Sample records for program whk sip

  1. WHK Student Internship Enrollment, Mentor Participation Up More than 50 Percent | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer The Werner H. Kirsten Student Internship Program (WHK SIP) has enrolled the largest class ever for the 2013–2014 academic year, with 66 students and 50 mentors. This enrollment reflects a 53 percent increase in students and a 56 percent increase in mentors, compared to 2012–2013 (43 students and 32 mentors), according to Julie Hartman, WHK SIP director.

  2. WHK Student Internship Enrollment, Mentor Participation Up More than 50 Percent | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer The Werner H. Kirsten Student Internship Program (WHK SIP) has enrolled the largest class ever for the 2013–2014 academic year, with 66 students and 50 mentors. This enrollment reflects a 53 percent increase in students and a 56 percent increase in mentors, compared to 2012–2013 (43 students and 32 mentors), according to Julie Hartman, WHK SIP

  3. Celebrating 25 Years of Student Mentoring | Poster

    Cancer.gov

    Most employees of NCI at Frederick have heard of the Werner H. Kirsten Student Intern Program (WHK SIP). The reason is simple—it has been wildly successful. And on Friday, April 22, the program will celebrate 25 years of mentoring and learning at the WHK SIP 25th Anniversary Symposium and Awards Ceremony. During the morning session, several former interns will talk about the

  4. Celebrating 25 Years of Student Mentoring | Poster

    Cancer.gov

    Most employees of NCI at Frederick have heard of the Werner H. Kirsten Student Intern Program (WHK SIP). The reason is simple—it has been wildly successful. And on Friday, April 22, the program will celebrate 25 years of mentoring and learning at the WHK SIP 25th Anniversary Symposium and Awards Ceremony. During the morning session, several former interns will talk about the impact that the WHK program has had on their lives. The afternoon session will begin with a panel of current and former mentors who will answer questions from students interested in the program and staff members interested in becoming mentors. Read more...

  5. How Great Is Your Student Intern? | Poster

    Cancer.gov

    Editor’s note: We asked Werner H. Kirsten Student Internship Program (WHK SIP) mentors to tell us about the unique and diverse backgrounds of some of this year’s student interns. Alex Beall Microarray Group, Genomics Laboratory, Cancer Research Technology Program Mentors: Nicole Shrader and Stephanie Mellott, research associates

  6. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical

  7. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical research experience for local high school seniors.

  8. Reflections on My Werner H. Kirsten Student Internship | Poster

    Cancer.gov

    By Nathalie Walker, Guest Writer Editor’s note: This article represents one student’s perspective on her experiences as a Werner H. Kirsten student intern. Failure isn’t just a possibility, it is a certainty; yet failure is what leads you to success. Above all else, that is what I will retain from my experience in the Werner H. Kirsten Student Intern Program (WHK SIP).

  9. Poster Day Showcases Student Work | Poster

    Cancer.gov

    By Nathalie Walker, Guest Writer, and Carolynne Keenan, Contributing Writer On July 31, NCI at Frederick hosted Student Poster Day, an annual event in which student interns can showcase the work they do in their various positions in NCI at Frederick labs and offices. Participating students are interns in the Student Internship Program, a program designed for undergraduate and graduate students during their summer breaks, as well as interns in the Werner H. Kirsten Student Internship Program (WHK SIP), a program for high school seniors. All the students have an opportunity to present their scientific posters.

  10. Where Are They Now: Former WHK Intern Julianne Heberlein Moves from Science to Politics | Poster

    Cancer.gov

    Former Werner H. Kirsten (WHK) intern Julianne Heberlein—who worked in the Frederick National Laboratory Public Affairs and Communication Office under Frank Blanchard—credits the WHK program with setting her apart from other applicants when applying for her recent internships.

  11. Where Are They Now: Janine Bahsali’s Journey from Researcher to Counselor and Beyond | Poster

    Cancer.gov

    Former Werner H. Kirsten (WHK) intern Janine Bahsali, who will be attending Adler University this fall to pursue a doctorate in clinical psychology, credits her internships at NCI at Frederick with starting her down the path toward a Ph.D. Bahsali joined the WHK Student Intern Program during her senior year of high school, working in Occupational Health Services with mentor

  12. Evaluating the effectiveness of the Safety Investment Program (SIP) policies for Oregon.

    DOT National Transportation Integrated Search

    2009-10-01

    The Safety Investment Program (SIP) was originally called the Statewide Transportation Improvement Program - : Safety Investment Program (STIP-SIP). The concept of the program was first discussed in October 1997 and the : program was adopted by the O...

  13. Review of Physics Research Programs at LAMPF. Progress report, January-December 1983

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allred, J.C.

    1984-04-01

    Research and development summaries are presented under the main headings: research, proton storage ring construction and research program development, status of LAMPF II, facility and experimental development, and accelerator operations. Complete lists are given for experiments run in 1983, new prospects, and active and complete experiments by channel. (WHK)

  14. Ocean Thermal Energy Conversion power system development. Phase I: preliminary design. Final report. [ODSP-3 code; OTEC Steady-State Analysis Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1978-12-04

    The following appendices are included; Dynamic Simulation Program (ODSP-3); sample results of dynamic simulation; trip report - NH/sub 3/ safety precautions/accident records; trip report - US Coast Guard Headquarters; OTEC power system development, preliminary design test program report; medium turbine generator inspection point program; net energy analysis; bus bar cost of electricity; OTEC technical specifications; and engineer drawings. (WHK)

  15. Physics Division progress report for period ending September 30, 1983

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1983-12-01

    Research and development activities are summarized in the following areas: Holifield Heavy Ion Research Facility, nuclear physics, the UNISOR program, accelerator-based atomic physics, theoretical physics, nuclear science applications, atomic physics and plasma diagnostics for fusion program, high-energy physics, the nuclear data project, and the relativistic heavy-ion collider study. Publications and papers presented are listed. (WHK)

  16. Computer program for nonlinear static stress analysis of shuttle thermal protection system: User's manual

    NASA Technical Reports Server (NTRS)

    Giles, G. L.; Wallas, M.

    1981-01-01

    User documentation is presented for a computer program which considers the nonlinear properties of the strain isolator pad (SIP) in the static stress analysis of the shuttle thermal protection system. This program is generalized to handle an arbitrary SIP footprint including cutouts for instrumentation and filler bar. Multiple SIP surfaces are defined to model tiles in unique locations such as leading edges, intersections, and penetrations. The nonlinearity of the SIP is characterized by experimental stress displacement data for both normal and shear behavior. Stresses in the SIP are calculated using a Newton iteration procedure to determine the six rigid body displacements of the tile which develop reaction forces in the SIP to equilibrate the externally applied loads. This user documentation gives an overview of the analysis capabilities, a detailed description of required input data and an example to illustrate use of the program.

  17. Physics Division progress report for period ending June 30, 1981

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1981-11-01

    Progress is reported in detail in the following areas: Holifield Heavy-Ion Research Facility, nuclear physics, the UNISOR program, neutron physics, theoretical physics, the Nuclear Data Project, atomic and plasma physics, and high energy physics. Publications are listed. Separate abstracts were prepared for 34 papers. (WHK)

  18. SIP: A Web-Based Astronomical Image Processing Program

    NASA Astrophysics Data System (ADS)

    Simonetti, J. H.

    1999-12-01

    I have written an astronomical image processing and analysis program designed to run over the internet in a Java-compatible web browser. The program, Sky Image Processor (SIP), is accessible at the SIP webpage (http://www.phys.vt.edu/SIP). Since nothing is installed on the user's machine, there is no need to download upgrades; the latest version of the program is always instantly available. Furthermore, the Java programming language is designed to work on any computer platform (any machine and operating system). The program could be used with students in web-based instruction or in a computer laboratory setting; it may also be of use in some research or outreach applications. While SIP is similar to other image processing programs, it is unique in some important respects. For example, SIP can load images from the user's machine or from the Web. An instructor can put images on a web server for students to load and analyze on their own personal computer. Or, the instructor can inform the students of images to load from any other web server. Furthermore, since SIP was written with students in mind, the philosophy is to present the user with the most basic tools necessary to process and analyze astronomical images. Images can be combined (by addition, subtraction, multiplication, or division), multiplied by a constant, smoothed, cropped, flipped, rotated, and so on. Statistics can be gathered for pixels within a box drawn by the user. Basic tools are available for gathering data from an image which can be used for performing simple differential photometry, or astrometry. Therefore, students can learn how astronomical image processing works. Since SIP is not part of a commercial CCD camera package, the program is written to handle the most common denominator image file, the FITS format.

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harrison, T.D.

    Sandia National Laboratories, Albuquerque (SNLA), is currently conducting a program to predict the performance and measure the characteristics of commercially available solar collectors that have the potential for use in industrial process heat and enhance oil recovery applications. The thermal performance predictions for the AAI solar line-focusing slat-type collector for five cities in the US are presented. (WHK)

  20. 77 FR 62200 - Approval and Promulgation of Implementation Plans; New Mexico; Revisions to the New Source Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ... Plan (SIP); Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NNSR... approve revisions to the New Mexico SIP to update the New Mexico NNSR and PSD SIP permitting programs.... New Mexico submitted the PSD and NNSR SIP permitting revisions in two SIP submittals on June 11, 2009...

  1. 78 FR 4339 - Approval and Promulgation of Implementation Plans; New Mexico; Revisions to the New Source Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Plan (SIP); Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NNSR... revisions to the New Mexico SIP to update the New Mexico NNSR and PSD SIP permitting programs consistent... submitted the PSD and NNSR SIP permitting revisions in two SIP submittals on June 11, 2009 and May 23, 2011...

  2. 78 FR 21281 - Approval and Promulgation of Implementation Plans; State of Missouri; Infrastructure SIP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...EPA is proposing action on four Missouri State Implementation Plan (SIP) submissions. First, EPA is proposing to approve portions of two SIP submissions from the State of Missouri addressing the applicable requirements of Clean Air Act (CAA) for the 1997 and 2006 National Ambient Air Quality Standards (NAAQS) for fine particulate matter (PM2.5). The CAA requires that each state adopt and submit a SIP to support implementation, maintenance, and enforcement of each new or revised NAAQS promulgated by EPA. These SIPs are commonly referred to as ``infrastructure'' SIPs. The infrastructure requirements are designed to ensure that the structural components of each state's air quality management program are adequate to meet the state's responsibilities under the CAA. EPA is also proposing to approve two additional SIP submissions from Missouri, one addressing the Prevention of Significant Deterioration (PSD) program in Missouri, and another addressing the requirements applicable to any board or body which approves permits or enforcement orders of the CAA, both of which support requirements associated with infrastructure SIPs.

  3. WHK Interns Highlight the Importance of Their Work | Poster

    Cancer.gov

    The Werner H. Kirsten (WHK) student interns at the National Cancer Institute (NCI) at Frederick are participating in groundbreaking cancer research, along with large-scale projects and technological advancements, during their senior year of high school. The interns at NCI at Frederick are given more than the opportunity to watch the research; they participate in and conduct

  4. 75 FR 19467 - Approval and Promulgation of Implementation Plans; Texas; Revisions to the New Source Review (NSR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ...EPA is taking final action to disapprove revisions to the SIP submitted by the State of Texas that relate to the Modification of Existing Qualified Facilities (the Qualified Facilities Program or the Program). EPA is disapproving the Texas Qualified Facilities Program because it does not meet the Minor NSR SIP requirements nor does it meet the NSR SIP requirements for a substitute Major NSR SIP revision. EPA is also approving three definitions that are severable from the Qualified Facilities submittals. These three definitions we are approving are, ``grandfathered facility,'' ``maximum allowable emission rate table (MAERT),'' and ``new facility.'' Moreover, we are making an administrative correction to the SIP-approved definition of ``facility.'' We are taking this action under section 110, part C, and part D of the Federal Clean Air Act (the Act or CAA).

  5. 77 FR 36964 - Approval and Promulgation of Implementation Plans; Texas; Revisions to the New Source Review (NSR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ...EPA is proposing to approve revisions to the SIP for the State of Texas that relate to antibacksliding of Major NSR SIP Requirements for the one-hour ozone NAAQS; Major NNSR SIP requirements for the 1997 eight-hour ozone NAAQS; Major NSR Reform Program with Plantwide Applicability Limit (PAL) provisions; and non-PAL aspects of the Major NSR SIP requirements. EPA proposes to find that these changes to the Texas SIP comply with the Federal Clean Air Act (the Act or CAA) and EPA regulations and are consistent with EPA policies. Texas submitted revisions to these programs on June 10, 2005, and February 1, 2006. EPA disapproved these SIP revisions on September 15, 2010 (75 FR 56424). In response to the 2010 disapproval, Texas submitted revisions to these programs in two separate SIP submittals on March 11, 2011. These SIP submittals include resubmittal of the rules that were previously submitted June 10, 2005, and February 1, 2006, and subsequently disapproved by EPA on September 15, 2010. On February 22, 2012, Texas proposed further revisions to the NSR Reform Program to further clarify and ensure compliance with Federal requirements relating to NSR Reform. On May 3, 2012, Texas provided a letter to EPA which requested that EPA parallel process the revisions proposed February 22, 2012, and included a demonstration showing how its submitted rules are at least as stringent as the Federal NSR Reform Program. Texas has requested that EPA parallel process the revisions proposed February 22, 2012, and consider the May 3, 2012, letter in the review of the March 11, 2011, SIP submittals. Today, EPA is proposing to find that the March 11, 2011, SIP submittals; the February 22, 2012, proposed revisions; and the May 3, 2012, letter, address each of the grounds for EPA's September 15, 2010, disapproval and other issues related to the Texas NSR Reform revisions as identified later. Accordingly, EPA proposes to approve these two March 11, 2011, revisions; the February 22, 2012, proposed revisions for which Texas has requested parallel processing; and the May 3, 2012, letter as part of the Texas NSR SIP. EPA is proposing this action under section 110 and parts C and D of the Act.

  6. Where Are They Now: Nathalie Walker Moves from Science to Activism and Art Communications | Poster

    Cancer.gov

    Whether it’s in a flowerbed or an art gallery, former Werner H. Kirsten (WHK) student intern Nathalie Walker can’t help but to cause a buzz. Since completing her WHK internship in the summer of 2015, Walker has been attending Loyola University Maryland, where she is striving to make a positive impact on campus.

  7. Lateral load performance of SIP walls with full bearing

    Treesearch

    Boren Yeh; Tom Skaggs; Xiping Wang; Tom Williamson

    2018-01-01

    The purpose of this study was to develop test data needed to characterize lateral load performance of structural insulated panel (SIP) walls with full bearing (restrained). The research program involved structural testing of 29 full-size SIP walls (8 ft tall by 8 ft long) of various configurations that bracket a range of SIP wall configurations commonly used in the...

  8. Thermoelectric materials evaluation program. Technical summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hinderman, J.D.

    1979-04-01

    Research progress on the thermoelectric materials evaluation program is reported covering the period January 1, 1976 to September 30, 1978. Topical reports are presented on (1) hot and cold end ..delta..T's, (2) hardware mobility, (3) p-leg sublimation suppression, (4) thermodynamic stability of p-legs, (5) n-leg material process improvements to reduce extraneous resistance, (6) n-leg cracking, (7) dynamic evaluation of converter, and (8) data base and degradation modes. Twenty attachments are included which present supporting drawings, specifications, procedures, and data. (WHK)

  9. 76 FR 48002 - Approval and Promulgation of Air Quality Implementation Plans; State of California; Interstate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ...EPA is finalizing a limited approval and limited disapproval of a state implementation plan (SIP) revision submitted by the State of California on November 17, 2007, to address the ``transport SIP'' provisions of Clean Air Act (CAA) section 110(a)(2)(D)(i) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each SIP contain, among other things, adequate measures prohibiting emissions of air pollutants in amounts which will interfere with any other State's measures required under title I, part C of the CAA to prevent significant deterioration of air quality. EPA is approving California's SIP revision with respect to those Districts that implement SIP- approved permit programs meeting the approval criteria and simultaneously disapproving California's SIP revision with respect to those Districts that do not implement SIP-approved permit programs meeting the approval criteria, as discussed in our May 31, 2011 proposed rule (76 FR 31263).

  10. 1997 SOUTH CAROLINA EPA/EPSCOR PROGRAM—STRATEGIC IMPROVEMENT PLAN (SIP) AND MANAGEMENT

    EPA Science Inventory

    The SIP of the 1997 South Carolina EPA/EPSCoR Program encompasses the educational programs and management components.  The educational activities are addressed in terms of pre-college, undergraduate, graduate, and public science programs.  These results are summarized bel...

  11. 46 CFR 8.540 - Enrollment in SIP.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Streamlined Inspection Program § 8.540 Enrollment in SIP. Upon successful completion of the training and evaluation phase, the Coast Guard SIP Advisor will recommend to the OCMI that the company or...

  12. Incorporating Voluntary Mobile Source Emission Reduction Programs in State Implementation Plans (SIPs)

    EPA Pesticide Factsheets

    This EPA memorandum provides guidance and sets forth policy and interpretation regarding the granting of explicit State Implementation Plan (SIP) credit for Voluntary Mobile Source Emission Reduction Programs (VMEPs) under section 110 of the Clean Air Act.

  13. 77 FR 11744 - Approval and Promulgation of Implementation Plans; Tennessee: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... New Source Review (NSR) Prevention of Significant Deterioration (PSD) program. Specifically, the SIP... modification projects become subject to Tennessee's PSD permitting requirements for GHG emissions. This rule... thresholds in the Tennessee SIP for GHG PSD requirements. EPA is approving Tennessee's January 11, 2012, SIP...

  14. 78 FR 2354 - Approval and Promulgation of Air Quality Implementation Plans; Arkansas; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ...) Prevention of Significant Deterioration (PSD) program updates the Arkansas SIP to incorporate by reference (IBR) requirements for the Federal PSD permitting program under EPA's November 29, 2005 Phase 2 8-hour Ozone Implementation rule. The November 6, 2012 proposed SIP revision to the Arkansas NSR PSD program...

  15. 78 FR 19596 - Approval and Promulgation of Air Quality Implementation Plans; Arkansas; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ...) Prevention of Significant Deterioration (PSD) program updates the Arkansas SIP to incorporate by reference (IBR) requirements for the federal PSD permitting program under EPA's November 29, 2005 Phase 2 8-hour Ozone Implementation rule. The November 6, 2012, SIP revision to the Arkansas NSR PSD program provides...

  16. 76 FR 66269 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... Title: Salmonella Initiative Program. OMB Control Number: 0583-New. Summary of Collection: The Food... and packaged. The Salmonella initiative Program (SIP) offers incentives to meat and poultry slaughter establishments to control Salmonella in their operations. SIP benefits public health because it encourages...

  17. DOE/JPL advanced thermionic technology program

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Accomplishments in the DOE program include: continuing stable output from the combustion life test of the one-inch diameter hemispherical silicon carbine diode (Converter No. 239) at an emitter temperature of 1730 K for a period of over 4200 hours; construction of four diode module completed; favorable results obtained from TAM combustor-gas turbine system analyses; and obtained a FERP work function of 2.3 eV with the W(100)-O-Zr-C electrode. JPL program accomplishments include: the average minimum barrier index of the last six research diodes built with sublimed molybdenum oxide collectors was 20 eV (WHK).

  18. Former WHK Intern Returns to NCI at Frederick as Earl-Stadtman Investigator | Poster

    Cancer.gov

    The Laboratory of Cell and Developmental Signaling (LCDS) recently welcomed John Brognard, Ph.D., as the new Earl-Stadtman Investigator. While Brognard is new to this role, he is not new to NCI at Frederick. In high school, Brognard was a Werner H. Kirsten Student Intern in what was formerly known as the ABL research program, where he worked under Bob Moschel, Ph.D., senior

  19. 40 CFR 52.331 - Committal SIP for the Colorado Group II PM10 areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PM10 areas. 52.331 Section 52.331 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.331 Committal SIP for the Colorado Group II PM10 areas. On April 14, 1989, the Governor submitted a Committal SIP...

  20. 40 CFR 52.331 - Committal SIP for the Colorado Group II PM10 areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PM10 areas. 52.331 Section 52.331 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.331 Committal SIP for the Colorado Group II PM10 areas. On April 14, 1989, the Governor submitted a Committal SIP...

  1. 40 CFR 52.331 - Committal SIP for the Colorado Group II PM10 areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PM10 areas. 52.331 Section 52.331 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.331 Committal SIP for the Colorado Group II PM10 areas. On April 14, 1989, the Governor submitted a Committal SIP...

  2. 40 CFR 52.331 - Committal SIP for the Colorado Group II PM10 areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PM10 areas. 52.331 Section 52.331 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.331 Committal SIP for the Colorado Group II PM10 areas. On April 14, 1989, the Governor submitted a Committal SIP...

  3. 40 CFR 52.331 - Committal SIP for the Colorado Group II PM10 areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PM10 areas. 52.331 Section 52.331 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Colorado § 52.331 Committal SIP for the Colorado Group II PM10 areas. On April 14, 1989, the Governor submitted a Committal SIP...

  4. 40 CFR 52.634 - Particulate matter (PM-10) Group III SIP.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.634 Particulate matter (PM-10) Group III SIP. (a) On September 14, 1988, the Governor of Hawaii submitted a revision to the... necessary to satisfy the requirements of the PM-10 Group III SIP. (b) The Hawaii Department of Health has...

  5. 77 FR 67596 - Approval and Promulgation of Air Quality Implementation Plans; Montana; Revisions to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... Proposed Action on SIP Revisions V. Summary of EPA's Proposed Action VI. Statutory and Executive Order... Program, unless the context indicates otherwise. (xi) The initials SIP mean or refer to State... September 23, 2011 the State of Montana submitted new rules and revisions to revise the Montana SIP. The...

  6. 78 FR 17108 - Approval and Promulgation of Implementation Plans; State of Washington; Revised Format for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Plan Section H. When a SIP Revision Becomes Federally Enforceable I. The Historical Record of SIP... business assistance programs. H. When a SIP Revision Becomes Federally Enforceable All revisions to the... Administrative Code, Chapter 173-430--Burning of Field and Forage and Turf Grasses Grown for Seed Open Burning...

  7. San Mateo County's Server Information Program (S.I.P.): A Community-Based Alcohol Server Training Program.

    ERIC Educational Resources Information Center

    de Miranda, John

    The field of alcohol server awareness and training has grown dramatically in the past several years and the idea of training servers to reduce alcohol problems has become a central fixture in the current alcohol policy debate. The San Mateo County, California Server Information Program (SIP) is a community-based prevention strategy designed to…

  8. 77 FR 24148 - Revision to the Hawaii State Implementation Plan, Minor New Source Review Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... Hawaii State Implementation Plan, Minor New Source Review Program AGENCY: Environmental Protection Agency... final action to approve revisions to the Hawaii State Implementation Plan (SIP). These revisions would update and replace the minor new source review rules that EPA approved into the Hawaii SIP in 1983. DATES...

  9. 76 FR 31263 - Approval and Promulgation of Implementation Plans; State of California; Interstate Transport of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ...EPA is proposing a limited approval and limited disapproval of a State Implementation Plan (``SIP'') revision submitted by the State of California on November 17, 2007, for the purpose of addressing the ``transport SIP'' provisions of Clean Air Act (``CAA'') section 110(a)(2)(D)(i) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (``PM2.5'') NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each SIP contain adequate provisions to prohibit emissions that adversely affect air quality in other States through interstate transport. EPA is proposing a limited approval and limited disapproval of California's SIP revision for the 1997 8-hour ozone and 1997 PM2.5 NAAQS with respect to the requirement in CAA section 110(a)(2)(D)(i)(II) that each SIP contain adequate measures prohibiting emissions of air pollutants in amounts which will interfere with other States' measures required under title I, part C of the CAA to prevent significant deterioration of air quality. Specifically, EPA is proposing to approve California's SIP revision with respect to those Districts in California that implement SIP-approved permit programs meeting the approval criteria under CAA section 110(a)(2)(D)(i), as discussed in this proposal. EPA is simultaneously proposing to disapprove California's SIP revision with respect to those Districts in California that do not implement SIP-approved permit programs meeting these approval criteria. For any District for which we finalize a disapproval, EPA intends to simultaneously promulgate a limited Federal Implementation Plan (``FIP''), as discussed in this proposal, unless the relevant area is already subject to a FIP.

  10. Energy Efficiency and Renewable Energy in SIPs and TIPs

    EPA Pesticide Factsheets

    Tools and guides to encourage state, tribal and local agencies to consider incorporating Energy Efficiency (EE) and Renewable Energy (RE) policies and programs in their State and Tribal Implementation Plans (SIPs/TIPs).

  11. 78 FR 68367 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Ohio NOX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... Clean Air Act, which allows for Ohio's Clean Air Interstate Rule (CAIR) NO X Ozone Season Trading Program rules to supersede Ohio's nitrogen oxides (NO X ) State Implementation Plan (SIP) Call Budget Trading Program rules, but leave other requirements of the NO X SIP Call in place for units not covered by...

  12. 75 FR 9103 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; NOX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... State Implementation Plan (SIP) that would terminate the provisions of the Nitrogen Oxides (NO X ) Budget Trading Program that apply to electric generating units. EPA is no longer operating the NO X Budget Trading Program as a compliance option under the NO X SIP Call. These sources are now subject to...

  13. 75 FR 9146 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; NOX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... Illinois State Implementation Plan (SIP) that would terminate the provisions of the Nitrogen Oxides (NO X ) Budget Trading Program that apply to electric generating units. EPA is no longer operating the NO X Budget Trading Program as a compliance option under the NO X SIP Call. These sources are now subject to...

  14. Former WHK Intern Returns to NCI at Frederick as Earl-Stadtman Investigator | Poster

    Cancer.gov

    The Laboratory of Cell and Developmental Signaling (LCDS) recently welcomed John Brognard, Ph.D., as the new Earl-Stadtman Investigator. While Brognard is new to this role, he is not new to NCI at Frederick. In high school, Brognard was a Werner H. Kirsten Student Intern in what was formerly known as the ABL research program, where he worked under Bob Moschel, Ph.D., senior investigator, and Gary Pauly, Ph.D., currently a staff scientist in the Chemical Biology Laboratory.

  15. 76 FR 32321 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Revision to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ...-day window allowed under the prior approved SIP. This SIP revision affects forty-two counties in... inspection stations in the forty-two non-I/M counties. The quality assurance program established a window...

  16. 36 CFR 230.7 - Program practices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... soil erosion. (5) Soil and Water Protection and Improvement (SIP5), which includes the maintenance or improvement of water quality and soil productivity on forest land. (6) Riparian and Wetland Protection and...) Forest and Agroforest Improvement (SIP3), which includes the improvement of forest and agroforest stand...

  17. 76 FR 43149 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... of Significant Deterioration (PSD) program to establish appropriate emission thresholds for... Mexico's December 1, 2010, proposed SIP revision establishes appropriate emissions thresholds for... appropriate thresholds for GHG permitting applicability into New Mexico's SIP, then paragraph (d) in Sec. 52...

  18. Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

  19. 76 FR 81836 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Albuquerque/Bernalillo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... Significant Deterioration (PSD) program to establish appropriate emission thresholds for determining which new stationary sources and modification projects become subject to Albuquerque/Bernalillo County's PSD permitting..., New Mexico December 15, 2010 PSD SIP revision because the Agency has determined that this PSD SIP...

  20. 76 FR 59334 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Albuquerque/Bernalillo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Prevention of Significant Deterioration (PSD) program to establish appropriate emission thresholds for... County's PSD permitting requirements for their greenhouse gas (GHG) emissions. Due to the SIP Narrowing Rule, 75 FR 82536, starting on January 2, 2011, the approved Albuquerque/Bernalillo County SIP's PSD...

  1. 40 CFR 52.634 - Particulate matter (PM-10) Group III SIP.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Particulate matter (PM-10) Group III SIP. 52.634 Section 52.634 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Hawaii § 52.634 Particulate matter...

  2. 40 CFR 52.146 - Particulate matter (PM-10) Group II SIP commitments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Particulate matter (PM-10) Group II SIP commitments. 52.146 Section 52.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.146 Particulate matter...

  3. 76 FR 79714 - Program for Allocation of Regulatory Responsibilities Pursuant to Rule 17d-2; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ...) the Consolidated Tape Association (``CTA'') as the exclusive securities information processor (``SIP... CHX Solely Listed Stocks and (b) the NASDAQ Unlisted Trading Privileges Plan as the exclusive SIP for... Property. (ii) Enhancements to Existing Intellectual Property or New Developments. In the event FINRA (a...

  4. 76 FR 20907 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... revision modifies New Mexico's Prevention of Significant Deterioration (PSD) program to establish... subject to New Mexico's PSD permitting requirements for their greenhouse gas (GHG) emissions. Due to the SIP Narrowing Rule, 75 FR 82536, starting on January 2, 2011, the approved New Mexico SIP's PSD...

  5. Sawmilling practices for hardwoods

    Treesearch

    John. Dramm

    2013-01-01

    The Sawmill Improvement Program (SIP) provides guidance to improve the bottom line of a sawmill both by recovering more lumber from a log and by using simplified procedures to produce more grade lumber. Lessons learned from SIP have led to improved yields of grade lumber through improved log manufacturing, reducing sawing variation by using thinner kerf saws and better...

  6. 78 FR 57501 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Amendments to Vehicle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...EPA is approving a state implementation plan (SIP) revision submitted by the Wisconsin Department of Natural Resources on June 7, 2012, concerning the state's vehicle inspection and maintenance (I/M) program in southeast Wisconsin. The revision amends I/M program requirements in the active control measures portion of the ozone SIP to reflect changes that have been implemented at the state level since EPA fully approved the I/M program on August 16, 2001. The submittal also includes a demonstration under section 110(l) of the Clean Air Act (CAA) addressing lost emission reductions associated with the program changes.

  7. 78 FR 68377 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Ohio NOX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ...On November 15, 2010, Ohio EPA submitted to EPA revisions to Ohio OAC 3745-14. EPA is proposing to approve these revisions under the Clean Air Act, which allows for Ohio's Clean Air Interstate Rule (CAIR) NOX Ozone Season Trading Program rules to supersede Ohio's nitrogen oxides (NOX) State Implementation Plan (SIP) Call Budget Trading Program rules, but leave other requirements of the NOX SIP Call in place for units not covered by CAIR.

  8. 78 FR 69812 - Approval and Promulgation of Implementation Plans; Texas; Control of Air Pollution by Permits for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ...EPA is proposing to approve portions of two revisions to the Texas State Implementation Plan (SIP) concerning the Permits for Specific Designated Facilities Program, also referred to as the FutureGen Program. EPA has determined that the portions of these SIP revisions specific to the FutureGen Program submitted on March 9, 2006 and July 2, 2010, comply with the Clean Air Act and EPA regulations and are consistent with EPA policies. This action is being taken under section 110 and parts C and D of the Act.

  9. Bayesian inference of spectral induced polarization parameters for laboratory complex resistivity measurements of rocks and soils

    NASA Astrophysics Data System (ADS)

    Bérubé, Charles L.; Chouteau, Michel; Shamsipour, Pejman; Enkin, Randolph J.; Olivo, Gema R.

    2017-08-01

    Spectral induced polarization (SIP) measurements are now widely used to infer mineralogical or hydrogeological properties from the low-frequency electrical properties of the subsurface in both mineral exploration and environmental sciences. We present an open-source program that performs fast multi-model inversion of laboratory complex resistivity measurements using Markov-chain Monte Carlo simulation. Using this stochastic method, SIP parameters and their uncertainties may be obtained from the Cole-Cole and Dias models, or from the Debye and Warburg decomposition approaches. The program is tested on synthetic and laboratory data to show that the posterior distribution of a multiple Cole-Cole model is multimodal in particular cases. The Warburg and Debye decomposition approaches yield unique solutions in all cases. It is shown that an adaptive Metropolis algorithm performs faster and is less dependent on the initial parameter values than the Metropolis-Hastings step method when inverting SIP data through the decomposition schemes. There are no advantages in using an adaptive step method for well-defined Cole-Cole inversion. Finally, the influence of measurement noise on the recovered relaxation time distribution is explored. We provide the geophysics community with a open-source platform that can serve as a base for further developments in stochastic SIP data inversion and that may be used to perform parameter analysis with various SIP models.

  10. 75 FR 82535 - Limitation of Approval of Prevention of Significant Deterioration Provisions Concerning...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ...This action is another in a series of steps EPA is taking to implement the Prevention of Significant Deterioration (PSD) program for greenhouse gas (GHG)-emitting sources. EPA is finalizing its proposed rulemaking to narrow its previous approval of State Implementation Plan (SIP) PSD programs in 24 states that apply to GHG-emitting sources. Specifically, EPA is withdrawing its previous approval of those programs to the extent they apply PSD to GHG-emitting sources below the thresholds in the final Tailoring Rule, which EPA promulgated by Federal Register notice dated June 3, 2010. Having narrowed its prior approval, EPA asks that each affected state withdraw from EPA consideration the part of its SIP that is no longer approved. The states for whose SIPs EPA is narrowing approval are: Alabama, California, Colorado, Georgia, Indiana, Iowa, Louisiana, Maine, Maryland, Mississippi, Missouri, New Hampshire, New Mexico, North Carolina, Ohio, Oklahoma, Rhode Island, South Carolina, South Dakota, Tennessee, Utah, Vermont, Virginia, and Wisconsin.

  11. 40 CFR 51.918 - Can any SIP planning requirements be suspended in 8-hour ozone nonattainment areas that have air...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... suspended in 8-hour ozone nonattainment areas that have air quality data that meets the NAAQS? 51.918 Section 51.918 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 8-hour Ozone National Ambient Air Quality Standard § 51.918 Can any SIP planning requirements be...

  12. 40 CFR 51.918 - Can any SIP planning requirements be suspended in 8-hour ozone nonattainment areas that have air...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... suspended in 8-hour ozone nonattainment areas that have air quality data that meets the NAAQS? 51.918 Section 51.918 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 8-hour Ozone National Ambient Air Quality Standard § 51.918 Can any SIP planning requirements be...

  13. 40 CFR 51.918 - Can any SIP planning requirements be suspended in 8-hour ozone nonattainment areas that have air...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... suspended in 8-hour ozone nonattainment areas that have air quality data that meets the NAAQS? 51.918 Section 51.918 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 8-hour Ozone National Ambient Air Quality Standard § 51.918 Can any SIP planning requirements be...

  14. 76 FR 18202 - Applications for New Awards; Asian American and Native American Pacific Islander-Serving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... funds under the AANAPISI program must have an enrollment of undergraduate students that is at least 10... the enrollment of needy students, expenditures, and tie-breaking factors that are based on the SIP... SIP regulations: enrollment of needy students provisions in 34 CFR 607.3 and the low education and...

  15. School Improvement Plans and Student Achievement: Preliminary Evidence from the Quality and Merit Project in Italy

    ERIC Educational Resources Information Center

    Caputo, Andrea; Rastelli, Valentina

    2014-01-01

    This study provides preliminary evidence from an Italian in-service training program addressed to lower secondary school teachers which supports school improvement plans (SIPs). It aims at exploring the association between characteristics/contents of SIPs and student improvement in math achievement. Pre-post standardized tests and text analysis of…

  16. Former Intern: Amy Stull Returns to Her Roots | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer When Amy Stull, a 2000 graduate of Walkersville High School, began working in a laboratory at the National Cancer Institute (NCI) at Frederick, she likely did not know the role NCI would play in her career. Stull started at NCI as a Werner H. Kirsten (WHK) student intern after her junior year of high school, working in a lab as she prepared for a career in chemical engineering. The student intern program pairs rising high school seniors with laboratory scientists to encourage the students to pursue careers in both science and health care fields.

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Easton, C. R.

    The objectives of this program are to establish a heliostat design with the associated manufacturing, assembly, installation and maintenance approaches that will: (1) yield a significant reduction of capital and operating costs; (2) meet performance specifications for large collector subsystems; and (3) can be produced and deployed throughout the southwestern United States. In addition, cost plans and schedules to develop, fabricate, and operate the heliostat are to be developed. This volume presents the collector design, including trade study and test results, and the manufacturing, installation and checkout, and operations and maintenance concepts. Also, a discussion of specification verification and optimizationmore » is included. (WHK)« less

  18. 75 FR 56423 - Approval and Promulgation of Implementation Plans; Texas; Revisions to the New Source Review (NSR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ...EPA is taking final action to disapprove submittals from the State of Texas, through the Texas Commission on Environmental Quality (TCEQ), to revise the Texas Major and Minor NSR SIP. We are disapproving the submittals because they do not meet the 2002 revised Major NSR SIP requirements. We are also disapproving the submittals as not meeting the Major Nonattainment NSR SIP requirements for implementation of the 1997 8-hour ozone national ambient air quality standard (NAAQS) and the 1-hour ozone NAAQS. EPA is disapproving the submitted Standard Permit (SP) for Pollution Control Projects (PCP) because it does not meet the requirements of the CAA for a minor NSR Standard Permit program. Finally, EPA is also disapproving a submitted severable definition of best available control technology (BACT) that is used by TCEQ in its Minor NSR SIP permitting program. EPA is not addressing the submitted revisions concerning the Texas Major PSD NSR SIP, which will be addressed in a separate action. EPA is taking no action on severable provisions that implement section 112(g) of the Act and is restoring a clarification to an earlier action that removed an explanation that a particular provision is not in the SIP because it implements section 112(g) of the Act. EPA is not addressing severable revisions to definitions submitted June 10, 2005, submittal, which will be addressed in a separate action. We are taking no action on a severable provision relating to Emergency and Temporary Orders, which we will address in a separate action. EPA is taking these actions under section 110, part C, and part D, of the Federal Clean Air Act (the Act or CAA).

  19. Laboratory System Improvement Program: First in the Nation— New Hampshire Reassessment

    PubMed Central

    Bean, Christine L.; Cosser, Amanda; Vazquez, Alma

    2013-01-01

    The New Hampshire Public Health Laboratories (NH PHL) conducted an initial Laboratory System Improvement Program (L-SIP) assessment in March 2007 and a reassessment in May 2011. New Hampshire was a pilot state for the initial L-SIP assessment in 2007 and was the first laboratory system in the United States to conduct an L-SIP reassessment. The New Hampshire reassessment was also used as a pilot for revising the assessment tool. The NH PHL performed a high-level comparison benchmarking the work done between the two assessments. This comparison revealed areas of improvement and other areas that needed continued focus to align with model standards of the 10 Essential Public Health Services. This article outlines achievements, improvements, and outcomes made since 2007, as well as participants, activities, plans, resources, and other factors that contributed to the change in scores between assessments. PMID:23997303

  20. Laboratory System Improvement Program: first in the nation--New Hampshire reassessment.

    PubMed

    Power, Jill J; Bean, Christine L; Cosser, Amanda; Vazquez, Alma

    2013-01-01

    The New Hampshire Public Health Laboratories (NH PHL) conducted an initial Laboratory System Improvement Program (L-SIP) assessment in March 2007 and a reassessment in May 2011. New Hampshire was a pilot state for the initial L-SIP assessment in 2007 and was the first laboratory system in the United States to conduct an L-SIP reassessment. The New Hampshire reassessment was also used as a pilot for revising the assessment tool. The NH PHL performed a high-level comparison benchmarking the work done between the two assessments. This comparison revealed areas of improvement and other areas that needed continued focus to align with model standards of the 10 Essential Public Health Services. This article outlines achievements, improvements, and outcomes made since 2007, as well as participants, activities, plans, resources, and other factors that contributed to the change in scores between assessments.

  1. Assessing parents' receptiveness to a vegetable-focussed in-school nutrition intervention.

    PubMed

    Jongenelis, Michelle I; Pettigrew, Simone; Pratt, Iain S; Wright, Shannon; Myers, Gael

    2017-10-01

    Crunch&Sip is an Australian school-based initiative designed to increase the consumption of fruit, vegetables, and water among primary school children. To address the significant deficiencies in children's vegetable intake, the present study aimed to examine the responsiveness of parents (the main providers of food for Crunch&Sip) to a modified version of the program that focuses primarily on vegetable consumption. A total of 329 Western Australian parents completed an online questionnaire examining their support for a vegetable focus for Crunch&Sip and any perceived barriers, motivators, and facilitators. Most (80%) parents were supportive of a shift to a vegetable focus for Crunch&Sip. Belief in the effectiveness of Crunch&Sip at improving children's attitudes towards vegetables and increasing children's vegetable consumption was found to be significantly associated with levels of support. The most commonly nominated motivator was to improve their children's eating habits and the main facilitator was the perceived ability of teachers and peers to influence children's food consumption behaviours. Identified potential barriers included the difficulties associated with providing a variety of vegetables, maintaining freshness, and the preparation time required. The primary suggested strategy to overcome these barriers was for schools to conduct education sessions to provide information about vegetable provision options. The results suggest that parents can be supportive of school-based nutrition programs that specifically encourage the consumption of vegetables but they may require guidance to reduce the identified barriers related to vegetable provision. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Solving groundwater flow problems by conjugate-gradient methods and the strongly implicit procedure

    USGS Publications Warehouse

    Hill, Mary C.

    1990-01-01

    The performance of the preconditioned conjugate-gradient method with three preconditioners is compared with the strongly implicit procedure (SIP) using a scalar computer. The preconditioners considered are the incomplete Cholesky (ICCG) and the modified incomplete Cholesky (MICCG), which require the same computer storage as SIP as programmed for a problem with a symmetric matrix, and a polynomial preconditioner (POLCG), which requires less computer storage than SIP. Although POLCG is usually used on vector computers, it is included here because of its small storage requirements. In this paper, published comparisons of the solvers are evaluated, all four solvers are compared for the first time, and new test cases are presented to provide a more complete basis by which the solvers can be judged for typical groundwater flow problems. Based on nine test cases, the following conclusions are reached: (1) SIP is actually as efficient as ICCG for some of the published, linear, two-dimensional test cases that were reportedly solved much more efficiently by ICCG; (2) SIP is more efficient than other published comparisons would indicate when common convergence criteria are used; and (3) for problems that are three-dimensional, nonlinear, or both, and for which common convergence criteria are used, SIP is often more efficient than ICCG, and is sometimes more efficient than MICCG.

  3. The Effect of the MassHealth Hospital Pay-for-Performance Program on Quality

    PubMed Central

    Ryan, Andrew M; Blustein, Jan

    2011-01-01

    Objective To test the effect of Massachusetts Medicaid's (MassHealth) hospital-based pay-for-performance (P4P) program, implemented in 2008, on quality of care for pneumonia and surgical infection prevention (SIP). Data Hospital Compare process of care quality data from 2004 to 2009 for acute care hospitals in Massachusetts (N = 62) and other states (N = 3,676) and American Hospital Association data on hospital characteristics from 2005. Study Design Panel data models with hospital fixed effects and hospital-specific trends are estimated to test the effect of P4P on composite quality for pneumonia and SIP. This base model is extended to control for the completeness of measure reporting. Further sensitivity checks include estimation with propensity-score matched control hospitals, excluding hospitals in other P4P programs, varying the time period during which the program was assumed to have an effect, and testing the program effect across hospital characteristics. Principal Findings Estimates from our preferred specification, including hospital fixed effects, trends, and the control for measure completeness, indicate small and nonsignificant program effects for pneumonia (−0.67 percentage points, p>.10) and SIP (−0.12 percentage points, p>.10). Sensitivity checks indicate a similar pattern of findings across specifications. Conclusions Despite offering substantial financial incentives, the MassHealth P4P program did not improve quality in the first years of implementation. PMID:21210796

  4. 77 FR 6711 - Approval and Promulgation of Implementation Plans; Arkansas; Infrastructure Requirements for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ...EPA is proposing to partially approve and partially disapprove submittals from the state of Arkansas pursuant to the Clean Air Act (CAA or Act) that address the infrastructure elements specified in the CAA section 110(a)(2), necessary to implement, maintain, and enforce the 1997 8-hour ozone and the 1997 and 2006 fine particulate matter (PM2.5) national ambient air quality standards (NAAQS or standards). We are proposing to find that the current Arkansas State Implementation Plan (SIP) meets the following infrastructure elements for the 1997 8-hour ozone NAAQS and the 1997 and 2006 PM2.5 NAAQS: 110(a)(2)(A), (B), (E), (F), (G), (H), (K), (L), (M), and portions of (C), (D)(ii) and (J). We are proposing to find that the current Arkansas SIP does not meet the infrastructure requirements for the 1997 8-hour ozone NAAQS and the 1997 and 2006 PM2.5 NAAQS at 110(a)(2) for portions of (C), (D)(ii), and (J) because the EPA-approved SIP prevention of significant deterioration (PSD) program does not apply to greenhouse gas (GHG) emitting sources. We also are proposing to find that the current Arkansas SIP does not meet the infrastructure requirements for the 1997 and 2006 PM2.5 NAAQS at 110(a)(2) for portions of (C), (D)(ii), and (J) because Arkansas has not submitted the PSD SIP revision required by EPA's Implementation of the New Source Review (NSR) Program for Particulate Matter Less Than 2.5 Micrometers (73 FR 28321, May 16, 2008). Further, we are proposing to partially approve and partially disapprove the provisions of SIP submissions that emissions from sources in Arkansas do not interfere with measures required in the SIP of any other state under part C of the CAA to prevent significant deterioration of air quality, with regard to the 1997 8-hour ozone NAAQS and the 2006 PM2.5 NAAQS. The partial disapprovals herein are because Arkansas cannot issue permits for GHG emissions and because the State did not submit the required PM2.5 PSD SIP revision. Finally, for purposes of the 1997 8-hour ozone NAAQS, EPA is proposing to approve SIP revisions that modify the Arkansas PSD SIP to include nitrogen oxides (NOX) as an ozone precursor. This action is being taken under section 110 and part C of the Act. Finally, EPA is also proposing to make a correction to the attainment status table in 40 CFR 81.304 to accurately reflect the redesignation date of Crittenden County, Arkansas to attainment for the 1997 8-hour ozone standard.

  5. Mission analysis of photovoltaic solar energy systems. Quarterly progress report, 1 March 1976-31 May 1976

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leonard, S.L.; Munjal, P.K.; Rattin, E.J.

    1976-06-01

    The main emphasis of the activity during the second quarter of this project continued to be on Task 1, Analysis of Near-Term Missions, and on Task 2, Analysis of Major Mid-Term Missions. In addition, considerable progress was also made on Task 6, Comparison of the True Societal Costs of Conventional and Photovoltaic Power Production, and starts were made on Task 3, Review and Updating of the ERDA Technology Implementation Plan, and Task 4, Critical External Issues. As was planned, work on Task 5, Impact of Incentives, was deferred to the second half of the program. Progress is reported. (WHK)

  6. A Four-Session Sleep Intervention Program Improves Sleep for Older Adult Day Health Care Participants: Results of a Randomized Controlled Trial

    PubMed Central

    Song, Yeonsu; Hughes, Jaime; Jouldjian, Stella; Dzierzewski, Joseph M.; Fung, Constance H; Rodriguez Tapia, Juan Carlos; Mitchell, Michael N.; Alessi, Cathy A

    2017-01-01

    Abstract Study Objective To test the effectiveness of a 4-week behavioral Sleep Intervention Program (SIP: sleep compression, modified stimulus control, and sleep hygiene) compared to a 4-week information-only control (IC) among older adults attending a VA Adult Day Health Care (ADHC) program in a double-blind, randomized, clinical trial. Methods Forty-two individuals (mean age: 77 years, 93% male) enrolled in a VA ADHC program were randomized to receive SIP or IC. All completed in-person sleep and health assessments at baseline, post-treatment and 4-months follow-up that included 3 days/nights of wrist actigraphy, the Pittsburgh Sleep Quality Index (PSQI), and the Insomnia Severity Index (ISI). Mixed repeated measures analysis was used to compare sleep outcomes at post-treatment and 4-months follow-up, with baseline values as covariates. Results SIP participants (n = 21) showed significant improvement on actigraphy sleep efficiency (p = .007), number of nighttime awakenings (p = .016), and minutes awake at night (p = .001) at post-treatment, compared to IC participants (n = 21). Benefits were slightly attenuated but remained significant at 4-month follow-up (all p’s < .05). There were no differences in total sleep time between groups. There was significant improvement on PSQI factor 3 (daily disturbances) at 4-month follow-up (p = .016), but no differences were observed between SIP and IC on other PSQI components or ISI scores at post-treatment or 4-month follow-up. Conclusions A short behavioral sleep intervention may have important benefits in improving objectively measured sleep in older adults participating in ADHC. Future studies are needed to study implementation of this intervention into routine clinical care within ADHC. PMID:28482053

  7. 78 FR 26255 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ...EPA is granting direct final approval of a revision to the Texas State Implementation Plan (SIP) concerning the Texas Low Emission Diesel fuel rules. The revisions clarify existing definitions and provisions, revise the approval procedures for alternative diesel fuel formulations, add new registration requirements, and update the rule to reflect the current program status because the rule is now fully implemented. This SIP revision meets statutory requirements.

