Sample records for program h10-026 contract

  1. 42 CFR 52h.10 - What matters must be reviewed for solicited contract proposals?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What matters must be reviewed for solicited contract proposals? 52h.10 Section 52h.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... CONTRACT PROJECTS § 52h.10 What matters must be reviewed for solicited contract proposals? (a) Subject to...

  2. 41 CFR 105-70.026 - Form, filing and service of papers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of papers. 105-70.026 Section 105-70.026 Public Contracts and Property Management Federal Property... service of papers. (a) Form. (1) Documents filed with the ALJ shall include an original and two copies. (2) Every pleading and paper filed in the proceeding shall contain a caption setting forth the title of the...

  3. The effect of higher ATP cost of contraction on the metabolic response to graded exercise in patients with chronic obstructive pulmonary disease.

    PubMed

    Layec, Gwenael; Haseler, Luke J; Richardson, Russell S

    2012-03-01

    To better understand the metabolic implications of a higher ATP cost of contraction in chronic obstructive pulmonary disease (COPD), we used (31)P-magnetic resonance spectroscopy ((31)P-MRS) to examine muscle energetics and pH in response to graded exercise. Specifically, in six patients and six well-matched healthy controls, we determined the intracellular threshold for pH (T(pH)) and inorganic phosphate-to-phosphocreatine ratio (T(Pi/PCr)) during progressive dynamic plantar flexion exercise with work rate expressed as both absolute and relative intensity. Patients with COPD displayed a lower peak power output (WRmax) compared with controls (controls 25 ± 4 W, COPD 15 ± 5 W, P = 0.01) while end-exercise pH (controls 6.79 ± 0.15, COPD 6.76 ± 0.21, P = 0.87) and PCr consumption (controls 82 ± 10%, COPD 70 ± 18%, P = 0.26) were similar between groups. Both T(pH) and T(Pi/PCr) occurred at a significantly lower absolute work rate in patients with COPD compared with controls (controls: 14.7 ± 2.4 W for T(pH) and 15.3 ± 2.4 W for T(Pi/PCr); COPD: 9.7 ± 4.5 W for T(pH) and 10.0 ± 4.6 W for T(Pi/PCr), P < 0.05), but these thresholds occurred at the same percentage of WRmax (controls: 63 ± 11% WRmax for T(pH) and 67 ± 18% WRmax for T(Pi/PCr); COPD: 59 ± 9% WRmax for T(pH) and 61 ± 12% WRmax for T(Pi/PCr), P > 0.05). Indexes of mitochondrial function, the PCr recovery time constant (controls 42 ± 7 s, COPD 45 ± 11 s, P = 0.66) and the PCr resynthesis rate (controls 105 ± 21%/min, COPD 91 ± 31%/min, P = 0.43) were similar between groups. In combination, these results reveal that when energy demand is normalized to WRmax, as a consequence of higher ATP cost of contraction, patients with COPD display the same metabolic pattern as healthy subjects, suggesting that skeletal muscle energy production is well preserved in these patients.

  4. 48 CFR 1815.7001 - NASA Ombudsman Program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

  5. 48 CFR 1815.7001 - NASA Ombudsman Program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

  6. 48 CFR 1815.7001 - NASA Ombudsman Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

  7. 48 CFR 1815.7001 - NASA Ombudsman Program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

  8. 48 CFR 1815.7001 - NASA Ombudsman Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

  9. The Effects of Two Different Stretching Programs on Balance Control and Motor Neuron Excitability

    ERIC Educational Resources Information Center

    Kaya, Fatih; Biçer, Bilal; Yüktasir, Bekir; Willems, Mark E. T.; Yildiz, Nebil

    2018-01-01

    We examined the effects of training (4d/wk for 6 wks) with static stretching (SS) or contract-relax proprioceptive neuromuscular facilitation (PNF) on static balance time and motor neuron excitability. Static balance time, H[subscript max]/M[subscript max] ratios and H-reflex recovery curves (HRRC) were measured in 28 healthy subjects (SS: n = 10,…

  10. Effect of intermittent eccentric contractions on symptoms of muscle microinjury.

    PubMed

    Teague, B N; Schwane, J A

    1995-10-01

    The purpose was to determine whether varying the duration of rest between contractions affects selected symptoms of eccentric contraction-induced skeletal muscle microinjury. Thirty-three women were assigned to three groups (N = 11). Each performed one bout of exercise with each arm involving 10 eccentric contractions of the elbow flexor muscles, lowering a load equaling 60% of maximal static force. One arm exercised continuously; the other exercised with rest periods of 15 s, 5 min, or 10 min between contractions, depending on the group. Preexercise and 0, 24, and 48 h postexercise, symptoms of microinjury in the elbow flexor muscles were assessed: soreness and changes in strength, resting elbow angle ("musculotendinous stiffness"), and arm girth ("swelling"). For all groups combined, 10 continuous contractions caused changes (P < 0.05) in all variables at every measurement time. For example, soreness ratings (0-10 scale) were 4.3 +/- 2.0 (24 h) and 4.3 +/- 2.1 (48 h) and strength was reduced 18% 0 h postexercise. Responses were similar with 15 s of rest between contractions. Although they were moderated, symptoms occurred even with 5 and 10 min of rest. With 10 min between contractions, soreness occurred (e.g., 2.4 +/- 1.5 [24 h]) and strength was 17% reduced 0 h postexercise. Results are most consistent with a mechanical cause of eccentric contraction-induced muscle microinjury, rather than a metabolic or other factor with a short recovery time, although involvement of the latter cannot be ruled out.

  11. 42 CFR 52h.9 - What matters must be reviewed for unsolicited contract proposals?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What matters must be reviewed for unsolicited contract proposals? 52h.9 Section 52h.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN... PROJECTS § 52h.9 What matters must be reviewed for unsolicited contract proposals? (a) Except as otherwise...

  12. The effect of compound 48/80 on contractions induced by toluene diisocyanate in isolated guinea-pig bronchus.

    PubMed

    Mapp, C E; Boniotti, A; Papi, A; Chitano, P; Coser, E; Di Stefano, A; Saetta, M; Ciaccia, A; Fabbri, L M

    1993-06-01

    We have investigated the ability of compound 48/80 and of histamine H1 and H2 receptor antagonists to inhibit toluene diisocyanate-induced contractions in isolated guinea-pig bronchi. Compound 48/80 (100 micrograms/ml) significantly inhibited toluene diisocyanate-induced contractions. By contrast, the two histamine H1 and H2 receptor antagonists, chlorpheniramine (10 microM) and cimetidine, (10 microM) did not affect toluene diisocyanate-induced contractions, but significantly inhibited contractions induced by exogenously applied histamine (100 microM) and by 48/80. We investigated which mechanisms 48/80 used to inhibit toluene diisocyanate-induced contractions, paying particular attention to the possible involvement of capsaicin-sensitive primary afferents. In vitro capsaicin desensitization (10 microM for 30 min followed by washing) significantly reduced compound 48/80-induced contractions. A capsaicin-resistant component of contraction was also evident. Ruthenium red (3 microM), an inorganic dye which acts as a selective functional antagonist of capsaicin, did not affect 48/80-induced contraction. MEN 10,207 (Tyr5,D-Trp6,8,9,Arg10)-neurokinin A (4-10) (3 microM) a selective antagonist of NK2-tachykinin receptors significantly reduced 48/80-induced contractions. These results show that compound 48/80 inhibits toluene diisocyanate-induced contractions in isolated guinea-pig bronchi. It is likely that two mechanisms are involved in the inhibition: (1) the release of mediators other than histamine by mast cells, (2) an effect of 48/80 on sensory nerves.

  13. 48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

  14. 48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

  15. 48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

  16. 48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

  17. 48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

  18. Detection of Neutral Phosphorus in the Near-ultraviolet Spectra of Late-type Stars

    NASA Astrophysics Data System (ADS)

    Roederer, Ian U.; Jacobson, Heather R.; Thanathibodee, Thanawuth; Frebel, Anna; Toller, Elizabeth

    2014-12-01

    We report the detection of several absorption lines of neutral phosphorus (P, Z = 15) in archival near-ultraviolet spectra obtained with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. We derive phosphorus abundances or interesting upper limits in 14 late-type stars with metallicities spanning -3.8 < [Fe/H] <-0.1. Previously, phosphorus had only been studied in Galactic stars with -1.0 < [Fe/H] <+0.3. Iron lines reveal abundance offsets between the optical and ultraviolet regions, and we discuss and apply a correction factor to account for this offset. In stars with [Fe/H] >-1.0, the [P/Fe] ratio decreases toward the solar value with increasing metallicity, in agreement with previous observational studies. In stars with [Fe/H] <-1.0, lang[P/Fe]rang = +0.04 ± 0.10, which overlaps with the [P/Fe] ratios found in several high-redshift damped Lyman-α systems. This behavior hints at a primary origin in massive stars. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. This work is supported through program AR-13246 and is based on observations associated with programs GO-7348, GO-7433, GO-8197, GO-9048, GO-9049, GO-9455, GO-9804, GO-12268, GO-12554, and GO-12976. Portions of this work are based on data obtained from the European Southern Observatory (ESO) Science Archive Facility. These data are associated with Programs 065.L-0507(A), 067.D-0439(A), 072.B-0179(A), 074.C-0364(A), 076.B-0055(A), and 266.D-5655(A). Portions of this research have also made use of the Keck Observatory Archive (KOA), which is operated by the W.M. Keck Observatory and the NASA Exoplanet Science Institute (NExScI), under contract with the National Aeronautics and Space Administration. These data are associated with Programs H2aH (P.I: Boesgaard), H5aH (P.I: Stephens), and H47aH (P.I: Boesgaard). Other portions of this work are based on data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile, and the McDonald Observatory of The University of Texas at Austin.

  19. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or performance...

  20. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or performance...

  1. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or performance...

  2. Probiotic (VSL#3) for Gulf War Illness

    DTIC Science & Technology

    2012-10-01

    W81XWH-10-1-0593 TITLE: Probiotic (VSL#3) for Gulf War Illness. PRINCIPAL INVESTIGATOR: Ashok Tuteja, M.D. M.P.H...SUBTITLE 5a. CONTRACT NUMBER Probiotic (VSL#3) for Gulf War Illness 5b. GRANT NUMBER W81XWH-10-1-0593 5c. PROGRAM ELEMENT NUMBER...unable to get IND (Investigational New Drug) number for the probiotic , Bifidobacterium infantis 35624 (Align®). We requested the Department of Defense

  3. 48 CFR 970.2305 - Workplace substance abuse programs-management and operating contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Workplace substance abuse programs-management and operating contracts. 970.2305 Section 970.2305 Federal Acquisition Regulations... Work Place 970.2305 Workplace substance abuse programs—management and operating contracts. ...

  4. 48 CFR 970.2305 - Workplace substance abuse programs-management and operating contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Workplace substance abuse programs-management and operating contracts. 970.2305 Section 970.2305 Federal Acquisition Regulations... Work Place 970.2305 Workplace substance abuse programs—management and operating contracts. ...

  5. 48 CFR 970.2305 - Workplace substance abuse programs-management and operating contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Workplace substance abuse programs-management and operating contracts. 970.2305 Section 970.2305 Federal Acquisition Regulations... Work Place 970.2305 Workplace substance abuse programs—management and operating contracts. ...

  6. 48 CFR 970.2305 - Workplace substance abuse programs-management and operating contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Workplace substance abuse programs-management and operating contracts. 970.2305 Section 970.2305 Federal Acquisition Regulations... Work Place 970.2305 Workplace substance abuse programs—management and operating contracts. ...

  7. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Program accessibility: Existing facilities. 51-10.150 Section 51-10.150 Public Contracts and Property Management Other Provisions... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  8. Electrohysterographic characterization of the uterine myoelectrical response to labor induction drugs.

    PubMed

    Benalcazar-Parra, Carlos; Ye-Lin, Yiyao; Garcia-Casado, Javier; Monfort-Orti, Rogelio; Alberola-Rubio, Jose; Perales, Alfredo; Prats-Boluda, Gema

    2018-06-01

    Labor induction is a common practice to promote uterine contractions and labor onset. Uterine electrohysterogram (EHG) has proved its suitability for characterizing the uterus electrophysiological condition in women with spontaneous labor. The aim of this study was to characterize and compare uterine myoelectrical activity during the first 4 h in response to labor induction drugs, Misoprostol (G1) and Dinoprostone (G2), by analyzing the differences between women who achieved active phase of labor and those who did not (successful and failed inductions). A set of temporal, spectral and complexity parameters were computed from the EHG-bursts. As for successful inductions, statistical significant and sustained increases with respect to basal period were obtained for EHG amplitude, mean frequency, uterine activity index (UAI) and Teager, after 60' for the G1 group; duration, amplitude, number of contractions and UAI for the G2 group, after 120'. Moreover, Teager showed statistical significant and sustained differences between successful and failed inductions (1.43 ± 1.45 µV 2. Hz 2. 10 5  vs. 0.40 ± 0.26 µV 2. Hz 2. 10 5 after 240') for the G1 group, but not in the G2 group, probably due to the slower pharmacokinetics of this drug. These results revealed that EHG could be useful for successful induction prediction in the early stages of induction, especially when using Misoprostol. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 926.7104 Section 926.7104 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 926.7104 Contract clause....

  10. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract clause. 926.7104 Section 926.7104 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 926.7104 Contract clause....

  11. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 926.7104 Section 926.7104 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 926.7104 Contract clause....

  12. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 926.7104 Section 926.7104 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 926.7104 Contract clause....

  13. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clause. 926.7104 Section 926.7104 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 926.7104 Contract clause....

  14. 48 CFR 2146.270 - FEGLI Program quality assurance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 2146.270 FEGLI Program quality assurance requirements. (a) The... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false FEGLI Program quality...

  15. 48 CFR 2146.270 - FEGLI Program quality assurance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 2146.270 FEGLI Program quality assurance requirements. (a) The... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false FEGLI Program quality...

  16. 48 CFR 2146.270 - FEGLI Program quality assurance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 2146.270 FEGLI Program quality assurance requirements. (a) The... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false FEGLI Program quality...

  17. 48 CFR 2146.270 - FEGLI Program quality assurance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 2146.270 FEGLI Program quality assurance requirements. (a) The... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false FEGLI Program quality...

  18. 48 CFR 2146.270 - FEGLI Program quality assurance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 2146.270 FEGLI Program quality assurance requirements. (a) The... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEGLI Program quality...

  19. 48 CFR 822.406-11 - Contract terminations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts Involving Construction 822.406-11 Contract terminations. (a) Contracting officers must submit any proposed... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract terminations. 822...

  20. 42 CFR 421.212 - Railroad Retirement Board contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Railroad Retirement Board contracts. 421.212... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE CONTRACTING Carriers § 421.212 Railroad Retirement Board contracts. In accordance with this subpart C, the Railroad Retirement Board contracts with DMEPOS regional...

  1. 10 CFR 850 Implementation of Requirements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, S

    2012-01-05

    10 CFR 850 defines a contractor as any entity, including affiliated entities, such as a parent corporation, under contract with DOE, including a subcontractor at any tier, with responsibility for performing work at a DOE site in furtherance of a DOE mission. The Chronic Beryllium Disease Prevention Program (CBDPP) applies to beryllium-related activities that are performed at the Lawrence Livermore National Laboratory (LLNL). The CBDPP or Beryllium Safety Program is integrated into the LLNL Worker Safety and Health Program and, thus, implementation documents and responsibilities are integrated in various documents and organizational structures. Program development and management of the CBDPPmore » is delegated to the Environment, Safety and Health (ES&H) Directorate, Worker Safety and Health Functional Area. As per 10 CFR 850, Lawrence Livermore National Security, LLC (LLNS) periodically submits a CBDPP to the National Nuclear Security Administration/Livermore Site Office (NNSA/LSO). The requirements of this plan are communicated to LLNS workers through ES&H Manual Document 14.4, 'Working Safely with Beryllium.' 10 CFR 850 is implemented by the LLNL CBDPP, which integrates the safety and health standards required by the regulation, components of the LLNL Integrated Safety Management System (ISMS), and incorporates other components of the LLNL ES&H Program. As described in the regulation, and to fully comply with the regulation, specific portions of existing programs and additional requirements are identified in the CBDPP. The CBDPP is implemented by documents that interface with the workers, principally through ES&H Manual Document 14.4. This document contains information on how the management practices prescribed by the LLNL ISMS are implemented, how beryllium hazards that are associated with LLNL work activities are controlled, and who is responsible for implementing the controls. Adherence to the requirements and processes described in the ES&H Manual ensures that ES&H practices across LLNL are developed in a consistent manner. Other implementing documents, such as the ES&H Manual, are integral in effectively implementing 10 CFR 850.« less

  2. 48 CFR 1519.203 - Mentor-protege.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mentor-protege. 1519.203... PROGRAMS SMALL BUSINESS PROGRAMS Policies 1519.203 Mentor-protege. (a) The Contracting officer shall insert the clause at 1552.219-70, Mentor-Protege Program, in all contracts under which the Contractor has...

  3. 48 CFR 225.872-5 - Contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Policy and International Contracting), ((703) 697-9351, DSN 227-9351). (b) Follow the contract... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract administration... SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements...

  4. 48 CFR 225.872-5 - Contract administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Policy and International Contracting), ((703) 697-9351, DSN 227-9351). (b) Follow the contract... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract administration... SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements...

  5. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements. ...

  6. 48 CFR 1430.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract requirements. 1430.201 Section 1430.201 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1430.201 Contract...

  7. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements. ...

  8. 48 CFR 430.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract requirements. 430.201 Section 430.201 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.201 Contract...

  9. 48 CFR 30.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract requirements. 30.201 Section 30.201 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201 Contract...

  10. 48 CFR 1330.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract requirements. 1330.201 Section 1330.201 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1330.201 Contract...

  11. 45 CFR 800.401 - Contract performance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Contract performance. 800.401 Section 800.401...-STATE PLAN PROGRAM Compliance § 800.401 Contract performance. (a) General. An MSPP issuer must perform... MSPP contract; (7) Applying performance standards for assuring contract quality as outlined at § 800...

  12. 45 CFR 800.401 - Contract performance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Contract performance. 800.401 Section 800.401...-STATE PLAN PROGRAM Compliance § 800.401 Contract performance. (a) General. An MSPP issuer must perform... MSPP contract; (7) Applying performance standards for assuring contract quality as outlined at § 800...

  13. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  14. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  15. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  16. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  17. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  18. Probiotic (VSL 3) for Gulf War Illness

    DTIC Science & Technology

    2016-10-01

    Award Number: W81XWH-10-1-0593 TITLE: Probiotic (VSL#3) for Gulf War Illness. PRINCIPAL INVESTIGATOR: Ashok Tuteja, M.D. M.P.H. CONTRACTING...NUMBER Probiotic (VSL#3) for Gulf War Illness. 5b. GRANT NUMBER W81XWH-10-1-0593 5c. PROGRAM ELEMENT NUMBER 6 . AUTHOR(S) 5d. PROJECT NUMBER Ashok...objective of the study is to determine whether probiotic VisbiomeTMwill improve 1) Intestinal symptoms of Irritable Bowel Syndrome and 2) Non

  19. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  20. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  1. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  2. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  3. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  4. 48 CFR 22.610 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act 22.610... Contracts Act, in solicitations and contracts covered by the Act (see 22.603, 22.604, and 22.605). [61 FR... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 22.610...

  5. Influence of pelvic floor muscle contraction on the profile of vaginal closure pressure in continent and stress urinary incontinent women.

    PubMed

    Shishido, Keiichi; Peng, Qiyu; Jones, Ruth; Omata, Sadao; Constantinou, Christos E

    2008-05-01

    We characterized the vaginal pressure profile as a representation of closure forces along the length and circumference of the vaginal wall. Vaginal pressure profile data were used to test the hypothesis that the strength of pelvic floor muscle contractions differs significantly between continent women and women with stress urinary incontinence. Vaginal pressure profile recordings were made in 23 continent subjects and in 10 patients with stress urinary incontinence. The recordings characterized closure forces along the entire length of the vagina and identified differences among the anterior, posterior, left and right sides of the vaginal wall. Using a novel, directionally sensitive vaginal probe we made vaginal pressure profile measurements with the women at rest and during pelvic floor muscle contraction while supine. The nature of the vaginal pressure profile was characterized in terms of force distribution in the anterior and posterior vaginal walls, which was significantly greater than that on the left and right sides. The continent group had significant greater maximum pressure than the stress urinary incontinence group on the posterior side at rest (mean +/- SE 3.4 +/- 0.3 vs 2.01 +/- 0.36 N/cm(2)) and during pelvic floor muscle contraction (4.18 +/- 0.26 vs 2.25 +/- 0.41 N/cm(2)). The activity pressure difference between the posterior and anterior vaginal walls in the continent group was significantly increased when the pelvic floor muscles contracted vs that at rest (3.29 +/- 0.21 vs 2.45 +/- 0.26 N/cm(2)). However, the change observed in the stress urinary incontinence group was not significant (1.85 +/- 0.38 vs 1.35 +/- 0.27 N/cm(2)). The results demonstrate that the voluntary pelvic floor muscles impose significant closure forces along the vaginal wall of continent women but not in women with stress urinary incontinence. The implication of these findings is that extrinsic urethral closure pressure is insufficiently augmented by pelvic floor muscle contraction in women with stress urinary incontinence.

  6. 48 CFR 19.804-2 - Agency offering.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Agency offering. 19.804-2... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19... following information applicable to each prospective contract: (1) A description of the work to be performed...

  7. 48 CFR 570.603 - GSAR contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false GSAR contract clauses. 570.603 Section 570.603 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Solicitation Provisions and Contract...

  8. 48 CFR 1819.7302 - NASA contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA contract clauses. 1819.7302 Section 1819.7302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Business Technology Transfer (STTR) Programs 1819.7302 NASA contract clauses. (a) Contracting officers...

  9. 48 CFR 1819.7302 - NASA contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA contract clauses. 1819.7302 Section 1819.7302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Business Technology Transfer (STTR) Programs 1819.7302 NASA contract clauses. (a) Contracting officers...

  10. 48 CFR 1819.7302 - NASA contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA contract clauses. 1819.7302 Section 1819.7302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Business Technology Transfer (STTR) Programs 1819.7302 NASA contract clauses. (a) Contracting officers...

  11. 48 CFR 1819.7302 - NASA contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA contract clauses. 1819.7302 Section 1819.7302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Business Technology Transfer (STTR) Programs 1819.7302 NASA contract clauses. (a) Contracting officers...

  12. 48 CFR 1819.7302 - NASA contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA contract clauses. 1819.7302 Section 1819.7302 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Business Technology Transfer (STTR) Programs 1819.7302 NASA contract clauses. (a) Contracting officers...

  13. 48 CFR 322.810 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Solicitation provisions and contract clauses. 322.810 Section 322.810 Federal Acquisition Regulations System HEALTH AND HUMAN... Opportunity 322.810 Solicitation provisions and contract clauses. (h) The Contracting Officer shall insert the...

  14. 48 CFR 322.810 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 322.810 Section 322.810 Federal Acquisition Regulations System HEALTH AND HUMAN... Opportunity 322.810 Solicitation provisions and contract clauses. (h) The Contracting Officer shall insert the...

  15. 76 FR 11411 - Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... This rule was not subject to Office of Management and Budget review under Executive Order 12866, dated... Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C. chapter 35). List of... notification to the Office of Management and Budget at least 14 days before contract award. 3. Section 217.171...

  16. 42 CFR 417.408 - Contract application process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Contract application process. 417.408 Section 417... (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Qualifying Conditions for Medicare Contracts § 417.408 Contract application process. (a...

  17. 48 CFR 970.5223-4 - Workplace Substance Abuse Programs at DOE Sites.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Workplace Substance Abuse... and Contract Clauses for Management and Operating Contracts 970.5223-4 Workplace Substance Abuse... 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites, incorporated herein by reference...

  18. 48 CFR 970.5223-4 - Workplace Substance Abuse Programs at DOE Sites.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Workplace Substance Abuse... and Contract Clauses for Management and Operating Contracts 970.5223-4 Workplace Substance Abuse... 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites, incorporated herein by reference...

  19. 48 CFR 970.5223-4 - Workplace Substance Abuse Programs at DOE Sites.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Workplace Substance Abuse... and Contract Clauses for Management and Operating Contracts 970.5223-4 Workplace Substance Abuse... 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites, incorporated herein by reference...

  20. 48 CFR 970.5223-4 - Workplace Substance Abuse Programs at DOE Sites.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Workplace Substance Abuse... and Contract Clauses for Management and Operating Contracts 970.5223-4 Workplace Substance Abuse... 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites, incorporated herein by reference...

  1. 48 CFR 970.5223-4 - Workplace Substance Abuse Programs at DOE Sites.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Workplace Substance Abuse... and Contract Clauses for Management and Operating Contracts 970.5223-4 Workplace Substance Abuse... 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites, incorporated herein by reference...

  2. 48 CFR 2419.808 - Contract negotiation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract negotiation. 2419.808 Section 2419.808 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN...) Program 2419.808 Contract negotiation. ...

  3. 48 CFR 2419.808 - Contract negotiation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract negotiation. 2419.808 Section 2419.808 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN...) Program 2419.808 Contract negotiation. ...

  4. 48 CFR 3019.708 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 3019.708 Section 3019.708 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting...

  5. 48 CFR 26.201 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Disaster or Emergency Assistance Activities 26.201 Definitions. Emergency response contract means a contract with private entities that supports assistance activities in a... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Definitions. 26.201...

  6. 48 CFR 219.808 - Contract negotiations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract negotiations. 219.808 Section 219.808 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Administration (The 8(a) Program) 219.808 Contract negotiations. ...

  7. 48 CFR 219.808 - Contract negotiations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract negotiations. 219.808 Section 219.808 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Administration (The 8(a) Program) 219.808 Contract negotiations. ...

  8. 48 CFR 219.808 - Contract negotiations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract negotiations. 219.808 Section 219.808 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Administration (The 8(a) Program) 219.808 Contract negotiations. ...

  9. 48 CFR 219.808 - Contract negotiations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contract negotiations. 219.808 Section 219.808 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Administration (The 8(a) Program) 219.808 Contract negotiations. ...

  10. 48 CFR 219.808 - Contract negotiations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contract negotiations. 219.808 Section 219.808 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Administration (The 8(a) Program) 219.808 Contract negotiations. ...

  11. 48 CFR 2132.772 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 2132.772 Section 2132.772 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES... Contract Funding 2132.772 Contract clause. The clause at 2152.232-71 shall be inserted in all FEGLI Program...

  12. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  13. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  14. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  15. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  16. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  17. In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.

