The Inertial Stellar Compass (ISC): A Multifunction, Low Power, Attitude Determination Technology Breakthrough

NASA Technical Reports Server (NTRS)

Bauer, Frank H. (Technical Monitor); Dennehy, Neil; Gambino, Joel; Maynard, Andrew; Brady, T.; Buckley, S.; Zinchuk, J.

2003-01-01

The Inertial Stellar Compass (ISC) is a miniature, low power, stellar inertial attitude determination system with an accuracy of better than 0.1 degree (1 sigma) in three axes. The ISC consumes only 3.5 Watts of power and is contained in a 2.5 kg package. With its embedded on-board processor, the ISC provides attitude quaternion information and has Lost-in-Space (LIS) initialization capability. The attitude accuracy and LIS capability are provided by combining a wide field of view Active Pixel Sensor (APS) star camera and Micro- ElectroMechanical System (MEMS) inertial sensor information in an integrated sensor system. The performance and small form factor make the ISC a useful sensor for a wide range of missions. In particular, the ISC represents an enabling, fully integrated, micro-satellite attitude determination system. Other applications include using the ISC as a single sensor solution for attitude determination on medium performance spacecraft and as a bolt on independent safe-hold sensor or coarse acquisition sensor for many other spacecraft. NASA's New Millennium Program (NMP) has selected the ISC technology for a Space Technology 6 (ST6) flight validation experiment scheduled for 2004. NMP missions, such a s ST6, are intended to validate advanced technologies that have not flown in space in order to reduce the risk associated with their infusion into future NASA missions. This paper describes the design, operation, and performance of the ISC and outlines the technology validation plan. A number of mission applications for the ISC technology are highlighted, both for the baseline ST6 ISC configuration and more ambitious applications where ISC hardware and software modifications would be required. These applications demonstrate the wide range of Space and Earth Science missions that would benefit from infusion of the ISC technology.

An algorithm for enhanced formation flying of satellites in low earth orbit

NASA Astrophysics Data System (ADS)

Folta, David C.; Quinn, David A.

1998-01-01

With scientific objectives for Earth observation programs becoming more ambitious and spacecraft becoming more autonomous, the need for innovative technical approaches on the feasibility of achieving and maintaining formations of spacecraft has come to the forefront. The trend to develop small low-cost spacecraft has led many scientists to recognize the advantage of flying several spacecraft in formation to achieve the correlated instrument measurements formerly possible only by flying many instruments on a single large platform. Yet, formation flying imposes additional complications on orbit maintenance, especially when each spacecraft has its own orbit requirements. However, advances in automation and technology proposed by the Goddard Space Flight Center (GSFC) allow more of the burden in maneuver planning and execution to be placed onboard the spacecraft, mitigating some of the associated operational concerns. The purpose of this paper is to present GSFC's Guidance, Navigation, and Control Center's (GNCC) algorithm for Formation Flying of the low earth orbiting spacecraft that is part of the New Millennium Program (NMP). This system will be implemented as a close-loop flight code onboard the NMP Earth Orbiter-1 (EO-1) spacecraft. Results of this development can be used to determine the appropriateness of formation flying for a particular case as well as operational impacts. Simulation results using this algorithm integrated in an autonomous `fuzzy logic' control system called AutoCon™ are presented.

NASA's 3D Flight Computer for Space Applications

NASA Technical Reports Server (NTRS)

Alkalai, Leon

2000-01-01

The New Millennium Program (NMP) Integrated Product Development Team (IPDT) for Microelectronics Systems was planning to validate a newly developed 3D Flight Computer system on its first deep-space flight, DS1, launched in October 1998. This computer, developed in the 1995-97 time frame, contains many new computer technologies previously never used in deep-space systems. They include: advanced 3D packaging architecture for future low-mass and low-volume avionics systems; high-density 3D packaged chip-stacks for both volatile and non-volatile mass memory: 400 Mbytes of local DRAM memory, and 128 Mbytes of Flash memory; high-bandwidth Peripheral Component Interface (Per) local-bus with a bridge to VME; high-bandwidth (20 Mbps) fiber-optic serial bus; and other attributes, such as standard support for Design for Testability (DFT). Even though this computer system did not complete on time for delivery to the DS1 project, it was an important development along a technology roadmap towards highly integrated and highly miniaturized avionics systems for deep-space applications. This continued technology development is now being performed by NASA's Deep Space System Development Program (also known as X2000) and within JPL's Center for Integrated Space Microsystems (CISM).

Non medical prescribing leads views on their role and the implementation of non medical prescribing from a multi-organisational perspective.

PubMed

Courtenay, Molly; Carey, Nicola; Stenner, Karen

2011-06-02

In the United Kingdom, non-medical prescribing (NMP) has been identified as one way to improve healthcare quality and efficiency. Healthcare organisations are charged with overseeing the clinical governance of NMP and guidance recommends the identification of a lead director to be responsible for its implementation. While over twelve million items are prescribed each year by the 50,000 qualified NMPs its uptake is inconsistent. Several studies have explored the barriers to NMP at a practice level, however little is known about the role the NMP lead and the implementation of NMP from an organisational perspective. The aim of this research was to explore the role of the organisational NMP lead across a range of practice settings within one Strategic Health Authority (SHA) and consider the development of NMP from a multi-organisational perspective. Semi-structured telephone interviews with 28 NMP leads across one SHA were undertaken by a trained qualitative researcher. Interviews addressed the purpose of the role and difficulties encountered; audiotapes were transcribed, coded and themes were identified. The NMP lead role comprised of four main functions; communication, coordinating, clinical governance and support. Factors hampering progress in overseeing the safe development of NMP included lack of clarity about the NMP lead role and responsibilities, strategic support and a lack of protected time. The extent to which clinical governance systems were in place across organisations was inconsistent. Where a strategic approach to its development was adopted, fewer barriers were encountered and NMP was more likely to become embedded within organisations. The significant contribution that NMP leads play in embedding NMP within organisations should be acknowledged by clearer national guidance for this role and its responsibilities. Greater standardisation and consistency is required of clinical governance systems if quality and safety is to be ensured given the expanding development of NMP. The extent to which NMP is in place worldwide differs. However, our findings will be of interest to policymakers in other countries involved in the development and implementation of this role.

Non medical prescribing leads views on their role and the implementation of non medical prescribing from a multi-organisational perspective

PubMed Central

2011-01-01

Background In the United Kingdom, non-medical prescribing (NMP) has been identified as one way to improve healthcare quality and efficiency. Healthcare organisations are charged with overseeing the clinical governance of NMP and guidance recommends the identification of a lead director to be responsible for its implementation. While over twelve million items are prescribed each year by the 50,000 qualified NMPs its uptake is inconsistent. Several studies have explored the barriers to NMP at a practice level, however little is known about the role the NMP lead and the implementation of NMP from an organisational perspective. The aim of this research was to explore the role of the organisational NMP lead across a range of practice settings within one Strategic Health Authority (SHA) and consider the development of NMP from a multi-organisational perspective. Methods Semi-structured telephone interviews with 28 NMP leads across one SHA were undertaken by a trained qualitative researcher. Interviews addressed the purpose of the role and difficulties encountered; audiotapes were transcribed, coded and themes were identified. Results The NMP lead role comprised of four main functions; communication, coordinating, clinical governance and support. Factors hampering progress in overseeing the safe development of NMP included lack of clarity about the NMP lead role and responsibilities, strategic support and a lack of protected time. The extent to which clinical governance systems were in place across organisations was inconsistent. Where a strategic approach to its development was adopted, fewer barriers were encountered and NMP was more likely to become embedded within organisations. Conclusions The significant contribution that NMP leads play in embedding NMP within organisations should be acknowledged by clearer national guidance for this role and its responsibilities. Greater standardisation and consistency is required of clinical governance systems if quality and safety is to be ensured given the expanding development of NMP. The extent to which NMP is in place worldwide differs. However, our findings will be of interest to policymakers in other countries involved in the development and implementation of this role. PMID:21635744

Fact Sheet: N-Methylpyrrolidone (NMP)

EPA Pesticide Factsheets

EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

Comet Borrelly's Varied Landscape

NASA Technical Reports Server (NTRS)

2001-01-01

In this Deep Space 1 image of comet Borrelly, sunlight illuminates the bowling-pin shaped nucleus from directly below. At this distance, many features are become vivid on the surface of the nucleus, including a jagged line between day and night on the comet, rugged terrain on both ends with dark patches, and smooth, brighter terrain near the center. The smallest discernable features are about 110 meters (120 yards) across.

Deep Space 1 completed its primary mission testing ion propulsion and 11 other advanced, high-risk technologies in September 1999. NASA extended the mission, taking advantage of the ion propulsion and other systems to undertake this chancy but exciting, and ultimately successful, encounter with the comet. More information can be found on the Deep Space 1 home page at http://nmp.jpl.nasa.gov/ds1/ .

Deep Space 1 was launched in October 1998 as part of NASA's New Millennium Program, which is managed by JPL for NASA's Office of Space Science, Washington, D.C. The California Institute of Technology manages JPL for NASA.

Concept Definition Study for In-Space Structural Characterization of a Lightweight Solar Array

NASA Technical Reports Server (NTRS)

Woods-Vedeler, Jessica A.; Pappa, Richard S.; Jones, Thomas W.; Spellman, Regina; Scott, Willis; Mockensturm, Eric M.; Liddle, Donn; Oshel, Ed; Snyder, Michael

2002-01-01

A Concept Definition Study (CDS) was conducted to develop a proposed "Lightweight High-Voltage Stretched-Lens Concentrator Solar Array Experiment" under NASA's New Millennium Program Space Technology-6 (NMP ST-6) activity. As part of a multi-organizational team, NASA Langley Research Center's role in this proposed experiment was to lead Structural Characterization of the solar array during the flight experiment. In support of this role, NASA LaRC participated in the CDS to de.ne an experiment for static, dynamic, and deployment characterization of the array. In this study, NASA LaRC traded state-of-the-art measurement approaches appropriate for an in-space, STS-based flight experiment, provided initial analysis and testing of the lightweight solar array and lens elements, performed a lighting and photogrammetric simulation in conjunction with JSC, and produced an experiment concept definition to meet structural characterization requirements.

Non-medical prescribing in New Zealand: an overview of prescribing rights, service delivery models and training.

PubMed

Raghunandan, Rakhee; Tordoff, June; Smith, Alesha

2017-11-01

In this paper, we aim to provide an updated source of information for nonmedical prescribing (NMP) in New Zealand (NZ). A variety of NZ sources were used to collect data: legislation, policy documents and information from professional and regulatory organizations, and education providers. In NZ, the legal categories for prescribers include authorized, designated, and delegated prescribers. Authorized prescribers include dentists, midwives, nurse practitioners, and optometrist prescribers. Designated prescribers include pharmacist prescribers, registered nurse prescribers, and dietitian prescribers. There are no delegated prescribers in NZ at this time. There is variation in the regulation, educational programmes and prescribing competencies used by the different prescribing health professionals involved in NMP in NZ. This update collates relevant information relating to NMP in NZ into one consolidated document and provides policy makers with a current overview of prescribing rights, service delivery models, training requirements, and prescribing competencies used for NMP in NZ. As NMP in NZ continues to expand and evolve, this paper will form a baseline for future NMP research in NZ. NZ needs to develop overarching NMP policy to enable consistency in the various aspects of NMP, thereby delivering a safe and sustainable NMP service in NZ.

Updated Heliostorm Warning Mission: Enhancements Based on New Technology

NASA Technical Reports Server (NTRS)

Young, Roy M.

2010-01-01

The Heliostorm (also referred to as Geostorm) mission has been regarded as the best choice for the first application of solar sail technology. The objective of Heliostorm is to obtain data from an orbit station slightly displaced from the ecliptic at or nearer to the Sun than 0.98 AU, which places it twice as close to the sun as Earth's natural L1 point at 0.993 AU. Heliostorm has been the subject of several mission studies over the past decade, with the most complete study conducted in 1999 in conjunction with a proposed New Millennium Program (NMP) Space Technology 5 (ST-5) flight opportunity. Recently, over a two and one-half year period dating from 2002 through 2005, NASA s In-Space Propulsion Technology Program (ISTP) matured solar sail technology from laboratory components to fully integrated systems, demonstrated in as relevant a space environment as could feasibly be simulated on the ground. Work under this program has yielded promising results for enhanced Heliostorm mission performance. This paper will present the preliminary results of an updated Heliostorm mission design study including the enhancements incorporated during the design, development, analysis and testing of the system ground demonstrator.

Developing a corss-project support system during mission operations: Deep Space 1 extended mission flight control

NASA Technical Reports Server (NTRS)

Scarffe, V. A.

2002-01-01

NASA is focusing on small, low-cost spacecraft for both planetary and earth science missions. Deep Space 1 (DS1) was the first mission to be launched by the NMP. The New Millennium Project (NMP) is designed to develop and test new technology that can be used on future science missions with lower cost and risk. The NMP is finding ways to reduce cost not only in development, but also in operations. DS 1 was approved for an extended mission, but the budget was not large, so the project began looking into part time team members shared with other projects. DS1 launched on October 24, 1998, in it's primary mission it successfully tested twelve new technologies. The extended mission started September 18, 1999 and ran through the encounter with Comet Borrelly on September 22,2001. The Flight Control Team (FCT) was one team that needed to use part time or multi mission people. Circumstances led to a situation where for the few months before the Borrelly encounter in September of 2001 DSl had no certified full time Flight Control Engineers also known as Aces. This paper examines how DS 1 utilized cross-project support including the communication between different projects, and the how the tools used by the Flight Control Engineer fit into cross-project support.

Using missing ordinal patterns to detect nonlinearity in time series data.

PubMed

Kulp, Christopher W; Zunino, Luciano; Osborne, Thomas; Zawadzki, Brianna

2017-08-01

The number of missing ordinal patterns (NMP) is the number of ordinal patterns that do not appear in a series after it has been symbolized using the Bandt and Pompe methodology. In this paper, the NMP is demonstrated as a test for nonlinearity using a surrogate framework in order to see if the NMP for a series is statistically different from the NMP of iterative amplitude adjusted Fourier transform (IAAFT) surrogates. It is found that the NMP works well as a test statistic for nonlinearity, even in the cases of very short time series. Both model and experimental time series are used to demonstrate the efficacy of the NMP as a test for nonlinearity.

Non-medical prescribing in New Zealand: an overview of prescribing rights, service delivery models and training

PubMed Central

Raghunandan, Rakhee; Tordoff, June; Smith, Alesha

2017-01-01

Aim: In this paper, we aim to provide an updated source of information for nonmedical prescribing (NMP) in New Zealand (NZ). Methods: A variety of NZ sources were used to collect data: legislation, policy documents and information from professional and regulatory organizations, and education providers. Results: In NZ, the legal categories for prescribers include authorized, designated, and delegated prescribers. Authorized prescribers include dentists, midwives, nurse practitioners, and optometrist prescribers. Designated prescribers include pharmacist prescribers, registered nurse prescribers, and dietitian prescribers. There are no delegated prescribers in NZ at this time. There is variation in the regulation, educational programmes and prescribing competencies used by the different prescribing health professionals involved in NMP in NZ. Conclusion: This update collates relevant information relating to NMP in NZ into one consolidated document and provides policy makers with a current overview of prescribing rights, service delivery models, training requirements, and prescribing competencies used for NMP in NZ. As NMP in NZ continues to expand and evolve, this paper will form a baseline for future NMP research in NZ. NZ needs to develop overarching NMP policy to enable consistency in the various aspects of NMP, thereby delivering a safe and sustainable NMP service in NZ. PMID:29090084

Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine.

PubMed Central

Akesson, B; Paulsson, K

1997-01-01

OBJECTIVES: To study the acute effects of exposure to the increasingly used solvent, N-methyl-2-pyrrolidone (NMP) in male volunteers. Further, to determine the NMP concentration in plasma and urine during and after the exposure. METHODS: Six male volunteers were exposed for eight hours on four different days to 0, 10, 25, and 50 mg/m3 NMP. Plasma was collected and urine was sampled during and after the exposure. Changes in nasal volume were measured by acoustic rhinometry and in airway resistance by spirometry. RESULTS: The eight-hour experimental exposure to 10, 25, and 50 mg/m3 did not induce discomfort to eyes or upper airways. Acute changes in nasal volume were not found, and no changes in the spirometric data could be registered. The elimination curves suggested a non-linear pattern and at the end of exposure showed mean (range) half lifes of NMP in plasma of about 4.0 (2.9-5.8) hours and in urine 4.5 (3.5-6.6) hours. The unmetabolised NMP found in urine samples collected during exposure and at the subsequent 44 hours corresponded to about 2% of the calculated absorbed dose. At the end of the exposure there was a close correlation between exposures and the plasma concentration and urinary excretion of NMP. CONCLUSIONS: NMP was absorbed through the respiratory tract and readily eliminated from the body, mainly by biotransformation to other compounds. Exposure to 10, 25, or 50 mg/m3 NMP did not cause nose, eye, or airway irritation. Thus, NMP is a mild irritant. PMID:9166128

OPPT workplan risk assessment Methylene Chloride (dichloromethane; CASRN 75-09-2) and N-Methylpyrrolidone (NMP; CASRN 872-50-4)

EPA Science Inventory

These assessments will focus on the use of DCM and NMP in paint stripping. NMP exposures scenarios for this use result in inhalation and dermal exposure to consumers and workers. The low concern for environmental effects of NMP will be discussed in the assessment. In the case of ...

Normothermic ex-situ liver preservation: the new gold standard.

PubMed

Laing, Richard W; Mergental, Hynek; Mirza, Darius F

2017-06-01

Normothermic machine perfusion of the liver (NMP-L) is a novel technology recently introduced into the practice of liver transplantation. This review recapitulates benefits of normothermic perfusion over conventional static cold storage and summarizes recent publications in this area. The first clinical trials have demonstrated both safety and feasibility of NMP-L. They have shown that machine perfusion can entirely replace cold storage or be commenced following a period of cold ischaemia. The technology currently allows transplant teams to extend the period of organ preservation for up to 24 h. Results from the first randomized control trial comparing NMP-L with static cold storage will be available soon. One major advantage of NMP-L technology over other parallel technologies is the potential to assess liver function during NMP-L. Several case series have suggested parameters usable for liver viability testing during NMP-L including bile production and clearance of lactic acidosis. NMP-L allows viability testing of high-risk livers. It has shown the potential to increase utilization of donor organs and improve transplant procedure logistics. NMP-L is likely to become an important technology that will improve organ preservation as well as have the potential to improve utilization of extended criteria donor livers.

Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers.

PubMed

Op den Dries, Sanna; Karimian, Negin; Westerkamp, Andrie C; Sutton, Michael E; Kuipers, Michiel; Wiersema-Buist, Janneke; Ottens, Petra J; Kuipers, Jeroen; Giepmans, Ben N; Leuvenink, Henri G D; Lisman, Ton; Porte, Robert J

2016-07-01

Bile duct injury may occur during liver procurement and transplantation, especially in livers from donation after circulatory death (DCD) donors. Normothermic machine perfusion (NMP) has been shown to reduce hepatic injury compared to static cold storage (SCS). However, it is unknown whether NMP provides better preservation of bile ducts. The aim of this study was to determine the impact of NMP on bile duct preservation in both DCD and non-DCD livers. DCD and non-DCD livers obtained from Lewis rats were preserved for 3 hours using either SCS or NMP, followed by 2 hours ex vivo reperfusion. Biomarkers of bile duct injury (gamma-glutamyltransferase and lactate dehydrogenase in bile) were lower in NMP-preserved livers compared to SCS-preserved livers. Biliary bicarbonate concentration, reflecting biliary epithelial function, was 2-fold higher in NMP-preserved livers (P < 0.01). In parallel with this, the pH of the bile was significantly higher in NMP-preserved livers (7.63 ± 0.02 and 7.74 ± 0.05 for non-DCD and DCD livers, respectively) compared with SCS-preserved livers (7.46 ± 0.02 and 7.49 ± 0.04 for non-DCD and DCD livers, respectively). Scanning and transmission electron microscopy of donor extrahepatic bile ducts demonstrated significantly decreased injury of the biliary epithelium of NMP-preserved donor livers (including the loss of lateral interdigitations and mitochondrial injury). Differences between NMP and SCS were most prominent in DCD livers. Compared to conventional SCS, NMP provides superior preservation of bile duct epithelial cell function and morphology, especially in DCD donor livers. By reducing biliary injury, NMP could have an important impact on the utilization of DCD livers and outcome after transplantation. Liver Transplantation 22 994-1005 2016 AASLD. © 2016 American Association for the Study of Liver Diseases.

Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat.

PubMed

Morgan, T J; Herod, A A; Brain, S A; Chambers, F M; Kandiyoti, R

2005-11-18

Soil from a redundant coke oven site has been examined by extraction of soluble materials using 1-methyl-2-pyrrolidinone (NMP) followed by size exclusion chromatography (SEC) of the extracted material. The extracted material was found to closely resemble a high temperature coal tar pitch. Standard humic and fulvic acids were also examined since these materials are very soluble in NMP and would be extracted with pitch if present in the soil. Humic substances derived from peat samples and NMP-extracts of peats were also examined. The results show that the humic and fulvic substances were not extracted directly by NMP from peats. They were extracted using caustic soda solution and were different from the peat extracts in NMP. These results indicate that humic and fulvic acids were soluble in NMP in the protonated polyelectrolyte form but not in the original native polyelectrolyte form. The extraction of soil using NMP followed by SEC appears to be a promising method for identifying contamination by coal-based industries.

Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone.

PubMed

Bader, Michael; Keener, Stephen A; Wrbitzky, Renate

2005-09-01

The dermal absorption of the solvent N-methyl-2-pyrrolidone (NMP) and its elimination in urine was investigated in an experimental study. Seven volunteers were exposed to 1045 mg of liquid NMP under occlusive conditions for 2 h. Urine was collected before, during and up to 72 h after the exposure and analysed for NMP by GC/MS after liquid-liquid extraction. Additionally, the remaining NMP in the pads was determined to estimate the total dermal uptake. The concentration of NMP in urine increased rapidly after beginning of the exposure up to 1 h after the exposure was completed. A peak concentration of 1,836+/-863 microg/l was observed, the half-life in urine was 3.2 h. About 0.5% of the absorbed dose was excreted metabolically unchanged. An average dermal absorption of 5.5 mg cm(-2) h(-1) was calculated. The results of this study show that the percutaneous absorption of NMP may contribute significantly to the overall uptake of the solvent, e.g. in the workplace. Therefore, a biological monitoring of NMP exposed workers is essential for occupational-medical surveillance.

The Space Technology 5 Power System Design

NASA Technical Reports Server (NTRS)

Stewart, Karen D.; Hernandez-Pellerano, Amri I.

2005-01-01

The Space Technology 5 (ST5) mission is a NASA New Millennium Program (NMP) project that was developed to validate new technologies for future missions and to demonstrate the feasibility of building and launching multiple, miniature spacecraft that can operate as science probes, collecting research quality measurements. The three satellites in the ST5 constellation will be launched into a sun synchronous LEO (Low Earth Orbit) in early 2006. ST5 fits in the 25 kilogram and 24 Watt class of miniature but fully capable spacecraft. The power system design features the use of new technology components and a low voltage power bus. In order to hold the mass and volume low and to qualify new technologies for future use in space, high efficiency triple junction solar cells and a lithium ion battery were baselined into the design. The Power System Electronics (PSE) was designed for a high radiation environment and uses hybrid microcircuits for power switching and over current protection. The ST5 power system architecture and technologies will be presented.

Decision curve analysis assessing the clinical benefit of NMP22 in the detection of bladder cancer: secondary analysis of a prospective trial.

PubMed

Barbieri, Christopher E; Cha, Eugene K; Chromecki, Thomas F; Dunning, Allison; Lotan, Yair; Svatek, Robert S; Scherr, Douglas S; Karakiewicz, Pierre I; Sun, Maxine; Mazumdar, Madhu; Shariat, Shahrokh F

2012-03-01

• To employ decision curve analysis to determine the impact of nuclear matrix protein 22 (NMP22) on clinical decision making in the detection of bladder cancer using data from a prospective trial. • The study included 1303 patients at risk for bladder cancer who underwent cystoscopy, urine cytology and measurement of urinary NMP22 levels. • We constructed several prediction models to estimate risk of bladder cancer. The base model was generated using patient characteristics (age, gender, race, smoking and haematuria); cytology and NMP22 were added to the base model to determine effects on predictive accuracy. • Clinical net benefit was calculated by summing the benefits and subtracting the harms and weighting these by the threshold probability at which a patient or clinician would opt for cystoscopy. • In all, 72 patients were found to have bladder cancer (5.5%). In univariate analyses, NMP22 was the strongest predictor of bladder cancer presence (predictive accuracy 71.3%), followed by age (67.5%) and cytology (64.3%). • In multivariable prediction models, NMP22 improved the predictive accuracy of the base model by 8.2% (area under the curve 70.2-78.4%) and of the base model plus cytology by 4.2% (area under the curve 75.9-80.1%). • Decision curve analysis revealed that adding NMP22 to other models increased clinical benefit, particularly at higher threshold probabilities. • NMP22 is a strong, independent predictor of bladder cancer. • Addition of NMP22 improves the accuracy of standard predictors by a statistically and clinically significant margin. • Decision curve analysis suggests that integration of NMP22 into clinical decision making helps avoid unnecessary cystoscopies, with minimal increased risk of missing a cancer. © 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.

Rapid Quantification of N-Methyl-2-pyrrolidone in Polymer Matrices by Thermal Desorption-GC/MS.

PubMed

Kim, Young-Min; Kim, Jae Woo; Moon, Hye Mi; Lee, Min-Jin; Hosaka, Akihiko; Watanabe, Atsushi; Teramae, Norio; Park, Young-Kwon; Myung, Seung-Woon

2017-01-01

Analysis of a residual solvent in polymeric materials has become an important issue due to the increased regulations and standards for its use. N-Methyl-2-pyrrolidone (NMP) is a solvent widely used in many industries and restricted as one of the chemicals under EU REACH regulations due to its potential harmful effects. In this study, thermal desorption-gas chromatography/mass spectrometry (TD-GC/MS) is applied for the quantitative analysis of NMP with the use of a polymer-coated sample cup. By using the polymer-coated sample cup, the vaporization of NMP was prevented during waiting time before TD-GC/MS analysis. The calibration curve for the TD method showed good linearity (correlation coefficient, r 2 = 0.9998) and precision values (below 5.3% RSD). NMP recovery rates in different polymer matrices (PS, PMMA and PVC) were in the range of 98.8 to 106.6% with RSD values below 5.0%. The quantification result (600 mg NMP/kg PVC) for the blind NMP carrying sample in a PVC matrix by TD-GC/MS was higher than that (532 mg NMP/kg PVC) by solvent extraction-GC/MS method.

Future perspectives on nonmedical prescribing

PubMed Central

Stewart, Derek; Jebara, Tesnime; Cunningham, Scott; Awaisu, Ahmed; Pallivalapila, Abdulrouf; MacLure, Katie

2017-01-01

Many countries have implemented nonmedical prescribing (NMP) and many others are scoping prescribing practices with a view to developing NMP. This paper provides a future perspective on NMP in light of findings of an umbrella review of aspects of NMP. This is followed by coverage of the Scottish Government strategy of pharmacist prescribing and finally, consideration of two key challenges. The review identified seven systematic reviews of influences on prescribing decision-making, processes of prescribing, and barriers and facilitators to implementation. Decision making was reported as complex with many, and often conflicting, influences. Facilitators of NMP included perceived improved patient care and professional autonomy, while barriers included lack of defined roles and resource pressures. Three systematic reviews explored patient outcomes that were noted to be equivalent or better to physician prescribing. In particular, a Cochrane review of 46 studies of clinical, patient-reported, and resource-use outcomes of NMP compared with medical prescribing showed positive intervention-group effects. Despite positive findings, authors highlighted high bias, poor definition and description of ‘prescribing’ and the ‘prescribing process’ and difficulty in separating NMP effects from the contributions of other healthcare team members. While evidence of benefit and safety is essential to inform practice, for NMP to be implemented and sustained on a large scale, there needs to be clear commitment at the highest level. The approach being taken by the Scottish Government to pharmacist prescribing implementation may inform developments in other professions and countries. The vision is that by 2023, all pharmacists providing pharmaceutical care will be pharmacist-independent prescribers. There are, however, challenges to implementing NMP into working practice; two key challenges are the need for sustainable models of care and evaluation research. These challenges could be met by considering the theoretical basis for implementation, and robust and rigorous evaluation. PMID:28607668

Results of NASA's First Autonomous Formation Flying Experiment: Earth Observing-1 (EO-1)

NASA Technical Reports Server (NTRS)

Folta, David C.; Hawkins, Albin; Bauer, Frank H. (Technical Monitor)

2001-01-01

NASA's first autonomous formation flying mission completed its primary goal of demonstrating an advanced technology called enhanced formation flying. To enable this technology, the Guidance, Navigation, and Control center at the Goddard Space Flight Center (GSFC) implemented a universal 3-axis formation flying algorithm in an autonomous executive flight code onboard the New Millennium Program's (NMP) Earth Observing-1 (EO-1) spacecraft. This paper describes the mathematical background of the autonomous formation flying algorithm and the onboard flight design and presents the validation results of this unique system. Results from functionality assessment through fully autonomous maneuver control are presented as comparisons between the onboard EO-1 operational autonomous control system called AutoCon(tm), its ground-based predecessor, and a standalone algorithm.

Inhibition of Osteoclast Differentiation and Bone Resorption by N-Methylpyrrolidone*

PubMed Central

Ghayor, Chafik; Correro, Rita M.; Lange, Katrin; Karfeld-Sulzer, Lindsay S.; Grätz, Klaus W.; Weber, Franz E.

2011-01-01

Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents. Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of N-methylpyrrolidone (NMP) on the regulation of RANKL-induced osteoclastogenesis. NMP inhibited RANKL-induced tartrate-resistant acid phosphatase activity and the formation of tartrate-resistant acid phosphatase-positive multinucleated cells. The RANKL-induced expression of NFATc1 (nuclear factor of activated T cells, cytoplasmic 1) and c-Fos, which are key transcription factors for osteoclastogenesis, was also reduced by treatment with NMP. Furthermore, NMP induced disruption of the actin rings and decreased the mRNAs of cathepsin K and MMP-9 (matrix metalloproteinase-9), both involved in bone resorption. Taken together, these results suggest that NMP inhibits osteoclast differentiation and attenuates bone resorption. Therefore, NMP could prove useful for the treatment of osteoporosis or other bone diseases associated with excessive bone resorption. PMID:21613210

The effect of calcination conditions on the graphitizability of novel synthetic and coal-derived cokes

NASA Astrophysics Data System (ADS)

Bennett, Barbara Ellen

The effects of calcination heating rate and ultimate calcination temperature upon calcined coke and subsequent graphitic material microstructures were studied for materials prepared from three different precursors. The pitch precursors used were Mitsubishi AR pitch (a synthetic, 100% mesophase pitch), the NMP-extracted portion of a raw coal, and the NMP-extracted fraction of a coal liquefaction residue obtained from an HTI pilot plant. These materials were all green-coked under identical conditions. Optical microscopy confirmed that the Mitsubishi coke was very anisotropic and the HTI coke was nearly as anisotropic. The coke produced from the direct coal extract was very isotropic. Crystalline development during calcination heating was verified by high-temperature x-ray diffraction. Experiments were performed to ascertain the effects of varying calcination heating rate and ultimate temperature. It was determined that calcined coke crystallite size increased with increasing temperature for all three materials but was found to be independent of heating rate. The graphene interplanar spacing decreased with increasing temperature for the isotropic NMP-extract material but increased with increasing temperature for the anisotropic materials---Mitsubishi and HTI cokes. Graphene interplanar spacing was also found to be independent of heating rate. Calcined coke real densities were, likewise, found to be independent of heating rate. The anisotropic cokes (Mitsubishi and HTI) exhibited increasing real density with increasing calcination temperature. The NMP-extract coke increased in density up to 1050°C and then suffered a dramatic reduction in real density when heated to 1250°C. This is indicative of puffing. Since there was no corresponding disruption in the crystalline structure, the puffing phenomena was determined to be intercrystalline rather than intracrystalline. After the calcined cokes were graphitized (under identical conditions), the microstructures were re-evaluated. The crystalline properties of the graphitic materials appeared to be independent of calcination conditions---both heating rate and final temperature---for all samples prepared from any given precursor. The calcination step did not influence the microstructure or graphitizability of any of the three materials. The crystallinity of a graphitic material appears to be dictated by the properties of the green coke and cannot be altered by manipulating calcination conditions.

The nuclear matrix protein NMP-1 is the transcription factor YY1.

PubMed Central

Guo, B; Odgren, P R; van Wijnen, A J; Last, T J; Nickerson, J; Penman, S; Lian, J B; Stein, J L; Stein, G S

1995-01-01

NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for the site IV regulatory element of a histone H4 gene. This distal promoter domain is a nuclear matrix interaction site. In the present study, we show that NMP-1 is the multifunctional transcription factor YY1. Gel-shift and Western blot analyses demonstrate that NMP-1 is immunoreactive with YY1 antibody. Furthermore, purified YY1 protein specifically recognizes site IV and reconstitutes the NMP-1 complex. Western blot and gel-shift analyses indicate that YY1 is present within the nuclear matrix. In situ immunofluorescence studies show that a significant fraction of YY1 is localized in the nuclear matrix, principally but not exclusively associated with residual nucleoli. Our results confirm that NMP-1/YY1 is a ubiquitous protein that is present in both human cells and in rat osteosarcoma ROS 17/2.8 cells. The finding that NMP-1 is identical to YY1 suggests that this transcriptional regulator may mediate gene-matrix interactions. Our results are consistent with the concept that the nuclear matrix may functionally compartmentalize the eukaryotic nucleus to support regulation of gene expression. Images Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7479833

[Monograph for N-Methyl-pyrrolidone (NMP) and human biomonitoring values for the metabolites 5-Hydroxy-NMP and 2-Hydroxy-N-methylsuccinimide].

PubMed

2015-10-01

1-Methyl-pyrrolidone (NMP) is used as a solvent in many technical applications. The general population may be exposed to NMP from the use as ingredient in paint and graffiti remover, indoors also from use in paints and carpeting. Because of developmental toxic effects, the use of NMP in consumer products in the EU is regulated. The developmental effects accompanied by weak maternally toxic effects in animal experiments are considered as the critical effects by the German HBM Commission. Based on these effects, HBM-I values of 10 mg/l urine for children and of 15 mg/l for adults, respectively, were derived for the metabolites 5-Hydroxy-NMP and 2-Hydroxy-N-methylsuccinimide. HBM-II-values were set to 30 mg/l urine for children and 50 mg/l for adults, respectively. Because of similar effects of the structural analogue 1-ethyl-2-pyrrolidone (NEP), the possible mixed exposure to both compounds has to be taken into account when evaluating the total burden.

Aggregate development in C 60/N-methyl-2-pyrrolidone solution and its mixture with water as revealed by extraction and mass spectroscopy

NASA Astrophysics Data System (ADS)

Kyzyma, O. A.; Korobov, M. V.; Avdeev, M. V.; Garamus, V. M.; Snegir, S. V.; Petrenko, V. I.; Aksenov, V. L.; Bulavin, L. A.

2010-06-01

The aggregate development in C 60/N-methyl-2-pyrrolidone (C 60/NMP) solution with time is studied by the extraction (hexane) and mass spectroscopy. It is shown that only molecular C 60 in NMP is extracted in hexane, which makes it possible to follow a change in the concentration of non-aggregated fullerene in C 60/NMP during the aggregate growth. It is concluded that almost all fullerene dissolved in NMP is in the aggregates after one month. The reorganization of the aggregates is detected when water is added to the aggregated solution C 60/NMP. Both methods prove that in this case individual fullerene molecules are detached from the aggregates, which contradicts somewhat to complete insolubility of C 60 in water.

Assessing the clinical benefit of nuclear matrix protein 22 in the surveillance of patients with nonmuscle-invasive bladder cancer and negative cytology: a decision-curve analysis.

PubMed

Shariat, Shahrokh F; Savage, Caroline; Chromecki, Thomas F; Sun, Maxine; Scherr, Douglas S; Lee, Richard K; Lughezzani, Giovanni; Remzi, Mesut; Marberger, Michael J; Karakiewicz, Pierre I; Vickers, Andrew J

2011-07-01

Several studies have demonstrated that abnormal levels of nuclear matrix protein 22 (NMP22) are associated with bladder cancer and have led to the approval of NMP22 as a urinary biomarker by the US Food and Drug Administration. Nonetheless, the clinical significance of NMP22 remains unclear. The objective of this study was to use decision analysis to determine whether NMP22 improves medical decision-making. The current study included 2222 patients who had a history of nonmuscle-invasive bladder cancer and current negative cytology. The authors developed models to predict cancer recurrence or progression to muscle-invasive disease using voided NMP22 levels, cystoscopy, age, and sex. Clinical net benefit was calculated by summing the benefits (true-positives), subtracting the harms (false-positives), and weighting these values by the threshold probability at which a patient or clinician would opt for cytoscopy. After cystoscopy, 581 patients (26%) had cancer identified. The NMP22 level was associated significantly with bladder cancer recurrence and progression (P < .001 for both). The use of NMP22 in a model with age and sex was associated with better patient outcomes than performing cystoscopy on everyone and produced threshold probabilities > 8% for recurrence and > 3% for progression. Only offering cystoscopy to those who had a risk > 15% reduced the number of cystoscopies by 229 while missing only 25 cancer recurrences per 1000 men with negative cytology. The current study was limited by its multicenter design. For clinicians who would perform a cystoscopy at a threshold of 5% for recurrence or 1% for progression, NMP22 did not aid clinical decision-making. For less risk-averse clinicians who would only perform a cystoscopy at a threshold probability >thinsp;8% for recurrence or > 3% for progression, NMP22 helped to indicate which patients required cystoscopy and which could be spared this procedure. Copyright © 2011 American Cancer Society.

78 FR 52525 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Public Meetings...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

... Dichloromethane and N-Methylpyrrolidone.'' Dichloromethane and N-Methylpyrrolidone (DCM and NMP) (CASRN 75-09-2... represent and should not be construed to represent any Agency determination or policy. The draft DCM and NMP..., to assemble a panel of experts to evaluate the draft DCM and NMP TSCA risk assessment report for...

High-strength N-methyl-2-pyrrolidone-containing process wastewater treatment using sequencing batch reactor and membrane bioreactor: A feasibility study.

PubMed

Loh, Chun Heng; Wu, Bing; Ge, Liya; Pan, Chaozhi; Wang, Rong

2018-03-01

N-methyl-2-pyrrolidone (NMP) is widely used as a solvent in polymeric membrane fabrication process, its elimination from the process wastewater (normally at a high concentration > 1000 mg/L) prior to discharge is essential because of environmental concern. This study investigated the feasibility of treating high-strength NMP-containing process wastewater in a sequencing batch reactor (SBR; i.e., batch feeding and intermittent aerobic/anoxic condition) and a membrane bioreactor (MBR; i.e., continuous feeding and aeration), respectively. The results showed that the SBR with the acclimated sludge was capable of removing >90% of dissolved organic carbon (DOC) and almost 98% of NMP within 2 h. In contrast, the MBR with the acclimated sludge showed a decreasing NMP removal efficiency from 100% to 40% over 15-day operation. The HPLC and LC-MS/MS analytical results showed that NMP degradation in SBR and MBR could undergo different pathways. This may be attributed to the dissimilar bacterial community compositions in the SBR and MBR as identified by 16s rRNA gene sequencing analysis. Interestingly, the NMP-degrading capability of the activated sludge derived from MBR could be recovered to >98% after they were operated at the SBR mode (batch feeding mode with intermittent aerobic/anoxic condition). This study reveals that SBR is probably a more feasible process to treat high-strength NMP-containing wastewater, but residual NMP metabolites in the SBR effluent need to be post-treated by an oxidation or adsorption process in order to achieve zero-discharge of toxic chemicals. Copyright © 2017 Elsevier Ltd. All rights reserved.

Psychometric evaluation of Persian Nomophobia Questionnaire: Differential item functioning and measurement invariance across gender.

PubMed

Lin, Chung-Ying; Griffiths, Mark D; Pakpour, Amir H

2018-03-01

Background and aims Research examining problematic mobile phone use has increased markedly over the past 5 years and has been related to "no mobile phone phobia" (so-called nomophobia). The 20-item Nomophobia Questionnaire (NMP-Q) is the only instrument that assesses nomophobia with an underlying theoretical structure and robust psychometric testing. This study aimed to confirm the construct validity of the Persian NMP-Q using Rasch and confirmatory factor analysis (CFA) models. Methods After ensuring the linguistic validity, Rasch models were used to examine the unidimensionality of each Persian NMP-Q factor among 3,216 Iranian adolescents and CFAs were used to confirm its four-factor structure. Differential item functioning (DIF) and multigroup CFA were used to examine whether males and females interpreted the NMP-Q similarly, including item content and NMP-Q structure. Results Each factor was unidimensional according to the Rach findings, and the four-factor structure was supported by CFA. Two items did not quite fit the Rasch models (Item 14: "I would be nervous because I could not know if someone had tried to get a hold of me;" Item 9: "If I could not check my smartphone for a while, I would feel a desire to check it"). No DIF items were found across gender and measurement invariance was supported in multigroup CFA across gender. Conclusions Due to the satisfactory psychometric properties, it is concluded that the Persian NMP-Q can be used to assess nomophobia among adolescents. Moreover, NMP-Q users may compare its scores between genders in the knowledge that there are no score differences contributed by different understandings of NMP-Q items.

Preliminary Results of NASA's First Autonomous Formation Flying Experiment: Earth Observing-1 (EO-1)

NASA Technical Reports Server (NTRS)

Folta, David; Hawkins, Albin

2001-01-01

NASA's first autonomous formation flying mission is completing a primary goal of demonstrating an advanced technology called enhanced formation flying. To enable this technology, the Guidance, Navigation, and Control center at the Goddard Space Flight Center has implemented an autonomous universal three-axis formation flying algorithm in executive flight code onboard the New Millennium Program's (NMP) Earth Observing-1 (EO-1) spacecraft. This paper describes the mathematical background of the autonomous formation flying algorithm and the onboard design and presents the preliminary validation results of this unique system. Results from functionality assessment and autonomous maneuver control are presented as comparisons between the onboard EO-1 operational autonomous control system called AutoCon(tm), its ground-based predecessor, and a stand-alone algorithm.

Whole Person Learning: Embedding Ethical Enterprise Leadership in Business Education

ERIC Educational Resources Information Center

Carter, E. Vincent; Donohue, Mary

2012-01-01

This study introduces a collaborative business education curricular design known as "whole person learning." The post-financial crisis market environment requires business education to encompass curricular, commercial and community skills. Drawing on the Toronto based National Mentoring Program (NMP), "whole person learning"…

Traumatic brain injury with a machete penetrating the dura and brain: Case report from southeast Mexico.

PubMed

Del Castillo-Calcáneo, Juan D; Bravo-Angel, Ulises; Mendez-Olan, Raúl; Rodriguez-Valencia, Francisco; Valdés-García, Javier; García-González, Ulises; Broc-Haro, Guy G

2016-01-01

Traumatic Brain Injury (TBI) is a major cause of death and disability in our society, we present the first case report of non-missile penetrating (NMP) cranial trauma with a machete in Mexico, and our objective by presenting this case is to prove the usefulness of recently proposed algorithms in the treatment of NMP PRESENTATION OF CASE: We present the case of a 47 year old woman who received a machete hit to the right side of her head during an assault., she arrived fully conscious to the emergency department (ED), computed tomography was performed and based on the findings of this study and in accordance to recently proposed algorithms for managing NMP cranial trauma a craniotomy was performed, at follow-up the patient presented wtih minor neurological disability in the form of left hemiparesis. Non-missile penetrating (NMP) lesions are defined as having an impact velocity of less than 100m/s, causing injury by laceration and maceration, An algorithm for treating NMP cranial trauma has been recently published in the Journal World Neurosurgery by De Holanda et al., in this case we followed the algorithm in order to provide best care available for our patient with good results. The use of current algorithms for managing NMP cranial trauma has proved to be very useful when applied on this particular case. GCS on admission is an important prognostic factor in NMP cranial trauma. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Comet Borrelly Slows Solar Wind

NASA Technical Reports Server (NTRS)

2001-01-01

Over 1300 energy spectra taken on September 22, 2001 from the ion and electron instruments on NASA's Deep Space 1 span a region of 1,400,000 kilometers (870,000 miles) centered on the closest approach to the nucleus of comet Borrelly. A very strong interaction occurs between the solar wind (horizontal red bands to left and right in figure) and the comet's surrounding cloud of dust and gas, the coma. Near Deep Space 1's closest approach to the nucleus, the solar wind picked up charged water molecules from the coma (upper green band near the center), slowing the wind sharply and creating the V-shaped energy structure at the center.

Deep Space 1 completed its primary mission testing ion propulsion and 11 other advanced, high-risk technologies in September 1999. NASA extended the mission, taking advantage of the ion propulsion and other systems to undertake this chancy but exciting, and ultimately successful, encounter with the comet. More information can be found on the Deep Space 1 home page at http://nmp.jpl.nasa.gov/ds1/ .

Deep Space 1 was launched in October 1998 as part of NASA's New Millennium Program, which is managed by JPL for NASA's Office of Space Science, Washington, D.C. The California Institute of Technology manages JPL for NASA.

Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.

PubMed

Saw, Constance Lay Lay; Heng, Paul Wan Sia; Chin, William Wei Lim; Soo, Khee Chee; Olivo, Malini

2006-07-08

Hypericin (HY) was examined for photodynamic therapy (PDT)-induced vascular damage using the chick chorioallantoic membrane (CAM) model. Clinically, plasma protein was used to solubilize HY. Upon binding to albumin, free HY available to be transported through the membrane may be limited. Hence, formulations containing a biocompatible solvent, N-Methyl pyrrolidone (NMP), have the potential to enhance HY delivery into solid tumors. At suitable concentrations, NMP and/or light irradiation did not produce antivascular damage. Hypericin-PDT effects showed to be HY and NMP concentrations-dependent. These findings indicate that NMP is a promising solvent and penetration enhancer for HY-PDT clinical applications.

The novel fluorescent CDP-analogue (Pbeta)MABA-CDP is a specific probe for the NMP binding site of UMP/CMP kinase.

PubMed

Rudolph, M G; Veit, T J; Reinstein, J

1999-12-01

Direct thermodynamic and kinetic investigations of the binding of nucleotides to the nucleoside monophosphate (NMP) site of NMP kinases have not been possible so far because a spectroscopic probe was not available. By coupling a fluorescent N-methylanthraniloyl- (mant) group to the beta-phosphate of CDP via a butyl linker, a CDP analogue [(Pbeta)MABA-CDP] was obtained that still binds specifically to the NMP site of UmpKdicty, because the base and the ribose moieties, which are involved in specific interactions, are not modified. This allows the direct determination of binding constants for its substrates in competition experiments.

The novel fluorescent CDP-analogue (Pbeta)MABA-CDP is a specific probe for the NMP binding site of UMP/CMP kinase.

PubMed Central

Rudolph, M. G.; Veit, T. J.; Reinstein, J.

1999-01-01

Direct thermodynamic and kinetic investigations of the binding of nucleotides to the nucleoside monophosphate (NMP) site of NMP kinases have not been possible so far because a spectroscopic probe was not available. By coupling a fluorescent N-methylanthraniloyl- (mant) group to the beta-phosphate of CDP via a butyl linker, a CDP analogue [(Pbeta)MABA-CDP] was obtained that still binds specifically to the NMP site of UmpKdicty, because the base and the ribose moieties, which are involved in specific interactions, are not modified. This allows the direct determination of binding constants for its substrates in competition experiments. PMID:10631985

Synthesis of NMP, a Fluoxetine (Prozac) Precursor, in the Introductory Organic Laboratory

NASA Astrophysics Data System (ADS)

Perrine, Daniel M.; Sabanayagam, Nathan R.; Reynolds, Kristy J.

1998-10-01

A synthesis of the immediate precursor of the widely used antidepressant fluoxetine (Prozac) is described. The procedure is short, safe, and simple enough to serve as a laboratory exercise for undergraduate students in the second semester of introductory organic chemistry and is one which will be particularly interesting to those planning a career in the health sciences. The compound synthesized is (°)-N,N-dimethyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, or "N-methyl Prozac" (NMP). The synthesis of NMP requires one two-hour period and a second three-hour period. In the first period, a common Mannich base, 3-dimethylaminopropiophenone, is reduced with sodium borohydride to form (°)-3-dimethylamino-1-phenylpropanol. In the second period, potassium t-butoxide is used to couple (°)-3-dimethylamino-1-phenylpropanol with p-chlorotrifluoromethylbenzene to form NMP, which is isolated as its oxalate salt. All processes use equipment and materials that are inexpensive and readily available in most undergraduate laboratories. Detailed physical data are given on NMP, including high-field DEPT 13C NMR.

Space Technology 5: Pathfinder for Future Micro-Sat Constellations

NASA Technical Reports Server (NTRS)

Carlisle, Candace; Finnegan, Eric

2004-01-01

The Space Technology 5 (ST-5) Project, currently in the implementation phase, is part of the National Aeronautics and Space Administration (NASA) s New Millennium Program (NMP). ST-5 will consist of a constellation of three miniature satellites, each with mass less than 25 kg and size approximately 60 cm by 30 cm. ST-5 addresses technology challenges, as well as fabrication, assembly, test and operations strategies for future micro-satellite missions. ST-5 will be deployed into a highly eccentric, geo-transfer orbit (GTO). This will expose the spacecraft to a high radiation environment as well as provide a low level magnetic background. A three-month flight demonstration phase is planned to validate the technologies and demonstrate concepts for future missions. Each ST-5 spacecraft incorporates NMP competitively-selected breakthrough technologies. These include Cold Gas Micro-Thrusters for propulsion and attitude control, miniature X-band transponder for space-ground communications, Variable Emittance Coatings for dynamic thermal control, and CULPRiT ultra low power logic chip used for Reed-Solomon encoding. The ST-5 spacecraft itself is a technology that can be infused into future missions. It is a fully functional micro-spacecraft built within tight volume and mass constraints. It is built to withstand a high radiation environment, large thermal variations, and high launch loads. The spacecraft power system is low-power and low-voltage, and is designed to turn on after separation &om the launch vehicle. Some of the innovations that are included in the ST-5 design are a custom spacecraft deployment structure, magnetometer deployment boom, nutation damper, X-band antenna, miniature spinning sun sensor, solar array with triple junction solar cells, integral card cage assembly containing single card Command and Data Handling and Power System Electronics, miniature magnetometer, and lithium ion battery. ST-5 will demonstrate the ability of a micro satellite to perform research-quality science. Each ST-5 spacecraft will deploy a precision magnetometer to be used both for attitude determination and as a representative science instrument. The spacecraft has been developed with a low magnetic signature to avoid interference with the magnetometer. The spacecraft will be able to detect and respond autonomously to science events, i.e. significant changes in the magnetic field measurements. The three spacecraft will be a pathfinder for future constellation missions. They will be deployed to demonstrate an appropriate geometry for scientific measurements as a constellation. They will be operationally managed as a constellation, demonstrating automation and communication strategies that will be useful for future missions. The technologies and future mission concepts will be validated both on the ground and in space. Technologies will be validated on the ground by a combination of component level and system level testing of the flight hardware in a thermal vacuum environment. In flight, specific validation runs are planned for each of the technologies. Each validation run consists of one or more orbits with a specific validation objective. This paper will describe the ST-5 mission, and the applicability of the NMP technologies, spacecraft, and mission concepts to future missions. It will also discuss the validation approach for the ST-5 technologies and mission concepts.

Exploring Spaces for Learning: Using Narrative Mediation Path to Improve the Academic Performance of Underachieving Undergraduate Students

ERIC Educational Resources Information Center

Crowley, Una; Mahon, Catherine

2012-01-01

Learning to learn has been identified as a key educational competence. Over the next two years, as part of the INSTALL project, NUI Maynooth is testing the effectiveness of an exploratory group technique, the Narrative Mediation Path (NMP), which has been developed to promote reflective thinking skills. To date, interviews have been conducted with…

Lessons in weather data interoperability: the National Mesonet Program

NASA Astrophysics Data System (ADS)

Evans, J. D.; Werner, B.; Cogar, C.; Heppner, P.

2015-12-01

The National Mesonet Program (NMP) links local, state, and regional surface weather observation networks (a.k.a. mesonets) to enhance the prediction of high-impact, local-scale weather events. A consortium of 23 (and counting) private firms, state agencies, and universities provides near-real-time observations from over 7,000 fixed weather stations, and over 1,000 vehicle-mounted sensors, every 15 minutes or less, together with the detailed sensor and station metadata required for effective forecasts and decision-making. In order to integrate these weather observations across the United States, and to provide full details about sensors, stations, and observations, the NMP has defined a set of conventions for observational data and sensor metadata. These conventions address the needs of users with limited bandwidth and computing resources, while also anticipating a growing variety of sensors and observations. For disseminating weather observation data, the NMP currently employs a simple ASCII format derived from the Integrated Ocean Observing System. This simplifies data ingest into common desktop software, and parsing by simple scripts; and it directly supports basic readings of temperature, pressure, etc. By extending the format to vector-valued observations, it can also convey readings taken at different altitudes (e.g. windspeed) or depths (e.g., soil moisture). Extending beyond these observations to fit a greater variety of sensors (solar irradiation, sodar, radar, lidar) may require further extensions, or a move to more complex formats (e.g., based on XML or JSON). We will discuss the tradeoffs of various conventions for different users and use cases. To convey sensor and station metadata, the NMP uses a convention known as Starfish Fungus Language (*FL), derived from the Open Geospatial Consortium's SensorML standard. *FL separates static and dynamic elements of a sensor description, allowing for relatively compact expressions that reference a library of shared definitions (e.g., sensor manufacturer's specifications) alongside time-varying and site-specific details (slope / aspect, calibration, etc.) We will discuss the tradeoffs of *FL, SensorML, and alternatives for conveying sensor details to various users and uses.

Effect of Nutrient Management Planning on Crop Yield, Nitrate Leaching and Sediment Loading in Thomas Brook Watershed

NASA Astrophysics Data System (ADS)

Amon-Armah, Frederick; Yiridoe, Emmanuel K.; Ahmad, Nafees H. M.; Hebb, Dale; Jamieson, Rob; Burton, David; Madani, Ali

2013-11-01

Government priorities on provincial Nutrient Management Planning (NMP) programs include improving the program effectiveness for environmental quality protection, and promoting more widespread adoption. Understanding the effect of NMP on both crop yield and key water-quality parameters in agricultural watersheds requires a comprehensive evaluation that takes into consideration important NMP attributes and location-specific farming conditions. This study applied the Soil and Water Assessment Tool (SWAT) to investigate the effects of crop and rotation sequence, tillage type, and nutrient N application rate on crop yield and the associated groundwater leaching and sediment loss. The SWAT model was applied to the Thomas Brook Watershed, located in the most intensively managed agricultural region of Nova Scotia, Canada. Cropping systems evaluated included seven fertilizer application rates and two tillage systems (i.e., conventional tillage and no-till). The analysis reflected cropping systems commonly managed by farmers in the Annapolis Valley region, including grain corn-based and potato-based cropping systems, and a vegetable-horticulture system. ANOVA models were developed and used to assess the effects of crop management choices on crop yield and two water-quality parameters (i.e., leaching and sediment loading). Results suggest that existing recommended N-fertilizer rate can be reduced by 10-25 %, for grain crop production, to significantly lower leaching ( P > 0.05) while optimizing the crop yield. The analysis identified the nutrient N rates in combination with specific crops and rotation systems that can be used to manage leaching while balancing impacts on crop yields within the watershed.

Graphene-Fiber-Based Supercapacitors Favor N-Methyl-2-pyrrolidone/Ethyl Acetate as the Spinning Solvent/Coagulant Combination.

PubMed

He, Nanfei; Pan, Qin; Liu, Yixin; Gao, Wei

2017-07-26

One-dimensional flexible fiber supercapacitors (FSCs) have attracted great interest as promising energy-storage units that can be seamlessly incorporated into textiles via weaving, knitting, or braiding. The major challenges in this field are to develop tougher and more efficient FSCs with a relatively easy and scalable process. Here, we demonstrate a wet-spinning process to produce graphene oxide (GO) fibers from GO dispersions in N-methyl-2-pyrrolidone (NMP), with ethyl acetate as the coagulant. Upon chemical reduction of GO, the resulting NMP-based reduced GO (rGO) fibers (rGO@NMP-Fs) are twice as high in the surface area and toughness but comparable in tensile strength and conductivity as that of the water-based rGO fibers (rGO@H 2 O-Fs). When assembled into parallel FSCs, rGO@NMP-F-based supercapacitors (rGO@NMP-FSCs) offered a specific capacitance of 196.7 F cm -3 (147.5 mF cm -2 ), five times higher than that of rGO@H 2 O-F-based supercapacitors (rGO@H 2 O-FSCs) and also higher than most existing wet-spun rGO-FSCs, as well as those FSCs built with metal wires, graphene/carbon nanotube (CNT) fibers, or even pseudocapacitive materials. In addition, our rGO@NMP-FSCs can provide good bending and cycling stability. The energy density of our rGO@NMP-FSCs reaches ca. 6.8 mWh cm -3 , comparable to that of a Li thin-film battery (4 V/500 μAh).

Changes in Sports Participation across Transition to Retirement: Modification by Migration Background and Acculturation Status.

PubMed

Schönbach, Johanna-Katharina; Pfinder, Manuela; Börnhorst, Claudia; Zeeb, Hajo; Brand, Tilman

2017-11-08

While total physical activity decreases over the life course, sports and leisure-time physical activity (LTPA) have shown to increase after transition to retirement. This paper aimed to investigate whether this change in sports participation differs (1) between non-migrant persons (NMP) versus persons with a migrant background (PMB), and (2) by acculturation status. Data was drawn from 16 waves of the German Socio-Economic Panel Study (SOEP) including 2664 NMP and 569 PMB. PMB were grouped according to acculturation status (integrated, assimilated, marginalised, separated), assessed regarding three dimensions (language, social interaction and identification). We applied multilevel logistic regression models, adjusting for sex, retirement age, socioeconomic status, health status and body mass index. Our results show that (1) transition to retirement led to an increase in the sports participation of NMP during the first 5 years and the subsequent 5 years after retirement. Changes in sports participation were modified by migration status: In PMB sports participation increased to a lesser extent than in NMP. (2) While sports participation of integrated PMB was not significantly different from NMP in the preretirement phase, sports participation among integrated PMB increased less after retirement compared with NMP. Marginalized and assimilated PMB did not show consistent sports participation patterns before retirement, but seemingly increased their sports participation less than NMP over the retirement transition. Separated PMB had particularly low levels of sports participation. Considering that LTPA is a key factor for healthy ageing, the increasing gap in levels of sports participation after transition to retirement indicates the need for interventions targeting physical activity of the older migrant population.

Clinical and cost-effectiveness of non-medical prescribing: A systematic review of randomised controlled trials

PubMed Central

Marriott, John; Graham-Clarke, Emma; Shirley, Debra; Rushton, Alison

2018-01-01

Objective To evaluate the clinical and cost-effectiveness of non-medical prescribing (NMP). Design Systematic review. Two reviewers independently completed searches, eligibility assessment and assessment of risk of bias. Data sources Pre-defined search terms/combinations were utilised to search electronic databases. In addition, hand searches of reference lists, key journals and grey literature were employed alongside consultation with authors/experts. Eligibility criteria for included studies Randomised controlled trials (RCTs) evaluating clinical or cost-effectiveness of NMP. Measurements reported on one or more outcome(s) of: pain, function, disability, health, social impact, patient-safety, costs-analysis, quality adjusted life years (QALYs), patient satisfaction, clinician perception of clinical and functional outcomes. Results Three RCTs from two countries were included (n = 932 participants) across primary and tertiary care settings. One RCT was assessed as low risk of bias, one as high risk of bias and one as unclear risk of bias. All RCTs evaluated clinical effectiveness with one also evaluating cost-effectiveness. Clinical effectiveness was evaluated using a range of safety and patient-reported outcome measures. Participants demonstrated significant improvement in outcomes when receiving NMP compared to treatment as usual (TAU) in all RCTs. An associated cost analysis showed NMP to be more expensive than TAU (regression coefficient p = 0.0000), however experimental groups generated increased QALYs compared to TAU. Conclusion Limited evidence with overall unclear risk of bias exists evaluating clinical and cost-effectiveness of NMP across all professions and clinical settings. GRADE assessment revealed moderate quality evidence. Evidence suggests that NMP is safe and can provide beneficial clinical outcomes. Benefits to the health economy remain unclear, with the cost-effectiveness of NMP assessed by a single pilot RCT of low risk of bias. Adequately powered low risk of bias RCTs evaluating clinical and cost effectiveness are required to evaluate NMP across clinical specialities, professions and settings. Registration PROSPERO (CRD42015017212). PMID:29509763

Leveraging the Educational Outreach Efforts of Low-Cost Missions

NASA Technical Reports Server (NTRS)

Fisher, Diane K.; Leon, Nancy J.

2000-01-01

A small portion of the budget for every NASA mission must be devoted to education and public outreach. The question is, how can projects best leverage these funds to create a high-quality message and get it disseminated to the largest and most appropriate audience? This paper describes the approach taken by a small educational outreach team for NASA's New Millennium Program (NMP). The team's approach has been twofold: develop a highly desirable suite of products designed to appeal to, as well as enlighten, the target audience; then negotiate relationships with existing, often under-utilized channels for dissemination of these products. Starting with NMP missions as the base of support for these efforts, the team has invited participation by other missions. This approach has resulted in a richer and broader message, and has allowed the continuing development of the audience base.

Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT).

PubMed

Alvarez, Marta B; Childress, Paul; Philip, Binu K; Gerard-O'Riley, Rita; Hanlon, Michael; Herbert, Brittney-Shea; Robling, Alexander G; Pavalko, Fredrick M; Bidwell, Joseph P

2012-05-01

Intermittent parathyroid hormone (PTH) adds new bone to the osteoporotic skeleton; the transcription factor Nmp4/CIZ represses PTH-induced bone formation in mice and as a consequence is a potential drug target for improving hormone clinical efficacy. To explore the impact of Nmp4/CIZ on osteoblast phenotype, we immortalized bone marrow stromal cells from wildtype (WT) and Nmp4-knockout (KO) mice using murine telomerase reverse transcriptase. Clonal lines were initially chosen based on their positive staining for alkaline phosphatase and capacity for mineralization. Disabling Nmp4/CIZ had no gross impact on osteoblast phenotype development. WT and KO clones exhibited identical sustained growth, reduced population doubling times, extended maintenance of the mature osteoblast phenotype, and competency for differentiating toward the osteoblast and adipocyte lineages. Additional screening of the immortalized cells for PTH-responsiveness permitted further studies with single WT and KO clones. We recently demonstrated that PTH-induced c-fos femoral mRNA expression is enhanced in Nmp4-KO mice and in the present study we observed that hormone stimulated either an equivalent or modestly enhanced increase in c-fos mRNA expression in both primary null and KO clone cells depending on PTH concentration. The null primary osteoblasts and KO clone cells exhibited a transiently enhanced response to bone morphogenetic protein 2 (BMP2). The clones exhibited lower and higher expressions of the PTH receptor (Pthr1) and the BMP2 receptor (Bmpr1a, Alk3), respectively, as compared to primary cells. These immortalized cell lines will provide a valuable tool for disentangling the complex functional roles underlying Nmp4/CIZ regulation of bone anabolism. Copyright © 2011 Wiley Periodicals, Inc.

Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors

PubMed Central

Kohler, Samay; Buck, Annika; Dambacher, Christine; König, Armin; Bohnert, Jürgen A.; Kern, Winfried V.

2014-01-01

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activity in various Gram-negative bacteria expressing AcrB, the major efflux pump of Escherichia coli, or similar homologous pumps of the resistance-nodulation-cell division class. The aim of the present study was to generate E. coli AcrB mutants resistant to the inhibitory action of the two model EPIs and to identify putative EPI target residues in order to better understand mechanisms of pump inhibition. Using an in vitro random mutagenesis approach focusing on the periplasmic domain of AcrB, we identified the double mutation G141D N282Y, which substantially compromised the synergistic activity of NMP with linezolid, was associated with similar intracellular linezolid concentrations in the presence and absence of NMP, and did not impair the intrinsic MICs of various pump substrates and dye accumulation. We propose that these mutations near the outer face of the distal substrate binding pocket reduce NMP trapping. Other residues found to be relevant for efflux inhibition by NMP were G288 and A279, but mutations at these sites also changed the susceptibility to several pump substrates. Unlike with NMP, we were unable to generate AcrB periplasmic domain mutants with resistance or partial resistance to the EPI activity of PAβN, which is consistent with the modes of action of PAβN differing from those of NMP. PMID:25182653

Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model

PubMed Central

Thoma, Daniel S.

