective secretory activation that is associated with mammary inflammation and activation of adrenocorticosteroid-dependent gene expression

USDA-ARS?s Scientific Manuscript database

Maternal obesity is known to interfere with normal lactation in women, rodents, and dairy animals. Obesity is also correlated with profound changes in an array of endocrine factors and is causally linked with inflammation and insulin resistance. Recent work suggests that elevated aldosterone actin...

Implementation of Rule 8 of the International Code of Nomenclature of Prokaryotes for the renaming of classes. Request for an Opinion.

PubMed

Oren, Aharon; Parte, Aidan; Garrity, George M

2016-10-01

The new version of Rule 8 of the International Code of Nomenclature of Prokaryotes as approved in Istanbul in 2008 has the clear advantage of establishing a uniform way to name classes of prokaryotes, similar to the way other higher taxa are named. However, retroactive implementation of the modified Rule is problematic as it destabilizes the nomenclature and requires the replacement of a large number of names of classes that have been validly published, which would be in violation of Principle 1 of the Code. Therefore, we call upon the International Committee on Systematics of Prokaryotes and its Judicial Commission to reconsider the retroactivity of Rule 8.

42 CFR 413.9 - Cost related to patient care.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING FACILITIES Introduction and General... after the provider has submitted fiscal and statistical reports. The retroactive adjustment will...

Empirical retrocausality: Testing physics hypotheses with parapsychological experiments

NASA Astrophysics Data System (ADS)

Dobyns, York

2017-05-01

In 2011, Daryl Bem published a report of nine parapsychological experiments showing evidence of retrocausal information transfer. Earlier in 2016, the team of Bem, Tressoldi, Rabeyron, and Duggan published the results of a meta-analysis containing 81 independent replications of the original Bem experiments (total of 90 with the originals).[1] This much larger database continues to show positive results of generally comparable effect size, thus demonstrating that the effects claimed by Bem can be replicated by independent researchers and greatly strengthening the case for empirically observed retrocausation. Earlier (2011) work by this author showed how a modification of one of Bem's original experiments could be used to test the mechanism implicitly proposed by Echeverria, Klinkhammer, and Thorne to explain how retrocausal phenomena can exist without any risk of self-contradictory event sequences (time paradoxes). In light of the new publication and new evidence, the current work generalizes the previous analysis which was restricted to only one of Bem's experimental genres (precognitive approach and avoidance). The current analysis shows how minor modifications can be made in Bem's other experimental genres of retroactive priming, retroactive habituation, and retroactive facilitation of recall to test the EKT anti-paradox mechanism. If the EKT hypothesis is correct, the modified experiments, while continuing to show replicable retrocausal phenomena, will also show a characteristic pattern of distortion in the statistics of the random selections used to drive the experiments.

32 CFR 279.4 - Claims process.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Retroactive Stop Loss Special Pay. This notification should reflect the estimated number of eligible months... from the individual's chain of command. (4) Establish claim and appellate procedures, websites, points...

32 CFR 279.4 - Claims process.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Retroactive Stop Loss Special Pay. This notification should reflect the estimated number of eligible months... from the individual's chain of command. (4) Establish claim and appellate procedures, websites, points...

32 CFR 279.4 - Claims process.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Retroactive Stop Loss Special Pay. This notification should reflect the estimated number of eligible months... from the individual's chain of command. (4) Establish claim and appellate procedures, websites, points...

32 CFR 279.4 - Claims process.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Retroactive Stop Loss Special Pay. This notification should reflect the estimated number of eligible months... from the individual's chain of command. (4) Establish claim and appellate procedures, websites, points...

Electron Localization in Dissociating H 2 + by Retroaction of a Photoelectron onto Its Source

DOE PAGES

Waitz, M.; Asliturk, D.; Wechselberger, N.; ...

2016-01-26

We investigate the dissociation of H 2 + into a proton and a H 0 after single ionization with photons of an energy close to the threshold. We find that the p + and the H 0 do not emerge symmetrically in the case of the H 2 + dissociating along the 1sσ g ground state. Instead, a preference for the ejection of the p + in the direction of the escaping photoelectron can be observed. This symmetry breaking is strongest for very small electron energies. Our experiment is consistent with a recent prediction by Serov and Kheifets. In theirmore » model, which treats the photoelectron classically, the symmetry breaking is induced by the retroaction of the long-range Coulomb potential onto the dissociating H 2 +.« less

Neural, Cellular and Molecular Mechanisms of Active Forgetting

PubMed Central

Medina, Jorge H.

2018-01-01

The neurobiology of memory formation attracts much attention in the last five decades. Conversely, the rules that govern and the mechanisms underlying forgetting are less understood. In addition to retroactive interference, retrieval-induced forgetting and passive decay of time, it has been recently demonstrated that the nervous system has a diversity of active and inherent processes involved in forgetting. In Drosophila, some operate mainly at an early stage of memory formation and involves dopamine (DA) neurons, specific postsynaptic DA receptor subtypes, Rac1 activation and induces rapid active forgetting. In mammals, others regulate forgetting and persistence of seemingly consolidated memories and implicate the activity of DA receptor subtypes and AMPA receptors in the hippocampus (HP) and related structures to activate parallel signaling pathways controlling active time-dependent forgetting. Most of them may involve plastic changes in synaptic and extrasynaptic receptors including specific removal of GluA2 AMPA receptors. Forgetting at longer timescales might also include changes in adult neurogenesis in the dentate gyrus (DG) of the HP. Therefore, based on relevance or value considerations neuronal circuits may regulate in a time-dependent manner what is formed, stored, and maintained and what is forgotten. PMID:29467630

Task-relevant perceptual features can define categories in visual memory too.

PubMed

Antonelli, Karla B; Williams, Carrick C

2017-11-01

Although Konkle, Brady, Alvarez, and Oliva (2010, Journal of Experimental Psychology: General, 139(3), 558) claim that visual long-term memory (VLTM) is organized on underlying conceptual, not perceptual, information, visual memory results from visual search tasks are not well explained by this theory. We hypothesized that when viewing an object, any task-relevant visual information is critical to the organizational structure of VLTM. In two experiments, we examined the organization of VLTM by measuring the amount of retroactive interference created by objects possessing different combinations of task-relevant features. Based on task instructions, only the conceptual category was task relevant or both the conceptual category and a perceptual object feature were task relevant. Findings indicated that when made task relevant, perceptual object feature information, along with conceptual category information, could affect memory organization for objects in VLTM. However, when perceptual object feature information was task irrelevant, it did not contribute to memory organization; instead, memory defaulted to being organized around conceptual category information. These findings support the theory that a task-defined organizational structure is created in VLTM based on the relevance of particular object features and information.

Kline DeWire Public Safety Officers' Retroactive Benefits Act

THOMAS, 113th Congress

Rep. Marino, Tom [R-PA-10

2014-04-29

House - 07/21/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Federal Employee Retroactive Pay Fairness Act

THOMAS, 113th Congress

Sen. Cardin, Benjamin L. [D-MD

2013-10-01

Senate - 10/01/2013 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Federal Employee Retroactive Pay Fairness Act

THOMAS, 112th Congress

Rep. Moran, James P. [D-VA-8

2011-04-07

House - 04/08/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Federal Employee Retroactive Pay Fairness Act

THOMAS, 113th Congress

Rep. Moran, James P. [D-VA-8

2013-09-30

Senate - 10/07/2013 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 208. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

20 CFR 416.1210 - Exclusions from resources; general.

Code of Federal Regulations, 2014 CFR

2014-04-01

... is required by such statute; (k) Disaster relief assistance as provided in § 416.1237; (l) Burial... title II retroactive payments as provided in § 416.1233; (n) Housing assistance as provided in § 416...

20 CFR 416.1210 - Exclusions from resources; general.

Code of Federal Regulations, 2012 CFR

2012-04-01

... is required by such statute; (k) Disaster relief assistance as provided in § 416.1237; (l) Burial... title II retroactive payments as provided in § 416.1233; (n) Housing assistance as provided in § 416...

20 CFR 416.1210 - Exclusions from resources; general.

Code of Federal Regulations, 2010 CFR

2010-04-01

... is required by such statute; (k) Disaster relief assistance as provided in § 416.1237; (l) Burial... title II retroactive payments as provided in § 416.1233; (n) Housing assistance as provided in § 416...

20 CFR 416.1210 - Exclusions from resources; general.

Code of Federal Regulations, 2011 CFR

2011-04-01

... is required by such statute; (k) Disaster relief assistance as provided in § 416.1237; (l) Burial... title II retroactive payments as provided in § 416.1233; (n) Housing assistance as provided in § 416...

5 CFR 831.1805 - Creditor agency processing for non-fraud claims.

Code of Federal Regulations, 2010 CFR

2010-01-01

... from any final payments (salary, accrued annual leave, etc.) due the debtor. If a balance is due after... (retroactive collection limited to 6 months of premiums); or (iv) Overpaid military retired pay an annuitant...

20 CFR 418.3425 - What resources do we exclude from counting?

Code of Federal Regulations, 2014 CFR

2014-04-01

... under a Federal statute where exclusion is required by such statute; (i) Disaster relief assistance as... title II retroactive payments as provided in § 416.1233 of this chapter; (m) Housing assistance as...

20 CFR 418.3425 - What resources do we exclude from counting?

Code of Federal Regulations, 2012 CFR

2012-04-01

... under a Federal statute where exclusion is required by such statute; (i) Disaster relief assistance as... title II retroactive payments as provided in § 416.1233 of this chapter; (m) Housing assistance as...

20 CFR 418.3425 - What resources do we exclude from counting?

Code of Federal Regulations, 2011 CFR

2011-04-01

... under a Federal statute where exclusion is required by such statute; (i) Disaster relief assistance as... title II retroactive payments as provided in § 416.1233 of this chapter; (m) Housing assistance as...

20 CFR 418.3425 - What resources do we exclude from counting?

Code of Federal Regulations, 2013 CFR

2013-04-01

... under a Federal statute where exclusion is required by such statute; (i) Disaster relief assistance as... title II retroactive payments as provided in § 416.1233 of this chapter; (m) Housing assistance as...

Medicare changes create accounting, reporting, and auditing problems. Task Force on Federal Health Care Legislation, American Institute of Certified Public Accountants.

PubMed

1984-11-01

Hospital auditors and financial officers must adjust and react to the changing financial healthcare environment brought about by PPS. A close review of accounting systems, reporting methods, auditing procedures, and internal control systems should be made to determine that assets are safe-guarded and financial information is presented in conformity with GAAP. This article identified new problems and suggested solutions. Old tasks may no longer be necessary. For example, retroactive adjustments are not as important as they used to be. Estimates for capital and outpatient costs may continue to be required, but elaborate cost-finding techniques may no longer be necessary to estimate retroactive adjustments for reimbursable items. We recommend that prior to beginning an audit of a hospital's financial statements, each hospital's financial officers and its auditors discuss the possible accounting, reporting, and auditing implications as a result of PPS.

Cleanup liability and the Constitution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedland, D.M.; Hagen, P.E.

It was observed in the July 1992 issue of this Journal that a plain reading of the Constitution's prohibition on [open quotes][ital ex post facto][close quotes] suggests that some environmental statutes such as the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) and the Resource Conservation and Recovery Act of 1976 (RCRA) conflict with Constitutional principles. Like many Constitutional principles, however, the Supreme Court's interpretation of the Constitution's bar on [ital ex post facto] laws has a long history. The Court has consistently interpreted this clause as limited to criminal or penal statutes. This article discussesmore » the history of the [ital ex post facto] clause, the retroactive application of CERCLA and RCRA, the decision that retroactive application of CERCLA and RCRA does not violate the [ital ex post facto] clause, and laws, regulations, and guidance. 27 refs.« less

42 CFR 495.362 - Retroactive approval of FFP with an effective date of February 18, 2009.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to the Medicaid Program § 495.362... payments to providers, a State may request consideration of FFP by recorded request in a HIT advance...

Retroactive Stop Loss Special Pay

Science.gov Websites

earned this money. It doesn't matter whether you were Active or Reserve, whether you're a veteran who organizations, and the media. But there is still money left to be claimed, and the deadline is approaching. The

Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials.

PubMed

DeVincenzo, John P

2009-10-01

A revolution in the understanding of RNA biological processing and control is leading to revolutionary new concepts in human therapeutics. It has become increasingly clear that the so called "non-coding RNA" exerts specific and profound functional control on regulation of protein production and indeed controls the expression of all genes. Harnessing this naturally-occurring RNA-mediated regulation of protein production has immense human therapeutic potential. These processes are collectively known as RNA interference (RNAi). RNAi is a recently discovered, naturally-occurring intracellular process that regulates gene expression through the silencing of specific mRNAs. Methods of harnessing this natural pathway are being developed that allow the catalytic degradation of targeted mRNAs using specifically designed complementary small inhibitory RNAs (siRNA). siRNAs are being chemically modified to acquire drug-like properties. Numerous recent high profile publications have provided proofs of concept that RNA interference may be useful therapeutically. Much of the design of these siRNAs can be accomplished bioinformatically, thus potentially expediting drug discovery and opening new avenues of therapy for many uncommon, orphan, or emerging diseases. This makes this approach very attractive for developing therapies targeting orphan diseases including neonatal diseases. Theoretically, any disease that can be ameliorated through knockdown of any endogenous or exogenous protein is a potential therapeutic target for RNAi-based therapeutics. Lung diseases are particularly attractive targets for RNAi therapeutics since the affected cells' location increases their accessibility to topical administration of siRNA, for example by aerosol. Respiratory viral infections and chronic lung disease are examples of such diseases. RNAi therapeutics have been shown to be active against RSV, parainfluenza and human metapneumoviruses in vitro and in vivo resulting in profound antiviral effects. The first proof of concept test of efficacy of an RNAi-based therapeutic in man has been initiated. A discussion of the science behind RNA interference is followed by a presentation of the potential practical issues in applying this technology to neonatal respiratory viral diseases. RNAi may offer new strategies for the treatment of a variety of orphan diseases including neonatal diseases, RSV infections, and other respiratory viruses.

42 CFR 423.466 - Timeframes for coordination of benefits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 423.466 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Coordination of Part D...) Retroactive claims adjustments, underpayment refunds, and overpayment recoveries. Whenever a sponsor receives...

44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... adoption of a generally applicable State or local law, ordinance or wage order or a cost-of-living... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such a...

44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... adoption of a generally applicable State or local law, ordinance or wage order or a cost-of-living... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such a...

44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... adoption of a generally applicable State or local law, ordinance or wage order or a cost-of-living... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such a...

44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... adoption of a generally applicable State or local law, ordinance or wage order or a cost-of-living... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such a...

44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... adoption of a generally applicable State or local law, ordinance or wage order or a cost-of-living... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such a...

29 CFR 452.54 - Retroactive rules.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS GENERAL STATEMENT CONCERNING THE ELECTION PROVISIONS OF THE LABOR-MANAGEMENT REPORTING AND DISCLOSURE ACT... of the requirement. It would be unreasonable for a labor organization to enforce eligibility...

29 CFR 452.54 - Retroactive rules.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS GENERAL STATEMENT CONCERNING THE ELECTION PROVISIONS OF THE LABOR-MANAGEMENT REPORTING AND DISCLOSURE ACT... of the requirement. It would be unreasonable for a labor organization to enforce eligibility...

A Posthypnotic Amnesia: Suggestions of an Active Process in Dissociative Phenomena

ERIC Educational Resources Information Center

Coe, William C.; And Others

1976-01-01

A retroactive inhibition design was used to examine the process of posthypnotic amnesia. The results supported the notion that "forgotten" material is as available to amnesic subjects at some level as it is to nonamnesic subjects. (Editor)

76 FR 6319 - Designation of Biobased Items for Federal Procurement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... to have retroactive effect, and does not involve administrative appeals. D. Executive Order 13132... at: http://www.biopreferred.gov . * * * (b) Advertising, labeling and marketing claims. Manufacturers and vendors are reminded that their advertising, labeling, and other marketing claims, including...

Carrier-envelope phase-dependent atomic coherence and quantum beats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu Ying; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071; Yang Xiaoxue

2007-07-15

It is shown that the carrier-envelope phase (CEP) of few-cycle laser pulses has profound effects on the bound-state atomic coherence even in the weak-field regime where both tunneling and multiphoton ionization hardly take place. The atomic coherence thus produced is shown to be able to be mapped onto the CEP-dependent signal of quantum beats (and other quantum-interference phenomena) and hence might be used to extract information about and ultimately to measure the carrier-envelope phase.

5 CFR 890.103 - Correction of errors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Administration and General Provisions § 890.103... States Code, and permit the individual to enroll in another health benefits plan for purposes of this... health care providers. (e) Retroactive corrections are subject to withholdings and contributions under...

32 CFR 279.6 - Reporting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS RETROACTIVE STOP LOSS SPECIAL PAY COMPENSATION § 279.6 Reporting. The Department of Defense shall provide a consolidated report to the congressional defense committees on the implementation of section 310 of Public Law...

32 CFR 279.6 - Reporting.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS RETROACTIVE STOP LOSS SPECIAL PAY COMPENSATION § 279.6 Reporting. The Department of Defense shall provide a consolidated report to the congressional defense committees on the implementation of section 310 of Public Law...

New EU ETS Phase 4 rules temporarily puncture waterbed

NASA Astrophysics Data System (ADS)

Perino, Grischa

2018-04-01

The new rules of the EU ETS will fundamentally change its character. The long-term cap on emissions will become a function of past and future market outcomes, temporarily puncturing the waterbed and having retroactive impacts on GHG abatement from overlapping policies.

Court Reaffirms TIAA Must Pay Equal Pensions.

ERIC Educational Resources Information Center

Fields, Cheryl M.

1984-01-01

A second court decision supporting the payment of equal retirement pensions to men and women through the Teachers Insurance Annuities Association and College Retirement Equities Fund for retirees, effective after May 1, 1980, is discussed. This federal appeals court decision allows limited retroactivity. (MSE)

20 CFR 404.1276 - Reports and payments erroneously made to Internal Revenue Service-transfer of funds-for wages...

Code of Federal Regulations, 2010 CFR

2010-04-01

... limitations remain on the earnings records. (e) Filing wage reports and paying contributions. Generally, the... regular modification cannot be used (e.g., State law does not permit the retroactive effective date which...

7 CFR 1485.17 - Reimbursement rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... to receive the promotional item; (12) The design and production of packaging, labeling or origin...) The design, production, and distribution of coupons for products other than the MAP Participant's... shall document by a salary survey or other means, except for approved supergrades; (4) A retroactive...

19 CFR 10.625 - Refunds of excess customs duties.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-Central America-United States Free Trade Agreement Retroactive Preferential Tariff Treatment for Textile... Dominican Republic—Central America—United States Free Trade Agreement Implementation Act, as amended by... 10.625 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT...

Automatic decomposition of kinetic models of signaling networks minimizing the retroactivity among modules.

PubMed

Saez-Rodriguez, Julio; Gayer, Stefan; Ginkel, Martin; Gilles, Ernst Dieter

2008-08-15

The modularity of biochemical networks in general, and signaling networks in particular, has been extensively studied over the past few years. It has been proposed to be a useful property to analyze signaling networks: by decomposing the network into subsystems, more manageable units are obtained that are easier to analyze. While many powerful algorithms are available to identify modules in protein interaction networks, less attention has been paid to signaling networks de.ned as chemical systems. Such a decomposition would be very useful as most quantitative models are de.ned using the latter, more detailed formalism. Here, we introduce a novel method to decompose biochemical networks into modules so that the bidirectional (retroactive) couplings among the modules are minimized. Our approach adapts a method to detect community structures, and applies it to the so-called retroactivity matrix that characterizes the couplings of the network. Only the structure of the network, e.g. in SBML format, is required. Furthermore, the modularized models can be loaded into ProMoT, a modeling tool which supports modular modeling. This allows visualization of the models, exploiting their modularity and easy generation of models of one or several modules for further analysis. The method is applied to several relevant cases, including an entangled model of the EGF-induced MAPK cascade and a comprehensive model of EGF signaling, demonstrating its ability to uncover meaningful modules. Our approach can thus help to analyze large networks, especially when little a priori knowledge on the structure of the network is available. The decomposition algorithms implemented in MATLAB (Mathworks, Inc.) are freely available upon request. ProMoT is freely available at http://www.mpi-magdeburg.mpg.de/projects/promot. Supplementary data are available at Bioinformatics online.

Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits.

PubMed

Aggarwal, Dau Dayal; Rashkovetsky, Eugenia; Michalak, Pawel; Cohen, Irit; Ronin, Yefim; Zhou, Dan; Haddad, Gabriel G; Korol, Abraham B

2015-11-27

Population genetics predicts that tight linkage between new and/or pre-existing beneficial and deleterious alleles should decrease the efficiency of natural selection in finite populations. By decoupling beneficial and deleterious alleles and facilitating the combination of beneficial alleles, recombination accelerates the formation of high-fitness genotypes. This may impose indirect selection for increased recombination. Despite the progress in theoretical understanding, interplay between recombination and selection remains a controversial issue in evolutionary biology. Even less satisfactory is the situation with crossover interference, which is a deviation of double-crossover frequency in a pair of adjacent intervals from the product of recombination rates in the two intervals expected on the assumption of crossover independence. Here, we report substantial changes in recombination and interference in three long-term directional selection experiments with Drosophila melanogaster: for desiccation (~50 generations), hypoxia, and hyperoxia tolerance (>200 generations each). For all three experiments, we found a high interval-specific increase of recombination frequencies in selection lines (up to 40-50% per interval) compared to the control lines. We also discovered a profound effect of selection on interference as expressed by an increased frequency of double crossovers in selection lines. Our results show that changes in interference are not necessarily coupled with increased recombination. Our results support the theoretical predictions that adaptation to a new environment can promote evolution toward higher recombination. Moreover, this is the first evidence of selection for different recombination-unrelated traits potentially leading, not only to evolution toward increased crossover rates, but also to changes in crossover interference, one of the fundamental features of recombination.

7 CFR 1485.17 - Reimbursement rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... shall document by a salary survey or other means, except for approved supergrades; (4) A retroactive..., machinery, removable fixtures, draperies, blinds, floor coverings, computer hardware and software, and..., including communication costs, except as noted in § 1485.17(c)(22) and except that usage costs for...

26 CFR 1.141-0 - Table of contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... long. (3) Fair market value consideration. (4) Disposition proceeds treated as gross proceeds for...) Examples. § 1.141-14 Anti-abuse rules. (a) Authority of Commissioner to reflect substance of transactions... regulations. (e) Permissive retroactive application of certain sections. (f) Effective dates for certain...

26 CFR 1.141-0 - Table of contents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... long. (3) Fair market value consideration. (4) Disposition proceeds treated as gross proceeds for...) Examples. § 1.141-14 Anti-abuse rules. (a) Authority of Commissioner to reflect substance of transactions... regulations. (e) Permissive retroactive application of certain sections. (f) Effective dates for certain...

26 CFR 1.141-0 - Table of contents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... long. (3) Fair market value consideration. (4) Disposition proceeds treated as gross proceeds for...) Examples. § 1.141-14 Anti-abuse rules. (a) Authority of Commissioner to reflect substance of transactions... regulations. (e) Permissive retroactive application of certain sections. (f) Effective dates for certain...

26 CFR 1.141-0 - Table of contents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... long. (3) Fair market value consideration. (4) Disposition proceeds treated as gross proceeds for...) Examples. § 1.141-14 Anti-abuse rules. (a) Authority of Commissioner to reflect substance of transactions... regulations. (e) Permissive retroactive application of certain sections. (f) Effective dates for certain...

24 CFR 888.415 - Restrictions on retroactive payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD, will review whether rents were excessive when initially set. (c) Physical condition of projects. If the most recent physical inspection report by the PHA shows significant deficiencies that have not... to all regulations, procedures, or restrictions that apply to Housing Assistance Payments. (b) Review...

5 CFR 511.701 - Effective dates generally.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Except as provided in § 511.703, classification actions may not be made retroactive. (b) Office of Personnel Management's classification decision. (1) The effective date of a classification decision made by... CLASSIFICATION UNDER THE GENERAL SCHEDULE Effective Dates of Position Classification Actions or Decisions § 511...

5 CFR 511.701 - Effective dates generally.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Except as provided in § 511.703, classification actions may not be made retroactive. (b) Office of Personnel Management's classification decision. (1) The effective date of a classification decision made by... CLASSIFICATION UNDER THE GENERAL SCHEDULE Effective Dates of Position Classification Actions or Decisions § 511...

Retroactive Operations: On "Increments" in Mandarin Chinese Conversations

ERIC Educational Resources Information Center

Lim, Ni Eng

2014-01-01

Conversation Analysis (CA) has established repair (Schegloff, Jefferson & Sacks 1977; Schegloff 1979; Kitzinger 2013) as a conversational mechanism for managing contingencies of talk-in-interaction. In this dissertation, I look at a particular sort of "repair" termed TCU-continuations (or otherwise known increments in other…

26 CFR 1.1295-3 - Retroactive elections.

Code of Federal Regulations, 2010 CFR

2010-04-01

... rules require that the shareholder possess reasonable belief as of the election due date that the... reasonable belief that a foreign corporation was not a PFIC. Paragraph (e) of this section prescribes special rules for certain shareholders that are deemed to satisfy the reasonable belief requirement and...

26 CFR 1.148-11 - Effective dates.

Code of Federal Regulations, 2010 CFR

2010-04-01

... provisions retroactively. (d) Transition rule excepting certain state guarantee funds from the definition of replacement proceeds—(1) Certain perpetual trust funds. A guarantee by a fund created and controlled by a... nonfinancial assets, revenues derived from these assets, gifts, and bequests; (ii) The corpus of the guarantee...

20 CFR 725.608 - Interest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... simple annual interest, computed from the date on which the benefits were due. The interest shall be... payment of retroactive benefits, the beneficiary shall also be entitled to simple annual interest on such... entitled to simple annual interest computed from the date upon which the beneficiary's right to additional...

5 CFR 847.415 - OASDI coverage.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false OASDI coverage. 847.415 Section 847.415...) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections of Coverage Under the Retroactive Provisions Elections of Csrs Or Fers Coverage Based on A Move...

5 CFR 847.415 - OASDI coverage.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false OASDI coverage. 847.415 Section 847.415...) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections of Coverage Under the Retroactive Provisions Elections of Csrs Or Fers Coverage Based on A Move...

5 CFR 847.415 - OASDI coverage.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false OASDI coverage. 847.415 Section 847.415...) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections of Coverage Under the Retroactive Provisions Elections of Csrs Or Fers Coverage Based on A Move...

42 CFR 431.246 - Corrective action.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Corrective action. 431.246 Section 431.246 Public... Recipients Procedures § 431.246 Corrective action. The agency must promptly make corrective payments, retroactive to the date an incorrect action was taken, and, if appropriate, provide for admission or...

42 CFR 431.246 - Corrective action.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Corrective action. 431.246 Section 431.246 Public... Recipients Procedures § 431.246 Corrective action. The agency must promptly make corrective payments, retroactive to the date an incorrect action was taken, and, if appropriate, provide for admission or...

Contingency blindness: location-identity binding mismatches obscure awareness of spatial contingencies and produce profound interference in visual working memory.

PubMed

Fiacconi, Chris M; Milliken, Bruce

2012-08-01

The purpose of the present study was to highlight the role of location-identity binding mismatches in obscuring explicit awareness of a strong contingency. In a spatial-priming procedure, we introduced a high likelihood of location-repeat trials. Experiments 1, 2a, and 2b demonstrated that participants' explicit awareness of this contingency was heavily influenced by the local match in location-identity bindings. In Experiment 3, we sought to determine why location-identity binding mismatches produce such low levels of contingency awareness. Our results suggest that binding mismatches can interfere substantially with visual-memory performance. We attribute the low levels of contingency awareness to participants' inability to remember the critical location-identity binding in the prime on a trial-to-trial basis. These results imply a close interplay between object files and visual working memory.

78 FR 16726 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... Price, Managing Director, Securities Industry and Financial Markets Association, dated October 4, 2012... other industry professionals will have difficulty pricing options during Limit States and Straddle... conditions have changed and (ii) gaming the obvious error rule to retroactively adjust market maker quotes by...

5 CFR 870.505 - Optional insurance: Waiver/cancellation of insurance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... § 870.505 Optional insurance: Waiver/cancellation of insurance. (a) An insured individual may cancel...: an individual who has assigned his/her insurance under subpart I of this part cannot cancel Option A... is cancelled because there are no eligible family members, the effective date is retroactive to the...

26 CFR 1.1295-3 - Retroactive elections.

Code of Federal Regulations, 2011 CFR

2011-04-01

... termination of a pass through entity or pass through entity's business. The complete termination of a pass...'s trade or business, will not terminate a waiver that applies to a partner, shareholder, or... entity or the entity's trade or business. (ii) Terms of waiver—(A) Scope of waiver. The waiver of the...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

28 CFR 545.26 - Performance pay provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... month that the inmate was working. Performance pay may not be awarded retroactively. (d) An inmate is... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Performance pay provisions. 545.26... WORK AND COMPENSATION Inmate Work and Performance Pay Program § 545.26 Performance pay provisions. (a...

26 CFR 509.102 - Applicable provisions of law.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Applicable provisions of law. 509.102 Section... UNDER TAX CONVENTIONS SWITZERLAND General Income Tax § 509.102 Applicable provisions of law. (a) General... reason of any alteration of law in relation to internal revenue. (b) Retroactivity of regulations or...

Cap check helps reconcile payments with eligibility lists to improve cash flow.

PubMed

2003-05-01

Some capitated provider groups are becoming more adept at using software solutions to effectively manage retroactive deletions, additions and changes in membership enrollment. While a variety of software programs are available, several sources recommend using Cap Check to help match up eligibility lists with capitation payment.

5 CFR 847.703 - Reductions in annuity.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Reductions in annuity. 847.703 Section... INSTRUMENTALITIES Computation of Benefits Under the Retroactive Provisions § 847.703 Reductions in annuity. The CSRS or FERS basic annuity of an employee or survivor who has elected retirement coverage under subpart D...

5 CFR 880.204 - Restoration of annuity.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Restoration of annuity. 880.204 Section... Restoration of annuity. (a) If the missing annuitant's whereabouts are determined, and he or she is alive and— (1) Competent, OPM will resume payments to the annuitant and pay retroactive annuity for the period...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2010 CFR

2010-04-01

....338-11 apply to qualified stock purchases occurring on or after April 10, 2006. (2) New target election for retroactive application—(i) Availability of election. New target may make an irrevocable..., 2006 for which a section 338 election is made, provided that new target's first taxable year and all...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2011 CFR

2011-04-01

....338-11 apply to qualified stock purchases occurring on or after April 10, 2006. (2) New target election for retroactive application—(i) Availability of election. New target may make an irrevocable..., 2006 for which a section 338 election is made, provided that new target's first taxable year and all...

Outcomes of a College Wilderness Orientation Program

ERIC Educational Resources Information Center

Lien, Matt; Goldenberg, Marni

2012-01-01

Wilderness orientation programs have been utilized by colleges and universities in the United States for nearly 75 years. This study, using means-end theory, reveals the outcomes of a wilderness orientation program for incoming students. A retroactive study was conducted for all participants who had taken part in a wilderness orientation program…

7 CFR 1485.16 - Reimbursement rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the limitation that CCC will not reimburse more than $1.00 per item; (11) The design and production of... the MAP participant shall document by a salary survey or other means. (4) A retroactive salary... participants for MAP activities or for travel of non-MAP participant personnel; (16) Market research; (17...

5 CFR 847.602 - Present value factors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Present value factors. 847.602 Section... INSTRUMENTALITIES Additional Employee Costs Under the Retroactive Provisions § 847.602 Present value factors. (a... present value factors for all CSRS annuities; (2) One table of present value factors for FERS annuities...

42 CFR 413.64 - Payments to providers: Specific rules.

Code of Federal Regulations, 2013 CFR

2013-10-01

... retroactive adjustment. (g) Accelerated payments to providers. Upon request, an accelerated payment may be... as a percentage of the net reimbursement for unbilled or unpaid covered services. Recovery of the accelerated payment may be made by recoupment as provider bills are processed or by direct payment. (h...

42 CFR 413.64 - Payments to providers: Specific rules.

Code of Federal Regulations, 2012 CFR

2012-10-01

... retroactive adjustment. (g) Accelerated payments to providers. Upon request, an accelerated payment may be... as a percentage of the net reimbursement for unbilled or unpaid covered services. Recovery of the accelerated payment may be made by recoupment as provider bills are processed or by direct payment. (h...

42 CFR 413.64 - Payments to providers: Specific rules.

Code of Federal Regulations, 2011 CFR

2011-10-01

... retroactive adjustment. (g) Accelerated payments to providers. Upon request, an accelerated payment may be... as a percentage of the net reimbursement for unbilled or unpaid covered services. Recovery of the accelerated payment may be made by recoupment as provider bills are processed or by direct payment. (h...

26 CFR 1.411(a)-4 - Forfeitures, suspensions, etc.

Code of Federal Regulations, 2010 CFR

2010-04-01

... account benefits which are provided under the Social Security Act or under any other Federal or State law... retroactive effect in accordance with such section. (4) Other forfeiture rules—(i) Withdrawal of mandatory contributions. For rules allowing forfeitures on account of the withdrawal of mandatory contributions, see § 1...

Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma

PubMed Central

Wong, E T; Lok, E; Gautam, S; Swanson, K D

2015-01-01

Background: Patients with recurrent glioblastoma have a poor outcome. Data from the phase III registration trial comparing tumour-treating alternating electric fields (TTFields) vs chemotherapy provided a unique opportunity to study dexamethasone effects on patient outcome unencumbered by the confounding immune and myeloablative side effects of chemotherapy. Methods: Using an unsupervised binary partitioning algorithm, we segregated both cohorts of the trial based on the dexamethasone dose that yielded the greatest statistical difference in overall survival (OS). The results were validated in a separate cohort treated in a single institution with TTFields and their T lymphocytes were correlated with OS. Results: Patients who used dexamethasone doses >4.1 mg per day had a significant reduction in OS when compared with those who used ⩽4.1 mg per day, 4.8 vs 11.0 months respectively (χ2=34.6, P<0.0001) in the TTField-treated cohort and 6.0 vs 8.9 months respectively (χ2=10.0, P<0.0015) in the chemotherapy-treated cohort. In a single institution validation cohort treated with TTFields, the median OS of patients who used dexamethasone >4.1 mg per day was 3.2 months compared with those who used ⩽4.1 mg per day was 8.7 months (χ2=11.1, P=0.0009). There was a significant correlation between OS and T-lymphocyte counts. Conclusions: Dexamethasone exerted profound effects on both TTFields and chemotherapy efficacy resulting in lower patient OS. Therefore, global immunosuppression by dexamethasone likely interferes with immune functions that are necessary for the treatment of glioblastoma. PMID:26125449

Framing the Issue: Religion, Secular Ethics and the Case of Animal Rights Mobilization

ERIC Educational Resources Information Center

Mika, Marie

2006-01-01

This article addresses social movement framing, generally, and within contemporary animal rights movements specifically by conducting focus group analyses of a non-activist population. This contrasts with previous studies of recruitment that have examined the conversion process retroactively, culling data from those already involved in a cause. By…

The Loci Mnemonic Technique in Learning and Memory.