  8. 78 FR 26301 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ...EPA is proposing approval of a revision to the Texas State Implementation Plan (SIP) concerning the Texas Low Emission Diesel (TxLED) Fuel rules. The revisions clarify existing definitions and provisions, revise the approval procedures for alternative diesel fuel formulations, add new registration requirements, and update the rule to reflect the current program status because the rule is now fully implemented. This SIP revision meets statutory requirements.

  9. Voluntary Mobile Source Programs: Crediting Innovation and Experimentation Brochure

    EPA Pesticide Factsheets

    This EPA document provides guidance on Voluntary Mobile Source Emission Reduction Programs (VMEPs) that could be implemented and credited with emission reductions for State Implementation Plans (SIPs) related purposes.

  10. Fleet Mooring Leg Design Program Documentation. Volume 6. Source Listings: Compound Leg Reverse Solutions and Postprocessor.

    DTIC Science & Technology

    1982-12-01

    0,-C-002S 1JFNC[ASSIF D FIG /2 NL -- W 1.0.8 11111-2 E.M 1 . MtCROCOPY RESOLUT(ON TEST CHART NATIONAL URAU OF $IANoARD - 1963 - A -U4 , *n •A...sel,dtenl ~ss1,dtenl ,ss2, d Iern2,slp0,sO.smin 2 J common /VEOUAL/ ss0 ,dienS 1ssl diel,ss2 ,dien2 sipS saOSsman, & itoid equialence (smtn(IIsamlflJ...1300 12S0 contianus eel-9al dten@- d tenl 1260 contanue dtenl -dt en? 1300 continue n ait-nat* 1 g010 19w0 2000 continue sip-saO-iC ascapa) a told-it 00

  11. 77 FR 11937 - Approval and Promulgation of Air Quality Implementation Plans; State of Alabama; Regional Haze...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ...EPA is proposing a limited approval of a revision to the Alabama state implementation plan (SIP) submitted by the State of Alabama through the Alabama Department of Environmental Management (ADEM), on July 15, 2008, that addresses regional haze for the first implementation period. This revision addresses the requirements of the Clean Air Act (CAA or Act) and EPA's rules that require states to prevent any future and remedy any existing anthropogenic impairment of visibility in mandatory Class I areas (national parks and wilderness areas) caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress towards the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of this SIP revision to implement the regional haze requirements for Alabama on the basis that the revision, as a whole, strengthens the Alabama SIP. Additionally, EPA is proposing to rescind the federal regulations previously approved into the Alabama SIP on November 24, 1987, and to rely on the provisions in Alabama's July 15, 2008, SIP submittal to meet the long-term strategy (LTS) requirements for reasonably attributable visibility impairment (RAVI). EPA has previously proposed a limited disapproval of the Alabama regional haze SIP because of deficiencies in the State's regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District of Columbia Circuit (DC Circuit) to EPA of the Clean Air Interstate Rule (CAIR). Consequently, EPA is not proposing to take action in this rulemaking to address the State's reliance on CAIR to meet certain regional haze requirements.

  12. WHK Student Interns Named Top Scholars in Regeneron Science Talent Search | Poster

    Cancer.gov

    Two Werner H. Kirsten Student Interns were recently named Top Scholars in the 2017 Regeneron Science Talent Search, the nation’s most prestigious science and math competition for high school students.

  13. Chemotherapy appointment scheduling under uncertainty using mean-risk stochastic integer programming.

    PubMed

    Alvarado, Michelle; Ntaimo, Lewis

    2018-03-01

    Oncology clinics are often burdened with scheduling large volumes of cancer patients for chemotherapy treatments under limited resources such as the number of nurses and chairs. These cancer patients require a series of appointments over several weeks or months and the timing of these appointments is critical to the treatment's effectiveness. Additionally, the appointment duration, the acuity levels of each appointment, and the availability of clinic nurses are uncertain. The timing constraints, stochastic parameters, rising treatment costs, and increased demand of outpatient oncology clinic services motivate the need for efficient appointment schedules and clinic operations. In this paper, we develop three mean-risk stochastic integer programming (SIP) models, referred to as SIP-CHEMO, for the problem of scheduling individual chemotherapy patient appointments and resources. These mean-risk models are presented and an algorithm is devised to improve computational speed. Computational results were conducted using a simulation model and results indicate that the risk-averse SIP-CHEMO model with the expected excess mean-risk measure can decrease patient waiting times and nurse overtime when compared to deterministic scheduling algorithms by 42 % and 27 %, respectively.

  14. Consumption with Large Sip Sizes Increases Food Intake and Leads to Underestimation of the Amount Consumed

    PubMed Central

    Bolhuis, Dieuwerke P.; Lakemond, Catriona M. M.; de Wijk, Rene A.; Luning, Pieternel A.; de Graaf, Cees

    2013-01-01

    Background A number of studies have shown that bite and sip sizes influence the amount of food intake. Consuming with small sips instead of large sips means relatively more sips for the same amount of food to be consumed; people may believe that intake is higher which leads to faster satiation. This effect may be disturbed when people are distracted. Objective The objective of the study is to assess the effects of sip size in a focused state and a distracted state on ad libitum intake and on the estimated amount consumed. Design In this 3×2 cross-over design, 53 healthy subjects consumed ad libitum soup with small sips (5 g, 60 g/min), large sips (15 g, 60 g/min), and free sips (where sip size was determined by subjects themselves), in both a distracted and focused state. Sips were administered via a pump. There were no visual cues toward consumption. Subjects then estimated how much they had consumed by filling soup in soup bowls. Results Intake in the small-sip condition was ∼30% lower than in both the large-sip and free-sip conditions (P<0.001). In addition, subjects underestimated how much they had consumed in the large-sip and free-sip conditions (P<0.03). Distraction led to a general increase in food intake (P = 0.003), independent of sip size. Distraction did not influence sip size or estimations. Conclusions Consumption with large sips led to higher food intake, as expected. Large sips, that were either fixed or chosen by subjects themselves led to underestimations of the amount consumed. This may be a risk factor for over-consumption. Reducing sip or bite sizes may successfully lower food intake, even in a distracted state. PMID:23372657

  15. A Four-Session Sleep Intervention Program Improves Sleep for Older Adult Day Health Care Participants: Results of a Randomized Controlled Trial.

    PubMed

    Martin, Jennifer L; Song, Yeonsu; Hughes, Jaime; Jouldjian, Stella; Dzierzewski, Joseph M; Fung, Constance H; Rodriguez Tapia, Juan Carlos; Mitchell, Michael N; Alessi, Cathy A

    2017-08-01

    To test the effectiveness of a 4-week behavioral Sleep Intervention Program (SIP: sleep compression, modified stimulus control, and sleep hygiene) compared to a 4-week information-only control (IC) among older adults attending a VA Adult Day Health Care (ADHC) program in a double-blind, randomized, clinical trial. Forty-two individuals (mean age: 77 years, 93% male) enrolled in a VA ADHC program were randomized to receive SIP or IC. All completed in-person sleep and health assessments at baseline, post-treatment and 4-months follow-up that included 3 days/nights of wrist actigraphy, the Pittsburgh Sleep Quality Index (PSQI), and the Insomnia Severity Index (ISI). Mixed repeated measures analysis was used to compare sleep outcomes at post-treatment and 4-months follow-up, with baseline values as covariates. SIP participants (n = 21) showed significant improvement on actigraphy sleep efficiency (p = .007), number of nighttime awakenings (p = .016), and minutes awake at night (p = .001) at post-treatment, compared to IC participants (n = 21). Benefits were slightly attenuated but remained significant at 4-month follow-up (all p's < .05). There were no differences in total sleep time between groups. There was significant improvement on PSQI factor 3 (daily disturbances) at 4-month follow-up (p = .016), but no differences were observed between SIP and IC on other PSQI components or ISI scores at post-treatment or 4-month follow-up. A short behavioral sleep intervention may have important benefits in improving objectively measured sleep in older adults participating in ADHC. Future studies are needed to study implementation of this intervention into routine clinical care within ADHC. Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  16. Staff Development in the Implementation of a Schoolwide Writing Program.

    ERIC Educational Resources Information Center

    Knudson, Ruth

    A case study examined the implementation of a schoolwide writing program established in a California middle school through a district sponsored school improvement program (SIP). Conducted at an urban sprawl southern California school of approximately 900 students in grades seven and eight, the program was directed and implemented by the English…

  17. SUMMARY OF EPA'S PARTICULATE MATTER SUPERSITES PROGRAM: RESULTS THAT CAN BE USED TO PREPARE AND EVALUATE STATE IMPLEMENTATION PLANS (SIPS)

    EPA Science Inventory

    In 1999, the United States Environmental Protection Agency (EPA) initiated a major air quality program referred to as the Particulate Matter (PM) Supersites Program. The PM Supersites Program is a multi-year, $27 million air quality program consisting of eight (8) regional air q...

  18. Proceedings of the 3rd national passive solar conference. Volume 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, H.; Riordan, M.; Richards, D.

    1979-01-01

    Separate abstracts were prepared for 149 of the 163 papers presented. The remaining 14 papers were previously included in the data base and can be found in the report number index under report number CONF-790118--. (WHK)

  19. 76 FR 78194 - Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of Kentucky; Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ...EPA is proposing a limited approval and a limited disapproval of two revisions to the Kentucky State Implementation Plan (SIP) submitted by the Commonwealth of Kentucky through the Kentucky Energy and Environment Cabinet, Division of Air Quality (KYDAQ), on June 25, 2008, and May 28, 2010, that address regional haze for the first implementation period. These revisions address the requirements of the Clean Air Act (CAA or Act) and EPA's rules that require states to prevent any future and remedy any existing anthropogenic impairment of visibility in mandatory Class I areas (national parks and wilderness areas) caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of these SIP revisions to implement the regional haze requirements for Kentucky on the basis that the revisions, as a whole, strengthen the Kentucky SIP. Also in this action, EPA is proposing a limited disapproval of these same SIP revisions because of the deficiencies in the Commonwealth's regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District of Columbia Circuit (DC Circuit) to EPA of the Clean Air Interstate Rule (CAIR).

  20. 77 FR 73316 - Approval of Air Quality Implementation Plans; California; Eastern Kern, Imperial, Placer, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ... adopt and implement a SIP- approved Prevention of Significant Deterioration (PSD) permit program. We are...--Prevention of Significant Deterioration (PSD) Permit Program, PCAPCD Rule 518--Prevention of Significant Deterioration (PSD) Permit Program, and YSAQMD Rule 3.24-- Prevention of Significant Deterioration. The approval...

  1. Research and development studies for MHD/coal power flow train components. Technical progress report, 1 September 1979-31 August 1980

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bloom, M. H.

    1980-01-01

    The aim of this program is to contribute to certain facets of the development of the MHD/coal power system, and particularly the CDIF of DOE with regard to its flow train. Consideration is given specifically to the electrical power take-off, the diagnostic and instrumentation systems, the combustor and MHD channel technology, and electrode alternatives. Within the constraints of the program, high priorities were assigned to the problems of power take-off and the related characteristics of the MHD channel, and to the establishment of a non-intrusive, laser-based diagnostic system. The next priority was given to the combustor modeling and to amore » significantly improved analysis of particle combustion. Separate abstracts were prepared for nine of the ten papers included. One paper was previously included in the data base. (WHK)« less

  2. OVERVIEW AND STATUS OF THE PM SUPERSITES PROGRAM

    EPA Science Inventory

    The PM Supersites program was first conceived as a set of special studies extending beyond the national regulatory networks for particulate matter (PM) to elucidate source-receptor relationships and atmospheric processes in support of State implementation plans (SIP's). The pr...

  3. 76 FR 28944 - Revisions to the California State Implementation Plan, Placer County Air Pollution Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ...EPA is proposing a limited approval and limited disapproval of permitting rules submitted for the Placer County Air Pollution Control District (PCAPCD) and Feather River Air Quality Management District (FRAQMD) portion of the California State Implementation Plan (SIP). The districts are required under Part D of title I of the Clean Air Act (CAA) to adopt and implement a SIP-approved New Source Review (NSR) permit program. These rules update and revise the District's NSR permitting program for new and modified sources of air pollution. If EPA finalizes the limited approval and limited disapproval action, as proposed, then a sanctions clock would be triggered. We are taking comments on this proposal and plan to follow with a final action.

  4. Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 1. Executive summary. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1979-06-01

    The conceptual design of an advanced central receiver power system using liquid sodium as a heat transport medium has been completed by a team consisting of the Energy Systems Group (prime contractor), McDonnell Douglas, Stearns-Roger, The University of Houston, and Salt River Project. The purpose of this study was to determine the technical and economic advantages of this concept for commercial-scale power plants. This final report covers all tasks of the project. These tasks were as follows: (1) review and analysis of preliminary specification; (2) parametric analysis; (3) select commercial configuration; (4) commercial plant conceptual design; (5) assessment of commercialmore » plant; (6) advanced central receiver power system development plan; (7) program plan; (8) reports and data; (9) program management; and (10) safety analysis. A programmatic overview of the accomplishments of this program is given. The 100-MW conceptual commercial plant, the 281-MW optimum plant, and the 10-MW pilot plant are described. (WHK)« less

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The final design, performance analysis, and economic analysis of a solar hot water system for curing concrete blocks at the new Rotoclave block fabricating plant being built by the York Building Products Co. Inc. at Harrisburg, Pa. are presented. The system will use AAI Corporation's 24/1 concentrating collectors. (WHK)

  6. Nuclear Physics Laboratory 1979 annual report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adelberger, E.G.

    1979-07-01

    Research progress is reported in the following areas: astrophysics and cosmology, fundamental symmetries, nuclear structure, radiative capture, medium energy physics, heavy ion reactions, research by users and visitors, accelerator and ion source development, instrumentation and experimental techniques, and computers and computing. Publications are listed. (WHK)

  7. 77 FR 12651 - Approval of Air Quality Implementation Plans; California; San Joaquin Valley; Attainment Plan for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... standards for which EPA has issued the waiver. CARB has as long a history of enforcement of vehicle/engine... program. The history and rigor of CARB's enforcement program lends assurance to California SIP revisions...

  8. Air Permitting Delegations in EPA's New England Region

    EPA Pesticide Factsheets

    All Region 1 states have EPA-approved Title V operating permit programs. In addition, all Region 1 states have either SIP-approved NSR/PSD permitting programs or the state has been delegated as the permitting authority for NSR/PSD permits by EPA.

  9. 76 FR 77982 - Applications for Eligibility Designation; Programs Under Parts A and F of Title III of the Higher...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... Title III of the Higher Education Act of 1965, as Amended (HEA), and Programs Under Title V of the HEA...: Programs authorized under Part A, Title III of the HEA: Strengthening Institutions Program (Part A SIP... AANAPISI). Programs authorized under Part F, Title III of the HEA: Hispanic- Serving Institutions Stem and...

  10. 77 FR 67805 - Applications for Eligibility Designation; Programs Under Parts A and F of Title III of the Higher...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... Title III of the Higher Education Act of 1965, as Amended (HEA), and Programs Under Title V of the HEA...: Programs authorized under Part A, Title III of the HEA: Strengthening Institutions Program (Part A SIP...). Programs authorized under Part F, Title III of the HEA: Hispanic- Serving Institutions STEM and...

  11. Environmental Info for South Dakota

    EPA Pesticide Factsheets

    This page contains information about air and water in South Dakota, including state implementation programs (SIPs), air permitting, underground injection control (UIC) and National Pollution Discharge Elimination System (NPDES).

  12. 78 FR 37741 - Approval and Promulgation of Implementation Plans; California; South Coast; Contingency Measures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    .... Id. \\7\\ Consistent with EPA's definition of ``design value'' in 40 CFR 58.1, we use the term ``design... evaluations below. Carl Moyer Memorial Air Quality Standards Attainment Program The Contingency Measures SIP identifies a portion of the Carl Moyer Memorial Air Quality Standards Attainment Program (Carl Moyer Program...

  13. WHK Interns Dominate Student Jeopardy Tournament | Poster

    Cancer.gov

    A field of study that derives its name from the Latin root for “knowledge”—student interns had a shot at that clue for 200 points in the 10th annual Student Science Jeopardy Tournament, but their minds went blank. Answer: What is Science?

  14. Use of solar energy for mobile field domitory space and hot water heating

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Turulov, V.A.; Kaem, Yu.Z.

    1978-01-01

    The solar space and water heating system for a mobile vehicle which serves as a field dormitory for five people is briefly described. The system utilizes a liquid type thermosyphon solar collector and a hot water storage tank. (WHK)

  15. 76 FR 81727 - Approval and Promulgation of Implementation Plans; Oklahoma; Federal Implementation Plan for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ...EPA is partially approving and partially disapproving a revision to the Oklahoma State Implementation Plan (SIP) submitted by the State of Oklahoma through the Oklahoma Department of Environmental Quality on February 19, 2010, intended to address the regional haze requirements of the Clean Air Act (CAA). In addition, EPA is partially approving and partially disapproving a portion of a revision to the Oklahoma SIP submitted by the State of Oklahoma on May 10, 2007 and supplemented on December 10, 2007 to address the requirements of CAA section 110(a)(2)(D)(i)(II) as it applies to visibility for the 1997 8- hour ozone and 1997 fine particulate matter National Ambient Air Quality Standards. This CAA requirement is intended to prevent emissions from one state from interfering with the visibility programs in another state. EPA is approving certain core elements of the SIP including Oklahoma's: determination of baseline and natural visibility conditions; coordinating regional haze and reasonably attributable visibility impairment; monitoring strategy and other implementation requirements; coordination with states and Federal Land Managers; and a number of NOX, SO2, and PM BART determinations. EPA is finding that Oklahoma's regional haze SIP did not address the sulfur dioxide Best Available Retrofit Technology requirements for six units in Oklahoma in accordance with the Regional Haze requirements, or the requirement to prevent interference with other states' visibility programs. EPA is promulgating a Federal Implementation Plan to address these deficiencies by requiring emissions to be reduced at these six units. This action is being taken under section 110 and part C of the CAA.

  16. 76 FR 11082 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Oxides of Nitrogen Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Promulgation of Air Quality Implementation Plans; Ohio; Oxides of Nitrogen Budget Trading Program; Technical... concerning 240 allowances under the Nitrogen Oxides Budget Trading Program added to the SIP by EPA rulemaking... EPA approve rule revisions [[Page 11083

  17. 77 FR 11958 - Approval and Promulgation of Air Quality Implementation Plans; State of Missouri; Regional Haze...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ...EPA is proposing a limited approval of a revision to the Missouri State Implementation Plan (SIP) submitted by the State of Missouri through the Missouri Department of Natural Resources (MDNR) on August 5, 2009, and supplemental information submitted on January 30, 2012, that addresses regional haze for the first implementation period. This revision addresses the requirements of the Clean Air Act (CAA or ``Act'') and EPA's rules that require states to prevent any future and remedy any existing anthropogenic impairment of visibility in mandatory Class I areas caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of this SIP revision to implement the regional haze requirements for Missouri on the basis that the revision, as a whole, strengthens the Missouri SIP. In a separate action EPA has previously proposed a limited disapproval of the Missouri regional haze SIP because of deficiencies in the State's regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District Court of Columbia (DC Circuit) to the EPA of the Clean Air Interstate Rule (CAIR). See 76 FR 82219. Therefore, we are not taking action in this notice to address the State's reliance on CAIR to meet certain regional haze requirements.

  18. 77 FR 11858 - Approval and Promulgation of Air Quality Implementation Plans; State of North Carolina; Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ...EPA is proposing a limited approval of a revision to the North Carolina state implementation plan (SIP) submitted by the State of North Carolina through the North Carolina Department of Environment and Natural Resources, Division of Air Quality (NCDAQ), on December 17, 2007, that addresses regional haze for the first implementation period. This revision addresses the requirements of the Clean Air Act (CAA) and EPA's rules that require states to prevent any future and remedy any existing anthropogenic impairment of visibility in mandatory Class I areas (national parks and wilderness areas) caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of this SIP revision to implement the regional haze requirements for North Carolina on the basis that the revision, as a whole, strengthens the North Carolina SIP. In a separate action, EPA has proposed a limited disapproval of the North Carolina regional haze SIP because of deficiencies in the State's regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District of Columbia Circuit (DC Circuit) to EPA of the Clean Air Interstate Rule (CAIR). Consequently, EPA is not proposing to take action in this rulemaking to address the State's reliance on CAIR to meet certain regional haze requirements.

  19. A chemogenomic analysis of the human proteome: application to enzyme families.

    PubMed

    Bernasconi, Paul; Chen, Min; Galasinski, Scott; Popa-Burke, Ioana; Bobasheva, Anna; Coudurier, Louis; Birkos, Steve; Hallam, Rhonda; Janzen, William P

    2007-10-01

    Sequence-based phylogenies (SBP) are well-established tools for describing relationships between proteins. They have been used extensively to predict the behavior and sensitivity toward inhibitors of enzymes within a family. The utility of this approach diminishes when comparing proteins with little sequence homology. Even within an enzyme family, SBPs must be complemented by an orthogonal method that is independent of sequence to better predict enzymatic behavior. A chemogenomic approach is demonstrated here that uses the inhibition profile of a 130,000 diverse molecule library to uncover relationships within a set of enzymes. The profile is used to construct a semimetric additive distance matrix. This matrix, in turn, defines a sequence-independent phylogeny (SIP). The method was applied to 97 enzymes (kinases, proteases, and phosphatases). SIP does not use structural information from the molecules used for establishing the profile, thus providing a more heuristic method than the current approaches, which require knowledge of the specific inhibitor's structure. Within enzyme families, SIP shows a good overall correlation with SBP. More interestingly, SIP uncovers distances within families that are not recognizable by sequence-based methods. In addition, SIP allows the determination of distance between enzymes with no sequence homology, thus uncovering novel relationships not predicted by SBP. This chemogenomic approach, used in conjunction with SBP, should prove to be a powerful tool for choosing target combinations for drug discovery programs as well as for guiding the selection of profiling and liability targets.

  20. Psychometric evaluation of the Social Interaction Phobia Scale.

    PubMed

    Reilly, Alison R; Carleton, R Nicholas; Weeks, Justin W

    2012-01-01

    The present study evaluated the psychometric properties of a novel measure of social anxiety symptoms, the Social Interaction Phobia Scale (SIPS), as a stand-alone item set, using an undergraduate sample (N=512). The 14-item SIPS has three subscales assessing Social Interaction Anxiety, Fear of Overt Evaluation, and Fear of Attracting Attention. Confirmatory factor analyses replicated the three-factor structure for the SIPS originally reported by Carleton et al. All SIPS scores demonstrated good internal consistency. The convergent validity of the SIPS was supported by strong and positive correlations between all SIPS scores and measures of social anxiety and fear of evaluation; the finding that the relationships between all SIPS scores and a social anxiety measure were stronger than relationships between all SIPS scores and measures of other constructs supported the discriminant validity of the SIPS. Results suggest that the SIPS possesses excellent psychometric properties.

  1. Advances in recurrence and malignant transformation of sinonasal inverted papillomas

    PubMed Central

    Sun, Qingjia; An, Lifeng; Zheng, Jun; Zhu, Dongdong

    2017-01-01

    Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. SIP is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to SIP recurrence. A growing body of evidence suggests that molecular alteration in SIP, including human papilloma virus infections, single nucleotide polymorphisms of key genes, deregulation of signaling pathways and immunological changes, may lead to SIP occurrence and malignant transformation. However, the extent to which these molecular mechanisms contribute to SIP pathology and transformation remains unclear due to limited research. Further studies are warranted to elucidate the primary dependent factors that contribute to SIP etiology. The present article reviewed risk factors of progression and recurrence of SIP, including outdoor and industrial occupational exposure, smoking, septal deviation, SIP location, recurrent cases, stage of SIP-associated squamous cell carcinoma and choice of surgical method. PMID:28599459

  2. California State Implementation Plan; Butte County Air Quality Management District; New Source Review (NSR) Permitting Program

    EPA Pesticide Factsheets

    EPA is proposing to approve a revision to the Butte County Air Quality Management District (BCAQMD) portion of the California SIP concerning the District's New Source Review (NSR) permitting program for new and modified sources of air pollution.

  3. Praises & Nudges: A Case of District-Wide Change.

    ERIC Educational Resources Information Center

    Doyle, Richard; And Others

    This paper describes the processes and outcomes experienced by the Marshalltown Community School District (Iowa) as it implemented a shared decision-making, school-improvement program. A district Shared Decision Making (SDM) Team and School Improvement Program (SIP) teams were trained to facilitate greater staff participation in the…

  4. EPA Webinar on the Energy Efficiency/Renewable Energy Manual

    EPA Pesticide Factsheets

    existing EPA EE/RE SIP guidance, policies and programs in the jurisdiction, electric energy system, roles and responsibilities of key state energy-related organizations, emission benefits, screening analysis

  5. 40 CFR 93.165 - Early emission reduction credit programs at Federal facilities and installation subject to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Early emission reduction credit... Federal Actions to State or Federal Implementation Plans § 93.165 Early emission reduction credit programs... the SIP or TIP in that area, create an early emissions reductions credit program. The Federal agency...

  6. 40 CFR 93.165 - Early emission reduction credit programs at Federal facilities and installation subject to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Early emission reduction credit... Federal Actions to State or Federal Implementation Plans § 93.165 Early emission reduction credit programs... the SIP or TIP in that area, create an early emissions reductions credit program. The Federal agency...

  7. Biomass Burning Emissions – The Importance of Reducing Uncertainties for Improved Regulatory Decision; an EPA Perspective

    EPA Science Inventory

    Biomass burning emissions from wildland and prescribed fires can have far reaching impacts in several of EPA’s regulatory programs under the Clean Air Act, ultimately affecting decisions on actions taken under State Implementation Plans (SIPs), and programs such as Visibility and...

  8. 40 CFR 52.241 - Interim approval of enhanced inspection and maintenance program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California... Act (Pub. L. 104-59), the California SIP is approved as meeting the provisions of section 182(c)(3.... (a) [Reserved] (b) Approval. On June 5, 2009, the California Air Resources Board submitted a revision...

  9. WHK Interns Win Big at Frederick County Science Fair | Poster

    Cancer.gov

    Three Werner H. Kirsten student interns claimed awards at the 35th Annual Frederick County Science and Engineering Fair—and got a shot at the national competition—for imaginative projects that reached out to the rings of Saturn and down to the details of advanced cancer diagnostics.

  10. Energy Efficiency/Renewable Energy Programs in State Implementation Plans - Guidance Documents

    EPA Pesticide Factsheets

    final document that provides guidance to States and local areas on quantifying and including emission reductions from energy efficiency and renewable energy measures in State Implementation Plans (SIPS).

  11. Prevalence and Correlates of Sipping Alcohol in a Prospective Middle School Sample

    PubMed Central

    Jackson, Kristina M.; Colby, Suzanne M.; Barnett, Nancy P.; Abar, Caitlin C.

    2015-01-01

    Research documents an association between early use of alcohol and adverse outcomes. Most studies on drinking initiation exclude sipping or confound sips with consumption of a full drink. Yet, even a few sips of alcohol can constitute a meaningful experience for naïve drinkers. Prior research with this project indicated that sipping prior to middle school predicted subsequent adverse outcomes (at high-school entry), even controlling for child externalizing and sensation seeking and parent alcohol use. The present study extends our prior work by examining the correlates of early sipping and sipping onset. The sample was comprised of 1,023 6th, 7th, and 8th graders (52% female; 24% non-White, 12% Hispanic). Participants completed web-based surveys on five occasions over the course of two years. The prevalence of sipping at Wave 1 was 37%, with 29% of never-sippers initiating sipping within two years. Sipping was associated with stronger alcohol-related cognitions and low school engagement as well as contextual influences in the peer, sibling, and parent domains. Sipping onset among never-sippers was prospectively predicted by sensation seeking and problem behavior as well as parental and sibling influences. Importantly, mere availability of alcohol was a strong correlate both concurrently and prospectively. Further analyses demonstrated that youth who sipped alcohol with parental permission had a lower profile of risk and healthier relationships with parents as compared to youth who reported unsanctioned sipping. Findings point to the importance of considering fine-grained early drinking behavior and call for further attention to sipping in research on initiation of alcohol use. PMID:25938631

  12. Friendship quality and social information processing in clinically anxious children.

    PubMed

    Baker, J R; Hudson, J L

    2014-02-01

    The association between perceived friendship quality (FQ) and social information processing (SIP) was examined in three groups of children and their close friends aged 7-12 years: 16 anxiety disordered children with social phobia (SP); 12 anxiety disordered children without SP (No-SP); and 32 nonclinical children. Positive and negative FQ positively associated with target children's positive and negative responding on a vignette measure of SIP. SP children reported lower positive SIP than No-SP but not nonclinical children; and this was the only group difference in SIP. Target children and their friends were similar in negative but not positive SIP. Following discussion about the vignette with a close friend, all target children increased in positive SIP; negative SIP did not change. Lower FQ and a more socially anxious friend predicted higher negative target child SIP postdiscussion. Close friendships play an important role in the SIP of both clinical and nonclinical children.

  13. 77 FR 76173 - Approval and Promulgation of Implementation Plans; State of Washington; Regional Haze State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ...EPA is proposing to partially approve and partially disapprove a Washington Regional Haze Implementation Plan (SIP) submitted by the State of Washington on December 22, 2010, that addresses regional haze for the first implementation period. This plan was submitted to meet the requirements of Clean Air Act (CAA) sections 169A and 169B that require states to prevent any future and remedy any existing man-made impairment of visibility in mandatory Class I areas. EPA is proposing to: (1) Approve portions of this SIP submittal as meeting most of the requirements of the regional haze program, (2) propose a limited approval and limited disapproval of the SO2 Best Available Retrofit Technology (BART) determination for Intalco Aluminum Corp. (Intalco) potline operation and propose a federal ``Better than BART'' alternative, and (3) propose to disapprove the NOx BART determination for five BART emission units at the Tesoro Refining and Marketing refinery (Tesoro) and propose a federal Better than BART alternative. This combined rule package of proposed SIP approved elements and proposed federal elements will meet the requirements of CAA sections 169A and 169B. On August 20, 2012, EPA approved those provisions of the Washington SIP addressing the BART determination for TransAlta Centralia Generation L.L.C. coal fired power plant (TransAlta).

  14. Silica-Induced Protein (Sip) in Thermophilic Bacterium Thermus thermophilus Responds to Low Iron Availability

    PubMed Central

    Fujino, Yasuhiro; Nagayoshi, Yuko; Iwase, Makoto; Yokoyama, Takushi; Ohshima, Toshihisa

    2016-01-01

    ABSTRACT Thermus thermophilus HB8 expresses silica-induced protein (Sip) when cultured in medium containing supersaturated silicic acids. Using genomic information, Sip was identified as a Fe3+-binding ABC transporter. Detection of a 1-kb hybridized band in Northern analysis revealed that sip transcription is monocistronic and that sip has its own terminator and promoter. The sequence of the sip promoter showed homology with that of the σA-dependent promoter, which is known as a housekeeping promoter in HB8. Considering that sip is transcribed when supersaturated silicic acids are added, the existence of a repressor is presumed. DNA microarray analysis suggested that supersaturated silicic acids and iron deficiency affect Thermus cells similarly, and enhanced sip transcription was detected under both conditions. This suggested that sip transcription was initiated by iron deficiency and that the ferric uptake regulator (Fur) controlled the transcription. Three Fur gene homologues (TTHA0255, TTHA0344, and TTHA1292) have been annotated in the HB8 genome, and electrophoretic mobility shift assays revealed that the TTHA0344 product interacts with the sip promoter region. In medium containing supersaturated silicic acids, free Fe3+ levels were decreased due to Fe3+ immobilization on colloidal silica. This suggests that, because Fe3+ ions are captured by colloidal silica in geothermal water, Thermus cells are continuously exposed to the risk of iron deficiency. Considering that Sip is involved in iron acquisition, Sip production may be a strategy to survive under conditions of low iron availability in geothermal water. IMPORTANCE The thermophilic bacterium Thermus thermophilus HB8 produces silica-induced protein (Sip) in the presence of supersaturated silicic acids. Sip has homology with iron-binding ABC transporter; however, the mechanism by which Sip expression is induced by silicic acids remains unexplained. We demonstrate that Sip captures iron and its transcription is regulated by the repressor ferric uptake regulator (Fur). This implies that Sip is expressed with iron deficiency. In addition, it is suggested that negatively charged colloidal silica in supersaturated solution absorbs Fe3+ ions and decreases iron availability. Considering that geothermal water contains ample silicic acids, it is suggested that thermophilic bacteria are always facing iron starvation. Sip production may be a strategy for surviving under conditions of low iron availability in geothermal water. PMID:26994077

  15. 77 FR 3691 - Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of Virginia; Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ...EPA is proposing a limited approval and a limited disapproval of six revisions to the Virginia State Implementation Plan (SIP) submitted by the Commonwealth of Virginia, through the Department of Environmental Quality (VADEQ), that address regional haze for the first implementation period. These revisions address the requirements of the Clean Air Act (CAA or Act) and EPA's rules that require states to prevent any future and remedy any existing anthropogenic impairment of visibility in mandatory Class I areas (national parks and wilderness areas) caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of these SIP revisions to implement the regional haze requirements for Virginia on the basis that the revisions, as a whole, strengthen the Virginia SIP. Also in this action, EPA is proposing a limited disapproval of these same SIP revisions because of the deficiencies in the Commonwealth's regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District of Columbia (DC Circuit) to EPA of the Clean Air Interstate Rule (CAIR). EPA is also proposing to approve this revision as meeting the infrastructure requirements relating to visibility protection for the 1997 8-Hour Ozone National Ambient Air Quality Standard (NAAQS) and the 1997 and 2006 fine particulate matter (PM2.5) NAAQS.

  16. Use of mathematical decomposition to optimize investments in gas production and distribution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dougherty, E.L.; Lombardino, E.; Hutchinson, P.

    1986-01-01

    This paper presents an analytical approach based upon the decomposition method of mathematical programming for determining the optimal investment sequence in each year of a planning horizon for a group of reservoirs that produce gas and gas liquids through a trunk-line network and a gas processing plant. The paper describes the development of the simulation and investment planning system (SIPS) to perform the required calculations. Net present value (NPV) is maximized with the requirement that the incremental present value ratio (PWPI) of any investment in any reservoir be greater than a specified minimum value. A unique feature is a gasmore » reservoir simulation model that aids SIPS in evaluating field development investments. The optimal solution supplies specified dry gas offtake requirements through time until the remaining reserves are insufficient to meet requirements economically. The sales value of recovered liquids contributes significantly to NPV, while the required spare gas-producing capacity reduces NPV. Sips was used successfully for 4 years to generate annual investment plans and operating budgets, and to perform many special studies for a producing complex containing over 50 reservoirs. This experience is reviewed. In considering this large problem, SIPS converges to the optimal solution in 10 to 20 iterations. The primary factor that determines this number is how good the starting guess is. Although sips can generate a starting guess, beginning with a previous optimal solution ordinarily results in faster convergence. Computing time increases in proportion to the number of reservoirs because more than 90% of computing time is spent solving the, reservoir, subproblems.« less

  17. 75 FR 55978 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Revisions to the New Source...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... Implementation Plan (SIP); Prevention of Significant Deterioration (PSD) AGENCY: Environmental Protection Agency... Texas PSD State Implementation Plan (SIP). EPA is approving a SIP revision submitted February 1, 2006... Texas PSD SIP; it merely approves reorganization and renumbering of the Texas PSD SIP rules. Further...

  18. 46 CFR 8.570 - Interim approval of prototype SIP company or vessel plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Interim approval of prototype SIP company or vessel... of prototype SIP company or vessel plans. (a) A company operating under an approved prototype SIP... continue operating under the plans while revisions are developed to bring the prototype SIP company or...

  19. The Spectral Image Processing System (SIPS): Software for integrated analysis of AVIRIS data

    NASA Technical Reports Server (NTRS)

    Kruse, F. A.; Lefkoff, A. B.; Boardman, J. W.; Heidebrecht, K. B.; Shapiro, A. T.; Barloon, P. J.; Goetz, A. F. H.

    1992-01-01

    The Spectral Image Processing System (SIPS) is a software package developed by the Center for the Study of Earth from Space (CSES) at the University of Colorado, Boulder, in response to a perceived need to provide integrated tools for analysis of imaging spectrometer data both spectrally and spatially. SIPS was specifically designed to deal with data from the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) and the High Resolution Imaging Spectrometer (HIRIS), but was tested with other datasets including the Geophysical and Environmental Research Imaging Spectrometer (GERIS), GEOSCAN images, and Landsat TM. SIPS was developed using the 'Interactive Data Language' (IDL). It takes advantage of high speed disk access and fast processors running under the UNIX operating system to provide rapid analysis of entire imaging spectrometer datasets. SIPS allows analysis of single or multiple imaging spectrometer data segments at full spatial and spectral resolution. It also allows visualization and interactive analysis of image cubes derived from quantitative analysis procedures such as absorption band characterization and spectral unmixing. SIPS consists of three modules: SIPS Utilities, SIPS_View, and SIPS Analysis. SIPS version 1.1 is described below.

  20. BISIP I: A program for Bayesian inference of spectral induced polarization parameters, and application to mineral exploration at the Canadian Malartic gold deposit, Québec, CA

    NASA Astrophysics Data System (ADS)

    Lafrenière-Bérubé, Charles; Chouteau, Michel; Shamsipour, Pejman; Olivo, Gema R.

    2016-04-01

    Spectral induced polarization (SIP) parameters can be extracted from field or laboratory complex resistivity measurements, and even airborne or ground frequency domain electromagnetic data. With the growing interest in application of complex resistivity measurements to environmental and mineral exploration problems, there is a need for accurate and easy-to-use inversion tools to estimate SIP parameters. These parameters, which often include chargeability and relaxation time may then be studied and related to other rock attributes such as porosity or metallic grain content, in the case of mineral exploration. We present an open source program, available both as a standalone application or Python module, to estimate SIP parameters using Markov-chain Monte Carlo (MCMC) sampling. The Python language is a high level, open source language that is now widely used in scientific computing. Our program allows the user to choose between the more common Cole-Cole (Pelton), Dias, or Debye decomposition models. Simple circuits composed of resistances and constant phase elements may also be used to represent SIP data. Initial guesses are required when using more classic inversion techniques such as the least-squares formulation, and wrong estimates are often the cause of bad curve fitting. In stochastic optimization using MCMC, the effect of the starting values disappears as the simulation proceeds. Our program is then optimized to do batch inversion over large data sets with as little user-interaction as possible. Additionally, the Bayesian formulation allows the user to do quality control by fully propagating the measurement errors in the inversion process, providing an estimation of the SIP parameters uncertainty. This information is valuable when trying to relate chargeability or relaxation time to other physical properties. We test the inversion program on complex resistivity measurements of 12 core samples from the world-class gold deposit of Canadian Malartic. Results show that the Cole-Cole and Debye decomposition models converge quickly to a solution and often provide the best fit with experimental data. The Dias model requires the least amount of iterations to fully converge, but we note a small discrepancy between experimental data and mathematical model for most samples. Using petrographic analysis we test possible relationships between porosity, sulfur content and grain size with parameters obtained from the different models, and note that sulfur content influences both the chargeability and frequency dependence of the Cole-Cole model. Finally, we use our program to compare the different definitions of chargeability and relaxation time given by the three models. We note that these parameters tend to be correlated from one model to another. However, they have different electrochemical definitions and a single sample may possess different chargeability or relaxation time values depending on the model used. In the near future, the program will be used on a more extensive collection of samples from the Canadian Malartic gold deposit, the Highland Valley copper deposit, and the Millennium-McArthur uranium deposits. CMIC-NSERC Exploration Footprints Network Contribution 082

  1. 40 CFR 52.1638 - Bernalillo County particulate matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) New Mexico § 52.1638 Bernalillo County particulate matter (PM10) Group II SIP commitments. (a) On December 7, 1988, the Governor of New Mexico submitted a revision to the State Implementation Plan (SIP... SIPs. The City of Albuquerque and Bernalillo County Air Quality Control Board adopted this SIP revision...

  2. 40 CFR 52.1638 - Bernalillo County particulate matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) New Mexico § 52.1638 Bernalillo County particulate matter (PM10) Group II SIP commitments. (a) On December 7, 1988, the Governor of New Mexico submitted a revision to the State Implementation Plan (SIP... SIPs. The City of Albuquerque and Bernalillo County Air Quality Control Board adopted this SIP revision...

  3. 75 FR 28626 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10-029, Pilot Study--Cancer Survivorship Care Planning & SIP 10-030, Evaluating Special Events as a Recruitment Strategy for Cancer Screening, Initial Review In accordance...

  4. 76 FR 41186 - Salmonella Verification Sampling Program: Response to Comments on New Agency Policies and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Service [Docket No. FSIS-2008-0008] Salmonella Verification Sampling Program: Response to Comments on New... establishments that participate in SIP. The Agency intends to conduct its own unannounced, small- set sampling to... considering publishing verification sampling results for other product classes. In the 2006 Federal Register...

  5. 78 FR 54602 - Approval and Promulgation of State Implementation Plans; Utah: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Prevention of Significant Deterioration (PSD) program and other SIP provisions. These revisions were...'s regulations with the GHG emission thresholds established in EPA's ``PSD and Title V Greenhouse Gas... to approve the GHG (as it relates to the PSD program) revisions because the Agency has determined...

  6. Promoting School-University Partnerships: Professional Development of Teachers through the Collaborative School Improvement Program.

    ERIC Educational Resources Information Center

    Hackmann, Donald G.; Schmitt, Donna M.

    One method of training principals and teachers to lead substantive change initiatives lies in partnership activities between schools and the local university. The Collaborative School Improvement Program (C-SIP) is a successful school-university partnership that focuses upon collaborative relationships between Eastern Michigan University and area…

  7. 78 FR 7340 - Approval and Promulgation of Implementation Plans; Idaho: Sandpoint PM10 Nonattainment Area...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... Sandpoint City Ordinance 965 for control of residential burning because it strengthens the SIP. The EPA is... woodstoves and burning. The public awareness program provided citizens with information about stove sizing... uncertified solid fuel heating appliances, and implements a wood burning curtailment program in the City of...

  8. Ozone: Stage Two Vapor Recovery Rule and Guidance

    EPA Pesticide Factsheets

    This page includes the guidance document, fact sheet, memorandum, and final rule on removing Stage II Gasoline Vapor Control Programs from State Implementation Plans (SIP) for the Ozone National Ambient Air Quality Standards (NAAQS)

  9. EPA Approved Regulations in the Texas SIP

    EPA Pesticide Factsheets

    changed name to EPA Approved Regulations in the Texas SIP, Add links to:Texas Read Me; Texas SIP History;Current/Previous SIP-Approved Regulations; Delete regulations--now in /node/191099, removed tables

  10. Clone of EPA Approved Regulations in the Texas SIP

    EPA Pesticide Factsheets

    changed name to EPA Approved Regulations in the Texas SIP, Add links to:Texas Read Me; Texas SIP History;Current/Previous SIP-Approved Regulations; Delete regulations--now in /node/191099, removed tables

  11. Calibration of solar radiation measuring instruments. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bahm, R J; Nakos, J C

    A review of solar radiation measurement of instruments and some types of errors is given; and procedures for calibrating solar radiation measuring instruments are detailed. An appendix contains a description of various agencies who perform calibration of solar instruments and a description of the methods they used at the time this report was prepared. (WHK)

  12. A response strategy predicts acquisition of schedule-induced polydipsia in rats.

    PubMed

    Gregory, James Gardner; Hawken, Emily R; Banasikowski, Tomek J; Dumont, Eric C; Beninger, Richard J

    2015-08-03

    Schedule-induced polydipsia (SIP) is excessive, non-regulatory drinking. We aimed to identify phenotypic learning traits representative of neural circuitry that underlies SIP and hypothesized that rats that are response-learners will be more susceptible in developing compulsive water drinking. Using the Y-maze, the rats were characterized as either place- or response-learners. They were exposed to the SIP protocol for a period of 21days. Subsequent histological staining for FosB/ΔFosB examined neuronal activation associated with SIP in several brain regions. The rats with a preference for a response-learning strategy were more likely to develop SIP than the rats using a place-learning strategy. Furthermore amphetamine sensitization, observed to increase SIP, also shifted learning strategy to a response-learning strategy. No differences were observed in FosB/ΔFosB expression between SIP and non-SIP rats in the dorsolateral striatum (DLS) and CA1 region of the hippocampus. However, SIP rats had greater FosB/ΔFosB expression in prefrontal cortex regions. The rats that develop SIP have a preference for response-learning strategies and increased neuronal activation in frontal cortical regions associated with habit formation and compulsion. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy.

    PubMed

    Suzuki, Masatoshi; Boothman, David A

    2008-03-01

    Replicative senescence is a fundamental feature in normal human diploid cells and results from dysfunctional telomeres at the Hayflick cell division limit. Ionizing radiation (IR) prematurely induces the same phenotypes as replicative senescence prior to the Hayflick limit. This process is known as stress-induced premature senescence (SIPS). Since the cell cycle is irreversibly arrested in SIPS-induced cells, even if they are stimulated by various growth factors, it is thought that SIPS is a form of cell death, irreversibly eliminating replicating cells. IR-induced-focus formation of DNA repair proteins, a marker of DNA damage, is detected in SIPS as well as replicative senescent cells. Furthermore, both processes persistently induce cell cycle checkpoint mechanisms, indicating DNA damage created by ionizing radiation induces SIPS in normal cells, possibly by the same mechanisms as those occurring in replicative senescence. Interestingly, IR induces SIPS not only in normal cells, but also in tumor cells. Due to the expression of telomerase in tumor cells, telomere-dependent replicative senescence does not occur. However, SIPS is induced under certain conditions after IR exposure. Thus, cell death triggered by IR can be attributed to apoptosis or SIPS in tumor cells. However, metabolic function remains intact in SIPS-induced cancer cells, and recent studies show that senescence eliminate cells undergoing SIPS secrete various kinds of factors outside the cell, changing the microenvironment. Evidence using co-culture systems containing normal senescent stromal cells and epithelial tumor cells show that factors secreted from senescent stroma cells promote the growth of tumor epithelial cells both in vitro and in vivo. Thus, regulation of factors secreted from SIPS-induced stromal cells, as well as tumor cells, may affect radiotherapy.

  14. Social information processing in children: specific relations to anxiety, depression, and affect.

    PubMed

    Luebbe, Aaron M; Bell, Debora J; Allwood, Maureen A; Swenson, Lance P; Early, Martha C

    2010-01-01

    Two studies examined shared and unique relations of social information processing (SIP) to youth's anxious and depressive symptoms. Whether SIP added unique variance over and above trait affect in predicting internalizing symptoms was also examined. In Study 1, 215 youth (ages 8-13) completed symptom measures of anxiety and depression and a vignette-based interview measure of SIP. Anxiety and depression were each related to a more negative information-processing style. Only depression was uniquely related to a less positive information processing style. In Study 2, 127 youth (ages 10-13) completed measures of anxiety, depression, SIP, and trait affect. SIP's relations to internalizing symptoms were replicated. Over and above negative affect, negative SIP predicted both anxiety and depression. Low positive SIP added variance over and above positive affect in predicting only depression. Finally, SIP functioning partially mediated the relations of affect to internalizing symptoms.

  15. 75 FR 32190 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... Approaches To Preventing Teen Pregnancy Among Underserved Populations and SIP 10-035, Impact of High School... received in response to ``SIP 10-033, Innovative Approaches to Preventing Teen Pregnancy among Underserved...

