Sample records for program announcements pas

  1. Ford Partnership for Advanced Studies (Ford PAS)

    ERIC Educational Resources Information Center

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  2. Skills Decay in Military Medical Training: A Meta-synthesis of Research Outcomes.

    PubMed

    Linde, Amber S; Caridha, Jona; Kunkler, Kevin J

    2018-01-01

    In fiscal year 2012, the Medical Simulation and Information Sciences Research Program released two Skills Decay (SD) research program announcements (PAs) under the Medical Readiness Initiative entitled "Medical Practice Initiative Breadth of Medical Practice & Disease Frequency Exposure (MPI-BMP)" and the "Medical Practice Initiative Procedural Skill Decay and Maintenance (MPI-PSD)." The Office of Naval Research also released a PA entitled "Medical Modeling and Simulation (MM&S) for Military Training and Education." A total investment of $12 M was made. This article provides a meta-synthesis of the Skills Decay research conducted under these efforts. The MSIRRP Medical Simulation Portfolio collected, reviewed, and analyzed the final reports of the Skills Decay research efforts from the three PAs. This paper provides a meta-synthesis of the outcomes of those studies. Focus of this study was to determine if the anticipated goals of the Skills Decay PAs were met as well as to provide a summary of lessons learned to the research community. Fourteen research questions posed by the PAs were structured into four main goals: (1) Skills Decay identification, (2) creation/validity of Skills Decay tools and feasibility and viability of data extraction project, (3) refreshment training to prevent or alleviate Skills Decay project, and (4) Skills Decay education content. Using a combination of training styles, choosing variables known to have Skills Decay predication value, and developing better ways of mining available data that can, in turn, provide feedback to training needs, it is possible for accurate Skills Decay models to be developed. These technologies have the ability not only capture the learner's reaction during the simulation, but to capture the simulation outcomes to predict a medical professional's level of experience and background. Lessons learned from the investments made by the government are extremely important in order to ensure that the outcomes of the research touch the lives of the warfighter. Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  3. Aircraft noise prediction program propeller analysis system IBM-PC version user's manual version 2.0

    NASA Technical Reports Server (NTRS)

    Nolan, Sandra K.

    1988-01-01

    The IBM-PC version of the Aircraft Noise Prediction Program (ANOPP) Propeller Analysis System (PAS) is a set of computational programs for predicting the aerodynamics, performance, and noise of propellers. The ANOPP-PAS is a subset of a larger version of ANOPP which can be executed on CDC or VAX computers. This manual provides a description of the IBM-PC version of the ANOPP-PAS and its prediction capabilities, and instructions on how to use the system on an IBM-XT or IBM-AT personal computer. Sections within the manual document installation, system design, ANOPP-PAS usage, data entry preprocessors, and ANOPP-PAS functional modules and procedures. Appendices to the manual include a glossary of ANOPP terms and information on error diagnostics and recovery techniques.

  4. Interservice Physician Assistant Program: Educators for an Expanding Profession.

    PubMed

    Brock, Douglas M; Orrahood, Scott A; Cooper, Christopher K; Alvitre, John J; Tozier, William

    2017-10-01

    The number of physician assistant (PA) programs has increased exponentially across the past decade, and the demand for PAs will likely remain strong through 2025. Because of this rapid growth, both new and established PA programs face significant challenges in recruiting experienced educators. We describe the value of using PAs trained through the Interservice Physician Assistant Program (IPAP) as civilian PA educators. The literature on IPAP and its graduates proved too limited to conduct a formal systematic review. We searched the PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases for works speaking to the value that IPAP-trained PAs may bring to civilian PA training. Those findings were supplemented with informal conversations with IPAP-trained PAs currently employed in the military and those working in civilian PA education. Themes were identified supporting the potential value of IPAP-trained PAs in civilian training. Military PAs work within hierarchical organizations and may transition easily to academic settings. They leave military service not only as highly trained and proficient primary care providers but also as experienced educators. Military PAs must demonstrate professionalism across their entire military careers. They serve as leaders and work in teams, but they are also experienced in negotiating up chains of command. They are trained in and apply the latest innovations in health care delivery and have provided care with a degree of autonomy uncommon in civilian PA practice. The PAs trained through IPAP leave the service with skills and experiences valuable to civilian PA training. Employing these PAs in civilian education honors their service contributions while addressing emerging PA educator workforce demands.

  5. NASA pyrotechnically actuated systems program

    NASA Technical Reports Server (NTRS)

    Schulze, Norman R.

    1993-01-01

    The Office of Safety and Mission Quality initiated a Pyrotechnically Actuated Systems (PAS) Program in FY-92 to address problems experienced with pyrotechnically actuated systems and devices used both on the ground and in flight. The PAS Program will provide the technical basis for NASA's projects to incorporate new technological developments in operational systems. The program will accomplish that objective by developing/testing current and new hardware designs for flight applications and by providing a pyrotechnic data base. This marks the first applied pyrotechnic technology program funded by NASA to address pyrotechnic issues. The PAS Program has been structured to address the results of a survey of pyrotechnic device and system problems with the goal of alleviating or minimizing their risks. Major program initiatives include the development of a Laser Initiated Ordnance System, a pyrotechnic systems data base, NASA Standard Initiator model, a NASA Standard Linear Separation System and a NASA Standard Gas Generator. The PAS Program sponsors annual aerospace pyrotechnic systems workshops.

  6. A Comparison of the Structural Factors of the Propensity for Abusiveness Scale for Women and Men in a Domestic Violence Treatment Program.

    PubMed

    Allen, Christopher T; Swan, Suzanne C; Maas, Carl D; Barber, Sara

    2015-08-01

    Court-mandated domestic violence (DV) treatment programs across the country have seen a marked increase in female clients. These programs use a variety of measurement tools to assess the needs of their clients. Increased numbers of women in treatment for DV reflect a need to address the measurement of intimate partner violence (IPV) for both males and females. Unfortunately, the reliability and validity of many of measures used to assess IPV and related constructs for women remains unknown. The current study focuses on a particular measure, the Propensity for Abusiveness Scale (PAS). The PAS is not a measure of abusive behavior per se; rather, it assesses risk factors for abuse, including affective lability, anger expression, trauma symptoms, and harsh parenting experienced by the respondent. Specifically, the current study compares the factor structure and the measurement properties of the PAS for males and females in a sample of 885 (647 female, 238 male) participants in a DV treatment program. Findings indicate that the PAS demonstrated configural, metric, and scalar invariance between the female and male samples. These results suggest that it is appropriate for researchers and clinicians to make comparisons between women and men based on PAS factor scores. © The Author(s) 2014.

  7. PDES Application Protocol Suite for Composites (PAS-C). Functional Needs Report for the PAS-C Program

    DTIC Science & Technology

    1991-09-01

    103 A2352344 Layup Cover Sheets/Inspect ............................. 103 A2352345 Perform Automated Tape Laying operations...A2352345 Perform Automated Tape Laying operations/Inspect The tape is layed in 3-12 inch strips along the surface of the bond mold. The NC program is

  8. Impact of payments for environmental services and protected areas on local livelihoods and forest conservation in northern Cambodia.

    PubMed

    Clements, Tom; Milner-Gulland, E J

    2015-02-01

    The potential impacts of payments for environmental services (PES) and protected areas (PAs) on environmental outcomes and local livelihoods in developing countries are contentious and have been widely debated. The available evidence is sparse, with few rigorous evaluations of the environmental and social impacts of PAs and particularly of PES. We measured the impacts on forests and human well-being of three different PES programs instituted within two PAs in northern Cambodia, using a panel of intervention villages and matched controls. Both PES and PAs delivered additional environmental outcomes relative to the counterfactual: reducing deforestation rates significantly relative to controls. PAs increased security of access to land and forest resources for local households, benefiting forest resource users but restricting households' ability to expand and diversify their agriculture. The impacts of PES on household well-being were related to the magnitude of the payments provided. The two higher paying market-linked PES programs had significant positive impacts, whereas a lower paying program that targeted biodiversity protection had no detectable effect on livelihoods, despite its positive environmental outcomes. Households that signed up for the higher paying PES programs, however, typically needed more capital assets; hence, they were less poor and more food secure than other villagers. Therefore, whereas the impacts of PAs on household well-being were limited overall and varied between livelihood strategies, the PES programs had significant positive impacts on livelihoods for those that could afford to participate. Our results are consistent with theories that PES, when designed appropriately, can be a powerful new tool for delivering conservation goals whilst benefiting local people. © 2014 The Authors. Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

  9. Predictive Modeling the Physician Assistant Supply: 2010–2025

    PubMed Central

    Hooker, Roderick S.; Cawley, James F.; Everett, Christine M.

    2011-01-01

    Objective A component of health-care reform in 2010 identified physician assistants (PAs) as needed to help mitigate the expected doctor shortage. We modeled their number to predict rational estimates for workforce planners. Methods The number of PAs in active clinical practice in 2010 formed the baseline. We used graduation rates and program expansion to project annual growth; attrition estimates offset these amounts. A simulation model incorporated historical trends, current supply, and graduation amounts. Sensitivity analyses were conducted to systematically adjust parameters in the model to determine the effects of such changes. Results As of 2010, there were 74,476 PAs in the active workforce. The mean age was 42 years and 65% were female. There were 154 accredited educational programs; 99% had a graduating class and produced an average of 44 graduates annually (total n=6,776). With a 7% increase in graduate entry rate and a 5% annual attrition rate, the supply of clinically active PAs will grow to 93,099 in 2015, 111,004 in 2020, and 127,821 in 2025. This model holds clinically active PAs in primary care at 34%. Conclusions The number of clinically active PAs is projected to increase by almost 72% in 15 years. Attrition rates, especially retirement patterns, are not well understood for PAs, and variation could affect future supply. While the majority of PAs are in the medical specialties and subspecialties fields, new policy steps funding PA education and promoting primary care may add more PAs in primary care than the model predicts. PMID:21886331

  10. OHD/SRC - Past Announcement

    Science.gov Websites

    Collaborative Research Program Current Announcement Past Announcements Collaborative Research Projects General services. Past Announcements FRN Announcement Questions and Answers Main Link Categories: Home | OHD | NWS

  11. Developing leaders: implementation of a peer advising program for a public health sciences undergraduate program.

    PubMed

    Griffin, Megan; DiFulvio, Gloria T; Gerber, Daniel Shea

    2014-01-01

    Peer advising is an integral part of our undergraduate advising system in the Public Health Sciences major at the University of Massachusetts Amherst. The program was developed in 2009 to address the advising needs of a rapidly growing major that went from 25 to over 530 majors between 2007 and 2014. Each year, 9-12 top performing upper-level students are chosen through an intensive application process. A major goal of the program is to provide curriculum and career guidance to students in the major and empower students in their academic and professional pursuits. The year-long program involves several components, including: staffing the drop-in advising center, attending training seminars, developing and presenting workshops for students, meeting prospective students and families, evaluating ways to improve the program, and collaborating on self-directed projects. The peer advisors (PAs) also provide program staff insight into the needs and perspectives of students in the major. In turn, PAs gain valuable leadership and communication skills, and learn strategies for improving student success. The Peer Advising Program builds community and fosters personal and professional development for the PAs. In this paper, we will discuss the undergraduate peer advising model, the benefits and challenges of the program, and lessons learned. Several methods were used to understand the perceived benefits and challenges of the program and experiences of students who utilized the Peer Advising Center. The data for this evaluation were drawn from three sources: (1) archival records from the Peer Advising Center; (2) feedback from PAs who completed the year-long internship; and (3) a survey of students who utilized the Peer Advising Center. Results of this preliminary evaluation indicate that PAs gain valuable skills that they can carry into their professional world. The program is also a way to engage students in building community within the major.

  12. Senescence and programmed cell death in plants: polyamine action mediated by transglutaminase

    PubMed Central

    Del Duca, Stefano; Serafini-Fracassini, Donatella; Cai, Giampiero

    2014-01-01

    Research on polyamines (PAs) in plants laps a long way of about 50 years and many roles have been discovered for these aliphatic cations. PAs regulate cell division, differentiation, organogenesis, reproduction, dormancy-break and senescence, homeostatic adjustments in response to external stimuli and stresses. Nevertheless, the molecular mechanisms of their multiple activities are still matter of research. PAs are present in free and bound forms and interact with several important cell molecules; some of these interactions may occur by covalent linkages catalyzed by transglutaminase (TGase), giving rise to “cationization” or cross-links among specific proteins. Senescence and programmed cell death (PCD) can be delayed by PAs; in order to re-interpret some of these effects and to obtain new insights into their molecular mechanisms, their conjugation has been revised here. The TGase-mediated interactions between proteins and PAs are the main target of this review. After an introduction on the characteristics of this enzyme, on its catalysis and role in PCD in animals, the plant senescence and PCD models in which TGase has been studied, are presented: the corolla of naturally senescing or excised flowers, the leaves senescing, either excised or not, the pollen during self-incompatible pollination, the hypersensitive response and the tuber storage parenchyma during dormancy release. In all the models examined, TGase appears to be involved by a similar molecular mechanism as described during apoptosis in animal cells, even though several substrates are different. Its effect is probably related to the type of PCD, but mostly to the substrate to be modified in order to achieve the specific PCD program. As a cross-linker of PAs and proteins, TGase is an important factor involved in multiple, sometimes controversial, roles of PAs during senescence and PCD. PMID:24778637

  13. After CLASS--Is a voluntary public insurance program a realistic way to meet the long-term support and service needs of adults with disabilities?

    PubMed

    Kennedy, Jae; Gimm, Gilbert; Glazier, Raymond

    2016-04-01

    The CLASS Act, which was part of the Affordable Care Act of 2010, established a voluntary personal assistance services (PAS) insurance program. However, concerns about enrollment and adverse selection led to repeal of the CLASS Act in 2013. To estimate the number of middle-aged adults interested in purchasing PAS insurance, the sociodemographic, socioeconomic and disability attributes of this population, and the maximum monthly premium they would be willing to pay for such coverage. A total of 13,384 adults aged 40-65 answered questions about their interest in PAS insurance in the 2011 Sample Adult National Health Interview Survey. We applied survey weights for the U.S. population and conducted logistic regression analyses to identify personal factors associated with interest in paying for the CLASS program. An estimated 25.8 million adults aged 40-65 (26.7%) said they would be interested in paying for a public insurance program to cover PAS benefits. However, interest in PAS insurance varied by age, race, ethnicity, region, income, disability status, and family experience with ADL assistance. Only 1.6 million adults aged 40-65 (1.8%) said they would be willing to pay $100 per month or more for coverage. While more than a quarter of the middle-aged adult population said they were interested in PAS insurance, actual participation would be highly dependent on premium rates. The current lack of publicly subsidized insurance for long-term care and personal assistance services remains a serious gap in the disability service system. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Return on investment of advanced practice medical degrees: NPs vs. PAs.

    PubMed

    Craig, Christopher K; Holmes, James H; Carter, Jeffery E

    2017-06-01

    As the United States faces a predicted physician shortage over the next 2 decades, physician assistants (PAs) and NPs are expected to fill the void. At the same time, because education is expensive, student loan and tuition increases have many potential applicants assessing differences in reimbursement and wondering about their return on investment (ROI). An analysis compared PA and NP salaries by incorporating national salary data, federal income tax, and student loans for a comparative analysis of each career pathway. Salaries were abstracted from the 2012 Bureau of Labor Statistics database. The net present value (NPV) of PA and NP salaries was calculated with a 5% discount rate. Principal and interest for student loans was calculated at a 6% interest fixed-rate loan over 30 years. NPVs were then compared with projected ROI at retirement age. Relative career values were also given to each career choice, based on a retirement age of 65 years, which translates to about 41 years of employment for both PAs and NPs. PAs' and NPs' educational loans both equalled $129,484 on total repayment. The median annual salary of a PA was $90,930 and $89,960 for an NP. PA data yielded a 5% NPV of $781,323 compared with $764,348 for NPs. Of note, the 5% NPV of a 4-year nursing degree is $728,436. PAs have a slightly higher ROI compared with NPs. These findings may change due to adjustments in nursing training models. Many PA programs allow matriculation immediately after obtaining a bachelor's degree. NP schools often require nursing experience before entering their program. Some schools are considering an accelerated NP program, allowing immediate matriculation after obtaining a bachelor's degree. Because many NP programs have become doctoral degrees, the increased duration of training, higher tuition, and fewer years worked before retirement lower the overall NP ROI. A similar reduction in ROI was considered marginal in PAs who attend residency programs-though these programs are not required for PAs to practice. Comparison of an RN with a 4-year degree to an NP shows little increase in ROI. If interest rates rise, it will become fiscally preferable to remain in a nursing position. Other intangible qualities exist and need further research (for example, weighing the financial aspects with lifestyle or professional satisfaction).

  15. 77 FR 58404 - Announcing the Award of Two Urgent Single-Source Grants To Support Unaccompanied Alien Children...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ...] Announcing the Award of Two Urgent Single-Source Grants To Support Unaccompanied Alien Children Program...) announces the award of two urgent single-source grants from the Unaccompanied Alien Children's Program to... providing services under the Unaccompanied Alien Children's program. Award Grantee organization Location...

  16. 5 CFR 362.403 - Announcement, eligibility, and selection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Announcement, eligibility, and selection. 362.403 Section 362.403 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Presidential Management Fellows Program § 362.403 Announcement, eligibility, and...

  17. 5 CFR 362.403 - Announcement, eligibility, and selection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Announcement, eligibility, and selection. 362.403 Section 362.403 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Presidential Management Fellows Program § 362.403 Announcement, eligibility, and...

  18. 78 FR 8552 - Announcement of Funding Awards, HOPE VI Main Street Grant Program, Fiscal Year (FY) 2011 and 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Program. This announcement contains the consolidated names and addresses of the award recipients under... Awards, HOPE VI Main Street Grant Program, Fiscal Year (FY) 2011 and 2012 AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION: Announcement of funding awards. SUMMARY: In accordance...

  19. 75 FR 71137 - Announcement of Funding Awards for the HOPE VI Revitalization Grant Program for Fiscal Year 2009

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... grant program. This announcement contains the names and addresses of this FY 2009's award recipients... Awards for the HOPE VI Revitalization Grant Program for Fiscal Year 2009 AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION: Announcement of funding awards. SUMMARY: In accordance...

  20. Assessment of Light Pollution Impact on Protected Areas in China

    NASA Astrophysics Data System (ADS)

    Jiang, W.; He, G.; Ni, Y.

    2017-09-01

    The Protected Areas (PAs) with natural, ecological and cultural value play important role in biological processes, biodiversity and ecosystem service. During the past years of rapid urban expansion in China, the spatial range and intensity of light pollution unprecedented increase. Historically, optical remote sensing and field survey data had been used to reveal that human activities impacted on PAs for individual areas and few papers documented the issue of light pollution impact on PAs at national scale. Here, time series night-time light satellite images of Defense Meteorological Satellite Program Operational Linescan System (DMSP-OLS) were selected to assess the light pollution impacted on PAs in China. The method we proposed can be effectively applied to assess the impact of light pollution on PAs and the percent of dark PAs decreased by 35.38 % from 1992 to 2012 at nationwide. The trend of light pollution of most PAs in stable, however, light pollution of the local area is increase significantly, especially in northern Xinjiang, Gansu, Xizang, Yunnan, Jiangsu and Shandong. Considering the current status of light pollution encroach into PAs, two strategies of appropriate buffer zone and wide measured for light pollution are also recommend.

  1. 7 CFR 1435.601 - Sugar surplus determination and public announcement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Sugar surplus determination and public announcement...) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Feedstock Flexibility Program § 1435.601 Sugar surplus determination and public announcement. (a) CCC will...

  2. 78 FR 2413 - Office of Urban Indian Health Programs; Announcement Type: Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Indian Health Service Office of Urban Indian Health Programs; Announcement Type: Meeting Notice AGENCY: Indian Health Service, HHS. ACTION: Meeting Notice. SUMMARY: The purpose of this Notice is to announce an Indian Health Service (IHS) Listening Session on the...

  3. 76 FR 19356 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 11-390] Video Programming and Accessibility Advisory.... SUMMARY: This document announces the next meeting of the Video Programming Accessibility Advisory... Internet programming previously captioned on television, video description of television programming...

  4. Innovative Molecular Analysis Technologies Program Funding Opportunities | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    The NCI is very pleased to announce that the Innovative Molecular Analysis Technologies (IMAT) program funding opportunity announcements have been posted for calendar year (CY) 2013. Please visit this website for more information on these announcements. For your convenience, a link to each solicitation is provided below with associated submission deadlines for new applications and resubmissions. Please contact the NCI IMAT program director, Dr.

  5. 77 FR 14538 - Announcement of Funding Awards Family Unification Program (FUP) Fiscal Year (FY) 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... announcement contains the consolidated names and addresses of the award recipients for this year under the FUP.... Appendix A Fiscal Year 2010 Funding Awards for the Family Unification Program Recipient Address City State... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. 5415-FA-15] Announcement of Funding Awards...

  6. 78 FR 72095 - Announcement of Funding Awards for Fiscal Year 2013 Research Partnerships Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Awards for Fiscal Year 2013 Research Partnerships Program AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION: Announcement of funding awards. SUMMARY: In accordance with... Unsolicited Research Proposals. The purpose of this document is to announce the names and addresses of the...

  7. The role of advanced practice providers in pediatric otolaryngology academic practices.

    PubMed

    Reilly, Brian K; Brandon, Gretchen; Shah, Rahul; Preciado, Diego; Zalzal, George

    2013-01-01

    The goal of this study was to examine the roles of Physician Assistants (PAs) and Nurse Practitioners (NPs) in pediatric academic otolaryngology programs to provide a better understanding of their scope of practice, levels of autonomy, clinical duties, teaching opportunities and research participation. An anonymous web-based electronic survey tool was sent to all pediatric otolaryngology fellowship program directors in the United States. Nurse Practitioners and Physician Assistants are utilized in approximately 3 out of every 4 pediatric otolaryngology practices. The top three job activities of both the PA and NP were: (1) seeing patients independently, (2) working alongside doctors in clinic, and (3) answering phone lines/parental calls. A higher percentage of PAs (83%), worked alongside doctors in clinic, as compared to NPs, where only 55% work alongside MDs. Over half of PAs round with the in-patient team and see consults as compared to just over one third of NPs who participate in such activities. Twenty-five percent of practices reported that PAs cover call and assist in the OR. Most PAs/NPs saw between 11 and 15 patients per clinic which provides a clear productivity advantage when looking to screen patients, provide medical care, generate surgical cases, and maximize billings. NPs and PAs have complimentary skill sets ideal for the pediatric otolaryngology workplace, although job activities and "best fit" are hospital and practice dependent. Our study suggests that the use of PAs and NPs will continue to grow to meet increased demand for services in the field of pediatric otolaryngology. Employing advanced practice providers enables academic centers to improve access, provide additional financial remuneration, reduce wait times for new patients, and allow attending physicians to meet increased practice demands. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  8. 48 CFR 15.604 - Agency points of contact.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... agency: upcoming solicitations; Broad Agency Announcements; Small Business Innovation Research programs; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 15.604 Agency points...

  9. 14 CFR 1214.1101 - Announcement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Recruitment and Selection Program § 1214.1101 Announcement. (a) Astronaut candidate opportunities Will be... Opportunity Programs, NASA Headquarters, will provide assistance in the recruiting process. [54 FR 37940, Sept...

  10. 76 FR 6810 - Announcement of Funding Awards for the Special Needs Assistance Programs-Technical Assistance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ...In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of funding decisions made by the Department in a competition for funding under the Notice of Funding Availability (NOFA) for the Special Needs Assistance Programs Technical Assistance program. This announcement contains the names of the awardees and amounts of the awards made available by HUD.

  11. 76 FR 31241 - Prevention of Significant Deterioration (PSD) Program; Massachusetts; Announcing Delegation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Deterioration (PSD) Program; Massachusetts; Announcing Delegation Agreement Between EPA and Massachusetts... authority to implement and enforce the Federal Prevention of Significant Deterioration (PSD) program to the MassDEP. Therefore, effective that date, MassDEP is the implementing authority for the PSD program in...

  12. 77 FR 6113 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-15] Video Programming and Accessibility Advisory.... SUMMARY: This document announces the next meeting of the Video Programming Accessibility Advisory... Commission regarding the provision of video description, access to emergency programming, and access to user...

  13. PAs: Fifty years young.

    PubMed

    Mandel, Ellen D; North, Shannon

    2017-10-01

    The PA profession is 50 years young. Practicing PAs and current students hail from several generational categories ranging from Builders to Generation Z. This article reviews how different generations may have experienced PA program expansion, professional identity, state licensing, and prescription delegation. The authors sampled a cohort of PA program applicants about their views on what evokes optimism and concern for the PA profession. These themes mirror the recently paved professional road, while posing the all-important question: What construction lies on the horizon?

  14. OHD/SRC - Science Research and Collaboration

    Science.gov Websites

    Collaborative Research Program Current Announcement Past Announcements Collaborative Research Projects General Science Plan in Adobe pdf format. OHD Seminars. Recordings of past OHD seminars are posted on this page . The Current Announcement and Past Announcement sections display the text of the respective

  15. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Research Announcements... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1835.016-71 NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and...

  16. Announcements under Renewable Fuel Standard

    EPA Pesticide Factsheets

    RFS program announcements are posted below by the calendar year in which the action was posted. Announcements will include rulemakings, responses to petitions, new pathway approvals, compliance deadlines, alternative plans, and among others.

  17. 76 FR 57989 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 11-1527] Video Programming and Accessibility Advisory.... SUMMARY: This document announces the next meeting of the Video Programming Accessibility Advisory... Commission regarding video description, and the delivery of video description, access to emergency...

  18. Effects of Using an Ipod App to Manage Recreation Tasks

    ERIC Educational Resources Information Center

    Uphold, Nicole M.; Douglas, Karen H.; Loseke, Dannell L.

    2016-01-01

    A withdrawal design study evaluated the effectiveness of using constant time delay to teach six adults with a developmental disability to program and use an iPod touch® as an electronic photographic activity schedule (ePAS). The ePAS, created with the First Then Visual Schedule app, consisted of photographs of different exercises to complete…

  19. FY 2016 Grant Announcement: FY 2016 Technical Analysis and Programmatic Evaluation Support to the Chesapeake Bay Program Partnership

    EPA Pesticide Factsheets

    The U.S. Environmental Protection Agency’s Chesapeake Bay Program Office is announcing a Request for Proposals for applicants to provide the Chesapeake Bay Program partners with a proposal(s) for providing technical analysis and programmatic evaluation

  20. 76 FR 68499 - Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... local watersheds through collaborative conservation. We plan to publish a final announcement as soon as... watershed needs. Through this program, we provide Federal leadership and assistance on; Efficient use of...

  1. 77 FR 58404 - Announcing the Award of Three Single-Source Program Expansion Supplement Grants to Unaccompanied...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ...] Announcing the Award of Three Single-Source Program Expansion Supplement Grants to Unaccompanied Alien... its Unaccompanied Alien Children's Program to two organizations, Florence Crittenton Services of... unaccompanied alien children through September 30, 2012. The supplement grant will support the expansion of bed...

  2. 77 FR 58403 - Announcing the Award of 24 Single-Source Program Expansion Supplement Grants Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ...] Announcing the Award of 24 Single-Source Program Expansion Supplement Grants Under the Unaccompanied Alien... under its Unaccompanied Alien Children's (UAC) Program where grantees provide a range of custodial/residential shelter care and services for recently arrived unaccompanied alien children. SUMMARY: The...

  3. FY 2018 Grant Announcement: FY2018 support for Small Water Grant (SWG) and Innovative and Nutrient Sediment Reduction (INSR) Grant

    EPA Pesticide Factsheets

    The U.S. Environmental Protection Agency’s Chesapeake Bay Program Office is announcing a request for proposals (RFP) for supporting both the:1.Small Watershed Grants (SWG) program; and 2.Innovative Nutrient and Sediment Reduction (INSR) grants program.

  4. 76 FR 54772 - Notice of Intent To Award Affordable Care Act Funding, Funding Opportunity Announcement CDC-RFA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... applications under the Nutrition, Physical Activity, and Obesity Program. These applications have been..., Physical Activity, and Obesity Program Funding Opportunity Announcement (FOA). Award Information... based on methodology published in the Nutrition, Physical Activity, and Obesity Program CDC-RFA-DP08-805...

  5. 76 FR 34246 - Automated Commercial Environment (ACE); Announcement of National Customs Automation Program Test...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... CBP with authority to conduct limited test programs or procedures designed to evaluate planned... aspects of this test, including the design, conduct and implementation of the test, in order to determine... Environment (ACE); Announcement of National Customs Automation Program Test of Automated Procedures for In...

  6. FY 2017 Grant Announcement: FY 2017 Source Reduction Assistance Grant Program

    EPA Pesticide Factsheets

    The EPA Region 10 Pollution Prevention Program is announcing a grant competition for Source Reduction Assistance (SRA) awards. EPA Region 10 anticipates awarding approximately $95,000 in federal grant funding to support SRA agreements.

  7. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

  8. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

  9. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy Act...

  10. 77 FR 28601 - Announcement of an Opportunity for Manufacturers and Designers of Closed Circuit Escape...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... Correlation Test Program are not applicable as pre-test data for a respirator approval application. DATES: The... Performance Testing Within a Correlation Test Program Offered by the National Institute for Occupational...: Notice. SUMMARY: The purpose of this notice is to announce a Correlation Test Program offered by NIOSH...

  11. 29 CFR 793.7 - “Announcer.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS EXEMPTION OF CERTAIN RADIO AND TELEVISION STATION EMPLOYEES... introduce programs, read news announcements, present commercial messages, give station identification and time signals, and present other similar routine on-the-air material. In small stations, an announcer...

  12. FY 2018 Grant Announcement: FY2018 Support for Geospatial Analysis Support

    EPA Pesticide Factsheets

    The U.S. Environmental Protection Agency’s (EPA) Chesapeake Bay Program Office (CBPO) is announcing a Request for Proposals (RFP) for applicants to provide the Chesapeake Bay Program (CBP) partners with a proposal for providing geospatial analysis support

  13. Complementary Public Service Announcements as a Strategy for Enhancing the Impact of Health-Promoting Messages in Fictional Television Programs.

    PubMed

    Bavin, Lynda M; Owens, R Glynn

    2018-05-01

    Research suggests that health-promoting storylines in developed nations' fictional television programs can have a beneficial impact on viewers' beliefs, attitudes, intentions, or behaviors. The sizes of the effects are generally modest; however, the audience reach is substantial. Given that many fictional programs may hold the prolonged attention of millions of viewers, it is of value to examine potential strategies for enhancing the persuasive impact of their health-promoting storylines. Complementary public service announcements may be a promising strategy. This randomized experimental study (N = 310) examined the effects of viewing a complementary public service announcement after an organ donation story in an episode of Grey's Anatomy. Results indicated that the public service announcement enhanced the beneficial impact of the story on viewers' discussion behavior (about one's organ donor wishes), discussion intention, and perceived learning. This experimental study is the first to examine the effects of viewing a non-character public service announcement after a health-related storyline in a developed nation's fictional program compared to viewing the same episode of the program on its own. It is important for future research to examine whether these findings replicate for different health issues and with a nationally representative sample.

  14. 5 CFR 362.202 - Announcement, nomination, and selection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for, as well as a clear interest in and commitment to, leadership in the analysis and management of.... 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRESIDENTIAL MANAGEMENT FELLOWS PROGRAM Program Administration § 362.202 Announcement, nomination...

  15. 78 FR 37821 - Tribal Self-Governance Program, Negotiation Cooperative Agreement, Announcement Type: New-Limited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ..., Negotiation Cooperative Agreement, Announcement Type: New--Limited Competition Funding Announcement Number... accepting limited competition Negotiation Cooperative Agreement applications for the Tribal Self-Governance... the IHS Director. A Tribe should contact the respective ALN to begin the Self-Governance negotiations...

  16. 77 FR 68567 - Announcement of Funding Awards for the Continuum of Care Program for Fiscal Year (FY) 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ...In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of past funding decisions made by the Department in a competition for funding under the FY2011 Notice of Funding Availability (NOFAs) for the Homeless Assistance Grants program. This announcement contains the names of the awardees and the amounts of the awards made available by HUD in FY2011.

  17. A longitudinal comparison of consumer-directed and agency-directed personal assistance service programmes among persons with physical disabilities.

    PubMed

    Clark, Mary J; Hagglund, Kristofer J; Sherman, Ashley K

    2008-01-01

    To compare outcomes for persons who were enrolled in an agency-directed personal assistance services (PAS) programme and then changed to a consumer-directed PAS programme. A convenience sample was used for this longitudinal study. In-home interviews were conducted by a trained data collector from April 2000 to December 2001. Participants reported more satisfaction and safety with personal assistance, and fewer unmet needs after receiving consumer-directed services than after receiving agency-directed services. Other variables related to outcomes included race and ethnicity, employment, functional status, unmet needs, and the level of confidence in obtaining help if assistance is unavailable. Participants (74%) also reported high rates of unmet needs in the past month. Consumer-directed PAS enhances outcomes for many persons with disabilities. Self-reported outcomes are affected by many factors that could be addressed in PAS program development.

  18. Physician assistants and nurse practitioners in the National Health Service Corps.

    PubMed

    Pathman, Donald E; Konrad, Thomas R; Hooker, Roderick S

    2014-12-01

    This study describes the experiences of physician assistants (PAs) and nurse practitioners (NPs) in the National Health Service Corps' (NHSC) loan repayment program in 2010. In 2011, a stratified random sample of NHSC clinicians was surveyed. Data from the 148 PA and 137 NP respondents were analyzed (52.4% response rate). PAs were younger than NPs (mean age 31 versus 35 years), less often female (68% versus 91%), and more often carried educational debt over $100,000 (56% versus 24%). Both groups were serving in states familiar to them and within communities where they felt accepted. The groups were generally satisfied on most measures of work, with PAs more satisfied than NPs on some measures. The NHSC's PAs and NPs are well matched to communities and satisfied with their work. Maximizing their NHSC experiences and retention requires recognizing their differences in demographics, debt, and areas of job satisfaction.

  19. KSC-2012-4583

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. -- Inside the Space Exploration Technologies, or SpaceX, processing facility near NASA’s Kennedy Space Center in Florida, Scott Thurston, partner integration office manager with the Commercial Crew Program, talks to the media prior to an announcement from NASA Administrator Charles Bolden about new milestones in the nation’s commercial space initiatives. Bolden announced that SpaceX has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  20. Establishing a framework for a physician assistant/bioethics dual degree program.

    PubMed

    Carr, Mark F; Bergman, Brett A

    2014-01-01

    : Numerous medical schools currently offer a master of arts (MA) in bioethics dual degree for physicians. A degree in bioethics enhances the care physicians provide to patients and prepares physicians to serve on ethics committees and consult services. Additionally, they may work on institutional and public policy issues related to ethics. Several physician assistant (PA) programs currently offer a master of public health (MPH) dual degree for PAs. A degree in public health prepares PAs for leadership roles in meeting community health needs. With the success of PA/MPH dual degree programs, we argue here that a PA/bioethics dual degree would be another opportunity to advance the PA profession and consider how such a program might be implemented. The article includes the individual perspectives of the authors, one of whom completed a graduate-level certificate in bioethics concurrently with his 2-year PA program, while the other served as a bioethics program director.

  1. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA Research... NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and, after peer or scientific review using factors in the NRA, select proposals for...

  2. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA Research... NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and, after peer or scientific review using factors in the NRA, select proposals for...

  3. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA Research... NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and, after peer or scientific review using factors in the NRA, select proposals for...

  4. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA Research... NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and, after peer or scientific review using factors in the NRA, select proposals for...

  5. 75 FR 28801 - Energy Efficiency and Conservation Block Grant Program: Funding Opportunity Announcement (DE-FOA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... Conservation Block Grant Program: Funding Opportunity Announcement (DE-FOA-0000013) AGENCY: Office of Energy...-FOA-0000013) for the formula grants of the Energy Efficiency and Conservation Block Grant (EECBG... The Energy Efficiency and Conservation Block Grant (EECBG) [[Page 28802

  6. DHSEM Home

    Science.gov Websites

    Facebook YouTube logo YouTube News & Announcements New FY 18 Nonprofit Security Grant Program (NSGP ) - Applications DUE June 11, 2018 6:00pm New Press Release - Newtok Awarded HMGP Grant for Erosion Threatened Homes Hazard Mitigation Grant Program (HMGP) Funds Availability Announcement Fact Sheet - Preparing for

  7. KSC-2012-4585

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. -- Inside the Space Exploration Technologies, or SpaceX, processing facility near NASA’s Kennedy Space Center in Florida, NASA Administrator Charlie Bolden announced new milestones in the nation’s commercial space initiatives. Bolden announced that SpaceX has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  8. KSC-2012-4584

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. -- Inside the Space Exploration Technologies, or SpaceX, processing facility near NASA’s Kennedy Space Center in Florida, NASA Administrator Charlie Bolden announced new milestones in the nation’s commercial space initiatives. Bolden announced that SpaceX has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  9. KSC-2012-4586

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. -- Inside the Space Exploration Technologies, or SpaceX, processing facility near NASA’s Kennedy Space Center in Florida, NASA Administrator Charlie Bolden announced new milestones in the nation’s commercial space initiatives. Bolden announced that SpaceX has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  10. 10 CFR 603.410 - Announcement content.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Announcement content. 603.410 Section 603.410 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Competition Phase § 603.410 Announcement content. Once the contracting officer, in consultation with the program official, considers the factors described in Subpart...