    PubMed

    Lecci, A; Giuliani, S; Tramontana, M; Meini, S; De Giorgio, R; Maggi, C A

    1996-05-01

    In urethane-anaesthetized rats, moderate colonic distention (0.5 ml) induced reflex rhythmic contractions (5 mm Hg amplitude and 1.1 cycles/min frequency). Senktide (1-10 nmol/kg, i.v.), a tachykinin NK3 receptor selective agonist, transiently suppressed distension-induced contractions. SR 142,801 (1-10 mumol/kg i.v.), a non-peptide tachykinin NK3 receptor antagonist, had no effect on distension-induced contractions but prevented the inhibitory effect of senktide. Infusion of N-omega-nitro-1-arginine methyl esther hydrochloride (L-NAME, 20 mumol/ml/h, i.v) increased the amplitude of colonic contractions and decreased the inhibitory effect of senktide. Hexamethonium (15 mumol/ml/h, i.v.) or atropine (1 mumol/ml/h, i.v.) inhibited the distension-induced contractions. In hexamethonium- or atropine-treated rats, senktide (10 nmol/kg) transiently and selectively enhanced the amplitude of contractions. Also SR 142,801 (10 mumol/kg), but not its inactive enantiomer SR 142,806, increased both amplitude and frequency of contractions. During continuous infusion of L-NAME and hexamethonium or atropine both frequency and amplitude of distension-induced colonic contractions were higher than when in hexamethonium or atropine only. Senktide (10 nmol/kg) had no effect and SR 142,801 (10 mumol/kg) produced a slight enhancement of colonic contractions. Infusion of sodium nitroprusside (3 mumol/ml/h, i.v.) decreased amplitude and frequency of distension-induced contractions. SR 142,801 had no effect in the presence of the nitric oxide (NO) donor. We conclude that tachykinins acting through NK3 receptors exert at least four different actions on colonic motility activated by distension: 1) a hexamethonium-resistant, NO-dependent, suppressant effect on contractions; 2) a hexamethonium-sensitive, NO-independent inhibitory effect on the amplitude of contractions; 3) a hexamethonium-resistant, NO-independent inhibitory effect on the amplitude of contractions and 4) a hexamethonium resistant and L-NAME-sensitive excitatory effect on amplitude of contractions. The prevalent inhibitory effect evoked in normal conditions along with the excitatory activity induced by SR 142,801 on hexamethonium-resistant colonic motility indicates that tachykinins, acting through neuronal NK3 receptors, activate NO-dependent and NO-independent inhibitory neurotransmission in the rat colon.

  18. 48 CFR 19.602-4 - Awarding the contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Awarding the contract. 19.602-4 Section 19.602-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility...

  19. 48 CFR 19.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Pricing the 8(a) contract...) Program) 19.806 Pricing the 8(a) contract. (a) The contracting officer shall price the 8(a) contract in accordance with subpart 15.4. If required by subpart 15.4, the SBA shall obtain certified cost or pricing...

  20. 48 CFR 1819.708-70 - NASA solicitation provision and contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA solicitation provision and contract clause. 1819.708-70 Section 1819.708-70 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708-70 NASA solicitation provision and contract clause. (a) The contracting officer...

  1. 48 CFR 22.1003-5 - Some examples of contracts covered.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Some examples of contracts... SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1003-5 Some examples of contracts covered. The following examples, while not definitive or...

  2. 43 CFR 422.9 - Reclamation law enforcement contracts and cooperative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Reclamation law enforcement contracts and... PROJECTS Program Requirements § 422.9 Reclamation law enforcement contracts and cooperative agreements. (a... Federal laws. (b) Each contract and cooperative agreement authorizing the exercise of Reclamation law...

  3. 48 CFR 819.7004 - Contracting Order of Priority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting Order of Priority. 819.7004 Section 819.7004 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business...

  4. 48 CFR 819.7004 - Contracting Order of Priority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contracting Order of Priority. 819.7004 Section 819.7004 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business...

  5. The effectiveness of fish oil supplementation in asthmatic rats is limited by an inefficient action on ASM function.

    PubMed

    Miranda, D T S Z; Zanatta, A L; Dias, B C L; Fogaça, R T H; Maurer, J B B; Donatti, L; Calder, P C; Nishiyama, A

    2013-09-01

    Episodes of acute exacerbation are the major clinical feature of asthma and therefore represent an important focus for developing novel therapies for this disease. There are many reports that the n-3 fatty acids found in fish oil exert anti-inflammatory effects, but there are few studies of the action of fish oil on airway smooth muscle (ASM) function. In the present investigation, we evaluated the effect of fish oil supplementation on smooth muscle force of contraction in ovalbumin-induced asthmatic Wistar rats, and its consequences on static lung compliance, mucus production, leukocyte chemotaxis and production of proinflammatory cytokines. Fish oil supplementation suppressed the infiltration of inflammatory cells into the lung in asthmatic animals (2.04 ± 0.19 × 10(6) cells vs. 3.33 ± 0.43 × 10(6) cells in the control asthmatic group; P < 0.05). Static lung compliance increased with fish oil supplementation in asthmatic rats (0.640 ± 0.053 mL/cm H2O vs. 0.399 ± 0.043 mL/cm H2O; P < 0.05). However, fish oil did not prevent asthma-associated lung eosinophilia and did not affect the concentrations of tumor necrosis factor-α and interleukin-1β in lung tissue or the proportion of the airways obliterated with mucus. Fish oil had no effect on the force of contraction in asthmatic rats in response to acetylcholine (3.026 ± 0.274 mN vs. 2.813 ± 0.364 mN in the control asthmatic group). In conclusion, although fish oil exerts some benefits in this model of asthma, its effectiveness appears to be limited by an inefficient action on airway smooth muscle function.

  6. 48 CFR 917.7301 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Policy. 917.7301 Section 917.7301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7301 Policy. ...

  7. 48 CFR 2144.102 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2144.102 Section... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES General 2144.102 Policy. For all FEGLI Program contracts, the Contracting Officer's advance...

  8. 48 CFR 2144.102 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2144.102 Section... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES General 2144.102 Policy. For all FEGLI Program contracts, the Contracting Officer's advance...

  9. 48 CFR 2144.102 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2144.102 Section... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES General 2144.102 Policy. For all FEGLI Program contracts, the Contracting Officer's advance...

  10. 41 CFR 51-10.160 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Communications. 51-10.160 Section 51-10.160 Public Contracts and Property Management Other Provisions Relating to Public Contracts... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  11. The abundance of functional genes, cbbL, nifH, amoA and apsA, and bacterial community structure of intertidal soil from Arabian Sea.

    PubMed

    Keshri, Jitendra; Yousuf, Basit; Mishra, Avinash; Jha, Bhavanath

    2015-06-01

    The Gulf of Cambay is a trumpet-shaped inlet of the Arabian Sea, located along the west coast of India and confronts a high tidal range with strong water currents. The region belongs to a semi-arid zone and saline alkaline intertidal soils are considered biologically extreme. The selected four soil types (S1-S4) were affected by salinity, alkalinity and sodicity. Soil salinity ranged from 20 to 126 dS/m, soil pH 8.6-10.0 with high sodium adsorption ratio (SAR) and exchangeable sodium percentage (ESP). Abundance of the key functional genes like cbbL, nifH, amoA and apsA involved in biogeochemical cycling were targeted using qPCR, which varied from (2.36 ± 0.03) × 10(4) to (2.87 ± 0.26) × 10(8), (1.18 ± 0.28) × 10(6) to (1.01 ± 0.26) × 10(9), (1.41 ± 0.21) × 10(6) to (1.29 ± 0.05) × 10(8) and (8.47 ± 0.23) × 10(4) to (1.73 ± 0.01) × 10(6) per gram dry weight, respectively. The microbial community structure revealed that soils S1 and S3 were dominated by phylum Firmicutes whereas S4 and S2 showed an abundance of Proteobacterial clones. These soils also represented Bacteroidetes, Chloroflexi, Actinobacteria, Planctomycetes and Acidobacteria clones. Molecular phylogeny showed a significant variation in the bacterial community distribution among the intertidal soil types. A high number of novel taxonomic units were observed which makes the intertidal zone a unique reservoir of unidentified bacterial taxa that may be explored further. Copyright © 2015 Elsevier GmbH. All rights reserved.

  12. 41 CFR 102-193.10 - What are the goals of the Federal Records Management Program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... maintenance of management controls that prevent the creation of unnecessary records and promote effective and... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are the goals of the Federal Records Management Program? 102-193.10 Section 102-193.10 Public Contracts and Property...

  13. 48 CFR 719.273-11 - Solicitation provision and contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Solicitation provision and contract clause. 719.273-11 Section 719.273-11 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The U.S. Agency for International...

  14. 48 CFR 719.273-11 - Solicitation provision and contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Solicitation provision and contract clause. 719.273-11 Section 719.273-11 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The U.S. Agency for International...

  15. Reforming the Joint Military Establishment

    DTIC Science & Technology

    1985-06-01

    FOR PUBLIC RELEASE DISTRIBUTION UNLIMITED D UNCLASSIFIED StCURITV CLASJiriCATIOM OP THIS PAOK (*h*> Dmf Enltfd) REPORT DOCUMENTATION PAGE 1...COMPLETING FORM i Rt t lRNT’S CATALOG NUMBER 5. TYPE OF HEBORT 4 PCRIOC COVCRCO Final S. PERFORMING ORO. REPORT NUMICR B. CONTRACT OR GRANT...NUMBERft; 10. PROGRAM ELCMENT. PROJECT, TASK AREA ft WORK UNIT NUMBERS U. REPORT OAT1 June 1985 𔃽. NUMBER OF PAGES 78 IS. SECURITY CLASS

  16. 42 CFR 417.427 - Extending MA and Part D program disclosure requirements to section 1876 cost contract plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Extending MA and Part D program disclosure..., and Disenrollment under Medicare Contract § 417.427 Extending MA and Part D program disclosure... chapter must be read as references to this part, and references to MA organizations and Part D sponsors as...

  17. 42 CFR 417.427 - Extending MA and Part D program disclosure requirements to section 1876 cost contract plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Extending MA and Part D program disclosure..., and Disenrollment under Medicare Contract § 417.427 Extending MA and Part D program disclosure... chapter must be read as references to this part, and references to MA organizations and Part D sponsors as...

  18. 42 CFR 417.427 - Extending MA and Part D program disclosure requirements to section 1876 cost contract plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Extending MA and Part D program disclosure..., and Disenrollment under Medicare Contract § 417.427 Extending MA and Part D program disclosure... chapter must be read as references to this part, and references to MA organizations and Part D sponsors as...

  19. 48 CFR 370.304 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract clauses. 370.304 Section 370.304 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES HHS SUPPLEMENTATIONS SPECIAL PROGRAMS AFFECTING ACQUISITION Acquisitions Involving Human Subjects 370.304 Contract clauses. (a...

  20. Regulation of the substance P-induced contraction via the release of acetylcholine and gamma-aminobutyric acid in the guinea-pig urinary bladder.

    PubMed Central

    Shirakawa, J.; Nakanishi, T.; Taniyama, K.; Kamidono, S.; Tanaka, C.

    1989-01-01

    1. The action of substance P (SP) on the release of gamma-aminobutyric acid (GABA) and acetylcholine (ACh) and on contraction were studied in strips of the guinea-pig urinary bladder. Substance P induced a dose-dependent contraction of strips of guinea-pig urinary bladder (EC50 = 1.2 x 10(-9) M). This contraction was not altered by tetrodotoxin, but with a dose of 10(-9) M and less, there was a complete inhibition by 10(-6) M) atropine. Contractions initiated by 3 x 10(-9) M) SP or more were partly inhibited by atropine. The EC50 value of substance P in the presence of atropine was 7.0 x 10(-9) M. 2. Substance P induced a Ca2+-dependent and tetrodotoxin-resistant release of [3H]-acetylcholine (ACh) from strips of urinary bladder preloaded with [3H]-choline (EC50 = 4.9 x 10(-10) M), and this release was antagonized by [D-Pro2,D-Trp7,9] substance P. 3. Bicuculline increased the substance P-induced contraction and the release of [3H]-ACh from the strips. 4. Substance P induced a Ca2+-dependent and tetrodotoxin-sensitive release of [3H]-gamma-aminobutyric acid (GABA) from strips preloaded with [3H]-GABA (EC50 = 2.6 x 10(-9) M), and this release was antagonized by [D-Pro2,D-Trp7,9] substance P. 5. Therefore, substance P appears to exert excitatory effects on the contractility of urinary bladder predominantly by stimulating its own receptor located on the cholinergic nerve terminals. GABA released by substance P inhibits stimulation of the cholinergic neurone. However, the direct action of substance P on the cholinergic neurone is more potent that the indirect action via GABA release. PMID:2479440

  1. 42 CFR 460.70 - Contracted services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Contracted services. 460.70 Section 460.70 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE...

  2. 42 CFR 460.70 - Contracted services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Contracted services. 460.70 Section 460.70 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE...

  3. 42 CFR 422.220 - Exclusion of services furnished under a private contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Exclusion of services furnished under a private contract. 422.220 Section 422.220 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Relationships With...

  4. 48 CFR 317.207 - Exercise of options.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Exercise of options. 317... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.207 Exercise of options. (h) Before exercising an option for a subsequent performance period/additional quantity under a multiple-year contract...

  5. 48 CFR 317.207 - Exercise of options.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Exercise of options. 317... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.207 Exercise of options. (h) Before..., and the Section 508 Official or designee, prior to exercise of an option. The Contracting Officer...

  6. 48 CFR 317.207 - Exercise of options.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Exercise of options. 317... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.207 Exercise of options. (h) Before..., and the Section 508 Official or designee, prior to exercise of an option. The Contracting Officer...

  7. 48 CFR 317.207 - Exercise of options.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Exercise of options. 317... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.207 Exercise of options. (h) Before..., and the Section 508 Official or designee, prior to exercise of an option. The Contracting Officer...

  8. 48 CFR 317.207 - Exercise of options.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Exercise of options. 317... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.207 Exercise of options. (h) Before..., and the Section 508 Official or designee, prior to exercise of an option. The Contracting Officer...

  9. 46 CFR 160.026-4 - Water.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Water. 160.026-4 Section 160.026-4 Shipping COAST GUARD... APPROVAL LIFESAVING EQUIPMENT Water, Emergency Drinking (In Hermetically Sealed Containers), for Merchant Vessels § 160.026-4 Water. (a) Only water meeting the U.S. Public Health Service “Drinking Water Standards...

  10. 46 CFR 160.026-4 - Water.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Water. 160.026-4 Section 160.026-4 Shipping COAST GUARD... APPROVAL LIFESAVING EQUIPMENT Water, Emergency Drinking (In Hermetically Sealed Containers), for Merchant Vessels § 160.026-4 Water. (a) Only water meeting the U.S. Public Health Service “Drinking Water Standards...

  11. 46 CFR 160.026-4 - Water.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Water. 160.026-4 Section 160.026-4 Shipping COAST GUARD... APPROVAL LIFESAVING EQUIPMENT Water, Emergency Drinking (In Hermetically Sealed Containers), for Merchant Vessels § 160.026-4 Water. (a) Only water meeting the U.S. Public Health Service “Drinking Water Standards...

  12. 46 CFR 160.026-4 - Water.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Water. 160.026-4 Section 160.026-4 Shipping COAST GUARD... APPROVAL LIFESAVING EQUIPMENT Water, Emergency Drinking (In Hermetically Sealed Containers), for Merchant Vessels § 160.026-4 Water. (a) Only water meeting the U.S. Public Health Service “Drinking Water Standards...

  13. 46 CFR 160.026-4 - Water.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Water. 160.026-4 Section 160.026-4 Shipping COAST GUARD... APPROVAL LIFESAVING EQUIPMENT Water, Emergency Drinking (In Hermetically Sealed Containers), for Merchant Vessels § 160.026-4 Water. (a) Only water meeting the U.S. Public Health Service “Drinking Water Standards...

  14. 48 CFR 622.1408 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clause. 622.1408 Section 622.1408 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Employment of Workers with Disabilities 622.1408 Contract...

  15. 48 CFR 22.1202 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 22.1202 Section 22.1202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS... Contracts 22.1202 Policy. (a) When a service contract succeeds a contract for performance of the same or...

  16. 47 CFR 54.604 - Consortia, telecommunications services, and existing contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Consortia, telecommunications services, and existing contracts. 54.604 Section 54.604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Telecommunications Program § 54.604 Consortia, telecommunications services, and existing contracts. (a) Consortia. (1...

  17. 47 CFR 54.604 - Consortia, telecommunications services, and existing contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Consortia, telecommunications services, and existing contracts. 54.604 Section 54.604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Telecommunications Program § 54.604 Consortia, telecommunications services, and existing contracts. (a) Consortia. (1...

  18. Systemic inflammatory responses to maximal versus submaximal lengthening contractions of the elbow flexors.

    PubMed

    Peake, Jonathan M; Nosaka, Kazunori; Muthalib, Makii; Suzuki, Katsuhiko

    2006-01-01

    We compared changes in markers of muscle damage and systemic inflammation after submaximal and maximal lengthening muscle contractions of the elbow flexors. Using a cross-over design, 10 healthy young men not involved in resistance training completed a submaximal trial (10 sets of 60 lengthening contractions at 10% maximum isometric strength, 1 min rest between sets), followed by a maximal trial (10 sets of three lengthening contractions at 100% maximum isometric strength, 3 min rest between sets). Lengthening contractions were performed on an isokinetic dynamometer. Opposite arms were used for the submaximal and maximal trials, and the trials were separated by a minimum of two weeks. Blood was sampled before, immediately after, 1 h, 3 h, and 1-4 d after each trial. Total leukocyte and neutrophil numbers, and the serum concentration of soluble tumor necrosis factor-alpha receptor 1 were elevated after both trials (P < 0.01), but there were no differences between the trials. Serum IL-6 concentration was elevated 3 h after the submaximal contractions (P < 0.01). The concentrations of serum tumor necrosis factor-alpha, IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor and plasma C-reactive protein remained unchanged following both trials. Maximum isometric strength and range of motion decreased significantly (P < 0.001) after both trials, and were lower from 1-4 days after the maximal contractions compared to the submaximal contractions. Plasma myoglobin concentration and creatine kinase activity, muscle soreness and upper arm circumference all increased after both trials (P < 0.01), but were not significantly different between the trials. Therefore, there were no differences in markers of systemic inflammation, despite evidence of greater muscle damage following maximal versus submaximal lengthening contractions of the elbow flexors.

  19. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain cost or pricing data from the 8(a) contractor...

  20. 48 CFR 725.705 - Local procurement-contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement-contract... DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.705 Local procurement—contract clause. Local procurement may be undertaken in accordance with the provisions of 22 CFR...

  1. 48 CFR 725.705 - Local procurement-contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Local procurement-contract... DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.705 Local procurement—contract clause. Local procurement may be undertaken in accordance with the provisions of 22 CFR...

  2. Differential regulation of smooth muscle contraction in rabbit internal anal sphincter by substance P and bombesin.

    PubMed

    Bitar, K N; Hillemeier, C; Biancani, P

    1990-01-01

    Substance P and bombesin induce contraction of isolated IAS smooth muscle cells by different intracellular mechanisms. The cells contracted in a dose dependent manner to both peptides. The kinetics of contraction were different. Substance P induced contraction peaked at 30 seconds and declined in a time dependent manner while bombesin induced contraction peaked at 30 seconds and was maintained for up to 8 minutes. The absence of extracellular calcium in the medium (0 calcium and 2 mM EGTA) had no affect on substance P induced contraction while it blocked bombesin induced contraction. Substance P induced contraction was blocked by the calmodulin antagonist W7 (10(-9)M) and was not affected by the PKC antagonist H7 (10(-6)M). Bombesin induced contraction was blocked by the PKC antagonist H7 and was not affected by the calmodulin antagonist W7. Our data indicate that substance P induces a transient contraction utilizing intracellular calcium and a calmodulin dependent pathway, while bombesin induces a sustained contraction utilizing calcium from extracellular sources and a calmodulin independent pathway.

  3. 48 CFR 1819.708-70 - NASA solicitation provision and contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA solicitation provision and contract clause. 1819.708-70 Section 1819.708-70 Federal Acquisition Regulations System... Business Subcontracting Program 1819.708-70 NASA solicitation provision and contract clause. (a) The...

  4. 48 CFR 1819.708-70 - NASA solicitation provision and contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA solicitation provision and contract clause. 1819.708-70 Section 1819.708-70 Federal Acquisition Regulations System... Business Subcontracting Program 1819.708-70 NASA solicitation provision and contract clause. (a) The...

  5. 48 CFR 1819.708-70 - NASA solicitation provision and contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA solicitation provision and contract clause. 1819.708-70 Section 1819.708-70 Federal Acquisition Regulations System... Business Subcontracting Program 1819.708-70 NASA solicitation provision and contract clause. (a) The...

  6. 48 CFR 1819.708-70 - NASA solicitation provision and contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA solicitation provision and contract clause. 1819.708-70 Section 1819.708-70 Federal Acquisition Regulations System... Business Subcontracting Program 1819.708-70 NASA solicitation provision and contract clause. (a) The...

  7. 42 CFR 438.356 - State contract options.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false State contract options. 438.356 Section 438.356 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE External Quality Review § 438.356 State contract options...

  8. Defense Procurement: An Analysis of Contract Management Internal Controls

    DTIC Science & Technology

    2015-03-22

    monitoring activities component of the internal control framework. Acquisition Research Program Graduate School of Business & Public Policy - 7...Research Program Graduate School of Business & Public Policy - 24 - Naval Postgraduate School Tan, L. H. J. (2013). An analysis of internal controls and...Naval Postgraduate School, Monterey, CA 93943. Defense Procurement: An Analysis of Contract Management Internal Controls 22 March 2015 Dr. Juanita

  9. Analysis of consultants' NHS and private incomes in England in 2003/4

    PubMed Central

    Morris, Stephen; Elliott, Bob; Ma, Ada; McConnachie, Alex; Rice, Nigel; Skåtun, Diane; Sutton, Matt

    2008-01-01

    Summary Objective Consultants employed by the NHS in England are allowed to undertake private practice to supplement their NHS income. Until the introduction of a new contract from October 2003, those employed on full-time contracts were allowed to earn private incomes no greater than 10% of their NHS income. In this paper we investigate the magnitude and determinants of consultants' NHS and private incomes. Design Quantitative analysis of financial data. Setting A unique, anonymized, non-disclosive dataset derived from tax returns for a sample of 24,407 consultants (92.3% of the total) in England for the financial year 2003/4. Main outcome methods The conditional mean total, NHS and private incomes earned by age group, type of contract, specialty and region of place of work. Results The mean annual total, NHS and private incomes across all consultants in 2003/4 were £110,773, £76,628 and £34,144, respectively. Incomes varied by age, type of contract, specialty and region of place of work. The ratio of mean private to NHS income for consultants employed on a full-time contract was 0.26. The mean private income across specialties ranged from £5,144 (for paediatric neurology) to £142,723 (plastic surgery). There was a positive association between mean private income and NHS waiting lists across specialties. Conclusions Consultants employed on full-time contracts on average exceeded the limits on private income stipulated by the 10% rule. Specialty is a more important determinant of income than the region in which the consultant works. Further work is required to explore the association between mean private income and waiting lists. PMID:18591691

  10. 42 CFR 405.415 - Requirements of the private contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Requirements of the private contract. 405.415 Section 405.415 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Private Contracts § 405.415...

  11. 42 CFR 405.455 - Application to Medicare+Choice contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Application to Medicare+Choice contracts. 405.455 Section 405.455 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Private Contracts § 405.455...

  12. Automated Non-invasive Video-Microscopy of Oyster Spat Heart Rate during Acute Temperature Change: Impact of Acclimation Temperature

    PubMed Central

    Domnik, Nicolle J.; Polymeropoulos, Elias T.; Elliott, Nicholas G.; Frappell, Peter B.; Fisher, John T.

    2016-01-01

    We developed an automated, non-invasive method to detect real-time cardiac contraction in post-larval (1.1–1.7 mm length), juvenile oysters (i.e., oyster spat) via a fiber-optic trans-illumination system. The system is housed within a temperature-controlled chamber and video microscopy imaging of the heart was coupled with video edge-detection to measure cardiac contraction, inter-beat interval, and heart rate (HR). We used the method to address the hypothesis that cool acclimation (10°C vs. 22°C—Ta10 or Ta22, respectively; each n = 8) would preserve cardiac phenotype (assessed via HR variability, HRV analysis and maintained cardiac activity) during acute temperature changes. The temperature ramp (TR) protocol comprised 2°C steps (10 min/experimental temperature, Texp) from 22°C to 10°C to 22°C. HR was related to Texp in both acclimation groups. Spat became asystolic at low temperatures, particularly Ta22 spat (Ta22: 8/8 vs. Ta10: 3/8 asystolic at Texp = 10°C). The rate of HR decrease during cooling was less in Ta10 vs. Ta22 spat when asystole was included in analysis (P = 0.026). Time-domain HRV was inversely related to temperature and elevated in Ta10 vs. Ta22 spat (P < 0.001), whereas a lack of defined peaks in spectral density precluded frequency-domain analysis. Application of the method during an acute cooling challenge revealed that cool temperature acclimation preserved active cardiac contraction in oyster spat and increased time-domain HRV responses, whereas warm acclimation enhanced asystole. These physiologic changes highlight the need for studies of mechanisms, and have translational potential for oyster aquaculture practices. PMID:27445833

  13. MAGIC reveals a complex morphology within the unidentified gamma-ray source HESS J1857+026

    NASA Astrophysics Data System (ADS)

    MAGIC Collaboration; Aleksić, J.; Ansoldi, S.; Antonelli, L. A.; Antoranz, P.; Babic, A.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Carmona, E.; Carosi, A.; Carreto Fidalgo, D.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Caneva, G.; De Lotto, B.; Delgado Mendez, C.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher, D.; Elsaesser, D.; Farina, E.; Ferenc, D.; Fonseca, M. V.; Font, L.; Frantzen, K.; Fruck, C.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Godinović, N.; González Muñoz, A.; Gozzini, S. R.; Hadasch, D.; Hayashida, M.; Herrera, J.; Herrero, A.; Hildebrand, D.; Hose, J.; Hrupec, D.; Idec, W.; Kadenius, V.; Kellermann, H.; Klepser, S.; Kodani, K.; Konno, Y.; Krause, J.; Kubo, H.; Kushida, J.; La Barbera, A.; Lelas, D.; Lewandowska, N.; Lindfors, E.; Lombardi, S.; López, M.; López-Coto, R.; López-Oramas, A.; Lorenz, E.; Lozano, I.; Makariev, M.; Mallot, K.; Maneva, G.; Mankuzhiyil, N.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Meucci, M.; Miranda, J. M.; Mirzoyan, R.; Moralejo, A.; Munar-Adrover, P.; Nakajima, D.; Niedzwiecki, A.; Nilsson, K.; Nishijima, K.; Noda, K.; Nowak, N.; de Oña Wilhelmi, E.; Orito, R.; Overkemping, A.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Partini, S.; Persic, M.; Prada, F.; Prada Moroni, P. G.; Prandini, E.; Preziuso, S.; Puljak, I.; Reinthal, R.; Rhode, W.; Ribó, M.; Rico, J.; Rodriguez Garcia, J.; Rügamer, S.; Saggion, A.; Saito, T.; Saito, K.; Satalecka, K.; Scalzotto, V.; Scapin, V.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Spanier, F.; Stamatescu, V.; Stamerra, A.; Steinbring, T.; Storz, J.; Strzys, M.; Sun, S.; Surić, T.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Thaele, J.; Tibolla, O.; Torres, D. F.; Toyama, T.; Treves, A.; Uellenbeck, M.; Vogler, P.; Wagner, R. M.; Zandanel, F.; Zanin, R.

