Nature of Short Li...H-C Contact Interactions in Organolithium Compounds and Its Implication

DTIC Science & Technology

1992-05-15

LIMITATION OF ABSTRACT OF REPORT OF THIS PAGE I OF ABSTRACT Unclassified 1 Unclassified Unclassified UL NSN 75403-01-2t^,5500 Standard Formn 296 (Rev 2-89...Pm NS it 1 ~. OFFICE OF NAVAL RESEARCH Contract N00014-90-J-1159 R&T Code 413n007 Technical Report No. 14 Nature of Shtt Lliwlio Contact Interactions...Implication HL1-AH- 3 C, 1 .o 10o M0)" Juan J. Novoa-t and Myung-Hwan Whangbo HIU-H-CHI Ce, 510 00 (043" sCalaalated with the 64t++G bsis et mrt the gee

7 CFR 1726.304 - List of electric program standard contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false List of electric program standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES RUS Standard Forms § 1726.304 List of electric program standard contract forms. (a) General. This section...

United States Air Force Summer Faculty Research Program. Program Technical Report. 1990. Volume 1

DTIC Science & Technology

1991-06-05

aft"W--0" II I i 1. A -- U14 ONLY (L ..... h .REPORT DAE J P WORT N-vt A A CVEE . . ftW NO 55 June 1991 IAnnual/Fna Set 89൧-Aug 90 4.OW ARDMORBUnited...States Air Force Summer Faculty Research Program 1990 \\3oVxx’( \\Q )? J . Program Technical Report 2 & AUTOR() F49620-88-C-0053 Mr Rodney Darrah 7.Pg...PAGE OF ASTA. rUNCLASSIFIED UNCLASSTPTFn r~TTI ~ a. - h I "AEOSR*TR* 91 O~’~8 rJ2c) ~ H4- h’ tfi ~ t( -4 C. b.t1:~ ~jr - J :1 Ii 4 ( CD UNITED STATES

Development of a Behaviorally Anchored Rating Scale for Leadership

DTIC Science & Technology

2018-01-01

Research Product 2018-06 Development of a Behaviorally Anchored Rating Scale for Leadership Tatiana H. Toumbeva Krista L...anchored Rating Scale for Leadership 5a. CONTRACT NUMBER W5J9CQ-11-D-0004 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62278 6...observer- based behavioral measure to help instructors more reliably and accurately evaluate the development of leadership attributes and competencies

Innovative Phase Change Approach for Significant Energy Savings

DTIC Science & Technology

2016-09-01

September 2016 Innovative Phase Change Approach For Significant Energy Savings September 2016 8 After conducting a market survey...FINAL REPORT Innovative Phase Change Approach for Significant Energy Savings ESTCP Project EW-201138 SEPTEMBER 2016 Dr. Aly H Shaaban Applied...5a. CONTRACT NUMBER W912HQ-11-C-0011 Innovative Phase Change Approach for Significant Energy Savings 5b. GRANT NUMBER 5c. PROGRAM

78 FR 3952 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

.... For Select Symbols (excluding SPY), the Exchange currently provides a base rebate of $0.34 per... SPY), the Exchange currently provides a base rebate of $0.34 per contract, per leg, for Priority... Securities Exchange Act of 1934 (the ``Act''),\\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that...

Improved H mode with flat central q profile on EAST

NASA Astrophysics Data System (ADS)

Liu, Haiqing; Yang, Yao; Gao, Xiang; Zeng, Long; Qian, Jinping; Gong, Xianzu; Wan, Baonian; Ding, Weixing; Brower, David Lyn; EAST Team

2017-10-01

High betaN ( 1.8) plasma with good confinement (H98y2 1.1) on EAST tokamak has been reported recently. These ELMy H-mode plasmas with Bt = 1.6T, Ip = 400 kA and q95 4.5 were heated by lower hybrid wave and neutral beam injection. The internal transport barrier (ITB) and edge transport barrier (ETB) are both observed with m/n =1/1 fishbone, which were identified to clamp central q at values close to unity. Implying an improved H-mode with flat central q profile and absence of sawteeth, like other devices. Accurate q profile, key profile for developing scenarios aim at high performance H mode, were derived by Polarimeter-interferometer (POINT) measurement as constraint. Base on the optimized current profile, better confinement (H98y2 1.4) with an electron ITB was obtained also with flat central q profile and absence of sawteeth at high betaP ( 2) regime with Bt = 2.5T, Ip = 400 kA. Both high betaN regime and high betaP regime H mode, are characterized by a stationary flat central q profile q0 >=1, but typically close to 1, absence of sawteeth, H98(y,2) >1 and simultaneously, with ITB. This work is supported by the National Magnetic Confinement Fusion Program of China with Contract No. 2014GB106002 and partly supported by the US D.O.E. contract DESC0010469.

All Prime Contract Awards by State or Country, Place, and Contractor. Part 14 (Akron, New York-Wilson, North Carolina)

DTIC Science & Technology

1990-01-01

i4 i-N( 000U or- L-4ɘ 0-4 0- ɘin L-- )CO 1-00 V) 11 034 Was00 Mtn0 40 00 (90 NO inO -400 -100 ,-411 I.1 . : I Iz o I of 103 - 110 nin I -4 -I 0 in w...4 U- 103 (0< If 0 0 0000 00000000 0 00 00000000 0 : ID ::O4I 00 00 000400 000000000 00 0. ~0 000000000o 0M If M (40 < I-4 4 14 44 .. ൴ -4-4 -i1--i -4...xzz xzzzzzzz MO) :: ax ZZ OZZZZ* a) z o z Q)Zzzz* 4)z O)zz* wzzzzzzz I moo it Z z z Z z I z z z 4D I moo 11 0) QC>00 11 cn a a) PD In In ",4 *4D-qamr-m

Antiviral activity of a synthesized shikonin ester against influenza A (H1N1) virus and insights into its mechanism.

PubMed

Zhang, Yahan; Han, Hongwei; Qiu, Hanyue; Lin, Hongyan; Yu, Lugang; Zhu, Wanzhan; Qi, Jinliang; Yang, Rongwu; Pang, Yanjun; Wang, Xiaoming; Lu, Guihua; Yang, Yonghua

2017-09-01

This study aimed to examine the antiviral effects of shikonin ester ((R)-1-(5, 8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl3-(1H- indol-3-yl) propanoate (PMM-034) against influenza A (H1N1) virus. We investigated PMM-034 anti-H1N1 activity and its effect on caspase 3 gene expression during cellular apoptosis after influenza virus infection in vitro. Neuraminidase (NA) inhibition was assessed in comparison with oseltamivir in the influenza virus standard strains A/PR/8/34 to understand the viral mechanism. MDCK and A549 cells were used to investigate influenza viral infection and the structure-activity relationship between PMM-034 and NA was evaluated by pharmacophore-based docking modeling. The production of viral protein was tested by western blot. A/PR/8/34 induced cell inhibition but this was reduced by PMM-034 to 16μg/mL and this showed a selective index of 10mM. PMM-034 inhibited NA in a dose dependent manner, similar to oseltamivir inhibition. A sharp decrease in viral nucleocapsid protein mRNA was observed in infected cells after treatment with PMM-034. Apoptosis of infected A459 cells was inhibited by PMM-034 with decreased caspase 3 levels. ARG 118, ARG 152, ARG 371 and GLU 227 in the binding pocket of NA bound to PMM-034 in the docking model. Taken together, these results suggest PMM-034 shikonin ester blocked H1N1 infection and might be a potential anti-H1N1 drug. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Resource Applications In - Seton Hall University). Part 16

DTIC Science & Technology

1994-03-01

ZNjC u cci C I UOM 0 11) 131 n" ൞ 13 ŗ .) a U04 d =M-ZMXZ a zz ZZZZ z zxZZ MN U0) N 0 41C4444 0 4 c 44444 Go 00 򓤜 4 C II 1UON 100 00 000 ow 0 0...MVWWC4 Vf-C 11 1(0( Coo OD 1 ) 0 .. 00 e 41 vn oo 1 4- W N e n V Cc (000 Go 1 11 u I (o00Go It 4 I c 1 : 100 (0 It LA 10 o00to Cc11 (0 N 1 ---4- - - ---4-4...0: o-- O 0 In 0 0 0 0 o0oloa K CL4 100 *w I w. 034-: o o o o o o o o o o o oo o o o NnI aiCVL K* K L-N K NNNNNNNNNNNNNNNNNNNNNNNNN N N N N N K Li-.- K

75 FR 32638 - Defense Federal Acquisition Regulation Supplement; Contract Authority for Advanced Component...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Prototype Units (DFARS Case 2009-D034) AGENCY: Defense Acquisition Regulations System, Department of Defense... Component Development or Prototype Units.'' Section 819 is intended to prevent a contract for new technology... development of advanced components or the procurement of prototype units. To do so, section 819 places...

7 CFR 634.11 - Availability of funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Availability of funds. 634.11 Section 634.11..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding § 634.11 Availability of funds. (a) The provisions of the program are subject to the appropriation of...

Handbook of Phase Transition Sulfides, Selenides and Tellurides,

DTIC Science & Technology

1984-07-01

guidance and control. The Contracting Officer is Mrs. S. Williams, DESC, Dayton, Ohio. The Contracting Officers Technical Representative is Mr. H . C...higher temperature phase change where AgGaS2 becomes metallic. REFERENCES (AgGaS2 ) 1. H . Hahn, et.al., Z. Anorg. Chem., 271, 153 (1953). 2. M.V. Hobden...Phys. Soc. Japan, Vol. 23, 37 (1967). 10. H.H. Dorner, H.P. Geserich, and H . Rickert, Phys. Stat. Sol. (a), Vol. 37, K85 (1970). 11. P. Bruesch and J

On the Importance of Displacement History in Soft-Body Contact Models

DTIC Science & Technology

2015-07-10

Plimpton , S . J., 2001. “Granular flow down an inclined plane: Bagnold scaling and rheol- ogy”. Physical Review E, 64(5), p. 051302. [16] Zhang, H. P...Models 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) US Army RDECOM-TARDEC,6501 E. 11 Mile Road,Warren,MI,48397-5000 8. PERFORMING ORGANIZATION REPORT

The Role of Frame Force in Quantum Detection

DTIC Science & Technology

2007-01-01

42040) 10. C. H. Bennett, Quantum cryptography using any two nonorthogonal states, Phys. Rev. Lett. 68 (1992), no. 21, 3121–3124. MR 1 163 546 11. S ...SUBTITLE The Role of Frame Force in Quantum Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT...equivalent to a quantum detection problem from quantum mechanics. To this end we first reformulate Problem 1.2 in terms of orthonormal bases instead of 1

Nuclear Factor-Kappa B Activity in the Host-Tumor Microenvironment of Ovarian Cancer

DTIC Science & Technology

2014-10-01

CONTRACT NUMBER Cancer 5b. GRANT NUMBER W81XWH-11-1-0509 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dr. Andrew Wilson 5d. PROJECT NUMBER...NGL syngeneic model. OCRP Pilot Project Award 2014. [no appendix entry] - pending 13 CONCLUSIONS The hypothesis to be tested is...Biographical Sketches, each item identified as a ‘reportable outcome’ for this project is included in appendices. 1. AJ Wilson, H-J Lee, WJ Barham, L Chen

Advanced Development Model (ADM) Program for the Shipboard Meteorological and Oceanographic Observing System (SMOOS).

DTIC Science & Technology

1986-05-20

SOURCE DOCUMENTS 1. N62269-84- R -0309 SHOOS Request for Proposal (RFP) 2. N62269-84-C-0309, SOOS Advanced Development Model (ADM) Contract 3. SA-TS-7833...b.n . II ii t .. ~ r 5* t **v *...to, $me$ d.v.... 0", tc htlo I . .. vtod. - BT 9S.td Fig. 3.5- Susse Funtina AlloatinMtri ittnits 0~~~~~~4. vii...LSyes T ttiL e Request To r Transmit 9 Upper Air II aaDspDatalay *S Ocear Sea Depth I71 dg I Dept Data3ttu tts Data Display Data Display Controller

All Prime Contract Awards by State or Country, Place and Contractor. Part 14. (Aberdeen, North Carolina-Zanesville, Ohio)

DTIC Science & Technology

1989-01-01

J M < 0 0 a U) L) W-4 Z I-1 L) z M > -a I-I CC 011-4 100 -4 to c) r- w 04 00 ow < 00 CL C,) ww CO-4 11 orlr w C 131 : In 0-400 wo 0 -. 100 - M LAJ -0...00 00 m 00 󈧄 00 𔃺 jl) ’l, 10 000000 N I03-4C4n0 it CO %) CO CO cOO COi m0 CO mCOm ( COOOOCIJCI NI 00- 100 11 - 40 c4 -c40 -400 ’-4La1 c 04 -󈧄 a.4...41 100 M 04 1- (A 0 L- C-4 1-0 IlIN IW W 2 zA Oc 1- 0 00 :10 " . - -4 ) U - >-0 l’ 11E100E II mm c’. K c- u- l’- U 01Ito I MN < 1-4 4 .- o) z4 0) CA

A Female Urinary Diversion Device for Military Women in the Deployed Environment

DTIC Science & Technology

2016-10-27

9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones...reported there were many opportunities for a FUDD due to unsanitary and challenging conditions. Implications for Military Nursing : This research...Contract PoP: 6/1/2011 - 5/31/2016 Customer: TRISERVICE NURSING RESEARCH PROGRAM Customer Contract ID: HU0001 -11-1-TS02 Contract Manager: Robinson

Iowa Developed Energy Activity Sampler (IDEAS), Grades 7-12: Industrial Arts.

ERIC Educational Resources Information Center

Simonis, Doris G.

Described is the Industrial Arts component of the Iowa Developed Energy Activity Sampler (IDEAS), a multidisciplinary energy education program designed for infusion into the curriculum of grades 7-12. Also included in the program are activity sets for Home Economics (SE 034 678), Language Arts (SE 034 680), Mathematics (SE 034 681), Science (SE…

The Spectral Energy Distributions of z ~ 8 Galaxies from the IRAC Ultra Deep Fields: Emission Lines, Stellar Masses, and Specific Star Formation Rates at 650 Myr

NASA Astrophysics Data System (ADS)

Labbé, I.; Oesch, P. A.; Bouwens, R. J.; Illingworth, G. D.; Magee, D.; González, V.; Carollo, C. M.; Franx, M.; Trenti, M.; van Dokkum, P. G.; Stiavelli, M.

2013-11-01

Using new ultradeep Spitzer/InfraRed Array Camera (IRAC) photometry from the IRAC Ultra Deep Field program, we investigate the stellar populations of a sample of 63 Y-dropout galaxy candidates at z ~ 8, only 650 Myr after the big bang. The sources are selected from HST/ACS+WFC3/IR data over the Hubble Ultra Deep Field (HUDF), two HUDF parallel fields, and wide area data over the CANDELS/GOODS-South. The new Spitzer/IRAC data increase the coverage in [3.6] and [4.5] to ~120h over the HUDF reaching depths of ~28 (AB,1σ). The improved depth and inclusion of brighter candidates result in direct >=3σ InfraRed Array Camera (IRAC) detections of 20/63 sources, of which 11/63 are detected at >=5σ. The average [3.6]-[4.5] colors of IRAC detected galaxies at z ~ 8 are markedly redder than those at z ~ 7, observed only 130 Myr later. The simplest explanation is that we witness strong rest-frame optical emission lines (in particular [O III] λλ4959, 5007 + Hβ) moving through the IRAC bandpasses with redshift. Assuming that the average rest-frame spectrum is the same at both z ~ 7 and z ~ 8 we estimate a rest-frame equivalent width of {W}_{[O\\,\\scriptsize{III}]\\ \\lambda \\lambda 4959,5007+H\\beta }=670^{+260}_{-170} Å contributing 0.56^{+0.16}_{-0.11} mag to the [4.5] filter at z ~ 8. The corresponding {W}_{H\\alpha }=430^{+160}_{-110} Å implies an average specific star formation rate of sSFR=11_{-5}^{+11} Gyr-1 and a stellar population age of 100_{-50}^{+100} Myr. Correcting the spectral energy distribution for the contribution of emission lines lowers the average best-fit stellar masses and mass-to-light ratios by ~3 ×, decreasing the integrated stellar mass density to \\rho ^*(z=8,M_{\\rm{UV}}<-18)=0.6^{+0.4}_{-0.3}\\times 10^6 \\,M_\\odot Mpc-3. Based on observations made with the NASA/ESA Hubble Space Telescope, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with programs #11563, 9797. Based on observations with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under NASA contract 1407. Support for this work was provided by NASA through contract 125790 issued by JPL/Caltech. Based on service mode observations collected at the European Southern Observatory, Paranal, Chile (ESO Program 073.A-0764A). Based on data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

Research Policy in the Federal Republic of Germany.

DTIC Science & Technology

1980-12-16

particularly for coal use, flue gas decontamination (particularly for desulfurization ), sewage treatment, biological pest control , and artificial fertilizers...NAME AND AODRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA 8 WORK UNIT NUMBERS 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE 16 December 198 0...34 1" NUMSER-OF PAGES 14. MONITORING AGENCY NAME & ADDRESS(If different fromt Controlling Office) 15. SECURITY CLASS. (o this repol) Unclassified

An animal model for the neuromodulation of neurogenic bladder dysfunction.

PubMed

Zvara, P; Sahi, S; Hassouna, M M

1998-08-01

To develop an animal model to examine the pathophysiology by which S3 sacral root electrostimulation alters the micturition reflex in patients with bladder hyper-reflexia. Chronic sacral nerve root electrostimulation was applied to spinally transected rats; 21 animals were divided into four groups. The spinal cord was completely transected at the T10-11 level and stainless-steel electrodes implanted into the sacral foramen in 17 animals; these animals were subsequently divided into two groups (1 and 2). Six rats in group 1 underwent sacral root elctrostimulation for 2 h/day and five in group 2 for 6 h/day, for 21 days. The sham group (group 3, six rats) received no stimulation and four rats were used as healthy controls (group 4). Voiding frequency was recorded and each animal was evaluated cystometrically at the end of the stimulation period. The results were compared with the sham and control groups. Spinal cord transection resulted in bladder areflexia and complete urinary retention; 7-9 days after the injury, the bladder recovered its activity. Twenty-one days after transection all animals had evidence of uninhibited bladder contractions. The mean (SD) hourly frequency of urination was 0.66 (0.18) in healthy controls, 0.83 (0.21) in group 1, 0.87 (0.34) in group 2 and 1.1 (0.31) in group 3. There was a significant decrease in eh cystometric signs of bladder hyper-reflexia in groups 1 and 2 when compared with group 3. This work reports and initial study showing that chronic electrostimulation of sacral nerve roots can reduce the signs of bladder hyper-reflexia in the spinally injured rat. To our knowledge, this is the first report describing the rat as an animal model to determine the effects of chronic electrostimulation on the micturition reflex.

Solid T-spline Construction from Boundary Triangulations with Arbitrary Genus Topology

DTIC Science & Technology

2012-04-01

Topology 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...Acknowledgements Y. Zhang, W. Wang and L. Liu were supported in part by ONR Grant N00014-08-1-0653. T. J.R. Hughes was sup- ported by ONR Grant N00014-08-1-0992, NSF...blue) and one pillowed layer (magenta); and (h) the isogeometric analysis result. 11 0700807/0700204, NSF CMMI-1101007 and a grant from SINTEF. The

25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

Code of Federal Regulations, 2013 CFR

2013-04-01

... contract payments; 7. Approving contract modifications; 8. Processing claims and disputes with tribal... assure compliance with or exceeding Federal standards for IRR design and construction. G. Construction: 1... inspection and acceptance of project documents as-built drawings on behalf of BIA as facility owner; and 11...

Long-term effects of substance P on the isolated guinea pig trachea.

PubMed

Schreiber, J; Slapke, J; Nieber, K; Oehme, P

1988-01-01

The undecapeptide substance P(SP) and its C-terminal sequence SP-5-11 induced a dose-dependent contraction of the isolated guinea pig trachea. SP-5-11 had a more potent bronchoconstrictive action than SP-1-11. The distal part of the isolated guinea pig trachea showed a greater reagibility to SP-5-11 than the proximal one. There was a continuous increase of the amplitude of the SP-1-11-induced contractions when the neuropeptide was added several times at one-hour intervals. Incubation with 10(-6) M SP-1-11 for 5 h reduced the reagibility of the isolated guinea pig trachea to acetylcholine.

Effect of intermittent eccentric contractions on symptoms of muscle microinjury.

PubMed

Teague, B N; Schwane, J A

1995-10-01

The purpose was to determine whether varying the duration of rest between contractions affects selected symptoms of eccentric contraction-induced skeletal muscle microinjury. Thirty-three women were assigned to three groups (N = 11). Each performed one bout of exercise with each arm involving 10 eccentric contractions of the elbow flexor muscles, lowering a load equaling 60% of maximal static force. One arm exercised continuously; the other exercised with rest periods of 15 s, 5 min, or 10 min between contractions, depending on the group. Preexercise and 0, 24, and 48 h postexercise, symptoms of microinjury in the elbow flexor muscles were assessed: soreness and changes in strength, resting elbow angle ("musculotendinous stiffness"), and arm girth ("swelling"). For all groups combined, 10 continuous contractions caused changes (P < 0.05) in all variables at every measurement time. For example, soreness ratings (0-10 scale) were 4.3 +/- 2.0 (24 h) and 4.3 +/- 2.1 (48 h) and strength was reduced 18% 0 h postexercise. Responses were similar with 15 s of rest between contractions. Although they were moderated, symptoms occurred even with 5 and 10 min of rest. With 10 min between contractions, soreness occurred (e.g., 2.4 +/- 1.5 [24 h]) and strength was 17% reduced 0 h postexercise. Results are most consistent with a mechanical cause of eccentric contraction-induced muscle microinjury, rather than a metabolic or other factor with a short recovery time, although involvement of the latter cannot be ruled out.

76 FR 53921 - Privacy Act of 1974; Department of Homeland Security ALL-034 Emergency Care Medical Records...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

..., and others performing or working on a contract, service, grant, cooperative agreement, or other... medical records, including psychological records, the decision to release directly to the individual, or...

76 FR 2706 - Notice of Extension of Concession Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

... Program, National Park Service, 1201 Eye Street, NW., 11th Floor, Washington, DC 20005, Telephone 202/513... Fork National Seashore. York. BLRI004-88 Virginia Peaks of Blue Ridge Parkway. Otter. BUIS001-06..., Commercial Services Program, National Park Service, 1201 Eye Street, NW., 11th Floor, Washington, DC 20005...

Synthesis of 2,3-dihydronaphtho[2,3-d][1,3]thiazole-4,9-diones and 2,3-dihydroanthra[2,3-d][1,3]thiazole-4,11-diones and novel ring contraction and fusion reaction of 3H-spiro[1,3-thiazole-2,1'-cyclohexanes] into 2,3,4,5-tetrahydro-1H-carbazole-6,11-diones

PubMed Central

Konstantinova, Lidia S; Lysov, Kirill A; Souvorova, Ljudmila I

2013-01-01

Summary Treatment of N-substituted 2-(methylamino)naphthoquinones 3 and -anthracene-1,4-diones 4 with S2Cl2 and DABCO in chlorobenzene gave the corresponding 2,3-dihydronaphtho[2,3-d][1,3]thiazole-4,9-diones 1 and 2,3-dihydroanthra[2,3-d][1,3]thiazole-4,11-diones 2 by triethylamine addition, in high to moderate yields. The DABCO replacement for N-ethyldiisopropylamine in the reaction of anthracene-1,4-diones 4 led unexpectedly to the corresponding 2-thioxo-2,3-dihydroanthra[2,3-d][1,3]thiazole-4,11-diones 10. The reaction of 3H-spiro[1,3-thiazole-2,1'-cyclohexanes] 1d, 2d with Et3N in chlorobenzene under reflux yielded 2,3,4,5-tetrahydro-1H-carbazole-6,11-diones 15, 16, i.e., ring contraction and fusion products. A plausible mechanism was proposed for the formation of the products. PMID:23616798

41 CFR 60-2.11 - Organizational profile.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Contracts OFFICE OF FEDERAL CONTRACT COMPLIANCE PROGRAMS, EQUAL EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR... establishment. It is one method contractors use to determine whether barriers to equal employment opportunity... that may assist in identifying organizational units where women or minorities are underrepresented or...

48 CFR 18.109 - Priorities and allocations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... defense, emergency preparedness, and energy programs and was established to facilitate rapid industrial mobilization in case of a national emergency. (See Subpart 11.6.) [73 FR 21785, Apr. 22, 2008] ... CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities 18.109...

Defense Contracting: Actions Needed to Explore Additional Opportunities to Gain Efficiencies in Acquiring Foreign Language Support

DTIC Science & Technology

2013-02-25

Directive 5160.41E, Defense Language Program . 10GAO-11-456. Page 5 GAO-13-251R Defense Contracting types of foreign language support that DOD has acquired...Language Transformation Roadmap, (January 2005), and Department of Defense Directive 5160.41E, Defense Language Program . Page 15 GAO-13-251R Defense...examines the use of public funds; evaluates federal programs and policies; and provides analyses, recommendations, and other assistance to help

Lanthanide contraction effect on crystal structures of lanthanide coordination polymers with cyclohexanocucurbit[6]uril ligand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Li-Mei; Liu, Jing-Xin, E-mail: jxliu411@ahut.edu.cn

A series of compounds based on the macrocyclic ligand cyclohexanocucurbit[6]uril (Cy6Q[6]) with formulas (Ln(H{sub 2}O){sub 6}Cy6Q[6])·2(CdCl{sub 4})·H{sub 3}O·xH{sub 2}O [isomorphous with Ln=La (1), Ce (2), Pr (3) and Nd (4), x=11 (1), 11 (2), 10 (3) and 11 (4)], (Sm(H{sub 2}O){sub 5}Cy6Q[6])·2(CdCl{sub 4})·H{sub 3}O·10H{sub 2}O (5) and (Ln(H{sub 2}O){sub 5}(NO{sub 3})@Cy6Q[6])·2(CdCl{sub 4})·2H{sub 3}O·xH{sub 2}O [isomorphous with Ln=Gd (6), Tb (7) and Dy (8), x=8 (6), 6 (7) and 6 (8)], have been successfully synthesized by the self-assembly of Cy6Q[6] with the corresponding lanthanide nitrate under hydrochloric acid aqueous solution in the presence of CdCl{sub 2}. Single-crystal X-ray diffraction analyses revealedmore » that compounds 1–8 all crystallize in monoclinic space group P2{sub 1}/c, and display 1D coordination polymer structures. The lanthanide contraction effect on the structures of 1–8 has also been investigated and discussed in detail. In contrast, the reaction of Cy6Q[6] with the Ho(NO){sub 3}, Tm(NO){sub 3}, Yb(NO){sub 3} under the same conditions resulted in the compounds 9–11 with formulas Cy6Q[6]·2(CdCl{sub 4})·2H{sub 3}O·xH{sub 2}O [isomorphous with x=10 (9), 10 (10), and 9 (11)], in which no lanthanide cations are observed. The structural difference of these compounds indicates that the Cy6Q[6] may be used in the separation of lanthanide cations. - Graphical abstract: The reaction of cyclohexanocucurbit[6]uril with lanthanide ions (La{sup 3+}, Ce{sup 3+}, Pr{sup 3+}, Nd{sup 3+}, Sm{sup 3+}, Gd{sup 3+}, Tb{sup 3+}, Dy{sup 3+}, Ho{sup 3+}, Tm{sup 3+} and Yb{sup 3+}) under hydrochloric acid in the presence of CdCl{sub 2} resulted in eleven compounds, which demonstrate interesting lanthanide contraction effect and provide a means of separating lanthanide ions. - Highlights: • Eleven compounds of the Ln{sup 3+} with the Cy6Q[6] were synthesized and described. • Compounds 1-8 demonstrate interesting lanthanide contraction effect. • In solid-state structures of compounds 9-11, no lanthanide ions were observed. • This study provides a means of separating lanthanides cations.« less

48 CFR 819.7009 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business..., Notice of Total Service-Disabled Veteran-Owned Small Business Set-Aside or 852.219-11, Notice of Total...

48 CFR 819.7009 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business..., Notice of Total Service-Disabled Veteran-Owned Small Business Set-Aside or 852.219-11, Notice of Total...

76 FR 24343 - Advanced Biofuel Payment Program; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

...-AA75 Advanced Biofuel Payment Program; Correction AGENCY: Rural Business-Cooperative Service; Rural... Federal Register of February 11, 2011, establishing the Advanced Biofuel Payment Program authorized under... this Program, the Agency will enter into contracts with advanced biofuel producers to pay such...

Regulatory Relief: Simplifying and Eliminating Contract Clauses. Volume 1

DTIC Science & Technology

1989-11-01

CA Mzu IG1z czt I, r= w1 2 E I cn 2 d Q A- O.jI I3 Ir c:I w0 10 00 0 14 0 0 0 rI- 0 u1 t8 0 - Iu "I IU -I U w .0I 1u I efl I ~ >I2I I ’.4 0 1~ 0"’ a)w...10 -4 ~ ~ 4I 1- I~~ ~ C) I O *r O I O 4) I C 1W-. af I24)I 0 11- I 10.1 0 10 1 .*( lwMIC . W t. 12 W - I rW I n 0 12 0 4)J~I 0" 0 C13 V0 01uO I 0 (14

Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991

DTIC Science & Technology

1991-01-01

u I (04q N -iLifLn-i0)00 .- Cl) -- If .’t- -- 400 r1I- -4-. M(𔄁 . "I XN 1,- 1I to I (04e 11 1f4.-400𔃾 in -f o~n InJ N L0304 toN 0n (no U O 4 vUN 0...o CN M C) a) "൒ -’ 14"to0" C>(W P 00(W0t- 00m 0- --4 C~nC’ r-- KooN 400 0 -4-4 a0(D0)( w 4(1(0 -4 * 4m( 0-4 m0000000CC>C0 -4"K 4OI 41 CC D>)- 000C

The Effect of Interchanging the Polarity of the Dense Plasma Focus on Neutron Yield

NASA Astrophysics Data System (ADS)

Jiang, Sheng; Higginson, Drew; Link, Anthony; Schmidt, Andrea

2017-10-01

The dense plasma focus (DPF) Z-pinch devices can serve as portable neutron sources when deuterium is used as the filling gas. DPF devices are normally operated with the inner electrode as the anode. It has been found that interchanging the polarity of the electrodes can cause orders of magnitude decrease in the neutron yield. Here we use the particle-in-cell (PIC) code LSP to model a DPF with both polarities. We have found the difference in the shape of the sheath, the voltage and current traces, and the electric and magnetic fields in the pinch region due to different polarities. A detailed comparison will be presented. Prepared by LLNL under Contract DE-AC52-07NA27344 and supported by the Laboratory Directed Research and Development Program (15-ERD-034) at LLNL. Computing support for this work came from the LLNL Institutional Computing Grand Challenge program.

7 CFR 634.11 - Availability of funds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Availability of funds. 634.11 Section 634.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.11 - Availability of funds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Availability of funds. 634.11 Section 634.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.11 - Availability of funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Availability of funds. 634.11 Section 634.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.11 - Availability of funds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Availability of funds. 634.11 Section 634.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

Novel Therapeutic Targets for Chronic Migraine

DTIC Science & Technology

2014-11-01

Award Number: W81XWH-11-1-0647 TITLE: Novel Therapeutic Targets for Chronic Migraine PRINCIPAL INVESTIGATORS: Peter Goadsby CONTRACTING...Therapeutic Targets for Chronic Migraine 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0647 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Peter Goadsby, M.D...ABSTRACT Chronic migraine is a disabling disorder that affects millions of individuals worldwide, and may result from traumatic brain injury. The purpose of

Novel Therapeutic Targets for Chronic Migraine

DTIC Science & Technology

2014-11-01

A D Award Number: W81XWH-11-1-0646 TITLE: Novel Therapeutic Targets for Chronic Migraine PRINCIPAL INVESTIGATORS: Andrew Charles CONTRACTING...for Chronic Migraine 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0646 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Andrew Charles, M.D. and Peter...Chronic migraine is a disabling disorder that affects millions of individuals worldwide, and may result from traumatic brain injury. The purpose of this

Defense Procurement: An Analysis of Contract Management Internal Controls

DTIC Science & Technology

2015-03-22

monitoring activities component of the internal control framework. Acquisition Research Program Graduate School of Business & Public Policy - 7...Research Program Graduate School of Business & Public Policy - 24 - Naval Postgraduate School Tan, L. H. J. (2013). An analysis of internal controls and...Naval Postgraduate School, Monterey, CA 93943. Defense Procurement: An Analysis of Contract Management Internal Controls 22 March 2015 Dr. Juanita

Crystal Growth Furnace (CGF)

NASA Technical Reports Server (NTRS)

Billingsley, Charles E.; Frederick, Larry

1993-01-01

The contract baseline, contract requirements review, contract modifications, contract problem areas and conclusions are addressed. Contract baseline was established 11 June 1987 and updated 1 December 1989. Significant changes were introduced into the 1989 baseline as compared to the original baseline. Contract modifications were made to add requirements as the program matured and as definition of requirements were completed. Problems were solved in real time through the contractor/customer team involvement and relationship to assure a timely and successful mission. The conclusion is that the CGF performed as designed and the experiments performed during the USML-1 Mission supports the conclusion.

Guidelines for Research Planning and Design in Task Analysis

DTIC Science & Technology

1975-09-01

Personnel and Training Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370...Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for public release...for ways in which the hypothesis can be tested . There are 11 several ways to do this and they are often used jointly. 1* Review of the Literature

Munitions Test Area and Incendiary Drop Site, Site 36-2, Data Addendum, Phase 2.

DTIC Science & Technology

1988-09-01

MUNITIONS TEST AREA AND INCENDIARY DROP SITE (NI September 1988 Contract Number DAAK11-84-D-0016 | • (Version 3.1) Environmental Science And Engineering, Inc...SITE, September 1988 Contract Number DAAK11-84-D-0016 (Version 3.1)I PREPARED BY ENVIRONMENTAL SCIENCE AND ENGINEERING, INC. Harding Lawson Associates I...the Program Managers Office (PMO). Environmental Science and Engineering (ESE), Morrison-Knudsen Engineers (MKE), and Harding Lawson Associates (HLA

7 CFR 636.11 - Transfer of interest in a cost-share agreement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Transfer of interest in a cost-share agreement. 636.11 Section 636.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.11 - Transfer of interest in a cost-share agreement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Transfer of interest in a cost-share agreement. 636.11 Section 636.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVES PROGRAM § 636...

7 CFR 636.11 - Transfer of interest in a cost-share agreement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Transfer of interest in a cost-share agreement. 636.11 Section 636.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.11 - Transfer of interest in a cost-share agreement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Transfer of interest in a cost-share agreement. 636.11 Section 636.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.11 - Transfer of interest in a cost-share agreement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Transfer of interest in a cost-share agreement. 636.11 Section 636.11 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

Modeling the Effects of Ecosystem Fragmentation and Restoration: Management Models for Mobile Animals

DTIC Science & Technology

2003-12-01

0.59 * 0.63 0.34 0.34 0.34 0.34 2001 ** * 0.37 0.14 0 0 0.07 Pholisorus catullus 2001 * 0.22 0.08 0.08 0.08 0.08 Pieris protodice 2001 * 0.25 0.75...0 2 2001 11 4 Liminitis archippus 2000 4 2 2001 8 7 Phoebis sennae 2000 3 3 0 3 2001 4 12 4 3 Pholisorus catullus 2001 0 7 Pieris protodice 2001 1 3 1...1999. The response of Colia eurytheme (Lepidoptera: Pieris ) and Neophasia menapia (Lepidoptera: Pieris ) to the structural edge created by

75 FR 71562 - Defense Federal Acquisition Regulation Supplement; Contract Authority for Advanced Component...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... Development or Prototype Units (DFARS Case 2009-D034) AGENCY: Defense Acquisition Regulations System... the procurement of prototype units. The DFARS implementation places specific limits, in accordance... components or the procurement of prototype units. IV. Paperwork Reduction Act The Paperwork Reduction Act...

Trajectory and Force Control of a Direct Drive Arm.

DTIC Science & Technology

1986-09-01

NUMBER 7. AUTNOn(s) . CONTRACT OR GRANT Ity൓"s ) Chae H. An N00014-80- C -- . O , 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT...and notations are used: 0 -W, WV CW { o ][:][ x] c (2.9) Wd X C -" W, 0 -W, cy -"X C (2) _-t V Wz 0 C , 11 󈧏 W, wy W, 0 0 0 112 112 W 0[ W. I0l (2.10) 0...theorem is used to compute the inertia terms translated to the center of mass of the load. C (2.16) )M Ji = P1- tn[(#TE)l -- (ZT)] (2.17) Then, the

78 FR 46365 - Quarterly Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... Stream Commission O&M Operation and Maintenance P-SMBP Pick-Sloan Missouri Basin Program PPR Present... stored water from Applegate Reservoir (a USACE project) for irrigation use in exchange for the transfer... of Oregon for instream flow use. Completed contract action: 11. Prineville Reservoir Water Users...

75 FR 10645 - Low Pathogenic Avian Influenza; Voluntary Control Program and Payment of Indemnity

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

...We are adopting as a final rule, with changes, an interim rule that amended the regulations by establishing, under the auspices of the National Poultry Improvement Plan, a voluntary program for the control of the H5/H7 subtypes of low pathogenic avian influenza in commercial poultry. As amended by this document, the rule provides that the amount of indemnity for which contract growers are eligible will be reduced by any payment they have already received on their contracts when poultry in their care are destroyed, clarifies the roles of cooperating State agencies with respect to H5/H7 low pathogenic avian influenza outbreaks, provides that consistency with humane euthanasia guidelines will be considered when selecting a method for the destruction of poultry, and provides additional guidance for cleaning and disinfecting an affected premises. The control program and indemnity provisions established by the interim rule are necessary to help ensure that the H5/H7 subtypes of low pathogenic avian influenza are detected and eradicated when they occur within the United States.

Specification Section 01065S ES&H for Service Contracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirsch, Greg C.

2014-07-01

Section Includes: Requirements and guidelines in performance of work concerning protection of environment and property, and the safety and health of Contractors, Sandia National Laboratories (SNL) and Department of Energy (DOE) employees, visitors to SNL, and members of the public. This Section is applicable only to Service Contracts that do not involve construction or construction-like activities. Construction and construction-like activities are covered by Section 01065, Environment, Safety and Health (ES&H) for Construction Contracts. The entire ES&H program shall focus on safe-by-design intent, understanding the technical basis for the work, identifying and controlling energy sources, unacceptable consequences, risk assessments, and positivemore » verification.« less

Prime Contract Awards of $100,000 or More by Federal Supply Classification or Service Category and Purchasing Office. Part 2 (5450-9999)

DTIC Science & Technology

1989-01-01

af a>o - o CL -4 0-u< m - CLO. -4 0 WC -4 M b c CLC 0 )U"aCV C 0L > 4 .t 0 0L 0 " .0." ID0ZW W4 .0 04q 4- I- H 00CL1 0 CC, 0U) 0L >-1 ~3 CL EU ) ɜ...E0 0 E E U a 4-43H ~ U 0 MO 000 af ) H) o 00W 00 0 U) 0 00000 0 w -J f-L U- 0’ O () 00 a) Z -J cl -4 0) -1 (n <-0 40 0 -j -4 4 -l000-4 000N1 -AC 4- -4 L...uL )L)U :fL- _ L CLO CL𔃾--- CL C - 0. L1- - LUUC C CA oO0ooCL -. Cl0 C-. Ovcn0 WUC -j L0_0 $1 >L)0 U -4 Ec - 0)( ( o( af 0. CL M 2u )(1) L c ) L L

A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro.