  11. 10 CFR 603.410 - Announcement content.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Announcement content. 603.410 Section 603.410 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Competition Phase § 603.410 Announcement content. Once the contracting officer, in consultation with the program official, considers the factors described in Subpart...

  12. 10 CFR 603.410 - Announcement content.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Announcement content. 603.410 Section 603.410 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Competition Phase § 603.410 Announcement content. Once the contracting officer, in consultation with the program official, considers the factors described in Subpart...

  13. 10 CFR 603.410 - Announcement content.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Announcement content. 603.410 Section 603.410 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Competition Phase § 603.410 Announcement content. Once the contracting officer, in consultation with the program official, considers the factors described in Subpart...

  14. 10 CFR 603.410 - Announcement content.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Announcement content. 603.410 Section 603.410 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Competition Phase § 603.410 Announcement content. Once the contracting officer, in consultation with the program official, considers the factors described in Subpart...

  15. 77 FR 23492 - Announcement of Funding Awards; Capital Fund Safety and Security Grants; Fiscal Year 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... award recipients under the Capital Fund Safety and Security grant program. FOR FURTHER INFORMATION... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. 5636-FA-01] Announcement of Funding Awards... Public and Indian Housing, HUD. ACTION: Announcement of funding awards. SUMMARY: In accordance with...

  16. 76 FR 56461 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease... announced below concerns Emerging Infections Programs, Funding Opportunity Announcement (FOA), CK12-1202...), the Centers for Disease Control and Prevention (CDC) announces the aforementioned meeting: Time and...

  17. 75 FR 34519 - Bureau of Educational and Cultural Affairs; U.S. Professional Development Program for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    .... Professional Development Program for EducationUSA Advisers Notice: Correction to original Request for Grant..., announces a revision to the original Request for Grant Proposals (RFGP) for the U.S. Professional.... All other terms and conditions of the original announcement remain the same. Additional Information...

  18. 76 FR 14705 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: Youth Leadership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... for Grant Proposals: Youth Leadership Program With South Asia (Nepal, Sri Lanka, and the Maldives) and the Youth Leadership Program With Azerbaijan Announcement Type: New Cooperative Agreement. Funding... Bureau of Educational and Cultural Affairs announces an open competition for two Youth Leadership...

  19. 75 FR 59274 - Medicare and Medicaid Programs; Announcement of Application from Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...--(1) is expected to increase organ donations; and (2) will ensure equitable treatment of patients...] Medicare and Medicaid Programs; Announcement of Application from Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  20. 77 FR 24495 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... increase organ donations; and (2) will ensure equitable treatment of patients referred for transplants...] Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  1. 77 FR 60703 - Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... waiver--(1) is expected to increase organ donations; and (2) will ensure equitable treatment of patients...] Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for Organ... the requirement to have an agreement with its designated Organ Procurement Organization (OPO). The...

  2. 77 FR 51539 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... expected to increase organ donations; and (2) will ensure equitable treatment of patients referred for...] Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for Organ... the requirement to have an agreement with its designated Organ Procurement Organization (OPO). The...

  3. 75 FR 5599 - Medicare and Medicaid Programs; Announcement of Applications From Hospitals Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ...--(1) is expected to increase organ donations; and (2) will ensure equitable treatment of patients...] Medicare and Medicaid Programs; Announcement of Applications From Hospitals Requesting Waiver for Organ... otherwise require the hospitals to enter into an agreement with their designated Organ Procurement...

  4. 76 FR 78926 - Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... must determine that the waiver--(1) is expected to increase organ donations; and (2) will ensure...] Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for Organ... Hospital to participate in an Organ Procurement Organization (OPO) outside of its designated OPO. The...

  5. 76 FR 67192 - Administration on Children, Youth and Families Announces the Award of a Single-Source Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Administration on Children, Youth and Families Announces the Award of a Single-Source Program Expansion Supplement Grant to..., comprehensive outreach and increased capacity through technology improvements. STATUTORY AUTHORITY: Part C...

  6. 75 FR 81605 - Endocrine Disruptor Screening Program (EDSP); Announcing the Availability of a Draft for Weight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPPT-2010-0877; FRL-8858-9] Endocrine Disruptor Screening Program (EDSP); Announcing the Availability of a Draft for Weight-of-Evidence Guidance Document..., Endocrine disruptors, Screening assays, Weight-of-evidence. Dated: December 20, 2010. Stephen A. Owens...

  7. 78 FR 33853 - Announcement for the National Registry of Evidence-Based Programs and Practices (NREPP): Open...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... Practices (NREPP): Open Submission Period for Fiscal Year 2014 Background The Substance Abuse and Mental... DEPARTMENT OF HEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration (SAMHSA) Announcement for the National Registry of Evidence-Based Programs and Practices (NREPP): Open...

  8. Experience with physician assistants in a Canadian arthroplasty program.

    PubMed

    Bohm, Eric R; Dunbar, Michael; Pitman, David; Rhule, Chris; Araneta, Jose

    2010-04-01

    Recent increases in orthopedic surgical services in Canada have added further demand to an already stretched orthopedic workforce. Various initiatives have been undertaken across Canada to meet this demand. One successful model has been the use of physician assistants (PAs) within the Winnipeg Regional Health Authority (WRHA). This study documents the effect of PAs working in an arthroplasty practice from the perspective of patients and health care providers. We also describe the costs, time savings for surgeons and the effects on surgical throughput and waiting times. We calculated time savings by the use of a daily diary kept by the PAs. Surgeons', residents', nurses' and patients' opinions about PAs were recorded by use of a self administered questionnaire. We calculated costs using forgone general practitioner (GP) surgical assist fees and salary costs for PAs. We obtained information about surgical throughput and wait times from the WRHA waitlist database. In this study, PAs "saved" their supervising physician about 204 hours per year; this time can be used for other clinical, administrative or research duties. Physician assistants are regarded as important members of the health care team by surgeons, nurses, orthopedic residents and patients. When we compared the billing costs with those that would have been generated by the use of GP surgical assists, PAs were essentially cost neutral. Furthermore, they potentially freed GPs from the operating room to spend more time delivering primary care. We found that use of the double operating room model facilitated by PAs increased the surgical throughput of primary hip and knee replacements by 42%, and median wait times decreased from 44 weeks to 30 weeks compared with the preceding year. Physician assistants integrate well into the care team and can increase surgical volumes to reduce wait times in a cost-effective manner.

  9. Can Programmed or Self-Selected Physical Activity Affect Physical Fitness of Adolescents?

    PubMed Central

    Neto, Cláudio F.; Neto, Gabriel R.; Araújo, Adenilson T.; Sousa, Maria S. C.; Sousa, Juliana B. C.; Batista, Gilmário R.; Reis, Victor M. M. R.

    2014-01-01

    The aim of this study was to verify the effects of programmed and self-selected physical activities on the physical fitness of adolescents. High school adolescents, aged between 15 and 17 years, were divided into two experimental groups: a) a self-selected physical activity group (PAS) with 55 students (aged 15.7 ± 0.7 years), who performed physical activities with self-selected rhythm at the following sports: basketball, volleyball, handball, futsal and swimming; and b) a physical fitness training group (PFT) with 53 students (aged 16.0 ± 0.7 years), who performed programmed physical fitness exercises. Both types of activity were developed during 60 min classes. To assess physical fitness the PROESP-BR protocol was used. The statistical analysis was performed by repeated measures ANOVA. The measurements of pre and post-tests showed significantly different values after PFT in: 9 minute running test, medicine ball throw, horizontal jump, abdominal endurance, running speed and flexibility. After PAS differences were detected in abdominal endurance, agility, running speed and flexibility. The intervention with programmed physical activity promoted more changes in the physical abilities; however, in the self-selected program, agility was improved probably because of the practice of sports. Therefore, physical education teachers can use PFT to improve cardiorespiratory fitness and power of lower and upper limbs and PAS to improve agility of high school adolescents. PMID:25713652

  10. 77 FR 33223 - Announcement of the Publication of Funding Opportunity Announcements Under the Runaway and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... the Publication of Funding Opportunity Announcements Under the Runaway and Homeless Youth Act AGENCY... Statutory Authority: Runaway and Homeless Youth Act, 42 U.S.C. sections 5701-5752, as amended by the.... Porter, Director, Runaway and Homeless Youth Program, Family and Youth Services Bureau, 1250 Maryland Ave...

  11. 77 FR 5527 - Announcement of Funding Awards for Fiscal Year 2010 Sustainable Construction in Indian Country...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5415-FA-42] Announcement of Funding Awards for Fiscal Year 2010 Sustainable Construction in Indian Country Small Grant Program AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION: Announcement of funding...

  12. 76 FR 45223 - Notice of Funding Availability: Inviting Applications for McGovern-Dole International Food for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... Applications for McGovern-Dole International Food for Education and Child Nutrition Program Announcement Type... Service (FAS) announces it is inviting applications for the McGovern-Dole International Food for Education... program resources toward achieving two objectives: (1) Improve the literacy of school age children and (2...

  13. 2 CFR 170.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Requirements for program announcements, regulations, and application instructions. 170.200 Section 170.200 Grants and Agreements Office of Management... are subject to Transparency Act reporting requirements; and (2) That either: (i) Is issued on or after...

  14. 2 CFR 170.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Requirements for program announcements, regulations, and application instructions. 170.200 Section 170.200 Grants and Agreements Office of Management... are subject to Transparency Act reporting requirements; and (2) That either: (i) Is issued on or after...

  15. 2 CFR 170.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Requirements for program announcements, regulations, and application instructions. 170.200 Section 170.200 Grants and Agreements Office of Management... Transparency Act reporting requirements; and (2) That either: (i) Is issued on or after the effective date of...

  16. 2 CFR 170.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Requirements for program announcements, regulations, and application instructions. 170.200 Section 170.200 Grants and Agreements Office of Management... Transparency Act reporting requirements; and (2) That either: (i) Is issued on or after the effective date of...

  17. 75 FR 59272 - Medicare and Medicaid Programs; Announcement of an Application from a Hospital Requesting Waiver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... waiver--(1) is expected to increase organ donations; and (2) will ensure equitable treatment of patients...] Medicare and Medicaid Programs; Announcement of an Application from a Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  18. 78 FR 98 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... Secretary must determine that the waiver--(1) is expected to increase organ donations; and (2) will assure...] Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  19. 75 FR 43177 - Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... waiver, the Secretary must determine that the waiver--(1) is expected to increase organ donations; and (2...] Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  20. 75 FR 21337 - Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... waiver--(1) Is expected to increase organ donations; and (2) will ensure equitable treatment of patients...] Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver for Organ... require the hospital to enter into an agreement with its designated Organ Procurement Organization (OPO...

  1. NICBR Announces First Collaboration Project Awards | Poster

    Cancer.gov

    Courtesy of the NICBR Public Affairs/Community Relations Subcommittee The National Interagency Confederation for Biological Research (NICBR) announced the 2012 NICBR Collaboration Project Award (CPA) Program winners in December. The award, the first of its kind for NICBR, was adapted from the National Cancer Institute’s (NCI’s) Young Investigator Award Program. This year, the

  2. Announcement Notice (AN) 241.4 - Software | OSTI, US Dept of Energy Office

    Science.gov Websites

    of Scientific and Technical Information Skip to main content Scientific and Technical Information Program The home of the U.S. Department of Energy's Scientific and Technical Information Program ) Scientific and Technical Information (STI) products for announcement and availability. An AN includes review

  3. 77 FR 58398 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the University...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... of Boston for the Institute for Community Inclusion (ICI) in Boston, MA AGENCY: Administration on Developmental and Intellectual Disabilities (AIDD), ACF, HHS. ACTION: Announcing the award a single-source program expansion supplement to the University of Massachusetts for the Institute for Community Inclusion...

  4. 75 FR 60778 - Announcement of Funding Awards for Fiscal Year 2010 Historically Black Colleges and Universities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ..., and Grant Amount Region IV 1. Winston-Salem State University, Ms. Valerie Howard, Winston Salem State... Awards for Fiscal Year 2010 Historically Black Colleges and Universities Program AGENCY: Office of the... Historically Black Colleges and Universities Program. The purpose of this document is to announce the names...

  5. Understanding the role of physician assistants in oncology.

    PubMed

    Ross, Alicia C; Polansky, Maura N; Parker, Patricia A; Palmer, J Lynn

    2010-01-01

    To understand the deployment of physician assistants (PAs) in oncology. A recent analysis of the oncology workforce in the United States commissioned by ASCO predicted a significant shortage of providers by 2020. A descriptive study was undertaken using a Web-based questionnaire survey. Invited participants, including all PAs listed in the national PA database (n = 855) and all PAs at The University of Texas M. D. Anderson Cancer Center (Houston, TX; n = 159), were mailed letters directing them to the Web-based survey. The study produced a 30% response rate. A total of 186 PAs worked in medical oncology (the population of interest). Of the respondents, 80% were women, mean age was 36 years, average time employed as a PA was 9.5 years (6.5 years in oncology), 55% had obtained a master's degree, four had completed a postgraduate oncology program, 91% reported that direct mentorship by a supervising physician was very important in obtaining oncology-based knowledge, and 61% reported that becoming fully competent in the practice of oncology required 1 to 2 years. The majority of PAs (78.5%) worked 33 to 50 hours per week, and 56% of those reported working 41 to 50 hours per week. Three fourths (77%) wrote chemotherapy orders, most requiring physician co-signature, and 69% prescribed schedule III to V controlled substances. Additional data were gathered regarding clinical duties, research, and teaching. Oncology PAs are used in multiple medical settings, and many assume high-level responsibilities. Future research addressing function and factors that limit use of PAs may allow for improved organizational efficiency and enhancement in the delivery of health care.

  6. 29 CFR 793.7 - “Announcer.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... introduce programs, read news announcements, present commercial messages, give station identification and..., or write advertising, promotional or similar type copy. An employee who is primarily engaged in the...

  7. Recall of AIDS public service announcements and their impact on the ranking of AIDS as a national problem.

    PubMed Central

    Siska, M; Jason, J; Murdoch, P; Yang, W S; Donovan, R J

    1992-01-01

    The efficacy of two public service announcements from Phase V of the "America Responds to AIDS" (ARTA) campaign was assessed at two sites. Participants were randomly assigned to view a local news program, one with an ARTA public service announcement appearing six times and the other with no AIDS public service announcements. During telephone interviews with 907 participants 1 to 3 nights after viewing, 21% at Site A and 59% at Site B could correctly recall the ARTA public service announcements. Absolute mentions of AIDS as an important national issue increased. PMID:1609906

  8. 75 FR 60781 - Announcement of Funding Awards for Fiscal Year 2010 Tribal Colleges and Universities Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5415-N-06] Announcement of Funding... Secretary for Policy Development and Research, HUD. ACTION: Announcement of funding awards. SUMMARY: In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development (HUD) Reform Act of...

  9. Child Care Work Environments: The Relationship with Learning Environments

    ERIC Educational Resources Information Center

    Lower, Joanna K.; Cassidy, Deborah J.

    2007-01-01

    The study explores the relationship between child care program administration, organizational climate, and global quality. The recently developed Program Administration Scale (PAS; Talan & Bloom, 2004) was utilized in the study. Both program administration and organizational climate were found to be positively correlated with preschool…

  10. OHD/SRC - Collaborative Research Projects

    Science.gov Websites

    Collaborative Research Program Current Announcement Past Announcements Collaborative Research Projects General services. Collaborative Research Projects Fiscal Year 2004 Fiscal Year 2007 Fiscal Year 2008 Fiscal Year

  11. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Requirements for program announcements... on or after the effective date of this part; or (2) Has application or plan due dates after October 1... application or plan; (2) Maintain an active CCR registration with current information at all times during...

  12. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  13. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  14. 76 FR 29258 - Announcement of Funding Awards for a Second Round of Funding Under the Historically Black...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... Awards for a Second Round of Funding Under the Historically Black Colleges and Universities Program in... Universities Program. The purpose of this document is to announce the names, addresses and the amount awarded to the winners to be used to help Historically Black Colleges and Universities (HBCUs) expand their...

  15. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  16. 77 FR 9955 - Announcement of Funding Awards for the Community Challenge Planning Grant Program for Fiscal Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5500-FA-33] Announcement of Funding Awards for the Community Challenge Planning Grant Program for Fiscal Year 2011 AGENCY: Office of... Section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this...

  17. 75 FR 45149 - Announcement of Funding Awards for Healthy Homes and Lead Hazard Control Grant Programs for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... announced in a Federal Register notice published on May 22, 2009 for Lead Based Paint Hazard Control and... for the Lead Based Paint Hazard Control Grant Program under the Consolidated Appropriations Act, 2009... Tahoe, 1901 Airport Road, Suite 107, South Lake Tahoe, CA 96150, $1,500,000; State of Connecticut...

  18. Johns Hopkins University Announces Frederick CREST Classes for Fall 2016 | Poster

    Cancer.gov

    Johns Hopkins University’s (JHU) Advanced Academic Programs (AAP) division recently announced two classes that will be hosted at the Frederick Center for Research and Education in Science and Technology (CREST) this fall. According to a JHU press release, the classes are Biochemistry, which is part of the M.S. in Biotechnology program at JHU AAP, and Molecular Biology, a part of the M.S. in Bioinformatics program at JHU AAP.

  19. Structural integration in hypoxia-inducible factors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, Dalei; Potluri, Nalini; Lu, Jingping

    The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets. Transcriptionally active HIFs consist of HIF-alpha and ARNT (also called HIF-1 beta) subunits. Here we describe crystal structures for each of mouse HIF-2 alpha-ARNT and HIF-1 alpha-ARNT heterodimers in states that include bound small molecules and their hypoxia response element. A highly integrated quaternary architecture is shared by HIF-2 alpha-ARNT and HIF-1 alpha-ARNT, wherein ARNT spirals around the outside of each HIF-alpha subunit. Five distinctmore » pockets are observed that permit small-molecule binding, including PAS domain encapsulated sites and an interfacial cavity formed through subunit heterodimerization. The DNA-reading head rotates, extends and cooperates with a distal PAS domain to bind hypoxia response elements. HIF-alpha mutations linked to human cancers map to sensitive sites that establish DNA binding and the stability of PAS domains and pockets.« less

  20. Active Recovery After High-Intensity Interval-Training Does Not Attenuate Training Adaptation.

    PubMed

    Wiewelhove, Thimo; Schneider, Christoph; Schmidt, Alina; Döweling, Alexander; Meyer, Tim; Kellmann, Michael; Pfeiffer, Mark; Ferrauti, Alexander

    2018-01-01

    Objective: High-intensity interval training (HIIT) can be extremely demanding and can consequently produce high blood lactate levels. Previous studies have shown that lactate is a potent metabolic stimulus, which is important for adaptation. Active recovery (ACT) after intensive exercise, however, enhances blood lactate removal in comparison with passive recovery (PAS) and, consequently, may attenuate endurance performance improvements. Therefore, the aim of this study was to examine the influence of regular ACT on training adaptations during a HIIT mesocycle. Methods: Twenty-six well-trained male intermittent sport athletes (age: 23.5 ± 2.5 years; O 2 max: 55.36 ± 3.69 ml min kg -1 ) participated in a randomized controlled trial consisting of 4 weeks of a running-based HIIT mesocycle with a total of 12 HIIT sessions. After each training session, participants completed 15 min of either moderate jogging (ACT) or PAS. Subjects were matched to the ACT or PAS groups according to age and performance. Before the HIIT program and 1 week after the last training session, the athletes performed a progressive incremental exercise test on a motor-driven treadmill to determine O 2 max, maximum running velocity (vmax), the running velocity at which O 2 max occurs (vO 2 max), and anaerobic lactate threshold (AT). Furthermore, repeated sprint ability (RSA) were determined. Results: In the whole group the HIIT mesocycle induced significant or small to moderate changes in vmax ( p < 0.001, effect size [ES] = 0.65,), vO 2 max ( p < 0.001, ES = 0.62), and AT ( p < 0.001, ES = 0.56) compared with the values before the intervention. O 2 max and RSA remained unchanged throughout the study. In addition, no significant differences in the changes were noted in any of the parameters between ACT and PAS except for AT ( p < 0.05, ES = 0.57). Conclusion: Regular use of individualized ACT did not attenuate training adaptations during a HIIT mesocycle compared to PAS. Interestingly, we found that the ACT group obtained a significantly higher AT following the training program compared to the PAS group. This could be because ACT allows a continuation of the training at a low intensity and may activate specific adaptive mechanisms that are not triggered during PAS.

  1. Active Recovery After High-Intensity Interval-Training Does Not Attenuate Training Adaptation

    PubMed Central

    Wiewelhove, Thimo; Schneider, Christoph; Schmidt, Alina; Döweling, Alexander; Meyer, Tim; Kellmann, Michael; Pfeiffer, Mark; Ferrauti, Alexander

    2018-01-01

    Objective: High-intensity interval training (HIIT) can be extremely demanding and can consequently produce high blood lactate levels. Previous studies have shown that lactate is a potent metabolic stimulus, which is important for adaptation. Active recovery (ACT) after intensive exercise, however, enhances blood lactate removal in comparison with passive recovery (PAS) and, consequently, may attenuate endurance performance improvements. Therefore, the aim of this study was to examine the influence of regular ACT on training adaptations during a HIIT mesocycle. Methods: Twenty-six well-trained male intermittent sport athletes (age: 23.5 ± 2.5 years; O2max: 55.36 ± 3.69 ml min kg-1) participated in a randomized controlled trial consisting of 4 weeks of a running-based HIIT mesocycle with a total of 12 HIIT sessions. After each training session, participants completed 15 min of either moderate jogging (ACT) or PAS. Subjects were matched to the ACT or PAS groups according to age and performance. Before the HIIT program and 1 week after the last training session, the athletes performed a progressive incremental exercise test on a motor-driven treadmill to determine O2max, maximum running velocity (vmax), the running velocity at which O2max occurs (vO2max), and anaerobic lactate threshold (AT). Furthermore, repeated sprint ability (RSA) were determined. Results: In the whole group the HIIT mesocycle induced significant or small to moderate changes in vmax (p < 0.001, effect size [ES] = 0.65,), vO2max (p < 0.001, ES = 0.62), and AT (p < 0.001, ES = 0.56) compared with the values before the intervention. O2max and RSA remained unchanged throughout the study. In addition, no significant differences in the changes were noted in any of the parameters between ACT and PAS except for AT (p < 0.05, ES = 0.57). Conclusion: Regular use of individualized ACT did not attenuate training adaptations during a HIIT mesocycle compared to PAS. Interestingly, we found that the ACT group obtained a significantly higher AT following the training program compared to the PAS group. This could be because ACT allows a continuation of the training at a low intensity and may activate specific adaptive mechanisms that are not triggered during PAS. PMID:29720949

  2. Effect of Repeated Active Recovery During a High-Intensity Interval-Training Shock Microcycle on Markers of Fatigue.

    PubMed

    Wiewelhove, Thimo; Raeder, Christian; Meyer, Tim; Kellmann, Michael; Pfeiffer, Mark; Ferrauti, Alexander

    2016-11-01

    To investigate the effect of repeated use of active recovery during a 4-d shock microcycle with 7 high-intensity interval-training (HIT) sessions on markers of fatigue. Eight elite male junior tennis players (age 15.1 ± 1.4 y) with an international ranking between 59 and 907 (International Tennis Federation) participated in this study. After each training session, they completed 15 min of either moderate jogging (active recovery [ACT]) or passive recovery (PAS) with a crossover design, which was interrupted by a 4-mo washout period. Countermovement-jump (CMJ) height, serum concentration of creatine kinase (CK), delayed-onset muscle soreness (DOMS), and perceived recovery and stress (Short Recovery and Stress Scale) were measured 24 h before and 24 h after the training program. The HIT shock microcycle induced a large decrease in CMJ performance (ACT: effect size [ES] = -1.39, P < .05; PAS: ES = -1.42, P < .05) and perceived recovery (ACT: ES = -1.79, P < .05; PAS: ES = -2.39, P < .05), as well as a moderate to large increase in CK levels (ACT: ES = 0.76, P > .05; PAS: ES = 0.81, P >.05), DOMS (ACT: ES = 2.02, P < .05; PAS: ES = 2.17, P < .05), and perceived stress (ACT: ES = 1.98, P < .05; PAS: ES = 3.06, P < .05), compared with the values before the intervention. However, no significant recovery intervention × time interactions or meaningful differences in changes were noted in any of the markers between ACT and PAS. Repeated use of individualized ACT, consisting of 15 min of moderate jogging, after finishing each training session during an HIT shock microcycle did not affect exercise-induced fatigue.

  3. Value-added benefits and utilization of pathologists' assistants.

    PubMed

    Vitale, John; Brooks, Reed; Sovocool, Michael; Rader, W Rae

    2012-12-01

    The role of pathologists' assistants (PAs) in terms of surgical and autopsy prosection has been well established; however, the role of PAs in areas beyond surgical and autopsy pathology, such as laboratory administration and management, education, and research, is not so well understood. To determine the scope and extent of ancillary duties (value-added benefits) performed by PAs. A self-administered, electronic survey was disseminated to all members of the American Association of Pathologists' Assistants with fellowship status to analyze the ancillary duties PAs provide in laboratory administration and management, education, and research. Respondents were from 44 states and most had 6 or more years of experience in various work settings: community hospitals (50%), academic hospitals (30%), private pathology laboratories (15%), and "other" settings (5%). Most were involved in quality assurance programs (64.0%), laboratory accreditation inspections (56.2%), and a large percentage (44.4%) also had direct supervisory experience. Roughly 36% of respondents reported training residents in prosection skills in a clinical setting, while a small percentage reported teaching for-credit courses in a classroom setting (4.9%). The primary research responsibility was fresh tissue procurement for tumor banking (52.7%). Pathologists' assistants currently are involved in ancillary duties beyond surgical and autopsy prosection. Our findings indicate that PAs have a desire to become more involved in these duties, and there is opportunity for pathologists to benefit further by using PAs to the full extent of their knowledge, skills, and interests.

  4. Step by Step': A Community Based Rehabilitation Project with Disabled Children in Guyana. Bilingual Version = Pas a pas: Un project de readaptation a base communautaire pour les enfants handicapes en Guyane. Version bilingue. Notes, Comments...No. 189.

    ERIC Educational Resources Information Center

    O'Toole, Brian

    The document, in both English and French, describes a 2-year project in Guyana based on the principle of community-based rehabilitation (CBR), which stresses training local community residents as supervisors to provide training of rehabilitation workers and direct services to children with disabilities living in rural areas. The program provided…

  5. Cephalometric and three-dimensional assessment of the posterior airway space and imaging software reliability analysis before and after orthognathic surgery.

    PubMed

    Burkhard, John Patrik Matthias; Dietrich, Ariella Denise; Jacobsen, Christine; Roos, Malgorzota; Lübbers, Heinz-Theo; Obwegeser, Joachim Anton

    2014-10-01

    This study aimed to compare the reliability of three different imaging software programs for measuring the PAS and concurrently to investigate the morphological changes in oropharyngeal structures in mandibular prognathic patients before and after orthognathic surgery by using 2D and 3D analyzing technique. The study consists of 11 randomly chosen patients (8 females and 3 males) who underwent maxillomandibular treatment for correction of Class III anteroposterior mandibular prognathism at the University Hospital in Zurich. A set of standardized LCR and CBCT-scans were obtained from each subject preoperatively (T0), 3 months after surgery (T1) and 3 months to 2 years postoperatively (T2). Morphological changes in the posterior airway space (PAS) were evaluated longitudinally by two different observers with three different imaging software programs (OsiriX(®) 64-bit, Switzerland; Mimics(®), Belgium; BrainLab(®), Germany) and manually by analyzing cephalometric X-rays. A significant increase in the upper airway dimensions before and after surgery occurred in all measured cases. All other cephalometric distances showed no statistically significant alterations. Measuring the volume of the PAS showed no significant changes in all cases. All three software programs showed similar outputs in both cephalometric analysis and 3D measuring technique. A 3D design of the posterior airway seems to be far more reliable and precise phrasing of a statement of postoperative gradients than conventional radiography and is additionally higher compared to the corresponding manual method. In case of Class III mandibular prognathism treatment with bilateral split osteotomy of the mandible and simultaneous maxillary advancement, the negative effects of PAS volume decrease may be reduced and might prevent a developing OSAS. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  6. Factors Predicting Physician Assistant Faculty Intent to Leave

    ERIC Educational Resources Information Center

    Coniglio, David Martin

    2013-01-01

    An increasing demand for education of physician assistants (PAs) has resulted in rapid growth in the number of PA educational programs. Faculty for these programs may be recruited from existing programs. Understanding faculty turnover intention is important to guide faculty development and to improve faculty retention. The purpose of this research…

  7. One Hospital's Successful 20-Year Experience with Physician Assistants in Graduate Medical Education.

    ERIC Educational Resources Information Center

    Russell, John C.; Kaplowe, Joseph; Heinrich, Jeffrey

    1999-01-01

    Describes a New Britain General Hospital (Connecticut) program that uses mid-level practitioners, including physician assistants (PAs), to augment diminished staffs of residents in surgical residencies. Topics discussed include program structure, efforts to reduce the potential for PA/resident conflict, protection of residency program integrity,…

  8. U.S. announces one-year delay for visa waiver program change

    NASA Astrophysics Data System (ADS)

    The U.S. State Department has announced that it is delaying by one year a new rule affecting citizens from visa waiver program countries. The new rule, which was scheduled to go into effect on 1 October 2003, requires visitors from these countries to obtain non-immigrant visas to enter the United States if they do not have machine-readable passports. The announced delay means that this rule will now go into effect 26 October 2004 instead.The delay does not apply to five visa waiver countries—Andorra, Brunei, Liechtenstein, Luxembourg, and Slovenia—because most of the citizens of these nations already carry passports that are machine-readable.

  9. 7 CFR 1486.208 - How does an entity apply to the program?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... periodically announce that it is accepting proposals for participation in the EMP. All relevant information... announcement. CCC may request any additional information it deems necessary from any applicant in order to...

  10. An Announcement by Dan Goldin

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Daniel S. Goldin (NASA Administrator) announces the reconstruction of several NASA programs and management structural changes. The upcoming developments for Space Station Freedom, the Office of Space Science Applications (OSSA), and the field of Aeronautics are discussed.

  11. 78 FR 73143 - Negotiated Rulemaking Committee, Notice of Additional Committee Meeting-Title IV Federal Student...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ...On June 12, 2013, we announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to establish standards for programs that prepare students for gainful employment in a recognized occupation. We also announced the schedule for two sessions of committee meetings. We now announce the addition of a third session consisting of a one-day committee meeting.

  12. Eric Freed Named Deputy Director of HIV Drug Resistance Program | Poster

    Cancer.gov

    Editor’s note: The text for this article was adapted from an e-mail announcement to the Center for Cancer Research community from Robert Wiltrout, Ph.D., on September 8, 2014. Robert Wiltrout, Ph.D., director, NCI Center for Cancer Research (CCR), recently announced the appointment of Eric Freed, Ph.D., as deputy director of the HIV Drug Resistance Program (HIV DRP). Freed

  13. Johns Hopkins University Announces Frederick CREST Classes for Fall 2016 | Poster

    Cancer.gov

    Johns Hopkins University’s (JHU) Advanced Academic Programs (AAP) division recently announced two classes that will be hosted at the Frederick Center for Research and Education in Science and Technology (CREST) this fall. According to a JHU press release, the classes are Biochemistry, which is part of the M.S. in Biotechnology program at JHU AAP, and Molecular Biology, a part

  14. The Prenatal Care at School Program

    ERIC Educational Resources Information Center

    Griswold, Carol H.; Nasso, Jacqueline T.; Swider, Susan; Ellison, Brenda R.; Griswold, Daniel L.; Brooks, Marilyn

    2013-01-01

    School absenteeism and poor compliance with prenatal appointments are concerns for pregnant teens. The Prenatal Care at School (PAS) program is a new model of prenatal care involving local health care providers and school personnel to reduce the need for students to leave school for prenatal care. The program combines prenatal care and education…

  15. What is the relation between number of sessions worked and productivity of radiologists-a pilot study?

    PubMed

    Khan, Shah H M; Hedges, William P

    2016-04-01

    Increasing workloads and the current austerity measures are putting UK radiology departments under considerable stress. We need to look at the most efficient ways to manage radiology departments in order to cope with increasing demand. Consequently, a system is needed that can compare productivity between radiologists with different jobs. We measured workload in a UK radiology department and compared the productivities of consultants working different numbers of sessions, which are called programmed activities (PAs), to identify the optimal job plan structure for reporting productivity. Reporting data was gathered from electronic records for 14 consultants working different numbers of PA during the period April 2010-March 2011. These were converted into relative value unit (RVU) scores using a modified RCSI RVU system. Crude and net workloads were calculated for each consultant by dividing their total RVU score by the number of PAs they were contracted for and how many they spent reporting. The consultants reported 118,001 imaging studies. There was statistically significant variation in productivity between consultants working different numbers of PAs on χ (2) analysis (p < 0.05). Consultants working 12 PAs were more productive than consultants working 11 PAs, with net workloads of 7636 RVU/PA/year versus net 6146 RVU/PA/year, p < 0.05. Although UK consultants working 12 PAs per week are more productive than their colleagues, the reasons why are unclear. We have identified a method that can be developed further to identify efficient working practices in UK radiology departments. However, a UK-specific RVU system would make this productivity analysis more accurate.

  16. 75 FR 39953 - Modification to the Basic Center Program Funding Opportunity Announcement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    .... Announcement Type: Modification. Funding Opportunity Number: HHS-2010-ACF-ACYF-CY-0002. CFDA Number: 93.623... points. Margins less than \\1/2\\ inch: Deduction of 3 points. Font is not at least 12-point size or Times...

  17. A Users Guide for the NASA ANOPP Propeller Analysis System

    NASA Technical Reports Server (NTRS)

    Nguygen, L. Cathy; Kelly, Jeffrey J.

    1997-01-01

    The purpose of this report is to document improvements to the Propeller Analysis System of the Aircraft Noise Prediction Program (PAS-ANOPP) and to serve as a users guide. An overview of the functional modules and modifications made to the Propeller ANOPP system are described. Propeller noise predictions are made by executing a sequence of functional modules through the use of ANOPP control statements. The most commonly used ANOPP control statements are discussed with detailed examples demonstrating the use of each control statement. Originally, the Propeller Analysis System included the angle-of-attack only in the performance module. Recently, modifications have been made to also include angle-of-attack in the noise prediction module. A brief description of PAS prediction capabilities is presented which illustrate the input requirements necessary to run the code by way of ten templates. The purpose of the templates are to provide PAS users with complete examples which can be modified to serve their particular purposes. The examples include the use of different approximations in the computation of the noise and the effects of synchrophasing. Since modifications have been made to the original PAS-ANOPP, comparisons of the modified ANOPP and wind tunnel data are also included. Two appendices are attached at the end of this report which provide useful reference material. One appendix summarizes the PAS functional modules while the second provides a detailed discussion of the TABLE control statement.

  18. 75 FR 41639 - Availability of Grant Funds for Fiscal Year 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ...The National Oceanic and Atmospheric Administration publishes this notice to provide the general public with a consolidated source of program and application information related to its competitive grant and cooperative agreement award offerings for fiscal year (FY) 2011. This Omnibus notice is designed to replace the multiple Federal Register notices that traditionally advertised the availability of NOAA's discretionary funds for its various programs. It should be noted that additional program initiatives may be announced through subsequent Federal Register notices. All announcements will also be available through the Grants.gov Web site.

  19. 75 FR 16072 - Fisheries Finance Program; Final Program Notice and Announcement of Availability of Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...NMFS announces the availability of long-term direct loans made underthe Fisheries Finance Program (FFP). The FFP provides financing for the purchase of used vessels or the reconstruction of vessels (limited to reconstructions that do not add to fishing capacity); refinancing for existing debt obligations; financing or refinancing fisheries shoreside facilities or aquacultural facilities; and the purchase or refinancing of Individual Fishing Quota (IFQ) in the North Pacific. FFP loans are not issued for purposes which could contribute to over capitalization of the fishing industry.

  20. Use of psychoactive substances in prison: Results of a study in the Lyon-Corbas prison, France.

    PubMed

    Sahajian, F; Berger-Vergiat, A; Pot, E

    2017-09-01

    In prison, in 2012, according to various sources, from 4 to 56% of the European inmate population used psychoactive substances (PAS). The aim of our study was to describe PAS consumption during incarceration in the prison of Lyon-Corbas, France. A transversal descriptive study was conducted between September 23rd and September 27th 2013 among all inmates of this prison. We used an anonymous self-administered questionnaire, distributed at lunchtime and collected, the same day, at dinnertime, by the mental health service personnel. Among 785 inmates present at the time of the study in the prison of Lyon-Corbas, 710 were included and the response rate was 64.4% (95% CI [60.8-67.8]). Among 457 responding inmates, 16.4% (95% CI [13.2-20.0]) reported no PAS consumption. Among 382 consumers, 74.4% (95% CI [69.8-78.5]) used tobacco, 36.8% (95% CI [32.2-41.8]) cannabis, 30.4% (95% CI [25.9-35.1]) alcohol, 7.7% (95% CI [5.2-10.6]) heroin and 10.3% (95% CI [7.5-13.6]) cocaine. Furthermore, 15% of consumers had started PAS consumption during their incarceration. Among consumers of at least one PAS other than tobacco, cannabis and alcohol, the way of consumption was sniff for 60.0% (95% CI [48.5-70.2]) and injection for 31.0% (95% CI [21.6-42.1]). Use of several PAS at the same time and sharing sniffing and/or injection paraphernalia were other risky behaviors observed; 12% (95% CI [5.8-20.4]) of drug injectors declared using chlorine to sterilize their injection paraphernalia. Our study provides worrying data about PAS consumption in prison. The measures of prohibition do not prevent this consumption. There is even an initiation of consumption of PAS for 15% of the first-time incarcerated inmates. This finding should encourage public authorities to facilitate access of inmates to the care structures in prisons, to improve drug use prevention and care programs and to develop activities (sports, cultural, educational and vocational). Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  1. The Practitioner's Corner: Special Editorial Announcement.