2017-01-01

The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed. Bone formation in all groups was predominantly located close to the access window and the lateral walls. Newly formed bone within the total augmented area (NBTA) was greatest in BMP/NMP (1.94 ± 0.69 mm2), followed by BMP (1.50 ± 0.72 mm2) and BCP (1.28 ± 0.52 mm2) (P > 0.05). In the center of the augmentation (NBROI_C) and the area close to the sinus membrane (NBROI_M), BMP/NMP produced the largest area of NB (NBROI_C: 0.10 ± 0.11 mm2; NBROI_M: 0.17 ± 0.08 mm2); the corresponding NB values for BCP were 0.05 ± 0.05 mm2 and 0.08 ± 0.09 mm2, respectively (P > 0.05 for all comparisons). The effect of NMP on bone regeneration was inconsistent between the specimens. Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls. PMID:28680881

Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs.

PubMed

Jung, Ronald E; Kokovic, Vladimir; Jurisic, Milan; Yaman, Duygu; Subramani, Karthikeyan; Weber, Franz E

2011-08-01

The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied. In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM. The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended. © 2010 John Wiley & Sons A/S.

Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model.

PubMed

Lim, Hyun-Chang; Thoma, Daniel S; Yoon, So-Ra; Cha, Jae-Kook; Lee, Jung-Seok; Jung, Ui-Won

2017-01-01

The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed. Bone formation in all groups was predominantly located close to the access window and the lateral walls. Newly formed bone within the total augmented area (NB TA ) was greatest in BMP/NMP (1.94 ± 0.69 mm 2 ), followed by BMP (1.50 ± 0.72 mm 2 ) and BCP (1.28 ± 0.52 mm 2 ) ( P > 0.05). In the center of the augmentation (NB ROI_C ) and the area close to the sinus membrane (NB ROI_M ), BMP/NMP produced the largest area of NB (NB ROI_C : 0.10 ± 0.11 mm 2 ; NB ROI_M : 0.17 ± 0.08 mm 2 ); the corresponding NB values for BCP were 0.05 ± 0.05 mm 2 and 0.08 ± 0.09 mm 2 , respectively ( P > 0.05 for all comparisons). The effect of NMP on bone regeneration was inconsistent between the specimens. Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.

Changes in Sports Participation across Transition to Retirement: Modification by Migration Background and Acculturation Status

PubMed Central

Schönbach, Johanna-Katharina; Pfinder, Manuela; Börnhorst, Claudia; Zeeb, Hajo; Brand, Tilman

2017-01-01

While total physical activity decreases over the life course, sports and leisure-time physical activity (LTPA) have shown to increase after transition to retirement. This paper aimed to investigate whether this change in sports participation differs (1) between non-migrant persons (NMP) versus persons with a migrant background (PMB), and (2) by acculturation status. Data was drawn from 16 waves of the German Socio-Economic Panel Study (SOEP) including 2664 NMP and 569 PMB. PMB were grouped according to acculturation status (integrated, assimilated, marginalised, separated), assessed regarding three dimensions (language, social interaction and identification). We applied multilevel logistic regression models, adjusting for sex, retirement age, socioeconomic status, health status and body mass index. Our results show that (1) transition to retirement led to an increase in the sports participation of NMP during the first 5 years and the subsequent 5 years after retirement. Changes in sports participation were modified by migration status: In PMB sports participation increased to a lesser extent than in NMP. (2) While sports participation of integrated PMB was not significantly different from NMP in the preretirement phase, sports participation among integrated PMB increased less after retirement compared with NMP. Marginalized and assimilated PMB did not show consistent sports participation patterns before retirement, but seemingly increased their sports participation less than NMP over the retirement transition. Separated PMB had particularly low levels of sports participation. Considering that LTPA is a key factor for healthy ageing, the increasing gap in levels of sports participation after transition to retirement indicates the need for interventions targeting physical activity of the older migrant population. PMID:29117151

Paint Removers: Methylene Chloride and n-Methylpyrrolidone (NMP)

EPA Pesticide Factsheets

This webinar described the risks associated with NMP, provided an overview of TSCA section 6, and solicited input on ways EPA should address identified risks, with a particular emphasis on vulnerable populations.

Methodological assessment of the reduction of the content of impurities in nimodipine emulsion via the use of 21 amino acid protection

PubMed Central

Xie, Yiqiao; Zhuang, Zhiquan; Zhang, Shu; Xia, Zihua; Chen, De; Fan, Kaiyan; Ren, Jialin; Lin, CuiCui; Chen, Yanzhong; Yang, Fan

2017-01-01

Purpose The present study examined the factors affecting the content of impurities of nimodipine (NMP) emulsion and the associated methods of compound protection. Methods Destructive testing of NMP emulsion and its active pharmaceutical ingredient (API) were conducted, and ultracentrifugation was used to study the content of impurities in two phases. The impurity of NMP was measured under different potential of hydrogen (pH) conditions, antioxidants and pH-adjusting agents. Results Following destruction, the degradation of NMP notably occurred in the basic environment. The consumption of the pH-adjusting agent NaOH was proportional to the production of impurities since the inorganic base and/or acid promoted the degradation of NMP. The organic antioxidants, notably amino acids with an appropriate length of intermediate chain and electron-donating side group, exhibited improved antioxidant effects compared with inorganic antioxidants. The minimal amount of impurities was produced following addition of 0.04% lysine and 0.06% leucine in the aqueous phase and adjustment of the pH to a range of 7.5–8.0 in the presence of acetic acid solution. Conclusion NMP was more prone to degradation in an oxidative environment, in an aqueous phase and/or in the presence of inorganic pH-adjusting agents and antioxidants. The appropriate antioxidant and pH-adjusting agent should be selected according to the chemical structure, while destructive testing of the drug is considered to play the optimal protective effect. PMID:28490879

Technical and economic analysis of solvent-based lithium-ion electrode drying with water and NMP

DOE PAGES

Wood, David L.; Quass, Jeffrey D.; Li, Jianlin; ...

2017-05-16

Processing lithium-ion battery (LIB) electrode dispersions with water as the solvent during primary drying offers many advantages over N-methylpyrrolidone (NMP). An in-depth analysis of the comparative drying costs of LIB electrodes is discussed for both NMP- and water-based dispersion processing in terms of battery pack $/kWh. Electrode coating manufacturing and capital equipment cost savings are compared for water vs. conventional NMP organic solvent processing. A major finding of this work is that the total electrode manufacturing costs, whether water- or NMP-based, contribute about 8–9% of the total pack cost. However, it was found that up to a 2 × reductionmore » in electrode processing (drying and solvent recovery) cost can be expected along with a $3–6 M savings in associated plant capital equipment (for a plant producing 100,000 10-kWh Plug-in Hybrid Electric Vehicle (PHEV) batteries) using water as the electrode solvent. This paper shows a different perspective in that the most important benefits of aqueous electrode processing actually revolve around capital equipment savings and environmental stewardship and not processing cost savings.« less

Monitoring Floods with NASA's ST6 Autonomous Sciencecraft Experiment: Implications on Planetary Exploration

NASA Technical Reports Server (NTRS)

Ip, Felipe; Dohm, J. M.; Baker, V. R.; Castano, B.; Chien, S.; Cichy, B.; Davies, A. G.; Doggett, T.; Greeley, R.; Sherwood, R.

2005-01-01

NASA's New Millennium Program (NMP) Autonomous Sciencecraft Experiment (ASE) [1-3] has been successfully demonstrated in Earth-orbit. NASA has identified the development of an autonomously operating spacecraft as a necessity for an expanded program of missions exploring the Solar System. The versatile ASE spacecraft command and control, image formation, and science processing software was uploaded to the Earth Observer 1 (EO-1) spacecraft in early 2004 and has been undergoing onboard testing since May 2004 for the near real-time detection of surface modification related to transient geological and hydrological processes such as volcanism [4], ice formation and retreat [5], and flooding [6]. Space autonomy technology developed as part of ASE creates the new capability to autonomously detect, assess, react to, and monitor dynamic events such as flooding. Part of the challenge has been the difficulty to observe flooding in real time at sufficient temporal resolutions; more importantly, it is the large spatial extent of most drainage networks coupled with the size of the data sets necessary to be downlinked from satellites that make it difficult to monitor flooding from space. Below is a description of the algorithms (referred to as ASE Flood water Classifiers) used in tandem with the Hyperion spectrometer instrument on EO-1 to identify flooding and some of the test results.

Synthesis, crystal structures, quantum chemical studies and corrosion inhibition potentials of 4-(((4-ethylphenyl)imino)methyl)phenol and (E)-4-((naphthalen-2-ylimino) methyl) phenol Schiff bases

NASA Astrophysics Data System (ADS)

Elemike, Elias E.; Nwankwo, Henry U.; Onwudiwe, Damian C.; Hosten, Eric C.

2017-11-01

Two Schiff base ligands, 4-(((4-ethylphenyl)imino)methyl)phenol (4EMP) and (E)-4-((naphthalen-2-ylimino) methyl) phenol (4NMP) were synthesized by the reaction of 4-hydroxybenzaldehyde with 4-ethylaniline, 4EMP, or naphthalene-2-amine, 4NMP. The compounds were characterized using NMR (1H and 13C), Fourier transform infra-red (FTIR) and mass spectroscopic techniques. The proton NMR identified the OH peaks at 9.73 and 9.77 ppm for 4EMP and 4NMP respectively, while the 13C NMR showed the imine carbons at 172.57 ppm for 4EMP and at 160.89 ppm for 4NMP. The FTIR spectra showed characteristic peaks at 1605 cm-1 (4EMP) and 1600 cm-1 (4NMP) typical of the azomethine group, and the mass spectra results gave molecular ion peaks of 226.12 and 248.10 respectively. The structures of the compounds were further established by single crystal X-ray analysis. The corrosion inhibition potential of the compounds were studied on mild steel surface in a 1 M hydrochloric acid (HCl) solution, and was analysed using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). The results of the electrochemical methods showed that the studied molecules imparted high resistance in allowing flow of electrons across the metal-electrolyte platform and behaved as mixed type inhibitors with 4EMP showing better inhibition properties than 4NMP. Scanning electron microscopy (SEM) showed the formation of film on the mild steel surface. Quantum chemical calculations achieved by density functional theory (DFT) was further applied to explain the adsorption as well as inhibition abilities of the molecules on the mild steel surface. Thermodynamics studies showed that the two compounds obeyed the Langmuir isotherm with 4EMP conforming to chemisorption mechanism while 4NMP involved competitive physisorption and chemisorption mechanism.

Responses to Comments for N-Methylpyrrolidone (NMP) Work Plan Risk Assessment

EPA Pesticide Factsheets

This document summarizes the public and external peer review comments that the EPA’s Office of Pollution Prevention and Toxics (OPPT) received for the draft work plan risk assessment for n-Methylpyrrolidone (NMP).

Considerations for spectroscopy of liquid-exfoliated 2D materials: emerging photoluminescence of N-methyl-2-pyrrolidone.

PubMed

Ogilvie, Sean P; Large, Matthew J; Fratta, Giuseppe; Meloni, Manuela; Canton-Vitoria, Ruben; Tagmatarchis, Nikos; Massuyeau, Florian; Ewels, Christopher P; King, Alice A K; Dalton, Alan B

2017-12-01

N-methyl-2-pyrrolidone (NMP) has been shown to be the most effective solvent for liquid phase exfoliation and dispersion of a range of 2D materials including graphene, molybdenum disulphide (MoS 2 ) and black phosphorus. However, NMP is also known to be susceptible to sonochemical degradation during exfoliation. We report that this degradation gives rise to strong visible photoluminescence of NMP. Sonochemical modification is shown to influence exfoliation of layered materials in NMP and the optical absorbance of the solvent in the dispersion. The emerging optical properties of the degraded solvent present challenges for spectroscopy of nanomaterial dispersions; most notably the possibility of observing solvent photoluminescence in the spectra of 2D materials such as MoS 2 , highlighting the need for stable solvents and exfoliation processes to minimise the influence of solvent degradation on the properties of liquid-exfoliated 2D materials.

Accuracy Profiles for Analyzing Residual Solvents in Textiles by GC-MS.

PubMed

Bao, Qibei; Fu, Kejie; Ren, Qingqing; Zhong, Yingying; Qian, Dan

2017-10-01

Excess residual solvents (RSs) in clothes or other textiles could be toxic and pose risks to both humans and the environment. N,N-Dimethylformamide (DMF), N,N-dimethylacetamide (DMAc) and 1-methyl-2-pyrrolidinone (NMP) are important chemicals frequently used as solvents in the textile industry. Several organizations have proposed limiting DMF, DMAc and NMP in textiles, but an appropriate detection method has not been proposed. A sensitive GC-MS method for the quantification of DMF, DMAc and NMP in textiles was developed. After extraction with ethyl acetate, these RSs were separated on a DB-5MS capillary column. The oven temperature was increased from 50°C (held for 0.5 min) at 10°C/min to 120°C (held for 1 min). The method was fully validated according to the accuracy profile procedure, which is based on β-expectation tolerance intervals for the total measurement bias. Linearity was observed in the range of 0.5-10 mg/L for the solvents with limit of quantification values of 4.2, 3.5 and 2.5 mg/kg for DMF, DMAc and NMP, respectively. The repeatability and intermediate precision were <5.34% and 7.95% for DMF, 5.37% and 9.68% for DMAc, and 2.68% and 5.85% for NMP. The recoveries of DMF, DMAc and NMP were 91.2-106.3%, 89.5-97.7% and 85.6-101.3%, respectively. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Synthesis and polymorphic control for visible light active titania nanoparticles

NASA Astrophysics Data System (ADS)

Kaewgun, Sujaree

Titania (TiO2) is useful for many applications in photocatalysis, antimicrobials, pigment, deodorization, and decomposition of harmful organics and undesirable compounds in the air and waste water under UV irradiation. Among the three phases of TiO2, Rutile, Anatase, and Brookite, studies have been more focused on the anatase and rutile phases. Pure brookite is the most difficult phase to prepare, even under hydrothermal conditions. Predominantly brookite phase TiO2 nanoparticles were prepared by the Water-based Ambient Condition Sol (WACS) process in our laboratory. The objectives of this research were to enhance visible light active (VLA) photocatalytic properties of polymorphic brookite TiO2 by minimizing the lattice defects and narrowing band gap of titania by nitrogen and/or carbon chromophone, and to investigate the deactivation, reusability, and regeneration of the VLA titania in order to design better titania catalysts for organic compound degradation applications. In order to study the influence of hydroxyl content on photocatalytic activities (PCAs) of polymorphic titania nanoparticles, the WACS samples were post-treated by a Solvent-based Ambient Condition Sol (SACS) process in sec-butanol (sec-BuOH). All samples were characterized for phase composition, surface area, hydroxyl contamination, and particle morphology by x-ray diffraction, N2 physisorption, FT-IR, solid state 1H NMR and scanning electron microscopy, and then compared to a commercial titania, Degussa P25. Evaluation of methyl orange (MO) degradation under UV irradiation results showed that the lower lattice hydroxyl content in SACS titania enhanced the PCA. As-prepared titania and SACS samples, which have similar surface areas and crystallinity, were compared in order to prove that the superior PCA came from the reduction in the lattice hydroxyl content. To enhance PCA and VLA properties of WACS, an alternative high boiling point polar solvent, N-methylpyrrolidone (NMP), was utilized in the SACS process at a higher treatment temperature to modify polymorphic titania nanoparticles. This SACS sample was called "SACS-NMP". SACS, using NMP as the solvent, could also extract lattice hydroxyls, and decorate nitrogen on the titania surface. The PCA of SACS-NMP was superior to that of SACS-sec-BuOH. Nitrogen incorporation of SACS-NMP titania was investigated by CHN analysis and x-ray photoelectron spectroscopy (XPS). VL absorbance for all samples was characterized by UV-Vis absorption spectrophotometry. PCA of MO degradation under UV and VL showed that SACS-NMP is a powerful treatment to enhance PCA by minimizing lattice hydroxyls and doping the titania surface with nitrogen. The effect of calcination conditions on SACS-NMP samples was also studied. The calcination conditions, especially the temperature and calcination atmosphere, have an influence on the BET surface area, crystallite size, titania phase content, and PCA under VL irradiation. SACS-NMP samples calcined in air at 200°C for 2 hours showed the best VL activated photocatalytic performance in this research. Additionally, the SACS-NMP sample exhibited superior VL properties to several available reference anatase titania samples. This could be explained as the effective charge separation by the intercrystalline electron transport from brookite to anatase grains complemented by strong VL absorption by the nitrogen species in NMP. The deactivation and regeneration of the VLA titania were investigated and compared to a commercial titania, Kronos VLP7000. PCA of the titania under VL for MO decolorization gradually decreased with increasing testing time and the number of runs. The cause of the deactivation was identified as the deposition of the decomposed MO or the carbonaceous deposit. Among the possible regeneration procedures for used SACS-NMP samples, methanol washing was shown to be the most effective up to ˜80% of the PCA recovery. Accordingly, the SACS-NMP samples could not be completely recovered since a regeneration process would possibly remove some of nitrogen species responsible for the VL properties.

Direct determination of N-methyl-2-pyrrolidone metabolites in urine by HPLC-electrospray ionization-MS/MS using deuterium-labeled compounds as internal standard.

PubMed

Suzuki, Yoshihiro; Endo, Yoko; Ogawa, Masanori; Yamamoto, Shinobu; Takeuchi, Akito; Nakagawa, Tomoo; Onda, Nobuhiko

2009-11-01

N-methyl-2-pyrrolidone (NMP) has been used in many industries and biological monitoring of NMP exposure is preferred to atmospheric monitoring in occupational health. We developed an analytical method that did not include solid phase extraction (SPE) but utilized deuterium-labeled compounds as internal standard for high-performance liquid chromatography-electrospray ionization-mass spectrometry using a C30 column. Urinary concentrations of NMP and its known metabolites 5-hydoxy-N-methyl-2-pyrrolidone (5-HNMP), N-methyl-succinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) were determined in a single run. The method provided baseline separation of these compounds. Their limits of detection in 10-fold diluted urine were 0.0001, 0.006, 0.008, and 0.03 mg/L, respectively. Linear calibration covered a biological exposure index (BEI) for urinary concentration. The within-run and total precisions (CV, %) were 5.6% and 9.2% for NMP, 3.4% and 4.2% for 5-HNMP, 3.7% and 6.0% for MSI, and 6.5% and 6.9% for 2-HMSI. The method was evaluated using international external quality assessment samples, and urine samples from workers exposed to NMP in an occupational area.

Formation, expansion, and interconversion of metallarings in a sulfur-bridged Au(I) Co(III) coordination system.

PubMed

Oji, Katsuya; Igashira-Kamiyama, Asako; Yoshinari, Nobuto; Konno, Takumi

2014-02-10

A novel Au(I) Co(III) coordination system that is derived from the newly prepared [Co(D-nmp)2 ](-) (1(-) ; D-nmp=N-methyl-D-penicillaminate) and a gold(I) precursor Au(I) is reported. Complex 1(-) acts as a sulfur-donating metallaligand and reacts with the gold(I) precursor to give [Au2 Co2 (D-nmp)4 ] (2), which has an eight-membered Au(I) 2 Co(III) 2 metallaring. Treatment of 2 with [Au2 (dppe)2 ](2+) (dppe=1,2-bis(diphenylphosphino)ethane) leads to the formation of [Au4 Co2 (dppe)2 (D-nmp)4 ](2+) (3(2+) ), which consists of an 18-membered Au(I) 4 Co(III) 2 metallaring that accommodates a tetrahedral anion (BF4 (-) , ClO4 (-) , ReO4 (-) ). In solution, the metallaring structure of 3(2+) is readily interconvertible with the nine-membered Au(I) 2 Co(III) metallaring structure of [Au2 Co(dppe)(D-nmp)2 ](+) (4(+) ); this process depends on external factors, such as solvent, concentration, and nature of the counteranion. These results reveal the lability of the AuS and AuP bonds, which is essential for metallaring expansion and contraction. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Solid waste from aluminum recycling process: characterization and reuse of its economically valuable constituents.

PubMed

Shinzato, M C; Hypolito, R

2005-01-01

Due to economic advantages, many companies in Brazil recover Al from the process of crushing and water-leaching of secondary aluminum dross. Wastes from this process (non-metallic products and salts) are usually landfilled or disposed without treatment, causing many environmental damages. The purpose of this work is to investigate, in a recycling company sited in Sao Paulo metropolitan area (Brazil), the potential use of the non-metallic product (NMP) in the production of concrete blocks and to evaluate the presence of important chemical compounds that may be useful for other applications. Chemical and mineralogical analyses revealed that NMP is composed of refractory and abrasive oxides (alpha-Al2O3, MgAl2O4, SiO2) and an important source of transition alumina: alpha-Al(OH)3. Concrete blocks were made by adding two parts of NMP to one part of cement and four parts of sand. The blocks were tested according to the Brazilian standard (NBR7173/1982) and they passed dimension, humidity and absorption tests but not compressive strength tests. However, particular NMP constituents have accelerated the strength rate development of the blocks, thus decreasing working time. The commercial use of NMP can reduce the amount of discarded wastes contributing to environmental preservation.

Presence, distribution and molecular epidemiology of multi-drug-resistant Gram-negative bacilli from medical personnel of intensive care units in Tianjin, China, 2007-2015.

PubMed

Liu, H; Fei, C N; Zhang, Y; Liu, G W; Liu, J; Dong, J

2017-06-01

Multi-drug-resistant Gram-negative bacteria (MDRGNB) have become an important cause of nosocomial infection in intensive care units (ICUs). To investigate the molecular epidemiology of MDRGNB isolated from medical personnel (MP) and non-medical personnel (NMP) at 69 ICUs in Tianjin, China. From April 2007 to October 2015, 2636 nasal and hand swab samples from 1185 MP and 133 NMP were cultured for GNB (including MDRGNB), meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The susceptibilities of GNB to 14 antimicrobial agents were determined, and 80 MDRGNB were characterized using pulsed-field gel electrophoresis (PFGE) and dendrogram analysis. In total, 301 GNB were identified in 269 MP, including 109 MDRGNB isolates in 104 MP. Forty-two GNB were isolated from 39 NMP, which included 20 NMP with MDRGNB. Overall, 8.8% of MP were colonized with MDRGNB, which greatly exceeded colonization rates with MRSA (0.9%) and VRE (0.1%). Three pairs of Klebsiella pneumoniae and one pair of Enterobacter aerogenes were indistinguishable from each other, but the majority of isolate tests had distinct PFGE profiles. The prevalence of MDRGNB was high among ICU MP in Tianjin, and greatly exceeded that of VRE and MRSA. There was no difference in the rates of nasal carriage of MDRGNB between MP and NMP, but NMP were significantly more likely to have hand colonization with MDRGNB. PFGE profiles showed that there was only limited sharing of strains of MDR E. aerogenes and K. pneumoniae between personnel. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

SPE-GC/FTD determination of N-methyl-2-pyrrolidone and its metabolites in urine.

PubMed

Kubota, Ryuichi; Endo, Yoko; Takeuchi, Akito; Inoue, Yoshinori; Ogata, Hiroko; Ogawa, Masanori; Nakagawa, Tomoo; Onda, Nobuhiko; Endo, Ginji

2007-07-01

An analytical method using a combination of solid-phase extraction (SPE) and gas chromatography with a flame thermionic detector (GC/FTD) was developed for determination of N-methyl-2-pyrrolidone (NMP), N-methylsuccinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) in human urine. The SPE cartridge of poly(divinylbenzene/hydroxymethacrylate) used was directly loaded with urine sample, followed by elution with methyl isobutyl ketone (MIBK) and subsequent centrifugation, and the supernatant was injected into the capillary GC using a DB1701. This method allowed efficient separation of NMP, MSI, and 2-HMSI, which were nearly free of interference by other GC peaks arising from urine. Recoveries of NMP, MSI, and 2-HMSI from the SPE cartridge were about 98, 101, and 67%, respectively, with limits of detection of 0.04, 0.02, and 0.06 mg/L, respectively, which met the regulatory requirements. The present method was used for assay in biological monitoring of workers exposed to NMP in their occupational environment.

The Lunar Polesitter

NASA Technical Reports Server (NTRS)

West, John L.

2008-01-01

Here-to-fore, sailcraft mission and system studies have focused on sailcraft applications in support of NASA's science missions and, in a few studies, on the needs of other federal agencies such as the National Oceanic and Atmospheric Administration (NOAA) and Department of Defense (DoD). These studies have identified numerous promising applications for solar sails, leading NASA to support proposal efforts for three NASA New Millennium Program (NMP) flight demonstration opportunities (the Space Technology-5, -7, and -9 opportunities) as well as an extensive three-year ground development program in FY 2003-2005 sponsored by the NASA In-Space Propulsion Technology (ISPT) Program. What has not been done to date, however, is to investigate how the technology might also benefit the nation's (and NASA's) emerging interest in the Human Exploration Initiative (HEI). This paper reports on the first effort to address this shortfall in mission applications studies in support of HEI: the use of solar-sail-propelled Lunar Polesitter spacecraft which make use of the natural properties of the Earth-Moon L2 point and solar sail propulsion to enable their positioning near the Lunar poles to serve as communications relay stations. Suitably positioned, such spacecraft enable continuous communications to and from the Earth from any point on the lunar far side. The paper shows that a viable sailcraft system design exists permitting station-keeping of a Lunar Polesitter relay station at 40 Lunar radii from the Moon in the anti-Earth direction, displaced 6-8 Lunar radii below the Earth- Moon plane.

High T(g) Polyimides

NASA Technical Reports Server (NTRS)

Chuang, Kathy

2001-01-01

The use of high temperature polymer matrix composites in aerospace applications has expanded steadily over the past 30 years, due to the increasing demand of replacing metal parts with light weight composite materials for fuel efficiency and bigger payloads in the aircraft and the space transportation vehicles. Polyimide/carbon fiber composites, especially, have been regarded as major high temperature matrix materials, based on their outstanding performance in terms of heat resistance, high strength-to-weight ratio and property retention compared with epoxies (177 C/350 F) and bismaleimides (232 C/450 F). Traditional, then-neoplastic polyimides were prepared from dianhydrides and diamines in N-methyl-2-pyrrolidinone (NMP) at room temperature to form the polyamic acids, which were then imidized at 150 C to yield polyimides. However, the high-boiling solvent (NMP, BP= 202 C) is very difficult to remove, leading to the formation of voids during composite fabrication. In the early 1970's, PMR addition curing polyimides with reactive endcaps were developed at the Lewis Research Center (renamed NASA Glenn) to ensure the easy processing of imide oligomers in methanol during composite fabrication.

C60 Cheese Sticks: Supramolecular Architecture of an Amphiphilic Fullerene Pentapod.

PubMed

Samal, Monica; Acharya, Sandhyarani; Yi, Dong Kee; Lee, Jae-Suk; Samal, Shashadhar

2015-09-01

An amphiphillic fullerene pentaphenol derivative, C60(4-HOC6H4)5H, in an aprotic solvent N-methyl-2-pyrrolidone (NMP), spontaneously self-assembles to a hitherto unknown cheese stick-like (CS) structure. This fascinating structure is observed only for C60(4-HOC6H4)5H and only in dry NMP solvent. The reason for such unique self-assembly behavior is ascribed to solvating power typical of NMP. The CS structure is observed in a narrow concentration range of the solution. This indicates that there exists between the solute and the solvent an optimal interaction condition for CS to remain stable.

Perioperative haemostatic management of haemophilic mice using normal mouse plasma.

PubMed

Tatsumi, K; Ohashi, K; Kanegae, K; Shim, I K; Okano, T

2013-11-01

Intense haemostatic interventions are required to avoid bleeding complications when surgical procedures are performed on haemophilia patients. The objective of this study was to establish an appropriate protocol for perioperative haemostatic management of haemophilic mice. We assessed the prophylactic haemostatic effects of normal mouse plasma (NMP) on haemophilia B (HB) mice for both a skin flap procedure and a laparotomy. When 500 μL of NMP was administered to the mice, plasma factor IX (FIX:C) levels peaked at 15.1% immediately after intravenous (IV) administration, at 6.1% 2 h after intraperitoneal (IP) administration and at 2.7% 6 h after subcutaneous administration. Administering 500 μL of NMP via IP or IV 30 min in advance enabled the skin flap procedure to be performed safely without any complications. After the laparotomy procedure, several mice in the IP administration group exhibited lethal bleeding, but all mice survived in the IV administration group. Anti-mouse FIX inhibitors did not develop, even after repetitive administrations of NMP. However, human FIX concentrates, especially plasma-derived concentrates, elicited the anti-human FIX inhibitors. The results show that administering 500 μL of NMP via IV or IP 30 min in advance enables surgical procedures to be safely performed on HB mice, and that IV administration is more desirable than IP if the procedure requires opening of the abdominal wall. © 2013 John Wiley & Sons Ltd.

Updated Heliostorm Warning Mission: Enhancements Based on New Technology

NASA Technical Reports Server (NTRS)

Young, Roy M.

2007-01-01

The Heliostorm (also referred to as Geostorm) mission has been regarded as the best choice for the first application of solar sail technology. The objective of Heliostorm is to obtain data from an orbit station slightly displaced from the ecliptic at or nearer to the Sun than 0.98 AU, which places it twice as close to the sun as Earth's natural L1 point at 0.993 AU. The maintenance of such an orbit location would require prohibitive amounts of propellants using chemical or electric propulsion systems; however, a solar sailcraft is ideally suited for this purpose because it relies solely on the propulsive force from photons for orbit maintenance. Heliostorm has been the subject of several mission studies over the past decade, with the most complete study conducted in 1999 in conjunction with a proposed New Millennium Program (NMP) Space Technology 5 (ST-5) flight opportunity. Recently, over a two and one-half year period dating from 2003 through 2005, NASA's In-Space Propulsion Technology Program (ISTP) matured solar sail technology from laboratory components to full systems, demonstrated in as relevant a space environment as could feasibly be simulated on the ground. Work under this program has yielded promising results for enhanced Heliostorm mission performance. This enhanced performance is achievable principally through reductions in the sail areal density. These reductions are realized through the use of lower linear mass density booms, a thinner sail membrane, and increased sail area. Advancements in sailcraft vehicle system design also offer potential mass reductions and hence improved performance. This paper will present the preliminary results of an updated Heliostorm mission design study including the enhancements incorporated during the design, development, analysis and testing of the system ground demonstrator.

Updated Heliostorm Warning Mission: Enhancements Based on New Technology

NASA Technical Reports Server (NTRS)

Young, Roy M.

2007-01-01

The Heliostorm (also referred to as Geostorm) mission has been regarded as the best choice for the first application of solar sail technology. The objective of Heliostorm is to obtain data from an orbit station slightly displaced from the ecliptic at or nearer to the Sun than 0.98 AU, which places it twice as dose to the sun as Earth's natural L1 point at 0.993 AU. The maintenance of such an orbit location would require prohibitive amounts of propellants using chemical or electric propulsion systems; however, a solar sailcraft is ideally suited for this purpose because it relies solely on the propulsive force from photons for orbit maintenance. Heliostorm has been the subject of several mission studies over the past decade, with the most complete study conducted in 1999 in conjunction with a proposed New Millennium Program (NMP) Space Technology 5 (ST-5) flight opportunity. Recently, over a two and one-half year period dating from 2003 through 2005, NASA's In-Space Propulsion Technology Program (ISTP) matured solar sail technology from laboratory components to full systems, demonstrated in as relevant a space environment as could feasibly be simulated on the ground. Work under this program has yielded promising results for enhanced Heliostorm mission performance. This enhanced performance is achievable principally through reductions in the sail areal density. These reductions are realized through the use of lower linear mass density booms, a thinner sail membrane, and increased sail area. Advancements in sailcraft vehicle system design also offer potential mass reductions and hence improved performance. This paper will present the preliminary results of an updated Heliostorm mission design study including the enhancements incorporated during the design, development, analysis and testing of the system ground demonstrator.

Role of N-methyl-2-pyrrolidone for preparation of Fe3O4@SiO2 controlled the shell thickness

NASA Astrophysics Data System (ADS)

Wee, Sung-Bok; Oh, Hyeon-Cheol; Kim, Tae-Gyun; An, Gye-Seok; Choi, Sung-Churl

2017-04-01

We developed a simple and novel approach for the synthesis of Fe3O4@SiO2 nanoparticles with controlled shell thickness, and studied the mechanism. The introduction of N-methyl-2-pyrrolidone (NMP) led to trapping of monomer nuclei in single shell and controlled the shell thickness. Fe3O4@SiO2 controlled the shell thickness, showing a high magnetization value (64.47 emu/g). Our results reveal the role and change in the chemical structure of NMP during the core-shell synthesis process. NMP decomposed to 4-aminobutanoic acid in alkaline condition and decreased the hydrolysis rate of the silica coating process.

DEMONSTRATION OF N-METHYL PYRROLIDONE (NMP) AS A POLLUTION PREVENTION ALTERNATIVE TO PAINT STRIPPING WITH METHYLENE CHLORIDE

EPA Science Inventory

This objective of this paper is to demonstrate that NMP is a viable pollution prevention alternative to methylene chloride. Maine Corps Logistics Base (MCLB), Albany, GA, USA was the host site for the demonstration. MCLB's primary function is maintenance of military ground supp...

Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone

PubMed Central

Songkram, Chalermkiat

2016-01-01

Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid (MPA) which can be metabolized by esterase. MMF has been approved by the United States Food and Drug Administration (USFDA) for treatment of psoriasis patient with skin symptoms. However, it remains unclear whether MMF is efficiently effective to treat skin symptoms developed from psoriasis. The insufficient amount of MMF penetrating through the skin results in the treatment failure due to the difficulty in MMF penetration through the stratum corneum. Skin permeation enhancers such as eucalyptol (EUL) and N-methyl-2-pyrrolidone (NMP) potentially aid in increasing skin penetration. This study aimed to investigate the effects of a concentration ratio (% w/v) between two enhancers (EUL and NMP). The results showed that EUL enhanced MMF permeation with an enhancement ratio (ER) of 3.44 while NMP was not able to promote the penetration of MMF. Interestingly, the synergistic effect of the two enhancers was observed with a suitable ratio given that the ER was 8.21. EUL and NMP are promising enhancers for the development of MMF based skin product. PMID:27069715

Dynamic coupling between the LID and NMP domain motions in the catalytic conversion of ATP and AMP to ADP by adenylate kinase

NASA Astrophysics Data System (ADS)

Jana, Biman; Adkar, Bharat V.; Biswas, Rajib; Bagchi, Biman

2011-01-01

The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. We discover and analyze an interesting dynamical coupling between the motion of the two domains during the opening, using large scale atomistic molecular dynamics trajectory analysis, covariance analysis, and multidimensional free energy calculations with explicit water. Initially, the LID domain must open by a certain amount before the NMP domain can begin to open. Dynamical correlation map shows interesting cross-peak between LID and NMP domain which suggests the presence of correlated motion between them. This is also reflected in our calculated two-dimensional free energy surface contour diagram which has an interesting elliptic shape, revealing a strong correlation between the opening of the LID domain and that of the NMP domain. Our free energy surface of the LID domain motion is rugged due to interaction with water and the signature of ruggedness is evident in the observed root mean square deviation variation and its fluctuation time correlation functions. We develop a correlated dynamical disorder-type theoretical model to explain the observed dynamic coupling between the motion of the two domains in ADK. Our model correctly reproduces several features of the cross-correlation observed in simulations.

Extracellular Vesicles from Human Liver Stem Cells Reduce Injury in an Ex Vivo Normothermic Hypoxic Rat Liver Perfusion Model.

PubMed

Rigo, Federica; De Stefano, Nicola; Navarro-Tableros, Victor; David, Ezio; Rizza, Giorgia; Catalano, Giorgia; Gilbo, Nicholas; Maione, Francesca; Gonella, Federica; Roggio, Dorotea; Martini, Silvia; Patrono, Damiano; Salizzoni, Mauro; Camussi, Giovanni; Romagnoli, Renato

2018-05-01

The gold standard for organ preservation before transplantation is static cold storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury. An emerging alternative is normothermic machine perfusion (NMP), which permits organ reconditioning. Here, we aimed to explore the feasibility of a pharmacological intervention on isolated rat livers by using a combination of NMP and human liver stem cells-derived extracellular vesicles (HLSC-EV). We established an ex vivo murine model of NMP capable to maintain liver function despite an ongoing hypoxic injury induced by hemodilution. Livers were perfused for 4 hours without (control group, n = 10) or with HLSC-EV (treated group, n = 9). Bile production was quantified; perfusate samples were collected hourly to measure metabolic (pH, pO2, pCO2) and cytolysis parameters (AST, alanine aminotransferase, lactate dehydrogenase). At the end of perfusion, we assessed HLSC-EV engraftment by immunofluorescence, tissue injury by histology, apoptosis by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, tissue hypoxia-inducible factor 1-α, and transforming growth factor-beta 1 RNA expression by quantitative reverse transcription-polymerase chain reaction. During hypoxic NMP, livers were able to maintain homeostasis and produce bile. In the treated group, AST (P = 0.018) and lactate dehydrogenase (P = 0.032) levels were significantly lower than those of the control group at 3 hours of perfusion, and AST levels persisted lower at 4 hours (P = 0.003). By the end of NMP, HLSC-EV had been uptaken by hepatocytes, and EV treatment significantly reduced histological damage (P = 0.030), apoptosis (P = 0.049), and RNA overexpression of hypoxia-inducible factor 1-α (P < 0.0001) and transforming growth factor-beta 1 (P = 0.014). HLSC-EV treatment, even in a short-duration model, was feasible and effectively reduced liver injury during hypoxic NMP.

Folding Properties of Cytosine Monophosphate Kinase from E. coli Indicate Stabilization through an Additional Insert in the NMP Binding Domain

PubMed Central

Beitlich, Thorsten; Lorenz, Thorsten; Reinstein, Jochen

2013-01-01

The globular 25 kDa protein cytosine monophosphate kinase (CMPK, EC ID: 2.7.4.14) from E. coli belongs to the family of nucleoside monophosphate (NMP) kinases (NMPK). Many proteins of this family share medium to high sequence and high structure similarity including the frequently found α/β topology. A unique feature of CMPK in the family of NMPKs is the positioning of a single cis-proline residue in the CORE-domain (cis-Pro124) in conjunction with a large insert in the NMP binding domain. This insert is not found in other well studied NMPKs such as AMPK or UMP/CMPK. We have analyzed the folding pathway of CMPK using time resolved tryptophan and FRET fluorescence as well as CD. Our results indicate that unfolding at high urea concentrations is governed by a single process, whereas refolding in low urea concentrations follows at least a three step process which we interpret as follows: Pro124 in the CORE-domain is in cis in the native state (Nc) and equilibrates with its trans-isomer in the unfolded state (Uc - Ut). Under refolding conditions, at least the Ut species and possibly also the Uc species undergo a fast initial collapse to form intermediates with significant amount of secondary structure, from which the trans-Pro124 fraction folds to the native state with a 100-fold lower rate constant than the cis-Pro124 species. CMPK thus differs from homologous NMP kinases like UMP/CMP kinase or AMP kinase, where folding intermediates show much lower content of secondary structure. Importantly also unfolding is up to 100-fold faster compared to CMPK. We therefore propose that the stabilizing effect of the long NMP-domain insert in conjunction with a subtle twist in the positioning of a single cis-Pro residue allows for substantial stabilization compared to other NMP kinases with α/β topology. PMID:24205218

Biomonitoring of exposure to N-methyl-2-pyrrolidone in workers of the automobile industry.

PubMed

Meier, Swetlana; Schindler, Birgit K; Koslitz, Stephan; Koch, Holger M; Weiss, Tobias; Käfferlein, Heiko U; Brüning, Thomas

2013-07-01

N-methyl-2-pyrrolidone (NMP) is an important organic solvent for varnishes in industry. NMP has been previously shown to be a developmental toxicant in rodents. This study reports current exposures to NMP in the spraying department of an automobile plant using biological monitoring. Two specific metabolites, 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methyl-succinimide (2-HMSI), were analyzed in 69 urine samples of 14 workers exposed to NMP and 9 nonexposed controls. Three different working tasks ('loading' and 'cleaning' of the sprayer system and 'wiping/packing' of the sprayed materials) and three sampling times (preshift, postshift, and preshift of the following day) were studied in exposed workers. Median exposures of 5-HNMP and 2-HMSI in postshift urine of exposed workers were 0.91 and 0.52mg g(-1) creatinine, respectively, whereas median levels in controls were below the limit of detection. Decreased levels of 5-HNMP were observed in preshift urine samples on the following day (0.39mg g(-1) creatinine) in exposed workers, while the concentration of 2-HMSI did not change (0.49mg g(-1) creatinine). Highest exposures occurred during sprayer cleaning with a maximum level of 8.31mg g(-1) creatinine of 5-HNMP in postshift urine. In contrast to 'wipers/packers', no decrease in 5-HNMP could be observed in preshift urine samples on day 2 of the 'loaders' and 'cleaners'. Overall, exposure in terms of 5-HNMP postshift and 2-HMSI preshift of the following day were well below the current biological limit values of the European Union (70 and 20mg g(-1) creatinine). Our results provide initial data on NMP exposure in the automobile industry and suggest that the analysis of 5-HNMP in preshift samples also provides essential information, particularly in situations involving direct handling of liquid NMP-containing formulations.

Non-medical prescribing of chemotherapy: engaging stakeholders to maximise success?

PubMed

Lennan, Elaine

2014-01-01

This study report examines the views and experiences of professional stakeholders about non-medical prescribing (NMP) of chemotherapy. The introduction of open formulary NMP has created opportunities to radically change health-care delivery. For chemotherapy services, the most recent advice from the National Chemotherapy Advisory Group [Department of Health (2009) Chemotherapy Services in England, ensuring quality and safety: a report from the National Chemotherapy Advisory Group, London Her Majesty's Stationary Office] clearly endorses the development of nurse- or pharmacist-led chemotherapy clinics. This is very much welcomed but is based on very limited evidence as to their effectiveness. A fourth-generation evaluation study. A purposeful sample of 23 stakeholders connected with the chemotherapy service was used. A serial data collection technique with individual interviews followed by uni-professional focus groups was adopted. Finally, a multi-professional focus group was held to determine the strategic way forward. Data were collected in 2009-2010. The study illuminated the key features necessary to maximise success of NMP in chemotherapy clinics and captures the importance of good working relationships. Whilst different practice models will emerge, fundamental and core to services is the need for good team working, established and effective communication strategies, and most importantly avoiding isolation in practice. This study additionally reinforced any evaluation takes place within preexisting political contexts and in particular medical dominance. Not all medical colleagues agreed with or wanted NMP for their patients, highlighting difficulties of developing new models of working within a resisting culture. No objections to NMP of chemotherapy were found, but, clearly, the context of practice needs to be agreed and supportedby all professional stakeholders. What is already known about this topicOpen formulary non-medical prescribing has been rapidly introduced over the past decade.Little research has been conducted in acute care and none in the chemotherapy setting.Cancer policy recommends the introduction of nurse-led chemotherapy clinics.What this paper addsNon-medical prescribing (NMP) in chemotherapy is appropriate with the right model of practice.Well-established professional relationships are a key to success.NMP is not appropriate in isolation of the multidisciplinary team (MDT).Implications for practice and/or policyNurses need to demonstrate the value of non-medical prescribing in chemotherapy using available metrics.Models of practice need to ensure good communication channels, MDT working, and transparency of prescribing.

NASA's Autonomous Formation Flying Technology Demonstration, Earth Observing-1(EO-1)

NASA Technical Reports Server (NTRS)

Folta, David; Bristow, John; Hawkins, Albin; Dell, Greg

2002-01-01

NASA's first autonomous formation flying mission, the New Millennium Program's (NMP) Earth Observing-1 (EO-1) spacecraft, recently completed its principal goal of demonstrating advanced formation control technology. This paper provides an overview of the evolution of an onboard system that was developed originally as a ground mission planning and operations tool. We discuss the Goddard Space Flight Center s formation flying algorithm, the onboard flight design and its implementation, the interface and functionality of the onboard system, and the implementation of a Kalman filter based GPS data smoother. A number of safeguards that allow the incremental phasing in of autonomy and alleviate the potential for mission-impacting anomalies from the on- board autonomous system are discussed. A comparison of the maneuvers planned onboard using the EO-1 autonomous control system to those from the operational ground-based maneuver planning system is presented to quantify our success. The maneuvers discussed encompass reactionary and routine formation maintenance. Definitive orbital data is presented that verifies all formation flying requirements.

Integration of Libration Point Orbit Dynamics into a Universal 3-D Autonomous Formation Flying Algorithm

NASA Technical Reports Server (NTRS)

Folta, David; Bauer, Frank H. (Technical Monitor)

2001-01-01

The autonomous formation flying control algorithm developed by the Goddard Space Flight Center (GSFC) for the New Millennium Program (NMP) Earth Observing-1 (EO-1) mission is investigated for applicability to libration point orbit formations. In the EO-1 formation-flying algorithm, control is accomplished via linearization about a reference transfer orbit with a state transition matrix (STM) computed from state inputs. The effect of libration point orbit dynamics on this algorithm architecture is explored via computation of STMs using the flight proven code, a monodromy matrix developed from a N-body model of a libration orbit, and a standard STM developed from the gravitational and coriolis effects as measured at the libration point. A comparison of formation flying Delta-Vs calculated from these methods is made to a standard linear quadratic regulator (LQR) method. The universal 3-D approach is optimal in the sense that it can be accommodated as an open-loop or closed-loop control using only state information.

Autonomous Science Analysis with the New Millennium Program-Autonomous Sciencecraft Experiment

NASA Astrophysics Data System (ADS)

Doggett, T.; Davies, A. G.; Castano, R. A.; Baker, V. R.; Dohm, J. M.; Greeley, R.; Williams, K. K.; Chien, S.; Sherwood, R.

2002-12-01

The NASA New Millennium Program (NMP) is a testbed for new, high-risk technologies, including new software and hardware. The Autonomous Sciencecraft Experiment (ASE) will fly on the Air Force Research Laboratory TechSat-21 mission in 2006 is such a NMP mission, and is managed by the Jet Propulsion Laboratory, California Institute of Technology. TechSat-21 consists of three satellites, each equipped with X-band Synthetic Aperture Radar (SAR) that will occupy a 13-day repeat track Earth orbit. The main science objectives of ASE are to demonstrate that process-related change detection and feature identification can be conducted autonomously during space flight, leading to autonomous onboard retargeting of the spacecraft. This mission will observe transient geological and environmental processes using SAR. Examples of geologic processes that may be observed and investigated include active volcanism, the movement of sand dunes and transient features in desert environments, water flooding, and the formation and break-up of lake ice. Science software onboard the spacecraft will allow autonomous processing and formation of SAR images and extraction of scientific information. The subsequent analyses, performed on images formed onboard from the SAR data, will include feature identification using scalable feature "templates" for each target, change detection through comparison of current and archived images, and science discovery, a search for other features of interest in each image. This approach results in obtaining the same science return for a reduced amount of resource use (such as downlink) when compared to that from a mission operating without ASE technology. Redundant data is discarded. The science-driven goals of ASE will evolve during the ASE mission through onboard replanning software that can re-task satellite operations. If necessary, as a result of a discovery made autonomously by onboard science processing, existing observation sequences will be pre-empted to obtain data of potential high scientific content. Flight validation of this software will enable radically different missions with significant onboard decision-making and novel science concepts (onboard decision making and selective data return). This work has been carried out at the Jet Propulsion Laboratory-California Institute of Technology, under contract to NASA.

Combined use of epithelial membrane antigen and nuclear matrix protein 52 as sensitive biomarkers for detection of bladder cancer.

PubMed

Attallah, Abdelfattah M; El-Far, Mohamed; Abdallah, Sanaa O; El-Waseef, Ahmed M; Omran, Mohamed M; Abdelrazek, Mohamed A; Attallah, Ahmed A; Saadh, Mohamed J; Radwan, Mohamed; El-waffaey, Kholoud A; Abol-Enei, Hassan

2015-11-11

The advent of noninvasive urine-based markers as well as other novel modalities has yielded improved diagnostic accuracy. However, the new markers failed to reach higher sensitivity and specificity. We therefore evaluated the potential role of epithelial membrane antigen (EMA) and nuclear matrix protein 52 (NMP-52) singly and combined as noninvasive biomarkers for the detection of bladder cancer (BC). A total of 160 individuals including 66 patients with BC, 54 patients with benign urologic disorders and 40 healthy volunteers were investigated. Urinary EMA at 130 kDa and NMP at 52 kDa were identified, purified and quantified by Western blot, electroelution and enzyme-linked immunosorbent assay (ELISA). The diagnostic performance of each biomarker and their combination were compared using area under receiver operating characteristic curves (AUC). Mean urinary EMA, 2.42 µg/mL, and NMP-52, 17.85 µg/mL, were significantly elevated in patients with BC compared to controls, 1.18 and 3.44 µg/mL, respectively (p<0.0001). The combined use of these markers yielded values which were increased 4.4- and 13.7-fold in the benign and malignant disease groups, respectively, with respect to the normal group. The values of EMA and NMP-52 were significantly higher in patients with higher-grade tumors than those with lower-grade tumors (p<0.0001). Moreover, this combination could predict all BC stages and grades with 0.91 AUC, 94% sensitivity and 80% specificity. EMA and NMP-52 in combination could be promising noninvasive biomarkers for BC detection.

Nomophobic behaviors among smartphone using medical and engineering students in two colleges of West Bengal.

PubMed

Dasgupta, Pallabi; Bhattacherjee, Sharmistha; Dasgupta, Samir; Roy, Jayanta Kumar; Mukherjee, Abhijit; Biswas, Romy

2017-01-01

Growing smartphone usage among global and Indian college students has resulted in considerable issues of "nomophobia" (NMP) or feelings of discomfort or anxiety experienced by individuals whenever unable to use their smartphones. This significantly impacts their health, work, and study. The objective of this study is to find out the prevalence of NMP among smartphone using medical and engineering undergraduates of West Bengal and to compare the nomophobic behaviors, its predictors, and smartphone usage among them. A cross-sectional study was conducted among 303 medical and 305 engineering undergraduates in West Bengal using a validated NMP questionnaire consisting of four factors. Comparison of means of individual questions and factor scores was done. Nomophobic clusters among the two groups were identified using two-stage cluster analysis. Binary logistic regression was used for comparison of predictors of NMP. Engineering students showed a higher proportion of nomophobics (44.6%) than medical students (42.6%). Significant higher means was observed among engineering students for the factor "giving upconvenience" and individual variables like "scared due to running out of battery," "nervous due to disconnection from online identity," "uncomfortable when unable stay up-to-date with social media" and "anxious when unable to check E-mails." A Higher proportion of nomophobics among both groups were females, those owning smartphone beyond 2 years, having monthly mobile bill above Rs. 200 and spending over 4 h daily on smartphone. NMP has emerged as a significant cause of concern among both the groups. Standardized measures for identification and appropriate psychobehavioral therapy for those seeking help might alleviate the problem.

Investigation on the relationship between solubility of artemisinin and polyvinylpyrroli done addition by using DAOSD approach

NASA Astrophysics Data System (ADS)

Zhang, Jin; Guo, Ran; He, Anqi; Weng, Shifu; Gao, Xiuxiang; Xu, Yizhuang; Noda, Isao; Wu, Jinguang

2017-07-01

In this work, we investigated the influence of polyvinylpyrrolidone (PVP) on the solubility of artemisinin in aqueous solution by using quantitative 1H NMR. Experimental results demonstrate that about 4 times of incremental increase occurs on the solubility of artemisinin upon introducing PVP. In addition, dipole-dipole interaction between the ester group of artemisinin and the amide group of N-methylpyrrolidone (NMP), a model compound of PVP, is characterized by two-dimensional (2D) correlation FTIR spectroscopy with the DAOSD (Double Asynchronous Orthogonal Sample Design) approach developed in our previous work. The observation of cross peaks in a pair of 2D asynchronous spectra suggests that dipole-dipole interaction indeed occurs between the ester group of artemisinin and amide group of NMP. Moreover, the pattern of cross peaks indicates that the carbonyl band of artemisinin undergoes blue-shift while the bandwidth and absorptivity increases via interaction with NMP, and the amide band of NMP undergoes blue-shift while the absorptivity increases via interaction with artemisinin. Dipole-dipole interaction, as one of the strongest intermolecular interaction between artemisinin and excipient, may play an important role in the enhancement of the solubility of artemisinin in aqueous solution.

Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flick, Burkhard; Talsness, Chris E.; Jaeckh, Rudolf

2009-06-01

N-methyl-2-pyrrolidone (NMP), which undergoes extensive biotransformation, has been shown in vivo to cause developmental toxicity and, especially after oral treatment, malformations in rats and rabbits. Data are lacking as to whether the original compound or one of its main metabolites is responsible for the toxic effects observed. Therefore, the relative embryotoxicity of the parent compound and its metabolites was evaluated using rat whole embryo culture (WEC) and the balb/c 3T3 cytotoxicity test. The resulting data were evaluated using two strategies; namely, one based on using all endpoints determined in the WEC and the other including endpoints from both the WECmore » and the cytotoxicity test. On basis of the first analysis, the substance with the highest embryotoxic potential is NMP, followed by 5-hydroxy-N-methyl-pyrrolidone (5-HNMP), 2-hydroxy-N-methylsuccinimide (2-HMSI) and N-methylsuccinimide (MSI). Specific dysmorphogeneses induced by NMP and 5-HNMP were aberrations in the head region of the embryos, abnormal development of the second visceral arches and open neural pores. The second evaluation strategy used only two endpoints of the WEC, i.e. the no observed adverse effect concentration (NOAEC{sub WEC}) and the lowest concentration leading to dysmorphogenesis in 100% of the cultured embryos (IC{sub MaxWEC}). In addition to these WEC endpoints the IC{sub 503T3} from the cytotoxicity test (balb/c 3T3 fibroblasts) was included in the evaluation scheme. These three endpoints were applied to a prediction model developed during a validation study of the European Centre for the Validation of Alternative Methods (ECVAM) allowing the classification of the embryotoxic potential of each compound into three classes (non-, weakly- and strongly embryotoxic). Consistent results from both evaluation strategies were observed, whereby NMP and its metabolites revealed a direct embryotoxic potential. Hereby, only NMP and 5-HNMP induced specific embryotoxic effects and were classified as weakly embryotoxic, whereas the other two metabolites, 2-HMSI and MSI, were determined to be non-embryotoxic.« less

National medicines policies – a review of the evolution and development processes

PubMed Central

2013-01-01

Objectives Continuous provision of appropriate medicines of assured quality, in adequate quantities, and at reasonable prices is a concern for all national governments. A national medicines policy (NMP) developed in a collaborative fashion identifies strategies needed to meet these objectives and provides a comprehensive framework to develop all components of a national pharmaceutical sector. To meet the health needs of the population, there is a general need for medicine policies based on universal principles, but nevertheless adapted to the national situation. This review aims to provide a quantitative and qualitative (describing the historical development) study of the development process and evolution of NMPs. Methods The number of NMPs and their current status has been obtained from the results of the assessment of WHO Level I indicators. The policy formulation process is examined in more detail with case studies from four countries: Sri Lanka, Australia, former Yugoslav Republic of Macedonia and South Africa. Results The number of NMPs worldwide has increased in the last 25 years with the highest proportional increase in the last 5–10 years in high-income countries. Higher income countries seem to have more NMP implementation plans available and have updated their NMP more recently. The four case studies show that the development of a NMP is a complex process that is country specific. In addition, it demonstrates that an appropriate political window is needed for the policy to be passed (for South Africa and the FYR Macedonia, a major political event acted as a trigger for initiating the policy development). Policy-making does not stop with the official adoption of a policy but should create mechanisms for implementation and monitoring. The NMPs of the FYR Macedonia and Australia provide indicators for monitoring. Conclusions To date, not all countries have a NMP since political pressure by national experts or non-governmental organizations is generally needed to establish a NMP. Case studies in four countries showed that the policy process is just as important as the policy document since the process must create a mechanism by which all stakeholders are brought together and a sense of collective ownership of the final policy may be achieved. PMID:24764540

Effects of pimobendan on myocardial perfusion and pulmonary transit time in dogs with myxomatous mitral valve disease: a pilot study.

PubMed

Apple, S M; Menciotti, G; Braz-Ruivo, L; Crosara, S; Häggström, J; Borgarelli, M

2016-09-01

To describe pulmonary transit time (nPTT) and myocardial perfusion (nMP) normalised to heart rate in dogs with stable ACVIM stage C myxomatous mitral valve disease (MMVD) and to assess short-term effects of pimobendan on these variables. We hypothesised that nPTT and nMP would increase in dogs with MMVD compared with normal dogs. Additionally, we hypothesised that treatment with pimobendan would decrease nMP and nPTT in dogs with MMVD. Prospective, single-blind study involving 6 normal dogs and 12 dogs with MMVD. Dogs with MMVD were treated with enalapril and furosemide for at least 1 month prior to examination. All dogs underwent standard and contrast echocardiographic examinations at the beginning of the study (T0). At this time, MMVD dogs were randomly assigned to receive either pimobendan (0.4-0.6 mg/kg) or not. All dogs with MMVD were re-evaluated by standard and contrast echocardiography after 1 week (T1) and nPTT and nMP were measured. nPTT was significantly increased in dogs with MMVD (P = 0.0063), compared with normal dogs. It was significantly decreased at T1 in dogs receiving pimobendan (P = 0.0250). The nMP was not significantly different in dogs with MMVD, compared with healthy dogs (P = 0.2552), and it was not significantly different at T1 in the treatment group (P = 0.8798). Contrast echocardiography was a valid, complementary tool for echocardiographic analysis of dogs with MMVD. Pimobendan decreased nPTT in dogs affected by MMVD. Myocardial perfusion was not different in dogs with severe MMVD. © 2016 Australian Veterinary Association.

Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy.

PubMed

Saw, Constance Lay Lay; Olivo, Malini; Wohland, Thorsten; Fu, Chit Yaw; Kho, Kiang Wei; Soo, Khee Chee; Sia Heng, Paul Wan

2007-10-01

Photodynamic diagnosis (PDD) using hypericin (HY), a natural photosensitizer, detects bladder cancer significantly better than white light endoscopy. However, the lipophilicity of HY complicates its administration for clinical applications. Currently, pharmaceutical preparations for HY without plasma protein are being developed. Formulations containing a biocompatible solvent, N-methyl pyrrolidone (NMP) have been shown to enhance the photodynamic therapeutic effects of HY. It was recently reported that, NMP formulations of HY were able to produce significantly higher contrast for fluorescence detection of tumors than albumin-containing HY formulations. This present work hypothesizes that NMP acts both as a solvent and penetration enhancer to improve the delivery of HY into cells by increasing the permeability of cell membranes. This paper reports the use of 3-D confocal microscopy to monitor real-time uptake of HY in human carcinoma. 3-D confocal microscopy was used to investigate the possibility of nuclear localization of HY in MGH cells. The fluorescence of HY was confirmed to be emitted from HY containing cells using spectrometry. The localization of a DNA fluorescent probe 4', 6-diamidino-2-phenylindole dihydrochloride (DAPI) was used to confirm the possibility of colocalization of DAPI and HY. The colocalization analysis in the present study suggests that it was very unlikely that HY colocalized in the nucleus that was stained by DAPI. Fluorescein leakage tests showed that 1% NMP changes the permeability of cell membranes, and enhanced the delivery of HY into cells resulting in lower cell survival ratios. Thus, NMP was able to enhance the photodynamic therapeutic effects of HY on cancer cells.

Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone.

PubMed

Poet, T S; Schlosser, P M; Rodriguez, C E; Parod, R J; Rodwell, D E; Kirman, C R

2016-04-01

The developmental effects of NMP are well studied in Sprague-Dawley rats following oral, inhalation, and dermal routes of exposure. Short-term and chronic occupational exposure limit (OEL) values were derived using an updated physiologically based pharmacokinetic (PBPK) model for NMP, along with benchmark dose modeling. Two suitable developmental endpoints were evaluated for human health risk assessment: (1) for acute exposures, the increased incidence of skeletal malformations, an effect noted only at oral doses that were toxic to the dam and fetus; and (2) for repeated exposures to NMP, changes in fetal/pup body weight. Where possible, data from multiple studies were pooled to increase the predictive power of the dose-response data sets. For the purposes of internal dose estimation, the window of susceptibility was estimated for each endpoint, and was used in the dose-response modeling. A point of departure value of 390 mg/L (in terms of peak NMP in blood) was calculated for skeletal malformations based on pooled data from oral and inhalation studies. Acceptable dose-response model fits were not obtained using the pooled data for fetal/pup body weight changes. These data sets were also assessed individually, from which the geometric mean value obtained from the inhalation studies (470 mg*hr/L), was used to derive the chronic OEL. A PBPK model for NMP in humans was used to calculate human equivalent concentrations corresponding to the internal dose point of departure values. Application of a net uncertainty factor of 20-21, which incorporates data-derived extrapolation factors, to the point of departure values yields short-term and chronic occupational exposure limit values of 86 and 24 ppm, respectively. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Nonlinear magneto-plasmonics

DOE PAGES

Zheng, Wei; Liu, Xiao; Hanbicki, Aubrey T.; ...

2015-10-19

Nonlinear magneto-plasmonics (NMP) describes systems where nonlinear optics, magnetics and plasmonics are all involved. In such systems, nonlinear magneto-optical Kerr effect (nonlinear MOKE) plays an important role as a characterization method, and Surface Plasmons (SPs) work as catalyst to induce many new effects. Magnetization-induced second-harmonic generation (MSHG) is the major nonlinear magneto-optical process involved. The new effects include enhanced MSHG, controlled and enhanced magnetic contrast, etc. Nanostructures such as thin films, nanoparticles, nanogratings, and nanoarrays are critical for the excitation of SPs, which makes NMP an interdisciplinary research field in nanoscience and nanotechnology. In this review article, we organize recentmore » work in this field into two categories: surface plasmon polaritons (SPPs) representing propagating surface plasmons, and localized surface plasmons (LSPs), also called particle plasmons. We review the structures, experiments, findings, and the applications of NMP from various groups.« less

Copper coordination polymers from cavitand ligands: hierarchical spaces from cage and capsule motifs, and other topologies† †Electronic supplementary information (ESI) available: Further details of crystallographic studies, thermogravimetric analyses, Raman spectroscopy. CCDC 1401250–1401256. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01801c Click here for additional data file. Click here for additional data file.

PubMed Central

Thorp-Greenwood, Flora L.; Ronson, Tanya K.

2015-01-01

The cyclotriveratrylene-type ligands (±)-tris(iso-nicotinoyl)cyclotriguaiacylene L1 (±)-tris(4-pyridylmethyl)cyclotriguaiacylene L2 and (±)-tris{4-(4-pyridyl)benzyl}cyclotriguaiacylene L3 all feature 4-pyridyl donor groups and all form coordination polymers with CuI and/or CuII cations that show a remarkable range of framework topologies and structures. Complex [CuI 4CuII 1.5(L1)3(CN)6]·CN·n(DMF) 1 features a novel 3,4-connected framework of cyano-linked hexagonal metallo-cages. In complexes [Cu3(L2)4(H2O)3]·6(OTf)·n(DMSO) 2 and [Cu2(L3)2Br2(H2O)(DMSO)]·2Br·n(DMSO) 3 capsule-like metallo-cryptophane motifs are formed which linked through their metal vertices into a hexagonal 2D network of (43.123)(42.122) topology or a coordination chain. Complex [Cu2(L1)2(OTf)2(NMP)2(H2O)2]·2(OTf)·2NMP 4 has an interpenetrating 2D 3,4-connected framework of (4.62.8)(62.8)(4.62.82) topology with tubular channels. Complex [Cu(L1)(NCMe)]·BF4·2(CH3CN)·H2O 5 features a 2D network of 63 topology while the CuII analogue [Cu2(L1)2(NMP)(H2O)]·4BF4·12NMP·1.5H2O 6 has an interpenetrating (10,3)-b type structure and complex [Cu2(L2)2Br3(DMSO)]·Br·n(DMSO) 7 has a 2D network of 4.82 topology. Strategies for formation of coordination polymers with hierarchical spaces emerge in this work and complex 2 is shown to absorb fullerene-C60 through soaking the crystals in a toluene solution. PMID:28791086

Adaptation of the Nomophobia Questionnaire (NMP-Q) to Spanish in a sample of adolescents.

PubMed

González-Cabrera, Joaquín; León-Mejía, Ana; Pérez-Sancho, Carlota; Calvete, Esther

2017-07-01

Nomophobia is the fear of being out of mobile phone contact. People suffering from this anxiety disorder have feelings of stress and nervousness when access to their mobiles or computers is not possible. This work is an adaptation and validation study of the Spanish version of the Nomophobia Questionnaire (NMP-Q). The study included 306 students (46.1% males and 53.9% females) with ages ranging 13 to 19 years (Md=15.41±1.22). Exploratory factor analysis revealed four dimensions that accounted for 64.4% of total variance. The ordinal α-value was 0.95, ranging from 0.75 to 0.92 across factors. Measure of stability was calculated by the testretest method (r=0.823). Indicators of convergence with the Spanish versions of the “Mobile Phone Problem Use Scale” (r=0.654) and the “Generalized Problematic Internet Use Scale” (r=0.531) were identified. Problematic mobile phone use patterns were examined taking the 15P, 80P and 95P percentiles as cut-off points. Scores of 39, 87 and 116 on NMP-Q corresponded to occasional, at-risk and problematic users, respectively. Psychometric analysis shows that the Spanish version of the NMP-Q is a valid and reliable tool for the study of nomophobia.