    2014-11-01

    Aims: HESS J1857+026 is an extended TeV gamma-ray source that was discovered by H.E.S.S. as part of its Galactic plane survey. Given its broadband spectral energy distribution and its spatial coincidence with the young energetic pulsar PSR J1856+0245, the source has been put forward as a pulsar wind nebula (PWN) candidate. MAGIC has performed follow-up observations aimed at mapping the source down to energies approaching 100 GeV in order to better understand its complex morphology. Methods: HESS J1857+026 was observed by MAGIC in 2010, yielding 29 h of good quality stereoscopic data that allowed us to map the source region in two separate ranges of energy. Results: We detected very-high-energy gamma-ray emission from HESS J1857+026 with a significance of 12σ above 150 GeV. The differential energy spectrum between 100 GeV and 13 TeV is described well by a power law function dN/dE = N0(E/1TeV)-Γ with N0 = (5.37 ± 0.44stat ± 1.5sys) × 10-12 (TeV-1 cm-2 s-1) and Γ = 2.16 ± 0.07stat ± 0.15sys, which bridges the gap between the GeV emission measured by Fermi-LAT and the multi-TeV emission measured by H.E.S.S.. In addition, we present a detailed analysis of the energy-dependent morphology of this region. We couple these results with archival multiwavelength data and outline evidence in favor of a two-source scenario, whereby one source is associated with a PWN, while the other could be linked with a molecular cloud complex containing an Hii region and a possible gas cavity.

  14. 40 CFR 160.10 - Applicability to studies performed under grants and contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Applicability to studies performed under grants and contracts. 160.10 Section 160.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS GOOD LABORATORY PRACTICE STANDARDS General Provisions § 160.10...

  15. Oil and Hazardous Material Cleanup Liability: A Study of Legal and Administrative Efficiency.

    DTIC Science & Technology

    1980-01-01

    sec. 1161 (1972). 6 extensive network of support equipment and the support people who contract, audit invoices, train, and manage budgets and programs...tediously describing the intricate aspects of documentation, auditing , forms, Ś The most notable "Superfund" type bill in the 96th Congress is H.R. 85. 10...Workshop on Reducing Tankbarge Pollution, 15 and 16 April 1980. (Typewritten). 21 the primary source of oil polution .16 Second, vessel source pollution

  16. 42 CFR 421.200 - Carrier functions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Carrier functions. 421.200 Section 421.200 Public...) MEDICARE PROGRAM MEDICARE CONTRACTING Carriers § 421.200 Carrier functions. A contract between CMS and a carrier specifies the functions to be performed by the carrier. The contract may include any or all of the...

  17. Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery.

    PubMed

    Satoh, H; Inui, J

    1984-01-27

    Histamine (10(-8)-10(-6) M) relaxed in a concentration-dependent manner the guinea-pig pulmonary artery which had been contracted by noradrenaline (5 X 10(-7) M). After the removal of endothelial cells (ETCs) histamine at the same concentrations did not cause relaxation but induced additional contraction. Both responses to histamine were antagonized by chlorpheniramine (3 X 10(-7) M). These results suggest that in the pulmonary artery histamine simultaneously stimulates H1-receptors located on both ETCs and smooth muscle cells. This results in two opposite effects, relaxation mediated by ETCs, and contraction.

  18. Age-related differences in twitch properties and muscle activation of the first dorsal interosseous.

    PubMed

    Miller, Jonathan D; Herda, Trent J; Trevino, Michael A; Sterczala, Adam J; Ciccone, Anthony B; Nicoll, Justin X

    2017-06-01

    To examine twitch force potentiation and twitch contraction duration, as well as electromyographic amplitude (EMG RMS ) and motor unit mean firing rates (MFR) at targeted forces between young and old individuals in the first dorsal interosseous (FDI). Ultrasonography was used to assess muscle quality. Twenty-two young (YG) (age=22.6±2.7years) and 14 older (OD) (age=62.1±4.7years) individuals completed conditioning contractions at 10% and 50% maximal voluntary contraction, (MVC) during which EMG RMS and MFRs were assessed. Evoked twitches preceded and followed the conditioning contractions. Ultrasound images were taken to quantify muscle quality (cross-sectional area [CSA] and echo intensity [EI]). No differences were found between young and old for CSA, pre-conditioning contraction twitch force, or MFRs (P>0.05). However, OD individuals exhibited greater EI and contraction duration (P<0.05), and EMG RMS (YG=35.4±8.7%, OD=43.4±13.2%; P=0.034). Twitch force potentiation was lower for OD (0.311±0.15N) than YG (0.619±0.26N) from pre- to post-50% conditioning contraction (P<0.001). Lower levels of potentiation with elongated contraction durations likely contributed to greater muscle activation during the conditioning contractions in the OD rather than altered MFRs. Ultrasonography suggested age-related changes in muscle structure contributed to altered contractile properties in the OD. Greater muscle activation requirements can have negative implications on fatigue resistance at low to moderate intensities in older individuals. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  19. 48 CFR 217.173 - Multiyear contracts for weapon systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... weapon systems. 217.173 Section 217.173 Federal Acquisition Regulations System DEFENSE ACQUISITION... Mulityear Contracting 217.173 Multiyear contracts for weapon systems. As authorized by 10 U.S.C. 2306b(h... contract for— (a) A weapon system and associated items, services, and logistics support for a weapon system...

  20. 75 FR 10645 - Low Pathogenic Avian Influenza; Voluntary Control Program and Payment of Indemnity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ...We are adopting as a final rule, with changes, an interim rule that amended the regulations by establishing, under the auspices of the National Poultry Improvement Plan, a voluntary program for the control of the H5/H7 subtypes of low pathogenic avian influenza in commercial poultry. As amended by this document, the rule provides that the amount of indemnity for which contract growers are eligible will be reduced by any payment they have already received on their contracts when poultry in their care are destroyed, clarifies the roles of cooperating State agencies with respect to H5/H7 low pathogenic avian influenza outbreaks, provides that consistency with humane euthanasia guidelines will be considered when selecting a method for the destruction of poultry, and provides additional guidance for cleaning and disinfecting an affected premises. The control program and indemnity provisions established by the interim rule are necessary to help ensure that the H5/H7 subtypes of low pathogenic avian influenza are detected and eradicated when they occur within the United States.

  1. Contracts and Management Services FY 1996 Site Support Program Plan: WBS 6.10.14. Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knoll, J.M. Jr.

    1995-09-01

    This is the Contracts and Management Services site support program plan for the US DOE Hanford site. The topics addressed in the program plan include a mission statement, program objectives, planning assumptions, program constraints, work breakdown structure, milestone list, milestone description sheets, and activity detail including cost accounting narrative summary, approved funding budget, and activity detailed description.

  2. Human urotensin-II is a potent spasmogen of primate airway smooth muscle

    PubMed Central

    Hay, Douglas W P; Luttmann, Mark A; Douglas, Stephen A

    2000-01-01

    The contractile profile of human urotensin-II (hU-II) was examined in primate airway and pulmonary vascular tissues. hU-II contracted tissues from different airway regions with similar potencies (pD2s from 8.6 to 9.2). However, there were regional differences in the efficacy of hU-II, with a progressive increase in the maximum contraction from trachea to smaller airway regions (from 9 to 41% of the contraction to 10 μM carbachol). hU-II potently contracted pulmonary artery tissues from different regions with similar potencies and efficacies: pD2s=8.7 to 9.3 and maximal contractions=79 to 86% of 60 mM KCl. hU-II potently contracted pulmonary vein preparations taken proximal to the atria, but had no effect in tissues from distal to the atria. This is the first report describing the contractile activity of hU-II in airways and suggests that the potential pathophysiological role of this peptide in lung diseases warrants investigation. PMID:10960062

  3. Specification Section 01065S ES&H for Service Contracts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kirsch, Greg C.

    2014-07-01

    Section Includes: Requirements and guidelines in performance of work concerning protection of environment and property, and the safety and health of Contractors, Sandia National Laboratories (SNL) and Department of Energy (DOE) employees, visitors to SNL, and members of the public. This Section is applicable only to Service Contracts that do not involve construction or construction-like activities. Construction and construction-like activities are covered by Section 01065, Environment, Safety and Health (ES&H) for Construction Contracts. The entire ES&H program shall focus on safe-by-design intent, understanding the technical basis for the work, identifying and controlling energy sources, unacceptable consequences, risk assessments, and positivemore » verification.« less

  4. 48 CFR 904.7101 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Definitions. 904.7101 Section 904.7101 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Prohibition on Contracting (National Security Program Contracts) 904.7101 Definitions. Effectively...

  5. 48 CFR 904.7101 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Definitions. 904.7101 Section 904.7101 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Prohibition on Contracting (National Security Program Contracts) 904.7101 Definitions. Effectively...

  6. 48 CFR 1223.7000 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1223.7000 Section 1223.7000 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  7. 48 CFR 1223.7000 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 1223.7000 Section 1223.7000 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  8. 48 CFR 1223.7000 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clauses. 1223.7000 Section 1223.7000 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  9. 48 CFR 1615.402 - Pricing policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Pricing policy. 1615.402... Contract Pricing 1615.402 Pricing policy. Pricing of FEHB contracts is governed by 5 U.S.C. 8902(i), 5 U.S... for which the FEHB Program premiums for the contract term will be less than the threshold at FAR 15...

  10. 48 CFR 22.1003-1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1003-1 General. This subpart 22.10 applies to all Government contracts, the principal purpose of which... does not apply to individual contract requirements for services in contracts not having as their...

  11. Studies of Verbal Problem Solving. 1. Two Performance-Aiding Programs

    DTIC Science & Technology

    1977-09-01

    5. Effective Date of Contract 6. Contract Expiration Date 7. Amount of Contract 8. Contract Number 9. Principal Investigator 10 . Scientific...7 10 3. A Mystery Solved by Propositional Calculus 16 1v I. INTRODUCTION Certain intellectual tasks, such as estimating and combining prob...aids or without any special training, they get the right answer within 15 minutes or so (about 80% of one large psychology class solved it). A few

  12. Program on the combustion chemistry of low- and intermediate-Btu gas mixtures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1981-11-30

    Low and intermediate Btu (LBTU and IBTU) gas mixtures are essentially mixtures of CO, H/sub 2/ and CH/sub 4/ diluted with nitrogen and CO/sub 2/. Although the combustion properties of these three fuels have been extensively investigated and their individual combustion kinetics are reasonably well established, prediction techniques for applying these gas mixtures remain for the most part empirical. This program has aimed to bring together and apply some of the fundamental combustion parameters to the CO-H/sub 2/-CH/sub 4/ flame system with the hope of reducing some of this empiricism. Four topical reports have resulted from this program. This finalmore » report summarizes these reports and other activities undertaken in this program. This program was initiated June 22, 1976 under ERDA Contract No. E(49-18)-2406 and was later continued under DOE/PETC and DOE Contract No. DE-AC22-76ET10653.« less

  13. Handbook of Phase Transition Sulfides, Selenides and Tellurides,

    DTIC Science & Technology

    1984-07-01

    guidance and control. The Contracting Officer is Mrs. S. Williams, DESC, Dayton, Ohio. The Contracting Officers Technical Representative is Mr. H . C...higher temperature phase change where AgGaS2 becomes metallic. REFERENCES (AgGaS2 ) 1. H . Hahn, et.al., Z. Anorg. Chem., 271, 153 (1953). 2. M.V. Hobden...Phys. Soc. Japan, Vol. 23, 37 (1967). 10. H.H. Dorner, H.P. Geserich, and H . Rickert, Phys. Stat. Sol. (a), Vol. 37, K85 (1970). 11. P. Bruesch and J

  14. The Role of Frame Force in Quantum Detection

    DTIC Science & Technology

    2007-01-01

    42040) 10. C. H. Bennett, Quantum cryptography using any two nonorthogonal states, Phys. Rev. Lett. 68 (1992), no. 21, 3121–3124. MR 1 163 546 11. S ...SUBTITLE The Role of Frame Force in Quantum Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT...equivalent to a quantum detection problem from quantum mechanics. To this end we first reformulate Problem 1.2 in terms of orthonormal bases instead of 1

  15. 48 CFR 570.308 - Award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Award. 570.308 Section 570.308 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Contracting Procedures for Leasehold Interests in...

  16. 48 CFR 1823.1005 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clause. 1823.1005 Section 1823.1005 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  17. 47 CFR 76.108 - Indemnification contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Indemnification contracts. 76.108 Section 76.108 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... indemnify a cable system for liability resulting from failure to delete programming in accordance with the...

  18. 47 CFR 76.108 - Indemnification contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Indemnification contracts. 76.108 Section 76.108 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... indemnify a cable system for liability resulting from failure to delete programming in accordance with the...

  19. 48 CFR 1823.7101 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clause. 1823.7101 Section 1823.7101 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  20. 48 CFR 1823.1005 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clause. 1823.1005 Section 1823.1005 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  1. 48 CFR 1823.1005 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clause. 1823.1005 Section 1823.1005 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  2. 48 CFR 1823.7101 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clause. 1823.7101 Section 1823.7101 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL...

  3. 48 CFR 23.303 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract clause. 23.303 Section 23.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  4. 48 CFR 223.303 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 223.303 Section 223.303 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  5. 48 CFR 23.804 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract clauses. 23.804 Section 23.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  6. 48 CFR 223.7203 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clause. 223.7203 Section 223.7203 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  7. 48 CFR 23.1005 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract clause. 23.1005 Section 23.1005 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  8. 48 CFR 223.7203 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clause. 223.7203 Section 223.7203 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  9. 48 CFR 223.7106 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clause. 223.7106 Section 223.7106 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  10. 48 CFR 23.303 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract clause. 23.303 Section 23.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  11. 48 CFR 1223.303 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1223.303 Section 1223.303 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  12. 48 CFR 23.903 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract clause. 23.903 Section 23.903 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  13. 48 CFR 223.7103 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 223.7103 Section 223.7103 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  14. 48 CFR 223.303 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contract clause. 223.303 Section 223.303 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  15. 48 CFR 23.303 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 23.303 Section 23.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  16. 48 CFR 23.1005 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract clause. 23.1005 Section 23.1005 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  17. 48 CFR 223.7306 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clause. 223.7306 Section 223.7306 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  18. 48 CFR 223.7306 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clause. 223.7306 Section 223.7306 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  19. 48 CFR 223.303 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clause. 223.303 Section 223.303 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  20. 48 CFR 223.7103 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clause. 223.7103 Section 223.7103 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  1. 48 CFR 223.303 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clause. 223.303 Section 223.303 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  2. 48 CFR 23.1105 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract clause. 23.1105 Section 23.1105 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  3. 48 CFR 223.7203 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 223.7203 Section 223.7203 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  4. 48 CFR 1223.303 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 1223.303 Section 1223.303 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  5. 48 CFR 1223.303 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clause. 1223.303 Section 1223.303 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  6. 48 CFR 1523.303 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1523.303 Section 1523.303 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SOCIOECONOMIC PROGRAMS ENVIRONMENTAL, CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Hazardous Material and...

  7. Effects of multidimensional pelvic floor muscle training in healthy young women.

    PubMed

    Talasz, Helena; Kalchschmid, Elisabeth; Kofler, Markus; Lechleitner, Monika

    2012-03-01

    Cross-sectional and interventional study to assess pelvic floor muscle (PFM) function in healthy young nulliparous women and to determine the effects of a 3-month PFM training program with emphasis on co-contraction of PFM and anterolateral abdominal muscles and on correctly performed coughing patterns. PFM function was assessed by digital vaginal palpation in 40 volunteers and graded according to the 6-point Oxford grading scale. The PFM training program was comprised theoretical instruction, as well as verbal feedback during hands-on instruction and repeated training sessions focussing on strengthening PFM and anterolateral abdominal muscle co-contraction during forced expiration and coughing. At baseline, 30 women (75%) were able to perform normal PFM contractions at rest (Oxford scale score ≥ 3); only 4 of them (10%) presented additional involuntary PFM contractions before and during coughing. The remaining 10 women (25%) were unable to perform voluntary or involuntary PFM contractions. Mean Oxford scale score in the whole group was 3.3 ± 1.7. After completing the PFM training program, 29 women (72.5%) performed cough-related PFM contractions and group mean Oxford scale score increased significantly to 4.2 ± 1.0. The study shows that PFM dysfunction may be detected even in healthy young women. Multidimensional training, however, may significantly improve PFM function.

  8. Evidence for P(2)-purinoceptors contribution in H(2)O(2)-induced contraction of rat aorta in the absence of endothelium.

    PubMed

    Shen, J Z; Zheng, X F; Kwan, C Y

    2000-08-18

    H(2)O(2) can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H(2)O(2)-induced vasoconstriction could be functionally attributed to the activation of P(2)-purinoceptors in rat aorta and to explore its possible signaling mechanisms. Isometric tension recording of H(2)O(2) and ATP-induced contractions of rat aortic rings were compared in the absence or presence of various pharmacological tools to identify their possible common signaling pathways. Both H(2)O(2) and ATP induced transient phasic contractions in a concentration-dependent manner (1-1000 microM). Removal of endothelium potentiated the contractile responses to H(2)O(2) and to ATP. H(2)O(2) (30 microM)-induced phasic contraction could be abolished by catalase (800 U/ml), but not affected by SOD (150 U/ml), DMSO (5 mM) and apyrase (5 U/ml), suggesting no involvement of O(2)(-), hydroxyl free radicals and ATP release. Also, several receptor antagonists including phentolamine, atropine, methysergide and chlorpheniramine (each 3 microM) were without effect on H(2)O(2) (30 microM)-induced phasic contraction, suggesting no involvement of typical neurotransmitter release. However, both H(2)O(2) (30 microM) and ATP (1 mM)-induced phasic contractions not only presented homologous desensitization, but also showed heterogeneous desensitization. Furthermore, the phasic contractions in response to H(2)O(2) (30 microM) or ATP (100 microM) could be inhibited or abolished in a concentration dependent manner by RB-2 and suramin (10-100 microM), two widely used P(2)-purinoceptor antagonists, with only partial inhibition by Evans blue (300 microM), a moderately selective P(2x) receptor blocker, or by alpha-beta-methylene-ATP (100 microM), a selective P(2x) receptor desensitizer. On the other hand, both H(2)O(2) (30 microM) and ATP (100 microM)-induced phasic contractions were also attenuated, to different degree, by inhibitors of several enzymes including PLC, PKC, PLA(2) and cyclooxygenase. Lastly, removal of extracellular Ca(2+) or pretreatment with procaine (10 mM) and dantrolene (30 microM), two putative intracellular Ca(2+) release blockers, or with Ni(2+) (100 microM) and tetrandrine (5 microM), two Ca(2+) channel blockers, all significantly inhibited H(2)O(2) and ATP-induced contractions. However, nifedipine (1 microM), a voltage-dependent L-type Ca(2+) channel blocker, was without effect. Our results demonstrate that H(2)O(2)-induced phasic contraction of rat aorta involves, at least in part, the activation of P(2)-purinoceptors in the aortic smooth muscle cells

  9. 7 CFR 1410.53 - Executed CRP contract not in conformity with regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Executed CRP contract not in conformity with... RESERVE PROGRAM § 1410.53 Executed CRP contract not in conformity with regulations. If, after a CRP contract is approved by CCC, it is discovered that such CRP contract is found to contain material errors of...

  10. Mechanisms of boron fiber strengthening by thermal treatment

    NASA Technical Reports Server (NTRS)

    Dicarlo, J. A.

    1979-01-01

    The fracture strain for boron on tungsten fibers can be improved by heat treatment under vacuum or argon environments. The mechanical basis for this improvement is thermally-induced axial contraction of the entire fiber, whereby strength-controlling core flaws are compressed and fiber fracture strain increased by the value of the contraction strain. By highly sensitive measurements of fiber density and volume, the physical mechanisms responsible for contraction under both environments was identified as boron atom diffusion out of the fiber sheath. The fiber contracts because the average volume of the resulting microvoid was determined to be only 0.26 + or - 0.09 the average atomic volume of the removed atom. The basic and practical implications of these results are discussed with particular emphasis on the theory, use, and limitations of heat-induced contraction as a simple cost-effective secondary processing method.

  11. 48 CFR 923.903 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 923.903 Section 923.903 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

  12. 48 CFR 923.903 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 923.903 Section 923.903 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

  13. 48 CFR 923.903 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract clause. 923.903 Section 923.903 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

  14. 48 CFR 923.903 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clause. 923.903 Section 923.903 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

  15. 47 CFR 76.125 - Indemnification contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Indemnification contracts. 76.125 Section 76.125 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... programming in accordance with the provisions of this Subpart unless the licensee has a reasonable basis for...

  16. 47 CFR 76.125 - Indemnification contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Indemnification contracts. 76.125 Section 76.125 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... programming in accordance with the provisions of this Subpart unless the licensee has a reasonable basis for...

  17. 48 CFR 2115.070 - Negotiation authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Negotiation authority. 2115.070 Section 2115.070 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL... CONTRACTING BY NEGOTIATION 2115.070 Negotiation authority. The authority to negotiate FEGLI Program contracts...

  18. 48 CFR 23.406 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Solicitation provisions and contract clauses. 23.406 Section 23.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES...

  19. 48 CFR 1823.570-2 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clause. 1823.570-2 Section 1823.570-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES...

  20. 48 CFR 1823.570-2 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clause. 1823.570-2 Section 1823.570-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES...

  1. 48 CFR 23.406 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 23.406 Section 23.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES...

  2. 48 CFR 223.370-5 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clauses. 223.370-5 Section 223.370-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  3. 48 CFR 223.370-5 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clauses. 223.370-5 Section 223.370-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  4. 48 CFR 223.370-5 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 223.370-5 Section 223.370-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY...

  5. 48 CFR 23.406 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Solicitation provisions and contract clauses. 23.406 Section 23.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES...

  6. 50 CFR 81.12 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Contracts. 81.12 Section 81.12 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED...

  7. 41 CFR 51-10.149 - Program accessibility: Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.149 Program accessibility...

  8. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.150 Program accessibility...

  9. 41 CFR 51-10.149 - Program accessibility: Discrimination prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.149 Program accessibility...

  10. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.150 Program accessibility...

  11. 41 CFR 51-10.149 - Program accessibility: Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.149 Program accessibility...

  12. 41 CFR 51-10.149 - Program accessibility: Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.149 Program accessibility...

  13. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 10... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.150 Program accessibility...

  14. 48 CFR 970.1907 - The Small Business Subcontracting Program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false The Small Business... AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Small Business Programs 970.1907 The Small Business Subcontracting Program. ...

  15. 48 CFR 970.1907 - The Small Business Subcontracting Program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false The Small Business... AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Small Business Programs 970.1907 The Small Business Subcontracting Program. ...

  16. 48 CFR 970.1907 - The Small Business Subcontracting Program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false The Small Business... AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Small Business Programs 970.1907 The Small Business Subcontracting Program. ...

  17. 48 CFR 970.1907 - The Small Business Subcontracting Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false The Small Business... AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Small Business Programs 970.1907 The Small Business Subcontracting Program. ...

  18. 48 CFR 212.7002 - Pilot program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Pilot program. 212.7002... OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Pilot Program for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002 Pilot program. ...

  19. 48 CFR 212.7002 - Pilot program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pilot program. 212.7002... OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Pilot Program for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002 Pilot program. ...

  20. A Pilates exercise program with pelvic floor muscle contraction: Is it effective for pregnant women? A randomized controlled trial.

    PubMed

    Dias, Naiara T; Ferreira, Letícia R; Fernandes, Mariana G; Resende, Ana Paula M; Pereira-Baldon, Vanessa S

    2018-01-01

    The aim of this study was to evaluate the effectiveness of a Pilates exercise program with pelvic floor muscle (PFM) contraction compared to a conventional intervention in pregnant women. Fifty primiparous women, without gestational alterations, were randomized to the Pilates group (n = 25) and control group (n = 25). Interventions for both groups consisted of twice-weekly sessions of 1 h each during the period between the 14-16th and 32-34th gestational weeks. The Pilates group performed a Pilates exercises program with the addition of voluntary PFM contraction. Mat-based Pilates exercises were performed involving movement of the upper limbs, lower limbs and trunk in all sessions. The Control group walked for 10 min and performed strengthening exercises of the lower limbs, upper limbs, and trunk with resistance from an elastic band and body weight. Each woman was evaluated by an unblinded physiotherapist before and after intervention for primary (PFM strength using a manometer) and secondary (PFM strength using Oxford Scale, endurance and repeatability) outcomes. Covariance analysis (ANCOVA) was used to compare the groups using the baseline values as a covariate. Thirty-six women were included in the analysis. There were no differences between the groups for manometry. An increase in the PFM strength, endurance, and repeatability was only observed in the Pilates group. In addition, the Pilates group showed greater adherence to the intervention. Pilates exercise program with PFM contraction is not able to change the PFM strength assessed by manometer in pregnant women, but it improved adherence to the intervention. © 2017 Wiley Periodicals, Inc.

  1. Lightweight, high-frequency transformers

    NASA Technical Reports Server (NTRS)

    Schwarze, G. E.

    1983-01-01

    The 25-kVA space transformer was developed under contract by Thermal Technology Laboratory, Buffalo, N. Y. The NASA Lewis transformer technology program attempted to develop the baseline technology. For the 25-kVA transformer the input voltage was chosen as 200 V, the output voltage as 1500 V, the input voltage waveform as square wave, the duty cycle as continuous, the frequency range (within certain constraints) as 10 to 40 kHz, the operating temperatures as 85 deg. and 130 C, the baseplate temperature as 50 C, the equivalent leakage inductance as less than 10 micro-h, the operating environment as space, and the life expectancy as 10 years. Such a transformer can also be used for aircraft, ship and terrestrial applications.

  2. 48 CFR 570.303-4 - Changes to SFOs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Changes to SFOs. 570.303-4 Section 570.303-4 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Contracting Procedures for Leasehold...

