7 CFR 3431.15 - Qualifying loans.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE VETERINARY MEDICINE LOAN REPAYMENT PROGRAM Administration of the Veterinary Medicine Loan Repayment Program § 3431.15... individual for attendance of the individual at an accredited college of veterinary medicine resulting in a...

Influence of a School District's Advancement via Individual Determination (AVID) Program on Self-Efficacy and Other Indicators of Student Achievement

ERIC Educational Resources Information Center

Pugh, Philip M.; Tschannen-Moran, Megan

2016-01-01

This article examines a school district's Advancement via Individual Determination (AVID) program using perceived self-efficacy in academic achievement and self-regulated learning, GPA and attendance as indicators of program effectiveness. Results suggest that AVID participation was positively and significantly correlated with attendance in the…

34 CFR 300.22 - Individualized education program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Individualized education program. 300.22 Section 300.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

34 CFR 300.112 - Individualized education programs (IEP).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.112 - Individualized education programs (IEP).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.112 - Individualized education programs (IEP).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 2 2013-07-01 2013-07-01 false Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.22 - Individualized education program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false Individualized education program. 300.22 Section 300.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

34 CFR 300.112 - Individualized education programs (IEP).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.22 - Individualized education program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true Individualized education program. 300.22 Section 300.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

34 CFR 300.22 - Individualized education program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 2 2013-07-01 2013-07-01 false Individualized education program. 300.22 Section 300.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

34 CFR 300.23 - Individualized education program team.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Individualized education program team. 300.23 Section 300.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.112 - Individualized education programs (IEP).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE...

34 CFR 300.22 - Individualized education program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Individualized education program. 300.22 Section 300.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

Assistance to States for the Education of Children with Disabilities and the Early Intervention Program for Infants and Toddlers with Disabilities. Final Regulations. Federal Register, Part II, Department of Education, 34 CFR Parts 300 and 303.

ERIC Educational Resources Information Center

Federal Register, 1999

1999-01-01

This document presents final regulations for the Assistance to States for Education of Children with Disabilities program under Part B of the Individuals with Disabilities Act (IDEA Part B) and the Early Intervention Program for Infants and Toddlers with Disabilities under Part C of the Act. These regulations are needed to implement changes made…

48 CFR 19.506 - Withdrawing or modifying small business set-asides.

Code of Federal Regulations, 2010 CFR

2010-10-01

... a withdrawal of an individual small business set-aside by giving written notice to the agency small... small business set-asides. 19.506 Section 19.506 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 19.506...

34 CFR 367.1 - What is the Independent Living Services for Older Individuals Who Are Blind program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true What is the Independent Living Services for Older Individuals Who Are Blind program? 367.1 Section 367.1 Education Regulations of the Offices of the Department... EDUCATION INDEPENDENT LIVING SERVICES FOR OLDER INDIVIDUALS WHO ARE BLIND General § 367.1 What is the...

34 CFR 367.1 - What is the Independent Living Services for Older Individuals Who Are Blind program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What is the Independent Living Services for Older Individuals Who Are Blind program? 367.1 Section 367.1 Education Regulations of the Offices of the Department... EDUCATION INDEPENDENT LIVING SERVICES FOR OLDER INDIVIDUALS WHO ARE BLIND General § 367.1 What is the...

MEF2 Transcription Factors Regulate Distinct Gene Programs in Mammalian Skeletal Muscle Differentiation*

PubMed Central

Estrella, Nelsa L.; Desjardins, Cody A.; Nocco, Sarah E.; Clark, Amanda L.; Maksimenko, Yevgeniy; Naya, Francisco J.

2015-01-01

Skeletal muscle differentiation requires precisely coordinated transcriptional regulation of diverse gene programs that ultimately give rise to the specialized properties of this cell type. In Drosophila, this process is controlled, in part, by MEF2, the sole member of an evolutionarily conserved transcription factor family. By contrast, vertebrate MEF2 is encoded by four distinct genes, Mef2a, -b, -c, and -d, making it far more challenging to link this transcription factor to the regulation of specific muscle gene programs. Here, we have taken the first step in molecularly dissecting vertebrate MEF2 transcriptional function in skeletal muscle differentiation by depleting individual MEF2 proteins in myoblasts. Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process. Furthermore, despite the extensive redundancy, we show that mammalian MEF2 proteins regulate a significant subset of nonoverlapping gene programs. These results suggest that individual MEF2 family members are able to recognize specific targets among the entire cohort of MEF2-regulated genes in the muscle genome. These findings provide opportunities to modulate the activity of MEF2 isoforms and their respective gene programs in skeletal muscle homeostasis and disease. PMID:25416778

Cycling for Students with ASD: Self-Regulation Promotes Sustained Physical Activity

ERIC Educational Resources Information Center

Todd, Teri; Reid, Greg; Butler-Kisber, Lynn

2010-01-01

Individuals with autism often lack motivation to engage in sustained physical activity. Three adolescents with severe autism participated in a 16-week program and each regularly completed 30 min of cycling at the end of program. This study investigated the effect of a self-regulation instructional strategy on sustained cycling, which included…

5 CFR 362.102 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS General... written agreement between the agency and each Pathways Participant. Program Participant or Pathways Participant means any individual appointed under a Pathways Program. Qualifying educational institution means...

5 CFR 362.102 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS General... written agreement between the agency and each Pathways Participant. Program Participant or Pathways Participant means any individual appointed under a Pathways Program. Qualifying educational institution means...

34 CFR Appendix A to Part 361 - Questions and Answers

Code of Federal Regulations, 2011 CFR

2011-07-01

... purposes of the VR program to mean outcomes that occur in integrated settings will promote the provision of opportunities for all VR-eligible individuals to pursue the types of jobs that generally are available to the... extended employment outside of the VR program, and these regulations ensure that those individuals' needs...

34 CFR Appendix A to Part 361 - Questions and Answers

Code of Federal Regulations, 2014 CFR

2014-07-01

... purposes of the VR program to mean outcomes that occur in integrated settings will promote the provision of opportunities for all VR-eligible individuals to pursue the types of jobs that generally are available to the... extended employment outside of the VR program, and these regulations ensure that those individuals' needs...

49 CFR 240.103 - Approval of design of individual railroad programs by FRA.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Approval of design of individual railroad programs by FRA. 240.103 Section 240.103 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION QUALIFICATION AND CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the...

Health Risk Reduction Programs in Employer-Sponsored Health Plans: Part II—Law and Ethics

PubMed Central

Rothstein, Mark A.; Harrell, Heather L.

2011-01-01

Objective We sought to examine the legal and ethical implications of workplace health risk reduction programs (HRRPs) using health risk assessments, individually focused risk reduction, and financial incentives to promote compliance. Methods We conducted a literature review, analyzed relevant statutes and regulations, and considered the effects of these programs on employee health privacy. Results A variety of laws regulate HRRPs, and there is little evidence that employer-sponsored HRRPs violate these provisions; infringement on individual health privacy is more difficult to assess. Conclusion Although current laws permit a wide range of employer health promotion activities, HRRPs also may entail largely unquantifiable costs to employee privacy and related interests. PMID:19625971

Missouri State Plan for Special Education: Regulations Implementing Part C of the Individuals with Disabilities Education Act First Steps Program

ERIC Educational Resources Information Center

Nicastro, Chris L.

2010-01-01

The State of Missouri has adopted the definitions in 34 Code of Federal Regulations (CFR) 303.5-303.24 of the Part C regulations and selected terms as defined in 34 CFR 77.1 and 74.3 for use in implementing the State's early intervention program. The Department of Elementary and Secondary Education (DESE) is the lead agency responsible for…

Missouri State Plan for Special Education: Regulations Implementing Part C of the Individuals with Disabilities Education Act First Steps Program. Revised

ERIC Educational Resources Information Center

Nicastro, Chris L.

2012-01-01

The State of Missouri has adopted the definitions in 34 Code of Federal Regulations (CFR) 303.5-303.24 of the Part C regulations and selected terms as defined in 34 CFR 77.1 and 74.3 for use in implementing the State's early intervention program. The Department of Elementary and Secondary Education (DESE) is the lead agency responsible for…

75 FR 33704 - Loan Guaranty: Elimination of Redundant Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... budgetary impact of entitlements, grants, user fees, or loan programs or the rights and obligations of..., Handicapped, Housing, Indians, Individuals with disabilities, Loan programs--housing and community development...

Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks

PubMed Central

Roy, Sushmita; Lagree, Stephen; Hou, Zhonggang; Thomson, James A.; Stewart, Ron; Gasch, Audrey P.

2013-01-01

Regulatory networks that control gene expression are important in diverse biological contexts including stress response and development. Each gene's regulatory program is determined by module-level regulation (e.g. co-regulation via the same signaling system), as well as gene-specific determinants that can fine-tune expression. We present a novel approach, Modular regulatory network learning with per gene information (MERLIN), that infers regulatory programs for individual genes while probabilistically constraining these programs to reveal module-level organization of regulatory networks. Using edge-, regulator- and module-based comparisons of simulated networks of known ground truth, we find MERLIN reconstructs regulatory programs of individual genes as well or better than existing approaches of network reconstruction, while additionally identifying modular organization of the regulatory networks. We use MERLIN to dissect global transcriptional behavior in two biological contexts: yeast stress response and human embryonic stem cell differentiation. Regulatory modules inferred by MERLIN capture co-regulatory relationships between signaling proteins and downstream transcription factors thereby revealing the upstream signaling systems controlling transcriptional responses. The inferred networks are enriched for regulators with genetic or physical interactions, supporting the inference, and identify modules of functionally related genes bound by the same transcriptional regulators. Our method combines the strengths of per-gene and per-module methods to reveal new insights into transcriptional regulation in stress and development. PMID:24146602

34 CFR 100.12 - Effect on other regulations; forms and instructions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... designed to prohibit any discrimination against individuals on the ground of race, color, or national..., color, or national origin in any program or situation to which this regulation is inapplicable, or...

41 CFR 101-6.204-2 - Specific discriminatory actions prohibited.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REGULATIONS 6.2-Nondiscrimination in Programs Receiving Federal Financial Assistance § 101-6.204-2 Specific... under the program (including the opportunity to participate in the program as an employee but only to... defeating or substantially impairing accomplishment of the objectives of the program as respect individuals...

Federal privacy regulations and the provision of Early Hearing Detection and Intervention programs.

PubMed

Houston, K Todd; Behl, Diane D; White, Karl R; Forsman, Irene

2010-08-01

To be successful, Early Hearing Detection and Intervention (EHDI) programs require individually identifiable information about children to be shared among people who are responsible for screening, diagnosis, early intervention, family support, and medical home services. Pediatricians and other stakeholders in the EHDI process often point to federal laws that were passed to ensure privacy and confidentiality in health care and educational programs as major obstacles to achieving efficient and effective EHDI programs. In this article we summarize the provisions of 3 federal laws (the Health Insurance Portability and Accountability Act [HIPAA], the Family Education Rights and Privacy Act [FERPA], and Part C privacy regulations of the Individuals With Disabilities Education Act [IDEA]) that most directly affect information-sharing in EHDI programs. We suggest strategies for sharing the information needed to operate successful EHDI programs while remaining in compliance with these laws, including obtaining signed parental consent to share information between providers, including an option on the individual family services plan for parents to permit sharing of the plan with pediatricians and other providers, and giving copies of all relevant test results to parents to share with providers as they wish.

48 CFR 2801.603-1 - Department of Justice Acquisition Career Management Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Representatives, or equivalent positions. (c) The program shall include: (1) Management information system... acquisition workforce management information system. (2) Individual assessments and development plans for... Acquisition Career Management Program. 2801.603-1 Section 2801.603-1 Federal Acquisition Regulations System...

A Review of Federal and State Regulations for Day Care Programs and Facilities. Center for Human Services Development Report No. 10.

ERIC Educational Resources Information Center

Hollick, Rosemary; And Others

This report provides a review of U.S. regulatory standards for day care programs and facilities and makes recommendations for the revision of day care regulations in Pennsylvania. Following a brief discussion of federal interagency requirements, a number of short descriptive analyses compare individual state standards in the areas of licensing,…

48 CFR 1624.104 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 1624.104 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1624.104 Contract clause. Records retained by FEHBP carriers on...

48 CFR 1624.104 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 1624.104 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1624.104 Contract clause. Records retained by FEHBP carriers on...

48 CFR 1624.104 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 1624.104 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1624.104 Contract clause. Records retained by FEHBP carriers on...

48 CFR 1624.104 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 1624.104 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1624.104 Contract clause. Records retained by FEHBP carriers on...

48 CFR 1624.104 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 1624.104 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1624.104 Contract clause. Records retained by FEHBP carriers on...

Using vehicle-to-grid technology for frequency regulation and peak-load reduction

NASA Astrophysics Data System (ADS)

White, Corey D.; Zhang, K. Max

This paper explores the potential financial return for using plug-in hybrid electric vehicles as a grid resource. While there is little financial incentive for individuals when the vehicle-to-grid (V2G) service is used exclusively for peak reduction, there is a significant potential for financial return when the V2G service is used for frequency regulation. We propose that these two uses for V2G technology are not mutually exclusive, and that there could exist a "dual-use" program that utilizes V2G for multiple uses simultaneously. In our proposition, V2G could be used for regulation on a daily basis to ensure profits, and be used for peak reduction on days with high electricity demand and poor ambient air quality in order to reap the greatest environmental benefits. The profits for the individual in this type of dual-use program are close to or even higher than the profits experienced in either of the single-use programs. More importantly, we argue that the external benefits of this type of program are much greater as well. At higher V2G participation rates, our analysis shows that the market for regulation capacity could become saturated by V2G-based regulation providers. At the same time, there is plenty of potential for widespread use of V2G technology, especially if the demand for regulation, reserves, and storage grows as more intermittent renewable resources are being incorporated into the power systems.

34 CFR 403.92 - Under what circumstances may the age limit under the Sex Equity Program be waived?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Sex Equity Program be waived? 403.92 Section 403.92 Education Regulations of the Offices of the... the Basic Programs? Sex Equity Program § 403.92 Under what circumstances may the age limit under the Sex Equity Program be waived? The individual appointed under § 403.13(a) may waive the requirement in...

34 CFR 403.92 - Under what circumstances may the age limit under the Sex Equity Program be waived?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Sex Equity Program be waived? 403.92 Section 403.92 Education Regulations of the Offices of the... the Basic Programs? Sex Equity Program § 403.92 Under what circumstances may the age limit under the Sex Equity Program be waived? The individual appointed under § 403.13(a) may waive the requirement in...

34 CFR 403.92 - Under what circumstances may the age limit under the Sex Equity Program be waived?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Sex Equity Program be waived? 403.92 Section 403.92 Education Regulations of the Offices of the... the Basic Programs? Sex Equity Program § 403.92 Under what circumstances may the age limit under the Sex Equity Program be waived? The individual appointed under § 403.13(a) may waive the requirement in...

34 CFR 403.92 - Under what circumstances may the age limit under the Sex Equity Program be waived?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Sex Equity Program be waived? 403.92 Section 403.92 Education Regulations of the Offices of the... the Basic Programs? Sex Equity Program § 403.92 Under what circumstances may the age limit under the Sex Equity Program be waived? The individual appointed under § 403.13(a) may waive the requirement in...

34 CFR 403.92 - Under what circumstances may the age limit under the Sex Equity Program be waived?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Sex Equity Program be waived? 403.92 Section 403.92 Education Regulations of the Offices of the... the Basic Programs? Sex Equity Program § 403.92 Under what circumstances may the age limit under the Sex Equity Program be waived? The individual appointed under § 403.13(a) may waive the requirement in...

29 CFR 1960.71 - Agency annual reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... individual agency progress and problems in correcting unsafe or unhealthful working conditions, and... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) BASIC PROGRAM ELEMENTS FOR FEDERAL EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED...

34 CFR 611.41 - Under what circumstances may an individual receive a scholarship of program funds to attend a...

Code of Federal Regulations, 2010 CFR

2010-07-01

... scholarship of program funds to attend a teacher training program? 611.41 Section 611.41 Education Regulations..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.41 Under what... executing a binding agreement with the institution of higher education (IHE) offering the scholarship that...

34 CFR 611.41 - Under what circumstances may an individual receive a scholarship of program funds to attend a...

Code of Federal Regulations, 2011 CFR

2011-07-01

... scholarship of program funds to attend a teacher training program? 611.41 Section 611.41 Education Regulations..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.41 Under what... executing a binding agreement with the institution of higher education (IHE) offering the scholarship that...

Aviation--An Individualized Approach

ERIC Educational Resources Information Center

Seeds, Fred F.

1974-01-01

Describes an individualized aviation course for high school seniors. The course, broken down into Learner Education Guides with students progressing at their own learning rates, consists of the history of aviation, career opportunities, the space program, basic aeronautics, navigation, meteorology, Federal Aviation Administration regulations and…

34 CFR 403.14 - What are the personnel requirements regarding coordination with services for individuals with...

Code of Federal Regulations, 2011 CFR

2011-07-01

... part B of the Individuals with Disabilities Education Act (IDEA) (20 U.S.C. 1400 et seq.) to review the.... 794) and the IDEA and regulations implementing those statutes, regarding equal access to programs; and...

Emotional Skills-Building Curriculum

ERIC Educational Resources Information Center

Pickover, Sheri

2010-01-01

Current anger management programs use a cognitive behavior perspective; however, research also links anger control to developmental deficits such as attachment insecurity and emotional regulation. This article previews the Emotional Skills-Building Curriculum (ESBC), a 13-week treatment program designed to treat individuals who are referred for…

5 CFR 362.302 - Eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Eligibility. 362.302 Section 362.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Recent Graduates Program § 362.302 Eligibility. (a) A Recent Graduate is an individual who obtained a qualifying...

5 CFR 362.302 - Eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Eligibility. 362.302 Section 362.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Recent Graduates Program § 362.302 Eligibility. (a) A Recent Graduate is an individual who obtained a qualifying...

5 CFR 362.202 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Definitions. 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Internship Program § 362.202 Definitions. In this subpart: Student means an individual accepted for enrollment or...

5 CFR 362.202 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Internship Program § 362.202 Definitions. In this subpart: Student means an individual accepted for enrollment or...

7 CFR 247.8 - Individuals applying to participate in CSFP.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

7 CFR 247.8 - Individuals applying to participate in CSFP.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

7 CFR 247.8 - Individuals applying to participate in CSFP.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

7 CFR 247.8 - Individuals applying to participate in CSFP.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

17 CFR 200.24a - Director of the Office of Consumer Affairs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management... and administering a nationwide system for resolving investor complaints against individuals and... information to investors who inquire about individuals and entities regulated by the Commission, the operation...

48 CFR 903.104-1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 903.104-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL IMPROPER BUSINESS... program manager. Program manager means the individual within DOE who: (1) Exercises authority on a day-to...) Is generally the person at the lowest organizational level who has authority to make technical and...

24 CFR 200.610 - Policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It... condition in which individuals of similar income levels in the same housing market area have a like range of... programs shall pursue affirmative fair housing marketing policies in soliciting buyers and tenants, in...

49 CFR 1549.103 - Qualifications and training of individuals with security-related duties.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Circulars; and (4) The applicable portions of approved airport security program(s) and aircraft operator... security-related duties. 1549.103 Section 1549.103 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1548.11 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2013 CFR

2013-10-01

...; (2) Applicable Security Directives and Information Circulars; (3) The approved airport security... Directives and Information Circulars; (4) The approved airport security program(s) applicable to their... security-related duties. 1548.11 Section 1548.11 Transportation Other Regulations Relating to...

49 CFR 1544.235 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... airport security program applicable to their location, and the aircraft operator's security program to the... security-related duties. 1544.235 Section 1544.235 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1544.235 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... airport security program applicable to their location, and the aircraft operator's security program to the... security-related duties. 1544.235 Section 1544.235 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1548.11 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2014 CFR

2014-10-01

...; (2) Applicable Security Directives and Information Circulars; (3) The approved airport security... Directives and Information Circulars; (4) The approved airport security program(s) applicable to their... security-related duties. 1548.11 Section 1548.11 Transportation Other Regulations Relating to...

49 CFR 1544.235 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2012 CFR

2012-10-01

... airport security program applicable to their location, and the aircraft operator's security program to the... security-related duties. 1544.235 Section 1544.235 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1549.103 - Qualifications and training of individuals with security-related duties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Circulars; and (4) The applicable portions of approved airport security program(s) and aircraft operator... security-related duties. 1549.103 Section 1549.103 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1548.11 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2012 CFR

2012-10-01

...; (2) Applicable Security Directives and Information Circulars; (3) The approved airport security... Directives and Information Circulars; (4) The approved airport security program(s) applicable to their... security-related duties. 1548.11 Section 1548.11 Transportation Other Regulations Relating to...

49 CFR 1544.235 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2011 CFR

2011-10-01

... airport security program applicable to their location, and the aircraft operator's security program to the... security-related duties. 1544.235 Section 1544.235 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1549.103 - Qualifications and training of individuals with security-related duties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Circulars; and (4) The applicable portions of approved airport security program(s) and aircraft operator... security-related duties. 1549.103 Section 1549.103 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

49 CFR 1548.11 - Training and knowledge for individuals with security-related duties.

Code of Federal Regulations, 2011 CFR

2011-10-01

...; (2) Applicable Security Directives and Information Circulars; (3) The approved airport security... Directives and Information Circulars; (4) The approved airport security program(s) applicable to their... security-related duties. 1548.11 Section 1548.11 Transportation Other Regulations Relating to...

34 CFR 664.3 - Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad...

Code of Federal Regulations, 2014 CFR

2014-07-01

... the Fulbright-Hays Group Projects Abroad Program? 664.3 Section 664.3 Education Regulations of the... EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM General § 664.3 Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad Program? An individual is eligible to...

34 CFR 664.3 - Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad...

Code of Federal Regulations, 2012 CFR

2012-07-01

... the Fulbright-Hays Group Projects Abroad Program? 664.3 Section 664.3 Education Regulations of the... EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM General § 664.3 Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad Program? An individual is eligible to...

34 CFR 664.3 - Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad...

Code of Federal Regulations, 2013 CFR

2013-07-01

... the Fulbright-Hays Group Projects Abroad Program? 664.3 Section 664.3 Education Regulations of the... EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM General § 664.3 Who is eligible to participate in projects funded under the Fulbright-Hays Group Projects Abroad Program? An individual is eligible to...

13 CFR 112.12 - Effect on other regulations; forms and instructions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... regulations, orders or like directions heretofore issued by SBA which impose requirements designed to prohibit any discrimination against individuals on the grounds of race, color, or national origin and which... the grounds of race, color, or national origin in any program or situation to which this part is...

18 CFR 1302.12 - Effect on other regulations; supervision and coordination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... which impose requirements designed to prohibit any discrimination against individuals on the ground of race, color, or national origin to which this regulation applies, and which authorize the suspension or..., insofar as they prohibit discrimination on the ground of race, color, or national origin in any program or...

6 CFR 21.21 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... NONDISCRIMINATION ON THE BASIS OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... designed to prohibit any discrimination against individuals on the grounds of race, color, or national..., insofar as such orders, regulations, or instructions prohibit discrimination on the ground of race, color...

6 CFR 21.21 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... NONDISCRIMINATION ON THE BASIS OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... designed to prohibit any discrimination against individuals on the grounds of race, color, or national..., insofar as such orders, regulations, or instructions prohibit discrimination on the ground of race, color...

6 CFR 21.21 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... NONDISCRIMINATION ON THE BASIS OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... designed to prohibit any discrimination against individuals on the grounds of race, color, or national..., insofar as such orders, regulations, or instructions prohibit discrimination on the ground of race, color...

6 CFR 21.21 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... NONDISCRIMINATION ON THE BASIS OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... designed to prohibit any discrimination against individuals on the grounds of race, color, or national..., insofar as such orders, regulations, or instructions prohibit discrimination on the ground of race, color...

6 CFR 21.21 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... NONDISCRIMINATION ON THE BASIS OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... designed to prohibit any discrimination against individuals on the grounds of race, color, or national..., insofar as such orders, regulations, or instructions prohibit discrimination on the ground of race, color...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2012 CFR

2012-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2014 CFR

2014-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2011 CFR

2011-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2013 CFR

2013-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

77 FR 46658 - Proposed Priority; Technical Assistance To Improve State Data Capacity-National Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... percent of youth with individualized education programs (IEPs) graduating with a regular high school... 100,000 schools through EDFacts. \\4\\ Education Department General Administrative Regulations (EDGAR... Department programs (e.g., Consolidated State Performance Report under the Elementary and Secondary Education...

Legal IEPs: A Common Sense Approach with Barbara Bateman. [Videotape].

ERIC Educational Resources Information Center

Council for Exceptional Children, Reston, VA. Div. for Learning Disabilities.

In this 2-hour videotape workshop designed for teachers, administrators, parents, and others, Dr. Barbara Bateman answers many key questions that have been raised about Individualized Education Programs (IEPs) since the 1997 amendments to the Individuals with Disabilities Education Act (IDEA) and the 1999 regulations. The videotape reviews the…

40 CFR 141.571 - What records does subpart T require my system to keep?

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and... necessary records Duration of time records must be kept (a) Individual Filter Turbidity Requirements(§§ 141.560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling...

40 CFR 141.571 - What records does subpart T require my system to keep?

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and... necessary records Duration of time records must be kept (a) Individual Filter Turbidity Requirements(§§ 141.560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling...

40 CFR 141.571 - What records does subpart T require my system to keep?

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and... necessary records Duration of time records must be kept (a) Individual Filter Turbidity Requirements(§§ 141.560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling...

40 CFR 141.571 - What records does subpart T require my system to keep?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and... necessary records Duration of time records must be kept (a) Individual Filter Turbidity Requirements(§§ 141.560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling...

45 CFR 2516.860 - Will information on individual participants be kept confidential?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Will information on individual participants be kept confidential? 2516.860 Section 2516.860 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Evaluation...

45 CFR 261.14 - What is the penalty if an individual refuses to engage in work?

Code of Federal Regulations, 2010 CFR

2010-10-01

... engage in work? 261.14 Section 261.14 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the Provisions Addressing Individual...

45 CFR 2516.860 - Will information on individual participants be kept confidential?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Will information on individual participants be kept confidential? 2516.860 Section 2516.860 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Evaluation...

34 CFR 356.3 - What regulations apply to this program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... purposefully requires inclusion of children with disabilities or individuals with mental disabilities as... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION...

78 FR 49367 - Regulations Pertaining to the Disclosure of Return Information To Carry Out Eligibility...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... Health Insurance Affordability Programs AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final..., a State's children's health insurance program under title XXI of the Social Security Act (CHIP), or... each individual whose income is relevant to the determination of eligibility for health insurance...

34 CFR 535.1 - What is the Bilingual Education: Graduate Fellowship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... institutions of higher education (IHEs), to individuals who are pursuing master's, doctoral, or post-doctoral... Program? 535.1 Section 535.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF BILINGUAL EDUCATION AND MINORITY LANGUAGES AFFAIRS, DEPARTMENT OF EDUCATION BILINGUAL...

34 CFR 535.1 - What is the Bilingual Education: Graduate Fellowship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... institutions of higher education (IHEs), to individuals who are pursuing master's, doctoral, or post-doctoral... Program? 535.1 Section 535.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF BILINGUAL EDUCATION AND MINORITY LANGUAGES AFFAIRS, DEPARTMENT OF EDUCATION BILINGUAL...

34 CFR 105.32 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 105.32 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... entirety, is readily accessible to and usable by individuals with handicaps. This paragraph does not— (1...

34 CFR 105.32 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 105.32 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... entirety, is readily accessible to and usable by individuals with handicaps. This paragraph does not— (1...

34 CFR 350.22 - What activities must a Rehabilitation Research and Training Center conduct?

Code of Federal Regulations, 2013 CFR

2013-07-01

... individuals with disabilities, through conferences, workshops, public education programs, in-service training... Training Center conduct? 350.22 Section 350.22 Education Regulations of the Offices of the Department of... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Research and Training...

34 CFR 350.22 - What activities must a Rehabilitation Research and Training Center conduct?

Code of Federal Regulations, 2011 CFR

2011-07-01

... individuals with disabilities, through conferences, workshops, public education programs, in-service training... Training Center conduct? 350.22 Section 350.22 Education Regulations of the Offices of the Department of... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Research and Training...

34 CFR 350.22 - What activities must a Rehabilitation Research and Training Center conduct?

Code of Federal Regulations, 2012 CFR

2012-07-01

... individuals with disabilities, through conferences, workshops, public education programs, in-service training... Training Center conduct? 350.22 Section 350.22 Education Regulations of the Offices of the Department of... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Research and Training...

34 CFR 350.22 - What activities must a Rehabilitation Research and Training Center conduct?

Code of Federal Regulations, 2014 CFR

2014-07-01

... individuals with disabilities, through conferences, workshops, public education programs, in-service training... Training Center conduct? 350.22 Section 350.22 Education Regulations of the Offices of the Department of... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Research and Training...

USDA - Forest Service Termiticide Report for 2013

Treesearch

Thomas Shelton; Donald Fye; Michael Ulyshen

2014-01-01

The USDA-FS Termiticde Testing Program has been evaluating termiticide performance since the 1930s. The program has provided baseline performance data for all termiticdes currently registered in the U.S. Through this report and individual product reports, registered termiticide performance data has been provided to pesticide manufacturers, regulators, the pest...

Department of Defense Dependents Schools Special Education Dispute Management System.

ERIC Educational Resources Information Center

Dependents Schools (DOD), Washington, DC.

The regulations outline procedures and policies for resolving disputes in special education in the U.S. Department of Defense Dependents schools. Processes involved in conferences, mediation, and due process hearings concerning issues of identification, eligibility, individualized education programs, or programing are outlined. At each of the…

Combating Discrimination in the Schools: Legal Remedies and Guidelines.

ERIC Educational Resources Information Center

National Education Association, Washington, DC.

This booklet outlines the Federal laws and regulations prohibiting discrimination in educational institutions and programs. It is not a comprehensive listing of all antidiscrimination laws, but rather a guide to laws and regulations that may be used for individual and group action. The primary emphasis in this pamphlet is on the protection of…

Resident duty hours: a survey of internal medicine program directors.