Influence of educational status and other variables on HIV risk perception among military personnel: A large cohort finding

PubMed Central

Essien, E. James; Ogungbade, Gbadebo O.; Ward, Doriel; Ekong, Ernest; Ross, Michael W.; Meshack, Angela; Holmes, Laurens

2007-01-01

HIV risk perception remains an effective determinant of HIV transmission. Although higher educational attainment has been associated with increased HIV risk perception, this predictor remains to be assessed among Nigerian military personnel (NMP). In a prospective cohort of 2,213 NMP, the effect of education and other factors on HIV risk perception were assessed at baseline using chi square statistic and unconditional logistic regression. There was an inverse correlation between higher educational attainment and HIV risk perception in the univarible model, prevalence odds ratio (POR), 0.64, 95% confidence interval (CI) = 0.52–0.79. This association persisted after adjustment for relevant covariates in the multivariable model (POR, 0.70, 95% CI=0.56–0.88). Likewise, there was a direct correlation between use of alcohol and marijuana and HIV risk perception (p <0.05). In contrast, casual sex and gender were not statistically significantly associated with HIV risk perception, P >0.05. This study is indicative of an inverse correlation between educational attainment and HIV risk perception, as well as a direct correlation between alcohol and marijuana and HIV risk perception among NMP. Therefore HIV prevention interventions targeted at NMP need to include multiple factors that may impact on risk perception regardless of educational status of the participants. PMID:18062392

The NASA/MSFC Coherent Lidar Technology Advisory Team

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.

1999-01-01

The SPAce Readiness Coherent Lidar Experiment (SPARCLE) mission was proposed as a low cost technology demonstration mission, using a 2-micron, 100-mJ, 6-Hz, 25-cm, coherent lidar system based on demonstrated technology. SPARCLE was selected in late October 1997 to be NASA's New Millennium Program (NMP) second earth-observing (EO-2) mission. To maximize the success probability of SPARCLE, NASA/MSFC desired expert guidance in the areas of coherent laser radar (CLR) theory, CLR wind measurement, fielding of CLR systems, CLR alignment validation, and space lidar experience. This led to the formation of the NASA/MSFC Coherent Lidar Technology Advisory Team (CLTAT) in December 1997. A threefold purpose for the advisory team was identified as: 1) guidance to the SPARCLE mission, 2) advice regarding the roadmap of post-SPARCLE coherent Doppler wind lidar (CDWL) space missions and the desired matching technology development plan 3, and 3) general coherent lidar theory, simulation, hardware, and experiment information exchange. The current membership of the CLTAT is shown. Membership does not result in any NASA or other funding at this time. We envision the business of the CLTAT to be conducted mostly by email, teleconference, and occasional meetings. The three meetings of the CLTAT to date, in Jan. 1998, July 1998, and Jan. 1999, have all been collocated with previously scheduled meetings of the Working Group on Space-Based Lidar Winds. The meetings have been very productive. Topics discussed include the SPARCLE technology validation plan including pre-launch end-to-end testing, the space-based wind mission roadmap beyond SPARCLE and its implications on the resultant technology development, the current values and proposed future advancement in lidar system efficiency, and the difference between using single-mode fiber optical mixing vs. the traditional free space optical mixing.

Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

DTIC Science & Technology

1990-04-01

DECISION AIDS HAVE CREATED A VAST NEW POTENTIAL FOR SUPPORT OF STRATEGIC AND TACTICAL OPERATIONS. THE NON-MONOTONIC PROBABILIST (NMP), DEVELOPED BY...QUALITY OF THE NEW DESIGN WILL BE EVALUATED BY CREATING A VIDEO TAPE USING A VIDEO ANIMATION SYSTEM, AND A SOFTWARE SIMULATION OF THE NEW DESIGN. THE...FAULT TOLERANT, SECURE SHIPBOARD COMMUNICATIONS. THE LAN WILL UTILIZE PHOENIX DIGITAL’S FAULT TOLERANT, " SELF - HEALING " SMALL BUSINESS INNOVATION RESEARCH

Tungsten carbide nanorods with zirconium dioxide composite for low cost with high efficiency Pt-free counter electrode in dye sensitized solar cell

NASA Astrophysics Data System (ADS)

Vijayakumar, P.; Senthil Pandian, M.; Ramasamy, P.

2018-04-01

Tungsten carbide nanorods/Zirconium dioxide (WC-NRs/ZrO2) composite material was used as a counter electrode (CE) for efficient dye-sensitized solar cell (DSSC) fabrication. The prepared WC-NRs/ZrO2 (N-Methyl-2-pyrrolidone (NMP)/2-Propanol) gel is drop casted on the FTO substrate for CE. The morphological analysis was confirmed by FESEM and TEM. Nyquist plot clearly indicates that the NMP based WC-NRs/ZrO2 CE possesses high electrocatalytic activity and faster charge-transfer ability for the reduction of I3- due to the lower charge transfer resistance. The fabricated WC-NRs/ZrO2 (NMP) composite CE is demonstrated with high power conversion efficiency (PCE) of 6.63% in comparison to the WC-NRs/ZrO2 (2-propanol) CE of 2.29% under same conditions.

On-orbit test results from the EO-1 Advanced Land Imager

NASA Astrophysics Data System (ADS)

Evans, Jenifer B.; Digenis, Constantine J.; Gibbs, Margaret D.; Hearn, David R.; Lencioni, Donald E.; Mendenhall, Jeffrey A.; Welsh, Ralph D.

2002-01-01

The Advanced Land Imager (ALI) is the primary instrument flown on the first Earth Observing mission (EO-1), launched on November 21, 2000. It was developed under NASA's New Millennium Program (NMP). The NMP mission objective is to flight-validate advanced technologies that will enable dramatic improvements in performance, cost, mass, and schedule for future, Landsat-like, Earth Science Enterprise instruments. ALI contains a number of innovative features designed to achieve this objective. These include the basic instrument architecture which employs a push-broom data collection mode, a wide field of view optical design, compact multi-spectral detector arrays, non-cryogenic HgCdTe for the short wave infrared bands, silicon carbide optics, and a multi-level solar calibration technique. During the first ninety days on orbit, the instrument performance was evaluated by collecting several Earth scenes and comparing them to identical scenes obtained by Landsat7. In addition, various on-orbit calibration techniques were exercised. This paper will present an overview of the EO-1 mission activities during the first ninety days on-orbit, details of the ALI instrument performance and a comparison with the ground calibration measurements.

The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.

PubMed

Laing, Richard W; Bhogal, Ricky H; Wallace, Lorraine; Boteon, Yuri; Neil, Desley A H; Smith, Amanda; Stephenson, Barney T F; Schlegel, Andrea; Hübscher, Stefan G; Mirza, Darius F; Afford, Simon C; Mergental, Hynek

2017-11-01

Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts under near-physiological conditions while maintaining their normal metabolic activity. This process requires an adequate oxygen supply, typically delivered by packed red blood cells (RBC). We present the first experience using an acellular hemoglobin-based oxygen carrier (HBOC) Hemopure in a human model of NMP-L. Five discarded high-risk human livers were perfused with HBOC-based perfusion fluid and matched to 5 RBC-perfused livers. Perfusion parameters, oxygen extraction, metabolic activity, and histological features were compared during 6 hours of NMP-L. The cytotoxicity of Hemopure was also tested on human hepatic primary cell line cultures using an in vitro model of ischemia reperfusion injury. The vascular flow parameters and the perfusate lactate clearance were similar in both groups. The HBOC-perfused livers extracted more oxygen than those perfused with RBCs (O2 extraction ratio 13.75 vs 9.43 % ×10 per gram of tissue, P = 0.001). In vitro exposure to Hemopure did not alter intracellular levels of reactive oxygen species, and there was no increase in apoptosis or necrosis observed in any of the tested cell lines. Histological findings were comparable between groups. There was no evidence of histological damage caused by Hemopure. Hemopure can be used as an alternative oxygen carrier to packed red cells in NMP-L perfusion fluid.

Physiological responses of biomass allocation, root architecture, and invertase activity to copper stress in young seedlings from two populations of Kummerowia stipulacea (maxim.) Makino.

PubMed

Zhang, Luan; Pan, Yuxue; Lv, Wei; Xiong, Zhi-ting

2014-06-01

In the current study, we hypothesize that mine (metallicolous) populations of metallophytes form a trade-off between the roots and shoots when under copper (Cu) stress to adapt themselves to heavy metal contaminated habitats, and thus, differ from normal (non-metallicolous) populations in biomass allocation. To test the hypothesis, two populations of the metallophyte Kummerowia stipulacea, one from an ancient Cu mine (MP) and the other from a non-contaminated site (NMP), were treated with Cu(2+) in hydroponic conditions. The results showed that MP plants had higher root/shoot biomass allocation and more complicated root system architecture compared to those of the NMP plants when under Cu stress. The net photosynthetic capacity was more inhibited in the NMP plants than in the MP plants when under Cu stress. The sugar (sucrose and hexose) contents and acid invertase activities of MP plants were elevated while those in NMP plants were inhibited after Cu treatment. The neutral/alkaline invertase activities and sucrose synthase level showed no significant differences between the two populations when under Cu stress. The results showed that acid invertase played an important role in biomass allocation and that the physiological responses were beneficial for the high root/shoot biomass allocation, which were advantageous during adaptive evolution to Cu-enriched mine soils. Copyright © 2014 Elsevier Inc. All rights reserved.

Influence of educational status and other variables on human immunodeficiency virus risk perception among military personnel: a large cohort finding.

PubMed

Essien, E James; Ogungbade, Gbadebo O; Ward, Doriel; Ekong, Ernest; Ross, Michael W; Meshack, Angela; Holmes, Laurens

2007-11-01

Human immunodeficiency virus (HIV) risk perception remains an effective determinant of HIV transmission. Although higher educational attainment has been associated with increased HIV risk perception, this predictor remains to be assessed among Nigerian military personnel (NMP). In a prospective cohort of 2,213 NMP, the effects of education and other factors on HIV risk perception were assessed at baseline by using the X2 statistic and unconditional logistic regression. There was an inverse correlation between higher educational attainment and HIV risk perception in the univariate model (prevalence odds ratio, 0.64; 95% confidence interval, 0.52-0.79). This association persisted after adjustment for relevant covariates in the multivariate model (prevalence odds ratio, 0.70; 95% confidence interval, 0.56-0.88). Similarly, there was a direct correlation between use of alcohol and marijuana and HIV risk perception (p < 0.05). In contrast, casual sex and gender were not statistically significantly associated with HIV risk perception (p > 0.05). This study indicates an inverse correlation between educational attainment and HIV risk perception, as well as a direct correlation between alcohol and marijuana use and HIV risk perception, among NMP. Therefore, HIV prevention interventions targeted at NMP need to include multiple factors that may affect risk perception regardless of the educational status of the participants.

Identification of second messenger mediating signal transduction in the olfactory receptor cell.

PubMed

Takeuchi, Hiroko; Kurahashi, Takashi

2003-11-01

One of the biggest controversial issues in the research of olfaction has been the mechanism underlying response generation to odorants that have been shown to fail to produce cAMP when tested by biochemical assays with olfactory ciliary preparations. Such observations are actually the original source proposing a possibility for the presence of multiple and parallel transduction pathways. In this study the activity of transduction channels in the olfactory cilia was recorded in cells that retained their abilities of responding to odorants that have been reported to produce InsP3 (instead of producing cAMP, and therefore tentatively termed "InsP3 odorants"). At the same time, the cytoplasmic cNMP concentration ([cNMP]i) was manipulated through the photolysis of caged compounds to examine their real-time interactions with odorant responses. Properties of responses induced by both InsP3 odorants and cytoplasmic cNMP resembled each other in their unique characteristics. Reversal potentials of currents were 2 mV for InsP3 odorant responses and 3 mV for responses induced by cNMP. Current and voltage (I-V) relations showed slight outward rectification. Both responses showed voltage-dependent adaptation when examined with double pulse protocols. When brief pulses of the InsP3 odorant and cytoplasmic cNMP were applied alternatively, responses expressed cross-adaptation with each other. Furthermore, both responses were additive in a manner as predicted quantitatively by the theory that signal transduction is mediated by the increase in cytoplasmic cAMP. With InsP3 odorants, actually, remarkable responses could be detected in a small fraction of cells ( approximately 2%), explaining the observation for a small production of cAMP in ciliary preparations obtained from the entire epithelium. The data will provide evidence showing that olfactory response generation and adaptation are regulated by a uniform mechanism for a wide variety of odorants.

Determination of N-vinyl-2-pyrrolidone and N-methyl-2-pyrrolidone in drugs using polypyrrole-based headspace solid-phase microextraction and gas chromatography-nitrogen-phosphorous detection.

PubMed

Mehdinia, Ali; Ghassempour, Alireza; Rafati, Hasan; Heydari, Rouhollah

2007-03-21

A headspace solid-phase microextraction and gas chromatography-nitrogen-phosphorous detection (HS-SPME-GC-NPD) method using polypyrrole (PPy) fibers has been introduced to determine two derivatives of pyrrolidone; N-vinyl-2-pyrrolidone (NVP) and N-methyl-2-pyrrolidone (NMP). Two types of PPy fibers, prepared using organic and aqueous media, were compared in terms of extraction efficiency and thermal stability. It was found that PPy film prepared using organic medium (i.e. acetonitrile) had higher extraction efficiency and more thermal stability compared to the film prepared in aqueous medium. To enhance the sensitivity of HS-SPME, the effects of pH, ionic strength, extraction time, extraction temperature and the headspace volume on the extraction efficiency were optimized. Using the results of this research, high sensitivity and selectivity had been achieved due to the combination of the high extraction efficiency of PPy film prepared in organic medium and the high sensitivity and selectivity of nitrogen-phosphorous detection. Linear range of the analytes was found to be between 1.0 and 1000 microg L(-1) with regression coefficients (R(2)) of 0.998 and 0.997 for NVP and NMP, consequently. Limits of detection (LODs) were 0.074 and 0.081 microg L(-1) for NVP and NMP, respectively. Relative standard deviation (R.S.D.) for five replications of analyses was found to be less than 6.0%. In real samples the mean recoveries were 94.81% and 94.15% for NVP and NMP, respectively. The results demonstrated the suitability of the HS-SPME technique for analyzing NVP and NMP in two different pharmaceutical matrices. In addition, the method was used for simultaneous detection of NVP, 2-pyrrolidone (2-Pyr), gamma-butyrolactone (GBL) and ethanolamine (EA) compounds.

Identification of Second Messenger Mediating Signal Transduction in the Olfactory Receptor Cell

PubMed Central

Takeuchi, Hiroko; Kurahashi, Takashi

2003-01-01

One of the biggest controversial issues in the research of olfaction has been the mechanism underlying response generation to odorants that have been shown to fail to produce cAMP when tested by biochemical assays with olfactory ciliary preparations. Such observations are actually the original source proposing a possibility for the presence of multiple and parallel transduction pathways. In this study the activity of transduction channels in the olfactory cilia was recorded in cells that retained their abilities of responding to odorants that have been reported to produce InsP3 (instead of producing cAMP, and therefore tentatively termed “InsP3 odorants”). At the same time, the cytoplasmic cNMP concentration ([cNMP]i) was manipulated through the photolysis of caged compounds to examine their real-time interactions with odorant responses. Properties of responses induced by both InsP3 odorants and cytoplasmic cNMP resembled each other in their unique characteristics. Reversal potentials of currents were 2 mV for InsP3 odorant responses and 3 mV for responses induced by cNMP. Current and voltage (I-V) relations showed slight outward rectification. Both responses showed voltage-dependent adaptation when examined with double pulse protocols. When brief pulses of the InsP3 odorant and cytoplasmic cNMP were applied alternatively, responses expressed cross-adaptation with each other. Furthermore, both responses were additive in a manner as predicted quantitatively by the theory that signal transduction is mediated by the increase in cytoplasmic cAMP. With InsP3 odorants, actually, remarkable responses could be detected in a small fraction of cells (∼2%), explaining the observation for a small production of cAMP in ciliary preparations obtained from the entire epithelium. The data will provide evidence showing that olfactory response generation and adaptation are regulated by a uniform mechanism for a wide variety of odorants. PMID:14581582

Leveraging Outreach Efforts for Big-Impact Results

NASA Astrophysics Data System (ADS)

Fisher, D.; Leon, N.

2000-10-01

The U.S. National Aeronautics and Space Administration (NASA) strongly emphasizes the importance of public and educational outreach as an intrinsic part of every space mission. Not only is it necessary to gain and retain public support for space science missions, but also it is an explicit mandate that NASA make every effort to offer genuine and accessible value to the general public in exchange for its support. The product of value is, first of all, information. Of course part of this outreach effort includes industrial technology transfer and free access to raw data for study by science investigators. But an equally important part includes reaching out to a number of different audiences, including those younger members of our society who will soon be choosing their careers, paying taxes, voting, and helping to decide the direction that space exploration and other scientific research will -- or will not -- take in the coming decades. NASA seeks to implement this commitment through each of its space missions Thus, each NASA mission needs include a small budget for public and educational outreach. But how can these missions best use this resource? This paper describes in some detail the approach taken by a small educational outreach team for NASA's New Millennium Program (NMP). The outreach team's approach is twofold: develop a highly desirable suite of products designed to appeal to, as well as inform, a variety of different audiences; then negotiate relationships with existing channels for dissemination of these products. This latter task is normally the most expensive part of outreach. The paper will describe in some detail both the products and the "marketing" approach for those products.

The study of voids in the AuAl thin-film system using the nuclear microprobe

NASA Astrophysics Data System (ADS)

de Waal, H. S.; Pretorius, R.; Prozesky, V. M.; Churms, C. L.

1997-07-01

A Nuclear Microprobe (NMP) was used to study void formation in thin film gold-aluminium systems. Microprobe Rutherford Backscattering Spectrometry (μRBS) was utilised to effectively obtain a three-dimensional picture of the void structure on the scale of a few nanometers in the depth dimension and a few microns in the in-plane dimension. This study illustrates the usefulness of the NMP in the study of materials and specifically thin-film structures.

OPPT workplan risk assessment Methylene Chloride ...

EPA Pesticide Factsheets

These assessments will focus on the use of DCM and NMP in paint stripping. NMP exposures scenarios for this use result in inhalation and dermal exposure to consumers and workers. The low concern for environmental effects of NMP will be discussed in the assessment. In the case of DCM, there are human health concerns for both cancer and non-cancer effects. This DCM assessment of paint stripping uses will focus only on inhalation exposure to consumers and workers. The low concern for environmental effects of DCM will be discussed in the assessment. EPA anticipates issuing draft risk assessments for public review and comment as they are completed. At the conclusion of the review process, if an assessment of specific uses indicates significant risk, EPA will evaluate and pursue appropriate risk reduction actions, as warranted. If an assessment indicates no significant risk, EPA will conclude its current work on assessment of those specified targeted uses of that chemical. Over time, additional chemicals will be added to the work plan as more data are developed and more chemicals screened.

[Preparation of 1-(2-naphthyl) -3-methyl-5-pyrazolone as pre-column derivatization reagent for the determination of saccharides using high performance liquid chromatography-mass spectrometry].

PubMed

Sun, Zhiwei; Liu, Lingjun; Hu, Baojun; Sheng, Xiao; Wang, Xiaoyan; Suo, Yourui; You, Jinmao

2008-03-01

Eight saccharides were derivatized using 1-(2-naphthyl)-3-methyl-5-pyrazolone (NMP) as pre-column derivatizing reagent, and separated on a reversed-phase Hypersil ODS 2 column (4.6 mm x 200 mm, 5 microm), by high performance liquid chromatography (HPLC) in conjunction with a gradient elution, detected by a diode array detector (DAD), and identified by electrospray ionization-mass spectrometry (ESI-MS) in positive ion mode. NMP reacted with reductive saccharides easily in the presence of 17% ammonia water at 70 degrees C. All linear correlation coefficients for saccharide derivatives were over 0.998 5. The detection limits (at signal-to-noise of 3:1) were 0.58 - 1.1 pmol for saccharide derivatives. The characteristic fragment ions, especially m/z 473, from the cleavage of NMP-labeled saccharides exhibited high regularity for the identification of the composition of saccharide mixture. The established method is sensitive and repeatable for the determination of saccharides.

Mutation in a locus linked to penB-nmp causes suppression of the Mtr phenotype of Neisseria gonorrhoeae.

PubMed Central

Shinners, E N; Catlin, B W

1988-01-01

The chromosomal locus mtr, which encodes low-level resistance to multiple antibacterial agents in Neisseria gonorrhoeae, is subject to phenotypic suppression by env mutations that increase the permeability of the envelope. We have identified a new locus, mom (for modifier of Mtr), which is located on the chromosome very close to penB and nmp, loci known to be linked to each other and to spc. Phenotypic suppression of Mtr was recognized by reductions of resistance to benzylpenicillin and also to oxacillin and the hydrophobic agents novobiocin and erythromycin. The resistance to each of these antibiotics returned to the Mtr levels in mom+ transformants isolated by selection for increased resistance to either novobiocin or erythromycin; the accompanying change of the outer membrane protein I seroreactions confirmed the proximity of nmp and mom. Thus, some mutant gonococci display wild-type antibiotic susceptibilities but can express multiple resistance following a mom+ mutation that releases the suppressed Mtr phenotype. PMID:3142343

Nuclear matrix - structure, function and pathogenesis.

PubMed

Wasąg, Piotr; Lenartowski, Robert

2016-12-20

The nuclear matrix (NM), or nuclear skeleton, is the non-chromatin, ribonucleoproteinaceous framework that is resistant to high ionic strength buffers, nonionic detergents, and nucleolytic enzymes. The NM fulfills a structural role in eukaryotic cells and is responsible for maintaining the shape of the nucleus and the spatial organization of chromatin. Moreover, the NM participates in several cellular processes, such as DNA replication/repair, gene expression, RNA transport, cell signaling and differentiation, cell cycle regulation, apoptosis and carcinogenesis. Short nucleotide sequences called scaffold/matrix attachment regions (S/MAR) anchor the chromatin loops to the NM proteins (NMP). The NMP composition is dynamic and depends on the cell type and differentiation stage or metabolic activity. Alterations in the NMP composition affect anchoring of the S/MARs and thus alter gene expression. This review aims to systematize information about the skeletal structure of the nucleus, with particular emphasis on the organization of the NM and its role in selected cellular processes. We also discuss several diseases that are caused by aberrant NM structure or dysfunction of individual NM elements.

A dark brown roast coffee blend is less effective at stimulating gastric acid secretion in healthy volunteers compared to a medium roast market blend.

PubMed

Rubach, Malte; Lang, Roman; Bytof, Gerhard; Stiebitz, Herbert; Lantz, Ingo; Hofmann, Thomas; Somoza, Veronika

2014-06-01

Coffee consumption sometimes is associated with symptoms of stomach discomfort. This work aimed to elucidate whether two coffee beverages, containing similar amounts of caffeine, but differing in their concentrations of (β) N-alkanoyl-5-hydroxytryptamides (C5HTs), chlorogenic acids (CGAs), trigonelline, and N-methylpyridinium (N-MP) have different effects on gastric acid secretion in healthy volunteers. The intragastric pH after administration of bicarbonate with/without 200 mL of a coffee beverage prepared from a market blend or dark roast blend was analyzed in nine healthy volunteers. Coffee beverages were analyzed for their contents of C5HT, N-MP, trigonelline, CGAs, and caffeine using HPLC-DAD and HPLC-MS/MS. Chemical analysis revealed higher concentrations of N-MP for the dark brown blend (87 mg/L) compared to the market blend coffee (29 mg/L), whereas concentrations of C5HT (0.012 versus 0.343 mg/L), CGAs (323 versus 1126 mg/L), and trigonelline (119 versus 343 mg/L) were lower, and caffeine concentrations were similar (607 versus 674 mg/mL). Gastric acid secretion was less effectively stimulated after administration of the dark roast blend coffee compared to the market blend. Future studies are warranted to verify whether a high ratio of N-MP to C5HT and CGAs is beneficial for reducing coffee-associated gastric acid secretion. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Micropore-induced Capillarity Enhances Bone Distribution in vivo in Biphasic Calcium Phosphate Scaffolds

PubMed Central

Rustom, Laurence E.; Boudou, Thomas; Lou, Siyu; Pignot-Paintrand, Isabelle; Nemke, Brett W.; Lu, Yan; Markel, Mark D.; Picart, Catherine; Wagoner Johnson, Amy J.

2016-01-01

The increasing demand for bone repair solutions calls for the development of efficacious bone scaffolds. Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) have improved healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. Here, we evaluate capillarity induced by micropores as a mechanism that can affect bone growth in vivo. Three groups of cylindrical scaffolds were implanted in pig mandibles for three weeks: MP were implanted either dry (MP-Dry), or after submersion in phosphate buffered saline, which fills pores with fluid and therefore suppresses micropore-induced capillarity (MP-Wet); NMP were implanted dry. The amount and distribution of bone in the scaffolds were quantified using micro-computed tomography. MP-Dry had a more homogeneous bone distribution than MP-Wet, although the average bone volume fraction, BVF¯, was not significantly different for these two groups (0.45±0.03 and 0.37±0.03, respectively). There was no significant difference in the radial bone distribution of NMP and MP-Wet, but the BVF¯ of NMP was significantly lower among the three groups (0.25±0.02). These results suggest that micropore-induced capillarity enhances bone regeneration by improving the homogeneity of bone distribution in BCP scaffolds. The explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. PMID:27544807

The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion

PubMed Central

Wallace, Lorraine; Boteon, Yuri; Neil, Desley AH; Smith, Amanda; Stephenson, Barney TF; Schlegel, Andrea; Hübscher, Stefan G; Mirza, Darius F

2017-01-01

Background Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts under near-physiological conditions whilst maintaining their normal metabolic activity. This process requires an adequate oxygen supply, typically delivered by packed red blood cells (RBC). We present the first experience using an acellular hemoglobin-based oxygen carrier (HBOC) Hemopure in a human model of NMP-L. Methods Five discarded high-risk human livers were perfused with HBOC-based perfusion fluid and matched to 5 RBC-perfused livers. Perfusion parameters, oxygen extraction, metabolic activity and histological features were compared during 6 hours of NMP-L. The cytotoxicity of Hemopure was also tested on human hepatic primary cell line cultures using an in vitro model of ischemia reperfusion injury. Results The vascular flow parameters and the perfusate lactate clearance were similar in both groups. The HBOC-perfused livers extracted more oxygen than those perfused with RBCs (O2ER 13.75 vs 9.43 % x105 per gram of tissue, p=0.001). In vitro exposure to Hemopure did not alter intracellular levels of reactive oxygen species and there was no increase in apoptosis or necrosis observed in any of the tested cell lines. Histological findings were comparable between groups. There was no evidence of histological damage caused by Hemopure. Conclusion Hemopure can be used as an alternative oxygen carrier to packed red cells in NMP-L perfusion fluid. PMID:28520579

Microwave-assisted extraction of polycyclic aromatic compounds from coal.

PubMed

Kerst, M; Andersson, J T

2001-08-01

Microwave-assisted extraction (MAE) of polycyclic aromatic compounds (PACs) from coal is shown to give the same pattern of compounds as Soxhlet extraction. MAE requires only 10 mL solvent and 10 min extraction time whereas Soxhlet uses 200 mL and takes 24 h. Although the yields were lower, dichloromethane (DCM) was preferred to pyridine, N-methyl-2-pyrrolidone (NMP), and NMP with CS2 because the pattern of the PACs is shown to be independent of solvent and DCM is a much more convenient solvent to work with.

Image Stability Requirements For a Geostationary Imaging Fourier Transform Spectrometer (GIFTS)

NASA Technical Reports Server (NTRS)

Bingham, G. E.; Cantwell, G.; Robinson, R. C.; Revercomb, H. E.; Smith, W. L.

2001-01-01

A Geostationary Imaging Fourier Transform Spectrometer (GIFTS) has been selected for the NASA New Millennium Program (NMP) Earth Observing-3 (EO-3) mission. Our paper will discuss one of the key GIFTS measurement requirements, Field of View (FOV) stability, and its impact on required system performance. The GIFTS NMP mission is designed to demonstrate new and emerging sensor and data processing technologies with the goal of making revolutionary improvements in meteorological observational capability and forecasting accuracy. The GIFTS payload is a versatile imaging FTS with programmable spectral resolution and spatial scene selection that allows radiometric accuracy and atmospheric sounding precision to be traded in near real time for area coverage. The GIFTS sensor combines high sensitivity with a massively parallel spatial data collection scheme to allow high spatial resolution measurement of the Earth's atmosphere and rapid broad area coverage. An objective of the GIFTS mission is to demonstrate the advantages of high spatial resolution (4 km ground sample distance - gsd) on temperature and water vapor retrieval by allowing sampling in broken cloud regions. This small gsd, combined with the relatively long scan time required (approximately 10 s) to collect high resolution spectra from geostationary (GEO) orbit, may require extremely good pointing control. This paper discusses the analysis of this requirement.

Flight Test Results of the Earth Observing-1 Advanced Land Imager Advanced Land Imager

NASA Astrophysics Data System (ADS)

Mendenhall, Jeffrey A.; Lencioni, Donald E.; Hearn, David R.; Digenis, Constantine J.

2002-09-01

The Advanced Land Imager (ALI) is the primary instrument on the Earth Observing-1 spacecraft (EO-1) and was developed under NASA's New Millennium Program (NMP). The NMP mission objective is to flight-validate advanced technologies that will enable dramatic improvements in performance, cost, mass, and schedule for future, Landsat-like, Earth Science Enterprise instruments. ALI contains a number of innovative features designed to achieve this objective. These include the basic instrument architecture, which employs a push-broom data collection mode, a wide field-of-view optical design, compact multi-spectral detector arrays, non-cryogenic HgCdTe for the short wave infrared bands, silicon carbide optics, and a multi-level solar calibration technique. The sensor includes detector arrays that operate in ten bands, one panchromatic, six VNIR and three SWIR, spanning the range from 0.433 to 2.35 μm. Launched on November 21, 2000, ALI instrument performance was monitored during its first year on orbit using data collected during solar, lunar, stellar, and earth observations. This paper will provide an overview of EO-1 mission activities during this period. Additionally, the on-orbit spatial and radiometric performance of the instrument will be compared to pre-flight measurements and the temporal stability of ALI will be presented.

Design and implementation of satellite formations and constellations

NASA Technical Reports Server (NTRS)

Folta, David; Newman, Lauri Kraft; Quinn, David

1998-01-01

The direction to develop small low cost spacecraft has led many scientists to recognize the advantage of flying spacecraft in constellations and formations to achieve the correlated instrument measurements formerly possible only by flying many instruments on a single large platform. Yet, constellations and formation flying impose additional complications on orbit selection and orbit maintenance, especially when each spacecraft has its own orbit or science requirements. The purpose of this paper is to develop an operational control method for maintenance of these missions. Examples will be taken from the Earth Observing-1 (EO-1) spacecraft that is part of the New Millennium Program (NMP) and from proposed Earth System Science Program Office (ESSPO) constellations. Results can be used to determine the appropriateness of constellations and formation flying for a particular case as well as the operational impacts. Applications to the ESSPO and NMP are highly considered in analysis and applications. After constellation and formation analysis is completed, implementation of a maneuver maintenance strategy becomes the driver. Advances in technology and automation by GSFC's Guidance, Navigation, and Control Center allow more of the burden of the orbit selection and maneuver maintenance to be automated and ultimately placed onboard the spacecraft, mitigating most of the associated operational concerns. This paper presents the GSFC closed-loop control method to fly in either constellations or formations through the use of an autonomous closed loop three-axis navigation control and innovative orbit maintenance support. Simulation results using AutoCon(TM) and FreeFlyer(TM) with various fidelity levels of modeling and algorithms are presented.

Design and Implementation of Satellite Formations and Constellations

NASA Technical Reports Server (NTRS)

Folta, David; Newman, Lauri Kraft; Quinn, David

1998-01-01

The direction to develop small low cost spacecraft has led many scientists to recognize the advantage of flying spacecraft in constellations and formations to achieve the correlated instrument measurements formerly possible only by flying many instruments on a single large platform. Yet, constellations and formation flying impose additional complications on orbit selection and orbit maintenance, especially when each spacecraft has its own orbit or science requirements. The purpose of this paper is to develop an operational control method for maintenance of these missions. Examples will be taken from the Earth Observing-1 (EO-1) spacecraft that is part of the New Millennium Program (NMP) and from proposed Earth System Science Program Office (ESSPO) constellations. Results can be used to determine the appropriateness of constellations and formation flying for a particular case as well as the operational impacts. Applications to the ESSPO and NMP are highly considered in analysis and applications. After constellation and formation analysis is completed, implementation of a maneuver maintenance strategy becomes the driver. Advances in technology and automation by GSFC's Guidance, Navigation, and Control Center allow more of the burden of the orbit selection and maneuver maintenance to be automated and ultimately placed onboard the spacecraft, mitigating most of the associated operational concerns. This paper presents the GSFC closed-loop control method to fly in either constellations or formations through the use of an autonomous closed loop three-axis navigation control and innovative orbit maintenance support. Simulation results using AutoCon(Trademark) and FreeFlyer(Trademark) with various fidelity levels of modeling and algorithms are presented.

Normothermic machine perfusion of donor livers without the need for human blood products

PubMed Central

Matton, Alix P. M.; Burlage, Laura C.; van Rijn, Rianne; de Vries, Yvonne; Karangwa, Shanice A.; Nijsten, Maarten W.; Gouw, Annette S. H.; Wiersema‐Buist, Janneke; Adelmeijer, Jelle; Westerkamp, Andrie C.; Lisman, Ton

2018-01-01

Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed by using human blood products including red blood cells (RBCs) and fresh frozen plasma (FFP). Our aim was to examine the efficacy of a novel machine perfusion solution based on polymerized bovine hemoglobin‐based oxygen carrier (HBOC)‐201. Twenty‐four livers declined for transplantation were transported by using static cold storage. Upon arrival, livers underwent NMP for 6 hours using pressure‐controlled portal and arterial perfusion. A total of 12 livers were perfused using a solution based on RBCs and FFPs (historical cohort), 6 livers with HBOC‐201 and FFPs, and another 6 livers with HBOC‐201 and gelofusine, a gelatin‐based colloid solution. Compared with RBC + FFP perfused livers, livers perfused with HBOC‐201 had significantly higher hepatic adenosine triphosphate content, cumulative bile production, and portal and arterial flows. Biliary secretion of bicarbonate, bilirubin, bile salts, and phospholipids was similar in all 3 groups. The alanine aminotransferase concentration in perfusate was lower in the HBOC‐201–perfused groups. In conclusion, NMP of human donor livers can be performed effectively using HBOC‐201 and gelofusine, eliminating the need for human blood products. Perfusing livers with HBOC‐201 is at least similar to perfusion with RBCs and FFP. Some of the biomarkers of liver function and injury even suggest a possible superiority of an HBOC‐201–based perfusion solution and opens a perspective for further optimization of machine perfusion techniques. Liver Transplantation 24 528–538 2018 AASLD. PMID:29281862

N-methyl pyrrolidone/bone morphogenetic protein-2 double delivery with in situ forming implants.

PubMed

Karfeld-Sulzer, Lindsay S; Ghayor, Chafik; Siegenthaler, Barbara; de Wild, Michael; Leroux, Jean-Christophe; Weber, Franz E

2015-04-10

Bone morphogenetic proteins (BMPs) are growth and differentiation factors involved during development in morphogenesis, organogenesis and later mainly in regeneration processes, in particular in bone where they are responsible for osteoinduction. For more than a decade, recombinant human (rh)BMP-2 has been used in the clinic for lumbar spinal fusion at non-physiological high dosages that appear to be causative for side effects, like male sterility. A possible strategy to reduce the effective amount of rhBMP-2 in the clinic is the co-delivery with an enhancer of BMPs' activity. In an earlier study, we showed that N-methylpyrrolidone (NMP) enhances BMP activity in vitro and in vivo. Here we report on the development of a slow and sustained double delivery of rhBMP-2 and NMP via an in situ forming implant based on poly(lactide-co-glycolide). The results showed that the release of NMP can be adjusted by varying the lactide/glycolide ratio and the polymer's molecular weight. The same applied to rhBMP-2, with release rates that could be sustained from two to three weeks. In the in vivo model of a critical size defect in the calvarial bone of rabbits, the implant containing 50mol% lactide performed better than the one having 75mol% lactide in terms of defect bridging and extent of bony regenerated area. In situ forming implants for the double delivery of the BMP enhancer NMP and rhBMP-2 appear to be promising delivery systems in bone regeneration. Copyright © 2015 Elsevier B.V. All rights reserved.

NMP22 BladderChek Test: point-of-care technology with life- and money-saving potential.

PubMed

Tomera, Kevin M

2004-11-01

A new, relatively obscure tumor marker assay, the NMP22 BladderChek Test (Matritech, Inc.), represents a paradigm shift in the diagnosis and management of urinary bladder cancer (transitional cell carcinoma). Specifically, BladderChek should be employed every time a cystoscopy is performed, with corresponding changes in the diagnostic protocol and the guidelines of the American Urological Association for the diagnosis and management of bladder cancer. Currently, cystoscopy is the reference standard and NMP22 BladderChek Test in combination with cystoscopy improves the performance of cystoscopy. At every stage of disease, BladderChek provides a higher sensitivity for the detection of bladder cancer than cytology, which now represents the adjunctive standard of care. Moreover, BladderChek is four-times more sensitive than cytology and is available at half the cost. Early detection of bladder cancer improves prognosis, quality of life and survival. BladderChek may be analogous to the prostate-specific antigen test and eventually expand beyond the urologic setting into the primary care setting for the testing of high-risk patients characterized by smoking history, occupational exposures or age.

National Medicines Policy in retrospective: a review of (almost) 20 years of implementation.

PubMed

Vasconcelos, Daniela Moulin Maciel de; Chaves, Gabriela Costa; Azeredo, Thiago Botelho; Silva, Rondineli Mendes da

2017-08-01

Pharmaceutical services and the formulation of a medicines policy are SUS areas ensured by the organic health care law 8,080/90. Thus, after a widely participative process, involving stakeholders, the National Medicines Policy (NMP) was approved in 1998 by Ordinance 3,916.The NMP presents directives and priorities, aligned with organic health care law, which should guide the federal, states and municipals entities actions to achieve the policy goals. Considering almost 20 years of the NMP, this paper took stock discussed some of the directives in light of the SUS principles. It was not the objective to provide an exhaustive review of all the activities performed during this period. The authors tried to get close to those that have brought advances and dilemmas, with potential risk of regression. Efforts to implement an ambitious agenda applied to pharmaceutical services were identified. This agenda tried to deal with different challenges like the dynamics of the pharmaceutical market and the operation of pharmaceutical services to guarantee the supply of medicines aligned with principles and directives of SUS.

The Integration, Testing and Flight of the EO-1 GPS

NASA Technical Reports Server (NTRS)

Quinn, David A.; Sanneman, Paul A.; Shulman, Seth E.; Sager, Jennifer A.

2001-01-01

The Global Positioning System has long been hailed as the wave of the future for autonomous on-board navigation of low Earth orbiting spacecraft despite the fact that relatively few spacecraft have actually employed it for this purpose. While several missions operated out of the Goddard Space Flight Center have flown GPS receivers on board, the New Millenium Program (NMP) Earth Orbiting-1 (EO-1) spacecraft is the first to employ GPS for active, autonomous on-board navigation. Since EO-1 was designed to employ GPS as its primary source of the navigation ephemeris, special care had to be taken during the integration phase of spacecraft construction to assure proper performance. This paper is a discussion of that process: a brief overview of how the GPS works, how it fits into the design of the EO-1 Attitude Control System (ACS), the steps taken to integrate the system into the EO-1 spacecraft, the ultimate on-orbit performance during launch and early operations of the EO-1 mission and the performance of the on-board GPS ephemeris versus the ground based ephemeris. Conclusions will include a discussion of the lessons learned.

The Effects of Alkali and Temperature on the Hydrolysis Rate of N-methylpyrrolidone

NASA Astrophysics Data System (ADS)

Ou, Yu Jing; Wang, Xiao Mei; Lei Li, Chun; Zhu, Ya Long; Li, Xiao Long

2017-12-01

By studying the hydrolysis of N-methylpyrrolidone, it was found that the effects of NaOH concentration and temperature on N-methylpyrrolidone's hydrolysis were remarkable. Fourier transform infrared (FTIR) and Gel Permeation Chromatography (GPC) detected that the mainly hydrolyzate was 4-(methylamino)butyric acid, and the hydrolyzate can generate polymers, which of molecular weight increases with temperature rising. The results of Gas Chromatography (GC) and moisture meter test showed that adding alkaline and raising temperature can aggravate hydrolysis of NMP. This study provide theoretical basis for recycling solvent (NMP) in the production of polyphenylene sulfide (PPS).

Challenges in Catalytic Manufacture of Renewable Pyrrolidinones from Fermentation Derived Succinate

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, James F.; Holladay, Johnathan E.; Zacher, Alan H.

2014-09-05

Fermentation derived succinic acid ammonium salt is an ideal precursor for manufacture of renewable N-methyl pyrrolidinone (NMP) or 2-pyrrolidinone (2P) via heterogeneous catalysis. However, there are many challenges to making this a practical reality. Chief among the challenges is avoiding catalyst poisoning by fermentation by- and co-products. Battelle / Pacific Northwest National Laboratory (PNNL) have developed an economically effective technology strategy for this purpose. The technology is a combination of purely thermal processing, followed by simple catalytic hydrogenation that together avoids catalyst poisoning from fermentation impurities and provides high selectivity and yields of NMP or 2P.

NASA Tech Briefs, October 2008

NASA Technical Reports Server (NTRS)

2008-01-01

Topics covered include: Control Architecture for Robotic Agent Command and Sensing; Algorithm for Wavefront Sensing Using an Extended Scene; CO2 Sensors Based on Nanocrystalline SnO2 Doped with CuO; Improved Airborne System for Sensing Wildfires; VHF Wide-Band, Dual-Polarization Microstrip-Patch Antenna; Onboard Data Processor for Change-Detection Radar Imaging; Using LDPC Code Constraints to Aid Recovery of Symbol Timing; System for Measuring Flexing of a Large Spaceborne Structure; Integrated Formation Optical Communication and Estimation System; Making Superconducting Welds between Superconducting Wires; Method for Thermal Spraying of Coatings Using Resonant-Pulsed Combustion; Coating Reduces Ice Adhesion; Hybrid Multifoil Aerogel Thermal Insulation; SHINE Virtual Machine Model for In-flight Updates of Critical Mission Software; Mars Image Collection Mosaic Builder; Providing Internet Access to High-Resolution Mars Images; Providing Internet Access to High-Resolution Lunar Images; Expressions Module for the Satellite Orbit Analysis Program Virtual Satellite; Small-Body Extensions for the Satellite Orbit Analysis Program (SOAP); Scripting Module for the Satellite Orbit Analysis Program (SOAP); XML-Based SHINE Knowledge Base Interchange Language; Core Technical Capability Laboratory Management System; MRO SOW Daily Script; Tool for Inspecting Alignment of Twinaxial Connectors; An ATP System for Deep-Space Optical Communication; Polar Traverse Rover Instrument; Expert System Control of Plant Growth in an Enclosed Space; Detecting Phycocyanin-Pigmented Microbes in Reflected Light; DMAC and NMP as Electrolyte Additives for Li-Ion Cells; Mass Spectrometer Containing Multiple Fixed Collectors; Waveguide Harmonic Generator for the SIM; Whispering Gallery Mode Resonator with Orthogonally Reconfigurable Filter Function; Stable Calibration of Raman Lidar Water-Vapor Measurements; Bimaterial Thermal Compensators for WGM Resonators; Root Source Analysis/ValuStream[Trade Mark] - A Methodology for Identifying and Managing Risks; Ensemble: an Architecture for Mission-Operations Software; Object Recognition Using Feature-and Color-Based Methods; On-Orbit Multi-Field Wavefront Control with a Kalman Filter; and The Interplanetary Overlay Networking Protocol Accelerator.

Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States.

PubMed

Elbadawi, Lina I; Talley, Pamela; Rolfes, Melissa A; Millman, Alexander J; Reisdorf, Erik; Kramer, Natalie A; Barnes, John R; Blanton, Lenee; Christensen, Jaime; Cole, Stefanie; Danz, Tonya; Dreisig, John J; Garten, Rebecca; Haupt, Thomas; Isaac, Beth M; Jackson, Mary Anne; Kocharian, Anna; Leifer, Daniel; Martin, Karen; McHugh, Lisa; McNall, Rebecca J; Palm, Jennifer; Radford, Kay W; Robinson, Sara; Rosen, Jennifer B; Sakthivel, Senthilkumar K; Shult, Peter; Strain, Anna K; Turabelidze, George; Webber, Lori A; Weinberg, Meghan Pearce; Wentworth, David E; Whitaker, Brett L; Finelli, Lyn; Jhung, Michael A; Lynfield, Ruth; Davis, Jeffrey P

2018-03-30

During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Using a standardized questionnaire, we collected demographic and clinical information. Buccal samples were tested at the CDC for selected viruses, including mumps, influenza, human parainfluenza viruses (HPIVs) 1-4, adenoviruses, cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex viruses (HSVs) 1 and 2, and human herpes viruses (HHVs) 6A and 6B. Among the 320 patients, 65% were male, median age was 14.5 years (range, 0-90), and 67% reported unilateral parotitis. Commonly reported symptoms included sore throat (55%) and fever (48%). Viruses were detected in 210 (71%) of 294 NMP patients with adequate samples for testing, ≥2 viruses were detected in 37 samples, and 248 total virus detections were made among all samples. These included 156 influenza A(H3N2), 42 HHV6B, 32 EBV, 8 HPIV2, 2 HPIV3, 3 adenovirus, 4 HSV-1, and 1 HSV-2. Influenza A(H3N2), HHV6B, and EBV were the most frequently codetected viruses. Our findings suggest that, in addition to mumps, clinicians should consider respiratory viral (influenza) and herpes viral etiologies for parotitis, particularly among patients without epidemiologic links to mumps cases or outbreaks.

A novel ropivacaine-loaded in situ forming implant prolongs the effect of local analgesia in rats

PubMed Central

Lu, Lei; Zhang, Wei; Wu, Xin; Wang, Xiaoyu; Zhang, Min; Zhu, Quangang; Ding, Xueying; Xu, Zhiyun

2012-01-01

Introduction Prolonged postoperative analgesia cannot be achieved by a single injection of local anesthetic solution. The objective of this study was to optimize the formulation of a ropivacaine hydrochloride (Ropi-HCl) loaded in situ forming implant (ISI) by addition of different co-solvents, and evaluate the in vitro release of Ropi-HCl, and the analgesic effect and toxicity of the optimized formulation in rats. Material and methods Triacetin (TA), benzyl benzoate (BB) and polyethylene glycol 400 (PEG 400) were used as additives and added to the solvent of N-methyl-2-pyrrolidone (NMP). Drug release to the surface and inner structural properties of the formed implant were evaluated by scanning electron microscopy (SEM). The analgesic effect was determined by injection near the rat sciatic nerve. Results The solvent system added with TA or BB significantly decreased the burst release, whereas PEG 400 increased the Ropi-HCl burst release from the formulation. Over 70% of the incorporated Ropi-HCl was released from all formulations in 14 days in the in vitro assay. The SEM showed that the surface of NMP-BB formulation was less porous and more homogeneous, compared with the other formulations. Compared with Ropi-HCl injection, the optimized formulation (NMP-BB) significantly prolonged the analgesic effect in 48 h (p < 0.05), with a mild degree of motor block from 3 h to 12 h. Histological evaluation of the injection site revealed only mild inflammatory infiltration without obvious pathological nerve alterations. Conclusions The biodegradable Ropi-HCl-loaded ISI system with NMP-BB may prove to be an attractive and safe alternative for the delivery of parenteral local anesthetics to prolong pain relief. PMID:24049519

The 24-hour normothermic machine perfusion of discarded human liver grafts.

PubMed

Vogel, Thomas; Brockmann, Jens G; Quaglia, Alberto; Morovat, Alireza; Jassem, Wayel; Heaton, Nigel D; Coussios, Constantin C; Friend, Peter J

2017-02-01

Donor organ shortage necessitates use of less than optimal donor allografts for transplantation. The current cold storage preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation (NMP) of liver allografts. In this study, we analyze discarded human liver grafts that underwent NMP for the extended period of 24 hours. Thirteen human liver grafts which had been discarded for transplantation were entered into this study. Perfusion was performed with an automated device using an oxygenated, sanguineous perfusion solution at normothermia. Automated control was incorporated for temperature-, flow-, and pressure-regulation as well as oxygenation. All livers were perfused for 24 hours; parameters of biochemical and synthetic liver function as well as histological parameters of liver damage were analyzed. Livers were stratified for expected viability according to the donor's medical history, procurement data, and their macroscopic appearance. Normothermic perfusion preservation of human livers for 24 hours was shown to be technically feasible. Human liver grafts, all of which had been discarded for transplantation, showed levels suggesting organ viability with respect to metabolic and synthetic liver function (to varying degrees). There was positive correlation between instantly available perfusion parameters and generally accepted predictors of posttransplant graft survival. In conclusion, NMP is feasible reliably for periods of at least 24 hours, even in highly suboptimal donor organs. Potential benefits include not only viability testing (as suggested in recent clinical implementations), but also removal of the time constraints associated with the utilization of high-risk livers, and recovery of ischemic and other preretrieval injuries (possibly by enabling therapeutic strategies during NMP). Liver Transplantation 23 207-220 2017 AASLD. © 2016 by the American Association for the Study of Liver Diseases.

Mission Operations with an Autonomous Agent

NASA Technical Reports Server (NTRS)

Pell, Barney; Sawyer, Scott R.; Muscettola, Nicola; Smith, Benjamin; Bernard, Douglas E.

1998-01-01

The Remote Agent (RA) is an Artificial Intelligence (AI) system which automates some of the tasks normally reserved for human mission operators and performs these tasks autonomously on-board the spacecraft. These tasks include activity generation, sequencing, spacecraft analysis, and failure recovery. The RA will be demonstrated as a flight experiment on Deep Space One (DSI), the first deep space mission of the NASA's New Millennium Program (NMP). As we moved from prototyping into actual flight code development and teamed with ground operators, we made several major extensions to the RA architecture to address the broader operational context in which PA would be used. These extensions support ground operators and the RA sharing a long-range mission profile with facilities for asynchronous ground updates; support ground operators monitoring and commanding the spacecraft at multiple levels of detail simultaneously; and enable ground operators to provide additional knowledge to the RA, such as parameter updates, model updates, and diagnostic information, without interfering with the activities of the RA or leaving the system in an inconsistent state. The resulting architecture supports incremental autonomy, in which a basic agent can be delivered early and then used in an increasingly autonomous manner over the lifetime of the mission. It also supports variable autonomy, as it enables ground operators to benefit from autonomy when L'@ey want it, but does not inhibit them from obtaining a detailed understanding and exercising tighter control when necessary. These issues are critical to the successful development and operation of autonomous spacecraft.

Morphology and kinetics of the formation of polyamide benzimidazole in N-methylpyrrolidone

NASA Astrophysics Data System (ADS)

Khanchich, O. A.; Larionov, V. B.; Biryukov, A. L.

2018-02-01

Polymerization-optical methods were used to study the supermolecular structure in the gelation of systems based on polyamidobenzimidazole (PABI) in N-methylpyrrolidone (N-MP) and the kinetics of phase transformations during polymer coagulation from a the solution. It was found that the use of N-MP leads to the appearance in the PABI-N-MP-H2O system of spherulites having a structure characteristic of LC structures. It is shown that the alternation of metastable structures upon gelation of the PABY - N-MP-H2O system is consistent with the appearance of the LC phase of the cholesteric type.

Shear Rheology of Suspensions of Porous Zeolite Particles in Concentrated Polymer Solutions

NASA Astrophysics Data System (ADS)

Olanrewaju, Kayode O.; Breedveld, Victor

2008-07-01

We present experimental data on the shear rheology of Ultem (polyetherimide)/NMP(l-methyl-2-pyrrolidinone) solutions with and without suspended surface-modified porous/nonporous zeolite (ZSM-5) particles. We found that the porous zeolite suspensions have relative viscosities that significantly exceed the Krieger-Dougherty predictions for hard sphere suspensions. The major origin of this discrepancy is the selective absorption of NMP solvent into the zeolite pores, which raises both the polymer concentration and the particle volume fraction, thus enhancing both the viscosity of the continuous phase Ultem/NMP polymer solution and the particle contribution to the suspension viscosity. Other factors, such as zeolite non-sphericity and specific interactions with Ultem polymer, contribute to the suspension viscosity to a lesser extent. We propose a predictive model for the viscosity of porous zeolite suspensions by incorporating an absorption parameter, α, into the Krieger-Dougherty model. We also propose independent approaches to determine α. The first one is indirect and based on zeolite density/porosity data, assuming that all pores will be filled with solvent. The other method is based on our experimental data, by comparing the viscosity data of porous versus non-porous zeolite suspensions. The different approaches are compared.

Energy impact of cathode drying and solvent recovery during lithium-ion battery manufacturing

NASA Astrophysics Data System (ADS)

Ahmed, Shabbir; Nelson, Paul A.; Gallagher, Kevin G.; Dees, Dennis W.

2016-08-01

Successful deployment of electric vehicles requires maturity of the manufacturing process to reduce the cost of the lithium ion battery (LIB) pack. Drying the coated cathode layer and subsequent recovery of the solvent for recycle is a vital step in the lithium ion battery manufacturing plant and offers significant potential for cost reduction. A spreadsheet model of the drying and recovery of the solvent, is used to study the energy demand of this step and its contribution towards the cost of the battery pack. The base case scenario indicates that the drying and recovery process imposes an energy demand of ∼10 kWh per kg of the solvent n-methyl pyrrolidone (NMP), and is almost 45 times the heat needed to vaporize the NMP. For a plant producing 100 K battery packs per year for 10 kWh plug-in hybrid vehicles (PHEV), the energy demand is ∼5900 kW and the process contributes 107 or 3.4% to the cost of the battery pack. The cost of drying and recovery is equivalent to 1.12 per kg of NMP recovered, saving 2.08 per kg in replacement purchase.

Effect of solvents on the electrochemical properties of binder-free sulfur cathode films in lithium–sulfur batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryu, Ho-Suk; Kim, Byeong-Wook; Park, Jin-Woo

Highlights: • The binder-free sulfur electrode with high sulfur contents of 75 wt.% was fabricated. • The binder-free sulfur electrode using NMP solvents showed 784 mAh g{sup −1} after 40 cycles. • The solvent affect the electrochemical properties of binder-free sulfur electrode films. - Abstract: The effects of solvents on the preparation of sulfur cathodes were investigated by fabricating binder-free sulfur electrode films using three different solvents: 1-methyl-2-pyrrolidinone (NMP), acetonitrile, and deionized water. These solvents are commonly employed to dissolve binders used to prepare sulfur cathodes for lithium–sulfur batteries. The sulfur electrode fabricated with NMP had a higher discharge capacitymore » and longer cycle life than the ones fabricated with acetonitrile and deionized water. Better adhesion between the current collector and the sulfur electrode accounted for the improved capacity and cycle life of the battery. In addition, the stability of the electrode in the electrolyte was a result of the solubility of sulfur in the solvent. We thus concluded that the solvents used in the fabrication of sulfur electrodes had a positive influence on the electrochemical properties of Li–S batteries.« less

Prescription medication by physiotherapists: a Brazilian view of the United Kingdom, Canada, Australia and New Zealand.

PubMed

Costa, Valton da Silva

2017-07-01

Many health systems (HS) have adopted novel models of care which have included non-medical prescription (NMP) by physiotherapists. The aim of this study was to verify in the literature the existence of this practice and its possible benefits. A literature review was carried out through search on Science Direct, PubMed, SciELO, Lilacs and Google Scholar, and in the World Confederation for Physical Therapy and Chartered Society of Physiotherapy websites. In recent decades the United Kingdom adopted the NMP for health professionals, followed by Canada. In Australia and New Zealand physiotherapists have acted in the prescription and administration of medications under medical orders, which is the first step into independent prescription. Brazilian physiotherapists cannot prescribe any medication, despite of high demands from patients in the Brazilian HS, shortage of physicians in many regions and bureaucracy in accessing health services. The adoption of NMP by physiotherapists may play an important role in the HS, and it seems to be an inevitable achievement in the next years in Australia and New Zealand. The main benefits include decreasing bureaucracy for assistance, population demands for medication as well as major professional refinement.

Translation and Validation of the Nomophobia Questionnaire in the Italian Language: Exploratory Factor Analysis

PubMed Central

Argumosa-Villar, Lidia; Boada-Grau, Joan; Vigil-Colet, Andreu; Yildirim, Caglar; Del Puente, Giovanni; Watad, Abdulla

2018-01-01

Background Nomophobia, which is a neologism derived from the combination of “no mobile,” “phone,” and “phobia” is considered to be a modern situational phobia and indicates a fear of feeling disconnected. Objective No psychometric scales are available in Italian for investigating such a construct. We therefore planned a translation and validation study of the Nomophobia Questionnaire (NMP-Q), which is an instrument developed by Yildirim and Correia. Subjects were recruited via an online survey using a snowball approach. Methods The NMP-Q was translated from English into Italian using a classical “backwards and forwards” procedure. In order to explore the underlying factor structure of the translated questionnaire, an exploratory factor analysis was carried out. A principal component analysis approach with varimax rotation was performed. Multivariate regression analyses were computed to shed light on the psychological predictors of nomophobia. Results A sample of 403 subjects volunteered to take part in the study. The average age of participants was 27.91 years (standard deviation 8.63) and the sample was comprised of 160 males (160/403, 39.7%) and 243 females (243/403, 60.3%). Forty-five subjects spent less than 1 hour on their mobile phone per day (45/403, 11.2%), 94 spent between 1 and 2 hours (94/403, 23.3%), 69 spent between 2 and 3 hours (69/403, 17.1%), 58 spent between 3 and 4 hours (58/403, 14.4%), 48 spent between 4 and 5 hours (48/403, 11.9%), 29 spent between 5 and 7 hours (29/403, 7.2%), 36 spent between 7 and 9 hours (36/403, 8.9%), and 24 spent more than 10 hours (24/403, 6.0%). The eigenvalues and scree plot supported a 3-factorial nature of the translated questionnaire. The NMP-Q showed an overall Cronbach alpha coefficient of 0.95 (0.94, 0.89, and 0.88 for the three factors). The first factor explained up to 23.32% of the total variance, while the second and third factors explained up to 23.91% and 18.67% of the variance, respectively. The total NMP-Q score correlated with the number of hours spent on a mobile phone. Conclusions The Italian version of the NMP-Q proved to be reliable. PMID:29358161

Horizon: A Proposal for Large Aperture, Active Optics in Geosynchronous Orbit

NASA Technical Reports Server (NTRS)

Chesters, Dennis; Jenstrom, Del

2000-01-01

In 1999, NASA's New Millennium Program called for proposals to validate new technology in high-earth orbit for the Earth Observing-3 (NMP EO3) mission to fly in 2003. In response, we proposed to test a large aperture, active optics telescope in geosynchronous orbit. This would flight-qualify new technologies for both Earth and Space science: 1) a future instrument with LANDSAT image resolution and radiometric quality watching continuously from geosynchronous station, and 2) the Next Generation Space Telescope (NGST) for deep space imaging. Six enabling technologies were to be flight-qualified: 1) a 3-meter, lightweight segmented primary mirror, 2) mirror actuators and mechanisms, 3) a deformable mirror, 4) coarse phasing techniques, 5) phase retrieval for wavefront control during stellar viewing, and 6) phase diversity for wavefront control during Earth viewing. Three enhancing technologies were to be flight- validated: 1) mirror deployment and latching mechanisms, 2) an advanced microcontroller, and 3) GPS at GEO. In particular, two wavefront sensing algorithms, phase retrieval by JPL and phase diversity by ERIM International, were to sense optical system alignment and focus errors, and to correct them using high-precision mirror mechanisms. Active corrections based on Earth scenes are challenging because phase diversity images must be collected from extended, dynamically changing scenes. In addition, an Earth-facing telescope in GEO orbit is subject to a powerful diurnal thermal and radiometric cycle not experienced by deep-space astronomy. The Horizon proposal was a bare-bones design for a lightweight large-aperture, active optical system that is a practical blend of science requirements, emerging technologies, budget constraints, launch vehicle considerations, orbital mechanics, optical hardware, phase-determination algorithms, communication strategy, computational burdens, and first-rate cooperation among earth and space scientists, engineers and managers. This manuscript presents excerpts from the Horizon proposal's sections that describe the Earth science requirements, the structural -thermal-optical design, the wavefront sensing and control, and the on-orbit validation.

Earth Observing-1 Advanced Land Imager: Radiometric Response Calibration

NASA Technical Reports Server (NTRS)

Mendenhall, J. A.; Lencioni, D. E.; Evans, J. B.

2000-01-01

The Advanced Land Imager (ALI) is one of three instruments to be flown on the first Earth Observing mission (EO-1) under NASA's New Millennium Program (NMP). ALI contains a number of innovative features, including a wide field of view optical design, compact multispectral focal plane arrays, non-cryogenic HgCdTe detectors for the short wave infrared bands, and silicon carbide optics. This document outlines the techniques adopted during ground calibration of the radiometric response of the Advanced Land Imager. Results from system level measurements of the instrument response, signal-to-noise ratio, saturation radiance, and dynamic range for all detectors of every spectral band are also presented.

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

A new Postdoctoral Fellow position is immediately available in the laboratory of Dr. Terry Yamaguchi at the National Cancer Institute. Dr.Yamaguchi's lab investigates how secreted growth factors regulate the gene regulatory networks that control the fate of embryonic and adult stem cells. Current projects focus on understanding how Wnts and Fgfs regulate the formation and differentiation of the neuromesodermal progenitor (NMP), a multipotent embryonic cell that generates the spinal cord neurons and musculoskeletal system of the body. Using a combination of mouse genetics, mouse and human embryonic stem cell in vitro differentiation, and genomic, proteomic and biochemical approaches, Dr. Yamaguchi’s lab is investigating the molecular mechanisms underlying the activity of key transcriptional determinants of NMP development.

Pre-Launch End-to-End Testing Plans for the SPAce Readiness Coherent Lidar Experiment (SPARCLE)

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.

1999-01-01

The SPAce Readiness Coherent Lidar Experiment (SPARCLE) mission was proposed as a low cost technology demonstration mission, using a 2-micron, 100-mJ, 6-Hz, 25-cm, coherent lidar system based on demonstrated technology. SPARCLE was selected in late October 1997 to be NASA's New Millennium Program (NMP) second earth-observing (EO-2) mission. To maximize the success probability of SPARCLE, NASA/MSFC desired expert guidance in the areas of coherent laser radar (CLR) theory, CLR wind measurement, fielding of CLR systems, CLR alignment validation, and space lidar experience. This led to the formation of the NASA/MSFC Coherent Lidar Technology Advisory Team (CLTAT) in December 1997. A threefold purpose for the advisory team was identified as: 1) guidance to the SPARCLE mission, 2) advice regarding the roadmap of post-SPARCLE coherent Doppler wind lidar (CDWL) space missions and the desired matching technology development plan 3, and 3) general coherent lidar theory, simulation, hardware, and experiment information exchange. The current membership of the CLTAT is shown. Membership does not result in any NASA or other funding at this time. We envision the business of the CLTAT to be conducted mostly by email, teleconference, and occasional meetings. The three meetings of the CLTAT to date, in Jan. 1998, July 1998, and Jan. 1999, have all been collocated with previously scheduled meetings of the Working Group on Space-Based Lidar Winds. The meetings have been very productive. Topics discussed include the SPARCLE technology validation plan including pre-launch end-to-end testing, the space-based wind mission roadmap beyond SPARCLE and its implications on the resultant technology development, the current values and proposed future advancement in lidar system efficiency, and the difference between using single-mode fiber optical mixing vs. the traditional free space optical mixing. attitude information from lidar and non-lidar sensors, and pointing knowledge algorithms will meet this second requirement. The topic of this paper is the pre-launch demonstration of the first requirement, adequate sensitivity of the SPARCLE lidar.