    ERIC Educational Resources Information Center

    Annunziata, Joyce

    2000-01-01

    The "Journal of Personnel Evaluation in Education" announces the establishment of a new section, "The Practitioner's Corner," a section that will provide the opportunity for practitioners from many educational environments to share information about issues, controversies, and programs in personnel evaluation that reflect practice. (SLD)

  2. Information Technology Research and Education at NSF

    NASA Astrophysics Data System (ADS)

    Wink, Donald J.

    2000-11-01

    The NSF has been a leader in the development of new information technologies, including support for work in education and technology. Often, opportunities for educators are found in larger efforts. This is the case for the Information Technology Research (ITR) program. It has now been extended to education areas, as announced in NSF Publication 00-126. Links to the program announcement in multiple formats are found at http://www.nsf.gov/cgi-bin/getpub?nsf00126.

  3. Facilitating Research in Physician Assistant Programs: Creating a Student-Level Longitudinal Database.

    PubMed

    Morgan, Perri; Humeniuk, Katherine M; Everett, Christine M

    2015-09-01

    As physician assistant (PA) roles expand and diversify in the United States and around the world, there is a pressing need for research that illuminates how PAs may best be selected, educated, and used in health systems to maximize their potential contributions to health. Physician assistant education programs are well positioned to advance this research by collecting and organizing data on applicants, students, and graduates. Our PA program is creating a permanent longitudinal education database for research that contains extensive student-level data. This database will allow us to conduct research on all phases of PA education, from admission processes through the professional practice of our graduates. In this article, we describe our approach to constructing a longitudinal student-level research database and discuss the strengths and limitations of longitudinal databases for research on education and the practice of PAs. We hope to encourage other PA programs to initiate similar projects so that, in the future, data can be combined for use in multi-institutional research that can contribute to improved education for PA students across programs.

  4. Crack users show high rates of antisocial personality disorder, engagement in illegal activities and other psychosocial problems.

    PubMed

    Paim Kessler, Felix Henrique; Barbosa Terra, Mauro; Faller, Sibele; Ravy Stolf, Anderson; Carolina Peuker, Ana; Benzano, Daniela; Pechansky, Flavio

    2012-01-01

    The aim of this study was to compare three groups of Brazilian psychoactive substance (PAS) abuse patients (crack cocaine users, cocaine snorters, and non-cocaine PAS users) in terms of psychiatric comorbidities and severity of psychosocial problems. A cross-sectional, multi-center study was conducted at five Brazilian research centers. A total of 738 current PAS abusers seeking specialized treatment (outpatient and inpatient clinics) were assessed using the sixth version of the Addiction Severity Index (ASI-6): 293 patients using crack cocaine were compared with 126 using powder cocaine and 319 using non-cocaine PAS (mostly alcohol and marijuana). Psychiatric comorbidities were assessed in a smaller sample (290 cases), originating from three of the centers, using the Mini International Neuropsychiatric Interview Plus (MINI-Plus). Crack and powder cocaine users were significantly younger than non-cocaine PAS users (31.1 ± 8.1 and 32.9 ± 8.8 vs. 42.4 ± 12, respectively; p < .001). Crack users presented a higher rate of antisocial personality disorder (25%) than powder cocaine (9%) and non-cocaine PAS users (9%), even when adjusted for confounding factors (Pr = 2.6; 95% CI 1.10-6.40). According to ASI-6 summary scores, crack users presented a significantly higher rate of occupational, family, and legal problems and reported more illegal and violent activities such as burglary and theft (23%) and threatening or assaulting (32%) than non-cocaine PAS users. Our findings, combined with the recent increase observed in the prevalence of crack use in Brazil, highlight the severity of psychiatric symptoms and psychosocial problems related to this powerful drug and corroborate the already suggested association between crack/cocaine, violence, and legal problems. Treatment programs for crack users should routinely consider the possibility of associated psychiatric comorbidities, such as antisocial personality disorder, which may affect treatment outcomes. Copyright © American Academy of Addiction Psychiatry.

  5. 77 FR 7383 - Announcement of Funding Awards for the Continuum of Care Program for Fiscal Year (FY) 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ...In accordance with Section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of past funding decisions made by the Department in a competition for funding under the FY2010 Notice of Funding Availability (NOFA) for the Homeless Assistance Grants program. This announcement contains the names of the awardees and the amounts of the awards made available by HUD in 2010. A Federal Register notice on this action was not published at the time; however, the public was advised of these grant selections since they were posted on HUD's Web site. The posting contained a listing of the selected applicants, including descriptions of the projects.

  6. The physiology analysis system: an integrated approach for warehousing, management and analysis of time-series physiology data.

    PubMed

    McKenna, Thomas M; Bawa, Gagandeep; Kumar, Kamal; Reifman, Jaques

    2007-04-01

    The physiology analysis system (PAS) was developed as a resource to support the efficient warehousing, management, and analysis of physiology data, particularly, continuous time-series data that may be extensive, of variable quality, and distributed across many files. The PAS incorporates time-series data collected by many types of data-acquisition devices, and it is designed to free users from data management burdens. This Web-based system allows both discrete (attribute) and time-series (ordered) data to be manipulated, visualized, and analyzed via a client's Web browser. All processes occur on a server, so that the client does not have to download data or any application programs, and the PAS is independent of the client's computer operating system. The PAS contains a library of functions, written in different computer languages that the client can add to and use to perform specific data operations. Functions from the library are sequentially inserted into a function chain-based logical structure to construct sophisticated data operators from simple function building blocks, affording ad hoc query and analysis of time-series data. These features support advanced mining of physiology data.

  7. Sandia National Laboratories performance assessment methodology for long-term environmental programs : the history of nuclear waste management.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marietta, Melvin Gary; Anderson, D. Richard; Bonano, Evaristo J.

    2011-11-01

    Sandia National Laboratories (SNL) is the world leader in the development of the detailed science underpinning the application of a probabilistic risk assessment methodology, referred to in this report as performance assessment (PA), for (1) understanding and forecasting the long-term behavior of a radioactive waste disposal system, (2) estimating the ability of the disposal system and its various components to isolate the waste, (3) developing regulations, (4) implementing programs to estimate the safety that the system can afford to individuals and to the environment, and (5) demonstrating compliance with the attendant regulatory requirements. This report documents the evolution of themore » SNL PA methodology from inception in the mid-1970s, summarizing major SNL PA applications including: the Subseabed Disposal Project PAs for high-level radioactive waste; the Waste Isolation Pilot Plant PAs for disposal of defense transuranic waste; the Yucca Mountain Project total system PAs for deep geologic disposal of spent nuclear fuel and high-level radioactive waste; PAs for the Greater Confinement Borehole Disposal boreholes at the Nevada National Security Site; and PA evaluations for disposal of high-level wastes and Department of Energy spent nuclear fuels stored at Idaho National Laboratory. In addition, the report summarizes smaller PA programs for long-term cover systems implemented for the Monticello, Utah, mill-tailings repository; a PA for the SNL Mixed Waste Landfill in support of environmental restoration; PA support for radioactive waste management efforts in Egypt, Iraq, and Taiwan; and, most recently, PAs for analysis of alternative high-level radioactive waste disposal strategies including repositories deep borehole disposal and geologic repositories in shale and granite. Finally, this report summarizes the extension of the PA methodology for radioactive waste disposal toward development of an enhanced PA system for carbon sequestration and storage systems. These efforts have produced a generic PA methodology for the evaluation of waste management systems that has gained wide acceptance within the international community. This report documents how this methodology has been used as an effective management tool to evaluate different disposal designs and sites; inform development of regulatory requirements; identify, prioritize, and guide research aimed at reducing uncertainties for objective estimations of risk; and support safety assessments.« less

  8. 75 FR 69096 - Public Meetings of National Flood Insurance Program (NFIP) Reform Effort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2010-0065... Management Agency, DHS. ACTION: Announcement of public meetings. SUMMARY: This notice announces two public... Federal Emergency Management Agency (FEMA) believes it is important to continually update stakeholders on...

  9. 78 FR 44104 - Notice of Intent To Issue a Funding Opportunity Announcement; Technical Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Funding Opportunity Announcement; Technical Assistance AGENCY: Federal Energy Management Program, Office.... This notice also is to inform Federal agencies of the availability of technical assistance in advance.... FOR FURTHER INFORMATION CONTACT: For requests for technical assistance regarding CHP, please contact...

  10. 76 FR 58822 - Announcement of Funding Awards for Fiscal Year 2010 Transformation Initiative: Homeless Families...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5415-FA-23] Announcement of Funding Awards for Fiscal Year 2010 Transformation Initiative: Homeless Families Demonstration Small Grant Research Program AGENCY: Office of the Assistant Secretary for Policy Development, HUD. ACTION...

  11. 48 CFR 35.016 - Broad agency announcement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Scientific Review (see 6.102(d)(2)) for the acquisition of basic and applied research and that part of... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.016 Broad agency announcement. (a) General... documents, shall— (1) Describe the agency's research interest, either for an individual program requirement...

  12. 76 FR 78732 - FY 2011 Discretionary Funding Opportunity; Section 5309 Bus and Bus Facilities Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... VTCLI supports the Obama Administration's priority of supporting America's veterans and military... Living Initiative Competitive Grant Program Funds: Announcement of Project Selections. SUMMARY: The U.S. Department of Transportation's (DOT) Federal Transit Administration (FTA) announces the selection of projects...

  13. 77 FR 34972 - Announcement of Funding Awards for the McKinney-Vento HMIS Technical Assistance (HMIS TA) Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of funding decisions made by the Department in a competition for funding under the Notice of Funding Availability (NOFA) for the McKinney-Vento HMIS Technical Assistance program. This announcement contains the names of the awardees and amounts of the awards made available by HUD.

  14. 77 FR 10766 - Announcement of Funding Awards for the McKinney-Vento HMIS Technical Assistance (HMIS TA) Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ...In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of funding decisions made by the Department in a competition for funding under the Notice of Funding Availability (NOFA) for the McKinney-Vento HMIS Technical Assistance program. This announcement contains the names of the awardees and amounts of the awards made available by HUD.

  15. Choice of personal assistance services providers by medicare beneficiaries using a consumer-directed benefit: rural-urban differences.

    PubMed

    Meng, Hongdao; Friedman, Bruce; Wamsley, Brenda R; Van Nostrand, Joan F; Eggert, Gerald M

    2010-01-01

    To examine the impact of an experimental consumer-choice voucher benefit on the selection of independent and agency personal assistance services (PAS) providers among rural and urban Medicare beneficiaries with disabilities. The Medicare Primary and Consumer-Directed Care Demonstration enrolled 1,605 Medicare beneficiaries in 19 counties in New York State, West Virginia, and Ohio. A total of 839 participants were randomly assigned to receive a voucher benefit (up to $250 per month with a 20% copayment) that could be used toward PAS provided by either independent or agency workers. A bivariate probit model was used to estimate the probabilities of choosing either type of PAS provider while controlling for potential confounders. The voucher was associated with a 32.4% (P < .01) increase in the probability of choosing agency providers and a 12.5% (P= .03) increase in the likelihood of choosing independent workers. When the analysis was stratified by rural/urban status, rural voucher recipients had 36.8% higher probability of using independent workers compared to rural controls. Urban voucher recipients had 37.1% higher probability of using agency providers compared to urban controls. This study provided evidence that rural and urban Medicare beneficiaries with disabilities may have very different responses to a consumer-choice PAS voucher program. Offering a consumer-choice voucher option to rural populations holds the potential to significantly improve their access to PAS. © 2010 National Rural Health Association.

  16. Value of trainees in a radiology department. A retrospective semi-quantitative analysis.

    PubMed

    Vardhanabhuti, V; Bhatnagar, G; Brown, S; James, J; Shuen, V; Sidhu, H; Thomas, R; Fox, B

    2011-07-01

    To examine the productivity (both economic and otherwise) of trainees within a radiology department at our institution. Productivity was measured in three ways: (1) independent workload contribution, (2) impact on on-call services, and (3) impact on day-to-day practice as perceived by consultant radiologists. Data were collected using retrospective searches on computerized radiology information system (CRIS), analysis of trainees and consultant rotas, and a questionnaire to consultants and trainees. Where possible, productivity was quantified in terms of number of programmed activities (PAs). The contribution of independent work by trainees in a single week was 52.75 PAs (or 1.45 PAs per trainee per week). In addition, the on-call contribution was 23.1 PAs per week (or 0.93 PAs per trainee per week). When both trainees and consultants report independently, productivity in a single list in most cases increased and can be as much as 197%. On calculating the economic impact, this amounts to significant savings of around £1.2million per year at our institution. Based upon objectively measurable areas of service provision, the employment of trainees yields considerable economic benefit. Furthermore, based upon qualitative methods we have shown that trainees contribute positively in those areas, which are much harder to quantifiably evaluate. These are benefits in addition to fundamental requirement to train future competent radiologists. Copyright © 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  17. Physician assistants and the disclosure of medical error.

    PubMed

    Brock, Douglas M; Quella, Alicia; Lipira, Lauren; Lu, Dave W; Gallagher, Thomas H

    2014-06-01

    Evolving state law, professional societies, and national guidelines, including those of the American Medical Association and Joint Commission, recommend that patients receive transparent communication when a medical error occurs. Recommendations for error disclosure typically consist of an explanation that an error has occurred, delivery of an explicit apology, an explanation of the facts around the event, its medical ramifications and how care will be managed, and a description of how similar errors will be prevented in the future. Although error disclosure is widely endorsed in the medical and nursing literature, there is little discussion of the unique role that the physician assistant (PA) might play in these interactions. PAs are trained in the medical model and technically practice under the supervision of a physician. They are also commonly integrated into interprofessional health care teams in surgical and urgent care settings. PA practice is characterized by widely varying degrees of provider autonomy. How PAs should collaborate with physicians in sensitive error disclosure conversations with patients is unclear. With the number of practicing PAs growing rapidly in nearly all domains of medicine, their role in the error disclosure process warrants exploration. The authors call for educational societies and accrediting agencies to support policy to establish guidelines for PA disclosure of error. They encourage medical and PA researchers to explore and report best-practice disclosure roles for PAs. Finally, they recommend that PA educational programs implement trainings in disclosure skills, and hospitals and supervising physicians provide and support training for practicing PAs.

  18. Maquiladoras: Corporate America Moves South of the U.S.-Mexican Border; Encouraged by Lax Environmental Enforcement and the Prospect of a NAFTA That Fails to Integrate Internationally Binding Health, Safety and Environmental Safeguards With GATT Principles of Free Trade

    DTIC Science & Technology

    1992-09-30

    made it easy prey for industrialization and unlawful disposition of wastes from the more ’Note, The New Mexican Revolution: Economic Reform and the...at Al, A34. 7A program which allowed Mexican farm laborers to work seasonally on American farms. See Comment, Mexico’s Border Industrial Program...of Mexico, announced the first border industrialization program in 1965.8 That announcement marked the inception of the maquiladoras. Historically

  19. 75 FR 70166 - Federal Communications Commission Announces Public Meetings and Invites Comment on the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Parts 1 and 17 [WT Docket No. 08-61; WT Docket No. 03-187; DA 10-2178] Federal Communications Commission Announces Public Meetings and Invites Comment on the Environmental Effects of Its Antenna Structure Registration Program AGENCY: Federal Communications Commission...

  20. 76 FR 18225 - Request for Public Comment on Proposed Funding Opportunity Announcement for Special Initiative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Request for Public Comment on Proposed Funding Opportunity Announcement for Special Initiative Concerning the Assets... of the AFI program and Individual Development Accounts (IDAs). SUMMARY: In FY 2011, the Office of...

  1. Chandra X-ray Center

    Science.gov Websites

    NHFP/Einstein Postdoctoral Fellows Selected NASA has announced the selection of the 2018 NASA Hubble . NASA press release Read the full CXC announcement here. 4/3/2018 Accretion in Stellar Systems August 8 Calibration Database User Community Chandra Users' Committee (CUC) NASA Hubble Fellowship Program

  2. 77 FR 13026 - Energy Conservation Program: Energy Conservation Standard for Automatic Commercial Ice Makers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... written comments on these subjects. This document announces an extension of the time period for submitting... preliminary technical support document (preliminary TSD) for automatic commercial ice makers. The comment... published a Federal Register notice announcing the availability of its preliminary technical support...

  3. 78 FR 44947 - Request for Nominations for 2014 Clean Air Excellence Awards Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9838-8] Request for Nominations for 2014 Clean Air Excellence... Air Excellence Awards. SUMMARY: This notice announces the competition for the 2014 Clean Air... that the EPA's Office of Air and Radiation (OAR) announces the opening of competition for the 2014...

  4. 78 FR 16279 - HUD Healthcare Facility Documents: Notice Announcing Final Approved Documents and Assignment of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5623-N-03] HUD Healthcare Facility... notice announces that the healthcare facility documents have completed the notice and comment processes... of Healthcare Programs, Office of Housing, Department of Housing and Urban Development, 451 7th...

  5. 77 FR 16848 - Announcement of Funding Awards for the Neighborhood Stabilization Program (NSP) Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... Development. Appendix A Recipient State Amount APD Urban Planning Management, FL $500,000 LLC. Capital Access... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5499-FA-01] Announcement of Funding...) 2011 AGENCY: Office of the Assistant Secretary for Community Planning and Development, HUD. ACTION...

  6. 75 FR 48723 - Meeting Announcement: Neotropical Migratory Bird Conservation Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ...] Meeting Announcement: Neotropical Migratory Bird Conservation Advisory Group AGENCY: Fish and Wildlife... Bird Conservation Act (NMBCA) grants program (Advisory Group) will meet in person and via conference...: Recognizing the importance of conserving migratory birds, the U.S. Congress passed the NMBCA (Pub. L. 106-247...

  7. Announcing the Availability of the MIT SMASS and SMASSIR Data Sets

    NASA Technical Reports Server (NTRS)

    Binzel, R. P.; Bus, S. J.; Burbine, T. H.; Rivkin, A. S.

    2001-01-01

    We announce the release of visible and near-infrared reflectance spectroscopy measurements for nearly 2000 asteroids obtained by the MIT Small Main-Belt Asteroid Spectroscopic Survey (SMASS) program. Data are being released via http://smass.mit.edu. Additional information is contained in the original extended abstract.

  8. 77 FR 31618 - Medicaid Program; Announcement of Requirements and Registration for CMS Provider Screening...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services (CMS) [CMS-2382-N... Challenge AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS. ACTION: Notice. SUMMARY: The Centers for Medicare & Medicaid Services (CMS), is announcing the launch of the ``CMS Provider Screening...

  9. 77 FR 21811 - Announcement Regarding States Triggering “Off” in the Emergency Unemployment Compensation 2008...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Triggering ``Off'' in the Emergency Unemployment Compensation 2008 (EUC08) Program and the Federal-State.... SUMMARY: Announcement regarding states triggering ``off'' in the Emergency Unemployment Compensation 2008... average, seasonally-adjusted total unemployment rate (TUR trigger) for Texas fell below the 8.5% threshold...

  10. 77 FR 35061 - Announcement Regarding States Triggering “Off” in the Emergency Unemployment Compensation 2008...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Triggering ``Off'' in the Emergency Unemployment Compensation 2008 Program and the Federal-State Extended...: Announcement regarding states triggering ``off'' in the Emergency Unemployment Compensation 2008 (EUC08... average, seasonally adjusted total unemployment rate in Connecticut fell below the 8.0% rate required to...

  11. 78 FR 67182 - Announcement of Funding Awards for the Section 811 Project Rental Assistance Demonstration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5600-FA-28] Announcement of Funding Awards for the Section 811 Project Rental Assistance Demonstration Program Fiscal Year 2012 AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice of...

  12. 77 FR 32977 - Announcement of Funding Awards for Fiscal Year 2012 Transformation Initiative: Choice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5600-FA-17] Announcement of Funding Awards for Fiscal Year 2012 Transformation Initiative: Choice Neighborhoods Demonstration Small Research Grant Program AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION...

  13. A review and update of the NASA aircraft noise prediction program propeller analysis system

    NASA Technical Reports Server (NTRS)

    Golub, Robert A.; Nguyen, L. Cathy

    1989-01-01

    The National Aeronautics and Space Administration (NASA) Aircraft Noise Prediction Program (ANOPP) Propeller Analysis System (PAS) is a set of computational modules for predicting the aerodynamics, performance, and noise of propellers. The ANOPP PAS has the capability to predict noise levels for propeller aircraft certification and produce parametric scaling laws for the adjustment of measured data to reference conditions. A technical overview of the prediction techniques incorporated into the system is presented. The prediction system has been applied to predict the noise signature of a variety of propeller configurations including the effects of propeller angle of attack. A summary of these validation studies is discussed with emphasis being placed on the wind tunnel and flight test programs sponsored by the Federal Aviation Administration (FAA) for the Piper Cherokee Lance aircraft. A number of modifications and improvements have been made to the system and both DEC VAX and IBM-PC versions of the system have been added to the original CDC NOS version.

  14. Personal assistance services in the workplace: A literature review.

    PubMed

    Dowler, Denetta L; Solovieva, Tatiana I; Walls, Richard T

    2011-10-01

    Personal assistance services (PAS) can be valuable adjuncts to the complement of accommodations that support workers with disabilities. This literature review explored the professional literature on the use of PAS in the workplace. Bibliographic sources were used to locate relevant research studies on the use of PAS in the workplace. The studies in this review used both qualitative and quantitative methods to identify current definitions of work-related and personal care-related PAS, agency-directed versus consumer-directed PAS, long-term and short-term funding issues, development of PAS policy, and barriers to successful implementation of PAS. The studies uncovered issues related to (a) recruiting, training, and retaining personal assistants, (b) employer concerns, (c) costs and benefits of workplace PAS, (d) wages and incentives for personal assistants, and (e) sources for financing PAS as a workplace accommodation. The findings reveal the value and benefits of effective PAS on the job. PAS can lead to successful employment of people with disabilities when other accommodations cannot provide adequate workplace support. Additionally, the evolution of workplace PAS is dependent on development of realistic PAS policy and funding options. Published by Elsevier Inc.

  15. Between government policy, clinical autonomy, and market demands: a qualitative study of the impact of the Prescribing Analysis System on behavior of physicians in South Korea.

    PubMed

    Kim, Dong-Sook; Bae, Green; Yoo, Soo Yeon; Kang, Minah

    2015-09-21

    In South Korea, the Health Insurance Review and Assessment Service manages the Prescribing Analysis System (PAS) to evaluate the appropriate use of medication. To achieve the system's goal of changing prescribing behavior, it is critical to understand how physicians respond to the PAS. This study analyzes the opinions of South Korean physicians about the PAS, the way it is used, and factors affecting prescribing behavior. A qualitative, exploratory approach was used, with four focus groups of physicians from different specialties. A semi-structured guide was used to explore their opinions. Transcripts of the discussions were analyzed by the authors, who independently considered content using uniform categories. Common themes were extracted and used to gather results and draw conclusions. Physicians acknowledged some positive aspects of the PAS but, overall, had mainly negative impressions of the system, and particularly, the evaluation reports that it generates. They reported that their prescribing behavior was affected by predisposing factors, including experiential, environmental and psychological factors. Physicians reported that their negative perceptions regarding the regulations were primarily influenced by concerns about maintaining their autonomy and expertise. However, their strong resistance to these perceived infringements on their independence may be considered inconsistent in relation to their professional autonomy as there was an equally strong concern about market competition. Physicians' objections to the PAS are more likely to have been caused by deeply rooted distrust of the government agency in charge of the system. Interestingly, we found that physicians' strong resistance to perceived violations of their autonomy seems somewhat inconsistent and contradictory. While they are very positive about new information or printed materials provided by pharmaceutical representatives, they are less enthusiastic when it comes to governmental guidelines or standards. Similarly, they appear to willingly accept situations in which they believe they should comply with patients' demands as a means of surviving in a competitive market. It is notable that physicians' negative perceptions of PAS seemed to be aggravated by suspicion and distrust regarding the purpose of this program. Because of widespread beliefs in professional autonomy, market competition, and a deep-seated distrust of the system, it would be difficult for the government to persuade physicians to change their prescribing behaviors using only the PAS. Successful implementation of the PAS will not only require its improvement as a policy tool, but also the creation of a social consensus regarding the PAS.

  16. Euthanasia or physician-assisted suicide? A survey from the Netherlands.

    PubMed

    Kouwenhoven, Pauline S C; van Thiel, Ghislaine J M W; Raijmakers, Natasja J H; Rietjens, Judith A C; van der Heide, Agnes; van Delden, Johannes J M

    2014-03-01

    Legalizing euthanasia or physician-assisted suicide (PAS) is a current topic of debate in many countries. The Netherlands is the only country where legislation covers both. To study physicians' experiences and attitudes concerning the choice between euthanasia and PAS. A questionnaire including vignettes was sent to a random sample of 1955 Dutch general practitioners, elderly care physicians and medical specialists. In total, 793 physicians (41%) participated. There was no clear preference for euthanasia (36%) or PAS (34%). Two thirds of physicians thought that PAS underlines the autonomy and responsibility of the patient and considered this a reason to choose PAS. Reasons for not choosing PAS were expected practical problems. A minority (22%) discussed the possibility of PAS with their patient in case of a request for assistance in dying. Patients receiving PAS more often experienced psychosocial suffering in comparison with patients receiving euthanasia. In vignettes of patients with a request for assistance in dying due to psychosocial suffering, physicians agreed more often with the performance of PAS than with euthanasia. Dutch physicians perceive a difference between euthanasia and PAS. Although they believe PAS underlines patient autonomy and responsibility, the option of PAS is rarely discussed with the patient. The more psychosocial in nature the patient's suffering, the more physicians choose PAS. In these cases, PAS seems to fulfil physicians' preferences to emphasize patient autonomy and responsibility. Expected technical problems and unfamiliarity with PAS also play a role. Paradoxically, the choice for PAS is predominantly a physician's one.

  17. 76 FR 25734 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: Youth Leadership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... for Grant Proposals: Youth Leadership Program Announcement Type: New Cooperative Agreement. Funding... Bureau of Educational and Cultural Affairs (ECA) announces an open competition for the Youth Leadership... leadership development, and to support follow-on projects in their home communities. U.S. Embassies in the...

  18. 76 FR 67195 - Announcing the Award of a Single-Source Program Expansion Supplement Grant to the Johns Hopkins...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Announcing the... School of Public Health in Baltimore, MD, To Support the Development of a Human Services National... extend an award made to the Johns Hopkins University (JHU), Greenberg School of Public Health in...

  19. 20 CFR 633.202 - Announcement of State planning estimates and invitation to submit a grant application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Announcement of State planning estimates and invitation to submit a grant application. 633.202 Section 633.202 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR MIGRANT AND SEASONAL FARMWORKER PROGRAMS Grant Planning and Application...

  20. 75 FR 66117 - Announcement of Funding Awards for the Community Development Technical Assistance Programs Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5300-FA-18] Announcement of Funding... Assistant Secretary for Community Planning and Development, HUD. ACTION: Notice of funding awards. SUMMARY: In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act...

  1. 76 FR 9588 - Announcement of Funding Awards for the Rural Housing and Economic Development Program; Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5300-FA-04] Announcement of Funding... Assistant Secretary for Community Planning and Development, HUD. ACTION: Notice of funding awards. SUMMARY: In accordance with section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act...

  2. 77 FR 65197 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the University...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families [CFDA Number 93... of Oklahoma in Tulsa, OK AGENCY: Children's Bureau, Administration on Children, Youth and Families, Administration for Children and Families, Health and Human Services. ACTION: Announcement of the award of a...

  3. 20 CFR 615.13 - Announcement of the beginning and ending of Extended Benefit Periods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Extended Benefit Periods. 615.13 Section 615.13 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR EXTENDED BENEFITS IN THE FEDERAL-STATE UNEMPLOYMENT COMPENSATION PROGRAM § 615.13 Announcement of the beginning and ending of Extended Benefit Periods. (a) State indicators. Upon receipt of the...

  4. 20 CFR 615.13 - Announcement of the beginning and ending of Extended Benefit Periods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Extended Benefit Periods. 615.13 Section 615.13 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR EXTENDED BENEFITS IN THE FEDERAL-STATE UNEMPLOYMENT COMPENSATION PROGRAM § 615.13 Announcement of the beginning and ending of Extended Benefit Periods. (a) State indicators. Upon receipt of the...

  5. 20 CFR 615.13 - Announcement of the beginning and ending of Extended Benefit Periods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Extended Benefit Periods. 615.13 Section 615.13 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR EXTENDED BENEFITS IN THE FEDERAL-STATE UNEMPLOYMENT COMPENSATION PROGRAM § 615.13 Announcement of the beginning and ending of Extended Benefit Periods. (a) State indicators. Upon receipt of the...

  6. 76 FR 67196 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the University...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... disabilities to increase their independence, productivity, and inclusion through access to post-secondary..., Institute for Community Inclusion in Boston, MA, To Support the Think College Project AGENCY: Administration on Developmental Disabilities, ACF, HHS. ACTION: Notice announcing the award of a single-source...

  7. 40 CFR 154.25 - Public announcement of final decision whether to initiate a Special Review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Public announcement of final decision whether to initiate a Special Review. 154.25 Section 154.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS SPECIAL REVIEW PROCEDURES Procedures § 154.25 Public...

  8. 76 FR 40336 - Fisheries of the Exclusive Economic Zone Off Alaska; Prohibited Species Donation Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ...)(2), the Regional Administrator based his selection on the following criteria: 1. The number and...; selection of an authorized distributor. SUMMARY: NMFS announces the renewal of permits to SeaShare..., NMFS must announce the selection each authorized distributor in the Federal Register and issue one or...

  9. 76 FR 59152 - Announcement of Funding Awards for the Section 4 Capacity Building for Community Development and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR 5500-FA-12] Announcement of Funding Awards for the Section 4 Capacity Building for Community Development and Affordable Housing Program Fiscal Year 2011 AGENCY: Office of the Assistant Secretary for Community Planning and Development, HUD...

  10. 77 FR 48986 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In...., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

  11. 76 FR 52330 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In...., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

  12. 77 FR 7164 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In....C., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

  13. 78 FR 25743 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In... Determination of the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92-463... applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for More Information...

  14. 77 FR 31018 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, and Centers of Excellence...) and (6), Title 5 U.S.C., and the Determination of the Director, Management Analysis and Services... review, discussion, and evaluation of applications received in response to ``Member Conflict Review, PA...

  15. 78 FR 28606 - Announcement of Funding Awards for the Housing Choice Voucher Family Self-Sufficiency (HCV FSS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ...In accordance with Section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the public of funding decisions made by the Department for funding under the Fiscal Year 2012 (FY2012) Notice of Funding Availability (NOFA) for the Housing Choice Voucher Family Self-Sufficiency (HCV-FSS) program. This announcement contains the consolidated names and addresses of those award recipients selected for funding based on the funding priority categories established in the NOFA.

  16. A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts.

    PubMed

    El-Hoss, Jad; Jing, Duohui; Evans, Kathryn; Toscan, Cara; Xie, Jinhan; Lee, Hyunjoo; Taylor, Renea A; Lawrence, Mitchell G; Risbridger, Gail P; MacKenzie, Karen L; Sutton, Rosemary; Lock, Richard B

    2016-09-13

    Patient derived xenografts (PDXs) have become a vital, frequently used, component of anti-cancer drug development. PDXs can be serially passaged in vivo for years, and shared across laboratories. As a consequence, the potential for mis-identification and cross-contamination is possible, yet authentication of PDXs appears limited. We present a PDX Authentication System (PAS), by combining a commercially available OpenArray assay of single nucleotide polymorphisms (SNPs) with in-house R studio programs, to validate PDXs established in individual mice from acute lymphoblastic leukemia biopsies. The PAS is sufficiently robust to identify contamination at levels as low as 3%, similar to the gold standard of short tandem repeat (STR) profiling. We have surveyed a panel of PDXs established from 73 individual leukemia patients, and found that the PAS provided sufficient discriminatory power to identify each xenograft. The identified SNP-discrepant PDXs demonstrated distinct gene expression profiles, indicating a risk of contamination for PDXs at high passage number. The PAS also allows for the authentication of tumor cells with complex karyotypes from solid tumors including prostate cancer and Ewing's sarcoma. This study highlights the demands of authenticating PDXs for cancer research, and evaluates a reliable authentication platform that utilizes a commercially available and cost-effective system.

  17. Spanish validation of the Premorbid Adjustment Scale (PAS-S).

    PubMed

    Barajas, Ana; Ochoa, Susana; Baños, Iris; Dolz, Montse; Villalta-Gil, Victoria; Vilaplana, Miriam; Autonell, Jaume; Sánchez, Bernardo; Cervilla, Jorge A; Foix, Alexandrina; Obiols, Jordi E; Haro, Josep Maria; Usall, Judith

    2013-02-01

    The Premorbid Adjustment Scale (PAS) has been the most widely used scale to quantify premorbid status in schizophrenia, coming to be regarded as the gold standard of retrospective assessment instruments. To examine the psychometric properties of the Spanish version of the PAS (PAS-S). Retrospective study of 140 individuals experiencing a first episode of psychosis (n=77) and individuals who have schizophrenia (n=63), both adult and adolescent patients. Data were collected through a socio-demographic questionnaire and a battery of instruments which includes the following scales: PAS-S, PANSS, LSP, GAF and DAS-sv. The Cronbach's alpha was performed to assess the internal consistency of PAS-S. Pearson's correlations were performed to assess the convergent and discriminant validity. The Cronbach's alpha of the PAS-S scale was 0.85. The correlation between social PAS-S and total PAS-S was 0.85 (p<0.001); while for academic PAS-S and total PAS-S it was 0.53 (p<0.001). Significant correlations were observed between all the scores of each age period evaluated across the PAS-S scale, with a significance value less than 0.001. There was a relationship between negative symptoms and social PAS-S (0.20, p<0.05) and total PAS-S (0.22, p<0.05), but not with academic PAS-S. However, there was a correlation between academic PAS-S and general subscale of the PANSS (0.19, p<0.05). Social PAS-S was related to disability measures (DAS-sv); and academic PAS-S showed discriminant validity with most of the variables of social functioning. PAS-S did not show association with the total LSP scale (discriminant validity). The Spanish version of the Premorbid Adjustment Scale showed appropriate psychometric properties in patients experiencing a first episode of psychosis and who have a chronic evolution of the illness. Moreover, each domain of the PAS-S (social and academic premorbid functioning) showed a differential relationship to other characteristics such as psychotic symptoms, disability or social functioning after onset of illness. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Norway/United States Design Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 5. Appendix D: PAS-4

    DTIC Science & Technology

    1993-08-01

    1410 24076 16379 23793 136.50 1411 19958 23260 26715 119.46 1412 10221 48000 48120 94.06 1413 17481 55863 56872 100.81 1414 15017 59042 59608 97.91...190.6 89481 21833 85498 165.21 255 192.0 -23876 -25624 39984 320.14 1412 193.4 10221 48000 48120 94.06 1042 194.7 27808 -171359 172640 263.02 67 195.0...610 565.8 27363 -43332 47956 244.63 1412 193.4 10221 48000 48120 94.06 749 294.1 3983 -48169 48252 273.37 1144 317.1 -8945 45697 48339 70.97 207

  19. Cost of workplace accommodations for individuals with disabilities: with or without personal assistance services.

    PubMed

    Solovieva, Tatiana I; Walls, Richard T; Hendricks, Deborah J; Dowler, Denetta L

    2009-10-01

    This study compared the expense associated with use of personal assistance services (PAS) for individuals with disabilities to the expense incurred by individuals with disabilities who did not use PAS. The intent of this investigation was to assess the disability accommodation costs and benefits of PAS and non-PAS cases. The study uses 1,182 follow-up telephone surveys and 24 telephone interviews of employers who had previously contacted the Job Accommodation Network (JAN) to discuss disability-related accommodations for an employee or potential employee that were conducted from January 2004 through December 2006. The survey included 69 employers who had considered PAS. The surveys were conducted by the University of Iowa's Law, Health Policy, and Disability Center, which contacted employers who had previously contacted JAN for consultation on workplace accommodations. The interviews were conducted by the International Center for Disability Information at West Virginia University. Key findings point to the costs associated with PAS cases and with cases not involving PAS accommodations. As reported by the employers, the median "one-time cost" of accommodations (not $0) for non-PAS cases was $500. The median "one-time cost" of accommodations (not $0) for PAS cases was $1,850. When $0 cost of accommodations on PAS cases was factored in with "one-time cost" of accommodations for PAS cases, the median cost was $0. For non-PAS cases of accommodations, when $0 cost of accommodations was considered, the outcome was a median cost of $0. The annual cost for PAS accommodations was a median cost of $8,000 in comparison to $2,000 for non-PAS. The median dollar amount estimates of direct benefits were $1,600 for PAS accommodations, similar to $1,500 for non-PAS. The most frequently mentioned benefits from PAS accommodations were (a) increased productivity, (b) increased diversity, (c) retention of a valued employee, (d) improved interactions with co-workers, (e) increased overall company morale, and (f) increased overall company productivity. The findings heighten awareness of the cost and benefits aspects associated with PAS for people with disabilities. Many non-PAS accommodations cost nothing to the employer (e.g., changing the work schedule, moving the individual to another location). When dollar cost was involved, the costs for PAS accommodations were more than three times greater than non-PAS accommodations.