PubMed

Garg, Megha; Drolet, Brian C; Tammaro, Dominick; Fischer, Staci A

2014-10-01

In 2011, the Accreditation Council for Graduate Medical Education (ACGME) implemented new Common Program Requirements to regulate duty hours of resident physicians, with three goals: improved patient safety, quality of resident education and quality of life for trainees. We sought to assess Internal Medicine program director (IMPD) perceptions of the 2011 Common Program Requirements in July 2012, one year following implementation of the new standards. A cross-sectional study of all IMPDs at ACGME-accredited programs in the United States (N = 381) was performed using a 32-question, self-administered survey. Contact information was identified for 323 IMPDs. Three individualized emails were sent to each director over a 6-week period, requesting participation in the survey. Outcomes measured included approval of duty hours regulations, as well as perceptions of changes in graduate medical education and patient care resulting from the revised ACGME standards. A total of 237 surveys were returned (73% response rate). More than half of the IMPDs (52%) reported "overall" approval of the 2011 duty hour regulations, with greater than 70% approval of all individual regulations except senior resident daily duty periods (49% approval) and 16-hour intern shifts (17% approval). Although a majority feel resident quality of life has improved (55%), most IMPDs believe that resident education (60%) is worse. A minority report that quality (8%) or safety (11%) of patient care has improved. One year after implementation of new ACGME duty hour requirements, IMPDs report overall approval of the standards, but strong disapproval of 16-hour shift limits for interns. Few program directors perceive that the duty hour restrictions have resulted in better care for patients or education of residents. Although resident quality of life seems improved, most IMPDs report that their own workload has increased. Based on these results, the intended benefits of duty hour regulations may not yet have been realized.

41 CFR 128-1.8004 - Seismic Safety Coordinators.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Regulations System (Continued) DEPARTMENT OF JUSTICE 1-INTRODUCTION 1.80-Seismic Safety Program... individual with technical training, engineering experience and a seismic background as the Department of...

34 CFR 1100.11 - How does an individual apply for a fellowship?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How does an individual apply for a fellowship? 1100.11 Section 1100.11 Education Regulations of the Offices of the Department of Education (Continued) NATIONAL INSTITUTE FOR LITERACY NATIONAL INSTITUTE FOR LITERACY: LITERACY LEADER FELLOWSHIP PROGRAM How Does an...

Self-regulated learning in a dynamic coaching model for supporting college students with traumatic brain injury: two case reports.

PubMed

Kennedy, Mary R T; Krause, Miriam O

2011-01-01

To describe a program that integrates self-regulated learning theory with supported education for college students with traumatic brain injury using a dynamic coaching model; to demonstrate the feasibility of developing and implementing such a program; and to identify individualized outcomes. Case study comparisons. University setting. Two severely injured students with cognitive impairments. A dynamic coaching model of supported education which incorporated self-regulated learning was provided for students with traumatic brain injury while attending college. Outcomes were both short and long term including decontextualized standardized test scores, self-reported academic challenges, number and specificity of reported strategies, grades on assignments, number of credits completed versus attempted, and changes in academic status and campus life. Students improved on graded assignments after strategy instruction and reported using more strategies by the end of the year. Students completed most of the credits they attempted, were in good academic standing, and made positive academic decisions. Performance on decontextualized tests pre- and postintervention was variable. It is feasible to deliver a hybrid supported education program that is dynamically responsive to individual students' needs and learning styles. Reasons for including both functional and standardized test outcomes are discussed.

Programming of the appetite-regulating neural network: a link between maternal overnutrition and the programming of obesity?

PubMed

Mühlhäusler, B S

2007-01-01

The concept of a functional foetal "appetite regulatory neural network" is a new and potentially critical one. There is a growing body of evidence showing that the nutritional environment to which the foetus is exposed during prenatal and perinatal development has long-term consequences for the function of the appetite-regulating neural network and therefore the way in which an individual regulates energy balance throughout later life. This is of particular importance in the context of evidence obtained from a wide range of epidemiological studies, which have shown that individuals exposed to an elevated nutrient supply before birth have an increased risk of becoming obese as children and adults. This review summarises the key pieces of experimental evidence, by our group and others, that have contributed to our current understanding of the programming of appetite, and highlights the important questions that are yet to be answered. It is clear that this area of research has the potential to generate, within the next few years, interventions that could begin to alleviate the adverse long-term consequences of being exposed to an elevated nutrient supply before birth.

Chemical Waste Management for the Conditionally Exempt Small Quantity Generator

NASA Astrophysics Data System (ADS)

Zimmer, Steven W.

1999-06-01

Management of hazardous chemical wastes generated as a part of the curriculum poses a significant task for the individual responsible for maintaining compliance with all rules and regulations from the Environmental Protection Agency and the Department of Transportation while maintaining the principles of OSHA's Lab Standard and the Hazard Communication Standard. For schools that generate relatively small quantities of waste, an individual can effectively manage the waste program without becoming overly burdened by the EPA regulations required for those generating large quantities of waste, if given the necessary support from the institution.

34 CFR 79.3 - What programs and activities of the Department are subject to these regulations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Metropolitan Development Act. (b) If a program or activity of the Department that provides Federal financial.... (5) Direct payments to individuals. (6) Financial transfers for which the Department has no funding... the Education Consolidation and Improvement Act of 1981). (7) Research and development national in...

7 CFR 1405.1 - Interest.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Except as may otherwise be determined by CCC as provided in individual program regulations, program contracts or such other means as deemed appropriate by CCC the rate of interest that is applicable to CCC loans shall be equal to the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on...

7 CFR 1405.1 - Interest.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Except as may otherwise be determined by CCC as provided in individual program regulations, program contracts or such other means as deemed appropriate by CCC the rate of interest that is applicable to CCC loans shall be equal to the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on...

7 CFR 1405.1 - Interest.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Except as may otherwise be determined by CCC as provided in individual program regulations, program contracts or such other means as deemed appropriate by CCC the rate of interest that is applicable to CCC loans shall be equal to the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on...

7 CFR 1405.1 - Interest.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Except as may otherwise be determined by CCC as provided in individual program regulations, program contracts or such other means as deemed appropriate by CCC the rate of interest that is applicable to CCC loans shall be equal to the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on...

7 CFR 1405.1 - Interest.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Except as may otherwise be determined by CCC as provided in individual program regulations, program contracts or such other means as deemed appropriate by CCC the rate of interest that is applicable to CCC loans shall be equal to the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on...

Regulations Governing Special Education Programs for Children with Disabilities in Virginia (Effective January 1994).

ERIC Educational Resources Information Center

Virginia State Dept. of Education, Richmond. Div. of Compliance Coordination.

The Virginia regulations for special education have been designed to comply with the Individuals with Disabilities Education Act, Section 504 of the Rehabilitation Act of 1973, the Americans with Disabilities Act, and the Virginians with Disabilities Act. Part 1 presents definitions of 80 terms. Part 2 considers responsibilities and functions of…

Medicare program; offset of Medicare payments to individuals to collect past-due obligations arising from breach of scholarship and loan contracts--HCFA. Final rule.

PubMed

1992-05-04

This final rule sets forth the procedures to be followed for collection of past-due amounts owed by individuals who breached contracts under certain scholarship and loan programs. The programs that would be affected are the National Health Service Corps Scholarship, the Physician Shortage Area Scholarship, and the Health Education Assistance Loan. These procedures would apply to those individuals who breached contracts under the scholarship and loan programs and who-- Accept Medicare assignment for services; Are employed by or affiliated with a provider, Health Maintenance Organization, or Competitive Medical Plan that receives Medicare payment for services; or Are members of a group practice that receives Medicare payment for services. This regulation implements section 1892 of the Social Security Act, as added by section 4052 of the Omnibus Budget Reconciliation Act of 1987.

40 CFR 5.210 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... regulations do not apply to an educational institution whose primary purpose is the training of individuals...

31 CFR 28.210 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Treasury NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... regulations do not apply to an educational institution whose primary purpose is the training of individuals...

31 CFR 28.210 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Treasury NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... regulations do not apply to an educational institution whose primary purpose is the training of individuals...

40 CFR 141.561 - What happens if my system's turbidity monitoring equipment fails?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer Than 10,000 People Individual Filter Turbidity Requirements § 141.561 What...

76 FR 16231 - Clarification of Countries and Geographic Areas Eligible for Participation in the Guam...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... regulations to clarify that individuals holding British National (Overseas) (BN(O)) passports as a result of... days. This interim final rule provides that beginning May 23, 2011, individuals holding BN(O) passports...-CNMI Visa Waiver Program on such BN(O) passport must present it and a Hong Kong identification card...

Family matters: Intergenerational and interpersonal processes of executive function and attentive behavior

PubMed Central

Deater-Deckard, Kirby

2014-01-01

Individual differences in self-regulation include executive function (EF) components that serve self-regulation of attentive behavior by modulating reactive responses to the environment. These factors “run in families”. The purpose of this review is to summarize a program of research that addresses familial inter-generational transmission and inter-personal processes in development. Self-regulation of attentive behavior involves inter-related aspects of executive function (EF) including attention, inhibitory control, and working memory. Individual differences in EF skills develop in systematic ways over childhood, resulting in moderately stable differences between people by early adolescence. Through complex gene-environment transactions, EF is transmitted across generations within parent-child relationships that provide powerful socialization and experiential contexts in which EF and related attentive behavior are forged and practiced. Families matter as parents regulate home environments and themselves as best they can while also supporting cognitive self-regulation of attentive behavior in their children. PMID:25197171

75 FR 1685 - HOPE for Homeowners Program; Statutory Transfer of Program Authority to HUD and Conforming...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-12

... by calling the Regulations Division at 202-708-3055 (this is not a toll-free number). Individuals with speech or hearing impairments may access this number through TTY by calling the toll-free Federal... a toll-free number). Persons with hearing or speech impairments may access this number through TTY...

A Self-Regulated Learning Program for High-Ability Individuals, Using On-Line Tools

ERIC Educational Resources Information Center

Jorge, Carmen M. Hernandez; Borges del Rosal, Africa

2005-01-01

Possessing high intellectual ability is no guarantee of academic success. In fact, the relevant literature often reports problems of delays in academic progress, as well as hyperactivity and attention problems in students of high ability. It is therefore relevant to design programs which help toward attainment of academic success. In this paper we…

78 FR 12655 - Federal-State Unemployment Insurance (UI) Program; Data Exchange Standardization as Required by...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... of individuals who have participated in workforce investment programs in SWAs; The UI Inquiry data... modules to be developed and direct these funds to NASWA for the development of these modules. All SWAs... Maryland Department of Labor, Licensing and Regulation acts as the Department's agent to contract with a...

34 CFR 403.81 - How must funds be used under the Single Parents, Displaced Homemakers, and Single Pregnant Women...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Displaced Homemakers, and Single Pregnant Women Program? 403.81 Section 403.81 Education Regulations of the... Secretary Assist Under the Basic Programs? Single Parents, Displaced Homemakers, and Single Pregnant Women... individuals who are single parents, displaced homemakers, or single pregnant women only to— (a) Provide...

"The solution needs to be complex." Obese adults' attitudes about the effectiveness of individual and population based interventions for obesity

PubMed Central

2010-01-01

Background Previous studies of public perceptions of obesity interventions have been quantitative and based on general population surveys. This study aims to explore the opinions and attitudes of obese individuals towards population and individual interventions for obesity in Australia. Methods Qualitative methods using in-depth semi-structured telephone interviews with a community sample of obese adults (Body Mass Index ≥30). Theoretical, purposive and strategic recruitment techniques were used to ensure a broad sample of obese individuals with different types of experiences with their obesity. Participants were asked about their attitudes towards three population based interventions (regulation, media campaigns, and public health initiatives) and three individual interventions (tailored fitness programs, commercial dieting, and gastric banding surgery), and the effectiveness of these interventions. Results One hundred and forty two individuals (19-75 years) were interviewed. Participants strongly supported non-commercial interventions that were focused on encouraging individuals to make healthy lifestyle changes (regulation, physical activity programs, and public health initiatives). There was less support for interventions perceived to be invasive or high risk (gastric band surgery), stigmatising (media campaigns), or commercially motivated and promoting weight loss techniques (commercial diets and gastric banding surgery). Conclusion Obese adults support non-commercial, non-stigmatising interventions which are designed to improve lifestyles, rather than promote weight loss. PMID:20633250

5 CFR 900.412 - Effect on other regulations, forms, and instructions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requirements designed to prohibit discrimination against individuals on the ground of race, color, or national... instructions prohibit discrimination on the ground of race, color, or national origin in a program or situation...

Effectiveness of a self-regulated remedial program for handwriting difficulties.

PubMed

Van Waelvelde, Hilde; De Roubaix, Amy; Steppe, Lien; Troubleyn, Evy; De Mey, Barbara; Dewitte, Griet; Debrabant, Julie; Van de Velde, Dominique

2017-09-01

Handwriting difficulties may have pervasive effects on a child's school performance. I Can! is a remedial handwriting program with a focus on self-regulated learning and applying motor learning principles combined with a behavioural approach. It is developed for typically developing children with handwriting problems. The study aim was to evaluate the program's effectiveness. Thirty-one children aged 7-8 year participated in a cross-over study. Handwriting quality and speed were repeatedly assessed by means of the Systematic Screening of Handwriting Difficulties test. Difficulties addressed were fluency in letter formation, fluency in letter connections, letter height, regularity of letter height, space between words, and line path. Mixed model analysis revealed improved quality of writing and speed for all children but significantly more improvement in handwriting quality for the children participating in the program. Although writing speed improved over time, no additional effects of the program occurred. 'I Can!' is found to be an effective instructive program to ameliorate handwriting quality in typically developing children with handwriting difficulties. The program's success was by a therapy burst of only 7 weeks focusing on the child's self-regulated learning capacities, within an individualized education plan according to their needs and goals.

34 CFR 364.59 - May an individual's ability to pay be considered in determining his or her participation in the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION STATE INDEPENDENT LIVING SERVICES PROGRAM AND CENTERS FOR... 34 Education 2 2011-07-01 2010-07-01 true May an individual's ability to pay be considered in determining his or her participation in the costs of IL services? 364.59 Section 364.59 Education Regulations...

34 CFR 364.59 - May an individual's ability to pay be considered in determining his or her participation in the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION STATE INDEPENDENT LIVING SERVICES PROGRAM AND CENTERS FOR... 34 Education 2 2010-07-01 2010-07-01 false May an individual's ability to pay be considered in determining his or her participation in the costs of IL services? 364.59 Section 364.59 Education Regulations...

20 CFR 660.300 - What definitions apply to the regulations for workforce investment systems under title I of WIA?

Code of Federal Regulations, 2011 CFR

2011-04-01

... or more organized labor unions for the purpose of mutual support and action. Literacy means an... information to determine an individual's eligibility for services under WIA title I. Individuals may be... the information he/she submits to demonstrate eligibility for a program under title I of WIA is true...

7 CFR 3430.16 - Eligibility requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE COMPETITIVE AND NONCOMPETITIVE NON-FORMULA FEDERAL ASSISTANCE PROGRAMS-GENERAL AWARD... to individuals. Unless otherwise specified, only United States citizens, non-citizen nationals of the...

45 CFR 1301.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... provides ongoing comprehensive child development services. Independent auditor means an individual... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1301.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... provides ongoing comprehensive child development services. Independent auditor means an individual... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1311.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... individuals working in the field of child development and family services. ... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1311.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... individuals working in the field of child development and family services. ... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1311.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... individuals working in the field of child development and family services. ... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1301.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... provides ongoing comprehensive child development services. Independent auditor means an individual... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START...

45 CFR 1311.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START... individuals working in the field of child development and family services. ...

45 CFR 1311.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START... individuals working in the field of child development and family services. ...

An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis.

PubMed

Walsh, Logan A; Alvarez, Mariano J; Sabio, Erich Y; Reyngold, Marsha; Makarov, Vladimir; Mukherjee, Suranjit; Lee, Ken-Wing; Desrichard, Alexis; Turcan, Şevin; Dalin, Martin G; Rajasekhar, Vinagolu K; Chen, Shuibing; Vahdat, Linda T; Califano, Andrea; Chan, Timothy A

2017-08-15

At the root of most fatal malignancies are aberrantly activated transcriptional networks that drive metastatic dissemination. Although individual metastasis-associated genes have been described, the complex regulatory networks presiding over the initiation and maintenance of metastatic tumors are still poorly understood. There is untapped value in identifying therapeutic targets that broadly govern coordinated transcriptional modules dictating metastatic progression. Here, we reverse engineered and interrogated a breast cancer-specific transcriptional interaction network (interactome) to define transcriptional control structures causally responsible for regulating genetic programs underlying breast cancer metastasis in individual patients. Our analyses confirmed established pro-metastatic transcription factors, and they uncovered TRIM25 as a key regulator of metastasis-related transcriptional programs. Further, in vivo analyses established TRIM25 as a potent regulator of metastatic disease and poor survival outcome. Our findings suggest that identifying and targeting keystone proteins, like TRIM25, can effectively collapse transcriptional hierarchies necessary for metastasis formation, thus representing an innovative cancer intervention strategy. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Implementing HIPAA security in a membership organization.

PubMed

Hillabrant, L P; Gaignard, K E

2000-01-01

The upcoming HIPAA security regulations are forcing a change in business and operating procedures that many, if not most, healthcare organizations are ill-prepared to tackle. Of all healthcare organizational structures, membership organizations will most likely face the greatest number of obstacles in preparing for and implementing the HIPAA security regulations. This is because the membership organization as a whole must find a way to accommodate the disparate technologies, business and operating methodologies and processes, and available, limited resources of its individual member organizations, and integrate these into a uniform implementation plan. Compounding these obvious difficulties is the unique challenge of enforcement authority. The individual member organizations are autonomous business entities, whereas the membership organization as a whole merely acts as an advisor or consultant, and has only limited enforcement authority over any individual member organization. This article explores this unique situation in depth. We focus on PROMINA Health System, a nonprofit healthcare membership organization that consists of five disparate member healthcare organizations. We examine the challenges PROMINA has encountered in its quest to institute an organization-wide HIPAA security program and its methodology for accomplishing program implementation.

5 CFR 890.1303 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL... Demonstration Project § 890.1303 Eligibility. (a) To enroll in the demonstration project, an individual must... benefit plans offered through the FEHB Program under the demonstration project. (d) When determining...

45 CFR 2490.140 - Employment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.140 Employment. No qualified individual with handicaps shall...

45 CFR 2490.140 - Employment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.140 Employment. No qualified individual with handicaps shall...

45 CFR 2490.140 - Employment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.140 Employment. No qualified individual with handicaps shall...

45 CFR 2490.140 - Employment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.140 Employment. No qualified individual with handicaps shall...

34 CFR 300.326 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational... 34 Education 2 2010-07-01 2010-07-01 false [Reserved] 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND...

34 CFR 300.303 - Reevaluations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational... 34 Education 2 2010-07-01 2010-07-01 false Reevaluations. 300.303 Section 300.303 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND...

Yeast as a model to study apoptosis?

PubMed

Fleury, Christophe; Pampin, Mathieu; Tarze, Agathe; Mignotte, Bernard

2002-02-01

Programmed cell death (PCD) serves as a major mechanism for the precise regulation of cell numbers, and as a defense mechanism to remove unwanted and potentially dangerous cells. Despite the striking heterogeneity of cell death induction pathways, the execution of the death program is often associated with characteristic morphological and biochemical changes termed apoptosis. Although for a long time the absence of mitochondrial changes was considered as a hallmark of apoptosis, mitochondria appear today as the central executioner of programmed cell death. This crucial position of mitochondria in programmed cell death control is not due to a simple loss of function (deficit in energy supplying), but rather to an active process in the regulation of effector mechanisms. The large diversity of regulators of apoptosis in mammals and their numerous interactions complicate the analysis of their individual functions. Yeast, eukaryotic but unicellular organism, lack the main regulators of apoptosis (caspases, Bcl-2 family members, ...) found in mammals. This absence render them a powerful tool for heterologous expression, functional studies, and even cloning of new regulators of apoptosis. Great advances have thus been made in our understanding of the molecular mechanisms of Bcl-2 family members interactions with themselves and other cellular proteins, specially thanks to the two hybrid system and the easy manipulation of yeast (molecular biology and genetics). This review will focus on the use of yeast as a tool to identify new regulators and study function of mammalian apoptosis regulators.

45 CFR 261.60 - What hours of participation may a State report for a work-eligible individual?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true What hours of participation may a State report for a work-eligible individual? 261.60 Section 261.60 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THA...

Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake?

PubMed

Zhu, Shaoyu; Eclarinal, Jesse; Baker, Maria S; Li, Ge; Waterland, Robert A

2016-02-01

Extensive human and animal model data show that environmental influences during critical periods of prenatal and early postnatal development can cause persistent alterations in energy balance regulation. Although a potentially important factor in the worldwide obesity epidemic, the fundamental mechanisms underlying such developmental programming of energy balance are poorly understood, limiting our ability to intervene. Most studies of developmental programming of energy balance have focused on persistent alterations in the regulation of energy intake; energy expenditure has been relatively underemphasised. In particular, very few studies have evaluated developmental programming of physical activity. The aim of this review is to summarise recent evidence that early environment may have a profound impact on establishment of individual propensity for physical activity. Recently, we characterised two different mouse models of developmental programming of obesity; one models fetal growth restriction followed by catch-up growth, and the other models early postnatal overnutrition. In both studies, we observed alterations in body-weight regulation that persisted to adulthood, but no group differences in food intake. Rather, in both cases, programming of energy balance appeared to be due to persistent alterations in energy expenditure and spontaneous physical activity (SPA). These effects were stronger in female offspring. We are currently exploring the hypothesis that developmental programming of SPA occurs via induced sex-specific alterations in epigenetic regulation in the hypothalamus and other regions of the central nervous system. We will summarise the current progress towards testing this hypothesis. Early environmental influences on establishment of physical activity are likely an important factor in developmental programming of energy balance. Understanding the fundamental underlying mechanisms in appropriate animal models will help determine whether early life interventions may be a practical approach to promote physical activity in man.

48 CFR 701.601 - General

Code of Federal Regulations, 2011 CFR

2011-10-01

... 701.601 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL... appropriate for their programs and activities, subject to government-wide and USAID requirements and... any time. May issue warrants for simplified acquisitions up to $50,000 to qualified individuals on his...

48 CFR 701.601 - General

Code of Federal Regulations, 2014 CFR

2014-10-01

... 701.601 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL... appropriate for their programs and activities, subject to government-wide and USAID requirements and... any time. May issue warrants for simplified acquisitions up to $50,000 to qualified individuals on his...

5 CFR 370.108 - Reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 370.108 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS INFORMATION TECHNOLOGY EXCHANGE PROGRAM § 370.108 Reporting requirements. (a) Agencies using this part must prepare and... objectives of the individual's detail; and (3) Such other information as OPM considers appropriate. (b...

Strategies for Implementing a Standee-on-Lift Program for Fixed-Route Bus Service

DOT National Transportation Integrated Search

1993-06-01

The Americans with Disabilities Act (ADA) refers to individuals who use canes or walkers, or who have trouble climbing steps, as standees. The Department of Transportation regulations implementing the ADA require that transit properties allow standee...

29 CFR 1949.1 - Policy regarding tuition fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OFFICE OF TRAINING AND EDUCATION, OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION OSHA Training... safety and health program. Individuals or organizations wishing to be considered for this exemption shall...

29 CFR 1949.1 - Policy regarding tuition fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OFFICE OF TRAINING AND EDUCATION, OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION OSHA Training... safety and health program. Individuals or organizations wishing to be considered for this exemption shall...

34 CFR 300.327 - Educational placements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CHILDREN WITH DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and... 34 Education 2 2010-07-01 2010-07-01 false Educational placements. 300.327 Section 300.327 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION...

34 CFR 300.301 - Initial evaluations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Initial evaluations. 300.301 Section 300.301 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational...

48 CFR 2124.102-70 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 2124.102-70 Policy. Records retained by FEGLI... OPM. Consequently, the records do not fall within the provisions of the Privacy Act. Nevertheless, OPM...

7 CFR 1901.254 - Scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE PROGRAM REGULATIONS... buildings, schools, transportation, traffic, and law enforcement. (5) Loans to develop community irrigation..., development, and operation of farms and ranches. (2) Loans to individual families in rural areas for the...

7 CFR 1901.254 - Scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE PROGRAM REGULATIONS... buildings, schools, transportation, traffic, and law enforcement. (5) Loans to develop community irrigation..., development, and operation of farms and ranches. (2) Loans to individual families in rural areas for the...

Maryland's efforts to develop regulations creating an air emissions offset trading program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guy, D.M.; Zaw-Mon, M.

1999-07-01

Under the federal Clean Air Act's New Source Review program, many companies located in or planning to locate in areas that do not meet federal air quality standards or in the Northeast Ozone Transport Region (northern Virginia to Maine) must obtain emission reductions (called offsets) of volatile organic compounds and nitrogen oxides that are greater than the new emissions that will be released. This offset requirement allows growth in industry while protecting air quality against deterioration. Despite the federal offset requirement, a formal banking and trading program is not mandated by the Clean Air Act Amendments of 1990. Still, amore » mechanism is needed to ensure that emission reduction credits (ERCs) are available for sources to use to meet the offset requirement. Currently, Maryland does not have regulations covering the sale or transfer of ERCs from one facility to another. Maryland works with industry on a case-by-case basis to identify potential sources of ERCs and to assist in obtaining them. Then, the offset requirement and the ERCs used to meet the offsets are incorporated into individual permits using various permitting mechanisms. Desiring certainty and stability in the banking and trading process, Maryland's business community has pressed for regulations to formalize Maryland's procedures. Working over several years through a stakeholder process, Maryland has developed concepts for a trading program and a draft regulation. This paper describes Maryland's current case-by-case banking and trading procedure and traces efforts to develop a regulation to formalize the process. The paper discusses complex policy issues related to establishing a banking and trading program, describes the principal elements of Maryland's draft regulation, and summarizes elements of other states' emissions banking and trading programs.« less

European Long-Term Care Programs: Lessons for Community Living Assistance Services and Supports?

PubMed Central

Nadash, Pamela; Doty, Pamela; Mahoney, Kevin J; von Schwanenflugel, Matthias

2012-01-01

Objective To uncover lessons from abroad for Community Living Assistance Services and Supports (CLASS), a federally run voluntary public long-term care (LTC) insurance program created under the Accountable Care Act of 2010. Data Sources Program administrators and policy researchers from Austria, England, France, Germany, and the Netherlands. Study Design Qualitative methods focused on key parameters of cash for care: how programs set benefit levels; project expenditures; control administrative costs; regulate the use of benefits; and protect workers. Data Collection/Extraction Methods Structured discussions were conducted during an international conference of LTC experts, followed by personal meetings and individual correspondence. Principal Findings Germany's self-financing mandate and tight targeting of benefits have resulted in a solvent program with low premiums. Black markets for care are likely in the absence of regulation; France addresses this via a unique system ensuing legal payment of workers. Conclusions Programs in the five countries studied have lessons, both positive and negative, relevant to CLASS design. PMID:22091672

Providers perspectives on self-regulation impact their use of responsive feeding practices in child care.

PubMed

Dev, Dipti A; Speirs, Katherine E; Williams, Natalie A; Ramsay, Samantha; McBride, Brent A; Hatton-Bowers, Holly

2017-11-01

Supporting children's self-regulation in eating through caregivers' practice of responsive feeding is paramount to obesity prevention, and while much attention has been given to supporting children's self-regulation in eating through parents' responsive feeding practices in the home setting, little attention has been given to this issue in childcare settings. This qualitative study examines childcare providers' perspectives on using responsive feeding practices with young children (2-5years). Individual semi-structured interviews were conducted with providers until saturation was reached. Data was analyzed using thematic analysis. The final sample included 18 providers who were employed full-time in Head Start or state-licensed center-based childcare programs, cared for children (2-5y), and were directly responsible for serving meals and snacks. Providers were primarily (67%) employed in childcare programs that served children from low-income families and received reimbursement for meals and snacks from the US Department of Agriculture's Child and Adult Care Food Program. Three factors emerged that shaped childcare providers' experiences using responsive feeding practices: the providers' perspectives about whether or not young children can self-regulate food intake, their understanding of Child and Adult Care Food Program (CACFP) portion size regulations, and the availability of food at the center where they worked. Future research should examine how childcare providers' understanding of children's ability to self-regulate their food intake, the appropriate use of the CACFP regulations in relationship to serving sizes, and having food available to offer seconds promotes providers' use of responsive feeding practices in center-based childcare programs and children's dietary behaviors. Copyright © 2017 Elsevier Ltd. All rights reserved.

5 CFR 890.1047 - Special rules for institutional providers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... institutional providers. (a) Covered individual admitted before debarment or suspension. If a covered person is admitted as an inpatient before the effective date of an institutional provider's debarment or suspension... SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Administrative Sanctions Imposed...

77 FR 28786 - Disaster Assistance; Crisis Counseling Regular Program; Amendment to Regulation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... individuals can call the National Suicide Prevention Lifeline at 1-800-273-TALK or via the Web at http://www.suicidepreventionlifeline.org . Callers are routed to a suicide prevention call center near them based on the area code from...

34 CFR 105.10 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall provide an opportunity to interested persons, including individuals with handicaps or...

34 CFR 105.10 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall provide an opportunity to interested persons, including individuals with handicaps or...

34 CFR 105.10 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall provide an opportunity to interested persons, including individuals with handicaps or...

34 CFR 105.10 - Self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall provide an opportunity to interested persons, including individuals with handicaps or...

Developing and Implementing a New Prison-Based Buprenorphine Treatment Program

ERIC Educational Resources Information Center

Kinlock, Timothy W.; Gordon, Michael S.; Schwartz, Robert P.; Fitzgerald, Terrence T.

2010-01-01

Research suggests that buprenorphine treatment may be a promising intervention for incarcerated individuals with heroin addiction histories. However, its implementation varies from corrections-based methadone because of unique challenges regarding dosing, administration, and regulation. Describing the first randomized clinical trial of…

48 CFR 9903.201-7 - Cognizant Federal agency responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... responsibilities. 9903.201-7 Section 9903.201-7 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS... COST ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.201-7 Cognizant Federal... actions will provide greater assurances that individual contractors follow their cost accounting practices...

Rainwater harvesting state regulations and technical resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loper, Susan A.

Pacific Northwest National Laboratory (PNNL) conducted in-depth research of state-level rainwater harvesting regulations for the Federal Energy Management Program (FEMP) to help federal agencies strategically identify locations conducive to rainwater harvesting projects. Currently, rainwater harvesting is not regulated by the federal government but rather it is up to individual states to regulate the collection and use of rainwater. There is no centralized information on state-level regulations on rainwater harvesting maintained by a federal agency or outside organization. To fill this information gap, PNNL performed detailed internet searches for each state, which included state agencies, universities, Cooperative Extension Offices, city governments,more » and related organizations. The state-by-state information on rainwater harvesting regulations was compiled and assembled into an interactive map that is color coded by state regulations. The map provides a visual representation of the general types of rainwater harvesting policies across the country as well as general information on the state programs if applicable. The map allows the user to quickly discern where rainwater harvesting is supported and regulated by the state. This map will be available on the FEMP website by September 2015.« less

The replication domain model: regulating replicon firing in the context of large-scale chromosome architecture.