PubMed

Battistini, B; Filep, J G; Cragoe, E J; Fournier, A; Sirois, P

1991-03-15

Endothelin-1-induced contractions of guinea pig tracheal and bronchial strips were dose-dependently attenuated by the amiloride analogues 5-(N-ethyl-N-isopropyl)amiloride (EIPA, 1-10 microM) and 5-(N,N-hexamethylene)amiloride (HMA, 1-10 microM). The calculated Ki values for EIPA and HMA were 0.11 +/- 0.02 microM and 0.06 +/- 0.02 microM in the trachea, and 0.28 +/- 0.11 microM and 0.70 +/- 0.25 microM in the bronchus, respectively. These values are in the same order of magnitude as those reported for inhibition of the Na+/H+ exchange in cells. Amiloride (1-10 microM) was ineffective. These data suggest that activation of the Na+/H+ exchange by ET-1 may be involved in mediating its myotropic action in guinea pig airway smooth muscle.

41 CFR 105-8.170-11 - Hearing.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Hearing. 105-8.170-11... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.170-11 Hearing. (a) Upon a timely request for a hearing, the Special Counsel shall take the necessary action to obtain the...

41 CFR 105-8.170-11 - Hearing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Hearing. 105-8.170-11... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.170-11 Hearing. (a) Upon a timely request for a hearing, the Special Counsel shall take the necessary action to obtain the...

41 CFR 105-8.170-11 - Hearing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Hearing. 105-8.170-11... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.170-11 Hearing. (a) Upon a timely request for a hearing, the Special Counsel shall take the necessary action to obtain the...

42 CFR 68a.11 - How does an individual receive loan repayments beyond the initial two-year contract?

Code of Federal Regulations, 2010 CFR

2010-10-01

...) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.11... debt remaining to be repaid and the individual is engaged in approved clinical research as an NIH...

42 CFR 68c.11 - How does an individual receive loan repayments beyond the initial two-year contract?

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY RESEARCH LOAN REPAYMENT PROGRAM § 68c.11 How does... remaining to be repaid and the individual is engaged in research on infertility or contraceptive development...

42 CFR 68c.11 - How does an individual receive loan repayments beyond the initial two-year contract?

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY RESEARCH LOAN REPAYMENT PROGRAM § 68c.11 How does... remaining to be repaid and the individual is engaged in research on infertility or contraceptive development...

Program on the combustion chemistry of low- and intermediate-Btu gas mixtures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-11-30

Low and intermediate Btu (LBTU and IBTU) gas mixtures are essentially mixtures of CO, H/sub 2/ and CH/sub 4/ diluted with nitrogen and CO/sub 2/. Although the combustion properties of these three fuels have been extensively investigated and their individual combustion kinetics are reasonably well established, prediction techniques for applying these gas mixtures remain for the most part empirical. This program has aimed to bring together and apply some of the fundamental combustion parameters to the CO-H/sub 2/-CH/sub 4/ flame system with the hope of reducing some of this empiricism. Four topical reports have resulted from this program. This finalmore » report summarizes these reports and other activities undertaken in this program. This program was initiated June 22, 1976 under ERDA Contract No. E(49-18)-2406 and was later continued under DOE/PETC and DOE Contract No. DE-AC22-76ET10653.« less

10 CFR 961.11 - Text of the contract.

Code of Federal Regulations, 2014 CFR

2014-01-01

... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

10 CFR 961.11 - Text of the contract.

Code of Federal Regulations, 2013 CFR

2013-01-01

... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

Electronic Joint Army/Navy Point Detonating/Delay Fuze

DTIC Science & Technology

1982-08-01

be battery powered and will use an existing S & A , such as an M739 . We recormiended that the fuzes be fired at various zones and high-speed cameras...Demonstrator 10 Power Supply Tasks 47 11 Electronic S & A 43 11.1 Explosive Barrier Module 49 11.2 Internal Development Program 51 12 Fuze Packaging...program, contract number DAAK10-80-C-0049. We included the Electronic S & A and Fuze Packaging sections to present a complete understanding of the overall

Job Order Contracting: A Procurement Success Story

DTIC Science & Technology

1988-02-01

Engineering/Procurement processing time 279 CI4 TABLE C-2 JOC DELIVERY ORDER PROCESSING TIME Contract size and location Amount Elapsed time- ($000) days...Bragg 2.1 68 Monroe 2.1 196 Sill 2.2 3 bragg 2.3 32 C-5 Ii ~A¶A~.AL&A .LiA..hLI TABLE C-2 JOC DELIVERY ORDER PROCESSING TIME (Continued) Conrat szean...DEUVERY ORDER PROCESSING TIME (Continued) Amount Elapsed time- Contract size and location Amou daps($000) days Bragg S 14.7 11 Monroe 14.8 30 Monroe

Germanium, Arsenic, and Selenium Abundances in Metal-poor Stars

NASA Astrophysics Data System (ADS)

Roederer, Ian U.

2012-09-01

The elements germanium (Ge, Z = 32), arsenic (As, Z = 33), and selenium (Se, Z = 34) span the transition from charged-particle or explosive synthesis of the iron-group elements to neutron-capture synthesis of heavier elements. Among these three elements, only the chemical evolution of germanium has been studied previously. Here we use archive observations made with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope and observations from several ground-based facilities to study the chemical enrichment histories of seven stars with metallicities -2.6 <= [Fe/H] <= -0.4. We perform a standard abundance analysis of germanium, arsenic, selenium, and several other elements produced by neutron-capture reactions. When combined with previous derivations of germanium abundances in metal-poor stars, our sample reveals an increase in the [Ge/Fe] ratios at higher metallicities. This could mark the onset of the weak s-process contribution to germanium. In contrast, the [As/Fe] and [Se/Fe] ratios remain roughly constant. These data do not directly indicate the origin of germanium, arsenic, and selenium at low metallicity, but they suggest that the weak and main components of the s-process are not likely sources. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. This research made use of StarCAT, hosted by the Mikulski Archive at the Space Telescope Science Institute (MAST). These data are associated with Programs GO-7348, GO-7433, GO-8197, GO-9048, GO-9455, and GO-9804.Based on data obtained from the European Southern Observatory (ESO) Science Archive Facility. These data are associated with Programs 67.D-0439(A), 074.C-0364(A), 076.B-0055(A), and 080.D-0347(A).This research has made use of the Keck Observatory Archive (KOA), which is operated by the W.M. Keck Observatory and the NASA Exoplanet Science Institute (NExScI), under contract with the National Aeronautics and Space Administration. These data are associated with Programs H2aH, H6aH, and H39aH (PI: Boesgaard), N01H (PI: Latham), and U11H (PI: Prochaska).This paper includes data taken at The McDonald Observatory of The University of Texas at Austin.

Development of Graphical Pole-Zero, Root-Locus, Bode, Nyquist, and Nichols Responses Using the OPTSYSX Program.

DTIC Science & Technology

1984-09-01

JV) 0..J- 11- 0.7 it HIZ-z7WaWI 1-I 1 1- I"c 9-4... It-)% -Q-0 .) 15 1 ’-0 -a -aI w Lo I U .. J()V) .40%. 11 UL)(S)Cg’ 11 VOZ - - ’-0 1 ’-I U). 0...34- 9-4W s-XW-XJ) 11 W 04- 11 .J I LVLOL- G*Z- 1 1" I -SI . . . . . .4 1 11I ZNJ’-..i9-- XI-%WtDo N DLD1-slC T 0 z(~zt)->I I V-1 PIŕ IP OH Zj .-I- 0...ut) WWCD U󈧎-,-o,- 0 L,4-u4,44u4-- ut 1 i I4j<=wa: a.) m- ip -, wnJ 11111> .60o .0 - 1 Wl -to -W l .J11 lii 11 1111 Z"’")i 1~~:...cIV..L UIZIn-’Z F

Global Network Connectivity Assessment via Local Data Exchange for Underwater Acoustic Sensor Networks

DTIC Science & Technology

2014-03-31

Network Connectivity Assessment via Local Data Exchange for Underwater Acoustic Sensor Networks M.M. Asadi H. Mahboubi A...2014 Global Network Connectivity Assessment via Local Data Exchange for Underwater Acoustic Sensor Networks Contract Report # AMBUSH.1.1 Contract...pi j /= 0. The sensor network considered in this work is composed of underwater sensors , which use acoustic waves for

Women show similar central and peripheral fatigue to men after half-marathon.

PubMed

Boccia, Gennaro; Dardanello, Davide; Tarperi, Cantor; Festa, Luca; La Torre, Antonio; Pellegrini, Barbara; Schena, Federico; Rainoldi, Alberto

2018-06-01

Women are known to be less fatigable than men in single-joint exercises, but fatigue induced by running has not been well understood. Here we investigated sex differences in central and peripheral fatigue and in rate of force development (RFD) in the knee extensors after a half-marathon run. Ten male and eight female amateur runners (aged 25-50 years) were evaluated before and immediately after a half-marathon race. Knee extensors forces were obtained under voluntary and electrically evoked isometric contractions. Maximal voluntary isometric contraction (MVC) force and peak RFD were recorded. Electrically doublet stimuli were delivered during the MVC and at rest to calculate the level of voluntary activation and the resting doublet twitch. After the race, decreases in MVC force (males: -11%, effect size [ES] 0.52; females: -11% ES 0.33), voluntary activation (males: -6%, ES 0.87; females: -4%, ES 0.72), and resting doublet twitch (males: -6%, ES 0.34; females: -8%, ES 0.30) were found to be similar between males and females. The decrease in peak RFD was found to be similar between males and females (males: -14%, ES 0.43; females: -15%, ES 0.14). Half-marathon run induced both central and peripheral fatigue, without any difference between men and women. The maximal and explosive strength loss was found similar between sexes. Together, these findings do not support the need of sex-specific training interventions to increase the tolerance to neuromuscular fatigue in half-marathoners.

48 CFR 11.601 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... promote the national defense by the Secretary of Defense, the Secretary of Energy, or the Secretary of Homeland Security, under the authority of the Defense Production Act, the Stafford Act, and Executive Order... ratings on contracts or orders needed to support approved programs. National defense means programs for...

10 CFR 961.11 - Text of the contract.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requires permanent isolation. 13. The term electricity (kilowatt hours) generated and sold means gross...-type documents or computer software (including computer programs, computer software data bases, and...

Yacht type and crew-specific differences in anthropometric, aerobic capacity, and muscle strength parameters among international Olympic class sailors.

PubMed

Bojsen-Møller, Jens; Larsson, Benny; Magnusson, S Peter; Aagaard, Per

2007-08-01

Physical fitness and muscular strength are important performance factors for Olympic class sailors, but the physical demands vary greatly between yacht classes, and limited information is available regarding the physical demands for the different crew positions. In the present paper, strength and aerobic capacity data from elite Olympic sailors are presented and compared with previous findings. Furthermore, a system for classification of Olympic class sailors is suggested. Peak aerobic capacity (peak oxygen uptake, VO(2peak)) and maximal isometric and isokinetic muscle strength of the knee extensors and flexors were assessed, together with the hamstring/quadriceps strength ratio (H/Q ratio). Peak aerobic capacity (ml O(2) . min(-1) . kg(-2/3)) was as follows: males - static hikers (n = 5) 215, s = 7; dynamic hikers (n = 8) 252, s = 17; trapezing helmsmen (n = 6) 234, s = 15; trapezing crew (n = 10) 239, s = 16; females - dynamic hikers (n = 6) 194, s = 16; trapezing crew (n = 2) 200, s = 13. Strength data for hikers, presented as peak moments (normalized to body weight) obtained during eccentric, isometric, and concentric contraction (Nm . kg(-1)) respectively were as follows: males - quadriceps: 3.66 (s = 0.68), 3.97 (s = 0.66), 1.82 (s = 0.34); hamstrings: 1.93 (s = 0.22), 1.38 (s = 0.41), 1.05 (s = 0.21); females - quadriceps: 3.84 (s = 0.71), 3.81 (s = 0.58), 1.60 (s = 0.28); hamstrings: 1.75 (s = 0.23), 1.10 (s = 0.16), 0.84 (s = 0.13). The peak moment based H/Q ratios for slow eccentric and concentric contractions were 0.42 (s = 0.11) and 0.39 (s = 0.04) for males and 0.43 (s = 0.06) and 0.39 (s = 0.04) for females respectively. Elite Olympic class sailors demonstrated high VO(2peak) values comparable to those observed in other non-endurance sports. The strength data revealed very high quadriceps strength for hikers, which is likely a result of the high muscle forces encountered during sailing, and a low H/Q ratio. To ensure optimal knee joint stabilization during sailing and other training activities, it is suggested that hikers should counter this strength imbalance by performing additional strength training for the hamstrings muscle group.

Means of Effective Security Sector Reform: A Comparison of US Military and Contractor Programs

DTIC Science & Technology

2011-05-19

the US Army took over 400 suspension / debarment actions in fiscal year 2010.65 GAO report 11-419T, Foreign Operations: Key Issues for Congressional...Contracting, Ensuring Contractor Accountability: Past Performance and Suspension & Debartment, Testimony, (Washington, D.C.: Commission on Wartime...64 Ibid., 8. 65 Commission on Wartime Contracting, Ensuring Contractor Accountability: Past Performance and Suspension

Final Closeout Report University Research Program in Robotics for Environmental Restoration and Waste Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

James S. Tulenko; Carl Crane

2004-08-24

The report covers the 2003-04 contract period, with a retrospective of the 11 years for the contract, from 1993 to 2004. This includes personnel, technical publications and reports, plus research laboratories employed. Specific information is given in eight research areas, reporting on all technology developed and/or deployed by the University of Florida.

Re-Evaluation of the Lower San Fernando Dam. Report 3. The Behavior of Undrained Contractive Sand and Its Effect on Seismic Liquefaction Flow Failures of Earth Structures

DTIC Science & Technology

1989-09-01

34 nrn. 4th World Crnf. n 7rthquake Engr., Vol 2, Santiago , Chile , pp. 1-11. 137. Seed, H.B., Lee, K.L. and Idriss, I.M. (1969): "An Analysis of...391 Fig. 8.10. Approximate Sections Through Large Slide Area Near Lake Rinihue, Chile (after Seed, 1967) . . . 392 Fig. 8.11. Cross Section of...to clarify the fundamental behavior of these soils. Previous work on contractive sands concentrated on steady-state or residual strength

Bibliography of In-House and Contract Reports, Supplement 11 and Index for 1970-1983.

DTIC Science & Technology

1983-03-01

1980 36 Stiles , W. H. 1981 16 Stilwell, J. E . 1971 3 Stockman, G. C. 1979 40 1982 3,6,13 Stockwell, G. N. 1971 5 1978 37 Stoll, A. W. 1971 14 Stone, J...NATIONAL BUREAU OF STANDARDS. 1963 A 10 * o * e ; 000000* ETL-0320 Bibliography of in-house and contract reports, Ssupplement 11 and index for 1970 - 1983...19. KEY WORDS (Continu~ e on rev’erse eide It necessary end Identify by block number) *20. A8SrR ACT r~mrtoe sit reverse afell if necveawy end Idenlitly

75 FR 432 - Notice of Extension of Concession Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... Service, 1201 Eye Street, NW., 11th Floor, Washington, DC, 20005, Telephone 202/513-7156. SUMMARY... Park, Inc..... Biscayne National Park. BLRI004-88 Virginia Peaks of Otter Blue Ridge Parkway. EVER004... Services Program, National Park Service, 1201 Eye Street, NW., 11th Floor, Washington, DC 20005, Telephone...

Air Force Operational Medicine: Using the Enterprise Estimating Supplies Program to Develop Materiel Solutions for the Operational Requirements of the Air Force Otorhinolaryngology Augmentation Team (FFENT)

DTIC Science & Technology

2010-10-11

6515NCM040920 MONITOR NERVE INTEGRITY RESPOSE 2.0 EA 1 0 0.1 0.1 25500 0 0 0 A 6515014975058 MONOCULAR ASSISTANT PACKAGE WELSH EA 2 2 2 0.03 4200 2 0.03...6515001817404 NEEDLE HYPO DENTAL 25GA SELF -THREAD 100S PG 1 0 0.75 0.034 8.12 0 0 0 D 6515015261730 NEEDLE HYPO GP 25GA X1IN SAFETY SHIELD 50S PG 2 0 11.1

Small Business Innovation Research (SBIR) Program. FY 1991 Program Solicitation 91.2

DTIC Science & Technology

1991-07-01

Based Robotic Control Systems Technology A91-034 Passive Sensor Self- Interference Cancellation A91-035 High Performance Propelling Charges A91-036...laboratory tests. A91-034 TITLE: Passive Sensor Self- Interference Cancellation CATEGORY: Exploratory Development OBJECTIVE: Develop practical and effective...acoustic sensor to detect, classify, identify, and locate targets is ARMY 19 degraded by own-platform noise and local interference . Elementary

Bioequivalence of clavulanate potassium and amoxicillin (1:7) dispersible tablets in healthy volunteers.

PubMed

Hu, Guoxin; Dai, Zongshun; Long, Lihong; Han, Ying; Hou, Shuxian; Wu, Li

2002-01-01

To study the bioequivalence of Clavulanate Potassium and Amoxicillin (1:7) dispersible tablets, a randomized cross-over study was conducted in 18 healthy volunteers. A single oral dose of 1,000 mg Clavulanate Potassium and Amoxicillin (1:7) dispersible tablets (Tested formulation, T) or Augmentin syrup (Reference formulation, R). Concentrations in plasma were determined with high-performance liquid chromatography. The main parameters of T were: for Clavulanate Potassium and Amoxicillin, Cmax: 2.46 +/- 1.11 micrograms/ml and 18.81 +/- 7.26 micrograms/ml, Tmax: 1.12 +/- 0.23 h and 1.30 +/- 0.34 h, AUC(0-6 h): 5.18 +/- 2.24 micrograms.h/ml and 45.09 +/- 14.53 micrograms.h/ml, t1/2: 1.43 +/- 0.44 h and 1.09 +/- 0.22 h., respectively. The relative bioavailability of T to R were 96.5 +/- 19.2% and 98.4 +/- 26.1%, respectively. Statistical analysis showed that the two formulations were bioequivalent.

Implementation of the Air Program Information Management System (APIMS) Inspection Module

DTIC Science & Technology

2009-05-01

7 5 T H A I R B A S E W I N G Implementation of the Air Program Information Management System (APIMS) Inspection Module 2009 Environment...Implementation of the Air Program Information Management System (APIMS) Inspection Module 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER

48 CFR 301.270 - Executive Committee for Acquisition.

Code of Federal Regulations, 2012 CFR

2012-10-01

...). (10) Program Support Center (PSC). (11) Substance Abuse and Mental Health Services Administration..., Contracts and Grants (ASPR/OAMCG). (4) Centers for Disease Control and Prevention (CDC). (5) Centers for...

48 CFR 301.270 - Executive Committee for Acquisition.

Code of Federal Regulations, 2014 CFR

2014-10-01

...). (10) Program Support Center (PSC). (11) Substance Abuse and Mental Health Services Administration..., Contracts and Grants (ASPR/OAMCG). (4) Centers for Disease Control and Prevention (CDC). (5) Centers for...

48 CFR 301.270 - Executive Committee for Acquisition.

Code of Federal Regulations, 2013 CFR

2013-10-01

...). (10) Program Support Center (PSC). (11) Substance Abuse and Mental Health Services Administration..., Contracts and Grants (ASPR/OAMCG). (4) Centers for Disease Control and Prevention (CDC). (5) Centers for...

Expeditionair Geneeskundige Uitrustingen. De Conceptmethode Toegepast op de Mercedes Benz Ziekenauto (Expeditionary Medical Kits. The Concept Method Applied to the Mercedes Benz Ambulance)

DTIC Science & Technology

2007-02-01

Wtar D.S. Gerretse 6/8 Projectbegeleider Defensie Centraal Militair Hospitaal t.a.v. kol. M.L. Vervelde 9 / 11 Bibliotheek KMA 12/13 Programmaleider TNO...Research Kampweg 5 Postbus 23 3769 ZG Soesterberg TNO-rapport wwton T 034 635 62 11 TNO-DV 2006 A487 F 034 635 39 77 info-DenV@tnonI Expeditionair...verschillende gebruikerssessies met AMV’ers en Probleernstelfing Dit heefi gevolgen voor de medische chauffeur/gewondenverzorgers is de nicuwe Het inzetprofiel

Confidence Region for the Evaluation of HF DF Single Site Location Systems.

DTIC Science & Technology

1983-09-02

CONTRACT ORt GRANT NUMBER(@) M.H. Reilly and J. Coran S. PERFORMING ORGANIZATION NAME AND ADDRESS WD PROGRAM ELEMENT. PROJECTAS Naval Research...1 DETERMINATION OF THE CONFIDENCE REGION....................2 COMPUTER PROGRAM FOR THE CONFIDENCE ELLIPSE..............5 EXAMPLES OF COMPUTER... PROGRAM OUTPUT......................6 DISCUSSION ................................................... 7 ACKNOWLEDGMENTS

Gas turbine engines and transmissions for bus demonstration program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nigro, D.N.

1981-11-01

This final report is to fulfill the contractural requirements of Contract DE-AC02-78CS54867 which required the delivery of 11 Allison GT 404-4 Industrial Gas Turbine Engines and five HT740CT and six V730CT Allison Automatic Transmissions for the Greyhound and Transit Coaches, respectively. In addition, software items such as cost reports, technical reports, installation drawings, acceptance test data and parts lists were required. Engine and transmission deliveries were completed with shipment of the last power package on 11 April 1980. Software items were submitted when required during the performance period of this contract.

Rothe Development Corporation v. Department of Defense: The Constitutionality of Federal Contracting Programs for Minority-Owned and Other Small Businesses

DTIC Science & Technology

2009-04-14

and analyzes Rothe’s potential effect on these programs, including the Business Development Program under Section 8(a) of the Small Business Act...13 Potential Vulnerability of Existing Programs... Newell , Decision in Defense Procurement Case Could Set Precedent, GovExec.com, Nov. 11, 2008, available at http://www.govexec.com/dailyfed/1108

77 FR 58424 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... Priority Customer complex orders that they send to the Exchange in these symbols. In the Select Symbols, the Exchange currently provides a base rebate of $0.34 per contract, per leg, for Priority Customer complex orders when these orders trade with non-Priority Customer complex orders in the complex order book...

Effect of prolonged general anesthesia with sevoflurane and laparoscopic surgery on gastric and small bowel propulsive motility and pH in dogs.

PubMed

Boscan, Pedro; Cochran, Shannon; Monnet, Eric; Webb, Craig; Twedt, David

2014-01-01

To determine if general anesthesia with sevoflurane and laparoscopic surgery changed gastric and small bowel propulsive motility or pH in dogs. Prospective, controlled trial. Twelve, 19-24 months old, female, Treeing Walker Hound dogs, weighing 23-30 kg. Dogs were anesthetized for a median of 8.5 hours during another study to determine the minimum alveolar concentration of sevoflurane using a visceral stimulus. Gastric and small bowel motility were determined using a sensor capsule that measures pressure, pH and temperature. Gastric transit time and motility index were calculated. For 8/12 dogs, gastric motility, pH and transit time were measured. In 4/12 dogs, small bowel motility and pH were measured. Anesthesia decreased gastric and small bowel motility but did not change luminal pH. Mean gastric contraction force decreased from median (range) 11 (8-20) to 3 (1-10) mmHg (p < 0.01) and gastric motility index decreased from 0.63 (0-1.58) to 0 (0-0.31; p = 0.01). Frequency of contractions did not change, 3.7 (1.6-4.4) versus 2.8 (0.1-5.1) contractions minute(-1) (p = 0.1). Gastric motility returned to normal 12-15 hours following anesthesia. Gastric emptying was prolonged from 12 (5.3-16) to 49 (9.75-56.25) hours (p < 0.01). Mean small bowel contraction force decreased from 34 (24-37) to 3 (0.9-17) mmHg (p < 0.02) and motility index decreased from 3.75 (1-4.56) to 0 (0-1.53; p = 0.02). Frequency of contractions did not change, 0.5 (0.3-1.4) versus 1.4 (0.3-4.6) contractions minute(-1) (p = 0.11). Small bowel motility returned within 2 hours after anesthesia. Laparoscopy did not result in changes to gastric or small bowel parameters beyond those produced by general anesthesia. The force of gastric and small bowel contractions decreased during sevoflurane anesthesia for laparoscopy. Although gastric motility returned to normal within 12-15 hours the impairment of gastric emptying lasted 30-40 hours, predisposing dogs to postoperative ileus. © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Mammalian Toxicological Evaluation of DIMP and DCPD. Phase 2

DTIC Science & Technology

1980-03-01

0r Daa r DaC ) -Cý C D C) 0 C) (n 0 0) %.C u 0 U Q CL Waa I- 41-1 .. ) D C 0 CU-ICj CD c ) &W 0" U ) C3 00 (.) 0 :I.- IU)L ODW w CZ -.jL r.c CD0 CO...AU 06. HO - 7-. -En -7ZL. .ZO.50 0 0 C% r- C00 M. H H a rNH CD ) (D r- Cjc 03 C H H CJ cqH *H tNNNN’ 1. 1 . 00O-1 N;6c*rý - +1 0-0 rt%% al c0C +1 +1+1...Zu w U) 0. Nr tvmvW4 tO r D- , C U-U U- 0nmC ’m A I0* i -6. I- -O! CJC - 0 U V0 cuD 0 S ul. m >0. mD 0.0 IC-D, ~ ...I 0.o ,r . lr TO-W-f. f 0ro coN *o

TNT Equivalency Testing of Chemical Mixtures in Continuous TNT Manufacturing

DTIC Science & Technology

1980-08-01

RONALD RAPE JOSEPH MAVEC RICHARD JOYCE IIT RESEARCH INSTITUTE 10 WEST35TH STREET CHICAGO. IL 60616 PAUL PRICE. PROJECT LEADER ARRADCOM. DOVER. NEW...AUTHORfs; Ronald Pape, Joseph Mavec, Richard Joyce, IIT Research Institute Paul Price, Project Leader, ARRADCOM 8. CONTRACT OR GRANT NUMBERfs...r-4 (0 ^ o s •H ^ <U XI 4J C-H •r4 1-1 i-l 1-1 >. a; X) U to •rl U «c U-l o 60 C *J •H C x m^: •^ E c B 4J CC M 4-J 4-1

Protons act as a transmitter for muscle contraction in C. elegans.

PubMed

Beg, Asim A; Ernstrom, Glen G; Nix, Paola; Davis, M Wayne; Jorgensen, Erik M

2008-01-11

Muscle contraction is normally mediated by the release of neurotransmitters from motor neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to stimulate muscle contraction. During the C. elegans defecation motor program the posterior body muscles contract even in the absence of neuronal inputs or vesicular neurotransmission. In this study, we demonstrate that the space between the intestine and the muscle is acidified just prior to muscle contraction and that the release of caged protons is sufficient to induce muscle contraction. PBO-4 is a putative Na+/H+ ion exchanger expressed on the basolateral membrane of the intestine, juxtaposed to the posterior body muscles. In pbo-4 mutants the extracellular space is not acidified and the muscles fail to contract. The pbo-5 and pbo-6 genes encode subunits of a "cys-loop" proton-gated cation channel required for muscles to respond to acidification. In heterologous expression assays the PBO receptor is half-maximally activated at a pH of 6.8. The identification of the mechanisms for release and reception of proton signals establishes a highly unusual mechanism for intercellular communication.

48 CFR 11.601 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... et seq.) and critical infrastructure protection and restoration. (50 U.S.C. App. § 2152). Rated order means a prime contract, a subcontract, or a purchase order in support of an approved program issued in...

48 CFR 11.601 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... et seq.) and critical infrastructure protection and restoration. (50 U.S.C. App. § 2152). Rated order means a prime contract, a subcontract, or a purchase order in support of an approved program issued in...

d-Neighborhood system and generalized F-contraction in dislocated metric space.

PubMed

Kumari, P Sumati; Zoto, Kastriot; Panthi, Dinesh

2015-01-01

This paper, gives an answer for the Question 1.1 posed by Hitzler (Generalized metrics and topology in logic programming semantics, 2001) by means of "Topological aspects of d-metric space with d-neighborhood system". We have investigated the topological aspects of a d-neighborhood system obtained from dislocated metric space (simply d-metric space) which has got useful applications in the semantic analysis of logic programming. Further more we have generalized the notion of F-contraction in the view of d-metric spaces and investigated the uniqueness of fixed point and coincidence point of such mappings.

Total Control: How the Nazis Countered Unconventional Warfare in the Netherlands During World War Two

DTIC Science & Technology

2017-05-25

rm) Command nml General Staff Colkgc ut any 1l1hcr go\\cmmcnt agc11c) (Rcl’crcm:cs lo 1h1s s111d) -.hould incllu.k the foregoing ~ lutcmcnt , ) h1ir...4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER I owl Co111rul. I lo \\\\ lhl’ Nu11s Counll’rccJ Unconvcnt1onul Wurlnrc in the dherlund~ Durmg World \\1 nr I...German population control wor"-cd best when 11 was lcn\\t inva:.ivc /\\. police opcrm ion ensured the dcs1ruc11on ot’ an Ang lo -Outd1 unconvcnllonal

Research of Ionospheric Scintillation in Asia (RISA)

DTIC Science & Technology

2014-03-01

5a. CONTRACT NUMBER FA2386-11-1-4087 5b. GRANT NUMBER Grant AOARD-114087 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Dr Nitin...11-1-4087 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Nitin Kumar Tripathi 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...anomaly, as these locations experience the strongest global levels of scintillation (Groves et al., 1997). As a result, large quantities of data sets

Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle.

PubMed

Kitazawa, Takio; Hirama, Ryuichi; Masunaga, Kozue; Nakamura, Tatsuro; Asakawa, Koichi; Cao, Jinshan; Teraoka, Hiroki; Unno, Toshihiro; Komori, Sei-ichi; Yamada, Masahisa; Wess, Jürgen; Taneike, Tetsuro

2008-06-01

Functional muscarinic acetylcholine receptors present in the mouse uterus were characterized by pharmacological and molecular biological studies using control (DDY and wild-type) mice, muscarinic M2 or M3 single receptor knockout (M2KO, M3KO), and M2 and M3 receptor double knockout mice (M2/M3KO). Carbachol (10 nM-100 microM) increased muscle tonus and phasic contractile activity of uterine strips of control mice in a concentration-dependent manner. The maximum carbachol-induced contractions (Emax) differed between cervical and ovarian regions of the uterus. The stage of the estrous cycle had no significant effect on carbachol concentration-response relationships. Tetrodotoxin did not decrease carbachol-induced contractions, but the muscarinic receptor antagonists (11-[[2-[(diethylaminomethyl)-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b[2,3-b][1,4]benzodiazepin6-one (AF-DX116), N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4] benzodiazepine-11-carboxamide (AF-DX384), 4-diphenylacetoxy-N-methyl-piperidine(4-DAMP), para-fluoro-hexa hydro-sila-diphenidol (p-F-HHSiD), himbacine, methoctramine, pirenzepine, and tropicamide) inhibited carbachol-induced contractions in a competitive fashion. The pKb values for these muscarinic receptor antagonists correlated well with the known pKi values of these antagonists for the M3 muscarinic receptor. In uterine strips isolated from mice treated with pertussis toxin (100 microg/kg, i.p. for 96 h), Emax values for carbachol were significantly decreased, but effective concentration that caused 50% of Emax values (EC50) remained unchanged. In uterine strips treated with 4-DAMP mustard (30 nM) and AF-DX116 (1 microM), followed by subsequent washout of AF-DX116, neither carbachol nor N,N,N,-trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide (oxotremorine-M) caused any contractile responses. Both M2 and M3 muscarinic receptor messenger RNAs were detected in the mouse uterus via reverse transcription polymerase chain reaction. Carbachol also caused contraction of uterine strips isolated from M2KO mice, but the concentration-response curve was shifted to the right and downward compared with that for the corresponding wild-type mice. On the other hand, uterine strips isolated from M3KO and M2/M3 double KO mice were virtually insensitive to carbachol. In conclusion, although both M2 and M3 muscarinic receptors were expressed in the mouse uterus, carbachol-induced contractile responses were predominantly mediated by the M3 receptor. Activation of M2 receptors alone did not cause uterine contractions; however, M2 receptor activation enhanced M3 receptor-mediated contractions in the mouse uterus.

Social Behavior in Medulloblastoma: Functional Analysis of Tumor-Supporting Glial Cells

DTIC Science & Technology

2014-07-01

AD_________________ Award Number: W81XWH-11-1-0557 TITLE: Social behavior in Medulloblastoma ... Medulloblastoma : Functional Analysis of Tumor-Supporting 5a. CONTRACT NUMBER Glial Cells 5b. GRANT NUMBER W81XWH-11-1-0557 5c. PROGRAM ELEMENT...AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Medulloblastoma is the

42 CFR 68c.11 - How does an individual receive loan repayments beyond the initial two-year contract?

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY RESEARCH LOAN REPAYMENT PROGRAM § 68c.11 How does... remaining to be repaid and the individual is engaged in research on infertility or contraceptive development...

Heterogeneity of the neuropeptide Y (NPY) contractile and relaxing receptors in horse penile small arteries.

PubMed

Prieto, Dolores; Arcos, Luis Rivera de Los; Martínez, Pilar; Benedito, Sara; García-Sacristán, Albino; Hernández, Medardo

2004-12-01

The distribution of neuropeptide Y (NPY)-immunorective nerves and the receptors involved in the effects of NPY upon electrical field stimulation (EFS)- and noradrenaline (NA)-elicited contractions were investigated in horse penile small arteries. NPY-immunoreactive nerves were widely distributed in the erectile tissues with a particularly high density around penile intracavernous small arteries. In small arteries isolated from the proximal part of the corpora cavernosa, NPY (30 nM) produced a variable modest enhancement of the contractions elicited by both EFS and NA. At the same concentration, the NPY Y(1) receptor agonist, [Leu(31), Pro(34)]NPY, markedly potentiated responses to EFS and NA, whereas the NPY Y(2) receptor agonist, NPY(13-36), enhanced exogenous NA-induced contractions. In arteries precontracted with NA, NPY, peptide YY (PYY), [Leu(31), Pro(34)]NPY and the NPY Y(2) receptor agonists, N-acetyl[Leu(28,31)]NPY (24-36) and NPY(13-36), elicited concentration-dependent contractile responses. Human pancreatic polypeptide (hPP) evoked a biphasic response consisting of a relaxation followed by contraction. NPY(3-36), the compound 1229U91 (Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic(2,4')diamide) and eventually NPY(13-36) relaxed penile small arteries. The selective NPY Y(1) receptor antagonist BIBP3226 ((R)-N(2)-(diphenacetyl)-N-[(4-hydroxyphenyl)methyl]D-arginineamide) (0.3 microM) shifted to the right the concentration-response curves to both NPY and [Leu(31), Pro(34)]NPY and inhibited the contractions induced by the highest concentrations of hPP but not the relaxations observed at lower doses. In the presence of the selective NPY Y(2) receptor antagonist BIIE0246 ((S)-N2-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b,e]azepin-11-y1]-1-piperazinyl]-2-oxoethyl]cyclo-pentyl-N-[2-[1,2-dihydro-3,5 (4H)-dioxo-1,2-diphenyl-3H-1,2, 4-triazol-4-yl]ethyl]-argininamide) (0.3 microM), the Y(2) receptor agonists NPY(13-36) and N-acetyl[Leu(28,31)]NPY (24-36) evoked potent slow relaxations in NA-precontracted arteries, under conditions of nitric oxide (NO) synthase blockade. Mechanical removal of the endothelium markedly enhanced contractions of NPY on NA-precontracted arteries, whereas blockade of the neuronal voltage-dependent Ca(2+) channels did not alter NPY responses. These results demonstrate that NPY can elicit dual contractile/relaxing responses in penile small arteries through a heterogeneous population of postjunctional NPY receptors. Potentiation of the contractions evoked by NA involve both NPY Y(1) and NPY Y(2) receptors. An NO-independent relaxation probably mediated by an atypical endothelial NPY receptor is also shown and unmasked in the presence of selective antagonists of the NPY contractile receptors.

A bill to direct the Secretary of the Interior to allow for prepayment of repayment contracts between the United States and the Uintah Water Conservancy District.

THOMAS, 112th Congress

Sen. Hatch, Orrin G. [R-UT

2011-04-13

House - 11/03/2011 Held at the desk. (All Actions) Notes: For further action, see H.R.818, which became Public Law 112-52 on 11/9/2011. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

Eccentric muscle damage has variable effects on motor unit recruitment thresholds and discharge patterns in elbow flexor muscles.

PubMed

Dartnall, Tamara J; Rogasch, Nigel C; Nordstrom, Michael A; Semmler, John G

2009-07-01

The purpose of this study was to determine the effect of eccentric muscle damage on recruitment threshold force and repetitive discharge properties of low-threshold motor units. Ten subjects performed four tasks involving isometric contraction of elbow flexors while electromyographic (EMG) data were recorded from human biceps brachii and brachialis muscles. Tasks were 1) maximum voluntary contraction (MVC); 2) constant-force contraction at various submaximal targets; 3) motor unit recruitment threshold task; and 4) minimum motor unit discharge rate task. These tasks were performed on three separate days before, immediately after, and 24 h after eccentric exercise of elbow flexor muscles. MVC force declined (42%) immediately after exercise and remained depressed (29%) 24 h later, indicative of muscle damage. Mean motor unit recruitment threshold for biceps brachii was 8.4+/-4.2% MVC, (n=34) before eccentric exercise, and was reduced by 41% (5.0+/-3.0% MVC, n=34) immediately after and by 39% (5.2+/-2.5% MVC, n=34) 24 h after exercise. No significant changes in motor unit recruitment threshold were observed in the brachialis muscle. However, for the minimum tonic discharge rate task, motor units in both muscles discharged 11% faster (10.8+/-2.0 vs. 9.7+/-1.7 Hz) immediately after (n=29) exercise compared with that before (n=32). The minimum discharge rate variability was greater in brachialis muscle immediately after exercise (13.8+/-3.1%) compared with that before (11.9+/-3.1%) and 24 h after exercise (11.7+/-2.4%). No significant changes in minimum discharge rate variability were observed in the biceps brachii motor units after exercise. These results indicate that muscle damage from eccentric exercise alters motor unit recruitment thresholds for >or=24 h, but the effect is not the same in the different elbow flexor muscles.

All Prime Contract Awards by State or Country, Place, and Contractor. Part 3 (Lomita, California-Sand Hill, California).