ERIC Educational Resources Information Center

Montague, William E.; Carter, John

This study investigated the facilitative effects of the loci system using mental imagery for acquisition and recall within a retroactive inhibition (RI) paradigm. Fifty-five college undergraduates were randomly assigned to five treatment conditions. Four groups formed cells in a 2x2 factorial design which included (1) an RI factor (AB-AD vs.…

5 CFR 847.605 - Methodology for determining the present value of annuity with service credit.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Retroactive Provisions § 847.605 Methodology for determining the present value of annuity with service credit. (a) OPM will determine the present value of the annuity including service credit for NAFI service..., the present value under paragraph (a) of this section equals the monthly annuity rate including credit...

24 CFR 888.310 - Notice of eligibility requirements for retroactive payments.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., SECTION 202 DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811..., Section 202 Elderly or Handicapped, and Special Allocations Projects § 888.310 Notice of eligibility....301 (a) and (b), and documentation of the occupancy rate for the period from October 1, 1979, to May...

24 CFR 888.310 - Notice of eligibility requirements for retroactive payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., SECTION 202 DIRECT LOAN PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811..., Section 202 Elderly or Handicapped, and Special Allocations Projects § 888.310 Notice of eligibility....301 (a) and (b), and documentation of the occupancy rate for the period from October 1, 1979, to May...

40 CFR 141.133 - Compliance requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... specified by § 141.135(c). Systems may begin monitoring to determine whether Step 1 TOC removals can be met... the Step 1 requirements in § 141.135(b)(2) and must therefore apply for alternate minimum TOC removal (Step 2) requirements, is not eligible for retroactive approval of alternate minimum TOC removal (Step 2...

37 CFR 5.25 - Petition for retroactive license.

Code of Federal Regulations, 2010 CFR

2010-07-01

... invention of a pending application and no petition under § 1.181 has been filed, a final rejection of the..., DEPARTMENT OF COMMERCE GENERAL SECRECY OF CERTAIN INVENTIONS AND LICENSES TO EXPORT AND FILE APPLICATIONS IN... be renewed. Failure to renew the petition within the set time period will result in a final denial of...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 27.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... occupant must be protected from serious head injury by a safety belt plus a shoulder harness that will... seat is equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (1) Each occupant's seat must have a combined safety belt and shoulder...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

Retroactive maintains cuticle integrity by promoting the trafficking of Knickkopf into the procuticle of Tribolium castaneum

USDA-ARS?s Scientific Manuscript database

Molting, or the replacement of the old exoskeleton with a new cuticle, is a complex developmental process that all insects must undergo to maintain growth. Our work has uncovered a major pathway involved in cuticular chitin maintenance wherein accumulation of the Tribolium castaneum knickkopf protei...

77 FR 5414 - Fisheries of the Northeastern United States; Summer Flounder Fishery; Quota Transfer

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

.... 101029427-0609-02] RIN 0648-XA946 Fisheries of the Northeastern United States; Summer Flounder Fishery... of North Carolina is retroactively transferring a portion of its 2011 commercial summer flounder... INFORMATION: Regulations governing the summer flounder fishery are found at 50 CFR part 648. The regulations...

78 FR 9849 - Fisheries of the Northeastern United States; Summer Flounder Fishery; Quota Transfer

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

.... 111220786-1781-01] RIN 0648-XC451 Fisheries of the Northeastern United States; Summer Flounder Fishery... of North Carolina is retroactively transferring a portion of its 2012 commercial summer flounder... summer flounder fishery are in 50 CFR part 648, and require annual specification of a commercial quota...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2014 CFR

2014-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2012 CFR

2012-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2013 CFR

2013-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

5 CFR 847.304 - Time limit.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Time limit. 847.304 Section 847.304... Procedures for Elections Under the Retroactive Provisions § 847.304 Time limit. (a) Except as provided in paragraph (b) of this section, the time limit for making an election under subpart D of this part is August...

5 CFR 847.304 - Time limit.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Time limit. 847.304 Section 847.304... Procedures for Elections Under the Retroactive Provisions § 847.304 Time limit. (a) Except as provided in paragraph (b) of this section, the time limit for making an election under subpart D of this part is August...

5 CFR 847.304 - Time limit.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Time limit. 847.304 Section 847.304... Procedures for Elections Under the Retroactive Provisions § 847.304 Time limit. (a) Except as provided in paragraph (b) of this section, the time limit for making an election under subpart D of this part is August...

The Wender Utah Rating Scale: Adult ADHD Diagnostic Tool or Personality Index?

ERIC Educational Resources Information Center

Hill, B.D.; Pella, Russell D.; Singh, Ashvind N.; Jones, Glenn N.; Gouvier, Wm. Drew

2009-01-01

Objective: The Wender Utah Rating Scale (WURS) is used to retroactively assess ADHD symptoms. This study sought to determine whether the WURS actually functions as an index of dysfunctional personality traits. Method: Five hundred twenty-two adult participants completed the WURS and at least one of the following measures: Wechsler Adult…

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

77 FR 51867 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... supplemental assessments collected for use by the Cotton Research and Promotion Program. An amendment is..., Chief, Research and Promotion Staff, Cotton and Tobacco Programs, AMS, USDA, 100 Riverside Parkway... not intended to have retroactive effect. The Cotton Research and Promotion Act (7 U.S.C. 2101-2118...

5 CFR 532.705 - Appeal to the Office of Personnel Management.

Code of Federal Regulations, 2011 CFR

2011-01-01

... that the employee has left the job, except when entitled to retroactive benefits, including benefits... that: (1) New and material evidence is available that was not readily available when the previous... involving a new or unreviewed policy consideration that may have effects beyond the actual case at hand, or...

Standardization of milk infrared spectra for the retroactive application of calibration models.

PubMed

Bonfatti, V; Fleming, A; Koeck, A; Miglior, F

2017-03-01

The objective of this study was to standardize the infrared spectra obtained over time and across 2 milk laboratories of Canada to create a uniform historical database and allow (1) the retroactive application of calibration models for prediction of fine milk composition; and (2) the direct use of spectral information for the development of indicators of animal health and efficiency. Spectral variation across laboratories and over time was inspected by principal components analysis (PCA). Shifts in the PCA scores were detected over time, leading to the definition of different subsets of spectra having homogeneous infrared signal. To evaluate the possibility of using common equations on spectra collected by the 2 instruments and over time, we developed a standardization (STD) method. For each subset of data having homogeneous infrared signal, a total of 99 spectra corresponding to the percentiles of the distribution of the absorbance at each wavenumber were created and used to build the STD matrices. Equations predicting contents of saturated fatty acids, short-chain fatty acids, and C18:0 were created and applied on different subsets of spectra, before and after STD. After STD, bias and root mean squared error of prediction decreased by 66% and 32%, respectively. When calibration equations were applied to the historical nonstandardized database of spectra, shifts in the predictions could be observed over time for all investigated traits. Shifts in the distribution of the predictions over time corresponded to the shifts identified by the inspection of the PCA scores. After STD, shifts in the predicted fatty acid contents were greatly reduced. Standardization reduced spectral variability between instruments and over time, allowing the merging of milk spectra data from different instruments into a common database, the retroactive use of calibrations equations, or the direct use of the spectral data without restrictions. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

29 CFR 825.212 - Employee failure to pay health plan premium payments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.212 Employee failure to pay health plan premium payments. (a)(1) In... unpaid leave that provide for the employer to cease coverage retroactively to the date the unpaid premium...

29 CFR 825.212 - Employee failure to pay health plan premium payments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.212 Employee failure to pay health plan premium payments. (a)(1) In... unpaid leave that provide for the employer to cease coverage retroactively to the date the unpaid premium...

29 CFR 825.212 - Employee failure to pay health plan premium payments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.212 Employee failure to pay health plan premium payments. (a)(1) In... unpaid leave that provide for the employer to cease coverage retroactively to the date the unpaid premium...

29 CFR 825.212 - Employee failure to pay health plan premium payments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.212 Employee failure to pay health plan premium payments. (a)(1) In... unpaid leave that provide for the employer to cease coverage retroactively to the date the unpaid premium...

Japanese Women's Perceptions of Intimate Partner Violence (IPV)

ERIC Educational Resources Information Center

Nagae, Miyoko; Dancy, Barbara L.

2010-01-01

Intimate partner violence (IPV) is a problem in Japan. The purpose is to describe IPV as perceived by a purposive sample of 11 Japanese adult females who were in a heterosexual marriage at the time of IPV. We used a cross-sectional, retroactive, qualitative description research design with individual, fact-to-face in depth interviews. At the time…

20 CFR 667.825 - What special rules apply to reviews of NFJP and WIA INA grant selections?

Code of Federal Regulations, 2010 CFR

2010-04-01

... current grant cycle. Neither retroactive nor immediately effective selection status may be awarded as... have not been expended by the current grantee through its operation of the grant and its subsequent... the immediately subsequent two-year grant cycle. In such a situation, we will not issue a waiver of...

Operation JUBILEE: Dieppe 1942 - The Myth of Retro-Active Success

DTIC Science & Technology

2012-03-06

what I was saying even if I did not. I would also like to thank my dogs . As oddly as that sounds, as much as I bemoaned having to take them out...As a matter of fact, many are simple regurgitations of lessons previously learned and apparently forgotten, only to be repackaged and reissued as

77 FR 42276 - Certain Cased Pencils From the People's Republic of China: Initiation and Preliminary Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... scope of the order are mechanical pencils, cosmetic pencils, pens, non-cased crayons (wax), pastels... circumference, composed of turned wood encasing one-and-one half inches of sharpened lead on one end and a... Circumstances Review and Determination to Revoke Order in Part, 74 FR 8506 (February 25, 2009) (retroactively...

A Test of the Paired-Associate Analogy to RI in Free Recall.

ERIC Educational Resources Information Center

Perlmutter, Jane; Royer, James M.

To provide a further test of the paired-associate analogy to retroactive inhibition in free recall, this experiment investigated the effect of presenting both original learning (OL) and interpolated learning (IL) in either blocked category (B) or random (R) fashion. IL-OL Similar (S), IL-OL Different (D), and control (C) conditions were included.…

26 CFR 1.197-1T - Certain elections for intangible property (temporary).

Code of Federal Regulations, 2011 CFR

2011-04-01

... retroactive election under paragraph (c)(6) of this section, identification of such persons and certification...) Identification of the property affected by the binding contract election, the name and TIN of the person from... purposes of re-applying the rule of this paragraph (c)(1)(ii) to any other taxpayer. (iii) On former...

Reward Retroactively Enhances Memory Consolidation for Related Items

ERIC Educational Resources Information Center

Patil, Anuya; Murty, Vishnu P.; Dunsmoor, Joseph E.; Phelps, Elizabeth A.; Davachi, Lila

2017-01-01

Reward motivation has been shown to modulate episodic memory processes in order to support future adaptive behavior. However, for a memory system to be truly adaptive, it should enhance memory for rewarded events as well as for neutral events that may seem inconsequential at the time of encoding but can gain importance later. Here, we investigated…

Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays.

PubMed

Trambas, Christina; Lu, Zhong; Yen, Tina; Sikaris, Ken

2018-03-01

Background Biotin interference is a significant problem to which at-risk laboratories must now be attuned. We sought to systematically characterize the nature of this interference in Roche immunoassays. Methods Known concentrations of biotin were titrated into serum samples and the effects on competitive and sandwich immunoassays were analysed. The maximum and minimum concentrations examined reflect those likely to be achieved in individuals on 5 to 10 mg supplements at the lower end, and 100 to 300 mg biotin at the high end. Results A high variability in biotin tolerance was observed. Some assays, such as troponin T, TSH and antithyroid antibodies, were extremely sensitive to the lower concentrations of biotin (15.6 and 31.3 ng/mL), whereas the majority of assays were relatively resistant. At concentrations ≥500 ng/mL, all assays showed significant interference from biotin but, again, the magnitude of the interference was variable. The more sensitive assays showed profound analytical bias at biotin concentrations that occur with high-dose therapy. Conclusion Our data demonstrate high variability in biotin tolerance across Roche immunoassays. The shape of the dose-response curves provides more detailed information than the single manufacturer-quoted figure for biotin tolerance. Accordingly, these data may be used by laboratories for more accurate risk assessment in predicting the effects of biotin. Our data may also be extrapolated to guide timing of blood tests in patients on high-dose biotin therapy: it demonstrates the number of half-lives required to withhold biotin in order to decrease its concentration to below a given assay tolerance.

Error Detection and Self-Assessment as Mechanisms to Promote Self-Regulation of Learning among Secondary Education Students

ERIC Educational Resources Information Center

Zamora, Ángela; Suárez, José Manuel; Ardura, Diego

2018-01-01

The authors' objective was to study the role of error detection and retroactive self-regulation as determinants of performance in secondary education students. A total of 198 students participated in the quasiexperimental study, which involved a control group and two experimental groups. This enabled the authors to analyze the effects of both…

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Code of Federal Regulations, 2014 CFR

2014-04-01

... be designated retroactively as capital gain dividends. (k) Effective date. (b) Scope—(1) In general... currency loss. (2) Net foreign currency loss. (3) Foreign currency gain or loss. (e) Limitation on capital gain dividends. (1) In general. (2) Amount taken into account in current year. (i) Net capital loss...

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Code of Federal Regulations, 2012 CFR

2012-04-01

... be designated retroactively as capital gain dividends. (k) Effective date. (b) Scope—(1) In general... currency loss. (2) Net foreign currency loss. (3) Foreign currency gain or loss. (e) Limitation on capital gain dividends. (1) In general. (2) Amount taken into account in current year. (i) Net capital loss...

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Code of Federal Regulations, 2011 CFR

2011-04-01

... be designated retroactively as capital gain dividends. (k) Effective date. (b) Scope—(1) In general... currency loss. (2) Net foreign currency loss. (3) Foreign currency gain or loss. (e) Limitation on capital gain dividends. (1) In general. (2) Amount taken into account in current year. (i) Net capital loss...

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Code of Federal Regulations, 2010 CFR

2010-04-01

... retroactively as capital gain dividends. (k) Effective date. (b) Scope—(1) In general. This section prescribes... loss. (2) Net foreign currency loss. (3) Foreign currency gain or loss. (e) Limitation on capital gain...) Limitation on capital gain dividends. (D) Effect on other years. (iv) Earnings and profits. (v) Receipt by...

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Code of Federal Regulations, 2013 CFR

2013-04-01

... be designated retroactively as capital gain dividends. (k) Effective date. (b) Scope—(1) In general... currency loss. (2) Net foreign currency loss. (3) Foreign currency gain or loss. (e) Limitation on capital gain dividends. (1) In general. (2) Amount taken into account in current year. (i) Net capital loss...

A Comparison of Long- vs. Short-Term Recall of Substance Use and HIV Risk Behaviors.

PubMed

Janssen, Tim; Braciszewski, Jordan M; Vose-O'Neal, Adam; Stout, Robert L

2017-05-01

The Timeline Follow-back (TLFB) questionnaire has become a pre-eminent tool in substance use and human immunodeficiency virus (HIV) risk research, allowing researchers to assess fine-grained changes in risk behavior over long periods. However, data on accuracy of recall over long (12-month) periods are sparse, especially combined data on HIV risk and substance use from post-treatment samples. Studies on the development of substance use and HIV risk stand to benefit from data on the accurate recall of such behavior over longer retroactive spans of time. The present study offers data on the test-retest reliability of current TLFB assessment versus 6- and 12-month delayed TLFB assessment, using a post-treatment sample (n = 50). Long-term reliability of TLFB data on HIV risk was predominantly good to excellent, with 13 of 20 assessed variables in that range. TLFB data on substance use was similar, with 22 of 26 variables resulting in good/excellent reliability. Our findings support the notion that, notable exceptions aside, the TLFB may be effectively used to assess retroactive HIV risk and substance use in periods of 12 months.

Genetic control of cuticle formation during embryonic development of Drosophila melanogaster.

PubMed Central

Ostrowski, Stephen; Dierick, Herman A; Bejsovec, Amy

2002-01-01

The embryonic cuticle of Drosophila melanogaster is deposited by the epidermal epithelium during stage 16 of development. This tough, waterproof layer is essential for maintaining the structural integrity of the larval body. We have characterized mutations in a set of genes required for proper deposition and/or morphogenesis of the cuticle. Zygotic disruption of any one of these genes results in embryonic lethality. Mutant embryos are hyperactive within the eggshell, resulting in a high proportion reversed within the eggshell (the "retroactive" phenotype), and all show poor cuticle integrity when embryos are mechanically devitellinized. This last property results in embryonic cuticle preparations that appear grossly inflated compared to wild-type cuticles (the "blimp" phenotype). We find that one of these genes, krotzkopf verkehrt (kkv), encodes the Drosophila chitin synthase enzyme and that a closely linked gene, knickkopf (knk), encodes a novel protein that shows genetic interaction with the Drosophila E-cadherin, shotgun. We also demonstrate that two other known mutants, grainy head (grh) and retroactive (rtv), show the blimp phenotype when devitellinized, and we describe a new mutation, called zeppelin (zep), that shows the blimp phenotype but does not produce defects in the head cuticle as the other mutations do. PMID:12019232

The Relationship Between Homework Compliance and Therapy Outcomes: An Updated Meta-Analysis.

PubMed

Mausbach, Brent T; Moore, Raeanne; Roesch, Scott; Cardenas, Veronica; Patterson, Thomas L

2010-10-01

The current study was an updated meta-analysis of manuscripts since the year 2000 examining the effects of homework compliance on treatment outcome. A total of 23 studies encompassing 2,183 subjects were included. Results indicated a significant relationship between homework compliance and treatment outcome suggesting a small to medium effect (r = .26; 95% CI = .19-.33). Moderator analyses were conducted to determine the differential effect size of homework on treatment outcome by target symptoms (e.g., depression; anxiety), source of homework rating (e.g., client; therapist), timing of homework rating (e.g., retroactive vs. contemporaneous), and type of homework rating (e.g., Likert; total homeworks completed). Results indicated that effect sizes were robust across target symptoms, but differed by source of homework rating, timing of homework rating, and type of homework rating. Specifically, studies utilizing combined client and therapist ratings of compliance had significantly higher mean effect size relative to those using therapist only assessments and those using objective assessments. Further, studies that rated the percentage of homeworks completed had a significantly lower mean effect size compared to studies using Likert ratings, and retroactive assessments had higher effect size than contemporaneous assessments.

The Relationship Between Homework Compliance and Therapy Outcomes: An Updated Meta-Analysis

PubMed Central

Moore, Raeanne; Roesch, Scott; Cardenas, Veronica; Patterson, Thomas L.

2010-01-01

The current study was an updated meta-analysis of manuscripts since the year 2000 examining the effects of homework compliance on treatment outcome. A total of 23 studies encompassing 2,183 subjects were included. Results indicated a significant relationship between homework compliance and treatment outcome suggesting a small to medium effect (r = .26; 95% CI = .19–.33). Moderator analyses were conducted to determine the differential effect size of homework on treatment outcome by target symptoms (e.g., depression; anxiety), source of homework rating (e.g., client; therapist), timing of homework rating (e.g., retroactive vs. contemporaneous), and type of homework rating (e.g., Likert; total homeworks completed). Results indicated that effect sizes were robust across target symptoms, but differed by source of homework rating, timing of homework rating, and type of homework rating. Specifically, studies utilizing combined client and therapist ratings of compliance had significantly higher mean effect size relative to those using therapist only assessments and those using objective assessments. Further, studies that rated the percentage of homeworks completed had a significantly lower mean effect size compared to studies using Likert ratings, and retroactive assessments had higher effect size than contemporaneous assessments. PMID:20930925

ORNL Resolved Resonance Covariance Generation for ENDF/B-VII.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leal, Luiz C.; Guber, Klaus H.; Wiarda, Dorothea

2012-12-01

Resonance-parameter covariance matrix (RPCM) evaluations in the resolved resonance regionwere done at the Oak Ridge National Laboratory (ORNL) for the chromium isotopes, titanium isotopes, 19F, 58Ni, 60Ni, 35Cl, 37Cl, 39K, 41K, 55Mn, 233U, 235U, 238U, and 239Pu using the computer code SAMMY. The retroactive approach of the code SAMMY was used to generate the RPCMs for 233U. For 235U, the approach used for covariance generation was similar to the retroactive approach with the distinction that real experimental data were used as opposed to data generated from the resonance parameters. RPCMs for 238U and 239Pu were generated together with the resonancemore » parameter evaluations. The RPCMs were then converted in the ENDF format using the FILE32 representation. Alternatively, for computer storage reasons, the FILE32 was converted in the FILE33 cross section covariance matrix (CSCM). Both representations were processed using the computer code PUFF-IV. This paper describes the procedures used to generate the RPCM and CSCM in the resonance region for ENDF/B-VII.1. The impact of data uncertainty in nuclear reactor benchmark calculations is also presented.« less

Retroactive Maintains Cuticle Integrity by Promoting the Trafficking of Knickkopf into the Procuticle of Tribolium castaneum

PubMed Central

Chaudhari, Sujata S.; Arakane, Yasuyuki; Specht, Charles A.; Moussian, Bernard; Kramer, Karl J.; Muthukrishnan, Subbaratnam; Beeman, Richard W.

2013-01-01

Molting, or the replacement of the old exoskeleton with a new cuticle, is a complex developmental process that all insects must undergo to allow unhindered growth and development. Prior to each molt, the developing new cuticle must resist the actions of potent chitinolytic enzymes that degrade the overlying old cuticle. We recently disproved the classical dogma that a physical barrier prevents chitinases from accessing the new cuticle and showed that the chitin-binding protein Knickkopf (Knk) protects the new cuticle from degradation. Here we demonstrate that, in Tribolium castaneum, the protein Retroactive (TcRtv) is an essential mediator of this protective effect of Knk. TcRtv localizes within epidermal cells and specifically confers protection to the new cuticle against chitinases by facilitating the trafficking of TcKnk into the procuticle. Down-regulation of TcRtv resulted in entrapment of TcKnk within the epidermal cells and caused molting defects and lethality in all stages of insect growth, consistent with the loss of TcKnk function. Given the ubiquity of Rtv and Knk orthologs in arthropods, we propose that this mechanism of new cuticle protection is conserved throughout the phylum. PMID:23382702

Retroactive maintains cuticle integrity by promoting the trafficking of Knickkopf into the procuticle of Tribolium castaneum.

PubMed

Chaudhari, Sujata S; Arakane, Yasuyuki; Specht, Charles A; Moussian, Bernard; Kramer, Karl J; Muthukrishnan, Subbaratnam; Beeman, Richard W

2013-01-01

Molting, or the replacement of the old exoskeleton with a new cuticle, is a complex developmental process that all insects must undergo to allow unhindered growth and development. Prior to each molt, the developing new cuticle must resist the actions of potent chitinolytic enzymes that degrade the overlying old cuticle. We recently disproved the classical dogma that a physical barrier prevents chitinases from accessing the new cuticle and showed that the chitin-binding protein Knickkopf (Knk) protects the new cuticle from degradation. Here we demonstrate that, in Tribolium castaneum, the protein Retroactive (TcRtv) is an essential mediator of this protective effect of Knk. TcRtv localizes within epidermal cells and specifically confers protection to the new cuticle against chitinases by facilitating the trafficking of TcKnk into the procuticle. Down-regulation of TcRtv resulted in entrapment of TcKnk within the epidermal cells and caused molting defects and lethality in all stages of insect growth, consistent with the loss of TcKnk function. Given the ubiquity of Rtv and Knk orthologs in arthropods, we propose that this mechanism of new cuticle protection is conserved throughout the phylum.

Early dynamics of the semantic priming shift

PubMed Central

Lavigne, Frédéric; Chanquoy, Lucile; Dumercy, Laurent; Vitu, Françoise

2013-01-01

Semantic processing of sequences of words requires the cognitive system to keep several word meanings simultaneously activated in working memory with limited capacity. The real- time updating of the sequence of word meanings relies on dynamic changes in the associates to the words that are activated. Protocols involving two sequential primes report a semantic priming shift from larger priming of associates to the first prime to larger priming of associates to the second prime, in a range of long SOAs (stimulus-onset asynchronies) between the second prime and the target. However, the possibility for an early semantic priming shift is still to be tested, and its dynamics as a function of association strength remain unknown. Three multiple priming experiments are proposed that cross-manipulate association strength between each of two successive primes and a target, for different values of short SOAs and prime durations. Results show an early priming shift ranging from priming of associates to the first prime only to priming of strong associates to the first prime and all of the associates to the second prime. We investigated the neural basis of the early priming shift by using a network model of spike frequency adaptive cortical neurons (e.g., Deco & Rolls, 2005), able to code different association strengths between the primes and the target. The cortical network model provides a description of the early dynamics of the priming shift in terms of pro-active and retro-active interferences within populations of excitatory neurons regulated by fast and unselective inhibitory feedback. PMID:23717346

PubMed Central

MUZZI, E.; MARCHI, R.; FALZONE, C.; BATTELINO, S.; CICIRIELLO, E.

2016-01-01

SUMMARY Cochlear implantation (CI) is a viable option for providing access to auditory stimulation in severe-to-profound hearing loss/impairment of cochlear origin. It has been demonstrated that CI is safe and effective for deaf children. Younger age at activation after CI is linked with better outcomes. It is important to study variables and issues that can interfere with an early fitting and access to sound after CI. They range from patient characteristics, family compliance and support, to technical, medical or organisational problems. A SWOT analysis and a subsequent TOWS matrix was conducted to discuss issues and propose recommendations to be considered when operating an early switch on of the CI. PMID:27054390

The Talbot effect in a metamaterial

NASA Astrophysics Data System (ADS)

Nikkhah, H.; Hasan, M.; Hall, T. J.

2018-02-01

The effect of anisotropy and spatial dispersion of a metamaterial on the Talbot effect may be engineered in principle. This has profound implications for applications of the Talbot effect such as the design of a multimode interference coupler (MMI). The paper describes how a metamaterial can suppress the modal phase error which otherwise limits the scaling of MMI port dimension. A binary multilayer dielectric material described by the Kronig-Penney model is shown to provide a close approximation to the required dispersion relation. Results of simulations of a multi-slotted waveguide MMI engineered to provide a polarising beam splitter function are given as an example of the method.

31 CFR 540.202 - Effect of transfers violating the provisions of this part.

Code of Federal Regulations, 2010 CFR

2010-07-01

... pursuant to § 540.201(a) is null and void and shall not be the basis for the assertion or recognition of... discretion, retroactively license a transfer of property that is null and void or unenforceable by virtue of the provisions of this section so that such a transfer shall not be deemed to be null and void or...

Intertwined effects of gender and migration status on persistence in SET study programmes

NASA Astrophysics Data System (ADS)

Guenther, Elisabeth Anna; Koeszegi, Sabine Theresia

2017-11-01

This paper explores the intersectional interference of gender and migration status on students' persistence at an Austrian University of Technology. While controlling for the pre-university education and performance indicators, we estimate the odds for the persistence of male and female students, as well as of students with diverse migration statuses. We use the enrolment data of students from 1998 to 2010. The analysis reveals remarkable and significant effects of gender and migration status, as well as intersectional interference effects from both social categories on persistence. Female and students with immigration status are less likely to persist, even if performance and previous relevant experiences are controlled. A segregated analysis of the student population sheds further light on the interlocked and entangled effects of the social ascriptions underlying gender and migration status. The analysis supports the proposition of the accumulation of (dis-)advantages along students' careers. The profound quantification of gender and migration status effects can be utilised as basis for further research and purposeful policy measures to increase persistence in Science, Engineering and Technology for students with diverse backgrounds.

Widespread evidence for interspecific mating between Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in nature.

PubMed

Bargielowski, I E; Lounibos, L P; Shin, D; Smartt, C T; Carrasquilla, M C; Henry, A; Navarro, J C; Paupy, C; Dennett, J A

2015-12-01

Aedes aegypti and Aedes albopictus, two important vectors of the dengue and chikungunya viruses to humans, often come in contact in their invasive ranges. In these circumstances, a number of factors are thought to influence their population dynamics, including resource competition among the larval stages, prevailing environmental conditions and reproductive interference in the form of satyrization. As the distribution and abundance of Ae. aegypti and Ae. albopictus have profound epidemiological implications, understanding the competitive interactions that influence these patterns in nature is important. While evidence for resource competition and environmental factors had been gathered from the field, the evidence for reproductive interference, though strongly inferred through laboratory trials, remained sparse (one small-scale field trial). In this paper we demonstrate that low rates (1.12-3.73%) of interspecific mating occur in nature among populations of these species that have co-existed sympatrically from 3 to 150yrs. Finally this report contributes a new species-specific primer set for identifying the paternity of sperm extracted from field collected specimens. Copyright © 2015 Elsevier B.V. All rights reserved.

Functional photonic crystal fiber sensing devices

NASA Astrophysics Data System (ADS)

Villatoro, Joel; Finazzi, Vittoria; Pruneri, Valerio

2011-12-01

We report on a functional, highly reproducible and cost effective sensing platform based on photonic crystal fibers (PCFs). The platform consists of a centimeter-length segment of an index-guiding PCF fusion spliced to standard single mode fibers (SMFs). The voids of the PCF are intentionally sealed over an adequate length in the PCF-SMF interfaces. A microscopic collapsed region in the PCF induces a mode field mismatch which combined with the axial symmetry of the structure allow the efficient excitation and recombination or overlapping of azimuthal symmetric modes in the PCF. The transmission or reflection spectrum of the devices exhibits a high-visibility interference pattern or a single, profound and narrow notch. The interference pattern or the notch position shifts when the length of the PCF experiences microelongations or when liquids or coatings are present on the PCF surface. Thus, the platform here proposed can be useful for sensing diverse parameters such as strain, vibration, pressure, humidity, refractive index, gases, etc. Unlike other PCF-based sensing platforms the multiplexing of the devices here proposed is simple for which it is possible to implement PCF-based sensor arrays or networks.

Antiviral Defense Mechanisms in Honey Bees

PubMed Central

Brutscher, Laura M.; Daughenbaugh, Katie F.; Flenniken, Michelle L.

2015-01-01

Honey bees are significant pollinators of agricultural crops and other important plant species. High annual losses of honey bee colonies in North America and in some parts of Europe have profound ecological and economic implications. Colony losses have been attributed to multiple factors including RNA viruses, thus understanding bee antiviral defense mechanisms may result in the development of strategies that mitigate colony losses. Honey bee antiviral defense mechanisms include RNA-interference, pathogen-associated molecular pattern (PAMP) triggered signal transduction cascades, and reactive oxygen species generation. However, the relative importance of these and other pathways is largely uncharacterized. Herein we review the current understanding of honey bee antiviral defense mechanisms and suggest important avenues for future investigation. PMID:26273564

Monkeys have a limited form of short-term memory in audition

PubMed Central

Scott, Brian H.; Mishkin, Mortimer; Yin, Pingbo

2012-01-01

A stimulus trace may be temporarily retained either actively [i.e., in working memory (WM)] or by the weaker mnemonic process we will call passive short-term memory, in which a given stimulus trace is highly susceptible to “overwriting” by a subsequent stimulus. It has been suggested that WM is the more robust process because it exploits long-term memory (i.e., a current stimulus activates a stored representation of that stimulus, which can then be actively maintained). Recent studies have suggested that monkeys may be unable to store acoustic signals in long-term memory, raising the possibility that they may therefore also lack auditory WM. To explore this possibility, we tested rhesus monkeys on a serial delayed match-to-sample (DMS) task using a small set of sounds presented with ∼1-s interstimulus delays. Performance was accurate whenever a match or a nonmatch stimulus followed the sample directly, but it fell precipitously if a single nonmatch stimulus intervened between sample and match. The steep drop in accuracy was found to be due not to passive decay of the sample’s trace, but to retroactive interference from the intervening nonmatch stimulus. This “overwriting” effect was far greater than that observed previously in serial DMS with visual stimuli. The results, which accord with the notion that WM relies on long-term memory, indicate that monkeys perform serial DMS in audition remarkably poorly and that whatever success they had on this task depended largely, if not entirely, on the retention of stimulus traces in the passive form of short-term memory. PMID:22778411

Monkeys have a limited form of short-term memory in audition.

PubMed

Scott, Brian H; Mishkin, Mortimer; Yin, Pingbo

2012-07-24

A stimulus trace may be temporarily retained either actively [i.e., in working memory (WM)] or by the weaker mnemonic process we will call passive short-term memory, in which a given stimulus trace is highly susceptible to "overwriting" by a subsequent stimulus. It has been suggested that WM is the more robust process because it exploits long-term memory (i.e., a current stimulus activates a stored representation of that stimulus, which can then be actively maintained). Recent studies have suggested that monkeys may be unable to store acoustic signals in long-term memory, raising the possibility that they may therefore also lack auditory WM. To explore this possibility, we tested rhesus monkeys on a serial delayed match-to-sample (DMS) task using a small set of sounds presented with ~1-s interstimulus delays. Performance was accurate whenever a match or a nonmatch stimulus followed the sample directly, but it fell precipitously if a single nonmatch stimulus intervened between sample and match. The steep drop in accuracy was found to be due not to passive decay of the sample's trace, but to retroactive interference from the intervening nonmatch stimulus. This "overwriting" effect was far greater than that observed previously in serial DMS with visual stimuli. The results, which accord with the notion that WM relies on long-term memory, indicate that monkeys perform serial DMS in audition remarkably poorly and that whatever success they had on this task depended largely, if not entirely, on the retention of stimulus traces in the passive form of short-term memory.

Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction.

PubMed

Quednow, Boris B; Jessen, Frank; Kuhn, Kai-Uwe; Maier, Wolfgang; Daum, Irene; Wagner, Michael

2006-05-01

Chronic administration of the common club drug 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is associated with long-term depletion of serotonin (5-HT) and loss of 5-HT axons in the brains of rodents and non-human primates, and evidence suggests that recreational MDMA consumption may also affect the human serotonergic system. Moreover, it was consistently shown that abstinent MDMA users have memory deficits. Recently, it was supposed that these deficits are an expression of a temporal or rather hippocampal dysfunction caused by the serotonergic neurotoxicity of MDMA. The aim of this study is to examine the memory deficits of MDMA users neuropsychologically in order to evaluate the role of different brain regions. Nineteen male abstinent MDMA users, 19 male abstinent cannabis users and 19 male drug-naive control subjects were examined with a German version of the Rey Auditory Verbal Learning Test (RAVLT). MDMA users showed widespread and marked verbal memory deficits, compared to drug-naive controls as well as compared to cannabis users, whereas cannabis users did not differ from control subjects in their memory performance. MDMA users revealed impairments in learning, consolidation, recall and recognition. In addition, they also showed a worse recall consistency and strong retroactive interference whereby both measures were previously associated with frontal lobe function. There was a significant correlation between memory performance and the amount of MDMA taken. These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex.