  20. 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

    PubMed

    Steele, Andrew J; Prentice, Archibald G; Hoffbrand, A Victor; Yogashangary, Birunthini C; Hart, Stephen M; Lowdell, Mark W; Samuel, Edward R; North, Janet M; Nacheva, Elisabeth P; Chanalaris, Anastasios; Kottaridis, Panagiotis; Cwynarski, Kate; Wickremasinghe, R Gitendra

    2009-08-06

    We studied the actions of 2-phenylacetylenesulfonamide (PAS) on B-chronic lymphocytic leukemia (CLL) cells. PAS (5-20 microM) initiated apoptosis within 24 hours, with maximal death at 48 hours asassessed by morphology, cleavage of poly(ADP-ribose) polymerase (PARP), caspase 3 activation, and annexin V staining. PAS treatment induced Bax proapoptotic conformational change, Bax movement from the cytosol to the mitochondria, and cytochrome c release, indicating that PAS induced apoptosis via the mitochondrial pathway. PAS induced approximately 3-fold up-regulation of proapoptotic Noxa protein and mRNA levels. In addition, Noxa was found unexpectedly to be bound to Bcl-2 in PAS-treated cells. PAS treatment of CLL cells failed to up-regulate p53, suggesting that PAS induced apoptosis independently of p53. Furthermore, PAS induced apoptosis in CLL isolates with p53 gene deletion in more than 97% of cells. Normal B lymphocytes were as sensitive to PAS-induced Noxa up-regulation and apoptosis as were CLL cells. However, both T lymphocytes and bone marrow hematopoietic progenitor cells were relatively resistant to PAS. Our data suggest that PAS may represent a novel class of drug that induces apoptosis in CLL cells independently of p53 status by a mechanism involving Noxa up-regulation.

  1. A comparison of consumer-directed and agency-directed personal assistance services programmes.

    PubMed

    Hagglund, Kristofer; Clark, Mary; Farmer, Janet; Sherman, Ashley

    2004-05-06

    To compare a consumer-directed personal assistance services (PAS) programme with an agency-directed PAS programme. A convenience sample was used for this cross-sectional study with one data collection point. Outcomes were compared for consumer-directed and agency-directed PAS. Hierarchical regressions were also used to determine the predictors of outcomes across PAS programmes. In-home interviews were conducted by a trained data collector from April 2000 to December 2001. Participants in the consumer-directed programme reported more choices over PAS and satisfaction with PAS. Self-reported outcomes were primarily predicted by the following variables: service arrangement, type of provider, importance of directing PAS, health status, number of personal assistants used in past 12 months, sufficient PAS hours received, and social support. Consumer-directed PAS enhances outcomes for many persons with disabilities. Self-reported outcomes are affected by many factors that could be addressed in PAS programme development.

  2. Personal Assistance Services (PAS) for individuals with disabilities: self-care at the workplace.

    PubMed

    Solovieva, Tatiana I; Walls, Richard T; Dowler, Denetta L

    2010-01-01

    The intent of this investigation was to identify current definitions, issues, and strategies related to the use of Personal Assistance Services (PAS) in the workplace. The participants were employees with disabilities who used PAS in the workplace as well as employers who participated in research studies over the past 20 years. More than 30 articles were reviewed to determine PAS definitions, use, policies, and outcomes. A comprehensive search of bibliographic resources (e.g., EBSCOhost) was conducted to identify appropriate articles. The articles revealed current definitions of workplace PAS, demonstrated an increasing need for PAS, and highlighted fiscal and societal barriers to the full implementation of PAS at work. The outcomes clarify the historical components, but also identify questions that remain. These questions concern the effectiveness of PAS, best practices for funding PAS, and the need for national and local policies to support the use of PAS for workers with disabilities.

  3. Boundary integral solutions for faults in flowing rock

    NASA Astrophysics Data System (ADS)

    Wei, Wei

    We develop new boundary-integral solutions for faulting in viscous rock and implement solutions numerically with a boundary-element computer program, called Faux_Pas. In the solutions, large permanent rock deformations near faults are treated with velocity discontinuities within linear, incompressible, creeping, viscous flows. The faults may have zero strength or a finite strength that can be a constant or varying with deformation. Large deformations are achieved by integrating step by step with the fourth-order Runge-Kutta method. With this method, the boundaries and passive markers are updated dynamically. Faux_Pas has been applied to straight and curved elementary faults, and to listric and dish compound faults, composed of two or more elementary faults, such as listric faults and dish faults, all subjected to simple shear, shortening and lengthening. It reproduces the essential geometric elements seen in seismic profiles of fault-related folds associated with listric thrust faults in the Bighorn Basin of Wyoming, with dish faults in the Appalachians in Pennsylvania, Parry Islands of Canada and San Fernando Valley, California, and with listric normal faults in the Gulf of Mexico. Faux_Pas also predicts that some of these fault-related structures will include fascinating minor folds, especially in the footwall of the fault, that have been recognized earlier but have not been known to be related to the faulting. Some of these minor folds are potential structural traps. Faux_Pas is superior in several respects to current geometric techniques of balancing profiles, such as the "fault-bend fold" construction. With Faux_Pas, both the hanging wall and footwall are deformable, the faults are mechanical features, the cross sections are automatically balanced and, most important, the solutions are based on the first principles of mechanics. With the geometric techniques, folds are drawn only in the hanging wall, the faults are simply lines, the cross sections are arbitrarily balanced and, most important, the drawings are based on unsubstantiated rules of thumb. Faux_Pas provides the first rational tool for the study of fault-related folds.

  4. 5 CFR 470.205 - Initiation of research programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...

  5. 5 CFR 470.205 - Initiation of research programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...

  6. GLOBAL CHANGE RESEARCH NEWS #23: PUBLICATION ANNOUNCEMENT - CLIMATE CHANGES IN THE UPPER GREAT LAKES REGION; A WORKSHOP REPORT

    EPA Science Inventory

    The Global Change Research Program is pleased to announce the publication of the first report from the Great Lakes Regional Assessment that is being conducted as part of the First U.S. National Assessment. The report is entitled, Climate Changes in the Upper Great Lakes Region --...

  7. 77 FR 34973 - Announcement of Funding Awards for HUD's Fiscal Year 2011-2012 Technical Assistance and Capacity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Transformation Initiative (OneCPD TA and Core Curricula) AGENCY: Office of the Assistant Secretary for Community... Transformation Initiative (OneCPD TA and Core Curricula) program. This announcement contains the names of the... Capacity Building under the Transformation Initiative (OneCPD TA and Core Curricula) was designed to...

  8. 77 FR 6573 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... and Urban Development Reform Act of 1989, this announcement notifies the public of funding decisions...)(C) of the Department of Housing and Urban Development Reform Act of 1989 (103 Stat. 1987, 42 U.S.C..., Suite 118, Cincinnati, OH 45202-1458. Legal Aid Society of Minneapolis, 430 First Lisa Cohen, 612-746...

  9. 77 FR 35062 - Announcement Regarding States Triggering “Off” in the Emergency Unemployment Compensation 2008...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Triggering ``Off'' in the Emergency Unemployment Compensation 2008 Program and the Federal-State Extended...: Announcement regarding states triggering ``off'' in the Emergency Unemployment Compensation 2008 (EUC08... unemployment rate be at least 110% of one of the rates from a comparable period in one of the three prior years...

  10. Television and contraception.

    PubMed

    Klein, L

    1986-01-01

    This article consists of excerpts from a speach made on October 19th at the 1986 annual meeting of the Association of Planned Parenthood Professionals by Dr. Luella Klein, President of the American College of Obstetricians and Gynecologists (ACOG) between 1984-85. The speaker described the reaction of US television network to the ACOG's request that the networks air a public service announcement encouraging responsible sexual behavior among the nation's young people. In 1984 the ACOG initiated a public information program aimed at reducing the high number of unwanted births among young people. The ACOG with the help of an advertising agency developed a 27-second public service announcement stressing responsible parenthood and informing young people that they could write or call for further information. A booklet, entitled "Facts," was prepared for distribution to those who inquired. It advised young people to consider postponing sexual intercourse but to use the most effective methods of contraception if they decided to be sexually active. Oral contraceptives for females and condoms for males were recommended as the most effective methods. When the 3 major television networks, i.e., the American Broadcasting Company (ABC), the National Broadcasting Company (NBC), and the Columbia Broadcasting System (CBS), were requested to carry the announcement, all 3 networks claimed the announcement was too controversial to air. These same networks do not hesitate to show blatant, irresponsible sexual behavior repeatedly during their entertainment programming, and commercials with sexual innuendos are routinely accepted for airing by the networks. In July, 1986, the ACOG called a news conference in New York City to inform the news media about the rejection of the announcement by the networks. The conference stimulated considerable interest, and the story was carried by many newspapers and by radio and television news programs. Many of the news accounts of the story contained the public service announcement itself. As a result, young people began calling and writing for the booklet. Editorials critical of the networks' handling of the ACOG request appeared in numerous publications. The author then wrote to the presidents of each network asking them to reconsider the ACOG request. The presidents of ABC and CBS flatly rejected the request, but the president of NBC agreed to meet with the ACOG to work out an acceptable announcement. The networks must be encouraged to promote a more responsible and realistic image of sexual behavior than the image currently being conveyed in television programs and ads.

  11. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas, E-mail: andreas.winkler@mpimf-heidelberg.mpg.de

    2014-03-01

    Crystal structures of two truncated variants of the transcription factor PpsR from R. sphaeroides are presented that enabled the phasing of a triple PAS domain construct. Together, these structures reveal the importance of α-helical PAS extensions for multi-PAS domain-mediated protein oligomerization and function. Per–ARNT–Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteinsmore » are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix–turn–helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsR{sub Q-PAS1}) and two (PpsR{sub N-Q-PAS1}) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsR{sub ΔHTH}) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsR{sub ΔHTH} structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that plays an important role in signal transduction.« less

  12. Problems in developing an instrument for the rapid assessment of personality status.

    PubMed

    Van Horn, E; Manley, C; Leddy, D; Cicchetti, D; Tyrer, P

    2000-06-01

    To assess the validity of a quick assessment instrument (10 minutes) for assessing personality status, the Rapid Personality Assessment Schedule (PAS-R). The PAS-R was evaluated in psychotic patients recruited in one of the centres involved in a multicentre randomised controlled trial of intensive vs standard case management (the UK700 case management trial). Patients were assessed using both a full version of the PAS (PAS-I - ICD version) and the PAS-R. The weighted kappa statistic was used to gauge the (criterion-related) validity of the PAS-R using the PAS-I as the gold standard. Both measure code personality status using a four-point rating of severity in addition to recording individual categories of personality disorder. One hundred fifty-five (77%) of 201 patients recruited were assessed with both instruments. The weighted kappa statistic was 0.31, suggesting only moderate agreement between the PAS-I and PAS-R instruments under the four-point rating format, and 0.39 for the dichotomous personality disorder/no disorder separation. The sensitivity (64%) and specificity (82%) of the PAS-R in predicting PAS-I personality disorder were as satisfactory as for other screening instruments but still somewhat disappointing, and the PAS-R had an overall diagnostic accuracy of 78%. The PAS-R is a quick and rough method of detecting personality abnormality but is not a substitute for a fuller assessment.

  13. HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues

    PubMed Central

    Hong, Lan; Jiang, Wendy; Zheng, Wei; Zeng, Su

    2011-01-01

    Para-aminosalicylic acid (PAS), an approved drug for treatment of tuberculosis, is a promising therapeutic agent for treatment of manganese (Mn)-induced parkinsonian syndromes. Lack of a quantifying method, however, has hindered the clinical evaluation of its efficacy and thereupon new drug development. This study was aimed at developing a simple and effective method to quantify PAS and its major metabolite, N-acetyl-para-aminosalicylic acid (AcPAS), in plasma, cerebrospinal fluid (CSF) and tissues. Biological samples underwent one-step protein precipitation. The supernatant was fractionated on a reversed-phase C18 column with a gradient mobile system, followed by on-line fluorescence detection. The lower limits of quantification for both PAS and AcPAS were 50 ng/ml of plasma and 17 ng/g of tissues. The intra-day and inter-day precision values did not exceed 5% and 8%, respectively, in all three matrices. The method was used to quantify PAS and AcPAS in rat plasma and brain following a single iv injection of PAS. Data showed a greater amount of PAS than AcPAS in plasma, while a greater amount of AcPAS than PAS was found in brain tissues. The method has been proven to be sensitive, reproducible, and practically useful for laboratory and clinical investigations of PAS in treatment of Mn Parkinsonism. PMID:21159459

  14. 78 FR 17628 - Child Nutrition Programs; Income Eligibility Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... DEPARTMENT OF AGRICULTURE Food and Nutrition Service Child Nutrition Programs; Income Eligibility Guidelines AGENCY: Food and Nutrition Service, USDA. ACTION: Notice SUMMARY: This Notice announces the..., Supervisory Program Analyst, School Programs Section, Child Nutrition Division, Food and Nutrition Service...

  15. 77 FR 17004 - Child Nutrition Programs-Income Eligibility Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... DEPARTMENT OF AGRICULTURE Food and Nutrition Service Child Nutrition Programs--Income Eligibility Guidelines AGENCY: Food and Nutrition Service, USDA. ACTION: Notice. SUMMARY: This Notice announces the..., Supervisory Program Analyst, School Programs Section, Child Nutrition Division, Food and Nutrition Service...

  16. 75 FR 80561 - Community Express Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... SMALL BUSINESS ADMINISTRATION Community Express Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of short-term extension and termination of the Community Express Pilot Program. SUMMARY: This notice announces the termination of the Community Express Pilot Program following a...

  17. 7 CFR 1709.216 - Evaluation criteria and weights.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... announcement. (a) Program Design. Reviewers will consider the financial viability of the applicant's revolving... less severe physical and economic challenges. (c) Program evaluation and performance measures...

  18. 7 CFR 1709.216 - Evaluation criteria and weights.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... announcement. (a) Program Design. Reviewers will consider the financial viability of the applicant's revolving... less severe physical and economic challenges. (c) Program evaluation and performance measures...

  19. 7 CFR 1709.216 - Evaluation criteria and weights.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... announcement. (a) Program Design. Reviewers will consider the financial viability of the applicant's revolving... less severe physical and economic challenges. (c) Program evaluation and performance measures...

  20. 7 CFR 1709.216 - Evaluation criteria and weights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... announcement. (a) Program Design. Reviewers will consider the financial viability of the applicant's revolving... less severe physical and economic challenges. (c) Program evaluation and performance measures...

  1. 7 CFR 1709.216 - Evaluation criteria and weights.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... announcement. (a) Program Design. Reviewers will consider the financial viability of the applicant's revolving... less severe physical and economic challenges. (c) Program evaluation and performance measures...

  2. Physician's assistants in primary care practices: delegation of tasks and physician supervision.

    PubMed

    Ekwo, E; Dusdieker, L B; Fethke, C; Daniels, M

    1979-01-01

    Little information is available on factors influencing physicians (MDs) to delegate health care tasks to physician's assistants (PAs). Information about assignment of tasks to PAs was sought from 19 MDs engaged in practice in primary care settings in Iowa. These MDs employed 28 PAs. Tasks assigned to PAs appeared to be those that MDs judged to require little or no supervision. Tasks that could be performed efficiently by other non-MD personnel were not asigned to PAs. However, PAs were observed at the practice sites to perform tasks which the MDs had indicated could be appropriately assigned to PAs, as well as some tasks that could be performed by other non-MD personnel. The MDs provided health care to 126 (13.6 percent) of the 925 patients seen by PAs for whom the sequences of patient-provider contact were recorded. In these settings, the PAs functioned with a high degree of autonomy in providing health care. These findings have implications for educators and potential employers of PAs.

  3. Eric Freed Named Deputy Director of HIV Drug Resistance Program | Poster

    Cancer.gov

    Editor’s note: The text for this article was adapted from an e-mail announcement to the Center for Cancer Research community from Robert Wiltrout, Ph.D., on September 8, 2014. Robert Wiltrout, Ph.D., director, NCI Center for Cancer Research (CCR), recently announced the appointment of Eric Freed, Ph.D., as deputy director of the HIV Drug Resistance Program (HIV DRP). Freed will join Stephen Hughes, Ph.D., director of HIV DRP, in leading this CCR program that focuses on understanding HIV replication and pathogenesis, with the goal of developing more effective strategies for treating HIV infections, and also builds on the existing strength of HIV and retrovirus research within NCI.

  4. Assessing shortfalls and complementary conservation areas for national plant biodiversity in South Korea.

    PubMed

    Choe, Hyeyeong; Thorne, James H; Huber, Patrick R; Lee, Dongkun; Quinn, James F

    2018-01-01

    Protected areas (PAs) are often considered the most important biodiversity conservation areas in national plans, but PAs often do not represent national-scale biodiversity. We evaluate the current conservation status of plant biodiversity within current existing PAs, and identify potential additional PAs for South Korea. We modeled species ranges for 2,297 plant species using Multivariate Adaptive Regression Splines and compared the level of mean range representation in South Korea's existing PAs, which comprise 5.7% of the country's mainland area, with an equal-area alternative PA strategy selected with the reserve algorithm Marxan. We also used Marxan to model two additional conservation scenarios that add lands to approach the Aichi Biodiversity Target objectives (17% of the country). Existing PAs in South Korea contain an average of 6.3% of each plant species' range, compared to 5.9% in the modeled equal-area alternative. However, existing PAs primarily represent a high percentage of the ranges for high-elevation and small range size species. The additional PAs scenario that adds lands to the existing PAs covers 14,587.55 km2, and would improve overall plant range representation to a mean of 16.8% of every species' range. The other additional PAs scenario, which selects new PAs from all lands and covers 13,197.35 km2, would improve overall plant range representation to a mean of 13.5%. Even though the additional PAs that includes existing PAs represents higher percentages of species' ranges, it is missing many biodiversity hotspots in non-mountainous areas and the additional PAs without locking in the existing PAs represent almost all species' ranges evenly, including low-elevation ones with larger ranges. Some priority conservation areas we identified are expansions of, or near, existing PAs, especially in northeastern and southern South Korea. However, lowland coastal areas and areas surrounding the capital city, Seoul, are also critical for biodiversity conservation in South Korea.

  5. Assessing shortfalls and complementary conservation areas for national plant biodiversity in South Korea

    PubMed Central

    Thorne, James H.; Huber, Patrick R.; Lee, Dongkun; Quinn, James F.

    2018-01-01

    Protected areas (PAs) are often considered the most important biodiversity conservation areas in national plans, but PAs often do not represent national-scale biodiversity. We evaluate the current conservation status of plant biodiversity within current existing PAs, and identify potential additional PAs for South Korea. We modeled species ranges for 2,297 plant species using Multivariate Adaptive Regression Splines and compared the level of mean range representation in South Korea’s existing PAs, which comprise 5.7% of the country’s mainland area, with an equal-area alternative PA strategy selected with the reserve algorithm Marxan. We also used Marxan to model two additional conservation scenarios that add lands to approach the Aichi Biodiversity Target objectives (17% of the country). Existing PAs in South Korea contain an average of 6.3% of each plant species’ range, compared to 5.9% in the modeled equal-area alternative. However, existing PAs primarily represent a high percentage of the ranges for high-elevation and small range size species. The additional PAs scenario that adds lands to the existing PAs covers 14,587.55 km2, and would improve overall plant range representation to a mean of 16.8% of every species’ range. The other additional PAs scenario, which selects new PAs from all lands and covers 13,197.35 km2, would improve overall plant range representation to a mean of 13.5%. Even though the additional PAs that includes existing PAs represents higher percentages of species’ ranges, it is missing many biodiversity hotspots in non-mountainous areas and the additional PAs without locking in the existing PAs represent almost all species’ ranges evenly, including low-elevation ones with larger ranges. Some priority conservation areas we identified are expansions of, or near, existing PAs, especially in northeastern and southern South Korea. However, lowland coastal areas and areas surrounding the capital city, Seoul, are also critical for biodiversity conservation in South Korea. PMID:29474355

  6. 76 FR 30368 - Announcement of the Publication of Funding Opportunity Announcements under the Runaway and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    .../index.html ) on 4/25/2011: Funding opportunity number Application Funding opportunity title (FON) Access... grants/open/foa/view/HHS- 2011-ACF-ACYF-CY-0166. Street Outreach Program HHS-2011-ACF-ACYF-YO-0168. http://www.acf.hhs.gov/ 6/24/2011 grants/open/foa/view/HHS- 2011-ACF-ACYF-YO-0168. [[Page 30369

  7. ACHP | News | Mrs. Laura Bush Announces Preserve America Community

    Science.gov Websites

    Sept. 15, 2003, Mobile, Alabama—Mrs. Laura Bush today announced details of two new key components of continue to build upon. Mobile is a great example of a community that is using its past to build a better recognition program included ACHP member Emily Summers; Mobile, AL, mayor Mike Dow; Secretary of the Interior

  8. 77 FR 33773 - Announcement Regarding States Triggering “On” or “Off” in the Emergency Unemployment Compensation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Triggering ``On'' or ``Off'' in the Emergency Unemployment Compensation 2008 (EUC08) Program and the Federal...: Notice. SUMMARY: Announcement regarding states triggering ``on'' or ``off'' in the Emergency Unemployment... unemployment rate be at least 110% of one of the rates from a comparable prior period in one of the three prior...

  9. Protected areas facilitate species’ range expansions

    PubMed Central

    Thomas, Chris D.; Gillingham, Phillipa K.; Bradbury, Richard B.; Roy, David B.; Anderson, Barbara J.; Baxter, John M.; Bourn, Nigel A. D.; Crick, Humphrey Q. P.; Findon, Richard A.; Fox, Richard; Hodgson, Jenny A.; Holt, Alison R.; Morecroft, Mike D.; O’Hanlon, Nina J.; Oliver, Tom H.; Pearce-Higgins, James W.; Procter, Deborah A.; Thomas, Jeremy A.; Walker, Kevin J.; Walmsley, Clive A.; Wilson, Robert J.; Hill, Jane K.

    2012-01-01

    The benefits of protected areas (PAs) for biodiversity have been questioned in the context of climate change because PAs are static, whereas the distributions of species are dynamic. Current PAs may, however, continue to be important if they provide suitable locations for species to colonize at their leading-edge range boundaries, thereby enabling spread into new regions. Here, we present an empirical assessment of the role of PAs as targets for colonization during recent range expansions. Records from intensive surveys revealed that seven bird and butterfly species have colonized PAs 4.2 (median) times more frequently than expected from the availability of PAs in the landscapes colonized. Records of an additional 256 invertebrate species with less-intensive surveys supported these findings and showed that 98% of species are disproportionately associated with PAs in newly colonized parts of their ranges. Although colonizing species favor PAs in general, species vary greatly in their reliance on PAs, reflecting differences in the dependence of individual species on particular habitats and other conditions that are available only in PAs. These findings highlight the importance of current PAs for facilitating range expansions and show that a small subset of the landscape receives a high proportion of colonizations by range-expanding species. PMID:22893689

  10. Peptide-incorporated 3D porous alginate scaffolds with enhanced osteogenesis for bone tissue engineering.

    PubMed

    Luo, Zuyuan; Yang, Yue; Deng, Yi; Sun, Yuhua; Yang, Hongtao; Wei, Shicheng

    2016-07-01

    Good bioactivity and osteogenesis of three-dimensional porous alginate scaffolds (PAS) are critical for bone tissue engineering. In this work, alginate and bone-forming peptide-1 (BFP-1), derived from bone morphogenetic protein-7 (BMP-7), have been combined together (without carbodiimide chemistry treatment) to develop peptide-incorporated PAS (p-PAS) for promoting bone repairing ability. The mechanical properties and SEM images show no difference between pure PAS and p-PAS. The release kinetics of the labeled peptide with 6-carboxy tetramethyl rhodamine from the PAS matrix suggests that the peptide is released in a relatively sustained manner. In the cell experiment, p-PAS show higher cell adhesion, spreading, proliferation and alkaline phosphatase (ALP) activity than the pristine PAS group, indicating that the BFP-1 released from p-PAS could significantly promote the aggregation and differentiation of osteoblasts, especially at 10μg/mL of trapped peptide concentration (p-PAS-10). Furthermore, p-PAS-10 was implanted into Beagle calvarial defects and bone regeneration was analyzed after 4 weeks. New bone formation was assessed by calcein and Masson's trichrome staining. The data reveal that p-PAS group exhibits significantly enhanced oseto-regenerative capability in vivo. The peptide-modified PAS with promoted bioactivity and osteogenic differentiation in vitro as well as bone formation ability in vivo could be promising tissue engineering materials for repairing and regeneration of bone defects. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Schizotypal Perceptual Aberrations of Time: Correlation between Score, Behavior and Brain Activity

    PubMed Central

    Arzy, Shahar; Mohr, Christine; Molnar-Szakacs, Istvan; Blanke, Olaf

    2011-01-01

    A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances – including schizophrenia, schizotypal personality disorder and schizotypy. We have previously found the classical Perceptual Aberration Scale (PAS) scores, related to body and space, to be positively correlated with both behavior and temporo-parietal activation in healthy participants performing a task involving self-projection in space. However, not much is known about the relationship between temporal perceptual aberration, behavior and brain activity. To this aim, we composed a temporal Perceptual Aberration Scale (tPAS) similar to the traditional PAS. Testing on 170 participants suggested similar performance for PAS and tPAS. We then correlated tPAS and PAS scores to participants' performance and neural activity in a task of self-projection in time. tPAS scores correlated positively with reaction times across task conditions, as did PAS scores. Evoked potential mapping and electrical neuroimaging showed self-projection in time to recruit a network of brain regions at the left anterior temporal cortex, right temporo-parietal junction, and occipito-temporal cortex, and duration of activation in this network positively correlated with tPAS and PAS scores. These data demonstrate that schizotypal perceptual aberrations of both time and space, as reflected by tPAS and PAS scores, are positively correlated with performance and brain activation during self-projection in time in healthy individuals along the schizophrenia spectrum. PMID:21267456

  12. 76 FR 68243 - Youth Leadership Program: TechGirls

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... DEPARTMENT OF STATE [Public Notice: 7671] Youth Leadership Program: TechGirls Overview Information Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: Youth Leadership Program... Cultural Affairs (ECA) announces an open competition for the new Youth Leadership Program ``TechGirls...

  13. 75 FR 33573 - Rural Housing Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... Housing Program (GRRHP) Demonstration Program for Fiscal Year 2010; Correction AGENCY: Rural Housing... in the Federal Register of May 10, 2010, announcing the implementation of a demonstration program under the section 538 Guaranteed Rural Rental Housing Program (GRHHP) for Fiscal Year 2010. A correction...

  14. 7 CFR 1493.230 - Eligible transactions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.230 Eligible transactions. (a) Program announcements. From time to time CCC... markets, the maximum amount, in U.S. dollars, of guarantee exposure that CCC will undertake, and may...

  15. 7 CFR 1493.230 - Eligible transactions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.230 Eligible transactions. (a) Program announcements. From time to time CCC... markets, the maximum amount, in U.S. dollars, of guarantee exposure that CCC will undertake, and may...

  16. 7 CFR 1493.230 - Eligible transactions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.230 Eligible transactions. (a) Program announcements. From time to time CCC... markets, the maximum amount, in U.S. dollars, of guarantee exposure that CCC will undertake, and may...

  17. 75 FR 52956 - Funding Opportunity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ...; and Family Caregiver support services under Part C of the OAA. The goal of these programs is to... Programs; and Part C: Grants for the Native American Caregiver Support Program. Announcement Type: This is... Native Hawaiian Programs; and Part C: Grants for the Native American Caregiver Support Program. Current...

  18. 78 FR 68853 - International Medical Device Regulators Forum; Medical Device Single Audit Program International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ...] International Medical Device Regulators Forum; Medical Device Single Audit Program International Coalition Pilot... Drug Administration (FDA) is announcing participation in the Medical Device Single Audit Program International Coalition Pilot Program. The Medical Device Single Audit Program (MDSAP) was designed and...

  19. 75 FR 32480 - Funding Opportunity: Affordable Care Act Medicare Beneficiary Outreach and Assistance Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... Care Act Medicare Beneficiary Outreach and Assistance Program Funding for Title VI Native American Programs Purpose of Notice: Availability of funding opportunity announcement. Funding Opportunity Title/Program Name: Affordable Care Act Medicare Beneficiary Outreach and Assistance Program Funding for Title...

  20. Programmable Logic Device (PLD) Design Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

    NASA Technical Reports Server (NTRS)

    Shalkhauser, Mary Jo W.

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. At the conclusion of the development, the software and hardware description language (HDL) code was delivered to JSC for their use in their iPAS test bed to get hands-on experience with the STRS standard, and for development of their own STRS Waveforms on the now STRS compliant platform.The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe the design of the HDL code for the FPGA portion of the iPAS STRS Radio particularly the design of the FPGA wrapper and the test waveform.

  1. Medicaid.gov

    MedlinePlus

    ... Monitoring Review Plans Program Integrity National Correct Coding Initiative Affordable Care Act Program Integrity Provisions Cost Sharing ... to Care Living Well Quality of Care Improvement Initiatives Medicaid Managed Care Performance Measurement Releases & Announcements Enrollment ...

  2. Medicaid Benefits

    MedlinePlus

    ... Monitoring Review Plans Program Integrity National Correct Coding Initiative Affordable Care Act Program Integrity Provisions Cost Sharing ... to Care Living Well Quality of Care Improvement Initiatives Medicaid Managed Care Performance Measurement Releases & Announcements Enrollment ...

  3. A Database Management System Application for the Graduate Programs Office of the School of Systems and Logistics. Volume 2. Technical Reference Manual

    DTIC Science & Technology

    1988-09-01

    CIT C 15 Name of local city. InCSrATE C 2 Name of local state as tw letter abbreviatiom. SIC ZIP C 10 Loa ZIP code. Five or nine digits . InC_ PHKtE C 15...record: 10 Database Dictimary for C: \\ BASE\\PAS1E.MF Field Nane Type Width Decimal Coments PMSCODE C 2 Third and fourth digits of PAS code. ON C 3...Version: 3.01 Date: 09/01/88 Time: 21:34 Report Libary : C: ASE\\GPO.RP1 Date: 08/28/88 Time: 11:32 PRMNT OFTICNS CflRL-PRINrM Nmber of copies: 1 Starting

  4. Impact of College-Administered Quality Practice Assessments: A Longitudinal Evaluation of Repeat Peer Assessments of Continuing Competence in Physiotherapists

    PubMed Central

    O'Donovan, Mary Jane; Campbell, Fiona

    2015-01-01

    ABSTRACT Purpose: The College of Physiotherapists of Ontario (CPO) developed its peer practice assessment (PA) process under statutory requirements for quality assurance. Each year, a small percentage of physiotherapists, most selected at random, undergo PA. To shed light on continuing competence, we report outcomes from physiotherapists who have had two PAs. Methods: Records were extracted for physiotherapists with two unrelated PAs. Demographic features, peer assessors' scores, and consequent outcome decisions were examined. Outcomes were examined cross-sectionally (vs. other PAs in the same time period) and longitudinally (within cohort). Results: Between 2004 and 2012, 117 Ontario physiotherapists underwent two unrelated PAs, typically 5–7 years apart. This cohort was representative of Ontario physiotherapists in terms of sex ratios, education, and years in practice. At the first PA (PA1), this cohort's outcomes were similar to those of other physiotherapists; at the second PA (PA2), they were better than others undergoing PA1 in the same period (p=0.02). The cohort's outcomes were better at PA2 than at PA1 (p<0.001). Conclusions: Physiotherapists are likely to meet professional standards in a repeat PA 5–7 years after an initial one. Additional research is required to identify risk factors for not meeting standards. The findings provide empirical evidence to guide ongoing development of the CPO's quality management program. PMID:25931670

  5. Protected area coverage of threatened vertebrates and ecoregions in Peru: Comparison of communal, private and state reserves.

    PubMed

    Shanee, Sam; Shanee, Noga; Monteferri, Bruno; Allgas, Nestor; Alarcon Pardo, Alejandro; Horwich, Robert H

    2017-11-01

    Protected areas (PAs) are a conservation mainstay and arguably the most effective conservation strategy for species protection. As a 'megadiverse' country, Peru is a priority for conservation actions. Peruvian legislation allows for the creation of state PAs and private/communal PAs. Using publicly available species distribution and protected area data sets we evaluated the coverage of Threatened terrestrial vertebrate species distributions and ecoregions provided by both kinds of PA in Peru. Peru's state PA system covers 217,879 km 2 and private/communal PAs cover 16,588 km 2 . Of the 462 species of Threatened and Data Deficient species we evaluated, 75% had distributions that overlapped with at least one PA but only 53% had ≥10% of their distributions within PAs, with inclusion much reduced at higher coverage targets. Of the species we evaluated, 118 species are only found in national PAs and 29 species only found in private/communal PAs. Of the 17 terrestrial ecoregions found in Peru all are represented in PAs; the national PA system included coverage of 16 and private/communal PAs protect 13. One ecoregion is only protected in private/communal PAs, whereas four are only covered in national PAs. Our results show the important role private/communal PAs can play in the protection of ecological diversity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. NASA and X PRIZE Announce Winners of Lunar Lander Challenge

    NASA Image and Video Library

    2009-11-05

    NASA and the X PRIZE Foundation announced the winners of the Northrop Grumman Lunar Lander Challenge at an awards ceremony at the Rayburn House Office Building, Thursday, Nov. 5, 2009 in Washington, DC. From left to right, George Nield, Associate Administrator of Commercial Space Transportation, FAA; Charles Bolden, NASA Administrator; Doug Comstock, Director, Innovative Partnerships Program, NASA; David Masten, CEO, Masten Space Systems; Phil Eaton, VP, Operations, Armadillo Aerospace; U.S. Rep. Ralph Hall (R-TX); Peter Diamandis, Chairman and CEO, X PRIZE Foundation and Mitch Waldman, VP, Advanced Programs & Technology, Northrop Grumman. Photo Credit: (NASA/Carla Cioffi)

  7. Moebius Syndrome Foundation

    MedlinePlus

    ... to announce the opening for an Events & Program Manager. Below is the job description. Please no phone ... If you have questions, email us. Events & Program Manager Deadline to Apply: October 30, 2017 The Events & ...

  8. 48 CFR 15.602 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., Small Business Innovation Research topics, Small Business Technology Transfer Research topics, Program Research and Development Announcements, or any other Government-initiated solicitation or program. When the new and innovative ideas do not fall under topic areas publicized under those programs or techniques...

  9. 48 CFR 15.602 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Small Business Innovation Research topics, Small Business Technology Transfer Research topics, Program Research and Development Announcements, or any other Government-initiated solicitation or program. When the new and innovative ideas do not fall under topic areas publicized under those programs or techniques...

  10. 48 CFR 15.602 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Small Business Innovation Research topics, Small Business Technology Transfer Research topics, Program Research and Development Announcements, or any other Government-initiated solicitation or program. When the new and innovative ideas do not fall under topic areas publicized under those programs or techniques...

  11. Middle East Studies Teacher Training Program. Final Report.

    ERIC Educational Resources Information Center

    Sefein, Naim A.

    This guide presents a teacher training program in Middle Eastern studies and procedures for program implementation. Details concerning program announcement, participant selection, and travel accommodations are included. Participants attended an orientation and registration workshop and an intensive academic workshop before flying to Egypt for the…

  12. Can I help you? A qualitative study of pharmacist and pharmacy assistant views on the role of pharmacy assistants in New Zealand.

    PubMed

    Sheridan, Janie; Kelly, Fiona; Basheer, Mariam; Jan, Reem; Lee, Alice

    2011-08-01

    To begin to explore the role of PAs more fully in a New Zealand context, through semi-structured interviews with PAs and pharmacists. Semi-structured, qualitative interviews with a convenience sample of pairs of PAs and pharmacists working in a pharmacy together. Pharmacists and PAs both described important roles for PAs. The PAs tended to see themselves as the first point of contact for customers, and that they fulfilled an important healthcare role for the public. Pharmacists agreed that they were the first point of contact yet viewed this more as a gatekeeper role to the pharmacist. Views were also expressed about the difference between PAs and other retail employees. Pharmacists and PAs noted that the 'public' expected PAs to have a basic knowledge of non-prescription medicines and their uses. PAs described difficulties when requesting personal information from customers or asking essential questions where the customer had made a specific product request. Being able to know when to refer to the pharmacist was seen as a key role. Despite being able to describe a number of roles for PAs, these were highly variable. The lack of mandatory training and a clearly articulated role for PAs in New Zealand meant that in some cases PAs might be seen as little more than general retail assistants--a view not in line with their actual roles and practices. Attention to these issues may well help to resolve this, as will public education about the PA's role. © 2011 The Authors. IJPP © 2011 Royal Pharmaceutical Society.