DTIC Science & Technology

1990-01-01

I 000 MI ~CY) CCCC1)c ) C11 IP )ClOCOCO MC = 1) CO) ~ CYO ~ C’) ~CO =1 ) v C1 = (1 11 1(00 COO f rH -r -I ,r -I * 1 ’ -- - r- 4- r- 4- r- 4- 4- 4- 4...4 < M Cf) 11 0 0-40 0 1-1-40 -400 >-400COO4000 Uo -40 r 11 103M 11 0 t-400 zo 0)0 >-MOO -Moooooooo a 0)o < 11 1 MCI) 11 (71 1-- a* 0) _j 00) >. CIO

Small- Geo Solar Array: New Generation Of Solar Arrays For Commercial Telecom Satellites For Power Ranges Between 2,5 KW And 7,5 KW

NASA Astrophysics Data System (ADS)

Paarmann, Carola; Muller, Jens; Mende, Thomas; Borner, Carsten; Mascher, Rolf

2011-10-01

In the frame of the ESA supported Artes 11 program a new generation of GEO telecommunication satellites is under development. This platform will cover the power range from 2 to 5 kW. ASTRIUM GmbH is contracted to develop and design the Solar Array for this platform. Furthermore the manufacturing and the qualification of a PFM wing for the first flight model is foreseen. The satellite platform, called Small-GEO, is developed under the responsibility of OHB System. This first Small-GEO satellite is designated to be delivered to HISPASAT for operation. The concept of ASTRIUM GmbH is to use all the experiences from the very successful EUROSTAR 2000+, EUROSTAR-3000 and the ALPHABUS platform and to adapt the technologies to the Small- GEO Solar Array. With the benefit of the huge in-orbit heritage of these programs, the remaining risks for the Small-GEO Solar Array can be minimized. The development of the Small-GEO Solar Array extends the ASTRIUM GmbH product portfolio by covering now the complete power range between 2 kW and 31 kW. This paper provides an overview of the different configurations, their main design features and parameters.

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Key Largo Florida - Dixon Illinois)

DTIC Science & Technology

1993-01-01

34(D.( .- I19 - I < o .i 11 1(0 a0 1~f 40 1 00 1 00 4111 -- I-ý I HH I- -’.t Il-03Ie HIt 1 ɘ -4 to C0 (0 N! -I 0 ~ A 11 AIIUII og >0Il0No 01 N (0...1 . 1, 10 0(0 If < 1-1 < <- ɜ < tI MO"( Fig 0 H H 0 1-H H H oil IMON0 ii z 0 0 0) 0 H 00 )- 0 000 .xit I 10 04 110 H- H U0) H’ z HH H- H C>H- IX...0r - - Tt-C 4 <t 4 1 4 4 44 4 4 -4 4 44 4 4 4 444 ( - -V)MZ-1Mr- nC)M tC J C14 4444In 4--Z.O00 it 1 41 ON I t 1 ( jb (C O ) 0) 1 0r 1 t C -1C N0000-404

A Case Study of an Aeronautical Systems Division System Program Office.

DTIC Science & Technology

1982-09-01

11111 -’.-- m 1 1.25 111111.4 1 1.6_ MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARDS-1963-A If. t 1’ I I( N 2> - .~.. * .~ .~-I ~ k~’ ~K ~r...office....assesses.................. 8 Section 11 The Standard Aircraft Sensor UnitProgram........ 32 Section III Terms and Defnition ...contracts with industry, (b) test programs with both industry and other DOD organizations, (c) aircraft production or modification programs with both

Engineered Potentials and Dynamics of Ultracold Quantum Gases Under the Microscope

DTIC Science & Technology

2014-05-09

CONTRACT OR GRANT NUMBER: DESCRIPTION OF MATERIAL INSTITUTION: PRINCIPAL INVESTIGATOR: Paola Cappellaro TYPE REPORT: Ph.D. Dissertation PERIOD...CONTRACT NUMBER Engineered potentials and dynamics of ulu·acold quantum gases W911NF-11-1-0400 under the microscope Sb. GRANT NUMBER Sc. PROGRAM...Schnorrberger, M. Moreno- Cardoner , S. Fölling, and I. Bloch, “Counting atoms using interaction blockade in an optical superlat- tice,” Phys. Rev. Lett

Defense Contracting in Iraq: Issues and Options for Congress

DTIC Science & Technology

2007-11-15

minimum value of $613,677 with a contract period of one base year followed by up to four one- year options with CRS-4 12 U.S. Army Sustainment Command...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release...Iraq. The proposed Fiscal Year (FY) 2008 Defense Authorization bill, H.R. 1585, contains provisions which, as an example, would broaden legal

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Dell City Oklahoma - Wayne (County) Penn)

DTIC Science & Technology

1993-01-01

0 NN*N0"of I I" ur’-r--?- -4’r!’. 4- C. 5 (D U)LAU’) 314400’N034 C") M C - *’ro ’) 4...J. 04 0 ) 0 01 D4 ". 5 C> -:-D1 o) iD( 0 ( 0 ( 0 ( w4 (00- 44 o" itA- Z 0MOO ZZLaU-13.. -WLa in C3 LA XY (oi4 I4 0 4o4III- 0 < 13. 0 ) 13.43- U) u ~ J2...0000000 30 00-IN17,10 0 0 01 000 > C 0 0 00000 0000C 000 a ca -4NCj0 QI 0 0 0 0 00 0

AQCESS (Automated Quality of Care Evaluation Support System) Ad Hoc Report Generator Quick Reference Guide.

DTIC Science & Technology

1986-06-01

GUIDE JJ TRIMIS Program Office 5401 Westbard Avenue Bethesda, Maryland 20816 W" V NDC Federal Systems. lnc.._" 1300 Piccard Drive .. -Rockville, Marylcn...Project/Teay iUnft1. DOD A A fri-Service Medical Information Systems Program office 11. Contract(C) orGaw a 5401 Westbard Avenue (C) Bethesda, MD 20816

76 FR 55061 - Information Collection Being Reviewed by the Federal Communications Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... contained in Sections 4(i), 303(r), and 616 of the Communications Act of 1934, as amended. Total Annual... Programming Distribution and Carriage, MB Docket No. 07-42, FCC 11-119. In the Second Report and Order, the... a temporary standstill of the price, terms, and other conditions of an existing programming contract...

In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.

PubMed

Lecci, A; Giuliani, S; Tramontana, M; Meini, S; De Giorgio, R; Maggi, C A

1996-05-01

In urethane-anaesthetized rats, moderate colonic distention (0.5 ml) induced reflex rhythmic contractions (5 mm Hg amplitude and 1.1 cycles/min frequency). Senktide (1-10 nmol/kg, i.v.), a tachykinin NK3 receptor selective agonist, transiently suppressed distension-induced contractions. SR 142,801 (1-10 mumol/kg i.v.), a non-peptide tachykinin NK3 receptor antagonist, had no effect on distension-induced contractions but prevented the inhibitory effect of senktide. Infusion of N-omega-nitro-1-arginine methyl esther hydrochloride (L-NAME, 20 mumol/ml/h, i.v) increased the amplitude of colonic contractions and decreased the inhibitory effect of senktide. Hexamethonium (15 mumol/ml/h, i.v.) or atropine (1 mumol/ml/h, i.v.) inhibited the distension-induced contractions. In hexamethonium- or atropine-treated rats, senktide (10 nmol/kg) transiently and selectively enhanced the amplitude of contractions. Also SR 142,801 (10 mumol/kg), but not its inactive enantiomer SR 142,806, increased both amplitude and frequency of contractions. During continuous infusion of L-NAME and hexamethonium or atropine both frequency and amplitude of distension-induced colonic contractions were higher than when in hexamethonium or atropine only. Senktide (10 nmol/kg) had no effect and SR 142,801 (10 mumol/kg) produced a slight enhancement of colonic contractions. Infusion of sodium nitroprusside (3 mumol/ml/h, i.v.) decreased amplitude and frequency of distension-induced contractions. SR 142,801 had no effect in the presence of the nitric oxide (NO) donor. We conclude that tachykinins acting through NK3 receptors exert at least four different actions on colonic motility activated by distension: 1) a hexamethonium-resistant, NO-dependent, suppressant effect on contractions; 2) a hexamethonium-sensitive, NO-independent inhibitory effect on the amplitude of contractions; 3) a hexamethonium-resistant, NO-independent inhibitory effect on the amplitude of contractions and 4) a hexamethonium resistant and L-NAME-sensitive excitatory effect on amplitude of contractions. The prevalent inhibitory effect evoked in normal conditions along with the excitatory activity induced by SR 142,801 on hexamethonium-resistant colonic motility indicates that tachykinins, acting through neuronal NK3 receptors, activate NO-dependent and NO-independent inhibitory neurotransmission in the rat colon.

Protons act as a transmitter for muscle contraction in C. elegans

PubMed Central

Beg, Asim A.; Ernstrom, Glen G.; Nix, Paola; Davis, M. Wayne; Jorgensen, Erik M.

2008-01-01

Muscle contraction is normally mediated by the release of neurotransmitters from motor neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to stimulate muscle contraction. During the C. elegans defecation motor program the posterior body muscles contract even in the absence of neuronal inputs or vesicular neurotransmission. In this study, we demonstrate that the space between the intestine and the muscle is acidified just prior to muscle contraction and that the release of caged protons is sufficient to induce muscle contraction. PBO-4 is a putative Na+/H+ ion exchanger expressed on the basolateral membrane of the intestine, juxtaposed to the posterior body muscles. In pbo-4 mutants the extracellular space is not acidified and the muscles fail to contract. The pbo-5 and pbo-6 genes encode subunits of a ‘cys-loop’ proton-gated cation channel required for muscles to respond to acidification. In heterologous expression assays the PBO receptor is half-maximally activated at a pH of 6.8. The identification of the mechanisms for release and reception of proton signals establishes a highly unusual mechanism for intercellular communication. PMID:18191228

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (General Image Engineering Corp - H E H Heins GMBH)

DTIC Science & Technology

1993-01-01

CDO-4 zaw O il E sOO Mcq it 0 0 0 0 0 0D (’AN 00 ɜ 1 MI 10 3a’COON U.L 1-1 Ui. 4 -. C>O - LA- WA 1-1 La-O)OC 1-14- Wr2CO iO z- 0 0) 01 a 00 0 0 0 0 4...0 c) tun r- 1-1 In a) cli In r- f-- to <> V) r- r- I- -i ,1 14 ed < o c) 11 00 (0 (0 (D (10 Z) (0 00 0 C> o C> 00 (Tf o 00 C) C, 00 qzr 00-4 r- t- P

77 FR 43723 - Energy Efficiency and Conservation Loan Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... communities by investing in energy efficiency, and (5) encouraging the use of renewable energy fuels for both... contracts. Impacts The new Subpart H. for the Energy Efficiency and Conservation Loan Program can have several economic impacts. The benefits include: (1) The value of purchased energy saved; (2) the value of...

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 5. (Cold Spring Construction Co.-Dat Construction, Inc.)

DTIC Science & Technology

1988-01-01

0 0 00 00 00 000 000 00 Zo@00- 01 4 4 0- 4 4c cc 44 4 04C - ICON IW W.) I.- - 1- 0 ~ 0C) O - CO o@00- 1o ZL 0 0ol 40 14- 00 00ifLA1 00 00 0 0 000-4 ZN...0-4In -4 300 co 341- 0) 40 A0n 1- 1MCIC 3 .j > > > > 4c .i > 00NVO 0I00W.3N III d4 U) (16 (A 0. 1L. 00.1*. .L. 4 ICON 1 1.- 00l.- 00000000 lK’IAC0N I...0000 340M 11� 100 a5 - 3444444 0 IZEZ 3 0 CON a(0((Il(NfN00-4 N tow0 O~4(.0 ~ 1(0 alocos00 < 0" I 00000004fl.4-N00 0(09- Mm01 momoul-NM-4U

Ammunition Cost Research Study. Volume I.

DTIC Science & Technology

1983-01-01

0.048 4,000,000 1.72 1.74 M717 PD 0.25 571,490 8.22 6.13 M567 PD 1.30 300,000 10.43 17.22 M503A2 PD 0.34 814,701 10.64 7.28 M739 PD 1.43 915,837 10.65...M503A2 PD 0.34 252,336 10.73 7.58 M567 PD 1.30 1,071,100 11.23 16.29 M739 PD 1.43 915,837 11.30 17.47 M720 PD 2.10 90,000 11.41 23.46 m567 PD 1.30...14.86 12.91 M524A6 PD 1.27 3,982,150 15.11 13.04 M524A6 PD 1.27 3,181,102 15.44 13.81 M739 PD 1.43 3,168,072 15.47 14.86 M524A6 PD 1.27 3,045,000 17.37

Common Ada Missile Packages. Phase 2. (CAMP-2). Volume 2. 11th Missile Demonstration

DTIC Science & Technology

1988-11-01

report describes the work performed, Ihe results obtained, and the conclusions reached during the Common Ada Missile Packages Phase-2 (CAMP-2) contract ... contract was performed between Sep- tember 1985. and March 1988. The MDAC-STL CAMP program manager was: Dr. Daniel G. McNicholl Technology Branch...j DEC Code Management System X X Software Development Files x x Development Status Database x ! X i Smart Cade Counter X j

[The fasting calcium/creatinine ratio in patients with calcium stones and the relation with hypercalciuria and phosphocalcium metabolism].

PubMed

Arrabal-Polo, Miguel Ángel; del Carmen Cano-García, María; Arrabal-Martín, Miguel

2016-04-01

To determine the importance of fasting calcium/creatinine ratio in patients with calcium stones and its relation with hypercalciuria and phospho-calcium metabolism. Cross-sectional study including 143 patients divided into two groups according to fasting calcium/creatinine. Group 1: 66 patients (calcium/ creatinine<0.11); Group 2: 77 patients (calcium/ creatinine>0.11). A comparative study is performed between groups including phospho-calcium metabolism parameters and excretion of urinary lithogenic markers. Linear correlation studying calciuria and fasting calcium/ creatinine was performed. SPSS 17.0 statistical analysis software was used, considering p≤0.05. It is noteworthy that group 2 had increased 24 h urine calcium excretion in comparison to group 1 (229.3 vs 158.1; p=0.0001) and calcium/citrate (0.47 vs 0.34; p=0.001). There is a positive and significant correlation between calcium levels in 24 h urine and fasting calcium/creatinine (R=0.455; p=0.0001) and a cutoff is set at 0.127 (sensitivity 72%, specificity 66%) to determine hypercalciuria (>260 mg in 24 h). Increased fasting calcium/creatinine determines increased 24 hours calcium excretion, although the sensitivity and specificity to determine hypercalciuria is not high.

Advanced Pediatric Brain Imaging Research and Training Program

DTIC Science & Technology

2013-10-01

diffusion tensor imaging and perfusion ( arterial spin labeling) MRI data and to relate measures of global and regional brain microstructural organization...AD_________________ Award Number: W81XWH-11-2-0198 TITLE: Advanced Pediatric Brain Imaging...September 2013 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Advanced Pediatric Brain Imaging Research and Training Program 5b. GRANT NUMBER W81XWH

NextGen Weather Plan, Version 1.1

DTIC Science & Technology

2009-09-17

values of weather parameters at a station or over an area. In this paper, we often refer to aeronautical climatology, which is the application of the data...Joint Planning and Development Office NEXTGEN Weather Plan Version 1.1 Version 1.1 i September 17, 2009 Report Documentation Page Form...COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE NextGen Weather Plan 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

Reliability of near-infrared spectroscopy for measuring biceps brachii oxygenation during sustained and repeated isometric contractions.

PubMed

Muthalib, Makii; Millet, Guillaume Y; Quaresima, Valentina; Nosaka, Kazunori

2010-01-01

We examine the test-retest reliability of biceps brachii tissue oxygenation index (TOI) parameters measured by near-infrared spectroscopy during a 10-s sustained and a 30-repeated (1-s contraction, 1-s relaxation) isometric contraction task at 30% of maximal voluntary contraction (30% MVC) and maximal (100% MVC) intensities. Eight healthy men (23 to 33 yr) were tested on three sessions separated by 3 h and 24 h, and the within-subject reliability of torque and each TOI parameter were determined by Bland-Altman+/-2 SD limits of agreement plots and coefficient of variation (CV). No significant (P>0.05) differences between the three sessions were found for mean values of torque and TOI parameters during the sustained and repeated tasks at both contraction intensities. All TOI parameters were within+/-2 SD limits of agreement. The CVs for torque integral were similar between the sustained and repeated task at both intensities (4 to 7%); however, the CVs for TOI parameters during the sustained and repeated task were lower for 100% MVC (7 to 11%) than for 30% MVC (22 to 36%). It is concluded that the reliability of the biceps brachii NIRS parameters during both sustained and repeated isometric contraction tasks is acceptable.

Lake St. Clair: Storm Wave and Water Level Modeling

DTIC Science & Technology

2013-06-01

R. A. Luettich, C. Dawson, V. J. Cardone , A. T. Cox, M. D. Powell, H. J. Westerink, and H. J. Roberts. 2010. A high resolution coupled riverine flow...Storm Wave and Water Level Modeling 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Tyler J. Hesser

Overview of long pulse H-mode operation on EAST

NASA Astrophysics Data System (ADS)

Gong, X.; Garofalo, A. M.; Wan, B.; Li, J.; Qian, J.; Li, E.; Liu, F.; Zhao, Y.; Wang, M.; Xu, H.; EAST Team

2017-10-01

The EAST research program aims to demonstrate steady-state long-pulse high-performance H-mode operations with ITER-like poloidal configuration and RF-dominated heating schemes. In the recent experimental campaign, a long pulse fully non-inductive H-mode discharge lasting over 100 seconds using the upper ITER-like tungsten divertor has been achieved in EAST. This scenario used only RF heating and current drive, but also benefitted from an integrated control of the wall conditioning, plasma configuration, divertor heat flux, particle exhaust, impurity management and superconducting coils safety. Maintaining effective coupling of multiple RF heating and current drive sources on EAST is a critical ingredient. This long pulse discharge had good energy confinement, H98,y2 1.1-1.2, and all of the plasma parameters reach a true steady-state. Power balance indicates that the confinement improvement is due partly to a significantly reduced core electron transport inside minor radius rho<0.4. This work was supported by the National Magnetic Confinement Fusion Program of China Contract No. 2015GB10200 and the US Department of Energy Contract No. DE-SC0010685.

Soft dipole resonance and halo structure of 11Li

NASA Astrophysics Data System (ADS)

Kanungo, Rituparna

2016-03-01

The discovery of the nuclear halo in rare isotopes has ushered a new era in nuclear science breaking the boundaries of conventional concepts. The halo properties elucidate new features that till date remain a challenge to decipher from fundamental principles. Our knowledge on the halo is still gradually unfolding and reaching new levels of precision as efforts continue towards new experimental developments. In recent times, low-energy reactions in inverse kinematics have become possible providing a wealth of new structure information. In this presentation we will introduce a new reaction spectroscopy facility, IRIS, with a novel thin windowless solid H2/D2 target for studying transfer and inelastic scattering reactions of rare isotopes with very low yields. It was postulated that the loosely bound halo of two neutrons may lead to a core-halo oscillation resulting in dipole resonance(s) at very low excitation energy, called soft dipole resonance. Despite decades of search for this new phenomenon using various techniques, such as, no firm conclusion was reached. The presentation will discuss new results from IRIS that shows evidence of a soft dipole resonance state and further unveils its isoscalar character. New results of neutron transfer from 11Li will be presented showing resonance state(s) in the neutron unbound 10Li subsystem hence facilitating a description of the wavefunction of 11Li. NSERC, Canada Foundation for Innovation, Nova Scotia Research and Innovation Trust, grant-in-aid program of the Japanese government under Contract No. 23224008, US DOE Contract No. DE-AC52-07NA27344.

Composite Warfare Doctrine - Providing the JFMCC with the Optimal Command and Control Method for Amphibious Operations

DTIC Science & Technology

2015-05-15

Method for Amphibious Operations 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Major Kevin J...7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Joint Military...SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11 SPONSOR/MONITOR’S REPORT 11. SPONSOR

Evaluation of the Advanced Situational Awareness Training Pilot Program

DTIC Science & Technology

2017-02-01

M., Holder, L. D., Leibrecht, B. C ., Garland, D. J ., Wampler, R. L., & Matthews, M. D. (2000). Modeling and measuring situation awareness in the...Ware, L. J ., Ratcliff, J . J ., & Irvin, C . R. (2009). Evidence of the camera perspective bias in authentic videotaped interrogations: Implications...Advanced Situational Awareness Training Pilot Program 5a. CONTRACT OR GRANT NUMBER W5J9CQ-11- C -0040 5b. PROGRAM ELEMENT NUMBER 633007 6

Avionics Simulation, Development and Software Engineering

NASA Technical Reports Server (NTRS)

Francis, Ronald C.; Settle, Gray; Tobbe, Patrick A.; Kissel, Ralph; Glaese, John; Blanche, Jim; Wallace, L. D.

2001-01-01

This monthly report summarizes the work performed under contract NAS8-00114 for Marshall Space Flight Center in the following tasks: 1) Purchase Order No. H-32831D, Task Order 001A, GPB Program Software Oversight; 2) Purchase Order No. H-32832D, Task Order 002, ISS EXPRESS Racks Software Support; 3) Purchase Order No. H-32833D, Task Order 003, SSRMS Math Model Integration; 4) Purchase Order No. H-32834D, Task Order 004, GPB Program Hardware Oversight; 5) Purchase Order No. H-32835D, Task Order 005, Electrodynamic Tether Operations and Control Analysis; 6) Purchase Order No. H-32837D, Task Order 007, SRB Command Receiver/Decoder; and 7) Purchase Order No. H-32838D, Task Order 008, AVGS/DART SW and Simulation Support

Gene expression profiling in human skeletal muscle during recovery from eccentric exercise

PubMed Central

Mohoney, D. J.; Safdar, A.; Parise, G.; Melov, S.; Fu, Minghua; MacNeil, L.; Kaczor, J.; Payne, E. T.; Tarnopolsky, M. A.

2009-01-01

We used cDNA microarrays to screen for differentially expressed genes during recovery from exercise-induced muscle damage in humans. Male subjects (n = 4) performed 300 maximal eccentric contractions, and skeletal muscle biopsy samples were analyzed at 3 h and 48 h after exercise. In total, 113 genes increased 3 h postexercise, and 34 decreased. At 48 h postexercise, 59 genes increased and 29 decreased. On the basis of these data, we chose 19 gene changes and conducted secondary analyses using real-time RT-PCR from muscle biopsy samples taken from 11 additional subjects who performed an identical bout of exercise. Real-time RT-PCR analyses confirmed that exercise-induced muscle damage led to a rapid (3 h) increase in sterol response element binding protein 2 (SREBP-2), followed by a delayed (48 h) increase in the SREBP-2 gene targets Acyl CoA:cholesterol acyltransferase (ACAT)-2 and insulin-induced gene 1 (insig-1). The expression of the IL-1 receptor, a known regulator of SREBP-2, was also elevated after exercise. Taken together, these expression changes suggest a transcriptional program for increasing cholesterol and lipid synthesis and/or modification. Additionally, damaging exercise induced the expression of protein kinase H11, capping protein Z alpha (capZα), and modulatory calcineurin-interacting protein 1 (MCIP1), as well as cardiac ankryin repeat protein 1 (CARP1), DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. In summary, using DNA microarrays and RT-PCR, we have identified novel genes that respond to skeletal muscle damage, which, given the known biological functions, are likely involved in recovery from and/or adaptation to damaging exercise. PMID:18321953

Function algorithms for MPP scientific subroutines, volume 1

NASA Technical Reports Server (NTRS)

Gouch, J. G.

1984-01-01

Design documentation and user documentation for function algorithms for the Massively Parallel Processor (MPP) are presented. The contract specifies development of MPP assembler instructions to perform the following functions: natural logarithm; exponential (e to the x power); square root; sine; cosine; and arctangent. To fulfill the requirements of the contract, parallel array and solar implementations for these functions were developed on the PDP11/34 Program Development and Management Unit (PDMU) that is resident at the MPP testbed installation located at the NASA Goddard facility.

Synthesis of Cubane Based Energetic Molecules

DTIC Science & Technology

1993-04-13

Judahi Goldwasser Code 1132P Contract No. N00014-86-C-0699 93 08590 SRI Project Number 2723 93,08590 David S. Ross, Director 7) Chemistry Laborator David...1132p 800 N. Quincy St. Arlinston. VA 22217-5000 11. SUPPLEMENTARY NOTES Final Project Report 12a. DISTRIIUTION/AVAJLABIL[TY STATEMENT 12b. DISTRIBU71ION...course of our studies here and in a parallel ONR sponsored program (SRI project number 6654, ONR contract No. N00014-88-C-0537), we discovered and

The perfused swine uterus model: long-term perfusion

PubMed Central

2012-01-01

Background It has previously been shown that the viability of swine uteri can be maintained within the physiological range in an open perfusion model for up to 8 hours. The aim of this study was to assess medium- to long-term perfusion of swine uteri using a modified Krebs–Ringer bicarbonate buffer solution (KRBB) in the established open perfusion model. Methods In an experimental study at an infertility institute, 30 swine uteri were perfused: group 1: n = 11, KRBB; group 2: n = 8, modified KRBB with drainage of perfusate supernatant; group 3: n = 11, modified KRBB with drainage of perfusate every 2 h and substitution with fresh medium. Modified and conventional KRBB were compared with regard to survival and contraction parameters: intrauterine pressure (IUP), area under the curve (AUC), and frequency of contractions (F). Results Modified KRBB showed significantly higher IUP, AUC, and F values than perfusion with conventional KRBB. In group 3, the organ survival time of up to 17 h, with a 98% rate of effective contraction time, differed significantly from group 1 (P < 0.001). Conclusions Using modified KRBB in combination with perfusate substitution improves the open model for perfusion of swine uteri with regard to survival time and quality of contraction parameters. This model can be used for medium- to long-term perfusion of swine uteri, allowing further metabolic ex vivo studies in a cost-effective way and with little logistic effort. PMID:23241226

Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.

PubMed

Barchasz, E; Naline, E; Molimard, M; Moreau, J; Georges, O; Emonds-Alt, X; Advenier, C

1999-08-20

Interleukin-1beta has been reported to induce airway hyperresponsiveness in several animal models. In this study, we have investigated whether interleukin-1beta was able to potentiate the contractions of human isolated small bronchi (internal diameter < or = 1 mm) provoked by a specific tachykinin NK1 receptor agonist, [Sar9,Met(O2)11]substance P. Pre-incubation of human isolated small bronchi with interleukin-1beta (10 ng/ml, in Krebs-Henseleit solution, at 21 degrees C for 15 h) potentiated the contractile response to [Sar9,Met(O2)11]substance P. It also increased the [Sar9,Met(O2)11]substance P-induced release of thromboxane B2, the stable metabolite of thromboxane A2. Indomethacin (10(-6) M), a non-specific cyclooxygenase inhibitor, or GR 32191 ((1R-(1alpha(Z)),2beta,3beta,5alpha))-(+)-7-(5-(((1,1' -biphenyl)-4-yl)-methoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-4-hept enoic acid, hydrochloride) (10(-6) M), a prostanoid TP-receptor antagonist, blocked the contractions induced by [Sar9,Met(O2)11]substance P both in control experiments and after interleukin-1beta pre-treatment, indicating that prostanoids and thromboxane receptors are directly implicated in the [Sar9,Met(O2)11]substance P-induced contractile response. The thromboxane mimetic U-46619 (10(-8)-10(-6) M) (9,11-dideoxy-11alpha,9alpha-epoxymethano-prostaglandin F2alpha)-induced contractions of human isolated small bronchi were not enhanced by interleukin-1beta pre-treatment, suggesting that no up-regulation of thromboxane receptors occurred. Furthermore, the cyclooxygenase-2 inhibitor CGP 28238 (6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanon e) (10(-6) M) had no direct effect on [Sar9,Met(O2)11]substance P-provoked contractions, but inhibited the interleukin-1beta-induced potentiation of [Sar9,Met(O2)11]substance P response. In conclusion, our results show that interleukin-1beta pre-treatment is able to potentiate the contractions of isolated human small bronchi provoked by [Sar9,Met(O2)11]substance P both by increasing prostanoid synthesis and by inducing a cyclooxygenase-2 pathway.

48 CFR 11.701 - Supply contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Supply contracts. 11.701 Section 11.701 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Variation in Quantity 11.701 Supply contracts. (a) A fixed-price supply contract may...

Studies of the mechanism of passive anaphylaxis in human airway smooth muscle.

PubMed

Davis, C; Jones, T R; Daniel, E E

1983-07-01

This investigation was carried out to study allergic contraction of passively sensitized human airway smooth muscle in response to specific antigen challenge. We attempted to determine the role played by histamine, slow reaction substances (SRSs), and cyclooxygenase products in the mediation of this response in tracheal smooth muscle. Tissues were passively sensitized with serum from ragweed-sensitive patients (15 h, 4 degrees C). Subsequent challenge with ragweed antigen produced a slowly developing contraction. The peak contraction to a dose producing a maximal response was 37 +/- 6% of the carbachol maximum. Mepyramine (5 X 10(-6) M) did not alter the contraction. Methylprednisolone (2 X 10(-5) M) attenuated the response to antigen but had no significant effect on the contractile response to arachidonic acid. Indomethacin (5.6-28 X 10(-6) M) enhanced the peak antigen-induced contractions by 25 +/- 11% whereas 5,8,11,14-eicosatetraynoic acid (6.4 X 10(-5) M) selectively attenuated the antigen-induced contraction by 86 +/- 12%. Nordihydroguarietic acid (6-12 X 10(-6) M) attenuated both the antigen plus arachidonate induced responses. FPL-55712 (1-2 X 10(-6) M) antagonized the contractions to antigen. Compound 48/80 and goat antihuman immunoglobulin E produced similar slowly developing contractions in sensitized and in some nonsensitized tissues. These responses, except for an early component of the response to 48/80, were independent of histamine and were reversed by FPL-55712. These findings suggest that arachidonic acid metabolites mediate (slow reacting substances) and modulate (prostaglandins) allergic contraction of human airway smooth muscle while any histamine released contributes little or nothing to the contraction in the larger airways.

Carbon Nanotube Based Flexible Supercapacitors

DTIC Science & Technology

2011-04-01

Carbon Nanotube Based Flexible Supercapacitors by Christopher M. Anton and Matthew H. Ervin ARL-TR-5522 April 2011...Carbon Nanotube Based Flexible Supercapacitors Christopher M. Anton and Matthew H. Ervin Sensors and Electron Devices Directorate, ARL...September 2010 4. TITLE AND SUBTITLE Carbon Nanotube Based Flexible Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

13 CFR 305.11 - Contract awards; early construction start.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Contract awards; early construction start. 305.11 Section 305.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION... § 305.11 Contract awards; early construction start. EDA must determine that the award of all contracts...

13 CFR 305.11 - Contract awards; early construction start.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Contract awards; early construction start. 305.11 Section 305.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION... § 305.11 Contract awards; early construction start. EDA must determine that the award of all contracts...

Environmental controls on the boron and strontium isotopic composition of aragonite shell material of cultured Arctica islandica

NASA Astrophysics Data System (ADS)

Liu, Y.-W.; Aciego, S. M.; Wanamaker, A. D., Jr.

2015-02-01

Ocean acidification, the decrease in ocean pH associated with increasing atmospheric CO2, is likely to impact marine organisms, particularly those that produce carbonate skeletons or shells. Therefore it is important to investigate how environmental factors (seawater pH, temperature and salinity) influence the chemical compositions in biogenic carbonates. In this study we report the first high-resolution strontium (87Sr / 86Sr and δ88 / 86Sr) and boron (δ11B) isotopic values in the aragonite shell of cultured Arctica islandica (A. islandica). The 87Sr / 86Sr ratios from both tank water and shell samples show ratios nearly identical to the open ocean, which suggests that the shell material reflects ambient ocean chemistry without terrestrial influence. The 84Sr-87Sr double spike resolved shell δ 88 / 86Sr and Sr concentration data show no resolvable change throughout the culture period and reflect no theoretical kinetic mass fractionation throughout the experiment despite a temperature change of more than 15 °C. The δ11B records from the experiment show at least a 5‰ increase through the culture season (January 2010-August 2010), with low values from beginning to week 19 and higher values hereafter. The larger range in δ11B in this experiment compared to predictions based on other carbonate organisms (2-3‰) suggests that a species-specific fractionation factor may be required. A relatively strong correlation between the Δ pH (pHshell-pHsw) and seawater pH (pHsw) was observed (R2 = 0.34), which suggests that A. islandica partly regulates the pH of the extrapallial fluid. However, this proposed mechanism only explains approximately 34% of the variance in the δ11B data. Instead, a rapid rise in δ11B after week 19 suggests that the boron uptake of the shell changes when a temperature threshold of 13 °C is reached.

Health Reports.

DTIC Science & Technology

1992-09-01

Futui’e Structure of Veterans’ Health Program (Aug. 11, 1992, GAO/T-HRD-92-53). Recombinant Bovine Growth Hormone: FDA Approval Should be Withheld Until...the Mastitis Issue Is Resolved (Aug. 6, 1992, GAO/PEMD-92-26). VA Health Care: Inadequate Controls Over Scarce Medical Specialist Contracts (Aug. 5

A Comparison of Electrolytic Capacitors and Supercapacitors for Piezo-Based Energy Harvesting

DTIC Science & Technology

2013-07-01

A Comparison of Electrolytic Capacitors and Supercapacitors for Piezo-Based Energy Harvesting by Matthew H. Ervin, Carlos M. Pereira, John R...Capacitors and Supercapacitors for Piezo-Based Energy Harvesting Matthew H. Ervin Sensors and Electronic Devices Directorate, ARL Carlos M. Pereira... Supercapacitors for Piezo-Based Energy Harvesting 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Matthew H

Annual Technical Report to the Office of Naval Research.

DTIC Science & Technology

1981-11-01

7 A A1 208 MICHIGAN TECHNOLOGICAL UNI V HOUGHTON DEP T OF MFTALLU--ETC IG 11/6 ANNUAL TECHNICAL REPORT TO THE OFFICE OF NAVAL RESEARCH(U) NOV 81 D...A KOSS N00014-76-C-0037 UNCLASSIFIED NLmhEIIIIIIEIIII ElllllEllEllEE ANNUAL TECHNICAL REPORT TO THE OFFICE OF NAVAL RESEARCH CONTRACT No, N00014-76-C... the Office of Naval Research through Contract No. N00014-76-C-0037, NR 031-756. 22 References 1. K. Okazaki, M. Kagawa, and H. Conrad, Acta. Met. 27

Korea in Postwar U.S. Security Policy,

DTIC Science & Technology

1982-06-01

the near future." 0" Memorandum by Director of the Office of Far Eastern Affairs (Butterworth) to the Under Secretary of State (Lovett)" in ibid., pp... under the Mutual Defense Assistance Act was hindered by the requirement that deliveries await new contracts 13For an interesting retrospective... under GARIOA, most was in the form of food, fertilizer, clothing, fuel, and other commodities, only 14% went to reconstruction efforts. 19 This short

Aviation Security: Efforts to Measure Effectiveness and Address Challenges

DTIC Science & Technology

2003-11-05

AND SUBTITLE AVIATION SECURITY Efforts to Meassure Effectiveness and Address Challenges 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...screeners in becoming more adept at detecting hard -to-spot threat objects. However, TIP was shut down immediately following the September 11

24 CFR 135.11 - Other laws governing training, employment, and contracting.

Code of Federal Regulations, 2011 CFR

2011-04-01

... preference in the evaluation of bids or proposals. (2) Flexible Subsidy Program. Multifamily project... practices it selects provide preference to section 3 business concerns. (b) Procurement standards for other... statute that expressly encourages a geographic preference in the evaluation of bids or proposals. (c...

Electron-Rich Carboranes. Studies of a Stereochemically Novel System, (CH3)4C4B7H9, and 11-Vertex Arachno Cluster.

DTIC Science & Technology

1981-01-01

FINSTER , R N GRIMES NOGOIR-75C-0305 UNCLASSIFIED TR-37 NL EOMEEEhE OFFICE OF NAVAL RESEARCH CONTRACT NO. i14.-7-C-31 q,4 TECHNICAL REPORT NO. 37L" 0...Electron-Rich Carboranes. Studies of a Stereochemically Novel System, (CH") 4C4 BH 9 , an 11-Vertex Arachno Cluster. .) David C./ Finster aad Russell N...System, (CH3 )4C4B7H9 , an l-Vertex Arachno Cluster 1 David C. Finster and Russell N. Grimes* Contribution from the Department of Chemistry University of

Characteristics and Pay of Federal Civilian Employees

DTIC Science & Technology

2007-03-01

of Federal Civilian Employees 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...dental assistants , safety technicians, photographers, cartographic tech- nicians, and food inspectors. In December 2005, about 370,000 employees ...promotion program . CHARACTERISTICS AND PAY OF FEDERAL CIVILIAN EMPLOYEES 11pay. Sixty percent of them also switch to a different occu- pation when they

Principles of Work Sample Testing. 2. Evaluation of Personnel Testing Programs

DTIC Science & Technology

1979-04-01

i ARI TECHNICAL REPORT VE TR-79-A9 Principles of Work Sample Testing: II. Evaluation of Personnel Testing Programs by Robert M. Guion BOWLING GREEN ...STATE UNIVERSITY .Bowling Green , Ohio 43403 April 1979 Contract DAHC 19-77-C-0007 UK 0-. Prepared for C-, LA. U.S. ARMY RESEARCH INSTITUTE w for the...NAME AND ADDRESS V.PROGRAM ELEMENT. PROJECT. TASK Bowl iiq Green ’tate UniversityV Bowlilnq Green , Ohio 4 340i3 11. CONTROLLING OFFICE NAME AND ADDRESS

High Resolution Satellite Observations of Mesoscale Oceanography in the Tasman Sea 1978-79.

DTIC Science & Technology

1982-02-01

c:TATI!S clS (); 11 "AP ) -q I-Tj4LS IF t H~FI~fO~InPO T64TC. 4nOA AOF (.IVFt, IN THP~ r14TA L1cTc. "offre FQQ1" VS T-W PIFFF,.l4Cj(F (mmfh1P 1 5 fi ~~S 1...8217;’IF P. 1"AOTI ToS T 41 APPAQFA’YT IJMI- rTO -ANC’F T$:NP;:-ATIPFh𔃻 OF T"F S1t)FAcVI- *ATtP PS PEFTFPMNtFr- FP0k’ THF rCOT ImA(F (frSU’Os T- ŕ TATrS...2r 0?79 -381$ 1495? 305-034&)0-? 1 A GnQlSFC 20 -30 9 115 NIJMQFP OF TAGFS PPIOPITY P, GPO )IIP(3) = 43 NIIMRFP OF TMAGFS PPIOPITY H= 26A TOTAI

The Effects of Two Different Stretching Programs on Balance Control and Motor Neuron Excitability

ERIC Educational Resources Information Center

Kaya, Fatih; Biçer, Bilal; Yüktasir, Bekir; Willems, Mark E. T.; Yildiz, Nebil

2018-01-01

We examined the effects of training (4d/wk for 6 wks) with static stretching (SS) or contract-relax proprioceptive neuromuscular facilitation (PNF) on static balance time and motor neuron excitability. Static balance time, H[subscript max]/M[subscript max] ratios and H-reflex recovery curves (HRRC) were measured in 28 healthy subjects (SS: n = 10,…

Probabilistic Sensitivity Analysis with Respect to Bounds of Truncated Distributions (PREPRINT)

DTIC Science & Technology

2010-04-01

AFRL-RX-WP-TP-2010-4147 PROBABILISTIC SENSITIVITY ANALYSIS WITH RESPECT TO BOUNDS OF TRUNCATED DISTRIBUTIONS (PREPRINT) H. Millwater and...5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62102F 6. AUTHOR(S) H. Millwater and Y. Feng 5d. PROJECT...Z39-18 1 Probabilistic Sensitivity Analysis with respect to Bounds of Truncated Distributions H. Millwater and Y. Feng Department of Mechanical

LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b.