  3. 48 CFR 570.303-1 - Preparing the SFO.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Preparing the SFO. 570.303-1 Section 570.303-1 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Contracting Procedures for Leasehold...

  4. 48 CFR 570.303-2 - Issuing the SFO.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Issuing the SFO. 570.303-2 Section 570.303-2 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Contracting Procedures for Leasehold...

  5. 48 CFR 2422.1408 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 2422.1408 Section 2422.1408 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Employment of the Handicapped 2422...

  6. 48 CFR 25.504 - Evaluation Examples.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROGRAMS FOREIGN ACQUISITION Evaluating Foreign Offers-Supply Contracts 25.504 Evaluation Examples. The... examples assume that the contracting officer has eliminated all offers that are unacceptable for reasons... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Evaluation Examples. 25...

  7. 48 CFR 323.7002 - Actions required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Actions required. 323.7002 Section 323.7002 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SOCIOECONOMIC PROGRAMS... WORKPLACE Safety and Health 323.7002 Actions required. (a) Contracting activities. The Contracting Officer...

  8. 42 CFR 52h.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Applicability. 52h.1 Section 52h.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS SCIENTIFIC PEER REVIEW OF RESEARCH GRANT APPLICATIONS AND RESEARCH AND DEVELOPMENT CONTRACT PROJECTS § 52h.1 Applicability. (a) This part...

  9. Effects of ankle joint position and submaximal muscle contraction intensity on soleus H-reflex modulation in young and older adults.

    PubMed

    Chen, Yung-Sheng; Zhou, Shi; Cartwright, Colleen

    2014-04-01

    This study investigated the effects of ankle joint position and submaximal contraction intensity on soleus (SOL) H-reflex modulation. Twenty young (25.1 ± 4.8 years) and 20 older adults (74.2 ± 5.1 years) performed plantar flexions during 10%, 30% and 50% maximal voluntary contractions (MVC) and at ankle positions of neutral (0°), plantar flexion (20°) and dorsiflexion (-20°) in a sitting position. The SOL H-reflex gain in older adults was relatively lower than that in young adults during 10%, 30% and 50% MVC. The SOL H-reflex gain was significantly affected by the intensity of plantar flexion in the respective ankle joint position in both age groups. The latency of H-reflex was prolonged in older adults and was ankle joint dependent in young adults. Young adults demonstrated a shorter duration of the H-reflex response than that of older adults. The results indicated that there were age-related changes in the SOL H-reflex during the ankle plantar flexors activities.

  10. Contraction induced h reflexes in the diagnosis of cervical radiculopathy.

    PubMed

    Bodofsky, Elliot B; Campellone, Joseph V; Cohen, Stephen J; Caten, Holly N; Schindelheim, Adam M

    2015-06-01

    To determine whether Contraction Induced H Reflexes (CIHR) can accurately detect cervical radiculopathy. Comparison of CIHR results with Needle Electromyography at academic outpatient Electromyography/Nerve Conduction laboratories. Participants were all patients over 18 with a needle electromyography diagnosis of cervical radiculopathy. Patients were tested for CIHR in at least two upper extremity muscles in electromyographically proven myotomes bilaterally. Patients were requested to perform a moderate contraction while stimulus was applied proximally (elbow or Erb's point). Outcome measures included H Reflex onset latency and side-to-side latency differences. These were compared against previously established normal values. Overall, 10 of 15 patients who met criteria for cervical radiculopathy showed CIHR abnormalities (sensitivity = 67%; 95% confidence interval, 43-91). Counting each side and level separately, CIHR identified 16/27 radiculopathies (sensitivity = 59.2%; 95% confidence interval, 40.6-77.8). Contraction Induced H Reflexes identified 1 possible radiculopathy not seen on electromyography (specificity = 98%; 95% confidence interval, 95-100). Contraction induced H Reflexes have a sensitivity and specificity for cervical radiculopathy similar to the resting Gastroc-Soleus H Reflex.

  11. 48 CFR 923.103 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ENVIRONMENT, CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Sustainable Acquisition 923.103... Construction Contracts; FAR 52.223-10, Waste Reduction Program; FAR 52.223-XX, Compliance with Environmental...

  12. A Female Urinary Diversion Device for Military Women in the Deployed Environment

    DTIC Science & Technology

    2016-10-27

    9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones...reported there were many opportunities for a FUDD due to unsanitary and challenging conditions. Implications for Military Nursing : This research...Contract PoP: 6/1/2011 - 5/31/2016 Customer: TRISERVICE NURSING RESEARCH PROGRAM Customer Contract ID: HU0001 -11-1-TS02 Contract Manager: Robinson

  13. 48 CFR 622.406-1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Policy. 622.406-1 Section 622.406-1 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS....406-1 Policy. The cognizant contracting activity is the contracting agency for the purposes of FAR 22...

  14. 48 CFR 2822.101-3 - Reporting labor disputes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Reporting labor disputes... Socioeconomic Programs APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Basic Labor Policies 2822.101-3 Reporting labor disputes. The office administering the contract shall report, directly to the contracting...

  15. 48 CFR 53.219 - Small Business Programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00), Small...

  16. 48 CFR 53.219 - Small Business Programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00), Small...

  17. 48 CFR 53.219 - Small Business Programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00), Small...

  18. 48 CFR 53.219 - Small Business Programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00), Small...

  19. 48 CFR 53.219 - Small Business Programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00), Small...

  20. Trajectory and Force Control of a Direct Drive Arm.

    DTIC Science & Technology

    1986-09-01

    NUMBER 7. AUTNOn(s) . CONTRACT OR GRANT Ity൓"s ) Chae H. An N00014-80- C -- . O , 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT...and notations are used: 0 -W, WV CW { o ][:][ x] c (2.9) Wd X C -" W, 0 -W, cy -"X C (2) _-t V Wz 0 C , 11 󈧏 W, wy W, 0 0 0 112 112 W 0[ W. I0l (2.10) 0...theorem is used to compute the inertia terms translated to the center of mass of the load. C (2.16) )M Ji = P1- tn[(#TE)l -- (ZT)] (2.17) Then, the

  1. Mechanisms of boron fiber strengthening by thermal treatment

    NASA Technical Reports Server (NTRS)

    Dicarlo, J. A.

    1979-01-01

    The fracture strain for boron on tungsten fibers was studied for improvement by heat treatment under vacuum or argon environments. The mechanical basis for this improvement is thermally-induced axial contraction of the entire fiber, whereby strength-controlling core flaws are compressed and fiber fracture strain increased by the value of the contraction strain. By highly sensitive measurements of fiber density and volume, the physical mechanism responsible for contraction under both environments was identified as boron atom diffusion out of the fiber sheath. The fiber contracts because the average volume of the resulting microvoid was determined to be only 0.26 plus or minus 0.09 the average atomic volume of the removed atom. The basic and practical implications of these results are discussed with particular emphasis on the theory, use, and limitations of heat-induced contraction as a simple cost-effective secondary processing method.

  2. 10 CFR 800.002 - Program management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

  3. 10 CFR 800.002 - Program management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

  4. 10 CFR 800.002 - Program management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

  5. 10 CFR 800.002 - Program management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

  6. 10 CFR 800.002 - Program management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

  7. Implementation of the Air Program Information Management System (APIMS) Inspection Module

    DTIC Science & Technology

    2009-05-01

    7 5 T H A I R B A S E W I N G Implementation of the Air Program Information Management System (APIMS) Inspection Module 2009 Environment...Implementation of the Air Program Information Management System (APIMS) Inspection Module 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER

  8. 48 CFR 1835.016-71 - NASA Research Announcements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Research Announcements... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1835.016-71 NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and...

  9. 42 CFR 52h.12 - Other regulations that apply.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other regulations that apply. 52h.12 Section 52h.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS SCIENTIFIC PEER REVIEW OF RESEARCH GRANT APPLICATIONS AND RESEARCH AND DEVELOPMENT CONTRACT PROJECTS § 52h.12 Other...

  10. 48 CFR 352.270-3 - Indian preference program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Indian preference program... Indian preference program. As prescribed in 370.202(b), the Contracting Officer shall insert the following clause: Indian Preference Program (January 2006) (a) In addition to the requirements of the clause...

  11. 48 CFR 352.270-3 - Indian preference program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Indian preference program... Indian preference program. As prescribed in 370.202(b), the Contracting Officer shall insert the following clause: Indian Preference Program (January 2006) (a) In addition to the requirements of the clause...

  12. 48 CFR 352.270-3 - Indian preference program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Indian preference program... Indian preference program. As prescribed in 370.202(b), the Contracting Officer shall insert the following clause: Indian Preference Program (January 2006) (a) In addition to the requirements of the clause...

  13. 48 CFR 352.270-3 - Indian preference program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Indian preference program... Indian preference program. As prescribed in 370.202(b), the Contracting Officer shall insert the following clause: Indian Preference Program (January 2006) (a) In addition to the requirements of the clause...

  14. 48 CFR 352.270-3 - Indian preference program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Indian preference program... Indian preference program. As prescribed in 370.202(b), the Contracting Officer shall insert the following clause: Indian Preference Program (January 2006) (a) In addition to the requirements of the clause...

  15. 48 CFR 1419.803 - Selecting acquisitions for the 8(a) Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selecting acquisitions for the 8(a) Program. 1419.803 Section 1419.803 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration...

  16. 48 CFR 19.801 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 19.801 Section 19.801 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.801...

  17. 75 FR 71064 - Medicare Program; Proposed Changes to the Medicare Advantage and the Medicare Prescription Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... and the Medicare Prescription Drug Benefit Programs for Contract Year 2012 and Other Proposed Changes... for Contract Year 2012 and Other Proposed Changes'' which was filed for public inspection on November 10, 2010. FOR FURTHER INFORMATION CONTACT: Sabrina Ahmed, (410) 786-7499. SUPPLEMENTARY INFORMATION...

  18. Confidence Region for the Evaluation of HF DF Single Site Location Systems.

    DTIC Science & Technology

    1983-09-02

    CONTRACT ORt GRANT NUMBER(@) M.H. Reilly and J. Coran S. PERFORMING ORGANIZATION NAME AND ADDRESS WD PROGRAM ELEMENT. PROJECTAS Naval Research...1 DETERMINATION OF THE CONFIDENCE REGION....................2 COMPUTER PROGRAM FOR THE CONFIDENCE ELLIPSE..............5 EXAMPLES OF COMPUTER... PROGRAM OUTPUT......................6 DISCUSSION ................................................... 7 ACKNOWLEDGMENTS

  19. 48 CFR 2132.607 - Tax credit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Tax credit. 2132.607... Contract Debts 2132.607 Tax credit. FAR 32.607 has no practical application to FEGLI Program contracts. The... Government, contractors may not offset debts to the Fund by a tax credit that is solely a Government...

  20. 42 CFR 136.350 - Contracts with Urban Indian organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Contracts with Urban Indian organizations. 136.350 Section 136.350 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Indian Health Care Improvement Act Programs...

  1. 48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

  2. 48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

  3. 48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

  4. 48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

  5. 48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

  6. 42 CFR 136.350 - Contracts with Urban Indian organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Contracts with Urban Indian organizations. 136.350 Section 136.350 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Indian Health Care Improvement Act Programs...

  7. 42 CFR 136.350 - Contracts with Urban Indian organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Contracts with Urban Indian organizations. 136.350 Section 136.350 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Indian Health Care Improvement Act Programs...

  8. 42 CFR 136.350 - Contracts with Urban Indian organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Contracts with Urban Indian organizations. 136.350 Section 136.350 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Indian Health Care Improvement Act Programs...

  9. 42 CFR 136.350 - Contracts with Urban Indian organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Contracts with Urban Indian organizations. 136.350 Section 136.350 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Indian Health Care Improvement Act Programs...

  10. 48 CFR 319.270-1 - Solicitation provision and contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Solicitation provision and contract clause. 319.270-1 Section 319.270-1 Federal Acquisition Regulations System HEALTH AND HUMAN... Program, in solicitations that include the clause in FAR 52.219-9, Small Business Subcontracting Plan. The...

  11. 48 CFR 319.270-1 - Solicitation provision and contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Solicitation provision and contract clause. 319.270-1 Section 319.270-1 Federal Acquisition Regulations System HEALTH AND HUMAN... Program, in solicitations that include the clause in FAR 52.219-9, Small Business Subcontracting Plan. The...

  12. 48 CFR 2132.607 - Tax credit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Tax credit. 2132.607... Contract Debts 2132.607 Tax credit. FAR 32.607 has no practical application to FEGLI Program contracts. The... Government, contractors may not offset debts to the Fund by a tax credit that is solely a Government...

  13. Semiannual Technical Summary, 1 October 1990 - 31 March 1991 (Royal Norwegian Council for Scientific and Industrial Research)

    DTIC Science & Technology

    1991-05-01

    Ronal Njorwegian Council !,r ScrerithC arid Industrial RuseIarch R A YI~L ~ AD-A242 758 NORSAR Scientific Report No . 2-90/91 Semiannual Technical...Authorization T/9141/B/PKP ARPA Order No . 4138 AMD # 16 Program Code No . OF10 Name of Contractor Royal Norwegian Council for Scientific and Industrial ...PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION Defense Advanced -- "’able) Contract No . F08606-89-C-0005 Pae~h rjsct A ..... 8c. ADDRESS (Ci-tytate

  14. Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice

    PubMed Central

    Gadzinski, Jill A.; Guo, Jianxia; Philips, Brian J.; Basse, Per; Craig, Ethan K.; Bailey, Lisa; Comerci, John T.; Eiseman, Julie L.

    2017-01-01

    Background Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells. Methods CaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay. Pc 4 cellular uptake and intracellular distrubtion were determined. For in vitro Pc 4 photodynamic therapy cells were irradiated at 667nm at a fluence of 2.5 J/cm2 at 48 h. SCID mice were implanted with CaSki and ME-180 cells both subcutaneously and intracervically. Forty-eight h after Pc 4 photodynamic therapy was administered at 75 and 150 J/cm2. Results The IC50s for Pc 4 and Pc 4 photodynamic therapy for CaSki and ME-180 cells as monolayers were, 7.6μM and 0.016μM and >10μM and 0.026μM; as spheroids, IC50s of Pc 4 photodynamic therapy were, 0.26μM and 0.01μM. Pc 4 was taken up within cells and widely distributed in tumors and tissues. Intracervical photodynamic therapy resulted in tumor death, however mice died due to gastrointestinal toxicity. Photodynamic therapy resulted in subcutaneous tumor death and growth delay. Conclusions Pc 4 photodynamic therapy caused death within cervical cancer cells and xenografts, supporting development of Pc 4 photodynamic therapy for treatment of cervical cancer. Support: P30-CA47904, CTSI BaCCoR Pilot Program. PMID:28890844

  15. 42 CFR 52h.10 - What matters must be reviewed for solicited contract proposals?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... with respect to a contract project involving solicited contract proposals, unless the project concept... group has made recommendations concerning the scientific merit of the concept. (b) The awarding official... review of the project concept and the proposals has been completed. The request for proposals shall state...

  16. Ionized Absorbers in Active Galactic Nuclei and Very Steap Soft X-Ray Quasars

    NASA Technical Reports Server (NTRS)

    Fiore, Fabrizio; White, Nicholas (Technical Monitor)

    2000-01-01

    Steep soft X-ray (0.1-2 keV) quasars share several unusual properties: narrow Balmer lines, strong Fe II emission, large and fast X-ray variability, and a rather steep 2-10 keV spectrum. These intriguing objects have been suggested to be the analogues of Galactic black hole candidates in the high, soft state. We present here results from ASCA observations for two of these quasars: NAB 0205 + 024 and PG 1244 + 026. Both objects show similar variations (factor of approximately 2 in 10 ks), despite a factor of approximately 10 difference in the 0.5-10 keV luminosity (7.3 x 10(exp 43) erg/s for PG 1244 + 026 and 6.4 x 10(exp 44) erg/s for NAB 0205 + 024, assuming isotropic emission, H(sub 0) = 50.0 and q(sub 0) = 0.0). The X-ray continuum of the two quasars flattens by 0.5-1 going from the 0.1-2 keV band towards higher energies, strengthening recent results on another half-dozen steep soft X-ray active galactic nuclei. PG 1244 + 026 shows a significant feature in the '1-keV' region, which can be described either as a broad emission line centered at 0.95 keV (quasar frame) or as edge or line absorption at 1.17 (1.22) keV. The line emission could be a result of reflection from a highly ionized accretion disc, in line with the view that steep soft X-ray quasars are emitting close to the Eddington luminosity. Photoelectric edge absorption or resonant line absorption could be produced by gas outflowing at a large velocity (0.3-0.6 c).

  17. Dental plaque pH variation with regular soft drink, diet soft drink and high energy drink: an in vivo study.

    PubMed

    Jawale, Bhushan Arun; Bendgude, Vikas; Mahuli, Amit V; Dave, Bhavana; Kulkarni, Harshal; Mittal, Simpy

    2012-03-01

    A high incidence of dental caries and dental erosion associated with frequent consumption of soft drinks has been reported. The purpose of this study was to evaluate the pH response of dental plaque to a regular, diet and high energy drink. Twenty subjects were recruited for this study. All subjects were between the ages of 20 and 25 and had at least four restored tooth surfaces present. The subjects were asked to refrain from brushing for 48 hours prior to the study. At baseline, plaque pH was measured from four separate locations using harvesting method. Subjects were asked to swish with 15 ml of the respective soft drink for 1 minute. Plaque pH was measured at the four designated tooth sites at 5, 10 and 20 minutes intervals. Subjects then repeated the experiment using the other two soft drinks. pH was minimum for regular soft drink (2.65 ± 0.026) followed by high energy drink (3.39 ± 0.026) and diet soft drink (3.78 ± 0.006). The maximum drop in plaque pH was seen with regular soft drink followed by high energy drink and diet soft drink. Regular soft drink possesses a greater acid challenge potential on enamel than diet and high energy soft drinks. However, in this clinical trial, the pH associated with either soft drink did not reach the critical pH which is expected for enamel demineralization and dissolution.

  18. Protons act as a transmitter for muscle contraction in C. elegans.

    PubMed

    Beg, Asim A; Ernstrom, Glen G; Nix, Paola; Davis, M Wayne; Jorgensen, Erik M

    2008-01-11

    Muscle contraction is normally mediated by the release of neurotransmitters from motor neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to stimulate muscle contraction. During the C. elegans defecation motor program the posterior body muscles contract even in the absence of neuronal inputs or vesicular neurotransmission. In this study, we demonstrate that the space between the intestine and the muscle is acidified just prior to muscle contraction and that the release of caged protons is sufficient to induce muscle contraction. PBO-4 is a putative Na+/H+ ion exchanger expressed on the basolateral membrane of the intestine, juxtaposed to the posterior body muscles. In pbo-4 mutants the extracellular space is not acidified and the muscles fail to contract. The pbo-5 and pbo-6 genes encode subunits of a "cys-loop" proton-gated cation channel required for muscles to respond to acidification. In heterologous expression assays the PBO receptor is half-maximally activated at a pH of 6.8. The identification of the mechanisms for release and reception of proton signals establishes a highly unusual mechanism for intercellular communication.

  19. New FCC Mg–Zr and Mg–Zr–ti deuterides obtained by reactive milling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guzik, Matylda N., E-mail: matylda.guzik@ife.no; Deledda, Stefano; Sørby, Magnus H.

    2015-03-15

    Results for binary Mg–Zr and ternary Mg–Zr–Ti mixtures ball milled at room temperature under reactive deuterium atmosphere (5.6–6.7 MPa) are reported. X-ray and neutron powder diffraction combined with Rietveld refinements show that two new cubic phases were formed during milling. Mg{sub 0.40}Zr{sub 0.60}D{sub 1.78} and Mg{sub 0.40}Zr{sub 0.26}Ti{sub 0.34}D{sub 1.98} crystallize with disordered face centered cubic metal atom arrangements. Results of differential scanning calorimetry and termogravimetric measurements demonstrate that both deuterides desorb deuterium at lower temperatures than MgD{sub 2}, ZrD{sub 2} or TiD{sub 2}; 528 and 575 K in the Mg–Zr–D and Mg–Zr–Ti–D system, respectively. Interestingly, Mg{sub 0.40}Zr{sub 0.26}Ti{sub 0.34}D{submore » 1.98} stores deuterium reversibly at 673 K and 10 MPa of D{sub 2}. - Graphical abstract: High resolution SR-PXD patterns obtained for Mg{sub 0.40}Zr{sub 0.60}D{sub 1.78} and first time reported Mg{sub 0.40}Zr{sub 0.26}Ti{sub 0.34}D{sub 1.98}. - Highlights: • Synthesis and characterization of Mg{sub 0.40}Zr{sub 0.60}D{sub 1.78} and Mg{sub 0.40}Zr{sub 0.26}Ti{sub 0.34}D{sub 1.98}. • New deuterides obtained by milling under H{sub 2} gas pressure in the order of a few MPa. • Phases desorb deuterium at temperature lower than corresponding binary deuterides. • Mg{sub 0.40}Zr{sub 0.26}Ti{sub 0.34}D{sub 1.98} stores hydrogen reversibly at 673 K and 10 MPa of D{sub 2}.« less

  20. Contracts and management services site support program plan WBS 6.10.14

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knoll, J.M. Jr.

    1994-09-01

    Contracts and Management Services is recognized as the central focal point for programs having company or sitewide application in pursuit of the Hanford Missions`s financial and operational objectives. Contracts and Management Services actively pursues cost savings and operational efficiencies through: Management Standards by ensuring all employees have an accessible, integrated system of clear, complete, accurate, timely, and useful management control policies and procedures; Contract Reform by restructuring the contract, organization, and cost accounting systems to refocus Hanford contract activities on output products; Systems and Operations Evaluation by directing the Cost Reduction program, Great Ideas, and Span of Management activities; Programmore » Administration by enforcing conditions of Accountability (whether DEAR-based or FAR-based) for WHC, BCSR, ICF KH, and BHI; Contract Performance activities; chairing the WHC Cost Reduction Review Board; and analyzing companywide Performance Measures; Data Standards and Administration by establishing and directing the company data management program; giving direction to the major RL programs and mission areas for implementation of cost-effective and efficient data management practices; directing all operations, application, and interfaces contained within the Hanford PeopleCore System; directing accomplishment and delivery of TPA data management milestones; and directing the sitewide data management processes for Data Standards and the Data Directory.« less

  1. 42 CFR 421.205 - Termination by the Secretary.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Termination by the Secretary. 421.205 Section 421... (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE CONTRACTING Carriers § 421.205 Termination by the Secretary. (a) Cause for termination. The Secretary may terminate a contract with a carrier at any time if he or...

  2. 42 CFR 457.955 - Conditions necessary to contract as a managed care entity (MCE).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... separate child health program has administrative and management arrangements or procedures designed to... 42 Public Health 4 2012-10-01 2012-10-01 false Conditions necessary to contract as a managed care entity (MCE). 457.955 Section 457.955 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT...

  3. 42 CFR 457.955 - Conditions necessary to contract as a managed care entity (MCE).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... separate child health program has administrative and management arrangements or procedures designed to... 42 Public Health 4 2014-10-01 2014-10-01 false Conditions necessary to contract as a managed care entity (MCE). 457.955 Section 457.955 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT...

  4. Raman spectra and cross sections of ammonia, chlorine, hydrogen sulfide, phosgene, and sulfur dioxide toxic gases in the fingerprint region 400-1400 cm-1

    NASA Astrophysics Data System (ADS)

    Aggarwal, R. L.; Farrar, L. W.; Di Cecca, S.; Jeys, T. H.

    2016-02-01

    Raman spectra of ammonia (NH3), chlorine (Cl2), hydrogen sulfide (H2S), phosgene (COCl2), and sulfur dioxide (SO2) toxic gases have been measured in the fingerprint region 400-1400 cm-1. A relatively compact (<2'x2'x2'), sensitive, 532 nm 10 W CW Raman system with double-pass laser and double-sided collection was used for these measurements. Two Raman modes are observed at 934 and 967 cm-1 in NH3. Three Raman modes are observed in Cl2 at 554, 547, and 539 cm-1, which are due to the 35/35 35/37, and 37/37 Cl isotopes, respectively. Raman modes are observed at 870, 570, and 1151 cm-1 in H2S, COCl2, and SO2, respectively. Values of 3.68 ± 0.26x10-32 cm2/sr (3.68 ± 0.26x10-36 m2/sr), 1.37 ± 0.10x10-30 cm2/sr (1.37 ± 0.10x10-34 m2/sr), 3.25 ± 0.23x10-31 cm2/sr (3.25 ± 0.23x10-35 m2/sr), 1.63 ± 0.14x10-30 cm2/sr (1.63 ± 0.14x10-34 m2/sr), and 3.08 ± 0.22x10-30 cm2/sr (and 3.08 ± 0.22x10-34 m2/sr) were determined for the differential Raman cross section of the 967 cm-1 mode of NH3, sum of the 554, 547, and 539 cm-1 modes of Cl2, 870 cm-1 mode of H2S, 570 cm-1 mode of COCl2, and 1151 cm-1 mode of SO2, respectively, using the differential Raman cross section of 3.56 ± 0.14x10-31 cm2/sr (3.56 ± 0.14x10-35 m2/sr) for the 1285 cm-1 mode of CO2 as the reference.

  5. 76 FR 58152 - Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... up to 4 years for supplies and services required for management, maintenance, and operation of... Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C. chapter 35). List of... of the agency shall provide copies of the notification to the Office of Management and Budget at...

  6. Systems Engineering Capstone Marketplace

    DTIC Science & Technology

    2016-02-01

    Contract Number: HQ0034-13-D-0004 Report No. SERC -2016-TR-102 February 2016 UNCLASSIFIED Systems Engineering Capstone Marketplace A013...Technical Report SERC -2016-TR-102 February 2016 Principal Investigator: Michael DeLorme Megan Clifford Stevens Institute of Technology...WHS TO 026 RT 43 WHS TO 027.RT 042 Report No. SERC -2013-TR-102 July 16, 2014 UNCLASSIFIED

  7. 41 CFR 51-10.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR... CONDUCTED BY THE COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.151 Program...

  8. 41 CFR 51-10.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR... CONDUCTED BY THE COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.151 Program...

  9. 41 CFR 51-10.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR... CONDUCTED BY THE COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED § 51-10.151 Program...

  10. Why is cytoskeletal contraction required for cardiac fusion before but not after looping begins?

    NASA Astrophysics Data System (ADS)

    Shi, Yunfei; Varner, Victor D.; Taber, Larry A.