  13. Effect of molecular weight profile of sorghum proanthocyanidins on resistant starch formation.

    PubMed

    Barros, Frederico; Awika, Joseph; Rooney, Lloyd W

    2014-04-01

    There is a growing interest to increase resistant starch (RS) in foods through natural modification of starch. Sorghum tannins (proanthocyanidins, PAs) were recently reported to interact with starch, increasing RS. However, there is no information about how the molecular weight profile of PAs affects RS formation. This study investigated how different-molecular-weight PAs from sorghum affected RS formation in different starch models. The levels of RS were higher (331-437 mg g(-1)) when high-amylose starch was cooked with phenolic extracts containing mostly high-molecular-weight PAs compared with extracts containing lower-molecular-weight PAs or monomeric catechin (249-285 mg g(-1)). In general, binding capacity of PAs with amylose increased proportionally with molecular weight. For example, the percentage of PAs bound to amylose increased from 45% (PAs with degree of polymerization (DP) = 6) to 94% (polymeric PAs, DP > 10). The results demonstrate that molecular weight of the PAs directly affects their interaction with starch: the higher the molecular weight, the stronger the binding to amylose and the higher the RS formation. Polymeric PAs from sorghum can naturally modify starch by interacting strongly with amylose and are thus most suitable to produce foods with higher RS. © 2013 Society of Chemical Industry.

  14. Pedunculated Pulmonary Artery Sarcoma Suggested by Transthoracic Echocardiography.

    PubMed

    Wang, Xiaobing; Ren, Weidong; Yang, Jun

    2016-04-01

    Pulmonary artery sarcoma (PAS) is an extremely rare malignancy. It is usually found after it grows large enough to occupy almost the entire lumen of the pulmonary artery and causes serious clinical symptoms. Thus, it is usually difficult to distinguish PAS from pulmonary thromboembolism based on imaging examinations. Few case reports had shown the attachment of PAS to pulmonary artery, a key characteristic for diagnosis, and differential diagnosis of PAS. In this case, we found a PAS, which did not cause local obstruction and some tumor emboli, which obstructed the branches of the pulmonary arteries and caused pulmonary hypertension and clinical symptoms. Transthoracic echocardiography (TTE) revealed a part of the tumor attached to the intima of the main pulmonary artery with a peduncle and had obvious mobility, which was suggestive of PAS and differentiated it from the pulmonary thromboembolism. To our knowledge, this is the first case report of a pedunculated PAS suggested by TTE. Combined with pulmonary artery computed tomography angiography, the diagnosis of PAS is strongly suggested before the operation. This case indicates that TTE could reveal the attachment and mobility of PAS in the main pulmonary and may provide useful information for the diagnosis and differential diagnosis of PAS, especially a pedunculated PAS. © 2015, Wiley Periodicals, Inc.

  15. Are satisfaction with and self-management of personal assistance services associated with the life satisfaction of persons with physical disabilities?

    PubMed

    Fleming-Castaldy, Rita P

    2011-01-01

    To examine the relationships between satisfaction with and self-management of personal assistance services (PAS) and the quality of life (QoL) of persons with disabilities. To test the postulate that consumer-directed PAS can fulfil the human need for control and contribute to a satisfactory life. A survey compared the perspectives of persons using consumer-directed PAS versus those using agency-directed. A Personal Data Form obtained demographics and PAS characteristics. The Quality of Life Inventory measured life satisfaction. A PAS questionnaire measured perceptions about the management of, desire for control of, and satisfaction with PAS. Data were analysed using SPSS®- 14. Significant relationships were found between QoL and satisfaction with PAS (p < 0.001) and between perceived control of PAS and satisfaction with PAS (p < 0.001). Significant group differences were also found. Consumer-directed participants reported higher satisfaction with their PAS (p < 0.01), greater control over services (p < 0.001) and greater QoL than agency-directed participants, (p = 0.001). The relationships found between self-management, PAS satisfaction, and QoL support the value of consumer-directed programmes. Rehabilitation professionals can use this knowledge to develop, implement and research practises that enable self-management.

  16. The Impact of Advanced Placement Incentive Programs. Education Policy Brief. Volume 8, Number 1, Winter 2010

    ERIC Educational Resources Information Center

    Holstead, Michael S.; Spradlin, Terry E.; McGillivray, Margaret E.; Burroughs, Nathan

    2010-01-01

    In December of 2009, Indiana Governor Mitch Daniels announced that the latest state revenue forecasts predict that the state of Indiana will spend $1.8 billion more than it receives in tax revenue collections through July 2011. Therefore, Governor Daniels announced that he will cut at least $300 million from K-12 education spending in the next…

  17. Maternal, Infant, and Early Childhood Home Visiting Program (MIECHV): Building Health and Early Development with the Pediatric Family-Centered Medical Home

    ERIC Educational Resources Information Center

    Willis, David W.

    2013-01-01

    President Obama announced his Early Learning Agenda during his Second Inaugural Address. This announcement has galvanized a special focus on early childhood policy and practices, for the prenatal to 5-year-old period, to improve educational outcomes for America's youth. The emergent science of early childhood development places an emphasis on…

  18. Racism, Power, and Place: A Critical Discourse Analysis of Online Commentary Associated with the Establishment of Culturally-Themed Housing for Black Men

    ERIC Educational Resources Information Center

    Patton, Lori D.; Sharp, Sacha; Sánchez, Berenice

    2017-01-01

    A critical discourse analysis of comments written in response to an online article related to the University of Connecticut's announcement about the ScHOLA2RS House, a culturally-themed residential program to retain and support African American male students is presented. Following this announcement, articles were published in various online media…

  19. 2016 Targeted AirShed Grant Program - Closed Announcement FY 2016

    EPA Pesticide Factsheets

    Targeted Air Shed Grant Program proposal for FY 2016. The overall goal of the program is to reduce air pollution in the Nation’s areas with the highest levels of ozone and PM2.5 ambient air concentrations.

  20. 2015 Targeted AirShed Grant Program Grant - Closed Announcement FY 2015

    EPA Pesticide Factsheets

    Targeted Air Shed Grant Program proposal for FY 2015. The overall goal of the program is to reduce air pollution in the Nation’s areas with the highest levels of ozone and PM2.5 ambient air concentrations.

  1. 75 FR 6131 - Proposed Processed Raspberry Promotion, Research, and Information Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... promotion, research, and information program for processed raspberries. The proposed program, Processed... be exempt from the assessment. The proposed program would be implemented under the Commodity... implementation of the program prior to it going into effect. In addition, USDA is announcing that the referendum...

  2. 75 FR 39323 - Amendment to the Biometric Visa Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... DEPARTMENT OF STATE [Public Notice: 7047] Amendment to the Biometric Visa Program AGENCY: Department of State. ACTION: Notice of Amendment to the Biometric Visa Program. This public notice announces an amendment to the Biometric Visa Program. Section 303 of the Enhanced Border Security and Visa...

  3. 76 FR 2686 - Video Programming and Emergency Access Advisory Committee; Announcement of Establishment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-2320] Video Programming and Emergency Access Advisory... appointment of members of the Video Programming and Emergency Access Advisory Committee (``Committee'' or... change of the Committee's popular name to the Video Programming Accessibility Advisory Committee (``VPAAC...

  4. U.S. Visa Waiver Program Changes

    NASA Astrophysics Data System (ADS)

    The U.S. State Department has just announced that a change to a new rule affecting citizens from visa waiver program countries. The rule, scheduled to go into effect on 1 October 2003, requires visitors from these countries to obtain non-immigrant visas to enter the United States if they do not have machine-readable passports. The change announced is that a visa waiver country can petition the U.S. government to delay the rule by one year. The State Department recommends that citizens of visa waiver program countries who are contemplating visiting the United States, and do not have machine-readable passports, contact the nearest U.S. embassy or consulate to find out if implementation of the rule has been temporarily waived for their countries.

  5. Paired associative stimulation modulates corticomotor excitability in chronic stroke: A preliminary investigation.

    PubMed

    Palmer, Jacqueline A; Wolf, Steven L; Borich, Michael R

    2018-01-01

    Paired associative stimulation (PAS) combining repeated pairing of electrical stimulation of a peripheral nerve with transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) can induce neuroplastic adaptations in the human brain and enhance motor learning in neurologically-intact individuals. However, the extent to which PAS is an effective technique for inducing associative plasticity and improving motor function in individuals post-stroke is unclear. The objective of this pilot study was to investigate the effects of a single session of PAS to modulate corticomotor excitability and motor skill performance in individuals post-stroke. Seven individuals with chronic stroke completed two separate visits separated by at least one week. We assessed general corticomotor excitability, intracortical network activity and behavioral outcomes prior to and at three time points following PAS and compared these outcomes to those following a sham PAS condition (PASSHAM). Following PAS, we found increased general corticomotor excitability but no significant difference in behavioral measures between PAS conditions. There was a relationship between PAS-induced corticomotor excitability increase and enhanced motor skill performance across post-PAS testing time points. These results provide preliminary evidence for the potential of PAS to increase corticomotor excitability that could favorably impact motor skill performance in chronic individuals post-stroke and are an important first step for future studies investigating the clinical application and behavioral relevance of PAS interventions in post stroke patient populations.

  6. 75 FR 39033 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Patient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Care Act (PPACA), Emerging Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity... Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement FOA CI10...

  7. Determinants of Oregon hospice chaplains' views on physician-assisted suicide.

    PubMed

    Goy, Elizabeth R; Carlson, Bryant; Simopoulos, Nicole; Jackson, Ann; Ganzini, Linda

    2006-01-01

    Although religiousness is a strong predictor of attitudes towards physician-assisted suicide (PAS), Oregon hospice chaplains express wide variation in their opposition to or support for legalized PAS. We explored factors associated with chaplains' views on PAS. A mailed survey to chaplains from 51 Oregon hospices. Fifty of 77 eligible hospice chaplains (65%) returned surveys. Views on PAS were associated with views on suicide in general. Moral and theological beliefs were the most important influences on views on PAS. Chaplains who were opposed to PAS believed that God alone may take life, that life is an absolute good, and that suffering has a divine purpose. Those who supported PAS placed emphasis on the importance of self-determination and sanctity of life as defined by quality of life. Oregon hospice chaplains' diverse views towards PAS are closely related to their views on suicide in general, and their personal and theological beliefs.

  8. 76 FR 52006 - Announcement of Funding Awards for the Assisted Living Conversion Program; Fiscal Year 2009

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... Awards for the Assisted Living Conversion Program; Fiscal Year 2009 AGENCY: Office of the Assistant... funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion Program (ALCP... for this program is 14.314. The Assisted Living Conversion Program is designed to provide funds to...

  9. 78 FR 28606 - Announcement of Funding Awards for the Assisted Living Conversion Program Fiscal Year 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Awards for the Assisted Living Conversion Program Fiscal Year 2012 AGENCY: Office of the Assistant... funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion Program (ALCP... for this program is 14.314. The Assisted Living Conversion Program is designed to provide funds to...

  10. 76 FR 59182 - Bureau of Educational and Cultural Affairs; Exchange Visitor Program; Summer Work Travel Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Visitor Program; Summer Work Travel Program Sponsor On-Site Reviews ACTION: Notice. SUMMARY: Pursuant to..., the Department announces its intent to conduct on- site reviews of sponsors in the Summer Work Travel... Work Travel Program provides foreign college and university students the opportunity to work and travel...

  11. 78 FR 60822 - Notice of Funding Availability for the Biorefinery Assistance Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Notice announces approximately $76 million in carry over budget authority that will support a program...(a). B. Statutory Authority. This Program is authorized under 7 U.S.C. 8103. Regulations are... provides approximately $76 million in available budget authority that will support a program level of...

  12. 75 FR 44055 - Promoting Postbaccalaureate Opportunities for Hispanic Americans (PPOHA) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... (PPOHA) Program; Notices #0;#0;Federal Register / Vol. 75 , No. 143 / Tuesday, July 27, 2010 / Notices#0... Americans (PPOHA) Program Catalog of Federal Domestic Assistance (CFDA) Number: 84.031M. AGENCY: Office of... Secretary for Postsecondary Education announces requirements under the PPOHA Program. The Assistant...

  13. 77 FR 63837 - Announcement of the Award of a Single-Source Program Expansion Supplement to One Grantee Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... incarcerated fathers designed to move individuals and families to self-sufficiency. SUMMARY: The Administration..., marriage and fatherhood programs, workforce development, and reentry programs designed to equip people to... will support the project's culinary arts training and employment, designed to prepare program...

  14. 77 FR 49782 - Extension of the Application Deadline for Humanitarian Awards Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ...] Extension of the Application Deadline for Humanitarian Awards Pilot Program AGENCY: United States Patent and... Trademark Office (USPTO) announced the Humanitarian Awards Pilot Program, which recognizes patent holders... extending the deadline for applications to the Humanitarian Awards Pilot Program by two months until October...

  15. 77 FR 57074 - Indirect Cost Rates for the Damage Assessment, Remediation, and Restoration Program for Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Damage Assessment, Remediation, and Restoration Program for Fiscal Year 2011 AGENCY: National Oceanic and..., Remediation, and Restoration Program for Fiscal Year 2011. SUMMARY: The National Oceanic and Atmospheric Administration's (NOAA's) Damage Assessment, Remediation, and Restoration Program (DARRP) is announcing new...

  16. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... program? Notice of opportunities for assistance to conduct an appraisal investigation or a feasibility study under § 404.11(a) or (b) will be posted as a program announcement on the required government-wide...

  17. 75 FR 73027 - Cooperative Conservation Partnership Initiative and Wetlands Reserve Enhancement Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... Corporation Cooperative Conservation Partnership Initiative and Wetlands Reserve Enhancement Program AGENCY... Initiative. SUMMARY: The Natural Resources Conservation Service (NRCS) announces the availability of... Partnership Initiative (CCPI) and up to $25 million in the Wetlands Reserve Enhancement Program (WREP) through...

  18. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Jeff Hanley, Constellation Program Manager, announces to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  19. 75 FR 10843 - Special Summer Postal Rate Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ..., Pricing Strategy, as the official available to provide prompt responses to requests for clarification from... special volume pricing incentive for certain Standard Mail this summer. This document announces... Standard Mail Volume Incentive Pricing Program (Standard Mail Incentive Program) similar to the one...

  20. 78 FR 79477 - Announcement of Funding Awards, Choice Neighborhoods Grant Program, Fiscal Year 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... to community development centered on housing transformation. The program aims to transform...-functioning services, effective schools and education programs, public assets, public transportation, and... comprehensive neighborhood revitalization strategy, or Transformation Plan. The Transformation Plan will become...

  1. [Psychoactive Drug Use by Youth in a Post Armed-Conflict Region].

    PubMed

    Díaz, Carlos Gantiva; Ramírez, Nohelia Hewitt; Maldonado, Anderssen Vera; Varela, Adriana Angarita; Baños, Arturo Parado; Puerto, Angélica Guillén

    2012-06-01

    There are no studies in Colombia on the use of psychoactive substances (PAS) by post armed-conflict population to serve as guide for prevention programs and to account for the potential impact armed conflict may have upon this area. To describe the use of PAS in young students in a post-conflict region. A quantitative-descriptive study involving the totality of students of the township of Viotá, Department of Cundinamarca, Colombia (1,304 participants). The World Health Survey for Schoolchildren was applied. Alcohol is the substance with the highest percentage of lifetime prevalence; during the last month, it was observed that the highest percentage of people start PAS use between the age of 8 and 13, while 42% of youngsters have experienced at least one drunkenness episode. It was found that 43.4% have been exposed to alcohol in their families while 35.1% were exposed to tobacco at school or in their neighborhoods. 84.5% stated their intention to continue consuming tobacco during the next year. Results show lower consumption percentages in comparison to school youngsters in Bogotá, Colombia, which may indicate that the armed conflict has not increased consumption levels in this population. Based on the results, certain elements to be taken into account are proposed for the implementation of prevention programs with this population. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  2. Anterior chamber angle imaging with swept-source optical coherence tomography: measuring peripheral anterior synechia in glaucoma.

    PubMed

    Lai, Isabel; Mak, Heather; Lai, Gilda; Yu, Marco; Lam, Dennis S C; Leung, Christopher K S

    2013-06-01

    To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. Cross-sectional study. Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and Axenfeld-Rieger syndrome [n = 1]). The anterior chamber angles were evaluated with indentation gonioscopy and imaged by swept-source OCT (Casia OCT, Tomey, Nagoya, Japan) in room light and in the dark using the "angle analysis" protocol, which was composed of 128 radial B-scans each with 512 A-scans (16-mm scan length). The area and degree of PAS involvement were measured in each eye after manual detection of the scleral spur and the anterior irido-angle adhesion by 2 masked observers. The interobserver variability of the PAS measurements was calculated. The agreement of PAS assessment by gonioscopy and OCT, the area and the degree of PAS involvement, and the intraclass correlation coefficient (ICC) of interobserver PAS measurements. The area of PAS (mean ± standard deviation) was 20.8 ± 16.9 mm(2) (range, 3.9-74.9 mm(2)), and the degree of PAS involvement was 186.5 ± 79.9 degrees (range, 42-314 degrees). There was no difference in the area of PAS (P = 0.90) and the degree of PAS involvement (P = 0.95) between images obtained in room light and in the dark. The interobserver ICCs were 0.99 (95% confidence interval [CI], 0.98-1.00) for the area of PAS and 0.99 (95% CI, 0.97-1.00) for the degree of PAS involvement. There was good agreement of PAS assessment between gonioscopy and OCT images (kappa = 0.79; 95% CI, 0.67-0.91). Swept-source OCT allows visualization and reproducible measurements of the area and degree of PAS involvement, providing a new paradigm for evaluation of PAS progression and risk assessment for development of angle-closure glaucoma. The author(s) have no proprietary or commercial interest in any materials discussed in this article. Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  3. 78 FR 9936 - Federal Housing Administration (FHA): PowerSaver Home Energy Retrofit Loan Pilot Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Administration (FHA): PowerSaver Home Energy Retrofit Loan Pilot Program: Extension of Pilot Program AGENCY...: On March 31, 2011, HUD published a notice that announced HUD's FHA Home Energy Retrofit Loan Pilot Program (Retrofit Pilot Program) known as FHA PowerSaver, which is a pilot program conducted for loans...

  4. Lotus tenuis x L. corniculatus interspecific hybridization as a means to breed bloat-safe pastures and gain insight into the genetic control of proanthocyanidin biosynthesis in legumes

    PubMed Central

    2014-01-01

    Background Proanthocyanidins (PAs) are secondary metabolites that strongly affect plant quality traits. The concentration and the structure of these metabolites influence the palatability and nutritional value of forage legumes. Hence, modulating PAs in the leaves of forage legumes is of paramount relevance for forage breeders worldwide. The lack of genetic variation in the leaf PA trait within the most important forage species and the difficulties in engineering this pathway via the ectopic expression of regulatory genes, prompted us to pursue alternative strategies to enhance this trait in forage legumes of agronomic interest. The Lotus genus includes forage species which accumulate PAs in edible organs and can thus be used as potential donor parents in breeding programs. Results We recovered a wild, diploid and PA-rich population of L. corniculatus and crossed with L. tenuis. The former grows in an alkaline-salty area in Spain while the latter is a diploid species, grown extensively in South American pastures, which does not accumulate PAs in the herbage. The resulting interspecific hybrids displayed several traits of outstanding agronomic relevance such as rhizome production, PA levels in edible tissues sufficient to prevent ruminal bloating (around 5 mg of PAs/g DW), biomass production similar to the cultivated parent and potential for adaptability to marginal lands. We show that PA levels correlate with expression levels of the R2R3MYB transcription factor TT2 and, in turn, with those of the key structural genes of the epicatechin and catechin biosynthetic pathways leading to PA biosynthesis. Conclusions The L. tenuis x L. corniculatus hybrids, reported herein, represent the first example of the introgression of the PA trait in forage legumes to levels known to provide nutritional and health benefits to ruminants. Apart from PAs, the hybrids have additional traits which may prove useful to breed forage legumes with increased persistence and adaptability to marginal conditions. Finally, our study suggests the hybrids and their progeny are an invaluable tool to gain a leap forward in our understanding of the genetic control of PA biosynthesis and tolerance to stresses in legumes. PMID:24490637

  5. Final priority; National Institute on Disability and Rehabilitation Research--Research Fellowships Program (also known as the Mary E. Switzer Research Fellowships). Final priority.

    PubMed

    2014-07-28

    The Assistant Secretary for Special Education and Rehabilitative Services announces a priority for the Research Fellowships Program administered by the National Institute on Disability and Rehabilitation Research (NIDRR). Specifically, this notice announces a priority for a Distinguished Residential Disability and Rehabilitation Policy Fellowship. We take this action to focus attention on an area of national need. We intend the priority to build research capacity by providing support to highly qualified, experienced researchers, including those who are individuals with disabilities, to conduct policy research in the areas of disability and rehabilitation.

  6. 48 CFR 15.602 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Small Business Innovation Research topics, Small Business Technology Transfer Research topics, Program Research and Development Announcements, or any other Government-initiated solicitation or program. When the....602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND...

  7. ECDA of Cased Pipeline Segments

    DOT National Transportation Integrated Search

    2010-06-01

    On June 28, 2007, PHMSA released a Broad Agency Announcement (BAA), DTPH56-07-BAA-000002, seeking white papers on individual projects and consolidated Research and Development (R&D) programs addressing topics on pipeline safety program. Although, not...

  8. FY 2017 Hazardous Waste Management Grant Program for Tribes

    EPA Pesticide Factsheets

    This notice announces the availability of funds and solicits proposals from federally-recognized tribes or intertribal consortia for the development and implementation of hazardous waste programs and for building capacity to address hazardous waste

  9. 76 FR 54773 - Notice of Intent To Award Affordable Care Act Funding, Funding Opportunity Announcement CDC-RFA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... activities including prevention research and health screenings, such as the Community Transformation Grant Program, the Education and Outreach Campaign for Preventative Benefits, and Immunization Programs. REACH...

  10. 76 FR 40734 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ...; Voluntary Cosmetic Registration Program AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... ``Voluntary Cosmetic Registration Program'' has been approved by the Office of Management and Budget [[Page...

  11. Enlisted Personnel Individualized Career System (EPICS) Test and Evaluation

    DTIC Science & Technology

    1984-01-01

    The EPICS program, which was developed using an integrated personnel systems approach ( IPSA ), delays formal school training until after personnel have...received shipboard on-job training complemented by job performance aids (3PAs). Early phases of the program, which involved developing the IPSA EPICS...detailed description of the conception and development of the EPICS IPSA model, the execution of the front-end job design analyses, 3PA and instructional

  12. Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro.

    PubMed

    Bazzocco, Sarah; Mattila, Ismo; Guyot, Sylvain; Renard, Catherine M G C; Aura, Anna-Marja

    2008-12-01

    Proanthocyanidins (PAs) in apples are condensed tannins comprised mostly of (-)-epicatechin units with some terminal (+)-catechins. PAs, especially those having a long chain-length, are absorbed in the upper intestine only to a small extent and are passed to the colon. In the colon they are subjected to microbial metabolism by colonic microbiota. In the present article, the ability of human microbiota to ferment apple PAs is studied. Freeze-dried fruit preparations (apple, enzymatically digested apple, isolated cell-walls, isolated PAs or ciders) from two varieties, Marie Ménard and Avrolles, containing PAs of different chain lengths, were compared. Fermentation studies were performed in an in vitro colon model using human faecal microbiota as an inoculum. The maximal extent of conversion to known microbial metabolites, was observed at late time point for Marie Ménard cider, having short PAs. In this case, the initial dose also contributed to the extent of conversion. Long-chain PAs were able to inhibit the in vitro microbial metabolism of PAs shown as low maxima at early time points. Presence of isolated PAs also suppressed SCFA formation from carbohydrates as compared with that from apple cell wall or faecal suspension without substrates. The low maximal extents at early time points suggest that there is a competition between the inhibitory effect of the PAs on microbial activity, and the ability to convert PAs by the microbiota.

  13. Measuring Individual Differences in the Perfect Automation Schema.

    PubMed

    Merritt, Stephanie M; Unnerstall, Jennifer L; Lee, Deborah; Huber, Kelli

    2015-08-01

    A self-report measure of the perfect automation schema (PAS) is developed and tested. Researchers have hypothesized that the extent to which users possess a PAS is associated with greater decreases in trust after users encounter automation errors. However, no measure of the PAS currently exists. We developed a self-report measure assessing two proposed PAS factors: high expectations and all-or-none thinking about automation performance. In two studies, participants responded to our PAS measure, interacted with imperfect automated aids, and reported trust. Each of the two PAS measure factors demonstrated fit to the hypothesized factor structure and convergent and discriminant validity when compared with propensity to trust machines and trust in a specific aid. However, the high expectations and all-or-none thinking scales showed low intercorrelations and differential relationships with outcomes, suggesting that they might best be considered two separate constructs rather than two subfactors of the PAS. All-or-none thinking had significant associations with decreases in trust following aid errors, whereas high expectations did not. Results therefore suggest that the all-or-none thinking scale may best represent the PAS construct. Our PAS measure (specifically, the all-or-none thinking scale) significantly predicted the severe trust decreases thought to be associated with high PAS. Further, it demonstrated acceptable psychometric properties across two samples. This measure may be used in future work to assess levels of PAS in users of automated systems in either research or applied settings. © 2015, Human Factors and Ergonomics Society.

  14. 75 FR 79087 - Fund Availability Under the Supportive Services for Veteran Families Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... DEPARTMENT OF VETERANS AFFAIRS Fund Availability Under the Supportive Services for Veteran... Veterans Affairs (VA) is announcing the availability of funds for supportive services grants under the Supportive Services for Veteran Families Program (SSVF Program). This Notice contains information concerning...

  15. 78 FR 21395 - Announcement of Funding Awards, Choice Neighborhoods Grant Program, Fiscal Year 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... Program employs a comprehensive approach to community development centered on housing transformation. The... leveraging investments in well-functioning services, effective schools and education programs, public assets... transformation of public and/or HUD-assisted housing developments through preservation, rehabilitation, and...

  16. Evaluating Motivational Interviewing in the Physician Assistant Curriculum.

    PubMed

    Halbach, Patrick; Keller, Abiola O

    2017-09-01

    Motivational interviewing (MI) is an evidence-based technique that enables clinicians to help patients modify health behaviors. Although MI is an essential tool for physician assistants (PAs), the extent to which it is addressed in PA curricula in the United States is unknown. This study is a comprehensive description of MI education in PA programs in the United States. Data are from the 2014 Physician Assistant Education Association Annual Program Survey. Descriptive statistics were conducted on de-identified data from all 186 PA programs in the United States. Of the 186 PA programs surveyed, 72.58% (n = 135) reported at least one course providing MI training. Availability of courses providing training in skills essential to the MI process varied. Having a course with verbal communication training was most frequently endorsed, and having a course with training in developing discrepancy was least frequently endorsed. The most popular teaching modality was lecture (84.95%, n = 158), whereas only 41.40% (n = 77) and 58.60% (n = 109) reported role play with evaluation and standardized patient exercises with evaluation, respectively. More than 70% of programs included at least one course in their curriculum that provided training in MI, suggesting that PA programs recognize the importance of MI. Instruction in change talk was not provided in nearly half of the programs. Role-play and standardized patient exercises with evaluation were underused methods despite their proven efficacy in MI education. As the first comprehensive benchmark of MI education for PAs, this study shows that although most programs address MI, opportunities exist to improve MI training in PA programs in the United States.

  17. Examination of the association between announced inspections and inspection scores.

    PubMed

    Waters, A Blake; VanDerslice, James; Porucznik, Christina A; Kim, Jaewhan; DeLegge, Royal; Durrant, Lynne

    2013-09-01

    In 2010 the Salt Lake Valley Health Department conducted a pilot of an announced inspection program utilizing a randomized assignment of restaurants to an intervention group with announced inspections and a control group that remained on the usual schedule of unannounced inspections. After adjusting for food type, visible kitchen, outside quality assurance, season, and standardized inspector, significant reductions were found in the odds ratios of personal hygiene (adjusted odds ratios [aOR] = 0.11, p = .00) and equipment cleanliness (aOR = 0.19, p = .00) violations. In the models for the control group, none of the odds ratios were statistically different from one, indicating no change in the postintervention time period as compared to the preintervention period.

  18. Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

    DOE PAGES

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun; ...

    2016-04-06

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly builtmore » computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms.Moreover, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.« less

  19. Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly builtmore » computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms.Moreover, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.« less

  20. A history of US Army PAs.

    PubMed

    Chalupa, Robyn L; Marble, W Sanders

    2017-11-01

    The US military has a long tradition of using physician assistants (PAs). The Army began using PAs in 1971 in an effort to supplement the physicians and surgeons in the medical corps. As their numbers grew, PAs gradually replaced general medical officers assigned to battalions. Later, specialty positions developed in aviation medicine, orthopedics, and emergency medicine. The need for a PA serving as an adviser in the major commands slowly developed at all levels of leadership. In 2015, the Army removed limitations on female PAs assigned to combat units. PAs lead in tactical and clinical settings, filling command roles, senior clinical positions, and administrative leadership roles.

  1. Panic attacks and hoarding disorder: an initial investigation.

    PubMed

    Raines, Amanda M; Oglesby, Mary E; Short, Nicole A; Albanese, Brian J; Schmidt, Norman B

    2014-08-01

    Panic attacks (PAs) defined as a discrete period of intense fear or discomfort, occur in the context of numerous anxiety and mood related disorders. Research has suggested that PAs serve as a significant indicator and prognostic factor for overall symptom severity, course, and comorbidity within various conditions. Consequently, a PA specifier is now applicable to all DSM-5 disorders. Despite these clinical and nosological implications, no research to date has examined associations between PAs and hoarding disorder. The current investigation evaluated relationships between PA endorsement and hoarding severity within a sample of 32 patients with hoarding disorder. Findings suggested a high rate of panic history among those with hoarding disorder (56%). Hoarders with co-occurring PAs, compared to those without PAs, evidenced significantly higher symptom severity. Moreover, PAs continued to significantly predict hoarding severity even after controlling for relevant covariates. When examining the specific relationships among PAs and hoarding symptoms (i.e., acquiring, difficulty discarding, and clutter), the endorsement of PAs was associated with increased acquiring and difficulty discarding symptoms. These findings add considerably to a growing body of literature on hoarding disorder. Implications for the assessment and treatment of PAs that co-occur with hoarding disorder are discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards.

    PubMed

    Zhu, Lin; Ruan, Jian-Qing; Li, Na; Fu, Peter P; Ye, Yang; Lin, Ge

    2016-03-01

    Nearly 50% of naturally-occurring pyrrolizidine alkaloids (PAs) are hepatotoxic, and the majority of hepatotoxic PAs are retronecine-type PAs (RET-PAs). However, quantitative measurement of PAs in herbs/foodstuffs is often difficult because most of reference PAs are unavailable. In this study, a rapid, selective, and sensitive UHPLC-QTOF-MS method was developed for the estimation of RET-PAs in herbs without requiring corresponding standards. This method is based on our previously established characteristic and diagnostic mass fragmentation patterns and the use of retrorsine for calibration. The use of a single RET-PA (i.e. retrorsine) for construction of calibration was based on high similarities with no significant differences demonstrated by the calibration curves constructed by peak areas of extract ion chromatograms of fragment ion at m/z 120.0813 or 138.0919 versus concentrations of five representative RET-PAs. The developed method was successfully applied to measure a total content of toxic RET-PAs of diversified structures in fifteen potential PA-containing herbs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus

    PubMed Central

    2013-01-01

    Background The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). Results A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6–9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. Conclusions This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a tremendous amount of variation in the number of PDC/PAS-containing proteins within genera. This variation extended to the Staphylococcus genus, which had between 6 and 9 PDC/PAS proteins and some of these appear to be previously undescribed signaling proteins. This latter point is important because most staphylococcal proteins that contain PDC/PAS domains regulate virulence factor synthesis or antibiotic resistance. PMID:23902280

  4. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.

    PubMed

    Shah, Neethu; Gaupp, Rosmarie; Moriyama, Hideaki; Eskridge, Kent M; Moriyama, Etsuko N; Somerville, Greg A

    2013-07-31

    The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6-9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a tremendous amount of variation in the number of PDC/PAS-containing proteins within genera. This variation extended to the Staphylococcus genus, which had between 6 and 9 PDC/PAS proteins and some of these appear to be previously undescribed signaling proteins. This latter point is important because most staphylococcal proteins that contain PDC/PAS domains regulate virulence factor synthesis or antibiotic resistance.

  5. The practice of euthanasia and physician-assisted suicide in the United States: adherence to proposed safeguards and effects on physicians.

    PubMed

    Emanuel, E J; Daniels, E R; Fairclough, D L; Clarridge, B R

    1998-08-12

    Despite intense debates about legalization, there are few data examining the details of actual euthanasia and physician-assisted suicide (PAS) cases in the United States. To determine whether the practices of euthanasia and PAS are consistent with proposed safeguards and the effect on physicians of having performed euthanasia or PAS. Structured in-depth telephone interviews. Randomly selected oncologists in the United States. Adherence to primary and secondary safeguards for the practice of euthanasia and PAS; regret, comfort, and fear of prosecution from performing euthanasia or PAS. A total of 355 oncologists (72.6% response rate) were interviewed on euthanasia and PAS. On 2 screening questions, 56 oncologists (15.8%) reported participating in euthanasia or PAS; 53 oncologists (94.6% response rate) participated in in-depth interviews. Thirty-eight of 53 oncologists described clearly defined cases of euthanasia or PAS. Twenty-three patients (60.5%) both initiated and repeated their request for euthanasia or PAS, but 6 patients (15.8%) did not participate in the decision for euthanasia or PAS. Thirty-seven patients (97.4%) were experiencing unremitting pain or such poor physical functioning they could not perform self-care. Physicians sought consultation in 15 cases (39.5%). Overall, oncologists adhered to all 3 main safeguards in 13 cases (34.2%): (1) having the patient initiate and repeat the request for euthanasia or PAS, (2) ensuring the patient was experiencing extreme physical pain or suffering, and (3) consulting with a colleague. Those who adhered to the safeguards had known their patients longer and tended to be more religious. In 28 cases (73.7%), the family supported the decision. In all cases of pain, patients were receiving narcotic analgesia. Fifteen patients (39.5%) were enrolled in a hospice. While 19 oncologists (52.6%) received comfort from having helped a patient with euthanasia or PAS, 9 (23.7%) regretted having performed euthanasia or PAS, and 15 (39.5%) feared prosecution. Intractable pain or poor physical functioning seem to be nearly absolute requirements for physicians to perform euthanasia or PAS. Only one third of cases are performed consistently with proposed safeguards. For some patients, end-of-life care that includes opioid analgesia and hospice care does not obviate their desire for euthanasia or PAS. While the majority of physicians seem comforted by their actions, some experience adverse consequences from having performed euthanasia or PAS.

  6. 78 FR 60285 - Final Notice To Announce the Implementation of Required Electronic Submission of State or Tribal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... Financial Reporting Forms for Mandatory Grant Programs AGENCY: Office of Administration (OA), ACF, HHS... Tribal plans, and program and financial reporting forms for mandatory grant programs to ACF's Online Data... mandatory grant programs will be required to submit State plans, and programmatic and financial reporting...

  7. 77 FR 3788 - Announcement of Funding Awards for the Assisted Living Conversion Program; Fiscal Year 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Awards for the Assisted Living Conversion Program; Fiscal Year 2010 AGENCY: Office of the Assistant... competition for funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion... Assistance number for this program is 14.314. The Assisted Living Conversion Program is designed to provide...

  8. 75 FR 16493 - Announcement of Funding Awards for the Public and Indian Housing Family Self-Sufficiency Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Awards for the Public and Indian Housing Family Self-Sufficiency Program Under the Resident Opportunity... (NOFA) for the Public and Indian Housing Family Self-Sufficiency Program under the Resident Opportunity... Public and Indian Housing Family Self-Sufficiency Program under the Resident Opportunity and Self...

  9. 76 FR 55407 - Announcement of Funding Awards; Public and Indian Housing Family Self-Sufficiency Program Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ...; Public and Indian Housing Family Self-Sufficiency Program Under the Resident Opportunity and Self... (NOFA) for the Public and Indian Housing Family Self-Sufficiency Program Under the Resident Opportunity.... Appendix A--List of Public and Indian Housing Family Self-Sufficiency Program Under the Resident...

  10. 77 FR 23461 - Notice of Request for Applications for the Veterinary Medicine Loan Repayment Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... Applications for the Veterinary Medicine Loan Repayment Program AGENCY: National Institute of Food and... announcing the release of the Veterinary Medicine Loan Repayment Program (VMLRP) Request for Applications (RFA) at www.nifa.usda.gov/vmlrp . DATES: The FY 2012 Veterinary Medicine Loan Repayment Program (VMLRP...

  11. FNLM 2013 Events & Programs Announced | NIH MedlinePlus the Magazine

    MedlinePlus

    ... expand programs that promote medical education and health literacy in several related areas. Professional Education In Spring ... site: www.fnlm.org Mobile MedlinePlus! Trusted medical information on your mobile phone. http://m.medlineplus.gov ...

  12. 76 FR 18555 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... announced below concerns Economic Studies of Vaccines and Immunization Policies, Programs, and Practices... to ``Economic Studies of Vaccines and Immunization Policies, Programs, and Practices, FOA IP11-007...