Timekeeping for the Space Technology 5 (ST-5) Mission

NASA Technical Reports Server (NTRS)

Raphael, Dave; Luers, Phil; Sank, Victor; Jackson, George

2002-01-01

Space Technology 5, or better known as ST-5, is a space technology development mission in the New Millennium Program (NMP) and NASA s first experiment in the design of miniaturized satellite constellations. The mission will design, integrate and launch multiple spacecraft into an orbit high above the Earth s protective magnetic field known as the magnetosphere. Each spacecraft incorporates innovative technology and constellation concepts which will be instrumental in future space science missions. A total of three ST-5 spacecraft will be launched as secondary payloads into a highly elliptical geo-synchronous transfer orbit, and will operate as a 3-element constellation for a minimum duration of 90 days. In order to correlate the time of science measurements with orbit position relative to the Earth, orbit position in space (with respect to other objects in space) and/or with events measured on Earth or other spacecraft, accurate knowledge of spacecraft and ground time is needed. Ground time as used in the USA (known as Universal Time Coordinated or UTC) is maintained by the U.S. Naval Observatory. Spacecraft time is maintained onboard within the Command and Data Handling (C&DH) system. The science requirements for ST-5 are that spacecraft time and ground time be correlatable to each other, with some degree of accuracy. Accurate knowledge of UTC time on a spacecraft is required so that science measurements can be correlated with orbit position relative to the Earth, orbit position in space and with events measured on Earth or other spacecraft. The most crucial parameter is not the clock oscillator frequency, but more importantly, how the clock oscillator frequency varies with time or temperature (clock oscillator drift). Even with an incorrect clock oscillator frequency, if there were no drift, the frequency could be assessed by comparing the spacecraft clock to a ground clock during a few correlation events. Once the frequency is accurately known, it is easy enough to make a regular adjustment to the spacecraft clock or to calculate the correct ground time for a given spacecraft clock time. The oscillator frequency, however, is temperature dependent, drifts with age and is affected by radiation; hence, repeated correlation measurements are required.

Amide-induced phase separation of hexafluoroisopropanol-water mixtures depending on the hydrophobicity of amides.

PubMed

Takamuku, Toshiyuki; Wada, Hiroshi; Kawatoko, Chiemi; Shimomura, Takuya; Kanzaki, Ryo; Takeuchi, Munetaka

2012-06-21

Amide-induced phase separation of hexafluoro-2-propanol (HFIP)-water mixtures has been investigated to elucidate solvation properties of the mixtures by means of small-angle neutron scattering (SANS), (1)H and (13)C NMR, and molecular dynamics (MD) simulation. The amides included N-methylformamide (NMF), N-methylacetamide (NMA), and N-methylpropionamide (NMP). The phase diagrams of amide-HFIP-water ternary systems at 298 K showed that phase separation occurs in a closed-loop area of compositions as well as an N,N-dimethylformamide (DMF) system previously reported. The phase separation area becomes wider as the hydrophobicity of amides increases in the order of NMF < NMA < DMF < NMP. Thus, the evolution of HFIP clusters around amides due to the hydrophobic interaction gives rise to phase separation of the mixtures. In contrast, the disruption of HFIP clusters causes the recovery of the homogeneity of the ternary systems. The present results showed that HFIP clusters are evolved with increasing amide content to the lower phase separation concentration in the same mechanism among the four amide systems. However, the disruption of HFIP clusters in the NMP and DMF systems with further increasing amide content to the upper phase separation concentration occurs in a different way from those in the NMF and NMA systems.

Interpreting lateral dynamic weight shifts using a simple inverted pendulum model.

PubMed

Kennedy, Michael W; Bretl, Timothy; Schmiedeler, James P

2014-01-01

Seventy-five young, healthy adults completed a lateral weight-shifting activity in which each shifted his/her center of pressure (CoP) to visually displayed target locations with the aid of visual CoP feedback. Each subject's CoP data were modeled using a single-link inverted pendulum system with a spring-damper at the joint. This extends the simple inverted pendulum model of static balance in the sagittal plane to lateral weight-shifting balance. The model controlled pendulum angle using PD control and a ramp setpoint trajectory, and weight-shifting was characterized by both shift speed and a non-minimum phase (NMP) behavior metric. This NMP behavior metric examines the force magnitude at shift initiation and provides weight-shifting balance performance information that parallels the examination of peak ground reaction forces in gait analysis. Control parameters were optimized on a subject-by-subject basis to match balance metrics for modeled results to metric values calculated from experimental data. Overall, the model matches experimental data well (average percent error of 0.35% for shifting speed and 0.05% for NMP behavior). These results suggest that the single-link inverted pendulum model can be used effectively to capture lateral weight-shifting balance, as it has been shown to model static balance. Copyright © 2014 Elsevier B.V. All rights reserved.

Quantification of four major metabolites of embryotoxic N-methyl- and N-ethyl-2-pyrrolidone in human urine by cooled-injection gas chromatography and isotope dilution mass spectrometry.

PubMed

Schindler, Birgit K; Koslitz, Stephan; Meier, Swetlana; Belov, Vladimir N; Koch, Holger M; Weiss, Tobias; Brüning, Thomas; Käfferlein, Heiko U

2012-04-17

N-Methyl- and N-ethyl-2-pyrollidone (NMP and NEP) are frequently used industrial solvents and were shown to be embryotoxic in animal experiments. We developed a sensitive, specific, and robust analytical method based on cooled-injection (CIS) gas chromatography and isotope dilution mass spectrometry to analyze 5-hydroxy-N-ethyl-2-pyrrolidone (5-HNEP) and 2-hydroxy-N-ethylsuccinimide (2-HESI), two newly identified presumed metabolites of NEP, and their corresponding methyl counterparts (5-HNMP, 2-HMSI) in human urine. The urine was spiked with deuterium-labeled analogues of these metabolites. The analytes were separated from urinary matrix by solid-phase extraction and silylated prior to quantification. Validation of this method was carried out by using both, spiked pooled urine samples and urine samples from 56 individuals of the general population with no known occupational exposure to NMP and NEP. Interday and intraday imprecision was better than 8% for all metabolites, while the limits of detection were between 5 and 20 μg/L depending on the analyte. The high sensitivity of the method enables us to quantify NMP and NEP metabolites at current environmental exposures by human biomonitoring.

A microfluidic device with multi-valves system to enable several simultaneous exposure tests on Caenorhabditis elegans

NASA Astrophysics Data System (ADS)

Jung, Jaehoon; Nakajima, Masahiro; Masaru, Takeuchi; Huang, Qiang; Fukuda, Toshio

2014-03-01

In this paper, we report on a microfluidic device with a multi-valve system to conduct several exposure tests on Caenorhabditis elegans (C. elegans) simultaneously. It has pneumatic valves and no-moving-parts (NMP) valves. An NMP valve is incorporated with a chamber and enables the unidirectional movement of C. elegans in the chamber; once worms are loaded into the chamber, they cannot exit, regardless of the flow direction. To demonstrate the ability of the NMP valve to handle worms, we made a microfluidic device with three chambers. Each chamber was used to expose worms to Cd and Cu solutions, and K-medium. A pair of electrodes was installed in the device and the capacitance in-between the electrode was measured. When a C. elegans passed through the electrodes, the capacitance was changed. The capacitance change was proportional to the body volume of the worm, thus the body volume change by the heavy metal exposure was measured in the device. Thirty worms were divided into three groups and exposed to each solution. We confirmed that the different solutions induced differences in the capacitance changes for each group. These results indicate that our device is a viable method for simultaneously analyzing the effect of multiple stimuli on C. elegans.

A novel dimerization interface of cyclic nucleotide binding domain, which is disrupted in presence of cAMP: implications for CNG channels gating.

PubMed

Gushchin, Ivan Y; Gordeliy, Valentin I; Grudinin, Sergei

2012-09-01

Cyclic nucleotide binding domain (CNBD) is a ubiquitous domain of effector proteins involved in signalling cascades of prokaryota and eukaryota. CNBD activation by cyclic nucleotide monophosphate (cNMP) is studied well in the case of several proteins. However, this knowledge is hardly applicable to cNMP-modulated cation channels. Despite the availability of CNBD crystal structures of bacterial cyclic nucleotide-gated (CNG) and mammalian hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels in presence and absence of the cNMP, the full understanding of CNBD conformational changes during activation is lacking. Here, we describe a novel CNBD dimerization interface found in crystal structures of bacterial CNG channel MlotiK1 and mammalian cAMP-activated guanine nucleotide-exchange factor Epac2. Molecular dynamics simulations show that the found interface is stable on the studied timescale of 100 ns, in contrast to the dimerization interface, reported previously. Comparisons with cN-bound structures of CNBD show that the dimerization is incompatible with cAMP binding. Thus, the cAMP-dependent monomerization of CNBD may be an alternative mechanism of the cAMP sensing. Based on these findings, we propose a model of the bacterial CNG channel modulation by cAMP.

Translation and Validation of the Nomophobia Questionnaire in the Italian Language: Exploratory Factor Analysis.

PubMed

Adawi, Mohammad; Bragazzi, Nicola Luigi; Argumosa-Villar, Lidia; Boada-Grau, Joan; Vigil-Colet, Andreu; Yildirim, Caglar; Del Puente, Giovanni; Watad, Abdulla

2018-01-22

Nomophobia, which is a neologism derived from the combination of "no mobile," "phone," and "phobia" is considered to be a modern situational phobia and indicates a fear of feeling disconnected. No psychometric scales are available in Italian for investigating such a construct. We therefore planned a translation and validation study of the Nomophobia Questionnaire (NMP-Q), which is an instrument developed by Yildirim and Correia. Subjects were recruited via an online survey using a snowball approach. The NMP-Q was translated from English into Italian using a classical "backwards and forwards" procedure. In order to explore the underlying factor structure of the translated questionnaire, an exploratory factor analysis was carried out. A principal component analysis approach with varimax rotation was performed. Multivariate regression analyses were computed to shed light on the psychological predictors of nomophobia. A sample of 403 subjects volunteered to take part in the study. The average age of participants was 27.91 years (standard deviation 8.63) and the sample was comprised of 160 males (160/403, 39.7%) and 243 females (243/403, 60.3%). Forty-five subjects spent less than 1 hour on their mobile phone per day (45/403, 11.2%), 94 spent between 1 and 2 hours (94/403, 23.3%), 69 spent between 2 and 3 hours (69/403, 17.1%), 58 spent between 3 and 4 hours (58/403, 14.4%), 48 spent between 4 and 5 hours (48/403, 11.9%), 29 spent between 5 and 7 hours (29/403, 7.2%), 36 spent between 7 and 9 hours (36/403, 8.9%), and 24 spent more than 10 hours (24/403, 6.0%). The eigenvalues and scree plot supported a 3-factorial nature of the translated questionnaire. The NMP-Q showed an overall Cronbach alpha coefficient of 0.95 (0.94, 0.89, and 0.88 for the three factors). The first factor explained up to 23.32% of the total variance, while the second and third factors explained up to 23.91% and 18.67% of the variance, respectively. The total NMP-Q score correlated with the number of hours spent on a mobile phone. The Italian version of the NMP-Q proved to be reliable. ©Mohammad Adawi, Nicola Luigi Bragazzi, Lidia Argumosa-Villar, Joan Boada-Grau, Andreu Vigil-Colet, Caglar Yildirim, Giovanni Del Puente, Abdulla Watad. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 22.01.2018.

Thermal and Mechanical Performance of a Carbon/Carbon Composite Spacecraft Radiator

NASA Technical Reports Server (NTRS)

Kuhn, Jonathan; Benner, Steve; Butler, Dan; Silk, Eric

1999-01-01

Carbon-carbon composite materials offer greater thermal efficiency, stiffness to weight ratio, tailorability, and dimensional stability than aluminum. These lightweight thermal materials could significantly reduce the overall costs associated with satellite thermal control and weight. However, the high cost and long lead-time for carbon-carbon manufacture have limited their widespread usage. Consequently, an informal partnership between government and industrial personnel called the Carbon-Carbon Spacecraft Radiator Partnership (CSRP) was created to foster carbon-carbon composite use for thermally and structurally demanding space radiator applications. The first CSRP flight opportunity is on the New Millennium Program (NMP) Earth Orbiter-1 (EO-1) spacecraft, scheduled for launch in late 1999. For EO-1, the CSRP designed and fabricated a Carbon-Carbon Radiator (CCR) with carbon-carbon facesheets and aluminum honeycomb core, which will also serve as a structural shear panel. While carbon-carbon is an ideal thermal candidate for spacecraft radiators, in practice there are technical challenges that may compromise performance. In this work, the thermal and mechanical performance of the EO-1 CCR is assessed by analysis and testing. Both then-nal and mechanical analyses were conducted to predict the radiator response to anticipated launch and on-orbit loads. The thermal model developed was based on thermal balance test conditions. The thermal analysis was performed using SINDA version 4.0. Structural finite element modeling and analysis were performed using SDRC/1-DEAS and UAI/NASTRAN, respectively. In addition, the CCR was subjected to flight qualification thermal/vacuum and vibration tests. The panel meets or exceeds the requirements for space flight and demonstrates promise for future satellite missions.

EO-1 analysis applicable to coastal characterization

NASA Astrophysics Data System (ADS)

Burke, Hsiao-hua K.; Misra, Bijoy; Hsu, Su May; Griffin, Michael K.; Upham, Carolyn; Farrar, Kris

2003-09-01

The EO-1 satellite is part of NASA's New Millennium Program (NMP). It consists of three imaging sensors: the multi-spectral Advanced Land Imager (ALI), Hyperion and Atmospheric Corrector. Hyperion provides a high-resolution hyperspectral imager capable of resolving 220 spectral bands (from 0.4 to 2.5 micron) with a 30 m resolution. The instrument images a 7.5 km by 100 km land area per image. Hyperion is currently the only space-borne HSI data source since the launch of EO-1 in late 2000. The discussion begins with the unique capability of hyperspectral sensing to coastal characterization: (1) most ocean feature algorithms are semi-empirical retrievals and HSI has all spectral bands to provide legacy with previous sensors and to explore new information, (2) coastal features are more complex than those of deep ocean that coupled effects are best resolved with HSI, and (3) with contiguous spectral coverage, atmospheric compensation can be done with more accuracy and confidence, especially since atmospheric aerosol effects are the most pronounced in the visible region where coastal feature lie. EO-1 data from Chesapeake Bay from 19 February 2002 are analyzed. In this presentation, it is first illustrated that hyperspectral data inherently provide more information for feature extraction than multispectral data despite Hyperion has lower SNR than ALI. Chlorophyll retrievals are also shown. The results compare favorably with data from other sources. The analysis illustrates the potential value of Hyperion (and HSI in general) data to coastal characterization. Future measurement requirements (air borne and space borne) are also discussed.

Genetic locus (nmp-1) affecting the principal outer membrane protein of Neisseria gonorrhoeae.

PubMed Central

Cannon, J G; Klapper, D G; Blackman, E Y; Sparling, P F

1980-01-01

An increase in the apparent molecular weight of the principal outer membrane protein (POMP) of Neisseria gonorrhoeae is associated with introduction of the penB2 genetic marker, which results in low-level, relatively nonspecific antibiotic resistance. Limited proteolysis of the two forms of POMP showed that they had few if any peptides in common. The nonspecific antibiotic resistance of penB2 was separated from the change in POMP by genetic transformation and by isolation of spontaneous penB mutants that showed no change in POMP. The genetic locus involved in the change from one POMP to another, which we have designated nmp-1, is closely linked to, but not identical with, penB2. Images PMID:6782080

"We can see a future here": Place attachment, professional identity, and forms of capital mobilized to deliver medical education in an underserviced area.

PubMed

Hanlon, Neil; Halseth, Greg; Snadden, David

2010-09-01

Community-integrated undergraduate medical education is becoming a more common option for students predisposed to practice in rural and small town places. One such initiative, the Northern Medical Program, has been operating since 2004 in the northern interior of British Columbia, Canada. The NMP's curriculum relies heavily on the involvement of practicing physicians in its host community, Prince George. Drawing on Bourdieu's conceptualization of capital in its different forms, the commitment of the local physician community is understood as social capital derived from cultural capital centred on a collective sense of professional identity forged by conditions of practice in an underserviced area. The findings of this study are discussed with respect to the long-term operation and success of community-integrated medical education programs. Copyright 2010 Elsevier Ltd. All rights reserved.

The Psychometric Properties of the Smartphone Application-Based Addiction Scale (SABAS).

PubMed

Csibi, Sándor; Griffiths, Mark D; Cook, Brian; Demetrovics, Zsolt; Szabo, Attila

2018-01-01

The goal of the study was to validate the English version of the Smartphone Application-Based Addiction Scale (SABAS; Csibi et al. 2016), which is a short and easy-to-use tool for screening the risk of smartphone application-based addiction. Another aim was to identify the most frequently used smartphone applications and their perceived importance by the participants. Data were collected online from 240 English-speaking volunteers, aged 18 to 69 years. The instruments used were the SABAS, the Nomophobia Questionnaire (NMP-Q), the Brief Sensation Seeking Scale (BSSS), the Deprivation Sensation Scale (DSS), and the Patient Health Questionnaire (PHQ-9). Participants also ranked the importance of their most frequently used smartphone applications. The six items of the SABAS yielded one component, which accounted for 52.38% of the total variance. The internal reliability of the scale was good (Cronbach's alpha 0.81). NMP-Q was a significant predictor of SABAS, explaining 17.6% of the total variance. The regression analysis, with SABAS score as the dependent variable and NMP-Q, DSS, PHQ-9, and BSSS scores as predictors, indicated that approximately 47% of the variance in SABAS was accounted for by the predictors ( R 2  = 0.47). The English version of the SABAS appears to be a valid and reliable ultra-brief tool for a quick and easy assessment of smartphone application-based addiction symptoms.

Perfluoro anion based binary and ternary ionic liquids as electrolytes for dye-sensitized solar cells

NASA Astrophysics Data System (ADS)

Lin, Hsi-Hsin; Peng, Jia-De; Suryanarayanan, V.; Velayutham, D.; Ho, Kuo-Chuan

2016-04-01

In this work, eight new ionic liquids (ILs) based on triethylammonium (TEA) or n-methylpiperidinium (NMP) cations and perfluoro carboxylate (PFC) anions having different carbon chain lengths are synthesized and their physico-chemical properties such as density, decomposition temperature, viscosity and conductivity are determined. Photovoltaic characteristics of dye-sensitized solar cells (DSSCs) with binary ionic liquids electrolytes, containing the mixture of the synthesized ILs and 1-methyl-3-propyl imidazolium iodide (PMII) (v/v = 35/65), are evaluated. Among the different ILs, solar cells containing NMP based ILs show higher VOC than that of TEA, whereas, higher JSC is noted for the DSSCs incorporated with the latter when compared to the former. Further, the photo-current of the DSSCs decreases with the increase of the carbon chain length of perfluoro carboxylate anionic group of ILs. The cell performance of the DSSC containing ternary ionic liquids-based electrolytes compose of NMP-2C/TEA-2C/PMII (v/v/v = 28/7/65) exhibits a JSC of 12.99 mA cm-2, a VOC of 639.0 mV, a FF of 0.72, and a cell efficiency of 6.01%. The extraordinary durability of the DSSC containing the above combination of electrolytes stored in dark at 50 °C is proved to be unfailing up to 1200 h.

Influence of the Ionic Liquid Type on the Gel Polymer Electrolytes Properties

PubMed Central

Tafur, Juan P.; Santos, Florencio; Fernández Romero, Antonio J.

2015-01-01

Gel Polymer Electrolytes (GPEs) composed by ZnTf2 salt, poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP), and different ionic liquids are synthesized using n-methyl-2-pyrrolidone (NMP) as solvent. Three different imidazolium-based ionic liquids containing diverse cations and anions have been explored. Structural and electrical properties of the GPEs varying the ZnTf2 concentration are analyzed by ATR-FTIR, DSC, TG, and cyclic voltammetry. Free salt IL-GPEs present distinct behavior because they are influenced by the different IL cations and anions composition. However, inclusion of ZnTf2 salt inside the polymers provide GPEs with very similar characteristics, pointing out that ionic transport properties are principally caused by Zn2+ and triflate movement. Whatever the IL used, the presence of NMP solvent inside the polymer’s matrix turns out to be a key factor for improving the Zn2+ transport inside the GPE due to the interaction between Zn2+ cations and carbonyl groups of the NMP. High values of ionic conductivity, low activation energy values, and good voltammetric reversibility obtained regardless of the ionic liquid used enable these GPEs to be applied in Zn batteries. Capacities of 110–120 mAh·g−1 have been obtained for Zn/IL-GPE/MnO2 batteries discharged at −1 mA·cm−2. PMID:26610580

Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation.

PubMed

Mergental, H; Perera, M T P R; Laing, R W; Muiesan, P; Isaac, J R; Smith, A; Stephenson, B T F; Cilliers, H; Neil, D A H; Hübscher, S G; Afford, S C; Mirza, D F

2016-11-01

The demand for liver transplantation (LT) exceeds supply, with rising waiting list mortality. Utilization of high-risk organs is low and a substantial number of procured livers are discarded. We report the first series of five transplants with rejected livers following viability assessment by normothermic machine perfusion of the liver (NMP-L). The evaluation protocol consisted of perfusate lactate, bile production, vascular flows, and liver appearance. All livers were exposed to a variable period of static cold storage prior to commencing NMP-L. Four organs were recovered from donors after circulatory death and rejected due to prolonged donor warm ischemic times; one liver from a brain-death donor was declined for high liver function tests (LFTs). The median (range) total graft preservation time was 798 (range 724-951) min. The transplant procedure was uneventful in every recipient, with immediate function in all grafts. The median in-hospital stay was 10 (range 6-14) days. At present, all recipients are well, with normalized LFTs at median follow-up of 7 (range 6-19) months. Viability assessment of high-risk grafts using NMP-L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction. This novel approach may increase organ availability for LT. © Copyright 2016 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons.

Selenium quantum dots: Preparation, structure, and properties

NASA Astrophysics Data System (ADS)

Qian, Fuli; Li, Xueming; Tang, Libin; Lai, Sin Ki; Lu, Chaoyu; Lau, Shu Ping

2017-01-01

An interesting class of low-dimensional nanomaterials, namely, selenium quantum dots (SeQDs), which are composed of nano-sized selenium particles, is reported in this study. The SeQDs possess a hexagonal crystal structure. They can be synthesized in large quantity by ultrasound liquid-phase exfoliation using NbSe2 powders as the source material and N-Methyl-2-pyrrolidone (NMP) as the dispersant. During sonication, the Nb-Se bonds dissociate; the SeQDs are formed, while niobium is separated by centrifugation. The SeQDs have a narrow diameter distribution from 1.9 to 4.6 nm and can be dispersed with high stability in NMP without the need for passivating agents. They exhibit photoluminescence properties that are expected to find useful applications in bioimaging, optoelectronics, as well as nanocomposites.

Agent Based Software for the Autonomous Control of Formation Flying Spacecraft

NASA Technical Reports Server (NTRS)

How, Jonathan P.; Campbell, Mark; Dennehy, Neil (Technical Monitor)

2003-01-01

Distributed satellite systems is an enabling technology for many future NASA/DoD earth and space science missions, such as MMS, MAXIM, Leonardo, and LISA [1, 2, 3]. While formation flying offers significant science benefits, to reduce the operating costs for these missions it will be essential that these multiple vehicles effectively act as a single spacecraft by performing coordinated observations. Autonomous guidance, navigation, and control as part of a coordinated fleet-autonomy is a key technology that will help accomplish this complex goal. This is no small task, as most current space missions require significant input from the ground for even relatively simple decisions such as thruster burns. Work for the NMP DS1 mission focused on the development of the New Millennium Remote Agent (NMRA) architecture for autonomous spacecraft control systems. NMRA integrates traditional real-time monitoring and control with components for constraint-based planning, robust multi-threaded execution, and model-based diagnosis and reconfiguration. The complexity of using an autonomous approach for space flight software was evident when most of its capabilities were stripped off prior to launch (although more capability was uplinked subsequently, and the resulting demonstration was very successful).

Interconversion of Functional Motions between Mesophilic and Thermophilic Adenylate Kinases

PubMed Central

Daily, Michael D.; Phillips, George N.; Cui, Qiang

2011-01-01

Dynamic properties are functionally important in many proteins, including the enzyme adenylate kinase (AK), for which the open/closed transition limits the rate of catalytic turnover. Here, we compare our previously published coarse-grained (double-well Gō) simulation of mesophilic AK from E. coli (AKmeso) to simulations of thermophilic AK from Aquifex aeolicus (AKthermo). In AKthermo, as with AKmeso, the LID domain prefers to close before the NMP domain in the presence of ligand, but LID rigid-body flexibility in the open (O) ensemble decreases significantly. Backbone foldedness in O and/or transition state (TS) ensembles increases significantly relative to AKmeso in some interdomain backbone hinges and within LID. In contact space, the TS of AKthermo has fewer contacts at the CORE-LID interface but a stronger contact network surrounding the CORE-NMP interface than the TS of AKmeso. A “heated” simulation of AKthermo at 375K slightly increases LID rigid-body flexibility in accordance with the “corresponding states” hypothesis. Furthermore, while computational mutation of 7 prolines in AKthermo to their AKmeso counterparts produces similar small perturbations, mutation of these sites, especially positions 8 and 155, to glycine is required to achieve LID rigid-body flexibility and hinge flexibilities comparable to AKmeso. Mutating the 7 sites to proline in AKmeso reduces some hinges' flexibilities, especially hinge 2, but does not reduce LID rigid-body flexibility, suggesting that these two types of motion are decoupled in AKmeso. In conclusion, our results suggest that hinge flexibility and global functional motions alike are correlated with but not exclusively determined by the hinge residues. This mutational framework can inform the rational design of functionally important flexibility and allostery in other proteins toward engineering novel biochemical pathways. PMID:21779157

An overiew of non medical prescribing across one strategic health authority: a questionnaire survey.

PubMed

Courtenay, Molly; Carey, Nicola; Stenner, Karen

2012-06-01

Over 50,000 non-medical healthcare professionals across the United Kingdom now have prescribing capabilities. However, there is no evidence available with regards to the extent to which non-medical prescribing (NMP) has been implemented within organisations across a strategic health authority (SHA). The aim of the study was to provide an overview of NMP across one SHA. NMP leads across one SHA were asked to supply the email addresses of NMPs within their organisation. One thousand five hundred and eighty five NMPs were contacted and invited to complete an on-line descriptive questionnaire survey, 883 (55.7%) participants responded. Data was collected between November 2010 and February 2011. The majority of NMPs were based in primary care and worked in a team of 2 or more. Nurse independent supplementary prescribers were the largest group (590 or 68.6%) compared to community practitioner prescribers (198 or 22.4%), pharmacist independent supplementary prescribers (35 or 4%), and allied health professionals and optometrist independent and/or supplementary prescribers (8 or 0.9%). Nearly all (over 90%) of nurse independent supplementary prescribers prescribed medicines. Approximately a third of pharmacist independent supplementary prescribers, allied health professionals, and community practitioner prescribers did not prescribe. Clinical governance procedures were largely in place, although fewer procedures were reported by community practitioner prescribers. General practice nurses prescribed the most items. Factors affecting prescribing practice were: employer, the level of experience prior to becoming a non-medical prescriber, existence of governance procedures and support for the prescribing role (p < 0.001). NMP in this strategic health authority reflects national development of this relatively new role in that the majority of non-medical prescribers were nurses based in primary care, with fewer pharmacist and allied health professional prescribers. This workforce is contributing to medicines management activities in a range of care settings. If non-medical prescibers are to maximise their contribution, robust governance and support from healthcare organisations is essential. The continued use of supplementary prescribing is questionable if maximum efficiency is sought. These are important points that need to be considered by those responsible for developing non-medical prescribing in the United Kingdom and other countries around the world.

Navy Operational Planner

DTIC Science & Technology

2015-03-01

wine warfare NCC naval component commander NFC numbered fleet commander NM nautical mile NMP Navy mission planner NOP Navy...principles for naval component commanders ( NCCs ), numbered fleet commanders (NFCs) or joint force maritime component commanders (JFMCCs) and their

Self-assembly of a tetrahedral 58-nuclear barium vanadium oxide cluster.

PubMed

Kastner, Katharina; Puscher, Bianka; Streb, Carsten

2013-01-07

We report the synthesis and characterization of a molecular barium vanadium oxide cluster featuring high nuclearity and high symmetry. The tetrameric, 2.3 nm cluster H(5)[Ba(10)(NMP)(14)(H(2)O)(8)[V(12)O(33)](4)Br] is based on a bromide-centred, octahedral barium scaffold which is capped by four previously unknown [V(12)O(33)](6-) clusters in a tetrahedral fashion. The compound represents the largest polyoxovanadate-based heterometallic cluster known to date. The cluster is formed in organic solution and it is suggested that the bulky N-methyl-2-pyrrolidone (NMP) solvent ligands allow the isolation of this giant molecule and prevent further condensation to a solid-state metal oxide. The cluster is fully characterized using single-crystal XRD, elemental analysis, ESI mass spectrometry and other spectroscopic techniques.

Acetone improves the topographical homogeneity of liquid phase exfoliated few-layer black phosphorus flakes.

PubMed

Gomez Perez, Juan; Konya, Zoltan; Kukovecz, Akos

2018-06-12

Liquid phase exfoliation of 2D materials has issues related to the sorption of the solvent, the oxidation of the sample during storage, and the topographical inhomogeneity of the exfoliated material. N-methyl-2-pyrrolidone (NMP), a common solvent for black phosphorus (BP) exfoliation, has additional drawbacks like the formation of by-products during sonication and poor solvent volatility. Here we demonstrate an improvement in the topographical homogeneity (i.e. thickness and lateral dimensions) of NMP-exfoliated BP flakes after resuspension in acetone. The typical size of monolayers and bilayers stabilised in acetone was 99.8±27.4 nm and 159.1±57 nm, respectively. These standard deviations represent a threefold improvement over those of the NMP-exfoliated originals. Phosphorene can also be exfoliated directly in acetone by very long ultrasonication. The product suspension enjoys the same dimensional homogeneity benefits, which confirms that this effect is an intrinsic property of the acetone-BP system. The quality and stability of the exfoliated flakes was checked by XRD, TEM, electron diffraction and Raman spectroscopy. Thermal expansion coefficients of the A1g, B2g and A2g Raman modes were calculated for drop-casted samples as -0.01828 cm-1/K, -0.03056 cm-1/K and -0.03219 cm-1/K, respectively. The flakes withstand 20 minutes in O2 flow at 373 K without lattice distortion. . © 2018 IOP Publishing Ltd.

Mesenchymal Stromal Cells as Anti-Inflammatory and Regenerative Mediators for Donor Kidneys During Normothermic Machine Perfusion.

PubMed

Sierra-Parraga, Jesus Maria; Eijken, Marco; Hunter, James; Moers, Cyril; Leuvenink, Henri; Møller, Bjarne; Ploeg, Rutger J; Baan, Carla C; Jespersen, Bente; Hoogduijn, Martin J

2017-08-15

There is great demand for transplant kidneys for the treatment of end-stage kidney disease patients. To expand the donor pool, organs from older and comorbid brain death donors, so-called expanded criteria donors (ECD), as well as donation after circulatory death donors, are considered for transplantation. However, the quality of these organs may be inferior to standard donor organs. A major issue affecting graft function and survival is ischemia/reperfusion injury, which particularly affects kidneys from deceased donors. The development of hypothermic machine perfusion has been introduced in kidney transplantation as a preservation technique and has improved outcomes in ECD and marginal organs compared to static cold storage. Normothermic machine perfusion (NMP) is the most recent evolution of perfusion technology and allows assessment of the donor organ before transplantation. The possibility to control the content of the perfusion fluid offers opportunities for damage control and reparative therapies during machine perfusion. Mesenchymal stromal cells (MSC) have been demonstrated to possess potent regenerative properties via the release of paracrine effectors. The combination of NMP and MSC administration at the same time is a promising procedure in the field of transplantation. Therefore, the MePEP consortium has been created to study this novel modality of treatment in preparation for human trials. MePEP aims to assess the therapeutic effects of MSC administered ex vivo by NMP in the mechanisms of injury and repair in a porcine kidney autotransplantation model.

Characterization of Periplasmic Protein BP26 Epitopes of Brucella melitensis Reacting with Murine Monoclonal and Sheep Antibodies

PubMed Central

Wu, Jingbo; Zhang, Hui; Wang, Yuanzhi; Qiao, Jun; Chen, Chuangfu; Gao, Goege F.; Allain, Jean-Pierre; Li, Chengyao

2012-01-01

More than 35,000 new cases of human brucellosis were reported in 2010 by the Chinese Center for Disease Control and Prevention. An attenuated B. melitensis vaccine M5-90 is currently used for vaccination of sheep and goats in China. In the study, a periplasmic protein BP26 from M5-90 was characterized for its epitope reactivity with mouse monoclonal and sheep antibodies. A total of 29 monoclonal antibodies (mAbs) against recombinant BP26 (rBP26) were produced, which were tested for reactivity with a panel of BP26 peptides, three truncated rBP26 and native BP26 containing membrane protein extracts (NMP) of B. melitensis M5-90 in ELISA and Western-Blot. The linear, semi-conformational and conformational epitopes from native BP26 were identified. Two linear epitopes recognized by mAbs were revealed by 28 of 16mer overlapping peptides, which were accurately mapped as the core motif of amino acid residues 93DRDLQTGGI101 (position 93 to 101) or residues 104QPIYVYPD111, respectively. The reactivity of linear epitope peptides, rBP26 and NMP was tested with 137 sheep sera by ELISAs, of which the two linear epitopes had 65–70% reactivity and NMP 90% consistent with the results of a combination of two standard serological tests. The results were helpful for evaluating the reactivity of BP26 antigen in M5-90. PMID:22457830

Processing Robustness for A Phenylethynyl Terminated Polyimide Composite

NASA Technical Reports Server (NTRS)

Hou, Tan-Hung

2004-01-01

The processability of a phenylethynyl terminated imide resin matrix (designated as PETI-5) composite is investigated. Unidirectional prepregs are made by coating an N-methylpyrrolidone solution of the amide acid oligomer (designated as PETAA-5/NMP) onto unsized IM7 fibers. Two batches of prepregs are used: one is made by NASA in-house, and the other is from an industrial source. The composite processing robustness is investigated with respect to the prepreg shelf life, the effect of B-staging conditions, and the optimal processing window. Prepreg rheology and open hole compression (OHC) strengths are found not to be affected by prolonged (i.e., up to 60 days) ambient storage. Rheological measurements indicate that the PETAA-5/NMP processability is only slightly affected over a wide range of B-stage temperatures from 250 deg C to 300 deg C. The OHC strength values are statistically indistinguishable among laminates consolidated using various B-staging conditions. An optimal processing window is established by means of the response surface methodology. IM7/PETAA-5/NMP prepreg is more sensitive to consolidation temperature than to pressure. A good consolidation is achievable at 371 deg C (700 deg F)/100 Psi, which yields an RT OHC strength of 62 Ksi. However, processability declines dramatically at temperatures below 350 deg C (662 deg F), as evidenced by the OHC strength values. The processability of the IM7/LARC(TM) PETI-5 prepreg was found to be robust.

Summary of External Peer Review and Public Comments and Disposition

EPA Pesticide Factsheets

This document summarizes the public and external peer review comments that the EPA’s Office of Pollution Prevention and Toxics (OPPT) received for the draft work plan risk assessment for n-Methylpyrrolidone (NMP).

[Stability in association of the peripheral material with mitotic chromosomes].

PubMed

Kosykh, M I; Chentsov, Iu S

2002-01-01

The localization of nucleolar proteins (fibrillarin and B-23), and of the protein of interphase nuclear matrix (NMP-65) was studied in the perichromosomal material (CM) after of short hypotonic treatment (15% solution of Henks medium) on cultured pig embryonic kidney cells, followed by restoration of isotonic conditions. It is shown that during hypotonic shock the mitotic chromosomes demonstrate reversible swelling, but their periphery is bounded with a rim of PCM, containing antibodies to fibrillarin and NMP-65, but not to B-23. After returning the cells to the initial isotonic medium, all the three proteins can be detected again on the periphery of chromosomes. It suggests the existence of different stability in the association of free proteins with chromosome bodies. Besides, B-23 and fibrillarin could be visualized in residual nucleoli after a complete extraction of histones and DNA from nuclei.

Crystal structure of human nicotinamide riboside kinase.

PubMed

Khan, Javed A; Xiang, Song; Tong, Liang

2007-08-01

Nicotinamide riboside kinase (NRK) has an important role in the biosynthesis of NAD(+) as well as the activation of tiazofurin and other NR analogs for anticancer therapy. NRK belongs to the deoxynucleoside kinase and nucleoside monophosphate (NMP) kinase superfamily, although the degree of sequence conservation is very low. We report here the crystal structures of human NRK1 in a binary complex with the reaction product nicotinamide mononucleotide (NMN) at 1.5 A resolution and in a ternary complex with ADP and tiazofurin at 2.7 A resolution. The active site is located in a groove between the central parallel beta sheet core and the LID and NMP-binding domains. The hydroxyl groups on the ribose of NR are recognized by Asp56 and Arg129, and Asp36 is the general base of the enzyme. Mutation of residues in the active site can abolish the catalytic activity of the enzyme, confirming the structural observations.

Solvent engineering for high-quality perovskite solar cell with an efficiency approaching 20%

NASA Astrophysics Data System (ADS)

Wu, Tongyue; Wu, Jihuai; Tu, Yongguang; He, Xin; Lan, Zhang; Huang, Miaoliang; Lin, Jianming

2017-10-01

The perovskite layer is the most crucial factor for the high performance perovskite solar cells. Based on solvent engineering, we develop a ternary-mixed-solvent method for the growth of high-quality [Cs0.05(MA0.17FA0.83)0.95Pb(I0.83Br0.17)3] cation-anion-mixed perovskite films by introducing N-methyl-2-pyrrolidone (NMP) into the precursor mixed solution. By controlling rapid nucleation and retarding crystal growth via intermediate phase PbI2-NMP (Lewis acid-base adduct), a dense, large grain, pinhole-free and long charge carrier lifetime perovskite film is obtained. By optimizing the precursor solvent composition, the perovskite solar cell achieves an impressive power conversion efficiency of 19.61% under one-sun illumination. The research presented here provides a facile, low-cost and highly efficient way for the preparation of perovskite solar cells.

The pharmacokinetics of pyridostigmine and 3-hydroxy-N-methylpyridinium in the rat: dose-dependent effects after portal vein administration.

PubMed Central

Barber, H E; Bourne, G R; Calvey, T N; Muir, K T

1975-01-01

1 The elimination kinectis of [14C]-pyridostigmine iodine and [14-C-methyl]-3-hydroxypyridinium bromide (3-OH NMP) have been studied in the rat. 2 For pyridostigmine, at a given dose level, the fraction of the dose eliminated unchanged was reduced and the metabolite fraction was increased after portal vein administration when compared to jugular vein administration. This indicates that pyridostigmine is subject to metabolism during the first passage through the liver. 3 When doses of pyridostigmine 1.25 mumol/kg and higher were injected via the portal vein, the proportion excreted in urine as unchanged drug remained constant; in contrast, the percentage of the dose eliminated as the metabolite was significantly reduced. This indicates that a dose-dependent process is involved in the urinary excretion of 3-OH NMP. 4 This conclusion was supported by studies involving the portal and systemic venous injection of 3-OH NMP at different dose levels. After 4 h, approximately85% of the lowest dose was eliminated unchanged in ug this period. The proportion of the dose eliminated in urine was not related to the route of administration. 5 After the injection of pyridostigmine into the jugular vein, the initial rate of drug excretion fell rapidly for approximately 10 min; in contrast, after injection into the portal vein, the rate of excretion of the drug rose to a maximum at 30 minutes. This suggests that the hepatoportal system behaves as a distinct region during the distribution of this drug. PMID:173444

Laryngeal reinnervation featuring refined nerve-muscle pedicle implantation evaluated via electromyography and use of coronal images.

PubMed

Sanuki, Tetsuji; Yumoto, Eiji; Nishimoto, Kohei; Kodama, Narihiro; Kodama, Haruka; Minoda, Ryosei

2015-04-01

To evaluate the long-term efficacy of laryngeal reinnervation via refined nerve-muscle pedicle (NMP) flap implantation combined with arytenoid adduction to treat unilateral vocal fold paralysis (UVFP), employing laryngeal electromyography (LEMG), coronal imaging, and phonatory function assessment. Case series with chart review. University hospital. We retrospectively reviewed 12 UVFP patients who underwent refined NMP implantation with arytenoid adduction. Videostroboscopy, phonatory functional analysis, LEMG, and coronal imaging were performed before and 2 years after surgery. In LEMG analysis, a 4-point scale was employed to grade motor unit (MU) recruitment: 4+ reflected no recruitment, 3+ greatly decreased recruitment, 2+ moderately decreased recruitment, and 1+ mildly decreased activity, associated with less than the full interference pattern. Coronal images were assessed in terms of differences in thickness and the vertical positions of the vocal folds. Phonatory function improved significantly after operation in all patients. In terms of LEMG findings, the preoperative MU recruitment scores were 1+ in no patients, 2+ in 4 patients, 3+ in 1 patient, and 4+ in 7 patients. Postoperative MU recruitment results were 1+ in 6 patients, 2+ in 5 patients, 3+ in 1 patient, and 4+ in no patients. Thinning of the affected fold during phonation was evident preoperatively in 9 of 10 patients. The affected and healthy folds were equal in volume in 4 of 9 patients postoperatively. The LEMG findings and coronal imaging suggest that NMP implantation may have enabled successful reinnervation of the laryngeal muscles of UVFP patients. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

Designing Solvent Exchange-Induced In Situ Forming Gel from Aqueous Insoluble Polymers as Matrix Base for Periodontitis Treatment.

PubMed

Srichan, Tharatree; Phaechamud, Thawatchai

2017-01-01

An in situ forming gel is a dosage form which is promised for site-specific therapy such as periodontal pocket of periodontitis treatment. Ethylcellulose, bleached shellac, and Eudragit RS were applied in this study as a polymeric matrix for in situ forming gel employing N-methyl pyrrolidone (NMP) as solvent. Solutions comprising ethylcellulose, bleached shellac, and Eudragit RS in NMP were evaluated for viscosity, rheology, and rate of water penetration. Ease of administration by injection was determined as the force required to expel polymeric solutions through a needle using texture analyzer. In vitro gel formation and in vitro gel degradation were conducted after injection into phosphate buffer solution pH 6.8. Ethylcellulose, bleached shellac, and Eudragit RS could form the in situ gel, in vitro. Gel viscosity and pH value depended on percentage amount of the polymer, whereas the water diffusion at early period likely relied on types of polymer. Furthermore, the solutions containing higher polymer concentration exhibited the lower degree of degradation. All the preparations were acceptable as injectable dosage forms because the applied force was lower than 50 N. All of them inhibited Staphylococcus aureus, Escherichia coli, Candida albicans, Streptococcus mutans, and Porphyrommonas gingivalis growth owing to antimicrobial activity of NMP which exhibited a potential use for periodontitis treatment. Moreover, the developed systems presented as the solvent exchange induced in situ forming gel and showed capability to be incorporated with the suitable antimicrobial active compounds for periodontitis treatment which should be further studied.

Effects of Phase Separation Behavior on Morphology and Performance of Polycarbonate Membranes.

PubMed

Idris, Alamin; Man, Zakaria; Maulud, Abdulhalim S; Khan, Muhammad Saad

2017-04-05

The phase separation behavior of bisphenol-A-polycarbonate (PC), dissolved in N -methyl-2-pyrrolidone and dichloromethane solvents in coagulant water, was studied by the cloud point method. The respective cloud point data were determined by titration against water at room temperature and the characteristic binodal curves for the ternary systems were plotted. Further, the physical properties such as viscosity, refractive index, and density of the solution were measured. The critical polymer concentrations were determined from the viscosity measurements. PC/NMP and PC/DCM membranes were fabricated by the dry-wet phase inversion technique and characterized for their morphology, structure, and thermal stability using field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis, respectively. The membranes' performances were tested for their permeance to CO₂, CH₄, and N₂ gases at 24 ± 0.5 °C with varying feed pressures from 2 to 10 bar. The PC/DCM membranes appeared to be asymmetric dense membrane types with appreciable thermal stability, whereas the PC/NMP membranes were observed to be asymmetric with porous structures exhibiting 4.18% and 9.17% decrease in the initial and maximum degradation temperatures, respectively. The ideal CO₂/N₂ and CO₂/CH₄ selectivities of the PC/NMP membrane decreased with the increase in feed pressures, while for the PC/DCM membrane, the average ideal CO₂/N₂ and CO₂/CH₄ selectivities were found to be 25.1 ± 0.8 and 21.1 ± 0.6, respectively. Therefore, the PC/DCM membranes with dense morphologies are appropriate for gas separation applications.

Autonomous Satellite Command and Control through the World Wide Web: Phase 3

NASA Technical Reports Server (NTRS)

Cantwell, Brian; Twiggs, Robert

1998-01-01

NASA's New Millenium Program (NMP) has identified a variety of revolutionary technologies that will support orders of magnitude improvements in the capabilities of spacecraft missions. This program's Autonomy team has focused on science and engineering automation technologies. In doing so, it has established a clear development roadmap specifying the experiments and demonstrations required to mature these technologies. The primary developmental thrusts of this roadmap are in the areas of remote agents, PI/operator interface, planning/scheduling fault management, and smart execution architectures. Phases 1 and 2 of the ASSET Project (previously known as the WebSat project) have focused on establishing World Wide Web-based commanding and telemetry services as an advanced means of interfacing a spacecraft system with the PI and operators. Current automated capabilities include Web-based command submission, limited contact scheduling, command list generation and transfer to the ground station, spacecraft support for demonstrations experiments, data transfer from the ground station back to the ASSET system, data archiving, and Web-based telemetry distribution. Phase 2 was finished in December 1996. During January-December 1997 work was commenced on Phase 3 of the ASSET Project. Phase 3 is the subject of this report. This phase permitted SSDL and its project partners to expand the ASSET system in a variety of ways. These added capabilities included the advancement of ground station capabilities, the adaptation of spacecraft on-board software, and the expansion of capabilities of the ASSET management algorithms. Specific goals of Phase 3 were: (1) Extend Web-based goal-level commanding for both the payload PI and the spacecraft engineer; (2) Support prioritized handling of multiple PIs as well as associated payload experimenters; (3) Expand the number and types of experiments supported by the ASSET system and its associated spacecraft; (4) Implement more advanced resource management, modeling and fault management capabilities that integrate the space and ground segments of the space system hardware; (5) Implement a beacon monitoring test; (6) Implement an experimental blackboard controller for space system management; (7) Further define typical ground station developments required for Internet-based remote control and for full system automation of the PI-to-spacecraft link. Each of those goals is examined in the next section. Significant sections of this report were also published as a conference paper.

RHEOLOGY OF CONCENTRATED SOLUTIONS OF HYPERBRANCHED POLYESTERS

EPA Science Inventory

The solution rheology of different generations of hyperbranched polyesters in N-methyl-2- pyrrolidinone (NMP) solvent was examined in this study. The solutions exhibited Newtonian behavior over a wide range of polyester concentrations. Also, the relative viscosities of poly(amido...

Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds.

PubMed

Rustom, Laurence E; Boudou, Thomas; Lou, Siyu; Pignot-Paintrand, Isabelle; Nemke, Brett W; Lu, Yan; Markel, Mark D; Picart, Catherine; Wagoner Johnson, Amy J

2016-10-15

The increasing demand for bone repair solutions calls for the development of efficacious bone scaffolds. Biphasic calcium phosphate (BCP) scaffolds with both macropores and micropores (MP) have improved healing compared to those with macropores and no micropores (NMP), but the role of micropores is unclear. Here, we evaluate capillarity induced by micropores as a mechanism that can affect bone growth in vivo. Three groups of cylindrical scaffolds were implanted in pig mandibles for three weeks: MP were implanted either dry (MP-Dry), or after submersion in phosphate buffered saline, which fills pores with fluid and therefore suppresses micropore-induced capillarity (MP-Wet); NMP were implanted dry. The amount and distribution of bone in the scaffolds were quantified using micro-computed tomography. MP-Dry had a more homogeneous bone distribution than MP-Wet, although the average bone volume fraction, BVF‾, was not significantly different for these two groups (0.45±0.03 and 0.37±0.03, respectively). There was no significant difference in the radial bone distribution of NMP and MP-Wet, but the BVF‾, of NMP was significantly lower among the three groups (0.25±0.02). These results suggest that micropore-induced capillarity enhances bone regeneration by improving the homogeneity of bone distribution in BCP scaffolds. The explicit design and use of capillarity in bone scaffolds may lead to more effective treatments of large and complex bone defects. The increasing demand for bone repair calls for more efficacious bone scaffolds and calcium phosphate-based materials are considered suitable for this application. Macropores (>100μm) are necessary for bone ingrowth and vascularization. However, studies have shown that microporosity (<20μm) also enhances growth, but there is no consensus on the controlling mechanisms. In previous in vitro work, we suggested that micropore-induced capillarity had the potential to enhance bone growth in vivo. This work illustrates the positive effects of capillarity on bone regeneration in vivo; it demonstrates that micropore-induced capillarity significantly enhances the bone distribution in the scaffold. The results will impact the design of scaffolds to better exploit capillarity and improve treatments for large and load-bearing bone defects. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Evaluating the learning experience of non medical prescribing students with their designated medical practitioners in their period of learning in practice: results of a survey.

PubMed

Ahuja, Jaya

2009-11-01

To evaluate the learning experience of non medical prescribing (NMP) students during their period of learning in practice and to explore strategies for improvement. A self-administered questionnaire was used to collect data from two consecutive NMP student cohorts. Of 57 NMP students, the majority (64.9%) worked in primary care setting. In contrast to those from primary care setting, the students working in secondary/tertiary care setting had significantly greater chance of knowing their designated medical practitioner (DMP) prior to starting their course (p=0.044). However, this did not influence whether the student did a learning agreement and time schedule agreement with the DMP at the beginning of practice setting. A learning agreement and time schedule was done by 91.2% and 57.9% students, respectively, at beginning of the course. Prior time schedule agreement was a significant determinant in determining the number of hours that student spent subsequently under direct supervision of DMP: 75.8% of those who did a prior time schedule spent >30% of practice hours under the direct supervision of DMP as compared to only 50% of those who did not. Spending >30% of the practice hours under direct supervision of the DMP was significantly associated with student satisfaction (p=0.025). There was greater likelihood of a student being assessed formatively if a prior learning agreement had been done (p=0.035) resulting in increased student satisfaction. Time and workload constraints, organisational issues and peer support emerged as barriers to student learning. Students commented on difficulties in getting doctors as a DMP; and therefore suggested that learning experience can be enhanced if a qualified practicing Non Medical Prescriber could act as a "co-mentor". There were also suggestions of providing incentives to doctors and giving them more information about the role of NMP to encourage more doctors to act as DMP. Learning agreement and a time schedule with DMP at the beginning of the supervised period in practice significantly improved the students' learning experience, and was a major determinant of subsequent student satisfaction. Those who spent at least 30% of practice development time under direct supervision of their DMP were likely to be more satisfied with the learning process.

TSCA Work Plan Chemical Risk Assessment N-Methylpyrrolidone: Paint Stripper Use

EPA Pesticide Factsheets

This final assessment for N-Methylpyrrolidone identified acute and chronic health risks to people, particularly pregnant women and women of childbearing age, who who are exposed to paint and coating removal products containing high concentrations of NMP.

Transit Feasibility Study Guilford Courthouse National Military Park.

DOT National Transportation Integrated Search

2009-02-28

This study is intended to be a broad overview of the transit feasibility at Guilford Courthouse NMP. The study will discuss the project background and context, and outline the two options for transit service. A detailed evaluation of costs and benefi...

Proposed Modification to Sebade Farms Nutrient Management Plan

EPA Pesticide Factsheets

Sebade Farms is a concentrated animal feeding operation (CAFO) located on the Winnebago Reservation in Nebraska that confines a total of 6,500 head of cattle. The terms of the Nutrient Management Plan (NMP) are incorporated by reference into the facility’s

Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage λ phosphatase

PubMed Central

Keppetipola, Niroshika; Shuman, Stewart

2007-01-01

Clostridium thermocellum polynucleotide kinase-phosphatase (CthPnkp) catalyzes 5′ and 3′ end-healing reactions that prepare broken RNA termini for sealing by RNA ligase. The central phosphatase domain of CthPnkp belongs to the dinuclear metallophosphoesterase superfamily exemplified by bacteriophage λ phosphatase (λ-Pase). CthPnkp is a Ni2+/Mn2+-dependent phosphodiesterase-monoesterase, active on nucleotide and non-nucleotide substrates, that can be transformed toward narrower metal and substrate specificities via mutations of the active site. Here we characterize the Mn2+-dependent 2′,3′ cyclic nucleotide phosphodiesterase activity of CthPnkp, the reaction most relevant to RNA repair pathways. We find that CthPnkp prefers a 2′,3′ cyclic phosphate to a 3′,5′ cyclic phosphate. A single H189D mutation imposes strict specificity for a 2′,3′ cyclic phosphate, which is cleaved to form a single 2′-NMP product. Analysis of the cyclic phosphodiesterase activities of mutated CthPnkp enzymes illuminates the active site and the structural features that affect substrate affinity and kcat. We also characterize a previously unrecognized phosphodiesterase activity of λ-Pase, which catalyzes hydrolysis of bis-p-nitrophenyl phosphate. λ-Pase also has cyclic phosphodiesterase activity with nucleoside 2′,3′ cyclic phosphates, which it hydrolyzes to yield a mixture of 2′-NMP and 3′-NMP products. We discuss our results in light of available structural and functional data for other phosphodiesterase members of the binuclear metallophosphoesterase family and draw inferences about how differences in active site composition influence catalytic repertoire. PMID:17986465

Effects of Phase Separation Behavior on Morphology and Performance of Polycarbonate Membranes

PubMed Central

Idris, Alamin; Man, Zakaria; Maulud, Abdulhalim S.; Khan, Muhammad Saad

2017-01-01

The phase separation behavior of bisphenol-A-polycarbonate (PC), dissolved in N-methyl-2-pyrrolidone and dichloromethane solvents in coagulant water, was studied by the cloud point method. The respective cloud point data were determined by titration against water at room temperature and the characteristic binodal curves for the ternary systems were plotted. Further, the physical properties such as viscosity, refractive index, and density of the solution were measured. The critical polymer concentrations were determined from the viscosity measurements. PC/NMP and PC/DCM membranes were fabricated by the dry-wet phase inversion technique and characterized for their morphology, structure, and thermal stability using field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis, respectively. The membranes’ performances were tested for their permeance to CO2, CH4, and N2 gases at 24 ± 0.5 °C with varying feed pressures from 2 to 10 bar. The PC/DCM membranes appeared to be asymmetric dense membrane types with appreciable thermal stability, whereas the PC/NMP membranes were observed to be asymmetric with porous structures exhibiting 4.18% and 9.17% decrease in the initial and maximum degradation temperatures, respectively. The ideal CO2/N2 and CO2/CH4 selectivities of the PC/NMP membrane decreased with the increase in feed pressures, while for the PC/DCM membrane, the average ideal CO2/N2 and CO2/CH4 selectivities were found to be 25.1 ± 0.8 and 21.1 ± 0.6, respectively. Therefore, the PC/DCM membranes with dense morphologies are appropriate for gas separation applications. PMID:28379173

Serial urinary IL-2, IL-6, IL-8, TNFalpha, UBC, CYFRA 21-1 and NMP22 during follow-up of patients with bladder cancer receiving intravesical BCG.

PubMed

Sanchez-Carbayo, M; Urrutia, M; Romani, R; Herrero, M; Gonzalez de Buitrago, J M; Navajo, J A

2001-01-01

We evaluated the potential role of serial preinstillation levels of several interleukins, TNFalpha and urinary tumor markers to monitor patients with bladder cancer receiving intravesical BCG. 121 urine samples were collected from: patients with bladder cancer treated with BCG (group 1); patients with bladder cancer receiving other intravesical treatment (group 2) and patients with urinary tract infections (group 3). Cytokines [IL-2, IL6 and [L8] and TNFalpha and urinary tumor markers [UBC, CYFRA 21-1 and NMP22] were measured by immunoassays. In 3 out of 15 BCG non-responders that recurred over the period of the study, no cytokine peak for IL-2, IL-6 or TNFa were detected. Urinary tumor markers increased in 2 out of 3 of these patients earlier than scheduled cystoscopies. Cytokine measurement was heterogeneous among 12 out of 15 BCG-responding patients: there were low levels of IL-6 and TNFalpha and peaks of IL-2 and IL-8 in 10 out of 12 and 4 out of 12 patients, respectively. During responding patients' follow-up we observed false-positive results in 7 out of 65 urine samples for UBC, 8 out of 65 for CYFRA 21-1 and 20 out of 65 for NMP22. Urinary tract infections were the main factor associated with non-specific elevations of IL-6 and IL-8 and urinary tumor markers in all groups of patients. Although larger series are required to confirn our preliminary observations, our data argue for a potential predictive role for IL-2 of favourable response to BCG therapy. Monitoring BCG with urinary tumor markers could early detect recurrence in non-responding patients.

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect.

PubMed

Abel, Silvestre Bongiovanni; Yslas, Edith I; Rivarola, Claudia R; Barbero, Cesar A

2018-03-23

Polyaniline nanoparticles (PANI-NPs) were easily obtained applying the solvent displacement method by using N-methylpyrrolidone (NMP) as good solvent and water as poor solvent. Different polymers such as polyvinylpyrrolidone (PVP), chondroitin sulfate (ChS), polyvinyl alcohol (PVA), and polyacrylic acid (PAA) were used as stabilizers. Dynamic light scattering and scanning electron microscopy corroborated the size and morphology of the formed NPs. It was demonstrated that the size of nanoparticles could be controlled by setting the concentration of PANI in NMP, the NMP to water ratio, and the stabilizer's nature. The functionalization and fluorescence of NPs were checked by spectroscopic techniques. Since polyaniline show only weak intrinsic luminescence, fluorescent groups were linked to the polyaniline chains prior to the nanoparticle formation using a linker. Polyaniline chains were functionalized by nucleophilic addition of cysteamine trough the thiol group thereby incorporating pendant primary aliphatic amine groups to the polyaniline backbone. Then, dansyl chloride (DNS-Cl), which could act as an extrinsic chromophore, was conjugated to the amine pendant groups. Later, the functionalized polyaniline was used to produce nanoparticles by solvent displacement. The optical and functional properties of fluorescent nanoparticles (F-PANI-NPs) were determined. F-PANI-NPs in the conductive state (pH < 4) are able to absorb near infrared radiation (NIR) creating a photothermal effect in an aqueous medium. Thus, multifunctional nanoparticles are obtained. The application of NIR on a F-PANI-NPs dispersion in contact with Pseudomonas aeruginosa causes bacterial death. Therefore, the F-PANI-NPs could be tracked and applied to inhibit different diseases caused by pathogenic microorganisms and resistant to antibiotics as well as a new disinfection method to surgical materials.

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Dong; N. Paterson; S.G. Kazarian

A suite of tuyere-level coke samples have been withdrawn from a working blast furnace during coal injection, using the core-drilling technique. The samples have been characterized by size exclusion chromatography (SEC), Fourier transform Raman spectroscopy (FT-RS), and X-ray powder diffraction (XRD) spectroscopy. The 1-methyl-2-pyrrolidinone (NMP) extracts of the cokes sampled from the 'bosh', the rear of the 'bird's nest', and the 'dead man' zones were found by SEC to contain heavy soot-like materials (ca. 10{sup 7}-10{sup 8} apparent mass units). In contrast, NMP extracts of cokes taken from the raceway and the front of the 'bird's nest' only contained amore » small amount of material of relatively lower apparent molecular mass (up to ca. 10{sup 5} u). Since the feed coke contained no materials extractable by the present method, the soot-like materials are thought to have formed during the reactions of volatile matter released from the injectant coal, probably via dehydrogenation and repolymerization of the tars. The Raman spectra of the NMP-extracted core-drilled coke samples showed variations reflecting their temperature histories. Area ratios of D-band to G-band decreased as the exposure temperature increased, while intensity ratios of D to G band and those of 2D to G bands increased with temperature. The graphitic (G), defect (D), and random (R) fractions of the carbon structure of the cokes were also derived from the Raman spectra. The R fractions decreased with increasing temperature, whereas G fractions increased, while the D fractions showed a more complex variation with temperature. These data appear to give clues regarding the graphitization mechanism of tuyere-level cokes in the blast furnace. 41 refs., 9 figs., 6 tabs.« less

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect

NASA Astrophysics Data System (ADS)

Bongiovanni Abel, Silvestre; Yslas, Edith I.; Rivarola, Claudia R.; Barbero, Cesar A.

2018-03-01

Polyaniline nanoparticles (PANI-NPs) were easily obtained applying the solvent displacement method by using N-methylpyrrolidone (NMP) as good solvent and water as poor solvent. Different polymers such as polyvinylpyrrolidone (PVP), chondroitin sulfate (ChS), polyvinyl alcohol (PVA), and polyacrylic acid (PAA) were used as stabilizers. Dynamic light scattering and scanning electron microscopy corroborated the size and morphology of the formed NPs. It was demonstrated that the size of nanoparticles could be controlled by setting the concentration of PANI in NMP, the NMP to water ratio, and the stabilizer’s nature. The functionalization and fluorescence of NPs were checked by spectroscopic techniques. Since polyaniline show only weak intrinsic luminescence, fluorescent groups were linked to the polyaniline chains prior to the nanoparticle formation using a linker. Polyaniline chains were functionalized by nucleophilic addition of cysteamine trough the thiol group thereby incorporating pendant primary aliphatic amine groups to the polyaniline backbone. Then, dansyl chloride (DNS-Cl), which could act as an extrinsic chromophore, was conjugated to the amine pendant groups. Later, the functionalized polyaniline was used to produce nanoparticles by solvent displacement. The optical and functional properties of fluorescent nanoparticles (F-PANI-NPs) were determined. F-PANI-NPs in the conductive state (pH < 4) are able to absorb near infrared radiation (NIR) creating a photothermal effect in an aqueous medium. Thus, multifunctional nanoparticles are obtained. The application of NIR on a F-PANI-NPs dispersion in contact with Pseudomonas aeruginosa causes bacterial death. Therefore, the F-PANI-NPs could be tracked and applied to inhibit different diseases caused by pathogenic microorganisms and resistant to antibiotics as well as a new disinfection method to surgical materials.

Volatile Organic Compounds Enhance Allergic Airway Inflammation in an Experimental Mouse Model

PubMed Central

Bönisch, Ulrike; Böhme, Alexander; Kohajda, Tibor; Mögel, Iljana; Schütze, Nicole; von Bergen, Martin; Simon, Jan C.; Lehmann, Irina; Polte, Tobias

2012-01-01

Background Epidemiological studies suggest an association between exposure to volatile organic compounds (VOCs) and adverse allergic and respiratory symptoms. However, whether VOCs exhibit a causal role as adjuvants in asthma development remains unclear. Methods To investigate the effect of VOC exposure on the development of allergic airway inflammation Balb/c mice were exposed to VOCs emitted by new polyvinylchloride (PVC) flooring, sensitized with ovalbumin (OVA) and characterized in acute and chronic murine asthma models. Furthermore, prevalent evaporated VOCs were analyzed and mice were exposed to selected single VOCs. Results Exposure of mice to PVC flooring increased eosinophilic lung inflammation and OVA-specific IgE serum levels compared to un-exposed control mice. The increased inflammation was associated with elevated levels of Th2-cytokines. Long-term exposure to PVC flooring exacerbated chronic airway inflammation. VOCs with the highest concentrations emitted by new PVC flooring were N-methyl-2-pyrrolidone (NMP) and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB). Exposure to NMP or TXIB also increased the allergic immune response in OVA-sensitized mice. In vitro or in vivo exposure to NMP or TXIB reduced IL-12 production in maturing dendritic cells (DCs) and enhanced airway inflammation after adoptive DC transfer into Balb/c mice. At higher concentrations both VOCs induced oxidative stress demonstrated by increased isoprostane and glutathione-S-transferase-pi1 protein levels in the lung of non-sensitized mice. Treatment of PVC flooring-exposed mice with N-acetylcysteine prevented the VOC-induced increase of airway inflammation. Conclusions Our results demonstrate that exposure to VOCs may increase the allergic immune response by interfering with DC function and by inducing oxidative stress and has therefore to be considerate as risk factor for the development of allergic diseases. PMID:22802943

Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model.