PubMed

Nanazashvili, Mikheil; Sánchez-Rodríguez, Jorge E; Fosque, Ben; Bezanilla, Francisco; Sackin, Henry

2018-01-09

Gating of the mammalian inward rectifier Kir1.1 at the helix bundle crossing (HBC) by intracellular pH is believed to be mediated by conformational changes in the C-terminal domain (CTD). However, the exact motion of the CTD during Kir gating remains controversial. Crystal structures and single-molecule fluorescence resonance energy transfer of KirBac channels have implied a rigid body rotation and/or a contraction of the CTD as possible triggers for opening of the HBC gate. In our study, we used lanthanide-based resonance energy transfer on single-Cys dimeric constructs of the mammalian renal inward rectifier, Kir1.1b, incorporated into anionic liposomes plus PIP 2 , to determine unambiguous, state-dependent distances between paired Cys residues on diagonally opposite subunits. Functionality and pH dependence of our proteoliposome channels were verified in separate electrophysiological experiments. The lanthanide-based resonance energy transfer distances measured in closed (pH 6) and open (pH 8) conditions indicated neither expansion nor contraction of the CTD during gating, whereas the HBC gate widened by 8.8 ± 4 Å, from 6.3 ± 2 to 15.1 ± 6 Å, during opening. These results are consistent with a Kir gating model in which rigid body rotation of the large CTD around the permeation axis is correlated with opening of the HBC hydrophobic gate, allowing permeation of a 7 Å hydrated K ion. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

[Anatomical and clinical evaluation regarding the removal of the peritoneal dialysis catheter].

PubMed

Tăranu, T; Covic, A; Târcoveanu, E; Florea, Laura

2005-01-01

To describe CAPD technique survival and causes for catheter removal. The study included 320 end stage renal disease (ESRD) patients, initiated on CAPD between 1995-2003. Definitive catheter removal was required in 44 cases (15.1%), 11 of these (3.79%) receiving renal transplant. Causes for catheter removal were: mechanical obstruction by fibrin (8 cases/2.75%), obstruction by tub bower (1 case/0.34%), by omental muff (6 cases/2%); abdominal wall sepsis (30 cases/ 10.3%); non-responsive bacterial peritonitis (13 cases/4.05%), fungal peritonitis (7 cases/ 2.4%), fecal peritonitis (2 cases/0.68%); transfer to hemodialysis program (31 cases/10.6%); renal transplant (11 cases/3.79%); emergency surgical pathology for: necrotic-hemorrhagic pancreatitis (two cases), intestinal occlusions (six cases), locked hernias (three cases) and locked eventrations(three cases), appendicular peritonitis (two cases). Mortality associated with these procedures and underlying pathology was 1.73%.

Integrative Lifecourse and Genetic Analysis of Military Working Dogs

DTIC Science & Technology

2014-12-01

Award Number: W81XWH-11-2-0226 TITLE: Integrative Lifecourse and Genetic Analysis of Military Working Dogs PRINCIPAL INVESTIGATOR: Kun Huang...Integrative Lifecourse and Genetic Analysis of Military Working Dogs 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-2-0226 5c. PROGRAM ELEMENT NUMBER...of the military working dog population. There are several critical aspects to meeting the aims of this proposal. 1) development of data driven

Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial

DTIC Science & Technology

2016-03-01

AWARD NUMBER: W81XWH-11-2-0123 TITLE: Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial PRINCIPAL INVESTIGATOR: Dr...Caring Letters for Military Suicide Prevention: A Randomized 5a. CONTRACT NUMBER Controlled Trial 5b. GRANT NUMBER W81XWH-11-2-0123 5c. PROGRAM...determine if the intervention is effective in preventing suicide and suicidal behaviors among Service Members and Veterans. The “caring letters

Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial

DTIC Science & Technology

2017-03-01

AWARD NUMBER: W81XWH-11-2-0123 TITLE: Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial PRINCIPAL INVESTIGATOR: Dr...Caring Letters for Military Suicide Prevention: A Randomized 5a. CONTRACT NUMBER Controlled Trial 5b. GRANT NUMBER W81XWH-11-2-0123 5c. PROGRAM...determine if the intervention is effective in preventing suicide and suicidal behaviors among Service Members and Veterans. The “caring letters” concept

48 CFR 536.570-11 - Heat.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

48 CFR 536.570-11 - Heat.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

48 CFR 536.570-11 - Heat.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

48 CFR 536.570-11 - Heat.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

48 CFR 536.570-11 - Heat.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

48 CFR 11.702 - Construction contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Construction contracts. 11.702 Section 11.702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Variation in Quantity 11.702 Construction contracts. Construction...

48 CFR 11.702 - Construction contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Construction contracts. 11.702 Section 11.702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Variation in Quantity 11.702 Construction contracts. Construction...

48 CFR 11.702 - Construction contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Construction contracts. 11.702 Section 11.702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Variation in Quantity 11.702 Construction contracts. Construction...

48 CFR 11.702 - Construction contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Construction contracts. 11.702 Section 11.702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Variation in Quantity 11.702 Construction contracts. Construction...

Impacts of Stratospheric Dynamics on Atmospheric Behavior from the Ground to Space Solar Minimum and Solar Maximum

DTIC Science & Technology

2015-12-15

from the ground to space solar minimum and solar maximum 5a. CONTRACT NUMBER BAA-76-11-01 5b. GRANT NUMBER N00173-12-1G010 5c. PROGRAM ELEMENT...atmospheric behavior from the ground to space under solar minimum and solar maximum conditions (Contract No.: N00173-12-1-G010 NRL) Project Summary...Dynamical response to solar radiative forcing is a crucial and poorly understood mechanisms. We propose to study the impacts of large dynamical events

17 CFR 200.735-11 - Statement of employment and financial interests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulation Concerning... the Ethics in Government Act of 1978, Pub. L. 95-521. Members and such employees need not also file... Fellowship Programs. (iii) All employees engaged in any aspect of Government contracting or procurement...

The Industrial Base and National Security: A New Strategy

DTIC Science & Technology

1993-04-01

addresses this issue in her article entitled, " Managing Innovation on the Factory Floor": Manufacturing managers often buy the most advanced...Incentives Program." Government Contract Number MDA903-85-C-0139 Final Report, 1986. 31 11. Tyre, Marcie J. " Managing Innovation On The Factory Floor

7 CFR 1415.4 - Program requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., including the conservation, protection, enhancement, and, if necessary, restoration of the grassland... grazing management plan and any associated conservation plan or restoration agreement. (h) Easements and... conservation plan. (d) The easement or rental contract must grant USDA or its representatives a right of...

Cognitive and Neural Sciences Division 1990 Programs

DTIC Science & Technology

1990-08-01

operator skill acquisition for advanced manufacturing environments. In (W. Karawowski and M. Rahimi, Eds.) Ergonomics of Advanced Manufacturing and...PRINCIPAL INVESTIGATOR: John H. Maunsell University of Rochester Strong School of Medicine and Dentistry (716) 275-2076 R&T PROJECT CODE: 4424242 CONTRACT

Annual Letter Report on ONR (Office of Naval Research) Contract Number N00014-85-K-0228.

DTIC Science & Technology

1985-12-02

olefination, ".. and thioketalization, are currently under way. Stabilization of these polyketones _ with respect to aldolization is particularly important for...11 NaH High Dilution 67 ..- expected that a knotted polyketone will be especially prone to intramolecular trans-annular reactions. The four-rung THYME

42 CFR 52h.11 - What are the review criteria for contract projects and proposals?

Code of Federal Regulations, 2010 CFR

2010-10-01

... HUMAN SERVICES GRANTS SCIENTIFIC PEER REVIEW OF RESEARCH GRANT APPLICATIONS AND RESEARCH AND DEVELOPMENT... standpoint of the goals of the proposed research or development activity; (2) The availability of the... approach, the adequacy of the methodology to be utilized in carrying out the activity. (b) In carrying out...

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 10 (Germer Equipment Co-Hamilton Hilton National Wembley)

DTIC Science & Technology

1990-01-01

m’ 1) 00 00 00 m 1-r 0" ’m2 II ON ’r- - .- - C LOOcOaOC C> CC’m CI- t t mI ’U ’r 0(1 )0 - LN U L6 L, -4 0)C𔃼C𔃼( MPC4 C-’UN L 400 01-41 m2 T "O ’U 0

77 FR 5614 - Department of State FY11 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

... DEPARTMENT OF STATE [Public Notice 7785] Department of State FY11 Service Contract Inventory... Contract Inventory. SUMMARY: The Department of State has publically released its Service Contract Inventory for FY11 and its analysis of the FY10 inventory. They are available here: http://csm.state.gov...

The Army Study Program.

DTIC Science & Technology

1980-10-09

STUDDIES BY CATEGORY STUDY TITLE SPONSOR NMtTHOO PPA ADM RE:MOTE LINK PRUG DARCOM CONTRACT ADV TECH MODEL FULL DARCON CONTRACT ARMY COMMAND ANDi CONTROL...HOUUSE NUN -RLCURRIN 1 LMANUS DARCON I"-HUSL FF-TH-hLLI TM~k ECUNLNI(. ANALYSIS DARCOM CUNTRALT FOR SFELTKUM ANALYZERS UPLRA1IUN&L FLt)AI/EKPSL TKADL...TECHNULOGY A5 AESM:NT TRADOC bUTH *TEN YEAR INSTRUMENTATIOft ANALYSkIS OCSA ot" PHASE I TERRAIN MODELS DARCOM bUTH lEST CRITLRIA FUOR NUN -IIILLL-K WEAPUN

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 5 (Columbia Asphalt & Gravel Inc - Dela Tek Inc).

DTIC Science & Technology

1985-01-01

40 40 4000 1 O- 4 00 000 0 C 40 40 ca c 1- Q 4- - In In In o - In 0 co l. 40 l N N 𔃺 C)3 0 0N In In IN N I N I 𔃺’ D coca In4 Of4 I 4 W 4 W 1 NWWI. 4...1( n r- PP, - P - - - )0 00 awl-I qt0( Coo 0- -I41-- <- M (0 " 00000000mm) C 00 000 om- -1-4I I.NOI1)1) W1 ’. * * (0 .17 0000 -CM 0.3 0C4C - Coala Ow... coca r-. 4.-U, M LA4( 44( 0I NY NN4 NNic N N ( C) N (0" M (0 04o -44 3 4( 4 44 44 4d -C 4 33 4 -4(0 K m( -4 43l CK00 0) 00 00 0 0 0 00 0 0U 0)co C I

Guidelines clarify managed care accounting procedures.

PubMed

Cheramy, S J; Garner, M

1989-08-01

Two new documents offer guidance for accounting issues involved in managed care programs. The American Institute of Certified Public Accountants' Statement of Position 89-5 and HFMA's Principles and Practices Board Statement No. 11 address risk contracting from the perspective of the managed care program and the healthcare provider, respectively. One key issue addressed in the documents is the timing of expense recognition of the costs of providing health services to members of managed care plans.

Mobile Robot Enabled Detection of Explosives and Biological Agents

DTIC Science & Technology

2006-11-01

Detection of Explosives and Biological Agents 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e...TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Wayne State University, SSIM Program, Detroit, Michigan 48202 8...PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR

48 CFR 11.304 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 11.304 Section 11.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Acceptable Material 11.304 Contract clause. Insert the clause at 52.211-5, Material...

Graphene Oxide Annealing Procedures for Graphene-Based Supercapacitors

DTIC Science & Technology

2015-09-01

Annealing Procedures for Graphene-Based Supercapacitors by Louis B Levine and Matthew H Ervin Sensors and Electron Devices Directorate, ARL...SUBTITLE Graphene Oxide Annealing Procedures for Graphene-Based Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

The 2009 Influenza Pandemic: An Overview

DTIC Science & Technology

2009-08-06

36 See, for example, the figure by sanofi pasteur (a flu vaccine manufacturer), “A (H1N1) Vaccine ... vaccine antigen and adjuvant. The funds will be used to place additional orders for bulk H1N1 antigen and adjuvant on existing contracts with sanofi ...national stockpile; launched efforts to develop, manufacture, and test a vaccine ; and enabled waivers of liability and a compensation program in the

Beck PRIDE Center - An Effective Solution for Combat Injured Student Veterans

DTIC Science & Technology

2014-10-01

Award Number: W81XWH-11-1-0793 TITLE: Beck PRIDE Center – An Effective Solution for Combat Injured Student Veterans PRINCIPAL INVESTIGATOR: Dr...CONTRACT NUMBER Beck PRIDE Center – An Effective Solution for Combat Injured Student Veterans 5b. GRANT NUMBER W81XWH-11-1-0793 5c. PROGRAM ELEMENT...therapy including hippotherapy. Measures will be taken after each session and analyzed. 2) This study will also evaluate the impact of the Beck PRIDE

40 CFR 35.937-11 - Applicability to existing contracts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Applicability to existing contracts. 35.937-11 Section 35.937-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER... § 35.937-11 Applicability to existing contracts. Some negotiated engineering subagreements already in...

45 CFR 98.11 - Administration under contracts and agreements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Administration under contracts and agreements. 98.11 Section 98.11 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND General Application Procedures § 98.11 Administration under contracts and...

45 CFR 98.11 - Administration under contracts and agreements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Administration under contracts and agreements. 98.11 Section 98.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND General Application Procedures § 98.11 Administration under contracts and...

Novel Preclinical Testing Strategies for Treatment of Metastatic Pheochromocytoma

DTIC Science & Technology

2012-09-01

Treatment of Metastatic Pheochromocytoma PRINCIPAL INVESTIGATOR: Arthur S. Tischler...Treatment of Metastatic Pheochromocytoma 5a. CONTRACT NUMBER W81XWH-11-1-0670 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Pheochromocytomas (PCC) are catecholamine-producing neuroendocrine tumors. Up to 30% give

Time Synchronization in Wireless Sensor Networks

DTIC Science & Technology

2003-01-01

University of California Los Angeles Time Synchronization in Wireless Sensor Networks A dissertation submitted in partial satisfaction of the...4. TITLE AND SUBTITLE Time Synchronization in Wireless Sensor Networks 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...1 1.1 Wireless Sensor Networks . . . . . . . . . . . . . . . . . . . . . . 1 1.2 Time Synchronization in Sensor Networks

7 CFR 1735.77 - Release of loan funds, requisitions, advances.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-TELECOMMUNICATIONS PROGRAM Acquisitions Involving Loan Funds § 1735.77 Release of loan funds, requisitions, advances. (a) RUS will not approve the advance of loan funds until the borrower has fulfilled all loan contract... 7 Agriculture 11 2010-01-01 2010-01-01 false Release of loan funds, requisitions, advances. 1735...

26 CFR 1.401(a)(9)-6 - Required minimum distributions for defined benefit plans and annuity contracts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 2011 853,749 525,258 520,109 28,769 496,490 2012 806,053 506,419 501,454 29,034 477,385 2013 758,916... .95574 6 .92943 .04946 7 15,987 2011 8 .90847 .88517 .05519 14,807 2012 .85833 .84302 .06146 13,546 2013... 406,219 2012 806,053 414,343 410,281 23,755 390,588 2013 758,916 398,399 394,494 23,962 374,437 2014...

Review of Part 67 Of the Federal Air Regulations and the Medical Certification of Civilian Airmen. Volume 2

DTIC Science & Technology

1983-01-01

REVIEW OF PART 67 OF THE FEDERAL AIR REGULATIONS wIE AND THE MEDICAL CERTIFCATION OF CIVILIAN AnRI"N 0 A *1 DTIC D Submitted to the Federal Aviation...Administration under Contract #DTFAOI-83-C-Z0066 by the AAmerican Medical Association Alan L. Engelberg, MD, MPH, Project Director and Director...Technology LU Awcrican Medical Association 535 North Dearborn Street 4! ,-Chicago, Illinois- 60610 86 4 8 034 Table of Contents Volume I Foreword

Characterization of Defects in N-type 4H-SiC After High-Energy N Ion Implantation by RBS-Channeling and Raman Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kummari, Venkata C.; Reinert, Tilo; Jiang, Weilin

Implantation with 1 MeV N ions was performed at room temperature in n-type 4H-SiC(0001) to four implantation fluences (or doses in dpa (displacements per atom) at the damage peak) of 1.5×1013(0.0034), 7.8×1013(0.018), 1.5×1014(0.034), and 7.8×1014(0.18) ions/cm2, respectively. The evolution of disorder was studied using Rutherford backscattering spectrometry in channeling mode (RBS-C) and Raman spectroscopy. The disorder in the Si sub-lattice was found to be less than 10% for the dpa of 0.0034 and 0.0178 and increased to 40% and 60% for the dpa of 0.034 and 0.178 respectively. Raman Spectroscopy was performed using a green laser of wavelength 532 nmmore » as excitation source. The normalized Raman Intensity, In shows disorder of 41%, 69%, 77% and 100% for the dpa of 0.0034, 0.017, 0.034 and 0.178 respectively. In this paper, the characterizations of the defects produced due to the Nitrogen implantation in 4H-SiC are presented and the results are discussed.« less

The association between working hours and sleep disturbances according to occupation and gender.

PubMed

Kim, Bo Hwan; Lee, Hye-Eun

2015-01-01

We attempted to explore the relationship between working hours and sleep disturbance according to occupation and gender among Korean workers. Data were derived from the third Korean Working Conditions Survey, conducted in 2011 by the Korea Occupational Safety and Health Agency. From a total of 50,032 workers, 34,783 salaried contract workers were selected. Work hours were categorized as <40, 40-48 (reference), 49-60, and >60 h/week. The outcome variable was sleep disturbance, which was assessed by a single question item (During the past 12 months, have you experienced sleep disturbance or insomnia?). Multiple survey logistic regression models were performed after adjusting with age, education level, marital status, self-rated health, salary, shift work, smoking and alcohol drinking. Gender and occupation were stratified in these models. The adjusted odds ratio (OR) for sleep disturbance in male non-manual workers with long work hours (>60 h/week) was 3.017 [95% confidence interval (CI) 1.956-4.653]. In female non-manual workers who work 49-60 working hour per week, the OR was 1.525 (95% CI 1.034-2.249). Long working hours can be a risk factor for sleep disturbance in Korean workers. The association was especially prominent in male non-manual workers.

Navy Littoral Combat Ship (LCS) Program: Background and Issues for Congress

DTIC Science & Technology

2014-03-05

Earlier Press Reports That DOD Was Considering Truncating Program .......................... 16 February 24, 2014, Press Report About Navy Work on...the Navy’s decision (see “Manning and Deployment” above) to increase the size of the LCS core crew to about 50. A November 18, 2013, press report...2010. For a press article on this issue, see Cid Standifer, “FY-11 LCS Contracts On Hold Because Of Continuing Resolution,” Inside the Navy, March

Program and Management Support for the Office for Military Performance Assessment Technology

DTIC Science & Technology

1993-03-01

AD-A270 790 AD_ _ _ _ CONTRACT NO: DAMDI7-90-C-0061 TITLE: PROGRAM AND MANAGEMENT SUPPORT FOR THE OFFICE FOR MILITARY PERFORMANCE ASSESSMENT... the Office of Military Performance Assessment Technology (OMPAT). 1.1 Bag-kg n m. The OMPAT evolved from the Joint Working Group on Drug Dependent...facility was located, leased and occupied by Morgan Management Systems, Inc. staff and designated as the OMPAT Field Office. The office was located at 12075B

Mitochondrial Based Treatments that Prevent Post Traumatic Osteoarthritis in a Translational Large Animal Intraarticular Fracture Survival Model

DTIC Science & Technology

2015-09-01

AWARD NUMBER: W81XWH-11-1-0583 TITLE: “Mitochondrial-Based Treatments that Prevent Post-Traumatic Osteoarthritis in a Translational Large... Osteoarthritis in a Translational Large Animal Intraarticular Fracture Survival Model” 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0583 5c. PROGRAM...upon completion of the 6- and 12- month time points. 15. SUBJECT TERMS Post-traumatic osteoarthritis , oxidative stress, mitochondria, animal model 16

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 15 (Mountain States Caulking Inc-Pangborn Corp)

DTIC Science & Technology

1990-01-01

I 4 i (0> 0) (0 ?-- CoN 4C.A<>(0 0 9 3 020 i3f 04--4---0 -4 aNN C 0 VO N4 04000C0 33 3020 goN)L0(?-C 0 Of Co 0 ~ )0) 0)0) --- 03(3 C7(0 0)4 I3 3 02...M I -IO1 1 4NnInC0a laII0.I :Tl otIc 00o4-4 LIOr CO > -- 4-4 0-0-4 N m1 it-11m il C)I- o 00) 111 t 11 L- -4 0004 f Oi0 C ~ I -444- CON I NT N CL L...7) 0) I () 00 J! 0) 0)J 0. ) 0) 0) 0) .1  402 C 40 0 H 0 F- 0 0 H 344 if 2 I11-4" -I 0 a- 1- 1 0 0 444I CON 11I <- H < 044 : n 44 41 4cc 04E𔃺in

The effect of higher ATP cost of contraction on the metabolic response to graded exercise in patients with chronic obstructive pulmonary disease.

PubMed

Layec, Gwenael; Haseler, Luke J; Richardson, Russell S

2012-03-01

To better understand the metabolic implications of a higher ATP cost of contraction in chronic obstructive pulmonary disease (COPD), we used (31)P-magnetic resonance spectroscopy ((31)P-MRS) to examine muscle energetics and pH in response to graded exercise. Specifically, in six patients and six well-matched healthy controls, we determined the intracellular threshold for pH (T(pH)) and inorganic phosphate-to-phosphocreatine ratio (T(Pi/PCr)) during progressive dynamic plantar flexion exercise with work rate expressed as both absolute and relative intensity. Patients with COPD displayed a lower peak power output (WRmax) compared with controls (controls 25 ± 4 W, COPD 15 ± 5 W, P = 0.01) while end-exercise pH (controls 6.79 ± 0.15, COPD 6.76 ± 0.21, P = 0.87) and PCr consumption (controls 82 ± 10%, COPD 70 ± 18%, P = 0.26) were similar between groups. Both T(pH) and T(Pi/PCr) occurred at a significantly lower absolute work rate in patients with COPD compared with controls (controls: 14.7 ± 2.4 W for T(pH) and 15.3 ± 2.4 W for T(Pi/PCr); COPD: 9.7 ± 4.5 W for T(pH) and 10.0 ± 4.6 W for T(Pi/PCr), P < 0.05), but these thresholds occurred at the same percentage of WRmax (controls: 63 ± 11% WRmax for T(pH) and 67 ± 18% WRmax for T(Pi/PCr); COPD: 59 ± 9% WRmax for T(pH) and 61 ± 12% WRmax for T(Pi/PCr), P > 0.05). Indexes of mitochondrial function, the PCr recovery time constant (controls 42 ± 7 s, COPD 45 ± 11 s, P = 0.66) and the PCr resynthesis rate (controls 105 ± 21%/min, COPD 91 ± 31%/min, P = 0.43) were similar between groups. In combination, these results reveal that when energy demand is normalized to WRmax, as a consequence of higher ATP cost of contraction, patients with COPD display the same metabolic pattern as healthy subjects, suggesting that skeletal muscle energy production is well preserved in these patients.

Carbachol induces Ca(2+)-dependent contraction via muscarinic M2 and M3 receptors in rat intestinal subepithelial myofibroblasts.

PubMed

Iwanaga, Koichi; Murata, Takahisa; Okada, Muneyoshi; Hori, Masatoshi; Ozaki, Hiroshi

2009-07-01

Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine. Nerve endings distribute adjacent to IMFs, suggesting neurotransmitters may influence IMFs motility; however, there is no direct evidence showing the interaction. Here, we isolated IMFs from rat colon and investigated the effect of acetylcholine on IMFs contractility. In the collagen gel contraction assay, carbachol (1 - 10 microM) and the muscarinic receptor agonist bethanechol (30 - 300 microM) dose-dependently induced IMFs contraction. Pretreatment with the muscarinic receptor antagonist atropine (1 - 10 nM) inhibited carbachol-induced contraction. In RT-PCR, mRNA expression of all muscarinic receptor subtypes (M(1) - M(5)) was detected in IMFs. Subsequently we found pretreatment with the muscarinic M(2) receptor antagonist 11-([2-[(diethylamino)methyl]-1-piperdinyl]acetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one (AF-DX116) (10 and 30 nM) or the muscarinic M(3) receptor antagonist 4-diphenylacetoxy-N-methyl-piperidine (4-DAMP) (3 and 10 nM) dose-dependently inhibited carbachol-induced contraction. In Ca(2+) measurement, 1 - 10 microM carbachol and 30 - 300 microM bethanechol elevated the intracellular Ca(2+) concentration ([Ca(2+)](i)) in IMFs. Atropine (10 nM) eliminated carbachol-induced [Ca(2+)](i) elevation. The Ca(2+)-channel blocker LaCl(3) (3 microM) abolished carbachol-induced [Ca(2+)](i) elevation and contraction. Furthermore, AF-DX116 and 4-DAMP dose-dependently inhibited the carbachol-induced [Ca(2+)](i) elevation. These observations suggest that acetylcholine elicits Ca(2+)-dependent IMF contraction through muscarinic M(2) and M(3) receptors.

Navy Stock Point Local Unique Computer Programs: An Analysis for Transition and Management Under the Stock Point ADP Replacement (SPAR) Project.

DTIC Science & Technology

1987-03-01

Project (SPAR). An impor- tant issue of the replacement will be the conversion of existing co uter software to allow transition from the current... issue of the replacement will be the conversion of existing computer software to allow transition from the current hardware environment to the replacement...36 G. LOCAL PROGRAM C1/C2 CONVERSION CONTRACT . . . 38 5 H. LOCAL PROGRAM COMMONALITY ISSUES ....... 41 I. SUMMARY

Coal gasification systems engineering and analysis. Appendix H: Work breakdown structure

NASA Technical Reports Server (NTRS)

1980-01-01

A work breakdown structure (WBS) is presented which encompasses the multiple facets (hardware, software, services, and other tasks) of the coal gasification program. The WBS is shown to provide the basis for the following: management and control; cost estimating; budgeting and reporting; scheduling activities; organizational structuring; specification tree generation; weight allocation and control; procurement and contracting activities; and serves as a tool for program evaluation.

Sepsis attenuates the anabolic response to skeletal muscle contraction

PubMed Central

Steiner, Jennifer L.; Lang, Charles H.

2014-01-01

Electrically stimulated muscle contraction is a potential clinical therapy to treat sepsis-induced myopathy; however, whether sepsis alters contraction-induced anabolic signaling is unknown. Polymicrobial peritonitis was produced by cecal ligation and puncture (CLP) in male C57BL/6 mice and time-matched, pair-fed controls (CON). At ~24 h post-CLP, the right hindlimb was electrically stimulated via the sciatic nerve to evoke maximal muscle contractions and the gastrocnemius was collected 2 h later. Protein synthesis was increased by muscle contraction in CON mice. Sepsis suppressed the rate of synthesis in both the non-stimulated (31%) and stimulated (57%) muscle versus CON. Contraction of muscle in CON mice increased the phosphorylation of mTORC1 substrates S6K1 Thr389 (8-fold), S6K1 Thr421/Ser424 (7-fold) and 4E-BP1 Ser65 (11-fold). Sepsis blunted the contraction-induced phosphorylation of S6K1 Thr389 (67%), S6K1 Thr421/Ser424 (46%) and 4E-BP1 Ser65 (85%). Conversely, sepsis did not appear to modulate protein elongation as eEF2 Thr56 phosphorylation was decreased similarly by muscle contraction in both groups. MAPK signaling was discordant following muscle contraction in septic muscle; phosphorylation of ERK Thr202/Tyr204 and p38 Thr180/Tyr182 was increased similarly in both CON and CLP mice while sepsis prevented the contraction-induced phosphorylation of JNK Thr183/Tyr185 and c-JUN Ser63. The expression of IL-6 and TNF-α mRNA in muscle was increased by sepsis, and contraction increased TNF-α to a greater extent in muscle from septic than CON mice. Injection of the mTOR inhibitor Torin2 in separate mice confirmed that contraction-induced increases in S6K1 and 4E-BP1 were mTOR-mediated. These findings demonstrate that resistance to contraction-induced anabolic signaling occurs during sepsis and is predominantly mTORC1-dependent. PMID:25423127

Sepsis attenuates the anabolic response to skeletal muscle contraction.

PubMed

Steiner, Jennifer L; Lang, Charles H

2015-04-01

Electrically stimulated muscle contraction is a potential clinical therapy to treat sepsis-induced myopathy; however, whether sepsis alters contraction-induced anabolic signaling is unknown. Polymicrobial peritonitis was produced by cecal ligation and puncture (CLP) in male C57BL/6 mice and time-matched, pair-fed controls (CON). At ∼24 h post-CLP, the right hindlimb was electrically stimulated via the sciatic nerve to evoke maximal muscle contractions, and the gastrocnemius was collected 2 h later. Protein synthesis was increased by muscle contraction in CON mice. Sepsis suppressed the rate of synthesis in both the nonstimulated (31%) and stimulated (57%) muscle versus CON. Contraction of muscle in CON mice increased the phosphorylation of mTORC1 (mammalian target of rapamycin [mTOR] complex 1) substrates S6K1 (70-kd ribosomal protein S6 kinase 1) Thr (8-fold), S6K1 ThrSer (7-fold) and 4E-BP1 Ser (11-fold). Sepsis blunted the contraction-induced phosphorylation of S6K1 Thr (67%), S6K1 ThrSer (46%), and 4E-BP1 Ser (85%). Conversely, sepsis did not appear to modulate protein elongation as eEF2 Thr phosphorylation was decreased similarly by muscle contraction in both groups. Mitogen-activated protein kinase signaling was discordant following contraction in septic muscle; phosphorylation of extracellular signal-regulated kinase ThrTyr and p38 ThrTyr was increased similarly in both CON and CLP mice, while sepsis prevented the contraction-induced phosphorylation of JNK ThrTyr and c-JUN Ser. The expression of interleukin 6 and tumor necrosis factor α (TNF-α) mRNA in muscle was increased by sepsis, and contraction increased TNF-α to a greater extent in muscle from septic than CON mice. Injection of the mTOR inhibitor Torin2 in separate mice confirmed that contraction-induced increases in S6K1 and 4E-BP1 were mTOR mediated. These findings demonstrate that resistance to contraction-induced anabolic signaling occurs during sepsis and is predominantly mTORC1-dependent.

48 CFR 301.607-78 - Contracting Officer designation of a Program/Project Manager as the Contracting Officer's...

Code of Federal Regulations, 2010 CFR

2010-10-01

... designation of a Program/Project Manager as the Contracting Officer's Technical Representative. 301.607-78... Contracting Officer designation of a Program/Project Manager as the Contracting Officer's Technical... acquisition. However, for those individuals serving as a Program or Project Manager under a FAC-P/PM...

Competitive On-Line Scheduling for Overloaded Real-Time Systems

DTIC Science & Technology

1993-09-01

Real - Time Systems by Gilad Koren a dissertation submitted in partial fulfillment of the requirements...Overloaded Real - Time Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...1.1 Introduction : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 2 1.1.1 Real - Time Systems : : : : : : : : : : : : : : : : : : : : : : : : : : : :

The Fate of Intrapleurally Injected Bone Marrow-Derived Stem Cells in Mice with Pleural Mesothelioma

DTIC Science & Technology

2012-12-01

hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep . Hepatology, 46: 1935-1945, 2007. 4. Jongsma, J., van...Mice with Pleural Mesothelioma 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0574 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jonathan M

Program Monitoring: The Role of Leadership in Planning, Assessment, and Communication. REL 2014-034

ERIC Educational Resources Information Center

Malone, Nolan; Narayan, Krishna; Mark, Lauren; Miller, Kirsten; Kekahio, Wendy

2014-01-01

As educators are increasingly called on to use data to inform improvement initiatives (and are being held accountable for doing so), there is a corresponding need for program leaders to monitor progress. Program monitoring--the systematic and continual observation and recording of key program aspects--can provide leaders with realistic assessments…

Effect of the temperature, pH and irradiance on the photosynthetic activity by Scenedesmus obtusiusculus under nitrogen replete and deplete conditions.

PubMed

Cabello, Juan; Toledo-Cervantes, Alma; Sánchez, León; Revah, Sergio; Morales, Marcia

2015-04-01

This paper evaluates the effect of the irradiance, pH and temperature on the photosynthetic activity (PA) of Scenedesmus obtusiusculus under N-replete and N-deplete conditions through oxygen measurements. The highest PA values were 160 mgO2 gb(-1) h(-1) at 620 μmol m(-2) s(-1), 35 °C and pH of 8 under N-replete conditions and 3.3 mgO2 gb(-1) h(-1) at 100 μmol m(-2) s(-1), 28.5 °C and pH of 5.5 for N-deplete conditions. Those operation conditions were tested in a flat-panel photobioreactor. The biomass productivity was 0.97 gb L(-1) d(-1) under N-replete conditions with a photosynthetic efficiency (PE) of 4.4% yielding 0.85 gb mol photon(-1). Similar biomass productivity was obtained under N-deplete condition; and the lipid productivity was 0.34 gL L(-1) d(-1) with a PE of 7.8% yielding 0.39 gL mol photon(-1). The apparent activation and deactivation energies were 16.1 and 30 kcal mol(-1), and 11.9 and 15.3 kcal mol(-1), for N-replete and N-deplete conditions, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Paperless Contract Folder’s (PCF) DoD 5015.2 Certification

DTIC Science & Technology

2010-06-01

Draft Version Controls ...........................................................11 i. Electronic Routing of Purchase Request (Funding) Documents...of electronic records, version control , robust search and retrieval, and automated disposition that is compliant with legal requirements. As shown...h. Draft Version Controls Draft and versioning controls track the changes to the documents once they are saved. Draft numbers (0.1, 0.2, 0.3

Analysis of Minuteman Missile Crew Member Attitudes Toward Present Minuteman Education Program and Possible Alternatives.

DTIC Science & Technology

1980-06-01

TO0WARD PRESLT NUE N - DUCATION PROGRADF AND T0SMBLE 6. PERFORMING GIG. 0114:00RT NUMneRt 11. CONTRACT ORt GRANT NuUSERf(s1 t~ Donald L. i emp Captain...USAF, M4SC *Andrew T.//Rybacr Captain, USAF 9. PERFORMING ORGANIZATION NAME AND AOORES~r10 PROGRAM ELEMENT. PROJECT. TASK School of Systems and...106 38. MMEP IMPROVES DUTY PERFORMANCE (X2 One Sample Test) .. .......... . 107 39. MMEP IMPROVES DUTY PERFORMANCE (Questionnaire Data

Adjoint-Free Variational Data Assimilation into a Regional Wave Model

DTIC Science & Technology

2015-07-01

Wave Model 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER...developed by Oceanweather, Inc. using the methodology of Cardone et al. (1995, 1996). The winds were taken for the period 11–20 September 2011 and...International Arctic Research Center, NSF Grants 1107925 and 1203740. It was also supported by theOffice of Naval Research (Program Element 0602435N, pro

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Leventhal Bros & Co. Inc. - Martinez A M Construction)

DTIC Science & Technology

1994-03-01

cacau u uIn t c o 3I ac a uu ~In uuuu t aac nu nuCLn wmu u nu wu uu u mm wu II I CO -4eNI 01 - -4---4 -- 4-4-4 4-4 - 4 44------4-4 w4-4-4-4----q-4 ý...4NOH 00 0 0 0 0 0 00 0 0 000 0 If Cg) -4NmlI aWit 11 C -04N( goH .-4-4 ON 01 a) a) a) 010 07111 cc -4 N a H (n1 n U 4 u cc Go :1 (A CACAU (11 (0.- CiN 41

Army Contract Writing System (ACWS)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Army Contract Writing System (ACWS) Defense Acquisition Management Information Retrieval...Program Information Program Name Army Contract Writing System (ACWS) DoD Component Army Responsible Office Program Manager References MAIS...UNCLASSIFIED 4 Program Description The Army Contract Writing System (ACWS) will be the Army’s single, next-generation, enterprise-wide contract writing

Core Muscle Activation During Unstable Bicep Curl Using a Water-Filled Instability Training Tube.

PubMed

Glass, Stephen C; Blanchette, Taylor W; Karwan, Lauren A; Pearson, Spencer S; OʼNeil, Allison P; Karlik, Dustin A

2016-11-01

Glass, SC, Blanchette, TW, Karwan, LA, Pearson, SS, O'Neil, AP, and Karlik, DA. Core muscle activation during unstable bicep curl using a water-filled instability training tube. J Strength Cond Res 30(11): 3212-3219, 2016-The purpose of this study was to assess compensatory muscle activation created during a bicep curl using a water-filled, unstable lifting tube. Ten men (age = 21 ± 1.6 years, height = 180.0 ± 3.3 cm, mass = 87.4 ± 15.0 kg) and 10 women (age = 19.6 ± 1.3 years, height = 161.4 ± 12.0 cm, mass = 61.2 ± 7.4 kg) completed bicep curls using an 11.4-kg tube partially filled with water during a 50% open-valve, 100% open, and control setting. Subjects completed 8 repetitions within each condition with integrated electromyographic signal (converted to percent maximal voluntary contraction) of the bicep, deltoid, rectus abdominus, and paraspinal muscles measured. Compensatory activation was determined using the natural log of coefficient of variation across concentric (CON) and eccentric (ECC) contractions. There were no differences between gender for any condition. Significant variability was seen across treatments for paraspinal muscles for CON and ECC at 50% (CON LnCV = 3.13 ± 0.56%, ECC LnCV = 3.34 ± 0.58%) and 100% (CON = 3.24 ± 0.34%, ECC = 3.46 ± 0.35%) compared with control (CON = 2.59 ± 0.47%, ECC = 2.80 ± 0.61%). Deltoid variability was greater at the 100% open setting (CON = 3.51 ± 0.53%, ECC = 3.56 ± 0.36%) compared with control (CON = 2.98 ± 0.35%, ECC = 2.97 ± 0.45%). The abdominal CON 100% showed variability (3.02 ± 0.47%) compared with control (2.65 ± 0.43%). Bicep activation remained unvaried. Compensatory activation of postural muscles contribute to postural stability. This device may be a useful tool for neuromuscular training leading to improved stability and control.