    2015-02-01

    Cytoskeletal contraction is crucial to numerous morphogenetic processes, but its role in early heart development is poorly understood. Studies in chick embryos have shown that inhibiting myosin-II-based contraction prior to Hamburger-Hamilton (HH) stage 10 (33 h incubation) impedes fusion of the mesodermal heart fields that create the primitive heart tube (HT), as well as the ensuing process of cardiac looping. If contraction is inhibited at or after looping begins at HH10, however, fusion and looping proceed relatively normally. To explore the mechanisms behind this seemingly fundamental change in behavior, we measured spatiotemporal distributions of tissue stiffness, stress, and strain around the anterior intestinal portal (AIP), the opening to the foregut where contraction and cardiac fusion occur. The results indicate that stiffness and tangential tension decreased bilaterally along the AIP with distance from the embryonic midline. The gradients in stiffness and tension, as well as strain rate, increased to peaks at HH9 (30 h) and decreased afterward. Exposure to the myosin II inhibitor blebbistatin reduced these effects, suggesting that they are mainly generated by active cytoskeletal contraction, and finite-element modeling indicates that the measured mechanical gradients are consistent with a relatively uniform contraction of the endodermal layer in conjunction with constraints imposed by the attached mesoderm. Taken together, our results suggest that, before HH10, endodermal contraction pulls the bilateral heart fields toward the midline where they fuse to create the HT. By HH10, however, the fusion process is far enough along to enable apposing cardiac progenitor cells to keep ‘zipping’ together during looping without the need for continued high contractile forces. These findings should shed new light on a perplexing question in early heart development.

  11. 40 CFR 464.35 - Pretreatment standards for existing sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....84 2.86 Zinc (T) 10.8 4.07 TTO 13.2 4.3 Oil and Grease (for alternate monitoring) 330 110 (2....0576 Zinc (T) 0.217 0.0827 TTO 0.0797 0.026 Oil and grease (for alternate monitoring) 4.43 1.48 (h... Zinc (T) 0.178 0.0673 TTO 0.0257 0.00838 Oil and grease (for alternate monitoring) 5.46 1.82 (2...

  12. 40 CFR 464.35 - Pretreatment standards for existing sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....84 2.86 Zinc (T) 10.8 4.07 TTO 13.2 4.3 Oil and Grease (for alternate monitoring) 330 110 (2....0576 Zinc (T) 0.217 0.0827 TTO 0.0797 0.026 Oil and grease (for alternate monitoring) 4.43 1.48 (h... Zinc (T) 0.178 0.0673 TTO 0.0257 0.00838 Oil and grease (for alternate monitoring) 5.46 1.82 (2...

  13. All Prime Contract Awards by State or Country, Place, and Contractor, FY83, Part 5 (LaGrange, Indiana-Escanaba, Michigan).

    DTIC Science & Technology

    1983-01-01

    N00104-83-CA014 B C A 1 2 2 1361 000 AS DEPTH CHARGE EXPLOSIVE COMPO 8 A 3 4 J 018 1 B J 1 J 174 2 E JA116 4000 N00104-83-CA014 B C A 1 2 2 1386 000 A6... EXPLOSIVE ORD DISPOSAL TOOL- 8 A 6 4 J 018 1 B J 1 E 84 2 A JA116 1398 N00104-63-CA026 B C A 1 3 2 1361 000 AS DEPTH CHARGE EXPLOSIVE COMPO 8 A 3 4 J...CA088 B C A 1 2 2 1356 000 AS TORPEDO EXPLOSIVE COMPONENTS 8 A 3 5 A 1001 5 B J 1 H 195 2 G PAIOt A700 N00140-83-CBA83 B C Z 1 2 2 R414 000 51 MOT

  14. 48 CFR 952.219-70 - DOE Mentor-Protege program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false DOE Mentor-Protege program... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.219-70 DOE Mentor.... DOE Mentor-Protege Program (MAY 2000) The Department of Energy has established a Mentor-Protege...

  15. 48 CFR 1452.226-71 - Indian Preference Program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Indian Preference Program... Indian Preference Program. As prescribed in 1426.7003(b), insert the following clause in all... work under the contract will be performed in whole or in part on or near an Indian reservation(s). The...

  16. 48 CFR 1452.226-71 - Indian Preference Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Indian Preference Program... Indian Preference Program. As prescribed in 1426.7003(b), insert the following clause in all... work under the contract will be performed in whole or in part on or near an Indian reservation(s). The...

  17. 48 CFR 1452.226-71 - Indian Preference Program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Indian Preference Program... Indian Preference Program. As prescribed in 1426.7003(b), insert the following clause in all... work under the contract will be performed in whole or in part on or near an Indian reservation(s). The...

  18. 48 CFR 1452.226-71 - Indian Preference Program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Indian Preference Program... Indian Preference Program. As prescribed in 1426.7003(b), insert the following clause in all... work under the contract will be performed in whole or in part on or near an Indian reservation(s). The...

  19. 48 CFR 1452.226-71 - Indian Preference Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Indian Preference Program... Indian Preference Program. As prescribed in 1426.7003(b), insert the following clause in all... work under the contract will be performed in whole or in part on or near an Indian reservation(s). The...

  20. Phosphorylation of h1 Calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor

    PubMed Central

    2012-01-01

    Background The timely onset of powerful uterine contractions during parturition occurs through thick and thin filament interactions, similar to other smooth muscle tissues. Calponin is one of the thin filament proteins. Phosphorylation of calponin induced by PKC-epsilon can promote the contraction of vascular smooth muscle. While the mechanism by which calponin regulates the contraction of pregnant myometrium has rarely been explored. Here, we explore whether PKC-epsilon/h1 calponin pathway contribute to regulation of myometrial contractility and development of parturition. Methods We detected the expression of h1 calponin, phosphorylated h1 calponin, PKC-epsilon and phosphorylated PKC-epsilon in the different stages of mice during pregnancy and in labor by the method of western blot and recorded the contraction activity of myometrium strips at the 19th day during pregnancy with different treatments by the organ bath experiments. Results The level of the four proteins including h1 calponin, phosphorylated h1 calponin, PKC-epsilon and phosphorylated PKC-epsilon was significantly increased in pregnant mice myometrium as compared with that in nonpregnant mice. The ratios of phosphorylated h1 calponin/h1 calponin and phosphorylated PKC-epsilon/PKC-epsilon were reached the peak after the onset of labor in myometrium in the mice. After the treatment of more than 10(9-) mol/L Psi-RACK (PKC-epsilon activator), the contractility of myometrium strips from mice was reinforced and the level of phosphorylated h1 calponin increased at the same time which could be interrupted by the specific inhibitor of PKC-epsilon. Meanwhile, the change of the ratio of phosphorylated h1 calponin/h1 calponin was consistent with that of contraction force of mice myometrium strips. Conclusions These data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility. PMID:22551221

  1. Organizational justice is related to heart rate variability in white-collar workers, but not in blue-collar workers-findings from a cross-sectional study.

    PubMed

    Herr, Raphael M; Bosch, Jos A; van Vianen, Annelies E M; Jarczok, Marc N; Thayer, Julian F; Li, Jian; Schmidt, Burkhard; Fischer, Joachim E; Loerbroks, Adrian

    2015-06-01

    Perceived injustice at work predicts coronary heart disease. Vagal dysregulation represents a potential psychobiological pathway. We examined associations between organizational justice and heart rate variability (HRV) indicators. Grounded in social exchange and psychological contract theory, we tested predictions that these associations are more pronounced among white-collar than among blue-collar workers. Cross-sectional data from 222 blue-collar and 179 white-collar men were used. Interactional and procedural justice were measured by questionnaire. Ambulatory HRV was assessed across 24 h. Standardized regression coefficients (β) were calculated. Among white-collar workers, interactional justice showed positive relationships with 24-h HRV, which were strongest during sleeping time (adjusted βs≥0.26; p values≤0.01). No associations were found for blue-collar workers. A comparable but attenuated pattern was observed for procedural justice. Both dimensions of organizational injustice were associated with lowered HRV among white-collar workers. The impact of justice and possibly its association with health seems to differ by occupational groups.

  2. 40 CFR 428.73 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... consecutive days shall not exceed— Metric units (kg/kkg of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH (1) (1) English units (lb/1,000 lb of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH... Average of daily values for 30 consecutive days shall not exceed— Metric units (kg/kkg of raw material...

  3. 40 CFR 428.73 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... consecutive days shall not exceed— Metric units (kg/kkg of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH (1) (1) English units (lb/1,000 lb of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH... Average of daily values for 30 consecutive days shall not exceed— Metric units (kg/kkg of raw material...

  4. 48 CFR 19.809 - Preaward considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Preaward considerations. 19.809 Section 19.809 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a...

  5. Gemini experiment S026

    NASA Technical Reports Server (NTRS)

    Medved, D. B.

    1971-01-01

    The results of the reduction and analysis of data obtained from the S026 experiment from Gemini 10 and 11 flights are presented. The electron and ion sensors were continuously operative throughout both missions from shroud removal (about 6 minutes after Agena liftoff to power-down conditions one week later). Data on ion and electron currents, electron temperature, and vehicle potential were obtained at a sample rate of 32 times per second on positive ions for each of two ion sensors and once every 1.067 seconds for the electron sensor. Only the data reduction of the Gemini plasma wake measurements comprising roughly twenty minutes of data for six maneuvers programed for wake measurements are considered. The intermediate depletion zone, between 1 and 10 vehicle radii downstream from the object, is emphasized. The smallest characteristic radius of interest is 1.34 feet and the largest is 5 feet. This implies a separation span extending from approximately 1.5 feet at the closest approach to at least 50 feet into the far field.

  6. Defense Contracting: Actions Needed to Explore Additional Opportunities to Gain Efficiencies in Acquiring Foreign Language Support

    DTIC Science & Technology

    2013-02-25

    Directive 5160.41E, Defense Language Program . 10GAO-11-456. Page 5 GAO-13-251R Defense Contracting types of foreign language support that DOD has acquired...Language Transformation Roadmap, (January 2005), and Department of Defense Directive 5160.41E, Defense Language Program . Page 15 GAO-13-251R Defense...examines the use of public funds; evaluates federal programs and policies; and provides analyses, recommendations, and other assistance to help

  7. 48 CFR 1426.7103-2 - Requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Requirements. 1426.7103-2 Section 1426.7103-2 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-2 Requirements. The contracting...

  8. 49 CFR 26.39 - Fostering small business participation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Fostering small business participation. 26.39... BUSINESS ENTERPRISES IN DEPARTMENT OF TRANSPORTATION FINANCIAL ASSISTANCE PROGRAMS Administrative Requirements for DBE Programs for Federally-Assisted Contracting § 26.39 Fostering small business participation...

  9. 49 CFR 26.39 - Fostering small business participation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Fostering small business participation. 26.39... BUSINESS ENTERPRISES IN DEPARTMENT OF TRANSPORTATION FINANCIAL ASSISTANCE PROGRAMS Administrative Requirements for DBE Programs for Federally-Assisted Contracting § 26.39 Fostering small business participation...

  10. 48 CFR 970.3002 - CAS program requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false CAS program requirements. 970.3002 Section 970.3002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Cost Accounting Standards Administration 970...

  11. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS 2005-2014 TOBACCO TRANSITION PROGRAM Tobacco Transition...

  12. Medical Surveillance Monthly Report (MSMR). Volume 16, Number 4, April 2009

    DTIC Science & Technology

    2009-04-01

    April 2009 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR (S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER...Hepatitis A (μ: 10) Hantavirus disease (μ: 3) Brucellosis (μ: 2) E. coli O157:H7 (μ: 3) West Nile virus (μ: 6) Dengue fever (μ: 4) Ehrlichiosis (μ...uenzae, invasive 0 0 2 2 14 Hantavirus disease 0 6 2 0 0 Heat exhaustion 542 727 566 547 452 Heat stroke 196 163 128 133 145 Hemorrhagic fever 0 0 0

  13. 500 Contractors Receiving the Largest Dollar Volume of Prime Contract Awards for RDT&E Fiscal Year 1989

    DTIC Science & Technology

    1989-01-01

    COMPUTER SCIENCES CORPORATION 84 B AVCO RESEARCH LABORATORY INC 109 B CONTEL FEDERAL SYSTEMS INC 439 B B D SYSTEMS INC 427 B CONTRAVES GOERZ CORPORATION...2,121 Costa Mesa California 2,026 Santa Ana California 52 450 COMPRHENSIVE TECHNOLOGIES INTL S 2,109 * Chant illy Virginia 2,109 427 CONTRAVES GOERZ

  14. REACH. Teacher's Guide, Volume I. Secondary Program Management.

    ERIC Educational Resources Information Center

    Morris, James Lee; And Others

    Designed for use with individualized instructional units (CE 026 345 and CE 026 348-350) in the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this secondary teacher's guide is devoted to the establishment of standard instructional procedures. Following an introductory section, sections provide…

  15. Protons act as a transmitter for muscle contraction in C. elegans

    PubMed Central

    Beg, Asim A.; Ernstrom, Glen G.; Nix, Paola; Davis, M. Wayne; Jorgensen, Erik M.

    2008-01-01

    Muscle contraction is normally mediated by the release of neurotransmitters from motor neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to stimulate muscle contraction. During the C. elegans defecation motor program the posterior body muscles contract even in the absence of neuronal inputs or vesicular neurotransmission. In this study, we demonstrate that the space between the intestine and the muscle is acidified just prior to muscle contraction and that the release of caged protons is sufficient to induce muscle contraction. PBO-4 is a putative Na+/H+ ion exchanger expressed on the basolateral membrane of the intestine, juxtaposed to the posterior body muscles. In pbo-4 mutants the extracellular space is not acidified and the muscles fail to contract. The pbo-5 and pbo-6 genes encode subunits of a ‘cys-loop’ proton-gated cation channel required for muscles to respond to acidification. In heterologous expression assays the PBO receptor is half-maximally activated at a pH of 6.8. The identification of the mechanisms for release and reception of proton signals establishes a highly unusual mechanism for intercellular communication. PMID:18191228

  16. Effects of a chitin binding vicilin from Erythrina velutina seeds on bean bruchid pests (Callosobruchus maculatus and Zabrotes subfasciatus).

    PubMed

    Teixeira, Fabiano M; Oliveira, Adeliana S; Macedo, Leonardo L P; Santos, Elizeu A; de Sales, Mauricio P

    2008-01-01

    Erythrina velutina vicilin, EvV, is a dimeric glycoprotein with Mr of 124.6 kDa. EvV was tested for anti-insect activity against bean bruchid larvae. EvV had LD(50) of 0.10% and ED(50) of 0.14% for Z. subfasciatus and LD(50) of 0.26% and ED(50) of 0.19% for C. maculatus. EvV was not digested by bean larvae enzymes until 12 h of incubation, and at 24 h EvV was more resistant to Z. subfasciatus enzymes.

  17. 77 FR 43723 - Energy Efficiency and Conservation Loan Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... communities by investing in energy efficiency, and (5) encouraging the use of renewable energy fuels for both... contracts. Impacts The new Subpart H. for the Energy Efficiency and Conservation Loan Program can have several economic impacts. The benefits include: (1) The value of purchased energy saved; (2) the value of...

  18. 48 CFR 1815.407-2 - Make-or-buy programs. (NASA supplements paragraph (e))

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Make-or-buy programs. (NASA supplements paragraph (e)) 1815.407-2 Section 1815.407-2 Federal Acquisition Regulations System... NEGOTIATION Contract Pricing 1815.407-2 Make-or-buy programs. (NASA supplements paragraph (e)) (e)(1) Make-or...

  19. 48 CFR 1815.407-2 - Make-or-buy programs. (NASA supplements paragraph (e))

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Make-or-buy programs. (NASA supplements paragraph (e)) 1815.407-2 Section 1815.407-2 Federal Acquisition Regulations System... NEGOTIATION Contract Pricing 1815.407-2 Make-or-buy programs. (NASA supplements paragraph (e)) (e)(1) Make-or...

  20. 48 CFR 252.225-7000 - Buy American Act-Balance of Payments Program Certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Buy American Act-Balance... PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7000 Buy American Act—Balance of Payments Program Certificate. Buy American Act—Balance of Payments Program Certificate (DEC 2009) (a...

  1. 48 CFR 1644.170 - Policy for FEHB Program subcontracting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy for FEHB Program subcontracting. 1644.170 Section 1644.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND...

  2. 48 CFR 1644.170 - Policy for FEHB Program subcontracting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Policy for FEHB Program subcontracting. 1644.170 Section 1644.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND...

  3. 48 CFR 1644.170 - Policy for FEHB Program subcontracting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Policy for FEHB Program subcontracting. 1644.170 Section 1644.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND...

  4. 48 CFR 1644.170 - Policy for FEHB Program subcontracting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy for FEHB Program subcontracting. 1644.170 Section 1644.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND...

  5. 48 CFR 919.7013 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Reports. 919.7013 Section... BUSINESS PROGRAMS The Department of Energy Mentor-Protege Program 919.7013 Reports. (a) Prior to performing... submit semi-annual reports to the cognizant contracting officer regarding the participating Mentor's...

  6. 48 CFR 919.7013 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Reports. 919.7013 Section... BUSINESS PROGRAMS The Department of Energy Mentor-Protege Program 919.7013 Reports. (a) Prior to performing... submit semi-annual reports to the cognizant contracting officer regarding the participating Mentor's...

  7. 48 CFR 919.7013 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Reports. 919.7013 Section... BUSINESS PROGRAMS The Department of Energy Mentor-Protege Program 919.7013 Reports. (a) Prior to performing... submit semi-annual reports to the cognizant contracting officer regarding the participating Mentor's...

  8. 48 CFR 19.505 - Rejecting Small Business Administration recommendations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Rejecting Small Business... REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.505 Rejecting Small Business Administration recommendations. (a) If the contracting officer rejects a recommendation...

  9. 48 CFR 19.505 - Rejecting Small Business Administration recommendations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Rejecting Small Business... REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.505 Rejecting Small Business Administration recommendations. (a) If the contracting officer rejects a recommendation...

  10. 48 CFR 19.505 - Rejecting Small Business Administration recommendations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Rejecting Small Business... REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.505 Rejecting Small Business Administration recommendations. (a) If the contracting officer rejects a recommendation...

  11. 7 CFR 1450.205 - Duration of contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Duration of contracts. 1450.205 Section 1450.205 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP...

  12. 7 CFR 1450.205 - Duration of contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Duration of contracts. 1450.205 Section 1450.205 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP...

  13. 7 CFR 1450.205 - Duration of contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Duration of contracts. 1450.205 Section 1450.205 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM (BCAP...

  14. 48 CFR 352.219-71 - Mentor-protégé program reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Mentor-protégé program... Clauses 352.219-71 Mentor-protégé program reporting requirements. As prescribed in 319.270-1(b), the Contracting Officer shall insert the following clause: Mentor-Protégé Program Reporting Requirements (January...

  15. 48 CFR 352.219-70 - Mentor-protégé program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Mentor-protégé program... Mentor-protégé program. As prescribed in 319.270-1(a), the Contracting Officer shall insert the following provision: Mentor-Protégé Program (January 2010) (a) Large business prime contractors serving as mentors in...

  16. Postprandial gastric antral contractions in patients with gastro-oesophageal reflux disease: a scintigraphic study.

    PubMed

    Barbieri, C L A; Troncon, L E A; Herculano, J R L; Aprile, L R O; Moraes, E R; Secaf, M; Dantas, R O

    2008-05-01

    Disturbed gastric contractility has been found in manometric studies in patients with gastro-oesophageal reflux disease (GORD), but the pathophysiological role of this abnormality is unclear. We aimed at assessing postprandial gastric antral contractions and its relationships with gastric emptying and gastro-oesophageal reflux in GORD patients. Fasted GORD patients (n = 13) and healthy volunteers (n = 13) ingested a liquid meal labelled with 72 MBq of 99mTechnetium-phytate. Gastric images were acquired every 10 min for 2 h, for measuring gastric emptying half time. Dynamic antral scintigraphy (one frame per second), performed for 4 min at 30-min intervals, allowed estimation of both mean dominant frequency and amplitude of antral contractions. In GORD patients (n = 10), acidic reflux episodes occurring 2 h after the ingestion of the same test meal were determined by ambulatory 24-h oesophageal pH monitoring. Gastric emptying was similar in GORD patients and controls (median; range: 82 min; 58-126 vs 80 min; 44-122 min; P = 0.38). Frequency of antral contractions was also similar in both groups (3.1 cpm; 2.8-3.6 vs 3.2 cpm; 2.4-3.8 cpm; P = 0.15). In GORD patients, amplitude of antral contractions was significantly higher than in controls (32.7%; 17-44%vs 23.3%; 16-43%; P = 0.01), and correlated positively with gastric emptying time (R(s) = 0.58; P = 0.03) and inversely with the number of reflux episodes (R(s) = -0.68; P = 0.02). Increased amplitude of postprandial gastric antral contractions in GORD may comprise a compensatory mechanism against delayed gastric emptying and a defensive factor against acidic gastro-oesophageal reflux.

  17. Hydrogen peroxide increases depolarization-induced contraction of mechanically skinned slow twitch fibres from rat skeletal muscles.

    PubMed

    Plant, David R; Lynch, Gordon S; Williams, David A

    2002-03-15

    The effect of exogenous hydrogen peroxide (H(2)O(2)) on excitation-contraction (E-C) coupling and sarcoplasmic reticulum (SR) function was compared in mechanically skinned slow twitch fibres (prepared from the soleus muscles) and fast twitch fibres (prepared from the extensor digitorum longus; EDL muscles) of adult rats. Equilibration (5 min) with 1 mM H(2)O(2) diminished the ability of the Ca(2+)-depleted SR to reload Ca(2+) in both slow (P < 0.01) and fast twitch fibres (P < 0.05) compared to control. Under conditions when all Ca(2+) uptake was prevented, 1 mM H(2)O(2) increased SR Ca(2+) "leak" in fast twitch fibres by 24 +/- 5 % (P < 0.05), but leak was not altered in slow twitch fibres. Treatment with 1 mM H(2)O(2) also increased the peak force of low [caffeine] contracture by approximately 45% in both fibre types compared to control (P < 0.01), which could be partly reversed following treatment with 10 mM dithiothreitol (DTT). The changes in SR function caused by 1 mM H(2)O(2) were associated with an approximately 65% increase in the peak height of depolarization-induced contractile response (DICR) in slow twitch fibres, compared to control (no H(2)O(2); P < 0.05). In contrast, peak contractile force of fast twitch fibres was not altered by 1 mM H(2)O(2) treatment. Equilibration with 5 mM H(2)O(2) induced a spontaneous force response in both slow and fast twitch fibres, which could be partly reversed by 2 min treatment with 10 mM DTT. Peak DICR was also increased approximately 40% by 5 mM H(2)O(2) in slow twitch fibres compared to control (no H(2)O(2); P < 0.05). Our results indicate that exogenous H(2)O(2) increases depolarization-induced contraction of mechanically skinned slow but not fast twitch fibres. The increase in depolarization-induced contraction in slow twitch fibres might be mediated by an increased SR Ca(2+) release during contraction and/or an increase in Ca(2+) sensitivity.

  18. Hydrogen peroxide increases depolarization-induced contraction of mechanically skinned slow twitch fibres from rat skeletal muscles

    PubMed Central

    Plant, David R; Lynch, Gordon S; Williams, David A

    2002-01-01

    The effect of exogenous hydrogen peroxide (H2O2) on excitation-contraction (E-C) coupling and sarcoplasmic reticulum (SR) function was compared in mechanically skinned slow twitch fibres (prepared from the soleus muscles) and fast twitch fibres (prepared from the extensor digitorum longus; EDL muscles) of adult rats. Equilibration (5 min) with 1 mm H2O2 diminished the ability of the Ca2+-depleted SR to reload Ca2+ in both slow (P < 0.01) and fast twitch fibres (P < 0.05) compared to control. Under conditions when all Ca2+ uptake was prevented, 1 mm H2O2 increased SR Ca2+ ‘leak’ in fast twitch fibres by 24 ± 5 % (P < 0.05), but leak was not altered in slow twitch fibres. Treatment with 1 mm H2O2 also increased the peak force of low [caffeine] contracture by ∼45 % in both fibre types compared to control (P < 0.01), which could be partly reversed following treatment with 10 mm dithiothreitol (DTT). The changes in SR function caused by 1 mm H2O2 were associated with an ∼65 % increase in the peak height of depolarization-induced contractile response (DICR) in slow twitch fibres, compared to control (no H2O2; P < 0.05). In contrast, peak contractile force of fast twitch fibres was not altered by 1 mm H2O2 treatment. Equilibration with 5 mm H2O2 induced a spontaneous force response in both slow and fast twitch fibres, which could be partly reversed by 2 min treatment with 10 mm DTT. Peak DICR was also increased ∼40 % by 5 mm H2O2 in slow twitch fibres compared to control (no H2O2; P < 0.05). Our results indicate that exogenous H2O2 increases depolarization-induced contraction of mechanically skinned slow but not fast twitch fibres. The increase in depolarization-induced contraction in slow twitch fibres might be mediated by an increased SR Ca2+ release during contraction and/or an increase in Ca2+ sensitivity. PMID:11897857

  19. The purinergic component of human bladder smooth muscle cells’ proliferation and contraction under physiological stretch

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wazir, Romel; Luo, De-Yi; Tian, Ye

    Highlights: •Stretch induces proliferation and contraction. •Optimum applied stretch in vitro is 5% and 10% equibiaxial stretching respectively. •Expression of P2X1 and P2X2 is upregulated after application of stretch. •P2X2 is possibly more susceptible to stretch related changes. •Purinoceptors functioning may explain conditions with atropine resistance. -- Abstract: Objective: To investigate whether cyclic stretch induces proliferation and contraction of human smooth muscle cells (HBSMCs), mediated by P2X purinoceptor 1 and 2 and the signal transduction mechanisms of this process. Methods: HBSMCs were seeded on silicone membrane and stretched under varying parameters; (equibiaxial elongation: 2.5%, 5%, 10%, 15%, 20%, 25%), (Frequency:more » 0.05 Hz, 0.1 Hz, 0.2 Hz, 0.5 Hz, 1 Hz). 5-Bromo-2-deoxyuridine assay was employed for proliferative studies. Contractility of the cells was determined using collagen gel contraction assay. After optimal physiological stretch was established; P2X1 and P2X2 were analyzed by real time polymerase chain reaction and Western Blot. Specificity of purinoceptors was maintained by employing specific inhibitors; (NF023 for P2X1, and A317491for P2X2), in some experiments. Results: Optimum proliferation and contractility were observed at 5% and 10% equibiaxial stretching respectively, applied at a frequency of 0.1 Hz; At 5% stretch, proliferation increased from 0.837 ± 0.026 (control) to 1.462 ± 0.023%, p < 0.05. Mean contraction at 10% stretching increased from 31.7 ± 2.3%, (control) to 78.28 ±1.45%, p < 0.05. Expression of P2X1 and P2X2 was upregulated after application of stretch. Inhibition had effects on proliferation (1.232 ± 0.051, p < 0.05 NF023) and (1.302 ± 0.021, p < 0.05 A314791) while contractility was markedly reduced (68.24 ± 2.31, p < 0.05 NF023) and (73.2 ± 2.87, p < 0.05 A314791). These findings shows that mechanical stretch can promote magnitude-dependent proliferative and contractile modulation of HBSMCs in vitro, and P2X1 and 2 are at least partially responsible in this process.« less

  20. 48 CFR 19.202-2 - Locating small business sources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Locating small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-2 Locating small business sources. The contracting officer must, to the extent practicable, encourage maximum participation by small business...