Characterizing Adult Age Differences in the Initiation and Organization of Retrieval: A Further Investigation of Retrieval Dynamics in Dual-List Free Recall

PubMed Central

Wahlheim, Christopher N.; Richmond, Lauren L.; Huff, Mark J.; Dobbins, Ian G.

2016-01-01

In a recent experiment using dual-list free recall of unrelated word lists, C.N. Wahlheim and M. J. Huff (2015) found that relative to younger adults, older adults showed: 1) impaired recollection of temporal context, 2) a broader pattern of retrieval initiation when recalling from two lists, and 3) more intrusions when selectively recalling from one of two lists. These findings showed older adults' impaired ability to use controlled retrieval to avoid proactive and retroactive interference. In the present investigation, three studies examined whether differences in retrieval initiation patterns were unique to aging and whether they were governed by the control mechanisms that underlie individuals' susceptibility to intrusions. In Study 1, we conducted additional analyses of Wahlheim and Huff's data and found that older adults' broader retrieval initiation when recalling two lists was a unique effect of age that was not redundant with intrusions made when recalling from individual lists. In Study 2, we replicated these age differences in a dual-list paradigm with semantically associated lists. In Study 3, we found that older adults' broader retrieval initiation generalized when they were given twice the encoding time compared to Study 2. Analyses of transitions between recalls in Studies 2 and 3 showed that older adults used temporal associations less than younger adults, but both groups made similar use of semantic associations. Overall, these findings demonstrate adult age differences in the controlled retrieval of temporal context in hierarchically structured events. PMID:27831715

Executive dysfunction affects word list recall performance: Evidence from amyotrophic lateral sclerosis and other neurodegenerative diseases.

PubMed

Consonni, Monica; Rossi, Stefania; Cerami, Chiara; Marcone, Alessandra; Iannaccone, Sandro; Francesco Cappa, Stefano; Perani, Daniela

2017-03-01

The Rey Auditory Verbal Learning Test (RAVLT) is widely used in clinical practice to evaluate verbal episodic memory. While there is evidence that RAVLT performance can be influenced by executive dysfunction, the way executive disorders affect the serial position curve (SPC) has not been yet explored. To this aim, we analysed immediate and delayed recall performances of 13 non-demented amyotrophic lateral sclerosis (ALS) patients with a specific mild executive dysfunction (ALSci) and compared their performances to those of 48 healthy controls (HC) and 13 cognitively normal patients with ALS. Moreover, to control for the impact of a severe dysexecutive syndrome and a genuine episodic memory deficit on the SPC, we enrolled 15 patients with a diagnosis of behavioural variant of frontotemporal dementia (bvFTD) and 18 patients with probable Alzheimer's disease (AD). Results documented that, compared to cognitively normal subjects, ALSci patients had a selective mid-list impairment for immediate recall scores. The bvFTD group obtained low performances with a selectively increased forgetting rate for terminal items, whereas the AD group showed a disproportionately large memory loss on the primary and middle part of the SPC for immediate recall scores and were severely impaired in the delayed recall trial. These results suggested that subtle executive dysfunctions might influence the recall of mid-list items, possibly reflecting deficiency in control strategies at retrieval of word lists, whereas severer dysexecutive syndrome might also affect the recall of terminal items possibly due to attention deficit or retroactive interference. © 2015 The British Psychological Society.

Visual stimuli and written production of deaf signers.

PubMed

Jacinto, Laís Alves; Ribeiro, Karen Barros; Soares, Aparecido José Couto; Cárnio, Maria Silvia

2012-01-01

To verify the interference of visual stimuli in written production of deaf signers with no complaints regarding reading and writing. The research group consisted of 12 students with education between the 4th and 5th grade of elementary school, with severe or profound sensorineural hearing loss, users of LIBRAS and with alphabetical writing level. The evaluation was performed with pictures in a logical sequence and an action picture. The analysis used the communicative competence criteria. There were no differences in the writing production of the subjects for both stimuli. In all texts there was no title and punctuation, verbs were in the infinitive mode, there was lack of cohesive links and inclusion of created words. The different visual stimuli did not affect the production of texts.

MAP Fault Localization Based on Wide Area Synchronous Phasor Measurement Information

NASA Astrophysics Data System (ADS)

Zhang, Yagang; Wang, Zengping

2015-02-01

In the research of complicated electrical engineering, the emergence of phasor measurement units (PMU) is a landmark event. The establishment and application of wide area measurement system (WAMS) in power system has made widespread and profound influence on the safe and stable operation of complicated power system. In this paper, taking full advantage of wide area synchronous phasor measurement information provided by PMUs, we have carried out precise fault localization based on the principles of maximum posteriori probability (MAP). Large numbers of simulation experiments have confirmed that the results of MAP fault localization are accurate and reliable. Even if there are interferences from white Gaussian stochastic noise, the results from MAP classification are also identical to the actual real situation.

The State Secrets Privilege and Other Limits on Litigation Involving Classified Information

DTIC Science & Technology

2009-05-28

Privilege And Separation Of Powers , 75 FORDHAM L. REV. 1931, 1935 (Mar. 2007). 2 Editorial, Securing Lawsuits, WASH. POST, May 11, 2009, at A16...the Supreme Court invalidated a legislative enactment that required federal courts to reopen final decisions as a violation of the separation of powers principle...95 It might be argued that the retroactivity provision in H.R. 984 also reopens final judgments in violation of the separation of powers principle

In Search of Command and Staff Doctrine.

DTIC Science & Technology

1987-05-01

authority, resposibility , and accountability." 21. In both Article 90 and Article 92 of the Unior Code, the orders of ccmders are given a special...the dates the orders are published, i.e., retroactive and prospective appointments. Hovever, there is presently no procedure for self -terminating...with your- self !" S 137 U. S. Grant, Personal Memoirs 343 (Da Capo Press ed. 1982). See also Op. JAGAF 1978/62, June 6, 1978: "Giving Air Force officers

’Don’t Ask, Don’t Tell’ Policy: Is It Time to Talk?

DTIC Science & Technology

2009-03-26

personnel, it would merely be another form of discrimination . Gays must be extended the same full rights and privileges governing relationships, housing...sexuality. As an editor for The New Republic, Andrew Sullivan points out, “gay people are not uniformly discriminated against; openly gay people are.”94...previously denied, retroactive promotions, and financial settlements for persons claiming past discrimination .”99 President Obama indicated his intent to

Investigation into the Impacts of Migration to Emergent NSA Suite B Encryption Standards

DTIC Science & Technology

2009-06-01

detailed statistical information on the difference between the 1024-bit keys and 2048-bit keys. D. ENCRYPTION TAXONOMY The modern field of...because they had already published their ideas globally and most 6 countries bar retroactive patenting of open source concepts. In September 2000, the...order of p operations in a finite field of numbers as large as p itself. If exhaustive search were the best attack on these systems, then bit

Depth- and range-dependent variation in the performance of aquatic telemetry systems: understanding and predicting the susceptibility of acoustic tag-receiver pairs to close proximity detection interference.

PubMed

Scherrer, Stephen R; Rideout, Brendan P; Giorli, Giacomo; Nosal, Eva-Marie; Weng, Kevin C

2018-01-01

Passive acoustic telemetry using coded transmitter tags and stationary receivers is a popular method for tracking movements of aquatic animals. Understanding the performance of these systems is important in array design and in analysis. Close proximity detection interference (CPDI) is a condition where receivers fail to reliably detect tag transmissions. CPDI generally occurs when the tag and receiver are near one another in acoustically reverberant settings. Here we confirm transmission multipaths reflected off the environment arriving at a receiver with sufficient delay relative to the direct signal cause CPDI. We propose a ray-propagation based model to estimate the arrival of energy via multipaths to predict CPDI occurrence, and we show how deeper deployments are particularly susceptible. A series of experiments were designed to develop and validate our model. Deep (300 m) and shallow (25 m) ranging experiments were conducted using Vemco V13 acoustic tags and VR2-W receivers. Probabilistic modeling of hourly detections was used to estimate the average distance a tag could be detected. A mechanistic model for predicting the arrival time of multipaths was developed using parameters from these experiments to calculate the direct and multipath path lengths. This model was retroactively applied to the previous ranging experiments to validate CPDI observations. Two additional experiments were designed to validate predictions of CPDI with respect to combinations of deployment depth and distance. Playback of recorded tags in a tank environment was used to confirm multipaths arriving after the receiver's blanking interval cause CPDI effects. Analysis of empirical data estimated the average maximum detection radius (AMDR), the farthest distance at which 95% of tag transmissions went undetected by receivers, was between 840 and 846 m for the deep ranging experiment across all factor permutations. From these results, CPDI was estimated within a 276.5 m radius of the receiver. These empirical estimations were consistent with mechanistic model predictions. CPDI affected detection at distances closer than 259-326 m from receivers. AMDR determined from the shallow ranging experiment was between 278 and 290 m with CPDI neither predicted nor observed. Results of validation experiments were consistent with mechanistic model predictions. Finally, we were able to predict detection/nondetection with 95.7% accuracy using the mechanistic model's criterion when simulating transmissions with and without multipaths. Close proximity detection interference results from combinations of depth and distance that produce reflected signals arriving after a receiver's blanking interval has ended. Deployment scenarios resulting in CPDI can be predicted with the proposed mechanistic model. For deeper deployments, sea-surface reflections can produce CPDI conditions, resulting in transmission rejection, regardless of the reflective properties of the seafloor.

Factors affecting the retirement of commercial transport jet aircraft

NASA Technical Reports Server (NTRS)

Spencer, F. A.

1979-01-01

The historical background of the technology and economics of aircraft replacement and retirement in the prejet era is reviewed in order to determine whether useful insights can be obtained applicable to the jet era. Significant differences between the two periods are noted. New factors are identified and examined. Topics discussed include concern over current policies regarding deregulation, regulatory reform, and retroactive noise regulations; financing and compliance legislation; aging; economic environment and inflation; technological progress; fuel efficiency and cost; and a financial perspective of replacement decisions.

An Analysis of the Mineral Industries of the Republics of China, the Philippines, and Korea, the Kingdom of Thailand, and New Zealand. Volume II. Chapters 5-7.

DTIC Science & Technology

1984-12-01

export and business taxes ; and (’) allowance to deduct from the corporate taxable income the e.uivalent c-f 5 percent of an increase in income derived...the Thai Government added retroactive tax measures to many corporations, increasing accounting costs and causing many hard feelings. Executives of...within a free enterprise system with government regulation exercised mainly through the banking system. Social and economic trends include increasing

NGPA disputes plague operators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stremel, K.

1984-03-01

Conflicting interpretations of the Natural Gas Policy Act of 1978 have natural gas producers in a costly financial dilemma. A recent circuit court of appeals decision allows for a different method for the calculation of Btu values for gas. This dry method for Btu calculation gives a lower cost for natural gas and therefore cost pipelines an estimated one billion dollars in over payments. The court has declared that their decision is retroactive and that producers must pay the debt. Discussions from both sides are presented.

Cerebral basis of posttraumatic stress disorder following the Chernobyl disaster.

PubMed

Loganovsky, Konstantin N; Zdanevich, Nataliya A

2013-04-01

Whether posttraumatic stress disorder (PTSD) following radiation emergency has psychopathological, neurocognitive, and neurophysiological peculiarities is at issue. The goal was to explore the features and cerebral basis of "radiation" PTSD in the survivors of the Chernobyl accident. Subjects and Methods The cross-sectional study included 241 people, 219 of whom have been diagnosed with PTSD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) criteria, among them 115 clean-up workers of the Chernobyl accident (34 with acute radiation sickness), 76 evacuees from the Chernobyl exclusion zone, 28 veterans of the war in Afghanistan, and 22 healthy unexposed individuals. Psychometric examinations, neurocognitive assessments, computerized electroencephalography, and cerebral vascular Doppler were used. "Radiation" PTSD includes "flashforward" phenomena and anticipating stress (projection of fear and danger to the future); somatoform disorders (depression, trait and state anxiety); and neurocognitive deficit (impaired memory and attention, auditory-verbal memory and learning, proactive and retroactive interference, cerebellar and stem symptoms, intellectual changes). The intima-media component, thickness of common carotid arteries, and common and left internal carotid arteries stenosis rates are increased in the liquidators. Changes of bioelectrical brain activity as a decrease of beta- and theta-power, together with an increase of alpha-power, were found in the Chernobyl accident survivors with PTSD. PTSD following radiation emergency is characterized by comorbidity of psychopathology, neurocognitive deficit, and cerebrovascular pathology with increased risk of cerebral atherosclerosis and stroke. The cerebral basis of this PTSD is proposed to be an abnormal communication between the pyramidal cells of the neocortex and the hippocampus, and deep brain structures. It is recommended that a system of emergency and long-term psychological and psychiatric care be organized for the survivors in Fukushima Daichi, Japan.

Using Neuropsychological Process Scores to Identify Subtle Cognitive Decline and Predict Progression to Mild Cognitive Impairment.

PubMed

Thomas, Kelsey R; Edmonds, Emily C; Eppig, Joel; Salmon, David P; Bondi, Mark W

2018-05-26

We previously operationally-defined subtle cognitive decline (SCD) in preclinical Alzheimer's disease (AD) using total scores on neuropsychological (NP) tests. NP process scores (i.e., provide information about how a total NP score was achieved) may be a useful tool for identifying early cognitive inefficiencies prior to objective impairment seen in mild cognitive impairment (MCI) and dementia. We aimed to integrate process scores into the SCD definition to identify stages of SCD and improve early detection of those at risk for decline. Cognitively "normal" participants from the Alzheimer's Disease Neuroimaging Initiative were classified as "early" SCD (E-SCD; >1 SD below mean on 2 process scores or on 1 process score plus 1 NP total score), "late" SCD (L-SCD; existing SCD criteria of >1 SD below norm-adjusted mean on 2 NP total scores in different domains), or "no SCD" (NC). Process scores considered in the SCD criteria were word-list intrusion errors, retroactive interference, and learning slope. Cerebrospinal fluid AD biomarkers were used to examine pathologic burden across groups. E-SCD and L-SCD progressed to MCI 2.5-3.4 times faster than the NC group. Survival curves for E-SCD and L-SCD converged at 7-8 years after baseline. The combined (E-SCD+L-SCD) group had improved sensitivity to detect progression to MCI relative to L-SCD only. AD biomarker positivity increased across NC, SCD, and MCI groups. Process scores can be integrated into the SCD criteria to allow for increased sensitivity and earlier identification of cognitively normal older adults at risk for decline prior to frank impairment on NP total scores.

Mere odor exposure learning in the rat neonate immediately after birth and one day later

PubMed Central

Miller, Stacie S.; Spear, Norman E.

2011-01-01

Rat pups are more resistant to retroactive associative interference 3 hrs after birth than 24 hours later (Cheslock, Sanders, & Spear, 2004). The present experiments tested the effect of age, retention interval and dam presence during the retention interval on odor-induced motor activity subsequent to mere odor exposure. Rats were exposed to an hour of odor immediately after birth or approximately one day later and tested after a given retention interval (3 hrs or 27 hrs [Exp 1]; 0, 30, 75, or 180 min [Exp. 2]). They spent the retention interval either in the presence or absence of a foster dam (Exp. 1 and 3). After the retention interval, pups were tested in a four-minute activity test including a two-minute baseline period and two minutes of odor exposure. Overall activity was scored during tape-playback. Odor-exposed pups were more active than non-exposed pups during reexposure to the odor during testing, but this was true only for P0 pups. In contrast, P1 pups without prior odor exposure were active during testing and behaviorally quieted in the presence of the odor they were previously exposed to. Though one day apart, newborn rats just hours old lack many of the experiences that a one day old has had including nursing, huddling, and being groomed. These experiences are associated with, among other stimuli, a barrage of olfactory cues (e.g., colostrum, saliva, dander, feces, and urine). P0 and P1 pups also differ in their proximity from the birthing experience and associated neurochemical changes. The age-related pattern of responding to odors based on previous odor exposure was discussed in relation to these and other possibilities. PMID:20411590

Mere odor exposure learning in the rat neonate immediately after birth and 1 day later.

PubMed

Miller, Stacie S; Spear, Norman E

2010-05-01

Rat pups are more resistant to retroactive associative interference 3 hr after birth than 24 hr later [Cheslock et al. [2004] Developmental Science, 7, 581-598]. The present experiments tested the effect of age, retention interval and dam presence during the retention interval on odor-induced motor activity subsequent to mere odor exposure. Rats were exposed to an hour of odor immediately after birth or approximately 1 day later and tested after a given retention interval (3 or 27 hr [Exp 1]; 0, 30, 75, or 180 min [Exp. 2]). They spent the retention interval either in the presence or absence of a foster dam (Exp. 1 and 3). After the retention interval, pups were tested in a 4-min activity test including a 2-min baseline period and 2 min of odor exposure. Overall activity was scored during tape-playback. Odor-exposed pups were more active than nonexposed pups during reexposure to the odor during testing, but this was true only for P0 pups. In contrast, P1 pups without prior odor exposure were active during testing and behaviorally quieted in the presence of the odor they were previously exposed to. Though 1 day apart, newborn rats just hours old lack many of the experiences that a 1-day-old has had including nursing, huddling, and being groomed. These experiences are associated with, among other stimuli, a barrage of olfactory cues (e.g., colostrum, saliva, dander, feces, and urine). P0 and P1 pups also differ in their proximity from the birthing experience and associated neurochemical changes. The age-related pattern of responding to odors based on previous odor exposure was discussed in relation to these and other possibilities.

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial.

PubMed

Morgan, Annette; Stevens, John

2010-07-01

The objective of this study was to investigate the effectiveness of Bacopa monnieri Linn. for improvement of memory performance in healthy older persons. This was a randomized, double-blind, placebo-controlled trial. The trial took place in Lismore, NSW, Australia between February and July 2005. Ninety-eight (98) healthy participants over 55 years of age were recruited from the general population. Participants were randomized to receive an extract of Bacopa monnieri called BacoMind(TM) (Natural Remedies Pvt. Ltd.), 300 mg/day, or an identical placebo. Following screening, neuropsychologic and subjective memory assessments were performed at baseline and at 12 weeks. Audioverbal and visual memory performance were measured by the Rey Auditory Verbal Learning Test (AVLT), the Rey-Osterrieth Complex Figure Test (CFT), and the Reitan Trail Making Test (TMT). Subjective memory performance was measured by the Memory Complaint Questionnaire (MAC-Q). One hundred and thirty-six (136) subjects volunteered; 103 met entry criteria, 98 commenced, and 81 completed the trial. Bacopa significantly improved verbal learning, memory acquisition, and delayed recall as measured by the AVLT: trial a4 (p = 0.000), trial a5 (p = 0.016); trial a6 (p = 0.000); trial a7 (delayed recall) (p = 0.001); total learning (p = 0.011); and retroactive interference (p = 0.048). CFT, MAC-Q, and TMT scores improved but group differences were not significant. Bacopa versus placebo caused gastrointestinal tract (GIT) side-effects. Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.

Synergy of understanding dermatologic disease and epidermal biology.

PubMed

Stanley, John R

2012-02-01

Dermatologic disease, although seldom life threatening, can be extremely disfiguring and interfere with the quality of life. In addition, as opposed to other organs, just the aging of skin and its adnexal structure the hair follicle can result in cosmetic concerns that affect most of us. The articles in this dermatology Review Series demonstrate recent progress in understanding the cell biology and molecular pathophysiology of the epidermis and hair follicles, which harbor keratinocyte and melanocyte stem cells. They reveal a dynamic relationship between research and clinical care: knowledge of dermatologic disease has facilitated the understanding of the biology of the epidermis and, in turn, progress in basic science has informed our understanding of disease. This type of synergy is a profound strength of clinical research of the type that the JCI is dedicated to publishing.

Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability.

PubMed

Rimmer, James H; Herman, Cassandra; Wingo, Brooks; Fontaine, Kevin; Mehta, Tapan

2018-03-14

Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues. Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e.g., cardiorespiratory endurance, strength, balance), and environmental and sociocultural factors. In Phase 2, eligible participants with neurologic disability from Phase 1 (in our example, individuals with multiple sclerosis) are screened and randomized to a clinical exercise efficacy trial. In Phase 3, study participants are enrolled in a home-based teleexercise trial to test the feasibility and replicability of delivering the clinical exercise study in the home. This unique three-in-one Russian doll framework serves as a foundation for informing and guiding researchers and clinicians in treating certain health and functional deficits in people with neurologic disability using exercise as a primary treatment modality in both the clinical and home settings. It offers a unique perspective for understanding the critical issues of functioning, health maintenance and quality of life for people with neurologic disability across a longitudinal framework. Study 2 ClinicalTrials.gov identifier NCT02533882 (retroactively registered 03/06/2015). Study 3 ClinicalTrials.gov identifier NCT03108950 (retroactively registered 04/05/2017).

Ultrahigh-sensitive multimode interference-based fiber optic liquid-level sensor realized using illuminating zero-order Bessel-Gauss beam

NASA Astrophysics Data System (ADS)

Saha, Ardhendu; Datta, Arijit; Kaman, Surjit

2018-03-01

A proposal toward the enhancement in the sensitivity of a multimode interference-based fiber optic liquid-level sensor is explored analytically using a zero-order Bessel-Gauss (BG) beam as the input source. The sensor head consists of a suitable length of no-core fiber (NCF) sandwiched between two specialty high-order mode fibers. The coupling efficiency of various order modes inside the sensor structure is assessed using guided-mode propagation analysis and the performance of the proposed sensor has been benchmarked against the conventional sensor using a Gaussian beam. Furthermore, the study has been corroborated using a finite-difference beam propagation method in Lumerical's Mode Solutions software to investigate the propagation of the zero-order BG beam inside the sensor structure. Based on the simulation outcomes, the proposed scheme yields a maximum absolute sensitivity of up to 3.551 dB / mm and a sensing resolution of 2.816 × 10 - 3 mm through the choice of an appropriate length of NCF at an operating wavelength of 1.55 μm. Owing to this superior sensing performance, the reported sensing technology expedites an avenue to devise a high-performance fiber optic-level sensor that finds profound implication in different physical, biological, and chemical sensing purposes.

Selective disruption of the AKAP signaling complexes.

PubMed

Kennedy, Eileen J; Scott, John D

2015-01-01

Synthesis of the second messenger cAMP activates a variety of signaling pathways critical for all facets of intracellular regulation. Protein kinase A (PKA) is the major cAMP-responsive effector. Where and when this enzyme is activated has profound implications on the cellular role of PKA. A-Kinase Anchoring Proteins (AKAPs) play a critical role in this process by orchestrating spatial and temporal aspects of PKA action. A popular means of evaluating the impact of these anchored signaling events is to biochemically interfere with the PKA-AKAP interface. Hence, peptide disruptors of PKA anchoring are valuable tools in the investigation of local PKA action. This article outlines the development of PKA isoform-selective disruptor peptides, documents the optimization of cell-soluble peptide derivatives, and introduces alternative cell-based approaches that interrogate other aspects of the PKA-AKAP interface.

Retroactive Event Determination and Its Relativistic Roots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Sky E.

Quantum theory limits what we are allowed to say about the 'true' state of a quantum system if that system is unobserved. But special relativity relies fundamentally on a universal assumption about what a light particle is doing at ALL times, regardless of being observed (namely, traveling at speed c relative to any inertial observer). This constitutes a fundamental conceptual gap between the theories. In resolving this impasse we show that the state of a light particle (and hence space and time) is not objective or continuous. Time dilation and length contraction become infinite for a photon, so light hasmore » no 'experience' of event separation in space or time ({Delta}t' = 0, {Delta}x' = 0). The principle of simultaneity is applied between an inertial observer and a light particle, such that the relative speed of the two systems is c, and gamma = infinite/undefined. Although light experiences no separation between events, the Lorentz transform {Delta}t' = {gamma} ({Delta}t-{Delta}Lv/c{sup 2}) implies that the inertial observer experiences a separation between those same events of exactly {Delta}t = {Delta}L/c, a light-like separation. In other words, although light does not 'register' time or space itself, light will always be measured by an inertial observer at a position and time exactly as if it had travelled at speed c continuously through the intervening medium. This fits nicely within the limitations set by quantum mechanics. This result is connected with previous work on retroactive event determination, suggesting the ubiquitous existence of ''synchronicity''.« less

Research on vacuum utraviolet calibration technology

NASA Astrophysics Data System (ADS)

Wang, Jiapeng; Gao, Shumin; Sun, Hongsheng; Chen, Yinghang; Wei, Jianqiang

2014-11-01

Importance of extreme ultraviolet (EUV) and far ultraviolet (FUV) calibration is growing fast as vacuum ultraviolet payloads are wildly used in national space plan. A calibration device is established especially for the requirement of EUV and FUV metrology and measurement. Spectral radiation and detector relative spectral response at EUV and FUV wavelengths can be calibrated with accuracy of 26% and 20%, respectively. The setup of the device, theoretical model and value retroactive method are introduced and measurement of detector relative spectral response from 30 nm to 200 nm is presented in this paper. The calibration device plays an important role in national space research.

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

PubMed

Pérez-Moreno, Guiomar; Sealey-Cardona, Marco; Rodrigues-Poveda, Carlos; Gelb, Michael H; Ruiz-Pérez, Luis Miguel; Castillo-Acosta, Víctor; Urbina, Julio A; González-Pacanowska, Dolores

2012-10-01

Sterol biosynthesis inhibitors are promising entities for the treatment of trypanosomal diseases. Insect forms of Trypanosoma brucei, the causative agent of sleeping sickness, synthesize ergosterol and other 24-alkylated sterols, yet also incorporate cholesterol from the medium. While sterol function has been investigated by pharmacological manipulation of sterol biosynthesis, molecular mechanisms by which endogenous sterols influence cellular processes remain largely unknown in trypanosomes. Here we analyse by RNA interference, the effects of a perturbation of three specific steps of endogenous sterol biosynthesis in order to dissect the role of specific intermediates in proliferation, mitochondrial function and cellular morphology in procyclic cells. A decrease in the levels of squalene synthase and squalene epoxidase resulted in a depletion of cellular sterol intermediates and end products, impaired cell growth and led to aberrant morphologies, DNA fragmentation and a profound modification of mitochondrial structure and function. In contrast, cells deficient in sterol methyl transferase, the enzyme involved in 24-alkylation, exhibited a normal growth phenotype in spite of a complete abolition of the synthesis and content of 24-alkyl sterols. Thus, the data provided indicates that while the depletion of squalene and post-squalene endogenous sterol metabolites results in profound cellular defects, bulk 24-alkyl sterols are not strictly required to support growth in insect forms of T. brucei in vitro. Copyright © 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Lethal effects of habitat degradation on fishes through changing competitive advantage.

PubMed

McCormick, Mark I

2012-10-07

Coral bleaching has caused catastrophic changes to coral reef ecosystems around the world with profound ecological, social and economic repercussions. While its occurrence is predicted to increase in the future, we have little understanding of mechanisms that underlie changes in the fish community associated with coral degradation. The present study uses a field-based experiment to examine how the intensity of interference competition between juveniles of two species of damselfish changes as healthy corals degrade through thermal bleaching. The mortality of a damselfish that is a live coral specialist (Pomacentrus moluccensis) increased on bleached and dead coral in the presence of the habitat generalist (Pomacentrus amboinensis). Increased mortality of the specialist was indirectly owing to enhanced aggression by the generalist forcing the specialist higher up and further away from shelter on bleached and dead coral. Evidence from this study stresses the importance of changing interspecific interactions to community dynamics as habitats change.

Earnings Management before Rights Issues and the Subsequent Cash Transfer in Chinese Firms

NASA Astrophysics Data System (ADS)

Tsai, Bi-Huei

2009-08-01

Unlike private enterprises in developed markets, political influence is profound upon Chinese state-dominated firms. Under this consideration, this paper demonstrates how political impact interferes in Chinese managers' decisions. State-assigned managers were found to deliberately transfer cash raised via rights issues from the public shareholders to the state by cash dividends in order to please Chinese politicians. Especially, to meet the regulatory requirement of rights issues, managers from firms which distributed more cash dividends in the same year of rights issues were more likely to inflate earnings before rights issues. The earnings inflation which managers use to boost firm's incomes is defined as "earnings management." Furthermore, the empirical results also exhibit that firm's close relationship with the state enables managers to obtain approvals of rights issues easily, which reduces the firm's earnings management tendency. The manager's incentives of earnings management is closely attributed to the political intervention.

A brief history of phosphorus: from the philosopher's stone to nutrient recovery and reuse.

PubMed

Ashley, K; Cordell, D; Mavinic, D

2011-08-01

The element phosphorus has no substitute in sustaining all life and food production on our planet. Yet today's phosphorus use patterns have resulted in both a global environmental epidemic of eutrophication and led to a situation where the future availability of the world's main sources of phosphorus is uncertain. This paper examines the important history of human interference with the phosphorus cycle from initial discovery to present, highlighting key interrelated events and consequences of the Industrial Revolution, Sanitation Revolution and Green Revolution. Whilst these events led to profound advances in technology, public health and food production, they have fundamentally broken the global phosphorus cycle. It is clear a 'Fourth Revolution' is required to resolve this dilemma and ensure humanity can continue to feed itself into the future while protecting environmental and human health. Copyright © 2011 Elsevier Ltd. All rights reserved.

Function of alternative splicing

PubMed Central

Kelemen, Olga; Convertini, Paolo; Zhang, Zhaiyi; Wen, Yuan; Shen, Manli; Falaleeva, Marina; Stamm, Stefan

2017-01-01

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes. Alternative splicing regulates the localization of proteins, their enzymatic properties and their interaction with ligands. In most cases, changes caused by individual splicing isoforms are small. However, cells typically coordinate numerous changes in ‘splicing programs’, which can have strong effects on cell proliferation, cell survival and properties of the nervous system. Due to its widespread usage and molecular versatility, alternative splicing emerges as a central element in gene regulation that interferes with almost every biological function analyzed. PMID:22909801

The Plant Polyester Cutin: Biosynthesis, Structure, and Biological Roles.

PubMed

Fich, Eric A; Segerson, Nicholas A; Rose, Jocelyn K C

2016-04-29

Cutin, a polyester composed mostly of oxygenated fatty acids, serves as the framework of the plant cuticle. The same types of cutin monomers occur across most plant lineages, although some evolutionary trends are evident. Additionally, cutins from some species have monomer profiles that are characteristic of the related polymer suberin. Compositional differences likely have profound structural consequences, but little is known about cutin's molecular organization and architectural heterogeneity. Its biological importance is suggested by the wide variety of associated mutants and gene-silencing lines that show a disruption of cuticular integrity, giving rise to numerous physiological and developmental abnormalities. Mapping and characterization of these mutants, along with suppression of gene paralogs through RNA interference, have revealed much of the biosynthetic pathway and several regulatory factors; however, the mechanisms of cutin polymerization and its interactions with other cuticle and cell wall components are only now beginning to be resolved.

The sleep needs of adolescents.

PubMed

Kelman, B B

1999-08-01

The amount of sleep affects the way adolescents perform, feel, think, learn, and remember. Significant physiological and social changes have profound effects on adolescents' sleeping patterns. Lack of sleep increases the possibility of increased daytime sleepiness, which may result in a tragic automobile or work accident. Other consequences of sleep deprivation include poor school performance, heightened risk of drug and alcohol use, increased irritability, and aggressive behavior, all of which can interfere with relationships with classmates, parents, and teachers. The purpose of this paper is to explore the literature concerning what is known about why adolescents need more sleep and why adolescents do not obtain enough sleep. Nursing interventions targeting adolescents, parents, teachers, schools, and employers are included. If adolescents understand and learn to improve their sleep patterns while they are young, they may have improved sleep habits in adulthood. Teaching adolescents about the importance of sleep is an important task for school nurses.

Divergent short- and long-term effects of acute stress in object recognition memory are mediated by endogenous opioid system activation.

PubMed

Nava-Mesa, Mauricio O; Lamprea, Marisol R; Múnera, Alejandro

2013-11-01

Acute stress induces short-term object recognition memory impairment and elicits endogenous opioid system activation. The aim of this study was thus to evaluate whether opiate system activation mediates the acute stress-induced object recognition memory changes. Adult male Wistar rats were trained in an object recognition task designed to test both short- and long-term memory. Subjects were randomly assigned to receive an intraperitoneal injection of saline, 1 mg/kg naltrexone or 3 mg/kg naltrexone, four and a half hours before the sample trial. Five minutes after the injection, half the subjects were submitted to movement restraint during four hours while the other half remained in their home cages. Non-stressed subjects receiving saline (control) performed adequately during the short-term memory test, while stressed subjects receiving saline displayed impaired performance. Naltrexone prevented such deleterious effect, in spite of the fact that it had no intrinsic effect on short-term object recognition memory. Stressed subjects receiving saline and non-stressed subjects receiving naltrexone performed adequately during the long-term memory test; however, control subjects as well as stressed subjects receiving a high dose of naltrexone performed poorly. Control subjects' dissociated performance during both memory tests suggests that the short-term memory test induced a retroactive interference effect mediated through light opioid system activation; such effect was prevented either by low dose naltrexone administration or by strongly activating the opioid system through acute stress. Both short-term memory retrieval impairment and long-term memory improvement observed in stressed subjects may have been mediated through strong opioid system activation, since they were prevented by high dose naltrexone administration. Therefore, the activation of the opioid system plays a dual modulating role in object recognition memory. Copyright © 2013 Elsevier Inc. All rights reserved.

Influence of implantable hearing aids and neuroprosthesison music perception.

PubMed

Rahne, Torsten; Böhme, Lars; Götze, Gerrit

2012-01-01

The identification and discrimination of timbre are essential features of music perception. One dominating parameter within the multidimensional timbre space is the spectral shape of complex sounds. As hearing loss interferes with the perception and enjoyment of music, we approach the individual timbre discrimination skills in individuals with severe to profound hearing loss using a cochlear implant (CI) and normal hearing individuals using a bone-anchored hearing aid (Baha). With a recent developed behavioral test relying on synthetically sounds forming a spectral continuum, the timbre difference was changed adaptively to measure the individual just noticeable difference (JND) in a forced-choice paradigm. To explore the differences in timbre perception abilities caused by the hearing mode, the sound stimuli were varied in their fundamental frequency, thus generating different spectra which are not completely covered by a CI or Baha system. The resulting JNDs demonstrate differences in timbre perception between normal hearing individuals, Baha users, and CI users. Beside the physiological reasons, also technical limitations appear as the main contributing factors.