PubMed

Bönisch, Ulrike; Böhme, Alexander; Kohajda, Tibor; Mögel, Iljana; Schütze, Nicole; von Bergen, Martin; Simon, Jan C; Lehmann, Irina; Polte, Tobias

2012-01-01

Epidemiological studies suggest an association between exposure to volatile organic compounds (VOCs) and adverse allergic and respiratory symptoms. However, whether VOCs exhibit a causal role as adjuvants in asthma development remains unclear. To investigate the effect of VOC exposure on the development of allergic airway inflammation Balb/c mice were exposed to VOCs emitted by new polyvinylchloride (PVC) flooring, sensitized with ovalbumin (OVA) and characterized in acute and chronic murine asthma models. Furthermore, prevalent evaporated VOCs were analyzed and mice were exposed to selected single VOCs. Exposure of mice to PVC flooring increased eosinophilic lung inflammation and OVA-specific IgE serum levels compared to un-exposed control mice. The increased inflammation was associated with elevated levels of Th2-cytokines. Long-term exposure to PVC flooring exacerbated chronic airway inflammation. VOCs with the highest concentrations emitted by new PVC flooring were N-methyl-2-pyrrolidone (NMP) and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB). Exposure to NMP or TXIB also increased the allergic immune response in OVA-sensitized mice. In vitro or in vivo exposure to NMP or TXIB reduced IL-12 production in maturing dendritic cells (DCs) and enhanced airway inflammation after adoptive DC transfer into Balb/c mice. At higher concentrations both VOCs induced oxidative stress demonstrated by increased isoprostane and glutathione-S-transferase-pi1 protein levels in the lung of non-sensitized mice. Treatment of PVC flooring-exposed mice with N-acetylcysteine prevented the VOC-induced increase of airway inflammation. Our results demonstrate that exposure to VOCs may increase the allergic immune response by interfering with DC function and by inducing oxidative stress and has therefore to be considerate as risk factor for the development of allergic diseases.

Elucidation of a side reaction occurring during nitroxide-mediated polymerization of cyclic ketene acetals by tandem mass spectrometric end-group analysis of aliphatic polyesters.

PubMed

Albergaria Pereira, Bruna de Fátima; Tardy, Antoine; Monnier, Valérie; Guillaneuf, Yohann; Gigmes, Didier; Charles, Laurence

2015-12-15

In order to prevent side reactions while developing new polymerization processes, their mechanism has to be understood and one first key insight is the structure of the end-groups in polymeric by-products. The synthetic method scrutinized here is the nitroxide-mediated polymerization (NMP) of a cyclic ketene acetal, a promising alternative process to the production of polyesters. Polymer end-group characterization was performed by mass spectrometry (MS), combining elemental composition information derived from accurate mass data in the MS mode with fragmentation features recorded in the MS/MS mode. Electrospray was used as the ionization method to ensure the integrity of original chain terminations and a quadrupole time-of-flight (QTOF) instrument was employed for high-resolution mass measurements in both MS and tandem mass spectrometry (MS/MS) modes. Occurrence of side reactions in the studied polymerization method, first evidenced by an unusual increase in dispersity with conversion, was confirmed in MS with the detection of two polymeric impurities in addition to the expected species. Fragmentation rules were first established for this new polyester family in order to derive useful structural information from MS/MS data. In addition to a usual NMP by-product, the initiating group of the second polymeric impurities revealed the degradation of the nitroxide moiety. Unambiguous MS/MS identification of end-groups in by-products sampled from the polymerization medium allowed an unusual side reaction to be identified during the NMP preparation of polyesters. On-going optimization of the polymerization method aims at preventing this undesired process. Copyright © 2015 John Wiley & Sons, Ltd.

Microscale Alloy Type Lithium Ion Battery Anodes

DTIC Science & Technology

2015-09-01

hexamethyldisilazane Li lithium Ni nickel NMP n-methyl-2-pyrolidone RMS root mean square SEI solid electrolyte interphase SEM scanning electron microscopy...process also leads to an unstable solid electrolyte interphase (SEI) and further capacity loss. An extraordinary amount of work has been done in an...

Surfactant-assisted electrochemical deposition of α-cobalt hydroxide for supercapacitors

NASA Astrophysics Data System (ADS)

Zhao, Ting; Jiang, Hao; Ma, Jan

A N-methylpyrrolidone (NMP) assisted electrochemical deposition route has been developed to realize the synthesis of a dense α-Co(OH) 2 layered structure, which is composed of nanosheets, each with a thickness of 10 nm. The capacitive characteristics of the as-obtained α-Co(OH) 2 are investigated by means of cyclic voltammetry (CV), charge/discharge characterization, and electrochemical impedance spectroscopy (EIS), in 1 M KOH electrolyte. The results indicate that α-Co(OH) 2 prepared in the presence of 20 vol.% NMP has denser and thin layered structure which promotes an increased surface area and a shortened ion diffusion path. The as-prepared α-Co(OH) 2 shows better electrochemical performance with specific capacitance of 651 F g -1 in a potential range of -0.1 to 0.45 V. These findings suggest that the surfactant-assisted electrochemical deposition is a promising process for building densely packed material systems with enhanced properties, for application in supercapacitors.

Graphene-conducting polymer nanocomposite as novel electrode for supercapacitors

NASA Astrophysics Data System (ADS)

Gómez, Humberto; Ram, Manoj K.; Alvi, Farah.; Villalba, P.; Stefanakos, Elias (Lee); Kumar, Ashok

A novel graphene-polyaniline nanocomposite material synthesized using chemical precipitation technique is reported as an electrode for supercapacitors. The graphene (G)-polyaniline (PANI) nanocomposite film was dissolved in N-Methyl-2-pyrrolidone (NMP) and characterized using Raman, FTIR, Scanning Electron Microscopy, Transmission Electron Microscopy, and cyclic voltammetry (CV) techniques. The interesting composite structure could be observed using different ratios of graphene and aniline monomer. The supercapacitor is fabricated using G-PANI in N-Methyl-2-pyrrolidone (NMP) and G-PANI-Nafion films on graphite electrodes. A specific capacitance of 300-500 F g -1 at a current density of 0.1 A g -1 is observed over graphene-PANI nanocomposite materials. The aim of this study is to tailor the properties of the capacitors through the optimization of their components, and packaging towards a qualification for portable systems applications. Based on experimental data shown in this work, conducting polymer nanocomposite capacitor technology could be viable, and could also surpass existing technologies when such a novel approach is used.

Oxidation and formation of deposit precursors in hydrocarbon fuels

NASA Technical Reports Server (NTRS)

Mayo, F. R.; Lan, B.; Cotts, D. B.; Buttrill, S. E., Jr.; St.john, G. A.

1983-01-01

The oxidation of two jet turbine fuels and some pure hydrocarbons was studied at 130 C with and without the presence of small amounts of N-methyl pyrrole (NMP) or indene. Tendency to form solid-deposit precursors was studied by measuring soluble gum formation as well as dimer and trimer formation using field ionization mass spectrometry. Pure n-dodecane oxidized fastest and gave the smallest amount of procursors. An unstable fuel oil oxidized much slower but formed large amounts of precursors. Stable Jet A fuel oxidized slowest and gave little precursors. Indene either retarded or accelerated the oxidation of n-dodecane, depending on its concentration, but always caused more gum formation. The NMP greatly retarded n-dodecane oxidation but accelerated Jet A oxidation and greatly increased the latter's gum formation. In general, the additive reacted faster and formed most of the gum. Results are interpreted in terms of classical cooxidation theory. The effect of oxygen pressure on gum formation is also reported.

Are in situ formulations the keys for the therapeutic future of S-nitrosothiols?

PubMed

Parent, Marianne; Boudier, Ariane; Dupuis, François; Nouvel, Cécile; Sapin, Anne; Lartaud, Isabelle; Six, Jean-Luc; Leroy, Pierre; Maincent, Philippe

2013-11-01

S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were formulated into in situ forming implants (ISI) and microparticles (ISM) using PLGA and either N-methyl-2-pyrrolidone (NMP) or triacetin. Physicochemical characterization was carried out, including the study of matrix structure and degradation. A strong correlation between drug hydrophobicity and the in vitro release profiles was observed: whatever the formulation, GSNO and SNAP were completely released after ca. 1 day and 1 week, respectively. Then, selected formulations (i.e., SNAP-loaded NMP formulations) demonstrated the ability to sustain the vasodilation effect of SNAP, as shown by monitoring the arterial pressure (telemetry) of Wistar rats after subcutaneous injection. Both ISI and ISM injections resulted in a 3-fold extended decrease in pulse arterial pressure compared with the unloaded drug, without significant decrease in the mean arterial pressure. Hence, the results emphasize the suitability of these formulations as drug delivery systems for S-nitrosothiols, widening their therapeutic potential. Copyright © 2013 Elsevier B.V. All rights reserved.

[Nuclear protein matrix from giant nuclei of Chironomus plumosus determinates polythene chromosome organization].

PubMed

Makarov, M S; Chentsov, Iu S

2010-01-01

Giant nuclei from salivary glands of Chironomus plumosus were treated in situ with detergent, 2 M NaCl and nucleases in order to reveal residual nuclear matrix proteins (NMP). It was shown, that preceding stabilization of non-histone proteins with 2 mM CuCl2 allowed to visualize the structure of polythene chromosomes at every stage of the extraction of histones and DNA. Stabilized NPM of polythene chromosomes maintains their morphology and banding patterns, which is observed by light and electron microscopy, whereas internal fibril net or residual nucleoli are not found. In stabilized NPM of polythene chromosomes, topoisomerase IIalpha and SMC1 retain their localization that is typical of untreated chromosomes. NPM of polythene chromosomes also includes sites of DNA replication, visualized with BrDU incubation, and some RNA-components. So, we can conclude that structure of NPM from giant nuclei is equal to NPM from normal interphase nuclei, and that morphological features of polythene chromosomes depend on the presence of NMP.

Crystal Structure of Human Nicotinamide Riboside Kinase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan,J.; Xiang, S.; Tong, L.

2007-01-01

Nicotinamide riboside kinase (NRK) has an important role in the biosynthesis of NAD{sup +} as well as the activation of tiazofurin and other NR analogs for anticancer therapy. NRK belongs to the deoxynucleoside kinase and nucleoside monophosphate (NMP) kinase superfamily, although the degree of sequence conservation is very low. We report here the crystal structures of human NRK1 in a binary complex with the reaction product nicotinamide mononucleotide (NMN) at 1.5 {angstrom} resolution and in a ternary complex with ADP and tiazofurin at 2.7 {angstrom} resolution. The active site is located in a groove between the central parallel {beta} sheetmore » core and the LID and NMP-binding domains. The hydroxyl groups on the ribose of NR are recognized by Asp56 and Arg129, and Asp36 is the general base of the enzyme. Mutation of residues in the active site can abolish the catalytic activity of the enzyme, confirming the structural observations.« less

Synthesis and characterization of high performing Fe-N-C catalyst for oxygen reduction reaction (ORR) in Alkaline Exchange Membrane Fuel Cells

NASA Astrophysics Data System (ADS)

Hossen, Md Mosaddek; Artyushkova, Kateryna; Atanassov, Plamen; Serov, Alexey

2018-01-01

In this article, three different Fe-N-C oxygen reduction reaction (ORR) catalysts derived from different organic molecules i.e. Fe-NMG, Fe-NMP, Fe-MBZ have been synthesized, characterized by physical-chemical methods and studied in the reaction of oxygen reduction (ORR). It is found that Fe-NMG shows higher ORR performance than Fe-NMP and Fe-MBZ, by both rotating ring disk electrode (RRDE) and fuel cell tests. From characterization and surface analysis, it can be explained that the presence of higher amount of surface oxides and pyridinic nitrogen is the main reason for better performance towards ORR in alkaline media. To achieve the highest performance in alkaline exchange membrane fuel cell (AEMFC), the optimization of catalyst layer composition using various concentrations of ionomer (Tokuyama, AS4) was performed. At the optimum cathode layer configuration utilizing Fe-NMG produces the peak power density of 218 mWcm-2, which is one of the highest values presented in the open literature.

De-agglomeration and homogenisation of nanoparticles in coal tar pitch-based carbon materials

NASA Astrophysics Data System (ADS)

Gubernat, Maciej; Tomala, Janusz; Frohs, Wilhelm; Fraczek-Szczypta, Aneta; Blazewicz, Stanislaw

2016-03-01

The aim of the work was to characterise coal tar pitch (CTP) modified with selected nanoparticles as a binder precursor for the manufacture of synthetic carbon materials. Different factors influencing the preliminary preparative steps in the preparation of homogenous nanoparticle/CTP composition were studied. Graphene flakes, carbon black and nano-sized silicon carbide were used to modify CTP. Prior to introducing them into liquid CTP, nanoparticles were subjected to sonication. Various dispersants were used to prepare the suspensions, i.e. water, ethanol, dimethylformamide (DMF) and N-methylpyrrolidone (NMP).The results showed that proper dispersant selection is one of the most important factors influencing the de-agglomeration process of nanoparticles. DMF and NMP were found to be effective dispersants for the preparation of homogenous nanoparticle-containing suspensions. The presence of SiC and carbon black nanoparticles in the liquid pitch during heat treatment up to 2000 °C leads to the inhibition of crystallite growth in carbon residue.

Documents for SBAR Panel: Methylene Chloride and N-Methylpyrrolidone; Regulation of Certain Uses Under TSCA Section 6(a)

EPA Pesticide Factsheets

SBAR panel to to address the risks resulting from the manufacture, import, processing, distribution in commerce, and use of chemicals, as well as any manner or method of disposal of chemicals: n-methylpyrrolidone (NMP) and methylene chloride

SBAR Panel: Regulation of N-Methylpyrrolidone and Methylene Chloride in Paint and Coating Removal under Section 6(a) of the Toxic Substances Control Act

EPA Pesticide Factsheets

SBAR panel related to a rule that proposes to determine whether the continued use of NMP and methylene chloride in commercial and consumer paint and coating removers poses an unreasonable risk to human health and the environment

Laying the Foundations: Early Findings from the New Mathways Project

ERIC Educational Resources Information Center

Zachry Rutschow, Elizabeth; Diamond, John

2015-01-01

National studies reveal that 50 percent to 70 percent of community college students are required to take developmental, or remedial, math courses upon enrollment, and only 20 percent of developmental math students ever successfully complete a college-level math course. Taking up the challenge is the "New Mathways Project" (NMP),…

Candida albicans-induced inflammatory response in human keratinocytes.

PubMed

Wollina, U; Künkel, W; Bulling, L; Fünfstück, C; Knöll, B; Vennewald, I; Hipler, U-C

2004-06-01

Candida albicans strains 3153a, ATCC 48867, CBS 2730, DSM 70014, and Vir 13 were cultivated and sterile C. albicans filtrates were produced. The interaction of soluble Candida factors of these infiltrates with human HaCaT keratinocytes was assayed in vitro. The following parameters were analyzed: cell proliferation, protein synthesis, nuclear matrix protein (NMP) 41 release, cytokine release (IL-1beta, soluble IL-2 receptor, IL-6, and IL-8), and reactive oxygen species (ROS). Cell counts at 1, 12, and 24 h were significantly lower for C. albicans strains CBS 2730 and VIR 13 (P < 0.05). There was no significant change for the remaining strains. Neither the protein synthesis nor the NMP-41 release was significantly affected. IL-6 and IL-8 were stimulated by C. albicans filtrates to different amounts with higher levels in strains of low virulence. There was no effect on the other cytokines. The production of ROS by HaCaT keratinocytes was suppressed. The induction of an inflammatory keratinocyte response by soluble C. albicans factors may play a role among the host-yeast interactions.

Composite Properties of Polyimide Resins Made From "Salt-Like" Solution Precursors

NASA Technical Reports Server (NTRS)

Cano, Roberto J.; Weiser, Erik S.; SaintClair, Terry L.; Echigo, Yoshiaki; Kaneshiro, Hisayasu

1997-01-01

Recent work in high temperature materials at NASA Langley Research Center (LaRC (trademark)) have led to the development of new polyimide resin systems with very attractive properties. The majority of the work done with these resin systems has concentrated on determining engineering mechanical properties of composites prepared from a poly(amide acid) precursor. Three NASA Langley-developed polyimide matrix resins, LaRC (trademark) -IA, LaRC (trademark) -IAX, and LaRC (trademark) -8515, were produced via a salt-like process developed by Unitika Ltd. The 'salt-like' solutions (sixty-five percent solids in NMP) were prepregged onto Hexcel IM7 carbon fiber using the NASA LaRC Multipurpose Tape Machine. Process parameters were determined and composite panels fabricated. Mechanical properties are presented for these three intermediate modulus carbon fiber/polyimide matrix composites and compared to existing data on the same polyimide resin systems and IM7 carbon fiber manufactured via poly(amide acid) solutions (thirty-five percent solids in NMP). This work studies the effects of varying the synthetic route on the processing and mechanical properties of polyimide composites.

Poster - 03: How to manage a nuclear medicine PET-CT for radiation oncology patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinse, Martin; Létourneau, Étienne; Duplan, Danny

Purpose: Development of an adapted multidisciplinary procedure designed to optimize the clinical workflow between radiation therapy (RT) and nuclear medicine (NM) for a PET-CT located in the NM department. Methods : The radiation oncologist (RO) prescribes the PET-CT exam and the clinical RT therapist gives all the necessary information to the patient prior to the exam. The immobilization accessories are prepared in the RT department. The RT and NM therapists work together for radiotracer injection, patient positioning and scan acquisition. The nuclear medicine physician (NMP) will study the images, draw Biological Target Volumes (BTVs) and produce a full exam report.more » Results : All tasks related to a planning PET-CT are done within 48 hours from the request by the RO to the reception of the images with the NMP contours and report. Conclusions : By developing a complete procedure collectively between the RT and NM departments, the patient benefits of a quick access to a RT planning PET-CT exam including the active involvement of every medical practitioners in these fields.« less

Construction of genetically engineered M13K07 helper phage for simultaneous phage display of gold binding peptide 1 and nuclear matrix protein 22 ScFv antibody.

PubMed

Fatemi, Farnaz; Amini, Seyed Mohammad; Kharrazi, Sharmin; Rasaee, Mohammad Javad; Mazlomi, Mohammad Ali; Asadi-Ghalehni, Majid; Rajabibazl, Masoumeh; Sadroddiny, Esmaeil

2017-11-01

The most common techniques of antibody phage display are based on the use of M13 filamentous bacteriophages. This study introduces a new genetically engineered M13K07 helper phage displaying multiple copies of a known gold binding peptide on p8 coat proteins. The recombinant helper phages were used to rescue a phagemid vector encoding the p3 coat protein fused to the nuclear matrix protein 22 (NMP22) ScFv antibody. Transmission electron microscopy (TEM), UV-vis absorbance spectroscopy, and field emission scanning electron microscopy (FE-SEM) with energy dispersive X-ray spectroscopy (EDX) analysis revealed that the expression of gold binding peptide 1 (GBP1) on major coat protein p8 significantly enhances the gold-binding affinity of M13 phages. The recombinant bacteriophages at concentrations above 5×10 4 pfu/ml red-shifted the UV-vis absorbance spectra of gold nanoparticles (AuNPs); however, the surface plasmon resonance of gold nanoparticles was not changed by the wild type bacteriophages at concentrations up to 10 12 pfu/ml. The phage ELISA assay demonstrated the high affinity binding of bifunctional bacteriophages to NMP22 antigen at concentrations of 10 5 and 10 6 pfu/ml. Thus, the p3 end of the bifunctional bacteriophages would be able to bind to specific target antigen, while the AuNPs were assembled along the coat of virus for signal generation. Our results indicated that the complex of antigen-bacteriophages lead to UV-vis spectral changes of AuNPs and NMP22 antigen in concentration range of 10-80μg/ml can be detected by bifunctional bacteriophages at concentration of 10 4 pfu/ml. The ability of bifunctional bacteriophages to bind to antigen and generate signal at the same time, makes this approach applicable for identifying different antigens in immunoassay techniques. Copyright © 2017 Elsevier B.V. All rights reserved.

Differential expression of vacuolar and defective cell wall invertase genes in roots and seeds of metalliferous and non-metalliferous populations of Rumex dentatus under copper stress.

PubMed

Xu, Zhong-Rui; Cai, Shen-Wen; Huang, Wu-Xing; Liu, Rong-Xiang; Xiong, Zhi-Ting

2018-01-01

Acid invertase activities in roots and young seeds of a metalliferous population (MP) of Rumex dentatus were previously observed to be significantly higher than those of a non-metalliferous population (NMP) under Cu stress. To date, no acid invertase gene has been cloned from R. dentatus. Here, we isolated four full-length cDNAs from the two populations of R. dentatus, presumably encoding cell wall (RdnCIN1 and RdmCIN1 from the NMP and MP, respectively) and vacuolar invertases (RdnVIN1 and RdmVIN1 from the NMP and MP, respectively). Unexpectedly, RdnCIN1 and RdmCIN1 most likely encode special defective invertases with highly attenuated sucrose-hydrolyzing capacity. The transcript levels of RdmCIN1 were significantly higher than those of RdnCIN1 in roots and young seeds under Cu stress, whereas under control conditions, the former was initially lower than the latter. Unexpected high correlations were observed between the transcript levels of RdnCIN1 and RdmCIN1 and the activity of cell wall invertase, even though RdnCIN1 and RdmCIN1 do not encode catalytically active invertases. Similarly, the transcript levels of RdmVIN1 in roots and young seeds were increased under Cu stress, whereas those of RdnVIN1 were decreased. The high correlations between the transcript levels of RdnVIN1 and RdmVIN1 and the activity of vacuolar invertase indicate that RdnVIN1 and RdmVIN1 might control distinct vacuolar invertase activities in the two populations. Moreover, a possible indirect role for acid invertases in Cu tolerance, mediated by generating a range of sugars used as nutrients and signaling molecules, is discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

Bismaleimide resins for flame resistant honeycomb sandwich panels

NASA Technical Reports Server (NTRS)

1978-01-01

A 60 kg batch of Resin M751 was produced in pilot plant scale. The resin was delivered to the prepreg company as an NMP solution. 100 kg of glass-fabric prepregs were fabricated. Prepreg characteristics and curing cycles for laminate fabrication were provided. A new batch of Resin M756 (Code M756 - 2) was synthesized.

Phonological Neighborhood Effects in Spoken Word Production: An fMRI Study

ERIC Educational Resources Information Center

Peramunage, Dasun; Blumstein, Sheila E.; Myers, Emily B.; Goldrick, Matthew; Baese-Berk, Melissa

2011-01-01

The current study examined the neural systems underlying lexically conditioned phonetic variation in spoken word production. Participants were asked to read aloud singly presented words, which either had a voiced minimal pair (MP) neighbor (e.g., cape) or lacked a minimal pair (NMP) neighbor (e.g., cake). The voiced neighbor never appeared in the…

76 FR 73721 - Nine Mile Point Nuclear Station, LLC, Nine Mile Point Nuclear Station, Unit No. 2, Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... used during plant modifications. Therefore, land use conditions would not change at NMP2. Also, there would be no land use changes along transmission lines (no new lines would be required for the proposed EPU), transmission corridors, switch yards, or substations. Since land use conditions would not change...

Grassland and shrubland birds of Gettysburg National Military Park and Eisenhower National Historic Site: Current status and management recommendations

USGS Publications Warehouse

Peterjohn, Bruce G.

2007-01-01

Gettysburg National Military Park (NMP) and Eisenhower National Historic Site (NHS) were surveyed for grassland birds during the 2005 breeding season. These parks currently maintain a total of approximately 1,220 ha (3,015 ac) of grassland habitats within a mosaic of cultivated fields and woodlands. The grasslands are hayfields managed through agricultural leases and fields maintained by the National Park Service (NPS). Most grasslands are composed of introduced cool-season grasses, but Gettysburg NMP maintains a few fields dominated by switchgrass (Panicum virgatum) and is creating additional warm-season grasslands. Hayfields managed through agricultural leases support few grassland birds. The most numerous grassland bird communities are found between Seminary and Cemetery ridges in fields managed by the NPS. The parks discourage hay harvesting before July in all fields in an effort to improve the reproductive success of grassland birds.Shrub-dominated habitats were scarce in both parks. A few areas that were harvested recently for timber supported early successional communities in Gettysburg NMP. Other shrublands were limited to narrow corridors (<10 m [32 ft]) bordering fields and drainages. No shrublands were present on Eisenhower NHS, but an abandoned pasture along Willoughby Run was reverting into a mesic shrubland.Four species of obligate grassland birds were recorded during the 2005 surveys. A population of approximately 130 bobolinks (Dolichonyx oryzivorus) was primarily restricted to grasslands between Seminary and Cemetery ridges maintained by the NPS and a hayfield on Eisenhower NHS. This population is large for southeastern Pennsylvania and the surrounding region. Eastern meadowlarks (Sturnella magna) were most numerous in the same fields occupied by bobolinks but smaller numbers were scattered in other grasslands. Grasshopper sparrows (Ammodramus savannarum) were locally distributed in Conservation Reserve Program fields and other grasslands with more open vegetation. Savannah sparrows (Passervulus sandwichensis) were limited to one disturbed area undergoing conversion to warm-season grasses. When compared with other cultural parks in this region, the Gettysburg-Eisenhower complex supports a relatively abundant grassland bird community. This community is restricted to a portion of existing grassland habitats, but the potential exists to support a more diverse and abundant grassland avifauna.The following recommendations provide the most immediate benefits for breeding grassland birds in these parks under the current habitat conditions and management strategies. These recommendations are based on the assumption that the current policy of delayed mowing continues in both parks: improve grassland composition on leased hayfields; increase extent of early successional stages of grasslands; reduce fragmentation of grassland habitats; and improve grassland diversity by creating additional communities of native warm-season grasses.Because shrublands are currently scarce in both parks, the only recommendation is directed towards creating and maintaining shrub-dominated successional habitats: Explore opportunities for creating shrubby successional habitats in both parks.

75 FR 17970 - Nine Mile Point Nuclear Station, LLC; Nine Mile Point Nuclear Station, Unit No. 2; Draft...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... industrial use. Potable water in the area is supplied to residents either through the Scriba Water District... and drift losses from the cooling tower. NMP2 has its own cooling water intake and discharge... service water system and makeup to the circulating water system to replace evaporation and drift losses...

Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents.

PubMed

Ottesen, Lars K; Ek, Fredrik; Olsson, Roger

2006-04-27

[reaction: see text] A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO(2)Me) gave excellent yields (89%).

Dispersions of TiS2 nanosheets in organic medium

NASA Astrophysics Data System (ADS)

Manjunatha, S.; Kumar, A. Sunil; Machappa, T.

2018-05-01

Here in this article, we report Li-intercalated titanium disulfide (TiS2) two-dimensional (2D) nanosheets, exfoliated in 1-methyl-2-pyrrolidinone (NMP) forming a quite stable dispersions of pale brownish color. As synthesized TiS2 nanosheets were characterized by transmission electron microscopy (TEM). Selected area electron diffraction (SAED) pattern confirmed the hexagonal lattice structure of the exfoliated nanosheets.

Neuronal ensemble control of prosthetic devices by a human with tetraplegia

NASA Astrophysics Data System (ADS)

Hochberg, Leigh R.; Serruya, Mijail D.; Friehs, Gerhard M.; Mukand, Jon A.; Saleh, Maryam; Caplan, Abraham H.; Branner, Almut; Chen, David; Penn, Richard D.; Donoghue, John P.

2006-07-01

Neuromotor prostheses (NMPs) aim to replace or restore lost motor functions in paralysed humans by routeing movement-related signals from the brain, around damaged parts of the nervous system, to external effectors. To translate preclinical results from intact animals to a clinically useful NMP, movement signals must persist in cortex after spinal cord injury and be engaged by movement intent when sensory inputs and limb movement are long absent. Furthermore, NMPs would require that intention-driven neuronal activity be converted into a control signal that enables useful tasks. Here we show initial results for a tetraplegic human (MN) using a pilot NMP. Neuronal ensemble activity recorded through a 96-microelectrode array implanted in primary motor cortex demonstrated that intended hand motion modulates cortical spiking patterns three years after spinal cord injury. Decoders were created, providing a `neural cursor' with which MN opened simulated e-mail and operated devices such as a television, even while conversing. Furthermore, MN used neural control to open and close a prosthetic hand, and perform rudimentary actions with a multi-jointed robotic arm. These early results suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.

Synthesis, crystal structure and catalytic effect on thermal decomposition of RDX and AP: An energetic coordination polymer [Pb{sub 2}(C{sub 5}H{sub 3}N{sub 5}O{sub 5}){sub 2}(NMP)·NMP]{sub n}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Jin-jian; Yancheng Teachers College, Yancheng 224002; Liu, Zu-Liang, E-mail: liuzl@mail.njust.edu.cn

2013-04-15

An energetic lead(II) coordination polymer based on the ligand ANPyO has been synthesized and its crystal structure has been got. The polymer was characterized by FT-IR spectroscopy, elemental analysis, DSC and TG-DTG technologies. Thermal analysis shows that there are one endothermic process and two exothermic decomposition stages in the temperature range of 50–600 °C with final residues 57.09%. The non-isothermal kinetic has also been studied on the main exothermic decomposition using the Kissinger's and Ozawa–Doyle's methods, the apparent activation energy is calculated as 195.2 KJ/mol. Furthermore, DSC measurements show that the polymer has significant catalytic effect on the thermal decompositionmore » of ammonium perchlorate. - Graphical abstract: An energetic lead(II) coordination polymer of ANPyO has been synthesized, structurally characterized and properties tested. Highlights: ► We have synthesized and characterized an energetic lead(II) coordination polymer. ► We have measured its molecular structure and thermal decomposition. ► It has significant catalytic effect on thermal decomposition of AP.« less

Polyimide Composites from 'Salt-Like' Solution Precursors

NASA Technical Reports Server (NTRS)

Cano, Roberto J.; Hou, Tan H.; Weiser, Erik S.; SaintClair, Terry L.

2001-01-01

Four NASA Langley-developed polyimide matrix resins, LaRC(TM)-IA, LaRC(TM)-IAX, LaRC(TM)-8515 and LaRC(TM)-PETI-5, were produced via a 'saltlike' process developed by Unitika Ltd. The salt-like solutions (65% solids in NMP) were prepregged onto Hexcel IM7 carbon fiber using the NASA LaRC multipurpose tape machine. Process parameters were determined and composite panels fabricated. The temperature dependent volatile depletion rates, the thermal crystallization behavior and the resin rheology were characterized. Composite molding cycles were developed which consistently yielded well consolidated, void-free laminated parts. Composite mechanical properties such as the short beam shear strength; the longitudinal and transverse flexural strength and flexural modulus; the longitudinal compression strength and modulus; and the open hole compression strength and compression after impact strength were measured at room temperature and elevated temperatures. The processing characteristics and the composite mechanical properties of the four intermediate modulus carbon fiber/polyimide matrix composites were compared to existing data on the same polyimide resin systems and IM7 carbon fiber manufactured via poly(amide acid) solutions (30-35% solids in NMP). This work studies the effects of varying the synthetic route on the processing and mechanical properties of the polyimide composites.

Two-dimensional electrophoretic analysis of nuclear matrix proteins in human colon adenocarcinoma.

PubMed

Toumpanaki, A; Baltatzis, G E; Gaitanarou, E; Seretis, E; Toumpanakis, C; Aroni, K; Kittas, Christos; Voloudakis-Baltatzis, I E

2009-01-01

The aim of the present study was to observe possible qualitative and quantitative expression differences between nuclear matrix proteins (NMPs) of human colon adenocarcinoma and their mirror biopsies, using the technique of two-dimensional gel electrophoresis, in order to identify the existence of specific NMP fingerprints for colon cancer. Colon tissues were examined ultrastructurally and NMPs were isolated biochemically, by serial extraction of lipids, soluble proteins, DNA, RNA, and intermediate filaments and were separated according to their isoelectric point (pI) and their molecular weight (MW) by high-resolution two-dimensional electrophoresis (2D). By comparing the 2D electropherograms of colon cancer tissues and mirror biopsy tissues we observed qualitative and quantitative expression differences between their NMPs but also a differentiation of NMP composition between the stages of malignancy. Moreover, despite the similarities between mirror biopsy samples, a highlight percentage of exception was observed. Electrophoretic results provided in this study demonstrated that the examined NMPs could be further investigated as potential markers for detection of colorectal cancer in an early stage, for the assessment of the disease progression, as well as useful tools for individual therapy and for preventing a possible recurrence of cancer and metastasis.

Research on Hydrophilic Nature of Polyvinylpyrrolidone on Polysulfone Membrane Filtration

NASA Astrophysics Data System (ADS)

Tiron, L. G.; Vlad, M.; Baltă, Ş.

2018-06-01

The membranes used in wastewater filtration are obtained from polymers, this technique is widely applied because of the small installations and low costs as against conventional systems. The polymeric membranes have high mechanical strength and flexibility, but is a challenge to improve in the same time the permeability and retention capacity of the membranes. A process that can improve the membrane properties is the addition of additives to the polymer solution, resulting in noticeable changes in the resulting membrane structure. Polyvinylpyrrolidone (PVP) is a highly hydrophilic polymer, used as a food additive that acts as stabilizer and thickening agent, which brings improvements in membrane properties. This study analyses the effect of polyvinylpyrrolidone (PVP) on the casting solution of the prepared membranes. The polymer solution was prepared from polysulfone (PSf) and N-methyl-2-pyrrolidone (NMP) at different concentrations. The membranes were obtained by phase inversion method. The PSf/PVP/NMP membranes with different concentrations were characterized by contact angle measurements, surface roughness, morphological structure and permeation tests. The results show that the hydrophilic nature of PVP improve the pure water flux, the contact angle and exhibit a higher anti-fouling property.

Combined feedforward and model-assisted active disturbance rejection control for non-minimum phase system.

PubMed

Sun, Li; Li, Donghai; Gao, Zhiqiang; Yang, Zhao; Zhao, Shen

2016-09-01

Control of the non-minimum phase (NMP) system is challenging, especially in the presence of modelling uncertainties and external disturbances. To this end, this paper presents a combined feedforward and model-assisted Active Disturbance Rejection Control (MADRC) strategy. Based on the nominal model, the feedforward controller is used to produce a tracking performance that has minimum settling time subject to a prescribed undershoot constraint. On the other hand, the unknown disturbances and uncertain dynamics beyond the nominal model are compensated by MADRC. Since the conventional Extended State Observer (ESO) is not suitable for the NMP system, a model-assisted ESO (MESO) is proposed based on the nominal observable canonical form. The convergence of MESO is proved in time domain. The stability, steady-state characteristics and robustness of the closed-loop system are analyzed in frequency domain. The proposed strategy has only one tuning parameter, i.e., the bandwidth of MESO, which can be readily determined with a prescribed robustness level. Some comparative examples are given to show the efficacy of the proposed method. This paper depicts a promising prospect of the model-assisted ADRC in dealing with complex systems. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

An investigation on the effect of deposition parameters on nanostructured electrode of lithium ion batteries and their performance

NASA Astrophysics Data System (ADS)

Dorri, Mehrdad; Zamani, Cyrus; Babaei, Alireza

2018-01-01

Nanostructured plate-like manganese cobalt oxide (MCO) was synthesized as the anode material for lithium-ion batteries. Under basic conditions and using a molar ratio of OH- /NO3-= 1.5, crystallite size of 14 nm was found for samples calcined at 350°C. The electrodes were fabricated by mixing MCO as the active material, Super P carbon as the conducting material and polyvinylidene fluoride (PVDF) as the binder in N-methyl-2-pyrrolidone (NMP) solvent. The slurry was coated onto a copper foil substrate. The aim of this investigation is the assessment of deposition parameters on different plausible defects (such as agglomeration/blisters, pinholes/divots, cracks and non-uniform coating) and also electrical behavior of the deposited layer. Because of high degree of agglomeration, mortar method was found to be ineffective while mixing using magnetic stirrer was proved to be more appropriate in terms of final rheology. The optimum value for the binder was found to be 2.73 wt% of the NMP solvent. Effective drying was achieved using hotplate followed by oven drying. SEM analysis revealed the disappearance of the surface cracks when samples are pressed after drying stage.

The formation of novel layered compounds by exfoliation and restacking of cadmium phosphorus trisulphide with the biological molecules adenosine monophosphate and cytidine monophosphate included

NASA Astrophysics Data System (ADS)

Westreich, Philippe

2004-12-01

Exfoliated single layer Cd0.8PS3 has been combined with the biological molecules cytidine monophosphate (CMP) and adenosine monophosphate (AMP) to form the novel restacked compound LixCd 0.8PS3(NMP)z(H2O) y, where N stands for cytidine or adenosine. Composition was determined using energy dispersive X-ray spectroscopy, and the structure of these compounds was studied using X-ray diffraction on oriented films. It was found that for the AMP samples, there is little influence of relative humidity (RH) in the range of 0 to 80%, after which there is a rapid expansion of the interlayer space. In the 0 to 80% range, for (AMP)0.5, a host plane spacing near 19.6 A was found. Electron density calculations on the X-ray diffraction pattern suggest a model for the arrangement of guest AMP molecules between the host layers, with an accompanying water molecule. The calculations also suggest that there is a buckling in the host layer of about +/-0.6 A. For the (CMP)0.3 samples, there is more sensitivity to relative humidity in the 0--80% range, with spacings varying from 20 to 24 A. Much of this variation is gradual, but at around 50% RH, there is a discontinous change in the spacing of about 1.8 A, corresponding to less than the size of a water molecule, that appears to arise from a modification of the CMP conformation. Possible reasons far the differences in the behaviour of the two systems are explored.

Maximizing PTH Anabolic Osteoporosis Therapy. Revision

DTIC Science & Technology

2016-09-01

Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited...SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick...mono-therapy and PTH+ anti-catabolic combination therapies on Nmp4-/- and wild type (WT) mice. The scope of the research comprises the following

Stability of SG1 nitroxide towards unprotected sugar and lithium salts: a preamble to cellulose modification by nitroxide-mediated graft polymerization

PubMed Central

Moreira, Guillaume; Charles, Laurence; Major, Mohamed; Vacandio, Florence; Guillaneuf, Yohann

2013-01-01

Summary The range of applications of cellulose, a glucose-based polysaccharide, is limited by its inherently poor mechanical properties. The grafting of synthetic polymer chains by, for example, a “grafting from” process may provide the means to broaden the range of applications. The nitroxide-mediated polymerization (NMP) method is a technique of choice to control the length, the composition and the architecture of the grafted copolymers. Nevertheless, cellulose is difficult to solubilize in organic media because of inter- and intramolecular hydrogen bonds. One possibility to circumvent this limitation is to solubilize cellulose in N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMA) with 5 to 10 wt % of lithium salts (LiCl or LiBr), and carry out grafted polymerization in this medium. The stability of nitroxides such as SG1 has not been studied under these conditions yet, even though these parameters are of crucial importance to perform the graft modification of polysaccharide by NMP. The aim of this work is to offer a model study of the stability of the SG1 nitroxide in organic media in the presence of unprotected glucose or cellobiose (used as a model of cellulose) and in the presence of lithium salts (LiBr or LiCl) in DMF or DMA. Contrary to TEMPO, SG1 proved to be stable in the presence of unprotected sugar, even with an excess of 100 molar equivalents of glucose. On the other hand, lithium salts in DMF or DMA clearly degrade SG1 nitroxide as proven by electron-spin resonance measurements. The instability of SG1 in these lithium-containing solvents may be explained by the acidification of the medium by the hydrolysis of DMA in the presence of LiCl. This, in turn, enables the disproportionation of the SG1 nitroxide into an unstable hydroxylamine and an oxoammonium ion. Once the conditions to perform an SG1-based nitroxide-mediated graft polymerization from cellobiose have been established, the next stage of this work will be the modification of cellulose and cellulose derivatives by NMP. PMID:23946859

Synthesis of a Chloroamide-Hyperbranched Polymer Additive for Self-Decontaminating Surfaces

DTIC Science & Technology

2012-04-01

dissolved in dichloromethane (DCM) (30 mL) and the solution was dried with anhydrous sodium sulfate (Na2SO4) before being used in the next step...infrared spectroscopy N2 nitrogen Na2SO4 anhydrous sodium sulfate NMP 1-methyl-2-pyrrolidinone PFOA perfluorinated octanoic acid PMMA poly(methyl...16 3.6.1 Synthesis and Characterization of Chlorinated 5,5-Dimethylhydantoin Sodium Salt

Lateral diffusion study of the Pt-Al system using the NAC nuclear microprobe.

NASA Astrophysics Data System (ADS)

de Waal, H.; Pretorius, R.

1999-10-01

In this study a nuclear microprobe (NMP) was used to analyse phase formation during reaction in Pt-Al lateral diffusion couples. Phase identification was done by Rutherford backscattering spectroscopy. These results were compared with phase formation during conventional thin film Pt-Al interactions. The co-existence of multiple phases in lateral diffusion couples is discussed with reference to the effective heat of formation (EHF) model.

Partial dissolution of ACQ-treated wood in lithium chloride/N-methyl-2-pyrrolidinone: Separation of copper from potential lignocellulosic feedstocks

Treesearch

Thomas L. Eberhardt; Stan Lebow; Karen G. Reed

2012-01-01

A cellulose solvent system based on lithium chloride (LiCl) in N-methyl-2-pyrrolidinone (NMP) was used to assess the merits of partial dissolutions of coarsely ground wood samples. Alkaline Copper Quaternary (ACQ)-treated pine wood was of particular interest for treatment given the potential to generate a copper- rich stream apart from solid and/or liquid...

Microbial enumeration of different functional groups and bacterial behavior in acid basic conditions of a biotoxic landfill leachate of Bahía Blanca, Argentina.

PubMed

Yunes, Fabiana; Baldini, Mónica D; Gómez, Marisa A

2009-05-01

Leachate is liquid waste from refuse biological decomposition or rainwater percolation in a landfill. This research focused on leachate produced by a landfill in Bahia Blanca, Buenos Aires, Argentina. The research studied the main microbial populations involved in wastewater treatment, analyzed the behavior of bacteria isolated from leachate at different pH values, and appraised leachate biotoxicity. The number of bacteria varied by type, ranging from 1 x 10(4) to 1 x 10(5) CUF/mL aerobic heterotrophic bacteria (AHB); 1 x 10(3) to 1 x 10(5) CUF/mL anaerobic heterotrophic bacteria (ANHB); 1 x 10(5) to 1 x 10(6) CUF/mL sulfite-reducing bacteria (SRB); 1 x 10(3) to 1 x 10(6) NMP/mL nitrate-reducing bacteria (NRB); and 1 x 10(2) to 1 x 10(4) NMP/mL ammonium-oxidizing bacteria (AOB). Several microbial strains developed at pH 5, 7, and 10. These pH values changed to 9 in the culture media after a 48-hour incubation. Leachate was used to water lettuce seeds (Lactuca sativa capitata). Its toxicity was proved by full inhibition of plant development.

Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems.

PubMed

Liu, Hui; Venkatraman, Subbu S

2012-05-01

Although injectable depot-forming solutions have been commercialized, the factors that influence the overall release kinetics from such systems are still not fully understood. In this work, we address the effect of cosolvent on the issue of excessive burst release of potent bioactives from injectable depot-forming solutions. Specifically, we have evaluated the influence of addition of a relatively hydrophobic cosolvent (triacetin) to more hydrophilic biocompatible solvents such as dimethyl sulfoxide (DMSO) and N-methyl-2-pyrrolidone (NMP) on the burst release. Drug release and solvent release results demonstrate that high burst release that occurred when only hydrophilic solvent was used as solvent was significantly reduced by adding triacetin as a cosolvent. The profiles of drug release were in good agreement with the profiles of the hydrophilic solvent DMSO or NMP release, and the suppression of the burst by triacetin addition is due to the suppression of the solvent release. Surprisingly, the swelling of the depot increased with triacetin amount and the depot morphology became more porous compared with the absence of triacetin. Usage of hydrophobic solvent as a cosolvent to reduce the burst release was shown to be more effective on the hydrophobic PdlLA depot and less effective on the relatively hydrophilic RG502 depot. Copyright © 2012 Wiley Periodicals, Inc.

Retrospective Cost Adaptive Control with Concurrent Closed-Loop Identification

NASA Astrophysics Data System (ADS)

Sobolic, Frantisek M.

Retrospective cost adaptive control (RCAC) is a discrete-time direct adaptive control algorithm for stabilization, command following, and disturbance rejection. RCAC is known to work on systems given minimal modeling information which is the leading numerator coefficient and any nonminimum-phase (NMP) zeros of the plant transfer function. This information is normally needed a priori and is key in the development of the filter, also known as the target model, within the retrospective performance variable. A novel approach to alleviate the need for prior modeling of both the leading coefficient of the plant transfer function as well as any NMP zeros is developed. The extension to the RCAC algorithm is the use of concurrent optimization of both the target model and the controller coefficients. Concurrent optimization of the target model and controller coefficients is a quadratic optimization problem in the target model and controller coefficients separately. However, this optimization problem is not convex as a joint function of both variables, and therefore nonconvex optimization methods are needed. Finally, insights within RCAC that include intercalated injection between the controller numerator and the denominator, unveil the workings of RCAC fitting a specific closed-loop transfer function to the target model. We exploit this interpretation by investigating several closed-loop identification architectures in order to extract this information for use in the target model.

Thermostability of Hybrid Thermoelectric Materials Consisting of Poly(Ni-ethenetetrathiolate), Polyimide and Carbon Nanotubes

PubMed Central

Oshima, Keisuke; Sadakata, Shifumi; Shiraishi, Yukihide; Toshima, Naoki

2017-01-01

Three-component organic/inorganic hybrid films were fabricated by drop-casting the mixed dispersion of nanodispersed-poly(nickel 1,1,2,2-ethenetetrathiolate) (nano-PETT), polyimide (PI) and super growth carbon nanotubes (SG-CNTs) in N-methylpyrrolidone (NMP) at the designed ratio on a substrate. The dried nano-PETT/PI/SG-CNT hybrid films were prepared by the stepwise cleaning of NMP and methanol, and were dried once more. The thermoelectric properties of Seebeck coefficient S and electrical conductivity σ were measured by a thin-film thermoelectric measurement system ADVANCE RIKO ZEM-3M8 at 330–380 K. The electrical conductivity of nano-PETT/PI/SG-CNT hybrid films increased by 1.9 times for solvent treatment by clearing insulated of polymer. In addition, the density of nano-PETT/PI/SG-CNT hybrid films decreased 1.31 to 0.85 g·cm−3 with a decrease in thermal conductivity from 0.18 to 0.12 W·m−1·K−1. To evaluate the thermostability of nano-PETT/PI/SG-CNT hybrid films, the samples were kept at high temperature and the temporal change of thermoelectric properties was measured. The nano-PETT/PI/SG-CNT hybrid films were rather stable at 353 K and kept their power factor even after 4 weeks. PMID:28773182

The thermoregulatory mechanism of melatonin-induced hypothermia in chicken.

PubMed

Rozenboim, I; Miara, L; Wolfenson, D

1998-01-01

The involvement of melatonin (Mel) in body temperature (Tb) regulation was studied in White Leghorn layers. In experiment 1, 35 hens were injected intraperitoneally with seven doses of Mel (0, 5, 10, 20, 40, 80, or 160 mg Mel/kg body wt) dissolved in ethanol. Within 1 h, Mel had caused a dose-dependent reduction in Tb. To eliminate a possible vehicle effect, 0, 80, and 160 mg/kg body wt Mel dissolved in N-methyl-2-pyrrolidone (NMP) was injected. NMP had no effect on Tb, with Mel again causing a dose-dependent hypothermia. In experiment 2 (n = 30), Mel injected before exposure of layers to heat reduced Tb and prevented heat-induced hyperthermia. Injection after heat stress had begun did not prevent hyperthermia. Under cold stress, Mel induced hypothermia, which was not observed in controls. In experiment 3 (n = 12), Mel injection reduced Tb and increased metatarsal and comb temperatures (but not feathered-skin temperature), respiratory rate, and evaporative water loss. Heart rate rose and then declined, and blood pressure increased 1 h after Mel injection. Heat production rose slightly during the first hour, then decreased in parallel to the Tb decline. We conclude that pharmacological doses of Mel induce hypothermia in hens by increasing nonevaporative skin heat losses and slightly increasing respiratory evaporation.

Survey of German non-medical practitioners regarding complementary and alternative medicine in oncology.

PubMed

Koehl, Benjamin; Muenstedt, Karsten; Micke, Oliver; Muecke, Ralph; Buentzel, Jens; Stoll, Christoph; Prott, Franz Josef; Dennert, Gabriele; Senf, Bianca; Huebner, Jutta

2014-01-01

In total, 40-70% of cancer patients use complementary or alternative medicine (CAM). Many of them ask for advice from non-medical practitioners (NMPs). Our aim was to investigate the attitude of NMPs regarding their treatments for cancer patients. A survey was performed on members of NMP associations, using an online questionnaire on diagnosis and treatment, goals for using CAM, communication with the oncologist, and sources of information. Of the 1,500 members of the NMP associations, 299 took part. The treatments were found to be heterogeneous. Homeopathy is used by 45% of the NMPs; 10% believe it to be a treatment directly against cancer. Herbal therapy, vitamins, orthomolecular medicine, ordinal therapy, mistletoe preparations, acupuncture, and cancer diets are used by more than 10% of the NMPs. None of the treatments is discussed with the respective physician on a regular basis. Many therapies provided by NMPs are biologically based and therefore may interfere with conventional cancer therapy. Thus, patients are at risk of interactions, especially as most NMPs do not adjust their therapies to those of the oncologist. Moreover, risks may arise from these CAM methods as NMPs partly believe them to be useful anticancer treatments. This may lead to the delay or even omission of effective therapies. © 2014 S. Karger GmbH, Freiburg.

Prospects for reducing the processing cost of lithium ion batteries

DOE PAGES

Wood III, David L.; Li, Jianlin; Daniel, Claus

2014-11-06

A detailed processing cost breakdown is given for lithium-ion battery (LIB) electrodes, which focuses on: elimination of toxic, costly N-methylpyrrolidone (NMP) dispersion chemistry; doubling the thicknesses of the anode and cathode to raise energy density; and, reduction of the anode electrolyte wetting and SEI-layer formation time. These processing cost reduction technologies generically adaptable to any anode or cathode cell chemistry and are being implemented at ORNL. This paper shows step by step how these cost savings can be realized in existing or new LIB manufacturing plants using a baseline case of thin (power) electrodes produced with NMP processing and amore » standard 10-14-day wetting and formation process. In particular, it is shown that aqueous electrode processing can cut the electrode processing cost and energy consumption by an order of magnitude. Doubling the thickness of the electrodes allows for using half of the inactive current collectors and separators, contributing even further to the processing cost savings. Finally wetting and SEI-layer formation cost savings are discussed in the context of a protocol with significantly reduced time. These three benefits collectively offer the possibility of reducing LIB pack cost from $502.8 kWh-1-usable to $370.3 kWh-1-usable, a savings of $132.5/kWh (or 26.4%).« less

Deposition of functional nanoparticle thin films by resonant infrared laser ablation.

NASA Astrophysics Data System (ADS)

Haglund, Richard; Johnson, Stephen; Park, Hee K.; Appavoo, Kannatessen

2008-03-01

We have deposited thin films containing functional nanoparticles, using tunable infrared light from a picosecond free-electron laser (FEL). Thin films of the green light-emitting molecule Alq3 were first deposited by resonant infrared laser ablation at 6.68 μm, targeting the C=C ring mode of the Alq3. TiO2 nanoparticles 50-100 nm diameter were then suspended in a water matrix, frozen, and transferred by resonant infrared laser ablation at 2.94 μm through a shadow mask onto the Alq3 film. Photoluminescence was substantially enhanced in the regions of the film covered by the TiO2 nanoparticles. In a second experiment, gold nanoparticles with diameters in the range of 50-100 nm were suspended in the conducting polymer and anti-static coating material PEDOT:PSS, which was diluted by mixing with N-methyl pyrrolidinone (NMP). The gold nanoparticle concentration was 8-10% by weight. The mixture was frozen and then ablated by tuning the FEL to 3.47 μm, the C-H stretch mode of NMP. Optical spectroscopy of the thin film deposited by resonant infrared laser ablation exhibited the surface-plasmon resonance characteristic of the Au nanoparticles. These experiments illustrate the versatility of matrix-assisted resonant infrared laser ablation as a technique for depositing thin films containing functionalized nanoparticles.

Systems Architecture for Fully Autonomous Space Missions

NASA Technical Reports Server (NTRS)

Esper, Jamie; Schnurr, R.; VanSteenberg, M.; Brumfield, Mark (Technical Monitor)

2002-01-01

The NASA Goddard Space Flight Center is working to develop a revolutionary new system architecture concept in support of fully autonomous missions. As part of GSFC's contribution to the New Millenium Program (NMP) Space Technology 7 Autonomy and on-Board Processing (ST7-A) Concept Definition Study, the system incorporates the latest commercial Internet and software development ideas and extends them into NASA ground and space segment architectures. The unique challenges facing the exploration of remote and inaccessible locales and the need to incorporate corresponding autonomy technologies within reasonable cost necessitate the re-thinking of traditional mission architectures. A measure of the resiliency of this architecture in its application to a broad range of future autonomy missions will depend on its effectiveness in leveraging from commercial tools developed for the personal computer and Internet markets. Specialized test stations and supporting software come to past as spacecraft take advantage of the extensive tools and research investments of billion-dollar commercial ventures. The projected improvements of the Internet and supporting infrastructure go hand-in-hand with market pressures that provide continuity in research. By taking advantage of consumer-oriented methods and processes, space-flight missions will continue to leverage on investments tailored to provide better services at reduced cost. The application of ground and space segment architectures each based on Local Area Networks (LAN), the use of personal computer-based operating systems, and the execution of activities and operations through a Wide Area Network (Internet) enable a revolution in spacecraft mission formulation, implementation, and flight operations. Hardware and software design, development, integration, test, and flight operations are all tied-in closely to a common thread that enables the smooth transitioning between program phases. The application of commercial software development techniques lays the foundation for delivery of product-oriented flight software modules and models. Software can then be readily applied to support the on-board autonomy required for mission self-management. An on-board intelligent system, based on advanced scripting languages, facilitates the mission autonomy required to offload ground system resources, and enables the spacecraft to manage itself safely through an efficient and effective process of reactive planning, science data acquisition, synthesis, and transmission to the ground. Autonomous ground systems in turn coordinate and support schedule contact times with the spacecraft. Specific autonomy software modules on-board include mission and science planners, instrument and subsystem control, and fault tolerance response software, all residing within a distributed computing environment supported through the flight LAN. Autonomy also requires the minimization of human intervention between users on the ground and the spacecraft, and hence calls for the elimination of the traditional operations control center as a funnel for data manipulation. Basic goal-oriented commands are sent directly from the user to the spacecraft through a distributed internet-based payload operations "center". The ensuing architecture calls for the use of spacecraft as point extensions on the Internet. This paper will detail the system architecture implementation chosen to enable cost-effective autonomous missions with applicability to a broad range of conditions. It will define the structure needed for implementation of such missions, including software and hardware infrastructures. The overall architecture is then laid out as a common thread in the mission life cycle from formulation through implementation and flight operations.

Development of a Modeling Framework to Support Control Investigations of Sailcraft Missions A First Cut: ABLE Sailcraft Dynamics Model

NASA Technical Reports Server (NTRS)

Sarathy, Sriprakash

2005-01-01

Solar Sailcraft, the stuff of dreams of the H.G. Wells generation, is now a rapidly maturing reality. The promise of unlimited propulsive power by harnessing stellar radiation is close to realization. Currently, efforts are underway to build, prototype and test two configurations. These sails are designed to meet a 20m sail requirement, under guidance of the In-Space Propulsion (ISP) technology program office at MSFC. While these sails will not fly , they are the first steps in improving our understanding of the processes and phenomena at work. As part of the New Millennium Program (NMP) the ST9 technology validation mission hopes to launch and fly a solar sail by 2010 or sooner. Though the Solar Sail community has been studying and validating various concepts over two decades, it was not until recent breakthroughs in structural and material technology, has made possible to build sails that could be launched. With real sails that can be tested (albeit under earth conditions), the real task of engineering a viable spacecraft has finally commenced. Since it is not possible to accurately or practically recreate the actual operating conditions of the sailcraft (zero-G, vacuum and extremely low temperatures), much of the work has focused on developing accurate models that can be used to predict behavior in space, and for sails that are 6-10 times the size of currently existing sails. Since these models can be validated only with real test data under "earth" conditions, the process of modeling and the identification of uncertainty due to model assumptions and scope need to be closely considered. Sailcraft models that exist currently, are primarily focused on detailed physical representations at the component level, these are intended to support prototyping efforts. System level models that cut across different sail configurations and control concepts while maintaining a consistent approach are non-existent. Much effort has been focused on the areas of thrust performance, solar radiation prediction, and sail membrane behavior vis-a-vis their reflective geometry, such as wrinkling/folding/furling as it pertains to thrust prediction. A parallel effort has been conducted on developing usable models for developing attitude control systems (ACS), for different sail configurations in different regimes. There has been very little by way of a system wide exploration of the impact of the various control schemes, thrust prediction models for different sail configurations being considered.

Maximizing PTH Anabolic Osteoporosis Therapy

DTIC Science & Technology

2014-09-01

PTH- stimulated addition of trabecular bone at 3 weeks of hor- mone treatment, and that Nmp4 has a profound regulatory role in BM population dynamics...Qin L, LJ Raggatt, and Partridge. (2004). Parathyroid hor- mone : a double-edged sword for bone metabolism. Trends Endocrinol Metab 15:60–65. 14. Kular...parathyroid hor- mone administration is due to the stimulation of prolifera- tion and differentiation of osteoprogenitor cells in BM. Bone 15:717–723. 16

Fabrication and Optimization of Carbon Nanomaterial-Based Lithium-Ion Battery Anodes

DTIC Science & Technology

2012-03-01

preparation setup under the fume hood with NMP solvent, glass pipette with dispenser, and the ball milled powder mixture containing LiFePO4 , acetylene...minutes. ............................................................................. 18 Figure 12. (a) LiFePO4 slurry applied on foil current collector...and (b) LiFePO4 slurry casted with applicator and (c) LiFePO4 casted (From [15])....... 18 Figure 13. MTI disc cutter used to cut individual

Design, Synthesis of Novel Lipids as Chemical Permeation Enhancers and Development of Nanoparticle System for Transdermal Drug Delivery

PubMed Central

Shah, Punit P.; Etukala, Jagan Reddy; Vemuri, Adithi; Singh, Mandip

2013-01-01

In the present study, we designed and developed novel lipids that include (Z)-1-(Octadec-9-en-1-yl)-pyrrolidine (Cy5T), 1, 1-Di-((Z)-octadec-9-en-1-yl)pyrrolidin-1-ium iodide (Cy5), (Z)-1-(Octadec-9-en-1-yl)-piperidine (Cy6T), and 1, 1-Di-((Z)-octadec-9-en-1-yl) piperidin-1-ium iodide (Cy6) to enhance the transdermal permeation of some selected drugs. Firstly, we evaluated the transdermal permeation efficacies of these lipids as chemical permeation enhancers in vehicle formulations for melatonin, ß-estradiol, caffeine, α-MSH, and spantide using franz diffusion cells. Among them Cy5 lipid was determined to be the most efficient by increasing the transdermal permeation of melatonin, ß-estradiol, caffeine, α-MSH, and spantide by 1.5 to 3.26-fold more at the epidermal layer and 1.3 to 2.5-fold more at the dermal layer, in comparison to either NMP or OA. Hence we developed a nanoparticle system (cy5 lipid ethanol drug nanoparticles) to evaluate any further improvement in the drug penetration. Cy5 lipid formed uniformly sized nanoparticles ranging from 150–200 nm depending on the type of drug. Further, Cy5 based nanoparticle system significantly (p<0.05) increased the permeation of all the drugs in comparison to the lipid solution and standard permeation enhancers. There were about 1.54 to 22-fold more of drug retained in the dermis for the Cy5 based nanoparticles compared to OA/NMP standard enhancers and 3.87 to 66.67-fold more than lipid solution. In addition, epifluorescent microscopic analysis in rhodamine-PE permeation studies confirmed the superior permeation enhancement of LEDs (detection of fluorescence up to skin depth of 340 μm) more than lipid solution, which revealed fluorescence up to skin depth of only 260 μm. In summary the present findings demonstrate that i) cationic lipid with 5 membered amine heterocyclic ring has higher permeating efficacy than the 6 membered amine hertocyclic ring. ii) The nanoparticle system prepared with Cy5 showed significant (p<0.05) increase in the permeation of the drugs than the control penetration enhancers, oleic acid and NMP. PMID:24349315

An Ultrastable Europium(III)-Organic Framework with the Capacity of Discriminating Fe2+/Fe3+ Ions in Various Solutions.

PubMed

Wen, Guo-Xuan; Wu, Ya-Pan; Dong, Wen-Wen; Zhao, Jun; Li, Dong-Sheng; Zhang, Jian

2016-10-05

An ultrastable luminescent europium-organic framework, {[Eu(L)(H 2 O) 2 ]·NMP·H 2 O} n (CTGU-2; NMP = N-methyl-2-pyrrolidone), can first detect Fe 2+ /Fe 3+ cations in different medium systems with high selectivity and sensitivity, and it also exhibits high sensitivity for Cr 2 O 7 2- anion and acetone with a wide linear range and a low detection limit.

Maturation and sexual ontogeny in the spangled emperor Lethrinus nebulosus.

PubMed

Marriott, R J; Jarvis, N D C; Adams, D J; Gallash, A E; Norriss, J; Newman, S J

2010-04-01

The reproductive development and sexual ontogeny of spangled emperor Lethrinus nebulosus populations in the Ningaloo Marine Park (NMP) were investigated to obtain an improved understanding of its evolved reproductive strategy and data for fisheries management. Evidence derived from (1) analyses of histological data and sampled sex ratios with size and age, (2) the identification of residual previtellogenic oocytes in immature and mature testes sampled during the spawning season and (3) observed changes in testis internal structure with increasing fish size and age, demonstrated a non-functional protogynous hermaphroditic strategy (or functional gonochorism). All the smallest and youngest fish sampled were female until they either changed sex to male at a mean 277.5 mm total length (L(T)) and 2.3 years old or remained female and matured at a larger mean L(T) (392.1 mm) and older age (3.5 years). Gonad masses were similar for males and females over the size range sampled and throughout long reproductive lives (up to a maximum estimated age of c. 31 years), which was another correlate of functional gonochorism. That the mean L(T) at sex change and female maturity were below the current minimum legal size (MLS) limit (410 mm) demonstrated that the current MLS limit is effective for preventing recreational fishers in the NMP retaining at least half of the juvenile males and females in their landed catches.

Porous Polyimide Membranes Prepared by Wet Phase Inversion for Use in Low Dielectric Applications

PubMed Central

Kim, Soohyun; Jang, Keon-Soo; Choi, Hee-Dok; Choi, Seung-Hoon; Kwon, Seong-Ji; Kim, Il-Doo; Lim, Jung Ah; Hong, Jae-Min

2013-01-01

A wet phase inversion process of polyamic acid (PAA) allowed fabrication of a porous membrane of polyimide (PI) with the combination of a low dielectric constant (1.7) and reasonable mechanical properties (Tensile strain: 8.04%, toughness: 3.4 MJ/m3, tensile stress: 39.17 MPa, and young modulus: 1.13 GPa), with further thermal imidization process of PAA. PAA was simply synthesized from purified pyromellitic dianhydride (PMDA) and 4,4-oxydianiline (ODA) in two different reaction solvents such as γ-butyrolactone (GBL) and N-methyl-2-pyrrolidinone (NMP), which produce Mw/PDI of 630,000/1.45 and 280,000/2.0, respectively. The porous PAA membrane was fabricated by the wet phase inversion process based on a solvent/non-solvent system via tailored composition between GBL and NMP. The porosity of PI, indicative of a low electric constant, decreased with increasing concentration of GBL, which was caused by sponge-like formation. However, due to interplay between the low electric constant (structural formation) and the mechanical properties, GBL was employed for further exploration, using toluene and acetone vs. DI-water as a coagulation media. Non-solvents influenced determination of the PAA membrane size and porosity. With this approach, insight into the interplay between dielectric properties and mechanical properties will inform a wide range of potential low-k material applications. PMID:23615465

High performance screen-printed electrodes prepared by a green solvent approach for lithium-ion batteries

NASA Astrophysics Data System (ADS)

Gören, A.; Mendes, J.; Rodrigues, H. M.; Sousa, R. E.; Oliveira, J.; Hilliou, L.; Costa, C. M.; Silva, M. M.; Lanceros-Méndez, S.

2016-12-01

New inks based on lithium iron phosphate and graphite for cathode and anode, respectively, were developed for printable lithium-ion batteries using the "green solvent" N,N‧-dimethylpropyleneurea (DMPU) and poly(vinylidene fluoride), PVDF, as a binder. The results were compared with the ones from inks developed with the conventionally used solvent N-methyl-2-pyrrolidone, NMP. The rheological properties of the PVDF/DMPU binder solution shows a more pronounced shear thinning behavior than the PVDF/NMP solution. Cathode inks prepared with 2.25 mL and 2.50 mL of DMPU for 1 g of electrode mass show an apparent viscosity of 3 Pa s and 2 Pa s for a shear rate of 100 s-1, respectively, being therefore processable by screen-printing or doctor blade techniques. The electrodes prepared with DMPU and processed by screen-printing show a capacity of 52 mAh g-1 at 2C for the cathode and 349 mAh g-1 at C/5 for the anode, after 45 charge-discharge cycles. The electrochemical performance of both electrodes was evaluated in a full-cell and after 9 cycles, the discharge capacity value is 81 mAh g-1, showing a discharge capacity retention of 64%. The new inks presented in this work are thus suitable for the development of printed batteries and represent a step forward towards more environmental friendly processes.

