Twenty-five years of ecological recovery of East Fork Poplar Creek: review of environmental problems and remedial actions.

PubMed

Loar, James M; Stewart, Arthur J; Smith, John G

2011-06-01

In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Department of Energy's Y-12 National Security Complex (Y-12 Complex) in Oak Ridge, Tennessee, USA, allowing discharge of effluents to East Fork Poplar Creek (EFPC). The effluents ranged from large volumes of chlorinated once-through cooling water and cooling tower blow-down to smaller discharges of treated and untreated process wastewaters, which contained a mixture of heavy metals, organics, and nutrients, especially nitrates. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to meet two major objectives: demonstrate that the established effluent limitations were protecting the classified uses of EFPC, and document the ecological effects resulting from implementing a Water Pollution Control Program at the Y-12 Complex. The second objective is the primary focus of the other papers in this special series. This paper provides a history of pollution and the remedial actions that were implemented; describes the geographic setting of the study area; and characterizes the physicochemical attributes of the sampling sites, including changes in stream flow and temperature that occurred during implementation of the BMAP. Most of the actions taken under the Water Pollution Control Program were completed between 1986 and 1998, with as many as four years elapsing between some of the most significant actions. The Water Pollution Control Program included constructing nine new wastewater treatment facilities and implementation of several other pollution-reducing measures, such as a best management practices plan; area-source pollution control management; and various spill-prevention projects. Many of the major actions had readily discernable effects on the chemical and physical conditions of EFPC. As controls on effluents entering the stream were implemented, pollutant concentrations generally declined and, at least initially, the volume of water discharged from the Y-12 Complex declined. This reduction in discharge was of ecological concern and led to implementation of a flow management program for EFPC. Implementing flow management, in turn, led to substantial changes in chemical and physical conditions of the stream: stream discharge nearly doubled and stream temperatures decreased, becoming more similar to those in reference streams. While water quality clearly improved, meeting water quality standards alone does not guarantee protection of a waterbody's biological integrity. Results from studies on the ecological changes stemming from pollution-reduction actions, such as those presented in this series, also are needed to understand how best to restore or protect biological integrity and enhance ecological recovery in stream ecosystems. With a better knowledge of the ecological consequences of their decisions, environmental managers can better evaluate alternative actions and more accurately predict their effects.

Twenty-Five Years of Ecological Recovery of East Fork Poplar Creek: Review of Environmental Problems and Remedial Actions

NASA Astrophysics Data System (ADS)

Loar, James M.; Stewart, Arthur J.; Smith, John G.

2011-06-01

In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Department of Energy's Y-12 National Security Complex (Y-12 Complex) in Oak Ridge, Tennessee, USA, allowing discharge of effluents to East Fork Poplar Creek (EFPC). The effluents ranged from large volumes of chlorinated once-through cooling water and cooling tower blow-down to smaller discharges of treated and untreated process wastewaters, which contained a mixture of heavy metals, organics, and nutrients, especially nitrates. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to meet two major objectives: demonstrate that the established effluent limitations were protecting the classified uses of EFPC, and document the ecological effects resulting from implementing a Water Pollution Control Program at the Y-12 Complex. The second objective is the primary focus of the other papers in this special series. This paper provides a history of pollution and the remedial actions that were implemented; describes the geographic setting of the study area; and characterizes the physicochemical attributes of the sampling sites, including changes in stream flow and temperature that occurred during implementation of the BMAP. Most of the actions taken under the Water Pollution Control Program were completed between 1986 and 1998, with as many as four years elapsing between some of the most significant actions. The Water Pollution Control Program included constructing nine new wastewater treatment facilities and implementation of several other pollution-reducing measures, such as a best management practices plan; area-source pollution control management; and various spill-prevention projects. Many of the major actions had readily discernable effects on the chemical and physical conditions of EFPC. As controls on effluents entering the stream were implemented, pollutant concentrations generally declined and, at least initially, the volume of water discharged from the Y-12 Complex declined. This reduction in discharge was of ecological concern and led to implementation of a flow management program for EFPC. Implementing flow management, in turn, led to substantial changes in chemical and physical conditions of the stream: stream discharge nearly doubled and stream temperatures decreased, becoming more similar to those in reference streams. While water quality clearly improved, meeting water quality standards alone does not guarantee protection of a waterbody's biological integrity. Results from studies on the ecological changes stemming from pollution-reduction actions, such as those presented in this series, also are needed to understand how best to restore or protect biological integrity and enhance ecological recovery in stream ecosystems. With a better knowledge of the ecological consequences of their decisions, environmental managers can better evaluate alternative actions and more accurately predict their effects.

Y-12 National Security Complex Biological Monitoring And Abatement Program 2008 Calendar Year Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, M. J.; Greeley Jr., M. S.; Mathews, T. J.

2009-07-01

The National Pollutant Discharge Elimination System (NPDES) permit issued for the Oak Ridge Y-12 National Security Complex (Y-12 Complex) which became effective May 1, 2006, continued a requirement for a Biological Monitoring and Abatement Program (BMAP). The BMAP was originally developed in 1985 to demonstrate that the effluent limitations established for the Y-12 Complex protected the classified uses of the receiving stream (East Fork Poplar Creek: EFPC), in particular, the growth and propagation of aquatic life (Loar et al. 1989). The objectives of the current BMAP are similar, specifically to assess stream ecological conditions relative to regulatory limits and criteria,more » to assess ecological impacts as well as recovery in response to Y-12 operations, and to investigate the causes of continuing impacts. The BMAP consists of three tasks that reflect complementary approaches to evaluating the effects of the Y-12 Complex discharges on the biotic integrity of EFPC. These tasks include: (1) bioaccumulation monitoring, (2) benthic macroinvertebrate community monitoring, and (3) fish community monitoring. As required by the NPDES permit, the BMAP benthic macroinvertebrate community monitoring task includes studies to annually evaluate the receiving stream's biological integrity in comparison to TN Water Quality Criteria. BMAP monitoring is currently being conducted at five primary EFPC sites, although sites may be excluded or added depending upon the specific objectives of the various tasks. Criteria used in selecting the sites include: (1) location of sampling sites used in other studies, (2) known or suspected sources of downstream impacts, (3) proximity to U.S. Department of Energy (DOE) Oak Ridge Reservation (ORR) boundaries, (4) appropriate habitat distribution, and (5) access. The primary sampling sites include upper EFPC at kilometers (EFKs) 24.4 and 23.4 [upstream and downstream of Lake Reality (LR) respectively]; EFK 18.7 (also EFK 18.2 and 19), located off the ORR and below an area of intensive commercial and light industrial development; EFK 13.8, located upstream from the Oak Ridge Wastewater Treatment Facility (ORWTF); and EFK 6.3 located approximately 1.4 km below the ORR boundary (Fig. 1.1). Actual sampling locations on EFPC may differ slightly by task according to specific requirements of the task. Brushy Fork (BF) at kilometer (BFK) 7.6 and Hinds Creek at kilometer (HCK) 20.6 are the most commonly used reference sites for the Y-12 BMAP. Additional sites off the ORR are also occasionally used for reference, including Beaver Creek, Bull Run, Cox Creek, and Paint Rock Creek (Fig. 1.2). Summaries of the sampling designs for the three primary tasks of the Y-12 Complex BMAP for EFPC are presented in Tables 1.1-1.3. This report covers the 2008 period, although data collected outside this time period are included as appropriate. To address the biological monitoring requirements for Bear Creek and McCoy Branch, CERLCA-funded programs, data are summarized in Appendix A and Appendix B respectively. Data for these two watersheds are provided herein to address Section IX of the NPDES Permit for Y-12, where 'Results of these CERCLA programs can be used to meet the biological monitoring requirements of this permit...'. A summary of the toxicity testing results for Y-12 outfalls into upper EFPC is provided in Appendix C (these results have been previously reported) to provide a more thorough perspective of conditions in the stream. Data summarized in this report are available from the Oak Ridge Environmental Information system (OREIS) in an Arc-GIS usable format (http://www-oreis.bechteljacobs.org/oreis/help/oreishome.html). Per requirements specified in the NPDES permit, data collected following TDEC monitoring protocols (TDEC 2006) is also submitted directly to TDEC in Excel format.« less

Our Hidden Past: Peacetime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Ray

Y-12 separated isotopes to win the war, then during the 1950s separated isotopes to save lives. Y-12's calutrons were used for a peacetime mission in the stable isotope program. Y-12 provided stable isotopes for research in medicine, agriculture, industry and biology.

Our Hidden Past: Peacetime

ScienceCinema

Smith, Ray

2018-06-04

Y-12 separated isotopes to win the war, then during the 1950s separated isotopes to save lives. Y-12's calutrons were used for a peacetime mission in the stable isotope program. Y-12 provided stable isotopes for research in medicine, agriculture, industry and biology.