PubMed

Pope, Benjamin D; Gilbert, David M

2013-11-29

The "Replicon Theory" of Jacob, Brenner, and Cuzin has reliably served as the paradigm for regulating the sites where individual replicons initiate replication. Concurrent with the replicon model was Taylor's demonstration that plant and animal chromosomes replicate segmentally in a defined temporal sequence, via cytologically defined units too large to be accounted for by a single replicon. Instead, there seemed to be a program to choreograph when chromosome units replicate during S phase, executed by initiation at clusters of individual replicons within each segment. Here, we summarize recent molecular evidence for the existence of such units, now known as "replication domains", and discuss how the organization of large chromosomes into structural units has added additional layers of regulation to the original replicon model. Copyright © 2012 Elsevier Ltd. All rights reserved.

45 CFR 233.80 - Disability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Disability. 233.80 Section 233.80 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR... in light of his impairment; an individual's disability would usually be tested in relation to ability...

5 CFR 890.304 - Termination of enrollment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Enrollment § 890.304 Termination of... individual contract for health benefits. (e) Temporary continuation of coverage. Employees and family members... entitling him or her to benefits under part 353 of this chapter, or similar authority, for the purpose of...

5 CFR 890.304 - Termination of enrollment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Enrollment § 890.304 Termination of... individual contract for health benefits. (e) Temporary continuation of coverage. Employees and family members... entitling him or her to benefits under part 353 of this chapter, or similar authority, for the purpose of...

45 CFR 1176.1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.1 General. (a) Purpose. Many individuals in... National Endowment for the Humanities will operate a part-time career employment program, consistent with...

34 CFR 105.40 - Communications.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... afford an individual with handicaps an equal opportunity to participate in, and enjoy the benefits of, a...

34 CFR 105.40 - Communications.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... afford an individual with handicaps an equal opportunity to participate in, and enjoy the benefits of, a...

5 CFR 870.908 - Annuitants and compensationers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Assignments of Life Insurance § 870.908 Annuitants and compensationers. (a) If an employee assigns Basic insurance and later becomes...) At the time he/she retires or becomes eligible as a compensationer, the insured individual may elect...

5 CFR 870.908 - Annuitants and compensationers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Assignments of Life Insurance § 870.908 Annuitants and compensationers. (a) If an employee assigns Basic insurance and later becomes...) At the time he/she retires or becomes eligible as a compensationer, the insured individual may elect...

76 FR 718 - General Administrative Regulations; Good-Performance Refunds

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-06

... demonstrate good farming practices, providing, in effect, a premium discount to individual producers... Refund program will specifically encourage sound management practices as well as encouraging insured... regardless of the size of their farming operation. The amount of work required of the insurance companies...

ENVIRONMENTAL TECHNOLOGY REPORT - LEAD DUST WIPE MEASUREMENT TECHNOLOGY MONITORING TECHNOLOGIES INTERNATIONAL, PDV 5000 TRACE ELEMENT ANALYZER

EPA Science Inventory

ETV works in partnership with recognized standards and testing organizations and stakeholder groups consisting of regulators, buyers, and vendor organizations, with the full participation of individual technology developers. The program evaluates the performance of innovative

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - LEAD IN DUST WIPE MEASUREMENT TECHNOLOGY, PALINTEST, SCANNING ANALYZER , SA-5000 SYSTEM

EPA Science Inventory

ETV works in partnership with recognized standards and testing organizations and stakeholder groups consisting of regulators, buyers, and vendor organizations, with the full participation of individual technology developers. The program evaluates the performance of innovative

34 CFR 1100.12 - What applications are not evaluated for funding?

Code of Federal Regulations, 2012 CFR

2012-07-01

....12 Section 1100.12 Education Regulations Relating to Education NATIONAL INSTITUTE FOR LITERACY NATIONAL INSTITUTE FOR LITERACY: LITERACY LEADER FELLOWSHIP PROGRAM How Does an Individual Apply for a... of the procedural rules that govern the submission of applications for Literacy Leader Fellowship...

34 CFR 1100.12 - What applications are not evaluated for funding?

Code of Federal Regulations, 2014 CFR

2014-07-01

....12 Section 1100.12 Education Regulations Relating to Education NATIONAL INSTITUTE FOR LITERACY NATIONAL INSTITUTE FOR LITERACY: LITERACY LEADER FELLOWSHIP PROGRAM How Does an Individual Apply for a... of the procedural rules that govern the submission of applications for Literacy Leader Fellowship...

34 CFR 1100.12 - What applications are not evaluated for funding?

Code of Federal Regulations, 2013 CFR

2013-07-01

....12 Section 1100.12 Education Regulations Relating to Education NATIONAL INSTITUTE FOR LITERACY NATIONAL INSTITUTE FOR LITERACY: LITERACY LEADER FELLOWSHIP PROGRAM How Does an Individual Apply for a... of the procedural rules that govern the submission of applications for Literacy Leader Fellowship...

The stability of individual patterns of autonomic responses to motion sickness stimulation

NASA Technical Reports Server (NTRS)

Cowings, Patricia S.; Toscano, William B.; Naifeh, Karen H.

1990-01-01

As part of a program to develop a treatment for motion sickness based on self-regulation of autonomic nervous system (ANS) activity, this study examined the stability of an individual's pattern of ANS responses to motion sickness stimulation on repeated occasions. Motion sickness symptoms were induced in 58 people during two rotating chair test. Physiological responses measured were heart rate, finger pulse volume, respiration rate, and skin conductance. Using standard scores, stability of responses of specific magnitudes across both tests is as examined. Correlational analyses, analysis of variance, and a components of variance analysis all revealed marked, but quite stable, individual differences in ANS responses to both mild and severe motion sickness. These findings confirm the prior observation that people are sufficiently unique in their ANS responses to motion sickness provocation to make it nesessary to individually tailor self-regulation training. Further, these data support the contention that individual ANS patterns are sufficiently consistent from test to test so as to serve as an objective indicator of individual motion sickness malaise levels.

5 CFR 890.1013 - Deciding whether to propose a permissive debarment.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Administrative Sanctions Imposed Against Health Care Providers Permissive Debarments § 890.1013 Deciding whether to propose a... pose a risk to the health and safety of FEHBP-covered individuals or to the integrity of FEHBP...

7 CFR 273.5 - Students.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Students. 273.5 Section 273.5 Agriculture Regulations... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS § 273.5 Students. (a... the individual is enrolled in a regular curriculum at a college or university that offers degree...

10 CFR 602.6 - Eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Eligibility. 602.6 Section 602.6 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.6 Eligibility. Any individual or entity other than a Federal agency is eligible for a grant...

10 CFR 602.6 - Eligibility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Eligibility. 602.6 Section 602.6 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.6 Eligibility. Any individual or entity other than a Federal agency is eligible for a grant...

10 CFR 602.6 - Eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Eligibility. 602.6 Section 602.6 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.6 Eligibility. Any individual or entity other than a Federal agency is eligible for a grant...

34 CFR 105.20 - General prohibitions against discrimination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... individual with handicaps in the enjoyment of any right, privilege, advantage, or opportunity enjoyed by... Section 105.20 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES...

34 CFR 105.20 - General prohibitions against discrimination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... individual with handicaps in the enjoyment of any right, privilege, advantage, or opportunity enjoyed by... Section 105.20 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES...

34 CFR 105.20 - General prohibitions against discrimination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... individual with handicaps in the enjoyment of any right, privilege, advantage, or opportunity enjoyed by... Section 105.20 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES...

34 CFR 105.20 - General prohibitions against discrimination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... individual with handicaps in the enjoyment of any right, privilege, advantage, or opportunity enjoyed by... Section 105.20 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES...

34 CFR 105.20 - General prohibitions against discrimination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... individual with handicaps in the enjoyment of any right, privilege, advantage, or opportunity enjoyed by... Section 105.20 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES...

10 CFR 602.6 - Eligibility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Eligibility. 602.6 Section 602.6 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.6 Eligibility. Any individual or entity other than a Federal agency is eligible for a grant...

10 CFR 602.6 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Eligibility. 602.6 Section 602.6 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.6 Eligibility. Any individual or entity other than a Federal agency is eligible for a grant...

29 CFR 100.540 - Employment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Employment. 100.540 Section 100.540 Labor Regulations... § 100.540 Employment. No qualified individual with handicaps shall, on the basis of handicap, be subject to discrimination in employment under any program or activity conducted by the agency. The...

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - LEAD IN DUST WIPE MEASUREMENT TECHNOLOGY, KEYMASTER TECHNOLOGIES, X-RAY FLUORESCENCE INSTRUMENT PB-TEST

EPA Science Inventory

ETV works in partnership with recognized standards and testing organizations and stakeholder groups consisting of regulators, buyers, and vendor organizations, with the full participation of individual technology developers. The program evaluates the performance of innovative

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - LEAD IN DUST WIPE MEASUREMENT TECHNOLOGY, NITON CORPORATION, X-RAY FLURESCENCE SPECTRUM ANALYZER, XL-700

EPA Science Inventory

ETV works in partnership with recognized standards and testing organizations and stakeholder groups consisting of regulators, buyers, and vendor organizations, with the full participation of individual technology developers. The program evaluates the performance of innovative

48 CFR 324.102 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 324.102 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SOCIOECONOMIC PROGRAMS... HHS policy to protect the privacy of individuals to the maximum possible extent, while permitting the... Act (5 U.S.C. 552). The Privacy Act of 1974 and the HHS implementation under 45 CFR Part 5b apply...

48 CFR 324.102 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 324.102 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SOCIOECONOMIC PROGRAMS... HHS policy to protect the privacy of individuals to the maximum possible extent, while permitting the... Act (5 U.S.C. 552). The Privacy Act of 1974 and the HHS implementation under 45 CFR Part 5b apply...

7 CFR 272.6 - Nondiscrimination compliance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... beliefs. Discrimination in any aspect of program administration is prohibited by these regulations, the Food Stamp Act, the Age Discrimination Act of 1975 (Pub. L. 94-135), the Rehabilitation Act of 1973... file a complaint. Individuals who believe that they have been subject to discrimination as specified in...

7 CFR 272.6 - Nondiscrimination compliance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... beliefs. Discrimination in any aspect of program administration is prohibited by these regulations, the Food Stamp Act, the Age Discrimination Act of 1975 (Pub. L. 94-135), the Rehabilitation Act of 1973... file a complaint. Individuals who believe that they have been subject to discrimination as specified in...

7 CFR 272.6 - Nondiscrimination compliance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... beliefs. Discrimination in any aspect of program administration is prohibited by these regulations, the Food Stamp Act, the Age Discrimination Act of 1975 (Pub. L. 94-135), the Rehabilitation Act of 1973... file a complaint. Individuals who believe that they have been subject to discrimination as specified in...

FMCSA safety program effectiveness measurement : compliance review effectiveness model results for carriers with compliance reviews in FY 2008

DOT National Transportation Integrated Search

2012-09-30

In FY 2008, Federal and State enforcement personnel conducted 14,906 compliance reviews (CRs) on individual motor carriers. It is intended that through education, heightened safety regulation awareness, and the enforcement effects of the CR, carriers...

Sponsorship of physical activity programs by the sweetened beverages industry: public health or public relations?

PubMed

Gómez, Luis; Jacoby, Enrique; Ibarra, Lorena; Lucumí, Diego; Hernandez, Alexandra; Parra, Diana; Florindo, Alex; Hallal, Pedro

2011-04-01

The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the sugar-sweetened beverage industry practices intense lobbying at high government levels in several countries across the region. This strategy is accompanied by corporate social responsibility programs that fund initiatives promoting physical activity. These efforts, although appearing altruistic, are intended to improve the industry's public image and increase political influence in order to block regulations counter to their interests. If this industry wants to contribute to human well being, as it has publicly stated, it should avoid blocking legislative actions intended to regulate the marketing, advertising and sale of their products.

Parent and Child Perceptions of a Self-Regulated, Home-Based Exercise Program for Children with Cystic Fibrosis

PubMed Central

Happ, Mary Beth; Hoffman, Leslie A.; Higgins, Linda W.; DiVirgilio, Dana; Orenstein, David M.

2014-01-01

Background Despite recognized benefits, many children with cystic fibrosis (CF) do not consistently participate in physical activities. There is little empirical literature regarding the feelings and attitudes of children with CF toward exercise programs, parental roles in exercise, or factors influencing exercise experiences during research participation. Objectives To describe the exercise experiences of children with CF and their parents during participation in a six-month program of self-regulated, home-based exercise. Methods This qualitative descriptive study nested within a randomized controlled trial of a self-regulated, home-based exercise program used serial semi-structured interviews conducted individually at two and six months with 11 purposively selected children with CF and their parent(s). Results Six boys and five girls, ages 10–16, and parents (nine mothers, four fathers) participated in a total of 44 interviews. Five major thematic categories describing child and parent perceptions and experience of the bicycle exercise program were identified in the transcripts: (a) motivators; (b) barriers; (c) effort/work; (d) exercise routine; (e) sustaining exercise. Research participation, parent-family participation, health benefits, and the child’s personality traits were primary motivators. Competing activities, priorities and responsibilities were the major barriers to implementing the exercise program as prescribed. Motivation waned and the novelty wore off for several (approximately half) parent-child dyads, who planned to decrease or stop the exercise program after the study ended. Discussion We identified motivators and barriers to a self-regulated, home-based exercise program for children with CF that can be addressed in planning future exercise interventions to maximize the health benefits for children with CF and the feasibility and acceptability to the children and their families. PMID:23995464

Parent and child perceptions of a self-regulated, home-based exercise program for children with cystic fibrosis.

PubMed

Happ, Mary Beth; Hoffman, Leslie A; Higgins, Linda W; Divirgilio, Dana; DiVirgilio, Dana; Orenstein, David M

2013-01-01

Despite recognized benefits, many children with cystic fibrosis (CF) do not consistently participate in physical activities. There is little empirical literature regarding the feelings and attitudes of children with CF toward exercise programs, parental roles in exercise, or factors influencing exercise experiences during research participation. The aim of this study is to describe the exercise experiences of children with CF and their parents during participation in a 6-month program of self-regulated, home-based exercise. This qualitative descriptive study was nested within a randomized controlled trial of a self-regulated, home-based exercise program and used serial semistructured interviews conducted individually at 2 and 6 months with 11 purposively selected children with CF and their parent(s). Six boys and five girls, ages 10-16 years, and parents(nine mothers, four fathers) participated in a total of 44 interviews. Five major thematic categories describing child and parent perceptions and experience of the bicycle exercise program were identified in the transcripts: (a) motivators, (b) barriers, (c) effort/work, (d) exercise routine, and (e) sustaining exercise. Research participation, parent-family participation, health benefits, and the child's personality traits were the primary motivators. Competing activities, priorities, and responsibilities were the major barriers in implementing the exercise program as prescribed. Motivation waned, and the novelty wore off for several (approximately half) parent-child dyads, who planned to decrease or stop the exercise program after the study ended. We identified motivators and barriers to a self-regulated, home-based exercise program for children with CF that can be addressed in planning future exercise interventions to maximize the health benefits for children with CF and the feasibility and acceptability to the children and their families.

5 CFR 890.807 - When do enrollments terminate, cancel or suspend?

Code of Federal Regulations, 2014 CFR

2014-01-01

... SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Benefits for Former Spouses... on whose service the health benefits are based. (2) OPM may authorize a longer time frame for the... individual contract for health benefits. (4) A former spouse who cancels his or her enrollment for any reason...

5 CFR 890.807 - When do enrollments terminate, cancel or suspend?

Code of Federal Regulations, 2011 CFR

2011-01-01

... SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Benefits for Former Spouses... on whose service the health benefits are based. (2) OPM may authorize a longer time frame for the... individual contract for health benefits. (4) A former spouse who cancels his or her enrollment for any reason...

5 CFR 890.807 - When do enrollments terminate, cancel or suspend?

Code of Federal Regulations, 2013 CFR

2013-01-01

... SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Benefits for Former Spouses... on whose service the health benefits are based. (2) OPM may authorize a longer time frame for the... individual contract for health benefits. (4) A former spouse who cancels his or her enrollment for any reason...

34 CFR 350.55 - What are the additional considerations for selecting Field-Initiated Project applications for...

Code of Federal Regulations, 2010 CFR

2010-07-01

... knowledge to improve the lives of individuals with disabilities. (2) The proposed project complements... Field-Initiated Project applications for funding? 350.55 Section 350.55 Education Regulations of the..., DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM How Does the...

77 FR 25378 - Regulations Pertaining to the Disclosure of Return Information To Carry Out Eligibility...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... Health Insurance Affordability Programs AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice... marketplaces for individuals and small employers to directly compare available private health insurance options...-based Exchange. In general, a QHP is a health plan offered by a health insurance issuer that meets...

7 CFR 273.5 - Students.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false Students. 273.5 Section 273.5 Agriculture Regulations... § 273.5 Students. (a) Applicability. An individual who is enrolled at least half-time in an institution... college or university that offers degree programs regardless of whether a high school diploma is required...

7 CFR 273.5 - Students.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Students. 273.5 Section 273.5 Agriculture Regulations... § 273.5 Students. (a) Applicability. An individual who is enrolled at least half-time in an institution... college or university that offers degree programs regardless of whether a high school diploma is required...

7 CFR 273.5 - Students.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 4 2014-01-01 2014-01-01 false Students. 273.5 Section 273.5 Agriculture Regulations... § 273.5 Students. (a) Applicability. An individual who is enrolled at least half-time in an institution... college or university that offers degree programs regardless of whether a high school diploma is required...

FMCSA safety program effectiveness measurement : compliance review effectiveness model results for carriers with compliance reviews in fiscal year 2009.

DOT National Transportation Integrated Search

2014-04-01

In FY 2009, Federal and State enforcement personnel conducted more than 15,000 compliance reviews (CRs) on individual motor carriers. It is intended that through education, heightened safety regulation awareness, and the enforcement effects of the CR...

40 CFR 141.571 - What records does subpart T require my system to keep?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer Than 10,000 People Reporting and Recordkeeping Requirements § 141.571 What....560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling...

FMCSA safety program effectiveness measurement : compliance review effectiveness model results for carriers with compliance reviews in FY 2007

DOT National Transportation Integrated Search

2012-09-30

In FY 2007, Federal and State enforcement personnel conducted more than 15,000 CRs on individual motor carriers. It is intended that through education, heightened safety regulation awareness, and the enforcement effects of the CR, carriers will impro...

IEP's: A Gateway for Legal Entanglement.

ERIC Educational Resources Information Center

Connors, Eugene T.; Vacca, Richard S.

The section of the Education for All Handicapped Children Act (P.L. 94-142) detailing "appropriate education" as a function of an Individualized Education Program (IEP) regulates a variety of educational considerations. Arguing that the IEP is in fact "the hub of the special education wheel," the authors of this document begin…

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - LEAD IN DUST WIPE MEASUREMENT TECHNOLOGY, NITON CORPORATION, X-RAY FLUORESCENCE SPECTRUM ANALYSER, XL-300 SERIES

EPA Science Inventory

ETV works in partnership with recognized standards and testing organizations and stakeholder groups consisting of regulators, buyers, and vendor organizations, with the full participation of individual technology developers. The program evaluates the performance of innovative

NPDES (National Pollution Discharge & Elimination System) Minor Dischargers

EPA Pesticide Factsheets

As authorized by the Clean Water Act, the National Pollutant Discharge Elimination System (NPDES) permit program controls water pollution by regulating point sources that discharge pollutants into waters of the United States. The NPDES permit program regulates direct discharges from municipal and industrial wastewater treatment facilities that discharge directly into surface waters. The NPDES permit program is part of the Permit Compliance System (PCS) which issues, records, tracks, and regulates point source discharge facilities. Individual homes that are connected to a municipal system, use a septic system, or do not have a surface discharge do not need an NPDES permit. Facilities in PCS are identified as either major or minor. Within the major/minor classification, facilities are grouped into municipals or non-municipals. In many cases, non-municipals are industrial facilities. This data layer contains Minor dischargers. Major municipal dischargers include all facilities with design flows of greater than one million gallons per day; minor dischargers are less that one million gallons per day. Essentially, a minor discharger does not meet the discharge criteria for a major. Since its introduction in 1972, the NPDES permit program is responsible for significant improvements to our Nation's water quality.

State policies and the financing of acquired immunodeficiency syndrome care

PubMed Central

Pascal, Anthony; Cvitanic, Marilyn; Bennett, Charles; Gorman, Michael; Serrato, Carl A.

1989-01-01

State policies, with respect to the operation of Medicaid programs and the regulation of private health insurance, affect who gets what care, how much is spent, and who ultimately pays. A RAND Corporation study was used to assess States and the District of Columbia in terms of the effects of their Medicaid and health insurance regulations on people with acquired immunodeficiency syndrome and other human immunodeficiency virus-related illnesses. State characteristics are used to explain the individual State policy rankings. PMID:10313357

Integrating co-morbid depression and chronic physical disease management: identifying and resolving failures in self-regulation.

PubMed

Detweiler-Bedell, Jerusha B; Friedman, Michael A; Leventhal, Howard; Miller, Ivan W; Leventhal, Elaine A

2008-12-01

Research suggests that treatments for depression among individuals with chronic physical disease do not improve disease outcomes significantly, and chronic disease management programs do not necessarily improve mood. For individuals experiencing co-morbid depression and chronic physical disease, demands on the self-regulation system are compounded, leading to a rapid depletion of self-regulatory resources. Because disease and depression management are not integrated, patients lack the understanding needed to prioritize self-regulatory goals in a way that makes disease and depression management synergistic. A framework in which the management of co-morbidity is considered alongside the management of either condition alone offers benefits to researchers and practitioners and may help improve clinical outcomes.

Social Regulation of Human Gene Expression: Mechanisms and Implications for Public Health

PubMed Central

2013-01-01

Recent analyses have discovered broad alterations in the expression of human genes across different social environments. The emerging field of social genomics has begun to identify the types of genes sensitive to social regulation, the biological signaling pathways mediating these effects, and the genetic polymorphisms that modify their individual impact. The human genome appears to have evolved specific “social programs” to adapt molecular physiology to the changing patterns of threat and opportunity ancestrally associated with changing social conditions. In the context of the immune system, this programming now fosters many of the diseases that dominate public health. The embedding of individual genomes within a broader metagenomic network provides a framework for integrating molecular, physiologic, and social perspectives on human health. PMID:23927506

Integrating Co-Morbid Depression and Chronic Physical Disease Management: Identifying and Resolving Failures in Self-Regulation

PubMed Central

Detweiler-Bedell, Jerusha B.; Friedman, Michael A.; Leventhal, Howard; Miller, Ivan W.; Leventhal, Elaine A.

2008-01-01

Research suggests that treatments for depression among individuals with chronic physical disease do not improve disease outcomes significantly, and chronic disease management programs do not necessarily improve mood. For individuals experiencing co-morbid depression and chronic physical disease, demands on the self-regulation system are compounded, leading to a rapid depletion of self-regulatory resources. Because disease and depression management are not integrated, patients lack the understanding needed to prioritize self-regulatory goals in a way that makes disease and depression management synergistic. A framework in which the management of co-morbidity is considered alongside the management of either condition alone offers benefits to researchers and practitioners and may help improve clinical outcomes. PMID:18848740

49 CFR 385.313 - Who will conduct the safety audit?

Code of Federal Regulations, 2010 CFR

2010-10-01

... FITNESS PROCEDURES New Entrant Safety Assurance Program § 385.313 Who will conduct the safety audit? An individual certified under the FMCSA regulations to perform safety audits will conduct the safety audit. ... 49 Transportation 5 2010-10-01 2010-10-01 false Who will conduct the safety audit? 385.313 Section...

77 FR 70619 - Incentives for Nondiscriminatory Wellness Programs in Group Health Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

...-2713T, 29 CFR 2590.715-2713, and 45 CFR 147.130 require non-grandfathered group health plans and health insurance issuers offering non-grandfathered group or individual health insurance coverage to provide... paragraph (f) of the 2006 regulations and would apply to both grandfathered and non- grandfathered group...

77 FR 41343 - Approval and Promulgation of Implementation Plans; North Dakota: Prevention of Significant...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the Air Program, Environmental Protection... possible, you contact the individual listed in the FOR FURTHER INFORMATION CONTACT section to view the hard...

From Standards to Compliance, to Good Services, to Quality Lives: Is This How It Works?

ERIC Educational Resources Information Center

Shea, John R.

1992-01-01

Licensing and certification regulations for Intermediate Care Facilities for the Mentally Retarded (ICF/MR) can adversely affect individuals, distort the allocation of scarce resources, and encourage community residences to become small institutions. A case study of one home in northern California illustrates poor program evaluation and the need…

45 CFR 2551.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2012 CFR

2012-10-01

... National Service Criminal History Check? 2551.29 Section 2551.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

45 CFR 2551.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2011 CFR

2011-10-01

... National Service Criminal History Check? 2551.29 Section 2551.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

45 CFR 2552.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2012 CFR

2012-10-01

... National Service Criminal History Check? 2552.29 Section 2552.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

45 CFR 2552.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2011 CFR

2011-10-01

... National Service Criminal History Check? 2552.29 Section 2552.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

45 CFR 2552.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2010 CFR

2010-10-01

... National Service Criminal History Check? 2552.29 Section 2552.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

45 CFR 2551.29 - What procedures must I follow in conducting a National Service Criminal History Check?

Code of Federal Regulations, 2010 CFR

2010-10-01

... National Service Criminal History Check? 2551.29 Section 2551.29 Public Welfare Regulations Relating to... Service Criminal History Check? You are responsible for ensuring that the following procedures are... program is contingent upon the organization's review of the individual's criminal history, if any; (d...

34 CFR 300.321 - IEP Team.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 2 2013-07-01 2013-07-01 false IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

34 CFR 300.321 - IEP Team.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

34 CFR 300.321 - IEP Team.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

34 CFR 300.321 - IEP Team.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

34 CFR 300.321 - IEP Team.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

76 FR 56712 - CLIA Program and HIPAA Privacy Rule; Patients' Access to Test Reports

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

...; Patients' Access to Test Reports AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS; Centers for...) regulations to specify that, upon a patient's request, the laboratory may provide access to completed test... provide for release of test reports to authorized persons and, if applicable, the individuals (or their...

78 FR 27115 - Draft Guidance for Industry on Expanded Access to Investigational Drugs for Treatment Use...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... a more transparent process by increasing awareness and knowledge of expanded access programs and the... regulations. Consistent with the goal of making expanded access processes more transparent, FDA is providing... (IRB) review and approval required for individual patient expanded access?'' In the draft guidance, FDA...

Burnout syndrome and wellbeing in anesthesiologists: the importance of emotion regulation strategies.

PubMed

Lapa, Teresa A; Madeira, Filipa M; Viana, Joaquim S; Pinto-Gouveia, José

2017-02-01

Anesthesiologists face stressful working conditions that can culminate in burnout syndrome. Despite various studies and protective measures which have attempted to prevent this situation, burnout continues to be a problem within the profession, impacting negatively on physicians' lives and their performance. In this review article mechanisms and consequences of burnout are described in addition to individual strategies for stress management and burnout reduction with potential impact on health care quality and wellbeing in anesthesiologists. Organizational strategies appear to have an important role in burnout reduction but need to be used in conjunction with individual programs. The latter are essential to both reducing stress and burnout in anesthesiologists and improving happiness and wellbeing. New measures of emotion regulation strategies such as mindfulness, self-compassion, resilience and empathy promotion have been shown to be approaches with substantial supporting evidence for reducing burnout and improving stress management. The evaluation and implementation of these self-regulatory competencies is a challenge. Further research is necessary to identify which programs will best suit the needs of anesthesiologists and to measure their effects on patient care and health care system quality.

Multilevel regulation of gene expression by microRNAs.

PubMed

Makeyev, Eugene V; Maniatis, Tom

2008-03-28

MicroRNAs (miRNAs) are approximately 22-nucleotide-long noncoding RNAs that normally function by suppressing translation and destabilizing messenger RNAs bearing complementary target sequences. Some miRNAs are expressed in a cell- or tissue-specific manner and may contribute to the establishment and/or maintenance of cellular identity. Recent studies indicate that tissue-specific miRNAs may function at multiple hierarchical levels of gene regulatory networks, from targeting hundreds of effector genes incompatible with the differentiated state to controlling the levels of global regulators of transcription and alternative pre-mRNA splicing. This multilevel regulation may allow individual miRNAs to profoundly affect the gene expression program of differentiated cells.

Inferring rules of lineage commitment in haematopoiesis.

PubMed

Pina, Cristina; Fugazza, Cristina; Tipping, Alex J; Brown, John; Soneji, Shamit; Teles, Jose; Peterson, Carsten; Enver, Tariq

2012-02-19

How the molecular programs of differentiated cells develop as cells transit from multipotency through lineage commitment remains unexplored. This reflects the inability to access cells undergoing commitment or located in the immediate vicinity of commitment boundaries. It remains unclear whether commitment constitutes a gradual process, or else represents a discrete transition. Analyses of in vitro self-renewing multipotent systems have revealed cellular heterogeneity with individual cells transiently exhibiting distinct biases for lineage commitment. Such systems can be used to molecularly interrogate early stages of lineage affiliation and infer rules of lineage commitment. In haematopoiesis, population-based studies have indicated that lineage choice is governed by global transcriptional noise, with self-renewing multipotent cells reversibly activating transcriptome-wide lineage-affiliated programs. We examine this hypothesis through functional and molecular analysis of individual blood cells captured from self-renewal cultures, during cytokine-driven differentiation and from primary stem and progenitor bone marrow compartments. We show dissociation between self-renewal potential and transcriptome-wide activation of lineage programs, and instead suggest that multipotent cells experience independent activation of individual regulators resulting in a low probability of transition to the committed state.

De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia.

PubMed

Sawtell, Nancy M; Thompson, Richard L

2016-09-01

The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represents a pivot point where largely unknown mechanisms lead to a latent or a lytic infection in the neuron. Regulation at this pivot point is critical for balancing two objectives, efficient widespread seeding of the nervous system and host survival. By combining genetic and in vivo in approaches, our studies reveal that the balance between latent and lytic programs is a process occurring early in the trigeminal ganglion. Unexpectedly, activation of the latent program precedes entry into the lytic program by 12 -14hrs. Importantly, at the individual neuronal level, the lytic program begins as a transition out of this acute stage latent program and this escape from the default latent program is regulated by de novo VP16 expression. Our findings support a model in which regulated de novo VP16 expression in the neuron mediates entry into the lytic cycle during the earliest stages of virus infection in vivo. These findings support the hypothesis that the loose association of VP16 with the viral tegument combined with sensory axon length and transport mechanisms serve to limit arrival of virion associated VP16 into neuronal nuclei favoring latency. Further, our findings point to specialized features of the VP16 promoter that control the de novo expression of VP16 in neurons and this regulation is a key component in setting the balance between lytic and latent infections in the nervous system.