  16. CacyBP/SIP as a regulator of transcriptional responses in brain cells

    PubMed Central

    Kilanczyk, Ewa; Filipek, Anna; Hetman, Michal

    2014-01-01

    Summary The Calcyclin-Binding Protein/Siah-1-Interacting Protein (CacyBP/SIP) is highly expressed in the brain and was shown to regulate the β-catenin-driven transcription in thymocytes. Therefore, it was investigated whether in brain cells CacyBP/SIP might play a role as a transcriptional regulator. In BDNF- or forskolin-stimulated rat primary cortical neurons, overexpression of CacyBP/SIP enhanced transcriptional activity of the cAMP-response element (CRE). In addition, overexpressed CacyBP/SIP enhanced BDNF-mediated activation of the Nuclear Factor of Activated T-cells (NFAT) but not the Serum Response Element (SRE). These stimulatory effects required an intact C-terminal domain of CacyBP/SIP. Moreover, in C6 rat glioma cells, the overexpressed CacyBP/SIP enhanced activation of CRE- or NFAT- following forskolin- or serum stimulation, respectively. Conversely, knockdown of endogenous CacyBP/SIP reduced activation of CRE- and NFAT but not SRE. Taken together, these results indicate that CacyBP/SIP is a novel regulator of CRE- and NFAT-driven transcription. PMID:25163685

  17. 76 FR 41158 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Regional Haze State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ...EPA is proposing a limited approval and a limited disapproval of a revision to the West Virginia State Implementation Plan (SIP) submitted by the State of West Virginia through the West Virginia Department of Environmental Protection (WVDEP) on June 18, 2008, that addresses regional haze for the first implementation period. This revision addresses the requirements of the Clean Air Act (CAA) and EPA's rules that require states to prevent any future, and remedy any existing, anthropogenic impairment of visibility in mandatory Class I areas caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is proposing a limited approval of this SIP revision to implement the regional haze requirements for West Virginia on the basis that the revision, as a whole, strengthens the West Virginia SIP. Also in this action, EPA is proposing a limited disapproval of this same SIP revision because of the deficiencies in the State's June 2008 regional haze SIP submittal arising from the remand by the U.S. Court of Appeals for the District of Columbia (D.C. Circuit) to EPA of the Clean Air Interstate Rule (CAIR). EPA is also proposing to approve this revision as meeting the requirements of 110(a)(2)(D)(i)(II) and 110(a)(2)(J), relating to visibility protection for the 1997 8-Hour Ozone National Ambient Air Quality Standard (NAAQS) and the 1997 and 2006 fine particulate matter (PM2.5) NAAQS.

  18. Impact of 50% Synthesized Iso-Paraffins (SIP) on F-76 Fuel Coalescence

    DTIC Science & Technology

    2013-12-16

    petroleum JP-5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic...manufactured scaled down filter/coalescer and separator to simulate the performance of a full-scale filter separator system. This test is designed to predict...5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic hydrocarbons

  19. SIPSim: A Modeling Toolkit to Predict Accuracy and Aid Design of DNA-SIP Experiments.

    PubMed

    Youngblut, Nicholas D; Barnett, Samuel E; Buckley, Daniel H

    2018-01-01

    DNA Stable isotope probing (DNA-SIP) is a powerful method that links identity to function within microbial communities. The combination of DNA-SIP with multiplexed high throughput DNA sequencing enables simultaneous mapping of in situ assimilation dynamics for thousands of microbial taxonomic units. Hence, high throughput sequencing enabled SIP has enormous potential to reveal patterns of carbon and nitrogen exchange within microbial food webs. There are several different methods for analyzing DNA-SIP data and despite the power of SIP experiments, it remains difficult to comprehensively evaluate method accuracy across a wide range of experimental parameters. We have developed a toolset (SIPSim) that simulates DNA-SIP data, and we use this toolset to systematically evaluate different methods for analyzing DNA-SIP data. Specifically, we employ SIPSim to evaluate the effects that key experimental parameters (e.g., level of isotopic enrichment, number of labeled taxa, relative abundance of labeled taxa, community richness, community evenness, and beta-diversity) have on the specificity, sensitivity, and balanced accuracy (defined as the product of specificity and sensitivity) of DNA-SIP analyses. Furthermore, SIPSim can predict analytical accuracy and power as a function of experimental design and community characteristics, and thus should be of great use in the design and interpretation of DNA-SIP experiments.

  20. SIPSim: A Modeling Toolkit to Predict Accuracy and Aid Design of DNA-SIP Experiments

    PubMed Central

    Youngblut, Nicholas D.; Barnett, Samuel E.; Buckley, Daniel H.

    2018-01-01

    DNA Stable isotope probing (DNA-SIP) is a powerful method that links identity to function within microbial communities. The combination of DNA-SIP with multiplexed high throughput DNA sequencing enables simultaneous mapping of in situ assimilation dynamics for thousands of microbial taxonomic units. Hence, high throughput sequencing enabled SIP has enormous potential to reveal patterns of carbon and nitrogen exchange within microbial food webs. There are several different methods for analyzing DNA-SIP data and despite the power of SIP experiments, it remains difficult to comprehensively evaluate method accuracy across a wide range of experimental parameters. We have developed a toolset (SIPSim) that simulates DNA-SIP data, and we use this toolset to systematically evaluate different methods for analyzing DNA-SIP data. Specifically, we employ SIPSim to evaluate the effects that key experimental parameters (e.g., level of isotopic enrichment, number of labeled taxa, relative abundance of labeled taxa, community richness, community evenness, and beta-diversity) have on the specificity, sensitivity, and balanced accuracy (defined as the product of specificity and sensitivity) of DNA-SIP analyses. Furthermore, SIPSim can predict analytical accuracy and power as a function of experimental design and community characteristics, and thus should be of great use in the design and interpretation of DNA-SIP experiments. PMID:29643843

  1. Teacher-Researchers in the "Zone of Proximal Development": Insights for Teacher Education.

    ERIC Educational Resources Information Center

    Torres, Myriam N.

    This study is part of a larger project on teacher research and professional development in the Teacher Enhancement Program (TEP), a master's degree mid-career collaborative program for inservice teachers. Research was initially planned and implemented as a new course which required teachers to do a Systematic Inquiry Project (SIP) in their…

  2. 40 CFR 51.368 - Public information and consumer protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... The SIP shall include a plan for informing the public on an ongoing basis throughout the life of the I/M program of the air quality problem, the requirements of Federal and State law, the role of motor vehicles in the air quality problem, the need for and benefits of an inspection program, how to maintain a...

  3. 40 CFR 51.368 - Public information and consumer protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... The SIP shall include a plan for informing the public on an ongoing basis throughout the life of the I/M program of the air quality problem, the requirements of Federal and State law, the role of motor vehicles in the air quality problem, the need for and benefits of an inspection program, how to maintain a...

  4. 40 CFR 51.368 - Public information and consumer protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... The SIP shall include a plan for informing the public on an ongoing basis throughout the life of the I/M program of the air quality problem, the requirements of Federal and State law, the role of motor vehicles in the air quality problem, the need for and benefits of an inspection program, how to maintain a...

  5. 40 CFR 51.368 - Public information and consumer protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... The SIP shall include a plan for informing the public on an ongoing basis throughout the life of the I/M program of the air quality problem, the requirements of Federal and State law, the role of motor vehicles in the air quality problem, the need for and benefits of an inspection program, how to maintain a...

  6. 77 FR 65305 - Approval of Air Quality Implementation Plans; California; San Joaquin Valley Unified Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... incorporates District Rule 2410-- Prevention of Significant Deterioration (PSD)--into the California SIP to establish a PSD permit program for pre-construction review of certain new and modified major stationary... provides an adequate PSD permitting program as required by section 110 and part C of title I of the CAA...

  7. Promoting an Alcohol-Free Childhood: A Novel Home-Based Parenting Program

    ERIC Educational Resources Information Center

    Dickinson, Denise M.; Hayes, Kim A.; Jackson, Christine; Ennett, Susan T.; Lawson, Caroline

    2014-01-01

    Few alcohol prevention programs focus on elementary school-aged youth, yet children develop expectancies and norms about alcohol use during the elementary school years, and many elementary school children are allowed to have sips or tastes of alcohol at home. Research on consequences of early alcohol use indicates that it can put children at…

  8. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year vehicles. (11) Waiver... 2001 and newer vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year... which will be achieved by the I/M program design in the SIP to those of the model program described in...

  9. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year vehicles. (11) Waiver... 2001 and newer vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year... which will be achieved by the I/M program design in the SIP to those of the model program described in...

  10. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year vehicles. (11) Waiver... 2001 and newer vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year... which will be achieved by the I/M program design in the SIP to those of the model program described in...

  11. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year vehicles. (11) Waiver... 2001 and newer vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year... which will be achieved by the I/M program design in the SIP to those of the model program described in...

  12. 40 CFR 51.351 - Enhanced I/M performance standard.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year vehicles. (11) Waiver... 2001 and newer vehicles. (10) Stringency. A 20% emission test failure rate among pre-1981 model year... which will be achieved by the I/M program design in the SIP to those of the model program described in...

  13. Early childhood trauma in high-risk families: associations with caregiver emotional availability and insightfulness, and children's social information processing and social behavior.

    PubMed

    Ziv, Yair; Umphlet, Kristen L Capps; Olarte, Stephanie; Venza, Jimmy

    2018-06-01

    The links between exposure to adverse childhood experiences (ACEs), caregiver insightfulness and emotional availability, and the child's social information processing (SIP) and social behavior were examined in a sample of 15 preschool children enrolled in a Therapeutic Nursery Program (TNP). Children are typically referred to the TNP due to significant delays in their social emotional development that often result in difficulty functioning in typical childcare, home, and community settings. Caregiver insightfulness was measured via an interview with the caregiver. Emotional availability was coded based on observations of caregiver-child interactions. The child's SIP patterns were measured in an interview, and the child's behavior in preschool was assessed by teacher reports. Higher levels of exposure to ACE were hypothesized to be related to lower levels of caregiver emotional availability and insightfulness and to higher levels of the children's perceptual (i.e. SIP) and behavioral maladjustment. It was also hypothesized that caregiver emotional availability and insightfulness would be associated with one another and significantly associated with children's perceptions and behaviors. Caregivers reporting higher levels of exposure exhibited lower levels of insightfulness and emotional availability. No such associations were found between the child's exposure to ACE and the caregivers' perceptions and behaviors. In addition, more insightful caregivers showed higher levels of emotional availability. Finally, children with more emotionally available caregivers showed more competent SIP and social behavior.

  14. Social Information Processing Mechanisms and Victimization: A Literature Review.

    PubMed

    van Reemst, Lisa; Fischer, Tamar F C; Zwirs, Barbara W C

    2016-01-01

    The aim of the current literature review, which is based on 64 empirical studies, was to assess to what extent mechanisms of the Social Information Processing (SIP) model of Crick and Dodge (1994) are related to victimization. The reviewed studies have provided support for the relation between victimization and several social information processing mechanisms, especially the interpretation of cues and self-efficacy (as part of the response decision). The relationship between victimization and other mechanisms, such as the response generation, was only studied in a few articles. Until now research has often focused on just one step of the model, instead of attempting to measure the associations between multiple mechanisms and victimization in multivariate analyses. Such analyses would be interesting to gain more insight into the SIP model and its relationship with victimization. The few available longitudinal studies show that mechanisms both predict victimization (internal locus of control, negative self-evaluations and less assertive response selection) and are predicted by victimization (hostile attribution of intent and negative evaluations of others). Associations between victimization and SIP mechanisms vary across different types and severity of victimization (stronger in personal and severe victimization), and different populations (stronger among young victims). Practice could focus on these stronger associations and the interpretation of cues. More research is needed however, to investigate whether intervention programs that address SIP mechanisms are suitable for victimization and all relevant populations. © The Author(s) 2014.

  15. CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation

    PubMed Central

    Zhai, Hui-Hong; Meng, Juan; Wang, Jing-Bo; Liu, Zhen-Xiong; Li, Yuan-Fei; Feng, Shan-Shan

    2014-01-01

    AIM: To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. METHODS: The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer cell lines that had been either unstimulated or stimulated with gastrin. To confirm the immunofluorescence findings, the relative abundance of CacyBP/SIP in nuclear and cytoplasmic compartments was assessed by Western blot. The effect of nuclear translocation of CacyBP/SIP on cell proliferation was examined using MTT assay. The colony formation assay was used to measure clonogenic cell survival. The effect of CacyBP/SIP nuclear translocation on cell cycle progression was investigated. Two CacyBP/SIP-specific siRNA vectors were designed and constructed to inhibit CacyBP/SIP expression in order to reduce the nuclear translocation of CacyBP/SIP, and the expression of CacyBP/SIP in stably transfected cells was determined by Western blot. The effect of inhibiting CacyBP/SIP nuclear translocation on cell proliferation was then assessed. RESULTS: CacyBP/SIP protein was present in most of gastric cancer cell lines. In unstimulated cells, CacyBP/SIP was distributed throughout the cytoplasm; while in stimulated cells, CacyBP/SIP was found mainly in the perinuclear region. CacyBP/SIP nuclear translocation generated a growth-stimulatory effect on cells. The number of colonies in the CacyBP/SIP nuclear translocation group was significantly higher than that in the control group. The percentage of stimulated cells in G1 phase was significantly lower than that of control cells (69.70% ± 0.46% and 65.80% ± 0.60%, control cells and gastrin-treated SGC7901 cells, P = 0.008; 72.99% ± 0.46% and 69.36% ± 0.51%, control cells and gastrin-treated MKN45 cells, P = 0.022). CacyBP/SIPsi1 effectively down-regulated the expression of CacyBP/SIP, and cells stably transfected by CacyBP/SIPsi1 were then chosen for further cellular assays. In CacyBP/SIPsi1 stably transfected cells, CacyBP/SIP was shown to be distributed throughout the cytoplasm, irregardless of whether they were stimulated or not. After CacyBP/SIP nuclear translocation was reduced, there had no major effect on cell proliferation, as shown by MTT assay. There had no enhanced anchorage-dependent growth upon stimulation, as indicated by colony formation in flat plates. No changes appeared in the percentage of cells in G0-G1 phase in either cell line (71.09% ± 0.16% and 70.86% ± 0.25%, control cells and gastrin-treated SGC7901-CacyBP/SIPsi1 cells, P = 0.101; 74.17% ± 1.04% and 73.07% ± 1.00%, control cells and gastrin-treated MKN45-CacyBP/SIPsi1 cells, P = 0.225). CONCLUSION: CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells. PMID:25110433

  16. CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.

    PubMed

    Zhai, Hui-Hong; Meng, Juan; Wang, Jing-Bo; Liu, Zhen-Xiong; Li, Yuan-Fei; Feng, Shan-Shan

    2014-08-07

    To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer cell lines that had been either unstimulated or stimulated with gastrin. To confirm the immunofluorescence findings, the relative abundance of CacyBP/SIP in nuclear and cytoplasmic compartments was assessed by Western blot. The effect of nuclear translocation of CacyBP/SIP on cell proliferation was examined using MTT assay. The colony formation assay was used to measure clonogenic cell survival. The effect of CacyBP/SIP nuclear translocation on cell cycle progression was investigated. Two CacyBP/SIP-specific siRNA vectors were designed and constructed to inhibit CacyBP/SIP expression in order to reduce the nuclear translocation of CacyBP/SIP, and the expression of CacyBP/SIP in stably transfected cells was determined by Western blot. The effect of inhibiting CacyBP/SIP nuclear translocation on cell proliferation was then assessed. CacyBP/SIP protein was present in most of gastric cancer cell lines. In unstimulated cells, CacyBP/SIP was distributed throughout the cytoplasm; while in stimulated cells, CacyBP/SIP was found mainly in the perinuclear region. CacyBP/SIP nuclear translocation generated a growth-stimulatory effect on cells. The number of colonies in the CacyBP/SIP nuclear translocation group was significantly higher than that in the control group. The percentage of stimulated cells in G1 phase was significantly lower than that of control cells (69.70% ± 0.46% and 65.80% ± 0.60%, control cells and gastrin-treated SGC7901 cells, P = 0.008; 72.99% ± 0.46% and 69.36% ± 0.51%, control cells and gastrin-treated MKN45 cells, P = 0.022). CacyBP/SIPsi1 effectively down-regulated the expression of CacyBP/SIP, and cells stably transfected by CacyBP/SIPsi1 were then chosen for further cellular assays. In CacyBP/SIPsi1 stably transfected cells, CacyBP/SIP was shown to be distributed throughout the cytoplasm, irregardless of whether they were stimulated or not. After CacyBP/SIP nuclear translocation was reduced, there had no major effect on cell proliferation, as shown by MTT assay. There had no enhanced anchorage-dependent growth upon stimulation, as indicated by colony formation in flat plates. No changes appeared in the percentage of cells in G0-G1 phase in either cell line (71.09% ± 0.16% and 70.86% ± 0.25%, control cells and gastrin-treated SGC7901-CacyBP/SIPsi1 cells, P = 0.101; 74.17% ± 1.04% and 73.07% ± 1.00%, control cells and gastrin-treated MKN45-CacyBP/SIPsi1 cells, P = 0.225). CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells.

  17. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.

    PubMed

    Manthey, Abby L; Lachke, Salil A; FitzGerald, Paul G; Mason, Robert W; Scheiblin, David A; McDonald, John H; Duncan, Melinda K

    2014-02-01

    SIP1 encodes a DNA-binding transcription factor that regulates multiple developmental processes, as highlighted by the pleiotropic defects observed in Mowat-Wilson syndrome, which results from mutations in this gene. Further, in adults, dysregulated SIP1 expression has been implicated in both cancer and fibrotic diseases, where it functionally links TGFβ signaling to the loss of epithelial cell characteristics and gene expression. In the ocular lens, an epithelial tissue important for vision, Sip1 is co-expressed with epithelial markers, such as E-cadherin, and is required for the complete separation of the lens vesicle from the head ectoderm during early ocular morphogenesis. However, the function of Sip1 after early lens morphogenesis is still unknown. Here, we conditionally deleted Sip1 from the developing mouse lens shortly after lens vesicle closure, leading to defects in coordinated fiber cell tip migration, defective suture formation, and cataract. Interestingly, RNA-Sequencing analysis on Sip1 knockout lenses identified 190 differentially expressed genes, all of which are distinct from previously described Sip1 target genes. Furthermore, 34% of the genes with increased expression in the Sip1 knockout lenses are normally downregulated as the lens transitions from the lens vesicle to early lens, while 49% of the genes with decreased expression in the Sip1 knockout lenses are normally upregulated during early lens development. Overall, these data imply that Sip1 plays a major role in reprogramming the lens vesicle away from a surface ectoderm cell fate towards that necessary for the development of a transparent lens and demonstrate that Sip1 regulates distinctly different sets of genes in different cellular contexts. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development

    PubMed Central

    Manthey, Abby L.; Lachke, Salil A.; FitzGerald, Paul G.; Mason, Robert W.; Scheiblin, David A.; McDonald, John H.; Duncan, Melinda K.

    2014-01-01

    SIP1 encodes a DNA-binding transcription factor that regulates multiple developmental processes, as highlighted by the pleiotropic defects observed in Mowat-Wilson Syndrome, which results from mutations in this gene. Further, in adults, dysregulated SIP1 expression has been implicated in both cancer and fibrotic diseases, where it functionally links TGFβ signaling to the loss of epithelial cell characteristics and gene expression. In the ocular lens, an epithelial tissue important for vision, Sip1 is co-expressed with epithelial markers, such as E-cadherin, and is required for the complete separation of the lens vesicle from the head ectoderm during early ocular morphogenesis. However, the function of Sip1 after early lens morphogenesis is still unknown. Here, we conditionally deleted Sip1 from the developing mouse lens shortly after lens vesicle closure, leading to defects in coordinated fiber cell tip migration, defective suture formation, and cataract. Interestingly, RNA-Sequencing analysis on Sip1 knockout lenses identified 190 differentially expressed genes, all of which are distinct from previously described Sip1 target genes. Furthermore, 34% of the genes with increased expression in the Sip1 knockout lenses are normally downregulated as the lens transitions from the lens vesicle to early lens, while 49% of the genes with decreased expression in the Sip1 knockout lenses are normally upregulated during early lens development. Overall, these data imply that Sip1 plays a major role in reprogramming the lens vesicle away from a surface ectoderm cell fate towards that necessary for the development of a transparent lens and demonstrate that Sip1 regulates distinctly different sets of genes in different cellular contexts. PMID:24161570

  19. The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells

    PubMed Central

    Yang, Bo; Li, Qianqian; Liu, Aiqin; Zhao, Yingying; Qiu, Changqing; Ge, Jun

    2018-01-01

    Background Calcyclin Binding Protein/(Siah-1 interacting protein) (CacyBP/SIP) acts as an oncogene in colorectal cancer. The nuclear accumulation of CacyBP/SIP has been linked to the proliferation of cancer cells. It has been reported that intracellular Ca2+ induces the nuclear translocation of CacyBP/SIP. However, the molecular mechanism of CacyBP/SIP nuclear translocation has yet to be elucidated. The purpose of this study was to test whether the Ca2+-dependent binding partner S100 protein is involved in CacyBP/SIP nuclear translocation in colon cancer SW480 cells. Methods The subcellular localization of endogenous CacyBP/SIP was observed following the stimulation of ionomycin or BAPTA/AM by immunofluorescence staining in SW480 cells. S100A6 small interfering RNAs (siRNA) were transfected into SW480 cells. Immunoprecipitation assays detected whether S100 protein is relevant to the nuclear translocation of CacyBP/SIP in response to changes in [Ca2+]i. Results We observed that endogenous CacyBP/SIP is translocated from the cytosol to the nucleus following the elevation of [Ca2+]i by ionomycin in SW480 cells. Co-immunoprecipitation experiments showed that the interaction between S100A6 and CacyBP/SIP was increased simultaneously with elevated Ca2+. Knockdown of S100A6 abolished the Ca2+ effect on the subcellular translocation of CacyBP/SIP. Conclusion Thus, we demonstrated that S100A6 is required for the Ca2+-dependent nuclear translocation of CacyBP/SIP in colon cancer SW480 cells. PMID:29534068

  20. Synergistic regulation of the acute phase protein SIP24/24p3 by glucocorticoid and pro-inflammatory cytokines.

    PubMed

    Liu, Quan-Sheng; Nilsen-Hamilton, Marit; Xiong, Si-Dong

    2003-10-25

    SIP24/24p3 is a secreted murine acute phase protein which has been speculated to play an anti-inflammatory role in vivo. Recently SIP24/24p3 has been found to be able to specifically induce apoptosis in leukocytes. By using (35)S metabolic labeling method, we studied the regulation of SIP24/24p3 by glucocorticoid and pro-inflammatory cytokines IL-6 and TNF-alpha in cultured Balb/c 3T3 and BNL cells. The following results were observed: (1) dexamethasone induced the expression of SIP24/24p3 in both Balb/c 3T3 and BNL cells, the induction was more significant in BNL cells; (2) dexamethasone and IL-6 synergistically induced the expression of SIP24/24p3 in both Balb/c 3T3 and BNL cells; (3) in Balb/c 3T3 cells dexamethasone and TNF-alpha acted synergistically to induce the expression of SIP24/24p3, whereas in BNL cells dexamethasone and TNF-alpha induced the expression of SIP24/24p3 in an additive manner; (4) dexamethasone and IL-6/TNF-alpha acted synergistically in Balb/c 3T3 cells and additively in BNL cells to induce the expression of SIP24/24p3. The inducibility of SIP24/24p3 by multiple factors will help to explain its highly specific expression in vivo. The difference in the expression patterns of SIP24/24p3 in different cell types is also suggestive to its expression and regulation in hepatic and extrahepatic tissues. Finally, the fact that SIP24/24p3 protein can be induced by both pro-inflammatory as well as anti-inflammatory factors is indicative of the important role of SIP24/24p3 in the entire acute phase response process.

  1. Where Are They Now? Nicole Pohida’s Passion for Nursing | Poster

    Cancer.gov

    After interning under three mentors at NCI at Frederick, former WHK intern Nicole Pohida is currently preparing to complete her undergraduate nursing degree at the University of Maryland. The aspiring nurse practitioner is passionate about doing the detective work necessary to solve challenging medical riddles, and she credits her mentors for helping stimulate her

  2. Development of a practical photochemical energy storage system. Quarterly report. [Interconversion between norbornadiene and quadricyclene for thermochemical heat storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hautala, R.R.; Kutal, C.R.

    1977-06-15

    Research on polymeric organic sensitizers and polymeric inorganic sensitizers for the conversion of norbornadine to quadricyclene and catalysts for the conversion of quadricyclene to norbornadine is described. The interconversion of norbornadine and quadricyclene is studied for its possible use for thermochemical solar energy storage. (WHK)

  3. NEANDC specialists meeting on yields and decay data of fission product nuclides

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chrien, R.E.; Burrows, T.W.

    Separate abstracts were prepared for the 29 papers presented. Workshop reports on decay heat, fission yields, beta- and gamma-ray spectroscopy, and delayed neutrons are included. An appendix contains a survey of the most recent compilations and evaluations containing fission product yield, fission product decay data, and delayed neutron yield information. (WHK)

  4. CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells

    PubMed Central

    Niu, Ying-Lin; Li, Ya-Jun; Wang, Jing-Bo; Lu, Yuan-Yuan; Liu, Zhen-Xiong; Feng, Shan-Shan; Hu, Jian-Guo; Zhai, Hui-Hong

    2016-01-01

    AIM: To investigate the mechanism of calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP) nuclear translocation in promoting the proliferation of gastric cancer (GC) cells. METHODS: The effect of CacyBP/SIP nuclear translocation on cell cycle was investigated by cell cycle analysis. Western blot analysis was used to assess the change in expression of cell cycle regulatory proteins and proteasome-mediated degradation of p27Kip1. Co-immunoprecipitation (co-IP) analysis was performed to examine the binding of CacyBP/SIP with Skp1. A CacyBP/SIP truncation mutant which lacked the Skp1 binding site was constructed and fused to a fluorescent protein. Subsequently, the effect on Skp1 binding with the fusion protein was examined by co-IP, while localization of fluorescent fusion protein observed by confocal laser microscopy, and change in p27Kip1 protein expression assessed by Western blot analysis. RESULTS: CacyBP/SIP nuclear translocation induced by gastrin promoted progression of GC cells from G1 phase. However, while CacyBP/SIP nuclear translocation was inhibited using siRNA to suppress CacyBP/SIP expression, cell cycle was clearly inhibited. CacyBP/SIP nuclear translocation significantly decreased the level of cell cycle inhibitor p27Kip1, increased Cyclin E protein expression whereas the levels of Skp1, Skp2, and CDK2 were not affected. Upon inhibition of CacyBP/SIP nuclear translocation, there were no changes in protein levels of p27Kip1 and Cyclin E, while p27Kip1 decrease could be prevented by the proteasome inhibitor MG132. Moreover, CacyBP/SIP was found to bind to Skp1 by immunoprecipitation, an event that was abolished by mutant CacyBP/SIP, which also failed to stimulate p27Kip1 degradation, even though the mutant could still translocate into the nucleus. CONCLUSION: CacyBP/SIP nuclear translocation contributes to the proliferation of GC cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1. PMID:27099442

  5. Changes in functional health status of older women with heart disease: evaluation of a program based on self-regulation.

    PubMed

    Clark, N M; Janz, N K; Dodge, J A; Schork, M A; Fingerlin, T E; Wheeler, J R; Liang, J; Keteyian, S J; Santinga, J T

    2000-03-01

    This study involving 570 women aged 60 years or older with heart disease, assessed the effects of a disease management program on physical functioning, symptom experience, and psychosocial status. Women were randomly assigned to control or program groups. Six to eight women met weekly with a health educator and peer leader over 4 weeks to learn self-regulation skills with physical activity as the focus. Evaluative data were collected through telephone interviews, physical assessments, and medical records at baseline and 4 and 12 months post baseline. At 12 months, compared with controls, program women were less symptomatic (p < .01), scored better on the physical dimension of the Sickness Impact Profile (SIP; p < 0.05), had improved ambulation as measured by the 6-minute walk (p < 0.01), and lost more body weight (p < .001). No differences related to psychosocial factors as measured by the SIP were noted. A self-regulation-based program that was provided to older women with heart disease and that focused on physical activity and disease management problems salient to them, improved their physical functioning and symptom experience. Psychosocial benefit was not evident and may be a result of measurement error or due to insufficient program time spent on psychosocial aspects of functioning.

  6. Design of a SIP device cooperation system on OSGi service platforms

    NASA Astrophysics Data System (ADS)

    Takayama, Youji; Koita, Takahiro; Sato, Kenya

    2007-12-01

    Home networks feature such various technologies as protocols, specifications, and middleware, including HTTP, UPnP, and Jini. A service platform is required to handle such technologies to enable them to cooperate with different devices. The OSGi service platform, which meets the requirements based on service-oriented architecture, is designed and standardized by OSGi Alliance and consists of two parts: one OSGi Framework and bundles. On the OSGi service platform, APIs are defined as services that can handle these technologies and are implemented in the bundle. By using the OSGi Framework with bundles, various technologies can cooperate with each other. On the other hand, in IP networks, Session Initiation Protocol (SIP) is often used in device cooperation services to resolve an IP address, control a session between two or more devices, and easily exchange the statuses of devices. However, since many existing devices do not correspond to SIP, it cannot be used for device cooperation services. A device that does not correspond to SIP is called an unSIP device. This paper proposes and implements a prototype system that enables unSIP devices to correspond to SIP. For unSIP devices, the proposed system provides device cooperation services with SIP.

  7. Testing Dialog-Verification of SIP Phones with Single-Message Denial-of-Service Attacks

    NASA Astrophysics Data System (ADS)

    Seedorf, Jan; Beckers, Kristian; Huici, Felipe

    The Session Initiation Protocol (SIP) is widely used for signaling in multimedia communications. However, many SIP implementations are still in their infancy and vulnerable to malicious messages. We investigate flaws in the SIP implementations of eight phones, showing that the deficient verification of SIP dialogs further aggravates the problem by making it easier for attacks to succeed. Our results show that the majority of the phones we tested are susceptible to these attacks.

  8. 40 CFR 52.1169 - Stack height review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....1169 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... limitations have been affected by stack height credits greater than good engineering practice or any other... under the Massachusetts SIP and our delegated PSD authority, the Department of Environmental Quality...

  9. SO2 NAAQS Implementation Training and Assistance for State and Local Air Agencies

    EPA Pesticide Factsheets

    Presentations and training help air agencies understand the National Ambient Air Quality Standards (NAAQS) for sulfur dioxide, how to engage the public in local emissions reduction programs, successful state implementation plan (SIP) development, and more.

  10. 40 CFR 52.370 - Identification of plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Nuclear Energy Company in Waterford, effective on October 13, 1995. (H) Connecticut Trading Agreement and... Northeast Nuclear Energy Company in Waterford. (H) SIP narrative materials, dated October 6, 1995, submitted... 52.370 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

  11. Social Information-Processing Skills and Aggression: A Quasi-Experimental Trial of the Making Choices and Making Choices Plus Programs

    ERIC Educational Resources Information Center

    Terzian, Mary A.; Li, Jilan; Fraser, Mark W.; Day, Steven H.; Rose, Roderick A.

    2015-01-01

    This article describes the findings from an efficacy trial of a school-based, universal prevention program designed to reduce aggressive behavior of by strengthening emotion regulation and social information-processing (SIP) skills. Three cohorts of third graders (N = 479) participated in this study. The first cohort participated in the Making…

  12. Strengthening the Social Information-Processing Skills of Children: A Controlled Test of the "Let's Be Friends" Program in China

    ERIC Educational Resources Information Center

    Wu, Fan; Fraser, Mark W.; Guo, Shenyang; Day, Steven H.; Galinsky, Maeda J.

    2016-01-01

    Objective: The study had two objectives (a) to adapt for Chinese children an intervention designed to strengthen the social information--processing (SIP) skills of children in the United States, and (b) to pilot test the adapted intervention in China. Methods: Adaptation of the "Making Choices" program involved reviewing Chinese…

  13. 76 FR 4076 - Approval and Promulgation of Implementation Plan and Operating Permits Program; State of Missouri

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... ago. (For example, 10 CSR 10-5.250 required existing sources to comply with emissions limitation no... identified in the approved SIP as 10 CSR 10- 2.150, 4.140, and 5.250, applicable to the Kansas City... to the Operating Permits Program (10 CSR 10-6.110). One revision changes the reporting threshold for...

  14. 76 FR 28437 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Preventive Services for Older Adults SIP11-045, and Measuring Impact of Multi-Component Interventions to Prevent Older Adult Falls and Assessing Sustainability and Scalability, SIP 11-046, Panel D,'' initial... SIP11-045, and Measuring Impact of Multi- Component Interventions to Prevent Older Adult Falls and...

  15. 40 CFR 52.1384 - Emission control regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... construction permit to override a requirement that has been approved as part of the SIP, are disapproved. We cannot approve these provisions into the SIP, as it would allow the State to change a SIP requirement through the issuance of a permit. Pursuant to section 110 of the Act, to change a requirement of the SIP...

  16. The Social Interaction Phobia Scale: Continued support for the psychometric validity of the SIPS using clinical and non-clinical samples.

    PubMed

    Menatti, Alison R; Weeks, Justin W; Carleton, R Nicholas; Morrison, Amanda S; Heimberg, Richard G; Hope, Debra A; Blanco, Carlos; Schneier, Franklin R; Liebowitz, Michael R

    2015-05-01

    The present study sought to extend findings supporting the psychometric validity of a promising measure of social anxiety (SA) symptoms, the Social Interaction Phobia Scale (SIPS; Carleton et al., 2009). Analyses were conducted using three samples: social anxiety disorder (SAD) patients, generalized anxiety disorder (GAD) patients, and healthy controls. SIPS scores of SAD patients demonstrated internal consistency and construct validity, and the previously demonstrated three-factor structure of the SIPS was replicated. Further, the SIPS total score uniquely predicted SA symptoms, and SIPS scores were significantly higher for SAD patients than GAD patients or controls. Two cut-off scores that discriminated SAD patients from GAD patients and from healthy controls were identified. The current study is the first to replicate the SIPS three-factor model in a large, treatment-seeking sample of SAD patients and establish a cut-off score discriminating SAD from GAD patients. Findings support the SIPS as a valid, SAD-specific assessment instrument. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1

    PubMed Central

    Wang, Miao; Pan, Li; Zhou, Peng; Lv, Jianliang; Zhang, Zhongwang; Wang, Yonglu; Zhang, Yongguang

    2015-01-01

    Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV). In this study, Lactobacillus plantarum strains NC8 and WCFS1 were used as oral delivery vehicles containing a pSIP411-VP1 recombinant plasmid to initiate mucosal and systemic immune responses in guinea pigs. Guinea pigs were orally vaccinated (three doses) with NC8-pSIP411, NC8-pSIP411-VP1, WCFS1-pSIP411, WCFS1-pSIP411-VP1 or milk. Animals immunized with NC8-pSIP411-VP1 and WCFS1-pSIP411-VP1 developed high levels of antigen-specific serum IgG, IgA, IgM, mucosal secretory IgA (sIgA) and neutralizing antibodies, and revealed stronger cell-mediated immune responses and enhanced protection against FMDV challenge compared with control groups. The recombinant pSIP411-VP1 effectively improved immunoprotection against FMDV in guinea pigs. PMID:26629822

  18. A recombinant truncated surface immunogenic protein (tSip) plus adjuvant FIA confers active protection against Group B streptococcus infection in tilapia.

    PubMed

    He, Yang; Wang, Kai-Yu; Xiao, Dan; Chen, De-Fang; Huang, Lingyuan; Liu, Tianqiang; Wang, Jun; Geng, Yi; Wang, Er-Long; Yang, Qian

    2014-12-05

    Tilapia is an important agricultural fish that has been plagued by Group B streptococcus (GBS) infections in recent years, some of them severe. It is well-known that surface immunogenicity protein (Sip) is an effective vaccine against GBS. Since Sip was not expressed in either E. coli BL21 or E. coli Rosetta, we removed the N-terminal signal peptide and LysM of the virus to produce purified truncated Sip (tSip(1)), which multiplied easily in an E. coli host. The antibody's ability to recognize and combine with GBS was determined by Western-blot and specific staining in vitro. The relative percentage of survival (RPS), antibody titers, bacterial recovery, and pathologic morphology were monitored in vivo to evaluate the immune effects. Freund's incomplete adjuvant (FIA) plus tSip and aluminum hydroxide gel (AH) plus tSip were also evaluated. It revealed that tSip mixed with FIA was an effective vaccine against GBS in tilapia, while AH is toxic to tilapia. Copyright © 2014. Published by Elsevier Ltd.

  19. CacyBP/SIP promotes the proliferation of colon cancer cells

    PubMed Central

    Chen, Xiong; Wang, Jun; Lu, Yuanyuan; Zhang, Faming; Liu, Zhengxiong; Lei, Ting; Fan, Daiming

    2017-01-01

    CacyBP/SIP is a component of the ubiquitin pathway and is overexpressed in several transformed tumor tissues, including colon cancer, which is one of the most common cancers worldwide. It is unknown whether CacyBP/SIP promotes the proliferation of colon cancer cells. This study examined the expression level, subcellular localization, and binding activity of CacyBP/SIP in human colon cancer cells in the presence and absence of the hormone gastrin. We found that CacyBP/SIP was expressed in a high percentage of colon cancer cells, but not in normal colonic surface epithelium. CacyBP/SIP promoted the cell proliferation of colon cancer cells under both basal and gastrin stimulated conditions as shown by knockdown studies. Gastrin stimulation triggered the translocation of CacyBP/SIP to the nucleus, and enhanced interaction between CacyBP/SIP and SKP1, a key component of ubiquitination pathway which further mediated the proteasome-dependent degradation of p27kip1 protein. The gastrin induced reduction in p27kip1 was prevented when cells were treated with the proteasome inhibitor MG132. These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1. PMID:28196083

  20. Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone

    PubMed Central

    Góral, Agnieszka; Bieganowski, Paweł; Prus, Wiktor; Krzemień-Ojak, Łucja; Kądziołka, Beata; Fabczak, Hanna; Filipek, Anna

    2016-01-01

    The Hsp90 chaperone activity is tightly regulated by interaction with many co-chaperones. Since CacyBP/SIP shares some sequence homology with a known Hsp90 co-chaperone, Sgt1, in this work we performed a set of experiments in order to verify whether CacyBP/SIP can interact with Hsp90. By applying the immunoprecipitation assay we have found that CacyBP/SIP binds to Hsp90 and that the middle (M) domain of Hsp90 is responsible for this binding. Furthermore, the proximity ligation assay (PLA) performed on HEp-2 cells has shown that the CacyBP/SIP-Hsp90 complexes are mainly localized in the cytoplasm of these cells. Using purified proteins and applying an ELISA we have shown that Hsp90 interacts directly with CacyBP/SIP and that the latter protein does not compete with Sgt1 for the binding to Hsp90. Moreover, inhibitors of Hsp90 do not perturb CacyBP/SIP-Hsp90 binding. Luciferase renaturation assay and citrate synthase aggregation assay with the use of recombinant proteins have revealed that CacyBP/SIP exhibits chaperone properties. Also, CacyBP/SIP-3xFLAG expression in HEp-2 cells results in the appearance of more basic Hsp90 forms in 2D electrophoresis, which may indicate that CacyBP/SIP dephosphorylates Hsp90. Altogether, the obtained results suggest that CacyBP/SIP is involved in regulation of the Hsp90 chaperone machinery. PMID:27249023

  1. Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype

    PubMed Central

    Ford, Matthew M.

    2014-01-01

    Schedule-induced polydipsia (SIP) is generated by subjecting a highly motivated animal to a sub-optimal rate of food reinforcement while also providing access to a fluid. SIP is one of several adjunctive (or displacement) behaviors that are expressed in an exaggerated form that is deemed ‘excessive’. This feature makes SIP an attractive model for studying an excessive ethanol drinking phenotype in rodents. Multiple experimental variables are crucial for the full manifestation of adjunctive drinking, including the degree of food deprivation, the inter-pellet interval selected, and the size of the food reward offered. Although these variables were extensively studied and optimized for water polydipsia in rats, a similarly customized approach to ethanol SIP and application of the procedure in mice have largely been curtailed in favor of the default variable values historically used for water SIP in rats. Further, ethanol SIP also requires careful consideration of variables such as taste and ethanol concentration. Investigation of the stress axis and neurochemical systems such as dopamine and serotonin in mediating adjunctive drinking stemmed from two leading hypotheses regarding the underlying mechanisms of SIP generation: 1) SIP as a coping strategy to mitigate stress associated with the aversive environmental condition, and 2) SIP as a displacement of reward in a highly motivated animal. Ethanol SIP is a powerful model of excessive intake because it can generate an ethanol-dependent state and sustain frequent and intoxicating levels of blood ethanol with voluntary oral consumption. The required food deprivation and the loss of the excessive drinking phenotype following removal of the generator schedule are the two main limitations of the model. Future utility of ethanol SIP will be enhanced by more fully dissecting the underlying hormonal and neurochemical mechanisms and optimizing experimental variables for ethanol SIP on a per species and strain basis. PMID:24680665

  2. Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype.

    PubMed

    Ford, Matthew M

    2014-05-01

    Schedule-induced polydipsia (SIP) is generated by subjecting a highly motivated animal to a sub-optimal rate of food reinforcement while also providing access to a fluid. SIP is one of several adjunctive (or displacement) behaviors that are expressed in an exaggerated form that is deemed 'excessive.' This feature makes SIP an attractive model for studying an excessive ethanol drinking phenotype in rodents. Multiple experimental variables are crucial for the full manifestation of adjunctive drinking, including the degree of food deprivation, the inter-pellet interval selected, and the size of the food reward offered. Although these variables were extensively studied and optimized for water polydipsia in rats, a similarly customized approach to ethanol SIP and application of the procedure in mice have largely been curtailed in favor of the default variable values historically used for water SIP in rats. Further, ethanol SIP also requires careful consideration of variables such as taste and ethanol concentration. Investigation of the stress axis and neurochemical systems such as dopamine and serotonin in mediating adjunctive drinking stemmed from two leading hypotheses regarding the underlying mechanisms of SIP generation: 1) SIP as a coping strategy to mitigate stress associated with the aversive environmental condition, and 2) SIP as a displacement of reward in a highly motivated animal. Ethanol SIP is a powerful model of excessive intake because it can generate an ethanol-dependent state and sustain frequent and intoxicating levels of blood ethanol with voluntary oral consumption. The required food deprivation and the loss of the excessive drinking phenotype following removal of the generator schedule are the two main limitations of the model. Future utility of ethanol SIP will be enhanced by more fully dissecting the underlying hormonal and neurochemical mechanisms and optimizing experimental variables for ethanol SIP on a per species and strain basis. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. (124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy.

    PubMed

    Tijink, Bernard M; Perk, Lars R; Budde, Marianne; Stigter-van Walsum, Marijke; Visser, Gerard W M; Kloet, Reina W; Dinkelborg, Ludger M; Leemans, C René; Neri, Dario; van Dongen, Guus A M S

    2009-08-01

    The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical radioimmunotherapy (RIT) trial with (131)I-L19-SIP was recently started. In the present study, after GMP production of (124)I and efficient production of (124)I-L19-SIP, we aimed to demonstrate the suitability of (124)I-L19-SIP immuno-PET for imaging of angiogenesis at early-stage tumour development and as a scouting procedure prior to clinical (131)I-L19-SIP RIT. (124)I was produced in a GMP compliant way via (124)Te(p,n)(124)I reaction and using a TERIMO module for radioiodine separation. L19-SIP was radioiodinated by using a modified version of the IODO-GEN method. The biodistribution of coinjected (124)I- and (131)I-L19-SIP was compared in FaDu xenograft-bearing nude mice, while (124)I PET images were obtained from mice with tumours of <50 to approximately 700 mm(3). (124)I was produced highly pure with an average yield of 15.4 +/- 0.5 MBq/microAh, while separation yield was approximately 90% efficient with <0.5% loss of TeO(2). Overall labelling efficiency, radiochemical purity and immunoreactive fraction were for (124)I-L19-SIP: approximately 80 , 99.9 and >90%, respectively. Tumour uptake was 7.3 +/- 2.1, 10.8 +/- 1.5, 7.8 +/- 1.4, 5.3 +/- 0.6 and 3.1 +/- 0.4%ID/g at 3, 6, 24, 48 and 72 h p.i., resulting in increased tumour to blood ratios ranging from 6.0 at 24 h to 45.9 at 72 h p.i.. Fully concordant labelling and biodistribution results were obtained with (124)I- and (131)I-L19-SIP. Immuno-PET with (124)I-L19-SIP using a high-resolution research tomograph PET scanner revealed clear delineation of the tumours as small as 50 mm(3) and no adverse uptake in other organs. (124)I-MAb conjugates for clinical immuno-PET can be efficiently produced. Immuno-PET with (124)I-L19-SIP appeared qualified for sensitive imaging of tumour neovasculature and for predicting (131)I-L19-SIP biodistribution.

  4. 76 FR 51925 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Adhesives and Sealants Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... http://www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know..., the Maryland Department of the Environment (MDE) submitted revisions to its SIP (Maryland SIP 08-02....11.35). On May 28, 2009, MDE submitted another revision to its SIP (Maryland SIP 09-01) amending...

  5. Decentralized session initiation protocol solution in ad hoc networks

    NASA Astrophysics Data System (ADS)

    Han, Lu; Jin, Zhigang; Shu, Yantai; Dong, Linfang

    2006-10-01

    With the fast development of ad hoc networks, SIP has attracted more and more attention in multimedia service. This paper proposes a new architecture to provide SIP service for ad hoc users, although there is no centralized SIP server deployed. In this solution, we provide the SIP service by the introduction of two nodes: Designated SIP Server (DS) and its Backup Server (BDS). The nodes of ad hoc network designate DS and BDS when they join the session nodes set and when some pre-defined events occur. A new sip message type called REGISTRAR is presented so nodes can send others REGISTRAR message to declare they want to be DS. According to the IP information taken in the message, an algorithm works like the election of DR and BDR in OSPF protocol is used to vote DS and BDS SIP servers. Naturally, the DS will be replaced by BDS when the DS is down for predicable or unpredictable reasons. To facilitate this, the DS should register to the BDS and transfer a backup of the SIP users' database. Considering the possibility DS or BDS may abruptly go down, a special policy is given. When there is no DS and BDS, a new election procedure is triggered just like the startup phase. The paper also describes how SIP works normally in the decentralized model as well as the evaluation of its performance. All sessions based on SIP in ad hoc such as DS voting have been tested in the real experiments within a 500m*500m square area where about 30 random nodes are placed.

  6. MHD retrofit of steam power plants. Feasibility study. Summary and conclusions, Part I

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1979-07-01

    The US Department of Energy Division of Magnetohydrodynamics (DOE/MHD) initiated this study to evaluate the feasibility of a retrofit option to reduce the time and cost of commercializing MHD. The MHD retrofit option will integrate a nominal 260 megawatt thermal (MWt) MHD topping cycle into an existing or scheduled private utility steam plant; this facility will test both the MHD system and the combined operation of the MHD/steam plant. The 260 MWt input level was determined to be the size which could most effectively demonstrate and verify the engineering design and operational characteristics of a coal-fired, open-cycle, MHD power plant.more » Details are presented. A goal of the MHD program is to have operational by the year 2003 a commercial size, fully integrated MHD plant. This would be accomplished by demonstrating commercial scale, baseload performance of a fully integrated, MHD/steam power plant. (WHK)« less

  7. Lightweight SIP/SDP compression scheme (LSSCS)

    NASA Astrophysics Data System (ADS)

    Wu, Jian J.; Demetrescu, Cristian

    2001-10-01

    In UMTS new IP based services with tight delay constraints will be deployed over the W-CDMA air interface such as IP multimedia and interactive services. To integrate the wireline and wireless IP services, 3GPP standard forum adopted the Session Initiation Protocol (SIP) as the call control protocol for the UMTS Release 5, which will implement next generation, all IP networks for real-time QoS services. In the current form the SIP protocol is not suitable for wireless transmission due to its large message size which will need either a big radio pipe for transmission or it will take far much longer to transmit than the current GSM Call Control (CC) message sequence. In this paper we present a novel compression algorithm called Lightweight SIP/SDP Compression Scheme (LSSCS), which acts at the SIP application layer and therefore removes the information redundancy before it is sent to the network and transport layer. A binary octet-aligned header is added to the compressed SIP/SDP message before sending it to the network layer. The receiver uses this binary header as well as the pre-cached information to regenerate the original SIP/SDP message. The key features of the LSSCS compression scheme are presented in this paper along with implementation examples. It is shown that this compression algorithm makes SIP transmission efficient over the radio interface without losing the SIP generality and flexibility.