Changes in Ovarian Stromal Function and Associated Symptoms in Premenopausal Women Undergoing Chemotherapy for Breast Cancer

DTIC Science & Technology

2008-08-01

Reynolds CA, Hartmann LC. Stratification of breast cancer risk in women with atypia : A Mayo cohort study. Journal of Clinical Oncology. 2007;25... Breast Cancer PRINCIPAL INVESTIGATOR: Marlene H. Frost, RN, Ph.D. CONTRACTING ORGANIZATION...Chemotherapy for Breast Cancer 5b. GRANT NUMBER DAMD17-03-1-0593 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Frost, Marlene H., RN, Ph.D 5d. PROJECT

Production of ethanol and arabitol by Debaryomyces nepalensis: influence of process parameters

PubMed Central

2013-01-01

Debaryomyces nepalensis, osmotolerant yeast isolated from rotten apple, is known to utilize both hexoses and pentoses and produce industrially important metabolites like ethanol, xylitol and arabitol. In the present study, the effect of different growth substrates, trace elements, nitrogen concentration and initial pH on growth and formation of ethanol and arabitol were examined. Optimum conditions for maximizing the product yields were established: glucose as carbon source, an initial pH of 6.0, 6 g/L of ammonium sulphate and addition of micronutrients. Under these best suited conditions, a concentration of 11g/L of arabitol and 19 g/L of ethanol was obtained in shake flask fermentations. The fermentation was scaled up to 2.5 L bioreactor and the influence of aeration, agitation and initial substrate concentration was also determined. Under optimal conditions (150 g/L glucose, 400 rpm and 0.5 vvm) ethanol concentration reached 52 g/L, which corresponds to a yield of 0.34 g/g and volumetric productivity of 0.28 g/L/h, whereas arabitol production reached a maximum of 14 g/L with a yield and volumetric productivity of 0.1 g/g and 0.07 g/L/h respectively. PMID:23659479

Acute whole-body vibration increases reciprocal inhibition.

PubMed

Ritzmann, Ramona; Krause, Anne; Freyler, Kathrin; Gollhofer, Albert

2018-06-26

Based on previous evidence that whole-body vibration (WBV) affects pathways involved in disynaptic reciprocal inhibition (DRI), the present hypothesis-driven experiment aimed to assess the acute effects of WBV on DRI and co-contraction. DRI from ankle dorsiflexors to plantar flexors was investigated during submaximal dorsiflexion before and after 1 min of WBV. With electromyography, musculus soleus (SOL) H-reflex depression following a conditioning stimulation of the peroneal nerve (1.1x motor threshold for the musculus tibialis anterior, TA) was assessed and co-contraction was calculated. After WBV, DRI was significantly increased (+4%, p < 0.05). SOL (-13%, p < 0.05) and TA (-6%, p < 0.05) activities were significantly reduced; co-contraction tended to be diminished (-8%, p = 0.05). Dorsiflexion torque remained unchanged. After WBV, DRI increased during submaximal isometric contraction in healthy subjects. The simultaneous SOL relaxation and TA contraction indicate that a more economic movement execution is of functional significance for WBV application in clinical and athletic treatment. Copyright © 2018 Elsevier B.V. All rights reserved.

Low-level laser therapy (LLLT) attenuates RhoA mRNA expression in the rat bronchi smooth muscle exposed to tumor necrosis factor-alpha.

PubMed

de Lima, Flávia Mafra; Bjordal, Jan M; Albertini, Regiane; Santos, Fábio V; Aimbire, Flavio

2010-09-01

Low-level laser therapy (LLLT) has been found to produce anti-inflammatory effects in a variety of disorders. Bronchial smooth muscle (BSM) hyperreactivity is associated with increased Ca+2 sensitivity and increased RhoA mRNA expression. In the current study, we investigated if LLLT could reduce BSM contraction force and RhoA mRNA expression in tumor necrosis factor-alpha (TNF-alpha)-induced BSM hyperreactivity. In the study, 112 male Wistar rats were divided randomly into 16 groups, and BSM was harvested and suspended in TNF-alpha baths for 6 and 24 h, respectively. Irradiation with LLLT was performed with a wavelength of 660 nm for 42 s with a dose of 1.3 J/cm2. This LLLT dose was administered once in the 6-h group and twice in the 24-h group. LLLT significantly decreased contraction force in BSM at 6 h (TNF-alpha + LLLT: 11.65+/-1.10 g/100 mg of tissue) (F=3115) and at 24 h (TNF-alpha+ LLLT: 14.15+/-1.1 g/100 mg of tissue) (F=3245, p<0.05) after TNF-alpha, respectively, when compared to vehicle-bathed groups (control). LLLT also significantly decreased the expression of RhoA mRNA in BSM segments at 6 h (1.22+/-0.20) (F=2820, p<0.05) and 24 h (2.13+/-0.20) (F=3324, p<0.05) when compared to BSM segments incubated with TNF-alpha without LLLT irradiation. We conclude that LLLT administered with this protocol, reduces RhoA mRNA expression and BSM contraction force in TNF-alpha-induced BSM hyperreactivity.

Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2.

PubMed

Qu, Chen; Leung, Susan W S; Vanhoutte, Paul M; Man, Ricky Y K

2010-08-01

Acute inhibition of nitric-oxide synthase (NOS) unmasks the release of endothelium-derived contracting factors (EDCFs). The present study investigated whether chronic inhibition of NOS modulates endothelium-dependent contractions. Eighteen-week-old male Sprague-Dawley rats were treated by daily gavage for 6 weeks with the NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) (60 mg/kg) or vehicle (distilled water; 1 ml/kg). Chronic treatment with L-NAME increased arterial blood pressure. Isometric tension was measured in aortic rings with or without endothelium. Endothelium-dependent relaxations to acetylcholine and the calcium ionophore 5-(methylamino)-2-[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid (A23187) were reduced in preparations from L-NAME-treated rats. The reduction in relaxation to A23187 was partially reversed by L-arginine (1 mM). In quiescent aortic rings, A23187 caused contractions in the presence of L-NAME and intact endothelium. The A23187-induced contractions were greater in rings from the L-NAME-treated rats than in those from the control group. These contractions were abolished by the cyclooxygenase (COX)-2 inhibitor N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide (NS-398) and the thromboxane-prostanoid (TP) receptor antagonist 3-((6R)-6-{[(4-chlorophenyl)sulfonyl]amido}-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate (S18886), but not by the COX-1 inhibitor 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole (SC-560). Chronic L-NAME treatment reduced the level of nitric oxide in the plasma but increased COX activity in the aortic rings. Western blotting and immunohistochemical staining showed that endothelial NOS expression was reduced in the aortae of the chronic L-NAME-treated group. COX-1 expression was augmented slightly, whereas COX-2 expression was up-regulated markedly. The TP receptor expression was comparable with control. These experiments demonstrate that chronic NOS inhibition increases endothelium-dependent contractions of the rat aorta by inducing COX-2 expression and augmenting the production of EDCF.

Extracellular acidosis selectively inhibits pharmacomechanical coupling induced by carbachol in strips of rat gastric fundus.

PubMed

de Oliveira, Daniel Maia Nogueira; Batista-Lima, Francisco José; de Carvalho, Emanuella Feitosa; Havt, Alexandre; da Silva, Moisés Tolentino Bento; Dos Santos, Armênio Aguiar; Magalhães, Pedro Jorge Caldas

2017-12-01

What is the central question of this study? Acute acidosis that results from short-term exercise is involved in delayed gastric emptying in rats and the lower responsiveness of gastric fundus strips to carbachol. Does extracellular acidosis decrease responsiveness to carbachol in tissues of sedentary rats? How? What is the main finding and its importance? Extracellular acidosis inhibits cholinergic signalling in the rat gastric fundus by selectively influencing the G q/11 protein signalling pathway. Acute acidosis that results from short-term exercise delays gastric emptying in rats and decreases the responsiveness to carbachol in gastric fundus strips. The regulation of cytosolic Ca 2+ concentrations appears to be a mechanism of action of acidosis. The present study investigated the way in which acidosis interferes with gastric smooth muscle contractions. Rat gastric fundus isolated strips at pH 6.0 presented a lower magnitude of carbachol-induced contractions compared with preparations at pH 7.4. This lower magnitude was absent in carbachol-stimulated duodenum and KCl-stimulated gastric fundus strips. In Ca 2+ -free conditions, repeated contractions that were induced by carbachol progressively decreased, with no influence of extracellular pH. In fundus strips, CaCl 2 -induced contractions were lower at pH 6.0 than at pH 7.4 but only when stimulated in the combined presence of carbachol and verapamil. In contrast, verapamil-sensitive contractions that were induced by CaCl 2 in the presence of KCl did not change with pH acidification. In Ca 2+ store-depleted preparations that were treated with thapsigargin, the contractions that were induced by extracellular Ca 2+ restoration were smaller at pH 6.0 than at pH 7.4, but relaxation that was induced by SKF-96365 (an inhibitor of store-operated Ca 2+ entry) was unaltered by extracellular acidification. At pH 6.0, the phospholipase C inhibitor U-73122 relaxed carbachol-induced contractions less than at pH 7.4, and this phenomenon was absent in tissue that was treated with the RhoA kinase blocker Y-27632. Thus, extracellular acidosis inhibited pharmacomechanical coupling in gastric fundus by selectively inhibiting the G q/11 protein signalling pathway, whereas electromechanical coupling remained functionally preserved. © 2017 The Authors. Experimental Physiology © 2017 The Physiological Society.

Environment, Safety, and Health Self-Assessment Report, Fiscal Year 2008

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chernowski, John

2009-02-27

Lawrence Berkeley National Laboratory's Environment, Safety, and Health (ES&H) Self-Assessment Program ensures that Integrated Safety Management (ISM) is implemented institutionally and by all divisions. The Self-Assessment Program, managed by the Office of Contract Assurance (OCA), provides for an internal evaluation of all ES&H programs and systems at LBNL. The functions of the program are to ensure that work is conducted safely, and with minimal negative impact to workers, the public, and the environment. The Self-Assessment Program is also the mechanism used to institute continuous improvements to the Laboratory's ES&H programs. The program is described in LBNL/PUB 5344, Environment, Safety, andmore » Health Self-Assessment Program and is composed of four distinct assessments: the Division Self-Assessment, the Management of Environment, Safety, and Health (MESH) review, ES&H Technical Assurance, and the Appendix B Self-Assessment. The Division Self-Assessment uses the five core functions and seven guiding principles of ISM as the basis of evaluation. Metrics are created to measure performance in fulfilling ISM core functions and guiding principles, as well as promoting compliance with applicable regulations. The five core functions of ISM are as follows: (1) Define the Scope of Work; (2) Identify and Analyze Hazards; (3) Control the Hazards; (4) Perform the Work; and (5) Feedback and Improvement. The seven guiding principles of ISM are as follows: (1) Line Management Responsibility for ES&H; (2) Clear Roles and Responsibilities; (3) Competence Commensurate with Responsibilities; (4) Balanced Priorities; (5) Identification of ES&H Standards and Requirements; (6) Hazard Controls Tailored to the Work Performed; and (7) Operations Authorization. Performance indicators are developed by consensus with OCA, representatives from each division, and Environment, Health, and Safety (EH&S) Division program managers. Line management of each division performs the Division Self-Assessment annually. The primary focus of the review is workplace safety. The MESH review is an evaluation of division management of ES&H in its research and operations, focusing on implementation and effectiveness of the division's ISM plan. It is a peer review performed by members of the LBNL Safety Review Committee (SRC), with staff support from OCA. Each division receives a MESH review every two to four years, depending on the results of the previous review. The ES&H Technical Assurance Program (TAP) provides the framework for systematic reviews of ES&H programs and processes. The intent of ES&H Technical Assurance assessments is to provide assurance that ES&H programs and processes comply with their guiding regulations, are effective, and are properly implemented by LBNL divisions. The Appendix B Performance Evaluation and Measurement Plan (PEMP) requires that LBNL sustain and enhance the effectiveness of integrated safety, health, and environmental protection through a strong and well-deployed system. Information required for Appendix B is provided by EH&S Division functional managers. The annual Appendix B report is submitted at the close of the fiscal year. This assessment is the Department of Energy's (DOE) primary mechanism for evaluating LBNL's contract performance in ISM.« less

Mg, Al, Si, Ca, Ti, Fe, and Ni abundance for a sample of solar analogues

NASA Astrophysics Data System (ADS)

López-Valdivia, Ricardo; Bertone, Emanuele; Chávez, Miguel

2017-05-01

We report on the determination of chemical abundances of 38 solar analogues, including 11 objects previously identified as super-metal-rich stars. We have measured the equivalent widths for 34 lines of 7 different chemical elements (Mg, Al, Si, Ca, Ti, Fe and Ni) in high-resolution (R ˜ 80 000) spectroscopic images, obtained at the Observatorio Astrofísico Guillermo Haro (Sonora, Mexico), with the Cananea High-resolution Spectrograph. We derived chemical abundances using atlas12 model atmospheres and the Fortran code moog. We confirmed the super-metallicity status of six solar analogues. Within our sample, BD+60 600 is the most metal rich star ([Fe/H] = +0.35 dex), while for HD 166991, we obtained the lowest iron abundance ([Fe/H] = -0.53 dex). We also computed the so-called [Ref] index for 25 of our solar analogues, and we found that BD+60 600 ([Ref] = +0.42) and BD+28 3198 ([Ref] = +0.34) are good targets for exoplanet search.

Water Processor and Oxygen Generation Assembly

NASA Technical Reports Server (NTRS)

Bedard, John

1997-01-01

This report documents the results of the tasks which initiated efforts on design issues relating to the Water Processor (WP) and the Oxygen Generation Assembly (OGA) Flight Hardware for the International Space Station. This report fulfills the Statement of Work deliverables requirement for contract H-29387D. The following lists the tasks required by contract H-29387D: (1) HSSSI shall coordinate a detailed review of WP/OGA Flight Hardware program requirements with personnel from MSFC to identify requirements that can be eliminated without affecting the technical integrity of the WP/OGA Hardware; (2) HSSSI shall conduct the technical interchanges with personnel from MSFC to resolve design issues related to WP/OGA Flight Hardware; (3) HSSSI will initiate discussions with Zellwegger Analytics, Inc. to address design issues related to WP and PCWQM interfaces.

Relationship between isometric contraction intensity and muscle hardness assessed by ultrasound strain elastography.

PubMed

Inami, Takayuki; Tsujimura, Toru; Shimizu, Takuya; Watanabe, Takemasa; Lau, Wing Yin; Nosaka, Kazunori

2017-05-01

Ultrasound elastography is used to assess muscle hardness or stiffness; however, no previous studies have validated muscle hardness measures using ultrasound strain elastography (SE). This study investigated the relationship between plantar flexor isometric contraction intensity and gastrocnemius hardness assessed by SE. We hypothesised that the muscle would become harder linearly with an increase in the contraction intensity of the plantar flexors. Fifteen young women (20.1 ± 0.8 years) performed isometric contractions of the ankle plantar flexors at four different intensities (25, 50, 75, 100% of maximal voluntary contraction force: MVC) at 0° plantar flexion. Using SE images, the strain ratio (SR) between the muscle and an acoustic coupler (elastic modulus 22.6 kPa) placed over the skin was calculated (muscle/coupler); pennation angle and muscle thickness were measured for the resting and contracting conditions. SR decreased with increasing contraction intensity from rest (1.28 ± 0.20) to 25% (0.99 ± 0.21), 50% (0.61 ± 0.15), 75% (0.34 ± 0.1) and 100% MVC (0.20 ± 0.05). SR decreased linearly (P < 0.05) with increasing MVC from rest to 75% MVC, but levelled off from 75 and 100% MVC. SR was negatively correlated with pennation angle (r = -0.80, P < 0.01) and muscle thickness ( r= -0.78,  P< 0.01). SR appears to represent muscle hardness changes in response to contraction intensity changes, in the assumption that the gastrocnemius muscle contraction intensity is proportional to the plantar flexion intensity. We concluded that gastrocnemius muscle hardness changes could be validly assessed by SR, and the force-hardness relationship was not linear.

Age-related differences in twitch properties and muscle activation of the first dorsal interosseous.

PubMed

Miller, Jonathan D; Herda, Trent J; Trevino, Michael A; Sterczala, Adam J; Ciccone, Anthony B; Nicoll, Justin X

2017-06-01

To examine twitch force potentiation and twitch contraction duration, as well as electromyographic amplitude (EMG RMS ) and motor unit mean firing rates (MFR) at targeted forces between young and old individuals in the first dorsal interosseous (FDI). Ultrasonography was used to assess muscle quality. Twenty-two young (YG) (age=22.6±2.7years) and 14 older (OD) (age=62.1±4.7years) individuals completed conditioning contractions at 10% and 50% maximal voluntary contraction, (MVC) during which EMG RMS and MFRs were assessed. Evoked twitches preceded and followed the conditioning contractions. Ultrasound images were taken to quantify muscle quality (cross-sectional area [CSA] and echo intensity [EI]). No differences were found between young and old for CSA, pre-conditioning contraction twitch force, or MFRs (P>0.05). However, OD individuals exhibited greater EI and contraction duration (P<0.05), and EMG RMS (YG=35.4±8.7%, OD=43.4±13.2%; P=0.034). Twitch force potentiation was lower for OD (0.311±0.15N) than YG (0.619±0.26N) from pre- to post-50% conditioning contraction (P<0.001). Lower levels of potentiation with elongated contraction durations likely contributed to greater muscle activation during the conditioning contractions in the OD rather than altered MFRs. Ultrasonography suggested age-related changes in muscle structure contributed to altered contractile properties in the OD. Greater muscle activation requirements can have negative implications on fatigue resistance at low to moderate intensities in older individuals. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Development of Diagnostics for the Livermore DPF Devices

NASA Astrophysics Data System (ADS)

Mitrani, James; Prasad, Rahul R.; Podpaly, Yuri A.; Cooper, Christopher M.; Chapman, Steven F.; Shaw, Brian H.; Povilus, Alexander P.; Schmidt, Andrea

2017-10-01

LLNL is commissioning several new diagnostics to understand and optimize ion and neutron production in their dense plasma focus (DPF) systems. Gas fills used in DPF devices at LLNL are Deuterium (D2) and He accelerated onto a Be target, for production of neutrons. Neutron yields are currently measured with Helium-3 tubes, and development of yttrium-based activation detectors is currently underway. Neutron time-of-flight (nTOF) signals from prompt neutrons will be measured with gadolinium-doped liquid scintillators. An ion energy analyzer will be used to diagnose energy distribution of D + and He +2 ions. Additionally, a fast frame ICCD camera has been applied to image the plasma sheath during the rundown and pinch phases. Sheath velocity will be measured with an array of discrete photodiodes with ns time responses. A discussion of our results will be presented. Prepared by LLNL under Contract DE-AC52-07NA27344, and supported by the Laboratory Directed Research and Development Program (15-ERD-034) at LLNL and the Office of Defense Nuclear Nonproliferation Research and Development within U.S. Department of Energy.

Grid Stiffened Structure Analysis Tool

NASA Technical Reports Server (NTRS)

1999-01-01

The Grid Stiffened Analysis Tool contract is contract performed by Boeing under NASA purchase order H30249D. The contract calls for a "best effort" study comprised of two tasks: (1) Create documentation for a composite grid-stiffened structure analysis tool, in the form of a Microsoft EXCEL spread sheet, that was developed by originally at Stanford University and later further developed by the Air Force, and (2) Write a program that functions as a NASTRAN pre-processor to generate an FEM code for grid-stiffened structure. In performing this contract, Task 1 was given higher priority because it enables NASA to make efficient use of a unique tool they already have; Task 2 was proposed by Boeing because it also would be beneficial to the analysis of composite grid-stiffened structures, specifically in generating models for preliminary design studies. The contract is now complete, this package includes copies of the user's documentation for Task 1 and a CD ROM & diskette with an electronic copy of the user's documentation and an updated version of the "GRID 99" spreadsheet.

42 CFR 52h.10 - What matters must be reviewed for solicited contract proposals?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false What matters must be reviewed for solicited contract proposals? 52h.10 Section 52h.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... CONTRACT PROJECTS § 52h.10 What matters must be reviewed for solicited contract proposals? (a) Subject to...

17 CFR 156.3 - Contract market program for enforcement.

Code of Federal Regulations, 2014 CFR

2014-04-01

... for potential abuse and to secure compliance with all other contract market bylaws, rules, regulations... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Contract market program for... (CONTINUED) BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as...

17 CFR 156.3 - Contract market program for enforcement.

Code of Federal Regulations, 2013 CFR

2013-04-01

... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of...

17 CFR 156.3 - Contract market program for enforcement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of...

17 CFR 156.3 - Contract market program for enforcement.

Code of Federal Regulations, 2012 CFR

2012-04-01

... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of...

17 CFR 156.3 - Contract market program for enforcement.

Code of Federal Regulations, 2011 CFR

2011-04-01

... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of...

Work Breakdown Structure (WBS) and WBS dictionary. [advanced x ray astrophysics facility (AXAF)

NASA Technical Reports Server (NTRS)

Cocuzzo, F.

1994-01-01

This document is intended to provide the framework for defining all work to be accomplished under the proposed contract for the mission support program as defined by Section J-1 Statement of Work (SOW) of the RFP No.8-1-3-TA-50030 dated 11/2/93. The time period of performance of this contract will be from 3/1/94 through to the end of fiscal 1999. In addition to providing the framework for the integration of the cost, schedule, and manpower planning necessary to accomplish this work it establishes the association among the WBS elements, the SOW, and the Technical Proposal.

A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program.

PubMed

Novakovic, Daniel; Cheng, Alan T L; Zurynski, Yvonne; Booy, Robert; Walker, Paul J; Berkowitz, Robert; Harrison, Henley; Black, Robert; Perry, Christopher; Vijayasekaran, Shyan; Wabnitz, David; Burns, Hannah; Tabrizi, Sepehr N; Garland, Suzanne M; Elliott, Elizabeth; Brotherton, Julia M L

2018-01-04

Recurrent respiratory papillomatosis is a rare but morbid disease caused by human papillomavirus (HPV) types 6 and 11. Infection is preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccination program (females 12-26 years in 2007-2009) in Australia, we established a method to monitor incidence and demographics of juvenile-onset recurrent respiratory papillomatosis (JORRP) cases. The Australian Paediatric Surveillance Unit undertakes surveillance of rare pediatric diseases by contacting practitioners monthly. We enrolled pediatric otorhinolaryngologists and offered HPV typing. We report findings for 5 years to end 2016. The average annual incidence rate was 0.07 per 100000. The largest number of cases was reported in the first year, with decreasing annual frequency thereafter. Rates declined from 0.16 per 100000 in 2012 to 0.02 per 100000 in 2016 (P = .034). Among the 15 incident cases (60% male), no mothers were vaccinated prepregnancy, 20% had maternal history of genital warts, and 60% were first born; 13/15 were born vaginally. Genotyped cases were HPV-6 (n = 4) or HPV-11 (n = 3). To our knowledge, this is the first report internationally documenting decline in JORRP incidence in children following a quadrivalent HPV vaccination program. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

The LIC Planners’s Guide (LPG)

DTIC Science & Technology

1992-03-01

administrative and contract law . 2. ASSIST IN CRIMINAL LAW: Assist Host Nation/Allied governments in filing and processing cases for redress of property and...forces to assist in administrative/ contract law , assist in criminal law, assist in claims, provide legal assistance, and to provide assistance in...SERVICES (LFA): 11-8 ASSIST IN ADMINISTRATIVE/ CONTRACT LAW : 11-8 ASSIST IN CLAIMS: 11-8 ASSIST IN CRIMINAL LAW: 11-8 PROVIDE INTERNATIONAL LAW

Chemical Compatibility of High-Tc Superconductors with Other Materials

DTIC Science & Technology

1988-07-22

OFFICE OF NAVAL RESEARCH oil fit Research Contract N00014-87-K-0014 R&T Code 413E26---01 0 Technical Report No. 12 0)" CHEMICAL COMPATIBILITY OF...Center University of California, Los Angeles, CA 90024-1569 In Press ’, in Z- "Physical Chemistry of High -Temperature Superc ,nductorx" D.L. Nelson and...1 flTERTALS4 12 PERSONAL AUTHOR(S .. (ilasai~ 113a TYPE Of REPORT I13b TIME COVERED 14 DATE OF REPORT (Year,PMonth, Day) S PAGE COUNT _Tehia Prpit__AI

Examples of Rate-Theory Constitutive Equations Which Unify Elasticity and Plasticity

DTIC Science & Technology

1979-01-01

8217%LEYEI IAD- E Y.30Ol CONTRACT REPORT ARBRL-CR-00389 0"I o EXAMPLES OF RATE-THEORY CONSTITUTIVE p. EQUATIONS WHICH UNIFY ELASTICITY AND PLASTICITY...of Coomerce , Springfield, Virginia 22161. ° 1I The findings in this report are not to be coustrued as an official Department of the Army position...unless so designated by other authorized docunents. ’rows )J wJ e -Aumiei or xiiiif~atwui.. ’ , j~w i th~v rwport do.Jd wro Ln’matitute i ndorvemwvstI of

Hardware test program for evaluation of baseline range/range rate sensor concept

NASA Technical Reports Server (NTRS)

1985-01-01

The Hardware Test Program for evaluation of the baseline range/range rate sensor concept was initiated 11 September 1984. This ninth report covers the period 12 May through 11 June 1885. A contract amendment adding a second phase has extended the Hardware Test Program through 10 December 1985. The objective of the added program phase is to establish range and range measurement accuracy and radar signature characteristics for a typical spacecraft target. Phase I of the Hardware Test Program was designed to reduce the risks associated with the Range/Range Rate (R/R) Sensor baseline design approach. These risks are associated with achieving the sensor performance required for the two modes of operation, the Interrupted CW (ICW) mode for initial acquisition and tracking to close-in ranges, and the CW mode, providing coverage during the final docking maneuver. The risks associated with these modes of operation have to do with the realization of adequate sensitivity to operate to their individual maximum ranges.

Biomarkers of Risk for Post-traumatic Stress Disorder (PTSD)

DTIC Science & Technology

2009-05-01

Post - traumatic Stress Disorder ( PTSD ) PRINCIPAL INVESTIGATOR: Audrey R. Tyrka, MD, PhD... Post - traumatic Stress Disorder ( PTSD ) 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-07-1-0269 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...1,087,938. 11. United States Department of Defense, “Biomarkers of risk for post - traumatic stress disorder ( PTSD ),” Principal Investigator,

Viral Oncolytic Therapeutics for Neoplastic Meningitis

DTIC Science & Technology

2013-07-01

SUBTITLE 5a. CONTRACT NUMBER Viral Oncolytic Therapeutics for Neoplastic Meningitis 5b. GRANT NUMBER W81XWH-11-1-0388 5c. PROGRAM ELEMENT NUMBER... viral and cellular kinetics with bioluminescence and PET are being written up for publication. 15. SUBJECT TERMS Neoplastic meningitis , mouse...model of meningeal metastases, breast cancer, bioluminescence, MRI, viral oncolysis, HSV- 1. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF

Increasing Opportunities for Small and Local Businesses at the Naval Postgraduate School Through Simplified Acquisitions Contracting

DTIC Science & Technology

2013-06-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA JOINT APPLIED PROJECT INCREASING OPPORTUNITIES FOR SMALL AND LOCAL BUSINESSES AT...AND SUBTITLE INCREASING OPPORTUNITIES FOR SMALL AND LOCAL BUSINESSES AT THE NAVAL POSTGRADUATE SCHOOL THROUGH SIMPLIFIED ACQUISITIONS...NAVY SMALL BUSINESS PROGRAMS, Washington Navy Yard, DC 10. SPONSORING/MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed

Environmental Science and Research Foundation. Annual technical report, April 11, 1994--December 31, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reynolds, T.D.; Morris, R.C.; Markham, O.D.

1995-06-01

This Annual Technical Report describes work conducted for the Department of Energy, Idaho Operations Office, by the Environmental Science and Research Foundation (Foundation) for work under contract DE-AC07-94ID13268. The Foundation began, on April 11, 1994, to conduct environmental surveillance near to and distant from the Idaho National Engineering Laboratory, provide environmental public relations and education related to INEL natural resource issues, and conduct ecological and radioecological research benefiting major DOE-ID programs including Waste Management, Environmental Restoration, Spent Nuclear Fuels, and Infrastructure.

The Crucial Role of the Operational Artist: A Case Study of Operation Barbarossa

DTIC Science & Technology

2017-05-25

historical case study helps to develop a better understanding of operational art today. Future studies might focus on the limitations and opportunities...The Crucial Role of the Operational Artist: A Case Study of Operation Barbarossa A Monograph by LTC (GS) Hagen H. Ruppelt German Army...a Case Study of Operation Barbarossa 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) LTC (GS) Hagen H

48 CFR 52.216-11 - Cost Contract-No Fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Cost Contract-No Fee. 52....216-11 Cost Contract—No Fee. As prescribed in 16.307(e), insert the following clause in solicitations and contracts when a cost-reimbursement contract is contemplated that provides no fee and is not a...

48 CFR 970.5227-11 - Patent rights-management and operating contracts, for-profit contractor, non-technology transfer.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and operating contracts, for-profit contractor, non-technology transfer. 970.5227-11 Section 970.5227...-technology transfer. Insert the following clause in solicitations and contracts in accordance with 970.2703-1(b)(4): Patent Rights—Management and Operating Contracts, for-Profit Contractor, Non-Technology...

Trainability of Muscular Activity Level during Maximal Voluntary Co-Contraction: Comparison between Bodybuilders and Nonathletes

PubMed Central

Maeo, Sumiaki; Takahashi, Takumi; Takai, Yohei; Kanehisa, Hiroaki

2013-01-01

Antagonistic muscle pairs cannot be fully activated simultaneously, even with maximal effort, under conditions of voluntary co-contraction, and their muscular activity levels are always below those during agonist contraction with maximal voluntary effort (MVE). Whether the muscular activity level during the task has trainability remains unclear. The present study examined this issue by comparing the muscular activity level during maximal voluntary co-contraction for highly experienced bodybuilders, who frequently perform voluntary co-contraction in their training programs, with that for untrained individuals (nonathletes). The electromyograms (EMGs) of biceps brachii and triceps brachii muscles during maximal voluntary co-contraction of elbow flexors and extensors were recorded in 11 male bodybuilders and 10 nonathletes, and normalized to the values obtained during the MVE of agonist contraction for each of the corresponding muscles (% EMGMVE). The involuntary coactivation level in antagonist muscle during the MVE of agonist contraction was also calculated. In both muscles, % EMGMVE values during the co-contraction task for bodybuilders were significantly higher (P<0.01) than those for nonathletes (biceps brachii: 66±14% in bodybuilders vs. 46±13% in nonathletes, triceps brachii: 74±16% vs. 57±9%). There was a significant positive correlation between a length of bodybuilding experience and muscular activity level during the co-contraction task (r = 0.653, P = 0.03). Involuntary antagonist coactivation level during MVE of agonist contraction was not different between the two groups. The current result indicates that long-term participation in voluntary co-contraction training progressively enhances muscular activity during maximal voluntary co-contraction. PMID:24260233

Naming in a Programming Support Environment.

DTIC Science & Technology

1984-02-01

and Control, 1974. 10. T. E. Cheatham. An Overview of the Harvard Program Development System. I; Software Engineering Environments, H. Hunke, Ed.. North...Holland Publishing Compary, 1981, pp. 253-266. 11. T. E. Cheatham. Comparing Programming Support Environments. In Software Engineering Environments...Company. 1981. Third Edition 16. F. DeRemer and H Kron Programming -inthe Large Versus Programming -in-theSmall. IEEE Transactions on Software Engineering

48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Restoration Program construction contracts. 228.102-70 Section 228.102-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction contracts...

Acute physical exercise is safe in patients with primary antiphospholipid syndrome with exclusive venous thrombosis and under oral anticoagulation with warfarin.

PubMed

Garcia, Carolina Borges; Seguro, Luciana Parente Costa; Perandini, Luiz Augusto; de Sá Pinto, Ana Lúcia; Lima, Fernanda Rodrigues; Negrão, Carlos Eduardo; Bonfa, Eloisa; Borba, Eduardo Ferreira

2014-12-01

The purpose of present study was to evaluate the effects of maximal acute physical exercise on prothrombin time/international normalized ratio (PT/INR) in patients with primary antiphospholipid syndrome (PAPS) under oral anticoagulation with warfarin and the safety of acute exercise in regard to thrombosis and bleeding risk. Eighteen physically inactive women with PAPS (Sydney criteria) with exclusive venous events and without thrombocytopenia were included. All patients were under stable warfarin therapy (PT/INR target: 2.0-3.0). Eighteen age-matched healthy sedentary women without thrombosis/bleeding disorders were selected as controls. All subjects performed a maximal exercise test, and capillary blood samples were obtained pre-, post- and at 1-h post-exercise (recovery time) for PT/INR analysis using a portable CoaguCheck. PAPS patients and controls had similar mean age (31.50 ± 8.06 vs. 29.61 ± 7.05 years, p = 0.46) and body mass index (24.16 ± 3.67 vs. 24.66 ± 2.71 kg/m(2), p = 0.65). PAPS had a mild but significant increase in PT/INR value at 1-h post-exercise (recovery) compared with pre- (2.33 ± 0.34 vs. 2.26 ± 0.29, p = 0.001) and post-exercise (2.33 ± 0.34 vs. 2.26 ± 0.32, p = 0.001) that was observed in 61.11 % of these patients. None of the subjects had thrombotic or bleeding complications related to the acute exercise. Acute exercise in patients with PAPS with exclusive venous thrombosis was safe with a minor increase in PT/INR. This is an important step to introduce regular exercise training as a therapeutic tool in the management of these patients.

Detection of Neutral Phosphorus in the Near-ultraviolet Spectra of Late-type Stars

NASA Astrophysics Data System (ADS)

Roederer, Ian U.; Jacobson, Heather R.; Thanathibodee, Thanawuth; Frebel, Anna; Toller, Elizabeth

2014-12-01

We report the detection of several absorption lines of neutral phosphorus (P, Z = 15) in archival near-ultraviolet spectra obtained with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. We derive phosphorus abundances or interesting upper limits in 14 late-type stars with metallicities spanning -3.8 < [Fe/H] <-0.1. Previously, phosphorus had only been studied in Galactic stars with -1.0 < [Fe/H] <+0.3. Iron lines reveal abundance offsets between the optical and ultraviolet regions, and we discuss and apply a correction factor to account for this offset. In stars with [Fe/H] >-1.0, the [P/Fe] ratio decreases toward the solar value with increasing metallicity, in agreement with previous observational studies. In stars with [Fe/H] <-1.0, lang[P/Fe]rang = +0.04 ± 0.10, which overlaps with the [P/Fe] ratios found in several high-redshift damped Lyman-α systems. This behavior hints at a primary origin in massive stars. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. This work is supported through program AR-13246 and is based on observations associated with programs GO-7348, GO-7433, GO-8197, GO-9048, GO-9049, GO-9455, GO-9804, GO-12268, GO-12554, and GO-12976. Portions of this work are based on data obtained from the European Southern Observatory (ESO) Science Archive Facility. These data are associated with Programs 065.L-0507(A), 067.D-0439(A), 072.B-0179(A), 074.C-0364(A), 076.B-0055(A), and 266.D-5655(A). Portions of this research have also made use of the Keck Observatory Archive (KOA), which is operated by the W.M. Keck Observatory and the NASA Exoplanet Science Institute (NExScI), under contract with the National Aeronautics and Space Administration. These data are associated with Programs H2aH (P.I: Boesgaard), H5aH (P.I: Stephens), and H47aH (P.I: Boesgaard). Other portions of this work are based on data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile, and the McDonald Observatory of The University of Texas at Austin.

77 FR 2653 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212 and 252 RIN 0750-AH27 Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military-Purpose Nondevelopmental Items (DFARS Case 2011-D034) AGENCY: Defense Acquisition Regulations System...

Protective Role of Acidic pH-Activated Chloride Channel in Severe Acidosis-Induced Contraction from the Aorta of Spontaneously Hypertensive Rats

PubMed Central

Ma, Zhiyong; Qi, Jia; Fu, Zhijie; Ling, Mingying; Li, Li; Zhang, Yun

2013-01-01

Severe acidic pH-activated chloride channel (ICl,acid) has been found in various mammalian cells. In the present study, we investigate whether this channel participates in reactions of the thoracic aorta to severe acidosis and whether it plays a role in hypertension. We measured isometric contraction in thoracic aorta rings from spontaneously hypertensive rats (SHRs) and normotensive Wistar rats. Severe acidosis induced contractions of both endothelium-intact and -denuded thoracic aorta rings. In Wistar rats, contractions did not differ at pH 6.4, 5.4 and 4.4. However, in SHRs, contractions were higher at pH 5.4 or 4.4 than pH 6.4, with no difference between contractions at pH 5.4 and 4.4. Nifedipine, ICl,acid blockers 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and 4,4′-diisothiocyanatostilbene-2, 2′-disulfonic acid (DIDS) inhibited severe acidosis-induced contraction of aortas at different pH levels. When blocking ICl,acid, the remnant contraction was greater at pH 4.4 than pH 5.4 and 6.4 for both SHRs and Wistar rats. With nifedipine, the remnant contraction was greatly reduced at pH 4.4 as compared with at pH 6.4 and 5.4. With NPPB or DIDS, the ratio of remnant contractions at pH 4.4 and 5.4 (R4.4/5.4) was lower for SHRs than Wistar rats (all <1). However, with nifedipine, the R4.4/5.4 was higher for SHRs than Wistar rats (both >1). Furthermore, patch clamp recordings of ICl,acid and intracellular Ca2+ measurements in smooth muscle cells confirmed these findings. ICl,acid may protect arteries against excess vasoconstriction under extremely acidic extracellular conditions. This protective effect may be decreased in hypertension. PMID:23580361

48 CFR 19.708 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a) Insert the clause at 52.219-8, Utilization of Small Business Concerns, in solicitations and contracts... clause at 52.219-9, Small Business Subcontracting Plan, in solicitations and contracts that offer...

48 CFR 19.708 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a) Insert the clause at 52.219-8, Utilization of Small Business Concerns, in solicitations and contracts... clause at 52.219-9, Small Business Subcontracting Plan, in solicitations and contracts that offer...

48 CFR 19.708 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a) Insert the clause at 52.219-8, Utilization of Small Business Concerns, in solicitations and contracts... clause at 52.219-9, Small Business Subcontracting Plan, in solicitations and contracts that offer...

48 CFR 19.708 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 19.708 Contract clauses. (a) Insert the clause at 52.219-8, Utilization of Small Business Concerns, in solicitations and contracts... clause at 52.219-9, Small Business Subcontracting Plan, in solicitations and contracts that offer...

48 CFR 519.7017 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7017 Contract clauses. (a) The contracting officer shall insert the clause at 552.219-75, GSA Mentor-Protégé Program, in all unrestricted... small business protégé. (b) The contracting officer shall insert the clause at 552.219-76, Mentor...