Groundwater Protection Program Calendar Year 1998 Groundwater Monitoring Report, U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-03-01

This annual monitoring report contains groundwater and surface water monitoring data obtained during calendar year (CY) 1998 by the Lockheed Martin Energy Systems, Inc. Y-12 Plant Groundwater Protection Program (GWPP) at the U.S. Department of Energy (DOE) Oak Ridge Y-12 Plant, Groundwater and surface water monitoring during CY 1998 was performed in three hydrogeologic regimes at the Y-12 Plant: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime), and the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valleymore » (BCV), and the Chestnut Ridge Regime which is located south of the Y-12 Plant.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC

This report contains the groundwater and surface water monitoring data that were obtained during calendar year (CY) 2008 at the U.S. Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12) on the DOE Oak Ridge Reservation (ORR) in Oak Ridge, Tennessee. The CY 2008 monitoring data were obtained from wells, springs, and surface water sampling locations in three hydrogeologic regimes at Y-12 (Figure A.1). The Bear Creek Hydrogeologic Regime (Bear Creek Regime) encompasses a section of Bear Creek Valley (BCV) between the west end of Y-12 and the west end of the Bear Creek Watershed (directions aremore » in reference to the Y-12 grid system). The Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime) encompasses the Y-12 industrial facilities and support structures in BCV. The Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime) encompasses a section of Chestnut Ridge directly south of Y-12. Section 2 of this report provides background information pertinent to groundwater and surface water quality monitoring in each hydrogeologic regime, including the topography and bedrock geology, surface water drainage, groundwater system, and extent of groundwater contamination. The CY 2008 groundwater and surface water monitoring data in this report were obtained from sampling and analysis activities implemented under the Y-12 Groundwater Protection Program (GWPP) managed by Babcock & Wilcox Technical Services Y-12, LLC (B&W Y-12) and from sampling and analysis activities implemented under several monitoring programs managed by Bechtel Jacobs Company LLC (BJC). Cooperative implementation of the monitoring programs directed by the Y-12 GWPP and BJC (i.e., coordinating sample collection and sharing data) ensures that the CY 2008 monitoring results fulfill requirements of all the applicable monitoring drivers with no duplication of sampling and analysis efforts. Section 3 of this report contains a summary of information regarding the groundwater and surface water sampling and analysis activities implemented under the Y-12 GWPP including sampling locations and frequency; quality assurance (QA)/quality control (QC) sampling; sample collection and handling; field measurements and laboratory analytes; data management and data quality objective (DQO) evaluation; and groundwater elevation monitoring. However, this report does not include equivalent QA/QC or DQO evaluation information regarding the groundwater and surface water sampling and analysis activities associated with the monitoring programs implemented by BJC. Such details are deferred to the respective programmatic plans and reports issued by BJC (see Section 3.0).« less

Martin Marietta, Y-12 Plant Laboratory Partnership Program Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koger, J.

1995-02-10

The Y-12 Plant currently embraces three mission areas; stockpile surveillance, maintaining production capability, and storage of special nuclear materials. The Y-12 Plant also contributes to the nations` economic strength by partnering with industry in deploying technology. This partnering has been supported to a great extent through the Technology Transfer Initiative (TTI) directed by DOE/Defense Programs (DP-14). The Oak Ridge Centers for Manufacturing Technology (ORCMT) was established to draw upon the manufacturing and fabrication capabilities at the Y-12 Plant to coordinate and support collaborative efforts, between DP and the domestic industrial sector, toward the development of technologies which offer mutual benefitmore » to both DOE/DP programs and the private sector. Most of the needed technologies for the ``Factory of the Future`` (FOF) are being pursued as core areas at the Y-12 Plant. As a result, 85% of DP-14 projects already support the FOF. The unique capabilities of ORCMT can be applied to a wide range of manufacturing problems to enhance the capabilities of the US industrial base and its economic outcome. The ORCMT has an important role to play in DOE`s Technology Transfer initiative because its capabilities are focused on applied manufacturing and technology deployment which has a more near-term impact on private sector competitiveness. The Y-12 Plant uses the ORCMT to help maintain its own core competencies for the FOF by challenging its engineers and capabilities with technical problems from industry. Areas of strength at the Y-12 Plant that could impact the FOF include modeling of processes and advanced materials; intelligent inspection systems with standardized operator interfaces, analysis software, and part programming language; electronic transfer of designs and features; existing computer-based concurrent engineering; and knowledge-based forming process.« less

Y-12 Site Sustainability Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spencer, Charles G

2012-12-01

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) vision for a commitment to energy effi ciency and sustainability and to achievement of the Guiding Principles. Specifi cally, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan, while promoting overall sustainability and reduction of greenhouse gas emissions. The mission of the Y-12 Energy Management program is to incorporate energy-effi cient technologies site-wide and to position Y-12 tomore » meet NNSA energy requirement needs through 2025 and beyond. The plan addresses greenhouse gases, buildings, fleet management, water use, pollution prevention, waste reduction, sustainable acquisition, electronic stewardship and data centers, site innovation and government-wide support.« less

Y-12 Groundwater Protection Program Groundwater and Surface Water Sampling and Analysis Plan for Calendar Year 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2004-09-30

This plan provides a description of the groundwater and surface water quality monitoring activities planned for calendar year (CY) 2005 at the U.S. Department of Energy (DOE) Y-12 National Security Complex (Y-12) that will be managed by the Y-12 Groundwater Protection Program (GWPP). Groundwater and surface water monitoring performed by the GWPP during CY 2005 will be in accordance with DOE Order 540.1 requirements and the following goals: (1) to maintain surveillance of existing and potential groundwater contamination sources; (2) to provide for the early detection of groundwater contamination and determine the quality of groundwater and surface water where contaminantsmore » are most likely to migrate beyond the Oak Ridge Reservation property line; (3) to identify and characterize long-term trends in groundwater quality at Y-12; and (4) to provide data to support decisions concerning the management and protection of groundwater resources. Groundwater and surface water monitoring during CY 2005 will be performed primarily in three hydrogeologic regimes at Y-12: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime), and the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valley, and the Chestnut Ridge Regime is located south of Y-12 (Figure A.1). Additional surface water monitoring will be performed north of Pine Ridge, along the boundary of the Oak Ridge Reservation (Figure A.1). Modifications to the CY 2005 monitoring program may be necessary during implementation. Changes in programmatic requirements may alter the analytes specified for selected monitoring wells or may add or remove wells from the planned monitoring network. All modifications to the monitoring program will be approved by the Y-12 GWPP manager and documented as addenda to this sampling and analysis plan.« less

Technology needs for environmental restoration remedial action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J.S.

1992-11-01

This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This ismore » not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs.« less

Measurement and Modeling of Ecosystem Risk and Recovery for In Situ Treatment of Contaminated Sediments

DTIC Science & Technology

2013-08-01

Hydrocarbons in Petroleum- Impacted Sediments." Environmental Science & Technology 47(2): 1024-1032. Choi, Y., Y. M. Cho, et al. (2013). "Measurement and...4020 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) Strategic Environmental Research and Development...was prepared under contract to the Department of Defense Strategic Environmental Research and Development Program (SERDP). The publication of this

76 FR 57983 - Notice of the Availability of the Draft Framework for the U.S.-Mexico Environmental Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

...]a de Medio Ambiente y Recursos Naturales (Mexico's Secretariat of Environment and Natural Resources..., El Paso, TX 79902. Fax: (915) 544-6026. Secretaria del Medio Ambiente y Recursos Naturales (SEMARNAT...). ACTION: Notice. SUMMARY: The U.S. Environmental Protection Agency (EPA) and the Secretaria de Medio...

Y-12 Sustainability and Stewardship

ScienceCinema

John Krueger

2017-12-09

The Y-12 National Security Complex recently won a White House award for its leadership among Government installations for pollution prevention. This video tells the story of the many actions taken by this NNSA National Security Enterprise site towards being a responsible environmental citizen while protecting the national interest.

Y-12 Sustainability and Stewardship

DOE Office of Scientific and Technical Information (OSTI.GOV)

John Krueger

2009-10-06

The Y-12 National Security Complex recently won a White House award for its leadership among Government installations for pollution prevention. This video tells the story of the many actions taken by this NNSA National Security Enterprise site towards being a responsible environmental citizen while protecting the national interest.

Y-12 Groundwater Protection Program Groundwater and Surface Water Sampling and Analysis Plan for Calendar Year 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC for the Environmental Compliance Department ES&H Division, Y-12 National Security Complex Oak Ridge, Tennessee

2003-09-30

This plan provides a description of the groundwater and surface water quality monitoring activities planned for calendar year (CY) 2004 at the U.S. Department of Energy (DOE) Y-12 National Security Complex that will be managed by the Y-12 Groundwater Protection Program (GWPP). Groundwater and surface water monitoring performed by the GWPP during CY 2004 will be in accordance with the following requirements of DOE Order 5400.1: (1) to maintain surveillance of existing and potential groundwater contamination sources; (2) to provide for the early detection of groundwater contamination and determine the quality of groundwater and surface water where contaminants are mostmore » likely to migrate beyond the Oak Ridge Reservation property line; (3) to identify and characterize long-term trends in groundwater quality at Y-12; and (4) to provide data to support decisions concerning the management and protection of groundwater resources. Groundwater and surface water monitoring during CY 2004 will be performed primarily in three hydrogeologic regimes at Y-12: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime), and the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valley, and the Chestnut Ridge Regime is located south of Y-12 (Figure A.1). Additional surface water monitoring will be performed north of Pine Ridge, along the boundary of the Oak Ridge Reservation (Figure A.1). Modifications to the CY 2004 monitoring program may be necessary during implementation. Changes in programmatic requirements may alter the analytes specified for selected monitoring wells, or wells could be added or removed from the planned monitoring network. All modifications to the monitoring program will be approved by the Y-12 GWPP manager and documented as addenda to this sampling and analysis plan.« less

Y-12 Groundwater Protection Program Monitoring Optimization Plan for Groundwater Monitoring Wells at the U.S. Department of Energy Y-12 National Security Complex, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