  8. Creep Behavior of Structural Insulated Panels (SIPS): Results from a Pilot Study

    Treesearch

    Dwight McDonald; Marshall Begel; C. Adam Senalik; Robert Ross; Thomas D. Skaggs; Borjen Yeh; Thomas Williamson

    2014-01-01

    Structural insulated panels (SIPs) have been recognized as construction materials in the International Residential Code (IRC) since 2009. Although most SIPs are used in wall applications, they can also be used as roof or floor panels that are subjected to long-term transverse loading, for which SIP creep performance may be critical in design. However, limited...

  9. A statistical study on seismo-ionospheric precursors in the total electron content of global ionosphere map associated with M×6.0 earthquakes in the West Pacific region during 1998-2012

    NASA Astrophysics Data System (ADS)

    Liu, Jann-Yenq; Chen, Koichi; Tsai, Ho-Fang; Hattori, Katsumi; Le, Huijun

    2013-04-01

    This paper reports statistical results of seismo-ionospheric precursors (SIPs) of the total electron content (TEC) in the global ionosphere map (GIM) over the epicenter of earthquakes with magnitude 6 and greater in China, Japan, and Taiwan during 1998-2012. To detect SIP, a quartile-based (i.e. median-based) process is performed. The earthquakes are sub-divided into various regions to have a better understanding on SIP characteristics, as well as examined with and without being led by magnetic storms to confirm the SIP existence. Results show that the SIPs mainly are the TEC significant increase in Japan, and decrease in Taiwan and China, respectively, which suggests the latitudinal effect playing an important role. Meanwhile, for a practical application of monitoring SIPs, the GIM TEC at a fixed point is tested. Results show that multi monitoring points and/or a spatial observation are required to enhance the SIP detection.

  10. 78 FR 63887 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ..., revisions to the State of Iowa's State Implementation Plan (SIP), Title V program, and Clean Air Act (CAA..., subject to the requirements of sections 111(d) and 129 of the CAA, do not exist in the State; and... changes to the Title V program, pursuant to section 500 of the CAA. DATES: This rule is effective December...

  11. 40 CFR 52.1219 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1219 Identification of plan—conditional approval. (a) On November 12, 1993, the Minnesota Pollution Control Agency submitted a revision request to Minnesota's carbon monoxide SIP for approval of the State's basic inspection...

  12. 40 CFR 52.1219 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1219 Identification of plan—conditional approval. (a) On November 12, 1993, the Minnesota Pollution Control Agency submitted a revision request to Minnesota's carbon monoxide SIP for approval of the State's basic inspection...

  13. 40 CFR 52.1219 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1219 Identification of plan—conditional approval. (a) On November 12, 1993, the Minnesota Pollution Control Agency submitted a revision request to Minnesota's carbon monoxide SIP for approval of the State's basic inspection...

  14. 40 CFR 52.1219 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1219 Identification of plan—conditional approval. (a) On November 12, 1993, the Minnesota Pollution Control Agency submitted a revision request to Minnesota's carbon monoxide SIP for approval of the State's basic inspection...

  15. 40 CFR 52.1219 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1219 Identification of plan—conditional approval. (a) On November 12, 1993, the Minnesota Pollution Control Agency submitted a revision request to Minnesota's carbon monoxide SIP for approval of the State's basic inspection...

  16. 78 FR 25710 - Applications for New Awards; Strengthening Institutions Program (SIP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... priority in this notice: Carefully matched comparison group design means a type of quasi- experimental... notice). More specifically, it is a design in which project participants are matched with non... group study. When designing their study, applicants should consider participant characteristics relevant...

  17. California State Implementation Plan; Proposed Approval of Revisions; Northern Sonoma County Air Pollution Control District; Stationary Source Permits

    EPA Pesticide Factsheets

    EPA is proposing to approve revisions to the Northern Sonoma County Air Pollution Control District (NSCAPCD) portion of the California SIP concerning NSCAPCD's PSD permitting program for new and modified sources of air pollution.

  18. FHWA scanning report on traffic management and traveler information systems : FHWA's Scanning Program

    DOT National Transportation Integrated Search

    1997-11-01

    In response to the 1990 Clean Air Act Amendments (CAAA), areas designated as being in violation of the National Ambient Air Quality Standards (NAAQS) were required to submit State Implementation Plans (SIPs) beginning with 1990 Base Year Emissions In...

  19. 40 CFR 52.1832 - Stack height regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 52.1832 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... letter to Douglas M. Skie, EPA, dated May 11, 1988, Dana K. Mount, Director, Division of Environmental Engineering stated: * * * We are submitting this letter to allow EPA to continue to process our current SIP...

  20. A methodology of SiP testing based on boundary scan

    NASA Astrophysics Data System (ADS)

    Qin, He; Quan, Haiyang; Han, Yifei; Zhu, Tianrui; Zheng, Tuo

    2017-10-01

    System in Package (SiP) play an important role in portable, aerospace and military electronic with the microminiaturization, light weight, high density, and high reliability. At present, SiP system test has encountered the problem on system complexity and malfunction location with the system scale exponentially increase. For SiP system, this paper proposed a testing methodology and testing process based on the boundary scan technology. Combining the character of SiP system and referencing the boundary scan theory of PCB circuit and embedded core test, the specific testing methodology and process has been proposed. The hardware requirement of the under test SiP system has been provided, and the hardware platform of the testing has been constructed. The testing methodology has the character of high test efficiency and accurate malfunction location.

  1. SPS energy conversion and power management workshop. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1980-06-01

    In 1977 a four year study, the concept Development and Evaluation Program, was initiated by the US Department of Energy and the National Aeronautics and Space Administration. As part of this program, a series of peer reviews were carried out within the technical community to allow available information on SPS to be sifted, examined and, if need be, challenged. The SPS Energy Conversion and Power Management Workshop, held in Huntsville, Alabama, February 5 to 7, 1980, was one of these reviews. The results of studies in this particular field were presented to an audience of carefully selected scientists and engineers.more » This first report summarizes the results of that peer review. It is not intended to be an exhaustive treatment of the subject. Rather, it is designed to look at the SPS energy conversion and power management options in breadth, not depth, to try to foresee any troublesome and/or potentially unresolvable problems and to identify the most promising areas for future research and development. Topics include photovoltaic conversion, solar thermal conversion, and electric power distribution processing and power management. (WHK)« less

  2. Louisiana SIP: LAC 33:III Ch. 14 Subchap A, 1401 to 1415--Determining Conformity of General Federal Actions to State or Federal Implementation Plans; SIP effective 1996-11-12 (LAc67) and 1998-05-08 (LAc75)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 14 Subchap A, 1401 to 1415--Determining Conformity of General Federal Actions to State or Federal Implementation Plans; SIP effective 1996-11-12 (LAc67) and 1998-05-08 (LAc75)

  3. 40 CFR 57.205 - Submission of supplementary information upon relaxation of an SO2 SIP emission limitation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... upon relaxation of an SO2 SIP emission limitation. 57.205 Section 57.205 Protection of Environment... Application and the NSO Process § 57.205 Submission of supplementary information upon relaxation of an SO2 SIP emission limitation. (a) In the event an SO2 SIP limit is relaxed subsequent to EPA approval or issuance of...

  4. Louisiana SIP: LAC 33:III Ch 21 Subchap J, 2147--Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 1998-02-02 (LAc74) to more..

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch 21 Subchap J, 2147--Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 1998-02-02 (LAc74) more...

  5. Louisiana SIP: LAC 33:III Ch 2147. Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 2011-08-04 (LAd34) to 2017-09-27

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch 2147. Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 2011-08-04 (LAd34) to 2017-09-27

  6. Should we care about diurnal temperatures when calculating the precipitation isotope thermometer?

    NASA Astrophysics Data System (ADS)

    Vachon, R.; Kloeckner, D.

    2008-12-01

    Long records of the concentrations of stable isotopes of precipitation (SIPs) have long been used as proxies for regional and global climates for periods when meteorological measurements were not made. SIPs' longstanding correlation to local surface temperatures (in many locations) and molecular thermal dynamics have lead to many interpretations of variability in SIPs to be changes in local temperatures. In order to create accurate temperature-SIP transfer functions one needs to link modern SIP concentrations to temperatures of when precipitation happened. A well-sited example of complexities in the temperature-SIP relationships - For simplicity one may assume that annual precipitation occurred at the same time of year throughout a long SIP archive, however, it is possible that the timing of precipitation actually shifted from summer to winter months. If the temperature difference between the seasons is large the SIP archive could be wrongly interpreted as a several degree cooling in average annual temperatures. Temperature changes similar in magnitude to seasonal fluctuations are also observed throughout a given day. What would happen if precipitation shifted from mid-afternoon to nighttime events? This line of thinking implies that diurnal effects plausibly should be considered when calculating SIP-transfer functions. This is particularly convincing when precipitation for a region is powered by middle of the day (summer) heat causing convective precipitation or evening cooling increasing relative humidities near the land's surface. This study examines both theoretical and observed (5 locations within North America) surface temperatures at the time of precipitation throughout a day and estimates diurnal effects on SIP-transfer functions. Ultimately, one must ask, how high does condensation form, and what are daily temperature patterns at those heights?

  7. NMR Model of PrgI-SipD Interaction and its Implications in the Needle-Tip Assembly of the Salmonella Type III Secretion System

    PubMed Central

    Rathinavelan, Thenmalarchelvi; Lara-Tejero, Maria; Lefebre, Matthew; Chatterjee, Srirupa; McShan, Andrew C.; Guo, Da-Chuan; Tang, Chun; Galan, Jorge E.; De Guzman, Roberto N.

    2014-01-01

    Salmonella and other pathogenic bacteria use the type III secretion system (T3SS) to inject virulence proteins into human cells to initiate infections. The structural component of the T3SS contains a needle and a needle tip. The needle is assembled from PrgI needle protomers and the needle tip is capped with several copies of the SipD tip protein. How a tip protein docks on the needle is unclear. A crystal structure of a PrgI-SipD fusion protein docked on the PrgI needle results in steric clash of SipD at the needle tip when modeled on the recent atomic structure of the needle. Thus, there is currently no good model of how SipD is docked on the PrgI needle tip. Previously, we showed by NMR paramagnetic relaxation enhancement (PRE) methods that a specific region in the SipD coiled-coil is the binding site for PrgI. Others have hypothesized that a domain of the tip protein – the N-terminal α-helical hairpin, has to swing away during the assembly of the needle apparatus. Here, we show by PRE methods that a truncated form of SipD lacking the α-helical hairpin domain binds more tightly to PrgI. Further, PRE-based structure calculations revealed multiple PrgI binding sites on the SipD coiled-coil. Our PRE results together with the recent NMR-derived atomic structure of the Salmonella needle suggest a possible model of how SipD might dock at the PrgI needle tip. SipD and PrgI are conserved in other bacterial T3SSs, thus our results have wider implication in understanding other needle-tip complexes. PMID:24951833

  8. Dimerization and phosphatase activity of calcyclin-binding protein/Siah-1 interacting protein: the influence of oxidative stress

    PubMed Central

    Topolska-Woś, Agnieszka M.; Shell, Steven M.; Kilańczyk, Ewa; Szczepanowski, Roman H.; Chazin, Walter J.; Filipek, Anna

    2015-01-01

    CacyBP/SIP [calcyclin-binding protein/Siah-1 [seven in absentia homolog 1 (Siah E3 ubiquitin protein ligase 1)] interacting protein] is a multifunctional protein whose activity includes acting as an ERK1/2 phosphatase. We analyzed dimerization of mouse CacyBP/SIP in vitro and in mouse neuroblastoma cell line (NB2a) cells, as well as the structure of a full-length protein. Moreover, we searched for the CacyBP/SIP domain important for dimerization and dephosphorylation of ERK2, and we analyzed the role of dimerization in ERK1/2 signaling in NB2a cells. Cell-based assays showed that CacyBP/SIP forms a homodimer in NB2a cell lysate, and biophysical methods demonstrated that CacyBP/SIP forms a stable dimer in vitro. Data obtained using small-angle X-ray scattering supported a model in which CacyBP/SIP occupies an anti-parallel orientation mediated by the N-terminal dimerization domain. Site-directed mutagenesis established that the N-terminal domain is indispensable for full phosphatase activity of CacyBP/SIP. We also demonstrated that the oligomerization state of CacyBP/SIP as well as the level of post-translational modifications and subcellular distribution of CacyBP/SIP change after activation of the ERK1/2 pathway in NB2a cells due to oxidative stress. Together, our results suggest that dimerization is important for controlling phosphatase activity of CacyBP/SIP and for regulating the ERK1/2 signaling pathway.—Topolska-Woś, A. M., Shell, S. M., Kilańczyk, E., Szczepanowski, R. H., Chazin, W. J., Filipek, A. Dimerization and phosphatase activity of calcyclin-binding protein/Siah-1 interacting protein: the influence of oxidative stress. PMID:25609429

  9. California Air Quality State Implementation Plans; Final Approval; Butte County Air Quality Management District; Stationary Source Permits

    EPA Pesticide Factsheets

    EPA is taking final action to approve a revision to the Butte County Air Quality Management District (BCAQMD) portion of the California State Implementation Plan (SIP). This revision concerns the District's New Source Review (NSR) permitting program.

  10. 40 CFR 52.2119 - Identification of plan-conditional approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) South Carolina § 52.2119 Identification of plan-conditional approval. EPA is conditionally approving a revision to the South Carolina State Implementation Plan (SIP) consisting of a new Standard (South Carolina Regulation 61-62.5 Standard...

  11. Reliability and Validity of the Alcohol Short Index of Problems and a Newly Constructed Drug Short Index of Problems*

    PubMed Central

    Alterman, Arthur I.; Cacciola, John S.; Ivey, Megan A.; Lynch, Kevin G.

    2009-01-01

    Objective: This study evaluated the psychometric properties of the 15-item alcohol Short Index of Problems (SIP) instrument and those of a newly constructed 15-item drug Short Index of Problems (SIP-D) instrument in 277 newly entered substance-abuse patients. Method: The SIP is derived from the longer, 50-item Drinker Inventory of Consequences (DrInC), which was designed to assess adverse consequences of alcohol use. The SIP-D was constructed by substituting the term “drug use” for the term “drinking” in each SIP item. A 3-month recall interval was employed. Results: Factor analyses of each of the instruments revealed similar solutions, with only one main factor accounting for the majority of variance. Nonparametric item response theory methods produced the same finding. Internal consistency reliability estimates for the SIP and SIP-D total scores were .98 and .97, respectively. Concurrent validity was demonstrated by examining the correlations of the total scores for each of the instruments with the recent summary indexes of the newly revised Addiction Severity Index (ASI-Version 6): alcohol, drug, medical, economic, legal, family/social, and psychiatric problems. Conclusions: This study is the first to confirm the psychometric validity of the SIP when used as an independent instrument unembedded within the DrInC. The study also supports the use of the SIP-D as a brief measure of adverse consequences of drug use. The findings strongly support the unidimensional structure of both measures. PMID:19261243

  12. Reliability and validity of the alcohol short index of problems and a newly constructed drug short index of problems.

    PubMed

    Alterman, Arthur I; Cacciola, John S; Ivey, Megan A; Habing, Brian; Lynch, Kevin G

    2009-03-01

    This study evaluated the psychometric properties of the 15-item alcohol Short Index of Problems (SIP) instrument and those of a newly constructed 15-item drug Short Index of Problems (SIP-D) instrument in 277 newly entered substance-abuse patients. The SIP is derived from the longer, 50-item Drinker Inventory of Consequences (DrInC), which was designed to assess adverse consequences of alcohol use. The SIP-D was constructed by substituting the term "drug use" for the term "drinking" in each SIP item. A 3-month recall interval was employed. Factor analyses of each of the instruments revealed similar solutions, with only one main factor accounting for the majority of variance. Nonparametric item response theory methods produced the same finding. Internal consistency reliability estimates for the SIP and SIP-D total scores were .98 and .97, respectively. Concurrent validity was demonstrated by examining the correlations of the total scores for each of the instruments with the recent summary indexes of the newly revised Addiction Severity Index (ASI-Version 6): alcohol, drug, medical, economic, legal, family/social, and psychiatric problems. This study is the first to confirm the psychometric validity of the SIP when used as an independent instrument unembedded within the DrInC. The study also supports the use of the SIP-D as a brief measure of adverse consequences of drug use. The findings strongly support the unidimensional structure of both measures.

  13. The small serine-threonine protein SIP2 interacts with STE12 and is involved in ascospore germination in Sordaria macrospora.

    PubMed

    Elleuche, Skander; Bernhards, Yasmine; Schäfers, Christian; Varghese, Jans Manjali; Nolting, Nicole; Pöggeler, Stefanie

    2010-12-01

    In fungi, the homoeodomain protein STE12 controls diverse developmental processes, and derives its regulatory specificity from different protein interactions. We recently showed that in the homothallic ascomycete Sordaria macrospora, STE12 is essential for ascospore development, and is able to interact with the alpha-domain mating-type protein SMTA-1 and the MADS box protein MCM1. To further evaluate the functional roles of STE12, we used the yeast two-hybrid approach to identify new STE12-interacting partners. Using STE12 as bait, a small, serine-threonine-rich protein (designated STE12-interacting protein 2, SIP2) was identified. SIP2 is conserved among members of the fungal class Sordariomycetes. In vivo localization studies revealed that SIP2 was targeted to the nucleus and cytoplasm. The STE12/SIP2 interaction was further confirmed in vivo by bimolecular fluorescence complementation. Nuclear localization of SIP2 was apparently mediated by STE12. Unlike deletion of ste12, deletion of sip2 in S. macrospora led to only a slight decrease in ascospore germination, and no other obvious morphological phenotype. In comparison to the Δste12 single knockout strain, ascospore germination was significantly increased in a Δsip2/ste12 double knockout strain. Our data provide evidence for a regulatory role of the novel fungal protein SIP2 in ascospore germination. Copyright © 2010 Elsevier GmbH. All rights reserved.

  14. Proceedings of the second United Nations symposium on the development and use of geothermal resources. Volume 2 (in several languages)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Separate abstracts were prepared for 69 of the 77 papers presented. The remaining 7 papers were previously abstracted in ERA and can be found in the report number index under CONF-750525. The papers presented are under sections entitled geophysical techniques in exploration, environmental factors and waste disposal, and drilling technology. (WHK)

  15. WHK Interns Sweep Entire Category at Frederick County Science Fair | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer The competitors in the cellular and molecular biology category of the Frederick County Science and Engineering Fair on March 22–23 didn’t stand a chance against the Werner H. Kirsten student interns at the National Cancer Institute at Frederick. These interns swept the entire category, with Madelyne Xiao, a rising intern, winning first place;

  16. Conversion system overview assessment. Volume 1: solar thermoelectrics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jayadev, T. S.; Henderson, J.; Finegold, J.

    1979-08-01

    An assessment of thermoelectrics for solar energy conversion is given. There is significant potential for solar thermoelectrics in solar technologies where collector costs are low; e.g., Ocean Thermal Energy Conversion (OTEC) and solar ponds. Reports of two studies by manufacturers assessing the cost of thermoelectric generators in large scale production are included in the appendix and several new concepts thermoelectric systems are presented. (WHK)

  17. Former Intern: Amy Stull Returns to Her Roots | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer When Amy Stull, a 2000 graduate of Walkersville High School, began working in a laboratory at the National Cancer Institute (NCI) at Frederick, she likely did not know the role NCI would play in her career. Stull started at NCI as a Werner H. Kirsten (WHK) student intern after her junior year of high school, working in a lab as she

  18. Student Intern Freed Competes at Intel ISEF, Two Others Awarded at Local Science Fair | Poster

    Cancer.gov

    Class of 2014–2015 Werner H. Kirsten (WHK) student intern Rebecca “Natasha” Freed earned a fourth-place award in biochemistry at the 2015 Intel International Science and Engineering Fair (ISEF), the largest high school science research competition in the world, according to the Society for Science & the Public’s website. Freed described the event as “transformative

  19. Louisiana SIP: LAC 33:III Ch. 7 Section 701. Purpose and Information Regarding Standards for PM10, SO2, CO, Atmospheric Oxidants, NOx and Pb; SIP effective 1989-05-08 (LAc49) to 2011-08-03 (LAd34 - Revised)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 7 Section 701. Purpose and Information Regarding Standards for PM10, SO2, CO, Atmospheric Oxidants, NOx and Pb; SIP effective 1989-05-08 (LAc49) to 2011-08-03 (LAd34 - Revised)

  20. 40 CFR 51.125 - Emissions reporting requirements for SIP revisions relating to budgets for SO2 and NOX emissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SIP revisions relating to budgets for SO2 and NOX emissions. 51.125 Section 51.125 Protection of... SIP revisions relating to budgets for SO2 and NOX emissions. (a) For its transport SIP revision under § 51.123 and/or 51.124, each State must submit to EPA SO2 and/or NOX emissions data as described in...

  1. Louisiana SIP: LAC 33:III Ch 2132. Stage II Vapor Recovery Systems for Control of Vehicle Refuelling Emissions at Gasoline Dispensing Facilities; SIP effective 2011-08-04 (LAd34) and 2016-02-29 (LAd47) to 2017-09-27

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch 2132. Stage II Vapor Recovery Systems for Control of Vehicle Refuelling Emissions at Gasoline Dispensing Facilities; SIP effective 2011-08-04 (LAd34) and 2016-02-29 (LAd47) to 2017-09-27

  2. Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia.

    PubMed

    Levine, R; Levine, S

    1989-06-01

    Adrenalectomized female rats failed to develop schedule-induced polydipsia (SIP). Dexamethasone (DEX) injections failed to reinstate SIP in adrenalectomized rats. They did not prevent intact rats from acquiring SIP but interfered with subsequent expression of this behavior. In contrast, corticosterone, the rats' normally occurring glucocorticoid, fully restored the acquisition and subsequent expression of SIP in adrenalectomized rats. This strongly suggests that corticosterone plays an essential role in the normal acquisition and development of this behavior. Data are interpreted in the context of current information concerning adrenal hormone receptors. It is hypothesized SIP acquisition is at least partly regulated by the Type I (mineralocorticoid) receptor.

  3. Streamlining the SIP Process

    EPA Pesticide Factsheets

    EPA collaborated with the The National Association of Clean Air Agencies (NACAA/ECOs) SIP Reform Work Group to minimize federal and state burden in developing SIPs, but ensure the plans effectiveness in complying with the Clean Air Act.

  4. PERP, a host tetraspanning membrane protein, is required for S almonella‐induced inflammation

    PubMed Central

    Hallstrom, Kelly N.; Srikanth, C. V.; Agbor, Terence A.; Dumont, Christopher M.; Peters, Kristen N.; Paraoan, Luminita; Casanova, James E.; Boll, Erik J.

    2015-01-01

    Summary S almonella enterica  Typhimurium induces intestinal inflammation through the activity of type III secreted effector (T3SE) proteins. Our prior results indicate that the secretion of the T3SE SipA and the ability of SipA to induce epithelial cell responses that lead to induction of polymorphonuclear transepithelial migration are not coupled to its direct delivery into epithelial cells from S almonella. We therefore tested the hypothesis that SipA interacts with a membrane protein located at the apical surface of intestinal epithelial cells. Employing a split ubiquitin yeast‐two‐hybrid screen, we identified the tetraspanning membrane protein, p53 effector related to PMP‐22 (PERP), as a SipA binding partner. SipA and PERP appear to have intersecting activities as we found PERP to be involved in proinflammatory pathways shown to be regulated by SipA. In sum, our studies reveal a critical role for PERP in the pathogenesis of S. Typhimurium, and for the first time demonstrate that SipA, a T3SE protein, can engage a host protein at the epithelial surface. PMID:25486861

  5. Antenatal magnesium sulfate and spontaneous intestinal perforation in infants less than 25 weeks gestation.

    PubMed

    Rattray, B N; Kraus, D M; Drinker, L R; Goldberg, R N; Tanaka, D T; Cotten, C M

    2014-11-01

    Evaluate spontaneous intestinal perforation (SIP)/death among extremely low birthweight (ELBW) infants before, during and after initiation of an antenatal magnesium for neuroprotection protocol (MgPro). We tested associations between SIP/death and magnesium exposure, gestational age (GA) and interactions with GA and magnesium exposure in a cohort of inborn ELBW infants before, during and after MgPro. One hundred and fifty-five ELBW infants were included, 81 before, 23 during and 51 after MgPro. ELBW infants (78.3%) were exposed to Mg during MgPro compared with 50.6% and 60.8% before and after, respectively. Incidence of SIP on protocol was 30.4% vs 12.9% off protocol (P=0.03). GA was strongly associated with SIP (P<0.01). Antenatal Mg dose was also associated with SIP/death regardless of epoch (odds ratio 9.3 (1.04-104.6)), but increased SIP/death was limited to those <25 weeks gestation. Higher Mg dose was associated with higher SIP and death risk among infants with the lowest birthweights. Validation of this observation in larger populations is warranted.

  6. The development of a purification procedure for saxitoxin-induced protein.

    PubMed

    Smith, D S; Kitts, D D; Fenske, B; Owen, T G; Shyng, S

    1995-02-01

    A simple economical procedure for purifying saxitoxin-induced protein (SIP) from crude extracts of the small shore crab, Hemigrapsus oregenesis, was developed. (NH4)2SO4 precipitation, chymotrypsin digestion, heat treatment, gel filtration and ion-exchange-chromatography procedures were evaluated in purifying SIP. An enzyme immunoassay was used to determine the SIP yield and relative purity at each step of three procedures, thus permitting an assessment of the conditions required for maximum recovery. Response surface analysis was used in an attempt to determine the optimum temperature and exposure time for the heat treatment. A 20 min incubation at 65 degrees C was confirmed by electrophoretic analysis to be the best combination of time and temperature for achieving both an acceptable yield and purity of SIP. SIP in desalted concentrate was shown to be resistant to chymotrypsin proteolysis; however, this enzyme had deleterious effects on SIP purification at later stages of the procedure. The omission of the chymotrypsin digestion, and the inclusion of gel-filtration chromatography in the final clean-up step, resulted in the purification of SIP comparable with that achieved with affinity chromatography.

  7. Strategic tree planting as an EPA encouraged pollutant reduction strategy: how urban trees can obtain credit in state implementation plans

    Treesearch

    Dr. David J. Nowak

    2005-01-01

    As tree programs are new to the SIP process, "to facilitate Federal approval of an emerging or voluntary measure States are encouraged to work with their EPA regional ofice during the development process". Programs to increase canopy cover in urban areas can achieve many benefits. They can help improve air and water quality, as well as other factors related...

  8. Guidance on Streamlining the SIP Process

    EPA Pesticide Factsheets

    EPA collaborated with the The National Association of Clean Air Agencies (NACAA/ECOs) SIP Reform Work Group to minimize federal and state burden in developing SIPs, but ensure the plans effectiveness in complying with the Clean Air Act.

  9. 40 CFR 52.146 - Particulate matter (PM-10) Group II SIP commitments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... submitted a revision to the State Implementation Plan (SIP) for Casa Grande, Show Low, Safford, Flagstaff... Implementation Plan (SIP) requirements for Casa Grande, Show Low, Safford, Flagstaff and Joseph City as provided...

  10. Infrastructure SIP Requirements and Guidance

    EPA Pesticide Factsheets

    The Clean Air Act requires states to submit SIPs that implement, maintain, and enforce a new or revised national ambient air quality standard (NAAQS) within 3 years of EPA issuing the standard. The Infrastructure SIP is required for all states.

  11. Thermal Control of the Scientific Instrument Package in the Large Space Telescope

    NASA Technical Reports Server (NTRS)

    Hawks, K. H.

    1972-01-01

    The general thermal control system philosophy was to utilize passive control where feasible and to utilize active methods only where required for more accurate thermal control of the SIP components with narrow temperature tolerances. A thermal model of the SIP and a concept for cooling the SIP cameras are presented. The model and cooling concept have established a rationale for determining a Phase A baseline for SIP thermal control.

  12. Instant Messaging by SIP

    NASA Astrophysics Data System (ADS)

    Muhi, Daniel; Dulai, Tibor; Jaskó, Szilárd

    2008-11-01

    SIP is a general-purpose application layer protocol which is able to establish sessions between two or more parties. These sessions are mainly telephone calls and multimedia conferences. However it can be used for other purposes like instant messaging and presence service. SIP has a very important role in mobile communication as more and more communicating applications are going mobile. In this paper we would like to show how SIP can be used for instant messaging purposes.

  13. 77 FR 27162 - Notice of Data Availability Supporting Approval and Promulgation of Air Quality Implementation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ...EPA proposed on April 25, 2012 (77 FR 24794) to take action on a revision to the state implementation plan (SIP) addressing regional haze submitted by the State of New York. In that proposal, EPA proposed to address through a Federal Implementation Plan (FIP) certain requirements not addressed in New York's regional haze SIP submission or, alternatively, to approve a substantively identical SIP revision by New York, should the State timely submit such a revision. In two letters dated April 16, 2012, New York submitted additional materials relevant to our proposed action on its regional haze SIP submission, including proposed SIP revisions addressing the requirements for best available retrofit technology controls (BART) for a number of sources. EPA is providing notice of availability of these materials. The comment period on EPA's proposed action on the New York regional haze SIP closes on June 18, 2010.

  14. 40 CFR 52.1230 - Control strategy and rules: Particulates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Minnesota § 52.1230 Control strategy and rules: Particulates. (a) Part D(1) Approval. The State of Minnesota has satisfied the... provision of Rule 7005.2910. (b) Approval—On May 31, 1988, the State of Minnesota submitted a committal SIP...

  15. Rational Numbers in Content and Methods Courses for Teacher Preparation.

    ERIC Educational Resources Information Center

    Pesek, Dolores D.; Gray, Elizabeth D.; Golding, Tena L.

    Over the past five years, Pesek (Simoneaux), Gray and Golding have been actively involved in the Louisiana Systemic Initiative Program (LaSIP) and the Louisiana Collaborative for Excellence in the Preparation of Teachers (LACEPT) grants through Southeastern Louisiana University. Through these grants teachers from the region are inserviced on…

  16. 75 FR 34671 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Limiting Emissions of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... From Consumer Products AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY....0--Consumer Products to Delaware's Regulation 1141 (formerly SIP Regulation No. 41)--Limiting... Fernandez, Office of Air Program Planning, Mailcode 3AP30, U.S. Environmental Protection Agency, Region III...

  17. 77 FR 17044 - Applications for New Awards; Strengthening Institutions Program (SIP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... 27637), and apply to the priorities in this notice: Carefully matched comparison group design means a... make when designing a carefully matched comparison group study. Applicants might want to consider...) or not to participate in the project (control group). The effect of the project is the average...

  18. METHODOLOGIES FOR ESTIMATING AIR EMISSIONS FROM THREE NON-TRADITIONAL SOURCE CATEGORIES: OIL SPILLS, PETROLEUM VESSEL LOADING & UNLOADING, AND COOLING TOWERS

    EPA Science Inventory

    The report discusses part of EPA's program to identify and characterize emissions sources not currently accounted for by either the existing Aerometric Information Retrieval System (AIRS) or State Implementation Plan (sip) area source methodologies and to develop appropriate emis...

  19. 46 CFR 8.530 - Plan development and approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Plan development and approval. 8.530 Section 8.530 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Streamlined Inspection Program § 8.530 Plan development and approval. The Company SIP Agent will...

  20. 46 CFR 8.530 - Plan development and approval.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Plan development and approval. 8.530 Section 8.530 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Streamlined Inspection Program § 8.530 Plan development and approval. The Company SIP Agent will...

  1. 77 FR 30212 - Approval and Promulgation of Air Quality Implementation Plans; Vermont; Regional Haze

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... Promulgation of Air Quality Implementation Plans; Vermont; Regional Haze AGENCY: Environmental Protection... Implementation Plan (SIP) that addresses regional haze for the first planning period from 2008 through 2018. The... numerous sources located over a wide geographic area (also referred to as the ``regional haze program...

  2. 40 CFR 51.368 - Public information and consumer protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Public information and consumer.../Maintenance Program Requirements § 51.368 Public information and consumer protection. (a) Public awareness. The SIP shall include a plan for informing the public on an ongoing basis throughout the life of the I...

  3. 76 FR 27898 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... greenhouse gas (GHG) Prevention of Significant Deterioration (PSD) permitting provisions as promulgated on June 3, 2010 in the Tailoring Rule. The SIP revision modifies Virginia's PSD program to [[Page 27899... become subject to Virginia's PSD permitting requirements for their GHG emissions. EPA is approving...

  4. 77 FR 36442 - Approval and Promulgation of Air Quality Implementation Plans; Michigan; PSD Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... Promulgation of Air Quality Implementation Plans; Michigan; PSD Regulations AGENCY: Environmental Protection... Significant Deterioration (PSD) construction permit program of State of Michigan's State Implementation Plan (SIP) to meet the Clean Air Act (CAA) requirements for PSD in Class I Areas attaining the National...

  5. 76 FR 9658 - Approval and Promulgation of Implementation Plans; Kansas: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... greenhouse gas (GHG) under Kansas's New Source Review (NSR) Prevention of Significant Deterioration (PSD) program. First, the SIP revision provides the State of Kansas with authority to issue PSD permits... stationary sources and modification projects become subject to Kansas's PSD permitting requirements for their...

  6. 75 FR 81863 - Approval and Promulgation of Implementation Plans; Alabama: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... Deterioration (PSD) program. Specifically, the SIP revision establishes appropriate emission thresholds for determining which new stationary sources and modification projects become subject to Alabama's PSD permitting requirements for their GHG emissions. The change is necessary because without it, on January 2, 2011, PSD...

  7. 75 FR 69909 - Approval and Promulgation of Implementation Plans; Texas; Emissions Banking and Trading of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Promulgation of Implementation Plans; Texas; Emissions Banking and Trading of Allowances Program AGENCY... four revisions to the Texas State Implementation Plan (SIP) that create and amend the Emissions Banking... reached via electronic mail at [email protected] . SUPPLEMENTARY INFORMATION: In the final rules section...

  8. 78 FR 34966 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Removal of Gasoline...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... substitute equivalent emissions reductions to compensate for any change to a SIP-approved program, as long as actual emissions in the air are not increased. ``Equivalent'' emissions reductions mean reductions which... show that compensating emissions reductions are equivalent, modeling or adequate justification must be...

  9. 46 CFR 8.520 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Application. 8.520 Section 8.520 Shipping COAST GUARD... Streamlined Inspection Program § 8.520 Application. To apply for SIP enrollment, a company will submit an application, in writing, to the cognizant OCMI. The application must contain the following: (a) A statement...

  10. 78 FR 52857 - Approval and Promulgation of Implementation Plans; State of Iowa

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Health Rules and Regulations, Chapter V, Air Pollution. The revisions reflect updates to the Iowa..., Chapter V, ``Air Pollution,'' as a revision to the SIP. In order for the local program's ``Air Pollution..., ``Air Pollution.'' The local agency routinely revises its ``Air Pollution'' regulations to be consistent...

  11. 78 FR 25717 - Applications for New Awards; Strengthening Institutions Program (SIP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... use of time, staff, money, or other resources while improving student learning or other educational... migrant, or who have disabilities. Open educational resources (OER) means teaching, learning, and research... awards for individual development grants in rank order from the funding slate according to the average...

  12. 78 FR 30829 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Air Quality Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Promulgation of Air Quality Implementation Plans; Illinois; Air Quality Standards Revision AGENCY... the Illinois State Implementation Plan (SIP) to reflect current national ambient air quality standards...) 692-2450. 4. Mail: Pamela Blakley, Chief, Control Strategies Section, Air Programs Branch (AR-18J), U...

  13. 76 FR 23196 - Approval and Promulgation of Air Quality Implementation Plans; IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... Promulgation of Air Quality Implementation Plans; IL AGENCY: Environmental Protection Agency (EPA). ACTION... VOC for purposes of preparing SIPs to attain the national ambient air quality standard for ozone under... Section, Air Programs Branch (AR-18J), U.S. Environmental Protection Agency, 77 West Jackson Boulevard...

  14. Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance.

    PubMed

    Azar, Nabil J; Lagrange, Andre H; Wang, Lily; Song, Yanna; Abou-Khalil, Bassel W

    2010-05-01

    A drug holiday seems to produce seizure interval prolongation (SIP) after reinstitution of antiepileptic drugs (AEDs). This effect was demonstrated mainly with carbamazepine. We evaluated SIP with newer AEDs and tested the relationship of SIP to history of AED tolerance. We prospectively studied patients with refractory epilepsy admitted to the Vanderbilt epilepsy monitoring unit (EMU) over a period of 12 months. We included only patients on levetiracetam, lamotrigine, or oxcarbazepine who had their AEDs withdrawn on admission and reinstituted without change upon discharge. We defined SIP as the interval from EMU discharge to first seizure minus the interval between the last two seizures before EMU admission. A total of 43 patients completed the study; 15 were on monotherapy. SIP was greater than zero in this patient group (p < 0.0001), with a mean prolongation of 19.4 +/- 28.0 days. The average SIP was higher (p = 0.01) in patients on monotherapy (29.7 +/- 23.8 days) than patients on polytherapy (13.9 +/- 29.0 days). SIP tended to be greater in patients with a prior history of AED tolerance (25.7 +/- 36.8 days) compared to patient with no prior history of AED tolerance (14.0 +/- 16.3 days). SIP does occur after brief AED withdrawal. This effect is greater in patients on monotherapy and tends to be larger in patients with a history of AED tolerance. The SIP effect may be related to the phenomenon of tolerance, clinically seen as resistance to AED therapeutic effect.

  15. Do we act upon what we see? Direct effects of alcohol cues in movies on young adults' alcohol drinking.

    PubMed

    Koordeman, Renske; Kuntsche, Emmanuel; Anschutz, Doeschka J; van Baaren, Rick B; Engels, Rutger C M E

    2011-01-01

    Ample survey research has shown that alcohol portrayals in movies affect the development of alcohol consumption in youth. Hence, there is preliminary evidence that alcohol portrayals in movies also directly influence viewers' drinking of alcohol while watching movies. One process that might account for these direct effects is imitation. The present study therefore examined whether young people imitate actors sipping alcohol on screen. We observed sipping behaviours of 79 young adults (ages 18-25) watching a 60-min movie clip, 'What Happens in Vegas', in a semi-naturalistic home setting. Each of the 79 participants was exposed to 25 alcohol cues. Two-level logistic regression analyses were used to analyse whether participants in general imitated actors' sipping during this clip. In addition, we applied proportional hazard models in a survival analysis framework (Cox regression) to test whether there was a difference in imitation of the cues between male and female participants, and to test whether the timing of the actors' sipping throughout the movie played a role. The findings showed that participants were more likely to sip in accordance with the actors' sipping than without such a cue. Further, we found that men were more likely to imitate actors' sipping than females and that participants tended to respond to actors' sipping at the beginning of the movie rather than at the end. Exposure to actors sipping alcohol in a movie seems to have an immediate impact on the drinking behaviour of viewers, via the mechanism of imitation.

  16. 76 FR 28437 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... announced below concerns ``Validation of Self-Reported Sleep Surveillance Measures, SIP11-047, Panel E..., discussion, and evaluation of ``Validation of Self-Reported Sleep Surveillance Measures, SIP11-047, Panel E...

  17. Applying process mapping and analysis as a quality improvement strategy to increase the adoption of fruit, vegetable, and water breaks in Australian primary schools.

    PubMed

    Biggs, Janice S; Farrell, Louise; Lawrence, Glenda; Johnson, Julie K

    2014-03-01

    Over the past decade, public health policy in Australia has prioritized the prevention and control of obesity and invested in programs that promote healthy eating-related behaviors, which includes increasing fruit and vegetable consumption in children. This article reports on a study that used process mapping and analysis as a quality improvement strategy to improve the delivery of a nutrition primary prevention program delivered in primary schools in New South Wales, Australia. Crunch&Sip® has been delivered since 2008. To date, adoption is low with only 25% of schools implementing the program. We investigated the cause of low adoption and propose actions to increase school participation. We conducted semistructured interviews with key stakeholders and analyzed the process of delivering Crunch&Sip to schools. Interviews and process mapping and analysis identified a number of barriers to schools adopting the program. The analyses identified the need to simplify and streamline the process of delivering the program to schools and introduce monitoring and feedback loops to track ongoing participation. The combination of stakeholder interviews and process mapping and analysis provided important practical solutions to improving program delivery and also contributed to building an understanding of factors that help and hinder program adoption. The insight provided by this analysis helped identify usable routine measures of adoption, which were an improvement over those used in the existing program plan. This study contributed toward improving the quality and efficiency of delivering a health promoting program to work toward achieving healthy eating behaviors in children.

  18. Louisiana SIP: LAC 33:III Ch 23 Subchap B, §2303--Aluminum Plants, §2303 Standards for Horizontal Stud Soderberg Primary Aluminum Plants and Prebake Primary Aluminum Plants; SIP effective 1989-05-08 (LAc49) to 2011-08-03 (LAad34 - Revised)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch 23 Subchap B, §2303--Aluminum Plants, §2303 Standards for Horizontal Stud Soderberg Primary Aluminum Plants and Prebake Primary Aluminum Plants; SIP effective 1989-05-08 (LAc49) to 2011-08-03 (LAad34 - Revised)

  19. SipA Activation of Caspase-3 Is a Decisive Mediator of Host Cell Survival at Early Stages of Salmonella enterica Serovar Typhimurium Infection

    PubMed Central

    McIntosh, Anne; Meikle, Lynsey M.; Ormsby, Michael J.; McCormick, Beth A.; Christie, John M.; Brewer, James M.; Roberts, Mark

    2017-01-01

    ABSTRACT Salmonella invasion protein A (SipA) is a dual-function effector protein that plays roles in both actin polymerization and caspase-3 activation in intestinal epithelial cells. To date its function in other cell types has remained largely unknown despite its expression in multiple cell types and its extracellular secretion during infection. Here we show that in macrophages SipA induces increased caspase-3 activation early in infection. This activation required a threshold level of SipA linked to multiplicity of infection and may be a limiting factor controlling bacterial numbers in infected macrophages. In polymorphonuclear leukocytes, SipA or other Salmonella pathogenicity island 1 effectors had no effect on induction of caspase-3 activation either alone or in the presence of whole bacteria. Tagging of SipA with the small fluorescent phiLOV tag, which can pass through the type three secretion system, allowed visualization and quantification of caspase-3 activation by SipA-phiLOV in macrophages. Additionally, SipA-phiLOV activation of caspase-3 could be tracked in the intestine through multiphoton laser scanning microscopy in an ex vivo intestinal model. This allowed visualization of areas where the intestinal epithelium had been compromised and demonstrated the potential use of this fluorescent tag for in vivo tracking of individual effectors. PMID:28630067

  20. Infrastructure State Implementation Plan (SIP) Requirements and Guidance

    EPA Pesticide Factsheets

    The Clean Air Act requires states to submit SIPs that implement, maintain, and enforce a new or revised national ambient air quality standard (NAAQS) within 3 years of EPA issuing the standard. The Infrastructure SIP is required for all states.

  1. Thermoelectric energy converter for generation of electricity from low-grade heat

    DOEpatents

    Jayadev, T.S.; Benson, D.K.

    1980-05-27

    A thermoelectric energy conversion device which includes a plurality of thermoelectric elements is described. A hot liquid is supplied to one side of each element and a cold liquid is supplied to the other side of each element. The thermoelectric generator may be utilized to produce power from low-grade heat sources such as ocean thermal gradients, solar ponds, and low-grade geothermal resources. (WHK)

  2. Writing My Way to My Future | Poster

    Cancer.gov

    By Nathalie Walker, Guest Writer Editor’s note: This article is the second in a series describing one student’s perspective on her experiences as a Werner H. Kirsten student intern. “The future depends on what you do today.” Those wise words were spoken by Mahatma Gandhi. Before I started my Werner H. Kirsten (WHK) student internship, I did not know what I know now. I only

  3. Spectral Induced Polarization approaches to characterize reactive transport parameters and processes

    NASA Astrophysics Data System (ADS)

    Schmutz, M.; Franceschi, M.; Revil, A.; Peruzzo, L.; Maury, T.; Vaudelet, P.; Ghorbani, A.; Hubbard, S. S.

    2017-12-01

    For almost a decade, geophysical methods have explored the potential for characterization of reactive transport parameters and processes relevant to hydrogeology, contaminant remediation, and oil and gas applications. Spectral Induced Polarization (SIP) methods show particular promise in this endeavour, given the sensitivity of the SIP signature to geological material electrical double layer properties and the critical role of the electrical double layer on reactive transport processes, such as adsorption. In this presentation, we discuss results from several recent studies that have been performed to quantify the value of SIP parameters for characterizing reactive transport parameters. The advances have been realized through performing experimental studies and interpreting their responses using theoretical and numerical approaches. We describe a series of controlled experimental studies that have been performed to quantify the SIP responses to variations in grain size and specific surface area, pore fluid geochemistry, and other factors. We also model chemical reactions at the interface fluid/matrix linked to part of our experimental data set. For some examples, both geochemical modelling and measurements are integrated into a SIP physico-chemical based model. Our studies indicate both the potential of and the opportunity for using SIP to estimate reactive transport parameters. In case of well sorted granulometry of the samples, we find that the grain size characterization (as well as the permeabililty for some specific examples) value can be estimated using SIP. We show that SIP is sensitive to physico-chemical conditions at the fluid/mineral interface, including the different pore fluid dissolved ions (Na+, Cu2+, Zn2+, Pb2+) due to their different adsorption behavior. We also showed the relevance of our approach to characterize the fluid/matrix interaction for various organic contents (wetting and non-wetting oils). We also discuss early efforts to jointly interpret SIP and other information for improved estimation, approaches to use SIP information to constrain mechanistic flow and transport models, and the potential to apply some of the approaches to field scale applications.

  4. S100A6 Protein Negatively Regulates CacyBP/SIP-Mediated Inhibition of Gastric Cancer Cell Proliferation and Tumorigenesis

    PubMed Central

    Zhang, Kun; Liang, Jie; Chuai, Yucai; Li, Yuan; Wang, Xiaoming

    2012-01-01

    Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our laboratory. Importantly, the effects of S100 proteins on the biological behavior of CacyBP/SIP in gastric cancer remain unclear. Herein, we report the construction of eukaryotic expression vectors for wild-type CacyBP/SIP and a truncated mutant lacking the S100 protein binding domain (CacyBP/SIPΔS100). The expressions of the wild-type and truncated recombinant proteins were demonstrated by transfection of MKN45 gastric cancer cells. Co-immunoprecipitation assays demonstrated interaction between S100A6 and wild-type CacyBP/SIP in MKN45 cells. Removal of the S100 protein binding domain dramatically reduced the affinity of CacyBP/SIP for S100 proteins as indicated by reduced co-immunoprecipitation of S100A6 by CacyBP/SIPΔS100. The MTT assay, FACS assay, clonogenic assay and tumor xenograft experiment were performed to assess the effect of CacyBP/SIP on cell growth and tumorigenesis in vitro and in vivo. Overexpression of CacyBP/SIP inhibited the proliferation and tumorigenesis of MKN45 gastric cancer cells; the proliferation and tumorigenesis rates were even further reduced by the expression of CacyBP/SIPΔS100. We also showed that S100 proteins negatively regulate CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation, through an effect on β-catenin protein expression and transcriptional activation of Tcf/LEF. Although the underlying mechanism of action requires further investigation, this study provides new insight into the interaction between S100 proteins and CacyBP/SIP, which might enrich our knowledge of S100 proteins and be helpful for our understanding of the development of gastric cancer. PMID:22295074

  5. Social Information Processing and Cluster B Personality Pathology among Clinic-Referred Adolescents.

    PubMed

    Hessels, Christel; van Aken, Marcel A G; Orobio de Castro, Bram; Laceulle, Odilia M; van Voorst, Guus

    2016-01-01

    This study investigated relations between personality pathology and mentalizing capacities reflected in social information processing (SIP) of adolescents. 96 adolescent outpatients completed a structured interview regarding SIP. Their clinicians completed a checklist based on DSM-IV, assessing severity of personality pathology. Significant relations were found between the severity of personality pathology and SIP: the more severe the personality pathology, the higher the intensity of reported emotions, the more likely adolescents were to choose inadequate coping strategies and aggressive reactions in social situations, and the more positively they evaluated aggressive reactions. Severity of traits of antisocial (ASPD) and borderline personality disorder (BPD) had unique associations with distinctive SIP variables: ASPD being more related to inadequate coping strategies, less reflection on other's motives and aggressive responses, and BPD being more related to avoidant or prosocial responses and in particular to memories of frustrating events. This study provides evidence for difficulties in SIP among adolescents with more severe personality pathology, suggesting that the steps in the SIP model can be used to operationalize mentalizing problems. The results seem to paint a picture of ASPD and BPD having a shared background, but their own specific problems concerning SIP. © 2016 S. Karger AG, Basel.