Effects of space flight on the immunohistochemical demonstration of connexin 26 and connexin 43 in the postpartum uterus of rats

NASA Technical Reports Server (NTRS)

Burden, H. W.; Zary, J.; Alberts, J. R.

1999-01-01

The effect of space flight in a National Aeronautics and Space Administration shuttle was studied in pregnant rats. Rats were launched on day 11 of gestation and recovered on day 20 of gestation. Pregnancy was allowed to proceed to term and rats delivered vaginally on days 22-23, although flight animals required more labour contractions to complete the delivery process. Pups were placed with foster dams and connexin 26 and 43 were examined in the uterus of flight animals approximately 3 h after delivery. Space flight did not affect uterine connexin 26, localized primarily in epithelial cells of the endometrium, but decreased connexin 43, the major gap junction protein in the myometrium. It is suggested that decreased connexin 43 alters synchronization and coordination of labour contractions, resulting in a requirement for more contractions to complete the delivery process.

Bright light and thermoregulatory responses to exercise.

PubMed

Atkinson, G; Barr, D; Chester, N; Drust, B; Gregson, W; Reilly, T; Waterhouse, J

2008-03-01

The thermoregulatory responses to morning exercise after exposure to different schedules of bright light were examined. At 07:00 h, six males ran on two occasions in an environmental chamber (temperature = 31.4 +/- 1.0 degrees C, humidity = 66 +/- 6 %) for 40 min at 60 % of maximal oxygen uptake. Participants were exposed to bright light (10,000 lux) either between 22:00 - 23:00 h (BT (low)) or 06:00 - 07:00 h (BT (high)). Otherwise, participants remained in dim light (< 50 lux). It was hypothesized that BT (low) attenuates core temperature during morning exercise via the phase-delaying properties of evening bright light and by avoiding bright light in the morning. Evening bright light in BT (low) suppressed (p = 0.037) the increase in melatonin compared to dim light (1.1 +/- 11.4 vs. 15.2 +/- 19.7 pg x ml (-1)) and delayed (p = 0.034) the core temperature minimum by 1.46 +/- 1.24 h. Core temperature was 0.20 +/- 0.17 degrees C lower in BT (low) compared to BT (high) during the hour before exercise (p = 0.036), with evidence (p = 0.075) that this difference was maintained during exercise. Conversely, mean skin temperature was 1.0 +/- 1.7 degrees C higher during the first 10 min of exercise in BT (low) than in BT (high) (p = 0.030). There was evidence that the increase in perceived exertion was attenuated in BT (low) (p = 0.056). A chronobiologically-based light schedule can lower core temperature before and during morning exercise in hot conditions.

26 CFR 1.817-5 - Diversification requirements for variable annuity, endowment, and life insurance contracts.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) and (h). Likewise, if a variable contract is not treated as an annuity contract under section 72, the... endowment contract under section 7702 (g) and (h). (2) Inadvertent failure to diversify. The investments of... considered adequately diversified for purposes of this section and section 817(h) only if— (A) No more than...

Evaluate fundamental approaches to longwall dust control. Phase III report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babbitt, C.; Bartlett, P.; Kelly, J.

1984-03-31

The overall objective of the contract is to evaluate the effectiveness of available dust control technology for double-drum shearer longwall sections in a coordinated, systematic program at a few longwall test sections and to make the results available to the entire coal mining industry. This program is investigating nine different dust control techniques. These nine subprograms encompass a broad range of dust control measures ranging from administrative controls to new hardware. They span not only presently employed methods but also those recently adopted in the United States and those proposed for the future. This report documents the Phase III effortmore » on each of the subprograms. For clarity, the report is divided in sections by subprogram as follows: Section 2, Subprogram A - passive barriers/spray air movers for dust control; Section 3, Subprogram B - practical aspects of deep cutting; Section 4, Subprogram C - stage loader dust control; Section 5, Subprogram D - longwall automation technology; Section 6, Subprogram E - longwall application of ventilation curtains; Section 7, Subprogram F - reversed drum rotation; Section 8, Subprogram G - reduction of shield generated dust; Section 9, Subprogram H - air canopies for longwalls; and Section 10, Subprogram I - mining practices. 43 figures, 11 tables.« less

The Effect of Optional Summer Transition to High School Program Participation and Required School Year Long Placement on a Core Content Team on Ninth-Grade Students At-Risk Measured Achievement, Engagement, and Behavior Outcomes

ERIC Educational Resources Information Center

Pokorski, Frances K.

2011-01-01

No significant difference in beginning ninth-grade pretest compared to ending ninth-grade posttest comparisons of American History t(17) = 0.34, p = 0.37 (one-tailed), d = 0.09, English t(17) = 1.40, p = 0.09 (one-tailed), d = 0.34, and Biology (t(17) = -1.58, p = 0.07 (one-tailed), d = -0.22, course grade scores were observed for students…

Manufacturing Methods and Technology Program for Low Cost Hybrid Silicon Photodetector Modules

DTIC Science & Technology

1979-12-30

RESEARCH LN EVEMN TECHNICAL REPORT 4 CORADOOM- 77- C -0489-F I CMANUFACTURING METHODS AND TECHNOLOGY PROGRAM FOR LOW COST HYBRID SILICON PHOTODETECTORS...rINAL REPORT OR US ARMY CONTRACT NO, DAAD07-77- C -0489 TITLED 11MM&TMud SURE FOR COS HYBRID SILICON PHOTODRTECTOR MODULS", DATED 79/12/30 Gentlemen...when it is no longer needed. Do not return it to the originator. D.-stributi-on! Availability COcas- :Dist c specia S I ’ Cb.A *"itI. -P0 ~~J~,+~1

Temporal Clustering in the Multi-Target Tracking Environment

DTIC Science & Technology

1988-08-01

UNLASS IliED % ,, SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered)_ REPORT DOCUMENTATION PAGE BF READ INSTRUCTIONS6. PEFORE COMPLETING FORM...1. REPORT NUMBER (. )OVT ACCESSION No. 3. RE-Ur-’SAFIT/CI/NR 88- 1 ? ,7 1 11 - _t tA Jr TITLE (and Subtitle) S. TYPE OF REPORT A PERIOD COVEREDTLMfP6...AL C405TEW .GI )K T 4 MULT)- F11M9THESI I, TiNtLqET TOLFNCK lUG 6.mVjllop,3MrJT TEI ~6. PERFORMING O-4O. REPORT hUMBER AU THOR(s) 8. CONTRACT OR

Optically Pumped Coherent Mechanical Oscillators: The Laser Rate Equation Theory and Experimental Verification

DTIC Science & Technology

2012-10-23

Naeini A H, Hill J T, Krause A, Groblacher S, Aspelmeyer M and Painter O 2011 Nature 478 89 [14] Siegman A E 1986 Lasers (Sausalito, CA: University... laser rate equation theory and experimental verification 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...coherent mechanical oscillators: the laser rate equation theory and experimental verification J B Khurgin1, M W Pruessner2,3, T H Stievater2 and W S

Characterization of Nonlinear Systems with Memory by Means of Volterra Expansions with Frequency Partitioning: Application to a Cicada Mating Call

DTIC Science & Technology

2010-06-15

Partitioning Application to a Cicada Mating Call Albert H. Nuttall Adaptive Methods Inc. Derke R. Hughes NUWC Division Newport IVAVSEA WARFARE...Frequency Partitioning: Application to a Cicada Mating Call 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Albert H... cicada mating call with a distinctly non-white and non-Gaussian excitation gives good results for the estimated first- and second-order kernels and

Differential Splicing of Oncogenes and Tumor Suppressor Genes in African- and Caucasian-American Populations: Contributing Factor in Prostate Cancer Disparities

DTIC Science & Technology

2015-10-01

Populations: Contributing Factor in Prostate Cancer Disparities? PRINCIPAL INVESTIGATOR: Norman H Lee, Ph.D. CONTRACTING ORGANIZATION: George Washington...Prostate Cancer Disparities? 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Norman H Lee, PhD; Bi-Dar Wang, PhD; Jacqueline Olender (PhD graduate...suppressor genes in prostate cancer disparities between African American (AA) and Caucasian American (CA) prostate cancer (PCa). In year 1 of this award

76 FR 34711 - Notice of Hearing; Reconsideration of Disapproval of Colorado State Plan Amendments (SPA) 10-034

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... transportation services, and Indian Health Programs and Urban Indian Organizations that are transportation... Indian beneficiaries who receive transportation services, and Indian Health Programs and Urban Indian... non-emergency medical transportation. The disapproval was based on a finding that the State had not...

Program Oversight of Contractors on the Battlefield

DTIC Science & Technology

2011-03-23

contractor to another. For example, under Blackwater Security Firm‟s contract for private security services in Iraq, the contract paid workers guarding...subcontracting relationship with Blackwater . 38 The Coalition Provisional Authority (CPA) provided less than adequate control for approximately $8.8...the Army‟s LOGCAP, the Navy ‟s Construction Capabilities Contract Program, and the Air Force‟s Contract Augmentation Program. These programs remain

PECASE: All-Optical Photonic Integrated Circuits in Silicon

DTIC Science & Technology

2011-01-14

COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION...REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11

Combat Stress and Substance Abuse Intervention

DTIC Science & Technology

2015-10-01

SUBTITLE Combat Stress and Substance Abuse Intervention 5a. CONTRACT NUMBER W81XWH-11-2-0197 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...SUBJECT TERMS Combat stress, substance abuse , alcohol, brief intervention, military personnel 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...reduce stress reactions and substance abuse . These data are vital to understanding additional steps the military might take in addressing issues of

Ten-College Conference on Implications of the Bureau of Research Teacher Education Project for Developing Institutions (July 11-12, 1969).

ERIC Educational Resources Information Center

1969

This document reports an initial conference of ten small developing colleges which are contracted to study the feasibility of instituting all or parts of the nine teacher education program models developed in the Teacher Education Project of the U.S. Office of Education (USOE). Included in the report are summaries of prepared statements by each…

Heat and Molecules. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 10.

ERIC Educational Resources Information Center

Brophy, M.; Fryars, M.

Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P8 SIS unit deals with: (1) changes in temperature which make matter expand and contract (and how this affects…

A Charge-Coupled Device (CCD) Memory for Navy C3 Systems

DTIC Science & Technology

1976-07-30

CONTRACT OR GRANT mumUER(a) __ _ _ IT /Ii,/skiA ~ f I. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Naval...kcy A1is al)oed inl soice ronCilites to allow tilc user to rely pie th Lilst cha~r.,.oer. Ini I1)11 M( )lDl-, a user is, allowed to cdit the data oin

The Interplay Between Estrogen and Replication Origins in Breast Cancer DNA Amplification

DTIC Science & Technology

2013-09-01

Replication Origins in Breast Cancer DNA Amplification PRINCIPAL INVESTIGATOR: Cinzia Casella CONTRACTING ORGANIZATION: Brown...Interplay Between Estrogen and Replication Origins in Breast Cancer DNA Amplification 5b. GRANT NUMBER W81XWH-11-1-0599 5c. PROGRAM ELEMENT NUMBER 6... amplification and oncogenes activation in breast cancer cells? This project aims to understand the role of estrogen in inducing re-replication, thus

Effectiveness of adding voluntary pelvic floor muscle contraction to a Pilates exercise program: an assessor-masked randomized controlled trial.

PubMed

Torelli, Luiza; de Jarmy Di Bella, Zsuzsanna Ilona Katalin; Rodrigues, Claudinei Alves; Stüpp, Liliana; Girão, Manoel João Batista Castello; Sartori, Marair Gracio Ferreira

2016-11-01

The purpose of this study was to evaluate the effectiveness of adding voluntary pelvic floor muscle contraction (PFMC) to a Pilates exercise program in sedentary nulliparous women. Fifty-seven healthy nulliparous and physically inactive women were randomized to a Pilates exercise program (PEP) with or without PFMC. Forty-eight women concluded this study (24 participants for each group). Each woman was evaluated before and after the PEP, by a physiotherapist and an urogynecologist (UG). Neither of the professionals was revealed to them. This physiotherapist measured their pelvic floor muscle strength by using both a perineometer (Peritron) and vaginal palpation (Oxford Scale). The UG, who performed 3D perineal ultrasound examinations, collected their data and evaluated the results for pubovisceral muscle thickness and the levator hiatus area (LA). Both professionals were blinded to the group allocation. The protocol for both groups consisted of 24 bi-weekly 1-h individual sessions of Pilates exercises, developed by another physiotherapist who specializes in PFM rehabilitation and the Pilates technique. The PEP+ PFMC group showed significantly greater strength improvements than the PEP group when comparing the Oxford scale, vaginal pressure and pubovisceral muscle thickness during contraction measurements at baseline and post-treatment. Our findings suggest that adding a voluntary PFMC to a Pilates exercise program is more effective than Pilates alone in improving PFM strength in sedentary nulliparous women.

48 CFR 1602.170-11 - Negotiated benefits contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL DEFINITIONS OF WORDS AND TERMS Definitions of FEHBP Terms 1602.170-11 Negotiated benefits contracts. Negotiated benefits contracts are FEHBP... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Negotiated benefits...

Electronic spreadsheet vs. manual payroll.

PubMed

Kiley, M M

1991-01-01

Medical groups with direct employees must employ someone or contract with a company to compute payroll, writes Michael Kiley, Ph.D., M.P.H. However, many medical groups, including small ones, own a personal or minicomputer to handle accounts receivable. Kiley explains, in detail, how this same computer and a spreadsheet program also can be used to perform payroll functions.

Technical Leadership Development Program

DTIC Science & Technology

2010-12-13

the traditional tenets of leadership and management , systems thinking, understanding SOS issues, and thinking and acting holistically. Our research...international element 2.0 Enterprise Leadership and Management UNCLASSIFIED Contract Number: H98230-08-D-0171 DO 002. TO002, RT 004 Report No...mechanisms for leadership of the overall technical effort, for systems engineering, for requirements, management , and for systems integration. o Develop

Response of timber growth and avian communities to quality vegetation management in mid-rotation crp pine plantations

Treesearch

Brandon G. Sladek; Ian A. Munn; L. Wes Burder; Scott D. Roberts

2006-01-01

Provisions of the 2002 Farm Bill gave Conservation Reserve Program (CRP) participants greater flexibility to implement mid-contract management activities that encourage wildlife habitat improvement and timber production. Quality Vegetation Management (QVM) is one such technique that utilizes the selective herbicide Imazapyr and prescribed burning. Timber growth (d.b.h...

Supplemental Grounding of Extended EMP Collectors.

DTIC Science & Technology

1982-01-31

G52AAXEX40602 H2590D as Contract DNA 001-80-C-0294. The program was monitored by Major Blair Williams, RAEE . The work described in this report was...ATTN: RAEE ATTN: DPOPM-COM-W-D ATTN RAAE ATTN: NATA Deputy Chief of Staff for Rsch Dev & Acq 4 cy ATTN: TITL ATTN: DAMA-CSS-N Defense Tech Info Ctr

Millennials: Rendezvous with Destiny?

DTIC Science & Technology

2008-03-05

St ra te gy R es ea rc h Pr oj ec t MILLENNIALS : RENDEZVOUS WITH DESTINY? BY COLONEL FREDERICK L. FAHLBUSCH United States Air Force...AND SUBTITLE Millennials Rendezvou with Destiny? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Frederick...PROJECT MILLENNIALS : RENDEZVOUS WITH DESTINY? by Colonel Frederick L. Fahlbusch United States Air Force

Cerebrovascular Injury in Blast Loading

DTIC Science & Technology

2010-01-01

TITLE: Cerebrovascular injury in blast loading PRINCIPAL INVESTIGATOR: Kenneth L. Monson, PhD...SUBTITLE Cerebrovascular injury in blast loading 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-08-1-0295 5c. PROGRAM ELEMENT NUMBER 6...and pH control. 15. SUBJECT TERMS Blast brain injury; cerebrovascular injury and dysfunction; shock tube 16. SECURITY CLASSIFICATION OF: 17

Scanning the skeleton of the 4D F-theory landscape

NASA Astrophysics Data System (ADS)

Taylor, Washington; Wang, Yi-Nan

2018-01-01

Using a one-way Monte Carlo algorithm from several different starting points, we get an approximation to the distribution of toric threefold bases that can be used in four-dimensional F-theory compactification. We separate the threefold bases into "resolvable" ones where the Weierstrass polynomials ( f, g) can vanish to order (4 , 6) or higher on codimension-two loci and the "good" bases where these (4 , 6) loci are not allowed. A simple estimate suggests that the number of distinct resolvable base geometries exceeds 103000, with over 10250 "good" bases, though the actual numbers are likely much larger. We find that the good bases are concentrated at specific "end points" with special isolated values of h 1,1 that are bigger than 1,000. These end point bases give Calabi-Yau fourfolds with specific Hodge numbers mirror to elliptic fibrations over simple threefolds. The non-Higgsable gauge groups on the end point bases are almost entirely made of products of E 8, F 4, G 2 and SU(2). Nonetheless, we find a large class of good bases with a single non-Higgsable SU(3). Moreover, by randomly contracting the end point bases, we find many resolvable bases with h 1,1( B) ˜ 50-200 that cannot be contracted to another smooth threefold base.

Effects of the FITKids randomized controlled trial on executive control and brain function.

PubMed

Hillman, Charles H; Pontifex, Matthew B; Castelli, Darla M; Khan, Naiman A; Raine, Lauren B; Scudder, Mark R; Drollette, Eric S; Moore, Robert D; Wu, Chien-Ting; Kamijo, Keita

2014-10-01

To assess the effect of a physical activity (PA) intervention on brain and behavioral indices of executive control in preadolescent children. Two hundred twenty-one children (7-9 years) were randomly assigned to a 9-month afterschool PA program or a wait-list control. In addition to changes in fitness (maximal oxygen consumption), electrical activity in the brain (P3-ERP) and behavioral measures (accuracy, reaction time) of executive control were collected by using tasks that modulated attentional inhibition and cognitive flexibility. Fitness improved more among intervention participants from pretest to posttest compared with the wait-list control (1.3 mL/kg per minute, 95% confidence interval [CI]: 0.3 to 2.4; d = 0.34 for group difference in pre-to-post change score). Intervention participants exhibited greater improvements from pretest to posttest in inhibition (3.2%, 95% CI: 0.0 to 6.5; d = 0.27) and cognitive flexibility (4.8%, 95% CI: 1.1 to 8.4; d = 0.35 for group difference in pre-to-post change score) compared with control. Only the intervention group increased attentional resources from pretest to posttest during tasks requiring increased inhibition (1.4 µV, 95% CI: 0.3 to 2.6; d = 0.34) and cognitive flexibility (1.5 µV, 95% CI: 0.6 to 2.5; d = 0.43). Finally, improvements in brain function on the inhibition task (r = 0.22) and performance on the flexibility task correlated with intervention attendance (r = 0.24). The intervention enhanced cognitive performance and brain function during tasks requiring greater executive control. These findings demonstrate a causal effect of a PA program on executive control, and provide support for PA for improving childhood cognition and brain health. Copyright © 2014 by the American Academy of Pediatrics.

7 CFR 760.818 - Marketing contracts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing contracts. (a) A marketing contract must meet all of the conditions outlined in paragraphs (b), (c), and (d...

7 CFR 760.818 - Marketing contracts.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 7 2013-01-01 2013-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing contracts. (a) A marketing contract must meet all of the conditions outlined in paragraphs (b), (c), and (d...

7 CFR 760.818 - Marketing contracts.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 7 2012-01-01 2012-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing contracts. (a) A marketing contract must meet all of the conditions outlined in paragraphs (b), (c), and (d...

7 CFR 760.818 - Marketing contracts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 7 2014-01-01 2014-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing contracts. (a) A marketing contract must meet all of the conditions outlined in paragraphs (b), (c), and (d...

7 CFR 760.818 - Marketing contracts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing contracts. (a) A marketing contract must meet all of the conditions outlined in paragraphs (b), (c), and (d...

48 CFR 952.211-71 - Priorities and allocations for energy programs (contracts).

Code of Federal Regulations, 2010 CFR

2010-10-01

... for energy programs (contracts). 952.211-71 Section 952.211-71 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.211-71 Priorities and allocations for energy programs (contracts). As prescribed in 911.604(b...

48 CFR 952.211-71 - Priorities and allocations for energy programs (contracts).

Code of Federal Regulations, 2013 CFR

2013-10-01

... for energy programs (contracts). 952.211-71 Section 952.211-71 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.211-71 Priorities and allocations for energy programs (contracts). As prescribed in 911.604(b...

48 CFR 952.211-71 - Priorities and allocations for energy programs (contracts).

Code of Federal Regulations, 2012 CFR

2012-10-01

... for energy programs (contracts). 952.211-71 Section 952.211-71 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.211-71 Priorities and allocations for energy programs (contracts). As prescribed in 911.604(b...

48 CFR 952.211-71 - Priorities and allocations for energy programs (contracts).

Code of Federal Regulations, 2011 CFR

2011-10-01

... for energy programs (contracts). 952.211-71 Section 952.211-71 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.211-71 Priorities and allocations for energy programs (contracts). As prescribed in 911.604(b...

45 CFR 98.11 - Administration under contracts and agreements.

Code of Federal Regulations, 2012 CFR

2012-10-01

....11 Section 98.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND General Application Procedures § 98.11 Administration under contracts and... priorities for the expenditure of CCDF funds; (2) Promulgate all rules and regulations governing overall...

45 CFR 98.11 - Administration under contracts and agreements.

Code of Federal Regulations, 2013 CFR

2013-10-01

....11 Section 98.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND General Application Procedures § 98.11 Administration under contracts and... priorities for the expenditure of CCDF funds; (2) Promulgate all rules and regulations governing overall...

48 CFR 622.404-11 - Wage determination appeals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Wage determination appeals. 622.404-11 Section 622.404-11 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC... Construction 622.404-11 Wage determination appeals. The cognizant contracting activity is the contracting...

The impact of nutrient density, feed form, and photoperiod on the walking ability and skeletal quality of broiler chickens.

PubMed

Brickett, K E; Dahiya, J P; Classen, H L; Annett, C B; Gomis, S

2007-10-01

The aim of this study was to examine the main and interaction effects of 3 dietary nutrient densities (low-, medium-, high-density), 2 feed forms (mash, pellet), and 2 lighting programs (20L:4D, 12L:12D) on the walking ability and skeletal quality of broiler chickens raised to a young age (35 d). Forty-eight birds per treatment (nutrient density x feed form x lighting program subclass) were randomly selected (0 d) for assessment of their gait score (GS) and BW at 11, 18, 25, and 32 d. Samples of birds from various GS classifications were selected at 32 d for radiographs and histology of the femur and tibiotarsus. Bone ash (BA) content was evaluated at 35 d from the right tibiotarsus to assess bone quality. Overall, the mean GS values were low (GS <1). An interaction existed between lighting and sex. Males provided with 20L:4D had a higher GS (0.74) than females (0.45), and this score was greater than for broilers provided with 12L:12D (0.34 and 0.26 for males and females, respectively). Feeding mash reduced the GS (0.29) compared with pellet rations (0.62). The GS increased with age, and by 32 d 2.43% of birds had a GS >/=3. Broilers fed mash had a higher BA content (50.6%) than birds fed pellet diets (49.8%), and the 12L:12D value (50.5%) was greater than for 20L:4D (48.9%). Last, males had a lower BA content (49.8%) than females (50.6%). A positive correlation existed between BW and GS based on sex, where BW at 11, 18, and 25 d affected bird mobility at 32 d (r(2) = 0.39, 0.49, and 0.50 for males; r(2) = 0.34, 0.37, and 0.36 for females, respectively). Radiography and histology were unaffected by GS. This study confirmed that a reduced growth rate improved GS but also demonstrated that overall bird mobility was good and the incidence of skeletal disease was low.

Pharmacy benefit management contracting: an assessment from a recent public sector procurement experience.

PubMed

Bae, Jay P; Justice, Paul G

2002-01-01

In order to contain the cost of pharmaceuticals while preserving access to medically necessary drugs, Georgia state government competitively selected a single vendor in May of 2000 to manage combined pharmacy benefits under all of the state's health programs. By initiating this procedure, it intended to maximize the state's purchasing power and improve efficiency while streamlining the administrative structure. Synthesizing information from the request for proposal (RFP) and technical proposals submitted by 11 pharmacy benefit managers (PBMs) in response, we describe a model of public sector PBM contracting approach and present an assessment of the industry's service capability and performance statistics. Payers who have been using PBM services may find it interesting to compare their experience with the recent Georgia experience. Those who are considering contracting with a PBM will find the assessment of the PBM industry timely and informative.

Absorption Kinetics of the Main Conjugated Linoleic Acid Isomers in Commercial-Rich Oil after Oral Administration in Rats.

PubMed

Rodríguez-Alcalá, Luís M; Ares, Irma; Fontecha, Javier; Martínez-Larrañaga, María-Rosa; Anadón, Arturo; Martínez, María-Aránzazu

2017-09-06

This study aimed to assess the oral absorption and plasma kinetics of two main isomers contained in commercial conjugated linoleic acid (CLA)-rich oil (Tonalin TG-80), rumenic acid (RA), and C18:2 trans-10, cis-12. The isomer plasma disposition after the single oral dose of 3000 mg of Tonalin TG-80/kg, containing 1200 mg/kg of each isomer, was studied in rats. The isomer plasma concentrations were determined by gas chromatography with flame ionization detection. The plasma kinetics showed rapid oral absorption of RA and C18:2 trans-10, cis-12 (t 1/2a 0.34 ± 0.09 and 0.53 ± 0.01 h) and slow elimination (t 1/2β 25.68 ± 3.29 and 18.12 ± 1.71 h); the maximal isomer plasma concentrations (C max ) of 8.48 ± 0.98 and 7.67 ± 0.80 μg mL -1 , respectively, were estimated at 2.08 ± 0.14 and 2.26 ± 0.11 h. Our results from a preclinical kinetic study in rats help to design future studies in humans for evaluating the CLA isomer dose-response.

Improving food choices among Supplemental Nutrition Assistance Program recipients.

PubMed

You, Wen; Mitchell, Paul D; Nayga, Rodolfo M

2012-07-01

We used a principal-agent framework to examine the feasibility of two proposed modifications to the Supplemental Nutrition Assistance Program with the goal of encouraging healthier food choices among program participants. Specifically, we analyzed two types of contract: a restricted contract and an incentive contract. The restricted contract did not allow the purchase of unhealthy foods with program benefits, but compensated participants by increasing total benefits. The incentive contract provided increased benefits that varied according to the percentage of healthy foods purchased with program benefits. The theoretical results revealed the mechanisms for the two alternative contracts, the conditions under which each would be effective, and the key empirical questions to be examined for future policy analysis. Copyright © 2011 John Wiley & Sons, Ltd.

42 CFR 455.236 - Renewal of a contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PROGRAM INTEGRITY: MEDICAID Medicaid Integrity Program § 455.236 Renewal of a contract. (a) CMS specifies the initial contract term in the Medicaid integrity audit program...

48 CFR 1815.7001 - NASA Ombudsman Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

48 CFR 1815.7001 - NASA Ombudsman Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

48 CFR 1815.7001 - NASA Ombudsman Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

48 CFR 1815.7001 - NASA Ombudsman Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

48 CFR 1815.7001 - NASA Ombudsman Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Ombudsman Program... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Ombudsman 1815.7001 NASA Ombudsman Program. NASA's implementation of an ombudsman program is in NPR 5101.33, Procurement Advocacy...

12 CFR 361.4 - What contracts are eligible for this outreach program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false What contracts are eligible for this outreach program? 361.4 Section 361.4 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY MINORITY AND WOMEN OUTREACH PROGRAM CONTRACTING § 361.4 What contracts are...

A Pilates exercise program with pelvic floor muscle contraction: Is it effective for pregnant women? A randomized controlled trial.

PubMed

Dias, Naiara T; Ferreira, Letícia R; Fernandes, Mariana G; Resende, Ana Paula M; Pereira-Baldon, Vanessa S

2018-01-01

The aim of this study was to evaluate the effectiveness of a Pilates exercise program with pelvic floor muscle (PFM) contraction compared to a conventional intervention in pregnant women. Fifty primiparous women, without gestational alterations, were randomized to the Pilates group (n = 25) and control group (n = 25). Interventions for both groups consisted of twice-weekly sessions of 1 h each during the period between the 14-16th and 32-34th gestational weeks. The Pilates group performed a Pilates exercises program with the addition of voluntary PFM contraction. Mat-based Pilates exercises were performed involving movement of the upper limbs, lower limbs and trunk in all sessions. The Control group walked for 10 min and performed strengthening exercises of the lower limbs, upper limbs, and trunk with resistance from an elastic band and body weight. Each woman was evaluated by an unblinded physiotherapist before and after intervention for primary (PFM strength using a manometer) and secondary (PFM strength using Oxford Scale, endurance and repeatability) outcomes. Covariance analysis (ANCOVA) was used to compare the groups using the baseline values as a covariate. Thirty-six women were included in the analysis. There were no differences between the groups for manometry. An increase in the PFM strength, endurance, and repeatability was only observed in the Pilates group. In addition, the Pilates group showed greater adherence to the intervention. Pilates exercise program with PFM contraction is not able to change the PFM strength assessed by manometer in pregnant women, but it improved adherence to the intervention. © 2017 Wiley Periodicals, Inc.

Physiology of a microgravity environment selected contribution: effects of spaceflight during pregnancy on labor and birth at 1 G

NASA Technical Reports Server (NTRS)

Ronca, A. E.; Alberts, J. R.

2000-01-01

The events of parturition (labor, delivery, maternal care, placentophagia, and onset of nursing) were analyzed in female Norway rats (Rattus norvegicus) flown on either 11- or 9-day-long spaceflights beginning at the approximate midpoint of their pregnancies. Each space shuttle flight landed on the 20th day of the rats' pregnancies, just 48-72 h before parturition. After spaceflight, dams were continuously monitored and recorded by time-lapse videography throughout the completion of parturition and onset of nursing (days 22 and 23). Analyses of parturition revealed that, compared with ground controls, flight dams displayed twice the number of lordosis contractions, the predominant labor contraction type in rats. The number of vertical contractions (those that immediately precede expulsion of a pup from the womb), the duration of labor, fetal wastage, number of neonates born, neonatal birth weights, placentophagia, and maternal care during parturition, including the onset of nursing, were comparable in flight and ground control dams. Our findings indicate that, with the exception of labor contractions, mammalian pregnancy and parturition remain qualitatively and quantitatively intact after spaceflight during pregnancy.

41 CFR 302-17.11 - Violation of service agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false Violation of service agreement. 302-17.11 Section 302-17.11 Public Contracts and Property Management Federal Travel Regulation....11 Violation of service agreement. In the event the employee violates the terms of the service...

41 CFR 302-17.11 - Violation of service agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Violation of service agreement. 302-17.11 Section 302-17.11 Public Contracts and Property Management Federal Travel Regulation....11 Violation of service agreement. In the event the employee violates the terms of the service...

48 CFR 619.806 - Pricing the 8(a) contract.

Code of Federal Regulations, 2014 CFR

2014-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619... obtain certified cost or pricing data directly from the 8(a) contractor if the contract is being awarded...

48 CFR 619.806 - Pricing the 8(a) contract.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619... obtain certified cost or pricing data directly from the 8(a) contractor if the contract is being awarded...

48 CFR 619.806 - Pricing the 8(a) contract.

Code of Federal Regulations, 2013 CFR

2013-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619... obtain certified cost or pricing data directly from the 8(a) contractor if the contract is being awarded...

48 CFR 619.806 - Pricing the 8(a) contract.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619... obtain certified cost or pricing data directly from the 8(a) contractor if the contract is being awarded...

Activation-dependent descending reflex evacuation motority of anal canal in rat model.

PubMed

Radomirov, Radomir; Negrev, Negrin; Itzev, Dimitar Evlogiev; Stavreva, Galya

2010-12-01

The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation applied to the anal canal or to the distal part of the rectum elicited tetrodotoxin (10(-7) M)-sensitive frequency-dependent local or descending contractions of the anal canal and the local responses were bigger in amplitude (14.9 ± 1.35 mN) than the descending contractions (5.3 ± 0.7 mN at frequency of 5 Hz, p < 0.05). The balloon-induced distension of the distal rectum evoked descending responses of the anal canal consisting of a short contraction (1.50 ± 0.18 mN) followed by deep relaxation (3.12 ± 0.34 mN). In the presence of atropine (3 x 10(-7) M) the electrically-elicited (5 Hz) local or descending contractions of the anal canal were suppressed and a relaxation revealed. The initial contraction component of the distension-induced response was decreased while the relaxation was not changed. During atropine treatment, spantide (10(-7) M) lowered even more the contractile component of the anal canal response. NG-nitro-L-arginine (5 x 10(-4) M) enhanced the contraction, prevented the atropine-dependent relaxation of the electrically-elicited response and inhibited the distension-induced relaxation. L-Arginine (5 x 10(-4) M) suppressed the contraction and extended the relaxation. ChAT-, substance P- and NADPH-diaphorase-positive perikarya and nerve fibers were observed in myenteric ganglia of the anal canal. The results suggest activation-dependent descending reflex motority of the anal canal involving electrical stimulation-displayed cholinergic and tachykininergic and distension manifested nitrergic neuro-muscular communications.

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (1079 Construction Corp - American Technology Corp.). Part 1

DTIC Science & Technology

1994-03-01

4 YuN0 H CJa- La.0Lm La. 00 0 00oa 0 0 0000 0 N 0’a-4 cy 4 00 0 00 0 0 0000 0 0ON 4 m6U CIO acca anaH )N P. P 0 v N N Nn N CaM i0 111191 CA In S as...P 1 0t In’n’’n’’nl" fI4)4)Il" ffM f Nf I1co0(Go11 0, =.4 NN o0 x- 0 <ý 0C’)V I-In 40 (0 444 4444t444 44444L 0.. 1’ (00e 11 -4L >.. ItJN I-4 4) 1-4 to4

Muscarinic receptor M1 and M2 subtypes in the human eye: QNB, pirenzipine, oxotremorine, and AFDX-116 in vitro autoradiography.

PubMed Central

Gupta, N; McAllister, R; Drance, S M; Rootman, J; Cynader, M S

1994-01-01

Muscarinic cholinergic agents are used to lower intraocular pressure in the medical management of glaucoma and subtypes of muscarinic receptors have now been recognised in many tissues including the eye. To localise muscarinic receptors and their M1 and M2 subtypes in the human eye, in vitro ligand binding and autoradiographic techniques with densitometric quantitation on postmortem eye sections were used. As ligands, [3H] quinuclydinyl benzylate (QNB) (non-subtype specific muscarinic antagonist), [3H]pirenzipine (M1 antagonist), [3H]oxotremorine (M2 muscarinic agonist), [3H]AFDX-116(11[(2[diethylaminomethyl]1-piperidinyl)acetyl]5 , 11dihydro-6H-pyrido [2,3b][1,4]benzodiazepine-6-one) (M2 antagonist) were studied. Specific binding sites for QNB, pirenzipine, and AFDX-116 were localised in the entire ciliary muscle, the iris, and ciliary epithelium. [3H]oxotremorine localised only in the longitudinal portion of the ciliary muscle, and additionally, was not localised in the iris or ciliary epithelium. These results suggest that oxotremorine, by binding selectively to receptors on the longitudinal ciliary muscle and inducing its contraction, may modulate outflow facility independently from accommodation and miosis. Images PMID:7918268

42 CFR 137.239 - If the withdrawing Indian Tribe elects to operate PSFAs carried out under a compact or funding...

Code of Federal Regulations, 2013 CFR

2013-10-01

..., is the resulting contract considered a mature contract under section 4(h) of the Act [25 U.S.C. 450b... agreement under Title V through a contract under Title I, is the resulting contract considered a mature... Title I, the resulting contract is considered a mature contract under section 4(h) of the Act [25 U.S.C...

42 CFR 137.239 - If the withdrawing Indian Tribe elects to operate PSFAs carried out under a compact or funding...

Code of Federal Regulations, 2012 CFR

2012-10-01

..., is the resulting contract considered a mature contract under section 4(h) of the Act [25 U.S.C. 450b... agreement under Title V through a contract under Title I, is the resulting contract considered a mature... Title I, the resulting contract is considered a mature contract under section 4(h) of the Act [25 U.S.C...

42 CFR 137.239 - If the withdrawing Indian Tribe elects to operate PSFAs carried out under a compact or funding...

Code of Federal Regulations, 2014 CFR

2014-10-01

..., is the resulting contract considered a mature contract under section 4(h) of the Act [25 U.S.C. 450b... agreement under Title V through a contract under Title I, is the resulting contract considered a mature... Title I, the resulting contract is considered a mature contract under section 4(h) of the Act [25 U.S.C...

Projections of Demand for Waterborne Transportation, Ohio River Basin, 1980, 1990, 2000, 2020, 2040. Volume 11. Group IX. Feed and Food Products, NEC.

DTIC Science & Technology

1980-12-01

9HIORIVER BASIN 198p, 199, N40, 2029. Prepared for U.S. ARMY CORPS OF ENGINEERS OHIO RIVER DIVISO, HUNTINGTON DISTRICT Contract N DAcW69:78136 by Robert...m c w a 0 %0 -. r, 0 *.. m 0 m 0 0 MI 0% 0 %Dr- 00 HN 0 V4 1 0 I I a, ID %D m .0 4 o 𔃺w0 -Wl N -W 0 H M 0 40 W4 0 N 0 10 0 : C!o 9 11 Ni C!0.-I 0 9...9 ox 0) ON V; .1 C4 .11 at w -I 0 o 4J 0n In ~ Hn In 0CO0 . . 0 4 0 40 0 i 0 0 0D -I 4 14 N N 0’ m 0 40r- N .,I U, mZ 4 0 0 004 H N0 000 CW 0 00 O a

48 CFR 1815.407-2 - Make-or-buy programs. (NASA supplements paragraph (e))

Code of Federal Regulations, 2010 CFR

2010-10-01

... AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 1815.407-2 Make-or-buy programs. (NASA supplements paragraph (e)) (e)(1) Make-or-buy...

Survey of Sea Strait Data Around Japan.