This document is the monitoring optimization plan for groundwater monitoring wells associated with the U.S. Department of Energy (DOE) Y-12 National Security Complex (Y-12) in Oak Ridge, Tennessee. The plan describes the technical approach that is implemented under the Y-12 Groundwater Protection Program (GWPP) to focus available resources on the monitoring wells at Y-12 that provide the most useful hydrologic and groundwater quality monitoring data. The technical approach is based on the GWPP status designation for each well. Under this approach, wells granted “active” status are used by the GWPP for hydrologic monitoring and/or groundwater quality sampling, whereas wells grantedmore » “inactive” status are not used for either purpose. The status designation also defines the frequency at which the GWPP will inspect applicable wells, the scope of these well inspections, and extent of any maintenance actions initiated by the GWPP. Details regarding the ancillary activities associated with implementation of this plan (e.g., well inspection) are deferred to the referenced GWPP plans.« less

Remedial Investigation Work Plan for Upper East Fork Poplar Creek Operable Unit 3 at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-08-01

Upper East Fork Popular Creek Operable Unit 3 (UEFPC OU 3) is a source term OU composed of seven sites, and is located in the western portion of the Y-12 Plant. For the most part, the UEFPC OU 3 sites served unrelated purposes and are geographically removed from one another. The seven sites include the following: Building 81-10, the S-2 Site, Salvage Yard oil storage tanks, the Salvage Yard oil/solvent drum storage area, Tank Site 2063-U, the Salvage Yard drum deheader, and the Salvage Yard scrap metal storage area. All of these sites are contaminated with at least one ormore » more hazardous and/or radioactive chemicals. All sites have had some previous investigation under the Y-12 Plant RCRA Program. The work plan contains summaries of geographical, historical, operational, geological, and hydrological information specific to each OU 3 site. The potential for release of contaminants to receptors through various media is addressed, and a sampling and analysis plan is presented to obtain objectives for the remedial investigation. Proposed sampling activities are contingent upon the screening level risk assessment, which includes shallow soil sampling, soil borings, monitoring well installation, groundwater sampling, and surface water sampling. Data from the site characterization activities will be used to meet the above objectives. A Field Sampling Investigation Plan, Health and Safety Plan, and Waste Management Plan are also included in this work plan.« less

Evaluation of fish kills during November 1986 and July 1987 in upper East Fork Poplar Creek near the Y-12 Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryon, M.G.; Loar, J.M.; Southworth, G.R.

1990-09-01

The Environmental Sciences Division (ESD) investigated two fish kills that occurred on November 21, 1986, and July 9, 1987, in upper East Fork Poplar Creek at the outfall of New Hope Pond (NHP) below the Oak Ridge Y-12 Plant. Investigative procedures included sampling of water at the inlet and outfall of NHP for water quality, examination of operating procedures at the Y-12 Plant and in the biomonitoring program that may have adversely affected the fish populations, review of results of concurrent ambient toxicity tests of the inlet and outfall water of NHP, autopsy investigations of the cause of death ofmore » the stonerollers, and laboratory experimentation to evaluate potential causes. The investigations revealed that the cause of death was bacterial hemorrhagic septicemia caused by Aeromonas hydrophila, which is a stress-mediated disease. The specific stressor responsible for the outbreak of the disease was not identified. Several possible stresses were indicated, including elevated concentrations of mercury and chlorine, excessive electroshocking activity, and elevated levels of the pathogen. Cumulative stress due to the combination of several factors was also suggested. Elevated temperatures and overcrowding may have enhanced the spread of the epizootic but were not the primary causes. The impact on the stoneroller population below NHP was not ecologically significant. 23 refs., 3 figs., 12 tabs.« less

An Environmental Education Program (K-12), Based on Environmental Encounters

ERIC Educational Resources Information Center

Stapp, William B.

1971-01-01

Describes a strategy for development and implementation of a comprehensive environmental education program (K-12) which can be integrated into existing curriculum of a school. Environmental encounters" stressed as meaningful approaches to goal achievement. Philosophy of spaceship earth" is fundamental to the program. (LK)

Environmental impact of converting Conservation Reserve Program land to perennial bioenergy crops in Illinois.

NASA Astrophysics Data System (ADS)

Blanc-Betes, E.; Hudiburg, T. W.; Khanna, M.; DeLucia, E. H.

2017-12-01

Reducing dependence on fossil fuels by the 20% by 2022 mandated by the Energy Independence and Security Act would require 35 billion Ga of ethanol and the loss of 9 to 12 Mha of food producing land to biofuel production, challenging our ability to develop a sustainable bioenergy source while meeting the food demands of a growing population. There are currently 8.5 Mha of land enrolled in the Conservation Reserve Program (CRP), a US government funded program to incentivize the retirement of environmentally sensitive cropland out of conventional crop production. About 63% of CRP land area could potentially be converted to energy crops, contributing to biofuel targets without displacing food. With high yields and low fertilization and irrigation requirements, perennial cellulosic crops (e.g. switchgrass and Miscanthus) not only would reduce land requirements by up to 15% compared to prairies or corn-based biofuel, but also serve other conservation goals such as C sequestration in soils, and water and air quality improvement. Here, we use the DayCent biogeochemical model to assess the potential of CRP land conversion to switchgrass or Miscanthus to provide a sustainable source of biofuel, reduce GHG emissions and increase soil organic carbon (SOC) storage in the area of Illinois, which at present contributes to 10% of the biofuel production in the US. Model simulations indicate that the replacement of traditional corn-soy rotation with CRP reduces GHG emissions by 3.3 Mg CO2-eq ha-1 y-1 and increases SOC storage at a rate of 0.5 Mg C ha-1 y-1. Conversion of CRP land to cellulosic perennials would further reduce GHG emissions by 1.1 Mg CO2-eq ha-1 y-1 for switchgrass and 6.2 Mg CO2-eq ha-1 y-1 for Miscanthus, and increase C sequestration in soils (1.7 Tg C for switchgrass and 7.7 Tg C for Miscanthus in 30 years). Cellulosic energy crops would increase average annual yields by approximately 5.6 Mg ha-1 for switchgrass and 13.6 Mg ha-1 for Miscanthus, potentially producing 78 and 188 million Ga of bioethanol annually, respectively. This represents an increase of 5% and 12% in the Illinois annual biofuel production, displacing up to 4% of current fossil fuel consumption in the state of Illinois without detriment for food production.

Remedial Investigation Report on the Abandoned Nitric Acid Pipeline at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Energy Systems Environmental Restoration Program; Y-12 Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-02-01

Upper East Fork Poplar Creek Operable Unit 2 consists of the Abandoned Nitric Acid pipeline (ANAP). This pipeline was installed in 1951 to transport liquid wastes {approximately}4800 ft from Buildings 9212, 9215, and 9206 to the S-3 Ponds. Materials known to have been discharged through the pipeline include nitric acid, depleted and enriched uranium, various metal nitrates, salts, and lead skimmings. During the mid-1980s, sections of the pipeline were removed during various construction projects. A total of 19 locations were chosen to be investigated along the pipeline for the first phase of this Remedial Investigation. Sampling consisted of drilling downmore » to obtain a soil sample at a depth immediately below the pipeline. Additional samples were obtained deeper in the subsurface depending upon the depth of the pipeline, the depth of the water table, and the point of auger refusal. The 19 samples collected below the pipeline were analyzed by the Oak Ridge Y-12 Plant`s laboratory for metals, nitrate/nitrite, and isotopic uranium. Samples collected from three boreholes were also analyzed for volatile organic compounds because these samples produced a response with organic vapor monitoring equipment. Uranium activities in the soil samples ranged from 0.53 to 13.0 pCi/g for {sup 238}U, from 0.075 to 0.75 pCi/g for {sup 235}U, and from 0.71 to 5.0 pCi/g for {sup 238}U. Maximum total values for lead, chromium, and nickel were 75.1 mg/kg, 56.3 mg/kg, and 53.0 mg/kg, respectively. The maximum nitrate/nitrite value detected was 32.0 mg-N/kg. One sample obtained adjacent to a sewer line contained various organic compounds, at least some of which were tentatively identified as fragrance chemicals commonly associated with soaps and cleaning solutions. The results of the baseline human health risk assessment for the ANAP contaminants of potential concern show no unacceptable risks to human health.« less

Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-05-01

This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with themore » monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.« less

Ecological risks of DOE`s programmatic environmental restoration alternatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-06-01

This report assesses the ecological risks of the Department of Energy`s (DOE) Environmental Restoration Program. The assessment is programmatic in that it is directed at evaluation of the broad programmatic alternatives outlined in the DOE Implementation Plan. It attempts to (1) characterize the ecological resources present on DOE facilities, (2) describe the occurrence and importance of ecologically significant contamination at major DOE facilities, (3) evaluate the adverse ecological impacts of habitat disturbance caused by remedial activities, and (4) determine whether one or another of the programmatic alternatives is clearly ecologically superior to the others. The assessment focuses on six representativemore » facilities: the Idaho National Engineering Laboratory (INEL); the Fernald Environmental Management Project (FEMP); the Oak Ridge Reservation (ORR), including the Oak Ridge National Laboratory (ORNL), Y-12 plant, and K-25 plant; the Rocky Flats Plant; the Hanford Reservation; and the Portsmouth Gaseous Diffusion Plant.« less

History of mercury use and environmental contamination at the Oak Ridge Y-12 Plant.

PubMed

Brooks, Scott C; Southworth, George R

2011-01-01

Between 1950 and 1963 approximately 11 million kilograms of mercury (Hg) were used at the Oak Ridge Y-12 National Security Complex (Y-12 NSC) for lithium isotope separation processes. About 3% of the Hg was lost to the air, soil and rock under facilities, and East Fork Poplar Creek (EFPC) which originates in the plant site. Smaller amounts of Hg were used at other Oak Ridge facilities with similar results. Although the primary Hg discharges from Y-12 NSC stopped in 1963, small amounts of Hg continue to be released into the creek from point sources and diffuse contaminated soil and groundwater sources within Y-12 NSC. Mercury concentration in EFPC has decreased 85% from ∼2000 ng/L in the 1980s. In general, methylmercury concentrations in water and in fish have not declined in response to improvements in water quality and exhibit trends of increasing concentration in some cases. Published by Elsevier Ltd.