A multi-responsive luminescent sensor based on a super-stable sandwich-type terbium(iii)-organic framework.

PubMed

Wen, Guo-Xuan; Han, Min-Le; Wu, Xue-Qian; Wu, Ya-Pan; Dong, Wen-Wen; Zhao, Jun; Li, Dong-Sheng; Ma, Lu-Fang

2016-10-04

A super-stable multifunctional terbium(iii)-organic framework, namely {[Tb(TATAB) (H 2 O) 2 ]·NMP·H 2 O} n (Tb-MOF, H 3 TATAB = 4,4',4''-s-triazine-1,3,5-triyltri-m-aminobenzoic acid, NMP = N-methyl-2-pyrrolidone) was synthesized. Tb-MOF exhibits a 2D sql structure with binuclear [Tb 2 (COO) 4 (H 2 O) 4 ] 2+ units as 4-connected nodes, and free water and NMP molecules are inserted between 2D layers through hydrogen-bonding interactions, forming a sandwich-type architecture. Observably, such a framework remains intact in a remarkable variety of environments such as common solvents and aqueous solutions with metal cations and inorganic anions, as well as with a pH ranging from 1 to 13. In particular, Tb-MOF can not only detect small organic molecules, metal cations and inorganic anions with high sensitivity and high selectivity, but also can accurately detect explosive 2-nitrophenol, 3-nitrophenol, 4-nitrophenol and 2,4,6-trinitrophenol in water. Its luminescence quenching response to Fe 3+ and Cr 2 O 7 2- ions can be explained in terms of the competitive absorption mechanism. In addition, the luminescence intensity of Tb-MOF is strongly correlated with the pH value in a pH range from 1 to 13. Thus, this material can be potentially used as a multi-responsive luminescent sensor.

Capsaicin modulates acetylcholine release at the myoneural junction.

PubMed

Thyagarajan, Baskaran; Potian, Joseph G; Baskaran, Padmamalini; McArdle, Joseph J

2014-12-05

Transient receptor potential (TRP) proteins are non-selective cation channel proteins that are expressed throughout the body. Previous studies demonstrated the expression of TRP Vanilloid 1 (TRPV1), capsaicin (CAP) receptor, in sensory neurons. Recently, we reported TRPV1 expression in mouse motor nerve terminals [MNTs; (Thyagarajan et al., 2009)], where we observed that CAP protected MNTs from botulinum neurotoxin A (BoNT/A). Phrenic nerve diaphragm nerve muscle preparations (NMP) isolated from isoflurane anesthetized adult mice were analyzed for twitch tension, spontaneous (mEPCs) and nerve stimulus evoked (EPCs) acetylcholine release. When acutely applied to isolated NMP, CAP produced a concentration-dependent decline of twitch tension and produced a significant decline in the amplitude of EPCs and quantal content without any effect on the mEPCs. The suppression of nerve stimulus evoked acetylcholine release by CAP was antagonized by capsazepine (CPZ), a TRPV1 antagonist. CAP did not suppress phrenic nerve stimulus evoked acetylcholine release in TRPV1 knockout mice. Also, CAP treatment, in vitro, interfered with the localization of adapter protein 2 in cholinergic Neuro 2a cells. Wortmannin, (WMN; non-selective phosphoinositol kinase inhibitor), mimicked the effects of CAP by inhibiting the acetylcholine exocytosis. Our data suggest that TRPV1 proteins expressed at the MNT are coupled to the exo-endocytic mechanisms to regulate neuromuscular functions. Copyright © 2014 Elsevier B.V. All rights reserved.

Preparation and characterization of nanocomposite polymer electrolytes poly(vinylidone fluoride)/nanoclay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahmawati, Suci A.; Sulistyaningsih,; Putro, Alviansyah Z. A.

2016-02-08

Polymer electrolytes are defined as semi solid electrolytes used as separator in lithium ion battery. Separator used as medium for transfer ions and to prevent electrical short circuits in battery cells. To obtain the optimal battery performance, separator with high porosity and electrolyte uptake is required. This can reduce the resistance in the transfer of ions between cathode and anode. The main objective of this work is to investigate the impact of different solvent (Dimethyl acetamide (DMAc), N-methyl-2-pyrrolidone (NMP) and dimethyl formamide (DMF)), pore forming agent poly(vinylpyrolidone) (PVP) and nanoclay as filler in addition of membrane using phase inversion methodmore » on the morphology, porosity, electrolyte uptake and degree of crystallinity. The membrane was prepared by the phase inversion method by adding PVP and Nanoclay using different solvents. The phase inversion method was prepared by dissolving Nanoclay and PVP in solvent for 1-2 hours, and then add the PVDF with stirring for 4 hours at 60°C. The membranes were characterized by porosity test, electrolyte uptake test, scanning electron microscope (SEM), and X-ray diffraction (XRD). The results showed that DMAc as solvent gives the highest value of porosity and electrolyte uptake. The addition of nanoclay and PVP enlarge the size of the pores and reduce the degree of crystallinity. So, the usage of DMAc as solvent is better than NMP or DMF.« less

Injectable, in situ forming poly(propylene fumarate)-based ocular drug delivery systems.

PubMed

Ueda, H; Hacker, M C; Haesslein, A; Jo, S; Ammon, D M; Borazjani, R N; Kunzler, J F; Salamone, J C; Mikos, A G

2007-12-01

This study sought to develop an injectable formulation for long-term ocular delivery of fluocinolone acetonide (FA) by dissolving the anti-inflammatory drug and the biodegradable polymer poly(propylene fumarate) (PPF) in the biocompatible, water-miscible, organic solvent N-methyl-2-pyrrolidone (NMP). Upon injection of the solution into an aqueous environment, a FA-loaded PPF matrix is precipitated in situ through the diffusion/extraction of NMP into surrounding aqueous fluids. Fabrication of the matrices and in vitro release studies were performed in phosphate buffered saline at 37 degrees C. Drug loadings up to 5% were achieved. High performance liquid chromatography was employed to determine the released amount of FA. The effects of drug loading, PPF content of the injectable formulation, and additional photo-crosslinking of the matrix surface were investigated. Overall, FA release was sustained in vitro over up to 400 days. After an initial burst release of 22 to 68% of initial FA loading, controlled drug release driven by diffusion and bulk erosion was observed. Drug release rates in a therapeutic range were demonstrated. Release kinetics were found to be dependent on drug loading, formulation PPF content, and extent of surface crosslinking. The results suggest that injectable, in situ formed PPF matrices are promising candidates for the formulation of long-term, controlled delivery devices for intraocular drug delivery. Copyright 2007 Wiley Periodicals, Inc.

Design of a long-term antipsychotic in situ forming implant and its release control method and mechanism.

PubMed

Wang, Lexi; Wang, Aiping; Zhao, Xiaolei; Liu, Ximing; Wang, Dan; Sun, Fengying; Li, Youxin

2012-05-10

Two kinds of in situ forming implants (ISFIs) of atypical antipsychotics, risperidone and its 9-hydroxy active metabolite, paliperidone, using poly(lactide-co-glycolide)(PLGA) as carrier, were investigated. Significant difference was observed in the solution-gel transition mechanism of the two systems: homogeneous system of N-methyl-2-pyrrolidone (NMP) ISFI, in which drug was dissolved, and heterogeneous system of dimethyl sulfoxide (DMSO) ISFI, in which drug was dispersed. Fast solvent extractions were found in both systems, but in comparison with the high drug release rate from homogeneous system of drug/polymer/NMP, a fast solvent extraction from the heterogeneous system of drug/polymer/DMSO was not accompanied by a high drug release rate but a rapid solidification of the implant, which resulted in a high drug retention, well-controlled initial burst and slow release of the drug. In vivo study on beagle dogs showed a more than 3-week sustained release with limited initial burst. Pharmacologic evaluation on optimized paliperidone ISFIs presented a sustained-suppressing effect from 1 day to 38 day on the MK-801 induced schizophrenic behavior mice model. A long sustained-release antipsychotic ISFI of 50% drug loading and controlled burst release was achieved, which indicated a good potential in clinic application. Copyright © 2012 Elsevier B.V. All rights reserved.

Determination of 5-hydroxy-N-methyl-2-pyrrolidone and 2-hydroxy-N-methylsuccinimide in human plasma and urine using liquid chromatography-electrospray tandem mass spectrometry.

PubMed

Carnerup, M A; Akesson, B; Jönsson, B A

2001-09-15

A method for simultaneous determination of 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) was developed. These compounds are metabolites from N-methyl-2-pyrrolidone (NMP), a powerful and widely used organic solvent. 5-HNMP and 2-HMSI were purified from plasma and urine by solid-phase extraction using Isolute ENV+ columns, and analysed by liquid chromatography coupled to a mass spectrometer fitted with an atmospheric pressure turbo ion spray ionisation interface in the positive ion mode. The method was validated for plasma and urine concentrations from 0.12 to 25 microg/ml. The recoveries for 5-HNMP and 2-HMSI in plasma were 99 and 98%, respectively, and in urine 111 and 106%, respectively. For 5-HNMP and 2-HMSI, the within-day precision in plasma was 1-4 and 3-6%, respectively, and in urine 2-12 and 3-10%, respectively. The corresponding data for the between-day precision was 5 and 3-6%, respectively, and 4-6 and 7-8%, respectively. The detection limit for 5-HNMP was 4 ng/ml in plasma and 120 ng/ml in urine. For 2-HMSI, it was 5 ng/ml in plasma and 85 ng/ml in urine. The method is applicable for analysis of plasma and urine samples from workers exposed to NMP.

Assessment of toxicity and tolerability of a combination vehicle; 5% Pharmasolve, 45% Propylene glycol and 50% Polyethylene glycol 400 in rats following repeated intravenous administration.

PubMed

Pandey, Santosh Kumar; Goyal, Vinod Kumar; Nalge, Prashant; Are, Purnachander; Vincent, Sthevaan; Nirogi, Ramakrishna

2017-12-01

The selection of a suitable vehicle for administration of NCEs in non-clinical studies is always a challenge for poorly soluble compounds. Challenge is increased if the dose formulation is intended for intravenous (i.v.) administration where isotonic, biologically compatible pH and solution form is an absolute requirement. Vehicle toxicity and tolerability data are not readily available for a number of combination vehicles therefore, an i.v. tolerability studies was planned in rats with 5% v/v Pharmasolve (NMP), 45% v/v Propylene glycol (PG) and 50% v/v Polyethylene glycol (PEG) 400 combination, at dose volume of 0.5, 1, 2 and 5 mL/kg body weight for 28 days. The vehicle combination was administered via lateral tail vein and effects on clinical signs, body weights, feed consumption, clinical pathology and histopathology were evaluated. Clinical signs of toxicity like tremors, convulsions and death were noticed at 5 mL/kg during the course of the study. At 2 mL/kg, injection site injury without systemic toxicity was noticed. In conclusion, 1 mL/kg of a combination vehicle of 5% NMP, 45% PG and 55% PEG 400 can be administered intravenously once-a-day up to 28 days without any discomfort or injury to rats. Copyright © 2017 Elsevier Inc. All rights reserved.

Effect of Evaporation Time on Separation Performance of Polysulfone/Cellulose Acetate (PSF/CA) Membrane

NASA Astrophysics Data System (ADS)

Syahbanu, Intan; Piluharto, Bambang; Khairi, Syahrul; Sudarko

2018-01-01

Polysulfone and cellulose acetate are common material in separation. In this research, polysulfone/cellulose actetate (PSF/CA) blend membrane was prepared. The aim of this research was to study effect of evaporation time in casting of PSF/CA membrane and its performance in filtration. CA was obtained by acetylation process of bacterial cellulose (BC) from fermentation of coconut water. Fourier Transform Infra Red (FTIR) Spectroscopy was used to examine functional groups of BC, CA and commercial cellulose acetate. Subtitution of acetyl groups determined by titration method. Blend membranes were prepared through phase inversion technique in which composition of PSF/PEG/CA/NMP(%w) was 15/5/5/75. Polyethyleneglycol (PEG) and N-methyl-2-pyrrolidone (NMP) were act as pore forming agent and solvent, respectively. Variation of evaporation times were used as parameter to examine water uptake, flux, and morphology of PSF/CA blend membranes. FTIR spectra of CA show characteristic peak of acetyl group at 1220 cm-1 indicated that BC was acetylated succesfully. Degree of subtitution of BCA was found at 2.62. Highest water flux was performed at 2 bar obtained at 106.31 L.m-2.h-1 at 0 minute variation, and decrease as increasing evaporation time. Morphology of PSF/BCA blend membranes were investigated by Scanning Electron Microscopy (SEM) showed that porous asymetric membrane were formed.

[Tumor markers for bladder cancer: up-to-date study by the Kiel Tumor Bank].

PubMed

Hautmann, S; Eggers, J; Meyhoff, H; Melchior, D; Munk, A; Hamann, M; Naumann, M; Braun, P M; Jünemann, K P

2007-11-01

The number of noninvasive diagnostic tests for bladder cancer has increased tremendously over the last years with a large number of experimental and commercial tests. Comparative analyses of tests for diagnosis, follow-up, and recurrence detection of bladder cancer were performed retrospectively as well as prospectively, unicentrically, and multicentrically. An analysis of multicentric studies with large patient numbers compared with our own Kiel Tumor Bank data is presented. The Kiel Tumor Bank data looked prospectively at 106 consecutive bladder tumor patients from the year 2006. Special focus was put on urine cytology as a reference test, as well as the commercial NMP 22 Bladder Chek. The analysis of the NMP 22 Bladder Chek showed an overall sensitivity of 69% for all tumor grades and stages, with a specificity of 76%. Comparison to multicentric data with an overall sensitivity of 75% for all tumor grades and stages, with a specificity of 73%, showed results similar to those in the literature. Urine cytology showed a comparable overall sensitivity of 73% for all tumor grades and stages, with a specificity of 80%. A large number of noninvasive tests for bladder cancer follow-up with reasonable sensitivity and specificity can currently be used. Because of limited numbers of prospective randomized multicentric studies, no single particular marker for bladder cancer screening can be recommended at this point in time.

Characterization of Antimicrobial Agent Loaded Eudragit RS Solvent Exchange-Induced In Situ Forming Gels for Periodontitis Treatment.

PubMed

Phaechamud, Thawatchai; Jantadee, Takron; Mahadlek, Jongjan; Charoensuksai, Purin; Pichayakorn, Wiwat

2017-02-01

Eudragit RS (ERS), a quaternary polyacrylate positively charged polymer, exhibits a very low permeability and swells in aqueous media independently of pH without dissolving. Owing to its high solubility in N-methyl pyrrolidone (NMP), it was interesting to apply as polymer matrix for solvent-exchanged in situ forming gel. The aim of this research was to prepare in situ forming gels from ERS to deliver the antimicrobial agents (doxycycline hyclate, metronidazole, and benzoyl peroxide) for periodontitis treatment. They were evaluated for viscosity and rheology, gel formation, syringeability, drug release, and antimicrobial activities. The solvent exchange between NMP and an external aqueous simulated gingival crevicular fluid stimulated the dissolved ERS transforming into the opaque rigid gel. Antimicrobial agent loaded ERS systems exhibited Newtonian flow with acceptable syringeability. The higher-loaded ERS promoted the more prolongation of drug release because of the retardation of water diffusion into the precipitated matrix. Antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis depended on type of drugs and test microorganisms. Doxycycline hyclate loaded ERS systems showed these activities greater than the others; however, all of them could inhibit all test microorganisms. Thus, the solvent exchange-induced in situ forming gels comprising ERS-antimicrobial drugs exhibited potential use as localized delivery systems for periodontitis treatment.

Thermally stable booster explosive and process for manufacture

DOEpatents

Quinlin, William T [Amarillo, TX; Thorpe, Raymond [Amarillo, TX; Lightfoot, James M [Amarillo, TX

2006-03-21

A thermally stable booster explosive and process for the manufacture of the explosive. The product explosive is 2,4,7,9-tetranitro-10H-benzo[4,5]furo[3,2-b]indole (TNBFI). A reactant/solvent such as n-methylpyrrolidone (NMP) or dimethyl formamide (DMF) is made slightly basic. The solution is heated to reduce the water content. The solution is cooled and hexanitrostilbene is added. The solution is heated to a predetermined temperature for a specific time period, cooled, and the product is collected by filtration.

Development of Nanoporous Carbide-Derived Carbon Electrodes for High-Performance Lithium-Ion Batteries

DTIC Science & Technology

2011-09-01

carbon produced from TiC (From [10]). .................................... 27 Figure 9. LiFePO4 , acetylene black, and PVDF powders in weighing boat...dispenser, and the ball milled powder mixture x containing LiFePO4 , acetylene black, and PVDF binder; and b) Prepared slurry after adding NMP solvent to...the powder mixture. ..... 39 Figure 12. Sample vial containing a LiFePO4 slurry inside the ultrasonic bath. Each vial was sonicated for 30 minutes

Fluorinated graphene oxide for enhanced S and X-band microwave absorption

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sudeep, P. M.; TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad 500075; Vinayasree, S.

2015-06-01

Here we report the microwave absorbing properties of three graphene derivatives, namely, graphene oxide (GO), fluorinated GO (FGO, containing 5.6 at. % Fluorine (F)), and highly FGO (HFGO, containing 23 at. % F). FGO is known to be exhibiting improved electrochemical and electronic properties when compared to GO. Fluorination modifies the dielectric properties of GO and hence thought of as a good microwave absorber. The dielectric permittivities of GO, FGO, and HFGO were estimated in the S (2 GHz to 4 GHz) and X (8 GHz to 12 GHz) bands by employing cavity perturbation technique. For this, suspensions containing GO/FGO/HFGO were made in N-Methylmore » Pyrrolidone (NMP) and were subjected to cavity perturbation. The reflection loss was then estimated and it was found that −37 dB (at 3.2 GHz with 6.5 mm thickness) and −31 dB (at 2.8 GHz with 6 mm thickness) in the S band and a reflection loss of −18 dB (at 8.4 GHz with 2.5 mm thickness) and −10 dB (at 11 GHz with 2 mm thickness) in the X band were achieved for 0.01 wt. % of FGO and HFGO in NMP, respectively, suggesting that these materials can serve as efficient microwave absorbers even at low concentrations.« less

Determination of N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide in human urine and plasma.

PubMed

Jönsson, B A; Akesson, B

1997-12-19

A method for determination of N-methylsuccinimide (MSI) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in human urine and of MSI in human plasma was developed. MSI and 2-HMSI are metabolites of the widely used organic solvent N-methyl-2-pyrrolidone (NMP). MSI and 2-HMSI were purified from urine and plasma by C8 solid-phase extraction and analysed by gas chromatography-mass spectrometry in the negative-ion chemical ionisation mode. The intra-day precisions in urine were 2-6% for MSI (50 and 400 ng/ml) and 3-5% for 2-HMSI (1000 and 8000 ng/ml). For MSI in plasma it was 2% (60 and 1200 ng/ml). The between-day precisions in urine were 3-4% for MSI (100 and 1000 ng/ml) and 2-4% for 2-HMSI (10,000 and 18,000 ng/ml) and 3-4% for MSI in plasma (100 and 900 ng/ml). The recoveries from urine were 109-117% for MSI (50 and 400 ng/ml) and 81-89% for 2-HMSI (1000 and 8000 ng/ml). The recovery of MSI from plasma was 91-101% (50 and 500 ng/ml). The detection limits for MSI were 3 ng/ml in urine and 1 ng/ml in plasma and that of 2-HMSI in urine was 200 ng/ml. The method is applicable for analysis of urine and plasma samples from workers exposed to NMP.

Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors

PubMed Central

Cunningham, Thomas J.; Colas, Alexandre

2016-01-01

ABSTRACT Bipotent neuromesodermal progenitors (NMPs) residing in the caudal epiblast drive coordinated body axis extension by generating both posterior neuroectoderm and presomitic mesoderm. Retinoic acid (RA) is required for body axis extension, however the early molecular response to RA signaling is poorly defined, as is its relationship to NMP biology. As endogenous RA is first seen near the time when NMPs appear, we used WNT/FGF agonists to differentiate embryonic stem cells to NMPs which were then treated with a short 2-h pulse of 25 nM RA or 1 µM RA followed by RNA-seq transcriptome analysis. Differential expression analysis of this dataset indicated that treatment with 25 nM RA, but not 1 µM RA, provided physiologically relevant findings. The 25 nM RA dataset yielded a cohort of previously known caudal RA target genes including Fgf8 (repressed) and Sox2 (activated), plus novel early RA signaling targets with nearby conserved RA response elements. Importantly, validation of top-ranked genes in vivo using RA-deficient Raldh2−/− embryos identified novel examples of RA activation (Nkx1-2, Zfp503, Zfp703, Gbx2, Fgf15, Nt5e) or RA repression (Id1) of genes expressed in the NMP niche or progeny. These findings provide evidence for early instructive and permissive roles of RA in controlling differentiation of NMPs to neural and mesodermal lineages. PMID:27793834

Solvent-Induced Cadmium(II) Metal-Organic Frameworks with Adjustable Guest-Evacuated Porosity: Application in the Controllable Assembly of MOF-Derived Porous Carbon Materials for Supercapacitors.

PubMed

Yue, Man-Li; Jiang, Yi-Fan; Zhang, Lin; Yu, Cheng-Yan; Zou, Kang-Yu; Li, Zuo-Xi

2017-11-07

In this work, five new cadmium metal-organic frameworks (Cd-MOFs 1-5) have been synthesized from solvothermal reactions of Cd(NO 3 ) 2 ⋅4 H 2 O with isophthalic acid and 1,4-bis(imidazol-1-yl)-benzene under different solvent systems of CH 3 OH, C 2 H 5 OH, (CH 3 ) 2 CHOH, DMF, and N-methyl-2-pyrrolidone (NMP), respectively. Cd-MOF 1 shows a 3D diamondoid framework with 1D rhombic and hexagonal channels, and the porosity is 12.9 %. Cd-MOF 2 exhibits a 2D (4,4) layer with a 1D parallelogram channel and porosity of 23.6 %. Cd-MOF 3 has an 8-connected dense network with the Schäfli symbol of [4 24 ⋅6 4 ] based on the Cd 6 cluster. Cd-MOFs 4-5 are isomorphous, and display an absolutely double-bridging 2D (4,4) layer with 1D tetragonal channels and porosities of 29.2 and 28.2 %, which are occupied by DMF and NMP molecules, respectively. Followed by the calcination-thermolysis procedure, Cd-MOFs 1-5 are employed as precursors to prepare MOF-derived porous carbon materials (labeled as PC-me, PC-eth, PC-ipr, PC-dmf and PC-nmp), which have the BET specific surface area of 23, 51, 10, 122, and 96 m 2  g -1 , respectively. The results demonstrate that the specific surface area of PCs is tuned by the porosity of Cd-MOFs, where the later is highly dependent on the solvent. Thereby, the specific surface area of PCs could be adjusted by the solvent used in the synthese of MOF precusors. Significantly, PCs have been further activated by KOH to obtain activated carbon materials (APCs), which possess even higher specific surface area and larger porosity. After a series of characterization and electrochemical investigations, the APC-dmf electrode exhibits the best porous properties and largest specific capacitances (153 F g -1 at 5 mV s -1 and 156 F g -1 at 0.5 Ag -1 ). Meanwhile, the APC-dmf electrode shows excellent cycling stability (ca. 84.2 % after 5000 cycles at 1 Ag -1 ), which can be applied as a suitable electrode material for supercapacitors. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Benefits of adopting good radiation practices in reducing the whole body radiation dose to the nuclear medicine personnel during (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging.

PubMed

Verma, Shashwat; Kheruka, Subhash Chand; Maurya, Anil Kumar; Kumar, Narvesh; Gambhir, Sanjay; Kumari, Sarita

2016-01-01

Positron emission tomography has been established as an important imaging modality in the management of patients, especially in oncology. The higher gamma radiation energy of positron-emitting isotopes poses an additional radiation safety problem. Those working with this modality may likely to receive higher whole body doses than those working only in conventional nuclear medicine. The radiation exposure to the personnel occurs in dispensing the dose, administration of activity, patient positioning, and while removing the intravenous (i.v.) cannula. The estimation of radiation dose to Nuclear Medicine Physician (NMP) involved during administration of activity to the patient and technical staff assisting in these procedures in a positron emission tomography/computed tomography (PET/CT) facility was carried out. An i.v access was secured for the patient by putting the cannula and blood sugar was monitored. The activity was then dispensed and measured in the dose calibrator and administered to the patient by NMP. Personnel doses received by NMP and technical staff were measured using electronic pocket dosimeter. The radiation exposure levels at various working locations were assessed with the help of gamma survey meter. The radiation level at working distance while administering the radioactivity was found to be 106-170 μSv/h with a mean value of 126.5 ± 14.88 μSv/h which was reduced to 4.2-14.2 μSv/h with a mean value of 7.16 ± 2.29 μSv/h with introduction of L-bench for administration of radioactivity. This shows a mean exposure level reduction of 94.45 ± 1.03%. The radiation level at working distance, while removing the i.v. cannula postscanning was found to be 25-70 μSv/h with a mean value of 37.4 ± 13.16 μSv/h which was reduced to 1.0-5.0 μSv/h with a mean value of 2.77 ± 1.3 μSv/h with introduction of L-bench for removal of i.v cannula. This shows a mean exposure level reduction of 92.85 ± 1.78%. This study shows that good radiation practices are very helpful in reducing the personnel radiation doses. Use of radiation protection devices such as L-bench reduces exposure significantly. PET/CT staff members must use their personnel monitors diligently and should do so in a consistent manner so that comparisons of their doses are meaningful from one monitoring period to the next.

Solar and Magnetic Attitude Determination for Small Spacecraft

NASA Technical Reports Server (NTRS)

Woodham, Kurt; Blackman, Kathie; Sanneman, Paul

1997-01-01

During the Phase B development of the NASA New Millennium Program (NMP) Earth Orbiter-1 (EO-1) spacecraft, detailed analyses were performed for on-board attitude determination using the Sun and the Earth's magnetic field. This work utilized the TRMM 'Contingency Mode' as a starting point but concentrated on implementation for a small spacecraft without a high performance mechanical gyro package. The analyses and simulations performed demonstrate a geographic dependence due to diurnal variations in the Earth magnetic field with respect to the Sun synchronous, nearly polar orbit. Sensitivity to uncompensated residual magnetic fields of the spacecraft and field modeling errors is shown to be the most significant obstacle for maximizing performance. Performance has been evaluated with a number of inertial reference units and various mounting orientations for the two-axis Fine Sun Sensors. Attitude determination accuracy using the six state Kalman Filter executing at 2 Hz is approximately 0.2 deg, 3-sigma, per axis. Although EO-1 was subsequently driven to a stellar-based attitude determination system as a result of tighter pointing requirements, solar/magnetic attitude determination is demonstrated to be applicable to a range of small spacecraft with medium precision pointing requirements.

Large Optoelectronic Enhancement of Light-Harvesting Polymers by Chain Confinement and Charge Percolation for LEDs and Photocells Based on Ultrathin Films and CNT Nanocomposites

DTIC Science & Technology

2010-09-30

as determined by TEM. The monomers, reactants, and solvents, 2,2-bis(3amino- 4 - aminophenol )hexafluoropropane (BisAPAF), 4,6-diaminoresorcinal... aminophenol ) hexafluoropropane (BisAPAF) (377.58 mg, 1mmole), into anhydrous NMP ( 4 ml) with anhydrous pyridine (162.89 mg, 2mmole) in a dry 25ml glass...1. REPORT DATE 16 NOV 2010 2. REPORT TYPE FInal 3. DATES COVERED 07-07-2009 to 06-08-2010 4 . TITLE AND SUBTITLE Large Optoelectronic

A ring to rule them all: a cyclic ketene acetal comonomer controls the nitroxide-mediated polymerization of methacrylates and confers tunable degradability.

PubMed

Delplace, Vianney; Guégain, Elise; Harrisson, Simon; Gigmes, Didier; Guillaneuf, Yohann; Nicolas, Julien

2015-08-18

2-Methylene-4-phenyl-1,3-dioxolane (MPDL) was successfully used as a controlling comonomer in NMP with oligo(ethylene glycol) methyl ether methacrylate (MeOEGMA) to prepare well-defined and degradable PEG-based P(MeOEGMA-co-MPDL) copolymers. The level of ester group incorporation is controlled, leading to reductions in molecular weight of up to 95% on hydrolysis. Neither the polymer nor its degradation products displayed cytoxicity. The method was also successfully applied to methyl methacrylate.

Early Detection of Ovarian Cancer by Molecular Targeted Ultrasound Imaging Together with Serum Markers of Tumor-Associated Nuclear Change and Angiogenesis

DTIC Science & Technology

2013-10-01

in a still format as well as in real-time clips (15 minutes for each hen). The effects of targeted microbubbles were visually evaluated online during...Determination of time between the serum prevalence of anti-NMP antibodies as well as increased serum IL-16 levels and the formation of solid tumor...endoplasmic reticular (ER) and mitochondrial stress. Glucose-regulated protein of 78kDa (GRP78) is a marker of ER stress. Tumor-associated ER stress

Sewage pollution in Negril, Jamaica: effects on nutrition and ecology of coral reef macroalgae

NASA Astrophysics Data System (ADS)

Lapointe, B. E.; Thacker, K.; Hanson, C.; Getten, L.

2011-07-01

Coral reefs in the Negril Marine Park (NMP), Jamaica, have been increasingly impacted by nutrient pollution and macroalgal blooms following decades of intensive development as a major tourist destination. A baseline survey of DIN and SRP concentrations, C:N:P and stable nitrogen isotope ratios (δ15N) of abundant reef macroalgae on shallow and deep reefs of the NMP in 1998 showed strong P-limitation and evidence of increasing sewage pollution. In 1999, a sewage collection and treatment project began diverting wastewater from the resort and urban areas to a pond system that discharged partially-treated effluent into the South Negril River (SNR). These sewage discharges significantly increased concentrations of NH{4/+} and SRP (N:P ˜13) in the SNR, which flows into Long Bay and around Negril's "West End". Concentrations of SRP, the primary limiting nutrient, were higher on shallow reefs of the West End in 2001 compared to 1998. Stable nitrogen isotope ratios (δ15N) of abundant reef macroalgae on both shallow and deep reefs of the West End in 2002 were significantly higher than baseline values in 1998, indicating an escalating impact of sewage nitrogen pollution over this timeframe. The increased nutrient concentrations and δ15N enrichment of reef macroalgae correlated with blooms of the chlorophyte Chaetomorpha linum in shallow waters of Long Bay and Codium isthmocladum and Caulerpa cupressoides on deep reefs of the West End. Sewage treatment systems adjacent to coral reefs must include nutrient removal to ensure that DIN and SRP concentrations, after dilution, are below the low thresholds noted for these oligotrophic ecosystems.

Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride.

PubMed

Zheng, Wen-wu; Zhao, Ling; Wei, Yu-meng; Ye, Yun; Xiao, Shun-han

2010-08-01

The objective of this study was to develop and evaluate nanoemulsion system for transdermal delivery of granisetron hydrochloride. Pseudo-ternary phase diagram was constructed to ascertain the concentration range of components of nanoemulsion composed of isopropyl myristate (IPM) as an oil phase, tween 85 as surfactant, ethanol as cosurfactant, water as aqueous phase. The effects of the content of IPM as an oil phase and n-methyl pyrrolidone (NMP) as transdermal enhancer on rat skin permeation of granisetron hydrochloride nanoemulsion were studied in vitro. The results showed that the mean particle size of nanoemulsion ranged from 50.4+/-1.5 to 82.4+/-0.9 nm with homogeneous size distribution. The resulted optimum formulation composed of 2.5% granisetron hydrochloride, 4% IPM, 40% tween 85/ethanol (1 : 1) and 10% NMP showed that the skin permeation rate was the highest (85.39+/-2.90 microg/cm(2)/h) and enhancement of drug permeability was 4.1-fold for transdermal delivery of granisetron hydrochloridein comparison with the control group (20% of tween 85 and 20% of ethanol micelle solution containing 2.5% of granisetron hydrochloride without IPM), and cumulative permeation amount was the highest (891.8+/-2.86 microg/cm(2)) with the shortest lag time (0.11+/-0.02 h) and was stable for at least 12 months. Therefore, the nanoemulsion system developed in this study offers a promising vehicle for the transdermal delivery system of granisetron hydrochloride, which may be as effective as oral or intravenous dosage forms and avoid some difficulties associated with these dosage forms.

Biodegradable injectable in situ implants and microparticles for sustained release of montelukast: in vitro release, pharmacokinetics, and stability.

PubMed

Ahmed, Tarek A; Ibrahim, Hany M; Samy, Ahmed M; Kaseem, Alaa; Nutan, Mohammad T H; Hussain, Muhammad Delwar

2014-06-01

The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin, and ethyl acetate were selected as solvents. The release of 10% (w/v) MK from both systems containing poly-lactic-co-glycolic acid (PLGA) as the biodegradable polymer was compared. Upon contact with the aqueous medium, the PLGA in ISI and ISM systems solidified resulting in implants and microparticles, respectively. The in vitro drug release from the ISI system showed marked difference from miscible solvents (NMP and DMSO) than the partially miscible ones (triacetin and ethyl acetate), and the drug release decreased with increased PLGA concentration. In the ISM system, the initial in vitro drug release decreased with decreased ratio of polymer phase to external oil phase. In vivo studies in rats showed that ISM had slower drug release than the drug release from ISI. Also, the ISM system when compared to ISI system had significantly reduced initial burst effect. In vitro as well as the in vivo studies for both ISI and ISM systems showed sustained release of MK. The ISM system is suitable for sustained release of MK over 4-week period with a lower initial burst compared to the ISI system. Stability studies of the ISI and ISM formulations showed that MK is stable in the formulations stored at 4°C for more than 2 years.

DMAC and NMP as Electrolyte Additives for Li-Ion Cells

NASA Technical Reports Server (NTRS)

Smart, Marshall; Bugga, Ratnakumar; Lucht, Brett

2008-01-01

Dimethyl acetamide (DMAC) and N-methyl pyrrolidinone (NMP) have been found to be useful as high-temperature-resilience-enhancing additives to a baseline electrolyte used in rechargeable lithium-ion electrochemical cells. The baseline electrolyte, which was previously formulated to improve low-temperature performance, comprises LiPF6 dissolved at a concentration of 1.0 M in a mixture comprising equal volume proportions of ethylene carbonate, diethyl carbonate, and dimethyl carbonate. This and other electrolytes comprising lithium salts dissolved in mixtures of esters (including alkyl carbonates) have been studied in continuing research directed toward extending the lower limits of operating temperatures and, more recently, enhancing the high-temperature resilience of such cells. This research at earlier stages, and the underlying physical and chemical principles, were reported in numerous previous NASA Tech Briefs articles. Although these electrolytes provide excellent performance at low temperatures (typically as low as -40 C), when the affected Li-ion cells are subjected to high temperatures during storage and cycling, there occur irreversible losses of capacity accompanied by power fade and deterioration of low-temperature performance. The term "high-temperature resilience" signifies, loosely, the ability of a cell to resist such deterioration, retaining as much as possible of its initial charge/discharge capacity during operation or during storage in the fully charged condition at high temperature. For the purposes of the present development, a temperature is considered to be high if it equals or exceeds the upper limit (typically, 30 C) of the operating-temperature range for which the cells in question are generally designed.

Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells

PubMed Central

Turner, David A.; Hayward, Penelope C.; Baillie-Johnson, Peter; Rué, Pau; Broome, Rebecca; Faunes, Fernando; Martinez Arias, Alfonso

2014-01-01

The development of the central nervous system is known to result from two sequential events. First, an inductive event of the mesoderm on the overlying ectoderm that generates a neural plate that, after rolling into a neural tube, acts as the main source of neural progenitors. Second, the axial regionalization of the neural plate that will result in the specification of neurons with different anteroposterior identities. Although this description of the process applies with ease to amphibians and fish, it is more difficult to confirm in amniote embryos. Here, a specialized population of cells emerges at the end of gastrulation that, under the influence of Wnt and FGF signalling, expands and generates the spinal cord and the paraxial mesoderm. This population is known as the long-term neuromesodermal precursor (NMp). Here, we show that controlled increases of Wnt/β-catenin and FGF signalling during adherent culture differentiation of mouse embryonic stem cells (mESCs) generates a population with many of the properties of the NMp. A single-cell analysis of gene expression within this population reveals signatures that are characteristic of stem cell populations. Furthermore, when this activation is triggered in three-dimensional aggregates of mESCs, the population self-organizes macroscopically and undergoes growth and axial elongation that mimics some of the features of the embryonic spinal cord and paraxial mesoderm. We use both adherent and three-dimensional cultures of mESCs to probe the establishment and maintenance of NMps and their differentiation. PMID:25371361

The formulation makes the honey bee poison.

PubMed

Mullin, Christopher A; Chen, Jing; Fine, Julia D; Frazier, Maryann T; Frazier, James L

2015-05-01

Dr. Fumio Matsumura's legacy embraced a passion for exploring environmental impacts of agrochemicals on non-target species such as bees. Why most formulations are more toxic to bees than respective active ingredients and how pesticides interact to cause pollinator decline cannot be answered without understanding the prevailing environmental chemical background to which bees are exposed. Modern pesticide formulations and seed treatments, particularly when multiple active ingredients are blended, require proprietary adjuvants and inert ingredients to achieve high efficacy for targeted pests. Although we have found over 130 different pesticides and metabolites in beehive samples, no individual pesticide or amount correlates with recent bee declines. Recently we have shown that honey bees are sensitive to organosilicone surfactants, nonylphenol polyethoxylates and the solvent N-methyl-2-pyrrolidone (NMP), widespread co-formulants used in agrochemicals and frequent pollutants within the beehive. Effects include learning impairment for adult bees and chronic toxicity in larval feeding bioassays. Multi-billion pounds of formulation ingredients like NMP are used and released into US environments. These synthetic organic chemicals are generally recognized as safe, have no mandated tolerances, and residues remain largely unmonitored. In contrast to finding about 70% of the pesticide active ingredients searched for in our pesticide analysis of beehive samples, we have found 100% of the other formulation ingredients targeted for analysis. These 'inerts' overwhelm the chemical burden from active pesticide, drug and personal care ingredients with which they are formulated. Honey bees serve as an optimal terrestrial bioindicator to determine if 'the formulation and not just the dose makes the poison'. Copyright © 2014 Elsevier Inc. All rights reserved.

UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases.

PubMed

Kerai, Laxmi Valji; Hilton, Stephen; Murdan, Sudaxshina

2015-08-15

Nail diseases are common, cause significant distress and treatments are far from successful. Our aim was to investigate the potential of UV-curable gels - currently used as cosmetics - as topical drug carriers for their treatment. These formulations have a long residence on the nail, which is expected to increase patient compliance and the success of topical therapy. The gels are composed of the diurethane dimethacrylate, ethyl methacrylate, 2-hydroxy-2-methylpropiophenone, an antifungal drug (amorolfine HCl or terbinafine HCl) and an organic liquid (ethanol or NMP) as drug solvent. Following its application to a substrate and exposure to a UVA lamp for 2 min, the gel polymerises and forms a smooth, glossy and amorphous film, with negligible levels of residual monomers. No drug-polymer interactions were found and drug loading did not affect the film's properties, such as thickness, crystallinity and transition temperatures. In contrast, the organic solvent did influence the film's properties; NMP-containing films had lower glass transition temperatures, adhesion and water resistance than ethanol-based ones. Water-resistance being a desired property, ethanol-based formulations were investigated further for stability, drug release and ungual permeation. The films were stable under accelerated stability testing conditions. Compared to terbinafine, amorolfine was released to a greater extent, had a higher ungual flux, but a lower concentration in the nailplate. However, both drugs were present at considerably high levels in the nail when their MICs are taken into account. We thus conclude that UV-curable gels are promising candidates as topical nail medicines. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

In situ forming phase-inversion implants for sustained ocular delivery of triamcinolone acetonide.

PubMed

Sheshala, Ravi; Hong, Gan Chew; Yee, Wong Pui; Meka, Venkata Srikanth; Thakur, Raghu Raj Singh

2018-02-26

The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA (at 0.5%, 1% and 2.5% w/w loading) was dissolved in N-methyl-2-pyrrolidone (NMP) solvent and then incorporated 30% w/w PLGA (50/50 and 75/25) polymer to prepare homogenous injectable solution. The formulations were evaluated for rheological behaviour using rheometer, syringeability by texture analyser, water uptake and rate of implant formation by optical coherence tomography (OCT) microscope. Phase inversion in situ forming formulations were injected into PBS pH 7.3 to form an implant and release samples were collected and analysed for drug content using a HPLC method. All formulations exhibited good syringeability and rheological properties (viscosity: 0.19-3.06 Pa.s) by showing shear thinning behaviour which enable them to remain as free-flowing solution for ease administration. The results from OCT microscope demonstrated that thickness of the implants were increased with the increase in time and the rate of implant formation indicated the fast phase inversion. The drug release from implants was sustained over a period of 42 days. The research findings demonstrated that PLGA/NMP-based phase inversion in situ forming implants can improve compliance in patient's suffering from ocular diseases by sustaining the drug release for a prolonged period of time and thereby reducing the frequency of ocular injections.

Structural elucidation, molecular representation and solvent interactions of vitrinite-rich and inertinite-rich South African coals

NASA Astrophysics Data System (ADS)

van Niekerk, Daniel

The structural differences and similarities of two Permian-aged South African coals, vitrinite-rich Waterberg and inertinite-rich Highveld coals (similar rank, carbon content and Permian age), were evaluated. With South African coals the opportunity presented itself to study not only Permian-aged Gondwana vitrinite but also inertinite. It was expected that these coals would differ from Northern hemisphere Carboniferous coals. It was concluded from various structural data that both coals, although different in maceral composition and depositional basins, are similar in their base structural composition. The main differences were that the inertinite-rich Highveld coal was more ordered, more aromatic, and had less hydrogen than the vitrinite-rich Waterberg coal. Analytical data were used to construct large-scale advanced molecular representations for vitrinite-rich Waterberg and inertinite-rich Highveld coals. The three-dimensional models were structurally diverse with a molecular weight range of 78 to 1900 amu. The vitrinite-rich coal model consisted of 18,572 atoms and 191 individual molecules and the inertinite-rich coal model consisted of 14,242 atoms and 158 individual molecules. This largescale modeling effort was enabled by the development of various PERL scripts to automate various visualization and analytical aspects. Coal swelling studies were conducted using the traditional pack-bed swelling method and a new novel single-particle stop-motion videography swelling method with NMP and CS2/NMP solvents. The pack-bed swelling showed that vitrinite-rich coal had a greater swelling extent and that swelling extent for both coals was greater in CS2/NMP binary solvent than for NMP. Single-particle swelling experiments showed that both coals, for both solvents, exhibit overshoot-type and climbing-type swelling behaviors. Inertinite-coal had a faster swelling rate, in both solvents, than the vitrinite-rich coal. The single-particle swelling data was used to calculate the kinetic parameters and it was found that the swelling was governed by relaxation of the coal structure (super-Case II swelling). X-ray computed tomography was conducted confirming anisotropic swelling. The petrographic transitions (maceral-group composition and reflectance) with solvent swelling and extraction were quantified. No changes in the maceral compositions were found, but changes in some coal particles were observed. Random reflectance analysis showed that, for both vitrinite and inertinite, there is a decrease in reflectance values with solvent treatment. Vitrinite reflectograms showed a shift from the dominant reflecting V-types to lower V-types. The inertinite reflectograms exhibited an increase in number of I-types (broadening of reflectrograms). Molecular simulation and visualization approaches to solvent swelling and extraction were performed on the proposed molecular models of vitrinite-rich and inertinite-rich coals. A theoretical extraction yield was determined using solubility parameters and showed agreement with experimental extraction yield trends. Statistical Associating Fluid Theory (SAFT) modeling was explored to test whether this method could predict swelling extent. The predicted swelling trends of SAFT were comparable to that of the experimental swelling results. SAFT was found to be a promising tool for solvent-coal interaction predictions. Partially solvent swollen structures were constructed by the addition of solvent molecules to the original coal molecules using a amorphous building approach. This method showed that coal-coal non-bonding interaction changed with the introduction of solvent. A disruption in the van der Waals interaction energies and a change in hydrogen bond distributions were observed in the swollen coal models and quantified. It was concluded that small changes in coal structure translates to significant changes in solvent interaction behavior. These changes were successfully visualized and simulated using atomistic molecular representations.

Effects of gas composition in headspace and bicarbonate concentrations in media on gas and methane production, degradability, and rumen fermentation using in vitro gas production techniques.

PubMed

Patra, Amlan Kumar; Yu, Zhongtang

2013-07-01

Headspace gas composition and bicarbonate concentrations in media can affect methane production and other characteristics of rumen fermentation in in vitro gas production systems, but these 2 important factors have not been evaluated systematically. In this study, these 2 factors were investigated with respect to gas and methane production, in vitro digestibility of feed substrate, and volatile fatty acid (VFA) profile using in vitro gas production techniques. Three headspace gas compositions (N2+ CO2+ H2 in the ratio of 90:5:5, CO2, and N2) with 2 substrate types (alfalfa hay only, and alfalfa hay and a concentrate mixture in a 50:50 ratio) in a 3×2 factorial design (experiment 1) and 3 headspace compositions (N2, N2 + CO2 in a 50:50 ratio, and CO2) with 3 bicarbonate concentrations (80, 100, and 120 mM) in a 3×3 factorial design (experiment 2) were evaluated. In experiment 1, total gas production (TGP) and net gas production (NGP) was the lowest for CO2, followed by N2, and then the gas mixture. Methane concentration in headspace gas after fermentation was greater for CO2 than for N2 and the gas mixture, whereas total methane production (TMP) and net methane production (NMP) were the greatest for CO2, followed by the gas mixture, and then N2. Headspace composition did not affect in vitro digestibility or the VFA profile, except molar percentages of propionate, which were greater for CO2 and N2 than for the gas mixture. Methane concentration in headspace gas, TGP, and NGP were affected by the interaction of headspace gas composition and substrate type. In experiment 2, increasing concentrations of CO2 in the headspace decreased TGP and NGP quadratically, but increased the concentrations of methane, NMP, and in vitro fiber digestibility linearly, and TMP quadratically. Fiber digestibility, TGP, and NGP increased linearly with increasing bicarbonate concentrations in the medium. Concentrations of methane and NMP were unaffected by bicarbonate concentration, but TMP tended to increase due to increasing bicarbonate concentration. Although total VFA concentration and molar percentage of butyrate were unchanged, the molar percentage of acetate, and acetate-to-propionate ratio decreased, whereas the molar percentage of propionate increased quadratically with increasing bicarbonate concentration. This study demonstrated for the first time that headspace composition, especially CO2 content, and bicarbonate concentration in media could significantly influence gas and methane production, and rumen fermentation in gas production techniques. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

[Clinical effect of ultrasound-guided injection of biodegradable poly(lactic-co-glycolic acid)-Fe3O4 in situ implant for magnetic thermal ablation in treatment of nude mice with human liver cancer SMMC-7721 cells].

PubMed

Liang, B; Zuo, G Q; Zheng, Y Y; He, S; Zuo, D Y

2016-12-20

Objective: To prepare the Fe 3 O 4 -loaded biodegradable liquid-solid phase inversion poly(lactic-co-glycolic acid) (PLGA) in situ implant for ultrasound-guided injection into nude mouse tumor model, and to investigate its clinical effect in thermomagnetic treatment of nude mice with human liver cancer SMMC-7721 cells in an alternating magnetic field. Methods: An in situ implant containing 10% Fe 3 O 4 was prepared, and 50 μl Fe 3 O 4 -PLGA-NMP gel was injected into the subcutaneous tissue of Kunming mice. The degradation of this material was observed for 2 consecutive months, and the changes in body weight were recorded. HE staining and Prussian blue staining were performed for the heart, liver, spleen, lung, and kidney of Kunming mice. Fresh ex vivo bovine liver was taken and cut into cubes with a dimension of 2 cm×2 cm×2 cm and then 50 μl Fe 3 O 4 -PLGA-NMP gel was injected; after phase inversion, the cubes of ex vivo bovine liver were heated for 1, 2, 3, 4, and 5 minutes, respectively, and then cut open for observing the range of ablation; HE staining was also performed. Micro-CT scan was performed after ultrasound-guided injection of 50 μl Fe 3 O 4 -PLGA gel into the tumors of the nude mice, and then the nude mice were divided into treatment group and control group. The mice in the treatment group were given thermomagnetic treatment for 3 minutes, and tumor growth was observed daily. Results: The biodegradation of Fe 3 O 4 -PLGA-NMP implant showed that the subcutaneously injected material was gradually metabolized at 2 weeks after injection and that the nude mice were in good condition. The bovine liver ablation experiment showed that the range of ablation of 50 μl Fe 3 O 4 -PLGA implant reached 1.46 ± 0.11 cm. HE staining showed that part of bovine liver had coagulative necrosis. The phase inversion experiment of Fe 3 O 4 -PLGA gel showed quick liquid-solid phase inversion of the material after injection into the tumor, and the process of liquid-solid phase inversion could be monitored by ultrasound and CT. The detachment and incrustation of the tumor started at 2 days after treatment, the wound started to heal 15 days later, and the tumor tissue disappeared completely. Conclusion: Ultrasound-guided injection of biodegradable Fe 3 O 4 -PLGA in situ implant combined with magnetic thermal ablation can effectively treat human liver cancer SMMC-7721 cells in nude mice.

The Response of wnt/ ß-Catenin Signaling Pathway in Osteocytes Under Simulated Microgravity

NASA Astrophysics Data System (ADS)

Yang, Xiao; Sun, Lian-Wen; Liang, Meng; Wang, Xiao-Nan; Fan, Yu-Bo

2015-11-01

Osteocytes were considered as potential sensors of mechanical loading and orchestrate the bone remodeling adapted to mechanical loading. On the other hand, osteocytes are also considered as the unloading sensors in vivo. Previous studies showed that the mechanosensation and mechanotransduction of osteocytes may play an essential role in mediating bone response to microgravity, and one of the most important molecular signaling pathway involved in the mechanotransduction is the Wnt/ ß-catenin signaling pathway. In order to investigate the effect of simulated microgravity on the Wnt/ ß-catenin signaling pathway in osteocytes, MLO-Y4 cells (an osteocyte-like cell line) were cultured under controlled rotation to simulate microgravity for 5 days. The cytoskeleton and ß-catenin nuclear translocation of MLO-Y4 cells were detected by laser scanning confocal microscope and the fluorescence intensity was quantified; the mRNA expressions of upstream and downstream key components in Wnt canonical signaling were detected with RT-PCR. Two regulators of the Wnt/ ß-catenin pathway, NMP4/CIZ and Smads, were also investigated by RT-PCR; finally the expression of Wnt target genes and Sost protein level were detected with the absence or presence of the Sclerostin antibody (Scl-AbI) under simulated microgravity. The results showed that under simulated microgravity, (1) F-actin filaments were disassembled and some short dendritic processes appeared at the cell periphery; (2) the gene expression of Wnt3a, Wnt5a, DKK1, CyclinD1, LEF-1 and CX43 in the simulated microgravity group were significantly lower whereas Wnt1 and Sost in the simulated microgravity group were significantly higher than the control group; (3) the gene and protein level of ß-catenin were reduced, and no ß-catenin nuclear translocation observed; (4) the gene expression of Smad1, Smad4 and Smad7 were significantly lower whereas NMP4/CIZ and Smad3 in the simulated microgravity were significantly higher than the control group; (5) Scl-AbI partially inhibited the down-regulation of simulated microgravity to Wnt target gene expression and Sclerostin protein expression. The results suggested that firstly the cytoskeleton was disturbed in MLO-Y4 by simulated microgravity; secondly the activity of Wnt/ ß-catenin signaling pathway was depressed, with the nuclear translocation of ß-catenin suppressed by simulated microgravity; thirdly the Wnt/ ß-catenin signaling pathway positive regulators (Smads) were decreased, while the negative regulator (NMP4/CIZ) was increased under simulated microgravity; finally Scl-AbI could partially restore the adverse effect of simulated microgravity to Wnt signaling. This study may help us to understand the mechanotransduction alteration of Wnt/ ß-catenin signaling pathway in osteocytes under simulated microgravity, and further may partly clarify the mechanism of microgravity-induced osteoporosis.

KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Effects of lower limb prosthesis on activity, participation, and quality of life: a systematic review.

PubMed

Samuelsson, Kersti A M; Töytäri, Outi; Salminen, Anna-Liisa; Brandt, Ase

2012-06-01

Effects presented on the use of assistive devices such as prosthesis are often based on laboratory findings (i.e. efficacy). To summarise and evaluate findings from studies on effectiveness of lower limb prostheses for adults in real life contexts, primarily in terms of activity, participation, and quality of life (QoL) and secondarily in terms of user satisfaction, use/non-use, and/or cost-effectiveness. Systematic review. We included controlled studies and non-controlled follow-up studies including both baseline and follow-up data. Using 14 different databases supplemented with manual searches, we searched for studies published from 1998 until June 2009. Out of an initial 818 identified publications, eight met the inclusion criteria. Four studies reported on the effectiveness of a microprocessor-controlled knee (MP-knee) compared to a non-microprocessor-controlled knee (NMP-knee). Results were inconsistent except for quality of life and use/non-use, where the authors reported an improvement with the MP-knee compared to the NMP-knee. The remaining four studies included a diversity of prosthetic intervention measures and types of endpoints. Overall, there was an inconsistency in results and study quality. This review highlights the need for high-quality research studies that reflect the effectiveness of different prosthesis interventions in terms of users' daily living and QoL. Clinical guidelines are important to every practitioner. Information on expected effectiveness from assistive devices should be well founded and contain both facts about the device quality and its contribution to users' daily lives. Thus, studies based on users' experiences from prosthetic use in everyday life activities are of great importance.

Emulsion-Based Intradermal Delivery of Melittin in Rats.

PubMed

Han, Sang Mi; Kim, Se Gun; Pak, Sok Cheon

2017-05-19

Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin through dermatomed rat skin. A formulated emulsion containing 1% ( w / v ) BV was prepared. The emulsion was compared with distilled water (DW) and 25% ( w / v ) N -methyl-2-pyrrolidone (NMP) in DW. Permeation of melittin from aqueous solution through the dermatomed murine skin was evaluated using the Franz diffusion cells. Samples of receptor cells withdrawn at pre-determined time intervals were measured for melittin amount. After the permeation study, the same skin was used for melittin extraction. In addition, a known amount of melittin (5 μg/mL) was added to stratum corneum, epidermis, and dermis of the rat skin, and the amount of melittin was measured at pre-determined time points. The measurement of melittin from all samples was done with HPLC-MS/MS. No melittin was detected in the receptor phase at all time points in emulsion, DW, or NMP groups. When the amount of melittin was further analyzed in stratum corneum, epidermis, and dermis from the permeation study, melittin was still not detected. In an additional experiment, the amount of melittin added to all skin matrices was corrected against the amount of melittin recovered. While the total amount of melittin was retained in the stratum corneum, less than 10% of melittin remained in epidermis and dermis within 15 and 30 min, respectively. Skin microporation with BV emulsion facilitates the penetration of melittin across the stratum corneum into epidermis and dermis, where emulsified melittin could have been metabolized by locally-occurring enzymes.

Use of ionic liquids as headspace gas chromatography diluents for the analysis of residual solvents in pharmaceuticals.

PubMed

Nacham, Omprakash; Ho, Tien D; Anderson, Jared L; Webster, Gregory K

2017-10-25

In this study, two ionic liquids (ILs), 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([BMIM][NTf 2 ]) and trihexyltetradecylphosphonium bis[(trifluoromethyl)sulfonyl]imide ([P 66614 ][NTf 2 ]) were examined as contemporary diluents for residual solvent analysis using static headspace gas chromatography (SHS-GC) coupled with flame ionization detection (FID). ILs are a class of non-molecular solvents featuring negligible vapor pressure and high thermal stabilities. Owing to these favorable properties, ILs have potential to enable superior sensitivity and reduced interference, compared to conventional organic diluents, at high headspace incubation temperatures. By employing the [BMIM][NTf 2 ] IL as a diluent, a 25-fold improvement in limit of detection (LOD) was observed with respect to traditional HS-GC diluents, such as N-methylpyrrolidone (NMP). The established IL-based method demonstrated LODs ranging from 5.8 parts-per-million (ppm) to 20ppm of residual solvents in drug substances. The optimization of headspace extraction conditions was performed prior to method validation. An incubation temperature of 140°C and a 15min incubation time provided the best sensitivity for the analysis. Under optimized experimental conditions, the mass of residual solvents partitioned in the headspace was higher when using [BMIM][NTf 2 ] than NMP as a diluent. The analytical performance was demonstrated by determining the repeatability, accuracy, and linearity of the method. Linear ranges of up to two orders of magnitude were obtained for class 3 solvents. Excellent analyte recoveries were obtained in the presence of three different active pharmaceutical ingredients. Owing to its robustness, high throughput, and superior sensitivity, the HS-GC IL-based method can be used as an alternative to existing residual solvent methods. Copyright © 2017 Elsevier B.V. All rights reserved.

Surface Fluorination of Reactive Battery Anode Materials for Enhanced Stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Jie; Liao, Lei; Shi, Feifei

Significant increases in the energy density of batteries must be achieved by exploring new materials and cell configurations. Lithium metal and lithiated silicon are two promising high-capacity anode materials. Unfortunately, both of these anodes require a reliable passivating layer to survive the serious environmental corrosion during handling and cycling. Here we developed a surface fluorination process to form a homogeneous and dense LiF coating on reactive anode materials, with in situ generated fluorine gas, by using a fluoropolymer, CYTOP, as the precursor. The process is effectively a “reaction in the beaker”, avoiding direct handling of highly toxic fluorine gas. Formore » lithium metal, this LiF coating serves as a chemically stable and mechanically strong interphase, which minimizes the corrosion reaction with carbonate electrolytes and suppresses dendrite formation, enabling dendrite-free and stable cycling over 300 cycles with current densities up to 5 mA/cm 2. Lithiated silicon can serve as either a pre-lithiation additive for existing lithium-ion batteries or a replacement for lithium metal in Li–O 2 and Li–S batteries. However, lithiated silicon reacts vigorously with the standard slurry solvent N-methyl-2-pyrrolidinone (NMP), indicating it is not compatible with the real battery fabrication process. With the protection of crystalline and dense LiF coating, Li xSi can be processed in anhydrous NMP with a high capacity of 2504 mAh/g. With low solubility of LiF in water, this protection layer also allows Li xSi to be stable in humid air (~40% relative humidity). Furthermore, this facile surface fluorination process brings huge benefit to both the existing lithium-ion batteries and next-generation lithium metal batteries.« less

Surface Fluorination of Reactive Battery Anode Materials for Enhanced Stability

DOE PAGES

Zhao, Jie; Liao, Lei; Shi, Feifei; ...

2017-07-26

Significant increases in the energy density of batteries must be achieved by exploring new materials and cell configurations. Lithium metal and lithiated silicon are two promising high-capacity anode materials. Unfortunately, both of these anodes require a reliable passivating layer to survive the serious environmental corrosion during handling and cycling. Here we developed a surface fluorination process to form a homogeneous and dense LiF coating on reactive anode materials, with in situ generated fluorine gas, by using a fluoropolymer, CYTOP, as the precursor. The process is effectively a “reaction in the beaker”, avoiding direct handling of highly toxic fluorine gas. Formore » lithium metal, this LiF coating serves as a chemically stable and mechanically strong interphase, which minimizes the corrosion reaction with carbonate electrolytes and suppresses dendrite formation, enabling dendrite-free and stable cycling over 300 cycles with current densities up to 5 mA/cm 2. Lithiated silicon can serve as either a pre-lithiation additive for existing lithium-ion batteries or a replacement for lithium metal in Li–O 2 and Li–S batteries. However, lithiated silicon reacts vigorously with the standard slurry solvent N-methyl-2-pyrrolidinone (NMP), indicating it is not compatible with the real battery fabrication process. With the protection of crystalline and dense LiF coating, Li xSi can be processed in anhydrous NMP with a high capacity of 2504 mAh/g. With low solubility of LiF in water, this protection layer also allows Li xSi to be stable in humid air (~40% relative humidity). Furthermore, this facile surface fluorination process brings huge benefit to both the existing lithium-ion batteries and next-generation lithium metal batteries.« less

Transient state kinetics of transcription elongation by T7 RNA polymerase.

PubMed

Anand, Vasanti Subramanian; Patel, Smita S

2006-11-24

The single subunit DNA-dependent RNA polymerase (RNAP) from bacteriophage T7 catalyzes both promoter-dependent transcription initiation and promoter-independent elongation. Using a promoter-free substrate, we have dissected the kinetic pathway of single nucleotide incorporation during elongation. We show that T7 RNAP undergoes a slow conformational change (0.01-0.03 s(-1)) to form an elongation competent complex with the promoter-free substrate (dissociation constant (Kd) of 96 nM). The complex binds to a correct NTP (Kd of 80 microM) and incorporates the nucleoside monophosphate (NMP) into RNA primer very efficiently (220 s(-1) at 25 degrees C). An overall free energy change (-5.5 kcal/mol) and internal free energy change (-3.7 kcal/mol) of single NMP incorporation was calculated from the measured equilibrium constants. In the presence of inorganic pyrophosphate (PPi), the elongation complex catalyzes the reverse pyrophosphorolysis reaction at a maximum rate of 0.8 s(-1) with PPi Kd of 1.2 mM. Several experiments were designed to investigate the rate-limiting step in the pathway of single nucleotide addition. Acid-quench and pulse-chase kinetics indicated that an isomerization step before chemistry is rate-limiting. The very similar rate constants of sequential incorporation of two nucleotides indicated that the steps after chemistry are fast. Based on available data, we propose that the preinsertion to insertion isomerization of NTP observed in the crystallographic studies of T7 RNAP is a likely candidate for the rate-limiting step. The studies here provide a kinetic framework to investigate structure-function and fidelity of RNA synthesis and to further explore the role of the conformational change in nucleotide selection during RNA synthesis.

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Flexible free-standing TiO2/graphene/PVdF films as anode materials for lithium-ion batteries

NASA Astrophysics Data System (ADS)

Ren, H. M.; Ding, Y. H.; Chang, F. H.; He, X.; Feng, J. Q.; Wang, C. F.; Jiang, Y.; Zhang, P.

2012-12-01

Graphene composites were prepared by hydrothermal method using titanium dioxide (TiO2) adsorbed graphene oxide (GO) sheets as precursors. Free-standing hybrid films for lithium-ion batteries were prepared by adding TiO2/graphene composites to the polyvinylidene fluoride (PVdF)/N-methyl-2-pyrrolidone (NMP) solution, followed by a solvent evaporation technique. These films were characterized by atomic force microscopy (AFM), X-ray diffraction (XRD), scanning electron microscopy (SEM) and various electrochemical techniques. Flexible films show an excellent cycling performance, which was attributed to the interconnected graphene conducting network, which depressed the increasing of electric resistance during the cycling.

Spatial Electron-hole Separation in a One Dimensional Hybrid Organic-Inorganic Lead Iodide

NASA Astrophysics Data System (ADS)

Savory, Christopher N.; Palgrave, Robert G.; Bronstein, Hugo; Scanlon, David O.

2016-02-01

The increasing efficiency of the inorganic-organic hybrid halides has revolutionised photovoltaic research. Despite this rapid progress, the significant issues of poor stability and toxicity have yet to be suitably overcome. In this article, we use Density Functional Theory to examine (Pb2I6) · (H2DPNDI) · (H2O) · (NMP), an alternative lead-based hybrid inorganic-organic solar absorber based on a photoactive organic cation. Our results demonstrate that optical properties suitable for photovoltaic applications, in addition to spatial electron-hole separation, are possible but efficient charge transport may be a limiting factor.

Edge-Functionalization of Pyrene as a Miniature Graphene via Friedel–Crafts Acylation Reaction in Poly(Phosphoric Acid)

PubMed Central

2010-01-01

The feasibility of edge-functionalization of graphite was tested via the model reaction between pyrene and 4-(2,4,6-trimethylphenyloxy)benzamide (TMPBA) in poly(phosphoric acid) (PPA)/phosphorous pentoxide (P2O5) medium. The functionalization was confirmed by various characterization techniques. On the basis of the model study, the reaction condition could be extended to the edge-functionalization of graphite with TMPBA. Preliminary results showed that the resultant TMPBA-grafted graphite (graphite-g-TMPBA) was found to be readily dispersible in N-methyl-2-pyrrolidone (NMP) and can be used as a precursor for edge-functionalized graphene (EFG). PMID:21076664

Identification of α-Chloro-2,2',4,4',6,6'-Hexanitrobibenzyl as an Impurity in Hexanitrostilbene

NASA Astrophysics Data System (ADS)

Bellamy, A. J.