  13. FY 2018 Hazardous Waste Management Grant Program For Tribes

    EPA Pesticide Factsheets

    This notice announces the availability of funds and solicits proposals from federally-recognized tribes or intertribal consortia for the development and implementation of hazardous waste programs and for building capacity to address hazardous waste managem

  14. A Guide to Organizing Short-term Study Abroad Programs. Series on Languages and Linguistics No. 4.

    ERIC Educational Resources Information Center

    Griffith, Paul T.

    This guide is designed for those interested in organizing and/or participating in short-term study abroad programs. The following main topics are treated in detail: (1) the nature of the program, (2) the budget, (3) winning administrative approval for the program, (4) announcing the program, (5) orientation, (6) the program director, (7) the…

  15. 76 FR 25748 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals; International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... for Grant Proposals; International Visitor Leadership Program Assistance Award Announcement Type: New... awards to administer the International Visitor Leadership Program (IVLP). The IVLP is the U.S. Department... legislation. Purpose: The International Visitor Leadership Program seeks to increase mutual understanding...

  16. 75 FR 34994 - Office of Postsecondary Education; Overview Information; Predominantly Black Institutions Formula...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... enrollment. (f) Efficiency Measure: Cost per successful program outcome: Federal cost per undergraduate... Black Institutions Formula Grant Program; Notice Inviting Applications for New Awards for Fiscal Year..., 2010. Full Text of Announcement I. Funding Opportunity Description Purpose of Program: Through the...

  17. 76 FR 27648 - World Trade Center (WTC) Health Program Scientific/Technical Advisory Committee; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade... Prevention (CDC), announces the establishment of the World Trade Center (WTC) Health Program Scientific..., Designated Federal Officer, World Trade Center Health Program Scientific/Technical Advisory Committee...

  18. 78 FR 54255 - HRSA's Bureau of Health Professions Advanced Education Nursing Traineeship Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... of Health Professions Advanced Education Nursing Traineeship Program AGENCY: Health Resources and... announcing a change to its Advanced Education Nursing Traineeship (AENT) program. Effective fiscal year (FY... Wasserman, DrPH, RN, Advanced Nursing Education Branch Chief, Division of Nursing, Bureau of Health...

  19. Navy Aegis Ballistic Missile Defense (BMD) Program: Background and Issues for Congress

    DTIC Science & Technology

    2016-10-25

    for European BMD On September 17, 2009, the Obama Administration announced a new approach for regional BMD operations called the Phased Adaptive...December 2010, the U.S. missile defense approach in Europe commits MDA to delivering systems and associated capabilities on a schedule that requires...announcement of the European Phased Adaptive Approach on September 17, 2009, stated, “This approach is based on an assessment of the Iranian missile

  20. Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae.

    PubMed Central

    Erdmann, R; Veenhuis, M; Mertens, D; Kunau, W H

    1989-01-01

    Two mutants of Saccharomyces cerevisiae affected in peroxisomal assembly (pas mutants) have been isolated and characterized. Each strain contains a single mutation that results in (i) the inability to grow on oleic acid, (ii) accumulation of peroxisomal matrix enzymes in the cytosol, and (iii) absence of detectable peroxisomes at the ultrastructural level. These lesions (pas1-1 and pas2) are shown to be nonallelic and recessive. Crossing of pas1-1 and pas2 strains resulted in diploid cells that had regained the ability to grow on oleic acid as sole carbon source and to form peroxisomes. These pas mutants may provide useful tools for future studies on the molecular mechanisms involved in peroxisomal assembly. Images PMID:2568633

  1. The Interservice Physician Assistant Program: Education quantity and quality.

    PubMed

    Harrison, Randolph Scott; Adamson, Katherine Justen; Kroger, Shan Michael

    2015-12-01

    The Interservice Physician Assistant Program (IPAP) was formed in 1996 by the assimilation of three service programs (Army, Air Force, and Navy). Applicants are selected from each service and upon successful completion of the program become commissioned officers within their respective medical corps. Clinical training takes place within military treatment facilities across the United States. Located in San Antonio, Texas, the program graduates about 169 PAs a year. Graduates are deployed to attend to service personnel, refugees, civilians, and victims of epidemics. The IPAP is unique in that it is the largest PA program in the world and its applicant pool is restricted to military personnel.

  2. 77 FR 61002 - Announcement of the Award of Single-Source Program Expansion Supplement Grants to Seven Assets...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    .... Grantees also ensure that participants have access to financial literacy education and coaching such as.../ 2017. FOR FURTHER INFORMATION CONTACT: Al Fleming, Program Manager, Assets for Independence, 370 L... . SUPPLEMENTARY INFORMATION: The following AFI grantees will receive single-source program expansion supplement...

  3. 77 FR 1743 - U.S. Antarctic Program Blue Ribbon Panel; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... NATIONAL SCIENCE FOUNDATION U.S. Antarctic Program Blue Ribbon Panel; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation announces the following meeting: Name: U.S. Antarctic Program Blue Ribbon Panel Review, 76826. Date/Time...

  4. 75 FR 27000 - Hearings of the Review Panel on Prison Rape

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OJP) Docket No. 1519] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

  5. 76 FR 20711 - Hearings of the Review Panel on Prison Rape

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OCR) Docket No. 1548] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

  6. 78 FR 77495 - Hearings of the Review Panel on Prison Rape

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OCR) Docket No. 1642] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of Hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

  7. 78 FR 66670 - Housing Counseling Program: New Certification Requirements; Extension of Public Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Counseling Program: New Certification Requirements; Extension of Public Comment Period AGENCY: Office of the... inviting public comment on proposed changes to the Housing Counseling Program regulations for the purpose... housing counseling statute. This document announces that HUD is extending the public comment period, for...

  8. The Real World Spanish Cassette Program. Script Book.

    ERIC Educational Resources Information Center

    Sternburg, Sheldon G.

    This dual cassette program, accompanied by a script book, is designed to give students listening practice in Spanish, particularly for regional differences of pronunciation and for variety in idiomatic construction. The program may be integrated with texts used in intermediate and advanced levels of instruction. The announcements, jingles, and…

  9. 77 FR 34411 - National Industrial Security Program Policy Advisory Committee (NISPPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION National Industrial Security Program Policy Advisory... CFR 101-6, announcement is made for the following committee meeting. To discuss National Industrial Security Program policy matters. DATES: This meeting will be held on Wednesday, July 11, 2012 from 10:00 a...

  10. 76 FR 19174 - State Trade and Export Promotion (STEP) Pilot Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... SMALL BUSINESS ADMINISTRATION State Trade and Export Promotion (STEP) Pilot Grant Program AGENCY... No. OIT-STEP-2011-01, Modification 1. SUMMARY: Program announcement No. OIT-STEP-2011-01 has been... to the date of application submission for a STEP grant.] Section IV A. 1, Governor's Letter of...

  11. 77 FR 70783 - Medicare and Medicaid Programs; Approval of the Accreditation Association for Ambulatory Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ...] Medicare and Medicaid Programs; Approval of the Accreditation Association for Ambulatory Health Care (AAAHC... announces our decision to approve the Accreditation Association for Ambulatory Health Care (AAAHC) for... Ambulatory Health Care's (AAAHC) current term of approval for their ASC accreditation program expires on...

  12. 77 FR 27475 - Announcement of Funding Awards; Choice Neighborhoods Grant Program for Fiscal Years (FY) 2010 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... community development centered on housing transformation. The program aims to transform neighborhoods of...-functioning services, effective schools and education programs, public assets, public transportation, and improved access to jobs. Choice Neighborhoods grants primarily funds the transformation of public and/or...

  13. 76 FR 21741 - Twenty-First Century Communications and Video Programming Accessibility Act; Announcement of Town...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 11-428] Twenty-First Century Communications and Video... The Twenty-First Century Communications and Video Programming Accessibility Act (the Act or CVAA... orientation to the Act, and discussed the advanced communications and video programming changes required by...

  14. 78 FR 42788 - American Indians Into Nursing; Notice of Competitive Grant Applications for American Indians Into...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Indian Health Service American Indians Into Nursing; Notice of Competitive Grant Applications for American Indians Into Nursing Program Announcement Type... the American Indians into Nursing Program (Section 112). This program is authorized under Section 112...

  15. 78 FR 53425 - Indirect Cost Rates for the Damage Assessment, Remediation, and Restoration Program for Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... DEPARTMENT OF COMMERCE Indirect Cost Rates for the Damage Assessment, Remediation, and Restoration.... ACTION: Notice of Indirect Cost Rates for the Damage Assessment, Remediation, and Restoration Program for... Assessment, Remediation, and Restoration Program (DARRP) is announcing new indirect cost rates on the...

  16. 75 FR 26283 - Proposed Collection, Submission for OMB Review, Museums for America Grant Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Review, Museums for America Grant Program Evaluation AGENCY: Institute of Museum and Library Services..., Submission for OMB Review. SUMMARY: The Institute of Museum and Library Services announces the following... responses. ADDRESSES: Erica Pastore, Program Analyst, Institute of Museum and Library Services, 1800 M St...

  17. 76 FR 34953 - Funding Opportunity Title: Risk Management Education in Targeted States (Targeted States Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Corporation Funding Opportunity Title: Risk Management Education in Targeted States (Targeted States Program... Corporation (FCIC), operating through the Risk Management Agency (RMA), announces its intent to award... same time as funding availability for similar but separate program, the Risk Management Education and...

  18. EPA Releases Guidance on a Voluntary Pilot Program to Reduce Animal Testing

    EPA Pesticide Factsheets

    EPA is announcing the start of a voluntary pilot program to evaluate the usefulness and acceptability of a mathematical tool that estimates the toxicological classification of a chemical, which is used in the GHS.

  19. 78 FR 14315 - Notice of Chargeable Rates Under the National Flood Insurance Program for Non-Primary Residences

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ...] Notice of Chargeable Rates Under the National Flood Insurance Program for Non-Primary Residences AGENCY... residences. DATES: The rates announced in this notice are effective January 1, 2013. [[Page 14316

  20. Mixtures Equation Pilot Program to Reduce Animal Testing

    EPA Pesticide Factsheets

    EPA is announcing the start of a pilot program to evaluate the usefulness and acceptability of a mathematical tool (the GHS Mixtures Equation), which is used in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

  1. 76 FR 80342 - Coastal Zone Management Program: Illinois

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Coastal Zone Management Program: Illinois AGENCY: Office of Ocean and Coastal Resource Management (OCRM), National Oceanic and... Environmental Impact Statement. SUMMARY: NOAA's Office of Ocean and Coastal Resource Management (OCRM) announces...

  2. 7 CFR 3406.5 - Matching support.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Program Description... contributions in support of capacity building projects. CSREES may also announce any required fixed dollar...

  3. Efficiency of protected areas in Amazon and Atlantic Forest conservation: A spatio-temporal view

    NASA Astrophysics Data System (ADS)

    Sobral-Souza, Thadeu; Vancine, Maurício Humberto; Ribeiro, Milton Cezar; Lima-Ribeiro, Matheus S.

    2018-02-01

    The Amazon and Atlantic Forest are considered the world's most biodiverse biomes. Human and climate change impacts are the principal drivers of species loss in both biomes, more severely in the Atlantic Forest. In response to species loss, the main conservation action is the creation of protected areas (PAs). Current knowledge and research on the PA network's conservation efficiency is scarce, and existing studies have mainly considered a past temporal view. In this study, we tested the efficiency of the current PA network to maintain climatically stable areas (CSAs) across the Amazon and Atlantic Forest. To this, we used an ecological niche modeling approach to biome and paleoclimatic simulations. We propose three categories of conservation priority areas for both biomes, considering CSAs, PAs and intact forest remnants. The biomes vary in their respective PA networks' protection efficiency. Regarding protect CSAs, the Amazon PA network is four times more efficient than the Atlantic Forest PA network. New conservation efforts in these two forest biomes require different approaches. We discussed the conservation actions that should be taken in each biome to increase the efficiency of the PA network, considering both the creation and expansion of PAs as well as restoration programs.

  4. Ethical Issues in the Social Worker's Role in Physician-Assisted Suicide.

    ERIC Educational Resources Information Center

    Manetta, Ameda A.; Wells, Janice G.

    2001-01-01

    Presents results of an exploratory study of social workers' views on physician-assisted suicide (PAS), situations in which PAS would be favored, and whether there is a difference in education or training on mental health issues, ethics, or suicide between social workers who favor PAS and those who oppose PAS. (BF)

  5. Proanthocyanidins of mountain birch leaves: quantification and properties.

    PubMed

    Ossipova, S; Ossipov, V; Haukioja, E; Loponen, J; Pihlaja, K

    2001-01-01

    Proanthocyanidins (PAs; condensed tannins) are present in mountain birch leaves in soluble and cell wall-bound forms. Crude preparations of soluble PAs were isolated from birch leaves and purified by chromatography on a Sephadex LH-20 column with a yield of about 7% of leaf dry mass. Some chemical characteristics were elucidated with 13C-NMR and HPLC-ECI-MS. Birch leaf PAs were mainly delphinidin type oligo- and polymers with average molecular mass of about 3000. In order to quantify PAs, the method involving heating PA-containing materials in 1-butanol:hydrochloric acid (95:5, v/v), and spectrophotometric determination of the anthocyanidin monomers so formed was modified and optimised. Mature leaves were characterised by a relatively high content of PAs: mean values for soluble and bound PAs were 103 and 40 mg/g dry mass, respectively. In mature leaves the soluble PAs determined the total protein precipitation capacity (PPC) of extracts. In young leaves, the contribution of PAs to the total content of phenolics and the total PPC of tannins was about 20-25% only.

  6. PAS positivity of erythroid precursor cells is associated with a poor prognosis in newly diagnosed myelodysplastic syndrome patients.

    PubMed

    Masuda, Kenta; Shiga, Shuichi; Kawabata, Hiroshi; Takaori-Kondo, Akifumi; Ichiyama, Satoshi; Kamikubo, Yasuhiko

    2018-07-01

    Myelodysplastic syndrome (MDS) is a group of clonal stem cell disorders characterized by hematopoietic insufficiency. The accurate risk stratification of patients with MDS is essential for selection of appropriate therapies. We herein conducted a retrospective cohort study to examine the prognostic value of periodic acid-Schiff (PAS) reaction-positive erythroblasts in MDS patients. We examined the PAS positivity of the bone marrow erythroblasts of 144 patients newly diagnosed with MDS; 26 (18.1%) of them had PAS-positive erythroblasts, whereas 118 (81.9%) did not. The PAS-positive group showed significantly poorer karyotypes as defined in the revised International Prognostic Scoring System (IPSS-R) and higher scores in age-adjusted IPSS-R (IPSS-RA) than the PAS-negative group. Overall survival (OS) and leukemia-free survival (LFS) were also significantly shorter in the PAS-positive group than in the PAS-negative group. Similar results were obtained when only high- and very high risk groups were analyzed using IPSS-RA. This retrospective study suggested that the PAS positivity of erythroblasts is an additional prognostic factor combined with other risk scores for OS and LFS in MDS, and our results may contribute to improved clinical decision-making and rapid risk stratification.

  7. Understanding protected area resilience: a multi-scale, social-ecological approach.

    PubMed

    Cumming, Graeme S; Allen, Craig R; Ban, Natalie C; Biggs, Duan; Biggs, Harry C; Cumming, David H M; De Vos, Alta; Epstein, Graham; Etienne, Michel; Maciejewski, Kristine; Mathevet, Raphaël; Moore, Christine; Nenadovic, Mateja; Schoon, Michael

    2015-03-01

    Protected areas (PAs) remain central to the conservation of biodiversity. Classical PAs were conceived as areas that would be set aside to maintain a natural state with minimal human influence. However, global environmental change and growing cross-scale anthropogenic influences mean that PAs can no longer be thought of as ecological islands that function independently of the broader social-ecological system in which they are located. For PAs to be resilient (and to contribute to broader social-ecological resilience), they must be able to adapt to changing social and ecological conditions over time in a way that supports the long-term persistence of populations, communities, and ecosystems of conservation concern. We extend Ostrom's social-ecological systems framework to consider the long-term persistence of PAs, as a form of land use embedded in social-ecological systems, with important cross-scale feedbacks. Most notably, we highlight the cross-scale influences and feedbacks on PAs that exist from the local to the global scale, contextualizing PAs within multi-scale social-ecological functional landscapes. Such functional landscapes are integral to understand and manage individual PAs for long-term sustainability. We illustrate our conceptual contribution with three case studies that highlight cross-scale feedbacks and social-ecological interactions in the functioning of PAs and in relation to regional resilience. Our analysis suggests that while ecological, economic, and social processes are often directly relevant to PAs at finer scales, at broader scales, the dominant processes that shape and alter PA resilience are primarily social and economic.

  8. Understanding protected area resilience: a multi-scale, social-ecological approach

    USGS Publications Warehouse

    Cumming, Graeme S.; Allen, Craig R.; Ban, Natalie C.; Biggs, Duan; Biggs, Harry C.; Cumming, David H.M; De Vos, Alta; Epstein, Graham; Etienne, Michel; Maciejewski, Kristine; Mathevet, Raphael; Moore, Christine; Nenadovic, Mateja; Schoon, Michael

    2015-01-01

    Protected areas (PAs) remain central to the conservation of biodiversity. Classical PAs were conceived as areas that would be set aside to maintain a natural state with minimal human influence. However, global environmental change and growing cross-scale anthropogenic influences mean that PAs can no longer be thought of as ecological islands that function independently of the broader social-ecological system in which they are located. For PAs to be resilient (and to contribute to broader social-ecological resilience), they must be able to adapt to changing social and ecological conditions over time in a way that supports the long-term persistence of populations, communities, and ecosystems of conservation concern. We extend Ostrom's social-ecological systems framework to consider the long-term persistence of PAs, as a form of land use embedded in social-ecological systems, with important cross-scale feedbacks. Most notably, we highlight the cross-scale influences and feedbacks on PAs that exist from the local to the global scale, contextualizing PAs within multi-scale social-ecological functional landscapes. Such functional landscapes are integral to understand and manage individual PAs for long-term sustainability. We illustrate our conceptual contribution with three case studies that highlight cross-scale feedbacks and social-ecological interactions in the functioning of PAs and in relation to regional resilience. Our analysis suggests that while ecological, economic, and social processes are often directly relevant to PAs at finer scales, at broader scales, the dominant processes that shape and alter PA resilience are primarily social and economic.

  9. Advanced practice registered nurses and physician assistants in sleep centers and clinics: a survey of current roles and educational background.

    PubMed

    Colvin, Loretta; Cartwright, Ann; Collop, Nancy; Freedman, Neil; McLeod, Don; Weaver, Terri E; Rogers, Ann E

    2014-05-15

    To survey Advanced Practice Registered Nurse (APRN) and Physician Assistant (PA) utilization, roles and educational background within the field of sleep medicine. Electronic surveys distributed to American Academy of Sleep Medicine (AASM) member centers and APRNs and PAs working within sleep centers and clinics. Approximately 40% of responding AASM sleep centers reported utilizing APRNs or PAs in predominantly clinical roles. Of the APRNs and PAs surveyed, 95% reported responsibilities in sleep disordered breathing and more than 50% in insomnia and movement disorders. Most APRNs and PAs were prepared at the graduate level (89%), with sleep-specific education primarily through "on the job" training (86%). All APRNs surveyed were Nurse Practitioners (NPs), with approximately double the number of NPs compared to PAs. APRNs and PAs were reported in sleep centers at proportions similar to national estimates of NPs and PAs in physicians' offices. They report predominantly clinical roles, involving common sleep disorders. Given current predictions that the outpatient healthcare structure will change and the number of APRNs and PAs will increase, understanding the role and utilization of these professionals is necessary to plan for the future care of patients with sleep disorders. Surveyed APRNs and PAs reported a significant deficiency in formal and standardized sleep-specific education. Efforts to provide formal and standardized educational opportunities for APRNs and PAs that focus on their clinical roles within sleep centers could help fill a current educational gap.

  10. Evaluation and application of a passive air sampler for polycylic aromatic hydrocarbons (PAHs).

    PubMed

    Esen, Fatma; Evci, Yildiz M; Tasdemir, Yucel

    2017-08-24

    Sampling of 15 PAHs by the use of both passive air sampler developed (D-PAS) in our research group and PAS (C-PAS) having widespread use in the literature was conducted to compare the performances of the samplers. Sampling was carried out for 1-year period (February 2013-February 2014), in different sampling periods by employing D-PAS and C-PAS. D-PAS and C-PAS were run in parallel for 10, 20, 30, 40 and 60 days. Sampling rates were calculated for both PASs by the use of concentration values obtained from a high-volume air sampler (HVAS). It was determined that calculated sampling values are different from each other by definition of design of C-PAS and D-PAS and difference in environment as velocity of wind and temperature are having different effects upon sampling rates. Collected σ 15 PAHs amounts of 10-day periods in spring, summer, autumn and winter were obtained as 576 ± 333, 209 ± 29, 2402 ± 910 and 664 ± 246 ng for D-PAS and 1070 ± 522, 318 ± 292, 6062 ± 1501 and 6089 ± 4018 ng for C-PAS, respectively. In addition, according to seasons, when collected PAHs in two different samplers were considered, similar results were obtained for the summer time in which no combustion takes place with the aim of domestic heating, while there were differences determined for the seasons with combustion in need of domestic heating. Gas-phase σ 15 PAHs' concentrations were reported depending on seasons in the spring, summer, autumn and winter sequences as 46 ± 32, 9 ± 3, 367 ± 207 and 127 ± 93 ng m -3 for HVAS, respectively.

  11. Medicare, Medicaid, and Children's Health Insurance Programs: Announcement of the Extension of Temporary Moratoria on Enrollment of Part B Non-Emergency Ground Ambulance Suppliers and Home Health Agencies in Designated Geographic Locations. Extension of temporary moratoria.

    PubMed

    2017-07-28

    This document announces the extension of statewide temporary moratoria on the enrollment of new Medicare Part B non-emergency ground ambulance providers and suppliers and Medicare home health agencies, subunits, and branch locations in Florida, Illinois, Michigan, Texas, Pennsylvania, and New Jersey, as applicable, to prevent and combat fraud, waste, and abuse. This extension also applies to the enrollment of new non-emergency ground ambulance suppliers and home health agencies, subunits, and branch locations in Medicaid and the Children's Health Insurance Program in those states.

  12. 77 FR 14540 - Announcement of Funding Awards for the Public and Indian Housing Family Self-Sufficiency Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... Awards for the Public and Indian Housing Family Self-Sufficiency Program Under the Resident Opportunity... Funding Availability (NOFA) for the Public and Indian Housing Family Self-Sufficiency Program under the... amounts of the 238 awards made under the Public and Indian Housing Family Self-Sufficiency Program under...

  13. 76 FR 10082 - Office of International Trade; State Trade and Export Promotion (STEP) Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... (STEP) Grant Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of grant... Program Announcement No. OIT-STEP-2011- 01 to invite the States, the District of Columbia and the U.S. Territories to apply for a STEP grant to carry out export promotion programs that assist eligible small...

  14. The many worlds of Ida.

    PubMed

    Fleagle, John G

    2010-01-01

    The early primate fossil that forms the type specimen of Darwinius masillae, known informally as Ida, was first announced in a spectacular media blitz in May 2009, including a publication in the journal PLoS ONE, a public unveiling at the American Museum of Natural History, massive coverage by television and newspapers, a documentary program on the History Channel, and a book. However, reaction to the fossil by other scientists was largely critical of its purported significance, and later publications have reached very different conclusions than those promoted in the original announcements. Moreover, there are inconsistencies in the information provided by the scientific paper, the book, and the public announcements. What is the source of these discrepancies, and what is the relationship between scientific progress and media coverage?

  15. FY2019 Pacific Southwest (Region 9) Tribal Clean Air Act Funding Announcement and Guidance

    EPA Pesticide Factsheets

    Information about grants to federally-recognized tribes in EPA's Pacific Southwest (Region 9) geographic area for funding tribal air pollution control programs, air quality education and assessment projects, and development of tribal air program capacity.

  16. 75 FR 52054 - Bus and Bus Facilities Discretionary Program Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... engaged in public transportation, or private non-profit organizations. FOR FURTHER INFORMATION CONTACT... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Bus and Bus Facilities Discretionary... program announcement of project selections. SUMMARY: The U.S. Department of Transportation's (DOT) Federal...

  17. 77 FR 43229 - Food and Nutrition Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... DEPARTMENT OF AGRICULTURE Food and Nutrition Service Child and Adult Care Food Program: National... AGENCY: Food and Nutrition Service, USDA. ACTION: Notice. SUMMARY: This notice announces the annual... Namian, Section Head, Policy and Program Development Branch, Child Nutrition Division, Food and Nutrition...

  18. 48 CFR 15.604 - Agency points of contact.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... preparing a detailed unsolicited proposal or submitting proprietary information to the Government may save... of unsolicited proposals at least the following information: (1) Definition (see 2.101) and content...

  19. 48 CFR 15.604 - Agency points of contact.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... preparing a detailed unsolicited proposal or submitting proprietary information to the Government may save... of unsolicited proposals at least the following information: (1) Definition (see 2.101) and content...

  20. 76 FR 314 - Sorghum Promotion, Research, and Information Program: Referendum

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-10-0103] Sorghum Promotion, Research, and Information Program: Referendum AGENCY: Agricultural Marketing Service, USDA... Referendum. SUMMARY: The Agricultural Marketing Service (AMS) is announcing that a referendum will be...

  1. 75 FR 34148 - Voluntary Private Sector Accreditation and Certification Preparedness Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ...] Voluntary Private Sector Accreditation and Certification Preparedness Program AGENCY: Federal Emergency...) announces its adoption of three standards for the Voluntary Private Sector Accreditation and Certification... DHS to develop and implement a Voluntary Private Sector Preparedness Accreditation and Certification...

  2. Space agency notes 20th anniversary

    NASA Technical Reports Server (NTRS)

    Frosch, R. A.

    1978-01-01

    The twentieth anniversary of NASA is announced. A chronology of major milestones of the NASA program is given along with a brief outline of the programs and responsibilities of NASA Headquarters and the NASA centers and facilities. The NASA launch record is included.

  3. 76 FR 22673 - Technology Innovation Program Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce... Standards and Technology (NIST) published a notice in the Federal Register announcing an open meeting for...

  4. Management of land use land cover through the application of remote sensing, geographic information systems and simulation

    NASA Astrophysics Data System (ADS)

    Jha, Praveen

    Deforestation and degradation of forest areas, including those in the Protected Areas (PAs), are major concerns in India. There were 2 broad objectives of the study: the technological objective pertained to the development of state-of-art programs that could serve as Decision Support Systems while finalizing plans and policy interventions, while the other objective aimed at generating geo-spatial data in 2 PAs. A part of the Eastern Himalaya biodiversity hotspot, Manas Tiger Reserve (MTR), Assam, India having an area of 2837.12 sq km and an important part of Rajaji-Corbett Tiger Conservation Unit, Rajaji National Park (RNP), Uttarakhand, India, having an area of 820.42 sq km, were taken for the assessment of land use and land cover (LULC) change during 1990--2004. Simulation was undertaken in a smaller area of 1.2 km * 1.2 km right on the fringe of RNP. Three advanced geo-spatial programs---Multi-Algorithm Automation Program (MAAP), Data Automatic Modification Program (DAMP) and Multi-Stage Simulation Program (MUSSIP)---developed by the author were used extensively. Based on the satellite data, MAAP was used for the rapid assessments of LULC of 2004 and 1990; DAMP was used for the spectral modification of the satellite data of the adjacent scenes of 2004 and of 1990; and MUSSIP was used to simulate LULC maps for the future periods (till 2018). These programs produced very high accuracy levels: 91.12% in 2004 and 89.67% in 1990 were obtained for MTR; and 94.87% in 2004 and 94.10% in 1990 were obtained for RNP; 93.40% pixel-to-pixel accuracy and 0.7904 for kappa were achieved for simulation. The annual rate of loss of forests (0.41% in MTR and 1.20% in RNP) and loss of water (1.79% in MTR and 1.69% in RNP) during 1990-2004 is a matter of serious concern. The scenario analysis in the study area for simulation revealed that the deforestation rate of 1.27% per year during 2004--2018 would increase to 2.04% if the human population growth rate is enhanced by 10%. Hence these PAs need urgent restoration measures and effective conservation planning to address the problems of deforestation, severe degradation and immense loss of water.

  5. Introducing the Lifetime Exercise and Physical Activity Service-Learning (LE PAS) Program

    ERIC Educational Resources Information Center

    Carson, Russell L.

    2008-01-01

    In August and September 2005, two violent hurricanes--Katrina and Rita--hit Louisiana. Hundreds of thousands of residents were relocated to temporary living communities, where most of the economically poor remain today. This state's largest trailer community, "Renaissance Village," was erected almost overnight in a cow pasture in Baker,…

  6. Identifying Preservation and Restoration Priority Areas for Desert Fishes in an Increasingly Invaded World

    NASA Astrophysics Data System (ADS)

    Pool, Thomas K.; Strecker, Angela L.; Olden, Julian D.

    2013-03-01

    A commonly overlooked aspect of conservation planning assessments is that wildlife managers are increasingly focused on habitats that contain non-native species. We examine this management challenge in the Gila River basin (150,730 km2), and present a new planning strategy for fish conservation. By applying a hierarchical prioritization algorithm to >850,000 fish records in 27,181 sub-watersheds we first identified high priority areas (PAs) termed "preservation PAs" with high native fish richness and low non-native richness; these represent traditional conservation targets. Second, we identified "restoration PAs" with high native fish richness that also contained high numbers of non-native species; these represent less traditional conservation targets. The top 10 % of preservation and restoration PAs contained common native species (e.g., Catostomus clarkii, desert sucker; Catostomus insignis, Sonora sucker) in addition to native species with limited distributions (i.e., Xyrauchen texanus, razorback sucker; Oncorhynchus gilae apache, Apache trout). The top preservation and restoration PAs overlapped by 42 %, indicating areas with high native fish richness range from minimally to highly invaded. Areas exclusively identified as restoration PAs also encompassed a greater percentage of native species ranges than would be expected by the random addition of an equivalent basin area. Restoration PAs identified an additional 19.0 and 26.6 % of the total ranges of two federally endangered species— Meda fulgida (spikedace) and Gila intermedia (Gila chub), respectively, compared to top preservation PAs alone—despite adding only 5.8 % of basin area. We contend that in addition to preservation PAs, restoration PAs are well suited for complementary management activities benefiting native fishes.

  7. Legal physician-assisted suicide in Oregon and The Netherlands: evidence concerning the impact on patients in vulnerable groups--another perspective on Oregon's data.

    PubMed

    Finlay, I G; George, R

    2011-03-01

    Battin et al examined data on deaths from physician-assisted suicide (PAS) in Oregon and on PAS and voluntary euthanasia (VE) in The Netherlands. This paper reviews the methodology used in their examination and questions the conclusions drawn from it-namely, that there is for the most part 'no evidence of heightened risk' to vulnerable people from the legalisation of PAS or VE. This critique focuses on the evidence about PAS in Oregon. It suggests that vulnerability to PAS cannot be categorised simply by reference to race, gender or other socioeconomic status and that the impetus to seek PAS derives from factors, including emotional state, reactions to loss, personality type and situation and possibly to PAS contagion, all factors that apply across the social spectrum. It also argues, on the basis of official reports from the Oregon Health Department on the working of the Oregon Death with Dignity Act since 2008, that, contrary to the conclusions drawn by Battin et al, the highest resort to PAS in Oregon is among the elderly and, on the basis of research published since Battin et al reported, that there is reason to believe that some terminally ill patients in Oregon are taking their own lives with lethal drugs supplied by doctors despite having had depression at the time when they were assessed and cleared for PAS.

  8. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of Onychomycosis.

    PubMed

    Jeelani, Shazia; Ahmed, Qazi Masood; Lanker, Audil Mohmad; Hassan, Iffat; Jeelani, Nasir; Fazili, Tawheeda

    2015-01-01

    Onychomycosis is fungal infection of one or more of the nail units. However, because fungi cause only about half of all nail dystrophies, the use of appropriate diagnostic techniques is important to ensure correct diagnosis and treatment. Aim of the present study was to compare direct microscopy, culture and HPE-PAS for diagnosis of onychomycosis by evaluating their sensitivity and various other relevant statistical parameters. A prospective, hospital-based, cross-sectional study was conducted on 216 patients with a high degree of clinical suspicion of onychomycosis. Nail specimens were evaluated using three diagnostic methods, i.e. direct microscopy using 20% Potassium hydroxide (KOH) & 40% Di-methyl-suphoxide (DMSO), culture and histopathological examination using PAS stain (HPE-PAS). Of 216 patients direct microscopy was positive in 138 (63.9%), culture in 147 (68%) and HPE-PAS in 164 patients (76%). One hundred and seventy-nine patients fitted into the criteria set for confirmed diagnosis of onychomycosis. Using this as a denominator; direct microscopy, culture and HPE-PAS had sensitivities of 77.1%, 70% and 91.6% respectively. Also, HPE-PAS showed the highest sensitivity of 94.7% in 19 cases with prediagnostic antimycotic treatment compared to direct microscopy (42.1%) or culture (57.9%). HPE-PAS shows high sensitivity for diagnosis of onychomycosis and can be considered as a gold standard in the diagnosis of onychomycosis. © 2014 Blackwell Verlag GmbH.

  9. Associative plasticity in intracortical inhibitory circuits in human motor cortex.

    PubMed

    Russmann, Heike; Lamy, Jean-Charles; Shamim, Ejaz A; Meunier, Sabine; Hallett, Mark

    2009-06-01

    Paired associative stimulation (PAS) is a transcranial magnetic stimulation technique inducing Hebbian-like synaptic plasticity in the human motor cortex (M1). PAS is produced by repetitive pairing of a peripheral nerve shock and a transcranial magnetic stimulus (TMS). Its effect is assessed by a change in size of a motor evoked response (MEP). MEP size results from excitatory and inhibitory influences exerted on cortical pyramidal cells, but no robust effects on inhibitory networks have been demonstrated so far. In 38 healthy volunteers, we assessed whether a PAS intervention influences three intracortical inhibitory circuits: short (SICI) and long (LICI) intracortical inhibitions reflecting activity of GABA(A) and GABA(B) interneurons, respectively, and long afferent inhibition (LAI) reflecting activity of somatosensory inputs. After PAS, MEP sizes, LICI and LAI levels were significantly changed while changes of SICI were inconsistent. The changes in LICI and LAI lasted 45 min after PAS. Their direction depended on the delay between the arrival time of the afferent volley at the cortex and the TMS-induced cortical activation during the PAS. PAS influences inhibitory circuits in M1. PAS paradigms can demonstrate Hebbian-like plasticity at selected inhibitory networks as well as excitatory networks.

  10. Physician-assisted suicide-a clean bill of health?

    PubMed

    Preston, Robert

    2017-09-01

    Physician-assisted suicide (PAS) laws have been enacted in five US States and, along with physician-administered euthanasia, in Canada and the Netherlands. Annual reports of the Oregon Health Authority and published research papers. Not all recipients of lethal drugs use them to end their lives. Improvements in palliative care provision. Rising numbers of deaths from PAS. Emergence of 'doctor shopping' and multiple-prescribing. Absence of qualitative scrutiny of assessment process. No re-assessment or oversight when prescribed drugs are ingested. Recent pressures to extend Oregon's PAS law. Reasons given for seeking PAS indicate this is a societal rather than a clinical issue and raise the question whether adjudicating on requests for legalized PAS is an appropriate role for doctors. Research into quality of decision-making in requests for PAS and into potential role of doctors as expert witnesses rather than judges in requests for PAS. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  11. 700 Honor ARC Pioneers and Founders at Gathering in Washington.

    ERIC Educational Resources Information Center

    Appalachia, 1985

    1985-01-01

    The Appalachian Regional Commission celebrated its 20th anniversary by honoring commission pioneers and founders at a Washington, DC, gathering. A new program aimed at lowering the region's school dropout rate was announced at the banquet. State plans and investment programs and a finish-up program accomplishments were approved at a business…

  12. 75 FR 75532 - Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ...] Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report AGENCY: Federal Highway... participating in the Pilot Program, 23 U.S.C. 327(g) mandates semiannual audits during each of the first 2 years of State participation. This notice announces and solicits comments on the fifth audit report for the...

  13. 77 FR 9707 - U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... NATIONAL SCIENCE FOUNDATION U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation announces the following meeting: Name: U.S. Antarctic Program Blue Ribbon Panel Review, 76826. Date/Time...

  14. 76 FR 63329 - U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... NATIONAL SCIENCE FOUNDATION U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation announces the following meeting: Name: U.S. Antarctic Program Blue Ribbon Panel Review (76826). Date/Time...

  15. 77 FR 20852 - U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-06

    ... NATIONAL SCIENCE FOUNDATION U.S. Antarctic Program Blue Ribbon Panel Review; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation announces the following meeting: Name: U.S. Antarctic Program Blue Ribbon Panel Review, 76826. Date/Time...

  16. 76 FR 17936 - Federal Housing Administration (FHA): Notice of FHA PowerSaver Home Energy Retrofit Loan Pilot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... Housing Administration (FHA): Notice of FHA PowerSaver Home Energy Retrofit Loan Pilot Program AGENCY...: Notice. SUMMARY: This notice announces HUD's FHA Home Energy Retrofit Loan Pilot Program (Retrofit Pilot... to conduct an Energy Efficient Mortgage Innovation pilot program targeted to the single family...