Dehumanization in organizational settings: some scientific and ethical considerations

PubMed Central

Christoff, Kalina

2014-01-01

Dehumanizing attitudes and behaviors frequently occur in organizational settings and are often viewed as an acceptable, and even necessary, strategy for pursuing personal and organizational goals. Here I examine a number of commonly held beliefs about dehumanization and argue that there is relatively little support for them in light of the evidence emerging from social psychological and neuroscientific research. Contrary to the commonly held belief that everyday forms of dehumanization are innocent and inconsequential, the evidence shows profoundly negative consequences for both victims and perpetrators. As well, the belief that suppressing empathy automatically leads to improved problem solving is not supported by the evidence. The more general belief that empathy interferes with problem solving receives partial support, but only in the case of mechanistic problem solving. Overall, I question the usefulness of dehumanization in organizational settings and argue that it can be replaced by superior strategies that are ethically more acceptable and do not entail the severely negative consequences associated with dehumanization. PMID:25309401

A plea for a broader concept of Nachträglichkeit.

PubMed

Faimberg, Haydée

2007-10-01

The broader conceptualization of Nachträglichkeit proposed by the author can play an active part in the process of assigning new meaning retroactively (usually through interpretation)--and even giving a meaning, for the first time (usually through construction)--to what the analysand says and cannot say. It gives us a conceptual frame of unconscious psychic temporality with which to explore how psychoanalysis produces psychic change. Winnicott's "Fear of Breakdown" (1974) is paradigmatic of this broader conceptualization of Nachträglichkeit (see Faimberg 1998). A clinical example is presented (Kardiner 1977) to illustrate why the author believes that her proposal remains true to Freud's (1937) conception of psychic temporality and construction.

Caution! All data are not created equal: The hazards of using National Weather Service data for calculating accumulated degree days.

PubMed

Dabbs, Gretchen R

2010-10-10

An increasing number of anthropological decomposition studies are utilizing accumulated degree days (ADD) to quantify and estimate the post-mortem interval (PMI) at given decompositional stages, or the number of ADD required for certain events, such as tooth exfoliation, to occur. This study addresses the utility of retroactively applying temperature data from the closest National Weather Service (NWS) station to these calculations as prescribed in the past. Hourly temperature readings were collected for 154 days at a research site in Farmington, AR between June 30 and December 25, 2008. These were converted to average daily temperatures by calculating the mean of the 24 hourly values, following the NWS reporting procedure. These data were compared to comparable data from the Owl Creek and Drake Field NWS stations, the two closest to the research site, located 5.7 and 9.9km away, respectively. Paired samples t-tests between the research site and each of the NWS stations show significant differences between the average daily temperature data collected at the research station, and both Owl Creek (2.0°C, p<0.001) and Drake Field (0.6°C, p<0.001). When applied to a simulated recovery effort, the further NWS station also proved to represent the better model for the recovery site. Using a published equation for estimating post-mortem interval using ADD and total body decomposition scores (Megyesi et al., 2005 [1]), the Drake Field data produced estimates of PMI more closely mirroring those of the research site than did Owl Creek. This demonstrates that instead of automatically choosing the nearest NWS station, care must be taken when choosing an NWS station for retroactively gathering temperature data for application of PMI estimation techniques using accumulated degree days to ensure the station adequately reflects temperature conditions at the recovery site. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory.

PubMed

Scholz-Kornehl, Sabrina; Schwärzel, Martin

2016-07-27

Dopamine is central to reinforcement processing and exerts this function in species ranging from humans to fruit flies. It can do so via two different types of receptors (i.e., D1 or D2) that mediate either augmentation or abatement of cellular cAMP levels. Whereas D1 receptors are known to contribute to Drosophila aversive odor learning per se, we here show that D2 receptors are specific for support of a consolidated form of odor memory known as anesthesia-resistant memory. By means of genetic mosaicism, we localize this function to Kenyon cells, the mushroom body intrinsic neurons, as well as GABAergic APL neurons and local interneurons of the antennal lobes, suggesting that consolidated anesthesia-resistant memory requires widespread dopaminergic modulation within the olfactory circuit. Additionally, dopaminergic neurons themselves require D2R, suggesting a critical role in dopamine release via its recognized autoreceptor function. Considering the dual role of dopamine in balancing memory acquisition (proactive function of dopamine) and its "forgetting" (retroactive function of dopamine), our analysis suggests D2R as central player of either process. Dopamine provides different information; while it mediates reinforcement during the learning act (proactive function), it balances memory performance between two antithetic processes thereafter (retroactive function) (i.e., forgetting and augmentation). Such bidirectional design can also be found at level of dopamine receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels. Here, we report that consolidated anesthesia-resistant memory (ARM), but not other concomitant memory phases, are sensitive to bidirectional dopaminergic signals. By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM. Copyright © 2016 the authors 0270-6474/16/367936-10$15.00/0.

Analysis of dependent scattering mechanism in hard-sphere Yukawa random media

NASA Astrophysics Data System (ADS)

Wang, B. X.; Zhao, C. Y.

2018-06-01

The structural correlations in the microscopic structures of random media can induce the dependent scattering mechanism and thus influence the optical scattering properties. Based on our recent theory on the dependent scattering mechanism in random media composed of discrete dipolar scatterers [B. X. Wang and C. Y. Zhao, Phys. Rev. A 97, 023836 (2018)], in this paper, we study the hard-sphere Yukawa random media, in order to further elucidate the role of structural correlations in the dependent scattering mechanism and hence optical scattering properties. Here, we consider charged colloidal suspensions, whose effective pair interaction between colloids is described by a screened Coulomb (Yukawa) potential. By means of adding salt ions, the pair interaction between the charged particles can be flexibly tailored and therefore the structural correlations are modified. It is shown that this strategy can affect the optical properties significantly. For colloidal TiO2 suspensions, the modification of electric and magnetic dipole excitations induced by the structural correlations can substantially influence the optical scattering properties, in addition to the far-field interference effect described by the structure factor. However, this modification is only slightly altered by different salt concentrations and is mainly because of the packing-density-dependent screening effect. On the other hand, for low refractive index colloidal polystyrene suspensions, the dependent scattering mechanism mainly involves the far-field interference effect, and the effective exciting field amplitude for the electric dipole almost remains unchanged under different structural correlations. The present study has profound implications for understanding the role of structural correlations in the dependent scattering mechanism.

Greenhouse Development Rights. An approach to the global climate regime that takes climate protection seriously while also preserving the right to human development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Athanasiou, T.; Kartha, S.; Baer, P.

2006-11-15

This brief paper introduces a new approach to the global climate regime, one designed to recognize the urgency of the climate crisis, while at the same time embracing the fundamental right to human development. This 'Greenhouse Development Rights' approach is not primarily defended on ethical grounds. It's core justification, rather, is a realistic one - our claim is that this approach, or something like it, is needed if we're to break the global impasse over developmental equity in a climate constrained world. We put forward this new approach not because we believe that it will be readily adopted as themore » foundation of the post-2012 regime. Rather, we intend it as a standard of comparison, a reference framework that marks out the steps that must be part of an effective climate regime, while refusing to prejudge which of them will or will not ultimately be deemed politically acceptable. Against this reference framework, given regime proposals can be measured to determine how realistic they are, from the standpoint of genuinely addressing the North/South impasse and having a chance of preventing a climate catastrophe. The climate crisis, as most everyone in the climate community knows, is upon us. Still, the pace of our response has been profoundly inadequate, so this paper will begin with the blunt truth. The science now tells us that we're pushing beyond mere 'dangerous anthropogenic interference with the climate system', and are rather on the verge of committing to catastrophic interference.« less

Prevalence of the Fibromyalgia Phenotype in Spine Pain Patients Presenting to a Tertiary Care Pain Clinic and the Potential Treatment Implications

PubMed Central

Brummett, Chad M.; Goesling, Jenna; Tsodikov, Alex; Meraj, Taha S.; Wasserman, Ronald A.; Clauw, Daniel J.; Hassett, Afton L.

2014-01-01

Objective Injections for spinal pain have high failure rates, emphasizing the importance of patient selection. It is possible that detecting the presence of a fibromyalgia-like phenotype could aid in prediction, because in these individuals a peripheral injection would not address pain due to alterations in central neurotransmission. We hypothesized that spine pain patients meeting survey criteria for fibromyalgia would be phenotypically distinct from those who do not meet criteria. Methods 548 patients with a primary spine pain diagnosis were studied. All patients completed validated self-report questionnaires, including the Brief Pain Inventory, PainDETECT, Hospital Anxiety and Depression Scale, measures of physical function, and the American College of Rheumatology survey criteria for fibromyalgia. Results 42% met survey criteria for fibromyalgia (FM+). When compared with criteria negative patients, FM+ patients were more likely to be younger, unemployed, receiving compensation, have greater pain intensity, pain interference and neuropathic pain descriptors, as well as higher levels of depression and anxiety, and lower level of physical function (p < 0.0001 for each comparison). Gender, neuropathic pain, pain interference, physical function, and anxiety were independently predictive of fibromyalgia status in a multivariate analysis (p < 0.01, all variables). ROC analysis showed the strength of association of 0.81 as measured by the cross-validated C-statistic. Conclusion Using the survey criteria for fibromyalgia, we demonstrated profound phenotypic differences in a spine pain population. Although centralized pain cannot be confirmed with a survey alone, the pathophysiology of fibromyalgia may help explain a portion of the variability of responses to spine interventions. PMID:24022710

Hospitals push back against reimbursement cuts due to Two-Midnight rule.

PubMed

2016-04-01

The American Hospital Association (AHA) and other hospitals are suing CMS, challenging the 0.2% cut in Medicare reimbursement that CMS instituted to compensate for the financial effect of the Two-Midnight rule. CMS' actuaries reported that inpatient claims are likely to increase under the rule, resulting in $220 million additional reimbursement for hospitals. Hospitals disagree and a study commissioned by the AHA concluded that the CMS study was based on data not available to the public and that data from the Medicare Provider and Analysis Review (MedPAR) would lead to a different conclusion. The AHA suit asks CMS to rescind the cut, restore the base rate for Medicare payments to its previous level, and reimburse hospitals retroactively for the reductions.

Comparison of veterinary drug residue results in animal tissues by ultrahigh-performance liquid chromatography coupled to triple quadrupole or quadrupole-time-of-flight tandem mass spectrometry after different sample preparation methods, including use of a commercial lipid removal product.

PubMed

Anumol, Tarun; Lehotay, Steven J; Stevens, Joan; Zweigenbaum, Jerry

2017-04-01

Veterinary drug residues in animal-derived foods must be monitored to ensure food safety, verify proper veterinary practices, enforce legal limits in domestic and imported foods, and for other purposes. A common goal in drug residue analysis in foods is to achieve acceptable monitoring results for as many analytes as possible, with higher priority given to the drugs of most concern, in an efficient and robust manner. The U.S. Department of Agriculture has implemented a multiclass, multi-residue method based on sample preparation using dispersive solid phase extraction (d-SPE) for cleanup and ultrahigh-performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-QQQ) for analysis of >120 drugs at regulatory levels of concern in animal tissues. Recently, a new cleanup product called "enhanced matrix removal for lipids" (EMR-L) was commercially introduced that used a unique chemical mechanism to remove lipids from extracts. Furthermore, high-resolution quadrupole-time-of-flight (Q/TOF) for (U)HPLC detection often yields higher selectivity than targeted QQQ analyzers while allowing retroactive processing of samples for other contaminants. In this study, the use of both d-SPE and EMR-L sample preparation and UHPLC-QQQ and UHPLC-Q/TOF analysis methods for shared spiked samples of bovine muscle, kidney, and liver was compared. The results showed that the EMR-L method provided cleaner extracts overall and improved results for several anthelmintics and tranquilizers compared to the d-SPE method, but the EMR-L method gave lower recoveries for certain β-lactam antibiotics. QQQ vs. Q/TOF detection showed similar mixed performance advantages depending on analytes and matrix interferences, with an advantage to Q/TOF for greater possible analytical scope and non-targeted data collection. Either combination of approaches may be used to meet monitoring purposes, with an edge in efficiency to d-SPE, but greater instrument robustness and less matrix effects when analyzing EMR-L extracts. Graphical abstract Comparison of cleanup methods in the analysis of veterinary drug residues in bovine tissues.

Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments

PubMed Central

Bargiotas, Panagiotis; Konitsiotis, Spyridon

2013-01-01

Parkinson’s disease therapy is still focused on the use of L-3,4-dihydroxyphenylalanine (levodopa or L-dopa) for the symptomatic treatment of the main clinical features of the disease, despite intensive pharmacological research in the last few decades. However, regardless of its effectiveness, the long-term use of levodopa causes, in combination with disease progression, the development of motor complications termed levodopa-induced dyskinesias (LIDs). LIDs are the result of profound modifications in the functional organization of the basal ganglia circuitry, possibly related to the chronic and pulsatile stimulation of striatal dopaminergic receptors by levodopa. Hence, for decades the key feature of a potentially effective agent against LIDs has been its ability to ensure more continuous dopaminergic stimulation in the brain. The growing knowledge regarding the pathophysiology of LIDs and the increasing evidence on involvement of nondopaminergic systems raises the possibility of more promising therapeutic approaches in the future. In the current review, we focus on novel therapies for LIDs in Parkinson’s disease, based mainly on agents that interfere with glutamatergic, serotonergic, adenosine, adrenergic, and cholinergic neurotransmission that are currently in testing or clinical development. PMID:24174877

Exposure to West Nile Virus Increases Bacterial Diversity and Immune Gene Expression in Culex pipiens.

PubMed

Zink, Steven D; Van Slyke, Greta A; Palumbo, Michael J; Kramer, Laura D; Ciota, Alexander T

2015-10-27

Complex interactions between microbial residents of mosquitoes and arboviruses are likely to influence many aspects of vectorial capacity and could potentially have profound effects on patterns of arbovirus transmission. Such interactions have not been well studied for West Nile virus (WNV; Flaviviridae, Flavivirus) and Culex spp. mosquitoes. We utilized next-generation sequencing of 16S ribosomal RNA bacterial genes derived from Culex pipiens Linnaeus following WNV exposure and/or infection and compared bacterial populations and broad immune responses to unexposed mosquitoes. Our results demonstrate that WNV infection increases the diversity of bacterial populations and is associated with up-regulation of classical invertebrate immune pathways including RNA interference (RNAi), Toll, and Jak-STAT (Janus kinase-Signal Transducer and Activator of Transcription). In addition, WNV exposure alone, without the establishment of infection, results in similar alterations to microbial and immune signatures, although to a lesser extent. Multiple bacterial genera were found in greater abundance inWNV-exposed and/or infected mosquitoes, yet the most consistent and notable was the genus Serratia.

Exploring Divisibility and Summability of 'Photon' Wave Packets in Nonlinear Optical Phenomena

NASA Technical Reports Server (NTRS)

Prasad, Narasimha; Roychoudhuri, Chandrasekhar

2009-01-01

Formulations for second and higher harmonic frequency up and down conversions, as well as multi photon processes directly assume summability and divisibility of photons. Quantum mechanical (QM) interpretations are completely congruent with these assumptions. However, for linear optical phenomena (interference, diffraction, refraction, material dispersion, spectral dispersion, etc.), we have a profound dichotomy. Most optical engineers innovate and analyze all optical instruments by propagating pure classical electromagnetic (EM) fields using Maxwell s equations and gives only lip-service to the concept "indivisible light quanta". Further, irrespective of linearity or nonlinearity of the phenomena, the final results are always registered through some photo-electric or photo-chemical effects. This is mathematically well modeled by a quadratic action (energy absorption) relation. Since QM does not preclude divisibility or summability of photons in nonlinear & multi-photon effects, it cannot have any foundational reason against these same possibilities in linear optical phenomena. It implies that we must carefully revisit the fundamental roots behind all light-matter interaction processes and understand the common origin of "graininess" and "discreteness" of light energy.

Pharmacological interference with tissue hypercatabolism in tumour-bearing rats.

PubMed Central

Tessitore, L; Costelli, P; Baccino, F M

1994-01-01

Marked loss of body weight and profound waste of both skeletal muscle and white adipose tissue occur in rats into which the ascites hepatoma Yoshida AH-130 has been transplanted, associated with marked perturbations in the hormonal homoeostasis and the presence of circulating tumour necrosis factor and high plasma levels of prostaglandin E2 [Tessitore, Costelli and Baccino (1993) Br. J. Cancer 67, 15-23]. On the basis of previous findings, the present study examined whether the development of cachexia in this model system could be significantly affected by adrenalectomy or by pharmacological treatments that may interfere with proximal or distal mediators of tissue hypercatabolism. In no instance was tumour growth modified. Medroxyprogesterone acetate, an anabolic-hormone-like drug, was completely ineffective. In adrenalectomized animals, although changes such as the elevation of plasma triacylglycerols and corticosterone were corrected, the general course of cachexia was not modified. A partial prevention of muscle waste was observed with acetylsalicylic acid, a non-steroidal anti-inflammatory drug, or with leupeptin, a proteinase inhibitor. Insulin afforded the most significant preservation of muscle protein and adipose-tissue mass, which were maintained close to control values even 10 days after transplantation. The effects of insulin on gastrocnemius muscle and liver protein content were exerted by slowing down protein turnover, mainly enhancing synthesis. Consistently, the total free amino acid concentration in the gastrocnemius of insulin-treated rats 10 days after tumour transplantation was close to that of controls. Although treatment with insulin decreased plasma corticosterone to normal values, it did not modify the circulating level of tumour necrosis factor. On the whole these data show that it seems possible to prevent, at least in part, the tissue waste that characterizes cancer cachexia by purely pharmacological means. PMID:8166661

Variation in vasopressin receptor Avpr1a) expression creates diversity in behaviors related to monogamy in prairie voles

PubMed Central

Barrett, Catherine E.; Keebaugh, Alaine C.; Ahern, Todd H.; Bass, Caroline E.; Terwilliger, Ernest F.; Young, Larry J.

2013-01-01

Polymorphisms in noncoding regions of the vasopressin 1a receptor gene (Avpr1a) are associated with a variety of socioemotional characteristics in humans, chimpanzees, and voles, and may impact behavior through site-specific variation in gene expression. The socially monogamous prairie vole offers a unique opportunity to study such neurobiological control of individual differences in complex behavior. Vasopressin 1a receptor (V1aR) signaling is necessary for the formation of the pair bond in males, and prairie voles exhibit greater V1aR binding in the reward-processing ventral pallidum than do asocial voles of the same genus. Diversity in social behavior within prairie voles has been correlated to natural variation in neuropeptide receptor expression in specific brain regions. Here we use RNA interference to examine the causal relationship between intraspecific variation in V1aR and behavioral outcomes, by approximating the degree of naturalistic variation in V1aR expression. Juvenile male prairie voles were injected with viral vectors expressing shRNA sequences targeting Avpr1a mRNA into the ventral pallidum. Down-regulation of pallidal V1aR density resulted in a significant impairment in the preference for a mated female partner and a reduction in anxiety-like behavior in adulthood. No effect on alloparenting was detected. These data demonstrate that within-species naturalistic-like variation in V1aR expression has a profound effect on individual differences in social attachment and emotionality. RNA interference may prove a useful technique to unite the fields of behavioral ecology and neurogenetics to perform ethologically relevant studies of the control of individual variation and offer insight into the evolutionary mechanisms leading to behavioral diversity. PMID:23370363

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis.

PubMed

Cristofanon, S; Abhari, B A; Krueger, M; Tchoghandjian, A; Momma, S; Calaminus, C; Vucic, D; Pichler, B J; Fulda, S

2015-04-16

This study aims at evaluating the combination of the tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL)-receptor 2 (TRAIL-R2)-specific antibody Drozitumab and the Smac mimetic BV6 in preclinical glioblastoma models. To this end, the effect of BV6 and/or Drozitumab on apoptosis induction and signaling pathways was analyzed in glioblastoma cell lines, primary glioblastoma cultures and glioblastoma stem-like cells. Here, we report that BV6 and Drozitumab synergistically induce apoptosis and reduce colony formation in several glioblastoma cell lines (combination index<0.1). Also, BV6 profoundly enhances Drozitumab-induced apoptosis in primary glioblastoma cultures and glioblastoma stem-like cells. Importantly, BV6 cooperates with Drozitumab to suppress tumor growth in two glioblastoma in vivo models including an orthotopic, intracranial mouse model, underlining the clinical relevance of these findings. Mechanistic studies reveal that BV6 and Drozitumab act in concert to trigger the formation of a cytosolic receptor-interacting protein (RIP) 1/Fas-associated via death domain (FADD)/caspase-8-containing complex and subsequent activation of caspase-8 and -3. BV6- and Drozitumab-induced apoptosis is blocked by the caspase inhibitor zVAD.fmk, pointing to caspase-dependent apoptosis. RNA interference-mediated silencing of RIP1 almost completely abolishes the BV6-conferred sensitization to Drozitumab-induced apoptosis, indicating that the synergism critically depends on RIP1 expression. In contrast, both necrostatin-1, a RIP1 kinase inhibitor, and Enbrel, a TNFα-blocking antibody, do not interfere with BV6/Drozitumab-induced apoptosis, demonstrating that apoptosis occurs independently of RIP1 kinase activity or an autocrine TNFα loop. In conclusion, the rational combination of BV6 and Drozitumab presents a promising approach to trigger apoptosis in glioblastoma, which warrants further investigation.

Differential effects of HTLV-1 Tax oncoprotein on the different estrogen-induced-ER α-mediated transcriptional activities

PubMed Central

Abou-Kandil, Ammar; Eisa, Nora; Jabareen, Azhar; Huleihel, Mahmoud

2016-01-01

ABSTRACT The activated estrogen (E2) receptor α (ERα) is a potent transcription factor that is involved in the activation of various genes by 2 different pathways; a classical and non-classical. In classical pathway, ERα binds directly to E2-responsive elements (EREs) located in the appropriate genes promoters and stimulates their transcription. However, in non-classical pathway, the ERα can indirectly bind with promoters and enhance their activity. For instance, ERα activates BRCA1 expression by interacting with jun/fos complex bound to the AP-1 site in BRCA1 promoter. Interference with the expression and/or functions of BRCA1, leads to high risk of breast or/and ovarian cancer. HTLV-1Tax was found to strongly inhibit BRCA1 expression by preventing the binding of E2–ERα complex to BRCA1 promoter. Here we examined Tax effect on ERα induced activation of genes by the classical pathway by testing its influence on E2-induced expression of ERE promoter-driven luciferase reporter (ERE-Luc). Our findings showed that E2 profoundly stimulated this reporter expression and that HTLV-1Tax significantly induced this stimulation. This result is highly interesting because in our previous study Tax was found to strongly block the E2-ERα-mediated activation of BRCA1 expression. ERα was found to produce a big complex by recruiting various cofactors in the nucleus before binding to the ERE region. We also found that only part of the reqruited cofactors are required for the transcriptional activity of ERα complex. Chip assay revealed that the binding of Tax to the ERα complex, did not interfere with its link to ERE region. PMID:27420286

Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer.

PubMed

Ludwig, Sonja; Floros, Theofanis; Theodoraki, Marie-Nicole; Hong, Chang-Sook; Jackson, Edwin K; Lang, Stephan; Whiteside, Theresa L

2017-08-15

Purpose: Head and neck cancers (HNCs) often induce profound immunosuppression, which contributes to disease progression and interferes with immune-based therapies. Body fluids of patients with HNC are enriched in exosomes potentially engaged in negative regulation of antitumor immune responses. The presence and content of exosomes derived from plasma of patients with HNC are evaluated for the ability to induce immune dysfunction and influence disease activity. Experimental Design: Exosomes were isolated by size-exclusion chromatography from plasma of 38 patients with HNC and 14 healthy donors. Morphology, size, numbers, and protein and molecular contents of the recovered exosomes were determined. Coculture assays were performed to measure exosome-mediated effects on functions of normal human lymphocyte subsets and natural killer (NK) cells. The results were correlated with disease stage and activity. Results: The presence, quantity, and molecular content of isolated, plasma-derived exosomes discriminated patients with HNC with active disease (AD) from those with no evident disease (NED) after oncologic therapies. Exosomes of patients with AD were significantly more effective than exosomes of patients with NED in inducing apoptosis of CD8 + T cells, suppression of CD4 + T-cell proliferation, and upregulation of regulatory T-cell (Treg) suppressor functions (all at P < 0.05). Exosomes of patients with AD also downregulated NKG2D expression levels in NK cells. Conclusions: Exosomes in plasma of patients with HNC carry immunosuppressive molecules and interfere with functions of immune cells. Exosome-induced immune suppression correlates with disease activity in HNC, suggesting that plasma exosomes could be useful as biomarkers of HNC progression. Clin Cancer Res; 23(16); 4843-54. ©2017 AACR . ©2017 American Association for Cancer Research.

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

PubMed Central

Rice, D; Barone, S

2000-01-01

Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation, synaptogenesis, myelination, and apoptosis). Evidence from numerous sources demonstrates that neural development extends from the embryonic period through adolescence. In general, the sequence of events is comparable among species, although the time scales are considerably different. Developmental exposure of animals or humans to numerous agents (e.g., X-ray irradiation, methylazoxymethanol, ethanol, lead, methyl mercury, or chlorpyrifos) demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity. Different behavioral domains (e.g., sensory, motor, and various cognitive functions) are subserved by different brain areas. Although there are important differences between the rodent and human brain, analogous structures can be identified. Moreover, the ontogeny of specific behaviors can be used to draw inferences regarding the maturation of specific brain structures or neural circuits in rodents and primates, including humans. Furthermore, various clinical disorders in humans (e.g., schizophrenia, dyslexia, epilepsy, and autism) may also be the result of interference with normal ontogeny of developmental processes in the nervous system. Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function. This concern is compounded by the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 8 Figure 9 Figure 12 Figure 14 Figure 16 Figure 17 PMID:10852851

What about ex post facto

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKee, H.C.

This note presents a legal question in an attempt to find an answer. The author hopes that some legal scholar can explain the principle of ex post facto in the US Constitution as it applies to some of the environmental laws. One of the major advantages of the Association is that it provides a forum for communication among members with different backgrounds and experience. An ex post facto law is one that is applied retroactively. Under such a law, a person could be punished for some act that violated a law passed after the act was committed, even though themore » act was legal when committed. The US Constitution prohibits such laws, as will be discussed later. States are also prohibited from enacting ex post facto laws.« less

Wilson v. Kuenzi.

PubMed

1988-05-17

The Supreme Court of Missouri affirmed the Circuit Court's dismissal of wrongful life and wrongful birth claims brought against a physician who failed to advise a pregnant woman of the availability of the amniocentesis test for Down's syndrome. The Supreme Court ruled that the Missouri statute precluding actions for wrongful life and wrongful birth does not apply retroactively. However, the Court refused to recognize the validity of wrongful life or wrongful death actions. The wrongful life action brought by or on behalf of a child is improper because of the difficulty in assessing damages, and the wrongful birth action brought by the child's parents is invalid because of the absence of traditional tort causation, the derivative nature of the cause of action, and the uncertainty in determining whether the mother would have chosen to abort.

Two-Channel Satellite Retrievals of Aerosol Properties: An Overview

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.

1999-01-01

In order to reduce current uncertainties in the evaluation of the direct and indirect effects of tropospheric aerosols on climate on the global scale, it has been suggested to apply multi-channel retrieval algorithms to the full period of existing satellite data. This talk will outline the methodology of interpreting two-channel satellite radiance data over the ocean and describe a detailed analysis of the sensitivity of retrieved aerosol parameters to the assumptions made in different retrieval algorithms. We will specifically address the calibration and cloud screening issues, consider the suitability of existing satellite data sets to detecting short- and long-term regional and global changes, compare preliminary results obtained by several research groups, and discuss the prospects of creating an advanced retroactive climatology of aerosol optical thickness and size over the oceans.

Analyses of Public Utility Building - Students Designs, Aimed at their Energy Efficiency Improvement

NASA Astrophysics Data System (ADS)

Wołoszyn, Marek Adam

2017-10-01

Public utility buildings are formally, structurally and functionally complex entities. Frequently, the process of their design involves the retroactive reconsideration of energy engineering issues, once a building concept has already been completed. At that stage, minor formal corrections are made along with the design of the external layer of the building in order to satisfy applicable standards. Architecture students do the same when designing assigned public utility buildings. In order to demonstrate energy-related defects of building designs developed by students, the conduct of analyses was proposed. The completed designs of public utility buildings were examined with regard to energy efficiency of the solutions they feature through the application of the following programs: Ecotect, Vasari, and in case of simpler analyses ArchiCad program extensions were sufficient.

Distribution of Auditory Response Behaviors in Normal Infants and Profoundly Multihandicapped Children.

ERIC Educational Resources Information Center

Flexer, Carol; Gans, Donald P.

1986-01-01

A study compared the responsiveness to sound by normal infants and profoundly multihandicapped children. Results revealed that the profoundly multihandicapped subjects displayed relatively more reflexive than attentive type behaviors and exhibited fewer behaviors per response. (Author/CB)

Misperceiving Bullshit as Profound Is Associated with Favorable Views of Cruz, Rubio, Trump and Conservatism

PubMed Central

Pfattheicher, Stefan; Schindler, Simon

2016-01-01

The present research investigates the associations between holding favorable views of potential Democratic or Republican candidates for the US presidency 2016 and seeing profoundness in bullshit statements. In this contribution, bullshit is used as a technical term which is defined as communicative expression that lacks content, logic, or truth from the perspective of natural science. We used the Bullshit Receptivity scale (BSR) to measure seeing profoundness in bullshit statements. The BSR scale contains statements that have a correct syntactic structure and seem to be sound and meaningful on first reading but are actually vacuous. Participants (N = 196; obtained via Amazon Mechanical Turk) rated the profoundness of bullshit statements (using the BSR) and provided favorability ratings of three Democratic (Hillary Clinton, Martin O’Malley, and Bernie Sanders) and three Republican candidates for US president (Ted Cruz, Marco Rubio, and Donald Trump). Participants also completed a measure of political liberalism/conservatism. Results revealed that favorable views of all three Republican candidates were positively related to judging bullshit statements as profound. The smallest correlation was found for Donald Trump. Although we observe a positive association between bullshit and support for the three Democrat candidates, this relationship is both substantively small and statistically insignificant. The general measure of political liberalism/conservatism was also related to judging bullshit statements as profound in that individuals who were more politically conservative had a higher tendency to see profoundness in bullshit statements. Of note, these results were not due to a general tendency among conservatives to see profoundness in everything: Favorable views of Republican candidates and conservatism were not significantly related to profoundness ratings of mundane statements. In contrast, this was the case for Hillary Clinton and Martin O’Malley. Overall, small-to-medium sized correlations were found, indicating that far from all conservatives see profoundness in bullshit statements. PMID:27128318

Misperceiving Bullshit as Profound Is Associated with Favorable Views of Cruz, Rubio, Trump and Conservatism.

PubMed

Pfattheicher, Stefan; Schindler, Simon

2016-01-01

The present research investigates the associations between holding favorable views of potential Democratic or Republican candidates for the US presidency 2016 and seeing profoundness in bullshit statements. In this contribution, bullshit is used as a technical term which is defined as communicative expression that lacks content, logic, or truth from the perspective of natural science. We used the Bullshit Receptivity scale (BSR) to measure seeing profoundness in bullshit statements. The BSR scale contains statements that have a correct syntactic structure and seem to be sound and meaningful on first reading but are actually vacuous. Participants (N = 196; obtained via Amazon Mechanical Turk) rated the profoundness of bullshit statements (using the BSR) and provided favorability ratings of three Democratic (Hillary Clinton, Martin O'Malley, and Bernie Sanders) and three Republican candidates for US president (Ted Cruz, Marco Rubio, and Donald Trump). Participants also completed a measure of political liberalism/conservatism. Results revealed that favorable views of all three Republican candidates were positively related to judging bullshit statements as profound. The smallest correlation was found for Donald Trump. Although we observe a positive association between bullshit and support for the three Democrat candidates, this relationship is both substantively small and statistically insignificant. The general measure of political liberalism/conservatism was also related to judging bullshit statements as profound in that individuals who were more politically conservative had a higher tendency to see profoundness in bullshit statements. Of note, these results were not due to a general tendency among conservatives to see profoundness in everything: Favorable views of Republican candidates and conservatism were not significantly related to profoundness ratings of mundane statements. In contrast, this was the case for Hillary Clinton and Martin O'Malley. Overall, small-to-medium sized correlations were found, indicating that far from all conservatives see profoundness in bullshit statements.

The educational settings of profoundly deaf children with cochlear implants compared with age-matched peers with hearing aids: implications for management.

PubMed

Archbold, Sue M; Nikolopoulos, Thomas P; Lutman, Mark E; O'Donoghue, Gerard M

2002-04-01

The educational settings of 42 implanted profoundly deaf children 3 years after implantation were compared with the respective settings of 635 age-matched severely deaf and 511 profoundly deaf children with hearing aids. All implanted children received their implants before beginning school. The results revealed that 3 years after implantation. 38% (16 children) of the implanted profoundly deaf children attended mainstream schools, whereas 57% (24 children) were in a unit, or special class, in a mainstream school, and 5% (two children) were in schools for the deaf. With regard to the age-matched profoundly deaf children with hearing aids, 12% (63 children) attended mainstream schools, whereas 55% (281 children) were in a unit of a mainstream school, and 33% (167 children) were in schools for the deaf. In the group of age-matched severely deaf children, 38% (239 children) attended mainstream schools, whereas 51% (326 children) were in a unit of a mainstream school, and 11% (70 children) were in schools for the deaf. Statistical analysis revealed a highly significant difference between the educational placement of implanted children and hearing-aided profoundly deaf children (p<0.00001), whereas there was no statistically significant difference between implanted children and hearing-aided severely deaf children. In conclusion, implanted profoundly deaf children who have received their implants before beginning school have the same profile of educational placement as aided severely deaf children rather than aided profoundly deaf children of the same age in the UK. This is likely to have significant implications for the future management of profoundly deaf children and to influence future planning of educational support services.

Severe to profound hearing impairment: quality of life, psychosocial consequences and audiological rehabilitation.