  1. 48 CFR 19.202-2 - Locating small business sources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Locating small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-2 Locating small business sources. The contracting officer must, to the extent practicable, encourage maximum participation by small business...

  2. 48 CFR 19.202-2 - Locating small business sources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Locating small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-2 Locating small business sources. The contracting officer must, to the extent practicable, encourage maximum participation by small business...

  3. 48 CFR 19.202-2 - Locating small business sources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Locating small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-2 Locating small business sources. The contracting officer must, to the extent practicable, encourage maximum participation by small business...

  4. 48 CFR 19.202-2 - Locating small business sources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Locating small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-2 Locating small business sources. The contracting officer must, to the extent practicable, encourage maximum participation by small business...

  5. Catalyst Bed Instability Within the USFE H2O2/JP-8 Rocket Engine

    NASA Technical Reports Server (NTRS)

    Johnson, Curtis W.; Anderson, William; Ross, Robert; Lyles, G. (Technical Monitor)

    2000-01-01

    Orbital Sciences Corporation has been awarded a contract by NASA's Marshall Space Flight Center, in cooperation with the U.S. Air Force Research Laboratory's Military Space Plane Technology Program Office, for the Upper Stage Flight Experiment (USFE) program. Orbital is designing, developing, and will flight test a new low-cost, 10,000 lbf hydrogen peroxide/ JP-8 pressure fed liquid rocket. During combustion chamber tests at NASA Stennis Space Center (SSC) of the USFE engine, the catalyst bed showed a low frequency instability occurring as the H202 flow reached about 1/3 its design rate. This paper reviews the USFE catalyst bed and combustion chamber and its operation, then discusses the dynamics of the instability. Next the paper describes the dynamic computer model used to recreate the instability. The model was correlated to the SSC test data, and used to investigate possible solutions to the problem. The combustion chamber configuration which solved the instability is shown, and the subsequent stable operation presented.

  6. REACH. Teacher's Guide, Volume I. Post-Secondary Program Management.

    ERIC Educational Resources Information Center

    Morris, James Lee; And Others

    Designed for use with individualized instruction units (CE 026 345-347, and CE 026 349-351) in the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this first volume of the postsecondary teacher's guide is devoted to the establishment of standard instructional procedures. Following an introductory…

  7. Revealing on metallurgical behavior of iron-rich Sm(Co0.65Fe0.26Cu0.07Zr0.02)7.8 sintered magnets

    NASA Astrophysics Data System (ADS)

    Song, Kuikui; Sun, Wei; Chen, Hongsheng; Yu, Nengjun; Fang, Yikun; Zhu, Minggang; Li, Wei

    2017-05-01

    The sintered magnets with the nominal composition of Sm(Co0.65Fe0.26Cu0.07Zr0.02)7.8 were prepared by standard metallurgical method. The evolution of phase transformation of the specimens during heat treatments was investigated in detail. After isothermal aging at 1103 K for 20 hrs and step cooling to 673 K and keeping for 10hrs, the remanence Br of the specimens almost keeps constant (˜11.5 kGs), while the intrinsic coercivity Hcj increases from 7.9 to 31.5 kOe. The maximum energy product of the final magnet is close to 32 MGOe. The phase is single phase with 1:7H structure in the specimen A only annealed at 1453 K for 4hrs. It is found that a cellular microstructure with a platelet Z-phase have appeared in the sample after the isothermal aging in 1103 K for 20h, which contain 2:17R, 2:7R and 5:19H phases. Furthermore, the 1:5H phase has appeared after the step cooling to 873 K, together with some 2:17R, 2:7R and 5:19H phases. Interestingly, it is found that the phase transformation has completed after the step cooling to 773 K. And the phase constitution in specimens is stable during the step cooling to 673 K.

  8. Lake St. Clair: Storm Wave and Water Level Modeling

    DTIC Science & Technology

    2013-06-01

    R. A. Luettich, C. Dawson, V. J. Cardone , A. T. Cox, M. D. Powell, H. J. Westerink, and H. J. Roberts. 2010. A high resolution coupled riverine flow...Storm Wave and Water Level Modeling 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Tyler J. Hesser

  9. Overview of long pulse H-mode operation on EAST

    NASA Astrophysics Data System (ADS)

    Gong, X.; Garofalo, A. M.; Wan, B.; Li, J.; Qian, J.; Li, E.; Liu, F.; Zhao, Y.; Wang, M.; Xu, H.; EAST Team

    2017-10-01

    The EAST research program aims to demonstrate steady-state long-pulse high-performance H-mode operations with ITER-like poloidal configuration and RF-dominated heating schemes. In the recent experimental campaign, a long pulse fully non-inductive H-mode discharge lasting over 100 seconds using the upper ITER-like tungsten divertor has been achieved in EAST. This scenario used only RF heating and current drive, but also benefitted from an integrated control of the wall conditioning, plasma configuration, divertor heat flux, particle exhaust, impurity management and superconducting coils safety. Maintaining effective coupling of multiple RF heating and current drive sources on EAST is a critical ingredient. This long pulse discharge had good energy confinement, H98,y2 1.1-1.2, and all of the plasma parameters reach a true steady-state. Power balance indicates that the confinement improvement is due partly to a significantly reduced core electron transport inside minor radius rho<0.4. This work was supported by the National Magnetic Confinement Fusion Program of China Contract No. 2015GB10200 and the US Department of Energy Contract No. DE-SC0010685.

  10. Daylighting Coefficient of Utilization Tables.

    DTIC Science & Technology

    1983-08-01

    Fiue winte skymnac ( nom un autumn/spring~~ sky (no.~. su)cea ite k (osn 3-7 If ICA 5000 a8.000 .44 Z 4 1000 Si 0 10 20 30 40 50 00 70 80 SOLAR AL...147 257 352 380 387 391 392 482 I I 30 I 012 026 043 054 060 067 070 086 I I 8 50 1 006 013 021 026 029 033 035 043 I I 70 I 005 011 017 021 023 026...045 048 059 I I 70 I 006 013 021 026 028 032 035 043 I I 90 I 005 012 019 023 025 029 031 038 I I 10 1 090 165 244 272 283 290 291 395 1 I 30 I 009

  11. 48 CFR 419.201-71 - Small business coordinators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Small business... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 419.201-71 Small business coordinators. The head of the contracting activity (HCA) or a representative of the HCA shall designate in writing a small business...

  12. Avionics Simulation, Development and Software Engineering

    NASA Technical Reports Server (NTRS)

    Francis, Ronald C.; Settle, Gray; Tobbe, Patrick A.; Kissel, Ralph; Glaese, John; Blanche, Jim; Wallace, L. D.

    2001-01-01

    This monthly report summarizes the work performed under contract NAS8-00114 for Marshall Space Flight Center in the following tasks: 1) Purchase Order No. H-32831D, Task Order 001A, GPB Program Software Oversight; 2) Purchase Order No. H-32832D, Task Order 002, ISS EXPRESS Racks Software Support; 3) Purchase Order No. H-32833D, Task Order 003, SSRMS Math Model Integration; 4) Purchase Order No. H-32834D, Task Order 004, GPB Program Hardware Oversight; 5) Purchase Order No. H-32835D, Task Order 005, Electrodynamic Tether Operations and Control Analysis; 6) Purchase Order No. H-32837D, Task Order 007, SRB Command Receiver/Decoder; and 7) Purchase Order No. H-32838D, Task Order 008, AVGS/DART SW and Simulation Support

  13. 10 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., into which a project is divided for budgeting and funding purposes. Continuation award means an award... project period or renewal thereof. Contract means a written procurement contract executed by a recipient... sharing or matching means that portion of project or programs costs not borne by the Federal Government...

  14. 7 CFR 1430.204 - Requesting benefits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their contract...

  15. 7 CFR 1430.204 - Requesting benefits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their contract...

  16. 7 CFR 1430.204 - Requesting benefits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their contract...

  17. 7 CFR 1430.204 - Requesting benefits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their contract...

  18. 7 CFR 1430.204 - Requesting benefits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their contract...

  19. A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro.

    PubMed

    Battistini, B; Filep, J G; Cragoe, E J; Fournier, A; Sirois, P

    1991-03-15

    Endothelin-1-induced contractions of guinea pig tracheal and bronchial strips were dose-dependently attenuated by the amiloride analogues 5-(N-ethyl-N-isopropyl)amiloride (EIPA, 1-10 microM) and 5-(N,N-hexamethylene)amiloride (HMA, 1-10 microM). The calculated Ki values for EIPA and HMA were 0.11 +/- 0.02 microM and 0.06 +/- 0.02 microM in the trachea, and 0.28 +/- 0.11 microM and 0.70 +/- 0.25 microM in the bronchus, respectively. These values are in the same order of magnitude as those reported for inhibition of the Na+/H+ exchange in cells. Amiloride (1-10 microM) was ineffective. These data suggest that activation of the Na+/H+ exchange by ET-1 may be involved in mediating its myotropic action in guinea pig airway smooth muscle.

  20. Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction

    PubMed Central

    Lang, Charles H.

    2014-01-01

    Alcohol (EtOH) decreases protein synthesis and mammalian target of rapamycin (mTOR)-mediated signaling and blunts the anabolic response to growth factors in skeletal muscle. The purpose of the current investigation was to determine whether acute EtOH intoxication antagonizes the contraction-induced increase in protein synthesis and mTOR signaling in skeletal muscle. Fasted male mice were injected intraperitoneally with 3 g/kg EtOH or saline (control), and the right hindlimb was electrically stimulated (10 sets of 6 contractions). The gastrocnemius muscle complex was collected 30 min, 4 h, or 12 h after stimulation. EtOH decreased in vivo basal protein synthesis (PS) in the nonstimulated muscle compared with time-matched Controls at 30 min, 4 h, and 12 h. In Control, but not EtOH, PS was decreased 15% after 30 min. In contrast, PS was increased in Control 4 h poststimulation but remained unchanged in EtOH. Last, stimulation increased PS 10% in Control and EtOH at 12 h, even though the absolute rate remained reduced by EtOH. The stimulation-induced increase in the phosphorylation of S6K1 Thr421/Ser424 (20–52%), S6K1 Thr389 (45–57%), and its substrate rpS6 Ser240/244 (37–72%) was blunted by EtOH at 30 min, 4 h, and 12 h. Phosphorylation of 4E-BP1 Ser65 was also attenuated by EtOH (61%) at 4 h. Conversely, phosphorylation of extracellular signal-regulated kinase Thr202/Tyr204 was increased by stimulation in Control and EtOH mice at 30 min but only in Control at 4 h. Our data indicate that acute EtOH intoxication suppresses muscle protein synthesis for at least 12 h and greatly impairs contraction-induced changes in synthesis and mTOR signaling. PMID:25257868

  1. Testing of small and large sign support systems FOIL test number : 92F026

    DOT National Transportation Integrated Search

    1994-07-01

    This test report contains the results of a crash test performed at the Federal Outdoor Impact Laboratory (FOIL) in McLean, Virginia. The test was performed on a small sign support system at 20 mi/h (8.9 m/s), test 92F026. The vehicle used for this te...

  2. Studies of the mechanism of passive anaphylaxis in human airway smooth muscle.

    PubMed

    Davis, C; Jones, T R; Daniel, E E

    1983-07-01

    This investigation was carried out to study allergic contraction of passively sensitized human airway smooth muscle in response to specific antigen challenge. We attempted to determine the role played by histamine, slow reaction substances (SRSs), and cyclooxygenase products in the mediation of this response in tracheal smooth muscle. Tissues were passively sensitized with serum from ragweed-sensitive patients (15 h, 4 degrees C). Subsequent challenge with ragweed antigen produced a slowly developing contraction. The peak contraction to a dose producing a maximal response was 37 +/- 6% of the carbachol maximum. Mepyramine (5 X 10(-6) M) did not alter the contraction. Methylprednisolone (2 X 10(-5) M) attenuated the response to antigen but had no significant effect on the contractile response to arachidonic acid. Indomethacin (5.6-28 X 10(-6) M) enhanced the peak antigen-induced contractions by 25 +/- 11% whereas 5,8,11,14-eicosatetraynoic acid (6.4 X 10(-5) M) selectively attenuated the antigen-induced contraction by 86 +/- 12%. Nordihydroguarietic acid (6-12 X 10(-6) M) attenuated both the antigen plus arachidonate induced responses. FPL-55712 (1-2 X 10(-6) M) antagonized the contractions to antigen. Compound 48/80 and goat antihuman immunoglobulin E produced similar slowly developing contractions in sensitized and in some nonsensitized tissues. These responses, except for an early component of the response to 48/80, were independent of histamine and were reversed by FPL-55712. These findings suggest that arachidonic acid metabolites mediate (slow reacting substances) and modulate (prostaglandins) allergic contraction of human airway smooth muscle while any histamine released contributes little or nothing to the contraction in the larger airways.

  3. 48 CFR 252.209-7009 - Organizational Conflict of Interest-Major Defense Acquisition Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Organizational Conflict of... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.209-7009 Organizational... clause: ORGANIZATIONAL CONFLICT OF INTEREST—MAJOR DEFENSE ACQUISITION PROGRAM (DEC 2010) (a) Definition...

  4. 48 CFR 1852.246-70 - Mission Critical Space System Personnel Reliability Program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Mission Critical Space... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.246-70 Mission Critical Space System Personnel Reliability Program. As prescribed in 1846.370(a), insert the following clause: Mission Critical Space System...

  5. 48 CFR 1852.246-70 - Mission Critical Space System Personnel Reliability Program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Mission Critical Space... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.246-70 Mission Critical Space System Personnel Reliability Program. As prescribed in 1846.370(a), insert the following clause: Mission Critical Space System...

  6. 48 CFR 1852.246-70 - Mission Critical Space System Personnel Reliability Program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Mission Critical Space... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.246-70 Mission Critical Space System Personnel Reliability Program. As prescribed in 1846.370(a), insert the following clause: Mission Critical Space System...

  7. 48 CFR 1852.246-70 - Mission Critical Space System Personnel Reliability Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mission Critical Space... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.246-70 Mission Critical Space System Personnel Reliability Program. As prescribed in 1846.370(a), insert the following clause: Mission Critical Space System...

  8. 48 CFR 1852.246-70 - Mission Critical Space System Personnel Reliability Program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Mission Critical Space... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.246-70 Mission Critical Space System Personnel Reliability Program. As prescribed in 1846.370(a), insert the following clause: Mission Critical Space System...

  9. 48 CFR 26.202-1 - Local area set-aside.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Local area set-aside. 26... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Disaster or Emergency Assistance Activities 26.202-1 Local area set-aside. The contracting officer may set aside solicitations to allow only local firms within a...

  10. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a), use the following clause: Balance of Payments Program...

  11. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a)(1), use the following clause: Balance of Payments Program...

  12. 42 CFR 438.240 - Quality assessment and performance improvement program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Quality assessment and performance improvement... Performance Improvement Measurement and Improvement Standards § 438.240 Quality assessment and performance improvement program. (a) General rules. (1) The State must require, through its contracts, that each MCO and...

  13. 48 CFR 252.219-7004 - Small business subcontracting plan (test program).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Small business... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.219-7004 Small business subcontracting plan (test program). As prescribed in 219.708(b)(1)(B), use the following clause: Small Business...

  14. 48 CFR 252.219-7004 - Small business subcontracting plan (test program).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Small business... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.219-7004 Small business subcontracting plan (test program). As prescribed in 219.708(b)(1)(B), use the following clause: Small Business...

  15. Evaluation of the fetal state by automatic analysis of the heart rate. 2. Deceleration areas and umbilical artery blood pH.

    PubMed

    Tournaire, M; Sturbois, G; Ripoche, A; Le Houezec, R; Breart, G; Chavinie, J; Sureau, C

    1976-01-01

    Fetal heart rate (FHR) deceleration areas were studied to obtain by objective measurement of the FHR, their prognostic value of the new-born state. 1. There is a reasonably good correlation between FHR deceleration areas and UApH (Tab. II). Such a correlation was found by SHELLEY and TIPTON [6] for the whole deceleration area, and by TOURNAIRE et al. [10] for areas divided in a slightly different way. The correlation coefficients between FHR deceleration areas and Apgar score at 1 minute are within a close range of those of the FHR deceleration area and UApH (Tab. I and II). 2. According to the time relationship between deceleration areas and uterine contractions the best correlation coefficient was obtained surprisingly for total, followed by residual and then simultaneous areas. These results agree with those of SHELLEY and TIPTON [6] suggesting that in practice a simple measurement of the whole deceleration area, regardless of the uterine contractions is a sufficient method in evaluating FHR patterns. 3. The special purpose computer built by the BAUDELOCQUE research group can be used on-line, thus in clinical practice. It was not the case for the manual method [4] or the method using a large programmed computer [10]. 4 The evaluation of deceleration areas appears to have several advantages: 1. It provides objective measurements. 2. The unit used is independant of factors such as display speed or scale of the strip-chart. 3. The data is reduced: A few numbers replace the long descriptions of the usual clinical classifications.

  16. Automated evaluation of matrix elements between contracted wavefunctions: A Mathematica version of the FRODO program

    NASA Astrophysics Data System (ADS)

    Angeli, C.; Cimiraglia, R.

    2013-02-01

    A symbolic program performing the Formal Reduction of Density Operators (FRODO), formerly developed in the MuPAD computer algebra system with the purpose of evaluating the matrix elements of the electronic Hamiltonian between internally contracted functions in a complete active space (CAS) scheme, has been rewritten in Mathematica. New version : A program summaryProgram title: FRODO Catalogue identifier: ADV Y _v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADVY_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3878 No. of bytes in distributed program, including test data, etc.: 170729 Distribution format: tar.gz Programming language: Mathematica Computer: Any computer on which the Mathematica computer algebra system can be installed Operating system: Linux Classification: 5 Catalogue identifier of previous version: ADV Y _v1_0 Journal reference of previous version: Comput. Phys. Comm. 171(2005)63 Does the new version supersede the previous version?: No Nature of problem. In order to improve on the CAS-SCF wavefunction one can resort to multireference perturbation theory or configuration interaction based on internally contracted functions (ICFs) which are obtained by application of the excitation operators to the reference CAS-SCF wavefunction. The previous formulation of such matrix elements in the MuPAD computer algebra system, has been rewritten using Mathematica. Solution method: The method adopted consists in successively eliminating all occurrences of inactive orbital indices (core and virtual) from the products of excitation operators which appear in the definition of the ICFs and in the electronic Hamiltonian expressed in the second quantization formalism. Reasons for new version: Some years ago we published in this journal a couple of papers [1, 2] hereafter to be referred to as papers I and II, respectively dedicated to the automated evaluation of the matrix elements of the molecular electronic Hamiltonian between internally contracted functions [3] (ICFs). In paper II the program FRODO (after Formal Reduction Of Density Operators) was presented with the purpose of providing working formulas for each occurrence of the ICFs. The original FRODO program was written in the MuPAD computer algebra system [4] and was actively used in our group for the generation of the matrix elements to be employed in the third-order n-electron valence state perturbation theory (NEVPT) [5-8] as well as in the internally contracted configuration interaction (IC-CI) [9]. We present a new version of the program FRODO written in the Mathematica system [10]. The reason for the rewriting of the program lies in the fact that, on the one hand, MuPAD does not seem to be any longer available as a stand-alone system and, on the other hand, Mathematica, due to its ubiquitousness, appears to be increasingly the computer algebra system most widely used nowadays. Restrictions: The program is limited to no more than doubly excited ICFs. Running time: The examples described in the Readme file take a few seconds to run. References: [1] C. Angeli, R. Cimiraglia, Comp. Phys. Comm. 166 (2005) 53. [2] C. Angeli, R. Cimiraglia, Comp. Phys. Comm. 171 (2005) 63. [3] H.-J. Werner, P. J. Knowles, Adv. Chem. Phys. 89 (1988) 5803. [4] B. Fuchssteiner, W. Oevel: http://www.mupad.de Mupad research group, university of Paderborn. Mupad version 2.5.3 for Linux. [5] C. Angeli, R. Cimiraglia, S. Evangelisti, T. Leininger, J.-P. Malrieu, J. Chem. Phys. 114 (2001) 10252. [6] C. Angeli, R. Cimiraglia, J.-P. Malrieu, J. Chem. Phys. 117 (2002) 9138. [7] C. Angeli, B. Bories, A. Cavallini, R. Cimiraglia, J. Chem. Phys. 124 (2006) 054108. [8] C. Angeli, M. Pastore, R. Cimiraglia, Theor. Chem. Acc. 117 (2007) 743. [9] C. Angeli, R. Cimiraglia, Mol. Phys. in press, DOI:10.1080/00268976.2012.689872 [10] http://www.wolfram.com/Mathematica. Mathematica version 8 for Linux.

  17. Carbon Nanotube Based Flexible Supercapacitors

    DTIC Science & Technology

    2011-04-01

    Carbon Nanotube Based Flexible Supercapacitors by Christopher M. Anton and Matthew H. Ervin ARL-TR-5522 April 2011...Carbon Nanotube Based Flexible Supercapacitors Christopher M. Anton and Matthew H. Ervin Sensors and Electron Devices Directorate, ARL...September 2010 4. TITLE AND SUBTITLE Carbon Nanotube Based Flexible Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

  18. A Comparison of Electrolytic Capacitors and Supercapacitors for Piezo-Based Energy Harvesting

    DTIC Science & Technology

    2013-07-01

    A Comparison of Electrolytic Capacitors and Supercapacitors for Piezo-Based Energy Harvesting by Matthew H. Ervin, Carlos M. Pereira, John R...Capacitors and Supercapacitors for Piezo-Based Energy Harvesting Matthew H. Ervin Sensors and Electronic Devices Directorate, ARL Carlos M. Pereira... Supercapacitors for Piezo-Based Energy Harvesting 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Matthew H

  19. 10 CFR 455.101 - Borrowing the non-Federal share/title to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....101 Section 455.101 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND... borrowed funds, such as those provided by loans and performance contracts, even if such financing does not... financing and loan agreements and performance contracts under this section are subject to the requirements...

  20. 7 CFR 636.10 - Modifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Modifications. 636.10 Section 636.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636.10 Modifications. (a) The...

  1. 7 CFR 636.10 - Modifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Modifications. 636.10 Section 636.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVES PROGRAM § 636.10 Modifications. (a) The...

  2. 7 CFR 636.10 - Modifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Modifications. 636.10 Section 636.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636.10 Modifications. (a) The...

  3. 7 CFR 636.10 - Modifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Modifications. 636.10 Section 636.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636.10 Modifications. (a) The...

  4. 7 CFR 636.10 - Modifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Modifications. 636.10 Section 636.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636.10 Modifications. (a) The...

  5. Fermi-LAT Constraints on the Pulsar Wind Nebula Nature of HESS J1857+026

    NASA Technical Reports Server (NTRS)

    Rousseau, R.; Grondin, M.-H.; VanEtten, A.; Lemoine-Goumard, M.; Bogdanov, S.; Hessels, J. W. T.; Kaspi, V. M.; Arzoumanian, Z.; Camilo, F.; Casandjian, J. M.; hide

    2012-01-01

    Since its launch, the Fermi satellite has firmly identified 5 pulsar wind nebulae plus a large number of candidates, all powered by young and energetic pulsars. HESS J1857+026 is a spatially extended gamma-ray source detected by H.E.S.S. and classified as a possible pulsar wind nebula candidate powered by PSR J1856+0245. Aims. We search for -ray pulsations from PSR J1856+0245 and explore the characteristics of its associated pulsar wind nebula. Methods. Using a rotational ephemeris obtained from the Lovell telescope at Jodrell Bank Observatory at 1.5 GHz, we phase.fold 36 months of gamma-ray data acquired by the Large Area Telescope (LAT) aboard Fermi. We also perform a complete gamma-ray spectral and morphological analysis. Results. No pulsation was detected from PSR J1856+0245. However, significant emission is detected at a position coincident with the TeV source HESS J1857+026. The gamma-ray spectrum is well described by a simple power law with a spectral index of Gamma = 1.53 +/- 0.11(sub stat) +/- 0.55(sub syst) and an energy flux of G(0.1 C100 GeV) = (2.71 +/- 0.52(sub stat) +/- 1.51(sub syst) X 10(exp -11) ergs/ sq cm/s. This implies a gamma.ray efficiency of approx 5 %, assuming a distance of 9 kpc, the gamma-ray luminosity of L(sub gamma) (sub PWN) (0.1 C100 GeV) = (2.5 +/- 0.5(sub stat) +/- 1.5(sub syst)) X 10(exp 35)(d/(9kpc))(exp 2) ergs/s and E-dot = 4.6 X 10(exp 36) erg /s, in the range expected for pulsar wind nebulae. Detailed multi-wavelength modeling provides new constraints on its pulsar wind nebula nature.

  6. 10 CFR 784.6 - National security considerations for waiver of certain sensitive inventions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... or under any Government contract or subcontract of the Naval Nuclear Propulsion Program or the nuclear weapons programs or other atomic energy defense activities of the Department of Energy, a...) under the Naval Nuclear Propulsion Program or the nuclear weapons programs or other atomic energy...

  7. 10 CFR 784.6 - National security considerations for waiver of certain sensitive inventions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or under any Government contract or subcontract of the Naval Nuclear Propulsion Program or the nuclear weapons programs or other atomic energy defense activities of the Department of Energy, a...) under the Naval Nuclear Propulsion Program or the nuclear weapons programs or other atomic energy...

  8. The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery

    PubMed Central

    Ihara, Eikichi; Hirano, Katsuya; Derkach, Dmitry N; Nishimura, Junji; Nawata, Hajime; Kanaide, Hideo

    2000-01-01

    The mechanism of endothelium-dependent regulation of vascular tone of bradykinin was investigated by simultaneously monitoring the changes in the cytosolic Ca2+ concentration and the force of smooth muscle in fura-2-loaded strips of the porcine renal artery with endothelium. During phenylephrine-induced sustained contraction, bradykinin (>3×10−9 M) caused endothelium-dependent triphasic changes in the force of the strips, composed of an initial relaxation, a subsequent transient contraction and a late sustained relaxation. At low concentrations (10−10–10−9 M), bradykinin caused an endothelium-dependent biphasic relaxation with no contraction. A thromboxane A2 (TXA2)/prostaglandin H2 (PGH2) receptor antagonist (10−5 M ONO-3708) completely inhibited, while a TXA2 synthase inhibitor (10−5 M OKY-046) only partially inhibited, the transient contraction induced by bradykinin. Under conditions where the bradykinin-induced contraction was inhibited by ONO-3708 during the phenylephrine-induced contraction, bradykinin induced only a transient relaxation in the presence of NΩ-nitro-L-arginine methyl ester (L-NAME). This transient relaxation was inhibited when the precontraction was initiated by phenylephrine plus 40 mM extracellular K+. The removal of L-NAME from this condition caused a partial reappearance of the initial relaxation and a complete reappearance of the sustained relaxation. In conclusion, bradykinin caused the endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery. The concentrations of bradykinin required to induce a contraction was higher than that required to induce relaxation. Both TXA2 and PGH2 were involved in the bradykinin-induced contraction. The initial relaxation was mediated by nitric oxide and hyperpolarizing factors while the sustained relaxation depended on nitric oxide. PMID:10696094

  9. 48 CFR 45.303 - Use of Government property on independent research and development programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Authorizing the Use... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Use of Government property... research and development (IR&D) program, if— (a) Such use will not conflict with the primary use of the...