De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia

PubMed Central

Sawtell, Nancy M.; Thompson, Richard L.

2016-01-01

The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represents a pivot point where largely unknown mechanisms lead to a latent or a lytic infection in the neuron. Regulation at this pivot point is critical for balancing two objectives, efficient widespread seeding of the nervous system and host survival. By combining genetic and in vivo in approaches, our studies reveal that the balance between latent and lytic programs is a process occurring early in the trigeminal ganglion. Unexpectedly, activation of the latent program precedes entry into the lytic program by 12 -14hrs. Importantly, at the individual neuronal level, the lytic program begins as a transition out of this acute stage latent program and this escape from the default latent program is regulated by de novo VP16 expression. Our findings support a model in which regulated de novo VP16 expression in the neuron mediates entry into the lytic cycle during the earliest stages of virus infection in vivo. These findings support the hypothesis that the loose association of VP16 with the viral tegument combined with sensory axon length and transport mechanisms serve to limit arrival of virion associated VP16 into neuronal nuclei favoring latency. Further, our findings point to specialized features of the VP16 promoter that control the de novo expression of VP16 in neurons and this regulation is a key component in setting the balance between lytic and latent infections in the nervous system. PMID:27607440

78 FR 58202 - Federal Tort Claims Act (FTCA) Medical Malpractice Program Regulations: Clarification of FTCA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

... added examples of services covered under the FTCA involving individual emergency care provided to a non-health center patient and updated the September 1995 Notice immunization example to include events to...) on May 8, 1995, and added a new part 6 to 42 CFR Chapter I, Subchapter A. This rule describes the...

New York State Plan for Education of Students with Disabilities, 1993-1995.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Office for Special Education Services.

This state plan describes how the state of New York intends to comply with legislative mandates concerning education of children with disabilities, specifically the Individuals with Disabilities Education Act (IDEA) and Part 300 of the Code of Federal Regulations. It also describes the planning and program initiatives that will be undertaken at…

45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

Code of Federal Regulations, 2014 CFR

2014-10-01

... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

Code of Federal Regulations, 2013 CFR

2013-10-01

... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

45 CFR 261.32 - How many hours must work-eligible individuals participate for the family to count in the...

Code of Federal Regulations, 2012 CFR

2012-10-01

... participate for the family to count in the numerator of the two-parent rate? 261.32 Section 261.32 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK...

Personality, Resilience, Self-Regulation and Cognitive Ability Relevant to Teacher Selection

ERIC Educational Resources Information Center

Sautelle, Eleanor; Bowles, Terry; Hattie, John; Arifin, Daniel N.

2015-01-01

The current study uses social judgment theory to inform the design of processes to be used in selecting teachers for training programs. Developing a comprehensive selection process to identify individuals who are likely to succeed as teachers is a mechanism for improving teacher quality and raising the profile of the profession. The design of such…

34 CFR 361.32 - Use of profitmaking organizations for on-the-job training in connection with selected projects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... individuals with disabilities under the Projects With Industry program, 34 CFR part 379, if the designated... training in connection with selected projects. 361.32 Section 361.32 Education Regulations of the Offices... on-the-job training in connection with selected projects. The State plan must assure that the...

From Assessment to Annual Goal: Engaging a Decision-Making Process in Writing Measurable IEPs

ERIC Educational Resources Information Center

Capizzi, Andrea M.

2008-01-01

Despite federal regulations requiring measurable individualized education programs (IEPs), IEPs are often vague and unfocused, making them difficult to use in guiding instructional planning. Although a well-written IEP can be time consuming and labor intensive, a clearly written IEP, based on documented student needs, can and should be a guidepost…

44 CFR 206.119 - Financial assistance to address other needs.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) established under the National Flood Insurance Program (NFIP) regulations at 44 CFR 61.17. (1) The premium for... this portion of the Other Needs award and provide it to the NFIP on behalf of individuals and... established under section 408 of the Stafford Act. (2) FEMA or the State IHP staff shall provide the NFIP with...

44 CFR 206.119 - Financial assistance to address other needs.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) established under the National Flood Insurance Program (NFIP) regulations at 44 CFR 61.17. (1) The premium for... this portion of the Other Needs award and provide it to the NFIP on behalf of individuals and... established under section 408 of the Stafford Act. (2) FEMA or the State IHP staff shall provide the NFIP with...

44 CFR 206.119 - Financial assistance to address other needs.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) established under the National Flood Insurance Program (NFIP) regulations at 44 CFR 61.17. (1) The premium for... this portion of the Other Needs award and provide it to the NFIP on behalf of individuals and... established under section 408 of the Stafford Act. (2) FEMA or the State IHP staff shall provide the NFIP with...

7 CFR Appendix B to Part 3015 - OMB Circular A-128, “Audits of State and Local Governments”

Code of Federal Regulations, 2010 CFR

2010-01-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... regulations. a. Internal control review. In order to provide this assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and...

7 CFR Appendix B to Part 3015 - OMB Circular A-128, “Audits of State and Local Governments”

Code of Federal Regulations, 2011 CFR

2011-01-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... regulations. a. Internal control review. In order to provide this assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and...

7 CFR Appendix B to Part 3015 - OMB Circular A-128, “Audits of State and Local Governments”

Code of Federal Regulations, 2014 CFR

2014-01-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... regulations. a. Internal control review. In order to provide this assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and...

8 CFR 286.8 - Establishment of pilot programs for the charging of a land border fee for inspection services.

Code of Federal Regulations, 2010 CFR

2010-01-01

... DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.8 Establishment of pilot... charge fees for immigration inspection services to be collected by the Commissioner. Individual ports-of... inspection services and to recover the cost of: (a) Hiring additional immigration inspectors, including all...

Mining Properties in Oregon that were Involved in the DMA, DMEA, OME Mineral Exploration Programs, 1950-1974

USGS Publications Warehouse

Kiilsgaard, Thor H.

1998-01-01

Introduction This report and accompanying map (Plate 1) presents information on the Defense Minerals Administration (DMA), Defense Minerals Exploration Administration (DMEA), and Office of Minerals Exploration (OME) mineral exploration programs in Oregon. Under these programs, the federal government participated in the exploration costs for certain strategic and critical minerals. Federal funds for mineral exploration under the programs were available from 1950 to 1974, although limited funds for OME administrative work were continued until 1979. The report reviews the three programs, associated regulations, administrative procedures, and operational techniques. It also describes the various types of informative reports on individual mining properties generated by the programs, lists properties in Oregon that were involved in the different exploration programs, and advises on the location of compiled information that resulted from the work.

Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs

PubMed Central

Hu, Yuanxin; Matkovich, Scot J.; Hecker, Peter A.; Zhang, Yan; Edwards, John R.; Dorn, Gerald W.

2012-01-01

Cardiac stress responses are driven by an evolutionarily conserved gene expression program comprising dozens of microRNAs and hundreds of mRNAs. Functionalities of different individual microRNAs are being studied, but the overall purpose of interactions between stress-regulated microRNAs and mRNAs and potentially distinct roles for microRNA-mediated epigenetic and conventional transcriptional genetic reprogramming of the stressed heart are unknown. Here we used deep sequencing to interrogate microRNA and mRNA regulation in pressure-overloaded mouse hearts, and performed a genome-wide examination of microRNA–mRNA interactions during early cardiac hypertrophy. Based on abundance and regulatory patterns, cardiac microRNAs were categorized as constitutively expressed housekeeping, regulated homeostatic, or dynamic early stress-responsive microRNAs. Regulation of 62 stress-responsive cardiac microRNAs directly affected levels of only 66 mRNAs, but the global impact of microRNA-mediated epigenetic regulation was amplified by preferential targeting of mRNAs encoding transcription factors, kinases, and phosphatases exerting amplified secondary effects. Thus, an emergent cooperative property of stress-regulated microRNAs is orchestration of transcriptional and posttranslational events that help determine the stress-reactive cardiac phenotype. This global functionality explains how large end-organ effects can be induced through modest individual changes in target mRNA and protein content by microRNAs that sense and respond dynamically to a changing physiological milieu. PMID:23150554

The impact of experienced emotion on evaluative judgments: the effects of age and emotion regulation style.

PubMed

Hess, Thomas M; Beale, Karen S; Miles, Amanda

2010-11-01

Adults aged from 24 to 79 were exposed to four commercial advertisements within the context of television programs designed to induce either a positive or negative mood. Although age was associated with memory for the content of the commercials, it did not moderate the impact of mood on evaluations of the advertised products. Instead, participants who reported engaging in expressive suppression as a common emotion regulation strategy were more likely to make evaluations that were biased by moods than those individuals who reported low use of this strategy. The results suggest that the maintenance of emotion regulation ability in later adulthood may help people control certain affective influences on thought.

Dialectical Behavior Therapy Group Skills Training for Bipolar Disorder.

PubMed

Eisner, Lori; Eddie, David; Harley, Rebecca; Jacobo, Michelle; Nierenberg, Andrew A; Deckersbach, Thilo

2017-07-01

There is growing evidence that the capacity for emotion regulation is compromised in individuals with bipolar disorder. Dialectical behavior therapy (DBT), an empirically supported treatment that specifically targets emotion dysregulation, may be an effective adjunct treatment for improving emotion regulation and residual mood symptoms in patients with bipolar disorder. In this open, proof-of-concept pilot study, 37 participants engaged in a 12-week DBT group skills training program, learning mindfulness, emotion regulation, and distress tolerance skills. Repeated measures mixed models revealed skill acquisition in the areas of mindfulness, emotion regulation and distress tolerance, as well as improved psychological well-being and decreased emotion reactivity. The results of this study support a burgeoning literature that DBT is a feasible adjunct intervention for patients with bipolar disorder. Copyright © 2017. Published by Elsevier Ltd.

A Statewide Evaluation of the California Medical Supervision Program Using Cholinesterase Electronic Laboratory Reporting Data

PubMed Central

Laribi, Ouahiba; Malig, Brian; Sutherland-Ashley, Katherine; Broadwin, Rachel; Wieland, Walker; Salocks, Charles

2017-01-01

The California Medical Supervision program is designed to protect workers who regularly mix, load, or apply the highly toxic Category I and II organophosphates and carbamates from overexposure by monitoring cholinesterase (ChE) inhibition in plasma and red blood cells. Since January 2011, testing laboratories are required to report test results electronically to the California Department of Pesticide Regulation who shares it with the Office of Environmental Health Hazard Assessment for evaluation. The purpose of this study is to assess the utility of this reporting in evaluating the effectiveness of the Program for illness surveillance and prevention. From 2011 to 2013, we received more than 90 000 test results. Despite data gaps and data quality issues, we were able to perform spatial and temporal analyses and developed a screening tool to identify individuals potentially at risk of overexposure. The data analysis provided some evidence that the Program is effective in protecting agricultural workers handling the most toxic ChE-inhibiting pesticides even though it also identified some areas of potential concerns with individuals that appeared lacking corrective actions in the workplace in response to excessive ChE depressions and parts of the state with disproportionately at-risk individuals. However, changes to the electronic reporting are needed to more accurately identify tests related to the Program and therefore improve the utility of the data received. Moreover, data analysis also revealed that electronic reporting has its limitation in evaluating the Program.

Selfish cells in altruistic cell society - a theoretical oncology.

PubMed

Chigira, M

1993-09-01

In multicellular organisms, internal evolution of individual cells is strictly forbidden and 'evolutional' DNA replication should be performed only by the sexual reproduction system. Wholistic negative control system called 'homeostasis' serves all service to germ line cells. All somatic cells are altruistic to the germ line cells. However, in malignant tumors, it seems that individual cells replicate and behave 'selfishly' and evolve against the internal microenvironment. Tumor cells only express the occult selfishness which is programmed in normal cells a priori. This phenomenon is based on the failure of identical DNA replication, and results in 'autonomy' and 'anomie' of cellular society as shown in tumor cells. Genetic programs of normal cells connote this cellular autonomy and anomie introduced by the deletion of regulators on structure genes. It is rather paradoxical that the somatic cells get their freedom from wholistic negative regulation programmed internally. However, this is not a true paradox, since multicellular organisms have clearly been evolved from 'monads' in which cells proliferate without wholistic regulation. Somatic cells revolt against germ cell DNA, called 'selfish replicator' by Dawkins. It is an inevitable destiny that the 'selfishness' coded in genome should be revenged by itself. Selfish replicator in germ cell line should be revolted by its selfishness in the expansion of somatic cells, since they have an orthogenesis to get more selfishness in order to increase their genome. Tumor heterogeneity and progression can be fully explained by this self-contradictory process which produces heterogeneous gene copies different from the original clone in the tumor, although 'selfish' gene replication is the final target of being. Furthermore, we have to discard the concept of clonality of tumor cells since genetic instability is a fundamental feature of tumors. Finally, tumor cells and proto-oncogenes can be considered as the ultimate parasite to germ line cells.

Hanford Site Environmental Report 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

TM Poston; RW Hanf; RL Dirkes

This Hanford Site environmental report is prepared annually to summarize environmental data and information, to describe environmental management performance, to demonstrate the status of compliance with environmental regulations, and to highlight major environmental programs and efforts. The report is written to meet requirements and guidelines of the U.S. Department of Energy (DOE) and to meet the needs of the public. This summary has been written with a minimum of technical terminology. Individual sections of the report are designed to: (1) describe the Hanford Site and its mission; (2) summarize the status of compliance with environmental regulations; (3) describe the environmentalmore » programs at the Hanford Site; (4) discuss the estimated radionuclide exposure to the public from 1999 Hanford Site activities; (5) present the effluent monitoring, environmental surveillance, groundwater protection and monitoring information; and (6) discuss the activities to ensure quality.« less

Hanford Site 1998 Environmental Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

RL Dirkes; RW Hanf; TM Poston

This Hanford Site environmental report is prepared annually to summarize environmental data and information, to describe environmental management performance, to demonstrate the status of compliance with environmental regulations, and to highlight major environmental programs and efforts. The report is written to meet requirements and guidelines of the U.S. Department of Energy (DOE) and to meet the needs of the public. This summary has been written with a minimum of technical terminology. Individual sections of the report are designed to: describe the Hanford Site and its mission; summarize the status of compliance with environmental regulations; describe the environmental programs at themore » Hanford Site; discuss the estimated radionuclide exposure to the public from 1998 Hanford Site activities; present the effluent monitoring, environmental surveillance, and groundwater protection and monitoring information; and discuss the activities to ensure quality.« less

Feasibility of Using Video to Teach a Dialectical Behavior Therapy Skill to Clients with Borderline Personality Disorder

ERIC Educational Resources Information Center

Waltz, Jennifer; Dimeff, Linda A.; Koerner, Kelly; Linehan, Marsha M.; Taylor, Laura; Miller, Christopher

2009-01-01

This study tested the feasibility of using a psychoeducational video recording to teach a behavioral skill from the Dialectical Behavior Therapy (DBT; Linehan, 1993a, 1993b) skills training program to individuals meeting criteria for borderline personality disorder. A video presenting a DBT emotion-regulation skill was developed and the extent to…

7 CFR 1755.522 - RUS general specification for digital, stored program controlled central office equipment.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) shall be detected and the equivalent of a carrier group alarm shall be executed in 2.5 ±0.5 seconds.../federal_register/code_of_federal_regulations/ibr_locations.html. (b) Reliability. (1) Quality control and... designed such that the expected individual line downtime does not exceed 30 minutes per year. This is the...

45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

Code of Federal Regulations, 2013 CFR

2013-10-01

... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

Code of Federal Regulations, 2014 CFR

2014-10-01

... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

45 CFR 261.31 - How many hours must a work-eligible individual participate for the family to count in the...

Code of Federal Regulations, 2012 CFR

2012-10-01

... participate for the family to count in the numerator of the overall rate? 261.31 Section 261.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ENSURING THAT RECIPIENTS WORK What Are the...

78 FR 54875 - Privacy Act of 1974; Computer Matching Program Between the Department of Education (ED) and the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

....C. 1091(g) and (p). SSA will verify the issuance of an SSN to, and will confirm the citizenship... verifying the accuracy of each individual's SSN and claim to a citizenship status that permits that... the Code of Federal Regulations is available via the Federal Digital System at: www.gpo.gov/fsys . At...

Structural Relationships among Self-Regulated Learning, Learning Flow, Satisfaction, and Learning Persistence in Cyber Universities

ERIC Educational Resources Information Center

Joo, Young Ju; Joung, Sunyoung; Kim, Jiyeon

2014-01-01

Learning persistence in a cyber-learning environment is not only an index determining the success or failure of individual learners but also a source of important information to establish the management direction of educational programs in an organization. Accordingly, learners need to be motivated to continue to grow in order to ensure both…

School Accommodation and Modification Ideas for Students Who Receive Special Education Services. PACER Center ACTion Information Sheets: PHP-c49

ERIC Educational Resources Information Center

PACER Center, 2013

2013-01-01

Some students with disabilities who receive special education services need accommodations or modifications to their educational program in order to participate in the general curriculum and to be successful in school. While the Individuals with Disabilities Education Act (IDEA) and its regulations do not define accommodations or modifications,…

Free Appropriate Public Education for Students with Disabilities: Requirements under Section 504 of the "Rehabilitation Act of 1973." Revised

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

Section 504 of the "Rehabilitation Act of 1973" protects the rights of individuals with disabilities in programs and activities that receive federal funds. The Section 504 regulation requires a school district to provide a "free appropriate public education" (FAPE) to each qualified person with a disability who is in the school…

78 FR 68390 - Fisheries of the Exclusive Economic Zone Off Alaska; Bering Sea and Aleutian Islands Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-14

...NMFS proposes regulations to implement Amendment 102 to the Fishery Management Plan for Groundfish of the Bering Sea and Aleutian Islands Management Area (BSAI FMP), and amend the Individual Fishing Quota Program for the Fixed-Gear Commercial Fisheries for Pacific Halibut and Sablefish in Waters in and off Alaska (IFQ Program). Amendment 102 and its proposed implementing regulations would create a Community Quota Entity (CQE) Program in halibut IFQ regulatory area 4B (Area 4B) and the sablefish Aleutian Islands regulatory area that is similar to the existing CQE Program in the Gulf of Alaska (GOA). Amendment 102 would also allow an eligible community in Area 4B and in the Aleutian Islands to establish a non-profit organization as a CQE to purchase halibut catcher vessel quota share (QS) assigned to Area 4B and sablefish QS assigned to the Aleutian Islands. The CQE could assign the resulting annual halibut and sablefish IFQ to participants according to defined CQE Program elements. An additional proposed revision to the IFQ Program regulations would allow IFQ derived from D share halibut QS to be fished on Category C vessels in Area 4B. These actions are necessary to provide additional fishing opportunities for residents of fishery dependent communities and sustain participation in the halibut and sablefish IFQ fisheries. These actions are intended to promote the goals and objectives of the Magnuson-Stevens Fishery Conservation and Management Act, the Northern Pacific Halibut Act of 1982, the BSAI FMP, and other applicable law.

QUEST: Qualifying Environmentally Sustainable Technologies

NASA Technical Reports Server (NTRS)

2006-01-01

Over the years, pollution prevention has proven to be a means to comply with environmental regulations, improve product performance and reduce costs. The NASA Acquisition Pollution Prevention (AP2) Program was created to help individual NASA Centers and programs work together to evaluate and adopt environmentally preferable technologies and practices. The AP2 Program accomplishes its mission using a variety of tools such as networking, information/technology exchange and partnering. Due to its extensive network of contacts, the AP2 Program is an excellent resource for finding existing solutions to problems. If no solution is readily known, the AP2 Program works to identify potential solutions and partners for demonstration/ validation projects. Partnering to prevent pollution is a cornerstone of NASA's prime mission and the One NASA Initiative. This annual newsletter highlights some of our program's collaborative efforts. I believe you will discover how the AP2 Program is responsive in meeting the Agency's environmental management strategic plans.

Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

PubMed

Wang, Lixin; Brugge, Joan S; Janes, Kevin A

2011-10-04

Gene expression networks are complicated by the assortment of regulatory factors that bind DNA and modulate transcription combinatorially. Single-cell measurements can reveal biological mechanisms hidden by population averages, but their value has not been fully explored in the context of mRNA regulation. Here, we adapted a single-cell expression profiling technique to examine the gene expression program downstream of Forkhead box O (FOXO) transcription factors during 3D breast epithelial acinar morphogenesis. By analyzing patterns of mRNA fluctuations among individual matrix-attached epithelial cells, we found that a subset of FOXO target genes was jointly regulated by the transcription factor Runt-related transcription factor 1 (RUNX1). Knockdown of RUNX1 causes hyperproliferation and abnormal morphogenesis, both of which require normal FOXO function. Down-regulating RUNX1 and FOXOs simultaneously causes widespread oxidative stress, which arrests proliferation and restores normal acinar morphology. In hormone-negative breast cancers lacking human epidermal growth factor receptor 2 (HER2) amplification, we find that RUNX1 down-regulation is strongly associated with up-regulation of FOXO1, which may be required to support growth of RUNX1-negative tumors. The coordinate function of these two tumor suppressors may provide a failsafe mechanism that inhibits cancer progression.

Police department personnel stress resilience training: an institutional case study.

PubMed

Weltman, Gershon; Lamon, Jonathan; Freedy, Elan; Chartrand, Donald

2014-03-01

The objective of this case study was to test the impact in law enforcement personnel of an innovative self-regulation and resilience building program delivered via an iPad (Apple Inc, Cupertino, California) app and personal mentoring. The Stress Resilience Training System (SRTS) app includes training on stress and its effects, HRV coherence biofeedback, a series of HeartMath self-regulation techniques (The Institute of HeartMath, Boulder Creek, California), and HRV-controlled games. The stressful nature of law enforcement work is well established, and the need for meaningful and effective stress resilience training programs is becoming better understood, as it has been in the military. Law enforcement and military service share many stress-related features including psychological stressors connected with the mission, extended duty cycles, and exposure to horrific scenes of death and injury. San Diego (California) Police Department personnel who participated in the study were 12 sworn officers and 2 dispatchers, 10 men and 4 women. The SRTS intervention comprised an introductory 2-hour training session, 6 weeks of individualized learning and practice with the SRTS app, and four 1-hour telephone mentoring sessions by experienced HeartMath mentors spread over a four week period. Outcome measures were the Personal and Organizational Quality Assessment (POQA) survey, the mentors' reports of their observations, and records of participants' comments from the mentoring sessions. The POQA results were overwhelmingly positive: All four main scales showed improvement; Emotional Vitality improved by 25% (P=.05) and Physical Stress improved by 24% (P=.01). Eight of the nine subscales showed improvement, with the Stress subscale, perhaps the key measure of the study, improving by approximately 40% (P=.06). Participant responses were also uniformly positive and enthusiastic. Individual participants praised the program and related improvements in both on-the-job performance and personal and familial situations. The results support the efficacy of the program to achieve its goal of building stress resilience and improving officer wellness by providing practical self-regulation skills for better management of emotional energy. We conclude that the SRTS program for building resilience and improving psychological wellness can be as effective for law enforcement as it is for military personnel.

Police Department Personnel Stress Resilience Training: An Institutional Case Study

PubMed Central

Lamon, Jonathan; Freedy, Elan; Chartrand, Donald

2014-01-01

The objective of this case study was to test the impact in law enforcement personnel of an innovative self-regulation and resilience building program delivered via an iPad (Apple Inc, Cupertino, California) app and personal mentoring. The Stress Resilience Training System (SRTS) app includes training on stress and its effects, HRV coherence biofeedback, a series of HeartMath self-regulation techniques (The Institute of HeartMath, Boulder Creek, California), and HRV-controlled games. The stressful nature of law enforcement work is well established, and the need for meaningful and effective stress resilience training programs is becoming better understood, as it has been in the military. Law enforcement and military service share many stress-related features including psychological stressors connected with the mission, extended duty cycles, and exposure to horrific scenes of death and injury. San Diego (California) Police Department personnel who participated in the study were 12 sworn officers and 2 dispatchers, 10 men and 4 women. The SRTS intervention comprised an introductory 2-hour training session, 6 weeks of individualized learning and practice with the SRTS app, and four 1-hour telephone mentoring sessions by experienced HeartMath mentors spread over a four week period. Outcome measures were the Personal and Organizational Quality Assessment (POQA) survey, the mentors' reports of their observations, and records of participants' comments from the mentoring sessions. The POQA results were overwhelmingly positive: All four main scales showed improvement; Emotional Vitality improved by 25% (P=.05) and Physical Stress improved by 24% (P=.01). Eight of the nine subscales showed improvement, with the Stress subscale, perhaps the key measure of the study, improving by approximately 40% (P=.06). Participant responses were also uniformly positive and enthusiastic. Individual participants praised the program and related improvements in both on-the-job performance and personal and familial situations. The results support the efficacy of the program to achieve its goal of building stress resilience and improving officer wellness by providing practical self-regulation skills for better management of emotional energy. We conclude that the SRTS program for building resilience and improving psychological wellness can be as effective for law enforcement as it is for military personnel. PMID:24808985

The Impact of Experienced Emotion on Evaluative Judgments: The Effects of Age and Emotion Regulation Style

PubMed Central

Hess, Thomas M.; Beale, Karen S.; Miles, Amanda

2012-01-01

Adults aged from 24 to 79 were exposed to four commercial advertisements within the context of television programs designed to induce either a positive or negative mood. Although age was associated with memory for the content of the commercials, it did not moderate the impact of mood on evaluations of the advertized products. Instead, participants who reported engaging in expressive suppression as a common emotion regulation strategy were more likely to make evaluations that were biased by moods than those individuals who reported low use of this strategy. The results suggest that the maintenance of emotion regulation ability in later adulthood may help people control certain affective influences on thought. PMID:20694860

Neonatal corticosterone administration in rodents as a tool to investigate the maternal programming of emotional and immune domains.

PubMed

Macrì, Simone

2017-02-01

Neonatal experiences exert persistent influences on individual development. These influences encompass numerous domains including emotion, cognition, reactivity to external stressors and immunity. The comprehensive nature of the neonatal programming of individual phenotype is reverberated in the large amount of experimental data collected by many authors in several scientific fields: biomedicine, evolutionary and molecular biology. These data support the view that variations in precocious environmental conditions may calibrate the individual phenotype at many different levels. Environmental influences have been traditionally addressed through experimental paradigms entailing the modification of the neonatal environment and the multifactorial (e.g. behaviour, endocrinology, cellular and molecular biology) analysis of the developing individual's phenotype. These protocols suggested that the role of the mother in mediating the offspring's phenotype is often associated with the short-term effects of environmental manipulations on dam's physiology. Specifically, environmental manipulations may induce fluctuations in maternal corticosteroids (corticosterone in rodents) which, in turn, are translated to the offspring through lactation. Herein, I propose that this mother-offspring transfer mechanism can be leveraged to devise experimental protocols based on the exogenous administration of corticosterone during lactation. To support this proposition, I refer to a series of studies in which these protocols have been adopted to investigate the neonatal programming of individual phenotype at the level of emotional and immune regulations. While these paradigms cannot replace traditional studies, I suggest that they can be considered a valid complement.

Repetitive elements dynamics in cell identity programming, maintenance and disease.

PubMed

Bodega, Beatrice; Orlando, Valerio

2014-12-01

The days of 'junk DNA' seem to be over. The rapid progress of genomics technologies has been unveiling unexpected mechanisms by which repetitive DNA and in particular transposable elements (TEs) have evolved, becoming key issues in understanding genome structure and function. Indeed, rather than 'parasites', recent findings strongly suggest that TEs may have a positive function by contributing to tissue specific transcriptional programs, in particular as enhancer-like elements and/or modules for regulation of higher order chromatin structure. Further, it appears that during development and aging genomes experience several waves of TEs activation, and this contributes to individual genome shaping during lifetime. Interestingly, TEs activity is major target of epigenomic regulation. These findings are shedding new light on the genome-phenotype relationship and set the premises to help to explain complex disease manifestation, as consequence of TEs activity deregulation. Copyright © 2014. Published by Elsevier Ltd.

Determinants of aggressive behavior: Interactive effects of emotional regulation and inhibitory control.

PubMed

Hsieh, I-Ju; Chen, Yung Y

2017-01-01

Aggressive behavior can be defined as any behavior intended to hurt another person, and it is associated with many individual and social factors. This study examined the relationship between emotional regulation and inhibitory control in predicting aggressive behavior. Seventy-eight participants (40 males) completed self-report measures (Negative Mood Regulation Scale and Buss-Perry Aggression Questionnaire), a stop signal task, and engaged in a modified version of Taylor Aggression Paradigm (TAP) exercise, in which the outcome was used as a measure of direct physical aggression. We used a hierarchical, mixed-model multiple regression analysis test to examine the effects of emotion regulation and inhibitory control on physical reactive aggression. Results indicated an interaction between emotion regulation and inhibitory control on aggression. For participants with low inhibitory control only, there was a significant difference between high and low emotion regulation on aggression, such that low emotion regulation participants registered higher aggression than high emotion regulation participants. This difference was not found among participants with high inhibitory control. These results have implications for refining and targeting training and rehabilitation programs aimed at reducing aggressive behavior.

Employee health surveillance in the health care industry.

PubMed

Hood, Joyce; Larrañaga, Michael

2007-10-01

This article provides an overview of the fundamental and inherent challenges in developing a health surveillance program for a health care facility. These challenges are similar to those facing individuals responsible for developing health surveillance programs for multiple industries because several "mini-industries" exist within hospitals. Hazards can range from those that are regulated by the Occupational Safety and Health Administration to those that are unregulated but pose a threat to health care workers. Occupational hazards that are unique to the health care industry also exist. A health surveillance program can be developed with focused assessment and a strong occupational safety and health program. Implementation can occur within a health care setting with the buy-in of the many stakeholders involved, especially supervisors managing departments where chemical and other hazards are present.

Doping control analyses in horseracing: a clinician's guide.