  6. Louisiana SIP: LAC 33:III Ch. 5 Section 509. Prevention of Significant Deterioration; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) and 1991-07-01 (LAc57) and 1996-12-16 (LAc69) to 2011-08-17 (LAd36 - Revised)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 5 Section 509. Prevention of Significant Deterioration; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) and 1991-07-01 (LAc57) and 1996-12-16 (LAc69) to 2011-08-17 (LAd36 - Revised)

  7. Louisiana SIP: LAC 33:III Ch 61 Subchap A, §6121 to § 6131--Method 43 - Capture Efficiency Test Procedures; SIP effective 1994-06-06 (LAc60) to to 2011-08-03 (LAd34 - Moved to Chap 21 Subchap N §§ 2155-2160 and revised)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch 61 Subchap A, §6121 to § 6131--Method 43 - Capture Efficiency Test Procedures; SIP effective 1994-06-06 (LAc60) to to 2011-08-03 (LAd34 - Moved to Chap 21 Subchap N §§ 2155-2160 and revised)

  8. Louisiana SIP: LAC 33:III Ch. 7 - Table 2 - Ambient Air--Methods of Contaminant Measurements; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Moved to Section 711 and revised [adds PM-2.5])

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 7 - Table 2 - Ambient Air--Methods of Contaminant Measurements; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Moved to Section 711 and revised [adds PM-2.5])

  9. Louisiana SIP: LAC 33:III Ch. 7 Section 709. Measurement of Concentrations PM10, SO2, Carbon Monoxide, Atmospheric Oxidants, Nitrogen Oxides, and Lead; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Revised)

    EPA Pesticide Factsheets

    Louisiana SIP: LAC 33:III Ch. 7 Section 709. Measurement of Concentrations PM10, SO2, Carbon Monoxide, Atmospheric Oxidants, Nitrogen Oxides, and Lead; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Revised)

  10. The Short Inventory of Problems – Revised (SIP-R): Psychometric properties within a large, diverse sample of substance use disorder treatment seekers

    PubMed Central

    Kiluk, Brian D.; Dreifuss, Jessica A.; Weiss, Roger D.; Morgenstern, Jon; Carroll, Kathleen M.

    2012-01-01

    Assessment of the adverse consequences of substance use serves an important function in both clinical and research settings, yet there is no universally agreed upon measure of consequences relevant to multiple types of substance use disorders. One of the most commonly used measures, the Short Inventory of Problems (SIP), has been adapted and evaluated in several specific populations, but evidence of its reliability and validity across broader samples of persons with substance use disorders is needed. This study evaluated the psychometric properties of a revised version of the SIP (SIP-R) in a large combined sample of alcohol and drug use disorder treatment-seekers, with participants pooled from two national, multisite randomized clinical trials. A total of 886 participants across 10 outpatient treatment facilities completed a common assessment battery that included the SIP-R, Addiction Severity Index (ASI), University of Rhode Island Change Assessment (URICA), HIV Risk Behavior Scale (HRBS), and a substance use calendar. Results supported the SIP-R’s internal reliability (α=.95). Confirmatory factor analysis demonstrated that the hypothesized 5-factor model with one higher-order factor produced the best fit. Convergent validity was evident through the SIP-R’s correlation with several composite scores from the ASI and the URICA, and analyses supported its conceptual distinction from quantity indices of drug/alcohol use. The SIP-R also demonstrated an ability to predict treatment retention, with higher scores associated with poorer retention. These results provide support for the SIP-R’s psychometric properties as a measure of consequences across a broad sample of treatment-seeking drug and alcohol users. PMID:22642856

  11. A Semi-Infinite Programming based algorithm for determining T-optimum designs for model discrimination

    PubMed Central

    Duarte, Belmiro P.M.; Wong, Weng Kee; Atkinson, Anthony C.

    2016-01-01

    T-optimum designs for model discrimination are notoriously difficult to find because of the computational difficulty involved in solving an optimization problem that involves two layers of optimization. Only a handful of analytical T-optimal designs are available for the simplest problems; the rest in the literature are found using specialized numerical procedures for a specific problem. We propose a potentially more systematic and general way for finding T-optimal designs using a Semi-Infinite Programming (SIP) approach. The strategy requires that we first reformulate the original minimax or maximin optimization problem into an equivalent semi-infinite program and solve it using an exchange-based method where lower and upper bounds produced by solving the outer and the inner programs, are iterated to convergence. A global Nonlinear Programming (NLP) solver is used to handle the subproblems, thus finding the optimal design and the least favorable parametric configuration that minimizes the residual sum of squares from the alternative or test models. We also use a nonlinear program to check the global optimality of the SIP-generated design and automate the construction of globally optimal designs. The algorithm is successfully used to produce results that coincide with several T-optimal designs reported in the literature for various types of model discrimination problems with normally distributed errors. However, our method is more general, merely requiring that the parameters of the model be estimated by a numerical optimization. PMID:27330230

  12. A Semi-Infinite Programming based algorithm for determining T-optimum designs for model discrimination.

    PubMed

    Duarte, Belmiro P M; Wong, Weng Kee; Atkinson, Anthony C

    2015-03-01

    T-optimum designs for model discrimination are notoriously difficult to find because of the computational difficulty involved in solving an optimization problem that involves two layers of optimization. Only a handful of analytical T-optimal designs are available for the simplest problems; the rest in the literature are found using specialized numerical procedures for a specific problem. We propose a potentially more systematic and general way for finding T-optimal designs using a Semi-Infinite Programming (SIP) approach. The strategy requires that we first reformulate the original minimax or maximin optimization problem into an equivalent semi-infinite program and solve it using an exchange-based method where lower and upper bounds produced by solving the outer and the inner programs, are iterated to convergence. A global Nonlinear Programming (NLP) solver is used to handle the subproblems, thus finding the optimal design and the least favorable parametric configuration that minimizes the residual sum of squares from the alternative or test models. We also use a nonlinear program to check the global optimality of the SIP-generated design and automate the construction of globally optimal designs. The algorithm is successfully used to produce results that coincide with several T-optimal designs reported in the literature for various types of model discrimination problems with normally distributed errors. However, our method is more general, merely requiring that the parameters of the model be estimated by a numerical optimization.

  13. The potential role of CacyBP/SIP in tumorigenesis.

    PubMed

    Ning, Xiaoxuan; Chen, Yang; Wang, Xiaosu; Li, Qiaoneng; Sun, Shiren

    2016-08-01

    Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. This 30 kDa protein includes three domains and is involved in cell proliferation, differentiation, cytoskeletal rearrangement, and transcriptional regulation via binding to various proteins. Studies have also shown that the CacyBP/SIP is a critical protein in tumorigenesis. But, its promotion or suppression of cancer progression may depend on the cell type. In this review, the biological characteristics and target proteins of CacyBP/SIP have been described. Moreover, the exact role of CacyBP/SIP in various cancers is discussed.

  14. Seismo-Ionospheric Precursor in the GIM TEC of the 24 August 2014 M6 Napa Earthquake

    NASA Astrophysics Data System (ADS)

    Wu, T. Y.; Liu, T. J. Y.; Liu, J. Y.

    2015-12-01

    This study examines seismo-ionospheric precursors (SIPs) in the global ionosphere map (GIM) of the total electron content (TEC) associated with the 24 August 2014 M6 South Napa earthquake and statistical evidence of SIPs of the GPS TEC in western USA during 2000-2014. The temporal SIP in the GIM TEC around the epicenter significantly decreasing (negative anomaly) on 22 August. To discriminate the global effect, such as solar flares, magnetic storms, etc., and the local effect, such as earthquakes, 5183 lattices on the GIM are employed to conduct a global search of the SIP distribution. Anomalies of both GIM TEC and associated gradients specifically and continuously appearing over the epicenter suggest that the SIP relate to the 2014 South Napa earthquake. A simulation is further carried out to produce the SIP in GIM TEC before the earthquake. Results indicate that the eastward electric field generated over the epicenter area during the earthquake preparation period to be essential.

  15. Heterologous Protein Secretion in Lactobacilli with Modified pSIP Vectors

    PubMed Central

    Karlskås, Ingrid Lea; Maudal, Kristina; Axelsson, Lars; Rud, Ida; Eijsink, Vincent G. H.; Mathiesen, Geir

    2014-01-01

    We describe new variants of the modular pSIP-vectors for inducible gene expression and protein secretion in lactobacilli. The basic functionality of the pSIP system was tested in Lactobacillus strains representing 14 species using pSIP411, which harbors the broad-host-range Lactococcus lactis SH71rep replicon and a β-glucuronidase encoding reporter gene. In 10 species, the inducible gene expression system was functional. Based on these results, three pSIP vectors with different signal peptides were modified by replacing their narrow-host-range L. plantarum 256rep replicon with SH71rep and transformed into strains of five different species of Lactobacillus. All recombinant strains secreted the target protein NucA, albeit with varying production levels and secretion efficiencies. The Lp_3050 derived signal peptide generally resulted in the highest levels of secreted NucA. These modified pSIP vectors are useful tools for engineering a wide variety of Lactobacillus species. PMID:24614815

  16. Molecular Analysis of Phr Peptide Processing in Bacillus subtilis†

    PubMed Central

    Stephenson, Sophie; Mueller, Christian; Jiang, Min; Perego, Marta

    2003-01-01

    In Bacillus subtilis, an export-import pathway regulates production of the Phr pentapeptide inhibitors of Rap proteins. Processing of the Phr precursor proteins into the active pentapeptide form is a key event in the initiation of sporulation and competence development. The PhrA (ARNQT) and PhrE (SRNVT) peptides inhibit the RapA and RapE phosphatases, respectively, whose activity is directed toward the Spo0F∼P intermediate response regulator of the sporulation phosphorelay. The PhrC (ERGMT) peptide inhibits the RapC protein acting on the ComA response regulator for competence with regard to DNA transformation. The structural organization of PhrA, PhrE, and PhrC suggested a role for type I signal peptidases in the processing of the Phr preinhibitor, encoded by the phr genes, into the proinhibitor form. The proinhibitor was then postulated to be cleaved to the active pentapeptide inhibitor by an additional enzyme. In this report, we provide evidence that Phr preinhibitor proteins are subject to only one processing event at the peptide bond on the amino-terminal end of the pentapeptide. This processing event is most likely independent of type I signal peptidase activity. In vivo and in vitro analyses indicate that none of the five signal peptidases of B. subtilis (SipS, SipT, SipU, SipV, and SipW) are indispensable for Phr processing. However, we show that SipV and SipT have a previously undescribed role in sporulation, competence, and cell growth. PMID:12897006

  17. Molecular analysis of Phr peptide processing in Bacillus subtilis.

    PubMed

    Stephenson, Sophie; Mueller, Christian; Jiang, Min; Perego, Marta

    2003-08-01

    In Bacillus subtilis, an export-import pathway regulates production of the Phr pentapeptide inhibitors of Rap proteins. Processing of the Phr precursor proteins into the active pentapeptide form is a key event in the initiation of sporulation and competence development. The PhrA (ARNQT) and PhrE (SRNVT) peptides inhibit the RapA and RapE phosphatases, respectively, whose activity is directed toward the Spo0F approximately P intermediate response regulator of the sporulation phosphorelay. The PhrC (ERGMT) peptide inhibits the RapC protein acting on the ComA response regulator for competence with regard to DNA transformation. The structural organization of PhrA, PhrE, and PhrC suggested a role for type I signal peptidases in the processing of the Phr preinhibitor, encoded by the phr genes, into the proinhibitor form. The proinhibitor was then postulated to be cleaved to the active pentapeptide inhibitor by an additional enzyme. In this report, we provide evidence that Phr preinhibitor proteins are subject to only one processing event at the peptide bond on the amino-terminal end of the pentapeptide. This processing event is most likely independent of type I signal peptidase activity. In vivo and in vitro analyses indicate that none of the five signal peptidases of B. subtilis (SipS, SipT, SipU, SipV, and SipW) are indispensable for Phr processing. However, we show that SipV and SipT have a previously undescribed role in sporulation, competence, and cell growth.

  18. Kids SIP smartER: A Feasibility Study to Reduce Sugar-Sweetened Beverage Consumption Among Middle School Youth in Central Appalachia.

    PubMed

    Lane, Hannah; Porter, Kathleen J; Hecht, Erin; Harris, Priscilla; Kraak, Vivica; Zoellner, Jamie

    2017-01-01

    To test the feasibility of Kids SIP smartER, a school-based intervention to reduce consumption of sugar-sweetened beverages (SSBs). Matched-contact randomized crossover study with mixed-methods analysis. One middle school in rural, Appalachian Virginia. Seventy-four sixth and seventh graders (5 classrooms) received Kids SIP smartER in random order over 2 intervention periods. Feasibility outcomes were assessed among 2 teachers. Kids SIP smartER consisted of 6 lessons grounded in the Theory of Planned Behavior, media literacy, and public health literacy and aimed to improve individual SSB behaviors and understanding of media literacy and prevalent regional disparities. The matched-contact intervention promoted physical activity. Beverage Intake Questionnaire-15 (SSB consumption), validated theory questionnaires, feasibility questionnaires (student and teacher), student focus groups, teacher interviews, and process data (eg, attendance). Repeated measures analysis of variances across 3 time points, descriptive statistics, and deductive analysis of qualitative data. During the first intervention period, students receiving Kids SIP smartER (n = 43) significantly reduced SSBs by 11 ounces/day ( P = .01) and improved media ( P < .001) and public health literacy ( P < .01) understanding; however, only media literacy showed between-group differences ( P < .01). Students and teachers found Kids SIP smartER acceptable, in-demand, practical, and implementable within existing resources. Kids SIP smartER is feasible in an underresourced, rural school setting. Results will inform further development and large-scale testing of Kids SIP smartER to reduce SSBs among rural adolescents.

  19. Multiple-sip temporal dominance of sensations associated with acceptance test: a study on special beers.

    PubMed

    Corrêa Simioni, Síntia Carla; Ribeiro, Michele Nayara; de Souza, Vanessa Rios; Nunes, Cleiton Antônio; Pinheiro, Ana Carla Marques

    2018-03-01

    In this study, we proposed the use of a multiple-sip temporal dominance of sensations (TDS) test alongside with an acceptance test over repeated consumption for the analysis of special beers, with the aim of contributing to a deeper understanding of consumer behavior regarding temporal descriptions and sensory acceptance. Consumers of special beers sequentially evaluated six sips of a particular type of beer by TDS analysis and an acceptance test was performed for each sip. Four different kinds of specialty beers were evaluated [Bohemian Pilsner (BP), Witbier (WB), Belgian Strong Ale Dubbel (BD), and Russian Imperial Stout (RS)]. In general, the descriptive profile of beers varied temporally, i.e., there was an increased dominance of bitterness and a decreased dominance of fruity, floral, toffee, and coffee attributes. Concurrently, a reduction in sensory acceptance with an increased number of sips, especially the last sip, was observed in two kinds of beers that possessed a strong flavor, BD and RS. BP and WB presented smooth attributes and low notable characteristics, which could have contributed to the maintenance of the acceptance grades as the number of sips increased. The combination of TDS and acceptance over repeated sips can be useful for obtaining detailed descriptions of products that are closer to real time consumption by consumers, and thus aids in ensuring good product performance once released. The information obtained can also help product development scientists to fine-tune product formulations and ensure acceptability.

  20. 76 FR 15 - Approval and Promulgation of Implementation Plans; Texas; Emissions Banking and Trading of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... Promulgation of Implementation Plans; Texas; Emissions Banking and Trading of Allowances Program AGENCY... to the Texas State Implementation Plan (SIP) that create and amend the Emissions Banking and Trading... hard copy at the Air Planning Section (6PD-L), Environmental Protection Agency, 1445 Ross Avenue, Suite...

  1. 77 FR 28261 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Nonattainment New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... business information (CBI) or other information whose disclosure is restricted by statute. Certain other... www.regulations.gov or in hard copy for public inspection during normal business hours at the Air.... The history of this SIP, the NSR Reform Program, and South Coast Air Quality Management District v...

  2. 78 FR 5346 - Approval and Promulgation of Air Quality Implementation Plans; Massachusetts and New Hampshire...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ...-FRL-9754-7] Approval and Promulgation of Air Quality Implementation Plans; Massachusetts and New... (EPA). ACTION: Proposed rule. SUMMARY: EPA is proposing to approve State Implementation Plan (SIP... repair network for an on-board diagnostic (OBD2) testing program for model year 1996 and newer vehicles...

  3. IDENTIFICATION AND CHARACTERIZATION OF FIVE NON- TRADITIONAL SOURCE CATEGORIES: CATASTROPHIC/ACCIDENTAL RELEASES, VEHICLE REPAIR FACILITIES, RECYCLING, PESTICIDE APPLICATION, AND AGRICULTURAL OPERATIONS

    EPA Science Inventory

    The report gives results of work that is part of EPA's program to identify and characterize emissions sources not currently accounted for by either the existing Aerometric Information Retrieval System (AIRS) or State Implementation Plan (SIP) area source methodologies and to deve...

  4. 78 FR 37457 - Approval and Promulgation of Implementation Plans; State of Missouri; Infrastructure SIP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... ensure that the structural components of each state's air quality management program are adequate to meet... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R07-OAR-2013-0208; FRL-9825-7] Approval and... Fine Particulate Matter National Ambient Air Quality Standards AGENCY: Environmental Protection Agency...

  5. 77 FR 64734 - Approval and Promulgation of Implementation Plans; North Dakota: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Permitting Authority and Tailoring Rule; PM 2.5 NSR Implementation Rule AGENCY: Environmental Protection... Implementation Plan (SIP) relating to regulation of Greenhouse Gases (GHGs) and fine particulate matter (PM 2.5... Tailoring Final Rule'' and the final rule for ``Implementation of the New Source Review (NSR) Program for PM...

  6. 77 FR 30214 - Approval and Promulgation of Air Quality Implementation Plans; Rhode Island; Regional Haze

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... Promulgation of Air Quality Implementation Plans; Rhode Island; Regional Haze AGENCY: Environmental Protection... Implementation Plan (SIP) that addresses regional haze for the first planning period from 2008 through 2018. The... geographic area (also referred to as the ``regional haze program''). DATES: Effective Date: This rule is...

  7. 77 FR 16937 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Regional Haze State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... Promulgation of Air Quality Implementation Plans; West Virginia; Regional Haze State Implementation Plan AGENCY... limited disapproval of West Virginia's Regional Haze State Implementation Plan (SIP) revision. EPA is... mandatory Class I areas through a regional haze program. EPA is also approving this revision as meeting the...

  8. 77 FR 5191 - Approval and Promulgation of Air Quality Implementation Plans; District of Columbia; Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... Promulgation of Air Quality Implementation Plans; District of Columbia; Regional Haze State Implementation Plan... of Columbia Regional Haze Plan, a revision to the District of Columbia State Implementation Plan (SIP... existing anthropogenic impairment of visibility in mandatory Class I areas through a regional haze program...

  9. 40 CFR 52.881 - PM10 State implementation plan development in group II areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... development in group II areas. 52.881 Section 52.881 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kansas § 52.881 PM10 State implementation plan development in group II areas. The state has submitted a committal SIP for...

  10. 40 CFR 52.881 - PM10 State implementation plan development in group II areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... development in group II areas. 52.881 Section 52.881 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kansas § 52.881 PM10 State implementation plan development in group II areas. The state has submitted a committal SIP for...

  11. 40 CFR 52.881 - PM10 State implementation plan development in group II areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... development in group II areas. 52.881 Section 52.881 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kansas § 52.881 PM10 State implementation plan development in group II areas. The state has submitted a committal SIP for...

  12. 40 CFR 52.881 - PM10 State implementation plan development in group II areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... development in group II areas. 52.881 Section 52.881 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kansas § 52.881 PM10 State implementation plan development in group II areas. The state has submitted a committal SIP for...

  13. 40 CFR 52.881 - PM10 State implementation plan development in group II areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... development in group II areas. 52.881 Section 52.881 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kansas § 52.881 PM10 State implementation plan development in group II areas. The state has submitted a committal SIP for...

  14. 76 FR 36450 - Approval and Promulgation of Air Quality Implementation Plans; State of Nevada; Regional Haze...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... Technology (BART) E. Long-Term Strategy (LTS) F. Coordination of the Regional Haze SIP and Reasonably... for 2018 2. Establishing the Reasonable Progress Goal 3. Interstate Consultation G. Long-Term Strategy... implementation of the regional haze program will require long-term coordination among states, Tribal governments...

  15. 77 FR 13238 - Partial Approval and Promulgation of Implementation Plans; Washington: Infrastructure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... from the Washington State Department of Ecology (Ecology) to demonstrate that the SIP meets the...; Chapter 43.21 RCW Department of Ecology; Chapter 34.05 RCW Administrative Procedure Act; Chapter 42.30 RCW...) which requires Ecology to provide for or conduct surveillance program that: monitors the quality of the...

  16. 40 CFR 52.1773 - Conditional approval.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Deterioration (PSD) infrastructure requirements for the 1997 annual and 2006 24-hour fine particulate matter... to the PM2.5 standard for their PSD program and committing to providing the necessary SIP revision to... PM2.5 Rule (including PM2.5 PSD Increment-SILs-SMC, as it relates to PM2.5 increments to meet the...

  17. 40 CFR 52.1773 - Conditional approval.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Deterioration (PSD) infrastructure requirements for the 1997 annual and 2006 24-hour fine particulate matter... to the PM2.5 standard for their PSD program and committing to providing the necessary SIP revision to... PM2.5 Rule (including PM2.5 PSD Increment-SILs-SMC, as it relates to PM2.5 increments to meet the...

  18. 77 FR 56124 - Approval and Promulgation of Air Quality Implementation Plans; Michigan; PSD and NSR Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Promulgation of Air Quality Implementation Plans; Michigan; PSD and NSR Regulations AGENCY: Environmental... the prevention of significant deterioration (PSD) construction permit program for the purpose of... approving Michigan's request to revise its SIP to add rule R. 336.2816 to be consistent with Federal PSD...

  19. 78 FR 16785 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Cleveland-Akron-Lorain and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... mobile source emissions for criteria pollutants and/or their precursors to address pollution from cars, trucks and other on-road vehicles. These mobile source SIP budgets are the portions of the total...(c) of the CAA, transportation plans, Transportation Improvement Programs (TIPs), and transportation...

  20. 77 FR 20577 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Central Indiana...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... demonstration SIP revisions) and maintenance plans include budgets of on-road mobile source emissions for... 62188). Under section 176(c) of the CAA, transportation plans, Transportation Improvement Programs (TIPs... margin. Table 4.1-A in the submittal demonstrates how mobile source emissions decline from the attainment...

  1. 77 FR 75384 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Delaware County (Muncie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ..., state and Federal agencies in determining whether transportation activities conform to the SIP as... reflected in MOBILE6.2. Under section 176(c) of the Clean Air Act (CAA), transportation plans, Transportation Improvement Programs (TIPs), and transportation projects must ``conform'' to (i.e., be consistent...

  2. 78 FR 45152 - Approval and Promulgation of Implementation Plans and Designation of Areas; North Carolina...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... available control measures (RACM), a reasonable further progress (RFP) plan, \\2\\ contingency measures, a..., contingency measures, and other planning SIP revisions related to attainment of the standard were suspended as...,'' Memorandum from G. T. Helms, Chief, Ozone/Carbon Monoxide Programs Branch, April 30, 1992; 3. ``Contingency...

  3. 40 CFR 51.122 - Emissions reporting requirements for SIP revisions relating to budgets for NOX emissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL... NOX emissions data as described in this section. (c) Each revision must provide for periodic reporting by the state of NOX emissions data to demonstrate whether the state's emissions are consistent with...

  4. 40 CFR 51.122 - Emissions reporting requirements for SIP revisions relating to budgets for NOX emissions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL... NOX emissions data as described in this section. (c) Each revision must provide for periodic reporting by the state of NOX emissions data to demonstrate whether the state's emissions are consistent with...

  5. 40 CFR 52.2522 - Approval status.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Federal regulatory SIP requirements for PSD applicable as of the August 31, 2011 SIP revision submission..., October 1, 2009, October 26, 2011, and February 17, 2012 which address the PSD-related requirements set... February 17, 2012 submitted to meet the PSD-related infrastructure SIP obligations set forth at CAA...

  6. Physical oceanographic data from the OTEC Punta Tuna, Puerto Rico Site, September 1979-June 1980

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frye, D.; Davison, A.; Leavitt, K.

    1981-01-01

    The first results of an oceanographic measurement program being conducted off the southeast corner of Puerto Rico are presented. The study site is a proposed OTEC site and is located about 20 km off Punta Tuna. The objectives of the measurement program are to document the physical oceanography of the site as related to the engineering and environmental factors involved in OTEC design and operation. Oceanographic measurements include: (1) a subsurface mooring instrumented with five current, temperature, and pressure recorders; and (2) quarterly hydrographic cruises to measure salinity, temperature, and depth profiles on a grid of 33 stations in themore » vicinity of the mooring site. The first cruise, conducted between 16 and 21 June 1980, included the initial mooring deployment and a CTD (conductivity, temperature, and depth) and XBT (expendable bathythermograph) survey. The CTD/XBT measurements are presented. Also included are results of in situ current, temperature, and pressure measurements made during two previous programs. In September 1979, Coastal Marine Research (CMR) deployed a mooring at approximately the same site as the present mooring. Results from three of these instruments are included. The Naval Underwater Systems Center deployed a mooring at this site in February 1979 and partial results from one instrument on this mooring are also presented. (WHK)« less

  7. New Developments in Developmental Research on Social Information Processing and Antisocial Behavior

    ERIC Educational Resources Information Center

    Fontaine, Reid Griffith

    2010-01-01

    The Special Section on developmental research on social information processing (SIP) and antisocial behavior is here introduced. Following a brief history of SIP theory, comments on several themes--measurement and assessment, attributional and interpretational style, response evaluation and decision, and the relation between emotion and SIP--that…

  8. 76 FR 28437 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial Review The meeting... Disease or Treated by Assisted Reproductive Technology, SIP11-048, Panel F,'' initial review In accordance...

  9. 75 FR 30410 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ..., Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider and Public Health... and Public Health Input for Vaccine Policy Decisions, SIP 10-036.'' Contact Person for More Information: Michelle Mathieson, Public Health Analyst, National Center for Chronic Disease and Health...

  10. School Inclusion Programmes (SIPS)

    ERIC Educational Resources Information Center

    Drossinou-Korea, Maria; Matousi, Dimitra; Panopoulos, Nikolaos; Paraskevopoulou, Aikaterini

    2016-01-01

    The purpose of this work was to understand the school inclusion programmes (SIPs) for students with special educational needs (SEN). The methodology was conducted in the field of special education (SE) and focuses on three case studies of students who was supported by SIPs. The Targeted, Individual, Structured, Inclusion Programme for students…

  11. Closed Conference Signalling Using the Session Initiation Protocol.

    ERIC Educational Resources Information Center

    Miladinovic, Igor; Stadler, Johannes

    2003-01-01

    Introduces an extension of the Session Initiation Protocol (SIP) for closed multiparty conferences; the extension expands SIP for discovery of participant identities in a conference, and ensures that each participant is notified before a new participant joins. Verifies this extension by applying it to two SIP conference models. Concludes with an…

  12. A Feasibility Study on the Geophysical Response to Nanoparticles in the Subsurface

    EPA Science Inventory

    The research presented herein aims to determine if a spectral induced polarization (SIP) response exists due to nanoparticles in a saturated sand matrix. If a SIP response is realized in such an experimental setting, then it is feasible that SIP may be capable of delineating nano...

  13. 40 CFR 52.1638 - Bernalillo County particulate matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) for Bernalillo County that contained commitments, from the Director of the Albuquerque Environmental... SIPs. The City of Albuquerque and Bernalillo County Air Quality Control Board adopted this SIP revision on November 9, 1988. (b) The Albuquerque Environmental Health Department has committed to comply with...

  14. 40 CFR 52.1638 - Bernalillo County particulate matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) for Bernalillo County that contained commitments, from the Director of the Albuquerque Environmental... SIPs. The City of Albuquerque and Bernalillo County Air Quality Control Board adopted this SIP revision on November 9, 1988. (b) The Albuquerque Environmental Health Department has committed to comply with...

  15. 40 CFR 52.1638 - Bernalillo County particulate matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) for Bernalillo County that contained commitments, from the Director of the Albuquerque Environmental... SIPs. The City of Albuquerque and Bernalillo County Air Quality Control Board adopted this SIP revision on November 9, 1988. (b) The Albuquerque Environmental Health Department has committed to comply with...

  16. Nationwide SIP Telephony Network Design to Prevent Congestion Caused by Disaster

    NASA Astrophysics Data System (ADS)

    Satoh, Daisuke; Ashitagawa, Kyoko

    We present a session initiation protocol (SIP) network design for a voice-over-IP network to prevent congestion caused by people calling friends and family after a disaster. The design increases the capacity of SIP servers in a network by using all of the SIP servers equally. It takes advantage of the fact that equipment for voice data packets is different from equipment for signaling packets in SIP networks. Furthermore, the design achieves simple routing on the basis of telephone numbers. We evaluated the performance of our design in preventing congestion through simulation. We showed that the proposed design has roughly 20 times more capacity, which is 57 times the normal load, than the conventional design if a disaster were to occur in Niigata Prefecture struck by the Chuetsu earthquake in 2004.

  17. 76 FR 52387 - Approval and Promulgation of Implementation Plans; New Mexico; Federal Implementation Plan for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ...EPA is disapproving a portion of the State Implementation Plan (SIP) revision received from the State of New Mexico on September 17, 2007, for the purpose of addressing the ``good neighbor'' requirements of section 110(a)(2)(D)(i) of the Clean Air Act (CAA or Act) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. In this action, EPA is disapproving the New Mexico Interstate Transport SIP provisions that address the requirement of section 110(a)(2)(D)(i)(II) that emissions from New Mexico sources do not interfere with measures required in the SIP of any other state under part C of the CAA to protect visibility. We have found that New Mexico sources, except the San Juan Generating Station, are sufficiently controlled to eliminate interference with the visibility programs of other states. EPA is promulgating a Federal Implementation Plan (FIP) to address this deficiency by implementing nitrogen oxides (NOX) and sulfur dioxide (SO2) emission limits necessary at the San Juan Generating Station (SJGS), to prevent such interference. EPA found in January 2009 that New Mexico had failed to submit a SIP addressing certain regional haze (RH) requirements, including the requirement for best available retrofit technology (BART). The Clean Air Act required EPA to promulgate a FIP to address RH requirements by January 2011. This FIP addresses the RH BART requirement for NOX for SJGS. In addition, EPA is implementing sulfuric acid (H2SO4) hourly emission limits at the SJGS, to minimize the contribution of this compound to visibility impairment. This action is being taken under section 110 and part C of the CAA.

  18. Student Intern Ben Freed Competes as Finalist in Intel STS Competition, Three Other Interns Named Semifinalists | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Werner H. Kirstin (WHK) student intern Ben Freed was one of 40 finalists to compete in the Intel Science Talent Search (STS) in Washington, DC, in March. “It was seven intense days of interacting with amazing judges and incredibly smart and interesting students. We met President Obama, and then the MIT astronomy lab named minor planets after each

  19. Solar heating system installed at Jackson, Tennessee. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1980-10-01

    The solar energy heating system installed at the Coca-Cola Bottling Works in Jackson, Tennessee is described. The system consists of 9480 square feet of Owens-Illinois evacuated tubular solar collectors with attached specular cylindrical reflectors and will provide space heating for the 70,000 square foot production building in the winter, and hot water for the bottle washing equipment the remainder of the year. Component specifications and engineering drawings are included. (WHK)

  20. A second gene for type I signal peptidase in Bradyrhizobium japonicum, sipF, is located near genes involved in RNA processing and cell division.

    PubMed

    Bairl, A; Müller, P

    1998-11-01

    The TnphoA-induced Bradyrhizobium japonicum mutant 184 shows slow growth and aberrant colonization of soybean nodules. Using a DNA fragment adjacent to the transposon insertion site as a probe, a 3.4-kb BglII fragment of B. japonicum 110spc4 DNA was identified and cloned. Sequence analysis indicated that two truncated ORFs and three complete ORFs were encoded on this fragment. A database search revealed homologies to several other prokaryotic proteins: PdxJ (an enzyme involved in vitamin B6 biosynthesis), AcpS (acyl carrier protein synthase), Lep or Sip (prokaryotic type I signal peptidase), RNase III (an endoribonuclease which processes double-stranded rRNA precursors and mRNA) and Era (a GTP-binding protein required for cell division). The mutation in strain 184 was found to lie within the signal peptidase gene, which was designated sipF. Therefore, sipF is located in a region that encodes gene products involved in posttranscriptional and posttranslational processing processes. By complementation of the lep(ts) E. coli mutant strain IT41 it was demonstrated that sipF indeed encodes a functional signal peptidase, and genetic complementation of B. japonicum mutant 184 by a 2.8-kb SalI fragment indicated that sipF is expressed from a promoter located directly upstream of sipF. Using a non-polar kanamycin resistance cassette, a specific sipF mutant was constructed which exhibited defects in symbiosis similar to those of the original mutant 184.

  1. Bridged HPSi and Linear HSiP as Probes of the SiP Radical in Astrophysical/Interstellar Media

    NASA Astrophysics Data System (ADS)

    Fortenberry, Ryan C.; Francisco, Joseph S.

    2017-07-01

    The SiP radical has a \\tilde{X}{}2{{\\Pi }} ground state and a low-lying A{}2{{{Σ }}}+ state with a transition wavelength of greater than 20 μm. However, this transition has a near-zero oscillator strength making it all but unobservable. Addition of a hydrogen atom to the system creates the strangely bent HPSi molecule and also the linear HSiP isomer, lying 0.50 eV above the bent. The electron-deficient P-Si π cloud in \\tilde{X}{}2{{\\Pi }} SiP is stabilized by the addition of the hydrogen atom, making this isomer the preferred form of HPSi. The HSiP linear isomer can be formed from A{}2{{{Σ }}}+ SiP. As a result, the [HPSi]/[HSiP] ratio could serve as tracer of the otherwise unobservable but low-lying A{}2{{{Σ }}}+≤ftarrow \\tilde{X}{}2{{\\Pi }} electronic transition of SiP. The high-level quantum chemical computations employed here imply that the rotational lines of HPSi and HSiP will overlap extensively, but the vibrational frequencies, especially the hydride stretch, are significantly separated. The hydride stretches are in the 5 μm range, making them excellent candidates for mid-IR observations with the Stratsopheric Observatory for Infrared Astronomy or with the James Webb Space Telescope. Furthermore, the rotational constants and vibrational frequencies of \\tilde{X}{}2{{\\Pi }} SiP, A{}2{{{Σ }}}+ SiP, and \\tilde{X}{}1{{{Σ }}}+ SiP- are also provided in addition to the relative energies of all five species.

  2. Safety and immunogenicity of an oral DNA vaccine encoding Sip of Streptococcus agalactiae from Nile tilapia Oreochromis niloticus delivered by live attenuated Salmonella typhimurium.

    PubMed

    Huang, L Y; Wang, K Y; Xiao, D; Chen, D F; Geng, Y; Wang, J; He, Y; Wang, E L; Huang, J L; Xiao, G Y

    2014-05-01

    Attenuated Salmonella typhimurium SL7207 was used as a carrier for a reconstructed DNA vaccine against Streptococcus agalactiae. A 1.02 kb DNA fragment, encoding for a portion of the surface immunogenic protein (Sip) of S. agalactiae was inserted into pVAX1. The recombinant plasmid pVAX1-sip was transfected in EPC cells to detect the transient expression by an indirect immunofluorescence assay, together with Western blot analysis. The pVAX1-sip was transformed by electroporation into SL7207. The stability of pVAX1-sip into Salmonella was over 90% after 50 generations with antibiotic selection in vitro while remained stable over 80% during 35 generations under antibiotic-free conditions. The LD50 of SL/pVAX1-sip was 1.7 × 10(11) CFU/fish by intragastric administration which indicated a quite low virulence. Tilapias were inoculated orally at 10(8) CFU/fish, the recombinant bacteria were found present in intestinal tract, spleens and livers and eventually eliminated from the tissues 4 weeks after immunization. Fish immunized at 10(7), 10(8) and 10(9) CFU/fish with different immunization times caused various levels of serum antibody and an effective protection against lethal challenge with the wild-type strain S. agalactiae. Integration studies showed that the pVAX1-sip did not integrate with tilapia chromosomes. The DNA vaccine SL/pVAX1-sip was proved to be safe and effective in protecting tilapias against S. agalactiae infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. 76 FR 27649 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... Disadvantaged Communities, SIP11-041, Feasibility Study to Link Data from the National Breast and Cervical..., Management Analysis and Services Office, CDC, pursuant to Public Law 92-463. Matters To Be Discussed: The... Promote Colorectal Cancer Screening in Disadvantaged Communities, SIP11-041, Feasibility Study to Link...

  4. 78 FR 4804 - Revision to the Washington State Implementation Plan; Tacoma-Pierce County Nonattainment Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... Plan (SIP) revision submitted by the Washington Department of Ecology (Ecology) dated November 28, 2012... Air Quality Standard (NAAQS). Second, EPA is proposing to approve updated rules submitted by Ecology... emissions. II. Summary of SIP Revision Ecology's November 28, 2012 SIP revision contains two elements for...

  5. Social Information Processing as a Mediator between Cognitive Schemas and Aggressive Behavior in Adolescents

    ERIC Educational Resources Information Center

    Calvete, Esther; Orue, Izaskun

    2012-01-01

    This longitudinal investigation assessed whether cognitive schemas of justification of violence, mistrust, and narcissism predicted social information processing (SIP), and SIP in turn predicted aggressive behavior in adolescents. A total of 650 adolescents completed measures of cognitive schemas at Time 1, SIP in ambiguous social scenarios at…

  6. 77 FR 24843 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Removal of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... requirements for large stationary internal combustion engines under the NO X SIP Call. Transco Station 175 has...), large stationary internal combustion engines, and large cement kilns. The NO X SIP Call was challenged... internal combustion engines and large cement kilns. EPA approved Virginia's Phase I NO X SIP Call...

  7. 77 FR 60053 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... Deterioration and Nonattainment New Source Review; Fine Particulate Matter (PM2.5) AGENCY: Environmental... preconstruction permitting requirements for fine particulate matter (PM 2.5 ) into the Delaware SIP. In addition... fine particulate matter (PM 2.5 ) into the Delaware SIP. In addition, EPA proposed approval of SIP...

  8. 40 CFR 52.2306 - Particulate Matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Particulate Matter (PM10) Group II SIP commitments. 52.2306 Section 52.2306 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate Matter (PM10) Group II SIP commitments. On July 18, 1988, the Governor of Texas submitted a...

  9. 40 CFR 52.2306 - Particulate Matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Particulate Matter (PM10) Group II SIP commitments. 52.2306 Section 52.2306 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate Matter (PM10) Group II SIP commitments. On July 18, 1988, the Governor of Texas submitted a...

  10. 40 CFR 52.1637 - Particulate Matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Particulate Matter (PM10) Group II SIP commitments. 52.1637 Section 52.1637 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate Matter (PM10) Group II SIP commitments. (a) On August 19, 1988, the Governor of New Mexico...

  11. 40 CFR 52.1637 - Particulate Matter (PM10) Group II SIP commitments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Particulate Matter (PM10) Group II SIP commitments. 52.1637 Section 52.1637 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate Matter (PM10) Group II SIP commitments. (a) On August 19, 1988, the Governor of New Mexico...

  12. 77 FR 45949 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Preconstruction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ... (SIP) submitted by the Maryland Department of the Environment (MDE). These revisions pertain to... are listed in the www.regulations.gov Web site. Although listed in the electronic docket, some... submitted by MDE, as described below. II. Summary of SIP Revision A. SIP Revision 07-13 On October 24, 2007...

  13. 76 FR 69895 - Approval and Promulgation of Implementation Plans; California; 2008 San Joaquin Valley PM2.5

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... Control District and the California Air Resources Board. Finally, it is disapproving the SIP's contingency... that SIP revision on July 29, 2011. EPA also proposed to disapprove the contingency measures provisions... also today disapproving the SIP's contingency measure provisions because they do not provide sufficient...

  14. 78 FR 77628 - Approval and Promulgation of Air Quality Implementation Plans; New Hampshire; Manchester and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Hampshire Department of Environmental Services (NH DES) submitted a SIP revision to EPA that contained... 8-hour CO standard. On August 1, 2012, the NH DES submitted a limited maintenance plan SIP revision... DES's SIP revision uses EPA's limited maintenance plan approach, as detailed in the EPA guidance...

  15. An Item Response Theory (IRT) analysis of the Short Inventory of Problems-Alcohol and Drugs (SIP-AD) among non-treatment seeking men-who-have-sex-with-men: evidence for a shortened 10-item SIP-AD.

    PubMed

    Hagman, Brett T; Kuerbis, Alexis N; Morgenstern, Jon; Bux, Donald A; Parsons, Jeffrey T; Heidinger, Bram E

    2009-11-01

    The Short Inventory of Problems-Alcohol and Drugs (SIP-AD) is a 15-item measure that assesses concurrently negative consequences associated with alcohol and illicit drug use. Current psychometric evaluation has been limited to classical test theory (CTT) statistics, and it has not been validated among non-treatment seeking men-who-have-sex-with-men (MSM). Methods from Item Response Theory (IRT) can improve upon CTT by providing an in-depth analysis of how each item performs across the underlying latent trait that it is purported to measure. The present study examined the psychometric properties of the SIP-AD using methods from both IRT and CTT among a non-treatment seeking MSM sample (N=469). Participants were recruited from the New York City area and were asked to participate in a series of studies examining club drug use. Results indicated that five items on the SIP-AD demonstrated poor item misfit or significant differential item functioning (DIF) across race/ethnicity and HIV status. These five items were dropped and two-parameter IRT analyses were conducted on the remaining 10 items, which indicated a restricted range of item location parameters (-.15 to -.99) plotted at the lower end of the latent negative consequences severity continuum, and reasonably high discrimination parameters (1.30 to 2.22). Additional CTT statistics were compared between the original 15-item SIP-AD and the refined 10-item SIP-AD and suggest that the differences were negligible with the refined 10-item SIP-AD indicating a high degree of reliability and validity. Findings suggest the SIP-AD can be shortened to 10 items and appears to be a non-biased reliable and valid measure among non-treatment seeking MSM.

  16. Executive function is necessary for the regulation of the stepping activity when stepping in place in older adults.

    PubMed

    Dalton, Christopher; Sciadas, Ria; Nantel, Julie

    2016-10-01

    To determine the effect of age on stepping performance and to compare the cognitive demand required to regulate repetitive stepping between older and younger adults while performing a stepping in place task (SIP). Fourteen younger (25.4 ± 6.5) and 15 older adults (71.0 ± 9.0) participated in this study. They performed a seated category fluency task and Stroop test, followed by a 60 s SIP task. Following this, both the cognitive and motor tasks were performed simultaneously. We assessed cognitive performance, SIP cycle duration, asymmetry, and arrhythmicity. Compared to younger adults, older adults had larger SIP arrhythmicity both as a single task and when combined with the Category (p < 0.001) and Stroop (p < 0.01) tasks. Older adults also had larger arrhythmicity when dual tasking compared to SIP alone (p < 0.001). Older adults showed greater SIP asymmetry when combined with Category (p = 0.006) and Stroop (p = 0.06) tasks. Finally, they had lower cognitive performance than younger adults in both single and dual tasks (p < 0.01). Age and type of cognitive task performed with the motor task affected different components of stepping. While SIP arrhythmicity was larger for all conditions in older compared to younger adults, cycle duration was not different, and asymmetry tended to be larger during SIP when paired with a verbal fluency task. SIP does not require a high level of control for dynamic stability, therefore demonstrating that higher-level executive function is necessary for the regulation of stepping activity independently of the regulation of postural balance. Furthermore, older adults may lack the cognitive resources needed to adequately regulate stepping activity while performing a cognitive task relying on the executive function.

  17. High resolution, low cost solar cell contact development. Quarterly technical progress and schedule report, September 28, 1980

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mardesich, N.

    The scope of the contract covers the development and evaluation of forming solar cell collector grid contacts by the MIDFILM process. This is a proprietary process developed by the Ferro Corporation which is a subcontractor for the program. The MIDFILM process attains line resolution characteristics of photoresist methods with processing related to screen printing. The surface to be processed is first coated with a thin layer of photoresist material. Upon exposure to ultraviolet light through a suitable mask, the resist in the non-pattern area cross-links and becomes hard. The unexposed pattern areas remain tacky. The conductor material is applied inmore » the form of a dry mixture of metal and frit particles which adhere to the tacky pattern area. The assemblage is then fired to ash the photopolymer and sinter the fritted conductor powder. Effort was concentrated during this period on the establishment, optimization and identification of problem areas of the MIDFILM process. Progress is reported. (WHK)« less

  18. 76 FR 4948 - Program for Allocation of Regulatory Responsibilities Pursuant to Rule 17d-2; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Control. In the event of a change of control of a Listing Market, the Listing Market will have the... Agreement from (a) the Consolidated Tape Association (``CTA'') as the exclusive securities information... Unlisted Trading Privileges Plan as the exclusive SIP for all NASDAQ[-listed securities] Listed Stocks. b...

  19. 77 FR 34897 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Permit to Construct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...-0394, Ms. Kathleen Cox, Associate Director, Office of Permits and Air Toxics, Mailcode 3AP10, U.S... preconstruction permitting requirements under Maryland's New Source Review (NSR) program. In the Final Rules section of this Federal Register, EPA is approving the State's SIP submittal as a direct final rule...

  20. 77 FR 28543 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Permit To Construct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ...-0292, Ms. Kathleen Cox, Associate Director, Office of Permits and Air Toxics, Mailcode 3AP10, U.S... preconstruction permitting requirements under Maryland's New Source Review (NSR) program. In the Final Rules section of this Federal Register, EPA is approving the State's SIP submittal as a direct final rule...

  1. 78 FR 19602 - Approval and Promulgation of Implementation Plans and Operating Permits Program; State of Missouri

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... of VOC. The SIP revision also corrects two asbestos method subpart references. This revision also...-6.020(c) for Category I nonfriable asbestos containing material (ACM), and Category II nonfriable... Reference Tables (2)(C)3 and (2)(C)4 dated November 30, 2010. Although asbestos is not regulated under the...

  2. 78 FR 30209 - Approval and Promulgation of Implementation Plans; Arizona; Motor Vehicle Inspection and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... 2280 amends the Arizona Revised Statutes (ARS) section 49-542 (``Emissions inspection program; powers... motorcycles from the VEI emissions testing requirement. \\2\\ The changes to ARS Section 49-542 are self... appendix A of the 2009 VEI SIP Revision with a certified copy of the codified version of ARS section 49-542...