DTIC Science & Technology

1981-07-01

study was financially supported by the Office of Naval Research, Coastal Sciences Program, under contract N00014-809-C-0039, Project No. NR 388-159/9...Objective The principal objective of this study is to review and consolidate existing oceanographic information relating to three major sea straits...these sea straits are shown in Figure 1-1. More specifically, the study called for ccmpiling the following products: 1. Data Inventory System o Search

Role of Adenosine Receptor A2A in Traumatic Optic Neuropathies

DTIC Science & Technology

2012-12-01

in Traumatic Optic Neuropathies ” PRINCIPAL INVESTIGATOR: Gregory I. Liou, PhD CONTRACTING ORGANIZATION: Georgia Health Sciences...Adenosine Receptor A2A in Traumatic Optic Neuropathies 5b. GRANT NUMBER W81XWH-11-2-0046 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...ABSTRACT Our goal is to develop an early therapeutic intervention before the progression of traumatic optic neuropathy (TON), a vision-threatening

Advanced Single-Polymer Nanofiber-Reinforced Composite - Towards Next Generation Ultralight Superstrong/Tough Structural Material

DTIC Science & Technology

2015-04-29

AFRL-OSR-VA-TR-2015-0144 ADVANCED SINGLE-POLYMER NANOFIBER-REINFORCED COMPOSITE YURIS DZENIS UNIVERSITY OF NEBRSKA Final Report 04/29/2015... COMPOSITE - TOWARDS NEXT GENERATION ULTRALIGHT SUPERSTRONG/TOUGH STRUCTURAL MATERIAL 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-11-1-0204 5c. PROGRAM...characterize their mechanical behavior and properties; and (3) fabricate and characterize polyimide nanofiber-reinforced composites . Continuous

Expeditionary Warrior 2012

DTIC Science & Technology

2012-07-23

CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING...ORGANIZATION NAME( S ) AND ADDRESS(ES) Marine Corps Warfighting Laboratory,Wargaming Division,3255 Meyers Avenue (Newlin Hall),Quantico,VA,22134 8...PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S

On the Radiation Effect in Nanostructures Related to Nanomagnetics and Spintronics

DTIC Science & Technology

2015-03-01

COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION...REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11

Australian DefenceScience. Volume 12, Number 3, Spring

DTIC Science & Technology

2004-01-01

Australian DEFENCESCIENCE Spring Issue Volume 12 Number 3 2004 Autonomous UAV flight a world first Missile countermeasures – from flares to lasers...4. TITLE AND SUBTITLE Australian DefenceScience. Volume 12 , Number 3 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public

The Tao of Nelson

DTIC Science & Technology

1998-01-01

ARCHIVE COPY . NATIONAL DEFENSE UNIVERSITY NATIONAL WAR COLLEGE The Tao of Nelson Tao rnvarzably takes no actron, and yet there IS nothing left...1998 to 00-00-1998 4. TITLE AND SUBTITLE The Tao of Nelson 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution

Design for a Manufacturing Method for Memristor-Based Neuromorphic Computing Processors

DTIC Science & Technology

2013-03-01

DESIGN FOR A MANUFACTURING METHOD FOR MEMRISTOR- BASED NEUROMORPHIC COMPUTING PROCESSORS UNIVERSITY OF PITTSBURGH MARCH 2013...BASED NEUROMORPHIC COMPUTING PROCESSORS 5a. CONTRACT NUMBER FA8750-11-1-0271 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER 62788F 6. AUTHOR(S...synapses and implemented a neuromorphic computing system based on our proposed synapse designs. The robustness of our system is also evaluated by

Memristor-Based Synapse Design and Training Scheme for Neuromorphic Computing Architecture

DTIC Science & Technology

2012-06-01

system level built upon the conventional Von Neumann computer architecture [2][3]. Developing the neuromorphic architecture at chip level by...SCHEME FOR NEUROMORPHIC COMPUTING ARCHITECTURE 5a. CONTRACT NUMBER FA8750-11-2-0046 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER 62788F 6...creation of memristor-based neuromorphic computing architecture. Rather than the existing crossbar-based neuron network designs, we focus on memristor

Tailoring the Crystal Structure Toward Optimal Super Conductors

DTIC Science & Technology

2016-06-23

AFRL-AFOSR-VA-TR-2016-0210 TAILORING THE CRYSTAL STRUCTURE TOWARD OPTIMAL SUPERCONDUCTORS Emilia Morosan WILLIAM MARSH RICE UNIV HOUSTON TX Final...TAILORING THE CRYSTAL STRUCTURE TOWARD OPTIMAL SUPERCONDUCTORS 5a. CONTRACT NUMBER FA9550-11-1-0023 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...studied the properties of layered transition metal compounds in search of unconventional superconductors . The aim is to identify ground states competing

Trimaran Resistance Artificial Neural Network

DTIC Science & Technology

2011-01-01

11th International Conference on Fast Sea Transportation FAST 2011, Honolulu, Hawaii, USA, September 2011 Trimaran Resistance Artificial Neural Network Richard...Trimaran Resistance Artificial Neural Network 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e... Artificial Neural Network and is restricted to the center and side-hull configurations tested. The value in the parametric model is that it is able to

Family Studies of Sensorimotor and Neurocognitive Heterogeneity in Autism Spectrum Disorders (ASD)

DTIC Science & Technology

2013-09-01

Autism Spectrum Disorders (ASD) PRINCIPAL INVESTIGATOR: John Sweeney, Ph.D. CONTRACTING ORGANIZATION: University of Texas...in Autism Spectrum Disorders (ASD) 5b. GRANT NUMBER W81XWH-11-1-0738 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) John A. Sweeney, Ph.D.; Matthew W...Southwestern Medical Center Center for Autism and Developmental Disabilities 5323 Harry Hinds Boulevard, MC9086 Dallas, Texas 75390-9086

Products Liability and Tort Risk Distribution in Government Contract Programs

DTIC Science & Technology

1978-09-30

IndemnityStatutes . . . . . . . . . . . . . . . . . . . . .126 E. Swine Flu Immunization Act. . . . . . . . . . . . .126 F. Teton Dam Act...handle 311 discovery and other preliminary matters. Litigation under the Swine Flu Act can be expected to continue for a number of years. F. Teton Dam ...Act On June 5, 1976, the Teton Dam collapsed in Idaho, killing 11 persons, injuring more than 100 -others and causing property 312 damage in excess of

Defense Logistics Agency Can Improve Its Product Quality Deficiency Report Processing

DTIC Science & Technology

2015-07-01

Contracts for M2 Machine Gun Spare Parts in Support of Operations in Southwest Asia,” January 11, 2010 Appendixes DODIG-2015-140 │ 29 Appendix B...personnel are adequately processing product quality deficiency reports and identifying the root cause for defective spare parts . This is the first...quality deficiency report program and prevents meaningful analysis of the primary causes of spare- part quality deficiencies. In addition, the

48 CFR 15.604 - Agency points of contact.

Code of Federal Regulations, 2010 CFR

2010-10-01

... agency: upcoming solicitations; Broad Agency Announcements; Small Business Innovation Research programs; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 15.604 Agency points...

Evolution of H2O related species in the neutral coma of 67P

NASA Astrophysics Data System (ADS)

Bieler, A. M.; Altwegg, K.; Balsiger, H. R.; Bar-Nun, A.; Berthelier, J. J.; Bochsler, P. A.; Briois, C.; Calmonte, U.; Combi, M. R.; De Keyser, J.; van Dishoeck, E.; Fiethe, B.; Fuselier, S. A.; Gasc, S.; Gombosi, T. I.; Hansen, K. C.; Hässig, M.; Jäckel, A.; Kopp, E.; Korth, A.; Le Roy, L.; Mall, U.; Maggiolo, R.; Marty, B.; Mousis, O.; Owen, T. C.; Reme, H.; Rubin, M.; Sémon, T.; Tzou, C. Y.; Waite, J. H., Jr.; Walsh, C.; Wurz, P.

2015-12-01

The ROSINA-DFMS mass spectrometer has been probing the coma of 67Psince the spacecraft arrived at the comet in August 2014.The acquired data set covers a large range of viewing geometries forthe ever changing conditions of 67P along its journey to pericenter. With the high temporal resolutionof ROSINA-DFMS we are able to examine diurnal and seasonal changesof different species in the gaseous coma.Large scale heterogeneities in the coma have been reported since the very first measurements of the neutral inventory at 67P.Many of the minor species are seen to follow one of the major compounds,H2O, CO or CO2.In this paper we will present the latest results on H2O related species.We will discuss the possible trapping/building mechanisms responsible for these species and why it is different from other species such asCO, N2 or CO2. Acknowledgements:Work at the University of Michigan was funded by NASA contract JPL-1266313.Work at UoB was funded by the State of Bern, the Swiss National Science Foundationand the European Space Agency PRODEX Program. Work at MPS was funded by the Max-Planck Society and BMWI contract 50QP1302. Work at Southwest Research institute was supported by subcontract #1496541 from the Jet Propulsion Laboratory. Work at BIRA-IASB was supported by the Belgian Science Policy Office via PRODEX/ROSINA PEA 90020. This work has been carried out thanks to the support of the A*MIDEX project (n° ANR-11-IDEX-0001-02) funded by the « Investissements d'Avenir » French Government program, managed by the French National Research Agency (ANR). This work was supported by CNES grants at IRAP, LATMOS, LPC2E, UTINAM, CRPG, and by the European Research Council (grant no. 267255 to B. Marty). A. Bar-Nun thanks the Ministry of Science and the Israel Space agency. Work by JHW at Southwest Research Institute was funded by the NASA JPL subcontract NAS703001TONMO710889. EvD and CW are supported by A-ERC grant 291141 CHEMPLAN and an NWO Veni award. We acknowledge herewith the work of the whole ESA Rosetta team.

Trends in underweight and overweight/obesity prevalence in Chinese youth, 2004-2009.

PubMed

Seo, Dong-Chul; Niu, Jingjing

2014-08-01

There is a paucity of recent data on Chinese childhood overweight and underweight prevalence especially since 2004. The purpose of this study was to examine trends in underweight and overweight/obesity ("overweight" hereafter) prevalence and energy balance-related behaviors of Chinese youth from 2004 to 2009. Data from the China Health and Nutrition Survey, 2004-2009 (N = 4,061 students aged 6-18 years), were analyzed. Trained health workers took anthropometric measures at the participant's house or at a local clinic following a reference protocol recommended by the World Health Organization. The international age- and sex-specific body mass index reference standard proposed by the International Obesity Task Force was used to define underweight and overweight children in this study. Among 6- to 11-year-old boys, underweight prevalence increased from 14.5% (2004) to 20.1% (2009, p = 0.068). Among 12- to 18-year-old boys, however, overweight prevalence increased from 7.5 to 12.6% (p = 0.034). From 2004 to 2009, after-school sedentary behavior increased from 2.3 to 3.4 h/day for 6- to 11-year-olds (p < 0.001) and from 2.2 to 3.1 h/day for 12- to 18-year-olds (p < 0.01). Meanwhile, the total energy intake decreased 7% for 6- to 11-year-olds (p < 0.05) and 10% for 12- to 18-year-olds (p < 0.01). Both underweight and overweight Chinese students are increasing, with underweight increases more pronounced in 6- to 11-year-olds and overweight increases more pronounced in 12- to 18-year-olds. Nationwide efficacious interventions are needed that improve the diet, decrease sedentary behavior, and encourage a healthy and realistic body image in Chinese youth.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 11. (Kalidescope Shipping, Inc.-Lous Electronics)

DTIC Science & Technology

1989-01-01

0 ( 0 - ( 0 q I - 0 5 0 ) I WOON It -4Z r-44- 5 -N40 142 it I COC of 0I I 000 H9 is :i mo 000 111.~-D~ 0 : It -L -4 moo -4 - C I) N-4...LA 0 0 ɜif IN " 0 1- 0 2 0 LAI 0 0 1- w 1- 2 1-- 1 : I N 11 5 -4 ൾ w c-c M 1.- 0 0 c < Xf. 0 )112E I) D0 01 01 U) Q 0 ) C 0 0 -~ 0 f- i- w 11 z I) iia...8217),- N m - 0 ( 0

Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer

PubMed Central

Tischkowitz, Marc D.; Yilmaz, Ahmet; Chen, Long Q.; Karyadi, Danielle M.; Novak, David; Kirchhoff, Tomas; Hamel, Nancy; Tavtigian, Sean V.; Kolb, Suzanne; Bismar, Tarek A.; Aloyz, Raquel; Nelson, Peter S.; Hood, Lee; Narod, Steven A.; White, Kirsten A.; Ostrander, Elaine A.; Isaacs, William B.; Offit, Kenneth; Cooney, Kathleen A.; Stanford, Janet L.; Foulkes, William D.

2010-01-01

Checkpoint kinase 2 (CHEK2) is a protein involved in arresting cell cycle in response to DNA damage. To investigate whether it plays an important role in the development of prostate cancer (PRCA) in the Ashkenazi Jewish (AJ) population, we sequenced CHEK2 in 75 AJ individuals with prostate, breast, or no cancer (n = 25 each). We identified seven coding SNPs (five are novel) that changed the amino acid sequence, resulting in R3W, E394F, Y424H, S428F, D438Y, P509S, and P509L. We determined the frequency of each variant in 76 AJ families collected by members of the International Consortium for Prostate Cancer Genetics (ICPCG) where ≥ 2 men were affected by PRCA. Only one variant, Y424H in exon 11, was identified in more than two families. Exon 11 was then screened in nine additional AJ ICPCG families (a total of 85 families). The Y424H variant occurred in nine affected cases from four different families; however it did not completely segregate with the disease. We performed bioinformatics analysis, which showed that Y424H is a non-conservative missense substitution that falls at a position that is invariant in vertebrate CHEK2 orthologs. Both SIFT and Align-GVGD predict that Y424H is a loss of function mutation, however the frequency of Y424H was not significantly different between unselected AJ cases from Montreal/Memorial Sloan Kettering Cancer Centre (MSKCC) and AJ controls from Israel/MSKCC (OR 1.18, 95%CI: 0.34–4.61, p=.99). Moreover, functional assays using S. Cerevisae revealed that the Y424H substitution did not alter function of CHEK2 protein. Although we cannot rule out a subtle influence of the CHEK2 variants on PRCA risk, these results suggest that germline CHEK2 mutations have a minor role in PRCA susceptibility in AJ men. PMID:18571837

14 CFR 91.1003 - Management contract between owner and program manager.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Management contract between owner and... RULES Fractional Ownership Operations § 91.1003 Management contract between owner and program manager... the program manager pertaining to the operational safety of the program and those records required to...

42 CFR 52h.9 - What matters must be reviewed for unsolicited contract proposals?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false What matters must be reviewed for unsolicited contract proposals? 52h.9 Section 52h.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN... PROJECTS § 52h.9 What matters must be reviewed for unsolicited contract proposals? (a) Except as otherwise...

Understanding L-H transition in tokamak fusion plasmas

NASA Astrophysics Data System (ADS)

Xu, Guosheng; Wu, Xingquan

2017-03-01

This paper reviews the current state of understanding of the L-H transition phenomenon in tokamak plasmas with a focus on two central issues: (a) the mechanism for turbulence quick suppression at the L-H transition; (b) the mechanism for subsequent generation of sheared flow. We briefly review recent advances in the understanding of the fast suppression of edge turbulence across the L-H transition. We uncover a comprehensive physical picture of the L-H transition by piecing together a number of recent experimental observations and insights obtained from 1D and 2D simulation models. Different roles played by diamagnetic mean flow, neoclassical-driven mean flow, turbulence-driven mean flow, and turbulence-driven zonal flows are discussed and clarified. It is found that the L-H transition occurs spontaneously mediated by a shift in the radial wavenumber spectrum of edge turbulence, which provides a critical evidence for the theory of turbulence quench by the flow shear. Remaining questions and some key directions for future investigations are proposed. This work was supported by National Magnetic Confinement Fusion Science Program of China under Contracts No. 2015GB101000, No. 2013GB106000, and No. 2013GB107000 and National Natural Science Foundation of China under Contracts No. 11575235 and No. 11422546.

Proceedings of the Annual Mechanics of Composites Review (6th),

DTIC Science & Technology

1981-02-01

containing and resisting damage in compression-loaded composite structural components. 176( CONTRACTS INCREMENTAL ANALYSIS OF IMPACT DAMAGE NASI -15888 79...EVALUATION OF THE DURABILITY AND DAMAGE TOLERANCE OF CTOL COMPOS- ITE STRUCTURES NASI -15107 77 October 12 - 80 October 11 Project Engineer: Edward P...DEVELOPMENT OF AN ORTHOTROPIC HOLE ELEMENT NASI -15890 79 July 9 - 80 September 24 Project Engineer: Dr. John H. Crews, Jr. Mail Stop 18BE NASA Langley

Principles of Work Sample Testing. 4. Generalizability

DTIC Science & Technology

1979-04-01

ARI TECHNICAL REPORT TR-79-A11 Principles of Work Sample Testing: IV. Generallzability , by ,lobert M. Guion Gail H. Ironson BOWLING GREEN STATE...UNIVERSITY Bowling Green , Ohio 43403 April 1979 or -Contract DAHC 19-77-C-0007 d CD, LUa.J Prepared for -_J ;=U.S. ARMY RESEARCH INSTITUTE for the...ORGANIZATION NAME AND ADDRESS 10. PROG RAM ELEMENT. PROJECT, TASK A REA & WORK UNIT NUMBERS Bowling Green State University __ Bowling Green , Ohio 43403

Alcohol Intoxication Impact on Outcome from Traumatic Injury

DTIC Science & Technology

2007-05-01

factors for these complications is the severity of the injury, genetic makeup of the individual, the history of alcohol intake of the individual (acute...ethanol as related to trauma in the awake dog. J Trauma 11:76Y86, 1971. 18. Edgarian H, Altura BM: Ethanol and contraction of venous smooth muscle...impact of a 3-day alcohol binge on host responses during trauma/hemorrhage (THem) and following overnight recovery. Methods: Chronically catheterized

Technical Reports Prepared Under Contract N00014-76-C-0475.

DTIC Science & Technology

1987-05-29

264 Approximations to Densities in Geometric H. Solomon 10/27/78 Probability M.A. Stephens 3. Technical Relort No. Title Author Date 265 Sequential ...Certain Multivariate S. Iyengar 8/12/82 Normal Probabilities 323 EDF Statistics for Testing for the Gamma M.A. Stephens 8/13/82 Distribution with...20-85 Nets 360 Random Sequential Coding By Hamming Distance Yoshiaki Itoh 07-11-85 Herbert Solomon 361 Transforming Censored Samples And Testing Fit

Autism and Folate Deficiency

DTIC Science & Technology

2010-05-01

social interaction that remains to be characterized more fully. Conclusion Ablation of genes in the folate pathway may result in abnormal adult...W81XWH-09-1-0246 TITLE: Autism and Folate Deficiency PRINCIPAL INVESTIGATOR: Richard H. Finnell, Ph.D...5a. CONTRACT NUMBER W81XWH-09-1-0246 Autism and Folate Deficiency 5b. GRANT NUMBER AR080064-Concept Award 5c. PROGRAM ELEMENT NUMBER

Synthesis and Functionalization of Atomic Layer Boron Nitride Nanosheets for Advanced Material Applications

DTIC Science & Technology

2014-06-05

PAGES 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 5c. PROGRAM ELEMENT NUMBER 5b. GRANT NUMBER 5a. CONTRACT NUMBER Form Approved OMB...Phys., 89, (2001) 5243. [14] M. Depas, R. L. Van Meirhaegue, W. H. Laflère, F. Cardon , Solid- State Electron, 37, (1994) 433. [15] Muhammad Sajjad

U.S. Air Force Operational Medicine: Using the Enterprise Estimating Supplies Program to Develop Materiel Solutions for the Aeromedical Evacuation In-Flight Kit (FFQDM)

DTIC Science & Technology

2011-05-04

0.04 $12.30 0.04 0.01 $3.08 C 6505013092742UM METOPROLOL TARTRATE INJ 1MG/ML 5ML AMPS 12S AM 3 1 0.03 0.00 $2.39 0.01 0.00 $0.80 A 6505010906797... METOPROLOL TARTRATE TAB 50MG 100S BT 1 1 0.34 0.10 $4.65 0.34 0.10 $4.65 C 6505015055813 MORPHINE SULF INJ 10MG/ML 1ML 10S PG 8 2 2.00 1.20 $82.32 0.50

48 CFR 46.311 - Higher-level contract quality requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Higher-level contract... REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.311 Higher-level contract quality requirement. The contracting officer shall insert the clause at 52.246-11, Higher-Level Contract Quality...

41 CFR 301-11.532 - How should we compute the employee's ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How should we compute the employee's ITRA? 301-11.532 Section 301-11.532 Public Contracts and Property Management Federal...-11.532 How should we compute the employee's ITRA? You should follow the procedures prescribed for the...

41 CFR 101-30.101-11 - Recorded data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Recorded data. 101-30.101-11 Section 101-30.101-11 Public Contracts and Property Management Federal Property Management....1-General § 101-30.101-11 Recorded data. Recorded data means the data which are associated with a...

41 CFR 101-30.101-11 - Recorded data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Recorded data. 101-30.101-11 Section 101-30.101-11 Public Contracts and Property Management Federal Property Management....1-General § 101-30.101-11 Recorded data. Recorded data means the data which are associated with a...

41 CFR 101-30.101-11 - Recorded data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Recorded data. 101-30.101-11 Section 101-30.101-11 Public Contracts and Property Management Federal Property Management....1-General § 101-30.101-11 Recorded data. Recorded data means the data which are associated with a...

41 CFR 101-30.101-11 - Recorded data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Recorded data. 101-30.101-11 Section 101-30.101-11 Public Contracts and Property Management Federal Property Management....1-General § 101-30.101-11 Recorded data. Recorded data means the data which are associated with a...

41 CFR 101-30.101-11 - Recorded data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Recorded data. 101-30.101-11 Section 101-30.101-11 Public Contracts and Property Management Federal Property Management....1-General § 101-30.101-11 Recorded data. Recorded data means the data which are associated with a...

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Bt North America Inc. - Classified Location Domestic)

DTIC Science & Technology

1994-03-01

V4,(41, Or,.in cri nN c >1r- 0 10 f tao oinon0 40 M-4 -4 td n -w toce, of IC 𔃺 0 ca I1-&n UO0 - qtY(DC -04N I- . 30 C S-i Ur’L) . L-M4 U -4~ C...d 0o II Nca( 0 CI400W000 CD 10) Ny It 4. ev MNN.P.P rn If CIL I co00t I’l -4 co0 00000 -00 0 00C) 0 CV 4.4 Me V DCo tD H11 10 004D11 Nm Oin 000000...CO -4 0 11 -2c z .- Z 11 1 CO 0 fm 11 C z 2c z ed C z zx If I ca a 00 11 1- ed tv (d I td III 11 1 00000 11 00-t .- !`ý- W M It r- Ln Ln 0 tma N -4 -4

48 CFR 1602.170-11 - Negotiated benefits contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Negotiated benefits contracts. 1602.170-11 Section 1602.170-11 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL DEFINITIONS OF WORDS AND TERMS...

48 CFR 1602.170-11 - Negotiated benefits contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Negotiated benefits contracts. 1602.170-11 Section 1602.170-11 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL DEFINITIONS OF WORDS AND TERMS...

48 CFR 1602.170-11 - Negotiated benefits contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Negotiated benefits contracts. 1602.170-11 Section 1602.170-11 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL DEFINITIONS OF WORDS AND TERMS...

48 CFR 1602.170-11 - Negotiated benefits contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Negotiated benefits contracts. 1602.170-11 Section 1602.170-11 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL DEFINITIONS OF WORDS AND TERMS...

7 CFR 4288.121 - Contract.

Code of Federal Regulations, 2014 CFR

2014-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions Enrollment Provisions § 4288.121 Contract. Advanced biofuel producers determined to be eligible to.... (a) Contract. The Agency will forward the contract to the advanced biofuel producer. The advanced...

17 CFR 40.11 - Review of event contracts based upon certain excluded commodities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Review of event contracts... COMMODITY FUTURES TRADING COMMISSION PROVISIONS COMMON TO REGISTERED ENTITIES § 40.11 Review of event...) [Reserved] (c) 90-day review and approval of certain event contracts. The Commission may determine, based...

17 CFR 40.11 - Review of event contracts based upon certain excluded commodities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Review of event contracts... COMMODITY FUTURES TRADING COMMISSION PROVISIONS COMMON TO REGISTERED ENTITIES § 40.11 Review of event...) [Reserved] (c) 90-day review and approval of certain event contracts. The Commission may determine, based...

Inventory of File nam.t00z.smartpr12.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 12 hour fcst Dew Point Temperature [K] 003 surface SPFH 12 hour fcst Specific 11 hour fcst Temperature [K] 032 surface TMP 10 hour fcst Temperature [K] 033 surface DPT 11 hour fcst Dew Point Temperature [K] 034 surface DPT 10 hour fcst Dew Point Temperature [K] 035 surface TMAX

Inventory of File nam.t00z.smartak12.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 12 hour fcst Dew Point Temperature [K] 003 surface SPFH 12 hour fcst Specific 11 hour fcst Temperature [K] 032 surface TMP 10 hour fcst Temperature [K] 033 surface DPT 11 hour fcst Dew Point Temperature [K] 034 surface DPT 10 hour fcst Dew Point Temperature [K] 035 surface TMAX

Inventory of File nam.t00z.smarthi12.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 12 hour fcst Dew Point Temperature [K] 003 surface SPFH 12 hour fcst Specific 11 hour fcst Temperature [K] 032 surface TMP 10 hour fcst Temperature [K] 033 surface DPT 11 hour fcst Dew Point Temperature [K] 034 surface DPT 10 hour fcst Dew Point Temperature [K] 035 surface TMAX

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002-1 Contracts under the program. (a) The contracting officer may use FAR part 12 procedures to award a contract for an... process begun as a prototype project under an other transaction agreement or as a research project carried...

Asteroid Lightcurve Analysis at Elephant Head Observatory: 2013 August- October

NASA Astrophysics Data System (ADS)

Alkema, Michael S.

2014-01-01

Photometric observations of two main-belt asteroids, 541 Deborah and 1468 Zomba, were made from Elephant Head Observatory during 2013 August to October. The period and amplitude results are, respectively, P = 29.368 ± 0.005 h, A = 0.10 ± 0.01 mag; P = 2.773 ± 0.001 h, A = 0.34 ± 0.02 mag.

Marshburn removes and replaces the WHC pre-treat tank during in-flight maintenance

NASA Image and Video Library

2013-02-11

ISS034-E-045742 (11 Feb. 2013) --- NASA astronaut Tom Marshburn, Expedition 34 flight engineer, removes and replaces the Waste and Hygiene Compartment (WHC) pretreat tank as part of routine in-flight maintenance in the Tranquility node of the International Space Station.

Further Insight into the Reaction FeO+ + H2 Yields Fe+ + H2O: Temperature Dependent Kinetics, Isotope Effects, and Statistical Modeling (Postprint)

DTIC Science & Technology

2014-07-31

a laminar flow tube via a Venturi inlet, where ∼104 to 105 collisions with a He buffer gas act to thermalize the ions and carry them downstream...ISOTOPE EFFECTS , AND STATISTICAL MODELING (POSTPRINT) Shaun G. Ard, et al. 31 July 2014 Journal Article AIR FORCE RESEARCH LABORATORY Space Vehicles...Kinetics, Isotope Effects , and Statistical Modeling (Postprint) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 61102F 6

78 FR 32413 - Oklahoma; Amendment No. 1 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... adjustments. Further, under this pilot program, FEMA shall obtain any applicable private insurance payments... Services; 97.034, Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048...

[Dynamic of marriage structure in three cities of Ukraine from 1960 to 1992].

PubMed

Timchenko, O I; Omel'chenko, E M; Nikula, E T

2000-04-01

Marriage structure was studied in the city of Kiev and in two cities of the Sumy oblast, Shostka and Trostyanets. Ethnic affiliations and birthplaces of persons contracting marriage were analyzed as the main characteristics of population genetic diversity. The ethnic composition of persons contracting marriage and the proportions of mono- and interethnic marriages remained almost unchanged during one generation. The majority of the persons contracting marriage were Ukrainians (66-91%); among other ethnic groups, only Russians considerably contributed to ethnic diversity (up to 26%). During the period studied, coefficients of marital migration substantially decreased in Kiev (from 0.66-0.82 to 0.34) and Shostka (from 0.72 to 0.52) and changed only insignificantly in Trostyanets. Outbreeding was estimated based on the migration parameters, exogamy level, and marital migration distances. The outbreeding level in the Shostka population (100,000 people) was comparable with that for the considerably larger Kiev population (two million people); however, it was significantly higher than that for the Trostyanets population, the size of which was close to the size of the Shostka population. It is supposed that "migration stress" may unfavorably affect the adaptive genetic structure of the Shostka population.

Human urotensin-II is a potent spasmogen of primate airway smooth muscle

PubMed Central

Hay, Douglas W P; Luttmann, Mark A; Douglas, Stephen A

2000-01-01

The contractile profile of human urotensin-II (hU-II) was examined in primate airway and pulmonary vascular tissues. hU-II contracted tissues from different airway regions with similar potencies (pD2s from 8.6 to 9.2). However, there were regional differences in the efficacy of hU-II, with a progressive increase in the maximum contraction from trachea to smaller airway regions (from 9 to 41% of the contraction to 10 μM carbachol). hU-II potently contracted pulmonary artery tissues from different regions with similar potencies and efficacies: pD2s=8.7 to 9.3 and maximal contractions=79 to 86% of 60 mM KCl. hU-II potently contracted pulmonary vein preparations taken proximal to the atria, but had no effect in tissues from distal to the atria. This is the first report describing the contractile activity of hU-II in airways and suggests that the potential pathophysiological role of this peptide in lung diseases warrants investigation. PMID:10960062

Effects of hypoxia and glucose-removal condition on muscle contraction of the smooth muscles of porcine urinary bladder

PubMed Central

NAGAI, Yuta; KANEDA, Takeharu; MIYAMOTO, Yasuyuki; NURUKI, Takaomi; KANDA, Hidenori; URAKAWA, Norimoto; SHIMIZU, Kazumasa

2015-01-01

To elucidate the dependence of aerobic energy metabolism and utilization of glucose in contraction of urinary bladder smooth muscle, we investigated the changes in the reduced pyridine nucleotide (PNred) fluorescence, representing glycolysis activity, and determined the phosphocreatine (PCr) and ATP contents of the porcine urinary bladder during contractions induced by high K+ or carbachol (CCh) and with and without hypoxia (achieved by bubbling N2 instead of O2) or in a glucose-free condition. Hyperosmotic addition of 65 mM KCl (H-65K+) and 1 µM CCh induced a phasic contraction followed by a tonic contraction. A glucose-free physiological salt solution (PSS) did not change the subsequent contractile responses to H-65K+ and CCh. However, hypoxia significantly attenuated H-65K+- and CCh-induced contraction. H-65K+ and CCh induced a sustained increase in PNred fluorescence, representing glycolysis activity. Hypoxia enhanced H-65K+- and CCh-induced increases in PNred fluorescence, whereas glucose-free PSS decreased these increases, significantly. In the presence of H-65K+, hypoxia decreased the PCr and ATP contents; however, the glucose-free PSS did not change the PCr contents. In conclusion, we demonstrated that high K+- and CCh-induced contractions depend on aerobic metabolism and that an endogenous substrate may be utilized to maintain muscle contraction in a glucose-free PSS in the porcine urinary bladder. PMID:26369431

Effects of hypoxia and glucose-removal condition on muscle contraction of the smooth muscles of porcine urinary bladder.

PubMed

Nagai, Yuta; Kaneda, Takeharu; Miyamoto, Yasuyuki; Nuruki, Takaomi; Kanda, Hidenori; Urakawa, Norimoto; Shimizu, Kazumasa

2016-01-01

To elucidate the dependence of aerobic energy metabolism and utilization of glucose in contraction of urinary bladder smooth muscle, we investigated the changes in the reduced pyridine nucleotide (PNred) fluorescence, representing glycolysis activity, and determined the phosphocreatine (PCr) and ATP contents of the porcine urinary bladder during contractions induced by high K(+) or carbachol (CCh) and with and without hypoxia (achieved by bubbling N2 instead of O2) or in a glucose-free condition. Hyperosmotic addition of 65 mM KCl (H-65K(+)) and 1 µM CCh induced a phasic contraction followed by a tonic contraction. A glucose-free physiological salt solution (PSS) did not change the subsequent contractile responses to H-65K(+) and CCh. However, hypoxia significantly attenuated H-65K(+)- and CCh-induced contraction. H-65K(+) and CCh induced a sustained increase in PNred fluorescence, representing glycolysis activity. Hypoxia enhanced H-65K(+)- and CCh-induced increases in PNred fluorescence, whereas glucose-free PSS decreased these increases, significantly. In the presence of H-65K(+), hypoxia decreased the PCr and ATP contents; however, the glucose-free PSS did not change the PCr contents. In conclusion, we demonstrated that high K(+)- and CCh-induced contractions depend on aerobic metabolism and that an endogenous substrate may be utilized to maintain muscle contraction in a glucose-free PSS in the porcine urinary bladder.

41 CFR 301-11.632 - How should we compute the employee's ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How should we compute the employee's ITRA? 301-11.632 Section 301-11.632 Public Contracts and Property Management Federal... § 301-11.632 How should we compute the employee's ITRA? You should follow the procedures prescribed for...

SUSTAINED ISOMETRIC SHOULDER CONTRACTION ON MUSCULAR STRENGTH AND ENDURANCE: A RANDOMIZED CLINICAL TRIAL.

PubMed

Myers, Natalie L; Toonstra, Jenny L; Smith, Jacob S; Padgett, Cooper A; Uhl, Tim L

2015-12-01

The Advanced Throwers Ten Exercise Program incorporates sustained isometric contractions in conjunction with dynamic shoulder movements. It has been suggested that incorporating isometric holds may facilitate greater increases in muscular strength and endurance. However, no objective evidence currently exists to support this claim. The purpose of this research was to compare the effects of a sustained muscle contraction resistive training program (Advanced Throwers Ten Program) to a more traditional exercise training protocol to determine if increases in shoulder muscular strength and endurance occur in an otherwise healthy population. It was hypothesized that utilizing a sustained isometric hold during a shoulder scaption exercise from the Advanced Throwers Ten would produce greater increases in shoulder strength and endurance as compared to a traditional training program incorporating a isotonic scapular plane abduction (scaption) exercise. Randomized Clinical Trial. Fifty healthy participants were enrolled in this study, of which 25 were randomized into the traditional training group (age: 26 ± 8, height:172 ± 10 cm, weight: 73 ± 13 kg, Marx Activity Scale: 11 ± 4) and 25 were randomized to the Advanced Throwers Ten group (age: 28 ± 9, height: 169 ± 23 cm, weight: 74 ± 16 kg, Marx Activity Scale: 11 ± 5). No pre-intervention differences existed between the groups (P>0.05). Arm endurance and strength data were collected pre and post intervention using a portable load cell (BTE Evaluator, Hanover, MD). Both within and between group analyses were done in order to investigate average torque (strength) and angular impulse (endurance) changes. The traditional and Advanced Throwers Ten groups both significantly improved torque and angular impulse on both the dominant and non-dominant arms by 10-14%. There were no differences in strength or endurance following the interventions between the two training groups (p>0.75). Both training approaches increased strength and endurance as the muscle loads were consistent between protocols indicating that either approach will have positive effects. Level 2.

46 CFR Sec. 11 - Guarantee obligations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 11 Guarantee obligations. (a) Under the provisions of Article 10 of the NSA-LUMPSUMREP Contract...

46 CFR Sec. 11 - Guarantee obligations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 11 Guarantee obligations. (a) Under the provisions of Article 10 of the NSA-LUMPSUMREP Contract...

46 CFR Sec. 11 - Guarantee obligations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 11 Guarantee obligations. (a) Under the provisions of Article 10 of the NSA-LUMPSUMREP Contract...

46 CFR Sec. 11 - Guarantee obligations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 11 Guarantee obligations. (a) Under the provisions of Article 10 of the NSA-LUMPSUMREP Contract...

KSC-2012-4935

NASA Image and Video Library

2012-09-11

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center in Florida, from left, Thomas Keller, program manager with Chenega Security and Support Solutions on the Kennedy Protective Services contract, and Kennedy Space Center Director Robert Cabana stand at attention during the 9/11 memorial dedication ceremony at Fire Station 1. Kennedy Fire and Rescue Services commemorated the 11th anniversary of 9/11 with a ceremony that included a minute of silence at 10:28 a.m., which was the moment of collapse of the north tower of the World Trade Center. Kennedy center-wide emergency units dispatched by Fire Control engaged in one-minute sirens, the new memorial was dedicated and the Honor Guard performed a flag-folding ceremony. Photo credit: NASA/Dimitri Gerondidakis

78 FR 4502 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-22

... Exchange currently charges $0.11 per contract for Customer orders executed at NYSE MKT LLC (``AMEX''), BOX... Customer orders executed at MIAX and $0.57 per contract for Professional, Firm, and Market Maker orders executed at MIAX. As noted above, the Exchange currently charges $0.11 per contract for Customer orders and...

48 CFR 3019.708-70 - Solicitation provision and contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 3019.708-70 Solicitation provision and contract clauses. (a) The contracting officer shall insert the clause at (HSAR) 48 CFR 3052.219-70, Small Business...

An Automated Individual Training Record Management System (Prototype) United States Marine Corps

DTIC Science & Technology

1984-03-01

PERFORMING ORG. REPORT NUMBER 7. AUTHO(a) 9. CONTRACT OR GRANT NUMBER(@) Ronald E. Pruiett David P. Haeusler 9. PERFORMING ORGANIZATION NAME AND ADDRESS...10. PROGRAM ELEMENT. PROJECT. TASK AREA & WORK UNIT NUMBERS Naval Postgraduate School Monterey, CA 93943 11. CONTROL.LING OFFICE NAME AND ADDRESS 12...ane individuel levels of performance . Since the focus is cn individual training ard individual testing, data m s atntained for each individual in a

Doped Boron Carbide-Based Polymers: Fundamental Studies of a Novel Class of Materials for Enhanced Neutron Detection

DTIC Science & Technology

2016-03-01

CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER 9...SPONSORING / MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12

Media and Military Relations during the Mexican War

DTIC Science & Technology

2010-06-11

and Military Relations During the Mexican War 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) MAJ Matthew N...Metzel 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Command and... S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION / AVAILABILITY STATEMENT

Light Matter Interaction on the Nanoscale

DTIC Science & Technology

2016-01-05

Light-Matter Interaction on the Nanoscale 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-10-1-0022 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Xiaoqin...ORGANIZATION NAME( S ) AND ADDRESS(ES) Physics Department University of Texas-Austin 2515 Speedway, Austin, TX, 78712 8. PERFORMING ORGANIZATION REPORT NUMBER...9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) AFOSR 875 N RANDOLPH ST ARLINGTON VA 22203 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR

Air Force Civil Engineer, Volume 12, Number 2, 2004

DTIC Science & Technology

2004-01-01

Volume 12 • No. 2 • 2004 CIVIL ENGINEERAir Force Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection...Section: USAF Facility Energy Management Program. (Air Force Civil Engineer, Volume 12 , Number 02, 2004) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT

Navy/Thomas Nelson Community College MLT Training Pilot Evaluation

DTIC Science & Technology

2002-06-01

4825 Mark Center Drive • Alexandria, Virginia 22311-1850 CAB D0006007.A2/Final June 2002 Navy/Thomas Nelson Community College MLT Training Pilot...Navy/Thomas Nelson Community College MLT Training Pilot Evaluation 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release

Air Force Civil Engineer, Volume 12, Number 1, 2004

DTIC Science & Technology

2004-01-01

Building the ARRK Volume 12 • No. 1 • 2004 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...Air Force Civil Engineer, Volume 12 , Number 01, 2004) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution

How the Defense Logistics Agency Can Help Customers Go Green

DTIC Science & Technology

2010-06-16

ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION /AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13...Logistics Agency Can Help Customers Go Green 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e...TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Defense Logistics Agency,Environmental Office,8725 John J

Integrative Lifecourse and Genetic Analysis of Military Working Dogs

DTIC Science & Technology

2013-10-01

Working Dogs 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-2-0225 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) C. Guillermo Couto, DVM, Diplomate...protocol for the collection of biological samples and Lackland veterinary approval was granted ; and final Lackland AFB oversight approval was granted and...those documents were submitted to DoD CDMRP grant administration. Currently, there is one final approval from ACURO pending (and expected

Drainage Monitoring and Evaluation

DTIC Science & Technology

2011-01-01

CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING...ORGANIZATION NAME( S ) AND ADDRESS(ES) U. S . Army Corps of Engineers,Omaha District ,1616 Capitol Ave,Omaha,NE,98102 8. PERFORMING ORGANIZATION REPORT...NUMBER 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12

48 CFR 1819.7103 - Solicitation provision and contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Rural Area Small Business Plan 1819.7103 Solicitation provision and contract clause. The contracting officer shall insert the clause at 1852.219-74, Use of Rural Area Small Businesses, in solicitations and contracts that offer...