Measuring the effectiveness of in-hospital and on-base Prevent Alcohol and Risk-related Trauma in Youth (P.A.R.T.Y.) programs on reducing alcohol related harms in naval trainees: P.A.R.T.Y. Defence study protocol.

PubMed

Watterson, Jason; Gabbe, Belinda; Dietze, Paul; Thompson, Jennifer; Oborn, Michael; Rosenfeld, Jeffrey V

2017-05-02

Reducing alcohol related harms in Australian Defence Force (ADF) trainees has been identified as a priority, but there are few evidence-based prevention programs available for the military setting. The study aims to test whether the P.A.R.T.Y. program delivered in-hospital or on-base, can reduce harmful alcohol consumption among ADF trainees. The study is a 3-arm randomized controlled trial, involving 953 Royal Australian Navy trainees from a single base. Trainees, aged 18 to 30 years, will be randomly assigned to the study arms: i. in-hospital P.A.R.T.Y.; ii. On-base P.A.R.T.Y.; and iii. All groups will receive the routine ADF annual alcohol awareness training. The primary outcome is the proportion of participants reporting an Alcohol Use Disorders Identification Test (AUDIT) score of 8 or above at 12 months' post-intervention. The secondary outcome is the number of alcohol related incidents reported to the Royal Australian Navy (RAN) in the 12 months' post-intervention. This is the first trial of the use of the P.A.R.T.Y. program in the military. If the proposed intervention proves efficacious, it may be a useful program in the early education of RAN trainees. Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12614001332617 , date of registration: 18/12/2014 'retrospectively registered'.

Second report on the Oak Ridge Y-12 Plant Biological Monitoring and Abatement Program for East Fork Poplar Creek

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinzman, R.L.; Adams, S.M.; Black, M.C.

1993-06-01

As stipulated in the National Pollutant Discharge Elimination System (NDPES) permit issued to the Oak Ridge Y-12 Plant on May 24, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream, East Fork Poplar Creek (EFPC). The objectives of BMAP are (1) to demonstrate that the current effluent limitations established for the Y-12 Plant protect the classified uses of EFPC (e.g., the growth and propagation of fish and aquatic life), as designated by the Tennessee Department of Environment and Conservation (TDEC) and (2) to document the ecological effects resulting from implementation of a Water Pollution Controlmore » Program that includes construction of several large wastewater treatment facilities. BMAP consists of four major tasks: (1) ambient toxicity testing; (2) bioaccumulation studies; (3) biological indicator studies; and (4) ecological surveys of stream communities, including periphyton (attached algae), benthic (bottom-dwelling) macroinvertebrates, and fish. This document, the second in a series of reports on the results of the Y-12 Plant BMAP, describes studies that were conducted between July 1986 and July 1988, although additional data collected outside this time period are included, as appropriate.« less

First report on the Oak Ridge Y-12 Plant Biological Monitoring and Abatement Program for East Fork Poplar Creek

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loar, J.M.; Adams, S.M.; Allison, L.J.

1992-07-01

As stipulated in the National Pollutant Discharge Elimination System (NPDES) permit issued to the Oak Ridge Y-12 Plant on May 24, 1985, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream, East Fork Poplar Creek (EFPC). The objectives of the BMAP are (1) to demonstrate that the current effluent limitations established for the Oak Ridge Y-12 Plant protect the uses of EFPC (e.g., the growth and propagation of fish and aquatic life), as designated by the Tennessee Department of Environment and Conservation (TDEC) [formerly the Tennessee Department of Health and Environment (TDHE)], and (2) to documentmore » the ecological effects resulting from implementation of a water pollution control program that includes construction of several large wastewater treatment facilities. The BMAP consists of four major tasks: (1) ambient toxicity testing, (2) bioaccumulation studies, (3) biological indicator studies, and (4) ecological surveys of stream communities, including periphyton (attached algae), benthic macroinvertebrates, and fish. This document, the first in a series of reports on the results of the Y-12 Plant BMAP, describes studies that were conducted from May 1985 through September 1986.« less

Mercury Remediation Technology Development for Lower East Fork Poplar Creek - FY 2016 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, Johnbull O.; Smith, John G.; Mehlhorn, Tonia L.

2017-07-01

Mercury remediation is a high priority for the US Department of Energy (DOE) Oak Ridge Office of Environmental Management (OREM), especially at and near the Y-12 National Security Complex (Y-12) where historical mercury use has resulted in contaminated buildings, soils, and downstream surface waters. To address mercury contamination of East Fork Poplar Creek (EFPC), the DOE has adopted a phased, adaptive management approach to remediation, which includes mercury treatment actions at Y-12 in the short-term and research and technology development (TD) to evaluate longer-term solutions in the downstream environment (US Department of Energy 2014).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erhart, Steven C.; Spencer, Charles G.

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA) vision for a commitment to energy effi ciency and sustainability and to achievement of the Guiding Principles. Specifi cally, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan (SSPP), while promoting overall sustainability and reduction of greenhouse gas (GHG) emissions. The mission of the Y-12 Energy Management program is to incorporate energy-efficient technologies site-wide and to position Y-12more » to meet NNSA energy requirement needs through 2025 and beyond. This plan addresses: Greenhouse Gas Reduction and Comprehensive Greenhouse Gas Inventory; Buildings, ESPC Initiative Schedule, and Regional and Local Planning; Fleet Management; Water Use Efficiency and Management; Pollution Prevention and Waste Reduction; Sustainable Acquisition; Electronic Stewardship and Data Centers; Renewable Energy; Climate Change; and Budget and Funding.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC; Environmental Compliance Department Environment, Safety, and Health Division Y-12 National Security Complex

This document presents the Groundwater Protection Program (GWPP) management plan for the U.S. Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12). The Y-12 GWPP functions as the primary point-of-contact for groundwater-related issues at Y-12, provides stewardship of the extensive network of groundwater monitoring wells at Y-12, and serves as a resource for technical expertise, support, and historical data for groundwater-related activities at Y-12. These organizational functions each serve the primary programmatic purpose of the GWPP, which is to ensure that groundwater monitoring activities within areas under Y-12 administrative control provide representative data in compliance with themore » multiple purposes of applicable state and federal regulations, DOE orders, and the corporate policies of BWXT Y-12, L.L.C. (hereafter referenced as BWXT), the Y-12 management and operations (M&O) contractor for DOE. This GWPP management plan addresses the requirements of DOE Order 450.1 (BWXT Y12 S/RID) regarding the implementation of a site-wide approach for groundwater protection at each DOE facility. Additionally, this plan is a ''living'' document that is reviewed annually, revised and reissued every three years, and is formatted to provide for updating individual sections independent of the rest of the document. Section 2 includes a short description of the groundwater system at Y-12, the history of groundwater monitoring at Y-12 and the corresponding evolution of the GWPP, and an overview of ongoing Y-12 groundwater monitoring activities. Section 3 describes the key elements of the GWPP management strategy. Organizational roles and responsibilities of GWPP personnel are outlined in Section 4. Section 5 presents an overview of the GWPP project plans for applicable programmatic elements. Section 6 lists the reports, plans, and documents that are referenced for technical and administrative details.« less

77 FR 23300 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Order Approving a Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

...-Regulatory Organizations; BATS Y-Exchange, Inc.; Order Approving a Proposed Rule Change To Amend BATS Y-Exchange, Inc. Rule 2.12 to Make Permanent the Pilot Program That Permits BATS Y-Exchange, Inc. To Receive Inbound Routes of Equities Orders Through BATS Trading, Inc., BATS Y-Exchange's Routing Broker-Dealer...

Technology Evaluation for the Big Spring Water Treatment System at the Y-12 National Security Complex, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becthel Jacobs Company LLC

2002-11-01

The Y-12 National Security Complex (Y-12 Complex) is an active manufacturing and developmental engineering facility that is located on the U.S. Department of Energy (DOE) Oak Ridge Reservation. Building 9201-2 was one of the first process buildings constructed at the Y-12 Complex. Construction involved relocating and straightening of the Upper East Fork Poplar Creek (UEFPC) channel, adding large quantities of fill material to level areas along the creek, and pumping of concrete into sinkholes and solution cavities present within the limestone bedrock. Flow from a large natural spring designated as ''Big Spring'' on the original 1943 Stone & Webster Buildingmore » 9201-2 Field Sketch FS6003 was captured and directed to UEFPC through a drainpipe designated Outfall 51. The building was used from 1953 to 1955 for pilot plant operations for an industrial process that involved the use of large quantities of elemental mercury. Past operations at the Y-12 Complex led to the release of mercury to the environment. Significant environmental media at the site were contaminated by accidental releases of mercury from the building process facilities piping and sumps associated with Y-12 Complex mercury handling facilities. Releases to the soil surrounding the buildings have resulted in significant levels of mercury in these areas of contamination, which is ultimately transported to UEFPC, its streambed, and off-site. Bechtel Jacobs Company LLC (BJC) is the DOE-Oak Ridge Operations prime contractor responsible for conducting environmental restoration activities at the Y-12 Complex. In order to mitigate the mercury being released to UEFPC, the Big Spring Water Treatment System will be designed and constructed as a Comprehensive Environmental Response, Compensation, and Liability Act action. This facility will treat the combined flow from Big Spring feeding Outfall 51 and the inflow now being processed at the East End Mercury Treatment System (EEMTS). Both discharge to UEFPC adjacent to Bldg. 9201-2. The EEMTS treats mercury-contaminated groundwater that collects in sumps in the basement of Bldg. 9201-2. A pre-design study was performed to investigate the applicability of various treatment technologies for reducing mercury discharges at Outfall 51 in support of the design of the Big Spring Water Treatment System. This document evaluates the results of the pre-design study for selection of the mercury removal technology for the treatment system.« less