2010-01-01

The final intermediate in the Shipp synthesis of 2,2‧,4,4‧,6,6‧-hexanitrostilbene (HNS) from TNT, α-chloro-2,2‧,4,4‧,6,6‧-hexanitrobibenzyl, has been extracted and characterized by nuclear magnetic resonance (NMR) spectroscopy, chlorine elemental analysis, and high-performance liquid chromatography (HPLC). It has also been shown that digestion in NMP of HNS containing α-chlorohexanitrobibenzyl generates another chlorine-containing by-product, 2-chloro-2‧,4,4‧,6,6‧-pentanitrostilbene. This too has been characterized by NMR spectroscopy, chlorine elemental analysis, and HPLC.

Using Single Drop Microextraction for Headspace Analysis with Gas Chromatography

NASA Astrophysics Data System (ADS)

Riccio, Daniel; Wood, Derrick C.; Miller, James M.

2008-07-01

Headspace (HS) gas chromatography (GC) is commonly used to analyze samples that contain non-volatiles. In 1996, a new sampling technique called single drop microextraction, SDME, was introduced, and in 2001 it was applied to HS analysis. It is a simple technique that uses equipment normally found in the undergraduate laboratory, making it ideal for instructional use, especially to illustrate HS analysis or as an alternative to solid-phase microextraction (SPME) to which it is very similar. The basic principles and practice of HS-GC using SDME are described, including a complete review of the literature. Some possible experiments are suggested using water and N -methylpyrrolidone (NMP) as solvents.

Spatial Electron-hole Separation in a One Dimensional Hybrid Organic–Inorganic Lead Iodide

PubMed Central

Savory, Christopher N.; Palgrave, Robert G.; Bronstein, Hugo; Scanlon, David O.

2016-01-01

The increasing efficiency of the inorganic-organic hybrid halides has revolutionised photovoltaic research. Despite this rapid progress, the significant issues of poor stability and toxicity have yet to be suitably overcome. In this article, we use Density Functional Theory to examine (Pb2I6) · (H2DPNDI) · (H2O) · (NMP), an alternative lead-based hybrid inorganic-organic solar absorber based on a photoactive organic cation. Our results demonstrate that optical properties suitable for photovoltaic applications, in addition to spatial electron-hole separation, are possible but efficient charge transport may be a limiting factor. PMID:26858147

Presidential Leadership in the Development of the U.S. Space Program

NASA Technical Reports Server (NTRS)

Launius, Roger D. (Editor); Mccurdy, Howard E. (Editor)

1994-01-01

Papers presented at a historical symposium on Presidential leadership in the space program include the following: 'The Imperial Presidency in the History of Space Exploration'; 'The Reluctant Racer: Dwight D. Eisenhower and United States Space Policy'; 'Kennedy and the Decision to Go to the Moon'; 'Johnson, Project Apollo, and the Politics of Space Program Planning'; 'The Presidency, Congress, and the Deceleration of the U.S. Space Program in the 1970s'; 'Politics not Science: The U.S. Space Program in the Reagan and Bush Years'; 'Presidential Leadership and International Aspects of the Space Program'; 'National Leadership and Presidential Power'; and 'Epilogue: Beyond NASA Exceptionalism'.

Logistics: An integral part of cost efficient space operations

NASA Technical Reports Server (NTRS)

Montgomery, Ann D.

1996-01-01

The logistics of space programs and its history within NASA are discussed, with emphasis on manned space flight and the Space Shuttle program. The lessons learned and the experience gained during these programs are reported on. Key elements of logistics are highlighted, and the problems and issues that can be expected to arise in relation to the support of long-term space operations and future space programs, are discussed. Such missions include the International Space Station program and the reusable launch vehicle. Possible solutions to the problems identified are outlined.

The International Space Station in Space Exploration

NASA Technical Reports Server (NTRS)

Gerstenmaier, William H.; McKay, Meredith M.

2006-01-01

The International Space Station (ISS) Program has many lessons to offer for the future of space exploration. Among these lessons of the ISS Program, three stand out as instrumental for the next generation of explorers. These include: 1) resourcefulness and the value of a strong international partnership; 2) flexibility as illustrated by the evolution of the ISS Program and 3) designing with dissimilar redundancy and simplicity of sparing. These lessons graphically demonstrate that the ISS Program can serve as a test bed for future programs. As the ISS Program builds upon the strong foundation of previous space programs, it can provide insight into the prospects for continued growth and cooperation in space exploration. As the capacity for spacefaring increases worldwide and as more nations invest in space exploration and space sector development, the potential for advancement in space exploration is unlimited. By building on its engineering and research achievements and international cooperation, the ISS Program is inspiring tomorrow s explorers today.

The organizations for space education and outreach programs in the Republic of Korea

NASA Astrophysics Data System (ADS)

Lee, Jeongwon; Jo, Hyun-Jung; Choi, Jae Dong

2011-09-01

Korea has a short history in space development compared to neighboring countries like Japan, China, India and Russia. During the past 20 years, Korea has focused on developing satellite and rocket space technology under the national space development plan. KOMPSAT-1 and 2, and KSLV-1 are the results of the selection and concentration policy of the Korean government. Due to the arduous mission of developing hardware oriented space technology, the topic of space education and outreach for the general public has not received much in the national space program. But recently, the Korean government has begun planning a space science outreach program in the detailed action plan of the mid-long term national space development plan. This paper introduces and analyzes the organizations performing space education and outreach programs for primary and secondary schools in the Republic of Korea. "Young Astronaut Korea (YAK)" is one such program. This is a non-profit organization established to provide space education for students in 1989 when Korea just started its space development program. "YAK" is a unique group in Korea for space education and outreach activities because it is organized by branches at each school in the nation and it is much like the Boy Scout and Girl Scout programs. Space Science Museum and National Youth Space Center (NYSC), which are located near NARO space center in the southernmost part of the Korean peninsula are other examples of space education and outreach programs. NARO space center, which is the only launch site in Korea became the center of public interest by showing the KSLV-1 launch in 2009 and will be expected to play a key role for the space education of students in the Republic of Korea. The NYSC will perform many mission oriented space education programs for students as Space Camp in the USA does. This paper introduces the status of the space education and outreach programs of each organization and presents the future direction of space education and outreach for the Korean public and students. If these three organizations cooperate with each other and develop systematic programs of space education and outreach for the people, they will prepare a base for growth and progress in future space science and technology in Korea.

International Space Programs. Aerospace Education III.

ERIC Educational Resources Information Center

Bulmer, S. B.

This book, one in the series on Aerospace Education III, is a collection of the diverse information available regarding the international space programs. The five goals listed for the book are: to examine the Soviet space program, to understand the future of Soviet space activity, to examine other national and international space programs, to…

Systems autonomy technology: Executive summary and program plan

NASA Technical Reports Server (NTRS)

Bull, John S (Editor)

1987-01-01

The National Space Strategy approved by the President and Congress in 1984 sets for NASA a major goal of conducting effective and productive space applications and technology programs which contribute materially toward United States leadership and security. To contribute to this goal, OAST supports the Nation's civil and defense space programs and overall economic growth. OAST objectives are to ensure timely provision of new concepts and advanced technologies, to support both the development of NASA missions in space and the space activities of industry and other organizations, to utilize the strengths of universities in conducting the NASA space research and technology program, and to maintain the NASA centers in positions of strength in critical space technology areas. In line with these objectives, NASA has established a new program in space automation and robotics that will result in the development and transfer and automation technology to increase the capabilities, productivity, and safety of NASA space programs including the Space Station, automated space platforms, lunar bases, Mars missions, and other deep space ventures. The NASA/OAST Automation and Robotics program is divided into two parts. Ames Research Center has the lead role in developing and demonstrating System Autonomy capabilities for space systems that need to make their own decisions and do their own planning. The Jet Propulsion Laboratory has the lead role for Telerobotics (that portion of the program that has a strong human operator component in the control loop and some remote handling requirement in space). This program is intended to be a working document for NASA Headquarters, Program Offices, and implementing Project Management.

Orbital Space Plane (OSP) Program

NASA Technical Reports Server (NTRS)

McKenzie, Patrick M.

2003-01-01

Lockheed Martin has been an active participant in NASA's Space Launch Initiative (SLI) programs over the past several years. SLI, part of NASA's Integrated Space Transportation Plan (ISTP), was restructured in November of 2002 to focus the overall theme of safer, more afford-able space transportation along two paths - the Orbital Space Plane Program and the Next Generation Launch Technology programs. The Orbital Space Plane Program has the goal of providing rescue capability from the International Space Station by 2008 and transfer capability for crew (and limited cargo) by 2012. The Next Generation Launch Technology program is combining research and development efforts from the 2nd Generation Reusable Launch Vehicle (2GRLV) program with cutting-edge, advanced space transportation programs (previously designated 3rd Generation) into one program aimed at enabling safe, reliable, cost-effective reusable launch systems by the middle of the next decade. Lockheed Martin is one of three prime contractors working to bring Orbital Space Plane system concepts to a system definition level of maturity by December of 2003. This paper and presentation will update the international community on the progress of the' OSP program, from an industry perspective, and provide insights into Lockheed Martin's role in enabling the vision of a safer, more affordable means of taking people to and from space.

KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, United Space Alliance (USA) Director of Orbiter Operations Patty Stratton, and NASA Space Shuttle Program Manager William Parsons view the underside of Shuttle Discovery in Orbiter Processing Facility Bay 3. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, United Space Alliance (USA) Director of Orbiter Operations Patty Stratton, and NASA Space Shuttle Program Manager William Parsons view the underside of Shuttle Discovery in Orbiter Processing Facility Bay 3. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

The 1985 long-range program plan

NASA Technical Reports Server (NTRS)

1984-01-01

That continual evolution of NASA's research and development, is reflected in the missions, goals, and objectives planned for FY1985 and later years, in accordance with the responsibilities by the National Aeronautics and Space Act of 1958, as amended. New starts for the next ten years and space program activities to year 2000 are highlighted including space science and applications, space flight, space station, space tracking and data systems, and space research and technology. Space programs for the early 21st century and aeronautics programs up to and beyond the year 2000 are also covered.

Participating in commercial space ventures: Introduction to NASA Centers for the Commercial Development of Space and the Cooperative Agreements Programs

NASA Technical Reports Server (NTRS)

1990-01-01

In response to a Presidential directive, NASA has implemented a space policy which actively supports and encourages U.S. industry investment and participation in commercial space ventures. NASA's Office of Commercial Programs (OCP) has played a significant role in stimulating the growth of commercial space activity. Through a variety of programs, OCP encourages commercial interest and involvement in space endeavors by providing access to NASA resources and opportunities for the emerging space industry to reduce the technical, financial, and business risks associated with space-related activities. This manual describes NASA's Commercial Uses of Space Program and introduces participants to four major OCP Commercial programs: Technology Utilization (TU), Small Business Innovation Research (SBIR), Centers for the Commercial Development of Space Flight Agreement (CCDSFA), and Cooperative Agreements Programs. The objective of this manual is to assist U.S. industry identify and pursue the appropriate agreement for participation in a commercial space venture.

Soviet Space Programs: 1976-80 (with Supplementary Data through 1983). Unmanned Space Activities. Part 3. Prepared at the Request of Hon. John C. Danforth, Chairman, Committee on Commerce, Science and Transportation, United States Senate, Ninety-Ninth Congress, First Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Commerce, Science, and Transportation.

This report, the third and final part of a three-part study of Soviet space programs, provides a comprehensive survey of the Soviet space science programs and the Soviet military space programs, including its long history of anti-satellite activity. Chapter 1 is an overview of the unmanned space programs (1957-83). Chapter 2 reports on significant…

Orbital Space Plane (OSP) Program at Lockheed Martin

NASA Technical Reports Server (NTRS)

Ford, Robert

2003-01-01

Lockheed Martin has been an active participant in NASA's Space Launch Initiative (SLI) programs over the past several years. SLI, part of NASA's Integrated Space Transportation Plan (ISTP), was restructured in November 2002 to focus the overall theme of safer, more affordable space transportation along two paths the Orbital Space Plane (OSP) and the Next Generation Launch Technology programs. The Orbital Space Plane program has the goal of providing rescue capability from the International Space Station by 2008 or earlier and transfer capability for crew (and contingency cargo) by 2012. The Next Generation Launch Technology program is combining research and development efforts from the 2d Generation Reusable Launch Vehicle (2GRLV) program with cutting-edge, advanced space transportation programs (previously designated 31d Generation) into one program aimed at enabling safe, reliable, cost-effective reusable launch systems by the middle of the next decade. Lockheed Martin is one of three prime contractors working to bring Orbital Space Plane system concepts to a system design level of maturity by December 2003. This paper and presentation will update the aerospace community on the progress of the OSP program, from an industry perspective, and provide insights into Lockheed Martin's role in enabling the vision of a safer, more affordable means of taking people to and from space.

Classification of Magnetic Nanoparticle Systems—Synthesis, Standardization and Analysis Methods in the NanoMag Project

PubMed Central

Bogren, Sara; Fornara, Andrea; Ludwig, Frank; del Puerto Morales, Maria; Steinhoff, Uwe; Fougt Hansen, Mikkel; Kazakova, Olga; Johansson, Christer

2015-01-01

This study presents classification of different magnetic single- and multi-core particle systems using their measured dynamic magnetic properties together with their nanocrystal and particle sizes. The dynamic magnetic properties are measured with AC (dynamical) susceptometry and magnetorelaxometry and the size parameters are determined from electron microscopy and dynamic light scattering. Using these methods, we also show that the nanocrystal size and particle morphology determines the dynamic magnetic properties for both single- and multi-core particles. The presented results are obtained from the four year EU NMP FP7 project, NanoMag, which is focused on standardization of analysis methods for magnetic nanoparticles. PMID:26343639

Hydrophilic modification of polyethersulfone and its membrane characteristics

NASA Astrophysics Data System (ADS)

Liu, Haiju; Huangfu, Feng-yun; Bai, Yundong; Kong, Yuanyuan

2010-07-01

In order to enhance the hydrophilicity of PES, A series of sulfonated polyethersulfone (SPES) were readily prepared via a reaction of sulphonation which used chlorosulfonic as sulfonating agent and concentrated sulfuric acid as solvent. Sulfonation was confirmed by Fourier transform infrared spectroscopy and Thermo gravimetric analyzer. We studied forming film characteristic of SPES by phase diagram. The sulfonated PES materials were then utilized as a hydrophilic modifier for fabrication of SPES membranes. The solvent was NMP and PEG-6000 was pore-forming agent. The characteristics of membranes were studied. It was found that the surface hydrophilicity of the modified PES membranes was remarkably enhanced by contact angle. Water flux was obvious increased and antifouling performance was also improved.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

The OAST space power program

NASA Technical Reports Server (NTRS)

Bennett, Gary L.

1991-01-01

The NASA Office of Aeronautics and Space Technology (OAST) space power program was established to provide the technology base to meet power system requirements for future space missions, including the Space Station, earth orbiting spacecraft, lunar and planetary bases, and solar system exploration. The program spans photovoltaic energy conversion, chemical energy conversion, thermal energy conversion, power management, thermal management, and focused initiatives on high-capacity power, surface power, and space nuclear power. The OAST space power program covers a broad range of important technologies that will enable or enhance future U.S. space missions. The program is well under way and is providing the kind of experimental and analytical information needed for spacecraft designers to make intelligent decisions about future power system options.

Early Program Development

NASA Image and Video Library

1970-01-01

This 1970 artist's concept illustrates the use of the Space Shuttle, Nuclear Shuttle, and Space Tug in NASA's Integrated Program. As a result of the Space Task Group's recommendations for more commonality and integration in the American space program, Marshall Space Flight Center engineers studied many of the spacecraft depicted here.

Fusion energy for space: Feasibility demonstration. A proposal to NASA

NASA Technical Reports Server (NTRS)

Schulze, Norman R.

1992-01-01

This proposed program is to initiate a space flight research and development program to develop fusion energy for the space applications of direct space propulsion and direct space power, that is, a Space Fusion Energy (SFE) program. 'Direct propulsion' refers to the use of plasma energy directly for thrust without requiring other energy conversion systems. Further, to provide space missions with large electrical power, 'direct space power' is proposed whereby the direct conversion of charged particles into electricity is used, thereby avoiding thermal conversion system losses. The energy release from nuclear fusion reactions makes these highly efficient, high power space systems possible. The program as presented conducts in an orderly, hierarchical manner the necessary planning, analyses, and testing to demonstrate the practical use of fusion energy for space. There is nothing discussed that is known to be theoretically impossible. Validation of the engineering principles is sought in this program which uses a cost-benefit approach. Upon successful program completion, space will become more accessible and space missions more safely conducted. The country will have taken a giant step toward the commercialization of space. The mission enabling capability provided by fusion energy is well beyond mission planners' current dreams.

A Technology Plan for Enabling Commercial Space Business

NASA Technical Reports Server (NTRS)

Lyles, Garry M.

1997-01-01

The National Aeronautics and Space Administration's (NASA) Advanced Space Transportation Program is a customer driven, focused technology program that supports the NASA Strategic Plan and considers future commercial space business projections. The initial cycle of the Advanced Space Transportation Program implementation planning was conducted from December 1995 through February 1996 and represented increased NASA emphasis on broad base technology development with the goal of dramatic reductions in the cost of space transportation. The second planning cycle, conducted in January and February 1997, updated the program implementation plan based on changes in the external environment, increased maturity of advanced concept studies, and current technology assessments. The program has taken a business-like approach to technology development with a balanced portfolio of near, medium, and long-term strategic targets. Strategic targets are influenced by Earth science, space science, and exploration objectives as well as commercial space markets. Commercial space markets include those that would be enhanced by lower cost transportation as well as potential markets resulting in major increases in space business induced by reductions in transportation cost. The program plan addresses earth-to-orbit space launch, earth orbit operations and deep space systems. It also addresses all critical transportation system elements; including structures, thermal protection systems, propulsion, avionics, and operations. As these technologies are matured, integrated technology flight experiments such as the X-33 and X-34 flight demonstrator programs support near-term (one to five years) development or operational decisions. The Advanced Space Transportation Program and the flight demonstrator programs combine business planning, ground-based technology demonstrations and flight demonstrations that will permit industry and NASA to commit to revolutionary new space transportation systems beginning at the turn of the century and continuing far into the future.

Soviet Space Programs: 1976-80 (With Supplementary Data through 1983). Manned Space Programs and Space Life Sciences. Part 2. Prepared at the Request of Hon. Bob Packwood, Chairman, Committee on Commerce, Science, and Transportation, United States Senate, Ninety-Eighth Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Commerce, Science, and Transportation.

This report, the second of a three-part study of Soviet space programs, examines their manned space programs and reviews their quest for a permanently manned presence in space. Also included is information concerning the physiological and psychological findings related to the extended duration of Soviet manned flights and an executive summary.…

KSC-2010-4885

NASA Image and Video Library

2010-09-28

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Bill McArthur, (left) Space Shuttle Program Orbiter Projects manager; John Casper, Assistant Space Shuttle Program manager; John Shannon, Space Shuttle Program manager and Canadian Space Agency astronaut Chris Hadfield attend a ceremony being held to commemorate the move from Kennedy's Assembly Refurbishment Facility (ARF) to the Vehicle Assembly Building (VAB) of the Space Shuttle Program's final solid rocket booster structural assembly -- the right-hand forward. The move was postponed because of inclement weather. Photo credit: NASA/Kim Shiflett

The NASA Space Radiation Health Program

NASA Technical Reports Server (NTRS)

Schimmerling, W.; Sulzman, F. M.

1994-01-01

The NASA Space Radiation Health Program is a part of the Life Sciences Division in the Office of Space Science and Applications (OSSA). The goal of the Space Radiation Health Program is development of scientific bases for assuring adequate radiation protection in space. A proposed research program will determine long-term health risks from exposure to cosmic rays and other radiation. Ground-based animal models will be used to predict risk of exposures at varying levels from various sources and the safe levels for manned space flight.

Current status and future direction of NASA's Space Life Sciences Program

NASA Technical Reports Server (NTRS)

White, Ronald J.; Lujan, Barbara F.

1989-01-01

The elements of the NASA Life Sciences Program that are related to manned space flight and biological scientific studies in space are reviewed. Projects included in the current program are outlined and the future direction of the program is discussed. Consideration is given to issues such as long-duration spaceflight, medical support in space, readaptation to the gravity field of earth, considerations for the Space Station, radiation hazards, environmental standards for space habitation, and human operator interaction with computers, robots, and telepresence systems.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Associate Program Manager of Florida Operations Bill Pickavance (left front) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right front) tour a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Associate Program Manager of Florida Operations Bill Pickavance (left front) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right front) tour a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Space transportation alternatives for large space programs: The International Space University Summer Session, 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

1993-01-01

In 1992, the International Space University (ISU) held its Summer Session in Kitakyushu, Japan. This paper summarizes and expands upon some aspects of space solar power and space transportation that were considered during that session. The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW, or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. A high-cost space transportation program is potentially the most crippling barrier to such a space power program. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed. Over 120 students from 29 countries participated in this summer session. The results discussed in this paper, therefore, represent the efforts of many nations.

DOD Space Test Program (STP)

NASA Technical Reports Server (NTRS)

Smith, Llwyn

1995-01-01

This paper describes the Space Test Program (STP) which provides access to space for the DOD-wide space research and development (R&D) community. STP matches a ranked list of sanctioned experiments with available budgets and searches for the most cost effective mechanisms to get the experiments into space. The program has successfully flown over 350 experiments, using dedicated freeflyer spacecraft, secondary space on the Space Shuttle, and various host satellites.

Free piston space Stirling technology program

NASA Technical Reports Server (NTRS)

Dochat, G. R.; Dhar, M.

1989-01-01

MTI recently completed an initial technology feasibility program for NASA by designing, fabricating and testing a space power demonstrator engine (SPDE). This program, which confirms the potential of free-piston Stirling engines, provided the major impetus to initiate a free-piston Stirling space engine (SSE) technology program. The accomplishments of the SPDE program are reviewed, and an overview of the SSE technology program and technical status to date is provided. It is shown that progress in both programs continues to justify its potential for either nuclear or solar space power missions.

Characterization of the Polyurethanolytic Activity of Two Alicycliphilus sp. Strains Able To Degrade Polyurethane and N-Methylpyrrolidone▿

PubMed Central

Oceguera-Cervantes, Alejandro; Carrillo-García, Agustín; López, Néstor; Bolaños-Nuñez, Sandra; Cruz-Gómez, M. Javier; Wacher, Carmen; Loza-Tavera, Herminia

2007-01-01

Two bacterial strains (BQ1 and BQ8) were isolated from decomposed soft foam. These were selected for their capacity to grow in a minimal medium (MM) supplemented with a commercial surface-coating polyurethane (PU) (Hydroform) as the carbon source (MM-PUh). Both bacterial strains were identified as Alicycliphilus sp. by comparative 16S rRNA gene sequence analysis. Growth in MM-PUh showed hyperbolic behavior, with BQ1 producing higher maximum growth (17.8 ± 0.6 mg·ml−1) than BQ8 (14.0 ± 0.6 mg·ml−1) after 100 h of culture. Nuclear magnetic resonance, Fourier transform infrared (IR) spectroscopy, and gas chromatography-mass spectrometry analyses of Hydroform showed that it was a polyester PU type which also contained N-methylpyrrolidone (NMP) as an additive. Alicycliphilus sp. utilizes NMP during the first stage of growth and was able to use it as the sole carbon and nitrogen source, with calculated Ks values of about 8 mg·ml−1. Enzymatic activities related to PU degradation (esterase, protease, and urease activities) were tested by using differential media and activity assays in cell-free supernatants of bacterial cultures in MM-PUh. Induction of esterase activity in inoculated MM-PUh, but not that of protease or urease activities, was observed at 12 h of culture. Esterase activity reached its maximum at 18 h and was maintained at 50% of its maximal activity until the end of the analysis (120 h). The capacity of Alicycliphilus sp. to degrade PU was demonstrated by changes in the PU IR spectrum and by the numerous holes produced in solid PU observed by scanning electron microscopy after bacterial culture. Changes in the PU IR spectra indicate that an esterase activity is involved in PU degradation. PMID:17693569

[Immediate recurrent laryngeal nerve reconstruction in the treatment of thyroid cancer invading the recurrent laryngeal nerve].

PubMed

Feng, Yun; Yang, Dazhang; Liu, Dandan; Chen, Jian; Bi, Qingling; Luo, Keqiang

2014-08-01

To explore the application of immediate recurrent laryngeal nerve reconstruction in the treatment of thyroid cancer invading the recurrent laryngeal nerve. Ten patients with thyroid cancer invading unilateral recurrent laryngeal nerve underwent radical surgery and immediate recurrent laryngeal nerve reconstruction. The reconstructive surgical approach included recurrent laryngeal nerve decompression surgery, end-to-end anastomosis of the recurrent laryngeal nerve, anastomosis of ansa cervicalis nerve to the recurrent laryngeal nerve, and nerve-muscle pedicle (NMP) technique. Among the ten patients, one underwent nerve decompression, one underwent end-to-end anastomosis of the recurrent laryngeal nerve, seven had anastomosis of ansa cervicalis to recurrent laryngeal nerve, and one case had anastomosis of ansa cervicalis to recurrent laryngeal nerve combined with nerve-muscle pedicle (NMP) technique. The effect of surgery was evaluated by videolaryngoscopy, maximum phonation time (MPT), phonation efficiency index (PEI) and voice assessment. T-test was used in the statistical analysis. All of the 10 patients had no complications including tumor recurrence and hypoparathyroidism after the surgery. Their hoarseness symptoms were improved, and the patients returned to normal or near-normal voice. Postoperative videolaryngoscopy showed that paralyzed vocal cord returned to normal muscle tone and volume, and the vocal cord vibration and mucosal wave were symmetric and the patients got good glottal closure. The pre- and post-operative maximum phone times of the patients were (4.52 ± 0.89) s and (11.91 ± 1.87) s, respectively (P < 0.01). The pre- and post-operative phonation efficiency indices were (1.37 ± 0.43) s/L and (4.02 ± 1.33) s/L, respectively (P < 0.05). In patients with thyroid cancer invading unilateral recurrent laryngeal nerve, immediate recurrent laryngeal nerve reconstruction following radical surgery of thyroid cancer can effectively achieve recovery in phonation function and improve the quality of life of the patients.

Concave Pit-Containing Scaffold Surfaces Improve Stem Cell-Derived Osteoblast Performance and Lead to Significant Bone Tissue Formation

PubMed Central

Cusella-De Angelis, Maria Gabriella; Laino, Gregorio; Piattelli, Adriano; Pacifici, Maurizio; De Rosa, Alfredo; Papaccio, Gianpaolo

2007-01-01

Background Scaffold surface features are thought to be important regulators of stem cell performance and endurance in tissue engineering applications, but details about these fundamental aspects of stem cell biology remain largely unclear. Methodology and Findings In the present study, smooth clinical-grade lactide-coglyolic acid 85:15 (PLGA) scaffolds were carved as membranes and treated with NMP (N-metil-pyrrolidone) to create controlled subtractive pits or microcavities. Scanning electron and confocal microscopy revealed that the NMP-treated membranes contained: (i) large microcavities of 80–120 µm in diameter and 40–100 µm in depth, which we termed primary; and (ii) smaller microcavities of 10–20 µm in diameter and 3–10 µm in depth located within the primary cavities, which we termed secondary. We asked whether a microcavity-rich scaffold had distinct bone-forming capabilities compared to a smooth one. To do so, mesenchymal stem cells derived from human dental pulp were seeded onto the two types of scaffold and monitored over time for cytoarchitectural characteristics, differentiation status and production of important factors, including bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF). We found that the microcavity-rich scaffold enhanced cell adhesion: the cells created intimate contact with secondary microcavities and were polarized. These cytological responses were not seen with the smooth-surface scaffold. Moreover, cells on the microcavity-rich scaffold released larger amounts of BMP-2 and VEGF into the culture medium and expressed higher alkaline phosphatase activity. When this type of scaffold was transplanted into rats, superior bone formation was elicited compared to cells seeded on the smooth scaffold. Conclusion In conclusion, surface microcavities appear to support a more vigorous osteogenic response of stem cells and should be used in the design of therapeutic substrates to improve bone repair and bioengineering applications in the future. PMID:17551577

Contrasting above- and belowground sensitivity of three Great Plains grasslands to altered rainfall regimes.

PubMed

Wilcox, Kevin R; von Fischer, Joseph C; Muscha, Jennifer M; Petersen, Mark K; Knapp, Alan K

2015-01-01

Intensification of the global hydrological cycle with atmospheric warming is expected to increase interannual variation in precipitation amount and the frequency of extreme precipitation events. Although studies in grasslands have shown sensitivity of aboveground net primary productivity (ANPP) to both precipitation amount and event size, we lack equivalent knowledge for responses of belowground net primary productivity (BNPP) and NPP. We conducted a 2-year experiment in three US Great Plains grasslands--the C4-dominated shortgrass prairie (SGP; low ANPP) and tallgrass prairie (TGP; high ANPP), and the C3-dominated northern mixed grass prairie (NMP; intermediate ANPP)--to test three predictions: (i) both ANPP and BNPP responses to increased precipitation amount would vary inversely with mean annual precipitation (MAP) and site productivity; (ii) increased numbers of extreme rainfall events during high-rainfall years would affect high and low MAP sites differently; and (iii) responses belowground would mirror those aboveground. We increased growing season precipitation by as much as 50% by augmenting natural rainfall via (i) many (11-13) small or (ii) fewer (3-5) large watering events, with the latter coinciding with naturally occurring large storms. Both ANPP and BNPP increased with water addition in the two C4 grasslands, with greater ANPP sensitivity in TGP, but greater BNPP and NPP sensitivity in SGP. ANPP and BNPP did not respond to any rainfall manipulations in the C3 -dominated NMP. Consistent with previous studies, fewer larger (extreme) rainfall events increased ANPP relative to many small events in SGP, but event size had no effect in TGP. Neither system responded consistently above- and belowground to event size; consequently, total NPP was insensitive to event size. The diversity of responses observed in these three grassland types underscores the challenge of predicting responses relevant to C cycling to forecast changes in precipitation regimes even within relatively homogeneous biomes such as grasslands. © 2014 John Wiley & Sons Ltd.

Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound.

PubMed

Phaechamud, Thawatchai; Yodkhum, Kotchamon; Charoenteeraboon, Juree; Tabata, Yasuhiko

2015-05-01

There are many factors that delay healing in chronic wounds including lowering level of growth factors and increasing exudate level comprising high amount of tissue destructive enzymes. Asiaticoside possesses interesting wound healing and angiogenic activities that are employed to stimulate tissue regeneration in wound healing application. This study attempted to develop chitosan-aluminum monostearate (Alst) composite sponge containing asiaticoside for use as an absorbent medical dressing in chronic wound. N-methyl-2-pyrrolidone (NMP) was used to enhance homogeneity of asiaticoside in the polymer composite matrix. The sponge dressings were prepared by lyophilization and dehydrothermal treatment (DHT). Functional group interaction, crystallinity, and morphology of the prepared sponges were investigated using FT-IR, PXRD, and SEM, respectively. Physicochemical properties, porosity, hydrophilic/hydrophobic properties and mechanical property, were evaluated. Wound dressing properties, water vapor transmission rate (WVTR), fluid absorbency, oxygen permeation (OP), and bio-adhesive property, were investigated. In vitro asiaticoside release study was conducted using immersion method. Cytotoxicity was studied in normal human dermal fibroblast (NHDF) and normal human epidermal keratinocyte (NHEK). Angiogenic activity of asiaticoside was evaluated using chick-chorioallantoic membrane (CAM) assay. FT-IR and PXRD results revealed the amidation after DHT to enhance the crystallinity of the prepared sponges. The prepared sponges had high porosity comprising high Alst-loaded amount that exhibited more compact structure. Alst enhanced hydrophobicity therefore it reduced the fluid absorption and WVTR together with bio-adhesion of the prepared sponge dressings. Porosity of all sponges was more than 85% therefore resulting in their high OP. Enhancing hydrophobicity of the material by Alst and more homogeneity caused by NMP eventually retarded the asiaticoside release for 7 days. The sponge extractions were non-toxic to the cells moreover they promoted NHDF and NHEK cell proliferation. Asiaticoside and asiaticoside-contained dressings exhibited dose-dependent angiogenic activity in CAM model. Copyright © 2015 Elsevier B.V. All rights reserved.

Microbiological determinations of some vegetables from the Xochimilco zone in Mexico City, Mexico.

PubMed

García-Gómez, Rolando; Chávez-Espinosa, José; Mejía-Chávez, Adriana; Duránde-Bazúa, Carmen

2002-01-01

Vegetables intake is widely recommended because of its high content of vitamins, minerals and fiber. However, the irrigation of these vegetables, using wastewaters that have received inadequate treatment often carries unseen microbial pollution that becomes a high risk potential for humans. In the present research, two of the most consumed fresh vegetables cultivated in Mexico City were analyzed, lettuce (Lactuca sativa) and Mexican coriander (Eryngium foetidum). These vegetables are commonly consumed raw. The vegetable choice and the disinfection's method were carried out by the application of two tests to two hundred people in an aleatory form. Similarly, vegetable sampling was carried out by means of a random sampling from the cultivated areas in a chosen "chinampa" (from Náhuatl or Aztec, chinamitl, bulrush or cattail stalks lattice for hydroponics cultivation). Vegetable samples were transferred, in dark plastic bags and in cool boxes at 4 +/- 1.5 degrees C, to the laboratory. Microbiological analysis for Salmonella typhi, mesophilic microorganisms, and fecal coliforms were done according to the "NOM-093SSA1-1994" (Mexico). Results obtained demonstrated that samples treated with the most preferred disinfectant, a colloidal silver based one, had a partial elimination of pathogenic microorganisms found in both vegetables lettuce (Lactuca sativa) and coriander (Eryngium foetidum) samples (mesophyllic microorganisms from 200,000 to 96,500 UFC/g and from 175,000 to 125,000 UFC/g and fecal coliforms from 75 to 0.43 NMP/g and from 150 to 2.10 NMP/g, respectively). Salmonella typhi for all samples gave a positive result. Therefore, it was recommended to the cultivators of the Xochimilco (Náhuatl or Aztec name that means "place where flowers bloom") zone, either stop using contaminated water for irrigation or to use more efficient methods in order to eliminate pathogenic microorganisms, such as diluted chlorine solutions made with commercial cotton clothing bleachers.

Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with β-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii.

PubMed

Lee, Spencer; Razqan, Ghaida Saleh Al; Kwon, Dong H

2017-01-15

Infections caused by Acinetobacter baumannii were responsive to conventional antibiotic therapy. However, recently, carbapenem-associated multidrug resistant isolates have been reported worldwide and present a major therapeutic challenge. Epigallocatechin-3-Gallate (EGCG) extracted from green tea exhibits antibacterial activity. We evaluated the antibacterial activity of EGCG and possible synergism with antibiotics in carbapenem-associated multidrug resistant A. baumannii. A potential mechanism for synergism was also explored. Seventy clinical isolates of A. baumannii collected from geographically different areas were analyzed by minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of EGCG. Checkerboard and time-killing assays were performed to exam the synergism between EGCG and antibiotics. The effects of EGCG on a multidrug efflux pump inhibitor (1-[1-naphthylmethyl] piperazine; NMP) and β-lactamase production were also examined in A. baumannii. Sixty-three of 70 clinical isolates of A. baumannii carried carbapenemase-encoding genes with carbapenem-associated multidrug resistance. Levels of MIC and MBC of EGCG ranged from 64 to 512µg/ml and from 128 to ≥1024µg/ml, respectively among the clinical isolates. MIC 90 and MBC 86 levels were 256µg/ml and 512µg/ml of EGCG, respectively. Subinhibitory concentration of EGCG in combination with all antibiotics tested, including carbapenem, sensitized (MICs fall≤1.0µg/ml) all carbapenem-associated multidrug resistant isolates. Checkerboard and time-killing assays showed synergism between EGCG and meropenem (or carbenicillin) counted as fractional inhibitory concentration of < 0.5 and cell numbers' decrease per ml of >2log10 within 12h, respectively. EGCG significantly increased the effect of NMP but was unrelated to β-lactamase production in A. baumannii, suggesting EGCG may be associated with inhibition of efflux pumps. Overall we suggest that EGCG-antibiotic combinations might provide an alternative approach to treat infections with A. baumannii regardless of antibiotic resistance. Copyright © 2016 Elsevier GmbH. All rights reserved.

Total biosynthesis of deoxynucleoside triphosphates using deoxynucleoside monophosphate kinases for PCR application.

PubMed

Bao, Jie; Ryu, Dewey D Y

2007-09-01

Polymerase chain reaction (PCR) and other PCR applications for DNA synthesis require deoxynucleoside triphosphates (dNTP) as the essential precursors and substrates. Currently, the dNTP is commercially produced by a chemical method which is environmentally hazardous and costly due to its low yields in both the synthetic reaction and purification processes. In this study, a enzyme technology for the total integrated biosynthesis of all dNTP components is presented. The bioprocess technology developed and reported here involves two sequential enzymatic phosphorylation reactions coupled with the cofactor regeneration starting from deoxynucleoside monophosphates (dNMP) to deoxynucleoside diphosphates (dNDP) in the first reaction step and to dNTP in the second reaction step in the same bioreactor. The four genes encoding these deoxynucleoside monophosphate kinases were cloned into the recombinant E. coli and expressed using the recombinant E. coli strains. The reaction mechanisms and kinetics of the four kinase enzymes are studied and reported. The total enzymatic syntheses of the four dNTP products were carried out in four separate operations under the high substrate concentrations which emulate the practical application. The optimal process conditions were carefully investigated and complete conversion of dNMP to dNTP at high substrate concentration have been achieved. The purity and quality of dNTP products obtained from this work were analyzed and found to be at least equivalent or better than the commercially available dNTP products. The PCR application of dNTP products obtained from this work were also evaluated for isolating and amplifying genes of different sizes from different organisms. The PCR performance test also showed an equivalent quality as compared to the commercially available dNTP. The bioprocess technology developed and reported here for production of dNTP will provide economically competitive and environmentally friendly viable technology for the industry and research community as compared to the chemical technology currently in use.

KSC-2013-2647

NASA Image and Video Library

2013-06-11

CAPE CANAVERAL, Fla. - NASA Commercial Crew Program, or CCP, partner representatives participate in the National Space Club Florida Committee's June meeting near the Kennedy Space Center. From left are The Boeing Company's vice president and program manager of Commercial Programs John Mulholland, Sierra Nevada Corporation, or SNC, Space Systems chief systems engineer Dan Ciccateri, and Space Exploration Technologies, or SpaceX, vice president of government sales Adam Harris. CCP Program Manager Ed Mango and the partners talked about plans to increase commercial activities on Florida’s space coast to send astronauts to low-Earth orbit. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro are briefed on the properties of the tile used in the Shuttle's Thermal Protection System (TPS) by USA Manager of the TPS Facility Martin Wilson (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro are briefed on the properties of the tile used in the Shuttle's Thermal Protection System (TPS) by USA Manager of the TPS Facility Martin Wilson (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Organization and management of space grant programs

NASA Technical Reports Server (NTRS)

Sheppard, Sallie; Nichols, Steve

1990-01-01

The 21 Space Grant Programs represent a broad range of organizational structures which operate programs ranging in size from single university organizations to organizations including up to 41 members involving a composite of industrial organizations such as state agencies, and universities. Some of the space grant awards were made to organizations already in existence with on-going programs while other awards were made to consortia newly formed for the purpose of applying to the Space Grant Program. The workshop on organization and management of Space Grant Programs provided an opportunity for directors and program representatives to discuss and compare the relative advantages and disadvantages of the various models being used. This paper offers examples of the diversity of organizations, summarizes the common concerns to be met by each organizational model, and provides a case study of the Texas Space Grant Consortium organization.

Opportunities and the Perception Ofspace Programs in the Developing Countries

NASA Astrophysics Data System (ADS)

Abubakar, B. G.

2006-08-01

Although the space program as a whole is a true reflection of the level of achievement in human history in the field of Science and Technology, but it is also important to note that there are numbers of communities and societies on this earth that are ignorant about this great achievement, hence leading to the continuous diverting of Potential Astronomers, Aerospace Engineers and Astrologist to other disciplines, thereby undermining the development of the space program over time. It was in view of the above that this research was conducted and came up with the under listed Suggestions/Recommendations:- 1. The European Space Agency (ESA), National Aeronautic Space Agency (NASA) and the Russian Space Agency, should be organising and sponsoring public enlightenment conferences, seminars and workshops towards creating awareness and attracting Potential Astronomers and other Space Scientist mostly in the developing countries into the space program. 2. Esteemed organisations in space programs like NASA, ESA and others should be awarding scholarships to potential space scientist that lack the financial capability to pursue studies in the field of space science from the developing countries. 3. The European Space Agency, National Aeronautic Space Agency and the Russian Space Agency, should open their offices for the development of the space program in the third world countries. I believe that if the above suggestions/recommendations are adopted and implemented it will lead to the development of the space program in general, otherwise the rate at which potential Astronomers, Aerospace Engineers and Astrologists will be diverting into other disciplines will ever remain on the increase.

Fabrication of Polyimide-Matrix/Carbon and Boron-Fiber Tape

NASA Technical Reports Server (NTRS)

Belvin, Harry L.; Cano, Roberto J.; Treasure, Monte; Shahood, Thomas W.

2007-01-01

The term HYCARB denotes a hybrid composite of polyimide matrices reinforced with carbon and boron fibers. HYCARB and an improved process for fabricating dry HYCARB tapes have been invented in a continuing effort to develop lightweight, strong composite materials for aerospace vehicles. Like other composite tapes in this line of development, HYCARB tapes are intended to be used to build up laminated structures having possibly complex shapes by means of automated tow placement (ATP) - a process in which a computer-controlled multiaxis machine lays down prepreg tape or tows. The special significance of the present process for making dry HYCARB for ATP is that it contributes to the reduction of the overall cost of manufacturing boron-reinforced composite-material structures while making it possible to realize increased compression strengths. The present process for making HYCARB tapes incorporates a "wet to dry" process developed previously at Langley Research Center. In the "wet to dry" process, a flattened bundle of carbon fiber tows, pulled along a continuous production line between pairs of rollers, is impregnated with a solution of a poly(amide acid) in N-methyl-2-pyrrolidinone (NMP), then most of the NMP is removed by evaporation in hot air. In the present case, the polyamide acid is, more specifically, that of LaRC. IAX (or equivalent) thermoplastic polyimide, and the fibers are, more specifically, Manganite IM7 (or equivalent) polyacrylonitrile- based carbon filaments that have a diameter of 5.2 m and are supplied in 12,000-filament tows. The present process stands in contrast to a prior process in which HYCARB tape was made by pressing boron fibers into the face of a wet carbon-fiber/ poly(amide acid) prepreg tape . that is, a prepreg tape from which the NMP solvent had not been removed. In the present process, one or more layer(s) of side-by-side boron fibers are pressed between dry prepreg tapes that have been prepared by the aforementioned gwet to dry h process. The multilayer tape is then heated to imidize the matrix material and remove most of the remaining solvent, and is pressed to consolidate the multiple layers into a dense tape. For tests, specimens of HYCARB tapes and laminated composite panels made from HYCARB tape were prepared as follows: HYCARB tapes were fabricated as described above. Each panel was made by laying down ten layers of tape, containing, variously, one, two, or three boron-fiber plies and the remainder carbon- fiber-only plies (see figure). Each panel was made by laying down ten layers of tape. Each panel was then cured by heating to a temperature of 225 C for 15 minutes, then pressing at 200 psi (A1.4 MPa) while heating to 371 C, holding at 371 C for 1 hour, then continuing to hold pressure during cooling. Control specimens that were otherwise identical except that they did not contain boron fibers also were prepared. In room-temperature flexural tests, the HYCARB specimens performed comparably to the control specimens; in room-temperature, open-hole compression tests, the HYCARB specimens performed slightly better, by amounts that increased with boron content.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schulze, N.R.

This proposed program is to initiate a space flight research and development program to develop fusion energy for the space applications of direct space propulsion and direct space power, that is, a Space Fusion Energy (SFE) program. 'Direct propulsion' refers to the use of plasma energy directly for thrust without requiring other energy conversion systems. Further, to provide space missions with large electrical power, 'direct space power' is proposed whereby the direct conversion of charged particles into electricity is used, thereby avoiding thermal conversion system losses. The energy release from nuclear fusion reactions makes these highly efficient, high power spacemore » systems possible. The program as presented conducts in an orderly, hierarchical manner the necessary planning, analyses, and testing to demonstrate the practical use of fusion energy for space. There is nothing discussed that is known to be theoretically impossible. Validation of the engineering principles is sought in this program which uses a cost-benefit approach. Upon successful program completion, space will become more accessible and space missions more safely conducted. The country will have taken a giant step toward the commercialization of space. The mission enabling capability provided by fusion energy is well beyond mission planners' current dreams.« less

Applications notice. [application of space techniques to earth resources, environment management, and space processing

NASA Technical Reports Server (NTRS)

1978-01-01

The discipline programs of the Space and Terrestrial (S&T) Applications Program are described and examples of research areas of current interest are given. Application of space techniques to improve conditions on earth are summarized. Discipline programs discussed include: resource observations; environmental observations; communications; materials processing in space; and applications systems/information systems. Format information on submission of unsolicited proposals for research related to the S&T Applications Program are given.

Methodologies for optimal resource allocation to the national space program and new space utilizations. Volume 1: Technical description

NASA Technical Reports Server (NTRS)

1971-01-01

The optimal allocation of resources to the national space program over an extended time period requires the solution of a large combinatorial problem in which the program elements are interdependent. The computer model uses an accelerated search technique to solve this problem. The model contains a large number of options selectable by the user to provide flexible input and a broad range of output for use in sensitivity analyses of all entering elements. Examples of these options are budget smoothing under varied appropriation levels, entry of inflation and discount effects, and probabilistic output which provides quantified degrees of certainty that program costs will remain within planned budget. Criteria and related analytic procedures were established for identifying potential new space program directions. Used in combination with the optimal resource allocation model, new space applications can be analyzed in realistic perspective, including the advantage gain from existing space program plant and on-going programs such as the space transportation system.

Space Shuttle utilization characteristics with special emphasis on payload design, economy of operation and effective space exploitation

NASA Technical Reports Server (NTRS)

Turner, D. N.

1981-01-01

The reusable manned Space Shuttle has made new and innovative payload planning a reality and opened the door to a variety of payload concepts formerly unavailable in routine space operations. In order to define the payload characteristics and program strategies, current Shuttle-oriented programs are presented: NASA's Space Telescope, the Long Duration Exposure Facility, the West German Shuttle Pallet Satellite, and the Goddard Space Flight Center's Multimission Modular Spacecraft. Commonality of spacecraft design and adaptation for specific mission roles minimizes payload program development and STS integration costs. Commonality of airborne support equipment assures the possibility of multiple program space operations with the Shuttle. On-orbit maintenance and repair was suggested for the module and system levels. Program savings from 13 to over 50% were found obtainable by the Shuttle over expendable launch systems, and savings from 17 to 45% were achievable by introducing reuse into the Shuttle-oriented programs.

The advanced orbiting systems testbed program: Results to date

NASA Technical Reports Server (NTRS)

Newsome, Penny A.; Otranto, John F.

1993-01-01

The Consultative Committee for Space Data Systems Recommendations for Packet Telemetry and Advanced Orbiting Systems (AOS) propose standard solutions to data handling problems common to many types of space missions. The Recommendations address only space/ground and space/space data handling systems. Goddard Space Flight Center's AOS Testbed (AOST) Program was initiated to better understand the Recommendations and their impact on real-world systems, and to examine the extended domain of ground/ground data handling systems. Central to the AOST Program are the development of an end-to-end Testbed and its use in a comprehensive testing program. Other Program activities include flight-qualifiable component development, supporting studies, and knowledge dissemination. The results and products of the Program will reduce the uncertainties associated with the development of operational space and ground systems that implement the Recommendations. The results presented in this paper include architectural issues, a draft proposed standardized test suite and flight-qualifiable components.

Space shuttle requirements/configuration evolution

NASA Technical Reports Server (NTRS)

Andrews, E. P.

1991-01-01

Space Shuttle chronology; Space Shuttle comparison; Cost comparison; Performance; Program ground rules; Sizing criteria; Crew/passenger provisions; Space Shuttle Main Engine (SSME) characteristics; Space Shuttle program milestones; and Space Shuttle requirements are outlined. This presentation is represented by viewgraphs.

United States Civil Space Policy: Summary of a Workshop

NASA Technical Reports Server (NTRS)

2008-01-01

What are the principal purposes, goals, and priorities of the U.S. civil space program? This question was the focus of the workshop on civil space policy held November 29-30, 2007, by the Space Studies Board (SSB) and the Aeronautics and Space Engineering Board (ASEB) of the National Research Council (NRC). In addressing this question, invited speakers and panelists and the general discussion from this public workshop explored a series of topics, including the following: (1) Key changes and developments in the U.S. civil space program since the new national Vision for Space Exploration2 (the Vision) was articulated by the executive branch in 2004; (2) The fit of space exploration within a broader national and international context; (3) Affordability, public interest, and political will to sustain the civil space program; (4) Definitions, metrics, and decision criteria for the mix and balance of activities within the program portfolio; (5) Roles of government in Earth observations from space; and (6) Gaps in capabilities and infrastructure to support the program.

Space Shuttle Strategic Planning Status

NASA Technical Reports Server (NTRS)

Henderson, Edward M.; Norbraten, Gordon L.

2006-01-01

The Space Shuttle Program is aggressively planning the Space Shuttle manifest for assembling the International Space Station and servicing the Hubble Space Telescope. Implementing this flight manifest while concurrently transitioning to the Exploration architecture creates formidable challenges; the most notable of which is retaining critical skills within the Shuttle Program workforce. The Program must define a strategy that will allow safe and efficient fly-out of the Shuttle, while smoothly transitioning Shuttle assets (both human and facility) to support early flight demonstrations required in the development of NASA s Crew Exploration Vehicle (CEV) and Crew and Cargo Launch Vehicles (CLV). The Program must accomplish all of this while maintaining the current level of resources. Therefore, it will be necessary to initiate major changes in operations and contracting. Overcoming these challenges will be essential for NASA to fly the Shuttle safely, accomplish the President s "Vision for Space Exploration," and ultimately meet the national goal of maintaining a robust space program. This paper will address the Space Shuttle Program s strategy and its current status in meeting these challenges.

Space Shuttle Strategic Planning Status

NASA Technical Reports Server (NTRS)

Norbraten, Gordon L.; Henderson, Edward M.

2007-01-01

The Space Shuttle Program is aggressively flying the Space Shuttle manifest for assembling the International Space Station and servicing the Hubble Space Telescope. Completing this flight manifest while concurrently transitioning to the Exploration architecture creates formidable challenges; the most notable of which is retaining critical skills within the Shuttle Program workforce. The Program must define a strategy that will allow safe and efficient fly-out of the Shuttle, while smoothly transitioning Shuttle assets (both human and facility) to support early flight demonstrations required in the development of NASA's Crew Exploration Vehicle (Orion) and Crew and Cargo Launch Vehicles (Ares I). The Program must accomplish all of this while maintaining the current level of resources. Therefore, it will be necessary to initiate major changes in operations and contracting. Overcoming these challenges will be essential for NASA to fly the Shuttle safely, accomplish the Vision for Space Exploration, and ultimately meet the national goal of maintaining a robust space program. This paper will address the Space Shuttle Program s strategy and its current status in meeting these challenges.

The NASA Space Radiation Research Program

NASA Technical Reports Server (NTRS)

Cucinotta, Francis A.

2006-01-01

We present a comprehensive overview of the NASA Space Radiation Research Program. This program combines basic research on the mechanisms of radiobiological action relevant for improving knowledge of the risks of cancer, central nervous system and other possible degenerative tissue effects, and acute radiation syndromes from space radiation. The keystones of the NASA Program are five NASA Specialized Center's of Research (NSCOR) investigating space radiation risks. Other research is carried out through peer-reviewed individual investigations and in collaboration with the US Department of Energies Low-Dose Research Program. The Space Radiation Research Program has established the Risk Assessment Project to integrate data from the NSCOR s and other peer-reviewed research into quantitative projection models with the goals of steering research into data and scientific breakthroughs that will reduce the uncertainties in current risk projections and developing the scientific knowledge needed for future individual risk assessment approaches and biological countermeasure assessments or design. The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory was created by the Program to simulate space radiation on the ground in support of the above research programs. New results from NSRL will be described.

Need for closer interaction between Space Science Education and Exploration programs in Developing Countries

NASA Astrophysics Data System (ADS)

Singh, R. N.

Space science has become a subject of prime interest. Important issue is the involvement of major expenditures. For overcoming this problem a global co-operation has developed and is proving to be successful. Space programs in developing countries have not yet started in the true sense. India is very well known as one of the pioneering countries for its contribution to upper atmospheric research that was initiated and grew on University campuses. With the advent of space research, the rocket launching facilities were developed and it was used by various scientists groups from many countries. India has developed capability of rocket and satellite launching. With development of space commission, the ground-based study programs spread all over India have decayed slowly. The space research programs are run by governmental agencies only. Universities that initiated space research programs using ground-based radio waves are out of business. Space research has not yet entered the teaching curricula in Indian Universities. It is high time that the teaching and laboratory work in space research be initiated in Indian universities. Development of such a system is emphasized. Its development would enable university's scientists to participate in Indian space research programs on equal footing as commonly seen in American, European, Russian and Japanese programs.

Space Operations Center system analysis study extension. Volume 2: Programmatics and cost

NASA Technical Reports Server (NTRS)

1982-01-01

A summary of Space Operations Center (SOC) orbital space station costs, program options and program recommendations is presented. Program structure, hardware commonality, schedules and program phasing are considered. Program options are analyzed with respect to mission needs, design and technology options, and anticipated funding constraints. Design and system options are discussed.

Space Product Development: Bringing the Benefits of Space Down to Earth

NASA Technical Reports Server (NTRS)

Allen, Rosalie W.; Tygielski, Andrew; Gabris, Edward A.

1997-01-01

The newly developed microgravity Research Program Office was created to consolidate and integrate NASA's microgravity research efforts, comprised of the microgravity Science and Applications Program and Space Product Development Program. This resulted in an integrated agency program serving the science and industrial research communities, providing leadership, management, direction and overview of all agency microgravity research activities. This paper provides an overview of NASA's microgravity Research Program, with particular emphasis on the Space Product Development Program activities, the potential economic impact and quality of life improvements resulting from this research, and future plans for commercial microgravity research in space. The goal of the Space Product Development Program is to facilitate the use of space for commercial products and services. The unique attributes of space are exploited to conduct industry driven research in the areas of crystallography, bio-systems, agriculture, electronic and non-electronic materials. Industry uses the knowledge gained from focused space research to create new products and processes, to gain economic competitive advantages, to create new jobs and improve the quality of life on earth. The objectives of the program are implemented through NASA's Commercial Space Centers, non-profit consortia of industry, academia and government, that provide the mechanism for communication and technical expert exchange between NASA and industry. Over 200 commercial research activities have been conducted by the Commercial Space Centers and their industrial affiliates over the last four and one-half years during Space Shuttle mission, as well as sounding rocket flights. The results of this research will have a significant impact on competitive products, jobs and quality of life improvements.

MSFC Space Station Program Commonly Used Acronyms and Abbreviations Listing

NASA Technical Reports Server (NTRS)

Gates, Thomas G.

1988-01-01

The Marshall Space Flight Center maintains an active history program to assure that the foundation of the Center's history is captured and preserved for current and future generations. As part of that overall effort, the Center began a project in 1987 to capture historical information and documentation on the Marshall Center's roles regarding Space Shuttle and Space Station. This document is MSFC Space Station Program Commonly Used Acronyms and Abbreviations Listing. It contains acronyms and abbreviations used in Space Station documentation and in the Historian Annotated Bibliography of Space Station Program. The information may be used by the researcher as a reference tool.

Space Station - An integrated approach to operational logistics support

NASA Technical Reports Server (NTRS)

Hosmer, G. J.

1986-01-01

Development of an efficient and cost effective operational logistics system for the Space Station will require logistics planning early in the program's design and development phase. This paper will focus on Integrated Logistics Support (ILS) Program techniques and their application to the Space Station program design, production and deployment phases to assure the development of an effective and cost efficient operational logistics system. The paper will provide the methodology and time-phased programmatic steps required to establish a Space Station ILS Program that will provide an operational logistics system based on planned Space Station program logistics support.

KSC-2013-3517

NASA Image and Video Library

2013-09-09

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center Visitor Complex in Florida, officials pose at the site where a Shuttle Program time capsule has been secured vault within the walls of the Space Shuttle Atlantis home at the Kennedy Space Center Visitor Complex. From the left are: Pete Nickolenko, deputy director of NASA Ground Processing at Kennedy, Patty Stratton of Abacus Technology, currently program manager for the Information Management Communications Support Contract. During the Shuttle Program she was deputy director of Ground Operations for NASA's Space Program Operations Contractor, United Space Alliance, Rita Wilcoxon, NASA's now retired director of Shuttle Processing, Bob Cabana, director of the Kennedy Space Center and George Jacobs, deputy director of Center Operations, who was manager of the agency's Shuttle Transition and Retirement Project Office. The time capsule, containing artifacts and other memorabilia associated with the history of the program is designated to be opened on the 50th anniversary of the shuttle's final landing, STS-135. The new $100 million "Space Shuttle Atlantis" facility includes interactive exhibits that tell the story of the 30-year Space Shuttle Program and highlight the future of space exploration. Photo credit: NASA/Jim Grossmann

Space Science Research and Technology at NASA's Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Johnson, Charles L.

2007-01-01

This presentation will summarize the various projects and programs managed in the Space Science Programs and Projects Office at NASA's Marshall Space Flight Center in Huntsville, Alabama. Projects in the portfolio include NASA's Chandra X-Ray telescope, Hinode solar physics satellite, various advanced space propulsion technologies, including solar sails and tethers, as well as NASA's Discovery and New Frontiers Programs.

The impact of industry/university consortia programs on space education

NASA Technical Reports Server (NTRS)

Page, John R.; Stone, Barbara A.

1993-01-01

The paper describes the industry/university consortia programs established by the United States and Australia and examines these programs from the viewpoint of their impact on space education in their respective countries. Particular attention is given to the aim and the nature of the three programs involved: the Centers for the Commercial Development of Space (CCDSs) (funded by NASA), which are currently involving about 250 companies and 88 universities as participants; the Space Industry Development Centers (SIDCs) (funded by the Australian Space Office): and the Cooperative Research Centers (CRCs) (funded by the Federal Government), which are not limited to the space area but are open to activities ranging from medical research to waste-water treatment. It is emphasized that, while the main aim of the CCDS, SIDC, and CRC programs is to develop space expertise, space education is a very significant byproduct of the activity of these agencies.

International Space Weather Initiative (ISWI)

NASA Technical Reports Server (NTRS)

Gopalswamy, Nat; Davila, Joseph M.

2010-01-01

The International Space Weather Initiative (ISWI) is an international scientific program to understand the external drivers of space weather. The science and applications of space weather has been brought to prominence because of the rapid development of space based technology that is useful for all human beings. The ISWI program has its roots in the successful International Heliophysical Year (IHY) program that ran during 2007 - 2009. The primary objective of the ISWI program is to advance the space weather science by a combination of instrument deployment, analysis and interpretation of space weather data from the deployed instruments in conjunction with space data, and communicate the results to the public and students. Like the IHY, the ISWI will be a grass roots organization with key participation from national coordinators in cooperation with an international steering committee. This talk outlines the ISWI program including its organization and proposed activities.

Artificial intelligence - NASA. [robotics for Space Station

NASA Technical Reports Server (NTRS)

Erickson, J. D.

1985-01-01

Artificial Intelligence (AI) represents a vital common space support element needed to enable the civil space program and commercial space program to perform their missions successfully. It is pointed out that advances in AI stimulated by the Space Station Program could benefit the U.S. in many ways. A fundamental challenge for the civil space program is to meet the needs of the customers and users of space with facilities enabling maximum productivity and having low start-up costs, and low annual operating costs. An effective way to meet this challenge may involve a man-machine system in which artificial intelligence, robotics, and advanced automation are integrated into high reliability organizations. Attention is given to the benefits, NASA strategy for AI, candidate space station systems, the Space Station as a stepping stone, and the commercialization of space.

Space Resource Roundtable Rationale

NASA Astrophysics Data System (ADS)

Duke, Michael

1999-01-01

Recent progress in the U.S. Space Program has renewed interest in space resource issues. The Lunar Prospector mission conducted in NASA's Discovery Program has yielded interesting new insights into lunar resource issues, particularly the possibility that water is concentrated in cold traps at the lunar poles. This finding has not yet triggered a new program of lunar exploration or development, however it opens the possibility that new Discovery Missions might be viable. Several asteroid missions are underway or under development and a mission to return samples from the Mars satellite, Phobos, is being developed. These exploration missions are oriented toward scientific analysis, not resource development and utilization, but can provide additional insight into the possibilities for mining asteroids. The Mars Surveyor program now includes experiments on the 2001 lander that are directly applicable to developing propellants from the atmosphere of Mars, and the program has solicited proposals for the 2003/2005 missions in the area of resource utilization. These are aimed at the eventual human exploration of Mars. The beginning of construction of the International Space Station has awakened interest in follow-on programs of human exploration, and NASA is once more studying the human exploration of Moon, Mars and asteroids. Resource utilization will be included as objectives by some of these human exploration programs. At the same time, research and technology development programs in NASA such as the Microgravity Materials Science Program and the Cross-Enterprise Technology Development Program are including resource utilization as a valid area for study. Several major development areas that could utilize space resources, such as space tourism and solar power satellite programs, are actively under study. NASA's interests in space resource development largely are associated with NASA missions rather than the economic development of resources for industrial processes. That is why there is an emphasis in NASA programs on propellant production on Mars - NASA plans missions to Mars, so could make use of those propellants. For other types of applications, however, it will be up to market forces to define the materials and products needed and develop the technologies for extracting them from space resources. Some leading candidates among the potential products from space resources are propellants for other space activities, water from the Moon for use in space, silicon for photovoltaic energy collection in space, and, eventually, He-3 from the Moon for fusion energy production. As the capabilities for manufacturing materials in space are opened up by research aboard the International Space Station, new opportunities for utilization of space resources may emerge. Whereas current research emphasizes increasing knowledge, one program objective should be the development of industrial production techniques for space. These will be based on the development of value-added processing in space, where materials are brought to the space facility, processed there, and returned to Earth. If enough such space processing is developed that the materials transportation requirements are measured in the hundreds of tons a year level, opportunities for substituting lunar materials may develop. The fundamental message is that it is not possible to develop space resources in a vacuum. One must have three things: a recoverable resource, technology to recover it, and a customer. Of these, the customer probably is the most important. All three must be integrated in a space resource program. That is what the Space Resource Roundtable, initiated with this meeting, will bring together.

NASA Human Research Program Space Radiation Program Element

NASA Technical Reports Server (NTRS)

Chappell, Lori; Huff, Janice; Patel, Janapriya; Wang, Minli; Hu, Shaowwen; Kidane, Yared; Myung-Hee, Kim; Li, Yongfeng; Nounu, Hatem; Plante, Ianik;

Space transportation alternatives for large space programs - The International Space University summer session - 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

1993-01-01

The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group at the International Space University (ISU) summer session of 1992 to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed.

Space Science Curricula

NASA Technical Reports Server (NTRS)

1990-01-01

Johnson High School, Huntsville, Alabama started an international magnet program in 1987. One of the courses in the curriculum was in space science. They appealed to Marshall Space Flight Center (MSFC) when they couldn't find a suitable textbook, nor locate other classes in space science to provide a guideline. MSFC agreed to help and placed the school under an official 'Adopt-A-School' program. MSFC's chief scientist and others at the space center helped prepare a very comprehensive space science program. Examples of the subjects covered include problems of space travel, materials processing in space, technology utilization, robotics, space colonization, etc. MSFC followed up by working with Johnson High to determine if the curriculum is generally usable and workable. If it is, MSFC may make it available to other schools. MSFC not only developed the space science curriculum; they continue to support the program by sponsoring hands- on activities and tours of space research facilities.

Photo and Thermal Behavior of New Reinforced Polyamide-nanocomposite Montmorillonite on 2,3-Pyrazin Dicarboxylic Acid

NASA Astrophysics Data System (ADS)

Faghihi, Khalil; Samiei, Mojtaba; Hajibeygi, Mohsen

2012-06-01

Two new samples of reinforce polyamidemontmorillonite nanocomposites were synthesized by a convenient solution intercalation technique. Polyamide (PA) 3 as a source of polymer matrix was synthesized by the direct polycondensation reaction of pyrazine 2,3-dicarboxylic acid 1 with 4,4'-diamino diphenyl ether 2 in the presence of triphenyl phosphite (TPP), CaCl2, pyridine and N-methyl-2-pyrrolidone (NMP). The resulting nanocomposite films were characterized by Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The results showed that organo-modified clay was dispersed homogeneously in PA matrix. TGA indicated an enhancement of thermal stability of new nanocomposites compared with the pure polymer.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Space station program phase B definition: Nuclear reactor-powered space station cost and schedules

NASA Technical Reports Server (NTRS)

1971-01-01

Tabulated data are presented on the costs, schedules, and technical characteristics for the space station phases C and D program. The work breakdown structure, schedule data, program ground rules, program costs, cost-estimating rationale, funding schedules, and supporting data are included.