77 FR 75658 - Government In the Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... INTERNATIONAL TRADE COMMISSION [USITC SE-12-034] Government In the Sunshine Act Meeting Notice AGENCY HOLDING THE MEETING: United States International Trade Commission. TIME AND DATE: December 28, 2012 at 11:00 a.m. PLACE: Room 101, 500 E Street SW., Washington, DC 20436, Telephone: (202) 205-2000...

The Ashore Infrastructure Requirments Needed to Support Mobile Maintenance Facilities (MMF) for Intermediate Maintenance on the Next Generation Aircraft Carrier (CVNX)

DTIC Science & Technology

1999-12-01

GENERATION AIRCRAFT CARRIER (CVNX) 6. AUTHOR(S) Watt, Michael R. 5. FUNDING NUMBERS Contract Number 7. PERFORMING ORGANIZATION NAME(S) AND...ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND... ORGANIZATION OF STUDY 5 H. BACKGROUND INFORMATION 9 A. CURRENT MILITARY USERS OF MOBILE FACILITIES 10 1. United States Marine Corps (USMC) 11 2

Breast-feeding is associated with reduced postpartum maternal glucose intolerance after gestational diabetes.

PubMed

O'Reilly, M; Avalos, G; Dennedy, M C; O'Sullivan, E P; Dunne, F P

2012-05-01

Gestational diabetes mellitus (GDM) is associated with adverse foetal and maternal outcomes, and identifies women at risk of future Type 2 Diabetes Mellitus (T2DM). Breast-feeding may improve postpartum maternal glucose tolerance. We prospectively examined the prevalence of postpartum dysglycaemia after GDM and examined the effect of lactation on postpartum glucose tolerance. We compared postpartum 75g oral glucose tolerance test (OGTT) results from 300 women with GDM and 220 controls with normal gestational glucose tolerance (NGT). Breast-feeding data was collected at time of OGTT. Postpartum OGTT results were classified as normal [fasting plasma glucose (FPG) < 5.6mmol/l, 2-h < 7.8 mmol/l] and abnormal [impaired fasting glucose (IFG), FPG 5.6-6.9 mmol/l; impaired glucose tolerance (IGT), 2-h glucose 7.8-11 mmol/l; IFG+IGT; T2DM, FPG > or = 7 mmol/l +/- 2h glucose > or = 11.1 mmol/l]. 6 (2.7%) with NGT in pregnancy had postpartum dysglycaemia compared to 57 (19%) with GDM in index pregnancy (p < 0.001). Non-European ethnicity (OR 3.40, 95% CI 1.45-8.02, p = 0.005), family history of T2DM (OR 2.14, 95% CI 1.06-4.32, p = 0.034) and gestational insulin use (OR 2.62, 95% CI 1.17-5.87 p = 0.019) were associated with persistent dysglycaemia. The prevalence of persistent hyperglycaemia was significantly lower in women who breast-fed versus bottle-fed postpartum (8.2% v 18.4%, p < 0.001). Breast-feeding may confer beneficial metabolic effects after GDM and should be encouraged.

Assessment of Army Contracting Command’s Contract Management Processes (TACOM and RDECOM)

DTIC Science & Technology

2011-04-01

Management Processes (TACOM and RDECOM)” was prepared for and funded by the Acquisition Program, Graduate School of Business & Public Policy, Naval...system and the Evolved Expendable Launch Vehicle rocket program. Rendon has taught contract management courses for the UCLA Government Contracts...program; he was also a senior faculty member for the Keller Graduate School of Management, where he taught MBA courses in project management and

42 CFR 422.506 - Nonrenewal of contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.506 Nonrenewal of contract. (a) Nonrenewal by an MA organization. (1) An MA...

The Effects of DHEA on Resilience to PTSD

DTIC Science & Technology

2011-04-01

Resilience to PTSD Authors Cassandra M. Ellington Scott J. Wright Lolita M. Burrell Michael D. Matthews United States Military Academy...to PTSD 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Cassandra Ellington; Scott Wright; Lolita Burrell; Michael...Chilcoat, H. D., Kessler, R. C., Peterson, E. L., & Lucia, V. C. (1999). Vulnerability to assaultive violence: Further specification of the sex

Near-room-temperature Mid-infrared Photoconductor Signal and Noise Characterization

DTIC Science & Technology

2012-09-01

Near-room-temperature Mid-infrared Photoconductor Signal and Noise Characterization by Justin R. Bickford, Neal K. Bambha, and Wayne H. Chang...Adelphi, MD 20783-1197 ARL-TR-6169 September 2012 Near-room-temperature Mid-infrared Photoconductor Signal and Noise Characterization...temperature Mid-infrared Photoconductor Signal and Noise Characterization 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

15 CFR 734.11 - Government-sponsored research covered by contract controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Government-sponsored research covered by contract controls. 734.11 Section 734.11 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT...

PD-L1 expression in Xp11.2 translocation renal cell carcinoma: Indicator of tumor aggressiveness.

PubMed

Chang, Kun; Qu, Yuanyuan; Dai, Bo; Zhao, Jian-Yuan; Gan, Hualei; Shi, Guohai; Zhu, Yiping; Shen, Yijun; Zhu, Yao; Zhang, Hailiang; Ye, Dingwei

2017-05-18

Programmed death ligand-1 (PD-L1), a promising antitumor target, has proven clinical value against many malignancies. However, the PD-L1 content of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and its correlation with clinical outcomes remain unclear. This study aimed to investigate PD-L1 expression in Xp11.2 RCC and to assess its prognostic value. Formalin-fixed paraffin-embedded specimens from 36 adult patients that were histologically confirmed (by fluorescence in situ hybridization) were subjected to immunohistochemical analysis. Of the 36 Xp11.2 RCC patients, 9 (25.0%) had tumors with positive PD-L1 expression and 27 (75.0%) had tumors with negative PD-L1 expression. Positive PD-L1 expression correlated with advanced tumor stage (P = 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis (P < 0.001). A multivariate analysis identified positive PD-L1 expression was an independent adverse prognostic factor for both progression free survival (hazard ratio: 3.7, P = 0.018) and overall survival (hazard ratio: 4.5, P = 0.034). The median PFS and OS for the whole cohort were 13.0 months (95% confidence interval [CI], 9.4-16.6 months) and 36.0 months (95% CI, 23.9-48.1 months), respectively. Our findings suggest that positive PD-L1 expression is indicative of worse clinical outcome in Xp11.2 RCC. Further studies are needed to explore the potential efficacy of targeting PD-L1 in Xp11.2 RCC.

41 CFR 301-11.624 - What steps must my agency take to determine my ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What steps must my agency take to determine my ITRA? 301-11.624 Section 301-11.624 Public Contracts and Property Management... Responsibilities § 301-11.624 What steps must my agency take to determine my ITRA? Your agency should: (a...

41 CFR 301-11.524 - What steps must my agency take to determine my ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What steps must my agency take to determine my ITRA? 301-11.524 Section 301-11.524 Public Contracts and Property Management... Responsibilities § 301-11.524 What steps must my agency take to determine my ITRA? Your agency should: (a...

Ortho-H2 and the age of prestellar cores

NASA Astrophysics Data System (ADS)

Pagani, L.; Lesaffre, P.; Jorfi, M.; Honvault, P.; González-Lezana, T.; Faure, A.

2013-03-01

Prestellar cores form from the contraction of cold gas and dust material in dark clouds before they collapse to form protostars. Several concurrent theories exist to describe this contraction but they are currently difficult to distinguish. One major difference is the timescale involved in forming the prestellar cores: some theories advocate nearly free-fall speed via, e.g., rapid turbulence decay, while others can accommodate much longer periods to let the gas accumulate via, e.g., ambipolar diffusion. To tell the difference between these theories, measuring the age of prestellar cores could greatly help. However, no reliable clock currently exists. We present a simple chemical clock based on the regulation of the deuteration by the abundance of ortho-H2 that slowly decays away from the ortho-para statistical ratio of 3 down to or less than 0.001. We use a chemical network fully coupled to a hydrodynamical model that follows the contraction of a cloud, starting from uniform density, and reaches a density profile typical of a prestellar core. We compute the N2D+/N2H+ ratio along the density profile. The disappearance of ortho-H2 is tied to the duration of the contraction and the N2D+/N2H+ ratio increases in the wake of the ortho-H2 abundance decrease. By adjusting the time of contraction, we obtain different deuteration profiles that we can compare to the observations. Our model can test fast contractions (from 104 to 106 cm-3 in ~0.5 My) and slow contractions (from 104 to 106 cm-3 in ~5 My). We have tested the sensitivity of the models to various initial conditions. The slow-contraction deuteration profile is approximately insensitive to these variations, while the fast-contraction deuteration profile shows significant variations. We found that, in all cases, the deuteration profile remains clearly distinguishable whether it comes from the fast collapse or the slow collapse. We also study the para-D2H+/ortho-H2D+ ratio and find that its variation is not monotonic, so it does not discriminate between models. Applying this model to L183 (=L134N), we find that the N2D+/N2H+ ratio would be higher than unity for evolutionary timescales of a few megayears independently of other parameters, such as cosmic ray ionization rate or grain size (within reasonable ranges). A good fit to the observations is only obtained for fast contraction (≤0.7 My from the beginning of the contraction and ≤4 My from the birth of the molecular cloud based on the need to keep a high ortho-H2 abundance when the contraction starts - ortho-H2/para-H2 ≥ 0.2 - to match the observations). This chemical clock therefore rules out slow contraction in L183 and steady-state chemical models, since steady state is clearly not reached here. This clock should be applied to other cores to help distinguish slow and fast contraction theories over a large sample of cases. Appendices are available in electronic form at http://www.aanda.org

Evidence for P(2)-purinoceptors contribution in H(2)O(2)-induced contraction of rat aorta in the absence of endothelium.

PubMed

Shen, J Z; Zheng, X F; Kwan, C Y

2000-08-18

H(2)O(2) can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H(2)O(2)-induced vasoconstriction could be functionally attributed to the activation of P(2)-purinoceptors in rat aorta and to explore its possible signaling mechanisms. Isometric tension recording of H(2)O(2) and ATP-induced contractions of rat aortic rings were compared in the absence or presence of various pharmacological tools to identify their possible common signaling pathways. Both H(2)O(2) and ATP induced transient phasic contractions in a concentration-dependent manner (1-1000 microM). Removal of endothelium potentiated the contractile responses to H(2)O(2) and to ATP. H(2)O(2) (30 microM)-induced phasic contraction could be abolished by catalase (800 U/ml), but not affected by SOD (150 U/ml), DMSO (5 mM) and apyrase (5 U/ml), suggesting no involvement of O(2)(-), hydroxyl free radicals and ATP release. Also, several receptor antagonists including phentolamine, atropine, methysergide and chlorpheniramine (each 3 microM) were without effect on H(2)O(2) (30 microM)-induced phasic contraction, suggesting no involvement of typical neurotransmitter release. However, both H(2)O(2) (30 microM) and ATP (1 mM)-induced phasic contractions not only presented homologous desensitization, but also showed heterogeneous desensitization. Furthermore, the phasic contractions in response to H(2)O(2) (30 microM) or ATP (100 microM) could be inhibited or abolished in a concentration dependent manner by RB-2 and suramin (10-100 microM), two widely used P(2)-purinoceptor antagonists, with only partial inhibition by Evans blue (300 microM), a moderately selective P(2x) receptor blocker, or by alpha-beta-methylene-ATP (100 microM), a selective P(2x) receptor desensitizer. On the other hand, both H(2)O(2) (30 microM) and ATP (100 microM)-induced phasic contractions were also attenuated, to different degree, by inhibitors of several enzymes including PLC, PKC, PLA(2) and cyclooxygenase. Lastly, removal of extracellular Ca(2+) or pretreatment with procaine (10 mM) and dantrolene (30 microM), two putative intracellular Ca(2+) release blockers, or with Ni(2+) (100 microM) and tetrandrine (5 microM), two Ca(2+) channel blockers, all significantly inhibited H(2)O(2) and ATP-induced contractions. However, nifedipine (1 microM), a voltage-dependent L-type Ca(2+) channel blocker, was without effect. Our results demonstrate that H(2)O(2)-induced phasic contraction of rat aorta involves, at least in part, the activation of P(2)-purinoceptors in the aortic smooth muscle cells

75 FR 33310 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... Analysis Form 1,034 1 1,034 5.0 5,170 Community Characteristics...... 1,034 1 1,034 1.0 1,034 Health Care Plan (Competing)... 800 1 1,034 4.0 4,136 Health Care Plan (Non- 1,034 1 1,034 2.0 2,068 Competing) Business Plan (Competing)...... 800 1 1,034 4.0 4,136 [[Page 33311

40 CFR Table 34 to Subpart G of... - Fraction Measured (Fm) and Fraction Emitted (Fe) For HAP Compounds in Wastewater Streams

Code of Federal Regulations, 2014 CFR

2014-07-01

...-) 542756 1.00 0.76 Diethyl sulfate 64675 0.0025 0.11 Dimethyl sulfate 77781 0.086 0.079 Dimethylaniline (N,N-) 121697 0.00080 0.34 Dimethylhydrazine (1,1-) 57147 0.38 0.054 Dinitrophenol (2,4-) 51285 0.0077... Hexachlorobutadiene 87683 0.88 0.86 Hexachloroethane 67721 0.50 0.85 Hexane 110543 1.00 1.00 Isophorone 78591 0.51 0...

40 CFR Table 34 to Subpart G of... - Fraction Measured (Fm) and Fraction Emitted (Fe) For HAP Compounds in Wastewater Streams

Code of Federal Regulations, 2011 CFR

2011-07-01

...-) 542756 1.00 0.76 Diethyl sulfate 64675 0.0025 0.11 Dimethyl sulfate 77781 0.086 0.079 Dimethylaniline (N,N-) 121697 0.00080 0.34 Dimethylhydrazine (1,1-) 57147 0.38 0.054 Dinitrophenol (2,4-) 51285 0.0077... Hexachlorobutadiene 87683 0.88 0.86 Hexachloroethane 67721 0.50 0.85 Hexane 110543 1.00 1.00 Isophorone 78591 0.51 0...

40 CFR Table 34 to Subpart G of... - Fraction Measured (Fm) and Fraction Emitted (Fe) For HAP Compounds in Wastewater Streams

Code of Federal Regulations, 2012 CFR

2012-07-01

...-) 542756 1.00 0.76 Diethyl sulfate 64675 0.0025 0.11 Dimethyl sulfate 77781 0.086 0.079 Dimethylaniline (N,N-) 121697 0.00080 0.34 Dimethylhydrazine (1,1-) 57147 0.38 0.054 Dinitrophenol (2,4-) 51285 0.0077... Hexachlorobutadiene 87683 0.88 0.86 Hexachloroethane 67721 0.50 0.85 Hexane 110543 1.00 1.00 Isophorone 78591 0.51 0...

40 CFR Table 34 to Subpart G of... - Fraction Measured (Fm) and Fraction Emitted (Fe) For HAP Compounds in Wastewater Streams

Code of Federal Regulations, 2013 CFR

2013-07-01

...-) 542756 1.00 0.76 Diethyl sulfate 64675 0.0025 0.11 Dimethyl sulfate 77781 0.086 0.079 Dimethylaniline (N,N-) 121697 0.00080 0.34 Dimethylhydrazine (1,1-) 57147 0.38 0.054 Dinitrophenol (2,4-) 51285 0.0077... Hexachlorobutadiene 87683 0.88 0.86 Hexachloroethane 67721 0.50 0.85 Hexane 110543 1.00 1.00 Isophorone 78591 0.51 0...

40 CFR Table 34 to Subpart G of... - Fraction Measured (Fm) and Fraction Emitted (Fe) For HAP Compounds in Wastewater Streams

Code of Federal Regulations, 2010 CFR

2010-07-01

...-) 542756 1.00 0.76 Diethyl sulfate 64675 0.0025 0.11 Dimethyl sulfate 77781 0.086 0.079 Dimethylaniline (N,N-) 121697 0.00080 0.34 Dimethylhydrazine (1,1-) 57147 0.38 0.054 Dinitrophenol (2,4-) 51285 0.0077... Hexachlorobutadiene 87683 0.88 0.86 Hexachloroethane 67721 0.50 0.85 Hexane 110543 1.00 1.00 Isophorone 78591 0.51 0...

24 CFR 880.609 - Adjustment of contract rents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM FOR NEW CONSTRUCTION Management § 880.609 Adjustment of contract rents. (a) Automatic annual adjustment of Contract Rents. Upon...

24 CFR 880.609 - Adjustment of contract rents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM FOR NEW CONSTRUCTION Management § 880.609 Adjustment of contract rents. (a) Automatic annual adjustment of Contract Rents. Upon...

24 CFR 880.609 - Adjustment of contract rents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM FOR NEW CONSTRUCTION Management § 880.609 Adjustment of contract rents. (a) Automatic annual adjustment of Contract Rents. Upon...

24 CFR 880.609 - Adjustment of contract rents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM FOR NEW CONSTRUCTION Management § 880.609 Adjustment of contract rents. (a) Automatic annual adjustment of Contract Rents. Upon...

24 CFR 880.609 - Adjustment of contract rents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM FOR NEW CONSTRUCTION Management § 880.609 Adjustment of contract rents. (a) Automatic annual adjustment of Contract Rents. Upon...

Air Force Needs Better Processes to Appropriately Justify and Manage Cost-Reimbursable Contracts

DTIC Science & Technology

2013-03-21

Contracts Reviewed 4 The Small Business Innovation Research Program 4 Review of Internal Controls 5 ...stimulate high-tech innovation, and increase private-sector commercialization. The SBIR 5 program was established under the Small Business...contracts valued at about $7.4 billion. 5 According to the Office of Federal Procurement Policy, a hybrid contract allows contracting officers to

Age Differences in Dynamic Fatigability and Variability of Arm and Leg Muscles: Associations with Physical Function

PubMed Central

Senefeld, Jonathon; Yoon, Tejin; Hunter, Sandra K.

2016-01-01

Introduction It is not known whether the age-related increase in fatigability of fast dynamic contractions in lower limb muscles also occurs in upper limb muscles. We compared age-related fatigability and variability of maximal-effort repeated dynamic contractions in the knee extensor and elbow flexor muscles; and determined associations between fatigability, variability of velocity between contractions and functional performance. Methods 35 young (16 males; 21.0±2.6 years) and 32 old (18 males; 71.3±6.2 years) adults performed a dynamic fatiguing task involving 90 maximal-effort, fast, concentric, isotonic contractions (1 contraction/3 s) with a load equivalent to 20% maximal voluntary isometric contraction (MVIC) torque with the elbow flexor and knee extensor muscles on separate days. Old adults also performed tests of balance and walking endurance. Results Old adults had greater fatigue-related reductions in peak velocity compared with young adults for both the elbow flexor and knee extensor muscles (P<0.05) with no sex differences (P>0.05). Old adults had greater variability of peak velocity during the knee extensor, but not during the elbow flexor fatiguing task. The age difference in fatigability was greater for the knee extensor muscles (35.9%) compared with elbow flexor muscles (9.7%, P<0.05). Less fatigability of the knee extensor muscles was associated with greater walking endurance (r=−0.34, P=0.048) and balance (r=−0.41, P=0.014) among old adults. Conclusions An age-related increase in fatigability of a dynamic fatiguing task was greater for the knee extensor compared with the elbow flexor muscles in males and females, and greater fatigability was associated with lesser walking endurance and balance. PMID:27989926

7 CFR 1726.403 - Project construction contract closeout.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Project construction contract closeout. 1726.403... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.403 Project construction contract closeout. This section is applicable to contracts executed on...

7 CFR 1726.403 - Project construction contract closeout.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Project construction contract closeout. 1726.403... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.403 Project construction contract closeout. This section is applicable to contracts executed on...

7 CFR 1726.403 - Project construction contract closeout.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 11 2013-01-01 2013-01-01 false Project construction contract closeout. 1726.403... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.403 Project construction contract closeout. This section is applicable to contracts executed on...

7 CFR 1726.403 - Project construction contract closeout.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false Project construction contract closeout. 1726.403... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.403 Project construction contract closeout. This section is applicable to contracts executed on...

7 CFR 1726.403 - Project construction contract closeout.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 11 2012-01-01 2012-01-01 false Project construction contract closeout. 1726.403... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.403 Project construction contract closeout. This section is applicable to contracts executed on...

In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles.

PubMed

Assié, Marie-Bernadette; Dominguez, Hélène; Consul-Denjean, Nathalie; Newman-Tancredi, Adrian

2006-09-01

Interaction with dopamine D2-like receptors plays a major role in the therapeutic effects of antipsychotic drugs. We examined in vivo dopamine D2 receptor occupancy of various established and potential antipsychotics in mouse striatum and olfactory tubercles 1 h after administration of the compound, using [3H]nemonapride as a ligand. All the compounds reduced in vivo binding of [3H]nemonapride in the striatum. When administered systemically, conventional antipsychotics, D2 antagonists, nemonapride (ID50: 0.034 mg/kg), eticlopride (0.047), haloperidol (0.11) and raclopride (0.11) potently inhibited [3H]nemonapride binding. The 'atypical' antipsychotics, risperidone (0.18), ziprasidone (0.38), aripiprazole (1.6), olanzapine (0.99), and clozapine (11.1) were less potent for occupying D2-like receptors. New compounds, displaying marked agonism at 5-HT1A receptors in addition to D2 receptor affinity, exhibited varying D2 receptor occupancy: bifeprunox (0.25), SLV313 (0.78), SSR181507 (1.6) and sarizotan (6.7). ID50 values for inhibition of [3H]nemonapride binding in the striatum correlated with those in the olfactory tubercles (r=0.95, P<0.0001). These values also correlated with previously-reported in vitro affinity of the compounds at rat D2 receptors (r=0.85, P=0.0001) and with inhibition of apomorphine-induced climbing in mice (r=0.79 P=0.0005). In contrast, there was no significant correlation between ID50 values herein and previously-reported ED50 values for catalepsy in mice. These data indicate that: (1) there is no difference in D2 receptor occupancy in limbic versus striatal regions between most classical and atypical or potential antipsychotics; and (2) high occupancy of D2 receptors can be dissociated from catalepsy, if the drugs also activate 5-HT1A receptors. Taken together, these data support the strategy of simultaneously targeting D2 receptor blockade and 5-HT1A receptor activation for new antipsychotics.

LD-PACE II: a new cardiomyostimulator for cardiac bioassist.

PubMed

Chekanov, V S; Chachques, J C; Brum, F; Arzuaga, J; Arzuaga, P; Krum, D P; Hare, J W; Maternowski, M A; Tchekanov, G V; Fiandra, O; Hammond, R; Melamed, V; Chiu, R C; Stephenson, L W

2001-01-01

The LD-PACE II was designed for use in cardiomyoplasty, aortomyoplasty, and skeletal muscle ventricles. All parameters specified as programmable can be changed in a noninvasive manner (using a programming interface wand connected to a computer using the Windows 95/98 environment). Two new functions may be very useful clinically, based on experimental research. 1. Work-rest regimen. The LD-PACE II is able to deliver alternating periods of muscle contractions and rest. Work and rest periods may be programmed independently between 1 and 120 minutes in increments of 1 minute. The work-rest regimen may be useful clinically if muscle contractions are needed for cardiac assist postoperatively. 2. Night/day regimen. This feature allows for a change in the ratio of muscle contractions according to a patient's activity level. During the day the cardiosynchronization ratio may be set from 1:1 to 1:4, and during the night it may be set for 1:8 to 1:16. This allows the muscle to have a long rest period, prevents overuse, and prolongs battery life. These two new features make this cardiomyostimulator very attractive for cardiomyoplasty in particular. The addition of the work-rest and night-day regimens allow the muscle to rest for periods during the day to prevent overuse, subsequent damage, and potential atrophy.

48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

48 CFR 552.216-71 - Economic Price Adjustment-Special Order Program Contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Economic Price Adjustment... Provisions and Clauses 552.216-71 Economic Price Adjustment—Special Order Program Contracts. As prescribed in 516.203-4(a), insert the following clause: Economic Price Adjustment—Special Order Program Contracts...

32 CFR 239.11 - Appeals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ASSISTANCE PROGRAM-APPLICATION PROCESSING § 239.11 Appeals. Applicant appeals will be processed at the District level and forwarded through the MSC, CEMP-CR to the DASA(I&H) for review and consideration. DASA(I...

42 CFR 422.505 - Effective date and term of contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.505 Effective date and term of contract. (a) Effective date. The...

42 CFR 422.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.508 Modification or termination of contract...

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (H E P incicn Biomedicals Inc)

DTIC Science & Technology

1993-01-01

ea -IL. U-’ 4n0) 0)0) 0) it 4 I CO00>-I If f7 )"’.lNNNjNjNNN -IE m J-J NJCA a < 04 0-v 00 a4’ 40000L)O < 11 0 1M 0 -4 110a(w(0w(0(0(W0W0(D( -44 044 U...4 It MO0M It M) 00 NCO-1-10101000tIn N410441- N" 0 00 (0-410 f.-I to 01 11MI C . - aCCa )0 0 0-40000 000001 Ř 4 0 0 00C 0U to 01 11 i i-N N1 N- NN NN

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.510 Termination of contract by CMS. (a) Termination by CMS. CMS may at any...

12 CFR 4.61 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF INFORMATION, CONTRACTING OUTREACH PROGRAM, POST-EMPLOYMENT RESTRICTIONS FOR SENIOR EXAMINERS Minority- , Women- , and Individuals With Disabilities-Owned Business Contracting Outreach Program... the OCC Minority- , Women- , and Individuals with Disabilities-Owned Business Contracting Outreach...

78 FR 11699 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

... additional International Business Reply Service (IBRS) Competitive Contract 3 negotiated service agreement... International Business Reply Service Competitive Contract 3 Negotiated Service Agreement, February 11, 2013.... 684, Order Approving International Business Reply Service Competitive Contract 3 Negotiated Service...

49 CFR 30.11 - Use of solicitation provisions and contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... § 30.15, Restrictions on Federal Public Works Projects, in contractions and solicitations, if— (1) The... contract is awarded during fiscal year 1988. (c) Any contract already awarded that should have contained...

49 CFR 30.11 - Use of solicitation provisions and contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 30.15, Restrictions on Federal Public Works Projects, in contractions and solicitations, if— (1) The... contract is awarded during fiscal year 1988. (c) Any contract already awarded that should have contained...

49 CFR 30.11 - Use of solicitation provisions and contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... § 30.15, Restrictions on Federal Public Works Projects, in contractions and solicitations, if— (1) The... contract is awarded during fiscal year 1988. (c) Any contract already awarded that should have contained...

49 CFR 30.11 - Use of solicitation provisions and contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... § 30.15, Restrictions on Federal Public Works Projects, in contractions and solicitations, if— (1) The... contract is awarded during fiscal year 1988. (c) Any contract already awarded that should have contained...

49 CFR 30.11 - Use of solicitation provisions and contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... § 30.15, Restrictions on Federal Public Works Projects, in contractions and solicitations, if— (1) The... contract is awarded during fiscal year 1988. (c) Any contract already awarded that should have contained...

Lower reinjury rate with a coach-controlled rehabilitation program in amateur male soccer: a randomized controlled trial.

PubMed

Hägglund, Martin; Waldén, Markus; Ekstrand, Jan

2007-09-01

Soccer injuries are common, and athletes returning to play after injury are especially at risk. Few studies have investigated how to prevent reinjury. The rate of reinjury is reduced using a coach-controlled rehabilitation program. Randomized controlled trial; Level of evidence, 1. Twenty-four male amateur soccer teams were randomized into an intervention (n = 282) and control group (n = 300). The intervention was implemented by team coaches and consisted of information about risk factors for reinjury, rehabilitation principles, and a 10-step progressive rehabilitation program including return to play criteria. During the 2003 season, coaches reported individual exposure and all time loss injuries were evaluated by a doctor and a physiotherapist. Four teams (n = 100) withdrew from the study after randomization, leaving 10 teams with 241 players for analysis in both groups. There were 90 injured players (132 injuries) in the intervention group, and 10 of these (11%) suffered 14 reinjuries during the season. In the control group, 23 of 79 injured players (29%) had 40 recurrences (134 injuries). A Cox regression analysis showed a 66% reinjury risk reduction in the intervention group for all injury locations (hazard ratio [HR] 0.34, 95% confidence interval [CI] 0.16-0.72, P = .0047) and 75% for lower limb injuries (HR 0.25, 95% CI 0.11-0.57, P < .001). The preventive effect was greatest within the first week of return to play. Injured players in the intervention group complied with the intervention for 90 of 132 injuries (68%). The reinjury rate in amateur male soccer players was reduced after a controlled rehabilitation program implemented by coaches.

Time Course of Improvements in Power Characteristics in Elite Development Netball Players Entering a Full-Time Training Program.

PubMed

McKeown, Ian; Chapman, Dale W; Taylor, Kristie Lee; Ball, Nick B

2016-05-01

We describe the time course of adaptation to structured resistance training on entering a full-time high-performance sport program. Twelve international caliber female netballers (aged 19.9 ± 0.4 years) were monitored for 18 weeks with countermovement (CMJ: performed with body weight and 15 kg) and drop jumps (0.35-m box at body weight) at the start of each training week. Performance did not improve linearly or concurrently with loaded CMJ power improving 11% by Week 5 (effect size [ES] 0.93 ± 0.72) in contrast, substantial positive changes were observed for unloaded CMJ power (12%; ES 0.78 ± 0.39), and CMJ velocity (unloaded: 7.1%; ES 0.66 ± 0.34; loaded: 7.5%; ES 0.90 ± 0.41) by week 7. Over the investigation duration, large improvements were observed in unloaded CMJ power (24%; ES 1.45 ± 1.11) and velocity (12%; ES 1.13 ± 0.76). Loaded CMJ power also showed a large improvement (19%; ES 1.49 ± 0.97) but only moderate changes were observed for loaded CMJ velocity (8.4%; ES 1.01 ± 0.67). Jump height changes in either unloaded or loaded CMJ were unclear over the 18-week period. Drop jump performance improved throughout the investigation period with moderate positive changes in reactive strength index observed (35%; ES 0.97 ± 0.69). The adaptation response to a structured resistance training program does not occur linearly in young female athletes. Caution should be taken if assessing jump height only, as this will provide a biased observation to a training response. Frequently assessing CMJ performance can aid program design coaching decisions to ensure improvements are seen past the initial neuromuscular learning phase in performance training.

Science Methods by Learning Contract

ERIC Educational Resources Information Center

Heimler, Charles H.; Cunningham, James

1972-01-01

Describes a program employed for teaching a science methods course. The goal of individualized instruction may be achieved by adopting a learning contract system. The appendix includes examples of contracts used in this program. (PS)

41 CFR 50-203.11 - Review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Review. 50-203.11 Section...-Healey Public Contracts Act § 50-203.11 Review. (a) Within twenty (20) days after service of the decision... administrative law judge an original and four copies of a petition for review of the decision. The petition shall...

41 CFR 301-11.300 - When is actual expense reimbursement warranted?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false When is actual expense reimbursement warranted? 301-11.300 Section 301-11.300 Public Contracts and Property Management Federal Travel... session is held; (b) Costs have escalated because of special events (e.g., missile launching periods...

77 FR 65588 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-11 and CP2013-11; Order No. 1514] New Postal...

10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent that...

10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent that...

10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent that...

10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent that...

10 CFR 40.11 - Persons using source material under certain Department of Energy and Nuclear Regulatory...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Persons using source material under certain Department of Energy and Nuclear Regulatory Commission contracts. 40.11 Section 40.11 Energy NUCLEAR REGULATORY... certain Department of Energy and Nuclear Regulatory Commission contracts. Except to the extent that...

41 CFR 301-31.11 - May my agency pay me a per diem allowance instead of actual expenses?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May my agency pay me a per diem allowance instead of actual expenses? 301-31.11 Section 301-31.11 Public Contracts and... TRAVEL EXPENSES 31-THREATENED LAW ENFORCEMENT/INVESTIGATIVE EMPLOYEES § 301-31.11 May my agency pay me a...

A Comparative Study of the Perceived Usefulness of Civilian Institution Contracting-Related Graduate Programs by Graduates and the Perceived Usefulness of the AFIT CAM (Air Force Institute of Technology Contracting and Manufacturing) Program by Graduates

DTIC Science & Technology

1985-09-01

courses for a concentration in procurement and materials management: Procurement and Materials Management Procurement Contract Law Systems Procurement...for contracting in the public sector (Procurement Contract Law ). The respondents did not agree as much with this question as they did with the...the results of this section proved quite different from the group as a whole. Contract Law , Contract Negotiations, Pricing, Procurement Management

Phosphorylation of h1 Calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor

PubMed Central

2012-01-01

Background The timely onset of powerful uterine contractions during parturition occurs through thick and thin filament interactions, similar to other smooth muscle tissues. Calponin is one of the thin filament proteins. Phosphorylation of calponin induced by PKC-epsilon can promote the contraction of vascular smooth muscle. While the mechanism by which calponin regulates the contraction of pregnant myometrium has rarely been explored. Here, we explore whether PKC-epsilon/h1 calponin pathway contribute to regulation of myometrial contractility and development of parturition. Methods We detected the expression of h1 calponin, phosphorylated h1 calponin, PKC-epsilon and phosphorylated PKC-epsilon in the different stages of mice during pregnancy and in labor by the method of western blot and recorded the contraction activity of myometrium strips at the 19th day during pregnancy with different treatments by the organ bath experiments. Results The level of the four proteins including h1 calponin, phosphorylated h1 calponin, PKC-epsilon and phosphorylated PKC-epsilon was significantly increased in pregnant mice myometrium as compared with that in nonpregnant mice. The ratios of phosphorylated h1 calponin/h1 calponin and phosphorylated PKC-epsilon/PKC-epsilon were reached the peak after the onset of labor in myometrium in the mice. After the treatment of more than 10(9-) mol/L Psi-RACK (PKC-epsilon activator), the contractility of myometrium strips from mice was reinforced and the level of phosphorylated h1 calponin increased at the same time which could be interrupted by the specific inhibitor of PKC-epsilon. Meanwhile, the change of the ratio of phosphorylated h1 calponin/h1 calponin was consistent with that of contraction force of mice myometrium strips. Conclusions These data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility. PMID:22551221

An education program about pelvic floor muscles improved women's knowledge but not pelvic floor muscle function, urinary incontinence or sexual function: a randomised trial.

PubMed

de Andrade, Roberta Leopoldino; Bø, Kari; Antonio, Flavia Ignácio; Driusso, Patricia; Mateus-Vasconcelos, Elaine Cristine Lemes; Ramos, Salvador; Julio, Monica Pitanguy; Ferreira, Cristine Homsi Jorge

2018-04-01

Does an educational program with instructions for performing 'the Knack' improve voluntary contraction of the pelvic floor muscles, reduce reports of urinary incontinence, improve sexual function, and promote women's knowledge of the pelvic floor muscles? Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessors. Ninety-nine women from the local community. The experimental group (n=50) received one lecture per week for 4 weeks, and instructions for performing 'the Knack'. The control group (n=49) received no intervention. The primary outcome was maximum voluntary contraction of the pelvic floor muscles measured using manometry. Secondary outcomes were: ability to contract the pelvic floor muscles measured using vaginal palpation; severity of urinary incontinence measured by the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) scored from 0 to 21; self-reported sexual function; and knowledge related to the pelvic floor. Outcomes were measured at baseline and after 4 weeks. The intervention did not significantly improve: maximum voluntary contraction (MD 2.7 cmH 2 O higher in the experimental group, 95% CI -0.5 to 5.9); ability to contract the pelvic floor muscles (RR 2.18, 95% CI 0.49 to 9.65); or self-reported severity of urinary incontinence (MD 1 point greater reduction in the experimental group, 95% CI -3 to 1). Sexual function did not significantly differ between groups, but very few of the women engaged in sexual activity during the study period. The educational program did, however, significantly increase women's knowledge related to the location, functions and dysfunctions of the pelvic floor muscles, and treatment options. Education and teaching women to perform 'the Knack' had no significant effect on voluntary contraction of the pelvic floor muscles, urinary incontinence or sexual function, but it promoted women's knowledge about the pelvic floor. Brazilian Registry of Clinical Trials, RBR-95sxqv. [de Andrade RL, Bø K, Antonio FI, Driusso P, Mateus-Vasconcelos ECL, Ramos S, Julio MP, Ferreira CHJ (2018) An education program about pelvic floor muscles improved women's knowledge but not pelvic floor muscle function, urinary incontinence or sexual function: a randomised trial. Journal of Physiotherapy 64: 91-96]. Copyright © 2018 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

Rothe Development Corporation v. Department of Defense: The Constitutionality of Federal Contracting Programs for Minority-Owned and Other Small Business

DTIC Science & Technology

2009-03-16

not have sufficient evidence to conclude that there was racial discrimination in defense contracting when it reauthorized the program in 2006. This...report examines the Rothe decision in detail; describes existing contracting programs for minority-owned and women -owned small businesses; and analyzes

48 CFR 18.114 - Contracting with the Small Business Administration (The 8(a) Program).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Administration (The 8(a) Program). 18.114 Section 18.114 Federal Acquisition Regulations System... Acquisition Flexibilities 18.114 Contracting with the Small Business Administration (The 8(a) Program). Contracts may be awarded to the Small Business Administration (SBA) for performance by eligible 8(a) firms...

48 CFR 18.114 - Contracting with the Small Business Administration (The 8(a) Program).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Administration (The 8(a) Program). 18.114 Section 18.114 Federal Acquisition Regulations System... Acquisition Flexibilities 18.114 Contracting with the Small Business Administration (The 8(a) Program). Contracts may be awarded to the Small Business Administration (SBA) for performance by eligible 8(a) firms...

42 CFR 51.21 - Contracts for program operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and Priorities § 51.21 Contracts for program operations. (a) An eligible P&A system should work... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program with... capacity to perform protection and advocacy activities throughout the State; (2) The eligible P&A system...