  10. 48 CFR 45.303 - Use of Government property on independent research and development programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Authorizing the Use... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Use of Government property... research and development (IR&D) program, if— (a) Such use will not conflict with the primary use of the...

  11. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Quality of life of participants. (4) Effectiveness and safety of staff-provided and contracted services... 42 Public Health 4 2012-10-01 2012-10-01 false Minimum requirements for quality assessment and... ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Quality Assessment and Performance...

  12. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Quality of life of participants. (4) Effectiveness and safety of staff-provided and contracted services... 42 Public Health 4 2011-10-01 2011-10-01 false Minimum requirements for quality assessment and... ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Quality Assessment and Performance...

  13. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Quality of life of participants. (4) Effectiveness and safety of staff-provided and contracted services... 42 Public Health 4 2010-10-01 2010-10-01 false Minimum requirements for quality assessment and... ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Quality Assessment and Performance...

  14. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Quality of life of participants. (4) Effectiveness and safety of staff-provided and contracted services... 42 Public Health 4 2013-10-01 2013-10-01 false Minimum requirements for quality assessment and... ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Quality Assessment and Performance...

  15. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Quality of life of participants. (4) Effectiveness and safety of staff-provided and contracted services... 42 Public Health 4 2014-10-01 2014-10-01 false Minimum requirements for quality assessment and... ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Quality Assessment and Performance...

  16. 49 CFR 26.25 - What is the requirement for a liaison officer?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is the requirement for a liaison officer? 26... Requirements for DBE Programs for Federally-Assisted Contracting § 26.25 What is the requirement for a liaison... Executive Officer concerning DBE program matters. The liaison officer shall be responsible for implementing...

  17. 49 CFR 26.25 - What is the requirement for a liaison officer?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What is the requirement for a liaison officer? 26... Requirements for DBE Programs for Federally-Assisted Contracting § 26.25 What is the requirement for a liaison... Executive Officer concerning DBE program matters. The liaison officer shall be responsible for implementing...

  18. 48 CFR 252.225-7000 - Buy American Act-Balance of Payments Program Certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Buy American Act-Balance... PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7000 Buy American Act—Balance of... Act—Balance of Payments Program Certificate (DEC 2009) (a) Definitions. “Commercially available off...

  19. 49 CFR 26.37 - What are a recipient's responsibilities for monitoring the performance of other program...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What are a recipient's responsibilities for... Contracting § 26.37 What are a recipient's responsibilities for monitoring the performance of other program participants? (a) You must implement appropriate mechanisms to ensure compliance with the part's requirements...

  20. 49 CFR 26.37 - What are a recipient's responsibilities for monitoring the performance of other program...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false What are a recipient's responsibilities for... Contracting § 26.37 What are a recipient's responsibilities for monitoring the performance of other program participants? (a) You must implement appropriate mechanisms to ensure compliance with the part's requirements...

  1. 49 CFR 26.37 - What are a recipient's responsibilities for monitoring the performance of other program...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false What are a recipient's responsibilities for... Contracting § 26.37 What are a recipient's responsibilities for monitoring the performance of other program participants? (a) You must implement appropriate mechanisms to ensure compliance with the part's requirements...

  2. 49 CFR 26.37 - What are a recipient's responsibilities for monitoring the performance of other program...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false What are a recipient's responsibilities for... Contracting § 26.37 What are a recipient's responsibilities for monitoring the performance of other program participants? (a) You must implement appropriate mechanisms to ensure compliance with the part's requirements...

  3. 48 CFR 19.502-2 - Total small business set-asides.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Total small business set... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502-2 Total small business set... exclusively for small business concerns and shall be set aside for small business unless the contracting...

  4. 48 CFR 19.502-2 - Total small business set-asides.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Total small business set... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502-2 Total small business set... contracting officer does not proceed with the small business set-aside and purchases on an unrestricted basis...

  5. 48 CFR 19.502-2 - Total small business set-asides.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Total small business set... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502-2 Total small business set... contracting officer does not proceed with the small business set-aside and purchases on an unrestricted basis...

  6. 48 CFR 19.502-2 - Total small business set-asides.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Total small business set... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.502-2 Total small business set... contracting officer does not proceed with the small business set-aside and purchases on an unrestricted basis...

  7. 48 CFR 3052.219-71 - DHS mentor-protégé program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false DHS mentor-protégÃ... CONTRACT CLAUSES Text of Provisions and Clauses 3052.219-71 DHS mentor-protégé program. As prescribed in (HSAR) 48 CFR 3019.708-70(b), insert the following clause: DHS Mentor-Protégé Program (JUN 2006) (a...

  8. Diaphragmatic lymphatic vessel behavior during local skeletal muscle contraction.

    PubMed

    Moriondo, Andrea; Solari, Eleonora; Marcozzi, Cristiana; Negrini, Daniela

    2015-02-01

    The mechanism through which the stresses developed in the diaphragmatic tissue during skeletal muscle contraction sustain local lymphatic function was studied in 10 deeply anesthetized, tracheotomized adult Wistar rats whose diaphragm was exposed after thoracotomy. To evaluate the direct effect of skeletal muscle contraction on the hydraulic intraluminal lymphatic pressures (Plymph) and lymphatic vessel geometry, the maximal contraction of diaphragmatic fibers adjacent to a lymphatic vessel was elicited by injection of 9.2 nl of 1 M KCl solution among diaphragmatic fibers while Plymph was recorded through micropuncture and vessel geometry via stereomicroscopy video recording. In lymphatics oriented perpendicularly to the longitudinal axis of muscle fibers and located at <300 μm from KCl injection, vessel diameter at maximal skeletal muscle contraction (Dmc) decreased to 61.3 ± 1.4% of the precontraction value [resting diameter (Drest)]; however, if injection was at >900 μm from the vessel, Dmc enlarged to 131.1 ± 2.3% of Drest. In vessels parallel to muscle fibers, Dmc increased to 122.8 ± 2.9% of Drest. During contraction, Plymph decreased as much as 22.5 ± 2.6 cmH2O in all submesothelial superficial vessels, whereas it increased by 10.7 ± 5.1 cmH2O in deeper vessels running perpendicular to contracting muscle fibers. Hence, the three-dimensional arrangement of the diaphragmatic lymphatic network seems to be finalized to efficiently exploit the stresses exerted by muscle fibers during the contracting inspiratory phase to promote lymph formation in superficial submesothelial lymphatics and its further propulsion in deeper intramuscular vessels. Copyright © 2015 the American Physiological Society.

  9. Lanthanide contraction effect on crystal structures of lanthanide coordination polymers with cyclohexanocucurbit[6]uril ligand

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zheng, Li-Mei; Liu, Jing-Xin, E-mail: jxliu411@ahut.edu.cn

    A series of compounds based on the macrocyclic ligand cyclohexanocucurbit[6]uril (Cy6Q[6]) with formulas (Ln(H{sub 2}O){sub 6}Cy6Q[6])·2(CdCl{sub 4})·H{sub 3}O·xH{sub 2}O [isomorphous with Ln=La (1), Ce (2), Pr (3) and Nd (4), x=11 (1), 11 (2), 10 (3) and 11 (4)], (Sm(H{sub 2}O){sub 5}Cy6Q[6])·2(CdCl{sub 4})·H{sub 3}O·10H{sub 2}O (5) and (Ln(H{sub 2}O){sub 5}(NO{sub 3})@Cy6Q[6])·2(CdCl{sub 4})·2H{sub 3}O·xH{sub 2}O [isomorphous with Ln=Gd (6), Tb (7) and Dy (8), x=8 (6), 6 (7) and 6 (8)], have been successfully synthesized by the self-assembly of Cy6Q[6] with the corresponding lanthanide nitrate under hydrochloric acid aqueous solution in the presence of CdCl{sub 2}. Single-crystal X-ray diffraction analyses revealedmore » that compounds 1–8 all crystallize in monoclinic space group P2{sub 1}/c, and display 1D coordination polymer structures. The lanthanide contraction effect on the structures of 1–8 has also been investigated and discussed in detail. In contrast, the reaction of Cy6Q[6] with the Ho(NO){sub 3}, Tm(NO){sub 3}, Yb(NO){sub 3} under the same conditions resulted in the compounds 9–11 with formulas Cy6Q[6]·2(CdCl{sub 4})·2H{sub 3}O·xH{sub 2}O [isomorphous with x=10 (9), 10 (10), and 9 (11)], in which no lanthanide cations are observed. The structural difference of these compounds indicates that the Cy6Q[6] may be used in the separation of lanthanide cations. - Graphical abstract: The reaction of cyclohexanocucurbit[6]uril with lanthanide ions (La{sup 3+}, Ce{sup 3+}, Pr{sup 3+}, Nd{sup 3+}, Sm{sup 3+}, Gd{sup 3+}, Tb{sup 3+}, Dy{sup 3+}, Ho{sup 3+}, Tm{sup 3+} and Yb{sup 3+}) under hydrochloric acid in the presence of CdCl{sub 2} resulted in eleven compounds, which demonstrate interesting lanthanide contraction effect and provide a means of separating lanthanide ions. - Highlights: • Eleven compounds of the Ln{sup 3+} with the Cy6Q[6] were synthesized and described. • Compounds 1-8 demonstrate interesting lanthanide contraction effect. • In solid-state structures of compounds 9-11, no lanthanide ions were observed. • This study provides a means of separating lanthanides cations.« less

  10. The impact of meal timing on performance, sleepiness, gastric upset, and hunger during simulated night shift.

    PubMed

    Grant, Crystal Leigh; Dorrian, Jillian; Coates, Alison Maree; Pajcin, Maja; Kennaway, David John; Wittert, Gary Allen; Heilbronn, Leonie Kaye; Vedova, Chris Della; Gupta, Charlotte Cecilia; Banks, Siobhan

    2017-10-07

    This study examined the impact of eating during simulated night shift on performance and subjective complaints. Subjects were randomized to eating at night (n=5; 23.2 ± 5.5 y) or not eating at night (n=5; 26.2 ± 6.4 y). All participants were given one sleep opportunity of 8 h (22:00 h-06:00 h) before transitioning to the night shift protocol. During the four days of simulated night shift participants were awake from 16:00 h-10:00 h with a daytime sleep of 6 h (10:00 h-16:00 h). In the simulated night shift protocol, meals were provided at ≈0700 h, 1900 h and 0130 h (eating at night); or ≈0700 h, 0930 h, 1410 h and 1900 h (not eating at night). Subjects completed sleepiness, hunger and gastric complaint scales, a Digit Symbol Substitution Task and a 10-min Psychomotor Vigilance Task. Increased sleepiness and performance impairment was evident in both conditions at 0400 h (p<0.05). Performance impairment at 0400 h was exacerbated when eating at night. Not eating at night was associated with elevated hunger and a small but significant elevation in stomach upset across the night (p<0.026). Eating at night was associated with elevated bloating on night one, which decreased across the protocol. Restricting food intake may limit performance impairments at night. Dietary recommendations to improve night-shift performance must also consider worker comfort.

  11. The impact of meal timing on performance, sleepiness, gastric upset, and hunger during simulated night shift

    PubMed Central

    GRANT, Crystal Leigh; DORRIAN, Jillian; COATES, Alison Maree; PAJCIN, Maja; KENNAWAY, David John; WITTERT, Gary Allen; HEILBRONN, Leonie Kaye; DELLA VEDOVA, Chris; GUPTA, Charlotte Cecilia; BANKS, Siobhan

    2017-01-01

    This study examined the impact of eating during simulated night shift on performance and subjective complaints. Subjects were randomized to eating at night (n=5; 23.2 ± 5.5 y) or not eating at night (n=5; 26.2 ± 6.4 y). All participants were given one sleep opportunity of 8 h (22:00 h-06:00 h) before transitioning to the night shift protocol. During the four days of simulated night shift participants were awake from 16:00 h-10:00 h with a daytime sleep of 6 h (10:00 h-16:00 h). In the simulated night shift protocol, meals were provided at ≈0700 h, 1900 h and 0130 h (eating at night); or ≈0700 h, 0930 h, 1410 h and 1900 h (not eating at night). Subjects completed sleepiness, hunger and gastric complaint scales, a Digit Symbol Substitution Task and a 10-min Psychomotor Vigilance Task. Increased sleepiness and performance impairment was evident in both conditions at 0400 h (p<0.05). Performance impairment at 0400 h was exacerbated when eating at night. Not eating at night was associated with elevated hunger and a small but significant elevation in stomach upset across the night (p<0.026). Eating at night was associated with elevated bloating on night one, which decreased across the protocol. Restricting food intake may limit performance impairments at night. Dietary recommendations to improve night-shift performance must also consider worker comfort. PMID:28740034

  12. 7 CFR 634.10 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Applicability. 634.10 Section 634.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.10...

  13. 7 CFR 634.10 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Applicability. 634.10 Section 634.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.10...

  14. 7 CFR 634.10 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Applicability. 634.10 Section 634.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.10...

  15. 7 CFR 634.10 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Applicability. 634.10 Section 634.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.10...

  16. 7 CFR 634.10 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Applicability. 634.10 Section 634.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.10...

  17. Probabilistic Sensitivity Analysis with Respect to Bounds of Truncated Distributions (PREPRINT)

    DTIC Science & Technology

    2010-04-01

    AFRL-RX-WP-TP-2010-4147 PROBABILISTIC SENSITIVITY ANALYSIS WITH RESPECT TO BOUNDS OF TRUNCATED DISTRIBUTIONS (PREPRINT) H. Millwater and...5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62102F 6. AUTHOR(S) H. Millwater and Y. Feng 5d. PROJECT...Z39-18 1 Probabilistic Sensitivity Analysis with respect to Bounds of Truncated Distributions H. Millwater and Y. Feng Department of Mechanical

  18. Cisapride stimulates contraction of idiopathic megacolonic smooth muscle in cats.

    PubMed

    Hasler, A H; Washabau, R J

    1997-01-01

    We have previously shown that cisapride, a substituted piperidinyl benzamide, stimulates contraction of healthy feline colonic smooth muscle. The purpose of the present investigation was to determine the effect of cisapride on feline idiopathic megacolonic smooth muscle function. Longitudinal smooth muscle strips from ascending and descending colon were obtained from cats with idiopathic megacolon, suspended in a 1.5 mM Ca(2+)-HEPES buffer solution (37 degrees C, 100% O2, pH 7.4), attached to isometric force transducers, and stretched to optimal muscle length (Lo). Control responses were obtained at each muscle site with acetylcholine (10(-8) to 10(-4) M), substance P (10(-11) to 10(-7) M), or potassium chloride (10 to 80 mM). Muscles were then stimulated with cumulative (10(-9) to 10(-6) M) doses of cisapride in the absence or presence of tetrodotoxin (10(-6) M) and atropine (10(-6) M), or in a 0 calcium HEPES buffer solution. In cats with idiopathic megacolon, cisapride stimulated contractions of longitudinal smooth muscle from both the ascending and the descending colon. Cisapride-induced contractions were similar in magnitude to those induced by substance P and acetylcholine in the ascending colon, but were less than those observed in the descending colon. Cisapride-induced contractions in megacolonic smooth muscle were only partially inhibited by tetrodotoxin and atropine, but were virtually abolished by removal of extracellular calcium. We concluded that cisapride-induced contractions of feline megacolonic smooth muscle are largely smooth muscle mediated and dependent on influx of extracellular calcium. Cisapride-induced contractions in megacolonic smooth muscle are only partially dependent on enteric cholinergic nerves. Thus, cisapride may be useful in the treatment of cats with idiopathic megacolon.

  19. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  20. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  1. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  2. NASA Northeast Regional Technology Transfer Center

    NASA Technical Reports Server (NTRS)

    Dunn, James P.

    2001-01-01

    This report is a summary of the primary activities and metrics for the NASA Northeast Regional Technology Transfer Center, operated by the Center for Technology Commercialization, Inc. (CTC). This report covers the contract period January 1, 2000 - March 31, 2001. This report includes a summary of the overall CTC Metrics, a summary of the Major Outreach Events, an overview of the NASA Business Outreach Program, a summary of the Activities and Results of the Technology into the Zone program, and a Summary of the Major Activities and Initiatives performed by CTC in supporting this contract. Between January 1, 2000 and March 31, 2001, CTC has facilitated 10 license agreements, established 35 partnerships, provided assistance 517 times to companies, and performed 593 outreach activities including participation in 57 outreach events. CTC also assisted Goddard in executing a successful 'Technology into the Zone' program.' CTC is pleased to have performed this contract, and looks forward to continue providing their specialized services in support of the new 5 year RTTC Contract for the Northeast region.

  3. Superconductivity in Ternary Rare-Earth Transition Metal Silicides and Germanides with the SCANDIUM(5) COBALT(4) SILICON(10)-TYPE Structure.

    NASA Astrophysics Data System (ADS)

    Berg, Linda Sue

    A systematic study of the superconducting and normal state properties of some ternary rare earth transition metal silicides and germanides of the Sc(,5)Co(,4)Si(,10) -type is reported in this work. Low temperature heat capacity measurements indicate the presence of a complicated phonon density of states in these structurally complex compounds. A better description of the phonon spectrum of the high T(,c) materials, Sc(,5)Rh(,4)Si(,10), Sc(,5)Ir(,4)Si(,10), and Y(,5)Os(,4)Ge(,10), given by a model proposed by Junod et al.('1), is presented and discussed. The large values of (DELTA)C/(gamma)(,n)T(,c) and the electron-phonon coupling constant for these high T(,c) compounds indicate that they are strong-coupled superconductors. Relative to other ternary superconductors, many of these materials have large Debye temperatures. The BSC theory does not seem to afford an adequate description of the supercon- ducting state in these compounds. DC electrical resistivity measurements on these compounds show resistivity behaviors deviating from those exhibited by simple metals. The (rho)(T) data for Y(,5)Ir(,4)Si(,10), Lu(,5)Rh(,4)Si(,10), Lu(,5)Ir(,4)Si(,10), and Y(,5)Os(,4)Ge(,10), indicate the presence of anomalies. Static molar magnetic susceptibility measurements performed on these compounds indicate (1) a small effective magnetic moment of 0.26(mu)(,B) on the Co atom and (2) anomalous behaviors in the Lu(,5)Rh(,4)Si(,10), Lu(,5)Ir(,4)Si(,10), Y(,5)Ir(,4)Si(,10), Lu(,5)Ir(,4)Ge(,10), and Y(,5)Rh(,4)Ge(,10) data. It is suggested that the same mechanism, namely, the forma- tion of a charge- or spin-density wave, is causing the anomalous behaviors in both the resistivity and susceptibility data. Lastly, upper critical magnetic field measurements were performed on Sc(,5)Co(,4)Si(,10), Sc(,5)Rh(,4)Si(,10), Sc(,5)Ir(,4)Si(,10), Lu(,5)Rh(,4)Si(,10), Lu(,5)Ir(,4)Si(,10), and Y(,5)Os(,4)Ge(,10). Relative to the other five samples, Y(,5)Os(,4)Ge(,10) exhibits very high values for (-dH(,c2)/dT)(,Tc) = 10.2 kOe/ K and H(,c2)(0) = 60.4 kOe. Comparing the value of (-dH(,c2)/dT)(,Tc) gained from the fit of the data to the WHH theory to the calculated (-dH(,c2)/dT)(,Tc) yields various degrees of agreement for these com- pounds. Indications are also that (1) there seems to be little or no. Pauli limiting and (2) the spin-orbit effect appears to be negligible in these compounds. *DOE Report IS-T-1215. This work was performed under contract No. W-7405-Eng-82 with the U. S. Department of Energy. ('1)A. Junod, D. Bichsel, and J. Muller, Helv. Phys. Acta 52, 580 (1979).

  4. 7 CFR 1415.4 - Program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., including the conservation, protection, enhancement, and, if necessary, restoration of the grassland... grazing management plan and any associated conservation plan or restoration agreement. (h) Easements and... conservation plan. (d) The easement or rental contract must grant USDA or its representatives a right of...

  5. Cognitive and Neural Sciences Division 1990 Programs

    DTIC Science & Technology

    1990-08-01

    operator skill acquisition for advanced manufacturing environments. In (W. Karawowski and M. Rahimi, Eds.) Ergonomics of Advanced Manufacturing and...PRINCIPAL INVESTIGATOR: John H. Maunsell University of Rochester Strong School of Medicine and Dentistry (716) 275-2076 R&T PROJECT CODE: 4424242 CONTRACT

  6. 48 CFR 619.803-70 - Responsibilities of the Office of Small and Disadvantaged Business Utilization (A/SDBU).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Responsibilities of the Office of Small and Disadvantaged Business Utilization (A/SDBU). 619.803-70 Section 619.803-70 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration...

  7. 7 CFR 1410.10 - Restoration of wetlands.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Restoration of wetlands. 1410.10 Section 1410.10... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION RESERVE PROGRAM § 1410.10 Restoration of wetlands. (a) An owner or operator who entered into a CRP contract on land that is suitable for...

  8. The Army Study Program.

    DTIC Science & Technology

    1980-10-09

    STUDDIES BY CATEGORY STUDY TITLE SPONSOR NMtTHOO PPA ADM RE:MOTE LINK PRUG DARCOM CONTRACT ADV TECH MODEL FULL DARCON CONTRACT ARMY COMMAND ANDi CONTROL...HOUUSE NUN -RLCURRIN 1 LMANUS DARCON I"-HUSL FF-TH-hLLI TM~k ECUNLNI(. ANALYSIS DARCOM CUNTRALT FOR SFELTKUM ANALYZERS UPLRA1IUN&L FLt)AI/EKPSL TKADL...TECHNULOGY A5 AESM:NT TRADOC bUTH *TEN YEAR INSTRUMENTATIOft ANALYSkIS OCSA ot" PHASE I TERRAIN MODELS DARCOM bUTH lEST CRITLRIA FUOR NUN -IIILLL-K WEAPUN

  9. Military Vision Research Program

    DTIC Science & Technology

    2011-07-01

    accomplishments emanating from this research . • 3 novel computer-based tasks have been developed that measure visual distortions • These tests are based...10-1-0392 TITLE: Military Vision Research Program PRINCIPAL INVESTIGATOR: Dr. Darlene Dartt...CONTRACTING ORGANIZATION: The Schepens Eye Research

  10. Effects of calcium channel blockers on the contractility of the filariid Acanthocheilonema viteae.

    PubMed

    Christ, D; Stillson, T

    1992-01-01

    The role of calcium in muscle contractility was explored in the filarial nematode Acanthocheilonema viteae (Dipetalonema viteae). The parasite was slit open longitudinally and mounted in a smooth-muscle chamber that had been filled with aerated (95% N2/5% CO2) physiological solution at 37 degrees C. Nifedipine (10(-6) M) and cadmium (3 x 10(-5) M) reduced the spontaneous isotonic contractions of A. viteae, whereas verapamil (10(-5) M) and diltiazem (10(-5) M) enhanced them. The effects of nifedipine and verapamil did not appear to be due to the solvent ethanol. All of the drugs reduced the maximal contraction induced by acetylcholine (ACh, 10(-5) M), although nifedipine was the most potent. After the exposure of worm preparations to a calcium-free medium containing ethyleneglycol-bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA, 10(-4) M) for 1 h, application of ACh (10(-5) M) induced a small, transient contraction. Subsequent applications of ACh in this medium had no effect. Thus, the nematode muscle contraction appears to depend on extracellular calcium. Nifedipine, diltiazem, and verapamil could act by reducing the calcium influx across the muscle membrane.

  11. Influence of hormone supplementation to extended semen on artificial insemination, uterine contractions, establishment of a sperm reservoir, and fertility in swine.

    PubMed

    Willenburg, K L; Miller, G M; Rodriguez-Zas, S L; Knox, R V

    2003-04-01

    This study was performed to quantify the effect of hormone addition to semen using a low-fertility model to evaluate its effectiveness and mode of action. At 24 h after the onset of estrus, all gilts received a single low-dose AI (0.5 x 10(9) sperm/80 mL) with no hormone (control, C), estrogens (E, 11.5 microg), PGF2alpha (PG, 5 mg of Lutalyse), or oxytocin (OT, 4 IU), which were then evaluated for semen backflow (n = 48), oviductal and uterine sperm numbers (n = 28), uterine contractions (n = 12), pregnancy rate (PR, n = 120), and number of fetuses (n = 67). In Exp. 1, backflow of semen from the uterus was collected for 8 h after AI, whereas PR and fetuses were assessed at d 25 to 30 after AI. In Exp. 2, backflow was collected and reproductive tracts flushed to determine sperm numbers in the oviducts and the anterior segments of the uterus. In Exp. 3, sows were monitored for uterine contractions for 1 h before AI and for 2 h after AI. In Exp. 1, there was a treatment x time interaction for fluid loss (P < 0.001), but by 8 h after AI, there was no difference in the total volume (70 +/- 1 mL) of semen lost between hormone treatments (85%) compared to controls (90%). There was also a treatment x time interaction (P < 0.05) for number of sperm lost in the backflow (2.1 +/- 0.1 x 10(8)), but by 8 h following AI, there was no effect on total sperm lost for the hormone treatments (38%) compared to C (54%). There was a trend (P = 0.10) for increased numbers of sperm in the uteri of hormone-treated gilts (6.0 +/- 1.3 x 10(4)) compared with C gilts (2.2 +/- 1.3 x 10(4), but there was no effect of treatment on sperm numbers in the oviducts (3.2 +/- 1.3 x 10(4)). Within 0.5 h of AI, there was an increase in the frequency of contractions for PG compared with the other treatments (14.2 vs. 6.3/h, P < 0.005), however there was no effect on amplitude (54 mmHg) or duration (35 s) of contractions. The PR was not influenced by treatment and averaged 54% (P > 0.60), but total numbers of healthy fetuses were increased (P < 0.04) by PG (8.7) and tended (P = 0.06) to be increased for OT (8.4), but not for E (7.2) compared to C (5.8). Hormone addition to semen increased numbers of fetuses and this may be related to an alteration in the pattern of fluid and sperm loss after AI and a tendency for increased numbers of sperm in the anterior segment of the uterus. Therefore, in situations of lowered fertility, hormone addition could be a strategy to limit infertility in swine.