PubMed

Carlsson, Per-Inge; Hjaldahl, Jennie; Magnuson, Anders; Ternevall, Elisabeth; Edén, Margareta; Skagerstrand, Åsa; Jönsson, Radi

2015-01-01

To study the quality of life (QoL) and psychosocial consequences in terms of sick leave and audiological rehabilitation given to patients with severe to profound hearing impairment. A retrospective study of data on 2319 patients with severe to profound hearing impairment in The Swedish Quality Register of Otorhinolaryngology, followed by a posted questionnaire including The Hospital Anxiety and Depression Scale (HADS). The results indicate greater levels of anxiety and depression among patients with severe or profound hearing impairment than in the general population, and annoying tinnitus and vertigo had strong negative effects on QoL. The proportion of sick leave differed between the studied dimensions in the study. The proportion of patients who received extended audiological rehabilitation was 38% in the present study. Treatment focused on anxiety, depression, tinnitus and vertigo must be given early in the rehabilitation process in patients with severe or profound hearing impairment. Because sick leave differs greatly within this group of patients, collaboration with the regional Social Insurance Agency is crucial part of the rehabilitation. The study also shows that presently, only a small proportion of patients in Sweden with severe to profound hearing impairment receive extended audiological rehabilitation. Implications for Rehabilitation Greater levels of anxiety and depression have been found among patients with severe or profound hearing impairment than in the general population, and annoying tinnitus and vertigo have strong negative effects on QoL in this group of patients. Only a small proportion of patients with severe to profound hearing impairment receive extended audiological rehabilitation today, including medical, technical and psychosocial efforts. Extended audiological rehabilitation focused on anxiety, depression, tinnitus and vertigo must be given, together with technical rehabilitation, early in the rehabilitation process in patients with severe or profound hearing impairment.

Individuals with Profound Disabilities: Instructional and Assistive Strategies. Third Edition.

ERIC Educational Resources Information Center

Sternberg, Les, Ed.

This collection of 14 essays focuses on the education of individuals with profound disabilities. The essays include: (1) "Individuals with Profound Disabilities: Definitions, Characteristics, and Conceptual Framework" (Les Sternberg); (2) "Creating Environments That Support and Enhance the Lives of All Individuals" (Lucille Zeph); (3) "Biomedical…

A numerical retroaction model relates rocky coast erosion to percolation theory

NASA Astrophysics Data System (ADS)

Sapoval, B.; Baldassarri, A.

2011-12-01

Rocky coasts are estimated to represent 75% of the world's shorelines [1]. We discuss various situations where the formation of rocky coast morphology could be attributed to the retroaction of the coast morphology on the erosive power of the see. In the case of rocky coasts, erosion can spontaneously create irregular seashores. But, in turn, the geometrical irregularity participates to the damping of sea-waves, decreasing the average wave amplitude and erosive power. There may then exist a mutual self-stabilization of the waves amplitude together with the irregular morphology of the coast. A simple model of such stabilization is discussed. It leads, through a complex avalanche dynamics of the earth-sea interface, to the spontaneous appearance of an irregular sea-shore. The final coast morphology is found to depend on the morphology/damping coupling of the coast and on the possible existence of built-in correlations within the coast lithologic properties. In the limit case where the morphology/damping coupling is weak and when the earth lithology distribution exhibit only short range correlations, the process spontaneously build fractal morphologies with a dimension close to 4/3 [2]. This dimension refers to the dimension of the accessible perimeter in percolation theory. However, even rugged but non-fractal sea-coasts morphology may emerge for strong damping or during the erosion process. When the distributions of the lithologies exhibit long range correlations, a variety of complex morphologies are obtained which mimics observed coastline complexity, well beyond simple fractality. This approach, which links erosion of rocky coasts to percolation theory, provide a natural frame to explain the frequent field observation that the statistics of erosion events follow power law behavior. In a somewhat different perspective, the design of breakwaters is suggested to be improved by using global irregular geometry with features sizes of the order of the wave-length of the sea oscillations. [1] R. A. Davis, Jr, D. M. Fitzgerald, Beaches and Coasts,(Blackwell, Oxford 2004). [2] B. Sapoval, A. Baldassarri, A. Gabrielli, Self-stabilized Fractality of Sea-coasts through Erosion, Phys. Rev. Lett. 93, 098501 (2004).

Retro-action model for the erosion of rocky coasts

NASA Astrophysics Data System (ADS)

Sapoval, B.; Baldassarri, A.

2009-12-01

Rocky coasts are estimated to represent 75% of the world’s shorelines [1]. We discuss various situations where the formation of rocky coast morphology could be attributed to the retro-action of the coast morphology on the erosive power of the see. In the case of rocky coasts, erosion can spontaneously create irregular seashores. But, in turn, the geometrical irregularity participates to the damping of sea-waves, decreasing the average wave amplitude and erosive power. There may then exist a mutual self-stabilization of the waves amplitude together with the irregular morphology of the coast. A simple model of such stabilization is discussed. It leads, through a complex dynamics of the earth-sea interface, to the spontaneous appearance of an irregular sea-shore. The final coast morphology is found to depend on the morphology/damping coupling of the coast and on the possible existence of built-in correlations within the coast lithologic properties. This is illustrated in the figure. In the limit case where the morphology/damping coupling is weak and when the earth lithology distribution exhibit only short range correlations, the process spontaneously build fractal morphologies with a dimension close to 4/3 [2]. It is shown that this dimension refers to the dimension of the so-called accessible perimeter in gradient percolation. However, even rugged but non-fractal sea-coasts morphology may emerge for strong damping or during the erosion process. When the distributions of the lithologies exhibit long range correlations, a variety of complex morphologies are obtained which mimics observed coastline complexity, well beyond simple fractality. On a somewhat different perspective, the design of breakwaters is suggested to be improved by using global irregular geometry with features sizes of the order of the wave-length of the sea oscillations. [1] R. A. Davis, Jr, D. M. Fitzgerald, Beaches and Coasts,(Blackwell, Oxford 2004). [2] B. Sapoval, A. Baldassarri, A. Gabrielli, Self-stabilized Fractality of Sea-coasts through Erosion, Phys. Rev. Lett. 93, 098501 (2004). Time evolution of the coastline morphology starting with a flat sea-shore. Left and right columns correspond respectively to weak and strong coupling. Top to bottom: suc- cessive morphologies with the final morphologies at the bottom.

Teaching Individuals with Profound Multiple Disabilities to Access Preferred Stimuli with Multiple Microswitches

ERIC Educational Resources Information Center

Tam, Gee May; Phillips, Katrina J.; Mudford, Oliver C.

2011-01-01

We replicated and extended previous research on microswitch facilitated choice making by individuals with profound multiple disabilities. Following an assessment of stimulus preferences, we taught 6 adults with profound multiple disabilities to emit 2 different responses to activate highly preferred stimuli. All participants learnt to activate…

The impact of visual impairment on the ability to perform activities of daily living for persons with severe/profound intellectual disability.

PubMed

Dijkhuizen, Annemarie; Hilgenkamp, Thessa I M; Krijnen, Wim P; van der Schans, Cees P; Waninge, Aly

2016-01-01

The ability to perform activities of daily living (ADL) as a component of participation is one of the factors that contribute to quality of life. The ability to perform ADL for persons experiencing severe/profound intellectual disability (ID) may be reduced due to their cognitive and physical capacities. However, until recently, the impact of the significantly prevalent visual impairments on the performance of activities of daily living has not yet been revealed within this group. The purpose of this prospective cross-sectional study was to investigate the impact of visual impairment on the performance of activities of daily living for persons with a severe/profound intellectual disability. The Barthel Index (BI) and Comfortable Walking Speed (CWS) were used to measure the ability of performing activities of daily living (ADL) in 240 persons with severe/profound ID and having Gross Motor Functioning Classification System (GMFCS) levels I, II or III; this included 120 persons with visual impairment. The impact of visual impairment on ADL was analyzed with linear regression. The results of the study demonstrated that visual impairment slightly affects the ability of performing activities of daily living (BI) for persons experiencing a severe/profound intellectual disability. GMFCS Levels II or III, profound ID level, and visual impairment each have the effect of lowering BI scores. GMFCS Levels II or III, and profound ID level each have the effect of increasing CWS scores, which indicates a lower walking speed. A main effect of visual impairment is present on CWS, but our results do show a substantive interaction effect between GMFCS level III and visual impairment on Comfortable Walking Speed in persons with a severe/profound intellectual disability. Visual impairment has a slight effect on ability to perform ADL in persons experiencing severe/profound ID. Copyright © 2015 Elsevier Ltd. All rights reserved.

Acetylcholine-modulated plasticity in reward-driven navigation: a computational study.

PubMed

Zannone, Sara; Brzosko, Zuzanna; Paulsen, Ole; Clopath, Claudia

2018-06-21

Neuromodulation plays a fundamental role in the acquisition of new behaviours. In previous experimental work, we showed that acetylcholine biases hippocampal synaptic plasticity towards depression, and the subsequent application of dopamine can retroactively convert depression into potentiation. We also demonstrated that incorporating this sequentially neuromodulated Spike-Timing-Dependent Plasticity (STDP) rule in a network model of navigation yields effective learning of changing reward locations. Here, we employ computational modelling to further characterize the effects of cholinergic depression on behaviour. We find that acetylcholine, by allowing learning from negative outcomes, enhances exploration over the action space. We show that this results in a variety of effects, depending on the structure of the model, the environment and the task. Interestingly, sequentially neuromodulated STDP also yields flexible learning, surpassing the performance of other reward-modulated plasticity rules.

Physical therapy mandates by Medicare administrative contractors: effective or wasteful?

PubMed

Fehring, Thomas K; Fehring, Keith; Odum, Susan M; Halsey, David

2013-10-01

Documentation of medical necessity for arthroplasty has come under scrutiny by Medicare. In some jurisdictions three months of physical therapy prior to arthroplasty has been mandated. The purpose of this study was to determine the efficacy and cost of this policy to treat advanced osteoarthritis. A systematic review was performed to assimilate efficacy data for physical therapy in patients with advanced osteoarthritis. The number of arthroplasties performed annually was obtained to calculate cost. Evidence-based studies documenting the efficacy of physical therapy in treating advanced arthritis are lacking with a potential cost of 36-68 million dollars. Physical therapy mandates by administrative contractors are not only ineffective but are costly without patient benefit. Medical necessity documentation should be driven by orthopedists not retroactively by Medicare contractors. Copyright © 2013 Elsevier Inc. All rights reserved.

Testing an earthquake prediction algorithm

USGS Publications Warehouse

Kossobokov, V.G.; Healy, J.H.; Dewey, J.W.

1997-01-01

A test to evaluate earthquake prediction algorithms is being applied to a Russian algorithm known as M8. The M8 algorithm makes intermediate term predictions for earthquakes to occur in a large circle, based on integral counts of transient seismicity in the circle. In a retroactive prediction for the period January 1, 1985 to July 1, 1991 the algorithm as configured for the forward test would have predicted eight of ten strong earthquakes in the test area. A null hypothesis, based on random assignment of predictions, predicts eight earthquakes in 2.87% of the trials. The forward test began July 1, 1991 and will run through December 31, 1997. As of July 1, 1995, the algorithm had forward predicted five out of nine earthquakes in the test area, which success ratio would have been achieved in 53% of random trials with the null hypothesis.

Systems Maturity Assessment of the Lithium Ion Battery for Extravehicular Mobility Unit Project

NASA Technical Reports Server (NTRS)

Russell, Samuel P.

2011-01-01

The Long Life (Lithium Ion) Battery (LLB/LIB) is designed to replace the current Extravehicular Mobility Unit (EMU) Silver/Zinc (Ag/Zn) Increased Capacity Battery (ICB), which is used to provide power to the Primary Life Support Subsystem (PLSS) during Extravehicular Activities (EVAs). The LLB (a battery based on commercial lithium ion cell technology) is designed to have the same electrical and mechanical interfaces as the current ICB. The EMU LIB Charger is designed to charge, discharge, and condition the LLB either in a charger-strapped configuration or in an EMU-mounted configuration. This paper will retroactively apply the principles of Systems Maturity Assessment to the LLB project through use of the Integration Readiness Level and Earned Readiness Management. The viability of this methodology will be considered for application to new and existing technology development projects.

Method for Direct Measurement of Cosmic Acceleration by 21-cm Absorption Systems

NASA Astrophysics Data System (ADS)

Yu, Hao-Ran; Zhang, Tong-Jie; Pen, Ue-Li

2014-07-01

So far there is only indirect evidence that the Universe is undergoing an accelerated expansion. The evidence for cosmic acceleration is based on the observation of different objects at different distances and requires invoking the Copernican cosmological principle and Einstein's equations of motion. We examine the direct observability using recession velocity drifts (Sandage-Loeb effect) of 21-cm hydrogen absorption systems in upcoming radio surveys. This measures the change in velocity of the same objects separated by a time interval and is a model-independent measure of acceleration. We forecast that for a CHIME-like survey with a decade time span, we can detect the acceleration of a ΛCDM universe with 5σ confidence. This acceleration test requires modest data analysis and storage changes from the normal processing and cannot be recovered retroactively.

The Deaf-Blind/Severely-Profoundly Handicapped: Proceedings from the 1978 Nebraska Statewide Conference, Nebraska Diagnostic Resource Center, Cozad, Nebraska.

ERIC Educational Resources Information Center

Clark, Douglas H., Ed.

The report presents the proceedings of a 1978 Nebraska statewide conference intitled "The Education and Training of the Deaf-Blind/Severely-Profoundly Handicapped." Titles and authors of the 13 papers presented include "Considerations for Full Educational Service for the Severely and Profoundly Handicapped" (N. Haring);…

Profound Bilateral Sensorineural Hearing Loss in Nigerian Children: Any Shift in Etiology?

ERIC Educational Resources Information Center

Dunmade, A. D.; Segun-Busari, S.; Olajide, T. G.; Ologe, F. E.

2007-01-01

Deafness, profound hearing loss, is a global problem. However, the causes of, attitudes toward, and management options for deafness differ considerably from region to region. This study seeks to identify the present causes of profound sensorineural hearing loss in Nigeria, which in our environment is almost synonymous to a life sentence of silence…

An Examination of Specific Daily Living Skills Deficits in Adults with Profound Intellectual Disabilities

ERIC Educational Resources Information Center

Belva, Brian C.; Matson, Johnny L.

2013-01-01

While some researchers have investigated daily living skills deficits in individuals with intellectual disability (ID) as a whole, research on specific daily living skills in a profound ID population is limited. Two hundred and four adults with profound ID residing in two large developmental centers in the southeast portion of the United States…

Behavioral and Psychosocial Outcomes of a 16-Week Rebound Therapy-Based Exercise Program for People with Profound Intellectual Disabilities

ERIC Educational Resources Information Center

Jones, Martyn C.; Walley, Robert M.; Leech, Amanda; Paterson, Marion; Common, Stephanie; Metcalf, Charlotte

2007-01-01

People with profound intellectual disabilities rarely experience a physically active lifestyle, and their long-term physical inactivity likely contributes to poor health. The authors developed and implemented a pilot exercise program for persons with a profound intellectual disability and conducted a study to evaluate the effort. The development…

Sleep Studies of Adults with Severe or Profound Mental Retardation and Epilepsy.

ERIC Educational Resources Information Center

Espie, Colin A.; Paul, Audrey; McFie, Joyce; Amos, Pat; Hamilton, David; McColl, John H.; And Others

1998-01-01

A study of the sleep patterns of 28 people with severe or profound mental retardation and epilepsy found atypical sleep stages with significant depletion of REM sleep and a predominance of indiscriminate non-REM sleep. Sleep diaries completed by caregivers reveal lengthy sleep periods, especially among those with profound mental retardation.…

ProFound: Source Extraction and Application to Modern Survey Data

NASA Astrophysics Data System (ADS)

Robotham, A. S. G.

2018-04-01

ProFound detects sources in noisy images, generates segmentation maps identifying the pixels belonging to each source, and measures statistics like flux, size, and ellipticity. These inputs are key requirements of ProFit (ascl:1612.004), our galaxy profiling package; these two packages used in unison semi-automatically profile large samples of galaxies. The key novel feature introduced in ProFound is that all photometry is executed on dilated segmentation maps that fully contain the identifiable flux, rather than using more traditional circular or ellipse-based photometry. Also, to be less sensitive to pathological segmentation issues, the de-blending is made across saddle points in flux. ProFound offers good initial parameter estimation for ProFit, and also segmentation maps that follow the sometimes complex geometry of resolved sources, whilst capturing nearly all of the flux. A number of bulge-disc decomposition projects are already making use of the ProFound and ProFit pipeline.

Interference with daily activities and major adverse events during esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter: a systematic review of randomized controlled trials.

PubMed

Iluyomade, A; Olowoyeye, A; Fadahunsi, O; Thomas, L; Libend, C N; Ragunathan, K; Fenster, J; Vignesh, S

2017-02-01

For three decades, ambulatory 24-hour intranasal pH monitoring has been the established gold standard for detecting acid reflux in patients with refractory gastroesophageal reflux disease. However, device-associated adverse events and unpleasant experiences, reported by patients during pH monitoring have led to the invention of more convenient pH monitors such as Bravo wireless capsule. To compare the interference with daily activities and major adverse events during pH monitoring with Bravo wireless capsule (Bravo) versus conventional intranasal catheter (catheter), PubMed, Cochrane Library, Clinical Trials.gov, and Google Scholar were searched up to March 20, 2015. Only randomized controlled trials in adult patients that compared the interference with routine daily activities and adverse events between Bravo and catheter pH monitors were included. After screening 574 articles, three unique studies with 167 patients met our inclusion criteria. The average age of patients enrolled in these studies was 51 years. Interference with normal daily activities was more in the catheter than Bravo group: 75 ± 5 versus 92 ± 2, P < 0.001 (Andrews et al, findings were reported as100 mm, mean visual analogue scale (VAS) ± standard error of the mean, 100 = completely normal); Wong et al. (mean ± standard error of the mean): 1.3 ± 0.2 versus 0.32 ± 0.1, P = 0.001 and Wenner et al. using 10 cm median VAS (Interquartile range),10 been the worst is 5.7 (2.3-8.0) compared to 0.7 (0.2-3.4), P < 0.0001, respectively. Overall adverse events were more in the catheter group than Bravo (39 ± 4 vs. 26 ± 4, P = 0.012 for Andrews et al. (100 been the worst) and 5.1 (2.0-6.6) vs. 2.1 (0.5-4.6), P < 0.001 for Wenner et al.). No overall adverse events recorded for Wong et al. Most patients in catheter group complained of nasal and throat symptoms. Significantly, runny nose in 24 out of 25 patients (96%) catheter versus 13 out of 25 (52%) Bravo, P = 0.001 and nose pain 15 out 25 (60%) versus 8 out of 25 patients (32%), P = 0.047, respectively for Wong et al. Andrews and Wenner et al also showed profound nasal discomforts in catheter group compared to Bravo (39 ± 3 vs. 10 ± 3, P < 0.001 and 6.5 (1.5-8.0) versus 0.2 (0.0-1.9), P < 0.0001, respectively. Throat symptoms reported in Wong et al. were mainly throat discomfort in catheter group 23 out of 25 patients (92%) versus Bravo 12 out of 25 (48%), P = 0.001 and throat pain catheter (12 out of 25 patients (48%) vs. Bravo 4 out of 25 (16%)), P = 0.032. This trend was also observed in Andrews et al. with profound throat discomfort in the catheter group 43 ± 4 compared to Bravo 19 ± 4, P < 0.001. Majority of the patients randomized to Bravo group reportedly perceived chest pain higher than those in catheter group; 9 out of 25 patients (36%) versus 2 out of 25 (8%), P = 0.037 in Wong et al. 29 ± 4 versus 14 ± 3, P = 0.001 for Andrews et al., 2.4 (0.3-5.9) versus 1.1 (0.3-2.9), P = 0.084 in Wenner et al. respectively (though not statistically significant). Bravo wireless capsule pH monitor interfered less with daily activities and adverse events were minimal compared to conventional intranasal catheter. © 2016 International Society for Diseases of the Esophagus.

Domains of Quality of Life of People with Profound Multiple Disabilities: The Perspective of Parents and Direct Support Staff

ERIC Educational Resources Information Center

Petry, Katja; Maes, Bea; Vlaskamp, Carla

2005-01-01

Background: This study considered the general validity of the basic domains of quality of life that appear in theoretical models, in relation to people with profound multiple disabilities. The authors examined how parents and direct support staff operationalized these basic domains for people with profound multiple disabilities. They investigated…

Decreasing Self-Stimulating Behaviors with the Profoundly Mentally Retarded, While Acknowledging Obstacles and Frustrations.

ERIC Educational Resources Information Center

Smith, Susan J.; Solimani, Genevieve

Two studies examined different treatment procedures to suppress self-stimulating behaviors with the profoundly mentally retarded. In experiment 1, a fine mist of cold water from a spray bottle was applied to the neck of a teenaged student in a class for the profoundly retarded. The intervention was very successful in reducing inappropriate humming…

CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?

PubMed

Moukambi, Félicien; Rodrigues, Vasco; Fortier, Yasmina; Rabezanahary, Henintsoa; Borde, Chloé; Krust, Bernard; Andreani, Guadalupe; Silvestre, Ricardo; Petrovas, Constantinos; Laforge, Mireille; Estaquier, Jérôme

2017-01-01

Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection.

CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?

PubMed Central

Moukambi, Félicien; Rodrigues, Vasco; Fortier, Yasmina; Rabezanahary, Henintsoa; Borde, Chloé; Krust, Bernard; Andreani, Guadalupe; Silvestre, Ricardo; Petrovas, Constantinos; Laforge, Mireille; Estaquier, Jérôme

2017-01-01

Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection. PMID:28265271

The Stroop color-word test: influence of age, sex, and education; and normative data for a large sample across the adult age range.

PubMed

Van der Elst, Wim; Van Boxtel, Martin P J; Van Breukelen, Gerard J P; Jolles, Jelle

2006-03-01

The Stroop Color-Word Test was administered to 1,856 cognitively screened, healthy Dutch speaking participants aged 24 to 81 years. The effects of age, gender, and education on Stroop test performance were investigated to adequately stratify the normative data. The results showed that especially the speed-dependent Stroop scores (time to complete a subtest), rather than the accuracy measures (the errors made per Stroop sub-task), were profoundly affected by the demographic variables. In addition to the main effects of the demographic variables, an Age Low Level of Education interaction was found for the Error III and the Stroop Interference scores. This suggests that executive function, as measured by the Stroop test, declines with age and that the decline is more pronounced in people with a low level of education. This is consistent with the reserve hypothesis of brain aging (i.e., that education generates reserve capacity against the damaging effects of aging on brain functions). Normative Stroop data were established using both a regression-based and traditional approach, and the appropriateness of both methods for generating normative data is discussed.

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.

PubMed

Rak, Justyna; Foster, Katie; Potrzebowska, Katarzyna; Talkhoncheh, Mehrnaz Safaee; Miharada, Natsumi; Komorowska, Karolina; Torngren, Therese; Kvist, Anders; Borg, Åke; Svensson, Lena; Bonnet, Dominique; Larsson, Jonas

2017-02-23

Adhesion is a key component of hematopoietic stem cell regulation mediating homing and retention to the niche in the bone marrow. Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Knockdown of CYTH1 disrupted adhesion of HSPCs to primary human mesenchymal stroma cells. Attachment to fibronectin and ICAM1, 2 integrin ligands, was severely impaired, and CYTH1-deficient cells showed a reduced integrin β1 activation response, suggesting that CYTH1 mediates integrin-dependent functions. Transplantation of CYTH1-knockdown cells to immunodeficient mice resulted in significantly lower long-term engraftment levels, associated with a reduced capacity of the transplanted cells to home to the bone marrow. Intravital microscopy showed that CYTH1 deficiency profoundly affects HSPC mobility and localization within the marrow space and thereby impairs proper lodgment into the niche. Thus, CYTH1 is a novel major regulator of adhesion and engraftment in human HSPCs through mechanisms that, at least in part, involve the activation of integrins. © 2017 by The American Society of Hematology.

Exit of Plasmodium Sporozoites from Oocysts Is an Active Process That Involves the Circumsporozoite Protein

PubMed Central

Wang, Qian; Fujioka, Hisashi; Nussenzweig, Victor

2005-01-01

Plasmodium sporozoites develop within oocysts residing in the mosquito midgut. Mature sporozoites exit the oocysts, enter the hemolymph, and invade the salivary glands. The circumsporozoite (CS) protein is the major surface protein of salivary gland and oocyst sporozoites. It is also found on the oocyst plasma membrane and on the inner surface of the oocyst capsule. CS protein contains a conserved motif of positively charged amino acids: region II-plus, which has been implicated in the initial stages of sporozoite invasion of hepatocytes. We investigated the function of region II-plus by generating mutant parasites in which the region had been substituted with alanines. Mutant parasites produced normal numbers of sporozoites in the oocysts, but the sporozoites were unable to exit the oocysts. In in vitro as well, there was a profound delay, upon trypsin treatment, in the release of mutant sporozoites from oocysts. We conclude that the exit of sporozoites from oocysts is an active process that involves the region II-plus of CS protein. In addition, the mutant sporozoites were not infective to young rats. These findings provide a new target for developing reagents that interfere with the transmission of malaria. PMID:16201021

Pain Assessment in People with Profound Intellectual and Multiple Disabilities; a Pilot Study into the Use of the Pain Behaviour Checklist in Everyday Practice

ERIC Educational Resources Information Center

van der Putten, Annette; Vlaskamp, Carla

2011-01-01

Because of their physical and general health problems, people with a combination of profound intellectual and severe or profound motor disabilities (PIMD) are at risk of pain-related medical conditions. They are fully dependent on support professionals for the detection and accurate interpretation of nonverbal pain behaviour. These professionals…

Implementing Nonlinear Feedback Controllers Using DNA Strand Displacement Reactions.

PubMed

Sawlekar, Rucha; Montefusco, Francesco; Kulkarni, Vishwesh V; Bates, Declan G

2016-07-01

We show how an important class of nonlinear feedback controllers can be designed using idealized abstract chemical reactions and implemented via DNA strand displacement (DSD) reactions. Exploiting chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks, we show how a set of unimolecular and bimolecular reactions can be used to realize input-output dynamics that produce a nonlinear quasi sliding mode (QSM) feedback controller. The kinetics of the required chemical reactions can then be implemented as enzyme-free, enthalpy/entropy driven DNA reactions using a toehold mediated strand displacement mechanism via Watson-Crick base pairing and branch migration. We demonstrate that the closed loop response of the nonlinear QSM controller outperforms a traditional linear controller by facilitating much faster tracking response dynamics without introducing overshoots in the transient response. The resulting controller is highly modular and is less affected by retroactivity effects than standard linear designs.

Taking the liability out of contaminated property transactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayers, K.W.; Taylor, R.J.

Brownfield redevelopment has been one of the hottest environmental topics for the past several years. However, brownfields are only a small segment of the contaminated property transaction market that includes the sale of real estate, signing of leases, and mergers and acquisitions that involve the transfer of property impacted by environmental contamination. Historic site pollution creates problems due to strict, joint and several, and retroactive liability imposed by environmental laws. In response to the interest in contaminated properties, the environmental insurance industry has developed a number of products that cap the remediation costs and supplement or in many instances replacemore » indemnity agreements. These insurance products allow buyers, sellers, and remediation contractors to cap remediation costs, provide long-term warranties, manage balance sheet liabilities, and even allow PRPs to walk away from site cleanup and long-term operation and maintenance obligations.« less

Human error mitigation initiative (HEMI) : summary report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stevens, Susan M.; Ramos, M. Victoria; Wenner, Caren A.

2004-11-01

Despite continuing efforts to apply existing hazard analysis methods and comply with requirements, human errors persist across the nuclear weapons complex. Due to a number of factors, current retroactive and proactive methods to understand and minimize human error are highly subjective, inconsistent in numerous dimensions, and are cumbersome to characterize as thorough. An alternative and proposed method begins with leveraging historical data to understand what the systemic issues are and where resources need to be brought to bear proactively to minimize the risk of future occurrences. An illustrative analysis was performed using existing incident databases specific to Pantex weapons operationsmore » indicating systemic issues associated with operating procedures that undergo notably less development rigor relative to other task elements such as tooling and process flow. Future recommended steps to improve the objectivity, consistency, and thoroughness of hazard analysis and mitigation were delineated.« less

Geoconservation - a southern African and African perspective

NASA Astrophysics Data System (ADS)

Reimold, Wolf Uwe

1999-10-01

In contrast to Europe, where geoconservation is actively pursued in most countries and where two international symposia on this subject have been staged in 1991 and 1996, geoconservation in Africa has indeed a very poor record. Considering the wealth of outstanding geological sites and the importance African stratigraphy has within the global geological record, pro-active geoconservation on this continent has not featured very prominently to date. In the interest of science, education and tourism, unique and typical geosites need to be identified, catalogued, and prioritised with the aim being their protection. Most African countries do not have vibrant non-governmental organisations such as a strong geological society, which could drive projects like geoconservation, or strong support from the private sector for environmental work. Here, a case is made for the role that established National Geological Surveys, some of which are already involved with retroactive environmental geological work, could play in the forefront of pro-active geoconservation and site protection.

Uranium mobility across annual growth rings in three deciduous tree species

DOE Office of Scientific and Technical Information (OSTI.GOV)

McHugh, Kelly C.; Widom, Elisabeth; Spitz, Henry B.

Black walnut (Juglans nigra), slippery elm (Ulmus rubra), and white ash (Fraxinus americana) trees were evaluated as potential archives of past uranium (U) contamination. Like other metals, U mobility in annual growth rings of trees is potentially dependent on the tree species. Uranium concentrations and isotopic compositions (masses 234, 235, 236, and 238) were analyzed by thermal ionization mass spectrometry to test the efficacy of using tree rings to retroactively monitor U pollution from the FFMPC, a U purification facility operating from 1951 to 1989. This study found non-natural U (depleted U and detectable 236U) in growth rings of allmore » three tree species that pre-dated the start of operations at FFMPC and compositional trends that did not correspond with known contamination events. Therefore, the annual growth rings of these tree species cannot be used to reliably monitor the chronology of U contamination.« less

Japanese women's perceptions of intimate partner violence (IPV).

PubMed

Nagae, Miyoko; Dancy, Barbara L

2010-04-01

Intimate partner violence (IPV) is a problem in Japan. The purpose is to describe IPV as perceived by a purposive sample of 11 Japanese adult females who were in a heterosexual marriage at the time of IPV. We used a cross-sectional, retroactive, qualitative description research design with individual, fact-to-face in depth interviews. At the time of the interview, the women had a mean age of 38 years and at the time of the IPV, a mean age of 28 years. Data were analyzed using the directed qualitative content analysis method. The results revealed that all women experienced physical and emotional abuse and 82% experienced sexual abuse. Communication between spouses was characterized as unilateral, with husbands initiating and dominating the conversation. The women identified the culture of the Japanese patriarchal system as directly influencing IPV. The implication is health professionals should actively advocate for effective legislation and policies to address IPV.

Uranium mobility across annual growth rings in three deciduous tree species.

PubMed

McHugh, Kelly C; Widom, Elisabeth; Spitz, Henry B; Wiles, Gregory C; Glover, Sam E

2018-02-01

Black walnut (Juglans nigra), slippery elm (Ulmus rubra), and white ash (Fraxinus americana) trees were evaluated as potential archives of past uranium (U) contamination. Like other metals, U mobility in annual growth rings of trees is dependent on the tree species. Uranium concentrations and isotopic compositions (masses 234, 235, 236, and 238) were analyzed by thermal ionization mass spectrometry to test the efficacy of using tree rings to retroactively monitor U pollution from the FFMPC, a U purification facility operating from 1951 to 1989. This study found non-natural U (depleted U and detectable 236 U) in growth rings of all three tree species that pre-dated the start of operations at FFMPC and compositional trends that did not correspond with known contamination events. Therefore, the annual growth rings of these tree species cannot be used to reliably monitor the chronology of U contamination. Copyright © 2017 Elsevier Ltd. All rights reserved.

Retrospective Revaluation: The Phenomenon and Its Theoretical Implications

PubMed Central

Miller, Ralph R.; Witnauer, James E.

2015-01-01

Retrospective revaluation refers to an increase (or decrease) in responding to conditioned stimulus (CS X) as a result of decreasing (or increasing) the associative strength of another CS (A) with respect to the unconditioned stimulus (i.e., A-US) that was previously trained in compound with the target CS (e.g., AX−US or just AX). We discuss the conditions under which retrospective revaluation phenomena are most apt to be observed and their implications for various models of learning that are able to account for retrospective revaluation (e.g., Dickinson and Burke, 1996; Miller and Matzel, 1988; Van Hamme and Wasserman, 1994). Although retroactive revaluation is relatively parameter specific, it is seen to be a reliable phenomenon observed across many tasks and species. As it is not anticipated by many conventional models of learning (e.g., Rescorla and Wagner, 1972), it serves as a critical benchmark for evaluating traditional and newer models. PMID:26342855

Radon in Wisconsin.

PubMed

Weiffenbach, C; Anderson, H A

2000-11-01

Owners of about 15% to 20% of the homes in Wisconsin have tested their indoor air for the carcinogenic gas radon. Five percent to 10% of homes have year-average main-floor radon levels that exceed the US Environmental Protection Agency (EPA) exposure guideline, and they are found in most regions of the state. Attempting to retroactively seal foundations to keep radon from the ground out of a home is largely ineffective. However, a soil-depressurization radon mitigation system is highly effective for existing houses, and new homes can easily be built radon-resistant. As the number of homeowners obtaining needed repairs increases, significant lung cancer risk reduction is being achieved in a voluntary, non-regulatory setting. In coming years, as radon in community drinking water supplies becomes regulated under the federal 1996 Safe Drinking Water Act, the "multimedia" option of the act may result in additional attention to mitigation of radon in indoor air.

RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells.

PubMed

Nabzdyk, Christoph S; Lancero, Hope; Nguyen, Khanh P; Salek, Sherveen; Conte, Michael S

2011-11-01

Survivin (SVV) is a multifunctional protein that has been implicated in the development of neointimal hyperplasia. Nuclear SVV is essential for mitosis, whereas in mitochondria SVV has a cytoprotective function. Here, we investigated the effects of RNA interference (RNAi)-mediated SVV knockdown on cell cycle kinetics, apoptosis, migration, and gene expression in primary cultured vascular smooth muscle cells (VSMCs) from the human saphenous vein. Primary Human VSMCs were obtained from saphenous veins and cultured under standard conditions. SVV knockdown was achieved by either small interfering RNA or lentiviral transduction of short hairpin RNA, reducing SVV gene expression by quantitative PCR (>75%, P < 0.01) without a loss of cell viability. Subcellular fractionation revealed that RNAi treatment effectively targeted the nuclear SVV pool, whereas the larger mitochondrial pool was much less sensitive to transient knockdown. Both p53 and p27 protein levels were notably increased. SVV RNAi treatment significantly blocked VSMC proliferation in response to serum and PDGF-AB, arresting VSMC growth. Cell cycle analysis revealed an increased G(2)/M fraction consistent with a mitotic defect; 4',6-diamidino-2-phenylindole staining confirmed an increased frequency of polyploid and abnormal nuclei. In a transwell assay, SVV knockdown reduced migration to PDGF-AB, and actin-phalloidin staining revealed disorganized actin filaments and polygonal cell shape. However, apoptosis (DNA content and annexin V flow cytometry) was not directly induced by SVV RNAi, and sensitivity to apoptotic agonists (e.g., staurosporine and cytokines) was unchanged. In conclusion, RNAi-mediated SVV knockdown in VSMCs leads to profound cell cycle arrest at G(2)/M and impaired chemotaxis without cytotoxicity. The regulation of mitosis and apoptosis in VSMC involves differentially regulated subcellular pools of SVV. Thus, treatment of VSMC with RNAi targeting SVV might limit the response to vascular injury without destabilizing the vessel wall.

RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells

PubMed Central

Nabzdyk, Christoph S.; Lancero, Hope; Nguyen, Khanh P.; Salek, Sherveen

2011-01-01

Survivin (SVV) is a multifunctional protein that has been implicated in the development of neointimal hyperplasia. Nuclear SVV is essential for mitosis, whereas in mitochondria SVV has a cytoprotective function. Here, we investigated the effects of RNA interference (RNAi)-mediated SVV knockdown on cell cycle kinetics, apoptosis, migration, and gene expression in primary cultured vascular smooth muscle cells (VSMCs) from the human saphenous vein. Primary Human VSMCs were obtained from saphenous veins and cultured under standard conditions. SVV knockdown was achieved by either small interfering RNA or lentiviral transduction of short hairpin RNA, reducing SVV gene expression by quantitative PCR (>75%, P < 0.01) without a loss of cell viability. Subcellular fractionation revealed that RNAi treatment effectively targeted the nuclear SVV pool, whereas the larger mitochondrial pool was much less sensitive to transient knockdown. Both p53 and p27 protein levels were notably increased. SVV RNAi treatment significantly blocked VSMC proliferation in response to serum and PDGF-AB, arresting VSMC growth. Cell cycle analysis revealed an increased G2/M fraction consistent with a mitotic defect; 4′,6-diamidino-2-phenylindole staining confirmed an increased frequency of polyploid and abnormal nuclei. In a transwell assay, SVV knockdown reduced migration to PDGF-AB, and actin-phalloidin staining revealed disorganized actin filaments and polygonal cell shape. However, apoptosis (DNA content and annexin V flow cytometry) was not directly induced by SVV RNAi, and sensitivity to apoptotic agonists (e.g., staurosporine and cytokines) was unchanged. In conclusion, RNAi-mediated SVV knockdown in VSMCs leads to profound cell cycle arrest at G2/M and impaired chemotaxis without cytotoxicity. The regulation of mitosis and apoptosis in VSMC involves differentially regulated subcellular pools of SVV. Thus, treatment of VSMC with RNAi targeting SVV might limit the response to vascular injury without destabilizing the vessel wall. PMID:21856925

Lactic acid delays the inflammatory response of human monocytes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peter, Katrin, E-mail: katrin.peter@ukr.de; Rehli, Michael, E-mail: michael.rehli@ukr.de; RCI Regensburg Center for Interventional Immunology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg

2015-02-13

Lactic acid (LA) accumulates under inflammatory conditions, e.g. in wounds or tumors, and influences local immune cell functions. We previously noted inhibitory effects of LA on glycolysis and TNF secretion of human LPS-stimulated monocytes. Here, we globally analyze the influence of LA on gene expression during monocyte activation. To separate LA-specific from lactate- or pH-effects, monocytes were treated for one or four hours with LPS in the presence of physiological concentrations of LA, sodium lactate (NaL) or acidic pH. Analyses of global gene expression profiles revealed striking effects of LA during the early stimulation phase. Up-regulation of most LPS-induced genesmore » was significantly delayed in the presence of LA, while this inhibitory effect was attenuated in acidified samples and not detected after incubation with NaL. LA targets included genes encoding for important monocyte effector proteins like cytokines (e.g. TNF and IL-23) or chemokines (e.g. CCL2 and CCL7). LA effects were validated for several targets by quantitative RT-PCR and/or ELISA. Further analysis of LPS-signaling pathways revealed that LA delayed the phosphorylation of protein kinase B (AKT) as well as the degradation of IκBα. Consistently, the LPS-induced nuclear accumulation of NFκB was also diminished in response to LA. These results indicate that the broad effect of LA on gene expression and function of human monocytes is at least partially caused by its interference with immediate signal transduction events after activation. This mechanism might contribute to monocyte suppression in the tumor environment. - Highlights: • Lactic acid broadly delays LPS-induced gene expression in human monocytes. • Expression of important monocyte effector molecules is affected by lactic acid. • Interference of lactic acid with TLR signaling causes the delayed gene expression. • The profound effect of lactic acid might contribute to immune suppression in tumors.« less

When masculinity interferes with women's treatment of HIV infection: a qualitative study about adherence to antiretroviral therapy in Zimbabwe.

PubMed

Skovdal, Morten; Campbell, Catherine; Nyamukapa, Constance; Gregson, Simon

2011-06-09

Social constructions of masculinity have been shown to serve as an obstacle to men's access and adherence to antiretroviral therapies (ART). In the light of women's relative lack of power in many aspects of interpersonal relationships with men in many African settings, our objective is to explore how male denial of HIV/AIDS impacts on their female partners' ability to access and adhere to ART. We conducted a qualitative case study involving thematic analysis of 37 individual interviews and five focus groups with a total of 53 male and female antiretroviral drug users and 25 healthcare providers in rural eastern Zimbabwe. Rooted in hegemonic notions of masculinity, men saw HIV/AIDS as a threat to their manhood and dignity and exhibited a profound fear of the disease. In the process of denying and avoiding their association with AIDS, many men undermine their wives' efforts to access and adhere to ART. Many women felt unable to disclose their HIV status to their husbands, forcing them to take their medication in secret, and act without a supportive treatment partner, which is widely accepted to be vitally important for adherence success. Some husbands, when discovering that their wives are on ART, deny them permission to take the drugs, or indeed steal the drugs for their own treatment. Men's avoidance of HIV also leaves many HIV-positive women feeling vulnerable to re-infection as their husbands, in an attempt to demonstrate their manhood, are believed to continue engaging in HIV-risky behaviours. Hegemonic notions of masculinity can interfere with women's adherence to ART. It is important that those concerned with promoting effective treatment services recognise the gender and household dynamics that may prevent some women from successfully adhering to ART, and explore ways to work with both women and men to identify couples-based strategies to increase adherence to ART.

When masculinity interferes with women's treatment of HIV infection: a qualitative study about adherence to antiretroviral therapy in Zimbabwe

PubMed Central

2011-01-01

Background Social constructions of masculinity have been shown to serve as an obstacle to men's access and adherence to antiretroviral therapies (ART). In the light of women's relative lack of power in many aspects of interpersonal relationships with men in many African settings, our objective is to explore how male denial of HIV/AIDS impacts on their female partners' ability to access and adhere to ART. Methods We conducted a qualitative case study involving thematic analysis of 37 individual interviews and five focus groups with a total of 53 male and female antiretroviral drug users and 25 healthcare providers in rural eastern Zimbabwe. Results Rooted in hegemonic notions of masculinity, men saw HIV/AIDS as a threat to their manhood and dignity and exhibited a profound fear of the disease. In the process of denying and avoiding their association with AIDS, many men undermine their wives' efforts to access and adhere to ART. Many women felt unable to disclose their HIV status to their husbands, forcing them to take their medication in secret, and act without a supportive treatment partner, which is widely accepted to be vitally important for adherence success. Some husbands, when discovering that their wives are on ART, deny them permission to take the drugs, or indeed steal the drugs for their own treatment. Men's avoidance of HIV also leave many HIV-positive women feeling vulnerable to re-infection as their husbands, in an attempt to demonstrate their manhood, are believed to continue engaging in HIV-risky behaviours. Conclusions Hegemonic notions of masculinity can interfere with women's adherence to ART. It is important that those concerned with promoting effective treatment services recognise the gender and household dynamics that may prevent some women from successfully adhering to ART, and explore ways to work with both women and men to identify couples-based strategies to increase adherence to ART PMID:21658260

Capturing the Surface Texture and Shape of Pollen: A Comparison of Microscopy Techniques

PubMed Central

Sivaguru, Mayandi; Mander, Luke; Fried, Glenn; Punyasena, Surangi W.

2012-01-01

Research on the comparative morphology of pollen grains depends crucially on the application of appropriate microscopy techniques. Information on the performance of microscopy techniques can be used to inform that choice. We compared the ability of several microscopy techniques to provide information on the shape and surface texture of three pollen types with differing morphologies. These techniques are: widefield, apotome, confocal and two-photon microscopy (reflected light techniques), and brightfield and differential interference contrast microscopy (DIC) (transmitted light techniques). We also provide a first view of pollen using super-resolution microscopy. The three pollen types used to contrast the performance of each technique are: Croton hirtus (Euphorbiaceae), Mabea occidentalis (Euphorbiaceae) and Agropyron repens (Poaceae). No single microscopy technique provided an adequate picture of both the shape and surface texture of any of the three pollen types investigated here. The wavelength of incident light, photon-collection ability of the optical technique, signal-to-noise ratio, and the thickness and light absorption characteristics of the exine profoundly affect the recovery of morphological information by a given optical microscopy technique. Reflected light techniques, particularly confocal and two-photon microscopy, best capture pollen shape but provide limited information on very fine surface texture. In contrast, transmitted light techniques, particularly differential interference contrast microscopy, can resolve very fine surface texture but provide limited information on shape. Texture comprising sculptural elements that are spaced near the diffraction limit of light (∼250 nm; NDL) presents an acute challenge to optical microscopy. Super-resolution structured illumination microscopy provides data on the NDL texture of A. repens that is more comparable to textural data from scanning electron microscopy than any other optical microscopy technique investigated here. Maximizing the recovery of morphological information from pollen grains should lead to more robust classifications, and an increase in the taxonomic precision with which ancient vegetation can be reconstructed. PMID:22720050

Skill of a global seasonal ensemble streamflow forecasting system

NASA Astrophysics Data System (ADS)

Candogan Yossef, Naze; Winsemius, Hessel; Weerts, Albrecht; van Beek, Rens; Bierkens, Marc

2013-04-01

Forecasting of water availability and scarcity is a prerequisite for managing the risks and opportunities caused by the inter-annual variability of streamflow. Reliable seasonal streamflow forecasts are necessary to prepare for an appropriate response in disaster relief, management of hydropower reservoirs, water supply, agriculture and navigation. Seasonal hydrological forecasting on a global scale could be valuable especially for developing regions of the world, where effective hydrological forecasting systems are scarce. In this study, we investigate the forecasting skill of the global seasonal streamflow forecasting system FEWS-World, using the global hydrological model PCR-GLOBWB. FEWS-World has been setup within the European Commission 7th Framework Programme project Global Water Scarcity Information Service (GLOWASIS). Skill is assessed in historical simulation mode as well as retroactive forecasting mode. The assessment in historical simulation mode used a meteorological forcing based on observations from the Climate Research Unit of the University of East Anglia and the ERA-40 reanalysis of the European Center for Medium-Range Weather Forecasts (ECMWF). We assessed the skill of the global hydrological model PCR-GLOBWB in reproducing past discharge extremes in 20 large rivers of the world. This preliminary assessment concluded that the prospects for seasonal forecasting with PCR-GLOBWB or comparable models are positive. However this assessment did not include actual meteorological forecasts. Thus the meteorological forcing errors were not assessed. Yet, in a forecasting setup, the predictive skill of a hydrological forecasting system is affected by errors due to uncertainty from numerical weather prediction models. For the assessment in retroactive forecasting mode, the model is forced with actual ensemble forecasts from the seasonal forecast archives of ECMWF. Skill is assessed at 78 stations on large river basins across the globe, for all the months of the year and for lead times up to 6 months. The forecasted discharges are compared with observed monthly streamflow records using the ensemble verification measures Brier Skill Score (BSS) and Continuous Ranked Probability Score (CRPS). The eventual goal is to transfer FEWS-World to operational forecasting mode, where the system will use operational seasonal forecasts from ECMWF. The results will be disseminated on the internet, and hopefully provide information that is valuable for users in data and model-poor regions of the world.

ProFound: Source Extraction and Application to Modern Survey Data

NASA Astrophysics Data System (ADS)

Robotham, A. S. G.; Davies, L. J. M.; Driver, S. P.; Koushan, S.; Taranu, D. S.; Casura, S.; Liske, J.

2018-05-01

We introduce PROFOUND, a source finding and image analysis package. PROFOUND provides methods to detect sources in noisy images, generate segmentation maps identifying the pixels belonging to each source, and measure statistics like flux, size, and ellipticity. These inputs are key requirements of PROFIT, our recently released galaxy profiling package, where the design aim is that these two software packages will be used in unison to semi-automatically profile large samples of galaxies. The key novel feature introduced in PROFOUND is that all photometry is executed on dilated segmentation maps that fully contain the identifiable flux, rather than using more traditional circular or ellipse-based photometry. Also, to be less sensitive to pathological segmentation issues, the de-blending is made across saddle points in flux. We apply PROFOUND in a number of simulated and real-world cases, and demonstrate that it behaves reasonably given its stated design goals. In particular, it offers good initial parameter estimation for PROFIT, and also segmentation maps that follow the sometimes complex geometry of resolved sources, whilst capturing nearly all of the flux. A number of bulge-disc decomposition projects are already making use of the PROFOUND and PROFIT pipeline, and adoption is being encouraged by publicly releasing the software for the open source R data analysis platform under an LGPL-3 license on GitHub (github.com/asgr/ProFound).

Noonan Syndrome: An Underestimated Cause of Severe to Profound Sensorineural Hearing Impairment. Which Clues to Suspect the Diagnosis?

PubMed

Ziegler, Alban; Loundon, Natalie; Jonard, Laurence; Cavé, Hélène; Baujat, Geneviève; Gherbi, Souad; Couloigner, Vincent; Marlin, Sandrine

2017-09-01

To highlight Noonan syndrome as a clinically recognizable cause of severe to profound sensorineural hearing impairment. New clinical cases and review. Patients evaluated for etiological diagnosis by a medical geneticist in a reference center for hearing impairment. Five patients presenting with confirmed Noonan syndrome and profound sensorineural hearing impairment. Diagnostic and review of the literature. Five patients presented with profound sensorineural hearing impairment and molecularly confirmed Noonan syndrome. Sensorineural hearing impairment has been progressive for three patients. Cardiac echography identified pulmonary stenosis in two patients and was normal for the three other patients. Short stature was found in two patients. Mild intellectual disability was found in one patient. Inconspicuous clinical features as facial dysmorphism, cryptorchidism, or easy bruising were of peculiar interest to reach the diagnosis of Noonan syndrome. Profound sensorineural hearing impairment can be the main feature of Noonan syndrome. Associated features are highly variable; thus, detailed medical history and careful physical examination are mandatory to consider the diagnosis in case of a sensorineural hearing impairment.

Achieving profound anesthesia using the intraosseous technique.

PubMed

Coury, K A

1997-10-01

The intraosseous technique has been described as a useful adjunct to primary anesthetic administration. It has several advantages (Table 3) over other supplemental techniques in that it is relatively simple to implement into routine practice, it affords fast, predictable results, and it is relatively painless. The technique has been shown to be very successful in achieving profound pulpal anesthesia when administered as a supplement to the inferior alveolar nerve block and is effective in achieving profound anesthesia in irreversibly inflamed teeth, especially mandibular molars.

Fire Safety Training with Adults Who Are Profoundly Mentally Retarded.

ERIC Educational Resources Information Center

Rae, Rosamond; Roll, David

1985-01-01

An intensive fire safety training program for profoundly mentally retarded institutionalized persons resulted in a significant decrease in mean evacuation time and gradual substitution of verbal for physical prompts. (CL)

Kocuria rosea, kocuria kristinae, leuconostoc mesenteroides as caries-causing representatives of oral microflora.

PubMed

Ananieva, Maiia M; Faustova, Mariia O; Basarab, Iaroslav O; Loban', Galina A

2017-01-01

Recently, opportunistic microflora are increasingly known to be involved in the development of pathological processes in various systems and organs. This situation promotes interest in their detailed study as causative agents of bacterial infections. To study the microbial species residing in carious cavities in acute profound caries. The study involved 14 people with a diagnosis of acute profound caries. Microbiological methods included determining species of microorganisms' cultures from carious cavities in acute profound caries. Final identification was carried out by automatic bacteriological analyzer Vitec-2compact bioMérieux. Among the bacteria isolated, Kocuria rosae, Kocuria kristinae, and Leuconostoc mesenteroides are the focus of the authors' attention due to their identification rate in the patients. These microbial species are little studied due to the lack of data on their cariogenic associations.The meticulous study of the microorganisms, isolated from carious cavities in patients with acute profound caries by automatic bacteriological analyzer Vitec-2 Systems bioMérieux, and findings on their biochemical properties allow us to conclude that Kocuria rosae, Kocuria kristinae, and Leuconostoc mesenteroides are among the microorganisms making up the microflora of carious cavities under acute profound caries and are involved in the development of the caries process.

Electrical potential induced switchable wettability of super-aligned carbon nanotube films

NASA Astrophysics Data System (ADS)

Zhang, Guang; Duan, Zheng; Wang, Qinggong; Li, Long; Yao, Wei; Liu, Changhong

2018-01-01

Controlling of the wettability of micro-nano scale surfaces not only plays important roles in basic science but also presents some significant applications in interference shielding materials, microfluidics and phase-change heat transfer enhancement, etc. Here, the superhydrophobic super-aligned carbon nanotube (SACNT) films are firstly obtained by the chemical vapor deposition method and the annealing process. Then their wettabilities are in-situ switched by the electrowetting strategy. Specifically, the fascinating transformation of superhydrophobicity to the superhydrophilicity is achieved by exerting external DC voltages across the CNT-liquid interfaces, and the transitions of Cassie-to-Wenzel states are observed on the multilayer SACNT films. In addition, the electrowetting induced salt absorption of the porous SACNT is also reported here. Finally, the threshold voltages of the electrowetting behaviors for different liquids on the SACNT films and unit capacitances across the CNT-liquid interfaces are obtained, which reveal that the SACNT films have much more outstanding electrowetting properties than the previously reported works. Our approach reported here demonstrates that the wettability of SACNT films could be simply, effectively and in-situ controlled by the electrowetting method, which will have many profound implications in numerous applications such as phase-change heat transfer enhancement, optical lens with variable focal length and microfluidics, etc.

The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.

PubMed

Jin, Huali; Yan, Zhipeng; Prabhakar, Bellur S; Feng, Zongdi; Ma, Yijie; Verpooten, Dustin; Ganesh, Balaji; He, Bin

2010-02-01

Ebola virus causes rapidly progressive haemorrhagic fever, which is associated with severe immuosuppression. In infected dendritic cells (DCs), Ebola virus replicates efficiently and inhibits DC maturation without inducing cytokine expression, leading to impaired T-cell proliferation. However, the underlying mechanism remains unclear. In this study, we report that Ebola virus VP35 impairs the maturation of mouse DCs. When expressed in mouse immature DCs, Ebola virus VP35 prevents virus-stimulated expression of CD40, CD80, CD86 and major histocompatibility complex class II. Further, it suppresses the induction of cytokines such as interleukin (IL)-6, IL-12, tumour necrosis factor alpha and alpha/beta interferon (IFN-alpha/beta). Notably, Ebola VP35 attenuates the ability of DCs to stimulate the activation of CD4(+) T cells. Addition of type I IFN to mouse DCs only partially reverses the inhibitory effects of VP35. Moreover, VP35 perturbs mouse DC functions induced by lipopolysaccharide, an agonist of Toll-like receptor 4. Deletion of the amino terminus abolishes its activity, whereas a mutation in the RNA binding motif has no effect. Our work highlights a critical role of VP35 in viral interference in DC function with resultant deficiency in T-cell function, which may contribute to the profound virulence of Ebola virus infection.

Systemic Inflammatory Response Syndrome After Administration of Unmodified T Lymphocytes

PubMed Central

Papadopoulou, Anastasia; Krance, Robert A; Allen, Carl E; Lee, Daniel; Rooney, Cliona M; Brenner, Malcolm K; Leen, Ann M; Heslop, Helen E

2014-01-01

Systemic inflammatory response syndrome (SIRS) is a rare systemic inflammatory response associated with fever, tachycardia, profound hypotension, and respiratory distress, which has been reported in cancer patients receiving T cells genetically modified with chimeric antigen receptors to retarget their specificity to tumor-associated antigens. The syndrome usually occurs following significant in vivo expansion of the infused cells and has been associated with tumor destruction/lysis. Analysis of patient plasma has shown elevated cytokine levels, and resolution of symptoms has been reported after administration of steroids and/or antibodies (such as anti–tumor necrosis factor and anti-interleukin (IL)-6 receptor antibodies) that interfere with cytokine responses.To date, SIRS has not been reported in subjects receiving genetically unmodified T cells with native receptors directed against tumor antigens, in which greater physiological control of T-cell activation and expansion may occur. Here, however, we report a patient with bulky refractory Epstein-Barr virus (EBV)–associated lymphoma, who developed this syndrome 2 weeks after receiving T cells directed against EBV antigens through their native receptors. She was treated with steroids and etanercept, with rapid resolution of symptoms. SIRS may therefore occur even when T cells recognize antigens physiologically through their “wild-type” native receptors and should be acknowledged as a potential complication of this therapy. PMID:24651135

Low-levels of fluoride in plaque and saliva and their effects on the demineralisation and remineralisation of enamel; role of fluoride toothpastes.

PubMed

Lynch, R J M; Navada, R; Walia, R

2004-01-01

To summarise support for current consensus on the likely means by which fluoride toothpastes reduce caries and review some relevant studies of the effect of low levels of fluoride on the demineralisation and remineralisation of enamel. The major anti-caries effect of fluoride toothpastes is thought to result from small but protracted elevations in levels of fluoride in plaque and saliva. Fluoride incorporated into enamel systemically does not reduce enamel solubility sufficiently to exert an anti-caries effect. Fluoride has the potential to exert an anti-caries benefit largely through three mechanisms; inhibition of demineralisation, promotion of remineralisation and interference with bacterial growth and metabolism. However, the low levels of fluoride thought to influence caries are insufficient to have a significant effect via the latter mechanism. Thus reductions in caries resulting from the use of fluoride toothpastes can be linked to modification of the demineralisation/remineralisation balance by direct effects on dental mineral exerted topically by low levels of fluoride. Numerous in vitro studies have shown that low levels of fluoride, typical of those found after many hours in resting plaque and saliva, and resulting from the regular use of fluoride toothpastes, can have a profound effect on enamel demineralisation and remineralisation.

Predicting the effect of urban noise on the active space of avian vocal signals.

PubMed

Parris, Kirsten M; McCarthy, Michael A

2013-10-01

Urbanization changes the physical environment of nonhuman species but also markedly changes their acoustic environment. Urban noise interferes with acoustic communication in a range of animals, including birds, with potentially profound impacts on fitness. However, a mechanistic theory to predict which species of birds will be most affected by urban noise is lacking. We develop a mathematical model to predict the decrease in the active space of avian vocal signals after moving from quiet forest habitats to noisy urban habitats. We find that the magnitude of the decrease is largely a function of signal frequency. However, this relationship is not monotonic. A metaregression of observed increases in the frequency of birdsong in urban noise supports the model's predictions for signals with frequencies between 1.5 and 4 kHz. Using results of the metaregression and the model described above, we show that the expected gain in active space following observed frequency shifts is up to 12% and greatest for birds with signals at the lower end of this frequency range. Our generally applicable model, along with three predictions regarding the behavioral and population-level responses of birds to urban noise, represents an important step toward a theory of acoustic communication in urban habitats.

Variability in morphology, hygroscopicity, and optical properties of soot aerosols during atmospheric processing

PubMed Central

Zhang, Renyi; Khalizov, Alexei F.; Pagels, Joakim; Zhang, Dan; Xue, Huaxin; McMurry, Peter H.

2008-01-01

The atmospheric effects of soot aerosols include interference with radiative transfer, visibility impairment, and alteration of cloud formation and are highly sensitive to the manner by which soot is internally mixed with other aerosol constituents. We present experimental studies to show that soot particles acquire a large mass fraction of sulfuric acid during atmospheric aging, considerably altering their properties. Soot particles exposed to subsaturated sulfuric acid vapor exhibit a marked change in morphology, characterized by a decreased mobility-based diameter but an increased fractal dimension and effective density. These particles experience large hygroscopic size and mass growth at subsaturated conditions (<90% relative humidity) and act efficiently as cloud-condensation nuclei. Coating with sulfuric acid and subsequent hygroscopic growth enhance the optical properties of soot aerosols, increasing scattering by ≈10-fold and absorption by nearly 2-fold at 80% relative humidity relative to fresh particles. In addition, condensation of sulfuric acid is shown to occur at a similar rate on ambient aerosols of various types of a given mobility size, regardless of their chemical compositions and microphysical structures. Representing an important mechanism of atmospheric aging, internal mixing of soot with sulfuric acid has profound implications on visibility, human health, and direct and indirect climate forcing. PMID:18645179

The management of breakthrough cancer pain--educational needs a European nursing survey.

PubMed

Wengström, Y; Rundström, C; Geerling, J; Pappa, T; Weisse, I; Williams, S C; Zavratnik, B; Rustøen, T

2014-01-01

Poorly managed cancer pain is well known to profoundly impact the patient's daily life and interfere with quality of life. Nurses who cared for patients with cancer from 12 European countries participated in a survey of breakthrough cancer pain practice. The purpose was to investigate how nurses assess breakthrough cancer pain, use of standardised tools, confidence in supporting patients and awareness of medications. Responses from 1241 participants showed country variations. The majority of the sample was female, Germany had the highest proportion of male nurses (21.0%), followed by Greece (15.8%). A significantly larger proportion of nurses with longer experience and more education (78.8%) used a comprehensive definition of breakthrough cancer pain. Significant variations in training were found; 71% of Finnish nurses had received training compared with 6% of Greek nurses. Training and using a standardised assessment tool was associated with a significant increase in the nurses' perceived ability to distinguish between breakthrough and background pain. Nurses in countries with the highest proportion of training were most confident in supporting patients. In conclusion, there still exists problems with effective management of patients' breakthrough cancer pain, continuing inability to define the difference between background and breakthrough cancer pain leads to poor treatment. © 2013 John Wiley & Sons Ltd.

High-Resolution Displacement Sensor Using a SQUID Array Amplifier

NASA Technical Reports Server (NTRS)

Chui, Talso; Penanen, Konstantin; Barmatz, M.; Paik, Ho Jung

2004-01-01

Improvement in the measurement of displacement has profound implications for both exploration technologies and fundamental physics. For planetary exploration, the new SQUID-based capacitive displacement sensor will enable a more sensitive gravity gradiometer for mapping the interior of planets and moons. A new concept of a superfluid clock to be reported by Penanen and Chui at this workshop is also based on a high-resolution displacement sensor. Examples of high-impact physics projects that can benefit from a better displacement sensor are: detection of gravitational waves, test of the equivalence principle, search for the postulated "axion" particle, and test of the inverse square law of gravity. We describe the concept of a new displacement sensor that makes use of a recent development in the Superconducting Quantum Interference Device (SQUID) technology. The SQUID array amplifier, invented by Welty and Martinis (IEEE Trans. Appl. Superconductivity 3, 2605, 1993), has about the same noise as a conventional SQUID; however, it can work at a much higher frequency of up to 5 MHz. We explain how the higher bandwidth can be translated into higher resolution using a bridge-balancing scheme that can simultaneously balance out both the carrier signal at the bridge output and the electrostatic force acting on the test mass.

Policies for accelerating access to clean energy, improving health, advancing development, and mitigating climate change.

PubMed

Haines, Andy; Smith, Kirk R; Anderson, Dennis; Epstein, Paul R; McMichael, Anthony J; Roberts, Ian; Wilkinson, Paul; Woodcock, James; Woods, Jeremy

2007-10-06

The absence of reliable access to clean energy and the services it provides imposes a large disease burden on low-income populations and impedes prospects for development. Furthermore, current patterns of fossil-fuel use cause substantial ill-health from air pollution and occupational hazards. Impending climate change, mainly driven by energy use, now also threatens health. Policies to promote access to non-polluting and sustainable sources of energy have great potential both to improve public health and to mitigate (prevent) climate disruption. There are several technological options, policy levers, and economic instruments for sectors such as power generation, transport, agriculture, and the built environment. However, barriers to change include vested interests, political inertia, inability to take meaningful action, profound global inequalities, weak technology-transfer mechanisms, and knowledge gaps that must be addressed to transform global markets. The need for policies that prevent dangerous anthropogenic interference with the climate while addressing the energy needs of disadvantaged people is a central challenge of the current era. A comprehensive programme for clean energy should optimise mitigation and, simultaneously, adaption to climate change while maximising co-benefits for health--eg, through improved air, water, and food quality. Intersectoral research and concerted action, both nationally and internationally, will be required.

A simulation study of the equatorial ionospheric response to the October 2013 geomagnetic storm

NASA Astrophysics Data System (ADS)

Lei, J.; Ren, D.

2017-12-01

The ionospheric observation from ionosonde at Sao Luis (2.5S, 44.2W; 7S dip latitude) around the magnetic equator showed that the nighttime ionospheric F2 peak height (hmF2) was uplifted by more than 150 km during the October 2013 geomagnetic storm. The changes of hmF2 at the magnetic equator were generally attributed to the variations of vertical drift associated with zonal electric field. In this paper, the Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM) simulation results are utilized to explore the possible physical mechanisms responsible for the observed increase of hmF2 at Sao Luis. The TIEGCM reproduced the changes of F2 peak electron density (NmF2) and its height (hmF2) during the main and recovery phases of the October 2013 storm. A series of controlled simulations revealed that, besides the enhancement of vertical plasma drift, the convergence of horizontal neutral winds and thermospheric expansion also contributed significantly to the profound increase of nighttime hmF2 observed at Sao Luis on 2 October. Moreover, the changes of neutral winds and neutral temperature in the equatorial region are associated with the interference of storm time travelling atmospheric disturbances originating from high latitudes.

A Comprehensive Model for Real Gas Transport in Shale Formations with Complex Non-planar Fracture Networks

PubMed Central

Yang, Ruiyue; Huang, Zhongwei; Yu, Wei; Li, Gensheng; Ren, Wenxi; Zuo, Lihua; Tan, Xiaosi; Sepehrnoori, Kamy; Tian, Shouceng; Sheng, Mao

2016-01-01

A complex fracture network is generally generated during the hydraulic fracturing treatment in shale gas reservoirs. Numerous efforts have been made to model the flow behavior of such fracture networks. However, it is still challenging to predict the impacts of various gas transport mechanisms on well performance with arbitrary fracture geometry in a computationally efficient manner. We develop a robust and comprehensive model for real gas transport in shales with complex non-planar fracture network. Contributions of gas transport mechanisms and fracture complexity to well productivity and rate transient behavior are systematically analyzed. The major findings are: simple planar fracture can overestimate gas production than non-planar fracture due to less fracture interference. A “hump” that occurs in the transition period and formation linear flow with a slope less than 1/2 can infer the appearance of natural fractures. The sharpness of the “hump” can indicate the complexity and irregularity of the fracture networks. Gas flow mechanisms can extend the transition flow period. The gas desorption could make the “hump” more profound. The Knudsen diffusion and slippage effect play a dominant role in the later production time. Maximizing the fracture complexity through generating large connected networks is an effective way to increase shale gas production. PMID:27819349

A Comprehensive Model for Real Gas Transport in Shale Formations with Complex Non-planar Fracture Networks.

PubMed

Yang, Ruiyue; Huang, Zhongwei; Yu, Wei; Li, Gensheng; Ren, Wenxi; Zuo, Lihua; Tan, Xiaosi; Sepehrnoori, Kamy; Tian, Shouceng; Sheng, Mao

2016-11-07

A complex fracture network is generally generated during the hydraulic fracturing treatment in shale gas reservoirs. Numerous efforts have been made to model the flow behavior of such fracture networks. However, it is still challenging to predict the impacts of various gas transport mechanisms on well performance with arbitrary fracture geometry in a computationally efficient manner. We develop a robust and comprehensive model for real gas transport in shales with complex non-planar fracture network. Contributions of gas transport mechanisms and fracture complexity to well productivity and rate transient behavior are systematically analyzed. The major findings are: simple planar fracture can overestimate gas production than non-planar fracture due to less fracture interference. A "hump" that occurs in the transition period and formation linear flow with a slope less than 1/2 can infer the appearance of natural fractures. The sharpness of the "hump" can indicate the complexity and irregularity of the fracture networks. Gas flow mechanisms can extend the transition flow period. The gas desorption could make the "hump" more profound. The Knudsen diffusion and slippage effect play a dominant role in the later production time. Maximizing the fracture complexity through generating large connected networks is an effective way to increase shale gas production.

Human dignity and the profoundly disabled: a theological perspective.

PubMed

Matthews, Pia

2011-01-01

One challenge to the concept of human dignity is that it is a rootless notion invoked simply to mask inequalities that inevitably exist between human beings. This privileging of humans is speciesist and its weak point is the profoundly disabled human being. This article argues that far from being a weak point, the profoundly disabled person is a source of strength and witness to the intrinsic dignity that all human beings have by virtue of being human. The disabled represent the reality of human existence that is both strong and fragile. Although human dignity can be understood philosophically its depth is rooted in Christian theological insights. The profoundly disabled occupy a privileged position and share in a theology of mission since they testify to the interdependence of every human being and human dependence on God to a myopic world that only values strength, autonomy and independence.

Connections that Count: Brain-Computer Interface Enables the Profoundly Paralyzed to Communicate

MedlinePlus

... Home Current Issue Past Issues Connections that Count: Brain-Computer Interface Enables the Profoundly Paralyzed to Communicate ... of this page please turn Javascript on. A brain-computer interface (BCI) system This brain-computer interface ( ...

Characteristics of an Appropriate Education for Severely and Profoundly Handicapped Students.

ERIC Educational Resources Information Center

Bates, Paul; And Others

1981-01-01

Twelve characteristics are important for an appropriate program for severely/profoundly handicapped (SPH) individuals: age appropriate curriculum, specific objectives, functional activities, consistent cue hierarchy, regular data collection, periodic individualized educational program revision, detailed classroom schedule, instruction outside the…

Relationship of Piaget's sensorimotor period to language acquisition of profoundly retarded children.

PubMed

Kahn, J V

1975-05-01

The relationship of Stage 6 of Piaget's sensorimotor period and the acquisition of meaningful expressive language was investigated. The sample consisted of eight profoundly retarded children who exhibited some meaningful expressive language and eight profoundly retarded children who exhibited none. Chronological ages of the children ranged from 47 to 98 months. A strong relationship was found between meaningful expressive language and Stage 6 functioning as tested by the Uzgiris and Hunt (Note 1) instrument. The findings were discussed in terms of supporting Piaget's theory that cognitive structures exist which are prerequisites for the development of language.