Impact of payments for environmental services and protected areas on local livelihoods and forest conservation in northern Cambodia

PubMed Central

Clements, Tom; Milner-Gulland, E J

2015-01-01

The potential impacts of payments for environmental services (PES) and protected areas (PAs) on environmental outcomes and local livelihoods in developing countries are contentious and have been widely debated. The available evidence is sparse, with few rigorous evaluations of the environmental and social impacts of PAs and particularly of PES. We measured the impacts on forests and human well-being of three different PES programs instituted within two PAs in northern Cambodia, using a panel of intervention villages and matched controls. Both PES and PAs delivered additional environmental outcomes relative to the counterfactual: reducing deforestation rates significantly relative to controls. PAs increased security of access to land and forest resources for local households, benefiting forest resource users but restricting households’ ability to expand and diversify their agriculture. The impacts of PES on household well-being were related to the magnitude of the payments provided. The two higher paying market-linked PES programs had significant positive impacts, whereas a lower paying program that targeted biodiversity protection had no detectable effect on livelihoods, despite its positive environmental outcomes. Households that signed up for the higher paying PES programs, however, typically needed more capital assets; hence, they were less poor and more food secure than other villagers. Therefore, whereas the impacts of PAs on household well-being were limited overall and varied between livelihood strategies, the PES programs had significant positive impacts on livelihoods for those that could afford to participate. Our results are consistent with theories that PES, when designed appropriately, can be a powerful new tool for delivering conservation goals whilst benefiting local people. El Impacto de los Pagos por Servicios Ambientales y Áreas Protegidas sobre la Subsistencia Local y la Conservación del Bosque en el Norte de Camboya Resumen Los impactos potenciales de los pagos por servicios ambientales (PSA) y áreas protegidas (APs) sobre los resultados ambientales y las subsistencias locales en los países en desarrollo son polémicos y se han debatido ampliamente. La evidencia disponible es escasa; ha habido pocas evaluaciones rigurosas de los impactos ambientales y sociales de las APs y particularmente los PSA. Medimos el impacto sobre los bosques y el bienestar humano en tres diferentes programas de PSA que se llevan a cabo dentro de dos APs en el norte de Camboya usando un panel de aldeas de intervención y controles emparejados. Tanto los PSA como las APs brindaron resultados ambientales adicionales en relación a los contrafácticos, esto quiere decir que redujeron las tasas de deforestación significativamente en relación a los controles. Las áreas protegidas incrementaron el acceso seguro a los recursos del suelo y el bosque para las viviendas locales, beneficiando a los usuarios de los recursos del bosque pero restringiendo la habilidad de las viviendas para expandirse y diversificar su agricultura. Los impactos de los pagos por servicios ambientales sobre el bienestar de las viviendas estuvieron relacionados con la magnitud de los pagos proporcionados. Los dos programas de PSA de mayor paga y con conexión al mercado tuvieron impactos positivos significativos, mientras que un programa de menor paga con el objetivo de proteger a la biodiversidad no tuvo un efecto detectable sobre las viviendas, a pesar de sus resultados ambientales positivos. Las viviendas que se inscribieron a los programas de PSA con mayor paga, sin embargo, necesitaban típicamente más bienes capitales, por lo que eran menos pobres y tenían mayor seguridad alimentaria que otros aldeanos. Por esto, mientras los impactos de las APs sobre el bienestar de las viviendas fueron limitados en general y variaron dependiendo de las estrategias de subsistencia, los programas de PSA tuvieron impactos positivos significativos sobre las viviendas para aquellos que podían costear participar. Nuestros resultados son congruentes con las teorías de que los PSA, cuando se designan apropiadamente, pueden ser una herramienta poderosa y novedosa para obtener objetivos de conservación mientras se beneficia a la gente local. PMID:25492724

Chemical reactivity testing for the National Spent Nuclear Fuel Program. Revision 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koester, L.W.

This quality assurance project plan (QAPjP) summarizes requirements used by Lockheed Martin Energy Systems, Incorporated (LMES) Development Division at Y-12 for conducting chemical reactivity testing of Department of Energy (DOE) owned spent nuclear fuel, sponsored by the National Spent Nuclear Fuel Program (NSNFP). The requirements are based on the NSNFP Statement of work PRO-007 (Statement of Work for Laboratory Determination of Uranium Hydride Oxidation Reaction Kinetics.) This QAPjP will utilize the quality assurance program at Y-12, Y60-101PD, Quality Program Description, and existing implementing procedures for the most part in meeting the NSNFP Statement of Work PRO-007 requirements, exceptions will bemore » noted. The project consists of conducting three separate series of related experiments, ''Passivation of Uranium Hydride Powder With Oxygen and Water'', '''Passivation of Uranium Hydride Powder with Surface Characterization'', and ''Electrochemical Measure of Uranium Hydride Corrosion Rate''.« less

DEMONSTRATION BULLETIN: CIRCULATING BED COMBUSTOR - OGDEN ENVIRONMENTAL SERVICES, INC.

EPA Science Inventory

An evaluation of the Ogden Environmental Services (OES) circulating bed combustor (CBC) technology was carried out under the superfund Innovative Technology Evaluation (SITE) Program to determine its applicabilitY as an on-site treatment method for waste site cleanups, and more s...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plemons, R.E.; Hopwood, W.H. Jr.; Hamilton, J.H.

For a number of years the Oak Ridge Y-12 Plant Laboratory has been analyzing coal predominately for the utilities department of the Y-12 Plant. All laboratory procedures, except a Leco sulfur method which used the Leco Instruction Manual as a reference, were written based on the ASTM coal analyses. Sulfur is analyzed at the present time by two methods, gravimetric and Leco. The laboratory has two major endeavors for monitoring the quality of its coal analyses. (1) A control program by the Plant Statistical Quality Control Department. Quality Control submits one sample for every nine samples submitted by the utilitiesmore » departments and the laboratory analyzes a control sample along with the utilities samples. (2) An exchange program with the DOE Coal Analysis Laboratory in Bruceton, Pennsylvania. The Y-12 Laboratory submits to the DOE Coal Laboratory, on even numbered months, a sample that Y-12 has analyzed. The DOE Coal Laboratory submits, on odd numbered months, one of their analyzed samples to the Y-12 Plant Laboratory to be analyzed. The results of these control and exchange programs are monitored not only by laboratory personnel, but also by Statistical Quality Control personnel who provide statistical evaluations. After analysis and reporting of results, all utilities samples are retained by the laboratory until the coal contracts have been settled. The utilities departments have responsibility for the initiation and preparation of the coal samples. The samples normally received by the laboratory have been ground to 4-mesh, reduced to 0.5-gallon quantities, and sealed in air-tight containers. Sample identification numbers and a Request for Analysis are generated by the utilities departments.« less

Developing an Environmental Education Program, K-12.

ERIC Educational Resources Information Center

Stapp, William B.; Visse, Ellen Vande

Strategy for developing and implementing an environmental education program in grades K-12 is proposed in this booklet. Its goal is to help students become environmentally educated decision-makers; to understand the importance of relating ecological, economic, social, technological, and political information when working toward the solution of…

Results of calendar year 1994 monitor well inspection and maintenance program, Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMaster, B.W.; Jones, S.B.; Sitzler, J.L.

1995-06-01

This document is a compendium of results of the calendar year 1994 Monitor Well Inspection and Maintenance Program at the Department of Energy Y-12 Plant in Oak Ridge, Tennessee. This report documents the work relating to well inspections and maintenance requests. Inspections are implemented in order to better assess the condition and maintenance needs of wells that are actively being monitored. Currently this approach calls for inspecting all wells on a routine (annual or triennial) basis which are: (1) in an active sampling program; (2) included in a hydrologic study; or (3) not in service, but not scheduled for pluggingmore » and abandonment. Routine inspections help to ensure that representative groundwater samples and hydrologic data are being collected, and contribute to the life expectancy of each well. This report formally presents well inspection and maintenance activities that were conducted at the Y-12 Plant during 1994. All inspections were conducted between April and December.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, J.G.; Patterson, A.L.; Wiginton, M.C.

BWXT Y-12, L.L.C., the Maintenance and Operations (M and O) contractor at the Y-12 National Security Complex (Y-12), practices pollution prevention in daily operations because it recognizes that the implementation of pollution prevention (P2) projects impacting all waste types, discharges, and emissions at the complex saves resources across the board. Projects that reduce solid industrial waste save numerous resources, including valuable landfill space. At Y- 12, most of the solid industrial waste that is not reduced, reused, or recycled is transported to an industrial waste landfill located on the U.S. Department of Energy (DOE) Oak Ridge Reservation (ORR). While themore » current landfill still has capacity, in the past the industrial waste generation across the ORR was impacted when the new landfill was not available to receive waste, but the old landfill was reaching capacity. The potential of having waste with absolutely nowhere to go is simply not an option for a facility with ongoing operations. Avoiding this potential scenario in the memorable past has made Y-12 very aware of the importance of reducing all waste types. While Y-12 aggressively pursues pollution prevention implementation on all waste types, this paper will highlight the use of systems, people, and pollution prevention integration in projects used by Y-12 to holistically reduce the amount of industrial waste being sent to the on-site landfill. Specifically, the design and use of Y-12's Environmental Management System (EMS), the creation of a multi-disciplinary team, and the buy-in and creativity of the site project, Infrastructure Reduction (IR), that generates the largest volumes of waste will be discussed. (authors)« less

Potential environmental benefits from increased use of bioenergy in China.