  17. 78 FR 25292 - Announcement of Funding Awards; Office of Native American Programs Training and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... Awards; Office of Native American Programs Training and Technical Assistance; Fiscal Year 2012 AGENCY... (NOFA) for the Office of Native American Programs Training and Technical Assistance (ONAP T&TA). This... nonprofit organizations, as well as for-profit entities to provide Training & Technical Assistance to the...

  18. 78 FR 19799 - National Baseball Hall of Fame Commemorative Coin Program Design Competition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... competition, which Challenge.gov is hosting, to select a common obverse design emblematic of the game of... Program Design Competition ACTION: Notification of the Opening of the National Baseball Hall of Fame Commemorative Coin Program Design Competition on April 11, 2013. SUMMARY: The United States Mint announces the...

  19. 77 FR 16796 - Lead Requirements for Lead-Based Paint Activities in Target Housing and Child-Occupied Facilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... document announces the receipt of Arkansas's rules established pursuant to its new 2011 statutory authority... program accreditation requirements, and work practice standards for lead-based paint activities in target...-based paint program and passed a new statute establishing a State lead-based paint program and changing...

  20. 77 FR 51021 - Ultra-Deepwater and Unconventional Natural Gas and Other Petroleum Resources, Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ..., Research and Development Program 2012 Annual Plan AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of report availability. SUMMARY: The Office of Fossil Energy announces the availability of... Resources Research and Development Program on the DOE Web site at www.fossil.energy.gov/programs/oilgas...

  1. 76 FR 56412 - Ultra-Deepwater and Unconventional Natural Gas and Other Petroleum Resources Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Research and Development Program 2011 Annual Plan AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of report availability. SUMMARY: The Office of Fossil Energy announces the availability of... Resources Research and Development Program on the DOE Web site at http://www.fossil.energy.gov/programs...

  2. 78 FR 54510 - New Entrant Safety Assurance Program Operational Test

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ...-0298] New Entrant Safety Assurance Program Operational Test AGENCY: Federal Motor Carrier Safety...) announces an operational test of procedural changes to the New Entrant Safety Assurance Program. The operational test began in July 2013 and will be in effect for up to 12 months. It is applicable to new entrant...

  3. Constellation Program Update

    NASA Image and Video Library

    2006-06-05

    Jeff Hanley, Constellation Program Manager, right, and Scott J. Horowitz, NASA Associate Administrator for Exploration Systems announce to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  4. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Scott J. Horowitz, NASA Associate Administrator for Exploration Systems, left, and Jeff Hanley, Constellation Program Manager, announce to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  5. 78 FR 25417 - Notice of Request for Applications for the Veterinary Medicine Loan Repayment Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Applications for the Veterinary Medicine Loan Repayment Program AGENCY: National Institute of Food and... announcing the release of the Veterinary Medicine Loan Repayment Program (VMLRP) Request for Applications (RFA) at www.nifa.usda.gov/vmlrp . DATES: The fiscal year (FY) 2013 Veterinary Medicine Loan Repayment...

  6. 77 FR 61012 - Expansion of Importer Self-Assessment Program To Include Qualified Importers of Focused...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ...-Assessment Program To Include Qualified Importers of Focused Assessment Audits AGENCY: U.S. Customs and... undergoing comprehensive CBP audits. This document announces that a company that has successfully undergone a CBP Focused Assessment (FA) audit may be eligible to transition into the ISA program without further...

  7. 76 FR 1641 - Meeting of the Office of Justice Programs' Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... of Justice Programs' Science Advisory Board AGENCY: Office of Justice Programs (OJP), Justice. ACTION: Notice of meeting. SUMMARY: This is an announcement of the first meeting of OJP's Science Advisory Board... advice in the areas of social science and statistics for the purpose of enhancing the overall impact and...

  8. 76 FR 12127 - Emergency Homeowners' Loan Program: Announcement of Activation of Program and Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... are not limited to: Developing and disseminating program marketing materials; Providing an overview of... sale, deed-in-lieu of foreclosure, or traditional sale of home. B. Intermediary to Perform Funds... modification, short sale, deed-in-lieu of foreclosure, or traditional sale of home. 2. Repayment of Emergency...

  9. 76 FR 66318 - Announcement of Funding Awards; Limited English Proficiency Initiative Program (LEPI), Fiscal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... Awards; Limited English Proficiency Initiative Program (LEPI), Fiscal Year 2010/2011 AGENCY: Office of... (NOFA) for the Limited English Proficiency Initiative (LEPI) Program for Fiscal Year (FY) 2010/2011... activities for persons who, as a result of national origin, are limited in the English proficiency (LEP...

  10. 76 FR 68116 - Structure and Practices of the Video Relay Service Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... Practices of the Video Relay Service Program AGENCY: Federal Communications Commission. ACTION: Interim rule... with the Commission's Structure and Practices of the Video Relay Service Program, Second Report and... announcement of the effective date of the rules. See, In the Matter of Structure and Practices of the Video...

  11. Clinical Investigator Development Program | Center for Cancer Research

    Cancer.gov

    Clinical Investigator Development Program Application Deadline:  September 30, 2018 Program Starts: July 1, 2019 The NCI Center for Cancer Research (CCR) is pleased to announce our annual call for applications for an exciting training opportunity intended for physicians interested in dedicating their careers to clinical research. Come join a vibrant, multidisciplinary research

  12. 75 FR 68790 - Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual Deductible...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... 0938-AP81 Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual... (SMI) program beginning January 1, 2011. In addition, this notice announces the monthly premium for... beneficiaries with modified adjusted gross income above certain threshold amounts. The monthly actuarial rates...

  13. 76 FR 67572 - Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual Deductible...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... 0938-AQ16 Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual... (SMI) program beginning January 1, 2012. In addition, this notice announces the monthly premium for... beneficiaries with modified adjusted gross income above certain threshold amounts. The monthly actuarial rates...

  14. 78 FR 64943 - Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual Deductible...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... 0938-AR58 Medicare Program; Medicare Part B Monthly Actuarial Rates, Premium Rate, and Annual... (SMI) program beginning January 1, 2014. In addition, this notice announces the monthly premium for... beneficiaries with modified adjusted gross income above certain threshold amounts. The monthly actuarial rates...

  15. The Role of Glia in Stress: Polyamines and Brain Disorders

    PubMed Central

    Skatchkov, Serguei; Woodbury, Michel; Eaton, Misty

    2014-01-01

    Synopsis This review focuses on the roles of glia and polyamines (PAs) in brain function and dysfunction, highlighting how PAs are one of the principal differences between glia and neurons as they are surprisingly stored, but not synthesized, almost exclusively in glial cells from which they can be released to regulate neuronal synaptic activity. The review includes the novel role of PAs, such as putrescine (PUT), spermidine (SPD) and spermine (SPM) and their precursors and derivatives. However: (i) PAs have not yet been a focus of much glial research; (ii) PAs affect many neuronal and glial receptors, channels and transporters; (iii) PAs are therefore key elements in the development of many diseases and syndromes (iv) thus forming the rationale for PA and glia focused therapy for these conditions. PMID:25455070

  16. 77 FR 52614 - Pre-Existing Condition Insurance Plan Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ...This document contains an amendment regarding program eligibility to the interim final regulation implementing the Pre- Existing Condition Plan program under provisions of the Patient Protection and Affordable Care Act. In light of a new process recently announced by the Department of Homeland Security, eligibility for the program is being amended so that the program does not inadvertently expand the scope of that process.

  17. 76 FR 5427 - TIGGER and Clean Fuels Grant Program Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... will reduce the energy consumption or greenhouse gas emissions of public transportation systems. The... DEPARTMENT OF TRANSPORTATION Federal Transit Administration TIGGER and Clean Fuels Grant Program... Announcement of Project Selections. SUMMARY: The U.S. Department of Transportation's (DOT) Federal Transit...

  18. 48 CFR 917.7300 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 917.7300 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7300 Scope of subpart. (a) This subpart discusses the policy for the use of a program research and development...

  19. 76 FR 18766 - Early Retiree Reinsurance Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services [CMS-9996-N] Early Retiree Reinsurance Program AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS. ACTION: Notice. SUMMARY: This notice announces that CMS is exercising its authority under section 1102(f) of the...

  20. 75 FR 81315 - Earth Sciences Proposal Review Panel; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... NATIONAL SCIENCE FOUNDATION Earth Sciences Proposal Review Panel; Notice of Meeting In accordance... announces the following meeting. Name: Proposal Review Panel in Earth Sciences (1569). Date and Time... Kelz, Program Director, Instrumentation & Facilities Program, Division of Earth Sciences, Room 785...

  1. 78 FR 53423 - Notice of Funds Availability Under the Intermediary Relending Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... DEPARTMENT OF AGRICULTURE Rural Business-Cooperative Service Notice of Funds Availability Under the Intermediary Relending Program AGENCIES: Rural Business-Cooperative Service, USDA. ACTION: Notice. SUMMARY: The Rural Business-Cooperative Service announces that the funds available under the Intermediary...

  2. 76 FR 17738 - Over-the-Road Bus Accessibility Program Announcement of Project Selections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... Transportation Equity Act for the 21st Century (TEA-21). The OTRB Accessibility Program makes funds available to... to any new vehicles delivered on or after June 9, 1998, the effective date of TEA-21, is eligible for...

  3. 77 FR 45650 - Interior Fire Program Assessment 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Interior Fire Program Assessment 2012 AGENCY: Office of Wildland Fire, Interior. ACTION: Notice of Tribal consultations and informational meetings. SUMMARY: The Office of Wildland Fire is announcing tribal consultations to discuss the following topics...

  4. 75 FR 27741 - National Institute on Disability and Rehabilitation Research (NIDRR); Disability and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... DEPARTMENT OF EDUCATION National Institute on Disability and Rehabilitation Research (NIDRR); Disability and Rehabilitation Research Projects and Centers Program; Rehabilitation Research and Training... Rehabilitation Research Projects and Centers Program administered by NIDRR. Specifically, this notice announces a...

  5. 7 CFR 3415.14 - Proposal review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications...., relationship of application to announced program area). Proposals that do not fall within the guidelines as... officers or employees of the Department, the respective peer review group, and ad hoc reviewers, as...

  6. 7 CFR 3415.14 - Proposal review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications...., relationship of application to announced program area). Proposals that do not fall within the guidelines as... officers or employees of the Department, the respective peer review group, and ad hoc reviewers, as...

  7. 7 CFR 3415.14 - Proposal review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications...., relationship of application to announced program area). Proposals that do not fall within the guidelines as... officers or employees of the Department, the respective peer review group, and ad hoc reviewers, as...

  8. 76 FR 4350 - Health Information Technology Extension Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Information Technology Extension Program ACTION: Public Notice. SUMMARY: This notice announces changes to the Health Information Technology Extension... technology, as authorized under section 3012(c) of the Public Health Service Act, as added by the American...

  9. 7 CFR 1493.230 - Eligible transactions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC.... From time to time CCC will issue program announcements indicating the availability of facility payment... the emerging markets, the maximum amount, in U.S. dollars, of guarantee exposure that CCC will...

  10. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... providers as necessary to maintain the viability of the PAS system. 5. Maintain a database for PAS related... NSEP PAS database only to those having a need-to-know or who will not use the information for economic... selected for this priority should be responsible for ensuring the viability or reconstruction of the basic...

  11. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... providers as necessary to maintain the viability of the PAS system. 5. Maintain a database for PAS related... NSEP PAS database only to those having a need-to-know or who will not use the information for economic... selected for this priority should be responsible for ensuring the viability or reconstruction of the basic...

  12. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... providers as necessary to maintain the viability of the PAS system. 5. Maintain a database for PAS related... NSEP PAS database only to those having a need-to-know or who will not use the information for economic... selected for this priority should be responsible for ensuring the viability or reconstruction of the basic...

  13. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... providers as necessary to maintain the viability of the PAS system. 5. Maintain a database for PAS related... NSEP PAS database only to those having a need-to-know or who will not use the information for economic... selected for this priority should be responsible for ensuring the viability or reconstruction of the basic...

  14. Changes in Quaternary Structure in the Signaling Mechanisms of PAS Domains

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ayers, Rebecca A.; Moffat, Keith

    2008-12-15

    FixL from Bradyrhizobium japonicum is a PAS sensor protein in which two PAS domains covalently linked to a histidine kinase domain are responsible for regulating nitrogen fixation in an oxygen-dependent manner. The more C-terminal PAS domain, denoted bjFixLH, contains a heme cofactor that binds diatomic molecules such as carbon monoxide and oxygen and regulates the activity of the FixL histidine kinase as part of a two-component signaling system. We present the structures of ferric, deoxy, and carbon monoxide-bound bjFixLH in a new space group (P1) and at resolutions (1.5--1.8 {angstrom}) higher than the resolutions of those previously obtained. Interestingly, bjFixLHmore » can form two different dimers (in P1 and R32 crystal forms) in the same crystallization solution, where the monomers in one dimer are rotated {approx}175 deg. relative to the second. This suggests that PAS monomers are plastic and that two quite distinct quaternary structures are closely similar in free energy. We use screw rotation analysis to carry out a quantitative pairwise comparison of PAS quaternary structures, which identifies five different relative orientations adopted by isolated PAS monomers. We conclude that PAS monomer arrangement is context-dependent and could differ depending on whether the PAS domains are isolated or are part of a full-length protein. Structurally homologous residues comprise a conserved dimer interface. Using network analysis, we find that the architecture of the PAS dimer interface is continuous rather than modular; the network of residues comprising the interface is strongly connected. A continuous dimer interface is consistent with the low dimer-monomer dissociation equilibrium constant. Finally, we quantitate quaternary structural changes induced by carbon monoxide binding to a bjFixLH dimer, in which monomers rotate by up to 2 deg. relative to each other. We relate these changes to those in other dimeric PAS domains and discuss the role of quaternary structural changes in the signaling mechanisms of PAS sensor proteins.« less

  15. fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex

    PubMed Central

    Michou, Emilia; Williams, Steve; Vidyasagar, Rishma; Downey, Darragh; Mistry, Satish; Edden, Richard A.E.; Hamdy, Shaheen

    2016-01-01

    Introduction Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). Methods Healthy adults (n = 11, 38 ± 9 years old) were randomised to receive real and sham PAS to the ‘stronger’ motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P < .001. MRS data were acquired using MEGA-PRESS before and after the fMRI acquisitions on both visits and GABA concentrations were measured (AMARES, jMRUI). Results Following real PAS, BOLD signal changes (group analyses) increased at the site of stimulation during water and saliva swallowing, compared to sham PAS. It is also evident that PAS induced significant increases in BOLD signal to contralateral (to stimulation) hemispheric areas that are of importance to the swallowing neural network. Following real PAS, GABA: creatine ratio showed a trend to increase contralateral to PAS. Conclusion Targeted PAS applied to the human pharyngeal motor cortex induces local and remote changes in both primary and non-primary areas for water and saliva tasks. There is a possibility that changes of the inhibitory neurotransmitter, GABA, may play a role in the changes in BOLD signal. These findings provide evidence for the mechanisms underlying the beneficial effects of PAS on the brain swallowing network. PMID:25976926

  16. Pyrrolizidine and tropane alkaloids in teas and the herbal teas peppermint, rooibos and chamomile in the Israeli market.

    PubMed

    Shimshoni, Jakob Avi; Duebecke, Arne; Mulder, Patrick P J; Cuneah, Olga; Barel, Shimon

    2015-01-01

    Dehydro pyrrolizidine alkaloids (dehydro PAs) are carcinogenic phytotoxins prevalent in the Boraginaceae, Asteraceae and Fabaceae families. Dehydro PAs enter the food and feed chain by co-harvesting of crops intended for human and animal consumption as well as by carry-over into animal-based products such as milk, eggs and honey. Recently the occurrence of dehydro PAs in teas and herbal teas has gained increasing attention from the EU, due to the high levels of dehydro PAs found in commercially available teas and herbal teas in Germany and Switzerland. Furthermore, several tropane alkaloids (TAs, e.g. scopolamine and hyoscyamine) intoxications due to the consumption of contaminated herbal teas were reported in the literature. The aim of the present study was to determine the dehydro PAs and TAs levels in 70 pre-packed teabags of herbal and non-herbal tea types sold in supermarkets in Israel. Chamomile, peppermint and rooibos teas contained high dehydro PAs levels in almost all samples analysed. Lower amounts were detected in black and green teas, while no dehydro PAs were found in fennel and melissa herbal teas. Total dehydro PAs concentrations in chamomile, peppermint and rooibos teas ranged from 20 to 1729 μg/kg. Except for black tea containing only mono-ester retrorsine-type dehydro PAs, all other teas and herbal teas showed mixed patterns of dehydro PA ester types, indicating a contamination by various weed species during harvesting and/or production. The TA levels per teabag were below the recommended acute reference dose; however, the positive findings of TAs in all peppermint tea samples warrant a more extensive survey. The partially high levels of dehydro PAs found in teas and herbal teas present an urgent warning letter to the regulatory authorities to perform routine quality control analysis and implement maximum residual levels for dehydro PAs.

  17. Identifying preservation and restoration priority areas for desert fishes in an increasingly invaded world.

    PubMed

    Pool, Thomas K; Strecker, Angela L; Olden, Julian D

    2013-03-01

    A commonly overlooked aspect of conservation planning assessments is that wildlife managers are increasingly focused on habitats that contain non-native species. We examine this management challenge in the Gila River basin (150,730 km(2)), and present a new planning strategy for fish conservation. By applying a hierarchical prioritization algorithm to >850,000 fish records in 27,181 sub-watersheds we first identified high priority areas (PAs) termed "preservation PAs" with high native fish richness and low non-native richness; these represent traditional conservation targets. Second, we identified "restoration PAs" with high native fish richness that also contained high numbers of non-native species; these represent less traditional conservation targets. The top 10 % of preservation and restoration PAs contained common native species (e.g., Catostomus clarkii, desert sucker; Catostomus insignis, Sonora sucker) in addition to native species with limited distributions (i.e., Xyrauchen texanus, razorback sucker; Oncorhynchus gilae apache, Apache trout). The top preservation and restoration PAs overlapped by 42 %, indicating areas with high native fish richness range from minimally to highly invaded. Areas exclusively identified as restoration PAs also encompassed a greater percentage of native species ranges than would be expected by the random addition of an equivalent basin area. Restoration PAs identified an additional 19.0 and 26.6 % of the total ranges of two federally endangered species-Meda fulgida (spikedace) and Gila intermedia (Gila chub), respectively, compared to top preservation PAs alone-despite adding only 5.8 % of basin area. We contend that in addition to preservation PAs, restoration PAs are well suited for complementary management activities benefiting native fishes.

  18. Arranging for personal assistance services and assistive technology at work. A report of the rehabilitation research and training center on personal assistance services.

    PubMed

    Stoddard, Susan; Kraus, Lewis

    2006-01-01

    For an employee with a disability, reasonable accommodation can make the difference in finding work, maintaining employment, and succeeding on the job. Today, employers and employees alike are more aware that appropriate accommodation, including workplace personal assistance services (PAS) as well as assistive technology, improves an employee's ability to succeed. While assistive technology is in widespread use as an accommodation, workplace personal assistance is less understood. The goal of the study was to learn more about how workplace PAS and AT are arranged for in the workplace, and the issues that arise. Structured phone interviews were conducted with 20 workplace PAS users, 21 employers familiar with workplace PAS, and 19 employment organizations. Interview transcripts are the basis for the qualitative analysis of findings. Requirements for personal assistance accommodations focus on task-related needs. Personal care needs at work are not included in the Americans with Disabilities act but may be needed by the employee. Employers and PAS users have developed many creative ways to address PAS need. Organizations can construct an approach that fits the needs, abilities, and constraints of each organization. The interview respondents have identified a number of practices that are succeeding, including establishment of policies for arranging for PAS; centralization of accommodation budgets to remove work unit disincentives; and providing a shared personal assistant for interpreting or for task-related and personal care tasks. A number of important research questions remain. What is the extent of the need for PAS in the workplace? Will an expanded PAS supply increase the employment opportunities for people with disabilities? Will better models of workplace PAS be adopted by employers?

  19. Advanced Practice Registered Nurses and Physician Assistants in Sleep Centers and Clinics: A Survey of Current Roles and Educational Background

    PubMed Central

    Colvin, Loretta; Cartwright, Ann; Collop, Nancy; Freedman, Neil; McLeod, Don; Weaver, Terri E.; Rogers, Ann E.

    2014-01-01

    Study Objectives: To survey Advanced Practice Registered Nurse (APRN) and Physician Assistant (PA) utilization, roles and educational background within the field of sleep medicine. Methods: Electronic surveys distributed to American Academy of Sleep Medicine (AASM) member centers and APRNs and PAs working within sleep centers and clinics. Results: Approximately 40% of responding AASM sleep centers reported utilizing APRNs or PAs in predominantly clinical roles. Of the APRNs and PAs surveyed, 95% reported responsibilities in sleep disordered breathing and more than 50% in insomnia and movement disorders. Most APRNs and PAs were prepared at the graduate level (89%), with sleep-specific education primarily through “on the job” training (86%). All APRNs surveyed were Nurse Practitioners (NPs), with approximately double the number of NPs compared to PAs. Conclusions: APRNs and PAs were reported in sleep centers at proportions similar to national estimates of NPs and PAs in physicians' offices. They report predominantly clinical roles, involving common sleep disorders. Given current predictions that the outpatient healthcare structure will change and the number of APRNs and PAs will increase, understanding the role and utilization of these professionals is necessary to plan for the future care of patients with sleep disorders. Surveyed APRNs and PAs reported a significant deficiency in formal and standardized sleep-specific education. Efforts to provide formal and standardized educational opportunities for APRNs and PAs that focus on their clinical roles within sleep centers could help fill a current educational gap. Citation: Colvin L, Cartwright Ann, Collop N, Freedman N, McLeod D, Weaver TE, Rogers AE. Advanced practice registered nurses and physician assistants in sleep centers and clinics: a survey of current roles and educational background. J Clin Sleep Med 2014;10(5):581-587. PMID:24812545

  20. KSC-2012-4601

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  1. KSC-2012-4606

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  2. KSC-2012-4600

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – NASA Administrator Charlie Bolden, right, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  3. KSC-2012-4607

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  4. KSC-2012-4602

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  5. KSC-2012-4605

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  6. KSC-2012-4604

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  7. KSC-2012-4603

    NASA Image and Video Library

    2012-08-23

    CAPE CANAVERAL, Fla. – Space Florida President Frank DiBello, NASA Administrator Charlie Bolden, and Boeing's Vice President and General Manager of Space Exploration John Elbon address the media inside Orbiter Processing Facility-3, or OPF-3, at NASA's Kennedy Space Center in Florida. Bolden took a few dozen media on a road show tour of the center and adjacent Cape Canaveral Air Force Station to show the progress being made for future government and commercial space endeavors that will begin from Florida's Space Coast. Boeing is leasing OPF-3 through an agreement with Space Florida for the manufacturing and assembly of its CST-100 spacecraft, which is under development in collaboration with NASA's Commercial Crew Program. During his tour, Bolden announced that Space Exploration Technologies, or SpaceX, has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability CCiCap initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

  8. ACHP | News

    Science.gov Websites

    action on the following subjects: Building a More Inclusive National Preservation Program Rightsizing Landscapes Action Plan Announcement of five new Preserve America Community designations Federal Budget

  9. Specialty distribution of physician assistants and nurse practitioners in North Carolina.

    PubMed

    Fraher, Erin P; Morgan, Perri; Johnson, Anna

    2016-04-01

    Physician workforce projections often include scenarios that forecast physician shortages under different assumptions about the deployment of physician assistants (PAs) and nurse practitioners (NPs). These scenarios generally assume that PAs and NPs are an interchangeable resource and that their specialty distributions do not change over time. This study investigated changes in PA and NP specialty distribution in North Carolina between 1997 and 2013. The data show that over the study period, PAs and NPs practiced in a wide range of specialties, but each profession had a specific pattern. The proportion of PAs-but not NPs-reporting practice in primary care dropped significantly. PAs were more likely than NPs to report practice in urgent care, emergency medicine, and surgical subspecialties. Physician workforce models need to account for the different and changing specialization trends of NPs and PAs.

  10. Comparing oncologist, nurse, and physician assistant attitudes toward discussions of negative emotions with patients.

    PubMed

    Morgan, Perri A; de Oliveira, Justine Strand; Alexander, Stewart C; Pollak, Kathryn I; Jeffreys, Amy S; Olsen, Maren K; Olson, Maren K; Arnold, Robert M; Abernethy, Amy P; Rodriguez, Keri L; Rodrigues, Keri L; Tulsky, James A

    2010-01-01

    Although research shows that empathic communication improves patient outcomes, physicians often fail to respond empathically to patients. Nurses and physician assistants (PAs) may be able to help fill the need for empathic communication. Our study compares the attitudes of oncologists, nurses, and PAs toward communication with patients who demonstrate negative emotions. We analyzed surveys from 48 oncologists, 26 PAs, and 22 nurses who participated in the Studying Communication in Oncologist-Patient Encounters trial. Surveys included previously validated items that examined attitudes toward communication with patients about emotion. The mean age of oncology physicians was higher (49 years) than that of PAs (40 years) or nurses (43 years), and 19% of physicians, 81% of PAs, and 100% of nurses were female. Race, years of oncology experience, and previous communication training were similar across provider types. Most nurses (82%) and PAs (68%) described themselves as having a socioemotional orientation, while most oncologists (70%) reported a technological/scientific orientation (p < .0001). PAs and nurses indicated more comfort with psychosocial talk than did oncologists (p < .0001). Discomfort with disclosing uncertainty and provider confidence and expectations when addressing patient concerns were similar across provider types. PAs and nurses were more oriented toward socioemotional aspects of medicine and were more comfortable with psychosocial talk than were oncologists. Future studies should examine whether these differences are attributable to other factors, including gender, and whether nurses and PAs are more likely than physicians to demonstrate empathic behaviors when patients express negative emotions.

  11. Induction of cortical plasticity for reciprocal muscles by paired associative stimulation

    PubMed Central

    Suzuki, Makoto; Kirimoto, Hikari; Sugawara, Kazuhiro; Watanabe, Makoto; Shimizu, Shinobu; Ishizaka, Ikuyo; Yamada, Sumio; Matsunaga, Atsuhiko; Fukuda, Michinari; Onishi, Hideaki

    2014-01-01

    Background Paired associative stimulation (PAS) is widely used to induce plasticity in the human motor cortex. Although reciprocal inhibition of antagonist muscles plays a fundamental role in human movements, change in cortical circuits for reciprocal muscles by PAS is unknown. Methods We investigated change in cortical plasticity for reciprocal muscles during PAS. PAS consisted of 200 pairs of peripheral electric stimulation of the right median nerve at the wrist at a frequency of 0.25 Hz followed by transcranial magnetic stimulation of the left M1 at the midpoint between the center of gravities of the flexor carpi radialis (FCR) and extensor carpi radialis (ECR) muscles. Measures of motor cortical excitability included resting motor threshold (RMT), GABAA-mediated short-interval intracortical inhibition (SICI), and GABAB-mediated long-interval intracortical inhibition (LICI). Results Motor evoked potential amplitude-conditioned LICI for the FCR muscle was significantly decreased after PAS (P = 0.020), whereas that for the ECR muscle was significantly increased (P = 0.033). Changes in RMT and SICI for the FCR and ECR muscles were not significantly different before and after PAS. Corticospinal excitability for both reciprocal muscles was increased during PAS, but GABAB-mediated cortical inhibitory functions for the agonist and antagonist muscles were reciprocally altered after PAS. Conclusion These results implied that the cortical excitability for reciprocal muscles including GABAB-ergic inhibitory systems within human M1 could be differently altered by PAS. PMID:25365805

  12. Tailoring peptide amphiphiles and their assemblies for biomedical applications

    NASA Astrophysics Data System (ADS)

    Lin, Brian

    Peptide amphiphiles (PAs) are molecules composed of a peptide conjugated to a hydrophobic moiety, commonly a fatty acid. They closely resemble the structure of naturally occurring lipopeptides, produced by microbes as signaling and antimicrobial agents. The amphiphilic nature of PAs in concert with the large number of discovered functional peptides inspired scientists to exploit this molecular architecture for producing synthetic self-assembled bioactive materials. PA assemblies are sought after for a wide breadth of applications including disease therapy, regenerative medicine, and catalysis. However, with PAs, the peptide chemistry is a double-edged sword. The peptide component contributes significantly to both the activity and self-assembly. The physiochemical properties of different PAs lead to unique aggregation stability and morphological characteristics which are unpredictable, a priori. Therefore it is challenging to design bioactive PAs and control their self-assembly, simultaneously. This limitation slows the development of PAs for medical use. In this dissertation, methods to control the self-assembly of PAs and the effects of acylating a functional peptide will be discussed. In one part, efforts to direct the self-assembly of PAs into small spherical aggregates, a morphology infrequently observed, will be described. In another section, a strategy to control the stability of PA assemblies will be discussed. In the last section, a pH-responsive membrane perturbing peptide was modified with fatty acid tails and the properties of the resulting PAs will be presented. This dissertation provides some fundamental insight for the use and design of PA self-assemblies.

  13. Physician-Assisted Suicide: Considering the Evidence, Existential Distress, and an Emerging Role for Psychiatry.

    PubMed

    Gopal, Abilash A

    2015-06-01

    Physician-assisted suicide (PAS) is one of the most provocative topics facing society today. Given the great responsibility conferred on physicians by recent laws allowing PAS, a careful examination of this subject is warranted by psychiatrists and other specialists who may be consulted during a patient's request for PAS. In this article, recent evidence regarding the implementation of PAS in the United States and The Netherlands is reviewed. Support is found for some concerns about PAS, such as the possibility that mental illness occurs at higher rates in patients requesting PAS, but not for other concerns, such as the fear that PAS will be practiced more frequently on vulnerable populations (the slippery-slope argument). These data and common arguments for and against PAS are discussed with an emphasis on the tension between values, such as maximizing patient autonomy and adhering to professional obligations, as well as the need for additional research that focuses more directly on the patient-centered perspective. Implications of the available evidence are discussed and lead to a consideration of mental anguish in terminally ill patients including aspects of existential distress and an acknowledgment of the importance of tailoring end-of-life care to the distinct set of values and experiences that shape each patient's perspective. The article concludes with a discussion of an expanding role for psychiatrists in evaluating patients who request PAS. © 2015 American Academy of Psychiatry and the Law.

  14. Paired associative stimulation induces change in presynaptic inhibition of Ia terminals in wrist flexors in humans.

    PubMed

    Lamy, Jean-Charles; Russmann, Heike; Shamim, Ejaz A; Meunier, Sabine; Hallett, Mark

    2010-08-01

    Enhancements in the strength of corticospinal projections to muscles are induced in conscious humans by paired associative stimulation (PAS) to the motor cortex. Although most of the previous studies support the hypothesis that the increase of the amplitude of motor evoked potentials (MEPs) by PAS involves long-term potentiation (LTP)-like mechanism in cortical synapses, changes in spinal excitability after PAS have been reported, suggestive of parallel modifications in both cortical and spinal excitability. In a first series of experiments (experiment 1), we confirmed that both flexor carpi radialis (FCR) MEPs and FCR H reflex recruitment curves are enhanced by PAS. To elucidate the mechanism responsible for this change in the H reflex amplitude, we tested, using the same subjects, the hypothesis that enhanced H reflexes are caused by a down-regulation of the efficacy of mechanisms controlling Ia afferent discharge, including presynaptic Ia inhibition and postactivation depression. To address this question, amounts of both presynaptic Ia inhibition of FCR Ia terminals (D1 and D2 inhibitions methods; experiment 2) and postactivation depression (experiment 3) were determined before and after PAS. Results showed that PAS induces a significant decrease of presynaptic Ia inhibition of FCR terminals, which was concomitant with the facilitation of the H reflex. Postactivation depression was unaffected by PAS. It is argued that enhancement of segmental excitation by PAS relies on a selective effect of PAS on the interneurons controlling presynaptic inhibition of Ia terminals.

  15. 78 FR 45253 - National Toxicology Program Scientific Advisory Committee on Alternative Toxicological Methods...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... Scientific Advisory Committee on Alternative Toxicological Methods; Announcement of Meeting; Request for... Toxicological Methods (SACATM). SACATM advises the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Toxicology Program (NTP) Interagency Center for the Evaluation of...

  16. 75 FR 50007 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... DEPARTMENT OF LABOR Employment and Training Administration Request for Certification of Compliance--Rural Industrialization Loan and Grant Program AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration is issuing this notice to announce...

  17. 75 FR 54655 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... DEPARTMENT OF LABOR Employment and Training Administration Request for Certification of Compliance--Rural Industrialization Loan and Grant Program AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration is issuing this notice to announce...

  18. 75 FR 50006 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... DEPARTMENT OF LABOR Employment and Training Administration Request for Certification of Compliance--Rural Industrialization Loan and Grant Program AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration is issuing this notice to announce...

  19. 78 FR 37584 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... DEPARTMENT OF LABOR Employment and Training Administration Request for Certification of Compliance--Rural Industrialization Loan and Grant Program AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration is issuing this notice to announce...

  20. 78 FR 53466 - Announcement of Funding Awards for Transformation Initiative: Sustainable Communities Research...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... Awards for Transformation Initiative: Sustainable Communities Research Grant (SCRGP) Program for Fiscal Year 2013 AGENCY: Office of the Assistant Secretary of Policy Development and Research, HUD. ACTION... Fiscal Year (FY) 2013 Transformative Initiative: Sustainable Communities Research Grant Program (SCRGP...

  1. 78 FR 71619 - Medicare and Medicaid Programs; Continued Approval of American Osteopathic Association/Healthcare...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services [CMS-3285-FN] Medicare and Medicaid Programs; Continued Approval of American Osteopathic Association/Healthcare... Medicare & Medicaid Services, HHS. ACTION: Final notice. SUMMARY: This final notice announces our decision...

  2. 76 FR 28625 - Sorghum Promotion, Research, and Information Program; State Referendum Results

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ..., Research, and Information Program; State Referendum Results AGENCY: Agricultural Marketing Service, USDA. ACTION: Announcement of referendum results. SUMMARY: The Agricultural Marketing Service (AMS) is... the period July 1, 2008, through Dec. 31, 2010. Therefore, based on the referendum results, the...

  3. 77 FR 61433 - Proposal Review Panel for Materials Research; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Materials Research; Notice of Meeting In... Foundation announces the following meeting: Name: Site visit review of the Materials Research Science and..., Program Director, Materials Research Science and Engineering Centers Program, Division of Materials...

  4. Voluntary program to reduce soot

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-01-01

    The U.S. Environmental Protection Agency (EPA) announced on 17 January that it has formulated a voluntary clean air program, Particulate Matter (PM) Advance, to help communities develop strategies to reduce fine-particle emissions, often called soot or particulate matter, that can be harmful to human health.

  5. 77 FR 2095 - Proposal Review Panel for Materials Research; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Materials Research; Notice of Meeting In... Foundation announces the following meeting: Name: Site visit review of the Materials Research Science and... Person: Dr. Thomas Rieker, Program Director, Materials Research Science and Engineering Centers Program...

  6. 77 FR 27252 - Veterans' Employment and Training; Veterans Workforce Investment Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... DEPARTMENT OF LABOR Veterans' Employment and Training; Veterans Workforce Investment Program AGENCY: Veterans' Employment and Training Service, Department of Labor. Announcement Type: New Notice of... applications is June 15, 2012. Funding Opportunity Description The U.S. Department of Labor (USDOL), Veterans...

  7. 77 FR 6826 - Proposal Review Panel for Materials Research; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Materials Research; Notice of Meeting In... Foundation announces the following meeting: Name: Site visit review of the Materials Research Science and..., Program Director, Materials Research Science and Engineering Centers Program, Division of Materials...

  8. 77 FR 25503 - Proposal Review Panel for Materials Research; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Materials Research; Notice of Meeting In... Foundation announces the following meeting: Name: Site visit review of the Materials Research Science and...: Dr. Sean L. Jones, Program Director, Materials Research Science and Engineering Centers Program...

  9. 78 FR 5505 - Proposal Review Panel for Materials Research; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Materials Research; Notice of Meeting In... Foundation announces the following meeting: Name: Site Visit review of the Materials Research Science and.... Charles Bouldin, Program Director, Materials Research Science and Engineering Centers Program, Division of...

  10. 75 FR 454 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... DEPARTMENT OF LABOR Employment and Training Administration Request for Certification of Compliance--Rural Industrialization Loan and Grant Program AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration is issuing this notice to announce...

  11. Space shuttle and life sciences

    NASA Technical Reports Server (NTRS)

    Mason, J. A.

    1977-01-01

    During the 1980's, some 200 Spacelab missions will be flown on space shuttle in earth-orbit. Within these 200 missions, it is planned that at least 20 will be dedicated to life sciences research, projects which are yet to be outlined by the life sciences community. Objectives of the Life Sciences Shuttle/Spacelab Payloads Program are presented. Also discussed are major space life sciences programs including space medicine and physiology, clinical medicine, life support technology, and a variety of space biology topics. The shuttle, spacelab, and other life sciences payload carriers are described. Concepts for carry-on experiment packages, mini-labs, shared and dedicated spacelabs, as well as common operational research equipment (CORE) are reviewed. Current NASA planning and development includes Spacelab Mission Simulations, an Announcement of Planning Opportunity for Life Sciences, and a forthcoming Announcement of Opportunity for Flight Experiments which will together assist in forging a Life Science Program in space.