  3. 76 FR 2581 - Action To Ensure Authority To Issue Permits Under the Prevention of Significant Deterioration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... or Act) Prevention of Significant Deterioration (PSD) program to sources of greenhouse gases (GHGs... issue preconstruction PSD permits to GHG- emitting sources. This action is related to EPA's recent final rule, the GHG PSD SIP Call, published on December 13, 2010, in which EPA made a finding of substantial...

  4. Regional softwood sawmill processing variables as influenced by productive capacity

    Treesearch

    P. H. Steele; F. G. Wagner; K. E. Skog

    The relationship between annual softwood sawmill production and lumber processing variables was examined using data from Sawmill Improvement Program (SIP) studies of 650 softwood mills. The variables were lumber recovery factor (LRF); headrig and resaw kerf width; total sawing variation, rough green size, and oversizing-undersizing for 4/4 and 8/4 lumber; planer...

  5. 78 FR 11805 - Approval and Promulgation of Implementation Plans; Region 4 States; 110(a)(2)(D)(i)(II...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... retrofit technology (BART) and reasonable progress requirements for other sources or pollutants, are..., South Carolina and Tennessee regional haze SIPs, indicating that except for its reliance on CAIR, the... Tennessee, which merely substituted reliance on EPA's more recent CSAPR's NO X and SO 2 trading programs for...

  6. Effortful Control, Social Information Processing, and the Prevention of Aggression in Elementary Schools

    ERIC Educational Resources Information Center

    Ellis, Alan Reid

    2012-01-01

    Early aggression is a problem in its own right and a risk factor for further developmental problems. Although both effortful control and social information processing (SIP) skills are negatively associated with aggression and are targeted by aggression prevention programs, little is known about the relation between them or about their joint…

  7. Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS

    PubMed Central

    Fusar-Poli, P.; Cappucciati, M.; Rutigliano, G.; Lee, T. Y.; Beverly, Q.; Bonoldi, I.; Lelli, J.; Kaar, S. J.; Gago, E.; Rocchetti, M.; Patel, R.; Bhavsar, V.; Tognin, S.; Badger, S.; Calem, M.; Lim, K.; Kwon, J. S.; Perez, J.; McGuire, P.

    2016-01-01

    Background. Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR) of psychosis. Their diagnostic comparability is unknown. Methods. All referrals to the OASIS (London) or CAMEO (Cambridgeshire) UHR services from May 13 to Dec 14 were interviewed for a UHR state using both the CAARMS 12/2006 and the SIPS 5.0. Percent overall agreement, kappa, the McNemar-Bowker χ 2 test, equipercentile methods, and residual analyses were used to investigate diagnostic outcomes and symptoms severity or frequency. A conversion algorithm (CONVERT) was validated in an independent UHR sample from the Seoul Youth Clinic (Seoul). Results. There was overall substantial CAARMS-versus-SIPS agreement in the identification of UHR subjects (n = 212, percent overall agreement = 86%; kappa = 0.781, 95% CI from 0.684 to 0.878; McNemar-Bowker test = 0.069), with the exception of the brief limited intermittent psychotic symptoms (BLIPS) subgroup. Equipercentile-linking table linked symptoms severity and frequency across the CAARMS and SIPS. The conversion algorithm was validated in 93 UHR subjects, showing excellent diagnostic accuracy (CAARMS to SIPS: ROC area 0.929; SIPS to CAARMS: ROC area 0.903). Conclusions. This study provides initial comparability data between CAARMS and SIPS and will inform ongoing multicentre studies and clinical guidelines for the UHR psychometric diagnostic interview. PMID:27314005

  8. 77 FR 58032 - Approval and Promulgation of Implementation Plans; New Mexico; Albuquerque/Bernalillo County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... prevention of significant deterioration (PSD) measures required in the SIP of any other state, with regard to... modify the PSD SIP to include nitrogen oxides (NO X ) as an ozone precursor. EPA is approving revisions to the Albuquerque/Bernalillo County PSD SIP that identify the PM 2.5 precursors and establish...

  9. 77 FR 31358 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... announced below concerns Research to Enhance Community- Based Fall Prevention among Older Adults, SIP12-058, and Developing a Compendium of Measures and Questions to Assess Mobility: A Focus on Older Adult... Older Adults, SIP12-058, and Developing a Compendium of Measures and Questions to Assess Mobility: A...

  10. 40 CFR 52.1489 - Particulate matter (PM-10) Group II SIP commitments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Particulate matter (PM-10) Group II SIP commitments. 52.1489 Section 52.1489 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate matter (PM-10) Group II SIP commitments. (a) On March 29, 1989, the Air Quality Officer for the...

  11. 40 CFR 52.1489 - Particulate matter (PM-10) Group II SIP commitments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Particulate matter (PM-10) Group II SIP commitments. 52.1489 Section 52.1489 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Particulate matter (PM-10) Group II SIP commitments. (a) On March 29, 1989, the Air Quality Officer for the...

  12. 75 FR 6813 - Approval of Air Quality Implementation Plans; New Mexico; Albuquerque/Bernalillo County

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-11

    ...). ACTION: Direct final rule. SUMMARY: The EPA is approving revisions to the State Implementation Plan (SIP.... Background III. Summary of Changes to the New Mexico SIP IV. Final Action V. Statutory and Executive Order Reviews I. What Action Is EPA Taking? Today we are approving revisions to the New Mexico SIP, submitted by...

  13. 77 FR 62449 - Approval and Promulgation of Implementation Plans; Alabama; Disapproval of 110(a)(2)(E)(ii...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... in their comment that EPA approve a conflict of interest protocol submitted for inclusion in the SIP... that with the inclusion of this protocol in the SIP, EPA would be able to approve Alabama's 1997 annual... the State Implementation Plan (SIP) submissions, submitted by the State of Alabama, through the...

  14. 76 FR 41424 - Finding of Substantial Inadequacy of Implementation Plan; Call for Iowa State Implementation Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... modeling requirement for this SIP call should allow for the use of the modeling protocol developed by Iowa... is making a finding that the Iowa State Implementation Plan (SIP) is substantially inadequate to... ) in Muscatine County, Iowa. The specific SIP deficiencies needing revision are described below. EPA is...

  15. 75 FR 6336 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Removal of NOX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Promulgation of Air Quality Implementation Plans; West Virginia; Removal of NOX SIP Call Rules AGENCY... Implementation Plan (SIP) revision submitted by the State of West Virginia that removes West Virginia's nitrogen oxides (NOx) SIP Call rules. In the Final Rules section of this Federal Register, EPA is approving the...

  16. Do Social Information-Processing Models Explain Aggressive Behaviour by Children with Mild Intellectual Disabilities in Residential Care?

    ERIC Educational Resources Information Center

    van Nieuwenhuijzen, M.; de Castro, B. O.; van der Valk, I.; Wijnroks, L.; Vermeer, A.; Matthys, W.

    2006-01-01

    Background: This study aimed to examine whether the social information-processing model (SIP model) applies to aggressive behaviour by children with mild intellectual disabilities (MID). The response-decision element of SIP was expected to be unnecessary to explain aggressive behaviour in these children, and SIP was expected to mediate the…

  17. 75 FR 16706 - Approval and Promulgation of Implementation Plans; Texas; Revisions to Voiding of Permits and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Promulgation of Implementation Plans; Texas; Revisions to Voiding of Permits and Extension of Permits AGENCY... Implementation Plan (SIP). Within this SIP submittal, the State repealed a paragraph of the SIP rule pertaining... met, including a health effects review. EPA is proposing to approve the new replacement rule for this...

  18. Relationship between pore geometric characteristics and SIP/NMR parameters observed for mudstones

    NASA Astrophysics Data System (ADS)

    Robinson, J.; Slater, L. D.; Keating, K.; Parker, B. L.; Robinson, T.

    2017-12-01

    The reliable estimation of permeability remains one of the most challenging problems in hydrogeological characterization. Cost effective, non-invasive geophysical methods such as spectral induced polarization (SIP) and nuclear magnetic resonance (NMR) offer an alternative to traditional sampling methods as they are sensitive to the mineral surfaces and pore spaces that control permeability. We performed extensive physical characterization, SIP and NMR geophysical measurements on fractured rock cores extracted from a mudstone site in an effort to compare 1) the pore size characterization determined from traditional and geophysical methods and 2) the performance of permeability models based on these methods. We focus on two physical characterizations that are well-correlated with hydraulic properties: the pore volume normalized surface area (Spor) and an interconnected pore diameter (Λ). We find the SIP polarization magnitude and relaxation time are better correlated with Spor than Λ, the best correlation of these SIP measures for our sample dataset was found with Spor divided by the electrical formation factor (F). NMR parameters are, similarly, better correlated with Spor than Λ. We implement previously proposed mechanistic and empirical permeability models using SIP and NMR parameters. A sandstone-calibrated SIP model using a polarization magnitude does not perform well while a SIP model using a mean relaxation time performs better in part by more sufficiently accounting for the effects of fluid chemistry. A sandstone-calibrated NMR permeability model using an average measure of the relaxation time does not perform well, presumably due to small pore sizes which are either not connected or contain water of limited mobility. An NMR model based on the laboratory determined portions of the bound versus mobile portions of the relaxation distribution performed reasonably well. While limitations exist, there are many opportunities to use geophysical data to predict permeability in mudstone formations.

  19. 78 FR 58460 - Revision of Air Quality Implementation Plan; California; Placer County Air Pollution Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ...EPA is finalizing a limited approval and limited disapproval of two permitting rules submitted by California as a revision to the Placer County Air Pollution Control District (PCAPCD) and Feather River Air Quality Management District (FRAQMD) portion of the California State Implementation Plan (SIP). These revisions were proposed in the Federal Register on February 22, 2013 and concern construction and modification of stationary sources of air pollution within each District. We are approving local rules that regulate these emission sources under the Clean Air Act as amended in 1990 (CAA). Final approval of these rules makes the rules federally enforceable and corrects program deficiencies identified in a previous EPA rulemaking (76 FR 44809, July 27, 2011). EPA is also making a technical amendment to the Code of Federal Regulations (CFR) to reflect this previous rulemaking, which removed an obsolete provision from the California SIP.

  20. "How Would You Feel? What Would You Do?" Development and Underpinnings of Preschoolers' Social Information Processing

    ERIC Educational Resources Information Center

    Denham, Susanne A.; Bassett, Hideko Hamada; Way, Erin; Kalb, Sara; Warren-Khot, Heather; Zinsser, Katherine

    2014-01-01

    Young children's social information processing (SIP) encompasses a series of steps by which they make sense of encounters with other persons; cognitive and emotional aspects of SIP often predict adjustment in school settings. More attention is needed, however, to the development of preschoolers' SIP and its potential foundations. To this end, a…

  1. 40 CFR 57.205 - Submission of supplementary information upon relaxation of an SO2 SIP emission limitation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Submission of supplementary information upon relaxation of an SO2 SIP emission limitation. 57.205 Section 57.205 Protection of Environment... Application and the NSO Process § 57.205 Submission of supplementary information upon relaxation of an SO2 SIP...

  2. Examining Factors Associated with (In)Stability in Social Information Processing among Urban School Children: A Latent Transition Analytic Approach

    ERIC Educational Resources Information Center

    Goldweber, Asha; Bradshaw, Catherine P.; Goodman, Kimberly; Monahan, Kathryn; Cooley-Strickland, Michele

    2011-01-01

    There is compelling evidence for the role of social information processing (SIP) in aggressive behavior. However, less is known about factors that influence stability versus instability in patterns of SIP over time. Latent transition analysis was used to identify SIP patterns over one year and examine how community violence exposure, aggressive…

  3. Fact Sheet on Revisions to the Clean Air Act Section 110 Submission Requirements for State Implementation Plans and Notice of Availability of an Option for Electronic Reporting

    EPA Pesticide Factsheets

    On February 3, 2015, the U.S. Environmental Protection Agency notified state, local and tribal air agencies that they have the option to submit state implementation plans (SIPs) using the EPA’s new electronic web-based SIP (eSIP) submission system.

  4. SIP Shear Walls: Cyclic Performance of High-Aspect-Ratio Segments and Perforated Walls

    Treesearch

    Vladimir Kochkin; Douglas R. Rammer; Kevin Kauffman; Thomas Wiliamson; Robert J. Ross

    2015-01-01

    Increasing stringency of energy codes and the growing market demand for more energy efficient buildings gives structural insulated panel (SIP) construction an opportunity to increase its use in commercial and residential buildings. However, shear wall aspect ratio limitations and lack of knowledge on how to design SIPs with window and door openings are barriers to the...

  5. microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells.

    PubMed

    Sathyanarayanan, Anusha; Chandrasekaran, Karthik Subramanian; Karunagaran, Devarajan

    2017-04-01

    Previously, it has been reported that microRNA-145 (miR-145) is lowly expressed in human cervical cancers and that its putative tumour suppressive role may be attributed to epithelial-mesenchymal transition (EMT) regulation. Here, we aimed to assess whether miR-145 may affect EMT-associated markers/genes and suppress cervical cancer growth and motility, and to provide a mechanistic basis for these phenomena. The identification of the SMAD-interacting protein 1 (SIP1) mRNA as putative miR-145 target was investigated using a 3' untranslated region (3'UTR) luciferase assay and Western blotting, respectively. The functional effects of exogenous miR-145 expression, miR-145 suppression or siRNA-mediated SIP1 expression down-regulation in cervical cancer-derived C33A and SiHa cells were analysed using Western blotting, BrdU incorporation (proliferation), transwell migration and invasion assays. In addition, the expression levels of miR-145 and SIP1 were determined in primary human cervical cancer and non-cancer tissue samples using qRT-PCR. We found that miR-145 binds to the wild-type 3'UTR of SIP1, but not to its mutant counterpart, and that, through this binding, miR-145 can effectively down-regulate SIP1 expression. In addition, we found that exogenous miR-145 expression or siRNA-mediated down-regulation of SIP1 expression attenuates the proliferation, migration and invasion of C33A and SiHa cells and alters the expression of the EMT-associated markers CDH1, VIM and SNAI1, whereas inhibition of endogenous miR-145 expression elicited the opposite effects. The expression of miR-145 in cervical cancer tissue samples was found to be low, while that of SIP1 was found to be high compared to non-cancerous cervical tissues. An inverse expression correlation between the two was substantiated through the anlaysis of data deposited in the TCGA database. Our data indicate that low miR-145 expression levels in conjunction with elevated SIP1 expression levels may contribute to cervical cancer development. MiR-145-mediated regulation of SIP1 provides a novel mechanistic basis for its tumour suppressive mode of action in human cervical cancer cells.

  6. The Water SWITCH-ON Spatial Information Platform (SIP)

    NASA Astrophysics Data System (ADS)

    Sala Calero, J., Sr.; Boot, G., Sr.; Dihé, P., Sr.; Arheimer, B.

    2017-12-01

    The amount of hydrological open data is continually growing and providing opportunities to the scientific community. Although the existing data portals (GEOSS Portal, INSPIRE community geoportal and others) enable access to open data, many users still find browsing through them difficult. Moreover, the time spent on gathering and preparing data usually is more significant than the time spent on the experiment itself. Thus, any improvement on searching, understanding, accessing or using open data is greatly beneficial. The Spatial Information Platform (SIP) has been developed to tackle these issues within the SWITCH-ON European Commission funded FP7 project. The SIP has been designed as a set of tools based on open standards that provide to the user all the necessary functionalities as described in the Publish-Find-Bind (PFB) pattern. In other words, this means that the SIP helps users to locate relevant and suitable data for their experiments analysis, to access and transform it (filtering, extraction, selection, conversion, aggregation). Moreover, the SIP can be used to provide descriptive information about the data and to publish it so others can find and use it. The SIP is based on existing open data protocols such as the OGC/CSW, OGC/WMS, OpenDAP and open-source components like PostgreSQL/PostGIS, GeoServer and pyCSW. The SIP is divided in three main user interfaces: the BYOD (Browse your open dataset) web interface, the Expert GUI tool and the Upload Data and Metadata web interface. The BYOD HTML5 client is the main entry point for users that want to browse through open data in the SIP. The BYOD has a map interface based on Leaflet JavaScript libraries so that the users can search more efficiently. The web-based Open Data Registration Tool is a user-friendly upload and metadata description interface (geographical extent, license, DOI generation). The Expert GUI is a desktop application that provides full metadata editing capabilities for the metadata moderators of the project. In conclusion, the Spatial Information Platform (SIP) provides to its community a set of tools for better understanding and ease of use of hydrological open-data. Moreover, the SIP has been based on well-known OGC standards that will allow the connection and data harvesting from popular open data portals such as the GEOSS system of systems.

  7. Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice.

    PubMed

    Le, X Y; Luo, P; Gu, Y P; Tao, Y X; Liu, H Z

    2015-01-01

    Cyclophosphamide (CP) is a commonly used antitumour and immunosuppressive drug, but it is inevitable that the chemotherapeutic agent may cause long-term or permanent reproductive damage on young male patients through inducing oxidative stress in the testes. Squid ink polysaccharides (SIP), a newly found marine glycosaminoglycon have been proved to have antioxidant capabilities and chemotherapy-protective activities on model animals in our recent investigations. This study was conducted to assess whether or not SIP could protect male mice against gonadotoxicity during CP exposure. Sexually mature male Kunming mice were allocated to one of four groups. CP was abdominally administered at dose of 15 mg/kg body weight to two groups of mice for ten weeks, once a week, one group of mice received SIP at dose of 80 mg/kg body weight by gavage for ten weeks, once a day. The other two groups comprised a vehicle treated group and an SIP treated group. Toxicity of CP and protective activity of SIP on the testes were assessed by: sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sex hormone content, and histopathological features. Data showed CP-induced, serious negative changes on murine sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sexual hormone contents, and histopathological features which were all significantly impaired by SIP. This study found that SIP were demonstrated to offer protective effects against CP-induced toxicity on testes in mice (Tab. 2, Fig. 3, Ref. 29).

  8. Effectiveness of urban shelter-in-place—II: Residential districts

    NASA Astrophysics Data System (ADS)

    Chan, Wanyu R.; Nazaroff, William W.; Price, Phillip N.; Gadgil, Ashok J.

    In the event of a short-term, large-scale toxic chemical release to the atmosphere, shelter-in-place (SIP) may be used as an emergency response to protect public health. We modeled hypothetical releases using realistic, empirical parameters to explore how key factors influence SIP effectiveness for single-family dwellings in a residential district. Four classes of factors were evaluated in this case study: (a) time scales associated with release duration, SIP implementation delay, and SIP termination; (b) building air-exchange rates, including air infiltration and ventilation; (c) the degree of sorption of toxic chemicals to indoor surfaces; and (d) the shape of the dose-response relationship for acute adverse health effects. Houses with lower air leakage are more effective shelters, and thus variability in the air leakage of dwellings is associated with varying degrees of SIP protection in a community. Sorption on indoor surfaces improves SIP effectiveness by lowering the peak indoor concentrations and reducing the amount of contamination in the indoor air. Nonlinear dose-response relationships imply substantial reduction in adverse health effects from lowering the peak exposure concentration. However, if the scenario is unfavorable for indefinite sheltering (e.g. sheltering in leaky houses for protection against a nonsorbing chemical with a linear dose-response), the community must implement SIP without delay and exit from shelter when it first becomes safe to do so. Otherwise, the community can be subjected to even greater risk than if they did not take shelter indoors.

  9. Psychometric properties of a Spanish-language version of the Short Inventory of Problems

    PubMed Central

    Kiluk, Brian D.; Dreifuss, Jessica A.; Weiss, Roger D.; Horigian, Viviana E.; Carroll, Kathleen M.

    2013-01-01

    Hispanic Americans are substantially under-represented in clinical and research samples for substance use treatment, with language cited as one of the major barriers to their participation, indicating a need for more validated assessments in Spanish. This study evaluated the psychometric properties of a Spanish version of the Short Inventory of Problems (SIP), used in a multisite, randomized trial conducted for Spanish-speaking substance users. The sample included 405 Spanish-speaking treatment seekers, mostly male (88%) and legally mandated to treatment (71%). The Spanish version of the revised SIP (SIP-RS), as well as other commonly-used assessment measures translated into Spanish, were administered at baseline and at the end of treatment. Internal consistency was excellent (α = .96), and construct validity was supported through correlations with composite scores from the Addiction Severity Index (ASI) (e.g., r = .57, p<.01 for ASI drug composite), and through differential SIP-RS scores according to diagnostic criteria. The SIP-RS also demonstrated an association with substance use and treatment retention, with higher baseline scores associated with significantly less abstinence during treatment (β = −.22, p<.01) and fewer days retained in treatment (β = −.14, p<.05). However, the latter association was moderated by participants’ legal status. Nevertheless, this Spanish-translated version of the SIP (SIP-RS) appears to be a reliable and valid assessment of adverse consequences associated with alcohol and drug use, with psychometric properties comparable to the English version. PMID:23772760

  10. 77 FR 59100 - Approval and Promulgation of Implementation Plans; Alabama: General and Transportation Conformity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... PM 10 surrogate program; and (5) require states to account for gases that condense to form particles (condensables) in PM 2.5 and PM 10 emission limits in PSD NNSR permits. Additionally, the NSR PM 2.5 Rule... PSD portion of the State's May 2, 2011, SIP revision. 1. PM 10 Surrogate and Grandfathering Policy In...

  11. 76 FR 30600 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Revisions to Clean Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... business hours at the Air Protection Division, U.S. Environmental Protection Agency, Region III, 1650 Arch...) with a State plan based on the CAIR model rule that would allow subject sources, non-EGUs from its... program, definitions associated with the State's decision to bring its non-EGUs from its NO X SIP Call...

  12. 77 FR 50602 - Approval and Promulgation of Air Quality Implementation Plans; New Hampshire; Regional Haze

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... placed on the Internet and will be publicly available only in hard copy form. Publicly available docket...), New Hampshire has committed to submit to EPA a progress report, in the form of a SIP revision, every... Trading Program limits ozone season NO X emissions on all fossil-fuel fired EGUs greater than 15 MW...

  13. 77 FR 33380 - Approval and Promulgation of Implementation Plans; South Carolina; 110(a)(1) and (2)(E) and (G...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... infrastructure elements for the 1997 and 2006 PM 2.5 NAAQS, however the subject of this notice is limited to... had submitted or failed to submit a complete SIP that provided the basic program elements of section.... The requirements that are the subject of the infrastructure rulemaking process are listed below \\1...

  14. 77 FR 33372 - Approval and Promulgation of Implementation Plans; South Carolina; 110(a)(1) and (2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... analysis of how South Carolina addressed the elements of sections 110(a)(1) and (2) ``Infrastructure... failed to submit a complete SIP that provided the basic program elements of section 110(a)(2) necessary... elements identified in section 110(a)(2) are not governed by the three year submission deadline of section...

  15. 77 FR 21453 - Approval and Promulgation of Air Quality Implementation Plans; Colorado; Revisions to New Source...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ...EPA is approving those revisions adopted by the State of Colorado on April 16, 2004 to Regulation No. 3 (Stationary Source Permitting and Air Pollutant Emission Notice Requirements) that incorporate EPA's December 31, 2002 NSR Reforms. Colorado submitted the request for approval of these rule revisions into the State Implementation Plan (SIP) on July 11, 2005 and supplemented its request on October 25, 2005. EPA is approving only the portions of Colorado's revisions to Regulation Number 3 that relate to the prevention of significant deterioration (PSD) and non-attainment new source review (NSR) construction permit programs of the State of Colorado. Other revisions, renumberings, additions, or deletions to Regulation No. 3 made by Colorado as part of the April 16, 2004 final rulemaking are being acted on by EPA in a separate final action related to Colorado's Interstate Transport SIP (see proposed action at 76 FR 21835, April 19, 2011). Colorado has a federally approved NSR program for new and modified sources impacting attainment and non-attainment areas in the State. This action is being taken under section 110 of the Clean Air Act (CAA).

  16. New developments in developmental research on social information processing and antisocial behavior.

    PubMed

    Fontaine, Reid Griffith

    2010-07-01

    The Special Section on developmental research on social information processing (SIP) and antisocial behavior is here introduced. Following a brief history of SIP theory, comments on several themes-measurement and assessment, attributional and interpretational style, response evaluation and decision, and the relation between emotion and SIP-that tie together four new empirical investigations are provided. Notable contributions of these studies are highlighted.

  17. Spacecraft dielectric material properties and spacecraft charging

    NASA Technical Reports Server (NTRS)

    Frederickson, A. R.; Wall, J. A.; Cotts, D. B.; Bouquet, F. L.

    1986-01-01

    The physics of spacecraft charging is reviewed, and criteria for selecting and testing semiinsulating polymers (SIPs) to avoid charging are discussed and illustrated. Chapters are devoted to the required properties of dielectric materials, the charging process, discharge-pulse phenomena, design for minimum pulse size, design to prevent pulses, conduction in polymers, evaluation of SIPs that might prevent spacecraft charging, and the general response of dielectrics to space radiation. SIPs characterized include polyimides, fluorocarbons, thermoplastic polyesters, poly(alkanes), vinyl polymers and acrylates, polymers containing phthalocyanine, polyacene quinones, coordination polymers containing metal ions, conjugated-backbone polymers, and 'metallic' conducting polymers. Tables summarizing the results of SIP radiation tests (such as those performed for the NASA Galileo Project) are included.

  18. Student Intern Ben Freed Competes as Finalist in Intel STS Competition, Three Other Interns Named Semifinalists | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Werner H. Kirstin (WHK) student intern Ben Freed was one of 40 finalists to compete in the Intel Science Talent Search (STS) in Washington, DC, in March. “It was seven intense days of interacting with amazing judges and incredibly smart and interesting students. We met President Obama, and then the MIT astronomy lab named minor planets after each of us,” Freed said of the competition.  

  19. WHK Interns Sweep Entire Category at Frederick County Science Fair | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer The competitors in the cellular and molecular biology category of the Frederick County Science and Engineering Fair on March 22–23 didn’t stand a chance against the Werner H. Kirsten student interns at the National Cancer Institute at Frederick. These interns swept the entire category, with Madelyne Xiao, a rising intern, winning first place; Maria Hamscher, second place; Ashley Babyak and Dahlia Kronfli tying for third place; and Maham Ahmed receiving an honorable mention.

  20. Five meter magnetic spectrometer based on a streamer chamber

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bohm, G.; Vertogradov, L.S.; Grishkevich, Ya.V.

    1972-01-01

    In streamer chamber technology. Development of a five-meter magnetic spectrometer, based on a streamer chamber with a liquid hydrogen target is outlined. The spectrometer is called RISK (Relativistic Ionization Streamer Chamber (Kamera)) because it is proposed to measure the velocity of relativistic particles by means of their ionization energy loss as an aid in their identification. The spectrometer will be used for the study of high-energy hadron interactions at the Serpukhov Synchrotron. The status of the project is summarized. (WHK)

  1. Intellectual Disabilities and Neglectful Parenting: Preliminary Findings on the Role of Cognition in Parenting Risk

    PubMed Central

    Azar, Sandra T.; Stevenson, Michael T.; Johnson, David R.

    2014-01-01

    Parents with intellectual disabilities (PID) are over-represented in the child protective services (CPS) system. This study examined a more nuanced view of the role of cognition in parenting risk. Its goal was to validate a social information processing (SIP) model of child neglect that draws on social cognition research and advances in neuroscience. Mothers who had CPS child neglect cases were compared with mothers with no CPS involvement on a set of SIP factors. Mothers with low IQs were oversampled. As predicted, the Neglect group had significantly greater SIP problems than the Comparison mothers. SIP problems were associated with direct measures of neglect (e.g., cognitive stimulation provided children, home hygiene, belief regarding causes of child injuries). Further, for the direct measures that were most closely linked to CPS Neglect Status, IQ did not add significant predictive capacity beyond SIP factors in preliminary model testing. Implications for intervention with PID discussed. PMID:25506405

  2. A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours.

    PubMed

    Mercado-Lubo, Regino; Zhang, Yuanwei; Zhao, Liang; Rossi, Kyle; Wu, Xiang; Zou, Yekui; Castillo, Antonio; Leonard, Jack; Bortell, Rita; Greiner, Dale L; Shultz, Leonard D; Han, Gang; McCormick, Beth A

    2016-07-25

    Salmonella enterica serotype Typhimurium is a food-borne pathogen that also selectively grows in tumours and functionally decreases P-glycoprotein (P-gp), a multidrug resistance transporter. Here we report that the Salmonella type III secretion effector, SipA, is responsible for P-gp modulation through a pathway involving caspase-3. Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin). On the basis of our finding that the SipA Salmonella effector is fundamental for functionally decreasing P-gp, we engineered a nanoparticle mimic that both overcomes multidrug resistance in cancer cells and increases tumour sensitivity to conventional chemotherapeutics.

  3. Solitary intracranial plasmacytoma located in the spheno-clival region mimicking chordoma: a case report.

    PubMed

    Liu, Z Y; Qi, X Q; Wu, X J; Luo, C; Lu, Y C

    2010-01-01

    Solitary intracranial plasmacytoma (SIP) is very rare. This case report presents serial findings of SIP located in the spheno-clival region in a 54-year old female who presented with an inferior hemianopia in the right eye and an enlarged physiological blind spot in both eyes. Based on the initial diagnosis of a spheno-clival region chordoma, the tumour was partially resected by the nasal-sphenoidal sinus approach. Subsequently, the correct diagnosis of SIP was made based on the pathology and immunohistochemical staining of the tumour. The patient was treated using a whole skull-base radiation therapy protocol with 45 Gy and she was in good physical condition during the subsequent 22 months. The findings of a series of similar case reports documenting SIP in 20 cases published from 1976 to 2008 are also reviewed. Based on these case reports, the key features of SIP, including their clinical manifestations, clinical imaging characteristics, treatment and prognosis, are described.

  4. Development of a monoclonal-based enzyme-linked immunoassay for saxitoxin-induced protein.

    PubMed

    Smith, D S; Kitts, D D

    1994-03-01

    A monoclonal antibody was generated against saxitoxin-induced protein (SIP) from the small shore crab Hemigrapsus oregenesis. SIP was induced by saxitoxin injection and could be detected in the crude crab extracts with both polyclonal and monoclonal antibody preparations. On Western blots, the polyclonal serum reacted against several bands which were induced by saxitoxin in the crude extracts. These bands represented proteins related to SIP. The monoclonal (4G5), however, was specific for the 79,000 mol. wt subunit of SIP. A triple antibody sandwich ELISA was developed in which polyclonal anti-SIP IgG was used as a trapping layer and monoclonal 4G5 was used as the detection layer. This assay was shown to be more specific and more accurate than a direct bind assay which employed the polyclonal antiserum alone. Although the polyclonal serum was more sensitive than the monoclonal on Western blots, the triple antibody sandwich and direct bind ELISAs were of comparable sensitivity.

  5. Consolidated Navy-Marines Environmental Law Deskbook. Revised

    DTIC Science & Technology

    1994-05-01

    106 ????? 1505 (1992)) FGD Flue Gas Desulfurization FGS Final Governing Standards FICUN Federal Interagency Committee on Urban Noise FIFRA Federal...SIPs. A. SIP management. Each SIP must be approved by EPA and must contain a mix of controls and strategies sufficient to achieve and maintain the...and contain release. Identify the parties carrying out response. If none, state why. EXAMPLE: Gas barriers used to control and contain vapor emissions

  6. Spectral inversion of frequency-domain IP data obtained in Haenam, South Korea

    NASA Astrophysics Data System (ADS)

    Kim, B.; Nam, M. J.; Son, J. S.

    2017-12-01

    Spectral induced polarization (SIP) method using a range of source frequencies have been performed for not only exploring minerals resources, but also engineering or environmental application. SIP interpretation first makes inversion of individual frequency data to obtain complex resistivity structures, which will further analyzed employing Cole-Cole model to explain the frequency-dependent characteristics. However, due to the difficulty in fitting Cole-Cole model, there is a movement to interpret complex resistivity structure inverted only from a single frequency data: that is so-called "complex resistivity survey". Further, simultaneous inversion of multi-frequency SIP data, rather than making a single frequency SIP data, has been studied to improve ambiguity and artefacts of independent single frequency inversion in obtaining a complex resistivity structure, even though the dispersion characteristics of complex resistivity with respect to source frequency. Employing the simultaneous inversion method, this study makes inversion of field SIP data obtained over epithermal mineralized area, Haenam, in the southernmost tip of South Korea. The area has a polarizable structure because of extensive hydrothermal alteration, gold-silver deposits. After the inversion, we compare between inversion results considering multi-frequency data and single frequency data set to evaluate the performance of simultaneous inversion of multi-frequency SIP data.

  7. Induced Polarization Signature of Biofilms in Porous Media: From Laboratory Experiments to Theoretical Developments and Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Atekwana, Estella; Patrauchan, Marianna; Revil, Andre

    2016-10-04

    Bioremediation strategies for mitigating the transport of heavy metals and radionuclides in subsurface sediments have largely targeted the use of dissimilatory metal and sulfate-reducing bacteria. Growth and metabolic activities from these organisms can significantly influence biogeochemical processes, including mineral dissolution/precipitation, fluctuating pH and redox potential (Eh) values, development of biofilms, and decreasing hydraulic conductivity. The Spectral Induced Polarization (SIP) technique has emerged as the technique most sensitive to the presence of microbial cells and biofilms in porous media; yet it is often difficult to unambiguously distinguish the impact of multiple and often competing processes that occur during in-situ biostimulation activitiesmore » on the SIP signatures. The main goal of our project is to quantitatively characterize major components within bacterial biofilms (cells, DNA, metals, metabolites etc.) contributing to detectable SIP signatures. We specifically: (i) evaluated the contribution of biofilm components to SIP signatures, (ii) determined the contribution of biogenic minerals commonly found in biofilms to SIP signatures, (iii) determined if the SIP signatures can be used to quantify the rates of biofilm formation, (iv) developed models and a fundamental understanding of potential underlying polarization mechanisms at low frequencies (<40 kHz) resulting from the presence of microbial cells and biofilms« less

  8. The shoulder pain and disability index: the construct validity and responsiveness of a region-specific disability measure.

    PubMed

    Heald, S L; Riddle, D L; Lamb, R L

    1997-10-01

    The purposes of this study were (1) to assess the construct validity of the Shoulder Pain and Disability Index (SPADI) and (2) to determine whether the SPADI is more responsive than the Sickness Impact Profile (SIP), a generic health status measure. The sample consisted of 94 patients who were diagnosed with a shoulder problem and referred to six outpatient physical therapy clinics. Clinically meaningful change was determined by use of an ordinal rating scale designed to determine whether the patient's shoulder function was improved, the same, or worse following treatment. Spearman rho correlations were calculated for the initial visit SPADI and SIP scores. The standardized response mean (SRM) was used to measure responsiveness for the patients who were judged to be improved. One-tailed paired t tests (alpha = .01) were used to determine whether differences existed among SRM values. Correlations between the SPADI and SIP scores ranged from r = .01 to r = .57. The SRM value was higher for the SPADI total score (SRM = 1.38) than for the SIP total score (SRM = 0.79). Most correlations between SPADI and SIP scores provided support for the construct validity of the SPADI. The SPADI does not appear to strongly reflect occupational and recreational disability and is more responsive than the SIP.

  9. Surface modification of silicon wafer by grafting zwitterionic polymers to improve its antifouling property

    NASA Astrophysics Data System (ADS)

    Sun, Yunlong; Chen, Changlin; Xu, Heng; Lei, Kun; Xu, Guanzhe; Zhao, Li; Lang, Meidong

    2017-10-01

    Silicon (111) wafer was modified by triethoxyvinylsilane containing double bond as an intermedium, and then P4VP (polymer 4-vinyl pyridine) brush was "grafted" onto the surface of silicon wafer containing reactive double bonds by adopting the "grafting from" way and Si-P4VP substrate (silicon wafer grafted by P4VP) was obtained. Finally, P4VP brush of Si-P4VP substrate was modified by 1,3-propanesulfonate fully to obtain P4VP-psl brush (zwitterionic polypyridinium salt) and the functional Si-P4VP-psl substrate (silicon wafer grafted by zwitterionic polypyridinium salt based on polymer 4-vinyl pyridine) was obtained successfully. The antifouling property of the silicon wafer, the Si-P4VP substrate and the Si-P4VP-psl substrate was investigated by using bovine serum albumin, mononuclear macrophages (RAW 264.7) and Escherichia coli (E. coli) ATTC25922 as model bacterium. The results showed that compared with the blank sample-silicon wafer, the Si-P4VP-psl substrate had excellent anti-adhesion ability against bovine serum albumin, cells and bacterium, due to zwitterionic P4VP-psl brush (polymer 4-vinyl pyridine salt) having special functionality like antifouling ability on biomaterial field.

  10. Computational methods using weighed-extreme learning machine to predict protein self-interactions with protein evolutionary information.

    PubMed

    An, Ji-Yong; Zhang, Lei; Zhou, Yong; Zhao, Yu-Jun; Wang, Da-Fu

    2017-08-18

    Self-interactions Proteins (SIPs) is important for their biological activity owing to the inherent interaction amongst their secondary structures or domains. However, due to the limitations of experimental Self-interactions detection, one major challenge in the study of prediction SIPs is how to exploit computational approaches for SIPs detection based on evolutionary information contained protein sequence. In the work, we presented a novel computational approach named WELM-LAG, which combined the Weighed-Extreme Learning Machine (WELM) classifier with Local Average Group (LAG) to predict SIPs based on protein sequence. The major improvement of our method lies in presenting an effective feature extraction method used to represent candidate Self-interactions proteins by exploring the evolutionary information embedded in PSI-BLAST-constructed position specific scoring matrix (PSSM); and then employing a reliable and robust WELM classifier to carry out classification. In addition, the Principal Component Analysis (PCA) approach is used to reduce the impact of noise. The WELM-LAG method gave very high average accuracies of 92.94 and 96.74% on yeast and human datasets, respectively. Meanwhile, we compared it with the state-of-the-art support vector machine (SVM) classifier and other existing methods on human and yeast datasets, respectively. Comparative results indicated that our approach is very promising and may provide a cost-effective alternative for predicting SIPs. In addition, we developed a freely available web server called WELM-LAG-SIPs to predict SIPs. The web server is available at http://219.219.62.123:8888/WELMLAG/ .

  11. Squid ink polysaccharide prevents autophagy and oxidative stress affected by cyclophosphamide in Leydig cells of mice: a pilot study

    PubMed Central

    Gu, Yi-Peng; Yang, Xiao-Mei; Duan, Zhen-Hua; Shang, Jiang-Hua; Luo, Ping; Xiao, Wei; Zhang, Da-Yan; Liu, Hua-Zhong

    2017-01-01

    Objective(s): The aim of this study was to explore the effects of Squid ink polysaccharide (SIP) on prevention of autophagy and oxidative stress induced by cyclophosphamide (CP) in Leydig cells of mice. Materials and Methods: Examination of reproductive organ exponents, abnormal sperm rate, activities of superoxide dismutase (SOD), catalase (CAT), contents of malondialdehyde (MDA), and histological structure were performed to detect the optimal dose of SIP against oxidative stress damage in vivo, and autophagy-associated protein LC3 and Beclin-1 were examined by immunofluorescence, and their expression was detected by Western blot analysis. Leydig cells ultrastructural changes were observed by transmission fluorescent microscope. Results: SIP significantly inhibited sperm aberration, histological structure and injury of seminiferous tubules caused by CP, as well as the antioxidant activity of SOD and CAT were increased; contents of MDA were decreased. The optimal dose of SIP for prevention of oxidative stress injury by CP was 80 mg/kg. In addition, LC3 and Beclin-1 fluorescent granules were much less in the Leydig cell layer after treatment via SIP compared with the CP-treated group, and the expression levels of LC3 and Beclin-1 were also decreased. Furthermore, characteristics of cell autophagy such as mitochondrial swelling, autophagic vacuoles, and chromatin pyknosis were observed in CP-treated Leydig cells, but SIP could effectively weaken injury of Leydig cell ultrastructure by CP. Conclusion: SIP, as an antioxidant, prevents the cytoskeleton damage through up-regulation antioxidant capacity and inhibition autophagy caused by CP. PMID:29299195

  12. Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins

    PubMed Central

    Conidi, Andrea; van den Berghe, Veronique; Leslie, Kris; Stryjewska, Agata; Xue, Hua; Chen, Ye-Guang; Seuntjens, Eve; Huylebroeck, Danny

    2013-01-01

    The zinc finger transcription factor Smad-interacting protein-1 (Sip1; Zeb2, Zfhx1b) plays an important role during vertebrate embryogenesis in various tissues and differentiating cell types, and during tumorigenesis. Previous biochemical analysis suggests that interactions with several partner proteins, including TGFβ family receptor-activated Smads, regulate the activities of Sip1 in the nucleus both as a DNA-binding transcriptional repressor and activator. Using a peptide aptamer approach we mapped in Sip1 its Smad-binding domain (SBD), initially defined as a segment of 51 amino acids, to a shorter stretch of 14 amino acids within this SBD. Modelling suggests that this short SBD stretch is part of an extended α-helix that may fit the binding to a hydrophobic corridor within the MH2 domain of activated Smads. Four amino acids (two polar Q residues and two non-polar V residues) that form the tandem repeat (QxVx)2 in this 14-residue stretch were found to be crucial for binding to both TGFβ/Nodal/Activin-Smads and BMP-Smads. A full-length Sip1 with collective mutation of these Q and V residues (to A) no longer binds to Smads, while it retains its binding activity to its cognate bipartite target DNA sequence. This missense mutant Sip1(AxAx)2 provides a new molecular tool to identify SBD (in)dependent target genes in Sip1-controlled TGFβ and/or BMP (de)regulated cellular, developmental and pathological processes. PMID:24146916

  13. Schedule-induced polydipsia is associated with increased spine density in dorsolateral striatum neurons.

    PubMed

    Íbias, J; Soria-Molinillo, E; Kastanauskaite, A; Orgaz, C; DeFelipe, J; Pellón, R; Miguéns, M

    2015-08-06

    Schedule-induced polydipsia (SIP) is an adjunctive behavior in which rats exhibit excessive drinking as a consequence of intermittent feeding, and it has been proposed as a candidate model to study the development of compulsive and repetitive behavior. Although several brain structures are involved in compulsive behavior, it has been suggested that alterations in fronto-striatal circuits may underlie compulsive spectrum disorders. In the present work, we examined whether SIP would induce modifications in dorsolateral striatum (DLS) and anterior prefrontal cortex (aPFC) neurons. Specifically, the effects of 20 sessions of SIP were determined in the dendrites of DLS medium spiny neurons and in the basal dendritic arbors of layer V pyramidal cells in the aPFC. The structure, size and branching complexity in aPFC neurons were also studied. Results showed that SIP resulted in an increase in dendritic spine density in DLS neurons. Moreover, dendritic spine density was highly correlated with the level of drinking in animals subjected to SIP. By contrast, we observed no differences either in dendritic spine density or in the morphological structure of the dendrites of the aPFC in SIP rats compared to their control counterparts. We hypothesize that SIP-induced structural plasticity in DLS neurons could be related to inflexible response in compulsive behavior. The findings of this study could provide new insights into the involvement of particular cell populations of the dorsolateral striatum and anterior prefrontal cortex regions in compulsive spectrum disorders. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  14. Domain Specificity in Relationship History, Social-Information Processing, and Violent Behavior in Early Adulthood

    PubMed Central

    Pettit, Gregory S.; Lansford, Jennifer E.; Malone, Patrick S.; Dodge, Kenneth A.; Bates, John E.

    2013-01-01

    Using prospective longitudinal data, we tested 5 hypotheses: (a) that the relation between earlier developmental experiences (peer social rejection and victimization in a romantic relationship) and adult violent behavior toward peers and romantic partners is specific to relationship domain; (b) that the relation between social-information processing (SIP) biases and subsequent violence is also specific to relational domain (romantic partner vs. peer); (c) that the relation between developmental experiences and SIP biases is domain specific; (d) that domain-specific SIP mediates the impact of earlier developmental experiences on later violent behavior; and (e) that harsh parenting early in life is a domain-general predictor of SIP and later violent behavior. Harsh parenting was assessed through interviews with parents when their children were age 5 years. Classroom sociometric assessments indexing peer rejection were completed in elementary school, and self-report of victimization by romantic partners was provided at age 18 years. SIP was assessed via interview at age 22 years, and violent behavior was measured via self-and partner report at ages 23 years and 24 years. Structural equation analyses revealed specificity in the relation between developmental experiences and violence and in the prediction to and from SIP in the peer domain, but not in the romantic-relationship domain. The impact of early harsh treatment on violence toward peers was mediated by SIP biases in the peer domain. These findings provide support for domain specificity in the peer domain but for cross-domain generality in the romantic relationship domain in the development of violent behavior in early adulthood. PMID:20085394

  15. 77 FR 14603 - Approval and Promulgation of Implementation Plans; Arkansas; Regional Haze State Implementation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ...The EPA is partially approving and partially disapproving a revision to the Arkansas State Implementation Plan (SIP) intended to address the regional haze (RH) requirements of the Clean Air Act (CAA or Act). In addition, EPA is partially approving and partially disapproving the portion of the Arkansas Interstate Transport SIP submittal that addresses the visibility requirement of section 110(a)(2)(D)(i)(II) for the 1997 8-hour ozone and 1997 fine particulate matter (PM2.5) national ambient air quality standards (NAAQS) that the Arkansas SIP contain adequate provisions to prohibit emissions from interfering with measures required in another state to protect visibility. EPA is approving certain core elements of the RH SIP including: identification of affected Class I areas; determination of baseline and natural visibility conditions; determination of Uniform Rate of Progress (URP); reasonable progress goal (RPG) consultation and long term strategy (LTS) consultation; coordination of RH and reasonably attributable visibility impairment (RAVI); regional haze monitoring strategy and other SIP requirements under 40 CFR 51.308(d)(4); commitment to submit periodic regional haze SIP revisions and periodic progress reports describing progress towards the RPGs; commitment to make a determination of the adequacy of the existing SIP at the time a progress report is submitted; and consultation and coordination with Federal land managers (FLMs). EPA is partially approving and partially disapproving portions of other core elements of the SIP including: identification of best available retrofit technology (BART) eligible sources and subject to BART sources; requirements for BART; Chapter 15 of the Air Pollution Control and Ecology Commission (APCEC) Regulation No. 19, also known as the State's RH Rule; and the LTS. EPA is disapproving Arkansas's reasonable progress goals (RPGs) required under 40 CFR 51.308(d)(1). This action is being taken under section 110 and part C of the CAA.

  16. Ventilatory muscle endurance training in quadriplegia: effects on breathing pattern.

    PubMed

    Loveridge, B; Badour, M; Dubo, H

    1989-10-01

    We examined the effects of ventilatory muscle endurance training on resting breathing pattern in 12 C6-C7 traumatic quadriplegics at least 1 year post-injury. All subjects had complete motor loss below the lesion level. Subjects were randomly assigned to a training (N = 6), or a control group (N = 6). Baseline tests included measurement of resting ventilation and breathing pattern using mercury in rubber strain gauges for 20 minutes in a seated position; maximum inspiratory mouth pressure (MIP) at FRC, and sustainable inspiratory mouth pressure for 10 minutes (SIP); lung volumes, and arterial blood gases (ABG's). The training protocol consisted of breathing through an inspiratory resistor equivalent to 85% SIP for 15 minutes twice daily, 5 days a week for 8 weeks. Both trainers and controls attended the lab every 2 weeks for reassessment of MIP and SIP and the inspiratory resistance was increased in the training group as SIP increased. At the end of 8 weeks, baseline tests were repeated. All subjects had normal ABG's. There was a significant increase in mean MIP and SIP in both the control group (30% +/- 19% and 31% +/- 18% respectively), and in the training group (42% +/- 24% and 78% +/- 49% respectively). Although the absolute values for both MIP and SIP were greater in the training group than in the control group, the differences were not significant. The alterations in resting breathing pattern were also the same in both groups. Mean frequency decreased significantly in the control group (20.2/minute to 16.9/minute) and, while insignificant, the change in frequency in the training group was the same, 19.4/minute to 16.4/minute. Mean tidal volume (Vt) increased 18.2% of baseline Vt in the control group and 17.0% baseline in the trainers, resulting in no change in minute ventilation. As MIP and SIP increased similarly in both groups, the data from the control and trainers was pooled and timing changes re-evaluated pre- and post-study. A significant decrease in mean Ti/Ttot was observed, while no change in Vt/Ti was found. We concluded that the testing procedure itself provided the stimulus resulting in a significant increase in MIP and SIP. The addition of training did not increase MIP and SIP further. The increased MIP and SIP resulted in a slower and deeper breathing pattern and a significantly shorter Ti/Ttot in both trainers and control subjects.