  12. Graphene Oxide Annealing Procedures for Graphene-Based Supercapacitors

    DTIC Science & Technology

    2015-09-01

    Annealing Procedures for Graphene-Based Supercapacitors by Louis B Levine and Matthew H Ervin Sensors and Electron Devices Directorate, ARL...SUBTITLE Graphene Oxide Annealing Procedures for Graphene-Based Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  13. Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats.

    PubMed

    Zhang, Man; Zang, Kai-Hong; Luo, Jia-Lie; Leung, Fung-Ping; Huang, Yu; Lin, Cheng-Yuan; Yang, Zhi-Jun; Lu, Ai-Ping; Tang, Xu-Dong; Xu, Hong-Xi; Sung, Joseph Jao-yiu; Bian, Zhao-Xiang

    2013-11-15

    This study aimed to investigate the effect of magnolol (5,5'-diallyl-2,2'-biphenyldiol) on contraction in distal colonic segments of rats and the underlying mechanisms. Colonic segments were mounted in organ baths for isometric force measurement. Whole-cell voltage-sensitive L-type Ca(2+) currents were recorded on isolated single colonic smooth muscle cells using patch-clamp technique. The spontaneous contractions and acetylcholine (ACh)- and Bay K 8644-induced contractions were inhibited by magnolol (3-100 μM). In the presence of Bay K8644 (100 nM), magnolol (10-100 μM) inhibited the contraction induced by 10 μM ACh. By contrast, tetrodotoxin (100 nM) and Nώ-nitro-L-arginine methyl ester (L-NAME 100 μM) did not change the inhibitory effect of magnolol (10 μM). In addition, magnolol (3-100 μM) inhibited the L-type Ca(2+) currents. The present results suggest that magnolol inhibits colonic smooth muscle contraction through downregulating L-type Ca(2+) channel activity. Copyright © 2013 Elsevier GmbH. All rights reserved.

  14. The 2009 Influenza Pandemic: An Overview

    DTIC Science & Technology

    2009-08-06

    36 See, for example, the figure by sanofi pasteur (a flu vaccine manufacturer), “A (H1N1) Vaccine ... vaccine antigen and adjuvant. The funds will be used to place additional orders for bulk H1N1 antigen and adjuvant on existing contracts with sanofi ...national stockpile; launched efforts to develop, manufacture, and test a vaccine ; and enabled waivers of liability and a compensation program in the

  15. Photoinduced Electronic Energy Transfer: Theoretical and Experimental Issues for Light Harvesting Applications

    DTIC Science & Technology

    2013-10-21

    PHOTOINDUCED ELECTRONIC ENERGY TRANSFER - THEORETICAL AND EXPERIMENTAL ISSUES FOR LIGHT HARVESTING APPLICATIONS PAUL BRUMER UNIV OF TORONTO 10/21... Applications 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-10-1-0260 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...Harvesting Applications Grant Number: FA9550-10-1-0260 Program Manager: Dr. Tatjana Curcic, AFOSR Stated aims of the project

  16. 40 CFR 428.75 - Standards of performance for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... values for 30 consecutive days shall not exceed— Metric units (kg/kkg of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH (1) (1) English units (lb/1,000 lb of raw material) Oil and grease 0.26 0...— Metric units (kg/kkg of raw material) Lead 0.0017 0.0007 English units (lb/1,000 lb of raw material) Lead...

  17. 40 CFR 428.75 - Standards of performance for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... values for 30 consecutive days shall not exceed— Metric units (kg/kkg of raw material) Oil and grease 0.26 0.093 TSS 0.50 0.25 pH (1) (1) English units (lb/1,000 lb of raw material) Oil and grease 0.26 0...— Metric units (kg/kkg of raw material) Lead 0.0017 0.0007 English units (lb/1,000 lb of raw material) Lead...

  18. 75 FR 41793 - Child and Adult Care Food Program: National Average Payment Rates, Day Care Home Food Service...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... adjustments to the national average payment rates for meals and snacks served in child care centers, outside... payment rates for meals and snacks served in day care homes; and the administrative reimbursement rates...] Lunch and Centers Breakfast supper \\1\\ Snack Contingous States: Paid 0.26 0.26 0.06 Reduced Price 1.18 2...

  19. 10 CFR 961.11 - Text of the contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

  20. 10 CFR 961.11 - Text of the contract.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

  1. 48 CFR 9903.202 - Disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202 Disclosure requirements. ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Disclosure requirements. 9903.202 Section 9903.202 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD...

  2. 48 CFR 970.2671 - Diversity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Diversity. 970.2671 Section 970.2671 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2671 Diversity. ...

  3. Effects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferens.

    PubMed

    Pedroso, Shaista Poppe; de Souza, Bruno Palmieri; Jurkiewicz, Aron; Juriewicz, Neide H; da Silva Junior, Edilson Dantas

    2017-03-01

    It is described that fluoxetine treatment is able to induce ejaculatory disorders. However, the exact mechanism is still not fully understood. Therefore, this study was carried out to further evaluate the anti-ejaculatory effects of fluoxetine, using different approaches (in vitro or in vivo treatments), on the sympathetic neurotransmission of the rat vas deferens. Vas deferens from male Wistar rats were used to check the in vitro effects of fluoxetine 10 -6 M, 3.10 -6 M or 10 -5 M. Animals were also acutely (20mg/kg, i.p. 4h or 24h) or chronically (10mg/kg, i.p., 30days) treated with fluoxetine or drug-free vehicle. The vas deferens from non-treated and treated animals were isolated and mounted in an isolated organ bath for the study of the contractions induced by adrenergic agonists, tyramine, 5-HT, Ca 2+ or electrical field stimulation. In vitro or acute treatment with fluoxetine decreased the contraction induced by agonists, Ca 2+ or electrical field stimulation. The chronic treatment with fluoxetine decreased the contractions induced agonists, tyramine or Ca 2+ , but did not modify the contractions induced by electrical field stimulation. We have shown that in vitro or in vivo fluoxetine treatment is able to alter the sympathetic neurotransmission of the rat vas deferens which could be related to alterations in the calcium signalling. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Transmutation and activation of reduced activation ferritic martensitic steel in molten salt cooled fusion power plants

    NASA Astrophysics Data System (ADS)

    Cheng, E. T.

    2004-08-01

    Neutron activation analysis was conducted for the reduced activation ferritic/martensitic (RAFM) steel used in flibe molten-salt cooled fusion blankets. After 22.4 MW yr/m 2 of neutron exposure, the RAFM steel first wall in a molten salt blanket with 40% lithium-6 enrichment in lithium was found to be within 1 mSv/h in contact dose rate after 100 yr of cooling. The contact dose rate drops to 30 and 20 μSv/h or less, respectively, when the cooling times are 300 and 500 yr after discharge. The RAFM steel discharged from the high-temperature shield component would be allowed for hands-on recycling after 100 yr of cooling, when the contact dose rate is 10 μSv/h or less. The most significant changes found in the RAFM steel first wall due to nuclear transmutation, are 10% decrease in W and 10% increase in Ti. Additionally, there are minor elements produced: Mn - <1.2%, V - <0.26%, Re - <0.2%, Ta - <0.08%, and Os - <0.1%, all in weight percent. The gaseous elements generated are H and He, and the, respectively, accumulated quantities are about 260 and 190 wppm.

  5. Advanced Manufacturing Process for Lower Cost Rechargeable Lithium-ion Batteries for DOD Including the BB2590

    DTIC Science & Technology

    2013-11-30

    Rechargeable Lithium-ion Batteries for DOD Including the BB2590 Contract #SP4701-10-C-0032 Submitted by LithChem Energy (Div. of Retriev...Lithium-ion Batteries for DOD Including the BB2590 5a. CONTRACT NUMBER AP4701-10-C-0032 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...automated lithium-ion bi-cell production machine to produce lower cost prismatic lithium-ion batteries for the DOD. This machine was completed and

  6. APPS-IV Civil Works Data Extraction/Data Base Application Study

    DTIC Science & Technology

    1982-09-01

    QA 1 2 3 889 ETL-031 0 APPS-IV civil works data extraction/data base application study (phase 1) Jonathan C. Howland Autometric, Incorporated 5205... STUDY FINAL REPORT (PHASE I) 6. PERFORMING ORG. REPORT NUMBER 900-0081 7. AUTHOR(@) S. CONTRACT ON GRANT NUMBER(B) DAAK70-8 I -C-026 1 Jonathan C...CAPIR system was applied to a flood damage potential study . The particular applications were structure mapping and land use interpretation. A Civil

  7. Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle

    PubMed Central

    Sandström, Marie E; Zhang, Shi-Jin; Bruton, Joseph; Silva, José P; Reid, Michael B; Westerblad, Håkan; Katz, Abram

    2006-01-01

    Exercise increases glucose transport into skeletal muscle via a pathway that is poorly understood. We investigated the role of endogenously produced reactive oxygen species (ROS) in contraction-mediated glucose transport. Repeated contractions increased 2-deoxyglucose (2-DG) uptake roughly threefold in isolated, mouse extensor digitorum longus (fast-twitch) muscle. N-Acetylcysteine (NAC), a non-specific antioxidant, inhibited contraction-mediated 2-DG uptake by ∼50% (P < 0.05 versus control values), but did not significantly affect basal 2-DG uptake or the uptake induced by insulin, hypoxia or 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR, which mimics AMP-mediated activation of AMP-activated protein kinase, AMPK). Ebselen, a glutathione peroxidase mimetic, also inhibited contraction-mediated 2-DG uptake (by almost 60%, P < 0.001 versus control values). Muscles from mice overexpressing Mn2+-dependent superoxide dismutase, which catalyses H2O2 production from superoxide anions, exhibited a ∼25% higher rate of contraction-mediated 2-DG uptake versus muscles from wild-type control mice (P < 0.05). Exogenous H2O2 induced oxidative stress, as judged by an increase in the [GSSG]/[GSH + GSSG] (reduced glutathione + oxidized glutathione) ratio to 2.5 times control values, and this increase was substantially blocked by NAC. Similarly, NAC significantly attenuated contraction-mediated oxidative stress as judged by measurements of glutathione status and the intracellular ROS level with the fluorescent indicator 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein (P < 0.05). Finally, contraction increased AMPK activity and phosphorylation ∼10-fold, and NAC blocked ∼50% of these changes. These data indicate that endogenously produced ROS, possibly H2O2 or its derivatives, play an important role in contraction-mediated activation of glucose transport in fast-twitch muscle. PMID:16777943

  8. GOT C+ Survey of Transition Clouds in the Inner Galaxy

    NASA Astrophysics Data System (ADS)

    Velusamy, Thangasamy; Langer, W. D.; Pineda, J. L.; Goldsmith, P. F.; Li, D.; Yorke, H. W.

    2010-05-01

    To understand star formation and the lifecycle of the interstellar gas we need detailed information about the transition of diffuse atomic to molecular clouds. The C+ line at 1.9 THz traces a so-far poorly studied stage in cloud evolution - the transitional clouds going from atomic HI to molecular H2 The transition cloud phase, which is difficult to observe in HI and CO alone, may be best characterized via CII emission or absorption. Here we present the first results on transition clouds along a few representative lines of sight in the inner Galaxy from longitude 325 degrees to 10 degrees, observed under the GOT C+ program, a HIFI Herschel Key Project to study the diffuse ISM. We can separate out the different ISM components along each line of sight by comparisons of the high spectral resolution ( 1 km/s) and high sensitivity (rms 0.1 K to 0.2 K) HIFI data on C+ with HI, 12CO, and 13CO spectra. These observations are being carried out with the Herschel Space Observatory. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration. JLP is supported under the NASA Postdoctoral Program at JPL, Caltech, administered by Oak Ridge Associated Universities through a contract with NASA.

  9. Cardiovascular response to prescribed detraining among recreational athletes.

    PubMed

    Pedlar, Charles R; Brown, Marcel G; Shave, Robert E; Otto, James M; Drane, Aimee; Michaud-Finch, Jennifer; Contursi, Miranda; Wasfy, Meagan M; Hutter, Adolph; Picard, Michael H; Lewis, Gregory D; Baggish, Aaron L

    2018-04-01

    Exercise-induced cardiac remodeling (EICR) and the attendant myocardial adaptations characteristic of the athlete's heart may regress during periods of exercise reduction or abstinence. The time course and mechanisms underlying this reverse remodeling, specifically the impact of concomitant plasma volume (PV) contraction on cardiac chamber size, remain incompletely understood. We therefore studied recreational runners ( n = 21, age 34 ± 7 yr; 48% male) who completed an 18-wk training program (~7 h/wk) culminating in the 2016 Boston Marathon after which total exercise exposure was confined to <2 h/wk (no single session >1 h) for 8 wk. Cardiac structure and function, exercise capacity, and PV were assessed at peak fitness (10-14 days before) and at 4 wk and 8 wk postmarathon. Mixed linear modeling adjusting for age, sex, V̇o 2peak , and marathon finish time was used to compare data across time points. Physiological detraining was evidenced by serial reductions in treadmill performance. Two distinct phases of myocardial remodeling and hematological adaptation were observed. After 4 wk of detraining, there were significant reductions in PV (Δ -6.0%, P < 0.01), left ventricular (LV) wall thickness (Δ -8.1%, <0.05), LV mass (Δ -10.3%, P < 0.001), and right atrial area (Δ -8.2%, P < 0.001). After 8 wk of detraining, there was a significant reduction in right ventricle chamber size (end-diastolic area Δ = -8.0%, P < 0.05) without further concomitant reductions in PV or LV wall thickness. Abrupt reductions in exercise training stimulus result in a structure-specific time course of reverse cardiac remodeling that occurs largely independently of PV contraction. NEW & NOTEWORTHY Significant reverse cardiac remodeling, previously documented among competitive athletes, extends to recreational runners and occurs with a distinct time course. Initial reductions in plasma volume and left ventricular (LV) mass, driven by reductions in wall thickness, are followed by contraction of the right ventricle. Consistent with data from competitive athletes, LV chamber volumes appear less responsive to detraining and may be a more permanent adaptation to sport.

  10. 41 CFR 109-45.1002-3 - Precious metals recovery program monitor.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program monitor. 109-45.1002-3 Section 109-45.1002-3 Public Contracts and Property Management Federal... UTILIZATION AND DISPOSAL 45-SALE, ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.10-Recovery of Precious Metals § 109-45.1002-3 Precious metals recovery program monitor. The DPMO shall be the precious metals...

  11. 48 CFR 1522.608 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Procedures. 1522.608 Section 1522.608 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act 1522.608...

  12. 48 CFR 570.602 - GSAR solicitation provisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false GSAR solicitation provisions. 570.602 Section 570.602 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY Solicitation Provisions and...

  13. 48 CFR 1523.703 - Policies and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policies and procedures. 1523.703 Section 1523.703 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SOCIOECONOMIC PROGRAMS ENVIRONMENTAL, CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Contracting for...

  14. 48 CFR 570.106 - Publicizing/Advertising.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Publicizing/Advertising. 570.106 Section 570.106 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY General 570.106 Publicizing/Advertising...

  15. 48 CFR 1330.202 - Disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure requirements. 1330.202 Section 1330.202 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1330.202 Disclosure...

  16. 48 CFR 1430.202 - Disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure requirements. 1430.202 Section 1430.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1430.202 Disclosure...

  17. 48 CFR 30.202 - Disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Disclosure requirements. 30.202 Section 30.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202 Disclosure...

  18. 48 CFR 430.202 - Disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Disclosure requirements. 430.202 Section 430.202 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202 Disclosure...

  19. 48 CFR 570.102 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Definitions. 570.102 Section 570.102 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY General 570.102 Definitions. Acquisition means the...

  20. 48 CFR 30.202 - Disclosure requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Disclosure requirements. 30.202 Section 30.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202 Disclosure...

  1. 48 CFR 1330.202 - Disclosure requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Disclosure requirements. 1330.202 Section 1330.202 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1330.202 Disclosure...

  2. 48 CFR 1430.202 - Disclosure requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Disclosure requirements. 1430.202 Section 1430.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1430.202 Disclosure...

  3. 48 CFR 430.202 - Disclosure requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Disclosure requirements. 430.202 Section 430.202 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202 Disclosure...

  4. 48 CFR 2427.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses. ...

  5. 48 CFR 2427.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses. ...

  6. 48 CFR 2427.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses. ...

  7. 48 CFR 2427.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses. ...

  8. 48 CFR 2427.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Administration of patent... AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 2427.305 Administration of patent rights clauses. ...

  9. 48 CFR 825.870 - Technical assistance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Technical assistance. 825... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements and Coordination 825.870 Technical assistance. Contracting officers may obtain technical information or guidance on international agreements and...

  10. 48 CFR 32.409-1 - Recommendation for approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Recommendation for... Recommendation for approval. If recommending approval, the contracting officer shall transmit the following... authorization (see 32.410). (g) The recommendation for approval of the advance payment request. (h...

  11. Control Beliefs and Cognition Over a 10-year Period: Findings from the ACTIVE Trial

    PubMed Central

    Parisi, Jeanine M.; Gross, Alden L.; Marsiske, Michael; Willis, Sherry L.; Rebok, George W.

    2017-01-01

    We examined two facets of control beliefs and cognition over ten-years within the ACTIVE cognitive training program. Intellectual Self-efficacy decreased (β = −0.32 units/year; SE = 0.03) and Concern about Intellectual Aging increased (β = 0.26 units/year; SE = 0.02) over time, with older age being the only predictor of increases in Concern about Intellectual Aging. Although baseline cognitive performance was related to control beliefs over time, the reverse was not supported. Findings were not altered by participation in the ACTIVE training programs, suggesting the need for including intervention components that lead to long-term maintenance or improvements in such beliefs. PMID:28182498

  12. The effect of DDT and its metabolite (DDE) on prostaglandin secretion from epithelial cells and on contractions of the smooth muscle of the bovine oviduct in vitro

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wrobel, Michal H.; Mlynarczuk, Jaroslaw; Kotwica, Jan, E-mail: janko@pan.olsztyn.pl

    2012-03-01

    The insecticide DDT and its metabolite (DDE), due to their lipolytic nature and resistance to biodegradation, are accumulated in the living tissues. In cows, DDT and DDE were found to affect prostaglandin (PG) secretion from the endometrium and contractions of the myometrium. In this study, the impact of both xenobiotics (0.1, 1, 10 or 100 ng/ml) on the function of epithelial cells and muscle strips of bovine oviducts from 1 to 5 day of the oestrous cycle was examined. Therefore the concentration of PGE2 and PGFM (a metabolite of PGF2α) in culture media, mRNA expression of genes involved in PGsmore » synthesis in epithelial cells and the force and amplitude of strips contractions were measured after 2 and 24 or 48 h of incubation. Neither DDT nor DDE affected the viability of cells after 48 h (P > 0.05). Both DDT and DDE increased the concentrations of PGFM in culture medium and secretion of PGE2 after only 2 h of cell culture (P < 0.05). Similar effects were seen for the influence of DDE on amount of PGFM after 48 h, while DDT decreased secretion of PGE2 (P < 0.05). DDT after 2 h increased (P < 0.05) mRNA expression of PGF2α synthase (PGFS), while both xenobiotics decreased (P < 0.05) mRNA expression of cyclooxygenase-2 (COX-2) after 24 h. DTT also increased the force of isthmus contractions after 2 h, as did both xenobiotics after 48 h (P < 0.05). Moreover, after 2 and 48 h, DDE stimulated the amplitude of contractions of the isthmus as well as the ampulla, (P < 0.05). The effect of both compounds on oviduct contractions was diminished by indomethacin, which blocks PG synthesis. We conclude that oviductal secretion of prostaglandins is affected, by DDT and DDE. The influence of these xenobiotics on PGF2α and PGE2 secretion and ratio may be part of the mechanism by which both DDT and its metabolite disturb the contractions of oviductal muscle. -- Highlights: ► DDT and its metabolite – DDE are accumulated in the living tissues. ► The insecticides affected PGF2α and PGE2 release from epithelial cells of oviduct. ► They also stimulated markedly the contractions of oviductal strips. ► Prostaglandins were involved in the effect of insecticides on oviduct function.« less

  13. Sex differences in neuromuscular function after repeated eccentric contractions of the knee extensor muscles.

    PubMed

    Lee, Andrea; Baxter, Jake; Eischer, Claire; Gage, Matt; Hunter, Sandra; Yoon, Tejin

    2017-06-01

    This study examined the mechanisms for force and power reduction during and up to 48 h after maximal eccentric contractions of the knee extensor muscles in young men and women. 13 men (22.8 ± 2.6 years) and 13 women (21.6 ± 2.2 years) performed 150 maximal effort eccentric contractions (5 sets of 30) with the knee extensor muscles at 60° s -1 . Maximal voluntary isometric contractions (MVIC) and maximal voluntary concentric contractions (MVCC) were performed before and after the 150 eccentric contractions. The MVCCs involved a set of two isokinetic contractions at 60° s -1 and sets of isotonic contractions performed at seven different resistance loads (1 N m, 10, 20, 30, 40, 50, and 60% MVIC). Electrical stimulation was used during the MVICs and at rest to determine changes in voluntary activation and contractile properties. At baseline, men were stronger than women (MVIC: 276 ± 48 vs. 133 ± 37 N m) and more powerful (MVCC: 649 ± 77 vs. 346 ± 78 W). At termination of the eccentric contractions, voluntary activation, resting twitch amplitude, and peak power during concentric contractions at the seven loads and at 60° s -1 decreased (P < 0.05) similarly in the men and women. At 48 h post-exercise, the MVIC torque, power (for loads ≥20-60% MVIC), and voluntary activation remained depressed (P < 0.05), but the resting twitch had returned to baseline (P > 0.05) with no sex differences. Central mechanisms were primarily responsible for the depressed maximal force production up to 48 h after repeated eccentric contractions of the knee extensors and these mechanisms were similar in men and women.

  14. Carbachol induces Ca(2+)-dependent contraction via muscarinic M2 and M3 receptors in rat intestinal subepithelial myofibroblasts.

    PubMed

    Iwanaga, Koichi; Murata, Takahisa; Okada, Muneyoshi; Hori, Masatoshi; Ozaki, Hiroshi

    2009-07-01

    Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine. Nerve endings distribute adjacent to IMFs, suggesting neurotransmitters may influence IMFs motility; however, there is no direct evidence showing the interaction. Here, we isolated IMFs from rat colon and investigated the effect of acetylcholine on IMFs contractility. In the collagen gel contraction assay, carbachol (1 - 10 microM) and the muscarinic receptor agonist bethanechol (30 - 300 microM) dose-dependently induced IMFs contraction. Pretreatment with the muscarinic receptor antagonist atropine (1 - 10 nM) inhibited carbachol-induced contraction. In RT-PCR, mRNA expression of all muscarinic receptor subtypes (M(1) - M(5)) was detected in IMFs. Subsequently we found pretreatment with the muscarinic M(2) receptor antagonist 11-([2-[(diethylamino)methyl]-1-piperdinyl]acetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one (AF-DX116) (10 and 30 nM) or the muscarinic M(3) receptor antagonist 4-diphenylacetoxy-N-methyl-piperidine (4-DAMP) (3 and 10 nM) dose-dependently inhibited carbachol-induced contraction. In Ca(2+) measurement, 1 - 10 microM carbachol and 30 - 300 microM bethanechol elevated the intracellular Ca(2+) concentration ([Ca(2+)](i)) in IMFs. Atropine (10 nM) eliminated carbachol-induced [Ca(2+)](i) elevation. The Ca(2+)-channel blocker LaCl(3) (3 microM) abolished carbachol-induced [Ca(2+)](i) elevation and contraction. Furthermore, AF-DX116 and 4-DAMP dose-dependently inhibited the carbachol-induced [Ca(2+)](i) elevation. These observations suggest that acetylcholine elicits Ca(2+)-dependent IMF contraction through muscarinic M(2) and M(3) receptors.

  15. Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle.

    PubMed

    James, Arlene N; Ryan, James P; Parkman, Henry P

    2003-08-01

    Botulinum toxin injection into the pylorus is reported to improve gastric emptying in gastroparesis. Classically, botulinum toxin inhibits ACh release from cholinergic nerves in skeletal muscle. The aim of this study was to determine the effects of botulinum toxin on pyloric smooth muscle. Guinea pig pyloric muscle strips were studied in vitro. Botulinum toxin type A was added; electric field stimulation (EFS) was performed every 30 min for 6 h. ACh (100 microM)-induced contractile responses were determined before and after 6 h. Botulinum toxin caused a concentration-dependent decrease of pyloric contractions to EFS. At a low concentration (2 U/ml), botulinum toxin decreased pyloric contractions to EFS by 43 +/- 9% without affecting ACh-induced contractions. At higher concentrations (10 U/ml), botulinum toxin decreased pyloric contraction to EFS by 75 +/- 7% and decreased ACh-induced contraction by 79 +/- 9%. In conclusion, botulinum toxin inhibits pyloric smooth muscle contractility. At a low concentration, botulinum toxin decreases EFS-induced contractile responses without affecting ACh-induced contractions suggesting inhibition of ACh release from cholinergic nerves. At higher concentrations, botulinum toxin directly inhibits smooth muscle contractility as evidenced by the decreased contractile response to ACh.

  16. Navy Stock Point Local Unique Computer Programs: An Analysis for Transition and Management Under the Stock Point ADP Replacement (SPAR) Project.

    DTIC Science & Technology

    1987-03-01

    Project (SPAR). An impor- tant issue of the replacement will be the conversion of existing co uter software to allow transition from the current... issue of the replacement will be the conversion of existing computer software to allow transition from the current hardware environment to the replacement...36 G. LOCAL PROGRAM C1/C2 CONVERSION CONTRACT . . . 38 5 H. LOCAL PROGRAM COMMONALITY ISSUES ....... 41 I. SUMMARY

  17. Coal gasification systems engineering and analysis. Appendix H: Work breakdown structure

    NASA Technical Reports Server (NTRS)

    1980-01-01

    A work breakdown structure (WBS) is presented which encompasses the multiple facets (hardware, software, services, and other tasks) of the coal gasification program. The WBS is shown to provide the basis for the following: management and control; cost estimating; budgeting and reporting; scheduling activities; organizational structuring; specification tree generation; weight allocation and control; procurement and contracting activities; and serves as a tool for program evaluation.

  18. 48 CFR 22.604 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Exemptions. 22.604 Section 22.604 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act 22.604 Exemptions. ...

  19. 48 CFR 22.1003 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Applicability. 22.1003 Section 22.1003 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22...

  20. 48 CFR 1322.1001 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Definitions. 1322.1001 Section 1322.1001 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 1322.1001...

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