Delayed dyskinesia and prolonged psychosis in a patient presenting with profound hyponatraemia.

PubMed

John, Victoria; Evans, Philip; Kalhan, Atul

2017-01-01

A 65-year-old woman was admitted to the emergency unit with a 48 h history of generalised weakness and confusion. On examination, she had mild slurring of speech although there was no other focal neurological deficit. She had profound hyponatraemia (serum sodium level of 100 mmol/L) on admission with the rest of her metabolic parameters being within normal range. Subsequent investigations confirmed the diagnosis of small-cell lung cancer with paraneoplastic syndrome of inappropriate antidiuresis (SIAD). She was monitored closely in high-dependency unit with an attempt to cautiously correct her hyponatraemia to prevent sequelae associated with rapid correction. The patient developed prolonged psychosis (lasting over 2 weeks) and displayed delayed dyskinetic movements, even after a gradual increase in serum sodium levels close to 130 mmol/L. To our knowledge, delayed neurological recovery from profound hyponatraemia (without long-term neurological sequelae) has previously not been reported. This case should alert a clinician regarding the possibility of prolonged although reversible psychosis and dyskinetic movements in a patient presenting with profound symptomatic hyponatraemia. Patients with profound hyponatraemia may develop altered sensorium, dyskinesia and psychotic behaviour.Full recovery from psychotic symptoms and dyskinesia may be delayed despite cautious correction of serum sodium levels.Careful and close monitoring of such patients can help avoid long-term neurological sequelae.

Synchronicity and the meaning-making psyche.

PubMed

Colman, Warren

2011-09-01

This paper contrasts Jung's account of synchronicity as evidence of an objective principle of meaning in Nature with a view that emphasizes human meaning-making. All synchronicities generate indicative signs but only where this becomes a 'living symbol' of a transcendent intentionality at work in a living universe does synchronicity generate the kind of symbolic meaning that led Jung to posit the existence of a Universal Mind. This is regarded as a form of personal, experiential knowledge belonging to the 'imaginal world of meaning' characteristic of the 'primordial mind', as opposed to the 'rational world of knowledge' in which Jung attempted to present his experiences as if they were empirically and publicly verifiable. Whereas rational knowledge depends on a form of meaning in which causal chains and logical links are paramount, imaginal meaning is generated by forms of congruent correspondence-a feature that synchronicity shares with metaphor and symbol-and the creation of narratives by means of retroactive organization of its constituent elements. © 2011, The Society of Analytical Psychology.

Use of the Moon for spacecraft calibration over 350-2500 nm

USGS Publications Warehouse

Kieffer, H.H.; Anderson, J.M.

1998-01-01

The Moon is the only natural object outside the Earth's atmosphere that is within the dynamic range of most imaging instruments on Earth-orbiting spacecraft. The excellent photometric stability of the Lunar surface will allow its use as a long-term instrument calibration source once the dependence of Lunar spectral radiance on phase and libration angles are well characterized. A program to provide this characterization is underway. Observations are being made in 23 bands within 350-950 nm, 7 of which correspond closely with spacecraft instrument bands. Observations in nine bands within 950-2500 nm began recently. Although at this time the absolute Lunar radiance model is preliminary and uncertainties are larger than most instrument calibration goals, changes in spacecraft instrument sensitivity can be precisely monitored and absolute calibration can be applied retroactively as the accuracy of the Lunar spectral radiance model improves. Several space-based imaging systems have already begun using the Moon for calibration and the EOS AM-1 platform will make periodic attitude maneuvers for Lunar and space calibration.

Toward global mapping of river discharge using satellite images and at-many-stations hydraulic geometry

PubMed Central

Gleason, Colin J.; Smith, Laurence C.

2014-01-01

Rivers provide critical water supply for many human societies and ecosystems, yet global knowledge of their flow rates is poor. We show that useful estimates of absolute river discharge (in cubic meters per second) may be derived solely from satellite images, with no ground-based or a priori information whatsoever. The approach works owing to discovery of a characteristic scaling law uniquely fundamental to natural rivers, here termed a river’s at-many-stations hydraulic geometry. A first demonstration using Landsat Thematic Mapper images over three rivers in the United States, Canada, and China yields absolute discharges agreeing to within 20–30% of traditional in situ gauging station measurements and good tracking of flow changes over time. Within such accuracies, the door appears open for quantifying river resources globally with repeat imaging, both retroactively and henceforth into the future, with strong implications for water resource management, food security, ecosystem studies, flood forecasting, and geopolitics. PMID:24639551

Thinking on your feet: understanding the immediate responses of staff to adults who challenge intellectual disability services.

PubMed

Ravoux, Peggy; Baker, Peter; Brown, Hilary

2012-05-01

A gap prevails between the conceptualization of good practice in challenging behaviour management and its implementation in intellectual disability services. This study aimed to investigate staff members' perspectives of managing clients with challenging behaviours in residential services. Semi-structured interviews were conducted with eleven staff in two services. Additionally, service documents on challenging behaviour management were examined in these services. A qualitative methodology was used to investigate staff members' immediate responses to clients' difficult behaviours and their decision-making processes. The immediate responses of staff were conceptualized as the result of complex appraisals shaped by their service context involving the core processes of making the right choice and prioritizing the best interests of all involved. Staff members' responses were understood as a dynamic and retroactive process, where their past and current challenging behaviour management experiences in the service influenced their responses to clients in the future. © 2011 Blackwell Publishing Ltd.

Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against 'morning sickness'.

PubMed

Westfall, Rachel E; Janssen, Patricia A; Lucas, Philippe; Capler, Rielle

2006-02-01

A majority of women experience some nausea and/or vomiting during pregnancy. This condition can range from mild nausea to extreme nausea and vomiting, with 1-2% of women suffering from the life-threatening condition hyperemesis gravidarum. Cannabis (Cannabis sativa) may be used therapeutically to mitigate pregnancy-induced nausea and vomiting. This paper presents the results of a survey of 84 female users of medicinal cannabis, recruited through two compassion societies in British Columbia, Canada. Of the seventy-nine respondents who had experienced pregnancy, 51 (65%) reported using cannabis during their pregnancies. While 59 (77%) of the respondents who had been pregnant had experienced nausea and/or vomiting of pregnancy, 40 (68%) had used cannabis to treat the condition, and of these respondents, 37 (over 92%) rated cannabis as 'extremely effective' or 'effective.' Our findings support the need for further investigations into cannabis therapy for severe nausea and vomiting during pregnancy.

Quantum information theory of the Bell-state quantum eraser

NASA Astrophysics Data System (ADS)

Glick, Jennifer R.; Adami, Christoph

2017-01-01

Quantum systems can display particle- or wavelike properties, depending on the type of measurement that is performed on them. The Bell-state quantum eraser is an experiment that brings the duality to the forefront, as a single measurement can retroactively be made to measure particlelike or wavelike properties (or anything in between). Here we develop a unitary information-theoretic description of this and several related quantum measurement situations that sheds light on the trade-off between the quantum and classical features of the measurement. In particular, we show that both the coherence of the quantum state and the classical information obtained from it can be described using only quantum-information-theoretic tools and that those two measures satisfy an equality on account of the chain rule for entropies. The coherence information and the which-path information have simple interpretations in terms of state preparation and state determination and suggest ways to account for the relationship between the classical and the quantum world.

Chromosomes on the move: The educational and neurological advantages of using body movement to teach cellular division

NASA Astrophysics Data System (ADS)

Baumwoll, Alma Aron

As education and neuroscience begin to merge, creating the new field of brain-based education, teachers are working to integrate scientific research into the classroom. While working to improve my own teaching, I developed a lesson plan to teach mitosis and meiosis through movement. My thesis reviews education theory and neuroscience to support using movement as a teaching tool in high-level, subject-based classrooms. I then outline my lesson plan and present my investigations of its effectiveness as demonstrated through short-term memory, long-term memory, and students' personal responses to the class. Two experiments were completed with biology lab sections at Northeastern University between 2009 and 2012; I taught my lesson to experimental groups while control groups learned through video-based lessons. The short-term study showed significant improvement in both the grades and enjoyment of the experimental groups. The long-term, retroactive study yielded no significant data, possibly due to weaknesses in the experimental design.

Toward global mapping of river discharge using satellite images and at-many-stations hydraulic geometry.

PubMed

Gleason, Colin J; Smith, Laurence C

2014-04-01

Rivers provide critical water supply for many human societies and ecosystems, yet global knowledge of their flow rates is poor. We show that useful estimates of absolute river discharge (in cubic meters per second) may be derived solely from satellite images, with no ground-based or a priori information whatsoever. The approach works owing to discovery of a characteristic scaling law uniquely fundamental to natural rivers, here termed a river's at-many-stations hydraulic geometry. A first demonstration using Landsat Thematic Mapper images over three rivers in the United States, Canada, and China yields absolute discharges agreeing to within 20-30% of traditional in situ gauging station measurements and good tracking of flow changes over time. Within such accuracies, the door appears open for quantifying river resources globally with repeat imaging, both retroactively and henceforth into the future, with strong implications for water resource management, food security, ecosystem studies, flood forecasting, and geopolitics.

Main control computer security model of closed network systems protection against cyber attacks

NASA Astrophysics Data System (ADS)

Seymen, Bilal

2014-06-01

The model that brings the data input/output under control in closed network systems, that maintains the system securely, and that controls the flow of information through the Main Control Computer which also brings the network traffic under control against cyber-attacks. The network, which can be controlled single-handedly thanks to the system designed to enable the network users to make data entry into the system or to extract data from the system securely, intends to minimize the security gaps. Moreover, data input/output record can be kept by means of the user account assigned for each user, and it is also possible to carry out retroactive tracking, if requested. Because the measures that need to be taken for each computer on the network regarding cyber security, do require high cost; it has been intended to provide a cost-effective working environment with this model, only if the Main Control Computer has the updated hardware.

Similarities and differences of emotions in human-machine and human-human interactions: what kind of emotions are relevant for future companion systems?

PubMed

Walter, Steffen; Wendt, Cornelia; Böhnke, Jan; Crawcour, Stephen; Tan, Jun-Wen; Chan, Andre; Limbrecht, Kerstin; Gruss, Sascha; Traue, Harald C

2014-01-01

Cognitive-technical intelligence is envisioned to be constantly available and capable of adapting to the user's emotions. However, the question is: what specific emotions should be reliably recognised by intelligent systems? Hence, in this study, we have attempted to identify similarities and differences of emotions between human-human (HHI) and human-machine interactions (HMI). We focused on what emotions in the experienced scenarios of HMI are retroactively reflected as compared with HHI. The sample consisted of N = 145 participants, who were divided into two groups. Positive and negative scenario descriptions of HMI and HHI were given by the first and second groups, respectively. Subsequently, the participants evaluated their respective scenarios with the help of 94 adjectives relating to emotions. The correlations between the occurrences of emotions in the HMI versus HHI were very high. The results do not support the statement that only a few emotions in HMI are relevant.

Customization of Advia 120 thresholds for canine erythrocyte volume and hemoglobin concentration, and effects on morphology flagging results.

PubMed

Grimes, Carolyn N; Fry, Michael M

2014-12-01

This study sought to develop customized morphology flagging thresholds for canine erythrocyte volume and hemoglobin concentration [Hgb] on the ADVIA 120 hematology analyzer; compare automated morphology flagging with results of microscopic blood smear evaluation; and examine effects of customized thresholds on morphology flagging results. Customized thresholds were determined using data from 52 clinically healthy dogs. Blood smear evaluation and automated morphology flagging results were correlated with mean cell volume (MCV) and cellular hemoglobin concentration mean (CHCM) in 26 dogs. Customized thresholds were applied retroactively to complete blood (cell) count (CBC) data from 5 groups of dogs, including a reference sample group, clinical cases, and animals with experimentally induced iron deficiency anemia. Automated morphology flagging correlated more highly with MCV or CHCM than did blood smear evaluation; correlation with MCV was highest using customized thresholds. Customized morphology flagging thresholds resulted in more sensitive detection of microcytosis, macrocytosis, and hypochromasia than default thresholds.

Four types of interference competition and their impacts on the ecology and evolution of size-structured populations and communities.

PubMed

Zhang, Lai; Andersen, Ken H; Dieckmann, Ulf; Brännström, Åke

2015-09-07

We investigate how four types of interference competition - which alternatively affect foraging, metabolism, survival, and reproduction - impact the ecology and evolution of size-structured populations. Even though all four types of interference competition reduce population biomass, interference competition at intermediate intensity sometimes significantly increases the abundance of adult individuals and the population׳s reproduction rate. We find that foraging and metabolic interference evolutionarily favor smaller maturation size when interference is weak and larger maturation size when interference is strong. The evolutionary response to survival interference and reproductive interference is always larger maturation size. We also investigate how the four types of interference competition impact the evolutionary dynamics and resultant diversity and trophic structure of size-structured communities. Like other types of trait-mediated competition, all four types of interference competition can induce disruptive selection and thus promote initial diversification. Even though foraging interference and reproductive interference are more potent in promoting initial diversification, they catalyze the formation of diverse communities with complex trophic structure only at high levels of interference intensity. By contrast, survival interference does so already at intermediate levels, while reproductive interference can only support relatively smaller communities with simpler trophic structure. Taken together, our results show how the type and intensity of interference competition jointly affect coexistence patterns in structured population models. Copyright © 2015 Elsevier Ltd. All rights reserved.

Let's Get Fit!: Fitness Activities for Children with Severe/Profound Disabilities.

ERIC Educational Resources Information Center

Modell, Scott J.; Cox, Thomas Alan

1999-01-01

Guidelines for developing a physical activity program for students with severe/profound disabilities address medical clearance; levels of participation; staffing; equipment; and program components, including warm-up, range of motion/flexibility activities, aerobics, resistance training, and cool-down. (DB)

22 CFR 95.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... administration or application, of mind altering substances or other procedures calculated to disrupt profoundly... application of mind altering substances or other procedures calculated to disrupt profoundly the senses or... custody or physical control. (5) The term “acquiescence” as used in this definition requires that the...

An Annotated Bibliography on the Severely and Profoundly Mentally Retarded.

ERIC Educational Resources Information Center

Cass, Michael, Comp.; Schilit, Jeffrey, Comp.

Presented is an annotated bibliography with approximately 250 entries relating to the severely and profoundly retarded. Citations are listed alphabetically by author under the following categories: assessments, measurements, evaluations; associations; attending behavior; behavior modification; books; classical conditioning; cognitive development;…

Does Aggressive Phototherapy Increase Mortality while Decreasing Profound Impairment among the Smallest and Sickest Newborns?

PubMed Central

Tyson, Jon E; Pedroza, Claudia; Langer, John; Green, Charles; Morris, Brenda; Stevenson, David; Van Meurs, Krisa P.; Oh, William; Phelps, Dale; O’Shea, Michael; McDavid, Georgia E.; Grisby, Cathy; Higgins, Rose

2013-01-01

Objective Aggressive phototherapy (AgPT) is widely used and assumed to be safe and effective for even the most immature infants. We assessed whether the benefits and hazards for the smallest and sickest infants differed from those for other extremely low birth weight (ELBW; (≤1000 g) infants in our Neonatal Research Network trial, the only large trial of AgPT. Study Design ELBW infants (n=1974) were randomized to AgPT or conservative phototherapy at age 12–36 hours. The effect of AgPT on outcomes (death; impairment; profound impairment; death or impairment [primary outcome], and death or profound impairment) at 18–22 months corrected age was related to BW stratum (501–750 g; 751–1000 g) and baseline severity of illness using multilevel regression equations. The probability of benefit and of harm was directly assessed with Bayesian analyses. Results Baseline illness severity was well characterized using mechanical ventilation and FiO2 at 24 hours age. Among mechanically ventilated infants ≤750 g BW (n =684), a reduction in impairment and in profound impairment was offset by higher mortality (p for interaction <0.05) with no significant effect on composite outcomes. Conservative Bayesian analyses of this subgroup identified a 99% (posterior) probability that AgPT increased mortality, a 97% probability that AgPT reduced impairment, and a 99% probability that AgPT reduced profound impairment. Conclusions Findings from the only large trial of AgPT suggest that AgPT may increase mortality while reducing impairment and profound impairment among the smallest and sickest infants. New approaches to reduce their serum bilirubin need development and rigorous testing. PMID:22652561

Neural mechanisms of interference control in working memory: effects of interference expectancy and fluid intelligence.

PubMed

Burgess, Gregory C; Braver, Todd S

2010-09-20

A critical aspect of executive control is the ability to limit the adverse effects of interference. Previous studies have shown activation of left ventrolateral prefrontal cortex after the onset of interference, suggesting that interference may be resolved in a reactive manner. However, we suggest that interference control may also operate in a proactive manner to prevent effects of interference. The current study investigated the temporal dynamics of interference control by varying two factors - interference expectancy and fluid intelligence (gF) - that could influence whether interference control operates proactively versus reactively. A modified version of the recent negatives task was utilized. Interference expectancy was manipulated across task blocks by changing the proportion of recent negative (interference) trials versus recent positive (facilitation) trials. Furthermore, we explored whether gF affected the tendency to utilize specific interference control mechanisms. When interference expectancy was low, activity in lateral prefrontal cortex replicated prior results showing a reactive control pattern (i.e., interference-sensitivity during probe period). In contrast, when interference expectancy was high, bilateral prefrontal cortex activation was more indicative of proactive control mechanisms (interference-related effects prior to the probe period). Additional results suggested that the proactive control pattern was more evident in high gF individuals, whereas the reactive control pattern was more evident in low gF individuals. The results suggest the presence of two neural mechanisms of interference control, with the differential expression of these mechanisms modulated by both experimental (e.g., expectancy effects) and individual difference (e.g., gF) factors.

An atypical case of successful resuscitation of an accidental profound hypothermia patient, occurring in a temperate climate.

PubMed

Coleman, E; Doddakula, K; Meeke, R; Marshall, C; Jahangir, S; Hinchion, J

2010-03-01

Cases of accidental profound hypothermia occur most frequently in cold, northern climates. We describe an atypical case, occurring in a temperate climate, where a hypothermic cardiac-arrested patient was successfully resuscitated using extracorporeal circulation (ECC).

The Spiritual Disciplines as Practices of Transformation

ERIC Educational Resources Information Center

Carr-Chellman, Davin J.; Kroth, Michael

2017-01-01

Spiritual disciplines are practices of transformation intentionally pursued through the day-to-day actions of deeper living. The spiritual disciplines are conceptualized here in their relationship to profound learning. The authors contend that profound learners exhibit certain dispositions, such as curiosity, that facilitate continual growth.…

Intellectual Prosthesis: Reality or Dream for the Severely/Profoundly Retarded Person.

ERIC Educational Resources Information Center

Lent, James R.

1982-01-01

Developments in artificial intelligence have relevance for the education of severely/profoundly retarded persons by enhancing the learning of facts, principles, skills and concepts and by providing opportunities (via more portable equipment) for applications in a wide variety of settings. (CL)

Attuning: A Communication Process between People with Severe and Profound Intellectual Disability and Their Interaction Partners.

PubMed

Griffiths, Colin; Smith, Martine

2016-03-01

People with severe and profound intellectual disability typically demonstrate a limited ability to communicate effectively. Most of their communications are non-verbal, often idiosyncratic and ambiguous. This article aims to identify the process that regulates communications of this group of people with others and to describe the methodological approach that was used to achieve this. In this qualitative study, two dyads consisting of a person with severe or profound intellectual and multiple disability and a teacher or carer were filmed as they engaged in school-based activities. Two 1-hour videotapes were transcribed and analysed using grounded theory. Attuning was identified within the theory proposed here as a central process that calibrates and regulates communication. Attuning is conceptualized as a bidirectional, dyadic communication process. Understanding this process may support more effective communication between people with severe or profound intellectual and multiple disability and their interaction partners. © 2015 John Wiley & Sons Ltd.

Various Strategies for Pain-Free Root Canal Treatment

PubMed Central

Parirokh, Masoud; V. Abbott, Paul

2014-01-01

Introduction: Achieving successful anesthesia and performing pain-free root canal treatment are important aims in dentistry. This is not always achievable and therefore, practitioners are constantly seeking newer techniques, equipments, and anesthetic solutions for this very purpose. The aim of this review is to introduce strategies to achieve profound anesthesia particularly in difficult cases. Materials and Methods: A review of the literature was performed by electronic and hand searching methods for anesthetic agents, techniques, and equipment. The highest level of evidence based investigations with rigorous methods and materials were selected for discussion. Results: Numerous studies investigated to pain management during root canal treatment; however, there is still no single technique that will predictably provide profound pulp anesthesia. One of the most challenging issues in endodontic practice is achieving a profound anesthesia for teeth with irreversible pulpitis especially in mandibular posterior region. Conclusion: According to most investigations, achieving a successful anesthesia is not always possible with a single technique and practitioners should be aware of all possible alternatives for profound anesthesia. PMID:24396370

Foveal Processing Under Concurrent Peripheral Load in Profoundly Deaf Adults

PubMed Central

2016-01-01

Development of the visual system typically proceeds in concert with the development of audition. One result is that the visual system of profoundly deaf individuals differs from that of those with typical auditory systems. While past research has suggested deaf people have enhanced attention in the visual periphery, it is still unclear whether or not this enhancement entails deficits in central vision. Profoundly deaf and typically hearing adults were administered a variant of the useful field of view task that independently assessed performance on concurrent central and peripheral tasks. Identification of a foveated target was impaired by a concurrent selective peripheral attention task, more so in profoundly deaf adults than in the typically hearing. Previous findings of enhanced performance on the peripheral task were not replicated. These data are discussed in terms of flexible allocation of spatial attention targeted towards perceived task demands, and support a modified “division of labor” hypothesis whereby attentional resources co-opted to process peripheral space result in reduced resources in the central visual field. PMID:26657078

Interference competition and invasion: spatial structure, novel weapons and resistance zones.

PubMed

Allstadt, Andrew; Caraco, Thomas; Molnár, F; Korniss, G

2012-08-07

Certain invasive plants may rely on interference mechanisms (e.g., allelopathy) to gain competitive superiority over native species. But expending resources on interference presumably exacts a cost in another life-history trait, so that the significance of interference competition for invasion ecology remains uncertain. We model ecological invasion when combined effects of preemptive and interference competition govern interactions at the neighborhood scale. We consider three cases. Under "novel weapons," only the initially rare invader exercises interference. For "resistance zones" only the resident species interferes, and finally we take both species as interference competitors. Interference increases the other species' mortality, opening space for colonization. However, a species exercising greater interference has reduced propagation, which can hinder its colonization of open sites. Interference never enhances a rare invader's growth in the homogeneously mixing approximation to our model. But interference can significantly increase an invader's competitiveness, and its growth when rare, if interactions are structured spatially. That is, interference can increase an invader's success when colonization of open sites depends on local, rather than global, species densities. In contrast, interference enhances the common, resident species' resistance to invasion independently of spatial structure, unless the propagation-cost is too great. The particular combination of propagation and interference producing the strongest biotic resistance in a resident species depends on the shape of the tradeoff between the two traits. Increases in background mortality (i.e., mortality not due to interference) always reduce the effectiveness of interference competition. Copyright © 2012 Elsevier Ltd. All rights reserved.

Research for the jamming mechanism of high-frequency laser to the laser seeker

NASA Astrophysics Data System (ADS)

Zheng, Xingyuan; Zhang, Haiyang; Wang, Yunping; Feng, Shuang; Zhao, Changming

2013-08-01

High-frequency laser will be able to enter the enemy laser signal processing systems without encoded identification and a copy. That makes it one of the research directions of new interference sources. In order to study the interference mechanism of high-frequency laser to laser guided weapons. According to the principle of high-frequency laser interference, a series of related theoretical models such as a semi-active laser seeker coded identification model, a time door model, multi-signal processing model and a interference signal modulation processing model are established. Then seeker interfere with effective 3σ criterion is proposed. Based on this, the study of the effect of multi-source interference and signal characteristics of the effect of high repetition frequency laser interference are key research. According to the simulation system testing, the results show that the multi-source interference and interference signal frequency modulation can effectively enhance the interference effect. While the interference effect of the interference signal amplitude modulation is not obvious. The research results will provide the evaluation of high-frequency laser interference effect and provide theoretical references for high-frequency laser interference system application.

Knickkopf and retroactive proteins are required for formation of laminar serosal procuticle during embryonic development of Tribolium castaneum.

PubMed

Chaudhari, Sujata S; Noh, Mi Young; Moussian, Bernard; Specht, Charles A; Kramer, Karl J; Beeman, Richard W; Arakane, Yasuyuki; Muthukrishnan, Subbaratnam

2015-05-01

Chitin, a homopolymer of β-1-4-linked N-acetylglucosamine synthesized by chitin synthase A (Chs-A), is organized in the procuticle of the postembryonic cuticle or exoskeleton, which is composed of laminae stacked parallel to the cell surface to give stability and integrity to the underlying insect epidermal and other tissues. Our previous work has revealed an important role for two proteins from Tribolium castaneum named Knickkopf (TcKnk) and Retroactive (TcRtv) in postembryonic cuticular chitin maintenance. TcKnk and TcRtv were shown to be required for protection and organization of newly synthesized procuticular chitin. To study the functions of TcKnk and TcRtv in serosal and larval cuticles produced during embryogenesis in T. castaneum, dsRNAs specific for these two genes were injected into two week-old adult females. The effects of dsRNA treatment on ovarial integrity, oviposition, egg hatching and adult survival were determined. Insects treated with dsRNA for chitin synthase-A (TcChs-A) and tryptophan oxygenase (TcVer) were used as positive and negative controls for these experiments, respectively. Like TcChs-A RNAi, injection of dsRNA for TcKnk or TcRtv into adult females exhibited no adult lethality and oviposition was normal. However, a vast majority of the embryos did not hatch. The remaining (∼10%) of the embryos hatched into first instar larvae that died without molting to the second instar. Chitin content analysis following TcKnk and TcRtv parental RNAi revealed approximately 50% reduction in chitin content of eggs in comparison with control TcVer RNAi, whereas TcChs-A dsRNA-treatment led to >90% loss of chitin. Furthermore, transmission electron microscopic (TEM) analysis of serosal cuticle from TcChs-A, TcKnk and TcRtv dsRNA-treated insects revealed a complete absence of laminar organization of serosal (and larval) procuticle in comparison with TcVer dsRNA-treated controls, which exhibited normal laminar organization of procuticular chitin. The results of this study demonstrate that in addition to their essential roles in maintenance and organization of chitin in epidermal cuticle in larval and later stages of insect development, TcKnk and TcRtv also are required for egg hatch, chitin maintenance and laminar organization of both serosal and larval cuticle during embryonic development of T. castaneum. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Prevalence of Boredom Proneness and Depression among Profoundly Deaf Residential School Adolescents.

ERIC Educational Resources Information Center

Watt, John D.; Davis, Faith E.

1991-01-01

Fifty profoundly deaf residential school adolescents were administered the Boredom Proneness scale and a modified version of the Beck Depression Inventory. Deaf students had a significantly higher incidence of depression and were more boredom prone than were hearing subjects. (Author/JDD)

Foundation Care: A Treatment Model for Nonambulatory Profoundly Mentally Retarded Persons.

ERIC Educational Resources Information Center

LaMendola, Walter F.; And Others

1987-01-01

Two institutional treatment models--Intermediate Care Facilities and Foundation Care--were compared with 30 profoundly mentally retarded adults. The Foundation Care model (which emphasized habilitation through health, nurturance, stimulation, and play) demonstrated more resident-oriented management practices and used more tactile modalities and…

Training Eye-Pointing Behavior in a Nonabulatory Profoundly Mentally Retarded Child Using Contingent Vibratory Stimulation.

ERIC Educational Resources Information Center

Zucker, Stanley H.; And Others

1980-01-01

Contingent vibration was used to train a precommunication response in a spastic/quadriplegic profoundly mentally retarded boy (age 11). The results indicated an increase in the S's eye pointing behavior subsequent to the administration of response contingent vibration. (Author)

Specific needs of families of young adults with profound intellectual disability during and after transition to adulthood: What are we missing?

PubMed

Gauthier-Boudreault, Camille; Gallagher, Frances; Couture, Mélanie

2017-07-01

At the age of 21, the trajectory of services offered to youth with profound intellectual disability (ID) change significantly since access to specialised services is more limited. Despite the desire of parents to avoid any impact on their child, several factors can influence the course of this transition. However, there is little research on facilitators and obstacles to the transition to adulthood, and impacts on people with a profound ID. It is therefore difficult to provide solutions that meet their specific needs. The study aimed to document the needs of parents and young adults with profound ID during and after the transition to adulthood by exploring their transitioning experience and factors that influenced it. Using a descriptive qualitative design, two individual semi-structured interviews were conducted with fourteen (14) parents of young adults aged between 18 and 26 with a profound ID. At this point, many material, informative, cognitive and emotional needs of young adults and their parents are not met. Obstacles, mainly organisational, persist and result in a particularly difficult transition to adulthood experience. By knowing the specific needs of these families, it is possible to develop and implement solutions tailored to their reality. WHAT THE PAPERS ADDS?: The transition to adulthood is a critical period for families with young adults with an intellectual disability (ID), a reality observed internationally. Current literature on all levels of ID suggests some barriers to transition that lead to negative impacts on both parents and young adults with ID. However, presently, very little research exists on the reality of families of young adults with profound ID and factors influencing transition to adult life. Most of studies target people with mild to moderate ID. Considering the significant disabilities of people with profound ID, it is possible to imagine that their experience of transition will be even more difficult and they will present specific needs. The lack of understanding of these needs makes it difficult to introduce solutions tailored to their reality. The results of this current study suggest that many needs of young adults with profound ID and their parents are not met despite existent transition planning services. Transition to adulthood seems particularly difficult for these families who face many challenges. Parents in this study proposed different obstacles during transition to adulthood that could be improved for creation of future solutions adapted to their reality. Copyright © 2017. Published by Elsevier Ltd.

Study on Interference Suppression Algorithms for Electronic Noses: A Review

PubMed Central

Liang, Zhifang; Zhang, Ci; Sun, Hao; Liu, Tao

2018-01-01

Electronic noses (e-nose) are composed of an appropriate pattern recognition system and a gas sensor array with a certain degree of specificity and broad spectrum characteristics. The gas sensors have their own shortcomings of being highly sensitive to interferences which has an impact on the detection of target gases. When there are interferences, the performance of the e-nose will deteriorate. Therefore, it is urgent to study interference suppression techniques for e-noses. This paper summarizes the sources of interferences and reviews the advances made in recent years in interference suppression for e-noses. According to the factors which cause interference, interferences can be classified into two types: interference caused by changes of operating conditions and interference caused by hardware failures. The existing suppression methods were summarized and analyzed from these two aspects. Since the interferences of e-noses are uncertain and unstable, it can be found that some nonlinear methods have good effects for interference suppression, such as methods based on transfer learning, adaptive methods, etc. PMID:29649152

Interference Effects in Schizophrenic Short-Term Memory

ERIC Educational Resources Information Center

Bauman, Edward; Kolisnyk, Eugene

1976-01-01

Assesses the effects of input and output interference on schizophrenic recall. Input interference is the interference resulting from the interpolation of items between presentation and recall of the probed item. Output interference is the interference resulting from the interpolation of responses between the presentation and recall of the probed…

Aerobic Fitness for the Severely and Profoundly Mentally Retarded.

ERIC Educational Resources Information Center

Bauer, Dan

1981-01-01

The booklet discusses the aerobic fitness capacities of severely/profoundly retarded students and discusses approaches for improving their fitness. An initial section describes a method for determining the student's present fitness level on the basis of computations of height, weight, blood pressure, resting pulse, and Barach Index and Crampton…

Discovering Indices of Contingency Awareness in Adults with Multiple Profound Disabilities

ERIC Educational Resources Information Center

Saunders, Richard R.; Saunders, Muriel D.; Struve, Brittany; Munce, Abbie L.; Olswang, Lesley B.; Dowden, Patricia A.; Klasner, Estelle R.

2007-01-01

Two studies were conducted to examine parameters of social attention in contingency awareness training using switch activation with individuals who had multiple profound disabilities. Study 1 compared leisure devices and social attention as reinforcing stimuli with 5 individuals. Results indicated the reinforcing qualities of social attention over…

Self-Concept of Severely to Profoundly Hearing-Impaired Children.

ERIC Educational Resources Information Center

Warren, Charlotte; Hasenstab, Suzanne

1986-01-01

A study examined demographic, impairment-related, and parental variables that best predicted self-concept among 49 severely to profoundly hearing-impaired 5- to 11-year-olds. A strong relationship was observed between self-concept and parental indulgence, parental rejection, parental protection, parental discipline, and extent of language…

Identifying Reinforcers for Persons with Profound Handicaps: Staff Opinion versus Systematic Assessment of Preferences.

ERIC Educational Resources Information Center

Green, Carolyn W.; And Others

1988-01-01

A systematic assessment procedure successfully identified stimulus preferences of seven profoundly and multiply handicapped individuals (ages 12-34). Preference rankings based on caregiver opinion did not consistently coincide with these results. Systematically assessed student preferences were a likely, though not certain, source of reinforcing…

The False-Friend Effect in Three Profoundly Deaf Learners of French: Disentangling Morphology, Phonology and Orthography

ERIC Educational Resources Information Center

Janke, Vikki; Kolokonte, Marina

2015-01-01

Three profoundly deaf individuals undertook a low-frequency backward lexical translation task (French/English), where morphological structure was manipulated and orthographic distance between test items was measured. Conditions included monomorphemic items (simplex), polymorphemic items (complex), items whose French morphological structure…

Learners with Profound and Complex Needs in Scotland's Colleges

ERIC Educational Resources Information Center

Her Majesty's Inspectorate of Education, 2009

2009-01-01

The Scottish Further and Higher Education Funding Council's (SFC) Corporate Plan (2009-12) makes clear its commitment to learners with profound and complex needs. Under "Outcome 2 Access, Inclusion and Progression" it states: "we will work with the Scottish Government, colleges and other stakeholders to ensure that appropriate…

Developing Skills in Severely and Profoundly Handicapped Children.

ERIC Educational Resources Information Center

Thomas, M. Angele, Ed.

Included in the publication are 10 articles on developing basic skills in severely and profoundly handicapped children. The first paper focuses on the development of object permanence, a basic cognitive skill, while the second and third review procedures for developing self care skills (toileting and eating). A fourth paper discusses an…

Social Peer Interactions in Persons with Profound Intellectual and Multiple Disabilities: A Literature Review

ERIC Educational Resources Information Center

Nijs, Sara; Maes, Bea

2014-01-01

Social interactions may positively influence developmental and quality of life outcomes. Research in persons with profound intellectual and multiple disabilities (PIMD) mostly investigated interactions with caregivers. This literature review focuses on peer interactions of persons with PIMD. A computerized literature search of three databases was…

An Informal Paper: Teaching the Profoundly Handicapped Child.