PubMed

Wong, Jenny K Y; Wan, Terence S M

2014-04-01

Doping(1) in sports is highly detrimental, not only to the athletes involved but to the sport itself as well as to the confidence of the spectators and other participants. To protect the integrity of any sport, there must be in place an effective doping control program. In human sports, a 'top-down' and generally unified approach is taken where the rules and regulations against doping for the majority of elite sport events held in any country are governed by the World Anti-Doping Agency (WADA). However, in horseracing, there is no single organisation regulating this form of equestrian sport; instead, the rules and regulations are provided by individual racing authorities and so huge variations exist in the doping control programs currently in force around the world. This review summarises the current status of doping control analyses in horseracing, from sample collection, to the analyses of the samples, and to the need for harmonisation as well as exploring some of the difficulties currently faced by racing authorities, racing chemists and regulatory veterinarians worldwide. Copyright © 2014 Elsevier Ltd. All rights reserved.

TRICARE program; clarification of benefit coverage of durable equipment and ordering or prescribing durable equipment; clarification of benefit coverage of assistive technology devises under the Extended Care Health Option Program. Final rule.

PubMed

2014-12-31

This final rule modifies the TRICARE regulation to add a definition of assistive technology (AT) devices for purposes of benefit coverage under the TRICARE Extended Care Health Option (ECHO) Program and to amend the definitions of durable equipment (DE) and durable medical equipment (DME) to better conform the language in the regulation to the statute. The final rule amends the language that specifically limits ordering or prescribing of DME to only a physician under the Basic Program, as this amendment will allow certain other TRICARE authorized individual professional providers, acting within the scope of their licensure, to order or prescribe DME. This final rule also incorporates a policy clarification relating to luxury, deluxe, or immaterial features of equipment or devices. That is, TRICARE cannot reimburse for the luxury, deluxe, or immaterial features of equipment or devices, but can reimburse for the base or basic equipment or device that meet the beneficiary's needs. Beneficiaries may choose to pay the provider for the luxury, deluxe, or immaterial features if they desire their equipment or device to have these "extra features."

HIPAA's Individual Right of Access to Genomic Data: Reconciling Safety and Civil Rights.

PubMed

Evans, Barbara J

2018-01-04

In 2014, the United States granted individuals a right of access to their own laboratory test results, including genomic data. Many observers feel that this right is in tension with regulatory and bioethical standards designed to protect the safety of people who undergo genomic testing. This commentary attributes this tension to growing pains within an expanding federal regulatory program for genetic and genomic testing. The Genetic Information Nondiscrimination Act of 2008 expanded the regulatory agenda to encompass civil rights and consumer safety. The individual access right, as it applies to genomic data, is best understood as a civil-rights regulation. Competing regulatory objectives-safety and civil rights-were not successfully integrated during the initial rollout of genomic civil-rights regulations after 2008. Federal law clarifies how to prioritize safety and civil rights when the two come into conflict, although with careful policy design, the two need not collide. This commentary opens a dialog about possible solutions to advance safety and civil rights together. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

A Summary of the United States Food and Drug Administrations’ Food Safety Program for Imported Seafood; One Country’s Approach

PubMed Central

Koonse, Brett

2016-01-01

It is well known that the vast majority of seafood is captured or farmed in emerging countries and exported to developed countries. This has resulted in seafood being the number one traded food commodity in the world. Food safety is essential to this trade. Exporting countries should understand the regulatory food safety programs of the countries they ship to in order to comply with their applicable laws and regulations to avoid violations and disruptions in trade. The United States (U.S.) imports more seafood than any individual country in the world but the European Union (E.U.) countries, as a block, import significantly more. Each importing country has its own programs and systems in place to ensure the safety of imported seafood. However, most countries that export seafood have regulatory programs in place that comply with the import requirements of the E.U. The purpose of this paper is to describe the United States Food and Drug Administration’s (USFDA) imported seafood safety program. The primary audience for the information is foreign government regulators, seafood exporters, and U.S. importers. It can also give consumers confidence that f U.S. seafood is safe no matter which country it originates from. PMID:28231127

Prenatal programming of emotion regulation: neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels.

PubMed

Bolten, Margarete; Nast, Irina; Skrundz, Marta; Stadler, Christina; Hellhammer, Dirk H; Meinlschmidt, Gunther

2013-10-01

Hypothalamic-pituitary-adrenal (HPA) activation during pregnancy is linked to dysfunctional behavioral outcomes in the offspring. According to Belsky's differential susceptibility hypothesis, individuals vary regarding their developmental plasticity. Translating the differential susceptibility hypothesis to the field of fetal programming, we hypothesize that infants' temperament, as the constitutionally based reactivity to stimulation, moderates prenatal environmental effects on postnatal emotion regulation. Maternal HPA axis activity and stress-reactivity during pregnancy was estimated, by measuring cortisol concentrations in saliva, collected at 0, 30, 45 and 60 min after awakening and in blood, collected during a laboratory stress test (Trier Social Stress Test), respectively. Newborns reactivity to stimulation was evaluated between postnatal day 10 and 14 using the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Infant's self-quieting-activities, as an indicator of emotion regulation, were evaluated at the age of six months during the still face paradigm. Maternal cortisol reactivity to stress during pregnancy was associated with infant's emotion regulation at the age of six months. Whereas cortisol levels after awakening in mid and late pregnancy were not associated with emotion regulation. Furthermore, regression analyses revealed that in interaction with neonatal reactivity, both, prenatal maternal HPA activity as well as prenatal maternal HPA reactivity to stress predicted emotion regulation. The findings indicate that newborns' reactivity to stimulation is moderating the association between prenatal exposure to maternal glucocorticoids and emotion regulation in infancy. Data suggests that temperamental characteristics of the newborn are a relevant differential susceptibility factor with regard to prenatal effects on emotion regulation. © 2013.

48 CFR 1.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Individual deviations. 1.403 Section 1.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.403 Individual deviations. Individual...

48 CFR 1.403 - Individual deviations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Individual deviations. 1.403 Section 1.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.403 Individual deviations. Individual...

48 CFR 1.403 - Individual deviations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Individual deviations. 1.403 Section 1.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.403 Individual deviations. Individual...

48 CFR 3401.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Individual deviations. 3401.403 Section 3401.403 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL ED ACQUISITION REGULATION SYSTEM Deviations 3401.403 Individual deviations. An individual...

Surgery program directors' knowledge of opioid prescribing regulations: a survey study.

PubMed

Yorkgitis, Brian K; Raygor, Desiree; Bryant, Elizabeth; Brat, Gabriel; Smink, Douglas S; Crandall, Marie

2018-07-01

Opioid misuse is a public health crisis that stems in part from overprescribing by health-care providers. Surgical residents are commonly responsible for prescribing opioids at patient discharge, and residency program directors (PDs) are charged with their residents' education. Because each hospital and state has different opioid prescribing policies, we sought to assess PDs' knowledge about local controlled substance prescribing polices. A survey was emailed to surgery PDs that included questions regarding residency characteristics and knowledge of state regulations. A total of 247 PDs were emailed with 110 (44.5%) completed responses. One hundred and four (94.5%) allow residents to prescribe outpatient opioids; one was unsure. Sixty-three (57.3%) respondents correctly answered if their state required opioid prescribing education for full licensure. Twenty-two (20.0%) were unsure if their state required opioid prescribing education for licensure. Sixty-four (58.2%) respondents answered correctly if a prescription monitor programs use is required in their state. Twenty-nine (26.4%) were unsure if a state prescription monitor programs existed. Seventy-six (69.1%) PDs answered correctly about their state's requirement for an additional registration to prescribe controlled substances; 10 (9.1%) did not know if this was required. Twenty-nine (27.9%) programs require residents to obtain individual drug enforcement agency registration; 5 (4.8%) were unsure if this was required. Most programs allow residents to prescribe outpatient opioids. However, this survey demonstrated a considerable gap in PDs' knowledge about controlled substance regulations. Because they oversee surgical residents' education, PDs should be versed about their local policies in this matter. Copyright © 2018 Elsevier Inc. All rights reserved.

Making Healthy Choices Easier: Regulation versus Nudging.

PubMed

Hansen, Pelle Guldborg; Skov, Laurits Rohden; Skov, Katrine Lund

2016-01-01

In recent years, the nudge approach to behavior change has emerged from the behavioral sciences to challenge the traditional use of regulation in public health strategies to address modifiable individual-level behaviors related to the rise of noncommunicable diseases and their treatment. However, integration and testing of the nudge approach as part of more comprehensive public health strategies aimed at making healthy choices easier are being threatened by inadequate understandings of its scientific character, its relationship with regulation, and its ethical implications. This article reviews this character and its ethical implication with a special emphasis on the compatibility of nudging with traditional regulation, special domains of experience, and the need for a more nuanced approach to the ethical debate. The aim is to advance readers' understanding and give guidance to those who have considered working with or incorporating the nudge approach into programs or policies aimed at making healthful choices easier.

From the Paralympics to public health: increasing physical activity through legislative and policy initiatives.

PubMed

Blauwet, Cheri A; Iezzoni, Lisa I

2014-08-01

Individuals with disabilities experience a disproportionate rate of chronic disease and are more likely to lead sedentary lifestyles than the general population. Multiple complex factors likely contribute to these disparities, including structural, socioeconomic and attitudinal barriers that impede broad participation of individuals with disabilities in health and wellness promotion programs. Public health initiatives aimed at mitigating these health disparities emphasize improved access to physical activity and sports opportunities. Given its visibility, the Paralympic Movement provides an opportunity to transform how society conceptualizes the relationship of disability to physical fitness. The Paralympics also serve as a catalyst for public health education and program development. Already, public policies and governmental regulations are expanding grassroots sports opportunities for youth and adults with disabilities, thus promoting inclusive opportunities for participation in physical activity. Copyright © 2014 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Nurse-midwives in federally funded health centers: understanding federal program requirements and benefits.

PubMed

Carter, Martha

2012-01-01

Midwives are working in federally funded health centers in increasing numbers. Health centers provide primary and preventive health care to almost 20 million people and are located in every US state and territory. While health centers serve the entire community, they also serve as a safety net for low-income and uninsured individuals. In 2010, 93% of health center patients had incomes below 200% of the Federal Poverty Guidelines, and 38% were uninsured. Health centers, including community health centers, migrant health centers, health care for the homeless programs, and public housing primary care programs, receive grant funding and enjoy other benefits due to status as federal grantees and designation as federally qualified health centers. Clinicians working in health centers are also eligible for financial and professional benefits because of their willingness to serve vulnerable populations and work in underserved areas. Midwives, midwifery students, and faculty working in, or interacting with, health centers need to be aware of the regulations that health centers must comply with in order to qualify for and maintain federal funding. This article provides an overview of health center regulations and policies affecting midwives, including health center program requirements, scope of project policy, provider credentialing and privileging, Federal Tort Claims Act malpractice coverage, the 340B Drug Pricing Program, and National Health Service Corps scholarship and loan repayment programs. © 2012 by the American College of Nurse-Midwives.

Appetite self-regulation: Environmental and policy influences on eating behaviors.

PubMed

Schwartz, Marlene B; Just, David R; Chriqui, Jamie F; Ammerman, Alice S

2017-03-01

Appetite regulation is influenced by the environment, and the environment is shaped by food-related policies. This review summarizes the environment and policy research portion of an NIH Workshop (Bethesda, MD, 2015) titled "Self-Regulation of Appetite-It's Complicated." In this paper, we begin by making the case for why policy is an important tool in efforts to improve nutrition, and we introduce an ecological framework that illustrates the multiple layers that influence what people eat. We describe the state of the science on how policies influence behavior in several key areas: the federal food programs, schools, child care, food and beverage pricing, marketing to youth, behavioral economics, and changing defaults. Next, we propose novel approaches for multidisciplinary prevention and intervention strategies to promote breastfeeding, and examine interactions between psychology and the environment. Policy and environmental change are the most distal influences on individual-level appetite regulation, yet these strategies can reach many people at once by changing the environment in which food choices are made. We note the need for more research to understand compensatory behavior, reactance, and how to effectively change social norms. To move forward, we need a more sophisticated understanding of how individual psychological and biological factors interact with the environment and policy influences. © 2017 The Obesity Society.

Effects of the comprehensive cardiac rehabilitation program on psychological factors and quality of life among coronary heart disease patients.

PubMed

Intarakamhang, Patrawut; Intarakamhang, Ungsinun

2012-12-24

The Comprehensive Lifestyle Intervention, which integrates psychological and educational intervention, is a program to improve self-efficacy, self-regulation, self-care, body mass index and quality of life of the patients with coronary heart disease during early stages following hospitalization. The purpose of this study was to investigate the effects of the Comprehensive Cardiac Rehabilitation Program affecting psychological factors including self-efficacy, self-regulation, self-care, quality of life (QoL), and body mass index (BMI). This study was a quasi-experimental research with a repeated one group design. Eighty patients with coronary artery disease were recruited from either the Medicine or Surgical Ward at the Phramongkutklao Hospital where the patients joined the Comprehensive Cardiac Rehabilitation Program, which included attending exercising practice and receiving face-to-face counseling while being admitted to the hospital. Telephone counseling was thereafter performed one week after being discharged from the hospital, followed by undergoing individual or group counseling at the Cardiac Rehabilitation Clinic the following week. The follow-up period was performed within six weeks after hospitalization. Data was collected on two occasions before discharging from the hospital (pretest) and six weeks after (post-test) by using the self-efficacy, self-regulation, and self-care questionnaires, as well as the Short Form(SF) -36 (Thai version). The results indicated that by six weeks, 50%, 58.80%, 46.20%, and 72.50% of patients, respectively, had experienced increases with self-efficacy, self-regulation, self-care, and quality of life scores, while 12.50% of patients had decreased their body mass index in comparison with the pretest score. From the paired t-test, the self-efficacy, self-regulation and quality of life scores were statistically significant, having increased to the p<0.01 level; self-care was statistically significant, having increased to the p<0.05 level along with body mass index, which was statistically significant having experienced a decrease to the p<0.01 level.

Adipose tissue CIDEA is associated, independently of weight variation, to change in insulin resistance during a longitudinal weight control dietary program in obese individuals.

PubMed

Montastier, Emilie; Déjean, Sébastien; Le Gall, Caroline; Saris, Wim H M; Langin, Dominique; Viguerie, Nathalie

2014-01-01

Weight loss reduces risk factors associated with obesity. However, long-term metabolic improvement remains a challenge. We investigated quantitative gene expression of subcutaneous adipose tissue in obese individuals and its relationship with low calorie diet and long term weight maintenance induced changes in insulin resistance. Three hundred eleven overweight and obese individuals followed a dietary protocol consisting of an 8-week low calorie diet followed by a 6-month ad libitum weight-maintenance diet. Individuals were clustered according to insulin resistance trajectories assessed using homeostasis model assessment of insulin resistance (HOMA-IR) index. Adipose tissue mRNA levels of 267 genes selected for regulation according to obesity, metabolic status and response to dieting was assessed using high throughput RT-qPCR. A combination of discriminant analyses was used to identify genes with regulation according to insulin resistance trajectories. Partial correlation was used to control for change in body mass index. Three different HOMA-IR profile groups were determined. HOMA-IR improved during low calorie diet in the 3 groups. At the end of the 6-month follow-up, groups A and B had reduced HOMA-IR by 50%. In group C, HOMA-IR had returned to baseline values. Genes were differentially expressed in the adipose tissue of individuals according to groups but a single gene, CIDEA, was common to all phases of the dietary intervention. Changes in adipose tissue CIDEA mRNA levels paralleled variations in insulin sensitivity independently of change in body mass index. Overall, CIDEA was up-regulated in adipose tissue of individuals with successful long term insulin resistance relapse and not in adipose tissue of unsuccessful individuals. The concomitant change in adipose tissue CIDEA mRNA levels and insulin sensitivity suggests a beneficial role of adipose tissue CIDEA in long term glucose homeostasis, independently of weight variation. ClinicalTrials.gov NCT00390637.

Societal Influences on Health and Life-styles

PubMed Central

Ulmer, David D.

1984-01-01

Strong sociocultural forces affect individual attitudes toward health and choice of life-style. Economic deprivation fosters negative health behaviors. Positive health habits are reinforced by discrete societal groups. The news media, particularly television, disseminate much useful health information, though the overall educational value is diminished by the content of commercial messages and programming. The automobile is a major societal influence, but neither individual drivers nor the car manufacturers give enough priority to highway safety, leaving that role to governmental regulation. American industry is becoming a positive influence in the encouragement of good health habits, and fashion is lately an important ally in personal health maintenance. PMID:6523860

Behind the wheel: community consultation informs adaptation of safe-transport program for older drivers.

PubMed

Coxon, Kristy; Keay, Lisa

2015-12-09

Safe-transport is important to well-being in later life but balancing safety and independence for older drivers can be challenging. While self-regulation is a promising tool to promote road safety, more research is required to optimise programs. Qualitative research was used to inform the choice and adaptation of a safe-transport education program for older drivers. Three focus groups were conducted with older drivers living in northwest Sydney to explore four key areas related to driving in later life including aged-based licensing, stopping or limiting driving, barriers to driving cessation and alternative modes of transportation. Data were analysed using content analysis. Four categories emerged from the data; bad press for older drivers, COMPETENCE not age, call for fairness in licensing regulations, and hanging up the keys: It's complicated! Two key issues being (1) older drivers wanted to drive for as long as possible but (2) were not prepared for driving cessation; guided the choice and adaption of the Knowledge Enhances Your Safety (KEYS) program. This program was adapted for the Australian context and focus group findings raised the need for practical solutions, including transport alternatives, to be added. Targeted messages were developed from the data using the Precaution Adoption Process Model (PAPM), allowing the education to be tailored to the individual's stage of behaviour change. Adapting our program based on insights gained from community consultation should ensure the program is sensitive to the needs, skills and preferences of older drivers.

Regulating a health insurance exchange: implications for individuals with mental illness.

PubMed

McGuire, Thomas G; Sinaiko, Anna D

2010-11-01

Under the newly enacted health reform law, millions of lower- and middle-income Americans will purchase individual or family health insurance through state-based markets for private health insurance called insurance "exchanges," which consolidate and regulate the market for individual and small-group health insurance. The authors consider options for structuring choice and pricing of health insurance in an exchange from the perspective of efficiently and fairly serving persons with mental illness. Exchanges are intended to foster choice and competition. However, certain features-open enrollment, individual choice, and imperfect risk adjusters-create incentives for "adverse selection," especially in providing coverage for persons with mental illness, who have higher overall health care costs. The authors review the experience of persons with mental illness in insurance markets similar to the exchanges, such as the Massachusetts Connector and the Federal Employees Health Benefit Program, and note that competition among health plans for enrollees who are "good risks" can undermine coverage and efficiency. They review the possible approaches for contending with selection-related incentives, such as carving out all or part of mental health benefits, providing reinsurance for some mental health care costs, or their preferred option, running the exchange in the same way that an employer runs its employee benefits and addressing selection and cost control issues by choice of contractor. The authors also consider approaches an exchange could use to promote effective consumer choice, such as passive and active roles for the exchange authority. Regulation will be necessary to establish a foundation for success of the exchanges.

Depression vulnerable and nonvulnerable smokers after a failure experience: examining cognitive self-regulation and motivation.

PubMed

Scott, Walter D; Beevers, Christopher G; Mermelstein, Robin J

2008-07-01

The present study extended previous tests of cognitive priming theories of depression by examining cognitive self-regulatory, motivational, and affective functioning of depression-vulnerable and nonvulnerable individuals after a failure experience. Participants were enrolled in a clinic-based smoking cessation program that consisted of seven group meetings. Major findings show that compared to the nonvulnerable group, depression-vulnerable individuals were less motivated to quit and experienced more negative affect, but only after a failure to quit smoking. However, after controlling for actual smoking rate, depression-vulnerable individuals did not evaluate their success any more negatively, nor did they indicate lower self-efficacy for quitting. Results are discussed in terms of cognitive self-regulatory and affect temperament models of motivation and depression.

Aging As An Evolvability-Increasing Program Which Can Be Switched Off By Organism To Mobilize Additional Resources For Survival.

PubMed

Skulachev, Maxim V; Severin, Fedor F; Skulachev, Vladimir P

2015-04-22

During the last decade, several pieces of convincing evidence were published indicating that aging of living organisms is programmed, being a particular case of programmed death of organism (phenoptosis). Among them, the following observations can be mentioned [1]. Species were described that show negligible aging. In mammals, the naked mole rat is the most impressive example. This is a rodent of mouse size living at least 10-fold longer than a mouse and having fecundity higher than a mouse and no age-related diseases [2]. In some species with high aging rate, genes responsible for active organization of aging by poisoning of the organism with endogenous metabolites have been identified [3]. In women, standard deviations divided by the mean are the same for age of menarche (an event controlled by the ontogenetic program) and for age of menopause (an aging-related event) [4]. Inhibitors of programmed cell death (apoptosis and necrosis) retard and in certain cases even reverse the development of age-dependent pathologies [5]. In aging species, the rate of aging is regulated by the individual which responds by changes in this rate to changes in the environmental conditions. In this review, we consider point [5] in detail. Data are summarized suggesting that inhibition of aging rate by moderate food restriction can be explained assuming that such restriction is perceived by the organism as a signal of future starvation. In response to this dramatic signal, the organism switches off such an optional program as aging, mobilizing in such a way additional reserves for survival. A similar explanation is postulated for geroprotective effects of heavy muscle work, a lowering or a rise in the external temperature, small amounts of metabolic poisons (hormesis), low doses of radiation, and other deleterious events. On the contrary, sometimes certain positive signals can prolong life by inhibiting the aging program in individuals who are useful for the community (e.g., geroprotective psychological factors). Similarly, dangerous individuals can be eliminated by programmed death due to operation of progeric psychological factors. The interplay of all these signals results in the final decision of the organism concerning its aging - to accelerate or to decelerate this process. Thus, paradoxically, such an originally counterproductive program as aging appears to be useful for the individual since this program can be switched off by the individual for a certain period of time, an action that thereby increases its resources in crucial periods of life.

Aging as an evolvability-increasing program which can be switched off by organism to mobilize additional resources for survival.

PubMed

Skulachev, Maxim V; Severin, Fedor F; Skulachev, Vladimir P

2015-01-01

During the last decade, several pieces of convincing evidence were published indicating that aging of living organisms is programmed, being a particular case of programmed death of organism (phenoptosis). Among them, the following observations can be mentioned. (1) Species were described that show negligible aging. In mammals, the naked mole rat is the most impressive example. This is a rodent of mouse size living at least 10-fold longer than a mouse and having fecundity higher than a mouse and no agerelated diseases. (2) In some species with high aging rate, genes responsible for active organization of aging by poisoning of the organism with endogenous metabolites have been identified. (3) In women, standard deviations divided by the mean are the same for age of menarche (an event controlled by the ontogenetic program) and for age of menopause (an aging-related event). (4) Inhibitors of programmed cell death (apoptosis and necrosis) retard and in certain cases even reverse the development of age-dependent pathologies. (5) In aging species, the rate of aging is regulated by the individual which responds by changes in this rate to changes in the environmental conditions. In this review, we consider point (5) in detail. Data are summarized suggesting that inhibition of aging rate by moderate food restriction can be explained assuming that such restriction is perceived by the organism as a signal of future starvation. In response to this dramatic signal, the organism switches off such an optional program as aging, mobilizing in such a way additional reserves for survival. A similar explanation is postulated for geroprotective effects of heavy muscle work, a lowering or a rise in the external temperature, small amounts of metabolic poisons (hormesis), low doses of radiation, and other deleterious events. On the contrary, sometimes certain positive signals can prolong life by inhibiting the aging program in individuals who are useful for the community (e.g., geroprotective psychological factors). Similarly, dangerous individuals can be eliminated by programmed death due to operation of progeric psychological factors. The interplay of all these signals results in the final decision of the organism concerning its aging - to accelerate or to decelerate this process. Thus, paradoxically, such an originally counterproductive program as aging appears to be useful for the individual since this program can be switched off by the individual for a certain period of time, an action that thereby increases its resources in crucial periods of life.

Retinal Determination genes function along with cell-cell signals to regulate Drosophila eye development: examples of multi-layered regulation by Master Regulators

PubMed Central

Baker, Nicholas E.; Firth, Lucy C.

2015-01-01

It is thought that Retinal Determination gene products define the response made to cell-cell signals within the eye developmental field by binding to enhancers of genes that are also regulated by cell-cell signaling pathways. In Drosophila, Retinal Determination genes including Eyeless, teashirt, eyes absent, dachsous and sine oculis, are required for normal eye development and can induce ectopic eyes when mis-expressed. Characterization of the enhancers responsible for eye expression of the hedgehog, shaven, and atonal genes, as well as the dynamics of Retinal Determination gene expression themselves, now suggest a multilayered network whereby transcriptional regulation by either Retinal Determination genes or cell-cell signaling pathways can sometimes be indirect and mediated by other transcription factor intermediates. In this updated view of the interaction between extracellular information and cell intrinsic programs during development, regulation of individual genes might sometimes be several steps removed from either the Retinal Determination genes or cell-cell signaling pathways that nevertheless govern their expression. PMID:21607995

Medicaid Program; Disproportionate Share Hospital Payments--Treatment of Third Party Payers in Calculating Uncompensated Care Costs. Final rule.

PubMed

2017-04-03

This final rule addresses the hospital-specific limitation on Medicaid disproportionate share hospital (DSH) payments under section 1923(g)(1)(A) of the Social Security Act (Act), and the application of such limitation in the annual DSH audits required under section 1923(j) of the Act, by clarifying that the hospital-specific DSH limit is based only on uncompensated care costs. Specifically, this rule makes explicit in the text of the regulation, an existing interpretation that uncompensated care costs include only those costs for Medicaid eligible individuals that remain after accounting for payments made to hospitals by or on behalf of Medicaid eligible individuals, including Medicare and other third party payments that compensate the hospitals for care furnished to such individuals. As a result, the hospital-specific limit calculation will reflect only the costs for Medicaid eligible individuals for which the hospital has not received payment from any source.

34 CFR 389.3 - What regulations apply to this program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What regulations apply to this program? 389.3 Section 389.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... PROGRAMS General § 389.3 What regulations apply to this program? The following regulations apply to this...

34 CFR 389.3 - What regulations apply to this program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true What regulations apply to this program? 389.3 Section 389.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... PROGRAMS General § 389.3 What regulations apply to this program? The following regulations apply to this...

48 CFR 2501.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations. Individual...

Television and families: what do young children watch with their parents?

PubMed

St Peters, M; Fitch, M; Huston, A C; Wright, J C; Eakins, D J

1991-12-01

A sample of 271 3- and 5-year-olds and their families participated in a 2-year longitudinal study of television viewing patterns. 5 1-week diaries for all family members were collected at 6-month intervals. Programs were categorized as: (1) child informative, (2) child entertainment, (3) news and informative, (4) sports, (5) comedy, (6) drama, (7) action-adventure, and (8) variety-game. The majority of child programs were viewed without parents, while the majority of adult programs were watched with parents. Coviewing patterns of adult programs were predicted from parents' individual viewing habits, but not from the child's. Coviewing declined with age. Parental encouragement and regulation of viewing were orthogonal. Children whose parents encouraged viewing watched more child informative programming; children of restrictive parents watched less entertainment programming. Encouraging parents coviewed more than nonencouraging parents. Results support the assertion that parental viewing preferences, habits, and orientations toward television influence children's viewing, both with and without parents.

Passive and hybrid solar technologies program summary

NASA Astrophysics Data System (ADS)

1985-05-01

The goal of the national energy policy is to foster an adequate supply of energy at reasonable prices. This policy recognizes that adequate supply requires flexibility, with no undue reliance on any single source of supply. The goal of reasonable prices suggests economic efficiency so that consumers, individuals, commercial and industrial users alike, are not penalized by government regulation or subside. The strategies for achieving this energy policy goal are: (1) to minimize federal regulation in energy pricing while maintaining public health and safety and environmental quality, and (2) to promote a balanced and mixed energy resource system through research and development. One of the keys to energy sufficiently is the scientific application of passive solar energy techniques.

77 FR 5193 - Retrospective Review Under E.O. 13563: Shipping-Removal of Obsolete Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... Program, which replaced the Operating-Differential Subsidy (ODS) Program. Therefore, the regulations pertaining to the ODS Program and the Construction-Differential (CDS) Program are no longer in use. In... regulations 46 CFR parts 251, 252, 276, 280, 281,282, and 283. The regulations related to the ODS Program are...

Medicaid program; state plan home and community-based services, 5-year period for waivers, provider payment reassignment, and home and community-based setting requirements for Community First Choice and home and community-based services (HCBS) waivers. Final rule.

PubMed

2014-01-16

This final rule amends the Medicaid regulations to define and describe state plan section 1915(i) home and community-based services (HCBS) under the Social Security Act (the Act) amended by the Affordable Care Act. This rule offers states new flexibilities in providing necessary and appropriate services to elderly and disabled populations. This rule describes Medicaid coverage of the optional state plan benefit to furnish home and community based-services and draw federal matching funds. This rule also provides for a 5-year duration for certain demonstration projects or waivers at the discretion of the Secretary, when they provide medical assistance for individuals dually eligible for Medicaid and Medicare benefits, includes payment reassignment provisions because state Medicaid programs often operate as the primary or only payer for the class of practitioners that includes HCBS providers, and amends Medicaid regulations to provide home and community-based setting requirements related to the Affordable Care Act for Community First Choice State plan option. This final rule also makes several important changes to the regulations implementing Medicaid 1915(c) HCBS waivers.

Fourth conference on radiation protection and dosimetry: Proceedings, program, and abstracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casson, W.H.; Thein, C.M.; Bogard, J.S.

This Conference is the fourth in a series of conferences organized by staff members of Oak Ridge National Laboratory in an effort to improve communication in the field of radiation protection and dosimetry. Scientists, regulators, managers, professionals, technologists, and vendors from the United States and countries around the world have taken advantage of this opportunity to meet with their contemporaries and peers in order to exchange information and ideas. The program includes over 100 papers in 9 sessions, plus an additional session for works in progress. Papers are presented in external dosimetry, internal dosimetry, radiation protection programs and assessments, developmentsmore » in instrumentation and materials, environmental and medical applications, and on topics related to standards, accreditation, and calibration. Individual papers are indexed separately on EDB.« less

Influence of antiretroviral therapy on programmed death-1 (CD279) expression on T cells in lymph nodes of human immunodeficiency virus-infected individuals.