KENNEDY SPACE CENTER, FLA. - Lisa Malone, deputy director of External Relations and Business Development at KSC, emcees a ceremony in the Space Station Processing Facility to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Speakers at the ceremony included KSC Director Roy Bridges Jr.; NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Lisa Malone, deputy director of External Relations and Business Development at KSC, emcees a ceremony in the Space Station Processing Facility to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Speakers at the ceremony included KSC Director Roy Bridges Jr.; NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA); and NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, sign documents officially transferring ownership of Node 2 between the ESA and NASA. The signing was part of a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module (above right) of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA); and NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, sign documents officially transferring ownership of Node 2 between the ESA and NASA. The signing was part of a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module (above right) of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

Joint Space Operations Center (JSpOC) Mission System Increment 3 (JMS Inc 3)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Joint Space Operations Center (JSpOC) Mission System Increment 3 (JMS Inc 3) Defense...1725 DSN Phone: DSN Fax: Date Assigned: May 16, 2014 Program Information Program Name Joint Space Operations Center (JSpOC) Mission System...approved program baseline; therefore, no Original Estimate has been established. JMS Inc 3 2016 MAR UNCLASSIFIED 4 Program Description The Joint Space

Economic effects and spin-offs in a small space economy: the case of Canada.

PubMed

Amesse, Fernand; Cohendet, Patrick; Poirier, Alain; Chouinard, Jean-Marc

2002-12-01

Canada, through a well-focused space program (telecommunications, earth observation, robotics), has succeeded in developing a space industry largely based on SMEs. The result has been significant economic benefits and technological spin-offs. In this article, the results of two programs, the ESA (European Space Agency) and the STEAR (Strategic Technologies in Automation and Robotics), are compared. The ESA program has generated significant indirect effects and spin-offs for Canadian exports. ESA's reputation and network have enabled SMEs to increase export sales of both space products and other commercial products derived from space technologies. The STEAR program has been highly successful in promoting a new generation of SMEs for space robotics, encouraging both spin-in and spin-offs of technologies. The analysis highlights the complementarity of mission- and diffusion-oriented programs in the technology transfer process.

OpportunitiesandPerceptionofSpaceProgramsintheDevelopingCountries

NASA Astrophysics Data System (ADS)

Abubakar, B.

2007-05-01

Although the space program as a whole is a true reflection of the level of achievement in human history in the field of Science and Technology, but it is also important to note that there are numbers of communities and societies on this earth that are ignorant about this great achievement, hence leading to the continuous diverting of Potential Astronomers, Aerospace Engineers and Astrologist to other disciplines, thereby undermining the development of the space program over time. It was in view of the above that this research was conducted and came up with the under listed Suggestions/Recommendations:- (1) The European Space Agency (ESA), National Aeronautic Space Agency (NASA) and the Russian Space Agency, should be organising and sponsoring public enlightenment conferences, seminars and workshops towards creating awareness and attracting Potential Astronomers and other Space Scientist mostly in the developing countries into the space program. (2) Esteemed organisations in space programs like NASA, ESA and others should be awarding scholarships to potential space scientist that lacks the financial capability to pursue studies in the field of space science from the developing countries. (3) The European Space Agency, National Aeronautic Space Agency and the Russian Space Agency, should open their offices for the development of the space program in the third world countries. I believe that if the above suggestions/recommendations are adopted and implemented it will lead to the development of the space program in general, otherwise the rate at which potential Astronomers, Aerospace Engineers and Astrologists will be diverting into other disciplines will ever remain on the increase. Thanks for listening.

Manned Systems Utilization Analysis. Study 2.1: Space Servicing Pilot Program Study. [for automated payloads

NASA Technical Reports Server (NTRS)

Wolfe, R. R.

1975-01-01

Space servicing automated payloads was studied for potential cost benefits for future payload operations. Background information is provided on space servicing in general, and on a pilot flight test program in particular. An fight test is recommended to demonstrate space servicing. An overall program plan is provided which builds upon the pilot program through an interim servicing capability. A multipayload servicing concept for the time when the full capability tug becomes operational is presented. The space test program is specifically designed to provide low-cost booster vehicles and a flight test platform for several experiments on a single flight.

Space Radiation Program Element

NASA Technical Reports Server (NTRS)

Krenek, Sam

2008-01-01

This poster presentation shows the various elements of the Space Radiation Program. It reviews the program requirements: develop and validate standards, quantify space radiation human health risks, mitigate risks through countermeasures and technologies, and treat and monitor unmitigated risks.

KENNEDY SPACE CENTER, FLA. - Hundreds of guests attend a ribbon cutting ceremony officially opening the U.S. Astronaut Hall of Fame as part of the Kennedy Space Center Visitor Complex. The ceremony was held in conjunction with the induction of four Space Shuttle astronauts into the Hall of Fame including Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

NASA Image and Video Library

2003-06-20

KENNEDY SPACE CENTER, FLA. - Hundreds of guests attend a ribbon cutting ceremony officially opening the U.S. Astronaut Hall of Fame as part of the Kennedy Space Center Visitor Complex. The ceremony was held in conjunction with the induction of four Space Shuttle astronauts into the Hall of Fame including Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

Review of the Space Applications program, 1974

NASA Technical Reports Server (NTRS)

1974-01-01

The purpose of this review is to provide the participants in the National Aeronautics and Space Administration/National Academy of Engineers' Summer Study in Applications a concise overview of the NASA Applications Program as it stands in 1974. The review covers the accomplishments of the various discipline-oriented programs that make up the total Applications Program, discusses the program plan for the 1975 to 1980 period, and examines the anticipated spaceflight capabilities of the 1980's. NASA has requested the National Academy of Engineers to conduct through its Space Applications Board a comprehensive study of the future Space Applications Program encompassing the following: (1) the Applications Program in general, with particular emphasis on practical approaches, including assessment of the socio-economic benefits and (2) how the broad comprehensive program envisioned above influences, or is influenced by, the shuttle system, the principal space transport system of the 1980's.

NASA wiring for space applications program

NASA Technical Reports Server (NTRS)

Schulze, Norman

1995-01-01

An overview of the NASA Wiring for Space Applications Program and its relationship to NASA's space technology enterprise is given in viewgraph format. The mission of the space technology enterprise is to pioneer, with industry, the development and use of space technology to secure national economic competitiveness, promote industrial growth, and to support space missions. The objectives of the NASA Wiring for Space Applications Program is to improve the safety, performance, and reliability of wiring systems for space applications and to develop improved wiring technologies for NASA flight programs and commercial applications. Wiring system failures in space and commercial applications have shown the need for arc track resistant wiring constructions. A matrix of tests performed versus wiring constructions is presented. Preliminary data indicate the performance of the Tensolite and Filotex hybrid constructions are the best of the various candidates.

National Space Club

NASA Image and Video Library

2018-03-20

NASA Kennedy Space Center Director Bob Cabana speaks to National Space Club-Florida Chapter (NSCFC) members and guests at the Radisson Resort at the Port in Cape Canaveral, Florida. Cabana's presentation was titled, "KSC - Space Exploration Begins Here." He included an update on the multi-user spaceport and several programs, including Exploration Ground Systems, Launch Services Program and Commercial Crew Program. The NSCFC is a non-profit organization composed of representatives from the space industry, government, educational institutions, and private individuals who share a commitment to increasing public awareness of America's aerospace programs.

Students at the Edge of Space

ERIC Educational Resources Information Center

Kennon, Tillman; Roberts, Ed; Fuller, Teresa

2008-01-01

Space travel, even low Earth orbit, is probably several years away for most of us; however, students and teachers can research the edge of space by participating in the BalloonSat program. BalloonSat is an offshoot of the Space Grant Consortium's very successful RocketSat program. The Arkansas BalloonSat program consists of teacher-initiated…

In-space production of large space systems from extraterrestrial materials: A program implementation model

NASA Technical Reports Server (NTRS)

Vontiesenhausen, G. F.

1977-01-01

A program implementation model is presented which covers the in-space construction of certain large space systems from extraterrestrial materials. The model includes descriptions of major program elements and subelements and their operational requirements and technology readiness requirements. It provides a structure for future analysis and development.

Preparation and Characterization of Polyimide/Organoclay Nanocomposites

NASA Technical Reports Server (NTRS)

Delozier, D. M.; Orwoll, R. A.; Cahoon, J. F.; Johnston, N. J.; Smith, J. G., Jr.; Connell, J. W.

2002-01-01

Organically modified montmorrrillonite clay, containing a long chain aliphatic quarternary ammonium cation, was used to prepare polyimide/organoclay hybrids. Several approaches were examined in an attempt to achieve fully exfoliated nanocomposites. These included simple mixing of the clay in a pre-made high molecular weight poly(amide acid) solution; simple mixing followed by sonication of the organoclay/poly(amide acid) solutions; and the preparation of high molecular weight poly(amide acid)s in the presence of the organoclay dispersed in N-methyl-2-pyrrolidinone (NMP). The best results were obtained using the in-situ polymerization approach. The resulting nanocomposite films (both amide acid and imide), containing 3-8% by weight of organoclay, were characterized by differential scanning calorimetry (DSC), dynamic thermogravimetric analysis (TGA), transmission electron microscopy (TEM), X-ray diffraction (XRD), and thin film tensile properties. A significant degree of dispersion was observed in the nanocomposite films of the amide acid and the imide. After thermal treatment of amide acid films to effect imidization, in both air and nitrogen, the films were visually darker than control films without clay and the level of clay dispersion appeared to have decreased. In the latter case, the separation between the layers of the clay decreased to a spacing less than that present in the original organoclay. These observations suggest that thermal degradation of the aliphatic quarternary ammonium cation occurred likely during thermal treatment to effect imidization and solvent removal. These thermal degradation effects were less pronounced when thermal treatment was performed under nitrogen. The polyimide/organoclay hybrid films exhibited higher room temperature tensile moduli and lower strength and elongation to break than the control films.

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle (center), International Space Station Program manager for Node 2, European Space Agency (ESA); and NASA’s Michael C. Kostelnik (right), deputy associate administrator for International Space Station and Shuttle Programs, sign documents officially transferring ownership of Node 2 between the ESA and NASA. At left, also part of the signing, is Andrea Lorenzoni (left), International Space Station Program manager for Node 2, Italian Space Agency. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle (center), International Space Station Program manager for Node 2, European Space Agency (ESA); and NASA’s Michael C. Kostelnik (right), deputy associate administrator for International Space Station and Shuttle Programs, sign documents officially transferring ownership of Node 2 between the ESA and NASA. At left, also part of the signing, is Andrea Lorenzoni (left), International Space Station Program manager for Node 2, Italian Space Agency. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Selected Technical Spin Offs from the Space Program

NASA Technical Reports Server (NTRS)

Gilmore, H. L.

1970-01-01

The report describes some of the problems which the National Aeronautics and Space Administration has encountered in getting people to understand how the general public has profited from the technical discoveries of the space program. Next, it describes NASA's Technology Utilization Program and comments on it. It then describes some of the many spin-offs from the space program. These include examples from management technology, communications, aeronautics, medicine, fabrics highway safety, and weather forecasting.

Forward Skirt Structural Testing on the Space Launch System (SLS) Program

NASA Technical Reports Server (NTRS)

Lohrer, J. D.; Wright, R. D.

2016-01-01

Structural testing was performed to evaluate heritage forward skirts from the Space Shuttle program for use on the NASA Space Launch System (SLS) program. Testing was needed because SLS ascent loads are 35% higher than Space Shuttle loads. Objectives of testing were to determine margins of safety, demonstrate reliability, and validate analytical models. Testing combined with analysis was able to show heritage forward skirts were acceptable to use on the SLS program.

Early Program Development

NASA Image and Video Library

1969-01-01

This 1969 artist's concept illustrates the use of three major elements of NASA's Integrated program, as proposed by President Nixon's Space Task Group. In Phases I and II, a Space Tug with a manipulator-equipped crew module removes a cargo module from an early Space Shuttle Orbiter and docks with it. In Phases III and IV, the Space Tug with attached cargo module flys toward a Nuclear Shuttle. As a result of the Space Task Group's recommendations for more commonality and integration in the American space program, Marshall Space Flight Center engineers studied many of the spacecraft depicted here.

Explorations in Education and Public Outreach in Space Sciences - a Wisconsin Experience

NASA Astrophysics Data System (ADS)

Limaye, S. S.; Pertzborn, R. A.

1999-09-01

To better serve the Education and Public Outreach needs of federally funded space science research programs at the University of Wisconsin, an Office of Space Science Education has recently been established on the University of Wisconsin-Madison campus. This office also acts as the campus focus for the Wisconsin Space Grant Consortium, and has undertaken a broad spectrum of interdisciplinary space science programs in the past several years. These activities range from a public exhibition focusing on current space exploration in conjunction with the DPS '98 meeting in Madison, WI that attracted over 5,000 students and teachers from across the state, to organizing state-of-the-art HDTV presentations on earth remote sensing topics at a Milwaukee science museum. Programs for students have included development and support of a six week solar system exploration program in the Milwaukee Public Schools for at-risk students, a two week college access program for minority middle school students, the NASA/QEM/SHARP Plus program for minority high school students, and a web based journal for middle school science projects (SPARK). Teacher professional development efforts include summer workshops for academic credit, year-round classroom support for pilot school programs, and support for development of standards-based curriculum in both space science and earth remote sensing topics. Public outreach activities have included evening family activities and public lectures at the Space Place, an off-campus outreach center, and an ask-a-scientist web based program. These efforts continue to affirm the need for effective outreach programs for diverse and multigenerational communities. In spite of the growing recognition at both the state and federal level for an improved level of literacy in the space-related sciences, sustainable support, program opportunities and logistical implementation continue to pose significant challenges. We gratefully acknowledge the support we have received from NASA, NOAA, the Division for Planetary Sciences of the AAS (space exploration exhibition), the University of Wisconsin System and the Eisenhower Professional Development Program.

The Indian Space Program

NASA Technical Reports Server (NTRS)

Talapatra, Dipak C.

1993-01-01

The Indian Space program aimed at providing operation space services in communications and remote sensing and using state-of-the-art space technologies is reviewed. Emphasis is placed on the development and operation of satellites and launch vehicles for providing these space services.

75 FR 23841 - Commercial Space Transportation Grant Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Grant... for the Commercial Space Transportation Grant Program. SUMMARY: The FAA's Office of Commercial Space Transportation (AST) requests grant proposals pursuant to its newly funded Commercial Space Transportation Grant...

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA), speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA), speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - At the KSC Visitor Complex, former astronaut James Lovell makes the opening remarks at the induction ceremony of four Space Shuttle astronauts into the U.S. Astronaut Hall of Fame. Being inducted are Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

NASA Image and Video Library

2003-06-21

KENNEDY SPACE CENTER, FLA. - At the KSC Visitor Complex, former astronaut James Lovell makes the opening remarks at the induction ceremony of four Space Shuttle astronauts into the U.S. Astronaut Hall of Fame. Being inducted are Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

NASA's new university engineering space research programs

NASA Technical Reports Server (NTRS)

Sadin, Stanley R.

1988-01-01

The objective of a newly emerging element of NASA's university engineering programs is to provide a more autonomous element that will enhance and broaden the capabilities in academia, enabling them to participate more effectively in the U.S. civil space program. The programs utilize technical monitors at NASA centers to foster collaborative arrangements, exchange of personnel, and the sharing of facilities between NASA and the universities. The elements include: the university advanced space design program, which funds advanced systems study courses at the senior and graduate levels; the university space engineering research program that supports cross-disciplinary research centers; the outreach flight experiments program that offers engineering research opportunities to universities; and the planned university investigator's research program to provide grants to individuals with outstanding credentials.

NASA's commercial space program - Initiatives for the future

NASA Technical Reports Server (NTRS)

Rose, James T.; Stone, Barbara A.

1990-01-01

NASA's commercial development of the space program aimed at the stimulation and assistance of expanded private sector involvement and investment in civil space activities is discussed, focusing on major new program initiatives and their implementation. NASA's Centers for the Commercial Development of Space (CCDS) program, composed of competitively selected consortia of universities, industries, and government involved in early research and testing phases of potentially commercially viable technologies is described. The 16 centers concentrate on seven different technical areas such as automation and robotics; remote sensing; life sciences; and space power, propulsion, and structures. Private sector participation, CCDS technology development, government and commercially supplied access to space in support of CCDS programs, CCDS hardware development, and CCDS spinoffs are discussed together with various cooperative and reimbursable agreements between NASA and the private sector.

U.S. commercial space activities - Returning the U.S. to preeminence in space

NASA Technical Reports Server (NTRS)

Stone, Barbara A.

1987-01-01

The current status of NASA's activities related to the commercial development of space is reviewed with particular reference to the emerging new commercial space activities and the post-Challenger policy developments affecting space commerce. The discussion covers the development of U.S. private sector launching capabilities, cooperative agreements with the private sector, the NASA technology utilization program, the technology applications activities of the Office of Commercial Programs, and the activities of the Centers for the Commercial Development of Space program.

Microgravity research results and experiences from the NASA/MIR space station program.

PubMed

Schlagheck, R A; Trach, B L

2003-12-01

The Microgravity Research Program (MRP) participated aggressively in Phase 1 of the International Space Station Program using the Russian Mir Space Station. The Mir Station offered an otherwise unavailable opportunity to explore the advantages and challenges of long duration microgravity space research. Payloads with both National Aeronautics and Space Agency (NASA) and commercial backing were included as well as cooperative research with the Canadian Space Agency (CSA). From this experience, much was learned about long-duration on-orbit science utilization and developing new working relationships with our Russian partner to promote efficient planning, operations, and integration to solve complexities associated with a multiple partner program. This paper focuses on the microgravity research conducted onboard the Mir space station. It includes the Program preparation and planning necessary to support this type of cross increment research experience; the payloads which were flown; and summaries of significant microgravity science findings. Published by Elsevier Ltd.

Space technology research plans

NASA Technical Reports Server (NTRS)

Hook, W. Ray

1992-01-01

Development of new technologies is the primary purpose of the Office of Aeronautics and Space Technology (OAST). OAST's mission includes the following two goals: (1) to conduct research to provide fundamental understanding, develop advanced technology and promote technology transfer to assure U.S. preeminence in aeronautics and to enhance and/or enable future civil space missions: and (2) to provide unique facilities and technical expertise to support national aerospace needs. OAST includes both NASA Headquarters operations as well as programmatic and institutional management of the Ames Research Center, the Langley Research Center and the Lewis Research Center. In addition. a considerable portion of OAST's Space R&T Program is conducted through the flight and science program field centers of NASA. Within OAST, the Space Technology Directorate is responsible for the planning and implementation of the NASA Space Research and Technology Program. The Space Technology Directorate's mission is 'to assure that OAST shall provide technology for future civil space missions and provide a base of research and technology capabilities to serve all national space goals.' Accomplishing this mission entails the following objectives: y Identify, develop, validate and transfer technology to: (1) increase mission safety and reliability; (2) reduce flight program development and operations costs; (3) enhance mission performance; and (4) enable new missions. Provide the capability to: (1) advance technology in critical disciplines; and (2) respond to unanticipated mission needs. In-space experiments are an integral part of OAST's program and provides for experimental studies, development and support for in-space flight research and validation of advanced space technologies. Conducting technology experiments in space is a valuable and cost effective way to introduce advanced technologies into flight programs. These flight experiments support both the R&T base and the focussed programs within OAST.

Space activity and programs at SOFRADIR

NASA Astrophysics Data System (ADS)

Bouakka-Manesse, A.; Jamin, N.; Delannoy, A.; Fieque, B.; Leroy, C.; Pidancier, P.; Vial, L.; Chorier, P.; Péré-Laperne, N.

2016-09-01

SOFRADIR is one of the leading companies involved in the development and manufacturing of infrared detectors for space applications. As a matter of fact, SOFRADIR is involved in many space programs from visible up to VLWIR spectral ranges. These programs concern operational missions for earth imagery, meteorology and also scientific missions for universe exploration. One of the last space detectors available at SOFRADIR is a visible - SWIR detector named Next Generation Panchromatic Detector (NGP) which is well adapted for hyperspectral, imagery and spectroscopy applications. In parallel of this new space detector, numerous programs are currently running for different kind of missions: meteorology (MTG), Copernicus with the Sentinel detectors series, Metop-SG system (3MI), Mars exploration (Mamiss, etc.). In this paper, we present the last developments made for space activity and in particular the NGP detector. We will also present the space applications using this detector and show appropriateness of its use to answer space programs specifications, as for example those of Sentinel-5.

Space activity and programs at Sofradir

NASA Astrophysics Data System (ADS)

Bouakka-Manesse, A.; Jamin, N.; Delannoy, A.; Fièque, B.; Leroy, C.; Pidancier, P.; Vial, L.; Chorier, P.; Péré Laperne, N.

2016-10-01

SOFRADIR is one of the leading companies involved in the development and manufacturing of infrared detectors for space applications. As a matter of fact, SOFRADIR is involved in many space programs from visible up to VLWIR spectral ranges. These programs concern operational missions for earth imagery, meteorology and also scientific missions for universe exploration. One of the last space detectors available at SOFRADIR is a visible - SWIR detector named Next Generation Panchromatic Detector (NGP) which is well adapted for hyperspectral, imagery and spectroscopy applications. In parallel of this new space detector, numerous programs are currently running for different kind of missions: meteorology (MTG), Copernicus with the Sentinel detectors series, Metop-SG system (3MI), Mars exploration (Mamiss, etc….)… In this paper, we present the last developments made for space activity and in particular the NGP detector. We will also present the space applications using this detector and show appropriateness of its use to answer space programs specifications, as for example those of Sentinel-5.

NASA's Space Environments and Effects (SEE) Program: Contamination Engineering Technology Development

NASA Technical Reports Server (NTRS)

Pearson, Steven D.; Clifton, K. Stuart

1999-01-01

ABSTRACT The return of the Long Duration Exposure Facility (LDEF) in 1990 brought a wealth of space exposure data on materials, paints, solar cells, etc. and data on the many space environments. The effects of the harsh space environments can provide damaging or even disabling effects on spacecraft, its materials, and its instruments. In partnership with industry, academia, and other government agencies, National Aeronautics & Space Administration's (NASA's) Space Environments & Effects (SEE) Program defines the space environments and provides technology development to accommodate or mitigate these harmful environments on the spacecraft. This program provides a very comprehensive and focused approach to understanding the space environment, to define the best techniques for both flight and ground-based experimentation, to update the models which predict both the environments and the environmental effects on spacecraft, and finally to ensure that this information is properly maintained and inserted into spacecraft design programs. This paper will describe the current SEE Program and will present SEE contamination engineering technology development and risk mitigation for future spacecraft design.

NASA's Space Environments and Effects (SEE) program: contamination engineering technology development

NASA Astrophysics Data System (ADS)

Pearson, Steven D.; Clifton, K. Stuart

1999-10-01

The return of the Long Duration Exposure Facility (LDEF) in 1990 brought a wealth of space exposure data on materials, paints, solar cells, etc. and data on the many space environments. The effects of the harsh space environments can provide damaging or even disabling effects on spacecraft, its materials, and its instruments. In partnership with industry, academia, and other government agencies, National Aeronautics & Space Administration's (NASA's) Space Environments & Effects (SEE) Program defines the space environments and provides technology development to accommodate or mitigate these harmful environments on the spacecraft. This program provides a very comprehensive and focused approach to understanding the space environment, to define the best techniques for both flight and ground-based experimentation, to update the models which predict both the environments and the environmental effects on spacecraft, and finally to ensure that this information is properly maintained and inserted into spacecraft design programs. This paper will describe the current SEE Program and will present SEE contamination engineering technology development and risk mitigation for future spacecraft design.

Space Shuttle Projects Overview to Columbia Air Forces War College

NASA Technical Reports Server (NTRS)

Singer, Jody; McCool, Alex (Technical Monitor)

2000-01-01

This paper presents, in viewgraph form, a general overview of space shuttle projects. Some of the topics include: 1) Space Shuttle Projects; 2) Marshall Space Flight Center Space Shuttle Projects Office; 3) Space Shuttle Propulsion systems; 4) Space Shuttle Program Major Sites; 5) NASA Office of Space flight (OSF) Center Roles in Space Shuttle Program; 6) Space Shuttle Hardware Flow; and 7) Shuttle Flights To Date.

Using NASA and the Space Program to Help High School and College Students Learn Chemistry.

ERIC Educational Resources Information Center

Kelter, Paul B.; And Others

1987-01-01

Discusses some of the chemical concepts that the United States Space Program illustrates. Describes ways to use the space program to motivate students to learn chemistry and its relationship to the world. Provides examples of classroom applications to environmental chemistry and biochemistry in studying the operation of the space shuttle. (TW)

Beyond the atmosphere: Early years of space science

NASA Technical Reports Server (NTRS)

Newell, H. E.

1980-01-01

From the rocket measurements of the upper atmosphere and Sun that began in 1946, space science gradually emerged as a new field of scientific activity. The course of the United State space program is viewed in an historical context. Major emphasis is on NASA and its programs. The funding, staffing, organization, and priorities of the space program were reviewed.

Toward a space materials systems program

NASA Technical Reports Server (NTRS)

Vontiesenhausen, G. F.

1981-01-01

A program implementation model is presented which covers the early stages of space material processing and manufacturing. The model includes descriptions of major program elements, development and experiment requirements in space materials processing and manufacturing, and an integration of the model into NASA's long range plans as well as its evolution from present Materials Processing in Space plans.

KSC All Hands

NASA Image and Video Library

2018-01-11

Lisa Colloredo, deputy program manager for the Commercial Crew Program, speaks to Kennedy Space Center employees about plans for the coming year. The event took place in the Lunar Theater at the Kennedy Space Center Visitor Complex’s Apollo Saturn V Center. The year will be highlighted with NASA's partners preparing test flights for crewed missions to the International Space Station as part of the agency's Commercial Crew Program and six launches by the Launch Services Program. Exploration Ground Systems will be completing facilities to support the Space Launch System rocket and Orion spacecraft. Exploration Research and Technology Programs will continue to provide supplies to the space station launched as part of the Commercial Resupply Services effort.

Space prospects. [european space programs

NASA Technical Reports Server (NTRS)

1980-01-01

A strategy for keeping the Common Market's space effort independent of and competitive with NASA and the space shuttle is discussed. Limited financing is the chief obstacle to this. Proposals include an outer space materials processing project and further development of the Ariane rocket. A manned space program is excluded for the foreseeable future.

European space programme

NASA Astrophysics Data System (ADS)

Luton, J.-M.

1992-02-01

Successful European Space Agency (ESA) programs include the Ariane launcher development, the Meteosat meteorological satellites and the Intelsat 6, ECS (European Communications Satellite) series of communications satellites. The ESA's policy of placing contracts with industrial companies in its 13 member countries has contributed to the strategic development of European high technology in the world market. The ESA's long-term programs, in addition to the Ariane launcher and Columbus/Hermes space-station/spaceplane programs, include participation in the International Space Station program, the Data Relay Satellite system and a variety of space applications programs. Two high-performance satellites to be placed in polar orbits will contribute to European environmental and climate variation studies and, together with the Polar Platform sector of the Columbus program, will drive the establishment and development of new institutions, industrial structures and infrastructure.

Space America's commercial space program

NASA Technical Reports Server (NTRS)

Macleod, N. H.

1984-01-01

Space America prepared a private sector land observing space system which includes a sensor system with eight spectral channels configured for stereoscopic data acquisition of four stereo pairs, a spacecraft bus with active three-axis stabilization, a ground station for data acquisition, preprocessing and retransmission. The land observing system is a component of Space America's end-to-end system for Earth resources management, monitoring and exploration. In the context of the Federal Government's program of commercialization of the US land remote sensing program, Space America's space system is characteristic of US industry's use of advanced technology and of commercial, entrepreneurial management. Well before the issuance of the Request for Proposals for Transfer of the United States Land Remote Sensing Program to the Private Sector by the US Department of Commerce, Space Services, Inc., the managing venturer of Space America, used private funds to develop and manage its sub-orbital launch of its Conestoga launch vehicle.

Space Station Engineering and Technology Development. Proceedings of the Panel on Program Performance and Onboard Mission Control

NASA Technical Reports Server (NTRS)

1985-01-01

An ad-hoc committee was asked to review the following questions relevant to the space station program: (1) onboard maintainability and repair; (2) in-space research and technology program and facility plans; (3) solar thermodynamic research and technology development program planning; (4) program performance (cost estimating, management, and cost avoidance); (5) onboard versus ground-based mission control; and (6) technology development road maps from IOC to the growth station. The objective of these new assignments is to provide NASA with advice on ways and means for improving the content, performance, and/or effectiveness of these elements of the space station program.

Validation of an immersive virtual reality system for training near and far space neglect in individuals with stroke: a pilot study.

PubMed

Yasuda, Kazuhiro; Muroi, Daisuke; Ohira, Masahiro; Iwata, Hiroyasu

2017-10-01

Unilateral spatial neglect (USN) is defined as impaired ability to attend and see on one side, and when present, it interferes seriously with daily life. These symptoms can exist for near and far spaces combined or independently, and it is important to provide effective intervention for near and far space neglect. The purpose of this pilot study was to propose an immersive virtual reality (VR) rehabilitation program using a head-mounted display that is able to train both near and far space neglect, and to validate the immediate effect of the VR program in both near and far space neglect. Ten USN patients underwent the VR program with a pre-post design and no control. In the virtual environment, we developed visual searching and reaching tasks using an immersive VR system. Behavioral inattention test (BIT) scores obtained pre- and immediate post-VR program were compared. BIT scores obtained pre- and post-VR program revealed that far space neglect but not near space neglect improved promptly after the VR program. This effect for far space neglect was observed in the cancelation task, but not in the line bisection task. Positive effects of the immersive VR program for far space neglect are suggested by the results of the present pilot study. However, further studies with rigorous designs are needed to validate its clinical effectiveness.

NASA's Space Life Sciences Training Program.

PubMed

Coulter, G; Lewis, L; Atchison, D

1994-01-01

The Space Life Sciences Training Program (SLSTP) is an intensive, six-week training program held every summer since 1985 at the Kennedy Space Center (KSC). A major goal of the SLSTP is to develop a cadre of qualified scientists and engineers to support future space life sciences and engineering challenges. Hand-picked, undergraduate college students participate in lectures, laboratory sessions, facility tours, and special projects: including work on actual Space Shuttle flight experiments and baseline data collection. At NASA Headquarters (HQ), the SLSTP is jointly sponsored by the Life Sciences Division and the Office of Equal Opportunity Programs: it has been very successful in attracting minority students and women to the fields of space science and engineering. In honor of the International Space Year (ISY), 17 international students participated in this summer's program. An SLSTP Symposium was held in Washington D.C., just prior to the World Space Congress. The Symposium attracted over 150 SLSTP graduates for a day of scientific discussions and briefings concerning educational and employment opportunities within NASA and the aerospace community. Future plans for the SLSTP include expansion to the Johnson Space Center in 1995.

NASA's Space Life Sciences Training Program

NASA Technical Reports Server (NTRS)

Coulter, G.; Lewis, L.; Atchison, D.

1994-01-01

The Space Life Sciences Training Program (SLSTP) is an intensive, six-week training program held every summer since 1985 at the Kennedy Space Center (KSC). A major goal of the SLSTP is to develop a cadre of qualified scientists and engineers to support future space life sciences and engineering challenges. Hand-picked, undergraduate college students participate in lectures, laboratory sessions, facility tours, and special projects: including work on actual Space Shuttle flight experiments and baseline data collection. At NASA Headquarters (HQ), the SLSTP is jointly sponsored by the Life Sciences Division and the Office of Equal Opportunity Programs: it has been very successful in attracting minority students and women to the fields of space science and engineering. In honor of the International Space Year (ISY), 17 international students participated in this summer's program. An SLSTP Symposium was held in Washington D. C., just prior to the World Space Congress. The Symposium attracted over 150 SLSTP graduates for a day of scientific discussions and briefings concerning educational and employment opportunities within NASA and the aerospace community. Future plans for the SLSTP include expansion to the Johnson Space Center in 1995.

NASA's Space Environments and Effects (SEE) Program

NASA Technical Reports Server (NTRS)

Minor, Jody

2001-01-01

The return of the Long Duration Exposure Facility (LDEF) in 1990 brought a wealth of space exposure data on materials, paints, solar cells, adhesives and other data on the many space environments. The effects of the harsh space environments can provide damaging or even disabling effects on a spacecraft, its sub-systems, materials and instruments. In partnership with industry, academia, and other US and international government agencies, the National Aeronautics & Space Administration's (NASA's) Space Environments & Effects (SEE) Program defines the space environments and provides technology development to accommodate or mitigate these harmful environments on the spacecraft. This program (agency-wide in scope but managed at the Marshall Space Flight Center) provides a very comprehensive and focused approach to understanding the space environment. It does this by defining the best techniques for both flight- and groundbased experimentation, updating models which predict both the environments and the environmental effects on spacecraft and ensuring that this information is properly maintained and inserted into spacecraft design programs. This paper will describe the current SEE Program and discuss several current technology development activities associated with the spacecraft charging phenomenon.

Chronology: MSFC Space Shuttle program development, assembly, and testing major events (1969 - April, 1981)

NASA Technical Reports Server (NTRS)

Whalen, Jessie E. (Compiler); Mckinley, Sarah L. (Compiler); Gates, Thomas G. (Compiler)

1988-01-01

Listings of major events directly related to the Space Shuttle Program at Marshall Space Flight Center (MSFC) are presented. This information will provide the researcher with a means of following the chronological progression of the program. The products that the historians have prepared are intended to provide supportive research essential to the writing of formal narrative histories of Marshall's contributions to the Space Shuttle and Space Station.

KSC-03PD-3248

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Space Solar Power Program. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arif, Humayun; Barbosa, Hugo; Bardet, Christophe

1992-08-01

Information pertaining to the Space Solar Power Program is presented on energy analysis; markets; overall development plan; organizational plan; environmental and safety issues; power systems; space transportation; space manufacturing, construction, operations; design examples; and finance.

KENNEDY SPACE CENTER, FLA. -- A United Space Alliance (USA) technician (center) discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- A United Space Alliance (USA) technician (center) discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. - Former astronaut James Lovell addresses the audience at a ribbon cutting ceremony officially opening the U.S. Astronaut Hall of Fame as part of the Kennedy Space Center Visitor Complex. The ceremony was held in conjunction with the induction of four Space Shuttle astronauts into the Hall of Fame including Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

NASA Image and Video Library

2003-06-20

KENNEDY SPACE CENTER, FLA. - Former astronaut James Lovell addresses the audience at a ribbon cutting ceremony officially opening the U.S. Astronaut Hall of Fame as part of the Kennedy Space Center Visitor Complex. The ceremony was held in conjunction with the induction of four Space Shuttle astronauts into the Hall of Fame including Daniel Brandenstein, Robert "Hoot" Gibson, Story Musgrave, and Sally Ride. Conceived by six of the Mercury Program astronauts, the U.S. Astronaut Hall of Fame opened in 1990 to provide a place where space travelers could be remembered for their participation and accomplishments in the U.S. space program. The four new inductees join 48 previously honored astronauts from the ranks of the Gemini, Apollo, Skylab, Apollo-Soyuz, and Space Shuttle programs.

The use of continuing adult education

NASA Technical Reports Server (NTRS)

Redd, Frank J.

1990-01-01

The objectives of the National Space Grant and Fellowship Program include the expansion of space-oriented educational programs beyond the traditional boundaries of university campuses to reach 'non-traditional' students whose personal and professional lives would be enhanced by access to such programs. These objectives coincide with those of the continuing education programs that exist on most university campuses. By utilizing continuing educations resources and facilities, members of the National Space Grant Program can greatly enhance the achievement of program objectives.

Space Shuttle wind tunnel testing program

NASA Technical Reports Server (NTRS)

Whitnah, A. M.; Hillje, E. R.

1984-01-01

A major phase of the Space Shuttle Vehicle (SSV) Development Program was the acquisition of data through the space shuttle wind tunnel testing program. It became obvious that the large number of configuration/environment combinations would necessitate an extremely large wind tunnel testing program. To make the most efficient use of available test facilities and to assist the prime contractor for orbiter design and space shuttle vehicle integration, a unique management plan was devised for the design and development phase. The space shuttle program is reviewed together with the evolutional development of the shuttle configuration. The wind tunnel testing rationale and the associated test program management plan and its overall results is reviewed. Information is given for the various facilities and models used within this program. A unique posttest documentation procedure and a summary of the types of test per disciplines, per facility, and per model are presented with detailed listing of the posttest documentation.

International programs

NASA Technical Reports Server (NTRS)

1973-01-01

Brief summaries are given of NASA's participation in international space programs. This participation can be categorized in five principal areas: manned space flight, space sciences, space applications, ground support of space operations, and cooperative international aeronautics research. All projects are carried out on a cooperative or reimbursable basis.

Chronology: MSFC Space Station program, 1982 - present. Major events

NASA Technical Reports Server (NTRS)

Whalen, Jessie E. (Compiler); Mckinley, Sarah L. (Compiler); Gates, Thomas G. (Compiler)

1988-01-01

The Marshall Space Flight Center (MSFC) maintains an active program to capture historical information and documentation on the MSFC's roles regarding Space Shuttle and Space Station. Marshall History Report 12, called Chronology: MSFC Space Station Program, 1982-Present, is presented. It contains synopses of major events listed according to the dates of their occurrence. Indices follow the synopses and provide additional data concerning the events listed. The Event Index provides a brief listing of all the events without synopses. The Element Index lists the specific elements of the Space Station Program under consideration in the events. The Location Index lists the locations where the events took place. The indices and synopses may be cross-referenced by using dates.

Space Experiment Module (SEM)

NASA Technical Reports Server (NTRS)

Brodell, Charles L.

1999-01-01

The Space Experiment Module (SEM) Program is an education initiative sponsored by the National Aeronautics and Space Administration (NASA) Shuttle Small Payloads Project. The program provides nationwide educational access to space for Kindergarten through University level students. The SEM program focuses on the science of zero-gravity and microgravity. Within the program, NASA provides small containers or "modules" for students to fly experiments on the Space Shuttle. The experiments are created, designed, built, and implemented by students with teacher and/or mentor guidance. Student experiment modules are flown in a "carrier" which resides in the cargo bay of the Space Shuttle. The carrier supplies power to, and the means to control and collect data from each experiment.

Space civil engineering - A new discipline

NASA Technical Reports Server (NTRS)

Sadeh, Willy Z.; Criswell, Marvin E.

1991-01-01

Space Civil Engineering is an emerging engineering discipline that focuses on extending and expanding the Civil Engineering know-how and practice to the development and maintenance of infrastructure on celestial bodies. Space Civil Engineering is presently being developed as a new discipline within the Department of Civil Engineering at Colorado State University under a recently established NASA Space Grant College Program. Academic programs geared toward creating Space Civil Engineering Options at both undergraduate and graduate levels are being formulated. Basic ideas and concepts of the curriculum in the Space Civil Engineering Option at both undergraduate and graduate levels are presented. The role of Space Civil Engineering in the Space Program is discussed.

Modular space station, phase B extension. Program operations plan

NASA Technical Reports Server (NTRS)

1971-01-01

An organized approach is defined for establishing the most significant requirements pertaining to mission operations, information management, and computer program design and development for the modular space station program. The operations plan pertains to the space station and experiment module program elements and to the ground elements required for mission management and mission support operations.

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA), speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA), speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, speaks to guests and the media gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, speaks to guests and the media gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, speaks to guests and the media gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, speaks to guests and the media gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module (above right) of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module (above right) of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (far left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr. (second from left); NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, media and guests listen intently to remarks during a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony included these speakers: KSC Director Roy Bridges Jr.; NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, media and guests listen intently to remarks during a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony included these speakers: KSC Director Roy Bridges Jr.; NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - At ceremony highlighting the arrival of two major components of the International Space Station, Node 2 and the Japanese Experiment Module (JEM), ownership of Node 2 was officially transferred between the European Space Agency and NASA. Shaking hands after the signing are Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA). At right is NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - At ceremony highlighting the arrival of two major components of the International Space Station, Node 2 and the Japanese Experiment Module (JEM), ownership of Node 2 was officially transferred between the European Space Agency and NASA. Shaking hands after the signing are Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Alan Thirkettle, International Space Station Program manager for Node 2, European Space Agency (ESA). At right is NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs. NASA's Node 2, built by ESA in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s William Gerstenmaier, International Space Station Program manager; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (left) , deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (left) , deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Center Director Roy Bridges Jr. speaks to the media and guests gathered in the Space Station Processing Facility for a ceremony to highlight the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope) arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone (left), deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: NASA's Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs, and William Gerstenmaier, International Space Station Program manager; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan, speaks to guests and the media gathered in the Space Station Processing Facility at a ceremony highlighting the arrival of two major components of the International Space Station. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs and William Gerstenmaier, International Space Station Program manager ; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; and Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency.

KENNEDY SPACE CENTER, FLA. - At a ceremony highlighting the arrival of two major components of the International Space Station, William Gerstenmaier, International Space Station Program manager, points to one of the components as he speaks to guests and the media gathered in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

NASA Image and Video Library

2003-06-18

KENNEDY SPACE CENTER, FLA. - At a ceremony highlighting the arrival of two major components of the International Space Station, William Gerstenmaier, International Space Station Program manager, points to one of the components as he speaks to guests and the media gathered in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station. The ceremony held today included the official transfer of ownership signing of Node 2 between the ESA and NASA.. Emceed by Lisa Malone, deputy director of External Relations and Business Development at KSC, the ceremony also included these speakers: Center Director Roy Bridges Jr.; NASA’s Michael C. Kostelnik, deputy associate administrator for International Space Station and Shuttle Programs; Alan Thirkettle, International Space Station Program manager for Node 2, ESA; Andrea Lorenzoni, International Space Station Program manager for Node 2, Italian Space Agency; and Kuniaki Shiraki, JEM Project manager, National Aerospace and Development Agency of Japan.

A crisis in the NASA space and earth sciences programme

NASA Technical Reports Server (NTRS)

Lanzerotti, Louis, J.; Rosendhal, Jeffrey D.; Black, David C.; Baker, D. James; Banks, Peter M.; Bretherton, Francis; Brown, Robert A.; Burke, Kevin C.; Burns, Joseph A.; Canizares, Claude R.

1987-01-01

Problems in the space and earth science programs are examined. Changes in the research environment and requirements for the space and earth sciences, for example from small Explorer missions to multispacecraft missions, have been observed. The need to expand the computational capabilities for space and earth sciences is discussed. The effects of fluctuations in funding, program delays, the limited number of space flights, and the development of the Space Station on research in the areas of astronomy and astrophysics, planetary exploration, solar and space physics, and earth science are analyzed. The recommendations of the Space and Earth Science Advisory Committee on the development and maintenance of effective space and earth sciences programs are described.

SpaceX CRS-12 Prelaunch News Conference

NASA Image and Video Library

2017-08-13

In the Kennedy Space Center’s Press Site auditorium, agency and industry leaders speak to members of the media during a prelaunch news conference for the SpaceX CRS-12 commercial resupply services mission to the International Space Station. Josh Finch of NASA Communications; Dan Hartman, NASA deputy manager of the International Space Station Program, Hans Koenigsmann, vice president of Build and Flight Reliability for SpaceX, and Pete Hasbrook, associate program scientist for the International Space Station Program. A Dragon spacecraft is scheduled to be launched from Kennedy’s Launch Complex 39A on Aug. 14 atop a SpaceX Falcon 9 rocket on the company's 12th Commercial Resupply Services mission to the space station.

Report of the Advisory Committee on the Future of the US Space Program

NASA Technical Reports Server (NTRS)

1990-01-01

The United States' civil space program was rather hurriedly formulated some three decades ago on the heels of the successful launch of the Soviet Sputnik. A dozen humans have been placed on the Moon and safely returned to Earth, seven of the other eight planets have been viewed at close range, including the soft landing of two robot spacecraft on Mars, and a variety of significant astronomical and other scientific observations have been accomplished. Closer to Earth, a network of communications satellites has been established, weather and ocean conditions are now monitored and reported as they occur, and the Earth's surface is observed from space to study natural resources and detect sources of pollution. Problems and perspectives of the program are given as seen by the committee. The committee finds that there are nine concerns about the space program which are deserving of attention. The responsibilities of the agency are given. The space agenda becomes one of what can and should the U.S. afford for its space program. Also given is a concept of what the committee believes is a balanced space program. The programs international role is defined and some final observations and recommendations are made.

Project Mercury: Man-In-Space Program of the National Aeronautics and Space Administration. [Report of the Committee on Aeronautical and Space Sciences United States Senate

NASA Technical Reports Server (NTRS)

1959-01-01

The purpose of this staff study, made at the request of the chairman, is to serve members of the Committee on Aeronautical and Space Sciences as a source of basic information on Project Mercury, the man-in-space program of the National Aeronautics and Space Administration. The study is largely derived from unclassified information released by the National Aeronautics and Space Administration and testimony concerning Project Mercury given during hearings before this committee. The program descriptions are based upon current program planning. Since this is a highly advanced research and development program, the project is obviously subject to changes that may result from future developments and accomplishments characteristic of such research activities. Certain information with respect to revised schedules, obtained on a classified basis by the committee during inspection trips, is necessarily omitted. The appendixes to the study include information that may prove helpful on various aspects of space flight and exploration. Included are unofficial comments and observations relating to Russia's manned space flight activities and also a complete chronology of all satellites, lunar probes, and space probes up to the present.

High Frontier: The Journal for Space and Missile Professionals. Volume 7, Number 4, August 2011

DTIC Science & Technology

2011-08-01

assess the role of space assets in military operations and the relationship between “white” and “ black ” space—those programs acknowledged and...economize, ratio- nalize, and eventually re-energize the “ black ” space programs in relationship to the “white” programs managed by DoD. Fi- nally, it...Negroponte. Significant issues related to national security space, primarily those affecting the “ black ” programs, were resolved by this EXCOM. By all

Research and technology operating plan summary: Fiscal year 1975 research and technology program. [space programs, energy technology, and aerospace sciences

NASA Technical Reports Server (NTRS)

1975-01-01

Summaries are presented of Research and Technology Operating Plans currently in progress throughout NASA. Citations and abstracts of the operating plans are presented along with a subject index, technical monitor index, and responsible NASA organization index. Research programs presented include those carried out in the Office of Aeronautics and Space Technology, Office of Energy Programs, Office of Applications, Office of Space Sciences, Office of Tracking and Data Acquisition, and the Office of Manned Space Flight.

Industry-university cooperation/research

NASA Technical Reports Server (NTRS)

Whitten, Raymond P.

1991-01-01

The paper concentrates on the commercial development of space programs through cooperative research with the U.S. universities and industry. The origins of the programs are discussed, beginning with the Communication Satellite Act of 1963. The National Space Policy is outlined, and the creation of NASA's Office of Commercial Programs is emphasized, along with its Centers for the Commercial Development of Space. It is noted that the centers are consortia of university, industry, and government involved in commercial-space-technology database development and research and testing of potentially valuable products and services. The center titles, locations, and brief descriptions for such area of research as remote sensing, life sciences, materials processing, space power, space propulsion, materials and space structures, and automation and robotics centers are listed, along with some results of the programs.

KSC-2012-4583

NASA Image and Video Library

2012-08-23

CAPE CANAVERAL, Fla. -- Inside the Space Exploration Technologies, or SpaceX, processing facility near NASA’s Kennedy Space Center in Florida, Scott Thurston, partner integration office manager with the Commercial Crew Program, talks to the media prior to an announcement from NASA Administrator Charles Bolden about new milestones in the nation’s commercial space initiatives. Bolden announced that SpaceX has completed its Space Act Agreement with NASA for Commercial Orbital Transportation Services. SpaceX is scheduled to launch the first of its 12 contracted cargo flights to the space station from Cape Canaveral this October, under NASA’s Commercial Resupply Services Program. Bolden also announced NASA partner Sierra Nevada Corp. has conducted its first milestone under the agency’s recently announced Commercial Crew Integrated Capability initiative. The milestone, a program implementation plan review, marks an important first step in Sierra Nevada’s efforts to develop a crew transportation system with its Dream Chaser spacecraft. Through NASA’s commercial space initiatives and programs, the agency is providing investments to stimulate the American commercial space industry. Photo credit: NASA/Kim Shiflett

Space station interior noise analysis program

NASA Technical Reports Server (NTRS)

Stusnick, E.; Burn, M.

1987-01-01

Documentation is provided for a microcomputer program which was developed to evaluate the effect of the vibroacoustic environment on speech communication inside a space station. The program, entitled Space Station Interior Noise Analysis Program (SSINAP), combines a Statistical Energy Analysis (SEA) prediction of sound and vibration levels within the space station with a speech intelligibility model based on the Modulation Transfer Function and the Speech Transmission Index (MTF/STI). The SEA model provides an effective analysis tool for predicting the acoustic environment based on proposed space station design. The MTF/STI model provides a method for evaluating speech communication in the relatively reverberant and potentially noisy environments that are likely to occur in space stations. The combinations of these two models provides a powerful analysis tool for optimizing the acoustic design of space stations from the point of view of speech communications. The mathematical algorithms used in SSINAP are presented to implement the SEA and MTF/STI models. An appendix provides an explanation of the operation of the program along with details of the program structure and code.

Exploring the Unknown: Selected Documents in the History of the U.S. Civilian Space Program. Volume 2; External Relationships

NASA Technical Reports Server (NTRS)

Logsdon, John M. (Editor); Day, Dwayne A. (Editor); Launius, Roger D. (Editor)

1996-01-01

The documents selected for inclusion in this volume are presented in three chapters, each covering a particular aspect of the evolution of U.S. space exploration. These chapters address (1) the relations between the civilian space program of the United States and the space activities of other countries, (2) the relations between the U.S. civilian space program and the space efforts of national security organizations and the military, and (3) NASA's relations with industry and academic institutions.

KSC-03PD-3240

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, United Space Alliance (USA) Director of Orbiter Operations Patty Stratton, and NASA Space Shuttle Program Manager William Parsons view the underside of Shuttle Discovery in Orbiter Processing Facility Bay 3. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KSC-03PD-3249

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA's In-Space Technology Experiments Program

NASA Technical Reports Server (NTRS)

Levine, J.; Prusha, S. L.

1992-01-01

The objective of the In-Space Technology Experiments Program is to evaluate and validate innovative space technologies and to provide better knowledge of the effects of microgravity and the space environment. The history, organization, methodology, and current program characteristics are presented. Results of the tank pressure control experiment and the middeck zero-gravity dynamics experiment are described to demonstrate the types of technologies that have flown and the experimental results obtained from these low-cost space flight experiments.

National Directory of NASA Space Grant Contacts

NASA Technical Reports Server (NTRS)

2002-01-01

Congress enacted the National Space Grant College and Fellowship Program (also known as Space Grant). NASA's Space Grant Program funds education, research, and public service programs in all 50 States, the District of Columbia, and the Commonwealth of Puerto Rico through 52 university-based Space Grant consortia. These consortia form a network of colleges and universities, industry partners, State and local Government agencies, other Federal agencies, museum and science centers, and nonprofit organizations, all with interests in aerospace education, research, and training. Space Grant programs emphasize the diversity of human resources, the participation of students in research, and the communication of the benefits of science and technology to the general public. Each year approximately one-third of the NASA Space Grant funds support scholarships and fellowships for United States students at the undergraduate and graduate levels. Typically, at least 20 percent of these awards go to students from underrepresented groups, and at least 40 percent go to women. Most Space Grant student awards include a mentored research experience with university faculty or NASA scientists or engineers. Space Grant consortia also fund curriculum enhancement and faculty development programs. Consortia members administer precollege and public service education programs in their States. The 52 consortia typically leverage NASA funds with matching contributions from State, local, and other university sources, which more than double the NASA funding. For more information, consult the Space Grant Web site at http://education.nasa.gov/spacegrant/

Rocket engine exhaust plume diagnostics and health monitoring/management during ground testing

NASA Technical Reports Server (NTRS)

Chenevert, D. J.; Meeks, G. R.; Woods, E. G.; Huseonica, H. F.

1992-01-01

The current status of a rocket exhaust plume diagnostics program sponsored by NASA is reviewed. The near-term objective of the program is to enhance test operation efficiency and to provide for safe cutoff of rocket engines prior to incipient failure, thereby avoiding the destruction of the engine and the test complex and preventing delays in the national space program. NASA programs that will benefit from the nonintrusive remote sensed rocket plume diagnostics and related vehicle health management and nonintrusive measurement program are Space Shuttle Main Engine, National Launch System, National Aero-Space Plane, Space Exploration Initiative, Advanced Solid Rocket Motor, and Space Station Freedom. The role of emission spectrometry and other types of remote sensing in rocket plume diagnostics is discussed.

Space Alliance Technology Outreach Program

NASA Technical Reports Server (NTRS)

2005-01-01

Space Alliance Technology Outreach Program (SATOP), will provide technical assistance to small businesses through the contribution of time and expertise from Space Alliance Partners and support the development and expansion of technology business incubation programs in Florida and New York. A summary of these accomplishments are given.

The Evolution of Failure Analysis at NASA's Kennedy Space Center and the Lessons Learned

NASA Technical Reports Server (NTRS)

Long, Victoria S.; Wright, M. Clara; McDanels, Steve

2015-01-01

The United States has had four manned launch programs and three station programs since the era of human space flight began in 1961. The launch programs, Mercury, Gemini, Apollo, and Shuttle, and the station programs, Skylab, Shuttle-Mir, and the International Space Station (ISS), have all been enormously successful, not only in advancing the exploration of space, but also in advancing related technologies. As each subsequent program built upon the successes of previous programs, they similarly learned from their predecessors' failures. While some failures were spectacular and captivated the attention of the world, most only held the attention of the dedicated men and women working to make the missions succeed.

Early Program Development

NASA Image and Video Library

1969-01-01

As part of the Space Task Group's recommendations for more commonality and integration in America's space program, Marshall Space Flight Center engineers proposed an orbiting propellant storage facility to augment Space Shuttle missions. In this artist's concept from 1969 an early version of the Space Shuttle is shown refueling at the facility.

76 FR 15039 - Commercial Space Transportation Grants Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... proposals for the Commercial Space Transportation Grant Program. SUMMARY: This notice solicits Fiscal Year (FY) 2011 grant proposals to continue the development of a Commercial Space Transportation...

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Manager of the Thermal Protection System (TPS) Facility Martin Wilson (right) briefs NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) on the properties of a thermal blanket used in the Shuttle's TPS. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Manager of the Thermal Protection System (TPS) Facility Martin Wilson (right) briefs NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) on the properties of a thermal blanket used in the Shuttle's TPS. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) discusses some of the working parts inside the nose of Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (back to camera). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) discusses some of the working parts inside the nose of Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (back to camera). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Space science

NASA Technical Reports Server (NTRS)

1975-01-01

A fact sheet on the NASA space science program is presented. Some of the subjects considered include the following: (1) the Orbiting Astronomical Observatory, (2) the Orbiting Solar Observatory, (3) the Small Astronomy Satellite, (4) lunar programs, (5) planetary programs using the Mariner, Pioneer 10, and Viking space probes, and (6) the Scout, Thor-Delta, and Atlas-Centaur launch vehicles. For each program there is a description of the effort, the schedule, management, program officials, and funding aspects in outline form.

Shuttle - Mir Program Insignia

NASA Image and Video Library

1994-09-20

The rising sun signifies the dawn of a new era of human Spaceflight, the first phase of the United States/Russian space partnership, Shuttle-Mir. Mir is shown in its proposed final on orbit configuration. The Shuttle is shown in a generic tunnel/Spacehab configuration. The Shuttle/Mir combination, docked to acknowledge the union of the two space programs, orbits over an Earth devoid of any definable features or political borders to emphasize Earth as the home planet for all humanity. The individual stars near the Space Shuttle and the Russian Mir Space Station represent the previous individual accomplishments of Russia's space program and that of the United States. The binary star is a tribute to the previous United States-Russian joint human Spaceflight program, the Apollo-Soyuz Test Project (ASTP). The flags of the two nations are symbolized by flowing ribbons of the national colors interwoven in space to represent the two nations joint exploration of space. NASA SHUTTLE and PKA MNP are shown in the stylized logo fonts of the two agencies that are conducting this program.

Spacecraft Power Systems Engineering: Solutions for NASA's Manned Space Program

NASA Technical Reports Server (NTRS)

Scott, John H.

2007-01-01

An overview of spacecraft power systems is presented, with a focus on applications in the manned space program. The topics include: 1) History; 2) State-of-the-art; 3) Development directions; 4) Focus on applications in the manned space program led from JSC; 5) Power Systems Engineering Trade Space; 6) Power Generation and Energy Storage; 7) Power Distribution and Control; and 8) Actuation

Educational planning for utilization of space shuttle (ED-PLUSS). Executive summary: Identification and evaluation of educational uses and users for the STS

NASA Technical Reports Server (NTRS)

Engle, H. A.; Christensen, D. L.

1975-01-01

The development and application of educational programs to improve public awareness of the space shuttle/space lab capabilities are reported. Special efforts were made to: identify the potential user, identify and analyze space education programs, plan methods for user involvement, develop techniques and programs to encourage new users, and compile follow-on ideas.

National Space Weather Program Advances on Several Fronts

NASA Astrophysics Data System (ADS)

Gunzelman, Mark; Babcock, Michael

2008-10-01

The National Space Weather Program (NSWP; http://www.nswp.gov) is a U.S. federal government interagency initiative through the Office of the Federal Coordinator for Meteorology that was created to speed the improvement of space weather services for the nation. The Committee for Space Weather (CSW) under the NSWP has continued to advance the program on a number of fronts over the past 12 months.

Progress in space power technology

NASA Technical Reports Server (NTRS)

Mullin, J. P.; Randolph, L. P.; Hudson, W. R.

1980-01-01

The National Aeronautics and Space Administration's Space Power Research and Technology Program has the objective of providing the technology base for future space power systems. The current technology program which consists of photovoltaic energy conversion, chemical energy conversion and storage, thermal-to-electric conversion, power systems management and distribution, and advanced energetics is discussed. In each area highlights, current programs, and near-term directions will be presented.

The first Chinese student space shuttle getaway special program

NASA Technical Reports Server (NTRS)

Lee, Mark C.; Jin, Xun-Shu; Ke, Shou-Quan; Fu, Bing-Chen

1988-01-01

The first Chinese Getaway Special program is described. Program organization, the student proposal evaluation procedure, and the objectives of some of the finalist's experiments are covered. The two experiments selected for eventual flight on the space shuttle are described in detail. These include: (1) the control of debris in the cabin of the space shuttle; and (2) the solidification of two immiscible liquids in space.

The Chinese student space shuttle get-way-special program

NASA Technical Reports Server (NTRS)

Lee, Mark C.; Jin, Xun-Shu; Ke, Shou-Quan; Fu, Bing-Chen

1989-01-01

The first Chinese Getaway Special program is described. Program organization, the student proposal evaluation procedure, and the objectives of some of the finalist's experiments are covered. The two experiments selected for eventual flight on the space shuttle are described in detail. These include: (1) the control of debris in the cabin of the space shuttle; and (2) the solidification of two immiscible liquids in space.

Human factors technology for America's space program

NASA Technical Reports Server (NTRS)

Montemerlo, M. D.

1982-01-01

NASA is initiating a space human factors research and technology development program in October 1982. The impetus for this program stems from: the frequent and economical access to space provided by the Shuttle, the advances in control and display hardware/software made possible through the recent explosion in microelectronics technology, heightened interest in a space station, heightened interest by the military in space operations, and the fact that the technology for long duration stay times for man in space has received relatively little attention since the Apollo and Skylab missions. The rationale for and issues in the five thrusts of the new program are described. The main thrusts are: basic methodology, crew station design, ground control/operations, teleoperations and extra vehicular activity.

Challenges and Future Opportunities in Our Nation's Space Program

NASA Technical Reports Server (NTRS)

Clements, Greg

2011-01-01

For the first time in decades, there is a significant amount of change in our nation's space program. Along with change, there are opportunities, and NASA has begun a set of planning to be prepared for the future, emphasizing innovation and technology development, increased emphasis on collaboration, commercially-provided access to space, and the need for reinvention. This discussion will briefly give an overview of NASA, showcase some of the diverse activities that are part of our nation' fs space program, identify some of the new changes envisioned to NASA's mission, and how our space program can continue to inspire the nation during changing times.

The NASA technology push towards future space mission systems

NASA Technical Reports Server (NTRS)

Sadin, Stanley R.; Povinelli, Frederick P.; Rosen, Robert

1988-01-01

As a result of the new Space Policy, the NASA technology program has been called upon to a provide a solid base of national capabilities and talent to serve NASA's civil space program, commercial, and other space sector interests. This paper describes the new technology program structure and its characteristics, traces its origin and evolution, and projects the likely near- and far-term strategic steps. It addresses the alternative 'push-pull' approaches to technology development, the readiness levels to which the technology needs to be developed for effective technology transfer, and the focused technology programs currently being implemented to satisfy the needs of future space systems.

KSC All Hands

NASA Image and Video Library

2018-01-11

Josie Burnett, director or Exploration Research and Technology Programs, speaks to Kennedy Space Center employees about plans for the coming year. The event took place in the Lunar Theater at the Kennedy Space Center Visitor Complex’s Apollo Saturn V Center. The year will be highlighted with NASA's partners preparing test flights for crewed missions to the International Space Station as part of the agency's Commercial Crew Program and six launches by the Launch Services Program. Exploration Ground Systems will be completing facilities to support the Space Launch System rocket and Orion spacecraft. Exploration Research and Technology Programs will continue to provide supplies to the space station launched as part of the Commercial Resupply Services effort.

Research and technology, 1984: Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Moorehead, T. W. (Editor)

1984-01-01

The Marshall Space Flight Center conducts research programs in space sciences, materials processing in space, and atmospheric sciences, as well as technology programs in such areas as propulsion, materials, processes, and space power. This Marshall Space Flight Center 1984 Annual Report on Research and Technology contains summaries of the more significant scientific and technical results obtained during FY-84.

Report of the Committee on the Space Station of the National Research Council

NASA Technical Reports Server (NTRS)

1987-01-01

The Space Station Program will be the most ambitious space project the nation has ever undertaken; will require tens of billions of dollars; and will entwine for many years the space program with those of international partners. It must have enduring stable support across administrations, and the support must be generous. The current Space Shuttle is barely adequate for the limited purpose of deploying the Space Station, and it is inadequate to meet broader national needs in space. The Committee recommends in the strongest terms that the Shuttle be upgraded with new improved solid rocket motors, that it be supplemented with expendable launch vehicles, and that a heavy lift launch vehicle be developed for use in the latter half of the 1990s. The Committee strongly recommends that NASA prepare a new Space Station Program cost estimate in conjunction with the Program Requirements Review scheduled for early next year by NASA. The exercise should address the full range of uncertainties in the current Program, some of which are discussed in the report.

Safety, reliability, maintainability and quality provisions for the Space Shuttle program

NASA Technical Reports Server (NTRS)

1990-01-01

This publication establishes common safety, reliability, maintainability and quality provisions for the Space Shuttle Program. NASA Centers shall use this publication both as the basis for negotiating safety, reliability, maintainability and quality requirements with Shuttle Program contractors and as the guideline for conduct of program safety, reliability, maintainability and quality activities at the Centers. Centers shall assure that applicable provisions of the publication are imposed in lower tier contracts. Centers shall give due regard to other Space Shuttle Program planning in order to provide an integrated total Space Shuttle Program activity. In the implementation of safety, reliability, maintainability and quality activities, consideration shall be given to hardware complexity, supplier experience, state of hardware development, unit cost, and hardware use. The approach and methods for contractor implementation shall be described in the contractors safety, reliability, maintainability and quality plans. This publication incorporates provisions of NASA documents: NHB 1700.1 'NASA Safety Manual, Vol. 1'; NHB 5300.4(IA), 'Reliability Program Provisions for Aeronautical and Space System Contractors'; and NHB 5300.4(1B), 'Quality Program Provisions for Aeronautical and Space System Contractors'. It has been tailored from the above documents based on experience in other programs. It is intended that this publication be reviewed and revised, as appropriate, to reflect new experience and to assure continuing viability.

The U.S. Space Grant College and Fellowship Program

NASA Technical Reports Server (NTRS)

Dasch, E. Julius; Schwartz, Elaine T.; Keffer, Lynne

1990-01-01

The U.S. NASA Space Grant College and Fellowship Program, congressionally mandated in 1987, consists of two phases. Phase I consisted of the designation of 21 university consortia as 'Space Grant Colleges/Consortia' which received support from NASA to conduct programs to achieve, maintain, and advance a balanced program of research capability, curriculum, and public service. Program descriptions for phase II are given. This phase is designed to broaden participation in the Space Grant Program by targeting states that currently are not as involved in NASA programs as are the states for which phase I was constructed. Under phase II, states will compete in either the Programs Grants or the Capability Enhancement Grants category. Only one proposal per state will be accepted with the state determining in which category it will compete. The amount of total award, $150,000, is the same in both categories and includes funds for university-administered fellowship programs.