PubMed

Fan, Shuyang; Freedman, Bill; Gao, Jixi

2007-09-01

Because of its large population and rapidly growing economy, China is confronting a serious energy shortage and daunting environmental problems. An increased use of fuels derived from biomass could relieve some demand for nonrenewable sources of energy while providing environmental benefits in terms of cleaner air and reduced emissions of greenhouse gases. In 2003, China generated about 25.9 x 10(8) metric tons of industrial waste (liquid + solid), 14.7 x 10(8) metric tons/year (t/y) of manure (livestock + human), 7.1 x 10(8) t/y of crop residues and food-processing byproducts, 2 x 10(8) t/y of fuelwood and wood manufacturing residues, and 1.5 x 10(8) t/y of municipal waste. Biofuels derived from these materials could potentially displace the use of about 4.12 x 10(8) t/y of coal and 3.75 x 10(6) t/y of petroleum. An increased bioenergy use of this magnitude would help to reduce the emissions of key air pollutants: SO(2 )by 11.6 x 10(6) t/y, NO(X) by 1.48 x 10(6) t/y, CO2 by 1.07 x 10(9) t/y, and CH4 by 50 x 10(6) t/y. The reduced SO(2) emissions would be equivalent to 54% of the national emissions in 2003, whereas those for CO2 are 30%. It is important to recognize, however, that large increases in the use of biomass fuels also could result in socioeconomic and environmental problems such as less production of food and damage caused to natural habitats.

Potential Environmental Benefits from Increased Use of Bioenergy in China

NASA Astrophysics Data System (ADS)

Fan, Shuyang; Freedman, Bill; Gao, Jixi

2007-09-01

Because of its large population and rapidly growing economy, China is confronting a serious energy shortage and daunting environmental problems. An increased use of fuels derived from biomass could relieve some demand for nonrenewable sources of energy while providing environmental benefits in terms of cleaner air and reduced emissions of greenhouse gases. In 2003, China generated about 25.9 × 108 metric tons of industrial waste (liquid + solid), 14.7 × 108 metric tons/year (t/y) of manure (livestock + human), 7.1 × 108 t/y of crop residues and food-processing byproducts, 2 × 108 t/y of fuelwood and wood manufacturing residues, and 1.5 × 108 t/y of municipal waste. Biofuels derived from these materials could potentially displace the use of about 4.12 × 108 t/y of coal and 3.75 × 106 t/y of petroleum. An increased bioenergy use of this magnitude would help to reduce the emissions of key air pollutants: SO2 by 11.6 × 106 t/y, NOX by 1.48 × 106 t/y, CO2 by 1.07 × 109 t/y, and CH4 by 50 × 106 t/y. The reduced SO2 emissions would be equivalent to 54% of the national emissions in 2003, whereas those for CO2 are 30%. It is important to recognize, however, that large increases in the use of biomass fuels also could result in socioeconomic and environmental problems such as less production of food and damage caused to natural habitats.

Storm water runoff for the Y-12 Plant and selected parking lots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, E.T.

1996-01-01

A comparison of storm water runoff from the Y-12 Plant and selected employee vehicle parking lots to various industry data is provided in this document. This work is an outgrowth of and part of the continuing Non-Point Source Pollution Elimination Project that was initiated in the late 1980s. This project seeks to identify area pollution sources and remediate these areas through the Resource Conservation and Recovery Act/Comprehensive Environmental Response, Compensation, and Liability Act (RCRA/CERCLA) process as managed by the Environmental Restoration Organization staff. This work is also driven by the Clean Water Act Section 402(p) which, in part, deals withmore » establishing a National Pollutant Discharge Elimination System (NPDES) permit for storm water discharges. Storm water data from events occurring in 1988 through 1991 were analyzed in two reports: Feasibility Study for the Best Management Practices to Control Area Source Pollution Derived from Parking Lots at the DOE Y-12 Plant, September 1992, and Feasibility Study of Best Management Practices for Non-Point Source Pollution Control at the Oak Ridge Y-12 Plant, February 1993. These data consisted of analysis of outfalls discharging to upper East Fork Poplar Creek (EFPC) within the confines of the Y-12 Plant (see Appendixes D and E). These reports identified the major characteristics of concern as copper, iron, lead, manganese, mercury, nitrate (as nitrogen), zinc, biological oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), fecal coliform, and aluminum. Specific sources of these contaminants were not identifiable because flows upstream of outfalls were not sampled. In general, many of these contaminants were a concern in many outfalls. Therefore, separate sampling exercises were executed to assist in identifying (or eliminating) specific suspected sources as areas of concern.« less

40 CFR 190.12 - Effective date.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Effective date. 190.12 Section 190.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR NUCLEAR POWER OPERATIONS Environmental Standards for the...

40 CFR 190.12 - Effective date.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Effective date. 190.12 Section 190.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR NUCLEAR POWER OPERATIONS Environmental Standards for the...

40 CFR 190.12 - Effective date.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Effective date. 190.12 Section 190.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR NUCLEAR POWER OPERATIONS Environmental Standards for the...

40 CFR 190.12 - Effective date.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Effective date. 190.12 Section 190.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR NUCLEAR POWER OPERATIONS Environmental Standards for the...

Environmental Technology.

ERIC Educational Resources Information Center

Columbus State Community Coll., OH.

This document contains materials developed for and about the environmental technology tech prep program of the South-Western City Schools in Ohio. Part 1 begins with a map of the program, which begins with an environmental science technology program in grades 11 and 12 that leads to entry-level employment or a 2-year environmental technology…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherry, T D; Kohlhorst, D P; Little, S K

The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the DOE and the National Nuclear Security Administration (NNSA) vision for a commitment to energy efficiency and sustainability and to achievement of the Guiding Principles. Specifically, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan (SSPP) while promoting overall sustainability and reduction of greenhouse gas (GHG) emissions. Table ES.2 gives a comprehensive overview of Y-12's performance status and planned actions. B&W Y-12's Energy Management mission is to incorporate renewable energy andmore » energy efficient technologies site-wide and to position Y-12 to meet NNSA energy requirement needs through 2025 and beyond. During FY 2011, the site formed a sustainability team (Fig. ES.1). The sustainability team provides a coordinated approach to meeting the various sustainability requirements and serves as a forum for increased communication and consistent implementation of sustainability activities at Y-12. The sustainability team serves as an information exchange mechanism to promote general awareness of sustainability information, while providing a system to document progress and to identify resources. These resources are necessary to implement activities that support the overall goals of sustainability, including reducing the use of resources and conserving energy. Additionally, the team's objectives include: (1) Foster a Y-12-wide philosophy to conserve resources; (2) Reduce the impacts of production operations in a cost-effective manner; (3) Increase materials recycling; (4) Use a minimum amount of energy and fuel; (5) Create a minimum of waste and pollution in achieving Y-12-strategic objectives; (6) Develop and implement techniques, technologies, process modifications, and programs that support sustainable acquisition; (7) Minimize the impacts to resources, including energy/fuel, water, waste, pesticides, and pollution generation; (8) Incorporate sustainable design principles into the design and construction of facility upgrades, new facilities, and infrastructure; and (9) Comply with federal and state regulations, executive orders, and DOE requirements. Y-12 is working to communicate its sustainment vision through procedural, engineering, operational, and management practices. The site will make informed decisions based on the application of the five Guiding Principles for HPSBs to the maximum extent possible.« less

Chemical Reactivity Testing for the National Spent Nuclear Fuel Program. Quality Assurance Project Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newsom, H.C.

This quality assurance project plan (QAPjP) summarizes requirements used by Lockheed Martin Energy Systems, Incorporated (LMES) Development Division at Y-12 for conducting chemical reactivity testing of Department of Energy (DOE) owned spent nuclear fuel, sponsored by the National Spent Nuclear Fuel Program (NSNFP). The requirements are based on the NSNFP Statement of Work PRO-007 (Statement of Work for Laboratory Determination of Uranium Hydride Oxidation Reaction Kinetics.) This QAPjP will utilize the quality assurance program at Y-12, QA-101PD, revision 1, and existing implementing procedures for the most part in meeting the NSNFP Statement of Work PRO-007 requirements, exceptions will be noted.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC

This plan provides a description of the groundwater and surface water quality monitoring activities planned for calendar year (CY) 2009 at the U.S. Department of Energy (DOE) Y-12 National Security Complex (Y-12) that will be managed by the Y-12 Groundwater Protection Program (GWPP). Groundwater and surface water monitoring performed by the GWPP during CY 2009 will be in accordance with DOE Order 540.1 requirements and the following goals: (1) to protect the worker, the public, and the environment; (2) to maintain surveillance of existing and potential groundwater contamination sources; (3) to provide for the early detection of groundwater contamination andmore » determine the quality of groundwater and surface water where contaminants are most likely to migrate beyond the Oak Ridge Reservation property line; (4) to identify and characterize long-term trends in groundwater quality at Y-12; and (5) to provide data to support decisions concerning the management and protection of groundwater resources. Groundwater and surface water monitoring during CY 2009 will be performed primarily in three hydrogeologic regimes at Y-12: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime), and the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valley, and the Chestnut Ridge Regime is located south of Y-12 (Figure A.1). Additional surface water monitoring will be performed north of Pine Ridge, along the boundary of the Oak Ridge Reservation. Modifications to the CY 2009 monitoring program may be necessary during implementation. Changes in programmatic requirements may alter the analytes specified for selected monitoring wells or may add or remove wells from the planned monitoring network. All modifications to the monitoring program will be approved by the Y-12 GWPP manager and documented as addenda to this sampling and analysis plan. The following sections of this report provide details regarding the CY 2009 groundwater and surface water monitoring activities. Section 2 describes the monitoring locations in each regime and the processes used to select the sampling locations. A description of the field measurements and laboratory analytes is provided in Section 3; sample collection methods and procedures are described in Section 4; and Section 5 lists the documents cited for more detailed operational and technical information.« less