PubMed

Ehrhard, Simone; Wernli, Marion; Dürmüller, Ursula; Battegay, Manuel; Gudat, Fred; Erb, Peter

2009-10-01

Human immunodeficiency virus infection leads to T-cell exhaustion and involution of lymphoid tissue. Recently, the programmed death-1 pathway was found to be crucial for virus-specific T-cell exhaustion during human immunodeficiency virus infection. Programmed death-1 expression was elevated on human immunodeficiency virus-specific peripheral blood CD8+ and CD4+ T cells and correlated with disease severity. During human immunodeficiency infection, lymphoid tissue acts as a major viral reservoir and is an important site for viral replication, but it is also essential for regulatory processes important for immune recovery. We compared programmed death-1 expression in 2 consecutive inguinal lymph nodes of 14 patients, excised before antiretroviral therapy (antiretroviral therapy as of 1997-1999) and 16 to 20 months under antiretroviral therapy. In analogy to lymph nodes of human immunodeficiency virus-negative individuals, in all treated patients, the germinal center area decreased, whereas the number of germinal centers did not significantly change. Programmed death-1 expression was mostly found in germinal centers. The absolute extent of programmed death 1 expression per section was not significantly altered after antiretroviral therapy resulting in a significant-relative increase of programmed death 1 per shrunken germinal center. In colocalization studies, CD45R0+ cells that include helper/inducer T cells strongly expressed programmed death-1 before and during therapy, whereas CD8+ T cells, fewer in numbers, showed a weak expression for programmed death-1. Thus, although antiretroviral therapy seems to reduce the number of programmed death-1-positive CD8+ T lymphocytes within germinal centers, it does not down-regulate programmed death-1 expression on the helper/inducer T-cell subset that may remain exhausted and therefore unable to trigger immune recovery.

76 FR 38533 - Alphabetical Listings: Specially Designated Nationals and Blocked Persons; Blocked Vessels...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

...The Department of the Treasury's Office of Foreign Assets Control (``OFAC'') is amending 31 CFR chapter V to replace the list of persons (which includes individuals and entities) with whom transactions and dealings are prohibited by the various economic sanctions programs administered by OFAC that appears at Appendix A to 31 CFR chapter V with information on how to obtain up-to-date lists of such persons on OFAC's Web site or by other means. OFAC also is removing Appendix B to 31 CFR chapter V, which includes the names of certain blocked vessels. In addition, OFAC is amending its regulations for a number of the sanctions programs it administers to revise references to Appendix A and to remove references to Appendix B. Finally, OFAC is amending the Iranian Transactions Regulations, by republishing in alphabetical order the entire list of persons identified in Appendix A to 31 CFR Part 560, to reflect changes to the list since that appendix was last published.

Hanford Site Environmental Report 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dirkes, R.L.; Hanf, R.W.; Woodruff, R.K.

The Hanford Site Environmental Report is prepared annually to summarize environmental data and information, describe environmental management performance, and demonstrate the status of compliance with environmental regulations. The report also highlights major environmental programs and efforts. The report is written to meet reporting requirements and Guidelines of the U.S. Department of Energy (DOE) an to meet the needs of the public. This summary has been written with a minimum of technical terminology. Individual sections of the report are designed to (a) describe the Hanford Site and its mission, (b) summarize the status in 1993 of compliance with environmental regulations, (c)more » describe the environmental programs at the Hanford Site, (d) discuss estimated radionuclide exposure to the public from 1993 Hanford activities, (e) present information on effluent monitoring and environmental surveillance, including ground-water protection and monitoring, (f) discuss activities to ensure quality. More detailed information can be found in the body of the report, the appendixes, and the cited references.« less

48 CFR 201.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Individual deviations. 201.403 Section 201.403 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Individual deviations. (1) Individual deviations, except those described in 201.402(1) and paragraph (2) of...

Insta-grated Plastic Surgery Residencies: The Rise of Social Media Use by Trainees and Responsible Guidelines for Use.

PubMed

Chandawarkar, Akash A; Gould, Daniel J; Stevens, W Grant

2018-02-21

Ethical guidelines for appropriate use of social media are beginning to be delineated. As social media becomes ingrained in plastic surgery culture, education of residents on appropriate use of social media is increasingly important. Recently, plastic surgery residency programs have begun to utilize social media. This study characterizes the trends and content of plastic surgery residency-associated Instagram accounts. Active individual residency program Instagram accounts were identified for integrated plastic surgery programs. Metrics for each account were retrieved on September 16, 2017, including date of first post, number of posts, and followers. Individual posts were analyzed for content of post. Fourteen of 67 (21%) integrated plastic surgery programs were found to have active Instagram accounts. There has been an exponential growth of programs adopting Instagram since August 2015. A total of 806 posts were created. Thirty-two (3.97%) posts had intraoperative photos and only one (0.12%) showed a patient image. There were 4466 followers of plastic surgery residency programs. A linear correlation was found between number of posts and number of followers, while there was no correlation of number of followers and time since account start. Instagram use by plastic surgery integrated programs continues to grow exponentially, and programs are appropriately using the platform. Active use of the resident social media results in increased influence. Resident use of social media has many benefits. We propose social media guidelines for plastic surgery trainees and advocate for continued appropriate use and auto-regulation by plastic surgery trainees.

State of Michigan Special Education State Plan for Fiscal Years 1995-1997 as Fully Approved by the Office of Special Education Programs of the U.S. Department of Education on July 10, 1996.

ERIC Educational Resources Information Center

Michigan State Dept. of Education, Lansing. Office of Special Education and Early Intervention Services.

This report presents the state of Michigan's special education state plan for fiscal years 1995-1997. It includes policies and procedures for complying with the Individuals with Disabilities Education Act (IDEA) and state regulations. Chapters address: (1) the right to education; (2) full educational opportunities, goals, and time lines; (3) child…

Regulation of Breast Cancer Stem Cell by Tissue Rigidity

DTIC Science & Technology

2014-06-01

pose the similar question as Paszek et al but in a more biomimetic niche: “Does the mature mammary acinar structure desensitize mammary epithelial...2728032. 6. Lucero HA, Kagan HM. Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci. 2006;63(19-20):2304-16. 7. Levental...requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating

Science research annual, volume II: a collection of science staff memoranda and letters from the Illinois Legislature Council - January-June 1980. Annual report Jan 80-Sep 81

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dutton, J.A.

This volume contains a collection of correspondence and contributions from the Illinois Legislative Council. The memoranda, which have been organized into research reports, answer requests from individual legislators for information on specific science, technology, and public policy issues, and include information sources and pertinent legislation of the 81st Illinois General Assembly. Topics covered are as follows: abortion information; accidental deer slaughter; regulation of airport noise pollution; historical artifacts preservation; asbestos health hazards; automobile repair legislation; HLA blood tests; financial aid for catastrophic illness; cost comparison of coal and nuclear power; mandates for coroners versus medical examiners; dialysis patient programs; drugmore » paraphernalia legislation; electric generating capacity of Fox River dams; energy efficiency in appliances; euthanasia; farmland preservation; licenses for fish dealers; gasohol definition, grants, and other states' laws; medical precautions at football games; the Ames, Iowa methane plant; metric sales laws; proposed mining regulations; nuclear power referenda; nuclear waste disposal; pharmaceutical assistance and renewable prescriptions for the aged; licensing of radiation device operators; scientific creationism; solar energy grants and loans; funding for solar energy programs; sulfur dioxide standards; and visual aid programs.« less

Relationships among constructivist learning environment perceptions, motivational beliefs, self-regulation and science achievement

NASA Astrophysics Data System (ADS)

Kingir, Sevgi; Tas, Yasemin; Gok, Gulsum; Sungur Vural, Semra

2013-11-01

Background. There are attempts to integrate learning environment research with motivation and self-regulation research that considers social context influences an individual's motivation, self-regulation and, in turn, academic performance. Purpose. This study explored the relationships among constructivist learning environment perception variables (personal relevance, uncertainty, shared control, critical voice, student negotiation), motivational beliefs (self-efficacy, intrinsic interest, goal orientation), self-regulation, and science achievement. Sample. The sample for this study comprised 802 Grade 8 students from 14 public middle schools in a district of Ankara in Turkey. Design and methods. Students were administered 4 instruments: Constructivist Learning Environment Survey, Goal Achievement Questionnaire, Motivated Strategies for Learning Questionnaire, and Science Achievement Test. LISREL 8.7 program with SIMPLIS programming language was used to test the conceptual model. Providing appropriate fit indices for the proposed model, the standardized path coefficients for direct effects were examined. Results. At least one dimension of the constructivist learning environment was associated with students' intrinsic interest, goal orientation, self-efficacy, self-regulation, and science achievement. Self-efficacy emerged as the strongest predictor of both mastery and performance avoidance goals rather than the approach goals. Intrinsic value was found to be significantly linked to science achievement through its effect on self-regulation. The relationships between self-efficacy and self-regulation and between goal orientation and science achievement were not significant. Conclusion. In a classroom environment supporting student autonomy and control, students tend to develop higher interest in tasks, use more self-regulatory strategies, and demonstrate higher academic performance. Science teachers are highly recommended to consider these findings when designing their lessons. For the creation of such a learning environment, teachers can design open-ended inquiry activities in which students have opportunities to take responsibility, reflect on their views, and accomplish challenging tasks.

Medicare and Medicaid Programs; Fire Safety Requirements for Certain Health Care Facilities. Final rule.

PubMed

2016-05-04

This final rule will amend the fire safety standards for Medicare and Medicaid participating hospitals, critical access hospitals (CAHs), long-term care facilities, intermediate care facilities for individuals with intellectual disabilities (ICF-IID), ambulatory surgery centers (ASCs), hospices which provide inpatient services, religious non-medical health care institutions (RNHCIs), and programs of all-inclusive care for the elderly (PACE) facilities. Further, this final rule will adopt the 2012 edition of the Life Safety Code (LSC) and eliminate references in our regulations to all earlier editions of the Life Safety Code. It will also adopt the 2012 edition of the Health Care Facilities Code, with some exceptions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sorensen, Christina M.; Ding, Jie; Zhang, Qibin

Objectives: To characterize the lipid profile of individuals with newly diagnosed type 1 diabetes mellitus using LC-MS-based lipidomics and the accurate mass and time (AMT) tag approach. Design and methods: Lipids were extracted from plasma and sera of 10 subjects from the Diabetes Antibody Standardization Program (years 2000-2005) and 10 non-diabetic subjects and analyzed by capillary liquid chromatography coupled with a hybrid ion-trap-Fourier transform ion cyclotron resonance mass spectrometer. Lipids were identified and quantified using the AMT tag approach. Results: Five hundred sixty lipid features differentiated (q < 0.05) diabetic from healthy individuals in a partial least-squares analysis, characterizing ofmore » individuals with recently diagnosed type 1 diabetes mellitus. Conclusions: A lipid profile associated with newly diagnosed type 1 diabetes may aid in further characterization of biochemical pathways involved in lipid regulation or mobilization and lipotoxicity of pancreatic beta-cells.« less

Addressing Social Anxiety Concurrently With Prison-Based Sex Offender Treatment: A Case of Individual Needs in an Era of Manualized Treatment.

PubMed

Lasher, Michael P; Webb, Jon R; Stinson, Jill D; Cantrell, Peggy J

2017-07-01

Emotional regulation may be an underaddressed therapeutic target in sex offender treatment. This article presents a case report of "Adam," a Caucasian male referred to a prison-based sex offender treatment program. Adam's social anxiety was recognized as an antecendent to his sexual offending, and treatment of such, as a critical adjunct to sex offender treatment, is discussed herein. Adam's individualized treatment included aspects of rational emotive behavior therapy and time-limited dynamic psychotherapy. Adam showed an increased understanding of his anxiety and improvement in his social interactions, both in the context of treatment groups and with female staff, and was willing to continue follow-up care in the community. This case provides support for the individualized treatment of incarcerated offenders as opposed to exclusively utilizing manualized psychoeducational interventions.

34 CFR 225.3 - What regulations apply to the Credit Enhancement for Charter School Facilities Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Charter School Facilities Program? 225.3 Section 225.3 Education Regulations of the Offices of the... ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM General § 225.3 What regulations apply to the Credit Enhancement for Charter School Facilities Program? The following regulations apply to the Credit Enhancement...

34 CFR 225.3 - What regulations apply to the Credit Enhancement for Charter School Facilities Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Charter School Facilities Program? 225.3 Section 225.3 Education Regulations of the Offices of the... ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM General § 225.3 What regulations apply to the Credit Enhancement for Charter School Facilities Program? The following regulations apply to the Credit Enhancement...

34 CFR 225.3 - What regulations apply to the Credit Enhancement for Charter School Facilities Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Charter School Facilities Program? 225.3 Section 225.3 Education Regulations of the Offices of the... ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM General § 225.3 What regulations apply to the Credit Enhancement for Charter School Facilities Program? The following regulations apply to the Credit Enhancement...

34 CFR 225.3 - What regulations apply to the Credit Enhancement for Charter School Facilities Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Charter School Facilities Program? 225.3 Section 225.3 Education Regulations of the Offices of the... ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM General § 225.3 What regulations apply to the Credit Enhancement for Charter School Facilities Program? The following regulations apply to the Credit Enhancement...

34 CFR 225.3 - What regulations apply to the Credit Enhancement for Charter School Facilities Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Charter School Facilities Program? 225.3 Section 225.3 Education Regulations of the Offices of the... ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM General § 225.3 What regulations apply to the Credit Enhancement for Charter School Facilities Program? The following regulations apply to the Credit Enhancement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of... ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering Improvement Program? The following regulations apply to the Minority Science and Engineering Improvement...

Supplemental Nutrition Assistance Program: Nutrition Education and Obesity Prevention Grant Program. Final rule.

PubMed

2016-03-31

This rule adopts the interim rule implementing the Supplemental Nutrition Assistance Program (SNAP) nutrition education and obesity prevention grant program with changes as provided in this rule. This rule also amends SNAP regulations to implement section 28 of the Food and Nutrition Act (FNA) of 2008, as added by section 241 of the Healthy, Hunger-Free Kids Act (HHFKA) of 2010, to award grants to States for provision of nutrition education and obesity prevention programs. These programs provide services for eligible individuals that promote healthy food choices consistent with the current Dietary Guidelines for Americans (DGAs). The rule provides State agencies with requirements for implementing section 28, including the grant award process and describes the process for allocating the Federal grant funding for each State's approved SNAP-Ed plan authorized under the FNA to carry out nutrition education and obesity prevention services each fiscal year. This final rule also implements section 4028 of the Agricultural Act of 2014 (Farm Bill of 2014), which authorizes physical activity promotion in addition to promotion of healthy food choices as part of this nutrition education and obesity prevention program.

34 CFR 280.3 - What regulations apply to this program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program... Department of Education programs and activities), 80 (Uniform Administrative Requirements for Grants and...

34 CFR 280.3 - What regulations apply to this program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program... Department of Education programs and activities), 80 (Uniform Administrative Requirements for Grants and...

34 CFR 280.3 - What regulations apply to this program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program... Department of Education programs and activities), 80 (Uniform Administrative Requirements for Grants and...

34 CFR 280.3 - What regulations apply to this program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program... Department of Education programs and activities), 80 (Uniform Administrative Requirements for Grants and...

34 CFR 280.3 - What regulations apply to this program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program... Department of Education programs and activities), 80 (Uniform Administrative Requirements for Grants and...

Individualism-Collectivism, Social Self-Control and Adolescent Substance Use and Risky Sexual Behavior.

PubMed

Pokhrel, Pallav; Bennett, Brooke L; Regmi, Sakshi; Idrisov, Bulat; Galimov, Artur; Akhmadeeva, Leila; Sussman, Steve

2018-06-07

Individualism and collectivism are cultural syndromes that have been associated with adolescent problem behavior in studies conducted in the U.S. and Southeast Asia. However, research investigating the mechanisms of how cultural orientation impacts health risk behaviors has been limited. This study tested a new model explaining the relationship between cultural orientation (i.e., individualism, collectivism) and adolescent problem behavior (i.e., substance use and risky sex) in terms of interpersonal self-regulation (i.e., social self-control). As such, the study is rooted in theories of the role of culture in developing self-regulation. Participants were high school students (N = 716) from the Bashkirtostan Republic of the Russian Federation. Adolescents from the Russian Federation tend to show high prevalence of cigarette smoking and binge drinking. People of the Russian Federation in general are traditionally collectivist in orientation, although increased globalization and post-Soviet capitalism may indicate high individualist values in younger generation Russians. Using path analysis we found that in addition to having direct effects, higher individualism indirectly affected substance use and risky sexual behavior through social self-control and negative life events. Higher collectivism was found to have a direct protective effect on risky sexual behavior and a direct effect on social self-control. However, collectivism was not found to have indirect effects on substance use or risky sexual behavior. Higher individualism appears to function as a risk factor for adolescent problem behavior and this relationship may be mediated by lower social self-control. Culturally-tailored prevention programs utilizing the individualism-collectivism framework may benefit from addressing social self-control.

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.

PubMed

Obier, Nadine; Bonifer, Constanze

2016-11-01

Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue-specific transcription factors (TFs) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TFs regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development. © 2016 Federation of European Biochemical Societies.

Exploring efficacy of residential energy efficiency programs in Florida

NASA Astrophysics Data System (ADS)

Taylor, Nicholas Wade

Electric utilities, government agencies, and private interests in the U.S. have committed and continue to invest substantial resources in the pursuit of energy efficiency and conservation through demand-side management (DSM) programs. Program investments, and the demand for impact evaluations that accompany them, are projected to grow in coming years due to increased pressure from state-level energy regulation, costs and challenges of building additional production capacity, fuel costs and potential carbon or renewable energy regulation. This dissertation provides detailed analyses of ex-post energy savings from energy efficiency programs in three key sectors of residential buildings: new, single-family, detached homes; retrofits to existing single-family, detached homes; and retrofits to existing multifamily housing units. Each of the energy efficiency programs analyzed resulted in statistically significant energy savings at the full program group level, yet savings for individual participants and participant subgroups were highly variable. Even though savings estimates were statistically greater than zero, those energy savings did not always meet expectations. Results also show that high variability in energy savings among participant groups or subgroups can negatively impact overall program performance and can undermine marketing efforts for future participation. Design, implementation, and continued support of conservation programs based solely on deemed or projected savings is inherently counter to the pursuit of meaningful energy conservation and reductions in greenhouse gas emissions. To fully understand and optimize program impacts, consistent and robust measurement and verification protocols must be instituted in the design phase and maintained over time. Furthermore, marketing for program participation must target those who have the greatest opportunity for savings. In most utility territories it is not possible to gain access to the type of large scale datasets that would facilitate robust program analysis. Along with measuring and optimizing energy conservation programs, utilities should provide public access to historical consumption data. Open access to data, program optimization, consistent measurement and verification and transparency in reported savings are essential to reducing energy use and its associated environmental impacts.

Impact of visual learning on facial expressions of physical distress: a study on voluntary and evoked expressions of pain in congenitally blind and sighted individuals.

PubMed

Kunz, Miriam; Faltermeier, Nicole; Lautenbacher, Stefan

2012-02-01

The ability to facially communicate physical distress (e.g. pain) can be essential to ensure help, support and clinical treatment for the individual experiencing physical distress. So far, it is not known to which degree this ability represents innate and biologically prepared programs or whether it requires visual learning. Here, we address this question by studying evoked and voluntary facial expressions of pain in congenitally blind (N=21) and sighted (N=42) individuals. The repertoire of evoked facial expressions was comparable in congenitally blind and sighted individuals; however, blind individuals were less capable of facially encoding different intensities of experimental pain. Moreover, blind individuals were less capable of voluntarily modulating their pain expression. We conclude that the repertoire of facial muscles being activated during pain is biologically prepared. However, visual learning is a prerequisite in order to encode different intensities of physical distress as well as for up- and down-regulation of one's facial expression. Copyright © 2011 Elsevier B.V. All rights reserved.

[Age factor in a complex evaluation of health of air staff].

PubMed

Ushakov, I B; Batishcheva, G A; Chernov, Iu N; Khomenko, M N; Soldatov, S K

2010-03-01

Was elaborated program of a complex of estimation of health condition of air staff with determination of capability of early diagnostic of functional tension of physiological systems. According to this system there were observed 73 airmen using a complex of tests (estimation of level of pectoral control, of personal and reactive anxiety, vegetal regulation etc.). Was detected, that length of service and sympato-adrenaline activeness with vicarious decrease of adrenoreactiveness are in direct proportion. Were marked the most informative indexes of estimation of functional tension of psycho-physiological functions, vegetative regulation and cardiovascular system. Was shown that the elaborated system of individual estimation of health of air staff permits diagnose prenosological conditions and determine indexes for rehabilitation treatment.

30 CFR 736.23 - Federal program effect on State law or regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FOR A STATE § 736.23 Federal program effect on State law or regulations. (a) Whenever a Federal program is promulgated or revised for a State, any statutes or regulations of the State regulating coal... in the Federal Register any State statute or regulation which is preempted and superseded by the...

30 CFR 736.23 - Federal program effect on State law or regulations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FOR A STATE § 736.23 Federal program effect on State law or regulations. (a) Whenever a Federal program is promulgated or revised for a State, any statutes or regulations of the State regulating coal... in the Federal Register any State statute or regulation which is preempted and superseded by the...

30 CFR 736.23 - Federal program effect on State law or regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FOR A STATE § 736.23 Federal program effect on State law or regulations. (a) Whenever a Federal program is promulgated or revised for a State, any statutes or regulations of the State regulating coal... in the Federal Register any State statute or regulation which is preempted and superseded by the...

30 CFR 736.23 - Federal program effect on State law or regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOR A STATE § 736.23 Federal program effect on State law or regulations. (a) Whenever a Federal program is promulgated or revised for a State, any statutes or regulations of the State regulating coal... in the Federal Register any State statute or regulation which is preempted and superseded by the...

30 CFR 736.23 - Federal program effect on State law or regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOR A STATE § 736.23 Federal program effect on State law or regulations. (a) Whenever a Federal program is promulgated or revised for a State, any statutes or regulations of the State regulating coal... in the Federal Register any State statute or regulation which is preempted and superseded by the...

The use of geologic and seismologic information to reduce earthquake Hazards in California

USGS Publications Warehouse

Kockelman, W.J.; Campbell, C.C.

1984-01-01

Five examples illustrate how geologic and seismologic information can be used to reduce the effects of earthquakes Included are procedures for anticipating damage to critical facilities, preparing, adopting, or implementing seismic safety studies, plans, and programs, retrofitting highway bridges, regulating development in areas subject to fault-rupture, and strengthening or removing unreinforced masonry buildings. The collective effect of these procedures is to improve the public safety, health, and welfare of individuals and their communities. ?? 1984 Springer-Verlag New York Inc.

Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300.

PubMed

Tikhanovich, Irina; Zhao, Jie; Bridges, Brian; Kumer, Sean; Roberts, Ben; Weinman, Steven A

2017-08-11

Protein arginine methyltransferase 1 (PRMT1) is an essential enzyme controlling about 85% of the total cellular arginine methylation in proteins. We have shown previously that PRMT1 is an important regulator of innate immune responses and that it is required for M2 macrophage differentiation. c-Myc is a transcription factor that is critical in regulating cell proliferation and also regulates the M2 transcriptional program in macrophages. Here, we sought to determine whether c-Myc in myeloid cells is regulated by PRMT1-dependent arginine methylation. We found that PRMT1 activity was necessary for c-Myc binding to the acetyltransferase p300. PRMT1 inhibition decreased p300 recruitment to c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decreasing transcription at these sites. Moreover, PRMT1 inhibition blocked c-Myc-mediated induction of several of its target genes, including peroxisome proliferator-activated receptor γ ( PPARG ) and mannose receptor C-type 1 ( MRC1 ), suggesting that PRMT1 is necessary for c-Myc function in M2 macrophage differentiation. Of note, in primary human blood monocytes, p300-c-Myc binding was strongly correlated with PRMT1 expression, and in liver sections, PRMT1, c-Myc, and M2 macrophage levels were strongly correlated with each other. Both PRMT1 levels and M2 macrophage numbers were significantly lower in livers from individuals with a history of spontaneous bacterial peritonitis, known to have defective cellular immunity. In conclusion, our findings demonstrate that PRMT1 is an important regulator of c-Myc function in myeloid cells. PRMT1 loss in individuals with cirrhosis may contribute to their immune defects. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Inside the Hotline: A compilation of 1991 monthly Hotline reports. Annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-03-01

The Resource Conservation and Recovery Act (RCRA)/Superfund (SF)/Office of Underground Storage Tanks (OUST) and Emergency Planning and Community Right-to-Know (EPCRA) Hotlines were established to respond to inquiries from the regulated community and the public concerning waste management and disposal regulations. The Hotline also serves as a referral point on the availability and distribution of program related documents and published materials. The document is a compilation of questions and answers, Federal Register summaries from individual Monthly Hotline Reports for the period of January to December 1991. It also contains user-friendly indices which are arranged according to subject matter, regulatory and statorymore » citations. The document can be used by its reader to explore the application of the regulations in different scenarios or to shed light on complex issues. Neither the questions nor the FR summaries are intended to fully represent or be used in place of the regulations. For an understanding of the actual regulatory requirements in any given situation, the reader must consult the appropriate sections of Title 40 of the Code of Federal Regulations, pertinent FR and EPA guidance documents, as well as relevant State regulations.« less

48 CFR 601.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 601.403 Section 601.403 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL DEPARTMENT OF STATE ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 601.403 Individual deviations. The...

HIV-1 Tat affects the programming and functionality of human CD8⁺ T cells by modulating the expression of T-box transcription factors.

PubMed

Sforza, Fabio; Nicoli, Francesco; Gallerani, Eleonora; Finessi, Valentina; Reali, Eva; Cafaro, Aurelio; Caputo, Antonella; Ensoli, Barbara; Gavioli, Riccardo

2014-07-31

HIV infection is characterized by several immune dysfunctions of both CD8⁺ and CD4⁺ T cells as hyperactivation, impairment of functionality and expansion of memory T cells. CD8⁺ T-cell dysfunctions have been associated with increased expression of T-bet, Eomesdermin and pro-inflammatory cytokines, and with down-regulation of CD127. The HIV-1 trans-activator of transcription (Tat) protein, which is released by infected cells and detected in tissues of HIV-positive individuals, is known to contribute to the dysregulation of CD4⁺ T cells; however, its effects on CD8⁺ T cells have not been investigated. Thus, in this study, we sought to address whether Tat may affect CD8⁺ T-cell functionality and programming. CD8⁺ T cells were activated by T-cell receptor engagement in the presence or absence of Tat. Cytokine production, killing capacity, surface phenotype and expression of transcription factors important for T-cell programming were evaluated. Tat favors the secretion of interleukin-2, interferon-γ and granzyme B in CD8⁺ T cells. Behind this functional modulation we observed that Tat increases the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6 and Bcl-2 in activated but not in unstimulated CD8⁺ T lymphocytes. This effect is associated with the down-regulation of CD127 and the up-regulation of CD27. Tat deeply alters the programming and functionality of CD8⁺ T lymphocytes.

48 CFR 1401.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations. 1401.403 Section 1401.403 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Deviations from the FAR and DIAR 1401.403 Individual...

Supported exercise improves controlled eating and weight through its effects on psychosocial factors: extending a systematic research program toward treatment development.

PubMed

Annesi, James J

2012-01-01

Behavioral weight-loss treatments have been overwhelmingly unsuccessful. Many inadequately address both behavioral theory and extant research--especially in regard to the lack of viability of simply educating individuals on improved eating and exercise behaviors. The aim was to synthesize research on associations of changes in exercise behaviors, psychosocial factors, eating behaviors, and weight; and then conduct further direct testing to inform the development of an improved treatment approach. A systematic program of health behavior-change research based on social cognitive theory, and extensions of that theory applied to exercise and weight loss, was first reviewed. Then, to extend this research toward treatment development and application, a field-based study of obese adults was conducted. Treatments incorporated a consistent component of cognitive-behaviorally supported exercise during 26 weeks that was paired with either standard nutrition education (n = 183) or cognitive-behavioral methods for controlled eating that emphasized self-regulatory methods such as goal setting and caloric tracking, cognitive restructuring, and eating cue awareness (n = 247). Both treatment conditions were associated with improved self-efficacy, self-regulation, mood, exercise, fruit and vegetable consumption, weight, and waist circumference; with improvements in self-regulation for eating, fruit and vegetable consumption, weight, and waist circumference significantly greater in the cognitive-behavioral nutrition condition. Changes in exercise- and eating-related self-efficacy and self-regulation were associated with changes in exercise and eating (R(2) = 0.40 and 0.17, respectively), with mood change increasing the explanatory power to R(2) = 0.43 and 0.20. Improved self-efficacy and self-regulation for exercise carried over to self-efficacy and self-regulation for controlled eating (β= 0.53 and 0.68, respectively). Development and longitudinal testing of a new and different approach to behavioral treatment for sustained weight loss that emphasizes exercise program-induced psychosocial changes preceding the facilitation of improved eating and weight loss should be guided by our present research.

Challenges to Developmental Regulation across the Life Course: What Are They and Which Individual Differences Matter?

ERIC Educational Resources Information Center

Heckhausen, Jutta; Wrosch, Carsten

2016-01-01

We discuss the major processes involved in individuals' motivation and self-regulation of goal striving throughout the life course. While much is regulated based on the biological and societal scaffolding of lifespan development, certain challenges for motivation and self-regulation are more substantial and need to be managed by the individual,…

48 CFR 22.804 - Affirmative action programs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs. ...

48 CFR 22.804 - Affirmative action programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs. ...

34 CFR 477.4 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF EDUCATION STATE PROGRAM ANALYSIS ASSISTANCE AND POLICY STUDIES PROGRAM General § 477.4 What regulations apply? The following regulations apply to the State Program Analysis Assistance and Policy Studies...

34 CFR 477.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION STATE PROGRAM ANALYSIS ASSISTANCE AND POLICY STUDIES PROGRAM General § 477.4 What regulations apply? The following regulations apply to the State Program Analysis Assistance and Policy Studies...

Behavioral and pharmacologic therapies for obesity

PubMed Central

Vetter, Marion L.; Faulconbridge, Lucy F.; Webb, Victoria L.; Wadden, Thomas A.

2011-01-01

This article reviews novel developments in the behavioral and pharmacologic treatment of obesity and explores the potential contribution of genomics research to weight control. A comprehensive program of lifestyle modification, comprised of diet, physical activity and behavior therapy, induces a mean loss of 7–10% of initial weight in individuals with obesity. Two trials demonstrated that weight loss of this magnitude, combined with increased physical activity, substantially reduced the risk of developing type 2 diabetes mellitus in individuals with impaired glucose tolerance. A third trial is now investigating whether a lifestyle intervention will reduce cardiovascular morbidity and mortality in overweight individuals who already have diabetes mellitus. Pharmacotherapy is recommended, in some patients, as an adjunct to lifestyle modification. Two medications—orlistat and sibutramine—are currently approved in the US for long-term weight loss. Both are efficacious when combined with lifestyle modification, although health concerns have been raised about the use of sibutramine. Several novel combination therapies, which target multiple hypothalamic pathways that regulate appetite and body weight, are currently under investigation. Genomic studies provide further evidence for the role of these pathways in the regulation of body weight. Identification of new genes controlling satiety and energy expenditure may yield valuable clues for the development of novel pharmacologic treatments. PMID:20680034

48 CFR 225.872-4 - Individual determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Individual determinations. 225.872-4 Section 225.872-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... and Coordination 225.872-4 Individual determinations. If the offer of an end product from a qualifying...