  17. A Secured Authentication Protocol for SIP Using Elliptic Curves Cryptography

    NASA Astrophysics Data System (ADS)

    Chen, Tien-Ho; Yeh, Hsiu-Lien; Liu, Pin-Chuan; Hsiang, Han-Chen; Shih, Wei-Kuan

    Session initiation protocol (SIP) is a technology regularly performed in Internet Telephony, and Hyper Text Transport Protocol (HTTP) as digest authentication is one of the major methods for SIP authentication mechanism. In 2005, Yang et al. pointed out that HTTP could not resist server spoofing attack and off-line guessing attack and proposed a secret authentication with Diffie-Hellman concept. In 2009, Tsai proposed a nonce based authentication protocol for SIP. In this paper, we demonstrate that their protocol could not resist the password guessing attack and insider attack. Furthermore, we propose an ECC-based authentication mechanism to solve their issues and present security analysis of our protocol to show that ours is suitable for applications with higher security requirement.

  18. Monitoring microbial growth and activity using spectral induced polarization and low-field nuclear magnetic resonance

    NASA Astrophysics Data System (ADS)

    Zhang, Chi; Keating, Kristina; Revil, Andre

    2015-04-01

    Microbes and microbial activities in the Earth's subsurface play a significant role in shaping subsurface environments and are involved in environmental applications such as remediation of contaminants in groundwater and oil fields biodegradation. Stimulated microbial growth in such applications could cause wide variety of changes of physical/chemical properties in the subsurface. It is critical to monitor and determine the fate and transportation of microorganisms in the subsurface during such applications. Recent geophysical studies demonstrate the potential of two innovative techniques, spectral induced polarization (SIP) and low-field nuclear magnetic resonance (NMR), for monitoring microbial growth and activities in porous media. The SIP measures complex dielectric properties of porous media at low frequencies of exciting electric field, and NMR studies the porous structure of geologic media and characterizes fluids subsurface. In this laboratory study, we examined both SIP and NMR responses from bacterial growth suspension as well as suspension mixed with silica sands. We focus on the direct contribution of microbes to the SIP and NMR signals in the absence of biofilm formation or biomineralization. We used Zymomonas mobilis and Shewanella oneidensis (MR-1) for SIP and NMR measurements, respectively. The SIP measurements were collected over the frequency range of 0.1 - 1 kHz on Z. mobilis growth suspension and suspension saturated sands at different cell densities. SIP data show two distinct peaks in imaginary conductivity spectra, and both imaginary and real conductivities increased as microbial density increased. NMR data were collected using both CPMG pulse sequence and D-T2 mapping to determine the T2-distribution and diffusion properties on S. oneidensis suspension, pellets (live and dead), and suspension mixed with silica sands. NMR data show a decrease in the T2-distribution in S. oneidensis suspension saturated sands as microbial density increase. A clear distinction in the T2-distribution and D-T2 plots between live and dead cell pellets was also observed. These results will provide a basis for understanding the effect of microbes within geologic media on SIP and low-field NMR measurements. This research suggests that both SIP and NMR have the potential to monitor microbial growth and activities in the subsurface and could provide spatiotemporal variations in bacterial abundance in porous media.

  19. Application of Short Screening Tools for Post-Traumatic Stress Disorder in the Korean Elderly Population

    PubMed Central

    Jang, Yu Jin; Chung, Hae Gyung; Choi, Jin Hee; Kim, Tae Yong; So, Hyung Seok

    2016-01-01

    Objective Post-traumatic stress disorder (PTSD) is often missed or incorrectly diagnosed in primary care settings. Although brief screening instruments may be useful in detecting PTSD, an adequate validation study has not been conducted with older adults. This study aimed to evaluate the reliability and validity of the Korean version of the primary care PTSD screen (PC-PTSD) and single-item PTSD screener (SIPS) in elderly veterans. Methods The PC-PTSD and SIPS assessments were translated into Korean, with a back-translation to the original language to verify accuracy. Vietnamese war veterans [separated into a PTSD group (n=41) and a non-PTSD group (n=99)] participated in several psychometric assessments, including the Korean versions of the PC-PTSD (PC-PTSD-K), SIPS (SIPS-K), a structured clinical interview from the Diagnostic and Statistical Manual of Mental Disorders-IV(SCID), and PTSD checklist(PCL). Results The PC-PTSD-K showed high internal consistency (Cronbach α=0.76), and the test-retest reliability of the PC-PTSD-K and SIPS-K were also high (r=0.97 and r=0.91, respectively). A total score of 3 from the PC-PTSD-K yielded the highest diagnostic efficiency, with sensitivity and specificity values of 0.90 and 0.86, respectively. The 'bothered a lot' response level from the SIPS-K showed the highest diagnostic efficiency, with sensitivity and specificity values of 0.85 and 0.89, respectively. Conclusion Our findings suggest that both PC-PTSD-K and SIPS-K have good psychometric properties with high validity and reliability for detecting PTSD symptoms in elderly Korean veterans. However, further research will be necessary to increase our understanding of PTSD characteristics in diverse groups with different types of trauma. PMID:27482241

  20. The Early Psychosis Screener (EPS): Quantitative validation against the SIPS using machine learning.

    PubMed

    Brodey, B B; Girgis, R R; Favorov, O V; Addington, J; Perkins, D O; Bearden, C E; Woods, S W; Walker, E F; Cornblatt, B A; Brucato, G; Walsh, B; Elkin, K A; Brodey, I S

    2018-01-18

    Machine learning techniques were used to identify highly informative early psychosis self-report items and to validate an early psychosis screener (EPS) against the Structured Interview for Psychosis-risk Syndromes (SIPS). The Prodromal Questionnaire-Brief Version (PQ-B) and 148 additional items were administered to 229 individuals being screened with the SIPS at 7 North American Prodrome Longitudinal Study sites and at Columbia University. Fifty individuals were found to have SIPS scores of 0, 1, or 2, making them clinically low risk (CLR) controls; 144 were classified as clinically high risk (CHR) (SIPS 3-5) and 35 were found to have first episode psychosis (FEP) (SIPS 6). Spectral clustering analysis, performed on 124 of the items, yielded two cohesive item groups, the first mostly related to psychosis and mania, the second mostly related to depression, anxiety, and social and general work/school functioning. Items within each group were sorted according to their usefulness in distinguishing between CLR and CHR individuals using the Minimum Redundancy Maximum Relevance procedure. A receiver operating characteristic area under the curve (AUC) analysis indicated that maximal differentiation of CLR and CHR participants was achieved with a 26-item solution (AUC=0.899±0.001). The EPS-26 outperformed the PQ-B (AUC=0.834±0.001). For screening purposes, the self-report EPS-26 appeared to differentiate individuals who are either CLR or CHR approximately as well as the clinician-administered SIPS. The EPS-26 may prove useful as a self-report screener and may lead to a decrease in the duration of untreated psychosis. A validation of the EPS-26 against actual conversion is underway. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. The role of groundwater discharge fluxes on Si:P ratios in a major tributary to Lake Erie.

    PubMed

    Maavara, Taylor; Slowinski, Stephanie; Rezanezhad, Fereidoun; Van Meter, Kimberly; Van Cappellen, Philippe

    2018-05-01

    Groundwater discharge can be a major source of nutrients to river systems. Although quantification of groundwater nitrate loading to streams is common, the dependence of surface water silicon (Si) and phosphorus (P) concentrations on groundwater sources has rarely been determined. Additionally, the ability of groundwater discharge to drive surface water Si:P ratios has not been contextualized relative to riverine inputs or in-stream transformations. In this study, we quantify the seasonal dynamics of Si and P cycles in the Grand River (GR) watershed, the largest Canadian watershed draining into Lake Erie, to test our hypothesis that regions of Si-rich groundwater discharge increase surface water Si:P ratios. Historically, both the GR and Lake Erie have been considered stoichiometrically P-limited, where the molar Si:P ratio is greater than the ~16:1 phytoplankton uptake ratio. However, recent trends suggest that eastern Lake Erie may be approaching Si-limitation. We sampled groundwater and surface water for dissolved and reactive particulate Si as well as total dissolved P for 12months within and downstream of a 50-km reach of high groundwater discharge. Our results indicate that groundwater Si:P ratios are lower than the corresponding surface water and that groundwater is a significant source of bioavailable P to surface water. Despite these observations, the watershed remains P-limited for the majority of the year, with localized periods of Si-limitation. We further find that groundwater Si:P ratios are a relatively minor driver of surface water Si:P, but that the magnitude of Si and P loads from groundwater represent a large proportion of the overall fluxes to Lake Erie. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. High-level expression of nattokinase in Bacillus licheniformis by manipulating signal peptide and signal peptidase.

    PubMed

    Cai, D; Wei, X; Qiu, Y; Chen, Y; Chen, J; Wen, Z; Chen, S

    2016-09-01

    Nattokinase is an enzyme produced by Bacillus licheniformis and has potential to be used as a drug for treating cardiovascular disease due to its beneficial effects of preventing fibrin clots etc. However, the low activity and titre of this protein produced by B. licheniformis often hinders its application of commercial production. The aim of this work is to improve the nattokinase production by manipulating signal peptides and signal peptidases in B. licheniformis. The P43 promoter, amyL terminator and AprN target gene were used to form the nattokinase expression vector, pHY-SP-NK, which was transformed into B. licheniformis and nattokinase was expressed successfully. A library containing 81 predicted signal peptides was constructed for nattokinase expression in B. licheniformis, with the maximum activity being obtained under the signal peptide of AprE. Among four type I signal peptidases genes (sipS, sipT, sipV, sipW) in B. licheniformis, the deletion of sipV resulted in a highest decrease in nattokinase activity. Overexpression of sipV in B. licheniformis led to a nattokinase activity of 35·60 FU ml(-1) , a 4·68-fold improvement over activity produced by the initial strain. This work demonstrates the potential of B. licheniformis for industrial production of nattokinase through manipulation of signal peptides and signal peptidases expression. This study has screened the signal peptides of extracellular proteins of B. licheniformis for nattokinase production. Four kinds of Type I signal peptidases genes have been detected respectively in B. licheniformis to identify which one played the vital role for nattokinase production. This study provided a promising strain for industry production of nattokinase. © 2016 The Society for Applied Microbiology.

  3. Indicator Expansion with Analysis Pipeline

    DTIC Science & Technology

    2015-01-13

    INTERNAL FILTER trackInfectedHosts FILTER badTraffic SIP infectedHosts 1 DAY END INTERNAL FILTER 11 Step 3 watch where infected hosts go FILTER...nonWhiteListPostInfected SIP IN LIST infectedHosts DIP NOT IN LIST safePopularIPs.set END FILTER 12 Step 4 & 5: Count Hosts Per IP and Alert EVALUATION...CHECK THRESHOLD DISTINCT SIP > 50 TIME WINDOW 36 HOURS END CHECK END EVALUATION 13 Step 6: Report Expanded Indicators LIST CONFIGURATION secondLevelIPs

  4. [Formula: see text]Executive functions and social information processing in adolescents with severe behavior problems.

    PubMed

    Van Nieuwenhuijzen, M; Van Rest, M M; Embregts, P J C M; Vriens, A; Oostermeijer, S; Van Bokhoven, I; Matthys, W

    2017-02-01

    One tradition in research for explaining aggression and antisocial behavior has focused on social information processing (SIP). Aggression and antisocial behavior have also been studied from the perspective of executive functions (EFs), the higher-order cognitive abilities that affect other cognitive processes, such as social cognitive processes. The main goal of the present study is to provide insight into the relation between EFs and SIP in adolescents with severe behavior problems. Because of the hierarchical relation between EFs and SIP, we examined EFs as predictors of SIP. We hypothesized that, first, focused attention predicts encoding and interpretation, second, inhibition predicts interpretation, response generation, evaluation, and selection, and third, working memory predicts response generation and selection. The participants consisted of 94 respondents living in residential facilities aged 12-20 years, all showing behavior problems in the clinical range according to care staff. EFs were assessed using subtests from the Amsterdam Neuropsychological Test battery. Focused attention was measured by the Flanker task, inhibition by the GoNoGo task, and working memory by the Visual Spatial Sequencing task. SIP was measured by video vignettes and a structured interview. The results indicate that positive evaluation of aggressive responses is predicted by impaired inhibition and selection of aggressive responses by a combination of impaired focused attention and inhibition. It is concluded that different components of EFs as higher-order cognitive abilities affect SIP.

  5. Preparation and evaluation of squid ink polysaccharide-chitosan as a wound-healing sponge.

    PubMed

    Huang, Na; Lin, Jiali; Li, Sidong; Deng, Yifeng; Kong, Songzhi; Hong, Pengzhi; Yang, Ping; Liao, Mingneng; Hu, Zhang

    2018-01-01

    A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS). The optimized formulation of SIP-CS was as follows: chitosan concentration, 2.29%; squid ink polysaccharide concentration, 0.55%; and calcium chloride concentration, 2.82%, at a volume ratio of 15:5:2. SIP-CS was conducive to sticking on the wound, characterized by the spongy property, strong absorptivity, and tackiness. Rabbit ear arterial, hepatic, and femoral artery hemorrhage experiments indicated that, compared with chitosan dressings and absorbable gelatin, the hemostatic times were shorter and the bleeding volume was smaller. Furthermore, SIP-CS absorbed a large amount of hemocytes, leading to rapid hemostasis. The healing areas and wound pathological sections in scalded New Zealand rabbits indicated that SIP-CS promoted wound healing more rapidly than chitosan and better than commercially available burn cream. Thus, SIP-CS is a good wound healing agent for rapid hemostasis, promoting burn/scalded skin healing, and protecting from wound infection. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Characterization of the Interaction between the Salmonella Type III Secretion System Tip Protein SipD and the Needle Protein PrgI by Paramagnetic Relaxation Enhancement*

    PubMed Central

    Rathinavelan, Thenmalarchelvi; Tang, Chun; De Guzman, Roberto N.

    2011-01-01

    Many Gram-negative bacteria that cause major diseases and mortality worldwide require the type III secretion system (T3SS) to inject virulence proteins into their hosts and cause infections. A structural component of the T3SS is the needle apparatus, which consists of a base, an external needle, and a tip complex. In Salmonella typhimurium, the external needle is assembled by the polymerization of the needle protein PrgI. On top of this needle sits a tip complex, which is partly formed by the tip protein SipD. How SipD interacts with PrgI during the assembly of the T3SS needle apparatus remains unknown. The central region of PrgI forms an α-helical hairpin, whereas SipD has a long central coiled-coil, which is a defining structural feature of other T3SS tip proteins as well. Using NMR paramagnetic relaxation enhancement, we have identified a specific region on the SipD coiled-coil that interacts directly with PrgI. We present a model of how SipD might dock at the tip of the needle based on our paramagnetic relaxation enhancement results, thus offering new insight about the mechanism of assembly of the T3SS needle apparatus. PMID:21138848

  7. Identification of Group B Streptococcal Sip Protein, Which Elicits Cross-Protective Immunity

    PubMed Central

    Brodeur, Bernard R.; Boyer, Martine; Charlebois, Isabelle; Hamel, Josée; Couture, France; Rioux, Clément R.; Martin, Denis

    2000-01-01

    A protein of group B streptococci (GBS), named Sip for surface immunogenic protein, which is distinct from previously described surface proteins, was identified after immunological screening of a genomic library. Immunoblots using a Sip-specific monoclonal antibody indicated that a protein band with an approximate molecular mass of 53 kDa which did not vary in size was present in every GBS strain tested. Representatives of all nine GBS serotypes were included in the panel of strains. Cloning and sequencing of the sip gene revealed an open reading frame of 1,305 nucleotides coding for a polypeptide of 434 amino acid residues, with a calculated pI of 6.84 and molecular mass of 45.5 kDa. Comparison of the nucleotide sequences from six different strains confirmed with 98% identity that the sip gene is highly conserved among GBS isolates. N-terminal amino acid sequencing also indicated the presence of a 25-amino-acid signal peptide which is cleaved in the mature protein. More importantly, immunization with the recombinant Sip protein efficiently protected CD-1 mice against deadly challenges with six GBS strains of serotypes Ia/c, Ib, II/R, III, V, and VI. The data presented in this study suggest that this highly conserved protein induces cross-protective immunity against GBS infections and emphasize its potential as a universal vaccine candidate. PMID:10992461

  8. A single sip of a strong alcoholic beverage causes exposure to carcinogenic concentrations of acetaldehyde in the oral cavity.

    PubMed

    Linderborg, Klas; Salaspuro, Mikko; Väkeväinen, Satu

    2011-09-01

    The aim of this study was to explore oral exposure to carcinogenic (group 1) acetaldehyde after single sips of strong alcoholic beverages containing no or high concentrations of acetaldehyde. Eight volunteers tasted 5 ml of ethanol diluted to 40 vol.% with no acetaldehyde and 40 vol.% calvados containing 2400 μM acetaldehyde. Salivary acetaldehyde and ethanol concentrations were measured by gas chromatography. The protocol was repeated after ingestion of ethanol (0.5 g/kg body weight). Salivary acetaldehyde concentration was significantly higher after sipping calvados than after sipping ethanol at 30s both with (215 vs. 128 μmol/l, p<0.05) and without (258 vs. 89 μmol/l, p<0.05) alcohol ingestion. From 2 min onwards there were no significant differences in the decreasing salivary acetaldehyde concentration, which remained above the level of carcinogenicity still at 10 min. The systemic alcohol distribution from blood to saliva had no additional effect on salivary acetaldehyde after sipping of the alcoholic beverages. Carcinogenic concentrations of acetaldehyde are produced from ethanol in the oral cavity instantly after a small sip of strong alcoholic beverage, and the exposure continues for at least 10 min. Acetaldehyde present in the beverage has a short-term effect on total acetaldehyde exposure. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Development and implementation of the Caribbean Laboratory Quality Management Systems Stepwise Improvement Process (LQMS-SIP) Towards Accreditation.

    PubMed

    Alemnji, George; Edghill, Lisa; Guevara, Giselle; Wallace-Sankarsingh, Sacha; Albalak, Rachel; Cognat, Sebastien; Nkengasong, John; Gabastou, Jean-Marc

    2017-01-01

    Implementing quality management systems and accrediting laboratories in the Caribbean has been a challenge. We report the development of a stepwise process for quality systems improvement in the Caribbean Region. The Caribbean Laboratory Stakeholders met under a joint Pan American Health Organization/US Centers for Disease Control and Prevention initiative and developed a user-friendly framework called 'Laboratory Quality Management System - Stepwise Improvement Process (LQMS-SIP) Towards Accreditation' to support countries in strengthening laboratory services through a stepwise approach toward fulfilling the ISO 15189: 2012 requirements. This approach consists of a three-tiered framework. Tier 1 represents the minimum requirements corresponding to the mandatory criteria for obtaining a licence from the Ministry of Health of the participating country. The next two tiers are quality improvement milestones that are achieved through the implementation of specific quality management system requirements. Laboratories that meet the requirements of the three tiers will be encouraged to apply for accreditation. The Caribbean Regional Organisation for Standards and Quality hosts the LQMS-SIP Secretariat and will work with countries, including the Ministry of Health and stakeholders, including laboratory staff, to coordinate and implement LQMS-SIP activities. The Caribbean Public Health Agency will coordinate and advocate for the LQMS-SIP implementation. This article presents the Caribbean LQMS-SIP framework and describes how it will be implemented among various countries in the region to achieve quality improvement.

  10. Early alcohol use with parental permission: Psychosocial characteristics and drinking in late adolescence.

    PubMed

    Colder, Craig R; Shyhalla, Kathleen; Frndak, Seth E

    2018-01-01

    The earliest experiences with alcohol for many children occur in the family context with parental supervision. The current study examined individual and sociocultural characteristics associated with early (prior to age 13years) sipping and tasting alcohol with parental permission in two longitudinal community samples. Early sipping/tasting was also tested as a predictor of frequency and quantity of alcohol use, and alcohol-related problems seven years later in late adolescence. Early sipping/tasting with parental permission was associated with a sociocultural context supportive of alcohol use (e.g., parental alcohol use, permissive rules about alcohol use in the home, parental attitudes about underage drinking, perceived peer norms), adolescent sensation seeking and disinhibition (e.g., surgency, externalizing behavior) and appraisals of alcohol (negative outcome expectancies and negative implicit alcohol associations). Early sipping/tasting predicted increased frequency and quantity of alcohol consumption, and increased alcohol-related problems in late adolescence, even after controlling sociocultural and individual difference variables. Findings suggest that early sipping/tasting with parental permission is not benign and is a viable target for preventive interventions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT

    PubMed Central

    Rogers, Crystal D.; Saxena, Ankur

    2013-01-01

    The neural crest, an embryonic stem cell population, initially resides within the dorsal neural tube but subsequently undergoes an epithelial-to-mesenchymal transition (EMT) to commence migration. Although neural crest and cancer EMTs are morphologically similar, little is known regarding conservation of their underlying molecular mechanisms. We report that Sip1, which is involved in cancer EMT, plays a critical role in promoting the neural crest cell transition to a mesenchymal state. Sip1 transcripts are expressed in premigratory/migrating crest cells. After Sip1 loss, the neural crest specifier gene FoxD3 was abnormally retained in the dorsal neuroepithelium, whereas Sox10, which is normally required for emigration, was diminished. Subsequently, clumps of adherent neural crest cells remained adjacent to the neural tube and aberrantly expressed E-cadherin while lacking N-cadherin. These findings demonstrate two distinct phases of neural crest EMT, detachment and mesenchymalization, with the latter involving a novel requirement for Sip1 in regulation of cadherin expression during completion of neural crest EMT. PMID:24297751

  12. The Spectral Image Processing System (SIPS) - Interactive visualization and analysis of imaging spectrometer data

    NASA Technical Reports Server (NTRS)

    Kruse, F. A.; Lefkoff, A. B.; Boardman, J. W.; Heidebrecht, K. B.; Shapiro, A. T.; Barloon, P. J.; Goetz, A. F. H.

    1993-01-01

    The Center for the Study of Earth from Space (CSES) at the University of Colorado, Boulder, has developed a prototype interactive software system called the Spectral Image Processing System (SIPS) using IDL (the Interactive Data Language) on UNIX-based workstations. SIPS is designed to take advantage of the combination of high spectral resolution and spatial data presentation unique to imaging spectrometers. It streamlines analysis of these data by allowing scientists to rapidly interact with entire datasets. SIPS provides visualization tools for rapid exploratory analysis and numerical tools for quantitative modeling. The user interface is X-Windows-based, user friendly, and provides 'point and click' operation. SIPS is being used for multidisciplinary research concentrating on use of physically based analysis methods to enhance scientific results from imaging spectrometer data. The objective of this continuing effort is to develop operational techniques for quantitative analysis of imaging spectrometer data and to make them available to the scientific community prior to the launch of imaging spectrometer satellite systems such as the Earth Observing System (EOS) High Resolution Imaging Spectrometer (HIRIS).

  13. NASA SNPP SIPS - Following in the Path of EOS

    NASA Technical Reports Server (NTRS)

    Behnke, Jeanne; Hall, Alfreda; Ho, Evelyn

    2016-01-01

    NASA's Earth Science Data Information System (ESDIS) Project has been operating NASA's Suomi National Polar-Orbiting Partnership (SNPP) Science Data Segment (SDS) since the launch in October 2011. At launch, the SDS focused primarily on the evaluation of Sensor Data Records (SDRs) and Environmental Data Records (EDRs) produced by the Joint Polar Satellite System (JPSS), a National Oceanic and Atmosphere Administration (NOAA) Program, as to their suitability for Earth system science. During the summer of 2014, NASA transitioned to the production of standard Earth Observing System (EOS)-like science products for all instruments aboard Suomi NPP. The five Science Investigator-led Processing Systems (SIPS): Land, Ocean, Atmosphere, Ozone, and Sounder were established to produce the NASA SNPP standard Level 1, Level 2, and global Level 3 products developed by the SNPP Science Teams and to provide the products to NASA's Distributed Active Archive Centers (DAACs) for archive and distribution to the user community. The processing, archiving and distribution of data from NASA's Clouds and the Earth's Radiant Energy System (CERES) and Ozone Mapper/Profiler Suite (OMPS) Limb instruments will continue. With the implementation of the JPSS Block 2 architecture and the launch of JPSS-1, the SDS will receive SNPP data in near real-time via the JPSS Stored Mission Data Hub (JSH), as well as JPSS-1 and future JPSS-2 data. The SNPP SIPS will ingest EOS compatible Level 0 data from the EOS Data Operations System (EDOS) element for their data processing, enabling the continuous EOS-SNPP-JPSS Satellite Data Record.

  14. High-Bandwidth Tactical-Network Data Analysis in a High-Performance-Computing (HPC) Environment: Voice Call Analysis

    DTIC Science & Technology

    2015-09-01

    Gateway 2 4. Voice Packet Flow: SIP , Session Description Protocol (SDP), and RTP 3 5. Voice Data Analysis 5 6. Call Analysis 6 7. Call Metrics 6...analysis processing is designed for a general VoIP system architecture based on Session Initiation Protocol ( SIP ) for negotiating call sessions and...employs Skinny Client Control Protocol for network communication between the phone and the local CallManager (e.g., for each dialed digit), SIP

  15. Sipping at the Straw: Planning for Sustainable Water Supplies for U.S. Army Installations

    DTIC Science & Technology

    2011-05-01

    Thermoelectric power • Geothermal • Biofuels • Solar-hot water • Hydropower • Carbon Capture • “ Fracking ” Regional Water Balance?  Supply  Rivers...Sipping at the Straw: Planning for Sustainable Water Supplies for U.S. Army Installations Marc Kodack Senior Fellow, Army Environmental Policy...00-00-2011 4. TITLE AND SUBTITLE Sipping at the Straw: Planning for Sustainable Water Supplies for U.S. Army Installations 5a. CONTRACT NUMBER 5b

  16. Targeting Unknowns Just Underfoot: Microbial Ecology and Community Genomics of C Cycling in Soil Informed and Enabled with DNA-SIP

    NASA Astrophysics Data System (ADS)

    Pepe-Ranney, C. P.; Campbell, A.; Buckley, D. H.

    2015-12-01

    Microorganisms drive biogeochemical cycles and because soil is a large global carbon (C) reservoir (soil contains more C than plants and the atmosphere combined), soil microorganisms are important players in the global C-cycle. Frustratingly, however, many soil microorganisms resist cultivation and soil communities are astoundingly complex. This makes soil microbiology difficult to study and without a solid understanding of soil microbial ecology, models of soil C feedbacks to climate change are under-informed. Stable isotope probing (SIP) is a useful approach for establishing identity-function connections in microbial communities but has been challenging to employ in soil due to the inadequate resolution of microbial community fingerprinting techniques. High throughput DNA sequencing improves SIP resolving power transforming it into a powerful tool for studying the soil C cycle. We conducted a DNA-SIP experiment to track flow of xylose-C, a labile component of plant biomass, and cellulose-C, the most abundant global biopolymer, through a soil microbial community. We could track 13C into microbial DNA even when added 13C amounted to less than 5% of native C and found Spartobacteria, Chloroflexi, and Planctomycetes taxa were among those that assimilated 13C cellulose. These lineages are cosmopolitan in soil but little is known of their ecophysiology. By profiling SSU rRNA genes across entire DNA-SIP density gradients, we assessed relative DNA atom % 13C per taxon in 13C treatments and found cellulose degraders exhibited signal consistent with a specialist lifestyle with respect to C preference. Further, DNA-SIP enriches DNA of targeted microorganisms (Verrucomicrobia cellulose degraders were enriched by nearly two orders of magnitude) and this enriched DNA can serve as template for community genomics. We produced draft genomes from soil cellulose degraders including microorganisms belonging to Verrucomicrobia, Chloroflexi, and Planctomycetes from SIP enriched DNA. This study demonstrates how DNA-SIP can be used to study microbial ecology and target guilds of microorganisms for community genomics. Improving our fundamental understanding of ecophysiology relevant to terrestrial C cycling is essential for tuning global C models.

  17. Geoelectrical Monitoring of Ammonium Sorption Processes in a Biochar Filtration System

    NASA Astrophysics Data System (ADS)

    Wang, S. L.; Osei, C.; Rabinovich, A.; Ntarlagiannis, D.; Rouff, A.

    2017-12-01

    With the rise of modern agriculture, nutrient pollution has become an increasingly important environmental concern. A common problem is excess nitrogen which agricultural livestock farms often generate in the form of ammonium (NH4+). This highly soluble ion is easily transported through runoff and leaching, leading to water supply contamination and soil fertility decline. Biochar is the carbon-rich product of thermal decomposition of biomass in an oxygen-free environment. It is primarily used as a soil enhancer with other applications currently under research. Biochar's unique characteristics such as high surface area, high sorption capacity and long term biological and chemical stability make it a prime candidate for environmental applications such as contaminant regulation and waste effluent treatment. The spectral induced polarization (SIP) method is an established geoelectrical method that has been increasingly used in environmental investigations. SIP is unique among geophysical methods because it is sensitive not only to the bulk properties of the medium under investigation but also to the interfacial properties (e.g., mineral-fluid). The unique properties that make biochar attractive for environmental use are associated with surface properties (e.g., surface area, surface charge, presence of functional groups) that are expected to have a profound effect on SIP signals. This study presents early results on the use of the SIP method to monitor ammonium recycling of swine wastewater in a biochar filtration system. SIP measurements were taken continuously as biochar-packed columns were first injected with an ammonium wastewater solution (sorption phase) and then an ammonium-free solution (desorption phase). Geochemical monitoring showed that outflow ammonium concentration decreased during the sorption phase and increased during the desorption phase. The collected SIP data appear to be in agreement with the geochemical monitoring, providing a temporally continuous record of changes on the waste fluid and biochar surface. The results suggest that biochar successfully sorbs and releases ammonium and that the SIP method is sensitive these sorption processes. Further research is required for the quantitative interpretation of the SIP signals, including the signal source mechanism.

  18. EPA Approved Regulations in the California SIP

    EPA Pesticide Factsheets

    EPA approved California statutes and regulations incorporated by reference in the applicable State Implementation Plan (SIP), as well as approved test procedures, methods and specifications that are cited in certain regulations listed.

  19. Conformity Adequacy Review: Region 5

    EPA Pesticide Factsheets

    Resources are for air quality and transportation government and community leaders. Information on the conformity SIP adequacy/inadequacy of state implementation plans (SIPs) in EPA Region 5 (IL, IN, MI, OH, WI) is provided here.

  20. Different relations between schedule-induced polydipsia and impulsive behaviour in the Spontaneously Hypertensive Rat and in high impulsive Wistar rats: questioning the role of impulsivity in adjunctive behaviour.

    PubMed

    Ibias, Javier; Pellón, Ricardo

    2014-09-01

    Rats belonging to three different strains (15 Wistar, 8 Spontaneously Hypertensive - SHR- and 8 Wistar Kyoto - WKY-) were used to evaluate the possible relationship between different levels of impulsivity and development of schedule-induced polydipsia (SIP). We first measured the rats' levels of impulsivity by means of delay-discounting and indifference-point procedures. Secondly, development of SIP was studied under a series of fixed time 15, 30, 60 and 120s food schedules, which were counterbalanced by means of a Latin-square design. Finally, we re-assessed the rats' levels of impulsivity by replicating the delay-discounting test. The findings showed that, starting from equivalent levels of impulsivity, development of SIP differed among the groups of rats. In comparison with the rest of the animals, the SHRs were observed to attain elevated drinking rates under SIP. On the other hand, the Wistar rats which had initial high impulsivity levels similar to those of the SHRs, displayed the lowest rates of induced drinking. Moreover, low levels of impulsivity in Wistar rats prior to SIP acquisition were reflected into high drinking rates. Relation of SIP and impulsivity is questioned by present results, which gives ground to the understanding of the behavioural mechanisms involved in adjunctive behaviour and its usefulness as an animal model of excessive behaviour. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Development and implementation of the Caribbean Laboratory Quality Management Systems Stepwise Improvement Process (LQMS-SIP) Towards Accreditation

    PubMed Central

    Alemnji, George; Edghill, Lisa; Wallace-Sankarsingh, Sacha; Albalak, Rachel; Cognat, Sebastien; Nkengasong, John; Gabastou, Jean-Marc

    2017-01-01

    Background Implementing quality management systems and accrediting laboratories in the Caribbean has been a challenge. Objectives We report the development of a stepwise process for quality systems improvement in the Caribbean Region. Methods The Caribbean Laboratory Stakeholders met under a joint Pan American Health Organization/US Centers for Disease Control and Prevention initiative and developed a user-friendly framework called ‘Laboratory Quality Management System – Stepwise Improvement Process (LQMS-SIP) Towards Accreditation’ to support countries in strengthening laboratory services through a stepwise approach toward fulfilling the ISO 15189: 2012 requirements. Results This approach consists of a three-tiered framework. Tier 1 represents the minimum requirements corresponding to the mandatory criteria for obtaining a licence from the Ministry of Health of the participating country. The next two tiers are quality improvement milestones that are achieved through the implementation of specific quality management system requirements. Laboratories that meet the requirements of the three tiers will be encouraged to apply for accreditation. The Caribbean Regional Organisation for Standards and Quality hosts the LQMS-SIP Secretariat and will work with countries, including the Ministry of Health and stakeholders, including laboratory staff, to coordinate and implement LQMS-SIP activities. The Caribbean Public Health Agency will coordinate and advocate for the LQMS-SIP implementation. Conclusion This article presents the Caribbean LQMS-SIP framework and describes how it will be implemented among various countries in the region to achieve quality improvement. PMID:28879149

  2. ICESat Science Investigator led Processing System (I-SIPS)

    NASA Astrophysics Data System (ADS)

    Bhardwaj, S.; Bay, J.; Brenner, A.; Dimarzio, J.; Hancock, D.; Sherman, M.

    2003-12-01

    The ICESat Science Investigator-led Processing System (I-SIPS) generates the GLAS standard data products. It consists of two main parts the Scheduling and Data Management System (SDMS) and the Geoscience Laser Altimeter System (GLAS) Science Algorithm Software. The system has been operational since the successful launch of ICESat. It ingests data from the GLAS instrument, generates GLAS data products, and distributes them to the GLAS Science Computing Facility (SCF), the Instrument Support Facility (ISF) and the National Snow and Ice Data Center (NSIDC) ECS DAAC. The SDMS is the Planning, Scheduling and Data Management System that runs the GLAS Science Algorithm Software (GSAS). GSAS is based on the Algorithm Theoretical Basis Documents provided by the Science Team and is developed independently of SDMS. The SDMS provides the processing environment to plan jobs based on existing data, control job flow, data distribution, and archiving. The SDMS design is based on a mission-independent architecture that imposes few constraints on the science code thereby facilitating I-SIPS integration. I-SIPS currently works in an autonomous manner to ingest GLAS instrument data, distribute this data to the ISF, run the science processing algorithms to produce the GLAS standard products, reprocess data when new versions of science algorithms are released, and distributes the products to the SCF, ISF, and NSIDC. I-SIPS has a proven performance record, delivering the data to the SCF within hours after the initial instrument activation. The I-SIPS design philosophy gives this system a high potential for reuse in other science missions.

  3. [Role of totally implantable systems for long-term vascular access in the treatment of the neoplastic patient].

    PubMed

    Aldrighetti, L; Caterini, R; Ronzoni, M; Jannello, A; Ferla, G

    1995-05-01

    To assess retrospectively the effectiveness, the safety and the impact on the quality of life of the Subcutaneous Infusion Ports (SIPs) for prolonged venous access in the treatment of neoplastic patients. Retrospective analysis of a case series collected-during 30 months (April 1991-September 1993). General Surgery Division and Radiochemotherapy Service. 35 patients (23 male, 12 female), aged between 27-80 years, received 37 SIPs. 2 patients received 2 SIPs. 34 patients were affected by neoplasm; 1 patient had short gut syndrome secondary to massive small bowel resection. The SIP was implanted in all patients in the operating room with the Seldinger technique ("catheter over wire"). The suclavian vein, through an infraclavicular approach, was the only site of venous access. One SIP was implanted in the hepatic artery. All neoplastic patients received chemotherapy. The patient with short gut syndrome had parenteral nutrition. An external infusion device (CADD-1, CADD-plus, Pharmacia) was used in 13 patients for the continuous infusion of either 5-Fluoro-Uracil (1000 mg/m2/die for 5 days, every 28 days) or 5-Fluoro-Deoxy-Uridine (0.15-0.30 mg/kg/die for 14 days, every 28 days). SIP management required the port "flush" with normal saline solution with heparin (100 U/ml) at least every 40 days, using Huber needle. All patients were treated as outpatients. All intraoperative and long-term complications, recorded in the charts of the patients, were reviewed. The rate of intraoperative complications was assessed over 37 procedures. Long-term complications were assessed over 28 patients (7 patients were excluded for lack of follow up data). Incidence of complications was analyzed over patient days, considering the cumulative permanence time of the SIP in a single patient. We recorded 4 intraoperative complications (10.8%). None of them required to stop the procedure and to delay the implant of the SIP. During the follow-up period (range 1-18 months) we had 1 major complication (pleural effusion secondary to TPN extravasation), that is 3.5% of the patients (1/8255 patient days), and 3 minor complications (10.7% of the patients; 1/2751.6 patient days). Patient tolerance was good in all cases. SIP is a safe and effective device for prolonged venous access. We stress the need of a wider use of this type of device for the management of neoplastic patients.

  4. Multimethod Prediction of Physical Parent-Child Aggression Risk in Expectant Mothers and Fathers with Social Information Processing Theory

    PubMed Central

    Rodriguez, Christina M.; Smith, Tamika L.; Silvia, Paul J.

    2015-01-01

    The Social Information Processing (SIP) model postulates that parents undergo a series of stages in implementing physical discipline that can escalate into physical child abuse. The current study utilized a multimethod approach to investigate whether SIP factors can predict risk of parent-child aggression (PCA) in a diverse sample of expectant mothers and fathers. SIP factors of PCA attitudes, negative child attributions, reactivity, and empathy were considered as potential predictors of PCA risk; additionally, analyses considered whether personal history of PCA predicted participants’ own PCA risk through its influence on their attitudes and attributions. Findings indicate that, for both mothers and fathers, history influenced attitudes but not attributions in predicting PCA risk, and attitudes and attributions predicted PCA risk; empathy and reactivity predicted negative child attributions for expectant mothers, but only reactivity significantly predicted attributions for expectant fathers. Path models for expectant mothers and fathers were remarkably similar. Overall, the findings provide support for major aspects of the SIP model. Continued work is needed in studying the progression of these factors across time for both mothers and fathers as well as the inclusion of other relevant ecological factors to the SIP model. PMID:26631420

  5. A Sperm Spawn-Inducing Pheromone in the Silver Lip Pearl Oyster (Pinctada maxima).

    PubMed

    Taylor, A; Mills, D; Wang, T; Ntalamagka, N; Cummins, S F; Elizur, A

    2018-04-28

    Pheromones are considered to play an important role in broadcast spawning in aquatic animals, facilitating synchronous release of gametes. In oysters, the sperm has been implicated as a carrier for the spawn-inducing pheromone (SIP). In hatchery conditions, male pearl oysters (Pinctata maxima) can be stimulated to spawn through a variety of approaches (e.g. rapid temperature change), while females can only be induced to spawn through exposure to conspecific sperm, thus limiting development of targeted pairing, required for genetic research and management. The capacity for commercial production and improvement of genetic lines of pearl oysters could be greatly improved with access to a SIP. In this study, we prepared and sequenced crude and semi-purified P. maxima sperm extracts that were used in bioassays to localise the female SIP. We report that the P. maxima SIP is proteinaceous and extrinsically associated with the sperm membrane. Bioactivity from pooled RP-HPLC fractions, but not individual fractions, suggests that the SIP is multi-component. We conclude that crude sperm preparations, as described in this study, can be used as a sperm-free inducer of female P. maxima spawning, which enables for a more efficient approach to genetic breeding.

  6. Social-Emotional Correlates of Early Stage Social Information Processing Skills in Children With and Without Autism Spectrum Disorder.

    PubMed

    Russo-Ponsaran, Nicole M; McKown, Clark; Johnson, Jason K; Allen, Adelaide W; Evans-Smith, Bernadette; Fogg, Louis

    2015-10-01

    Difficulty processing social information is a defining feature of autism spectrum disorder (ASD). Yet the failure of children with ASD to process social information effectively is poorly understood. Using Crick and Dodge's model of social information processing (SIP), this study examined the relationship between social-emotional (SE) skills of pragmatic language, theory of mind, and emotion recognition on the one hand, and early stage SIP skills of problem identification and goal generation on the other. The study included a sample of school-aged children with and without ASD. SIP was assessed using hypothetical social situations in the context of a semistructured scenario-based interview. Pragmatic language, theory of mind, and emotion recognition were measured using direct assessments. Social thinking differences between children with and without ASD are largely differences of quantity (overall lower performance in ASD), not discrepancies in cognitive processing patterns. These data support theoretical models of the relationship between SE skills and SIP. Findings have implications for understanding the mechanisms giving rise to SIP deficits in ASD and may ultimately inform treatment development for children with ASD. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

  7. Elementary and middle school science improvement project

    NASA Technical Reports Server (NTRS)

    Mcguire, Saundra Yancy

    1987-01-01

    The Alabama A & M University Elementary and Middle School Science Improvement Project (Project SIP) was instituted in response to a need to improve the ability of North Alabama teachers to teach science effectively using the experimental or hands-on approach. The major component of the project was a two-week workshop. Follow-up visits were made to the classrooms of many of the participating teachers to obtain information on how the program was being implemented in the classroom. The administrative aspects of the program, the delivery of the services to participating teachers, and the project outcomes are addressed.

  8. 78 FR 53113 - Approval and Promulgation of Implementation Plans; California; San Joaquin Valley; Contingency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ...EPA is proposing to approve a state implementation plan (SIP) revision submitted by the State of California to address Clean Air Act nonattainment area contingency measure requirements for the 1997 annual and 24-hour fine particulate matter (PM2.5) national ambient air quality standards in the San Joaquin Valley. Final approval of this SIP revision would terminate the sanctions clocks and a federal implementation plan clock that were triggered by EPA's partial disapproval of a related SIP submission on November 9, 2011 (76 FR 69896).

  9. Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium

    PubMed Central

    Jneid, Bakhos; Moreau, Karine; Plaisance, Marc; Rouaix, Audrey; Dano, Julie

    2016-01-01

    Background Salmonella enterica species are enteric pathogens that cause severe diseases ranging from self-limiting gastroenteritis to enteric fever and sepsis in humans. These infectious diseases are still the major cause of morbidity and mortality in low-income countries, especially in children younger than 5 years and immunocompromised adults. Vaccines targeting typhoidal diseases are already marketed, but none protect against non-typhoidal Salmonella. The existence of multiple non-typhoidal Salmonella serotypes as well as emerging antibiotic resistance highlight the need for development of a broad-spectrum protective vaccine. All Salmonella spp. utilize two type III Secretion Systems (T3SS 1 and 2) to initiate infection, allow replication in phagocytic cells and induce systemic disease. T3SS-1, which is essential to invade epithelial cells and cross the barrier, forms an extracellular needle and syringe necessary to inject effector proteins into the host cell. PrgI and SipD form, respectively, the T3SS-1 needle and the tip complex at the top of the needle. Because they are common and highly conserved in all virulent Salmonella spp., they might be ideal candidate antigens for a subunit-based, broad-spectrum vaccine. Principal Findings We investigated the immunogenicity and protective efficacy of PrgI and SipD administered by subcutaneous, intranasal and oral routes, alone or combined, in a mouse model of Salmonella intestinal challenge. Robust IgG (in all immunization routes) and IgA (in intranasal and oral immunization routes) antibody responses were induced against both proteins, particularly SipD. Mice orally immunized with SipD alone or SipD combined with PrgI were protected against lethal intestinal challenge with Salmonella Typhimurium (100 Lethal Dose 50%) depending on antigen, route and adjuvant. Conclusions and Significance Salmonella T3SS SipD is a promising antigen for the development of a protective Salmonella vaccine, and could be developed for vaccination in tropical endemic areas to control infant mortality. PMID:27992422

  10. Technical Data and Reports on Nitrogen Dioxide Measurements and SIP Status

    EPA Pesticide Factsheets

    EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

  11. Technical Data and Reports on Carbon Monoxide Measurements and SIP Status

    EPA Pesticide Factsheets

    EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

  12. 77 FR 31358 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Obesity Counseling for Primary Prevention of Cancer, SIP12-053, Panel C, initial review. In accordance... Resident Knowledge and Practice in Physical Activity, Nutrition, and Obesity Counseling for Primary...

  13. 75 FR 2440 - Approval and Promulgation of Implementation Plans; Kentucky: Approval of Revisions to the State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... SIP provisions relating to, among other things, fluoride emission standards); 64 FR 7790 (removing... provisions from Wyoming SIP relating to, among other things, hydrogen sulfide and fluoride ambient standards...

  14. 75 FR 32190 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... Cognitive Impairment on Co-Occurring Chronic Conditions SIP 10-037 and Epidemiologic Follow- Up Study of... received in response to ``Examining the Impact of Cognitive Impairment on Co- Occurring Chronic Conditions...

  15. A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides

    PubMed Central

    Li, Fangping; Luo, Ping; Liu, Huazhong

    2018-01-01

    Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid (Illex argentinus and Ommastrephes bartrami), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as chemotherapeutic ancillary agent or functional food. Based on the current findings on SIP, we have summarized four topics in this review, including: chemopreventive, antineoplastic, chemosensitive, and procoagulant and anticoagulant activities, which are correlative closely with the actions of anticancer agents on cancer patients, such as anticancer, toxicity and thrombogenesis, with the latter two actions being common causes of death in cancer cases exposed to chemotherapeutic agents. PMID:29597272

  16. Advanced Strain-Isolation-Pad Material with Bonded Fibrous Construction

    NASA Technical Reports Server (NTRS)

    Seibold, R. W.; Saito, C. A.; Buller, B. W.

    1982-01-01

    The feasibility of utilizing air lay and liquid lay felt deposition techniques to fabricate strain isolation pad (SIP) materials for the Space Shuttle Orbiter was demonstrated. These materials were developed as candidate replacements for the present needled felt SIP used between the ceramic tiles and the aluminum skin on the undersurface of the Orbiter. The SIP materials that were developed consisted of high temperature aramid fibers deposited by controlled fluid (air or liquid) carriers to form low density unbonded felts. The deposited felts were then bonded at the fiber intersections with a small amount of high temperature polyimide resin. This type of bonded felt construction can potentially eliminate two of the problems associated with the present SIP, viz., transmittal of localized stresses into the tiles and load history dependent mechanical response. However, further work is needed to achieve adequate through thickness tensile strength in the bonded felts.

  17. DNA stable-isotope probing (DNA-SIP).

    PubMed

    Dunford, Eric A; Neufeld, Josh D

    2010-08-02

    DNA stable-isotope probing (DNA-SIP) is a powerful technique for identifying active microorganisms that assimilate particular carbon substrates and nutrients into cellular biomass. As such, this cultivation-independent technique has been an important methodology for assigning metabolic function to the diverse communities inhabiting a wide range of terrestrial and aquatic environments. Following the incubation of an environmental sample with stable-isotope labelled compounds, extracted nucleic acid is subjected to density gradient ultracentrifugation and subsequent gradient fractionation to separate nucleic acids of differing densities. Purification of DNA from cesium chloride retrieves labelled and unlabelled DNA for subsequent molecular characterization (e.g. fingerprinting, microarrays, clone libraries, metagenomics). This JoVE video protocol provides visual step-by-step explanations of the protocol for density gradient ultracentrifugation, gradient fractionation and recovery of labelled DNA. The protocol also includes sample SIP data and highlights important tips and cautions that must be considered to ensure a successful DNA-SIP analysis.