  12. Attitudes towards, and wishes for, euthanasia in advanced cancer patients at a palliative medicine unit.

    PubMed

    Johansen, Sissel; Hølen, Jacob Chr; Kaasa, Stein; Loge, Håvard Jon; Materstvedt, Lars Johan

    2005-09-01

    Most studies on attitudes towards euthanasia and physician-assisted suicide (PAS) have been conducted in healthy populations. The aim of this study is to explore and describe attitudes towards, and wishes for, euthanasia/PAS in cancer patients with short life expectancy. Semi-structured interviews with 18 cancer patients with a life expectancy of less than nine months. All patients were recruited from an inpatient palliative medicine unit. Patients holding a positive attitude towards euthanasia/PAS do not necessarily want euthanasia/PAS for themselves. Wishes are different from requests for euthanasia/PAS. Fear of future pain and a painful death were the main reasons given for a possible wish for euthanasia/PAS. Worries about minimal quality of life and lack of hope also contributed to such thoughts. Wishes for euthanasia/PAS were hypothetical; they were future oriented and with a prerequisite that intense pain, lack of quality of life and/or hope had to be present. Additionally, wishes were fluctuating and ambivalent. The wish to die in these patients does not seem to be constant. Rather, this wish is more appropriately seen as an ambivalent and fluctuating mental 'solution' for the future. Health care providers should be aware of this when responding to utterances regarding euthanasia/PAS.

  13. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.

    PubMed

    Zheng, Jun; Rubin, Eric J; Bifani, Pablo; Mathys, Vanessa; Lim, Vivian; Au, Melvin; Jang, Jichan; Nam, Jiyoun; Dick, Thomas; Walker, John R; Pethe, Kevin; Camacho, Luis R

    2013-08-09

    para-Aminosalicylic acid (PAS) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Although it has been in clinical use for over 60 years, its mechanism(s) of action remains elusive. Here we report that PAS is a prodrug targeting dihydrofolate reductase (DHFR) through an unusual and novel mechanism of action. We provide evidences that PAS is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate a hydroxyl dihydrofolate antimetabolite, which in turn inhibits DHFR enzymatic activity. Interestingly, PAS is recognized by DHPS as efficiently as its natural substrate para-amino benzoic acid. Chemical inhibition of DHPS or mutation in DHFS prevents the formation of the antimetabolite, thereby conferring resistance to PAS. In addition, we identified a bifunctional enzyme (riboflavin biosynthesis protein (RibD)), a putative functional analog of DHFR in a knock-out strain. This finding is further supported by the identification of PAS-resistant clinical isolates encoding a RibD overexpression mutation displaying cross-resistance to genuine DHFR inhibitors. Our findings reveal that a metabolite of PAS inhibits DHFR in the folate pathway. RibD was shown to act as a functional analog of DHFR, and as for DHFS, both were shown to be associated in PAS resistance in laboratory strains and clinical isolates.

  14. Concentrations of proanthocyanidins in common foods and estimations of normal consumption.

    PubMed

    Gu, Liwei; Kelm, Mark A; Hammerstone, John F; Beecher, Gary; Holden, Joanne; Haytowitz, David; Gebhardt, Susan; Prior, Ronald L

    2004-03-01

    Proanthocyanidins (PAs) have been shown to have potential health benefits. However, no data exist concerning their dietary intake. Therefore, PAs in common and infant foods from the U.S. were analyzed. On the bases of our data and those from the USDA's Continuing Survey of Food Intakes by Individuals (CSFII) of 1994-1996, the mean daily intake of PAs in the U.S. population (>2 y old) was estimated to be 57.7 mg/person. Monomers, dimers, trimers, and those above trimers contribute 7.1, 11.2, 7.8, and 73.9% of total PAs, respectively. The major sources of PAs in the American diet are apples (32.0%), followed by chocolate (17.9%) and grapes (17.8%). The 2- to 5-y-old age group (68.2 mg/person) and men >60 y old (70.8 mg/person) consume more PAs daily than other groups because they consume more fruit. The daily intake of PAs for 4- to 6-mo-old and 6- to 10-mo-old infants was estimated to be 1.3 mg and 26.9 mg, respectively, based on the recommendations of the American Academy of Pediatrics. This study supports the concept that PAs account for a major fraction of the total flavonoids ingested in Western diets.

  15. Physician-assisted suicide: the legal slippery slope.

    PubMed

    Walker, R M

    2001-01-01

    In Oregon, physicians can prescribe lethal amounts of medication only if requested by competent, terminally ill patients. However, the possibility of extending the practice to patients who lack decisional capacity exists. This paper examines why the legal extension of physician-assisted suicide (PAS) to incapacitated patients is possible, and perhaps likely. The author reviews several pivotal court cases that have served to define the distinctions and legalities among "right-to-die" cases and the various forms of euthanasia and PAS. Significant public support exists for legalizing PAS and voluntary euthanasia in the United States. The only defenses against sliding from PAS to voluntary euthanasia are adhering to traditional physician morality that stands against it and keeping the issue of voluntary euthanasia legally framed as homicide. However, if voluntary euthanasia evolves euphemistically as a medical choice issue, then the possibility of its legalization exists. If courts allow PAS to be framed as a basic personal right akin to the right to refuse treatment, and if they rely on right-to-die case precedents, then they will likely extend PAS to voluntary euthanasia and nonvoluntary euthanasia. This would be done by extending the right to PAS to incapacitated patients, who may or may not have expressed a choice for PAS prior to incapacity.

  16. Physician assistants as servant leaders: meeting the needs of the underserved.

    PubMed

    Huckabee, Michael J; Wheeler, Daniel W

    2011-01-01

    The purpose of this study was to determine if the level of servant leader characteristics in clinically practicing physician assistants (PAs) in underserved populations differed from PAs serving in other locales. Five subscales of servant leadership: altruistic calling, emotional healing, wisdom, persuasive mapping, and organizational stewardship, were measured in a quantitative study of clinically practicing PAs using a self-rating survey and a similar survey by others rating the PA. Of 777 PAs invited, 321 completed the survey. On a scale of 1 to 5, mean PA self-ratings ranged from 3.52 (persuasive mapping) to 4.05 (wisdom). Other raters' scores paired with the self-rated PA scores were comparable in all subscales except wisdom, which was rated higher by the other raters (4.32 by other raters, 4.01 by PAs, P= .002). There was no significant difference in the measures of servant leadership reported by PAs serving the underserved compared to PAs serving in other populations. Servant leader subscales were higher for PAs compared to previous studies of other health care or community leader populations. The results found that the PA population studied had a prominent level of servant leadership characteristics that did not differ between those working with underserved and nonunderserved populations.

  17. Artificial ligand binding within the HIF2[alpha] PAS-B domain of the HIF2 transcription factor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scheuermann, Thomas H.; Tomchick, Diana R.; Machius, Mischa

    2009-05-12

    The hypoxia-inducible factor (HIF) basic helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations. In humans, HIF is critically important for the sustained growth and metastasis of solid tumors. Here, we describe crystal structures of the heterodimer formed by the C-terminal PAS domains from the HIF2{alpha} and ARNT subunits of the HIF2 transcription factor, both in the absence and presence of an artificial ligand. Unexpectedly, the HIF2{alpha} PAS-B domain contains a large internal cavity that accommodates ligands identified frommore » a small-molecule screen. Binding one of these ligands to HIF2{alpha} PAS-B modulates the affinity of the HIF2{alpha}:ARNT PAS-B heterodimer in vitro. Given the essential role of PAS domains in forming active HIF heterodimers, these results suggest a presently uncharacterized ligand-mediated mechanism for regulating HIF2 activity in endogenous and clinical settings.« less

  18. Impact of payments for environmental services and protected areas on local livelihoods and forest conservation in northern Cambodia

    PubMed Central

    Clements, Tom; Milner-Gulland, E J

    2015-01-01

    The potential impacts of payments for environmental services (PES) and protected areas (PAs) on environmental outcomes and local livelihoods in developing countries are contentious and have been widely debated. The available evidence is sparse, with few rigorous evaluations of the environmental and social impacts of PAs and particularly of PES. We measured the impacts on forests and human well-being of three different PES programs instituted within two PAs in northern Cambodia, using a panel of intervention villages and matched controls. Both PES and PAs delivered additional environmental outcomes relative to the counterfactual: reducing deforestation rates significantly relative to controls. PAs increased security of access to land and forest resources for local households, benefiting forest resource users but restricting households’ ability to expand and diversify their agriculture. The impacts of PES on household well-being were related to the magnitude of the payments provided. The two higher paying market-linked PES programs had significant positive impacts, whereas a lower paying program that targeted biodiversity protection had no detectable effect on livelihoods, despite its positive environmental outcomes. Households that signed up for the higher paying PES programs, however, typically needed more capital assets; hence, they were less poor and more food secure than other villagers. Therefore, whereas the impacts of PAs on household well-being were limited overall and varied between livelihood strategies, the PES programs had significant positive impacts on livelihoods for those that could afford to participate. Our results are consistent with theories that PES, when designed appropriately, can be a powerful new tool for delivering conservation goals whilst benefiting local people. El Impacto de los Pagos por Servicios Ambientales y Áreas Protegidas sobre la Subsistencia Local y la Conservación del Bosque en el Norte de Camboya Resumen Los impactos potenciales de los pagos por servicios ambientales (PSA) y áreas protegidas (APs) sobre los resultados ambientales y las subsistencias locales en los países en desarrollo son polémicos y se han debatido ampliamente. La evidencia disponible es escasa; ha habido pocas evaluaciones rigurosas de los impactos ambientales y sociales de las APs y particularmente los PSA. Medimos el impacto sobre los bosques y el bienestar humano en tres diferentes programas de PSA que se llevan a cabo dentro de dos APs en el norte de Camboya usando un panel de aldeas de intervención y controles emparejados. Tanto los PSA como las APs brindaron resultados ambientales adicionales en relación a los contrafácticos, esto quiere decir que redujeron las tasas de deforestación significativamente en relación a los controles. Las áreas protegidas incrementaron el acceso seguro a los recursos del suelo y el bosque para las viviendas locales, beneficiando a los usuarios de los recursos del bosque pero restringiendo la habilidad de las viviendas para expandirse y diversificar su agricultura. Los impactos de los pagos por servicios ambientales sobre el bienestar de las viviendas estuvieron relacionados con la magnitud de los pagos proporcionados. Los dos programas de PSA de mayor paga y con conexión al mercado tuvieron impactos positivos significativos, mientras que un programa de menor paga con el objetivo de proteger a la biodiversidad no tuvo un efecto detectable sobre las viviendas, a pesar de sus resultados ambientales positivos. Las viviendas que se inscribieron a los programas de PSA con mayor paga, sin embargo, necesitaban típicamente más bienes capitales, por lo que eran menos pobres y tenían mayor seguridad alimentaria que otros aldeanos. Por esto, mientras los impactos de las APs sobre el bienestar de las viviendas fueron limitados en general y variaron dependiendo de las estrategias de subsistencia, los programas de PSA tuvieron impactos positivos significativos sobre las viviendas para aquellos que podían costear participar. Nuestros resultados son congruentes con las teorías de que los PSA, cuando se designan apropiadamente, pueden ser una herramienta poderosa y novedosa para obtener objetivos de conservación mientras se beneficia a la gente local. PMID:25492724

  19. 75 FR 62399 - Public Meeting To Solicit Input for a Strategic Plan for Federal Youth Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... that the Interagency Working Group on Youth Programs solicit input from young people, State children's... Services, in its role as the Chair of the Interagency Working Group on Youth Programs, is announcing a... site for the Interagency Working Group on Youth Programs at http://www.FindYouthInfo.gov for...

  20. 75 FR 48690 - Public Meeting To Solicit Input for a Strategic Plan for Federal Youth Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... directing the Interagency Working Group on Youth Programs to solicit input from young people, State children... Services, in its role as the Chair of the Interagency Working Group on Youth Programs, is announcing a... site for the Interagency Working Group on Youth Programs at http://www.FindYouthInfo.gov for...

  1. 76 FR 64388 - Advisory Committee for Polar Programs; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... NATIONAL SCIENCE FOUNDATION Advisory Committee for Polar Programs; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation announces the following meeting: Name: Advisory Committee for Polar Programs (1130). Date/Time: November 14, 2011, 8:30 a.m. to 5:30 p.m.; November 15...

  2. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, announce to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  3. 76 FR 78300 - Announcement of Funding Awards for Notice of Funding Availability (NOFA) for HUD's Fiscal Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Mortgage Scams Assistance Housing Counseling Under the Housing Counseling Program AGENCY: Office of the... Counseling Program. SUMMARY: In accordance with section 102(a)(4)(C) of the Department of Housing and Urban... recipients under the Housing Counseling Program. FOR FURTHER INFORMATION CONTACT: Ruth Rom[aacute]n, Director...

  4. Implementing Inclusion and Collaborative Teaming in a Model Program of Postsecondary Education for Young Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Folk, Eric D. R.; Yamamoto, Kathryn K.; Stodden, Robert A.

    2012-01-01

    In 2010, the U.S. Department of Education announced an initiative to improve transitioning to postsecondary education (PSE) for individuals with intellectual disabilities (ID) by funding the model comprehensive Transition and Postsecondary Programs for Students with Intellectual Disabilities (TPSID) program. The TPSID provides for grants to create…

  5. 78 FR 25291 - Announcement of Funding Awards; Section 3 Program Coordination and Implementation; Fiscal Year 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... funding under the Notice of Funding Availability (NOFA) for the Section 3 Program Coordination and.... (The Catalog of Federal Domestic Assistance Number for currently funded Initiatives under the Section 3... Valentine Reid, 816-777-2390. 7 50,000.00 East Armour Boulevard, Jackson, MO 64112-1254. Section 3 Program...

  6. 77 FR 45380 - Announcement Regarding States Triggering “On” and “Off” in the Emergency Unemployment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Triggering ``On'' and ``Off'' in the Emergency Unemployment Compensation 2008 (EUC08) Program and the Federal... Unemployment Compensation 2008 (EUC08) Program and the Federal-State Extended Benefits (EB) Program. The U.S... Statistics on June 15, 2012, the three month average, seasonally adjusted total unemployment rate for Nevada...

  7. Small Business Innovation Research (SBIR) Program, FY 1993. Program Solicitation 93.1, Closing Date: 15 January 1993

    DTIC Science & Technology

    1992-01-01

    tactical computers. The module must correct for optical irregularities in illumination, pixel gain, offset nonuniformities due to dark currents and...large search FOR, for IR FPA. DESCRIPTION: Large area staring IR lPAs in both Medium Wavelength Infrared (MWIR) and Long Wavelength Infrared ( LWIR ) are a...of HTS materials to BLIP limited detection of radiation in the optical, IR, MWIR, and LWIR bands as well as for signal processing applications is also

  8. Effect of CME on Primary Care and OB/GYN Treatment of Breast Masses

    ERIC Educational Resources Information Center

    Price, David W.; Xu, Stanley; McClure, David

    2005-01-01

    Introduction: CME program planners are being asked to move beyond assessments of knowledge to assessing the impact of CME on practice and patient outcomes. Methods: We conducted a pre-post analysis of administrative data from 107 physicians, nurse practitioners (NPs), or physician's assistants (PAs) who attended one or two continuing medical…

  9. Effectiveness of a Shortened, Clinically Engaged Anatomy Course for Physician Assistant Students

    ERIC Educational Resources Information Center

    Rizzolo, Lawrence J.; Rando, William C.; O'Brien, Michael K.; Garino, Alexandria; Stewart, William B.

    2011-01-01

    There is little consensus among programs that train physician assistants (PAs) regarding how much time should be devoted to the study of anatomy, what should be included, or how it should be taught. Similar concerns led us to redesign anatomy for medical students and introduce clinically engaged anatomy, an approach designed in collaboration with…

  10. Adapting environmental function analysis for management of protected areas in small islands--case of Pico Island (the Azores).

    PubMed

    Calado, Helena; Bragagnolo, Chiara; Silva, Susana; Vergílio, Marta

    2016-04-15

    Protected areas (PAs) are considered key priorities for ensuring long-term sustainability of small islands. The traditional approach of conservation versus development is currently being replaced by an approach of "win-win" relationships. During the last decades PAs have been increasingly requested to simultaneously ensure biodiversity conservation, mainstream ecosystem services into main development policies, and accounting for leisure-related revenues to sustain local and regional economies. Following this new paradigm, the Smartparks project (Planning and Management System for Small Islands Protected Areas), encompassing this study, aimed at an innovative approach for supporting the management of PAs in small islands. In this study, we propose a methodology based on Environmental Functional Analyses (EFA) to compare the potential for conservation and the potential for use of PAs that can be used not only on small islands but also in other territories. For this purpose, a set of environmental and socio-economic components was defined and selected indicators describing each component to calculate conservation and use/development functions of PAs were established. Pico Island, in the Azores archipelago (Portugal), was selected as the case study for testing the methodology. The EFA for all PAs of Pico Island was performed identifying those with more potential for conservation or for development of human activities, and also those with high levels of conflict. A total of 34 indicators was applied (assigning a value from 1 to 3) to the 22 PAs composing the INP of Pico Island: 44% were scored with a value of 1, in both ecological and social components; 22% and 29% were scored 3 in ecological and social components respectively. Social indicators were generally considered less important than environmental ones. In general, PAs presented higher values for conservation. The results further show that the potential for conservation and/or development was consistent with the IUCN category and the objectives assigned to each PA at the time of its classification. However, most PAs are located in the conflict zone of the EFA matrix, revealing a high interaction between PAs conservation objectives and human activities, which brings concern to decision makers and PAs managers. Despite several limitations, the method allowed the performances of PAs to be compared, providing a suitable tool to support rapid assessments and monitoring of PA networks in small islands. The adaptation of the EFA to the PA domain traces a new path for estimating the multiple values of PAs and it may contribute to improve PA management and decision-making. The method could be further included as part of scenario exercise and adaptive management, supporting the prediction of the future evolution of PAs and assessing their potential for conservation in the future throughout the proposed indicators. Thus, the methodology is not exclusive for small islands contexts and, with necessary adaptations and rescaling, it could be a powerful tool in PAs network management worldwide. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Wildlife population trends in protected areas predicted by national socio-economic metrics and body size

    PubMed Central

    Barnes, Megan D.; Craigie, Ian D.; Harrison, Luke B.; Geldmann, Jonas; Collen, Ben; Whitmee, Sarah; Balmford, Andrew; Burgess, Neil D.; Brooks, Thomas; Hockings, Marc; Woodley, Stephen

    2016-01-01

    Ensuring that protected areas (PAs) maintain the biodiversity within their boundaries is fundamental in achieving global conservation goals. Despite this objective, wildlife abundance changes in PAs are patchily documented and poorly understood. Here, we use linear mixed effect models to explore correlates of population change in 1,902 populations of birds and mammals from 447 PAs globally. On an average, we find PAs are maintaining populations of monitored birds and mammals within their boundaries. Wildlife population trends are more positive in PAs located in countries with higher development scores, and for larger-bodied species. These results suggest that active management can consistently overcome disadvantages of lower reproductive rates and more severe threats experienced by larger species of birds and mammals. The link between wildlife trends and national development shows that the social and economic conditions supporting PAs are critical for the successful maintenance of their wildlife populations. PMID:27582180

  12. Designing universal primers for the isolation of DNA sequences encoding Proanthocyanidins biosynthetic enzymes in Crataegus aronia

    PubMed Central

    2012-01-01

    Background Hawthorn is the common name of all plant species in the genus Crataegus, which belongs to the Rosaceae family. Crataegus are considered useful medicinal plants because of their high content of proanthocyanidins (PAs) and other related compounds. To improve PAs production in Crataegus tissues, the sequences of genes encoding PAs biosynthetic enzymes are required. Findings Different bioinformatics tools, including BLAST, multiple sequence alignment and alignment PCR analysis were used to design primers suitable for the amplification of DNA fragments from 10 candidate genes encoding enzymes involved in PAs biosynthesis in C. aronia. DNA sequencing results proved the utility of the designed primers. The primers were used successfully to amplify DNA fragments of different PAs biosynthesis genes in different Rosaceae plants. Conclusion To the best of our knowledge, this is the first use of the alignment PCR approach to isolate DNA sequences encoding PAs biosynthetic enzymes in Rosaceae plants. PMID:22883984

  13. Designing universal primers for the isolation of DNA sequences encoding Proanthocyanidins biosynthetic enzymes in Crataegus aronia.

    PubMed

    Zuiter, Afnan Saeid; Sawwan, Jammal; Al Abdallat, Ayed

    2012-08-10

    Hawthorn is the common name of all plant species in the genus Crataegus, which belongs to the Rosaceae family. Crataegus are considered useful medicinal plants because of their high content of proanthocyanidins (PAs) and other related compounds. To improve PAs production in Crataegus tissues, the sequences of genes encoding PAs biosynthetic enzymes are required. Different bioinformatics tools, including BLAST, multiple sequence alignment and alignment PCR analysis were used to design primers suitable for the amplification of DNA fragments from 10 candidate genes encoding enzymes involved in PAs biosynthesis in C. aronia. DNA sequencing results proved the utility of the designed primers. The primers were used successfully to amplify DNA fragments of different PAs biosynthesis genes in different Rosaceae plants. To the best of our knowledge, this is the first use of the alignment PCR approach to isolate DNA sequences encoding PAs biosynthetic enzymes in Rosaceae plants.

  14. Wildlife population trends in protected areas predicted by national socio-economic metrics and body size

    NASA Astrophysics Data System (ADS)

    Barnes, Megan D.; Craigie, Ian D.; Harrison, Luke B.; Geldmann, Jonas; Collen, Ben; Whitmee, Sarah; Balmford, Andrew; Burgess, Neil D.; Brooks, Thomas; Hockings, Marc; Woodley, Stephen

    2016-09-01

    Ensuring that protected areas (PAs) maintain the biodiversity within their boundaries is fundamental in achieving global conservation goals. Despite this objective, wildlife abundance changes in PAs are patchily documented and poorly understood. Here, we use linear mixed effect models to explore correlates of population change in 1,902 populations of birds and mammals from 447 PAs globally. On an average, we find PAs are maintaining populations of monitored birds and mammals within their boundaries. Wildlife population trends are more positive in PAs located in countries with higher development scores, and for larger-bodied species. These results suggest that active management can consistently overcome disadvantages of lower reproductive rates and more severe threats experienced by larger species of birds and mammals. The link between wildlife trends and national development shows that the social and economic conditions supporting PAs are critical for the successful maintenance of their wildlife populations.

  15. 78 FR 76628 - Pilot Program for Parallel Review of Medical Products; Extension of the Duration of the Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ...The Food and Drug Administration (FDA) and the Centers for Medicare and Medicaid Services (CMS) (the Agencies) are announcing the extension of the ``Pilot Program for Parallel Review of Medical Products.'' The Agencies have decided to continue the program as currently designed for an additional period of 2 years from the date of publication of this notice.

  16. The enhanced forest inventory and analysis program of the USDA forest service: historical perspective and announcements of statistical documentation

    Treesearch

    Ronald E. McRoberts; William A. Bechtold; Paul L. Patterson; Charles T. Scott; Gregory A. Reams

    2005-01-01

    The Forest Inventory and Analysis (FIA) program of the USDA Forest Service has initiated a transition from regional, periodic inventories to an enhanced national FIA program featuring annual measurement of a proportion of plots in each state, greater national consistency, and integration with the ground sampling component of the Forest Health Monitoring (FHM) program...

  17. 77 FR 4616 - Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FM) announces its findings on...

  18. 75 FR 34516 - Bureau of Educational and Cultural Affairs; Edmund S. Muskie Graduate Fellowship Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    .... Muskie Graduate Fellowship Program Notice: Correction to original Request for Grant Proposals. SUMMARY... revision to the original Request for Grant Proposals (RFGP) for the Edmund S. Muskie Graduate Fellowship... the original announcement remain the same. Additional Information Interested organizations should...

  19. 75 FR 10492 - Tribal Self-Governance Program; Negotiation Cooperative Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ...-2010-IHS-TSGN-0001] Tribal Self-Governance Program; Negotiation Cooperative Agreement Announcement Type... Description The purpose of the Negotiation Cooperative Agreement is to provide resources to Tribes interested... Negotiation Cooperative Agreement provides a Tribe with funds to help cover the expenses involved in preparing...

  20. 75 FR 11836 - Bioenergy Program for Advanced Biofuels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... (NOCP); additional payment for advanced biofuel produced from October 1, 2008 through September 30, 2009. SUMMARY: RBS is announcing additional payments to advanced biofuel producers determined eligible in Fiscal... biofuel produced in FY 2009, the request must include: Form RD 9005-3, ``Advanced Biofuel Program Payment...

  1. 76 FR 64043 - Iowa Regulatory Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement 30 CFR Part 915 [Docket No. IA-016-FOR; Docket ID: OSM-2011-0014] Iowa Regulatory Program AGENCY: Office of Surface Mining.... SUMMARY: We, the Office of Surface Mining Reclamation and Enforcement (OSM), are announcing receipt of a...

  2. 77 FR 48592 - Bus and Bus Facilities Discretionary Program Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... to award the funds for capital investments aimed at replacing or rehabilitating transit... (DOT) Federal Transit Administration (FTA) announces the selection of capital projects for the State of... Facilities Program funds. As outlined in the NOFA, the Section 5309 funds would be awarded for capital...

  3. 75 FR 48411 - Noise Compatibility Program Notice; Fort Worth Alliance Airport, Fort Worth, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Noise Compatibility Program Notice.... SUMMARY: The Federal Aviation Administration (FAA) announces that it is reviewing a proposed noise... et seq. (the Aviation Safety and Noise Abatement Act, hereinafter referred to as ``the Act'') and 14...

  4. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Scott J. Horowitz, NASA Associate Administrator for Exploration Systems, announces to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  5. 20 CFR 632.256 - Submission of applications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

  6. 20 CFR 632.256 - Submission of applications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

  7. 20 CFR 632.256 - Submission of applications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

  8. 76 FR 23331 - Outer Continental Shelf (OCS) Scientific Committee (SC); Announcement of Plenary Session

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ...., biology/ecology, physical sciences, and social sciences) to review the specific studies plans of the... Studies Program, Environmental Division, Bureau of Ocean Energy Management, Regulation and Enforcement... feasibility, appropriateness, and scientific value of the OCS Environmental Studies Program to the Secretary...

  9. 78 FR 66364 - Medicare & Medicaid Programs: Application From the Accreditation Commission for Health Care for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ...] Medicare & Medicaid Programs: Application From the Accreditation Commission for Health Care for Continued... Accreditation Commission for Health Care (ACHC) for continued recognition as a national accrediting organization...) announcing Accreditation Commission for Health Care's request for approval of its hospice accreditation...

  10. 77 FR 24227 - Proposal Review Panel for Social and Economic Sciences; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... Kronz, Program Director; Science, Technology and Society Program; Division of Social and Economic... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Social and Economic Sciences; Notice of... Science Foundation announces the following meeting: Name: Site visit review of the Nanoscale Science and...

  11. 77 FR 24228 - Proposal Review Panel for Social and Economic Sciences; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... open. Contact Person: Dr. Frederick Kronz, Program Director; Science, Technology, and Society Program... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Social and Economic Sciences; Notice of... Science Foundation announces the following meeting: Name: Site visit review of the Nanoscale Science and...

  12. 78 FR 55338 - ITS Joint Program Office; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration ITS Joint Program Office; Notice of Meeting AGENCY: Research and Innovative Technology Administration (RITA), U.S. Department of Transportation. ACTION: Notice. This notice announces the cancellation of the Connected Vehicle Planning and Policy Stakeholder Meeting. Th...

  13. 77 FR 50110 - Medicare Program; Request for Nominations for Members for the Medicare Evidence Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ...] Medicare Program; Request for Nominations for Members for the Medicare Evidence Development & Coverage... notice announces the request for nominations for membership on the Medicare Evidence Development... Centers for Medicare & Medicaid Services (CMS) concerning the adequacy of scientific evidence available to...

  14. 76 FR 71958 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... Security Education Program, DoD. ACTION: Notice. SUMMARY: In compliance with Section 3506(c)(2)(A) of the.../National Security Education Program announces the proposed extension of a public information collection and... burden of the proposed information collection; (c) ways to enhance the quality, utility, and clarity of...

  15. Non-physician providers as clinical providers in cystic fibrosis: survey of U.S. programs.

    PubMed

    Brown, Rebekah F; Willey-Courand, Donna Beth; George, Cindy; McMullen, Ann; Dunitz, Jordan; Slovis, Bonnie; Perkett, Elizabeth

    2013-04-01

    Non-physician providers (NPPs) including nurse practitioners (NPs) and physician assistants (PAs) are important members of CF care teams, but limited data exist about the extent NPPs are involved in CF care. A subcommittee was established by the CF Foundation to gather information about current involvement of NPPs. Surveys were sent to adult, pediatric and affiliate CF program directors (PDs) and NPPs working in US CF programs. Responses were received from 108 PDs (49% pediatric, 34% adult, 17% affiliate). Overall, 53% of the 108 programs had NPPs and 70% had or planned to hire NPPs. Reasons for NPP use included ideal clinical role (75%), expansion of services (72%), and physician shortage (40%). The survey collected 73 responses from NPPs (96% NPs, 4% PAs) who worked in pediatric (49%), adult (29%), affiliate (3%), or multiple programs (19%). Training occurred on the job in 88% and from prior CF experience in 21%. NPPs provided coverage in outpatient clinics (82%), inpatient care (64%), and weekend and/or night call (22%). In addition to clinical roles, NPPs are involved in education (95%), research (81%), and leadership (55%). The major obstacle reported by PDs and NPPs was billing with only 12% of programs reporting NPP salaries covered by billing revenue alone. Salary support included hospital support (67%), billing (39%), center grant (35%), and other grant/contract (25%). NPPs bill for outpatient and inpatient care in 65% and 28% of programs, respectively. NPPs are working with physicians in many centers and have the potential to help meet the increasing clinical workforce demands. Further evaluation of financial issues is indicated to continue the support of NPP jobs in CF. Roles and expectations need to be clearly defined. Initial and ongoing training standards and opportunities should be explored. Copyright © 2012 Wiley Periodicals, Inc.

  16. Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study.

    PubMed

    Zielske, Joerg; Bohne, Silvia; Brunkhorst, Frank M; Axer, Hubertus; Guntinas-Lichius, Orlando

    2014-11-01

    Dysphagia is a major risk factor for morbidity and mortality in critically ill patients treated in intensive care units (ICUs). Structured otorhinolaryngological data on dysphagia in ICU survivors with severe sepsis are missing. In a prospective study, 30 ICU patients with severe sepsis and thirty without sepsis as control group were examined using bedside fiberoptic endoscopic evaluation of swallowing after 14 days in the ICU (T1) and 4 months after onset of critical illness (T2). Swallowing dysfunction was assessed using the Penetration-Aspiration Scale (PAS). The Functional Oral Intake Scale was applied to evaluate the diet needed. Primary endpoint was the burden of dysphagia defined as PAS score >5. At T1, 19 of 30 severe sepsis patients showed aspiration with a PAS score >5, compared to 7 of 30 in critically ill patients without severe sepsis (p = 0.002). Severe sepsis and tracheostomy were independent risk factors for severe dysphagia with aspiration (PAS > 5) at T1 (p = 0.042 and 0.006, respectively). 4-month mortality (T2) was 57 % in severe sepsis patients compared to 20 % in patients without severe sepsis (p = 0.006). At T2, more severe sepsis survivors were tracheostomy-dependent and needed more often tube or parenteral feeding (p = 0.014 and p = 0.040, respectively). Multivariate analysis revealed tracheostomy at T1 as independent risk factor for severe dysphagia at T2 (p = 0.030). Severe sepsis appears to be a relevant risk factor for long-term dysphagia. An otorhinolaryngological evaluation of dysphagia at ICU discharge is mandatory for survivors of severe critical illness to plan specific swallowing rehabilitation programs.

  17. Why do we lose protected areas? Factors influencing protected area downgrading, downsizing and degazettement in the tropics and subtropics.

    PubMed

    Symes, William S; Rao, Madhu; Mascia, Michael B; Carrasco, L Roman

    2016-02-01

    Protected areas (PAs) are an essential tool for the conservation of biodiversity globally. Previous studies have focussed on the effectiveness of PAs and the design of optimal PA networks. However, not all PAs remain intact permanently; many PAs undergo downgrading, downsizing and/or degazettement (PADDD), a fact largely ignored until recently. The drivers of enacted PADDD events and the factors influencing its spatial occurrence are poorly understood, potentially undermining the efficacy of PAs and PA networks. Here we examine the spatial relationship between PADDD and economic, demographic and structural variables, using a 110-year data set of 342 enacted PADDD events across 44 countries in the tropics and subtropics. We find that the probability of an enacted PADDD event increases with the size of the PA and through a synergistic interaction between PA size and local population densities. Our results are robust to the under-reporting of enacted PADDD events that occur among smaller PAs and in regions with lower population density. We find an economic motive for PADDD events, given that the opportunity costs associated with larger PAs are higher, on average, than smaller PAs. Our findings suggest a need for conservation practitioners to better consider PA characteristics, as well as the social, economic and political context in which PAs are situated, to aid the creation of more efficient and sustainable PA networks. In particular, the dynamics of enacted PADDD events highlight the need to explicitly consider PA robustness as a core component of systematic conservation planning for PA networks. © 2015 John Wiley & Sons Ltd.

  18. The effects of paired associative stimulation on knee extensor motor excitability of individuals post-stroke: A pilot study

    PubMed Central

    Rogers, Lynn M.; Brown, David A.; Stinear, James W.

    2012-01-01

    Objective Paired associative stimulation (PAS) modulates bilateral distal lower limb motor pathways during walking. We assessed the effects of inhibitory PAS applied to the vastus medialis (VM) motor pathways of chronic stroke patients. Methods PAS consisted of 120 electrical stimuli applied to the femoral nerve paired with transcranial magnetic stimulation (TMS) of the lower limb primary motor cortex so that the estimated arrival of the afferent volley occurred 8 ms after delivery of the magnetic stimulus. Stimulus pairs were delivered to the non-paretic VM motor system of 11 chronic stroke patients and the right limb motor system of 11 non-impaired subjects at 0.19 Hz. The effects of PAS on VM motor pathway excitability and muscle activity were assessed during pedaling. TMS-induced motor evoked potential (MEP) amplitudes and the percent of VM activity in the flexion phase of active pedaling (%FLEXVM) was examined before and after PAS. Results Inhibitory PAS reduced VM MEP amplitudes in the target limb (p < 0.05) of both groups, while post-PAS paretic VM MEP amplitudes increased for some patients and decreased for others. Group mean paretic limb %FLEXVM was not altered by inhibitory PAS. Conclusions These results indicate PAS can be used to manipulate motor cortical excitability in proximal lower limb representations, however the sign of induced modulation was unpredictable and cyclic muscle activity was not modified. Significance The study has important implications for the development of therapies involving non-invasive brain stimulation to modify abnormal motor behavior following stroke. PMID:21130032

  19. The effects of paired associative stimulation on knee extensor motor excitability of individuals post-stroke: a pilot study.

    PubMed

    Rogers, Lynn M; Brown, David A; Stinear, James W

    2011-06-01

    Paired associative stimulation (PAS) modulates bilateral distal lower limb motor pathways during walking. We assessed the effects of inhibitory PAS applied to the vastus medialis (VM) motor pathways of chronic stroke patients. PAS consisted of 120 electrical stimuli applied to the femoral nerve paired with transcranial magnetic stimulation (TMS) of the lower limb primary motor cortex so that the estimated arrival of the afferent volley occurred 8 ms after delivery of the magnetic stimulus. Stimulus pairs were delivered to the non-paretic VM motor system of 11 chronic stroke patients and the right limb motor system of 11 non-impaired subjects at 0.19 Hz. The effects of PAS on VM motor pathway excitability and muscle activity were assessed during pedaling. TMS-induced motor evoked potential (MEP) amplitudes and the percent of VM activity in the flexion phase of active pedaling (% FLEXVM) was examined before and after PAS. Inhibitory PAS reduced VM MEP amplitudes in the target limb (p<0.05) of both groups, while post-PAS paretic VM MEP amplitudes increased for some patients and decreased for others. Group mean paretic limb % FLEXVM was not altered by inhibitory PAS. These results indicate PAS can be used to manipulate motor cortical excitability in proximal lower limb representations, however the sign of induced modulation was unpredictable and cyclic muscle activity was not modified. The study has important implications for the development of therapies involving non-invasive brain stimulation to modify abnormal motor behavior following stroke. Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  20. How electronic health records can unmask the hidden value of PAs.

    PubMed

    Ogunfiditimi, Folusho; Sherry, Scott P; Foote, Monica; Christie, Sarah L; Shock, Lisa P; Cawley, James; Browne, Aaron

    2017-06-01

    The Fee for Value (FFV) Task Force, a subgroup of the American Academy of PAs' Research and Strategic Initiatives Commission, has examined tools and mechanisms aimed at better clarifying the volume and value of PA work and how that work contributes to improving access to high-quality care. Establishing the value of PAs has been a challenging task for many healthcare providers. Often, PA value has been defined by their clinical productivity, without any clear direction as to what constitutes value versus productivity. The objective of this article is to unmask the value of PAs through the role of electronic health records and highlight PAs' ability to produce services that are value-oriented and quantifiably productive.

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