Individual Differences in Automatic Emotion Regulation Interact with Primed Emotion Regulation during an Anger Provocation.

PubMed

Zhang, Jing; Lipp, Ottmar V; Hu, Ping

2017-01-01

The current study investigated the interactive effects of individual differences in automatic emotion regulation (AER) and primed emotion regulation strategy on skin conductance level (SCL) and heart rate during provoked anger. The study was a 2 × 2 [AER tendency (expression vs. control) × priming (expression vs. control)] between subject design. Participants were assigned to two groups according to their performance on an emotion regulation-IAT (differentiating automatic emotion control tendency and automatic emotion expression tendency). Then participants of the two groups were randomly assigned to two emotion regulation priming conditions (emotion control priming or emotion expression priming). Anger was provoked by blaming participants for slow performance during a subsequent backward subtraction task. In anger provocation, SCL of individuals with automatic emotion control tendencies in the control priming condition was lower than of those with automatic emotion control tendencies in the expression priming condition. However, SCL of individuals with automatic emotion expression tendencies did no differ in the automatic emotion control priming or the automatic emotion expression priming condition. Heart rate during anger provocation was higher in individuals with automatic emotion expression tendencies than in individuals with automatic emotion control tendencies regardless of priming condition. This pattern indicates an interactive effect of individual differences in AER and emotion regulation priming on SCL, which is an index of emotional arousal. Heart rate was only sensitive to the individual differences in AER, and did not reflect this interaction. This finding has implications for clinical studies of the use of emotion regulation strategy training suggesting that different practices are optimal for individuals who differ in AER tendencies.

77 FR 6673 - Removal of the Indian HOME Investment Partnerships Program Regulation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... Removal of the Indian HOME Investment Partnerships Program Regulation AGENCY: Office of the Assistant... outdated regulations for the Indian HOME Investment Partnerships (Indian HOME) program. Under the Indian... Investment Partnerships Program The HOME Investment Partnerships Act (Title II of the Cranston- Gonzales...

Application of proteomics in the discovery of candidate protein biomarkers in a Diabetes Autoantibody Standardization Program (DASP) sample subset

PubMed Central

Metz, Thomas O.; Qian, Wei-Jun; Jacobs, Jon M.; Gritsenko, Marina A.; Moore, Ronald J.; Polpitiya, Ashoka D.; Monroe, Matthew E.; Camp, David G.; Mueller, Patricia W.; Smith, Richard D.

2009-01-01

Novel biomarkers of type 1 diabetes must be identified and validated in initial, exploratory studies before they can be assessed in proficiency evaluations. Currently, untargeted “-omics” approaches are under-utilized in profiling studies of clinical samples. This report describes the evaluation of capillary liquid chromatography (LC) coupled with mass spectrometry (MS) in a pilot proteomic analysis of human plasma and serum from a subset of control and type 1 diabetic individuals enrolled in the Diabetes Autoantibody Standardization Program with the goal of identifying candidate biomarkers of type 1 diabetes. Initial high-resolution capillary LC-MS/MS experiments were performed to augment an existing plasma peptide database, while subsequent LC-FTICR studies identified quantitative differences in the abundance of plasma proteins. Analysis of LC-FTICR proteomic data identified five candidate protein biomarkers of type 1 diabetes. Alpha-2-glycoprotein 1 (zinc), corticosteroid-binding globulin, and lumican were 2-fold up-regulated in type 1 diabetic samples relative to control samples, whereas clusterin and serotransferrin were 2-fold up-regulated in control samples relative to type 1 diabetic samples. Observed perturbations in the levels of all five proteins are consistent with the metabolic aberrations found in type 1 diabetes. While the discovery of these candidate protein biomarkers of type 1 diabetes is encouraging, follow up studies are required for validation in a larger population of individuals and for determination of laboratory-defined sensitivity and specificity values using blinded samples. PMID:18092746

Application of proteomics in the discovery of candidate protein biomarkers in a diabetes autoantibody standardization program sample subset.

PubMed

Metz, Thomas O; Qian, Wei-Jun; Jacobs, Jon M; Gritsenko, Marina A; Moore, Ronald J; Polpitiya, Ashoka D; Monroe, Matthew E; Camp, David G; Mueller, Patricia W; Smith, Richard D

2008-02-01

Novel biomarkers of type 1 diabetes must be identified and validated in initial, exploratory studies before they can be assessed in proficiency evaluations. Currently, untargeted "-omics" approaches are underutilized in profiling studies of clinical samples. This report describes the evaluation of capillary liquid chromatography (LC) coupled with mass spectrometry (MS) in a pilot proteomic analysis of human plasma and serum from a subset of control and type 1 diabetic individuals enrolled in the Diabetes Autoantibody Standardization Program, with the goal of identifying candidate biomarkers of type 1 diabetes. Initial high-resolution capillary LC-MS/MS experiments were performed to augment an existing plasma peptide database, while subsequent LC-FTICR studies identified quantitative differences in the abundance of plasma proteins. Analysis of LC-FTICR proteomic data identified five candidate protein biomarkers of type 1 diabetes. alpha-2-Glycoprotein 1 (zinc), corticosteroid-binding globulin, and lumican were 2-fold up-regulated in type 1 diabetic samples relative to control samples, whereas clusterin and serotransferrin were 2-fold up-regulated in control samples relative to type 1 diabetic samples. Observed perturbations in the levels of all five proteins are consistent with the metabolic aberrations found in type 1 diabetes. While the discovery of these candidate protein biomarkers of type 1 diabetes is encouraging, follow up studies are required for validation in a larger population of individuals and for determination of laboratory-defined sensitivity and specificity values using blinded samples.

48 CFR 53.301-28 - Affidavit of Individual Surety.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Affidavit of Individual Surety. 53.301-28 Section 53.301-28 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-28 Affidavit of Individual Surety. ER22MY03...

A self-lysis pathway that enhances the virulence of a pathogenic bacterium.

PubMed

McFarland, Kirsty A; Dolben, Emily L; LeRoux, Michele; Kambara, Tracy K; Ramsey, Kathryn M; Kirkpatrick, Robin L; Mougous, Joseph D; Hogan, Deborah A; Dove, Simon L

2015-07-07

In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we describe a potential PCD pathway in Pseudomonas aeruginosa that enhances the ability of the bacterium to cause disease in a lung infection model. Activation of the system can occur in a subset of cells in response to DNA damage through cleavage of an essential transcription regulator we call AlpR. Cleavage of AlpR triggers a cell lysis program through de-repression of the alpA gene, which encodes a positive regulator that activates expression of the alpBCDE lysis cassette. Although this is lethal to the individual cell in which it occurs, we find it benefits the population as a whole during infection of a mammalian host. Thus, host and pathogen each may use PCD as a survival-promoting strategy. We suggest that activation of the Alp cell lysis pathway is a disease-enhancing response to bacterial DNA damage inflicted by the host immune system.

The ESRD Quality Incentive Program—Can We Bridge the Chasm?

PubMed Central

Weiner, Daniel

2017-01-01

The ESRD Quality Incentive Program (QIP) is the first mandatory federal pay for performance program launched on January 1, 2012. The QIP is tied to the ESRD prospective payment system and mandated by the Medicare Improvements for Patients and Providers Act of 2008, which directed the Centers for Medicare and Medicaid Services to expand the payment bundle for renal dialysis services and legislated that payment be tied to quality measures. The QIP links 2% of the payment that a dialysis facility receives for Medicare patients on dialysis to the facility’s performance on quality of care measures. Quality measures are evaluated annually for inclusion on the basis of importance, validity, and performance gap. Other quality assessment programs overlap with the QIP; all have substantial effects on provision of care as clinicians, patients, regulators, and dialysis organizations scramble to keep up with the frequent release of wide-ranging regulations. In this review, we provide an overview of quality assessment and quality measures, focusing on the ESRD QIP, its effect on care, and its potential future directions. We conclude that a patient-centered, individualized, and parsimonious approach to quality assessment needs to be maintained to allow the nephrology community to further bridge the quality chasm in dialysis care. PMID:28298324

A systematic review and meta-analysis of lower limb neuromuscular alterations associated with knee osteoarthritis during level walking.

PubMed

Mills, Kathryn; Hunt, Michael A; Leigh, Ryan; Ferber, Reed

2013-08-01

Neuromuscular alterations are increasingly reported in individuals with knee osteoarthritis (KOA) during level walking. We aimed to determine which neuromuscular alterations are consistent in KOA individuals and how these may be influenced by osteoarthritis severity, varus alignment and/or joint laxity. Electronic databases were searched up to July 2012. Cross-sectional observational studies comparing lower-limb neuromuscular activity in individuals with KOA, healthy controls or with different KOA cohorts were included. Two reviewers assessed methodological quality. Effect sizes were used to quantify the magnitude of observed differences. Where studies were homogenous, effect sizes were pooled using a fixed-effects model. Fourteen studies examining neuromuscular alterations in indices of co-contraction, muscle amplitude and muscle activity duration were included. Data pooling revealed that moderate KOA individuals exhibit increased co-contraction of lateral knee muscles (ES 0.64 [0.3 to 0.97]) and moderately increased rectus femoris (ES 0.73 [0.23 to 1.22]), vastus lateralis (ES 0.77 [0.27 to 1.27]) and biceps femoris (ES 1.18 [0.67 to 1.7]) mean amplitude. Non-pooled data indicated prolonged activity of these muscles. Increased medial knee neuromuscular activity was prevalent for those exhibiting varus alignment and medial knee joint laxity. Interpretation Individuals with KOA exhibited increased co-contraction, amplitude and duration of lateral knee muscles regardless of disease severity, limb alignment or medial joint laxity. Individuals with severe disease, varus alignment and medial joint laxity demonstrate up-regulation of medial knee muscles. Future research investigating the efficacy of neuromuscular rehabilitation programs should consider the effect of simultaneous up-regulation of medial and lateral knee muscles on disease progression. © 2013.

Directed evolution of a synthetic phylogeny of programmable Trp repressors.

PubMed

Ellefson, Jared W; Ledbetter, Michael P; Ellington, Andrew D

2018-04-01

As synthetic regulatory programs expand in sophistication, an ever increasing number of biological components with predictable phenotypes is required. Regulators are often 'part mined' from a diverse, but uncharacterized, array of genomic sequences, often leading to idiosyncratic behavior. Here, we generate an entire synthetic phylogeny from the canonical allosteric transcription factor TrpR. Iterative rounds of positive and negative compartmentalized partnered replication (CPR) led to the exponential amplification of variants that responded with high affinity and specificity to halogenated tryptophan analogs and novel operator sites. Fourteen repressor variants were evolved with unique regulatory profiles across five operators and three ligands. The logic of individual repressors can be modularly programmed by creating heterodimeric fusions, resulting in single proteins that display logic functions, such as 'NAND'. Despite the evolutionarily limited regulatory role of TrpR, vast functional spaces exist around this highly conserved protein scaffold and can be harnessed to create synthetic regulatory programs.

A preliminary investigation of a school-based musical theater intervention program for children with intellectual disabilities.

PubMed

Zyga, Olena; Russ, Sandra W; Meeker, Heather; Kirk, Jodi

2017-01-01

The presence of an intellectual disability may cause a child to have significant deficits in social skills and emotion regulation abilities across development. A vital next step is to find interventions that can be delivered in the school environment and across disability categories that target socioemotional factors. The current study investigated the feasibility of delivering a school-based musical theater program to students with intellectual disability across a range of school settings. A within-group repeated-measures design was used to analyze pre- and post-video recordings of the intervention program, which were coded for six domains of socioemotional ability across all participants ( n = 47). Results showed that significant gains across all domains were observed. However, these gains related to school- and individual-level student factors, such as grade level, severity of disability, and baseline social skill ability.

Predictors of Premature Match Closure in Youth Mentoring Relationships.

PubMed

Kupersmidt, Janis B; Stump, Kathryn N; Stelter, Rebecca L; Rhodes, Jean E

2017-03-01

Although mentoring is a popular and effective means of intervention with youth, the positive effects of mentoring can be diminished by premature match closure of relationships. Program, mentor, and mentee characteristics were examined as predictors of premature match closure. Secondary data analyses were conducted on a large national database of mentoring programs consisting of match and youth risk information from 170 mentoring programs and 6468 matches from across the U.S. Premature closure was associated with mentee age at match inception and 19 individual mentee characteristics. The set of mentee characteristics were examined as part of a cumulative risk index encompassing seven conceptually combined categories including family background characteristics, school functioning problems, engagement in risky health behaviors, self-regulation difficulties, engagement in illegal or criminal activities, and internalizing and externalizing behavior problems. Both the age of mentees when matched and the cumulative risk index score significantly predicted premature closure. Results are discussed in terms of directions for future research and suggestions for enhancing mentoring program practices. © Society for Community Research and Action 2017.

48 CFR 19.1007 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedures. 19.1007 Section 19.1007 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1007 Procedures...

48 CFR 19.1004 - Participating agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Participating agencies. 19.1004 Section 19.1004 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1004...

48 CFR 19.1006 - Exclusions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Exclusions. 19.1006 Section 19.1006 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1006 Exclusions...

48 CFR 19.1003 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Purpose. 19.1003 Section 19.1003 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1003 Purpose. The...

48 CFR 19.1002 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Definitions. 19.1002 Section 19.1002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1002 Definitions...

[The legal regulation of mother and child health care in the Federal Law "On the fundamentals of health care of citizen in the Russian Federation"].

PubMed

Rastegaeva, I N

2012-01-01

The article presents the analysis of legal foundations of mother and child health care in the Federal Law No 323-FZ November 21 2011 "On the fundamentals of health care of citizen in the Russian Federation". The regulation applied in the Law concerning the public relations in the area of maternity and children care is supported by the public protection of mother and child interests and enhancement of their individual rights. This measure is provided by the development and implementation of programs targeted to prevention early detection and treatment of diseases, decrease of maternity and infant mortality, and development in children and their parents the motivation to healthy life-style and applying mechanisms of prevention and dispensarization.

Complement-Related Regulates Autophagy in Neighboring Cells.

PubMed

Lin, Lin; Rodrigues, Frederico S L M; Kary, Christina; Contet, Alicia; Logan, Mary; Baxter, Richard H G; Wood, Will; Baehrecke, Eric H

2017-06-29

Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program. Copyright © 2017 Elsevier Inc. All rights reserved.

34 CFR 642.4 - Regulations that apply to the Training Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Regulations that apply to the Training Program. 642.4 Section 642.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION TRAINING PROGRAM FOR FEDERAL TRIO PROGRAMS General § 642.4...

A pilot study examining the effect of mindfulness-based stress reduction on symptoms of chronic mild traumatic brain injury/postconcussive syndrome.

PubMed

Azulay, Joanne; Smart, Colette M; Mott, Tasha; Cicerone, Keith D

2013-01-01

To evaluate the effectiveness of the mindfulness-based stress reduction (MBSR) program tailored to individuals with mild traumatic brain injury (mTBI). A convenience sample recruited from clinical referrals over a 2-year period completed outcome measures pre- and posttreatment intervention. Post-acute brain injury rehabilitation center within a suburban medical facility. Twenty-two individuals with mTBI and a time postinjury more than 7 months. Eleven participants were men and 11 were women, ranging in age from 18 to 62 years. A 10-week group (with weekly 2-hour sessions) modeled after the MBSR program of Kabat-Zinn, but with modifications designed to facilitate implementation in a population of individuals with brain injury. (The treatment involved enhancement of attentional skills, in addition to increased awareness of internal and external experiences associated with the perspective change of acceptance and nonjudgmental attitude regarding those experiences). Perceived Quality of Life Scale, Perceived Self-Efficacy Scale, and the Neurobehavioral Symptom Inventory. Secondary measures included neuropsychological tests, a self-report problem-solving inventory, and a self-report measure of mindfulness. Clinically meaningful improvements were noted on measures of quality of life (Cohen d = 0.43) and perceived self-efficacy (Cohen d = 0.50) with smaller but still significant effects on measures of central executive aspects of working memory and regulation of attention. The MBSR program can be adapted for participants with mTBI. Improved performance on measures associated with improved quality of life and self-efficacy may be related to treatment directed at improving awareness and acceptance, thereby minimizing the catastrophic assessment of symptoms associated with mTBI and chronic disability. Additional research on the comparative effectiveness of the MBSR program for people with mTBI is warranted.

20 CFR 668.870 - What is “program income” and how is it regulated in the INA program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What is âprogram incomeâ and how is it regulated in the INA program? 668.870 Section 668.870 Employees' Benefits EMPLOYMENT AND TRAINING... ACT Administrative Requirements § 668.870 What is “program income” and how is it regulated in the INA...

Enrollment of Specialty Mental Health Clinics in a State Medicaid Program to Promote Physical Health Services

PubMed Central

Breslau, Joshua; Yu, Hao; Horvitz-Lennon, Marcela; Leckman-Westin, Emily; Scharf, Deborah M.; Connor, Kathryn; Finnerty, Molly T.

2016-01-01

OBJECTIVE To promote integrated physical health care for individuals with serious mental illness, the New York State Office of Mental Health (NYOMH) established regulations allowing specialty mental health clinics to provide Medicaid-reimbursable health monitoring (HM) and health physicals (HP). This paper examines clinics’ enrollment in this program to understand its potential to reach individuals with serious mental illness. METHODS Information on enrollment and clinic characteristics (N=500) were drawn from NYOMH administrative databases. Clinic enrollment in the HM/HP program was examined from the program’s first five years (2010–2015). Logistic regression models accounting for the clustering of multiple clinics within agencies were used to examine characteristics associated with enrollment. RESULTS Two-hundred ninety one of 500 clinics (58%) enrolled in the HM/HP program, potentially reaching 62.5% of all Medicaid enrollees with serious mental illness seen in specialty mental health clinics in the state. State-operated clinics were required to participate, and had 91.8% enrollment. Over half of hospital-affiliated and freestanding mental health clinics elected to enroll in the program (52.6% and 53.7% respectively). In adjusted models, enrollment was higher among freestanding clinics relative to hospital-affiliated clinics, higher in larger relative to smaller clinics, and higher in county-operated relative to private non-profit clinics. CONCLUSIONS The high level of enrollment in the HM/HP program indicates strong interest among mental health clinics in providing physical health care services. However, supplemental policies may be needed to extend the program to areas of the mental health system where barriers to physical health care services are highest. PMID:27524372

34 CFR 472.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION NATIONAL WORKPLACE LITERACY PROGRAM General § 472.4 What regulations apply? The following regulations apply to the National Workplace Literacy Program: (a) The regulations in this part 472...

75 FR 49595 - Performance of Functions; Claims for Compensation Under the Federal Employees' Compensation Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

...The Department of Labor proposes to amend the regulations governing the administration of the Federal Employees' Compensation Act (FECA), which provides benefits to all civilian Federal employees and certain other groups of employees and individuals who are injured or killed while performing their jobs. The Department of Labor also proposes to revise the regulations establishing the authority of the Office of Workers' Compensation Programs (OWCP) which administers the FECA. The existing rules have been amended to acknowledge a change in the organization of the OWCP and amendments to the FECA which have occurred since the last time the regulations were amended in 1999. These changes also update the regulations by taking into account changes in technology and other changes to improve administrative efficiency. As many FECA claimants are not represented, the regulations are revised to insert FECA statutory references as a frame of reference for clarity and ease of use. The regulations include adding the skin as an organ pursuant to 5 U.S.C. 8107(c)(22). The regulations also create a new special schedule covering injuries to non-citizen non-resident Federal employees outside the United States. Finally, the regulations covering the processing of medical bills have been updated to provide for greater use of technology in that process to reduce costs and to clarify requirements for such submissions.

42 CFR 65a.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false To what programs do these regulations apply? 65a.1..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH AND TRAINING GRANTS § 65a.1 To what programs do these regulations apply? (a) The regulations of this...

42 CFR 65a.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false To what programs do these regulations apply? 65a.1..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH AND TRAINING GRANTS § 65a.1 To what programs do these regulations apply? (a) The regulations of this...

42 CFR 65a.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false To what programs do these regulations apply? 65a.1..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH AND TRAINING GRANTS § 65a.1 To what programs do these regulations apply? (a) The regulations of this...

34 CFR 464.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.4 What regulations apply? The following regulations apply to the State Literacy Resource Centers Program: (a) The regulations in this part...

48 CFR 1501.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 1501.403 Section 1501.403 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.403 Individual deviations. Requests for individual deviations from the FAR and the...

Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death.

PubMed

Craig, Jesse; Orisaka, Makoto; Wang, Hongmei; Orisaka, Sanae; Thompson, Winston; Zhu, Cheng; Kotsuji, Fumikazu; Tsang, Benjamin K

2007-05-01

Regulation of mammalian follicular development is tightly regulated by both cell death and survival signals, including endocrine (e.g. gonadotropin) and intra-ovarian regulators (e.g. Nodal and GDF9). The destiny of the individual follicle (growth/ovulation or atresia) is dependent on a delicate balance in the expression and action of factors promoting follicular cell proliferation, growth and differentiation, and of those promoting programmed cell death (apoptosis). Development of the follicle from the primordial to preantral stage is regulated by oocyte-derived factors including GDF9 and BMP15, and is not dependent on gonadotropin support (gonadotropin-independent stage). As the follicle transits into the early antral stage it becomes responsive to gonadotropin (gonadotropin-responsive stages) and further development renders the follicle completely dependent on the presence of gonadotropin while modulated by intra-ovarian regulators (gonadotropin-dependent). Follicle fate is also regulated by pro-apoptotic factors such as the intraovarian regulator Nodal, which is secreted by the theca and promotes apoptosis of differentiated granulosa cells through a mechanism involving Smad2 signaling and suppression of the PI3K/Akt pathway. The intracellular protein prohibitin (PHB) appears to have a dual role during folliculogenesis; acting as a cell survival factor in undifferentiated cells, and as a pro-apoptotic factor following differentiation. Further investigations of the interplay between these endocrine and ovarian regulators will lead to a better understanding into the regulation of follicular development and atresia, allowing development of new techniques for assisted reproduction.

Qualitative evaluation of Rhode Island’s healthcare worker influenza vaccination regulations

PubMed Central

Lindley, Megan C.; Dube, Donna; Kalayil, Elizabeth J.; Kim, Hanna; Paiva, Kristi; Raymond, Patricia

2015-01-01

Objective To evaluate Rhode Island’s revised vaccination regulations requiring healthcare workers (HCWs) to receive annual influenza vaccination or wear a mask during patient care when influenza is widespread. Design Semi-structured telephone interviews conducted in a random sample of healthcare facilities. Setting Rhode Island healthcare facilities covered by the HCW regulations, including hospitals, nursing homes, community health centers, nursing service agencies, and home nursing care providers. Participants Staff responsible for collecting and/or reporting facility-level HCW influenza vaccination data to comply with Rhode Island HCW regulations. Methods Interviews were transcribed and individually coded by interviewers to identify themes; consensus on coding differences was reached through discussion. Common themes and illustrative quotes are presented. Results Many facilities perceived the revised regulations as extending their existing influenza vaccination policies and practices. Despite variations in implementation, nearly all facilities implemented policies that complied with the minimum requirements of the regulations. The primary barrier to implementing the HCW regulations was enforcement of masking among unvaccinated HCWs, which required timely tracking of vaccination status and additional time and effort by supervisors. Factors facilitating implementation included early and regular communication from the state health department and facilities’ ability to adapt existing influenza vaccination programs to incorporate provisions of the revised regulations. Conclusions Overall, facilities successfully implemented the revised HCW regulations during the 2012–2013 influenza season. Continued maintenance of the regulations is likely to reduce transmission of influenza and resulting morbidity and mortality in Rhode Island’s healthcare facilities. PMID:25192807

48 CFR 19.801 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 19.801 Section 19.801 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.801...

78 FR 8222 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Employers' Qualified Educational Assistance Programs. DATES: Written comments should be received on or... INFORMATION: Title: Employers' Qualified Educational Assistance Programs. OMB Number: 1545-0768. Regulation... furnished to the employee pursuant to a qualified educational assistance program. This regulation requires...

Epigenetic regulation of the glucocorticoid receptor promoter 1(7) in adult rats.

PubMed

Witzmann, Simone R; Turner, Jonathan D; Mériaux, Sophie B; Meijer, Onno C; Muller, Claude P

2012-11-01

Regulation of glucocorticoid receptor (GR) levels is an important stress adaptation mechanism. Transcription factor Nfgi-a and environmentally induced Gr promoter 1 7 methylation have been implicated in fine-tuning the expression of Gr 1 7 transcripts. Here, we investigated Gr promoter 1 7 methylation and Gr 1 7 expression in adult rats exposed to either acute or chronic stress paradigms. A strong negative correlation was observed between the sum of promoter-wide methylation levels and Gr 1 7 transcript levels, independent of the stressor. Methylation of individual sites did not, however, correlate with transcript levels. This suggested that promoter 1 7 was directly regulated by promoter-wide DNA methylation. Although acute stress increased Ngfi-a expression in the hypothalamic paraventricular nucleus (PVN), Gr 1 7 transcript levels remained unaffected despite low methylation levels. Acute stress had little effect on these low methylation levels, except at four hippocampal CpGs. Chronic stress altered the corticosterone response to an acute stressor. In the adrenal and pituitary glands, but not in the brain, this was accompanied by an increase in methylation levels in orchestrated clusters rather than individual CpGs. PVN methylation levels, unaffected by acute or chronic stress, were significantly more variable within- than between-groups, suggesting that they were instated probably during the perinatal period and represent a pre-established trait. Thus, in addition to the known perinatal programming, the Gr 1 7 promoter is epigenetically regulated by chronic stress in adulthood, and retains promoter-wide tissue-specific plasticity. Differences in methylation susceptibility between the PVN in the perinatal period and the peripheral HPA axis tissues in adulthood may represent an important "trait" vs. "state" regulation of the Gr gene.

48 CFR 3019.705 - Responsibilities for the contracting officer under the subcontracting program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 3019.705...

"Structure-size me:" weight and health changes in a four week residential program.

PubMed

Shapiro, Jennifer R; Stout, Anna L; Musante, Gerard J

2006-08-01

The prevalence of obesity has been drastically increasing over the past 20 years. Other obesity related conditions, including type 2 diabetes mellitus, have also increased in a corresponding manner and, in 2005, the American Diabetes Association (ADA) reduced the cut-off for defining impaired blood glucose. Evidence suggests that just a modest amount of weight loss can improve obesity related co-morbidities. The present study first, investigated changes in health measures after participation in a four week residential weight loss program. Second, individuals were classified according to the 2005 criteria for the diagnosis of type 2 diabetes to determine if glucose regulation changed after weight loss. A total of 93 individuals were categorized as normal glucose (n=56), impaired fasting glucose (n=23) or diabetic range (n=14) after initial blood laboratory screening. After four weeks and a 6.5% weight reduction, participants showed significant improvements in health risks. Further, most participants with elevated fasting glucose shifted into a healthier range. Findings are discussed in terms of health improvements that occur after weight loss within a four week lifestyle intervention.

Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction?

PubMed Central

Als, H; Duffy, FH; McAnulty, GB; Fischer, CB; Kosta, S; Butler, SC; Parad, RB; Blickman, JG; Zurakowski, D; Ringer, SA

2014-01-01

Objective This study investigates the effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) on neurobehavioral and electrophysiological functioning of preterm infants with severe intrauterine growth restriction (IUGR). Study Design Thirty IUGR infants, 28 to 33 weeks gestational age, randomized to standard care (control/C = 18), or NIDCAP (experimental/E = 12), were assessed at 2 weeks corrected age (2wCA) and 9 months corrected age (9mCA) in regard to health, anthropometrics, and neurobehavior, and additionally at 2wCA in regard to electrophysiology (EEG). Result The two groups were comparable in health and anthropometrics at 2wCA and 9mCA. The E-group at 2wCA showed significantly better autonomic, motor, and self-regulation functioning, improved motility, intensity and response thresholds, and reduced EEG connectivity among several adjacent brain regions. At 9mCA, the E-group showed significantly better mental performance. Conclusion This is the first study to show NIDCAP effectiveness for IUGR preterm infants. PMID:20651694

A Regional Multi-permit Market for Ecosystem Services

NASA Astrophysics Data System (ADS)

Bernknopf, R.; Amos, P.; Zhang, E.

2014-12-01

Regional cap and trade programs have been in operation since the 1970's to reduce environmental externalities (NOx and SOx emissions) and have been shown to be beneficial. Air quality and water quality limits are enforced through numerous Federal and State laws and regulations while local communities are seeking ways to protect regional green infrastructure and their ecosystems services. Why not combine them in a market approach to reduce many environmental externalities simultaneously? In a multi-permit market program reforestation (land offsets) as part of a nutrient or carbon sequestration trading program would provide a means to reduce agrochemical discharges into streams, rivers, and groundwater. Land conversions also improve the quality and quantity of other environmental externalities such as air pollution. Collocated nonmarket ecosystem services have societal benefits that can expand the crediting system into a multi-permit trading program. At a regional scale it is possible to combine regulation of water quality, air emissions and quality, and habitat conservation and restoration into one program. This research is about the economic feasibility of a Philadelphia regional multi-permit (cap and trade) program for ecosystem services. Instead of establishing individual markets for ecosystem services, the assumption of the spatial portfolio approach is that it is based on the interdependence of ecosystem functions so that market credits encompasses a range of ecosystem services. Using an existing example the components of the approach are described in terms of scenarios of land portfolios and the calculation of expected return on investment and risk. An experiment in the Schuylkill Watershed will be described for ecosystem services such as nutrients in water and populations of bird species along with Green House Gases. The Philadelphia regional market includes the urban - nonurban economic and environmental interactions and impacts.