  18. Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria*

    PubMed Central

    Wang, Dandan; Liang, Jing; Zhang, Yu; Gui, Bin; Wang, Feng; Yi, Xia; Sun, Luyang; Yao, Zhi; Shang, Yongfeng

    2012-01-01

    Apoptosis-inducing factor (AIF) is a caspase-independent death effector. Normally residing in the mitochondrial intermembrane space, AIF is released and translocated to the nucleus in response to proapoptotic stimuli. Nuclear AIF binds to DNA and induces chromatin condensation and DNA fragmentation, characteristics of apoptosis. Until now, it remained to be clarified how the mitochondrial-nuclear translocation of AIF is regulated. Here we report that steroid receptor coactivator-interacting protein (SIP) interacts directly with AIF in mitochondria and specifically inhibits caspase-independent and AIF-dependent apoptosis. Challenging cells with apoptotic stimuli leads to rapid degradation of SIP, and subsequently AIF is liberated from mitochondria and translocated to the nucleus to induce apoptosis. Together, our data demonstrate that SIP is a novel regulator in caspase-independent and AIF-mediated apoptosis. PMID:22371500

  19. The Optimisation of the Expression of Recombinant Surface Immunogenic Protein of Group B Streptococcus in Escherichia coli by Response Surface Methodology Improves Humoral Immunity.

    PubMed

    Díaz-Dinamarca, Diego A; Jerias, José I; Soto, Daniel A; Soto, Jorge A; Díaz, Natalia V; Leyton, Yessica Y; Villegas, Rodrigo A; Kalergis, Alexis M; Vásquez, Abel E

    2018-03-01

    Group B Streptococcus (GBS) is the leading cause of neonatal meningitis and a common pathogen in livestock and aquaculture industries around the world. Conjugate polysaccharide and protein-based vaccines are under development. The surface immunogenic protein (SIP) is a conserved protein in all GBS serotypes and has been shown to be a good target for vaccine development. The expression of recombinant proteins in Escherichia coli cells has been shown to be useful in the development of vaccines, and the protein purification is a factor affecting their immunogenicity. The response surface methodology (RSM) and Box-Behnken design can optimise the performance in the expression of recombinant proteins. However, the biological effect in mice immunised with an immunogenic protein that is optimised by RSM and purified by low-affinity chromatography is unknown. In this study, we used RSM for the optimisation of the expression of the rSIP, and we evaluated the SIP-specific humoral response and the property to decrease the GBS colonisation in the vaginal tract in female mice. It was observed by NI-NTA chromatography that the RSM increases the yield in the expression of rSIP, generating a better purification process. This improvement in rSIP purification suggests a better induction of IgG anti-SIP immune response and a positive effect in the decreased GBS intravaginal colonisation. The RSM applied to optimise the expression of recombinant proteins with immunogenic capacity is an interesting alternative in the evaluation of vaccines in preclinical phase, which could improve their immune response.

  20. SIP metagenomics identifies uncultivated Methylophilaceae as dimethylsulphide degrading bacteria in soil and lake sediment

    PubMed Central

    Eyice, Özge; Namura, Motonobu; Chen, Yin; Mead, Andrew; Samavedam, Siva; Schäfer, Hendrik

    2015-01-01

    Dimethylsulphide (DMS) has an important role in the global sulphur cycle and atmospheric chemistry. Microorganisms using DMS as sole carbon, sulphur or energy source, contribute to the cycling of DMS in a wide variety of ecosystems. The diversity of microbial populations degrading DMS in terrestrial environments is poorly understood. Based on cultivation studies, a wide range of bacteria isolated from terrestrial ecosystems were shown to be able to degrade DMS, yet it remains unknown whether any of these have important roles in situ. In this study, we identified bacteria using DMS as a carbon and energy source in terrestrial environments, an agricultural soil and a lake sediment, by DNA stable isotope probing (SIP). Microbial communities involved in DMS degradation were analysed by denaturing gradient gel electrophoresis, high-throughput sequencing of SIP gradient fractions and metagenomic sequencing of phi29-amplified community DNA. Labelling patterns of time course SIP experiments identified members of the Methylophilaceae family, not previously implicated in DMS degradation, as dominant DMS-degrading populations in soil and lake sediment. Thiobacillus spp. were also detected in 13C-DNA from SIP incubations. Metagenomic sequencing also suggested involvement of Methylophilaceae in DMS degradation and further indicated shifts in the functional profile of the DMS-assimilating communities in line with methylotrophy and oxidation of inorganic sulphur compounds. Overall, these data suggest that unlike in the marine environment where gammaproteobacterial populations were identified by SIP as DMS degraders, betaproteobacterial Methylophilaceae may have a key role in DMS cycling in terrestrial environments. PMID:25822481

  1. State Implementation Plans (SIP): Submissions that EPA has Found Adequate or Inadequate

    EPA Pesticide Factsheets

    EPA/OTAQ’s State and Local Transportation Resources are for air quality and transportation government and community leaders. Information on state implementation plans (SIPs) that EPA has found either adequate or inadequate is provided here.

  2. 47 CFR 64.2103 - Retention of call attempt records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... was answered, which may take the form of an SS7 signaling cause code or SIP signaling message code... may take the form of an SS7 signaling cause code or SIP signaling message code associated with each...

  3. Technical Data and Reports on Sulfur Dioxide (SO2) Measurements and SIP Status

    EPA Pesticide Factsheets

    EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

  4. 40 CFR 57.705 - Contents of SIP Compliance Schedule required by § 57.201(d) (2) and (3).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... process hardware to be used in achieving compliance with the SIP emission limitation including gas... necessary performance improvements; (4) The date for initiating on-site construction or installation of...

  5. Preliminary results of spectral induced polarization measurements, Wadi Bidah District, Kingdom of Saudi Arabia

    USGS Publications Warehouse

    Smith, Bruce D.; Tippens, C.L.; Flanigan, V.J.; Sadek, Hamdy

    1983-01-01

    Laboratory spectral induced polarization (SIP) measurements on 29 carbonaceous schist samples from the Wadi Bidah district show that most are associated with very long polarization decays or, equivalently, large time constants. In contrast, measurements on two massive sulfide samples indicate shorter polarization decays or smaller time constants. This difference in time constants for the polarization process results in two differences in the phase spectra in the frequency range of from 0.06 to 1Hz. First, phase values of carbonaceous rocks generally decrease as a function of increasing frequency. Second, phase values of massive sulfide-bearing rocks increase as a function of increasing frequency. These results from laboratory measurements agree well with those from other reported SIP measurements on graphites and massive sulfides from the Canadian Shield. Four SIP lines, measured by using a 50-m dipole-dipole array, were surveyed at the Rabathan 4 prospect to test how well the results of laboratory sample measurements can be applied to larger scale field measurements. Along one line, located entirely over carbonaceous schists, the phase values decreased as a function of increasing frequency. Along a second line, located over both massive sulfides and carbonaceous schists as defined by drilling, the phase values measured over carbonaceous schists decreased as a function of increasing frequency, whereas those measured over massive sulfides increased. In addition, parts of two lines were surveyed down the axes of the massive sulfide and carbonaceous units. The phase values along these lines showed similar differences between the carbonaceous schists and massive sulfides. To date, the SIP survey and the SIP laboratory measurements have produced the only geophysical data that indicate an electrical difference between the massive sulfide-bearing rocks and the surrounding carbonaceous rocks in the Wadi Bidah district. However, additional sample and field measurements in areas of known mineralization would fully evaluate the SIP method as applied to various geologic environments and styles of massive sulfide mineralization. Additionally, the efficiency of SIP surveys in delineating areas of sulfide mineralization might be improved by surveying lines down the axes of known electrical conductors. An evaluation of the applied research done on the SIP method to date suggests that this technique offers significant exploration applications to massive sulfide exploration in the Kingdom of Saudi Arabia.

  6. Getting sports injury prevention on to public health agendas - addressing the shortfalls in current information sources.

    PubMed

    Finch, Caroline F

    2012-01-01

    Public health policy is a successful population-level strategy for injury prevention but it is yet to be widely applied to the sports sector. Such policy is generally coordinated by government health departments concerned with the allocation of limited resources to health service delivery and preventive programs for addressing large community health issues. Prioritisation of sports injury prevention (SIP) requires high-quality evidence about the size of the problem and its public health burden; identification of at-risk vulnerable groups; confirmed effective prevention solutions; evidence of intervention cost-effectiveness; and quantification of both financial and policy implications of inaction. This paper argues that the major reason for a lack of sports injury policy by government departments for health or sport to date is a lack of relevant information available for policy makers to make their decisions. Key information gaps evident in Australia are used to highlight this problem. SIP policy does not yet rank highly because, relative to other health/injury issues, there is very little hard evidence to support: claims for its priority ranking, the existence of solutions that can be implemented and which will work, and potential cost-savings to government agencies. Moreover, policy action needs to be integrated across government portfolios, including sport, health and others. Until sports medicine research generates high-quality population-level information of direct relevance and importance to policy makers, especially intervention costing and implementation cost-benefit estimates, and fully engage in policy-informing partnerships, SIP will continue to be left off the public health agenda.

  7. California State Implementation Plan (SIP); Proposed Mobile Source Regulations

    EPA Pesticide Factsheets

    EPA is proposing to approve a submittal by the California to revise its SIP establishing standards and other requirements relating to the control of emissions from certain new and in-use on-road and off-road vehicles and engines.

  8. Delineation of subsurface hydrocarbon contamination at a former hydrogenation plant using spectral induced polarization imaging

    NASA Astrophysics Data System (ADS)

    Flores Orozco, Adrián; Kemna, Andreas; Oberdörster, Christoph; Zschornack, Ludwig; Leven, Carsten; Dietrich, Peter; Weiss, Holger

    2012-08-01

    Broadband spectral induced polarization (SIP) measurements were conducted at a former hydrogenation plant in Zeitz (NE Germany) to investigate the potential of SIP imaging to delineate areas with different BTEX (benzene, toluene, ethylbenzene, and xylene) concentrations. Conductivity images reveal a poor correlation with the distribution of contaminants; whereas phase images exhibit two main anomalies: low phase shift values (< 5 mrad) for locations with high BTEX concentrations, including the occurrence of free-phase product (BTEX concentrations > 1.7 g/l), and higher phase values for lower BTEX concentrations. Moreover, the spectral response of the areas with high BTEX concentration and free-phase products reveals a flattened spectrum in the low frequencies (< 40 Hz), while areas with lower BTEX concentrations exhibit a response characterized by a frequency peak. The SIP response was modelled using a Debye decomposition to compute images of the median relaxation-time. Consistent with laboratory studies, we observed an increase in the relaxation-time associated with an increase in BTEX concentrations. Measurements were also collected in the time domain (TDIP), revealing imaging results consistent with those obtained for frequency domain (SIP) measurements. Results presented here demonstrate the potential of the SIP imaging method to discriminate source and plume of dissolved contaminants at BTEX contaminated sites.

  9. The amphetamine sensitization model of schizophrenia symptoms and its effect on schedule-induced polydipsia in the rat.

    PubMed

    Hawken, Emily R; Beninger, Richard J

    2014-05-01

    Amphetamine enhances dopamine (DA) transmission and induces psychotic states or exacerbates psychosis in at-risk individuals. Amphetamine sensitization of the DA system has been proposed as a rodent model of schizophrenia-like symptoms. In humans, excessive nonphysiologic drinking or primary polydipsia is significantly associated with a diagnosis of schizophrenia. In rodents, nonphysiologic drinking can be induced by intermittent presentation of food in the presence of a drinking spout to a hungry animal; this phenomenon is termed, "schedule-induced polydipsia" (SIP). This study aims to determine the effects of amphetamine sensitization on SIP. We injected rats with amphetamine (1.5 mg/kg) daily for 5 days. Following 4 weeks of withdrawal, animals were food restricted and exposed to the SIP protocol (noncontingent fixed-time 1-min food schedule) for daily 2-h sessions for 24 days. Results showed that previously amphetamine-injected animals drank more in the SIP protocol and drank more than controls when the intermittent food presentation schedule was removed. These findings suggest that hyperdopaminergia associated with schizophrenia may contribute to the development of polydipsia in this population. Whether animals that develop SIP have DA dysfunction or aberrant activity of other circuits that modulate DA activity has yet to be clearly defined.

  10. Multimethod prediction of physical parent-child aggression risk in expectant mothers and fathers with Social Information Processing theory.

    PubMed

    Rodriguez, Christina M; Smith, Tamika L; Silvia, Paul J

    2016-01-01

    The Social Information Processing (SIP) model postulates that parents undergo a series of stages in implementing physical discipline that can escalate into physical child abuse. The current study utilized a multimethod approach to investigate whether SIP factors can predict risk of parent-child aggression (PCA) in a diverse sample of expectant mothers and fathers. SIP factors of PCA attitudes, negative child attributions, reactivity, and empathy were considered as potential predictors of PCA risk; additionally, analyses considered whether personal history of PCA predicted participants' own PCA risk through its influence on their attitudes and attributions. Findings indicate that, for both mothers and fathers, history influenced attitudes but not attributions in predicting PCA risk, and attitudes and attributions predicted PCA risk; empathy and reactivity predicted negative child attributions for expectant mothers, but only reactivity significantly predicted attributions for expectant fathers. Path models for expectant mothers and fathers were remarkably similar. Overall, the findings provide support for major aspects of the SIP model. Continued work is needed in studying the progression of these factors across time for both mothers and fathers as well as the inclusion of other relevant ecological factors to the SIP model. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Relationships: empirical contribution. Understanding personality pathology in adolescents: the five factor model of personality and social information processing.

    PubMed

    Hessels, Christel; van den Hanenberg, Danique; de Castro, Bram Orobio; van Aken, Marcel A G

    2014-02-01

    This study seeks to integrate two research traditions that lie at the base of the understanding of personality pathology in adolescents. The first research tradition refers to normal personality according to the Five Factor Model (FFM). The second tradition specifies the key feature of personality disorder as the capacity to mentalize, which can be reflected in Social Information Processing (SIP). In a clinical sample of 96 adolescents, the authors investigated response generation, coping strategy, and memories of past frustrating experiences as part of SIP, as mediator in the relationship between personality and personality pathology, and a possible moderating role of personality on the relationship between SIP and personality pathology. The hypothesized mediation, by which the effects of personality dimensions on personality pathology was expected to be mediated by SIP variables, was found only for the effect of Neuroticism, most specifically on BPD, which appeared to be mediated by memories the patients had about past frustrating conflict situations with peers. Some moderating effects of personality on the relationship between SIP variables and personality pathology were found, suggesting that high Agreeableness and sometimes low Neuroticism can buffer this relationship. These results suggest that personality dimensions and social cognitions both independently and together play a role in adolescents' personality pathology.

  12. 77 FR 31358 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... announced below concerns Coordinating Center for the Managing Epilepsy Well (MEW) Prevention Research Centers Network, SIP12-056, and Managing Epilepsy Well (MEW) Collaborating Center for Epilepsy Self... Managing Epilepsy Well (MEW) Prevention [[Page 31359

  13. Nonattainment and Ozone Transport Region (OTR) SIP Requirements

    EPA Pesticide Factsheets

    The Clean Air Act (CAA) requires a group of northeast states, which make up the Ozone Transport Region (OTR), to submit a SIP and install a certain level of controls for the pollutants that form ozone, even if they meet ozone standards.

  14. Proposed Approval of Kentucky 2008 Transport SIP Submission

    EPA Pesticide Factsheets

    The Environmental Protection Agency (EPA) is proposing to approve Kentucky’s February 28, 2018, draft State Implementation Plan (SIP) submission pertaining to the “good neighbor” provision of the Clean Air Act (CAA or Act) for the 2008 8-hour ozone Nationa

  15. Spectral Induced Polarization Signatures of Ethanol in Sand-Clay Medium

    EPA Science Inventory

    The spectral Induced Polarization (SIP) method has previously been investigated as a tool for detecting physicochemical changes occurring as result of clay-organic interactions in porous media. We performed SIP measurements with a dynamic signal analyzer (NI-4551) on laboratory ...

  16. Optical to extreme ultraviolet reddening curves for normal AGN dust and for dust associated with high-velocity outflows

    NASA Astrophysics Data System (ADS)

    Singh, Japneet; Gaskell, Martin; Gill, Jake

    2017-01-01

    We use mid-IR (WIRE), optical (SDSS), and ultraviolet (GALEX) photometry of over 80,000 AGNs to derive mean attenuation curves from the optical to the rest frame extreme ultraviolet (EUV) for (i) “normal” AGN dust dominating the optical reddening of AGNs and (ii) “BAL dust” - the dust causing the additional extinction in AGNs observed to have broad absorption lines (BALs). Our method confirms that the attenuation curve of “normal” AGN dust is flat in the ultraviolet, as found by Gaskell et al. (2004). In striking contrast to this, the attenuation curve for BAL dust is well fit by a steeply-rising, SMC-like curve. We confirm the shape of the theoretical Weingartner & Draine (2001) SMC curve out to 700 Angstroms but the drop in attenuation to still shorter wavelengths (400 Angstroms) seems to be less than predicted. We find identical attenuation curves for high-ionization and low-ionization BALQSOs. We suggest that attenuation curves appearing to be steeper than the SMC are due to differences in underlying spectra and partial covering by BAL dust. This work was This work was performed under the auspices of the Science Internship Program (SIP) of the University of California at Santa Cruz performed under the auspices of the Science Internship Program (SIP) of the University of California at Santa Cruz.

  17. Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines.

    PubMed

    Zhang, Lei; Zeng, Zhanzhuang; Hu, Chaohua; Bellis, Susan L; Yang, Wendi; Su, Yintao; Zhang, Xinyan; Wu, Yunkun

    2016-01-01

    Conventional oral vaccines with simple architecture face barriers with regard to stimulating effective immunity. Here we describe oral vaccines with an intelligent phase-transitional shielding layer, poly[(methyl methacrylate)-co-(methyl acrylate)-co-(methacrylic acid)]-poly(D,L-lactide-co-glycolide) (PMMMA-PLGA), which can protect antigens in the gastro-intestinal tract and achieve targeted vaccination in the large intestine. With the surface immunogenic protein (SIP) from group B Streptococcus (GBS) entrapped as the antigen, oral administration with PMMMA-PLGA (PTRBL)/Trx-SIP nanoparticles stimulated robust immunity in tilapia, an animal with a relatively simple immune system. The vaccine succeeded in protecting against Streptococcus agalactiae, a pathogen of worldwide importance that threatens human health and is transmitted in water with infected fish. After oral vaccination with PTRBL/Trx-SIP, tilapia produced enhanced levels of SIP specific antibodies and displayed durability of immune protection. 100% of the vaccinated tilapia were protected from GBS infection, whereas the control groups without vaccines or vaccinated with Trx-SIP only exhibited respective infection rates of 100% or >60% within the initial 5 months after primary vaccination. Experiments in vivo demonstrated that the recombinant antigen Trx-SIP labeled with FITC was localized in colon, spleen and kidney, which are critical sites for mounting an immune response. Our results revealed that, rather than the size of the nanoparticles, it is more likely that the negative charge repulsion produced by ionization of the carboxyl groups in PMMMA shielded the nanoparticles from uptake by small intestinal epithelial cells. This system resolves challenges arising from gastrointestinal damage to antigens, and more importantly, offers a new approach applicable for oral vaccination. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Antibacterial activity and effects of Colla corii asini on Salmonella typhimurium invasion in vitro and in vivo.

    PubMed

    Park, Kwang-Il; Lee, Mi-Ra; Oh, Tae-Woo; Kim, Kwang-Youn; Ma, Jin-Yeul

    2017-12-04

    Salmonella enterica serovar Typhimurium is a foodborne pathogen that triggers inflammatory responses in the intestines of humans and livestock. Colla corii asini is a traditional medicine used to treat gynecologic and chronic diseases in Korea and China. However, the antibacterial activity of Colla corii asini has been unknown. In this study, we investigated the antibacterial activity and effects of Colla corii asini extract on Salmonella typhimurium invasion. To tested for antibacterial effects of Colla corii asini extracts, we confirmed the agar diffusion using Luria solid broth medium. Also, we determined the MIC (minimum inhibitory concentration) and the MBC (minimum bactericidal concentration) value of the Colla corii asini ethanol extract (CEE) by using two-fold serial dilution methods. We evaluated the expression of salmonella invasion proteins including SipA, SipB and SipC by using Western blot and qPCR at the concentration of CEE without inhibition of bacterial growth. In vitro and vivo, we determined the inhibitory effect of invasion of S. typhimurium on CEE by using gentamicin assay and S. typhimurium-infected mice. CEE significantly inhibited the growth of Salmonella typhimurium in an agar diffuse assay and had an MIC of 0.78 mg/ml and an MBC of 1.56 mg/ml. Additionally, CEE reduced Salmonella typhimurium cell invasion via the inhibition of Salmonella typhimurium invasion proteins, such as SipA, SipB and SipC. Furthermore, CEE significantly suppressed invasion in the small intestines (ilea) of mice injected with Salmonella typhimurium. These findings show that Colla corii asini exerts antibacterial activity and suppresses Salmonella typhimurium invasion in vitro and in vivo. Together, these findings demonstrate that Colla corii asini is a potentially useful therapeutic herbal medicine for treating salmonella-mediated diseases.

  19. Flow-through SIP - A novel stable isotope probing approach limiting cross-feeding

    NASA Astrophysics Data System (ADS)

    Mooshammer, Maria; Kitzinger, Katharina; Schintlmeister, Arno; Kjedal, Henrik; Nielsen, Jeppe Lund; Nielsen, Per; Wagner, Michael

    2017-04-01

    Stable isotope probing (SIP) is a widely applied tool to link specific microbial populations to metabolic processes in the environment without the prerequisite of cultivation, which has greatly advanced our understanding of the role of microorganisms in biogeochemical cycling. SIP relies on tracing specific isotopically labeled substrates (e.g., 13C, 15N, 18O) into cellular biomarkers, such as DNA, RNA or phospholipid fatty acids, and is considered to be a robust technique to identify microbial populations that assimilate the labeled substrate. However, cross-feeding can occur when labeled metabolites are released from a primary consumer and then used by other microorganisms. This leads to erroneous identification of organisms that are not directly responsible for the process of interest, but are rather connected to primary consumers via a microbial food web. Here, we introduce a new approach that has the potential to eliminate the effect of cross-feeding in SIP studies and can thus also be used to distinguish primary consumers from other members of microbial food webs. In this approach, a monolayer of microbial cells are placed on a filter membrane, and labeled substrates are supplied by a continuous flow. By means of flow-through, labeled metabolites and degradation products are constantly removed, preventing secondary consumption of the substrate. We present results from a proof-of-concept experiment using nitrifiers from activated sludge as model system, in which we used fluorescence in situ hybridization (FISH) with rRNA-targeted oligonucleotide probes for identification of nitrifiers in combination with nanoscale secondary ion mass spectrometry (NanoSIMS) for visualization of isotope incorporation at the single-cell level. Our results show that flow-through SIP is a promising approach to significantly reduce cross-feeding and secondary substrate consumption in SIP experiments.

  20. The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress.

    PubMed

    Chandrashekarappa, Dakshayini G; McCartney, Rhonda R; O'Donnell, Allyson F; Schmidt, Martin C

    2016-12-01

    Saccharomyces cerevisiae express three isoforms of Snf1 kinase that differ by which β subunit is present, Gal83, Sip1 or Sip2. Here we investigate the abundance, activation, localization and signaling specificity of the three Snf1 isoforms. The relative abundance of these isoforms was assessed by quantitative immunoblotting using two different protein extraction methods and by fluorescence microscopy. The Gal83 containing isoform is the most abundant in all assays while the abundance of the Sip1 and Sip2 isoforms is typically underestimated especially in glass-bead extractions. Earlier studies to assess Snf1 isoform function utilized gene deletions as a means to inactivate specific isoforms. Here we use point mutations in Gal83 and Sip2 and a 17 amino acid C-terminal truncation of Sip1 to inactivate specific isoforms without affecting their abundance or association with the other subunits. The effect of low glucose and alkaline stresses was examined for two Snf1 phosphorylation substrates, the Mig1 and Mig2 proteins. Any of the three isoforms was capable of phosphorylating Mig1 in response to glucose stress. In contrast, the Gal83 isoform of Snf1 was both necessary and sufficient for the phosphorylation of the Mig2 protein in response to alkaline stress. Alkaline stress led to the activation of all three isoforms yet only the Gal83 isoform translocates to the nucleus and phosphorylates Mig2. Deletion of the SAK1 gene blocked nuclear translocation of Gal83 and signaling to Mig2. These data strongly support the idea that Snf1 signaling specificity is mediated by localization of the different Snf1 isoforms. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress

    PubMed Central

    Chandrashekarappa, Dakshayini G.; McCartney, Rhonda R.; O’Donnell, Allyson F.; Schmidt, Martin C.

    2016-01-01

    Saccharomyces cerevisiae express three isoforms of Snf1 kinase that differ by which β subunit is present, Gal83, Sip1 or Sip2. Here we investigate the abundance, activation, localization and signaling specificity of the three Snf1 isoforms. The relative abundance of these isoforms was assessed by quantitative immunoblotting using two different protein extraction methods and by fluorescence microscopy. The Gal83 containing isoform is the most abundant in all assays while the abundance of the Sip1 and Sip2 isoforms is typically underestimated especially in glass-bead extractions. Earlier studies to assess Snf1 isoform function utilized gene deletions as a means to inactivate specific isoforms. Here we use point mutations in Gal83 and Sip2 and a 17 amino acid C-terminal truncation of Sip1 to inactivate specific isoforms without affecting their abundance or association with the other subunits. The effect of low glucose and alkaline stresses was examined for two Snf1 phosphorylation substrates, the Mig1 and Mig2 proteins. Any of the three isoforms was capable of phosphorylating Mig1 in response to glucose stress. In contrast, the Gal83 isoform of Snf 1 was both necessary and sufficient for the phosphorylation of the Mig2 protein in response to alkaline stress. Alkaline stress led to the activation of all three isoforms yet only the Gal83 isoform translocates to the nucleus and phosphorylates Mig2. Deletion of the SAK1 gene blocked nuclear translocation of Gal83 and signaling to Mig2. These data strongly support the idea that Snf1 signaling specificity is mediated by localization of the different Snf1 isoforms. PMID:27592031

  2. A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

    PubMed Central

    Andritschke, Daniel; Dilling, Sabrina; Emmenlauer, Mario; Welz, Tobias; Schmich, Fabian; Misselwitz, Benjamin; Rämö, Pauli; Rottner, Klemens; Kerkhoff, Eugen; Wada, Teiji; Penninger, Josef M.; Beerenwinkel, Niko; Horvath, Peter; Dehio, Christoph; Hardt, Wolf-Dietrich

    2016-01-01

    Salmonella Typhimurium (S. Tm) is a leading cause of diarrhea. The disease is triggered by pathogen invasion into the gut epithelium. Invasion is attributed to the SPI-1 type 3 secretion system (T1). T1 injects effector proteins into epithelial cells and thereby elicits rearrangements of the host cellular actin cytoskeleton and pathogen invasion. The T1 effector proteins SopE, SopB, SopE2 and SipA are contributing to this. However, the host cell factors contributing to invasion are still not completely understood. To address this question comprehensively, we used Hela tissue culture cells, a genome-wide siRNA library, a modified gentamicin protection assay and S. TmSipA, a sopBsopE2sopE mutant which strongly relies on the T1 effector protein SipA to invade host cells. We found that S. TmSipA invasion does not elicit membrane ruffles, nor promote the entry of non-invasive bacteria "in trans". However, SipA-mediated infection involved the SPIRE family of actin nucleators, besides well-established host cell factors (WRC, ARP2/3, RhoGTPases, COPI). Stage-specific follow-up assays and knockout fibroblasts indicated that SPIRE1 and SPIRE2 are involved in different steps of the S. Tm infection process. Whereas SPIRE1 interferes with bacterial binding, SPIRE2 influences intracellular replication of S. Tm. Hence, these two proteins might fulfill non-redundant functions in the pathogen-host interaction. The lack of co-localization hints to a short, direct interaction between S. Tm and SPIRE proteins or to an indirect effect. PMID:27627128

  3. Developing a model of short-term integrated palliative and supportive care for frail older people in community settings: perspectives of older people, carers and other key stakeholders.

    PubMed

    Bone, Anna E; Morgan, Myfanwy; Maddocks, Matthew; Sleeman, Katherine E; Wright, Juliet; Taherzadeh, Shamim; Ellis-Smith, Clare; Higginson, Irene J; Evans, Catherine J

    2016-11-01

    understanding how best to provide palliative care for frail older people with non-malignant conditions is an international priority. We aimed to develop a community-based episodic model of short-term integrated palliative and supportive care (SIPS) based on the views of service users and other key stakeholders in the United Kingdom. transparent expert consultations with health professionals, voluntary sector and carer representatives including a consensus survey; and focus groups with older people and carers were used to generate recommendations for the SIPS model. Discussions focused on three key components of the model: potential benefit of SIPS, timing of delivery and processes of integrated working between specialist palliative care and generalist practitioners. Content and descriptive analysis was employed and findings were integrated across the data sources. we conducted two expert consultations (n = 63), a consensus survey (n = 42) and three focus groups (n = 17). Potential benefits of SIPS included holistic assessment, opportunity for end of life discussion, symptom management and carer reassurance. Older people and carers advocated early access to SIPS, while other stakeholders proposed delivery based on complex symptom burden. A priority for integrated working was the assignment of a key worker to co-ordinate care, but the assignment criteria remain uncertain. key stakeholders agree that a model of SIPS for frail older people with non-malignant conditions has potential benefits within community settings, but differ in opinion on the optimal timing and indications for this service. Our findings highlight the importance of consulting all key stakeholders in model development prior to feasibility evaluation. © The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society.

  4. Viirs Land Science Investigator-Led Processing System

    NASA Astrophysics Data System (ADS)

    Devadiga, S.; Mauoka, E.; Roman, M. O.; Wolfe, R. E.; Kalb, V.; Davidson, C. C.; Ye, G.

    2015-12-01

    The objective of the NASA's Suomi National Polar Orbiting Partnership (S-NPP) Land Science Investigator-led Processing System (Land SIPS), housed at the NASA Goddard Space Flight Center (GSFC), is to produce high quality land products from the Visible Infrared Imaging Radiometer Suite (VIIRS) to extend the Earth System Data Records (ESDRs) developed from NASA's heritage Earth Observing System (EOS) Moderate Resolution Imaging Spectroradiometer (MODIS) onboard the EOS Terra and Aqua satellites. In this paper we will present the functional description and capabilities of the S-NPP Land SIPS, including system development phases and production schedules, timeline for processing, and delivery of land science products based on coordination with the S-NPP Land science team members. The Land SIPS processing stream is expected to be operational by December 2016, generating land products either using the NASA science team delivered algorithms, or the "best-of" science algorithms currently in operation at NASA's Land Product Evaluation and Algorithm Testing Element (PEATE). In addition to generating the standard land science products through processing of the NASA's VIIRS Level 0 data record, the Land SIPS processing system is also used to produce a suite of near-real time products for NASA's application community. Land SIPS will also deliver the standard products, ancillary data sets, software and supporting documentation (ATBDs) to the assigned Distributed Active Archive Centers (DAACs) for archival and distribution. Quality assessment and validation will be an integral part of the Land SIPS processing system; the former being performed at Land Data Operational Product Evaluation (LDOPE) facility, while the latter under the auspices of the CEOS Working Group on Calibration & Validation (WGCV) Land Product Validation (LPV) Subgroup; adopting the best-practices and tools used to assess the quality of heritage EOS-MODIS products generated at the MODIS Adaptive Processing System (MODAPS).

  5. Comparison of H.323 and SIP for IP telephony signaling

    NASA Astrophysics Data System (ADS)

    Dalgic, Ismail; Fang, Hanlin

    1999-11-01

    Two standards currently compete for the dominance of IP telephony signaling: the H.323 protocol suite by ITU-T, and the Session Initiation Protocol (SIP) by IETF. Both of these signaling protocols provide mechanisms for call establishment and teardown, call control and supplementary services, and capability exchange. We investigate and compare these two protocols in terms of Functionality, Quality of Service (QoS), Scalability, Flexibility, Interoperability, and Ease of Implementation. For fairness of comparison, we consider similar scenarios for both protocols. In particular, we focus on scenarios that involve a gatekeeper for H.323, and a Proxy/Redirect server for SIP. The reason is that medium-to-large IP Telephony systems are not manageable without a gatekeeper or proxy server. We consider all three versions of H.323. In terms of functionality and services that can be supported, H.323 version 2 and SIP are very similar. However, supplementary services in H.323 are more rigorously defined, and therefore fewer interoperability issues are expected among its implementations. Furthermore, H.323 has taken more steps to ensure compatibility among its different versions, and to interoperate with PSTN. The two protocols are comparable in their QoS support [similar call setup delays, no support for resource reservation or class of service (CoS) setting], but H.323 version 3 will allow signaling of the requested CoS. SIP's primary advantages are (1) flexibility to add new features, and (2) relative ease of implementation and debugging. Finally, we note that H.323 and SIP are improving themselves by learning from each other, and the differences between them are diminishing with each new version.

  6. Intermolecular electron-transfer mechanisms via quantitative structures and ion-pair equilibria for self-exchange of anionic (dinitrobenzenide) donors.

    PubMed

    Rosokha, Sergiy V; Lü, Jian-Ming; Newton, Marshall D; Kochi, Jay K

    2005-05-25

    Definitive X-ray structures of "separated" versus "contact" ion pairs, together with their spectral (UV-NIR, ESR) characterizations, provide the quantitative basis for evaluating the complex equilibria and intrinsic (self-exchange) electron-transfer rates for the potassium salts of p-dinitrobenzene radical anion (DNB(-)). Three principal types of ion pairs, K(L)(+)DNB(-), are designated as Classes S, M, and C via the specific ligation of K(+) with different macrocyclic polyether ligands (L). For Class S, the self-exchange rate constant for the separated ion pair (SIP) is essentially the same as that of the "free" anion, and we conclude that dinitrobenzenide reactivity is unaffected when the interionic distance in the separated ion pair is r(SIP) > or =6 Angstroms. For Class M, the dynamic equilibrium between the contact ion pair (with r(CIP) = 2.7 Angstroms) and its separated ion pair is quantitatively evaluated, and the rather minor fraction of SIP is nonetheless the principal contributor to the overall electron-transfer kinetics. For Class C, the SIP rate is limited by the slow rate of CIP right arrow over left arrow SIP interconversion, and the self-exchange proceeds via the contact ion pair by default. Theoretically, the electron-transfer rate constant for the separated ion pair is well-accommodated by the Marcus/Sutin two-state formulation when the precursor in Scheme 2 is identified as the "separated" inner-sphere complex (IS(SIP)) of cofacial DNB(-)/DNB dyads. By contrast, the significantly slower rate of self-exchange via the contact ion pair requires an associative mechanism (Scheme 3) in which the electron-transfer rate is strongly governed by cationic mobility of K(L)(+) within the "contact" precursor complex (IS(CIP)) according to the kinetics in Scheme 4.

  7. Student Intern Freed Competes at Intel ISEF, Two Others Awarded at Local Science Fair | Poster

    Cancer.gov

    Class of 2014–2015 Werner H. Kirsten (WHK) student intern Rebecca “Natasha” Freed earned a fourth-place award in biochemistry at the 2015 Intel International Science and Engineering Fair (ISEF), the largest high school science research competition in the world, according to the Society for Science & the Public’s website. Freed described the event as “transformative experience,” where she was able to present her research to “experts, including Nobel laureates, as well as members of the general community and, of course, to [other students].”

  8. Nuclear physics with antiprotons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dover, C.B.

    1984-01-01

    Transparencies of an invited talk presented at the Nashville meeting of the American Physical Society, October 18-20, 1984, are included. Topics include: (1) Salient features of two-body N anti N interactions (N anti N reversible NN, annihilation mechanisms (quark models), and optical model phenomenology); (2) anti N-nucleus interactions - elastic, inelastic, etc. (new cross section data, optical potentials, signatures of spin-isospin dependence of N anti N force, and (anti p, p) reactions); and (3) anti N-nucleus annihilation processes (features of cascade or fluid dynamics calculations, searches for baryonium and other exotics, meson interferometry, and (anti p, NN) reactions. (WHK)

  9. Technical Data and Reports on Particulate Matter (PM) Measurements and SIP Status

    EPA Pesticide Factsheets

    EPA collects data from the states and regions on their air quality, including levels of pollutants such as PM, and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

  10. Guidance for 1-Hour Sulfur Dioxide (SO2) Nonattainment Area State Implementation Plans (SIP) Submissions

    EPA Pesticide Factsheets

    The document is intended to provide guidance and recommendations to state, local and tribal governments for the development of SIPs and tribal implementation plans (TIPs) under the 2010 1-hour primary NAAQS for Sulfur Dioxide (SO2).

  11. 77 FR 41279 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Regional Haze State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Promulgation of Air Quality Implementation Plans; Pennsylvania; Regional Haze State Implementation Plan AGENCY... the Regional Haze State Implementation Plan (SIP) (hereafter RH SIP) revision submitted by the... anthropogenic impairment of visibility in mandatory Class I areas [[Page 41280

  12. Presence Management and Merging Presence Information for NGN Services

    NASA Astrophysics Data System (ADS)

    Schumann, Sebastian; Mikoczy, Eugen; Podhradsky, Pavol; Muruchi, Feliciano; Maruschke, Michael

    This paper describes an approach for interworking scenarios between Session Initiation Protocol (SIP) based and non SIP based frameworks (e.g. web services) in case of the presence management service. The characteristics of the concept of a centralized presence management will be introduced.

  13. Comparison of artificial intelligence classifiers for SIP attack data

    NASA Astrophysics Data System (ADS)

    Safarik, Jakub; Slachta, Jiri

    2016-05-01

    Honeypot application is a source of valuable data about attacks on the network. We run several SIP honeypots in various computer networks, which are separated geographically and logically. Each honeypot runs on public IP address and uses standard SIP PBX ports. All information gathered via honeypot is periodically sent to the centralized server. This server classifies all attack data by neural network algorithm. The paper describes optimizations of a neural network classifier, which lower the classification error. The article contains the comparison of two neural network algorithm used for the classification of validation data. The first is the original implementation of the neural network described in recent work; the second neural network uses further optimizations like input normalization or cross-entropy cost function. We also use other implementations of neural networks and machine learning classification algorithms. The comparison test their capabilities on validation data to find the optimal classifier. The article result shows promise for further development of an accurate SIP attack classification engine.

  14. Ultralow-Noise Atomic-Scale Structures for Quantum Circuitry in Silicon.

    PubMed

    Shamim, Saquib; Weber, Bent; Thompson, Daniel W; Simmons, Michelle Y; Ghosh, Arindam

    2016-09-14

    The atomically precise doping of silicon with phosphorus (Si:P) using scanning tunneling microscopy (STM) promises ultimate miniaturization of field effect transistors. The one-dimensional (1D) Si:P nanowires are of particular interest, retaining exceptional conductivity down to the atomic scale, and are predicted as interconnects for a scalable silicon-based quantum computer. Here, we show that ultrathin Si:P nanowires form one of the most-stable electrical conductors, with the phenomenological Hooge parameter of low-frequency noise being as low as ≈10(-8) at 4.2 K, nearly 3 orders of magnitude lower than even carbon-nanotube-based 1D conductors. A in-built isolation from the surface charge fluctuations due to encapsulation of the wires within the epitaxial Si matrix is the dominant cause for the observed suppression of noise. Apart from quantum information technology, our results confirm the promising prospects for precision-doped Si:P structures in atomic-scale circuitry for the 11 nm technology node and beyond.

  15. The Sickness Impact Profile as a measure of the health status of noncognitively impaired nursing home residents.

    PubMed

    Rothman, M L; Hedrick, S; Inui, T

    1989-03-01

    The Sickness Impact Profile (SIP) is a multidimensional, behaviorally based measure of the health status that has been successfully used in a wide range of applications. The characteristics of this measure have not been assessed with nursing home residents. The purpose of this study was to assess the feasibility, reliability (internal consistency), validity, and comprehensiveness of the SIP as a measure of the health status of a selected group of nursing home residents. One hundred sixty-eight veterans residing in community and VA nursing homes responded to a questionnaire consisting of the SIP, Index of Activities of Daily Living, Barthel Index, Life Satisfaction Index Z, and the Philadelphia Geriatric Center Morale Scale. In general, the respondents correctly interpreted instructions; reliability and validity were supported; and the SIP was found to provide a comprehensive assessment of physical function. Adding a measure of psychologic well-being to a study protocol involving this population may, however, provide additional useful information regarding this construct.

  16. Psychometric Properties of Prodromal Questionnaire-Brief Version among Chinese Help-Seeking Individuals

    PubMed Central

    Xu, LiHua; Zhang, TianHong; Zheng, LiNa; Li, HuiJun; Tang, YingYing; Luo, XingGuang; Sheng, JianHua; Wang, JiJun

    2016-01-01

    Prodromal Questionnaire (PQ) and Structured Interview for Prodromal Syndromes (SIPS) have been used as a two-stage process for identifying subjects at clinical high risk (CHR) of psychosis. The Prodromal Questionnaire-Brief version (PQ-B) contains 21 items derived from the PQ. The present study aimed to examine the psychometric properties of PQ-B in a Chinese help-seeking outpatient sample and to explore which items can better predict CHR diagnosis by SIPS and future transition to psychosis. In our preliminary epidemiological study, 1461 patients from a pool of 2101 individuals (15–45 years of age) completed the two-stage process. In the present study, 239 (20%) people were randomly selected among the sample who met the initial PQ-B screening criteria but had no positive diagnosis on SIPS, as well as 72 individuals with negative results on both PQ-B and SIPS, 89 prodromal and 105 psychotic subjects, yielding a total of 505 participants. The internal consistency coefficient for the PQ-B was good, with a Cronbach’s alpha of 0.897. The concordant validity of PQ-B with SIPS dichotomized diagnosis of prodrome/psychosis versus no psychosis was 0.54. To ensure 80% or a higher sensitivity and a certain specificity, 7 and 24 were respectively set as the cutoff points for the PQ-B total score and distress score for Chinese help-seeking outpatients. A logistic regression model based on six PQ-B items could allow predicting the psychotic diagnosis on SIPS, with an accuracy of 65.8%. Prodromal individuals who scored higher on the 12th item of PQ-B (Do you worry at times that something may be wrong with your mind?) were less likely to convert to psychosis. PQ-B is a useful instrument for screening CHR subjects, but the cutoff score may be higher than that recommended by the author scores for help-seeking individuals in outpatient clinics. Some specific PQ-B items may have significant predictive power on dichotomized SIPS diagnoses and deserve special attention from researchers in future studies. PMID:26859774

  17. Quinone-based stable isotope probing for assessment of 13C substrate-utilizing bacteria

    NASA Astrophysics Data System (ADS)

    Kunihiro, Tadao; Katayama, Arata; Demachi, Toyoko; Veuger, Bart; Boschker, Henricus T. S.; van Oevelen, Dick

    2015-04-01

    In this study, we attempted to establish quinone-stable-isotope probing (SIP) technique to link substrate-utilizing bacterial group to chemotaxonomic group in bacterial community. To identify metabolically active bacterial group in various environments, SIP techniques combined with biomarkers have been widely utilized as an attractive method for environmental study. Quantitative approaches of the SIP technique have unique advantage to assess substrate-incorporation into bacteria. As a most major quantitative approach, SIP technique based on phospholipid-derived fatty acids (PLFA) have been applied to simultaneously assess substrate-incorporation rate into bacteria and microbial community structure. This approach is powerful to estimate the incorporation rate because of the high sensitivity due to the detection by a gas chromatograph-combustion interface-isotope ratio mass spectrometer (GC-c-IRMS). However, its phylogenetic resolution is limited by specificity of a compound-specific marker. We focused on respiratory quinone as a biomarker. Our previous study found a good correlation between concentrations of bacteria-specific PLFAs and quinones over several orders of magnitude in various marine sediments, and the quinone method has a higher resolution (bacterial phylum level) for resolving differences in bacterial community composition more than that of bacterial PLFA. Therefore, respiratory quinones are potentially good biomarkers for quantitative approaches of the SIP technique. The LC-APCI-MS method as molecular-mass based detection method for quinone was developed and provides useful structural information for identifying quinone molecular species in environmental samples. LC-MS/MS on hybrid triple quadrupole/linear ion trap, which enables to simultaneously identify and quantify compounds in a single analysis, can detect high molecular compounds with their isotope ions. Use of LC-MS/MS allows us to develop quinone-SIP based on molecular mass differences due to 13C abundance in the quinone. In this study, we verified carbon stable isotope of quinone compared with bulk carbon stable isotope of bacterial culture. Results indicated a good correlation between carbon stable isotope of quinone compared with bulk carbon stable isotope. However, our measurement conditions for detection of quinone isotope-ions incurred underestimation of 13C abundance in the quinone. The quinone-SIP technique needs further optimization for measurement conditions of LC-MS/MS.

  18. Comparison of the surface ion density of silica gel evaluated via spectral induced polarization versus acid-base titration

    NASA Astrophysics Data System (ADS)

    Hao, Na; Moysey, Stephen M. J.; Powell, Brian A.; Ntarlagiannis, Dimitrios

    2016-12-01

    Surface complexation models are widely used with batch adsorption experiments to characterize and predict surface geochemical processes in porous media. In contrast, the spectral induced polarization (SIP) method has recently been used to non-invasively monitor in situ subsurface chemical reactions in porous media, such as ion adsorption processes on mineral surfaces. Here we compare these tools for investigating surface site density changes during pH-dependent sodium adsorption on a silica gel. Continuous SIP measurements were conducted using a lab scale column packed with silica gel. A constant inflow of 0.05 M NaCl solution was introduced to the column while the influent pH was changed from 7.0 to 10.0 over the course of the experiment. The SIP measurements indicate that the pH change caused a 38.49 ± 0.30 μS cm- 1 increase in the imaginary conductivity of the silica gel. This increase is thought to result from deprotonation of silanol groups on the silica gel surface caused by the rise in pH, followed by sorption of Na+ cations. Fitting the SIP data using the mechanistic model of Leroy et al. (Leroyet al., 2008), which is based on the triple layer model of a mineral surface, we estimated an increase in the silica gel surface site density of 26.9 × 1016 sites m- 2. We independently used a potentiometric acid-base titration data for the silica gel to calibrate the triple layer model using the software FITEQL and observed a total increase in the surface site density for sodium sorption of 11.2 × 1016 sites m- 2, which is approximately 2.4 times smaller than the value estimated using the SIP model. By simulating the SIP response based on the calibrated surface complexation model, we found a moderate association between the measured and estimated imaginary conductivity (R2 = 0.65). These results suggest that the surface complexation model used here does not capture all mechanisms contributing to polarization of the silica gel captured by the SIP data.

  19. Molecular characterization of the Salmonella typhi StpA protein that is related to both Yersinia YopE cytotoxin and YopH tyrosine phosphatase.

    PubMed

    Arricau, N; Hermant, D; Waxin, H; Popoff, M Y

    1997-01-01

    Analysis of the nucleotide sequence of a 4-kb DNA fragment located between the sip and iag loci on Salmonella typhi chromosome revealed three open reading frames, termed sipF, ctpA and stpA. The 82-amino-acid (aa) sipF product showed extensive similarity to the lacP protein from S. typhimurium. The StpA protein (535 aa) exhibited significant similarity to both Yersinia enterocolitica YopE cytotoxin and YopH tyrosine phosphatase. The CtpA polypeptide (130 aa) might be the molecular chaperone of the StpA protein.

  20. 77 FR 74129 - Approval and Promulgation of Implementation Plans; Texas; Public Participation for Air Quality...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ...EPA is proposing to approve revisions to the Texas State Implementation Plan (SIP) that establish the public participation requirements for air quality permits. EPA proposes to find that these revisions to the Texas SIP comply with the Federal Clean Air Act (the Act or CAA) and EPA regulations and are consistent with EPA policies. Texas submitted the public participation provisions in four separate revisions to the SIP on July 22, 1998; October 25, 1999; July 2, 2010; and March 11, 2011. EPA is proposing this action under section 110 and parts C and D of the Clean Air Act (the Act).

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