Underground storage tank management plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-09-01

The Underground Storage Tank (UST) Management Program at the Oak Ridge Y-12 Plant was established to locate UST systems in operation at the facility, to ensure that all operating UST systems are free of leaks, and to establish a program for the removal of unnecessary UST systems and upgrade of UST systems that continue to be needed. The program implements an integrated approach to the management of UST systems, with each system evaluated against the same requirements and regulations. A common approach is employed, in accordance with Tennessee Department of Environment and Conservation (TDEC) regulations and guidance, when corrective actionmore » is mandated. This Management Plan outlines the compliance issues that must be addressed by the UST Management Program, reviews the current UST inventory and compliance approach, and presents the status and planned activities associated with each UST system. The UST Management Plan provides guidance for implementing TDEC regulations and guidelines for petroleum UST systems. (There are no underground radioactive waste UST systems located at Y-12.) The plan is divided into four major sections: (1) regulatory requirements, (2) implementation requirements, (3) Y-12 Plant UST Program inventory sites, and (4) UST waste management practices. These sections describe in detail the applicable regulatory drivers, the UST sites addressed under the Management Program, and the procedures and guidance used for compliance with applicable regulations.« less

Mercury Remediation Technology Development for Lower East Fork Poplar Creek - FY 2015 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Mark J.; Brooks, Scott C.; Mathews, Teresa J.

2016-04-01

Mercury remediation is a high priority for the US Department of Energy (DOE) Oak Ridge Office of Environmental Management (OREM) because of large historical losses of mercury within buildings and to soils and surface waters at the Y-12 National Security Complex (Y-12). Because of the extent of mercury losses and the complexities of mercury transport and fate in the downstream environment, the success of conventional options for mercury remediation in lower East Fork Poplar Creek (EFPC) is uncertain. A phased, adaptive management approach to remediation of surface water includes mercury treatment actions at Y-12 in the short-term and research andmore » technology development (TD) to evaluate longer-term solutions in the downstream environment (US Department of Energy 2014b).« less

Steerability Analysis of Tracked Vehicles: Theory and User’s Guide for Computer Program TVSTEER

DTIC Science & Technology

1986-08-01

Baladi , Donald E. Barnes, Rebecca P. BergerC oStructures Laboratory NDEPARTMENT OF THE ARMY ___ Waterways Experiment Station, Corps of Engineers . U P0 Box...Analysis of Tracked Vehicles: Theory and User’s Guide for Computer Program TVSTEER - 12 PERSONAL AUTHOR(S) Baladi , George Y., Barnes, Donald E...mathematical model was formulated by Drs. George Y. Baladi and Behzad Rohani. The logic and computer programming were accomplished by Dr. Baladi and

Notification: Hotline Complaint Regarding the EPA Region 4 Environmental Justice Program

EPA Pesticide Factsheets

Project #OPE-FY12-0017, September 17, 2012. We have completed the preliminary research portion ofour evaluation, Hotline Complaint Regarding the EPA Region 4 Environmental Justice Program (OPE FY12-0017) and will now continue into the fieldwork phase.

Y-12 Groundwater Protection Program Groundwater and Surface water Sampling and Analysis Plan for Calendar Year 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

N /A

2006-01-01

This plan provides a description of the groundwater and surface water quality monitoring activities planned for calendar year (CY) 2006 at the U.S. Department of Energy (DOE) Y-12 National Security Complex (Y-12) that will be managed by the Y-12 Groundwater Protection Program (GWPP). Groundwater and surface water monitoring performed by the GWPP during CY 2006 will be in accordance with DOE Order 540.1 requirements and the following goals: {sm_bullet} to maintain surveillance of existing and potential groundwater contamination sources; {sm_bullet} to provide for the early detection of groundwater contamination and determine the quality of groundwater and surface water where contaminantsmore » are most likely to migrate beyond the Oak Ridge Reservation property line; {sm_bullet} to identify and characterize long-term trends in groundwater quality at Y-12; and ! to provide data to support decisions concerning the management and protection of groundwater resources. Groundwater and surface water monitoring during CY 2006 will be performed primarily in three hydrogeologic regimes at Y-12: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime), and the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valley, and the Chestnut Ridge Regime is located south of Y-12 (Figure A.1). Additional surface water monitoring will be performed north of Pine Ridge, along the boundary of the Oak Ridge Reservation (Figure A.1). Modifications to the CY 2006 monitoring program may be necessary during implementation. Changes in programmatic requirements may alter the analytes specified for selected monitoring wells or may add or remove wells from the planned monitoring network. All modifications to the monitoring program will be approved by the Y-12 GWPP manager and documented as addenda to this sampling and analysis plan. The following sections of this report provide details regarding the CY 2006 groundwater and surface water monitoring activities. Section 2 describes the monitoring locations in each regime and the processes used to select the sampling locations. A description of the field measurements and laboratory analytes is provided in Section 3; sample collection methods and procedures are described in Section 4; and Section 5 lists the documents cited for more detailed operational and technical information. The narrative sections of the report reference several appendices. Figures (maps and diagrams) and tables (excluding data summary tables presented in the narrative sections) are in Appendix A and Appendix B, respectively. The monitoring frequency and selection criteria for each sampling location is in Appendix C. Laboratory requirements (bottle lists, holding times, etc.) are provided in Appendix D. If issued, addenda to this plan will be inserted in Appendix E, and Groundwater Monitoring Schedules (when issued) will be inserted in Appendix F. Guidance for managing purged groundwater is provided in Appendix G.« less

Y-12 Groundwater Protection Program Groundwater And Surface Water Sampling And Analysis Plan For Calendar Year 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC

2009-09-01

This plan provides a description of the groundwater and surface water quality monitoring activities planned for calendar year (CY) 2010 at the U.S. Department of Energy (DOE) Y-12 National Security Complex (Y-12) that will be managed by the Y-12 Groundwater Protection Program (GWPP). Groundwater and surface water monitoring performed by the GWPP during CY 2010 will be in accordance with requirements of DOE Order 540.1A and the following goals: (1) to protect the worker, the public, and the environment; (2) to maintain surveillance of existing and potential groundwater contamination sources; (3) to provide for the early detection of groundwater contaminationmore » and determine the quality of groundwater and surface water where contaminants are most likely to migrate beyond the Oak Ridge Reservation property line; (4) to identify and characterize long-term trends in groundwater quality at Y-12; and (5) to provide data to support decisions concerning the management and protection of groundwater resources. Groundwater and surface water monitoring during CY 2010 will be performed primarily in three hydrogeologic regimes at Y-12: the Bear Creek Hydrogeologic Regime (Bear Creek Regime), the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime), and the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Bear Creek and East Fork regimes are located in Bear Creek Valley, and the Chestnut Ridge Regime is located south of Y-12 (Figure A.1). Additional surface water monitoring will be performed north of Pine Ridge, along the boundary of the Oak Ridge Reservation. Modifications to the CY 2010 monitoring program may be necessary during implementation. Changes in programmatic requirements may alter the analytes specified for selected monitoring wells or may add or remove wells from the planned monitoring network. All modifications to the monitoring program will be approved by the Y-12 GWPP manager and documented as addenda to this sampling and analysis plan. The following sections of this report provide details regarding the CY 2010 groundwater and surface water monitoring activities. Section 2 describes the monitoring locations in each regime and the processes used to select the sampling locations. A description of the field measurements and laboratory analytes is provided in Section 3. Sample collection methods and procedures are described in Section 4, and Section 5 lists the documents cited for more detailed operational and technical information. The narrative sections of the report reference several appendices. Figures (maps and diagrams) and tables (excluding data summary tables presented in the narrative sections) are in Appendix A and Appendix B, respectively. Groundwater Monitoring Schedules (when issued throughout CY 2010) will be inserted in Appendix C, and addenda to this plan (if issued) will be inserted in Appendix D. Laboratory requirements (bottle lists, holding times, etc.) are provided in Appendix E, and an approved Waste Management Plan is provided in Appendix F.« less

Formerly Utilized Sites Remedial Action Program (FUSRAP) Hazelwood Interim Storage Site annual site environmental report. Calendar year 1985. [FUSRAP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-04-01

The Hazelwood Interim Storage Site (HISS) is presently used for the storage of low-level radioactively contaminated soils. Monitoring results show that the HISS is in compliance with DOE concentration guides and radiation protection standards. Derived Concentration Guides (DCGs) represent the concentrations of radionuclides in air or water that would limit the radiation dose to 100 mrem/y. The applicable limits have been revised since the 1984 environmental monitoring report was published. The limits applied in 1984 were based on a radiation protection standard of 500 mrem/y; the limits applied for 1985 are based on a standard of 100 mrem/y. The HISSmore » is part of the Formerly Utilized Sites Remedial Action Program (FUSRAP), a DOE program to decontaminate or otherwise control sites where low-level radioactive contamination remains from the early years of the nation's atomic energy program. To determine whether the site is in compliance with DOE standards, environmental measurements are expressed as percentages of the applicable DCG, while the calculated doses to the public are expressed as percentages of the applicable radiation protection standard. The monitoring program at the HISS measures uranium, radium, and thorium concentrations in surface water, groundwater, and sediment; radon gas concentrations in air; and external gamma radiation exposure rates. Potential radiation doses to the public are also calculated. The HISS was designated for remedial action under FUSRAP because radioactivity above applicable limits was found to exist at the site and its vicinity. Elevated levels of radiation still exist in areas where remedial action has not yet been completed.« less

PROGRAMA PARA LA VERIFICACIN DE LA TECNOLOGIA AMBIENTAL/ENVIRONMENTAL TECHNOLOGY VERIFICATION PROGRAM (ETV) (EPA/600/F-98/015A)

EPA Science Inventory

A travs de su historia, la Agencia de Proteccin del Medio Ambiente estadounidense (U.S. Environmental Protection Agency, EPA) ha evaluado distintas tecnologas para determinar su efectividad en el monitoreo, la prevencin, el control, y la limpieza de la contaminacin ambiental. Sin...