Emotion Regulation in Current and Remitted Depression: A Systematic Review and Meta-Analysis

PubMed Central

Visted, Endre; Vøllestad, Jon; Nielsen, Morten Birkeland; Schanche, Elisabeth

2018-01-01

Background: Major Depressive Disorder (MDD) is a highly prevalent, recurrent, and potentially chronic disorder. Identifying risk factors and underlying mechanisms to inform preventive and therapeutic interventions is therefore imperative. Emotion regulation is a proposed factor in the development and maintenance of MDD. The aim of the present review was to summarize and synthesize research on self-reported emotion regulation strategy use and emotion regulation abilities in adults diagnosed with current and remitted MDD. Methods: Seventy-two eligible studies were retrieved from databases through a systematic literature search. Group differences between individuals with current MDD, remitted MDD, and healthy controls were calculated using meta-analytic procedures. Meta-regression analyses investigated potential moderator effects on emotion regulation difficulties. Results: Results indicated that individuals with current MDD report higher maladaptive emotion regulation strategy use for avoidance (Hedges' g = 1.3), rumination (g = 2.1), and suppression (g = 1.1) compared to healthy controls. Also, they reported lower adaptive emotion regulation strategy use for acceptance (g = −1.0), problem solving (g = −1.0), and reappraisal (g = −0.7). Individuals with current MDD reported limited general emotion regulation abilities, indicated by higher alexithymia (g = 1.45), lower emotional awareness (g = −0.95), emotional clarity (g = −1.50) and emotional tolerance (g = −1.89). Similar results were found in individuals with remitted MDD for avoidance (g = 1.0), rumination (g = 1.1), suppression (g = 0.6), and general emotion regulation abilities. However, no difference was found between individuals with remitted MDD and healthy controls for adaptive emotion regulation strategies. Meta-regression analyses suggest that age of illness onset, comorbid anxiety and duration of remission influence emotion regulation. Conclusion: The present review and meta-analysis indicates that individuals with current and remitted MDD have difficulties with emotion regulation compared to individuals who have never been depressed. Although depressive symptoms improve, emotion regulation difficulties may continue, and could be a contributing factor to relapse. Our findings inform future research on emotion regulation and psychotherapeutic interventions. PMID:29867700

The future of aeronautical transportation; Proceedings of the Princeton University Conference, Princeton, N.J., November 10, 11, 1975

NASA Technical Reports Server (NTRS)

1976-01-01

Papers are presented on first and second generation supersonic transports, the Supersonic Cruise Aircraft Research Program, wide-body subsonic transports and vertical and short takeoff and landing transports. Aspects of aircraft design are examined including the airframe, propulsion and electronics. Government regulation, cost/benefit analysis of research and development, airline economics and aircraft financing are also considered. The environmental impact of air transportation is discussed with emphasis on atmospheric emissions (including stratospheric pollution) and noise pollution. Individual items are announced in this issue.

Examining the Costs of Federal Overreach into School Meals. Hearing before the Subcommittee on Early Childhood, Elementary and Secondary Education, Committee on Education and the Workforce, U.S. House of Representatives, One Hundred Twelfth Congress, First Session (May 13, 2011). Serial Number 112-23

ERIC Educational Resources Information Center

US House of Representatives, 2011

2011-01-01

This paper presents the Committee on Education and the Workforce's hearing on the costs associated with the recent reauthorization of federal child nutrition programs. Individuals typically think of costs in terms of dollars and cents; however, as is often the case with federal laws and regulations, there is an additional cost that can't be…

24 CFR 5.105 - Other Federal requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the respective program regulations: (a) Nondiscrimination and equal opportunity. The Fair Housing Act... Opportunity in Housing Programs) and implementing regulations at 24 CFR part 107; title VI of the Civil Rights...) (Equal Employment Opportunity Programs) and implementing regulations at 41 CFR chapter 60; Executive...

7 CFR 3015.204 - Federal Register publications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Federal Register publications. 3015.204 Section 3015.204 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL... Register publications. (a) Program regulations. Most grant programs have program-specific regulations...

7 CFR 3015.204 - Federal Register publications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Federal Register publications. 3015.204 Section 3015.204 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL... Register publications. (a) Program regulations. Most grant programs have program-specific regulations...

48 CFR 2401.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2401... DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Deviations 2401.403 Individual deviations. In individual cases, proposed deviations from the FAR or HUDAR shall be submitted to the Senior Procurement...

Regulating chemical hazards in Japan, West Germany, France, the United Kingdom, and the European community: a comparative examination. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coppock, R.

This report is an outgrowth of a National Research Council program initiative to gain a cross-national perspective on the role scientific information has played in hazardous chemical regulation. Although this study is not meant to be evaluative, it is designed to help assess by comparison the decision-making and regulatory mechanisms in U.S. hazard assessment. The chapters on the individual countries are divided into three components: (1) relevant political and administrative traditions that influence expectations about and mechanisms of hazard regulation; (2) a compilation of the relevant statuatory instruments; and (3) the scope of the regulatory jurisdiction. The last category dividesmore » the laws into those which govern industrial plants, emmissions and discharges, worker protection, industrial substances, poisons, agricultural chemicals, food additives, and contaminants, consumer products, transport, chemical waste, and victim compensation. The study concludes with a discussion of ways in which such multinational perspectives might be used to strengthen the regulatory process of the U.S.« less

Compliance with vessel speed restrictions to protect North Atlantic right whales.

PubMed

Silber, Gregory K; Adams, Jeffrey D; Fonnesbeck, Christopher J

2014-01-01

Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies), some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies) received citations and fines. Despite the efforts to inform mariners, initial compliance was low (<5% of the trips were completely <10 knots) but improved in the latter part of the study. Each notification/enforcement program improved compliance to some degree and some may have influenced compliance across the entire regulated community. Citations/fines appeared to have the greatest influence on improving compliance in notified vessels/companies, followed in order of effectiveness by enforcement-office information letters, monthly summaries of vessel operations, and direct at-sea radio contact. Trips by cargo vessels exhibited the greatest change in behavior followed by tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought.

Compliance with vessel speed restrictions to protect North Atlantic right whales

PubMed Central

Adams, Jeffrey D.; Fonnesbeck, Christopher J.

2014-01-01

Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies), some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies) received citations and fines. Despite the efforts to inform mariners, initial compliance was low (<5% of the trips were completely <10 knots) but improved in the latter part of the study. Each notification/enforcement program improved compliance to some degree and some may have influenced compliance across the entire regulated community. Citations/fines appeared to have the greatest influence on improving compliance in notified vessels/companies, followed in order of effectiveness by enforcement-office information letters, monthly summaries of vessel operations, and direct at-sea radio contact. Trips by cargo vessels exhibited the greatest change in behavior followed by tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought. PMID:24949229

Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles.

PubMed

Waterland, Robert A; Kellermayer, Richard; Laritsky, Eleonora; Rayco-Solon, Pura; Harris, R Alan; Travisano, Michael; Zhang, Wenjuan; Torskaya, Maria S; Zhang, Jiexin; Shen, Lanlan; Manary, Mark J; Prentice, Andrew M

2010-12-23

Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype is established stochastically in the early embryo then maintained in differentiated lineages, resulting in dramatic and systemic interindividual variation in epigenetic regulation. In the mouse, maternal nutrition affects this process, with permanent phenotypic consequences for the offspring. MEs have not previously been identified in humans. Here, using an innovative 2-tissue parallel epigenomic screen, we identified putative MEs in the human genome. In autopsy samples, we showed that DNA methylation at these loci is highly correlated across tissues representing all 3 embryonic germ layer lineages. Monozygotic twin pairs exhibited substantial discordance in DNA methylation at these loci, suggesting that their epigenetic state is established stochastically. We then tested for persistent epigenetic effects of periconceptional nutrition in rural Gambians, who experience dramatic seasonal fluctuations in nutritional status. DNA methylation at MEs was elevated in individuals conceived during the nutritionally challenged rainy season, providing the first evidence of a permanent, systemic effect of periconceptional environment on human epigenotype. At MEs, epigenetic regulation in internal organs and tissues varies among individuals and can be deduced from peripheral blood DNA. MEs should therefore facilitate an improved understanding of the role of interindividual epigenetic variation in human disease.

78 FR 17781 - Transportation Worker Identification Credential (TWIC)-Reader Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-22

...In this Notice of Proposed Rulemaking (NPRM), the Coast Guard proposes to require owners and operators of certain vessels and facilities regulated by the Coast Guard to use electronic readers designed to work with the Transportation Worker Identification Credential (TWIC) as an access control measure. This NPRM also proposes additional requirements associated with electronic TWIC readers, including recordkeeping requirements for those owners and operators required to use an electronic TWIC reader, and security plan amendments to incorporate TWIC requirements. The TWIC program, including the proposed TWIC reader requirements in this rule, is an important component of the Coast Guard's multi-layered system of access control requirements and other measures designed to enhance maritime security. This rulemaking action, once final, would build upon existing Coast Guard regulations designed to ensure that only individuals who hold a TWIC are granted unescorted access to secure areas at those locations. The Coast Guard has already promulgated regulations pursuant to the Maritime Transportation Security Act of 2002 (MTSA) that require mariners and other individuals to obtain a TWIC and present it for inspection by security personnel prior to gaining access to such secure areas. By requiring certain vessels and facilities to perform TWIC inspections using electronic TWIC readers, this rulemaking would further enhance security at those locations. This rulemaking would also implement the Security and Accountability For Every Port Act of 2006 electronic TWIC reader requirements.

Programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with gastric cancer.

PubMed

Savabkar, Sanaz; Azimzadeh, Pedram; Chaleshi, Vahid; Nazemalhosseini Mojarad, Ehsan; Aghdaei, Hamid Asadzadeh

2013-01-01

This study aimed to determine the association between PD-1.5C/T (rs2227981, +7785) and the risk of gastric cancer (GC) in an Iranian population. Gastric cancer is the fourth most common cancer in the world. The programmed death 1 (PD-1) is a member of the CD28 super family. PD-1 is a negative regulator of T-cell effector mechanisms which decrease immune responses against cancer. we conducted case- control study to investigate the association of PD-1.5 C/T polymorphism in 122 GC patients and 166 control individuals. DNA was extracted from blood specimens. Genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The frequency of CC, CT and TT genotypes was 53.6%, 42.2% and 4.2% in control group and 41%, 54.1% and 4.9% in gastric cancer patients respectively. CC genotype was more frequent in control individuals than in patients but we found no statically significant association. The frequencies of PD-1.5CT genotypes were significantly higher in GC patient compared with control individuals (OR= 1.77, 95% CI= 1.077-2.931; P=0.026). Allele distribution was similar in patients and healthy individuals (p = 0.061).Frequency of C and T alleles was 74.7%, 25.3% in control individuals and 68.03% and 31.97% in gastric cancer patients respectively. These results suggest that PD-1.5 C/T polymorphism may affect the GC risk and prognosis in an Iranian population.

Assessing the Impact of an Emotion Regulation Booster Program for Elementary School-Aged Children

ERIC Educational Resources Information Center

Hammond, Angela; Westhues, Anne; Hanbidge, Alice Schmidt

2009-01-01

The purpose of this study was to determine whether children who participated in a booster program 3 years after completing an emotion regulation program show a greater increase between pretest and post-test in the development of emotion regulation skills than children in a comparison group. A booster program was implemented as a pilot project with…

48 CFR 1301.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations... DEPARTMENT OF COMMERCE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 1301.403 Individual deviations. The designee authorized to approve individual deviations from the FAR is set forth in CAM 1301.70. ...

48 CFR 301.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 301... ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.403 Individual deviations. Contracting activities shall prepare requests for individual deviations to either the FAR or HHSAR in accordance with 301.470. ...

48 CFR 3001.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Individual deviations... from the FAR and HSAR 3001.403 Individual deviations. Unless precluded by law, executive order, or other regulation, the HCA is authorized to approve individual deviation (except with respect to (FAR) 48...

48 CFR 1201.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations... FEDERAL ACQUISITION REGULATIONS SYSTEM 70-Deviations From the FAR and TAR 1201.403 Individual deviations... Executive Service (SES) official or that of a Flag Officer, may authorize individual deviations (unless (FAR...

48 CFR 1901.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 1901.403 Section 1901.403 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL... Individual deviations. Deviations from the IAAR or the FAR in individual cases shall be authorized by the...

48 CFR 828.203 - Acceptability of individual sureties.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acceptability of individual sureties. 828.203 Section 828.203 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... Acceptability of individual sureties. ...

Emotion regulation in Asperger's syndrome and high-functioning autism.

PubMed

Samson, Andrea C; Huber, Oswald; Gross, James J

2012-08-01

It is generally thought that individuals with Asperger's syndrome and high-functioning autism (AS/HFA) have deficits in theory of mind. These deficits have been previously linked to problems with social cognition. However, we reasoned that AS/HFA individuals' Theory of Mind deficits also might lead to problems with emotion regulation. To assess emotional functioning in AS/HFA, 27 AS/HFA adults (16 women) and 27 age-, gender-, and education-matched typically developing (TD) participants completed a battery of measures of emotion experience, labeling, and regulation. With respect to emotion experience, individuals with AS/HFA reported higher levels of negative emotions, but similar levels of positive emotions, compared with TD individuals. With respect to emotion labeling, individuals with AS/HFA had greater difficulties identifying and describing their emotions, with approximately two-thirds exceeding the cutoff for alexithymia. With respect to emotion regulation, individuals with AS/HFA used reappraisal less frequently than TD individuals and reported lower levels of reappraisal self-efficacy. Although AS/HFA individuals used suppression more frequently than TD individuals, no difference in suppression self-efficacy was found. It is important to note that these differences in emotion regulation were evident even when controlling for emotion experience and labeling. Implications of these deficits are discussed, and future research directions are proposed.

Lifestyle Change Plus Dental Care (LCDC) program improves knowledge, attitude, and practice (KAP) toward oral health and diabetes mellitus among the elderly with type 2 diabetes.

PubMed

Saengtipbovorn, Saruta; Taneepanichskul, Surasak

2015-03-01

Currently, there is an increased prevalence of diabetes mellitus among the elderly. Chronic inflammation from diabetes mellitus effects glycemic control and increases risk of diabetes complications. To assess the effectiveness of a Lifestyle Change plus Dental Care (LCDC) program by improved knowledge, attitude, and practice (KAP) toward oral health and diabetes mellitus among the elderly with type 2 diabetes. A quasi-experimental study was conducted in two Health Centers (HC 54 intervention and HC 59 control) between October 2013 and April 2014. Sixty-six diabetic patients per health center were recruited. At baseline, the intervention group attended a 20-minute lifestyle and oral health education program, individual lifestyle counseling using motivational interviewing, application of self-regulation manual, and individual oral hygiene instruction. At 3-month follow-up, the intervention group received individual lifestyle counseling and oral hygiene instruction. The intervention group received booster education every visit by viewing a 15-minute educational video. The control group received the routine program. Participants were assessed at baseline, 3-month, and 6-month follow-up for knowledge, attitude, and practice (KAP) toward oral health and diabetes mellitus. Data was analyzed by using descriptive statistic, Chi-square test, Fisher's exact test, and repeated measure ANOVA. After the 6-month follow-up, repeated measure ANOVA analysis showed that participants in the intervention group had significantly higher knowledge and attitude toward oral health and diabetes mellitus. The participants in the intervention group were more likely to exercise, modify diet, have foot examinations, always wear covered shoes, participate in self-feet screening, use dental floss, and use inter-proximal brush than the control group with statistically significant differences. The combination of lifestyle change and dental care in one program improved knowledge, attitude, andpractice (KAP) toward oral health and diabetes mellitus in the elderly with type 2 diabetes. Trial registration: ClinicalTrials.in.th: TCTR20140602001.

48 CFR 519.7016 - Program review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Program review. 519.7016 Section 519.7016 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7016 Program review. At the conclusion of...

Compliance Groundwater Monitoring of Nonpoint Sources - Emerging Approaches

NASA Astrophysics Data System (ADS)

Harter, T.

2008-12-01

Groundwater monitoring networks are typically designed for regulatory compliance of discharges from industrial sites. There, the quality of first encountered (shallow-most) groundwater is of key importance. Network design criteria have been developed for purposes of determining whether an actual or potential, permitted or incidental waste discharge has had or will have a degrading effect on groundwater quality. The fundamental underlying paradigm is that such discharge (if it occurs) will form a distinct contamination plume. Networks that guide (post-contamination) mitigation efforts are designed to capture the shape and dynamics of existing, finite-scale plumes. In general, these networks extend over areas less than one to ten hectare. In recent years, regulatory programs such as the EU Nitrate Directive and the U.S. Clean Water Act have forced regulatory agencies to also control groundwater contamination from non-incidental, recharging, non-point sources, particularly agricultural sources (fertilizer, pesticides, animal waste application, biosolids application). Sources and contamination from these sources can stretch over several tens, hundreds, or even thousands of square kilometers with no distinct plumes. A key question in implementing monitoring programs at the local, regional, and national level is, whether groundwater monitoring can be effectively used as a landowner compliance tool, as is currently done at point-source sites. We compare the efficiency of such traditional site-specific compliance networks in nonpoint source regulation with various designs of regional nonpoint source monitoring networks that could be used for compliance monitoring. We discuss advantages and disadvantages of the site vs. regional monitoring approaches with respect to effectively protecting groundwater resources impacted by nonpoint sources: Site-networks provide a tool to enforce compliance by an individual landowner. But the nonpoint source character of the contamination and its typically large spatial extend requires extensive networks at an individual site to accurately and fairly monitor individual compliance. In contrast, regional networks seemingly fail to hold individual landowners accountable. But regional networks can effectively monitor large-scale impacts and water quality trends; and thus inform regulatory programs that enforce management practices tied to nonpoint source pollution. Regional monitoring networks for compliance purposes can face significant challenges in the implementation due to a regulatory and legal landscape that is exclusively structured to address point sources and individual liability, and due to the non-intensive nature of a regional monitoring program (lack of control of hot spots; lack of accountability of individual landowners).

William D. Ford Federal Direct Loan Program. Final Regulations. Federal Register, Department of Education, 34 CFR Part 685

ERIC Educational Resources Information Center

National Archives and Records Administration, 2014

2014-01-01

The purpose of this regulatory action is to amend the regulations governing the William D. Ford Federal Direct Loan (Direct Loan) Program (§ 685.200 of title 34 of the Code of Federal Regulations (CFR)). These regulations strengthen and improve administration of the Federal Direct PLUS Loan Program authorized under title IV of the Higher Education…

48 CFR 2801.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2801... OF JUSTICE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR and JAR 2801.403 Individual deviations. Individual deviations from the FAR or the JAR shall be approved by the head of the contracting...

48 CFR 401.403 - Individual deviations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 401... AGRICULTURE ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.403 Individual deviations. In individual cases, deviations from either the FAR or the AGAR will be authorized only when essential to effect...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

A mandala of faculty development: using theory-based evaluation to explore contexts, mechanisms and outcomes.

PubMed

Onyura, Betty; Ng, Stella L; Baker, Lindsay R; Lieff, Susan; Millar, Barbara-Ann; Mori, Brenda

2017-03-01

Demonstrating the impact of faculty development, is an increasingly mandated and ever elusive goal. Questions have been raised about the adequacy of current approaches. Here, we integrate realist and theory-driven evaluation approaches, to evaluate an intensive longitudinal program. Our aim is to elucidate how faculty development can work to support a range of outcomes among individuals and sub-systems in the academic health sciences. We conducted retrospective framework analysis of qualitative focus group data gathered from 79 program participants (5 cohorts) over a 10-year period. Additionally, we conducted follow-up interviews with 15 alumni. We represent the interactive relationships among contexts, mechanisms, and outcomes as a "mandala" of faculty development. The mandala illustrates the relationship between the immediate program context, and the broader institutional context of academic health sciences, and identifies relevant change mechanisms. Four primary mechanisms were collaborative-reflection, self-reflection and self-regulation, relationship building, and pedagogical knowledge acquisition. Individual outcomes, including changed teaching practices, are described. Perhaps most interestingly, secondary mechanisms-psychological and structural empowerment-contributed to institutional outcomes through participants' engagement in change leadership in their local contexts. Our theoretically informed evaluation approach models how faculty development, situated in appropriate institutional contexts, can trigger mechanisms that yield a range of benefits for faculty and their institutions. The adopted methods hold potential as a way to demonstrate the often difficult-to-measure outcomes of educational programs, and allow for critical examination as to how and whether faculty development programs can accomplish their espoused goals.

Self-regulation and selective exposure: the impact of depleted self-regulation resources on confirmatory information processing.

PubMed

Fischer, Peter; Greitemeyer, Tobias; Frey, Dieter

2008-03-01

In the present research, the authors investigated the impact of self-regulation resources on confirmatory information processing, that is, the tendency of individuals to systematically prefer standpoint-consistent information to standpoint-inconsistent information in information evaluation and search. In 4 studies with political and economic decision-making scenarios, it was consistently found that individuals with depleted self-regulation resources exhibited a stronger tendency for confirmatory information processing than did individuals with nondepleted self-regulation resources. Alternative explanations based on processes of ego threat, cognitive load, and mood were ruled out. Mediational analyses suggested that individuals with depleted self-regulation resources experienced increased levels of commitment to their own standpoint, which resulted in increased confirmatory information processing. In sum, the impact of ego depletion on confirmatory information search seems to be more motivational than cognitive in nature.

Skipping meals and alcohol consumption. The regulation of energy intake and expenditure among weight loss participants.

PubMed

Carels, Robert A; Young, Kathleen M; Coit, Carissa; Clayton, Anna Marie; Spencer, Alexis; Wagner, Marissa

2008-11-01

Research suggests that specific eating patterns (e.g., eating breakfast) may be related to favorable weight status. This investigation examined the relationship between eating patterns (i.e., skipping meals; consuming alcohol) and weight loss treatment outcomes (weight loss, energy intake, energy expenditure, and duration of exercise). Fifty-four overweight or obese adults (BMI> or =27 kg/m(2)) participated in a self-help or therapist-assisted weight loss program. Daily energy intake from breakfast, lunch, dinner, and alcoholic beverages, total daily energy intake, total daily energy expenditure, physical activity, and weekly weight loss were assessed. On days that breakfast or dinner was skipped, or alcoholic beverages were not consumed, less total daily energy was consumed compared to days that breakfast, dinner, or alcoholic beverages were consumed. On days that breakfast or alcohol was consumed, daily energy expenditure (breakfast only) and duration of exercise were higher compared to days that breakfast or alcohol was not consumed. Individuals who skipped dinner or lunch more often had lower energy expenditure and exercise duration than individuals who skipped dinner or lunch less often. Individuals who consumed alcohol more often had high daily energy expenditure than individuals who consumed alcohol less often. Skipping meals or consuming alcoholic beverages was not associated with weekly weight loss. In this investigation, weight loss program participants may have compensated for excess energy intake from alcoholic beverages and meals with greater daily energy expenditure and longer exercise duration.

76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

...-AL92 Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of... that contractors have implemented the mandatory contractor business ethics program requirements. DATES... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

34 CFR 606.6 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF EDUCATION DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM General § 606.6 What regulations apply? The following regulations apply to the Developing Hispanic-Serving Institutions Program: (a) The... part 75 (Direct Grant Programs), except 34 CFR 75.128(a)(2) and 75.129(a) in the case of applications...

34 CFR 206.4 - What regulations apply to these programs?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What regulations apply to these programs? 206.4 Section 206.4 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION SPECIAL EDUCATIONAL PROGRAMS FOR STUDENTS WHOSE FAMILIES ARE...

34 CFR 692.3 - What regulations apply to the LEAP Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What regulations apply to the LEAP Program? 692.3 Section 692.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LEVERAGING EDUCATIONAL ASSISTANCE PARTNERSHIP PROGRAM...

34 CFR 607.6 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM General § 607.6 What regulations apply? The following regulations apply to the Strengthening Institutions Program: (a) The Education Department General...

34 CFR 607.6 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM General § 607.6 What regulations apply? The following regulations apply to the Strengthening Institutions Program: (a) The Education Department General...

34 CFR 607.6 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM General § 607.6 What regulations apply? The following regulations apply to the Strengthening Institutions Program: (a) The Education Department General...

48 CFR 1328.203-7 - Exclusion of individual sureties.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exclusion of individual sureties. 1328.203-7 Section 1328.203-7 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Exclusion of individual sureties. The designee authorized to exclude an individual from acting as a surety...

Implicit Beliefs about Emotion Regulation and Their Relations with Emotional Experiences among Chinese Adolescents

ERIC Educational Resources Information Center

Deng, Xinmei; Sang, Biao; Chen, Xinyin

2017-01-01

There is growing interest in understanding how beliefs about emotion regulation are related to individual emotional experiences. Extant studies have mainly focused on explicit beliefs about emotion regulation among individuals in Western societies. The current study examined implicit emotion regulation and explored their contributions to emotional…

48 CFR 719.271 - Agency program direction and operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Agency program direction and operation. 719.271 Section 719.271 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 719.271 Agency program direction and...

75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for Commercial... Balance of Payments Program for construction material that is commercial information technology. DATES..., Balance of Payments Program--Construction Material, and 252.225- 7045, Balance of Payments Program...

48 CFR 719.271 - Agency program direction and operation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Agency program direction and operation. 719.271 Section 719.271 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 719.271 Agency program direction and...

Automatic Facial Expression Recognition and Operator Functional State

NASA Technical Reports Server (NTRS)

Blanson, Nina

2012-01-01

The prevalence of human error in safety-critical occupations remains a major challenge to mission success despite increasing automation in control processes. Although various methods have been proposed to prevent incidences of human error, none of these have been developed to employ the detection and regulation of Operator Functional State (OFS), or the optimal condition of the operator while performing a task, in work environments due to drawbacks such as obtrusiveness and impracticality. A video-based system with the ability to infer an individual's emotional state from facial feature patterning mitigates some of the problems associated with other methods of detecting OFS, like obtrusiveness and impracticality in integration with the mission environment. This paper explores the utility of facial expression recognition as a technology for inferring OFS by first expounding on the intricacies of OFS and the scientific background behind emotion and its relationship with an individual's state. Then, descriptions of the feedback loop and the emotion protocols proposed for the facial recognition program are explained. A basic version of the facial expression recognition program uses Haar classifiers and OpenCV libraries to automatically locate key facial landmarks during a live video stream. Various methods of creating facial expression recognition software are reviewed to guide future extensions of the program. The paper concludes with an examination of the steps necessary in the research of emotion and recommendations for the creation of an automatic facial expression recognition program for use in real-time, safety-critical missions

Automatic Facial Expression Recognition and Operator Functional State

NASA Technical Reports Server (NTRS)

Blanson, Nina

2011-01-01

The prevalence of human error in safety-critical occupations remains a major challenge to mission success despite increasing automation in control processes. Although various methods have been proposed to prevent incidences of human error, none of these have been developed to employ the detection and regulation of Operator Functional State (OFS), or the optimal condition of the operator while performing a task, in work environments due to drawbacks such as obtrusiveness and impracticality. A video-based system with the ability to infer an individual's emotional state from facial feature patterning mitigates some of the problems associated with other methods of detecting OFS, like obtrusiveness and impracticality in integration with the mission environment. This paper explores the utility of facial expression recognition as a technology for inferring OFS by first expounding on the intricacies of OFS and the scientific background behind emotion and its relationship with an individual's state. Then, descriptions of the feedback loop and the emotion protocols proposed for the facial recognition program are explained. A basic version of the facial expression recognition program uses Haar classifiers and OpenCV libraries to automatically locate key facial landmarks during a live video stream. Various methods of creating facial expression recognition software are reviewed to guide future extensions of the program. The paper concludes with an examination of the steps necessary in the research of emotion and recommendations for the creation of an automatic facial expression recognition program for use in real-time, safety-critical missions.

Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease.

PubMed

Zapata-Martín Del Campo, Carlos Manuel; Martínez-Rosas, Martín; Guarner-Lans, Verónica

2018-04-18

Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD). The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual.

Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

PubMed Central

Zapata-Martín del Campo, Carlos Manuel; Martínez-Rosas, Martín

2018-01-01

Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD). The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual. PMID:29670001

Resident work-hour rules: a survey of residents' and program directors' opinions and attitudes.

PubMed

Immerman, Igor; Kubiak, Erik N; Zuckerman, Joseph D

2007-12-01

In July 2003, the Accreditation Council for Graduate Medical Education (ACGME) established nationwide guidelines for resident working environments and duty hours. Following these guidelines became a requirement for all accredited residency programs. Two years after implementation, we conducted a national survey to assess the opinions and attitudes of orthopedic residents and program directors toward the ACGME work-hour regulations and the effects of these regulations on resident education, resident quality of life, and patient care. Nine hundred seventy-six residents (30% response rate) and 85 program directors (56% response rate) completed the questionnaire. For resident education, junior residents were more likely than senior residents and program directors to perceive the work-hour regulations as having a positive effect on education. There was overall agreement among the 3 groups that resident quality of life had improved as a result of work-hour regulations. For patient care, junior residents viewed the new regulations positively for surgical training and patient care, whereas senior residents and program directors disagreed. This survey showed meaningful differences in the attitudes and opinions of junior residents, senior residents, and program directors toward the new ACGME work-hour regulations.

7 CFR 3570.91 - Regulations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Regulations. 3570.91 Section 3570.91 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.91 Regulations. Grants under this part will be...

7 CFR 3570.91 - Regulations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Regulations. 3570.91 Section 3570.91 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.91 Regulations. Grants under this part will be...

A randomized, single-blind cross-over design evaluating the effectiveness of an individually defined, targeted physical therapy approach in treatment of children with cerebral palsy.

PubMed

Franki, Inge; Van den Broeck, Christine; De Cat, Josse; Tijhuis, Wieke; Molenaers, Guy; Vanderstraeten, Guy; Desloovere, Kaat

2014-10-01

A pilot study to compare the effectiveness of an individual therapy program with the effects of a general physical therapy program. A randomized, single-blind cross-over design. Ten ambulant children with bilateral spastic cerebral palsy, age four to nine years. Participants were randomly assigned into a ten-week individually defined, targeted or a general program, followed by a cross-over. Evaluation was performed using the Gross Motor Function Measure-88 and three-dimensional gait analysis. General outcome parameters were Gross Motor Function Measure-88 scores, time and distance parameters, gait profile score and movement analysis profiles. Individual goal achievement was evaluated using z-scores for gait parameters and Goal Attainment Scale for gross motor function. No significant changes were observed regarding gross motor function. Only after individualized therapy, step- and stride-length increased significantly (p = 0.022; p = 0.017). Change in step-length was higher after the individualized program (p = 0.045). Within-group effects were found for the pelvis in transversal plane after the individualized program (p = 0.047) and in coronal plane after the general program (p = 0.047). Between-program differences were found for changes in the knee in sagittal plane, in the advantage of the individual program (p = 0.047). A median difference in z-score of 0.279 and 0.419 was measured after the general and individualized program, respectively. Functional goal attainment was higher after the individual therapy program compared with the general program (48 to 43.5). The results indicate slightly favorable effects towards the individualized program. To detect clinically significant changes, future studies require a minimal sample size of 72 to 90 participants. © The Author(s) 2014.