ERIC Educational Resources Information Center

Silverrain, Ann

The paper outlines the operative principles for understanding learning and discusses how these principles can help in planning a functional program for a severely or profoundly brain-damaged child. Discussed are: (1) the role of memory in learning; (2) simple associative learning (Pavlovian Conditioning and Operant Conditioning); (3) Piaget's…

Cognitive Development of Severely and Profoundly Mentally Retarded Individuals.

ERIC Educational Resources Information Center

Silverstein, A. B.; And Others

1982-01-01

H. Corman and S. Escalona's scales for object permanence and spatial relationships were readministered to 71 severely and profoundly mentally retarded individuals (mean age 19 years) five years after the last previous administration of the scales. Gains in mean scores were small but statistically significant for both scales. (Author)

Stability of Two Piagetian Scales with Severely and Profoundly Retarded Children.

ERIC Educational Resources Information Center

Silverstein, A. B.; And Others

1981-01-01

Corman and Escalona's scales for Object Permanence and Spatial Relationships were administered to 98 severely and profoundly retarded children on three occasions, with intervals of six months between successive administrations. The findings demonstrated the high stability of the scales when environmental conditions are themselves highly stable.…

Pre-Language Activities for the Profoundly Mentally Retarded.

ERIC Educational Resources Information Center

Poole, Marilyn R.; And Others

Provided are sample lesson plans for a program to develop pre-language skills in profoundly retarded children and adults. Characteristic of the suggested activities is the stimulation of all sensory channels through structured infant-like play activities in five general areas: oral stimulation, sensory arousal, motor stimulation, vocal play, and…

A Clinical Application of Applied Humanism for Young Adults with Severe and Profound Retardation.

ERIC Educational Resources Information Center

Mazzelli, AnnaMaria; Polirstok, Susan Rovet; Dana, Lawrence; Buono, Serafina; Mongelli, Vita; Trubia, Grazia; Ayala, Giovanni

2000-01-01

Describes an intensive habilitation program in Sicily for young adults with severe and profound retardation. Participants in the program showed significant improvement in functional skills and an accompanying reduction in maladaptive and stereotypic behaviors, without complex behavior plans; punishing contingencies; or high dose neuroleptic,…

Ventromedial Prefrontal Cortex Is Necessary for Normal Associative Inference and Memory Integration.

PubMed

Spalding, Kelsey N; Schlichting, Margaret L; Zeithamova, Dagmar; Preston, Alison R; Tranel, Daniel; Duff, Melissa C; Warren, David E

2018-04-11

The ability to flexibly combine existing knowledge in response to novel circumstances is highly adaptive. However, the neural correlates of flexible associative inference are not well characterized. Laboratory tests of associative inference have measured memory for overlapping pairs of studied items (e.g., AB, BC) and for nonstudied pairs with common associates (i.e., AC). Findings from functional neuroimaging and neuropsychology suggest the ventromedial prefrontal cortex (vmPFC) may be necessary for associative inference. Here, we used a neuropsychological approach to test the necessity of vmPFC for successful memory-guided associative inference in humans using an overlapping pairs associative memory task. We predicted that individuals with focal vmPFC damage ( n = 5; 3F, 2M) would show impaired inferential memory but intact non-inferential memory. Performance was compared with normal comparison participants ( n = 10; 6F, 4M). Participants studied pairs of visually presented objects including overlapping pairs (AB, BC) and nonoverlapping pairs (XY). Participants later completed a three-alternative forced-choice recognition task for studied pairs (AB, BC, XY) and inference pairs (AC). As predicted, the vmPFC group had intact memory for studied pairs but significantly impaired memory for inferential pairs. These results are consistent with the perspective that the vmPFC is necessary for memory-guided associative inference, indicating that the vmPFC is critical for adaptive abilities that require application of existing knowledge to novel circumstances. Additionally, vmPFC damage was associated with unexpectedly reduced memory for AB pairs post-inference, which could potentially reflect retroactive interference. Together, these results reinforce an emerging understanding of a role for the vmPFC in brain networks supporting associative memory processes. SIGNIFICANCE STATEMENT We live in a constantly changing environment, so the ability to adapt our knowledge to support understanding of new circumstances is essential. One important adaptive ability is associative inference which allows us to extract shared features from distinct experiences and relate them. For example, if we see a woman holding a baby, and later see a man holding the same baby, then we might infer that the two adults are a couple. Despite the importance of associative inference, the brain systems necessary for this ability are not known. Here, we report that damage to human ventromedial prefrontal cortex (vmPFC) disproportionately impairs associative inference. Our findings show the necessity of the vmPFC for normal associative inference and memory integration. Copyright © 2018 the authors 0270-6474/18/383767-09$15.00/0.

RNA interference in a cestode reveals specific silencing of selected highly expressed gene transcripts.

PubMed

Pierson, Lisa; Mousley, Angela; Devine, Lynda; Marks, Nikki J; Day, Tim A; Maule, Aaron G

2010-04-01

Evolving RNA interference (RNAi) platforms are providing opportunities to probe gene function in parasitic helminths using reverse genetics. Although relatively robust methods for the application of RNAi in parasitic flatworms have been established, reports of successful RNAi are confined to three genera and there are no known reports of the application of RNAi to the class Cestoda. Here we report the successful application of RNAi to a cestode. Our target species was the common ruminant tapeworm, Moniezia expansa which can significantly impact the health/productivity of cattle, sheep and goats. Initial efforts aimed to silence the neuronally expressed neuropeptide F gene (Me-npf-1), which encodes one of the most abundant neuropeptides in flatworms and a homologue of vertebrate neuropeptide Y (NPY). Double stranded (ds)RNAs, delivered by electroporation and soaking (4-8h), failed to trigger consistent Me-npf-1 transcript knock-down in adult worms; small interfering RNAs (siRNAs) were also ineffective. Identical approaches resulted in significant and consistent transcript knock-down of actin transcript (71+/-4%) following soaking in Me-act-1 dsRNA. Similar successes were seen with hydrophobic lipid-binding protein (Me-lbp-1), with a dsRNA inducing significant target transcript reduction (72+/-5%). To confirm the validity of the observed transcript knock-downs we further investigated Me-act-1 RNAi worms for associated changes in protein levels, morphology and phenotype. Me-act-1 RNAi worms displayed significant reductions in both filamentous actin immunostaining (62+/-3%) and the amount of actin detected in Western blots (54+/-13%). Morphologically, Me-act-1 RNAi worms displayed profound tegumental disruption/blebbing. Further, muscle tension recordings from Me-act-1 RNAi worms revealed a significant reduction in both the number of worms contracting in response to praziquantel (20+/-12%) and in their contractile ability. These data demonstrate, to our knowledge for the first time, a functional RNAi pathway in a cestode and show that the robust knock-down of abundant gene transcripts is achievable using long dsRNAs following short exposure times. 2009 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Pain in ovarian cancer patients. Prevalence, characteristics, and associated symptoms.

PubMed

Portenoy, R K; Kornblith, A B; Wong, G; Vlamis, V; Lepore, J M; Loseth, D B; Hakes, T; Foley, K M; Hoskins, W J

1994-08-01

The prevalence, characteristics, and impact of pain and other symptoms have not been studied systematically in women with ovarian cancer. Anecdotally, pain has been associated with the onset of the disease and is a common problem among those with advanced cancer; symptoms other than pain appear to be highly prevalent. Given the profound influence of pain and other symptoms on quality of life, the evaluation of these phenomena could provide data relevant to the clinical management of these patients and advance quality of life research in the area of symptom assessment. Questionnaires were completed by 111 inpatients and 40 outpatients with ovarian cancer who were undergoing treatment at a cancer center. Measures included a comprehensive pain questionnaire; the Rand Mental Health Inventory, Functional Living Index--Cancer; and the Memorial Symptom Assessment Scale. The sample (N = 151) represented 74% of the eligible patients. The median age was 55 years (range, 23-86), 82% had Stage III or IV disease at presentation, and 69% had active disease at the time of the survey. Pain, fatigue, and psychologic distress were the most prevalent symptoms. Sixty-two percent (N = 94) described a pain syndrome that preceded the onset or recurrence of the disease, and 42% (N = 63) reported "persistent or frequent pain" during the preceding 2 weeks. The latter pain had a median duration of 2 weeks (range, less than 1 to 756 weeks) and usually was in the abdominopelvic region (80%), frequent or almost constant (66%), and moderate to severe. Most patients reported moderate or greater pain-related interference with various aspects of function, particularly activity (68%), mood (62%), work (62%), and overall enjoyment of life (61%). Performance status, inpatient status, and unmarried status were significant predictors of pain presence or intensity, and both performance status and extent of tumor were significant predictors of pain interference with function. Among those with ovarian cancer, greater than 40% experienced pain that substantially undetermined function in one half to two thirds of these patients. Impaired performance status is associated most strongly with pain. The onset or recurrence of disease often is heralded by a stereotypic pain syndrome.

IETS and quantum interference: Propensity rules in the presence of an interference feature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lykkebo, Jacob; Solomon, Gemma C., E-mail: gsolomon@nano.ku.dk; Gagliardi, Alessio

2014-09-28

Destructive quantum interference in single molecule electronics is an intriguing phenomenon; however, distinguishing quantum interference effects from generically low transmission is not trivial. In this paper, we discuss how quantum interference effects in the transmission lead to either low current or a particular line shape in current-voltage curves, depending on the position of the interference feature. Second, we consider how inelastic electron tunneling spectroscopy can be used to probe the presence of an interference feature by identifying vibrational modes that are selectively suppressed when quantum interference effects dominate. That is, we expand the understanding of propensity rules in inelastic electronmore » tunneling spectroscopy to molecules with destructive quantum interference.« less

40 CFR 60.721 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... include conductive sensitizers or electromagnetic interference/radio frequency interference shielding.... Electromagnetic interference/radio frequency interference (EMI/RFI) shielding coating means a conductive coating... coating is applied, not including conductive sensitizers or electromagnetic interference/radio frequency...

40 CFR 60.721 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... include conductive sensitizers or electromagnetic interference/radio frequency interference shielding.... Electromagnetic interference/radio frequency interference (EMI/RFI) shielding coating means a conductive coating... coating is applied, not including conductive sensitizers or electromagnetic interference/radio frequency...

40 CFR 60.721 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... include conductive sensitizers or electromagnetic interference/radio frequency interference shielding.... Electromagnetic interference/radio frequency interference (EMI/RFI) shielding coating means a conductive coating... coating is applied, not including conductive sensitizers or electromagnetic interference/radio frequency...

40 CFR 60.721 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... include conductive sensitizers or electromagnetic interference/radio frequency interference shielding.... Electromagnetic interference/radio frequency interference (EMI/RFI) shielding coating means a conductive coating... coating is applied, not including conductive sensitizers or electromagnetic interference/radio frequency...

40 CFR 60.721 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... include conductive sensitizers or electromagnetic interference/radio frequency interference shielding.... Electromagnetic interference/radio frequency interference (EMI/RFI) shielding coating means a conductive coating... coating is applied, not including conductive sensitizers or electromagnetic interference/radio frequency...

Micro to the Macro Biome Can Biology Affect the Big Picture Through Small Changes?

NASA Technical Reports Server (NTRS)

Morin, Lee

2014-01-01

Life has had a profound impact on the geological history of our planet, which in turn has had a profound impact back on the evolution of life. Life has been able to adapt and spread into every planetary nook and cranny. At this point in history, life is becoming able to engineer itself, with extreme consequences we are only dimly able to foresee. One probable outcome will be the facilitation of the expansion of the range of life to beyond our planetary cradle, an evolutionary step as profound as the ancient transition from sea to land. Current efforts at NASA and aboard the International Space Station will be discussed in this context.

Micro to the Macro Biome: Can Biology Affect the Big Picture Through Small Changes?

NASA Technical Reports Server (NTRS)

Morin, Lee

2014-01-01

Life has had a profound impact on the geological history of our planet, which in turn has had a profound impact back on the evolution of life. Life has been able to adapt and spread into every planetary nook and cranny. At this point in history, life is becoming able to engineer itself, with extreme consequences we are only dimly able to foresee. One probable outcome will be the facilitation of the expansion of the range of life to beyond our planetary cradle, an evolutionary step as profound as the ancient transition from sea to land. Current efforts at NASA and aboard the International Space Station will be discussed in this context.

Perception of persons with severe or profound deafness about the communication process during health care.

PubMed

Cardoso, Adriane Helena Alves; Rodrigues, Karla Gomes; Bachion, Maria Márcia

2006-01-01

This study describes a qualitative approach with the objective of characterizing the perceptions of people with severe or profound deafness about the communication process in the context of health care services. Study participants were 11 people with severe and/or profound deafness, who were interviewed using Brazilian sign language (LIBRAS). The interactions were videotaped and then transcribed. Care was taken to maintain the grammatical construction which was characteristic in the expression of each person. Three categories emerged from thematic analysis: Understanding, Need for Mediation, Feelings. Deaf persons do not achieve effective communication in health care, during which they experience negative feelings. Hence, the presence of a professional interpreter is needed.

Robust X-ray angular correlations for the study of meso-structures

DOE PAGES

Lhermitte, Julien R.; Tian, Cheng; Stein, Aaron; ...

2017-05-08

As self-assembling nanomaterials become more sophisticated, it is becoming increasingly important to measure the structural order of finite-sized assemblies of nano-objects. These mesoscale clusters represent an acute challenge to conventional structural probes, owing to the range of implicated size scales (10 nm to several micrometres), the weak scattering signal and the dynamic nature of meso-clusters in native solution environments. The high X-ray flux and coherence of modern synchrotrons present an opportunity to extract structural information from these challenging systems, but conventional ensemble X-ray scattering averages out crucial information about local particle configurations. Conversely, a single meso-cluster scatters too weakly tomore » recover the full diffraction pattern. Using X-ray angular cross-correlation analysis, it is possible to combine multiple noisy measurements to obtain robust structural information. This paper explores the key theoretical limits and experimental challenges that constrain the application of these methods to probing structural order in real nanomaterials. A metric is presented to quantify the signal-to-noise ratio of angular correlations, and it is used to identify several experimental artifacts that arise. In particular, it is found that background scattering, data masking and inter-cluster interference profoundly affect the quality of correlation analyses. A robust workflow is demonstrated for mitigating these effects and extracting reliable angular correlations from realistic experimental data.« less

Iodide transport: implications for health and disease

PubMed Central

2014-01-01

Disorders of the thyroid gland are among the most common conditions diagnosed and managed by pediatric endocrinologists. Thyroid hormone synthesis depends on normal iodide transport and knowledge of its regulation is fundamental to understand the etiology and management of congenital and acquired thyroid conditions such as hypothyroidism and hyperthyroidism. The ability of the thyroid to concentrate iodine is also widely used as a tool for the diagnosis of thyroid diseases and in the management and follow up of the most common type of endocrine cancers: papillary and follicular thyroid cancer. More recently, the regulation of iodide transport has also been the center of attention to improve the management of poorly differentiated thyroid cancer. Iodine deficiency disorders (goiter, impaired mental development) due to insufficient nutritional intake remain a universal public health problem. Thyroid function can also be influenced by medications that contain iodide or interfere with iodide metabolism such as iodinated contrast agents, povidone, lithium and amiodarone. In addition, some environmental pollutants such as perchlorate, thiocyanate and nitrates may affect iodide transport. Furthermore, nuclear accidents increase the risk of developing thyroid cancer and the therapy used to prevent exposure to these isotopes relies on the ability of the thyroid to concentrate iodine. The array of disorders involving iodide transport affect individuals during the whole life span and, if undiagnosed or improperly managed, they can have a profound impact on growth, metabolism, cognitive development and quality of life. PMID:25009573

Task switching in rhesus macaques (Macaca mulatta) and tufted capuchin monkeys (Cebus apella) during computerized categorization tasks.

PubMed

Smith, Travis R; Beran, Michael J

2018-05-31

The present experiments extended to monkeys a previously used abstract categorization procedure (Castro & Wasserman, 2016) where pigeons had categorized arrays of clipart icons based upon two task rules: the number of clipart objects in the array or the variability of objects in the array. Experiment 1 replicated Castro and Wasserman by using capuchin monkeys and rhesus monkeys and reported that monkeys' performances were similar to pigeons' in terms of acquisition, pattern of errors, and the absence of switch costs. Furthermore, monkeys' insensitivity to the added irrelevant information suggested that an associative (rather than rule-based) categorization mechanism was dominant. Experiment 2 was conducted to include categorization cue reversals to determine (a) whether the monkeys would quickly adapt to the reversals and inhibit interference from a prereversal task rule (consistent with a rule-based mechanism) and (b) whether the latency to make a response prior to a correct or incorrect outcome was informative about the presence of a cognitive mechanism. The cue reassignment produced profound and long-lasting performance deficits, and a long reacquisition phase suggested the involvement of associative learning processes; however, monkeys also displayed longer latencies to choose prior to correct responses on challenging trials, suggesting the involvement of nonassociative processes. Together these performances suggest a mix of associative and cognitive-control processes governing monkey categorization judgments. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Nicotine can modulate the effects of the mesenchymal stem cells on neutrophils.

PubMed

Pourtayeb, Samira; Abtahi Froushani, Seyyed Meysam

2017-03-01

It has been revealed that mesenchymal stem cells (MSCs) express some of the nicotinic receptor subunits. Moreover, the crosstalk between MSCs and neutrophils is not far-fetched. Therefore, the aim of the present study is to determine the role of nicotine on the effects of MSCs on neutrophils. After the isolation of mesenchymal stem cells from the bone marrow of rats, these cells were pulsed with different concentrations of nicotine (0, 0.1, 0.5, and 1μM) for different periods (24, 48, and 72h). Then, the neutrophils were co-cultured with MSCs for 4h and the functions of neutrophils were evaluated. The obtained findings showed that MSCs pulsed with nicotine significantly enhanced the viability and the phagocytic activity of co-cultured neutrophils and simultaneously, decreased the production of reactive oxygen substances (ROS), induced by f-MLP in neutrophils, more profound than MSCs without treatment. Moreover, MSCs, pulsed with nicotine at low to moderate concentrations, preserved the respiratory burst, triggered by opsonized yeast in neutrophils. Nevertheless, a high concentration of nicotine can interfere with the latter aspect of the crosstalk between MSCs and neutrophils. The obtained data can offer a new insight into the potential mechanisms, underlying the immunomodulatory effects of nicotine. Copyright © 2016 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.

Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation

PubMed Central

2012-01-01

Background Distal alveolar morphogenesis is marked by differentiation of alveolar type (AT)-II to AT-I cells that give rise to the primary site of gas exchange, the alveolar/vascular interface. Endothelial-Monocyte Activating Polypeptide (EMAP) II, an endogenous protein with anti-angiogenic properties, profoundly disrupts distal lung neovascularization and alveolar formation during lung morphogenesis, and is robustly expressed in the dysplastic alveolar regions of infants with Bronchopulmonary dysplasia. Determination as to whether EMAP II has a direct or indirect affect on ATII→ATI trans-differentiation has not been explored. Method In a controlled nonvascular environment, an in vitro model of ATII→ATI cell trans-differentiation was utilized to demonstrate the contribution that one vascular mediator has on distal epithelial cell differentiation. Results Here, we show that EMAP II significantly blocked ATII→ATI cell transdifferentiation by increasing cellular apoptosis and inhibiting expression of ATI markers. Moreover, EMAP II-treated ATII cells displayed myofibroblast characteristics, including elevated cellular proliferation, increased actin cytoskeleton stress fibers and Rho-GTPase activity, and increased nuclear:cytoplasmic volume. However, EMAP II-treated cells did not express the myofibroblast markers desmin or αSMA. Conclusion Our findings demonstrate that EMAP II interferes with ATII → ATI transdifferentiation resulting in a proliferating non-myofibroblast cell. These data identify the transdifferentiating alveolar cell as a possible target for EMAP II's induction of alveolar dysplasia. PMID:22214516

Early-life risperidone administration alters maternal-offspring interactions and juvenile play fighting.

PubMed

Gannon, Matthew A; Brown, Clifford J; Stevens, Rachel M; Griffith, Molly S; Marczinski, Cecile A; Bardgett, Mark E

2015-03-01

Risperidone is an antipsychotic drug that is approved for use in childhood psychiatric disorders such as autism. One concern regarding the use of this drug in pediatric populations is that it may interfere with social interactions that serve to nurture brain development. This study used rats to assess the impact of risperidone administration on maternal-offspring interactions and juvenile play fighting between cage mates. Mixed-sex litters received daily subcutaneous injections of vehicle or 1.0 or 3.0mg/kg of risperidone between postnatal days (PNDs) 14-42. Rats were weaned and housed three per cage on PND 21. In observations made between PNDs 14-17, risperidone significantly suppressed several aspects of maternal-offspring interactions at 1-hour post-injection. At 23 h post-injection, pups administered risperidone had lower activity scores and made fewer non-nursing contacts with their moms. In observations of play-fighting behavior made once a week between PNDs 22-42, risperidone profoundly decreased many forms of social interaction at 1h post-injection. At 23h post-injection, rats administered risperidone made more non-social contacts with their cage mates, but engaged in less social grooming. Risperidone administration to rats at ages analogous to early childhood through adolescence in humans produces a pattern of abnormal social interactions across the day that could impact how such interactions influence brain development. Copyright © 2015 Elsevier Inc. All rights reserved.

Involvement of l(-)-rhamnose in sea urchin gastrulation. Part II: α-l-Rhamnosidase.

PubMed

Liang, Jing; Aleksanyan, Heghush; Metzenberg, Stan; Oppenheimer, Steven B

2016-06-01

The sea urchin embryo is recognized as a model system to reveal developmental mechanisms involved in human health and disease. In Part I of this series, six carbohydrates were tested for their effects on gastrulation in embryos of the sea urchin Lytechinus pictus. Only l-rhamnose caused dramatic increases in the numbers of unattached archenterons and exogastrulated archenterons in living, swimming embryos. It was found that at 30 h post-fertilization the l-rhamnose had an unusual inverse dose-dependent effect, with low concentrations (1-3 mM) interfering with development and higher concentrations (30 mM) having little to no effect on normal development. In this study, embryos were examined for inhibition of archenteron development after treatment with α-l-rhamnosidase, an endoglycosidase that removes terminal l-rhamnose sugars from glycans. It was observed that the enzyme had profound effects on gastrulation, an effect that could be suppressed by addition of l-rhamnose as a competitive inhibitor. The involvement of l-rhamnose-containing glycans in sea urchin gastrulation was unexpected, since there are no characterized biosynthetic pathways for rhamnose utilization in animals. It is possible there exists a novel l-rhamnose-containing glycan in sea urchins, or that the enzyme and sugar interfere with the function of rhamnose-binding lectins, which are components of the innate immune system in many vertebrate and invertebrate species.

Morphological and behavioral markers of environmentally induced retardation of brain development: an animal model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Altman, J.

1987-10-01

In most neurotoxicological studies morphological assessment focuses on pathological effects, like degenerative changes in neuronal perikarya, axonopathy, demyelination, and glial and endothelial cell reactions. Similarly, the assessment of physiological and behavioral effects center on evident neurological symptoms, like EEG and EMG abnormalities, resting and intention tremor, abnormal gait, and abnormal reflexes. This paper reviews briefly another central nervous system target of harmful environmental agents, which results in behavioral abnormalities without any qualitatively evident neuropathology. This is called microneuronal hypoplasia, a retardation of brain development characterized by a quantitative reduction in the normal population of late-generated, short-axoned neurons in specific brainmore » regions. Correlated descriptive and experimental neurogenetic studies in the rat have established that all the cerebellar granule cells and a very high proportion of hippocampal granule cells are produced postnatally, and that focal, low-dose X-irradiation either of the cerebellum or of the hippocampus after birth selectively interferes with the acquisition of the full complement of granule cells (microneuronal hypoplasia). Subsequent behavioral investigations showed that cerebellar microneuronal hypoplasia results in profound hyperactivity without motor abnormalities, while hippocampal microneuronal hypoplasia results in hyperactivity, as well as attentional and learning deficits. There is much indirect clinical evidence that various harmful environmental agents affecting the pregnant mother and/or the infant lead to such childhood disorders as hyperactivity and attentional and learning disorders. 109 references.« less

A status report on RNAi therapeutics

PubMed Central

2010-01-01

Fire and Mello initiated the current explosion of interest in RNA interference (RNAi) biology with their seminal work in Caenorhabditis elegans. These observations were closely followed by the demonstration of RNAi in Drosophila melanogaster. However, the full potential of these new discoveries only became clear when Tuschl and colleagues showed that 21-22 bp RNA duplexes with 3" overhangs, termed small interfering (si)RNAs, could reliably execute RNAi in a range of mammalian cells. Soon afterwards, it became clear that many different human cell types had endogenous machinery, the RNA-induced silencing complex (RISC), which could be harnessed to silence any gene in the genome. Beyond the availability of a novel way to dissect biology, an important target validation tool was now available. More importantly, two key properties of the RNAi pathway - sequence-mediated specificity and potency - suggested that RNAi might be the most important pharmacological advance since the advent of protein therapeutics. The implications were profound. One could now envisage selecting disease-associated targets at will and expect to suppress proteins that had remained intractable to inhibition by conventional methods, such as small molecules. This review attempts to summarize the current understanding on siRNA lead discovery, the delivery of RNAi therapeutics, typical in vivo pharmacological profiles, preclinical safety evaluation and an overview of the 14 programs that have already entered clinical practice. PMID:20615220

Architectural and biochemical adaptations in skeletal muscle and bone following rotator cuff injury in a rat model.

PubMed

Sato, Eugene J; Killian, Megan L; Choi, Anthony J; Lin, Evie; Choo, Alexander D; Rodriguez-Soto, Ana E; Lim, Chanteak T; Thomopoulos, Stavros; Galatz, Leesa M; Ward, Samuel R

2015-04-01

Injury to the rotator cuff can cause irreversible changes to the structure and function of the associated muscles and bones. The temporal progression and pathomechanisms associated with these adaptations are unclear. The purpose of this study was to investigate the time course of structural muscle and osseous changes in a rat model of a massive rotator cuff tear. Supraspinatus and infraspinatus muscle architecture and biochemistry and humeral and scapular morphological parameters were measured three days, eight weeks, and sixteen weeks after dual tenotomy with and without chemical paralysis via botulinum toxin A (BTX). Muscle mass and physiological cross-sectional area increased over time in the age-matched control animals, decreased over time in the tenotomy+BTX group, and remained nearly the same in the tenotomy-alone group. Tenotomy+BTX led to increased extracellular collagen in the muscle. Changes in scapular bone morphology were observed in both experimental groups, consistent with reductions in load transmission across the joint. These data suggest that tenotomy alone interferes with normal age-related muscle growth. The addition of chemical paralysis yielded profound structural changes to the muscle and bone, potentially leading to impaired muscle function, increased muscle stiffness, and decreased bone strength. Structural musculoskeletal changes occur after tendon injury, and these changes are severely exacerbated with the addition of neuromuscular compromise. Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.

Early-Life Risperidone Administration Alters Maternal-Offspring Interactions and Juvenile Play Fighting

PubMed Central

Gannon, Matthew A.; Brown, Clifford J.; Stevens, Rachel M.; Griffith, Molly S.; Marczinski, Cecile A.; Bardgett, Mark E.

2015-01-01

Risperidone is an antipsychotic drug that is approved for use in childhood psychiatric disorders such as autism. One concern regarding the use of this drug in pediatric populations is that it may interfere with social interactions that serve to nurture brain development. This study used rats to assess the impact of risperidone administration on maternal-offspring interactions and juvenile play fighting between cage mates. Mixed-sex litters received daily subcutaneous injections of vehicle or 1.0 or 3.0 mg/kg of risperidone between postnatal days (PNDs) 14-42. Rats were weaned and housed three per cage on PND 21. In observations made between PNDs 14-17, risperidone significantly suppressed several aspects of maternal-offspring interactions at one-hour post-injection. At 23 hours post-injection, pups administered risperidone had lower activity scores and made fewer non-nursing contacts with their moms. In observations of play-fighting behavior made once a week between PNDs 22-42, risperidone profoundly decreased many forms of social interaction at one hour post-injection. At 23 hours post-injection, rats administered risperidone made more non-social contacts with their cage mates, but engaged in less social grooming. Risperidone administration to rats at ages analogous to early childhood through adolescence in humans produces a pattern of abnormal social interactions across the day that could impact how such interactions influence brain development. PMID:25600754

Detection of DNA–protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs

PubMed Central

Shoulkamy, Mahmoud I.; Nakano, Toshiaki; Ohshima, Makiko; Hirayama, Ryoichi; Uzawa, Akiko; Furusawa, Yoshiya; Ide, Hiroshi

2012-01-01

Proteins are covalently trapped on DNA to form DNA–protein crosslinks (DPCs) when cells are exposed to DNA-damaging agents. DPCs interfere with many aspects of DNA transactions. The current DPC detection methods indirectly measure crosslinked proteins (CLPs) through DNA tethered to proteins. However, a major drawback of such methods is the non-linear relationship between the amounts of DNA and CLPs, which makes quantitative data interpretation difficult. Here we developed novel methods of DPC detection based on direct CLP measurement, whereby CLPs in DNA isolated from cells are labeled with fluorescein isothiocyanate (FITC) and quantified by fluorometry or western blotting using anti-FITC antibodies. Both formats successfully monitored the induction and elimination of DPCs in cultured cells exposed to aldehydes and mouse tumors exposed to ionizing radiation (carbon-ion beams). The fluorometric and western blotting formats require 30 and 0.3 μg of DNA, respectively. Analyses of the isolated genomic DPCs revealed that both aldehydes and ionizing radiation produce two types of DPC with distinct stabilities. The stable components of aldehyde-induced DPCs have half-lives of up to days. Interestingly, that of radiation-induced DPCs has an infinite half-life, suggesting that the stable DPC component exerts a profound effect on DNA transactions over many cell cycles. PMID:22730301

Deming's System of Profound Knowledge: An Overview for International Educators.

ERIC Educational Resources Information Center

Evans, Thomas J.

W. Edwards Deming called for the transformation to a new style of organizational management based on greater cooperation between managers and employees. This transformation could be achieved by introducing "profound knowledge" into the system. This paper is a presentation outline that was used to introduce the basics of Deming's theory…

You Should be Dancin:! The Role of Performing Arts in the Lives of the Severely and Profoundly Handicapped.

ERIC Educational Resources Information Center

Barringer, Mary Dean

The manual presents a program planning framework and teaching units for teaching dance and movement to severely and profoundly handicapped individuals. The planning framework contains four components: (1) aesthetic perception/multisensory integration; (2) creative expression; (3) dance heritage/historical and cultural; and (4) aesthetic…

A Data Based Multidimensional Oral Hygiene Curriculum for the Severely and Profoundly Handicapped.

ERIC Educational Resources Information Center

Feldman, David; Elliott, Thomas A.

A multidimensional oral hygiene curriculum appropriate for the moderately to profoundly retarded and composed of tooth brushing, flossing, and gum stimulation/massage is proposed. Task analyses are included for manual tooth brushing, utilizing an oral irrigation appliance, manual flossing, and use of an adaptive aid for flossing. Also provided are…

Making Sense of Bereavement in People with Profound Intellectual and Multiple Disabilities: Carer Perspectives

ERIC Educational Resources Information Center

Young, Hannah; Hogg, James; Garrard, Brenda

2017-01-01

Background: People with intellectual disabilities are thought to have a reduced capacity for understanding death. Drawing on cognitive theory, researchers have suggested that those with profound intellectual and multiple disabilities mainly perceive loss as a mismatch between past and present experiences. However, very little research has…

The Prevalence and Characteristics of Tinnitus with Profound Sensori-Neural Hearing Impairment.

ERIC Educational Resources Information Center

Drukier, Gale S.

1989-01-01

Of 331 children (aged 6-18) with profound hearing impairment, 96 were found to have tinnitus. More females than males reported tinnitus. Most of the children with tinnitus were bothered to some degree by it and indicated that the noises adversely affected their ability to hear voices. (JDD)

A Grounded Theory of Effective Reading by Profoundly Deaf Adults

ERIC Educational Resources Information Center

Silvestri, Julia; Wang, Ye

2018-01-01

The purpose of the study was to uncover and describe psycholinguistic and sociocognitive factors facilitating effective reading by signing adults who are profoundly deaf and do not use hearing technology. The sample comprised four groups, each consisting of 15 adults, for a total of 60 participants. The four groups were "deaf…

Music Training for Severely and Profoundly Retarded Individuals.

ERIC Educational Resources Information Center

Kesler, Buford; Richmond, Bert O.

Investigated were the effects of sex, ability and training method on the musical instrument playing ability of 16 institutionalized severely and profoundly retarded persons ages 7 to 20 years. Ss were randomly assigned to one of four treatment groups, and the time required to reach criterion playing a familiar tune was recorded. Data indicated…

EEG Alpha and Beta Activity in Normal and Deaf Subjects.

ERIC Educational Resources Information Center

Waldron, Manjula; And Others

Electroencephalogram and task performance data were collected from three groups of young adult males: profoundly deaf Ss who signed from an early age, profoundly deaf Ss who only used oral (speech and speedreading) methods of communication, and normal hearing Ss. Alpha and Beta brain wave patterns over the Wernicke's area were compared across…

Habilitation of Severely and Profoundly Retarded Adults: Reports from the Specialized Training Program.

ERIC Educational Resources Information Center

Bellamy, G. Thomas, Ed.

Presented are 11 reports resulting from applied research of the Specialized Training Program at the University of Oregon, a subcontract workshop for 15 severely and profoundly retarded adults which focuses on the areas of vocational potential and community program development. Entries include the following titles and authors: "Habilitation of the…

Demographic Characteristics and Impairments of Louisiana Students with Usher's Syndrome.

ERIC Educational Resources Information Center

Brown, S. C.

1987-01-01

Of 51 Louisiana students with Usher's Syndrome (a genetic condition characterized by hearing loss and progressive blindness), 71 percent manifested visual impairment and hearing loss, 9 percent had neither, 10 percent had visual impairments but a less-than-profound hearing loss, and 10 percent had profound hearing loss and no visual impairment.…

Speech and Language Therapists' Approaches to Communication Intervention with Children and Adults with Profound and Multiple Learning Disability

ERIC Educational Resources Information Center

Goldbart, Juliet; Chadwick, Darren; Buell, Susan

2014-01-01

Background: People with profound intellectual and multiple disabilities (PMLD) have communication impairments as one defining characteristic. Aims: To explore speech and language therapists' (SLTs) decision making in communication interventions for people with PMLD, in terms of the intervention approaches used, the factors informing the decisions…