Effects of a Supported Speed Treadmill Training Exercise Program on Impairment and Function for Children with Cerebral Palsy

ERIC Educational Resources Information Center

Johnston, Therese E.; Watson, Kyle E.; Ross, Sandy A.; Gates, Philip E.; Gaughan, John P.; Lauer, Richard T.; Tucker, Carole A.; Engsberg, Jack R.

2011-01-01

Aim: To compare the effects of a supported speed treadmill training exercise program (SSTTEP) with exercise on spasticity, strength, motor control, gait spatiotemporal parameters, gross motor skills, and physical function. Method: Twenty-six children (14 males, 12 females; mean age 9y 6mo, SD 2y 2mo) with spastic cerebral palsy (CP; diplegia, n =…

Soil Investigation of Lower East Fork Poplar Creek

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, Johnbull O.; Mayes, Melanie; Earles, Jennifer E.

2017-03-01

Mercury is regarded by the US Department of Energy (DOE) Oak Ridge Office of Environmental Management as a priority contaminant on the Oak Ridge Reservation because of the environmental risks associated with substantial losses from buildings, soils, and surface waters at the Y-12 National Security Complex (Y-12). As a result of historical releases of mercury from Y-12 primarily in the 1950s and early 1960s, the lower East Fork Poplar Creek (LEFPC) stream channel and bank soil margins are contaminated with mercury (Brooks and Southworth 2011; Tennessee Valley Authority 1985b, a). A Mercury Remediation Technology Development project is underway to evaluatemore » the nature of downstream mercury contamination and to develop targeted site-specific remedial technologies that can mitigate mercury release and biological uptake. It is known that mercury concentration varies longitudinally and with depth in LEFPC bank soils; however, soil types and soil physical properties are not well known, especially relative to the zones of mercury contamination. Moreover, there are no soil maps for the downstream reaches of LEFPC in Roane County (i.e. from the Chestnut Hill Road downstream) and this work represents the first ever soil mapping along this section of LEFPC.« less

40 CFR 610.12 - Program initiative.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

40 CFR 610.12 - Program initiative.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

40 CFR 610.12 - Program initiative.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

40 CFR 610.12 - Program initiative.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

Electrochromic material and electro-optical device using same

DOEpatents

Cogan, S.F.; Rauh, R.D.

1992-01-14

An oxidatively coloring electrochromic layer of composition M[sub y]CrO[sub 2+x] (0.33[le]y[le]2.0 and x[le]2) where M=Li, Na or K with improved transmittance modulation, improved thermal and environmental stability, and improved resistance to degradation in organic liquid and polymeric electrolytes. The M[sub y]CrO[sub 2+x] provides complementary optical modulation to cathodically coloring materials in thin-film electrochromic glazings and electrochromic devices employing polymeric Li[sup +] ion conductors. 12 figs.

The effectiveness of a community health program in improving diabetes knowledge in the Hispanic population: Salud y Bienestar (Health and Wellness).

PubMed

Cruz, Yanira; Hernandez-Lane, Maria-Eugenia; Cohello, Janet I; Bautista, Christian T

2013-12-01

We evaluated the effectiveness of the Salud y Bienestar program to deliver diabetes education in the Hispanic population in the United States. This program uses a community outreach model where community health promoters are trained and then they deliver education to other community members regarding diabetes disease, risk factors, and ways to prevent and control disease. This intervention applies a one-group pre- and post-test design to improve diabetes knowledge. The intervention carried out in the states of California, Texas, and Washington DC. A total of 1,413 participants were enrolled. Of these, 73% were females, 46% were 65 years or older, 59% were Mexican, 64% had at least elementary education, 56% had lived in the US for more than 20 years, and 38% participants were self-reported diabetic. Among diabetic participants, a significant improvement was observed on diabetes knowledge when comparing pre- and post-test scores (13.7 vs. 18.6, P < 0.001; Cohen's d = 1.2). Among non-diabetic participants, diabetes knowledge also increased significantly after one-single training session (12.9 vs. 18.2, P < 0.001; Cohen's d = 1.2). The Salud y Bienestar program conducted by community health workers was effective approach to improving diabetes knowledge in the Hispanic population.

Proceedings of the IMOG (Interagency Manufacturing Operations Group) Numerical Systems Group. 62nd Meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maes, G.J.

1993-10-01

This document contains the proceedings of the 62nd Interagency Manufacturing Operations Group (IMOG) Numerical Systems Group. Included are the minutes of the 61st meeting and the agenda for the 62nd meeting. Presentations at the meeting are provided in the appendices to this document. Presentations were: 1992 NSG Annual Report to IMOG Steering Committee; Charter for the IMOG Numerical Systems Group; Y-12 Coordinate Measuring Machine Training Project; IBH NC Controller; Automatically Programmed Metrology Update; Certification of Anvil-5000 for Production Use at the Y-12 Plant; Accord Project; Sandia National Laboratories {open_quotes}Accord{close_quotes}; Demo/Anvil Tool Path Generation 5-Axis; Demo/Video Machine/Robot Animation Dynamics; Demo/Certification ofmore » Anvil Tool Path Generation; Tour of the M-60 Inspection Machine; Distributed Numerical Control Certification; Spline Usage Method; Y-12 NC Engineering Status; and Y-12 Manufacturing CAD Systems.« less

40 CFR 130.12 - Coordination with other programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

....12 Section 130.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY PLANNING AND MANAGEMENT § 130.12 Coordination with other programs. (a) Relationship... 208(e) of the Act, no NPDES permit may be issued which is in conflict with an approved Water Quality...

Y-12 National Security Complex Biological Monitoring and Abatement Program 2007 Calendar Yeare Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, M.J.; Greeley, M. S. Jr.; Morris, G. W.

2008-07-01

The National Pollutant Discharge Elimination System (NPDES) permit issued for the Oak Ridge Y-12 National Security Complex (Y-12 Complex) which became effective May 1, 2006, continued a requirement for a Biological Monitoring and Abatement Program (BMAP). The BMAP was originally developed in 1985 to demonstrate that the effluent limitations established for the Y-12 Complex protected the classified uses of the receiving stream (East Fork Poplar Creek: EFPC), in particular, the growth and propagation of aquatic life (Loar et al. 1989). The objectives of the current BMAP are similar, specifically to assess stream ecological conditions relative to regulatory limits and criteria,more » to assess ecological impacts as well as recovery in response to Y-12 operations, and to investigate the causes of continuing impacts. The BMAP consists of three tasks that reflect complementary approaches to evaluating the effects of the Y-12 Complex discharges on the biotic integrity of EFPC. These tasks include: (1) bioaccumulation monitoring, (2) benthic macroinvertebrate community monitoring, and (3) fish community monitoring. As required by the NPDES permit, the BMAP benthic macroinvertebrate community monitoring task includes studies to annually evaluate the receiving stream's biological integrity in comparison to TN Water Quality Criteria. BMAP monitoring is currently being conducted at five primary EFPC sites, although sites may be excluded or added depending upon the specific objectives of the various tasks. Criteria used in selecting the sites include: (1) location of sampling sites used in other studies, (2) known or suspected sources of downstream impacts, (3) proximity to U.S. Department of Energy (DOE) Oak Ridge Reservation (ORR) boundaries, (4) appropriate habitat distribution, and (5) access. The primary sampling sites include upper EFPC at kilometers (EFKs) 24.4 and 23.4 [upstream and downstream of Lake Reality (LR) respectively]; EFK 18.7 (also EFK 18.2 and 19), located off the ORR and below an area of intensive commercial and light industrial development; EFK 13.8, located upstream from the Oak Ridge Wastewater Treatment Facility (ORWTF); and EFK 6.3 located approximately 1.4 km below the ORR boundary (Fig. 1.1). Actual sampling locations on EFPC may differ slightly by task according to specific requirements of the task. Brushy Fork (BF) at kilometer (BFK) 7.6 and Hinds Creek at kilometer (HCK) 20.6 are the most commonly used reference sites for the Y-12 BMAP. Additional sites off the ORR are also occasionally used for reference, including Beaver Creek, Bull Run, Cox Creek, and Paint Rock Creek (Fig. 1.2). Summaries of the sampling designs for the three primary tasks of the Y-12 Complex BMAP for EFPC are presented in Tables 1.1-1.3. This report covers the 2007 study period, although data collected outside this time period are included as appropriate. To address the biological monitoring requirements for Bear Creek and McCoy Branch, CERCLA-funded data is summarized in Appendix A (for Bear Creek) and Appendix B (for McCoy Branch). Data for these two watersheds is provided herein to address Section IX of the NPDES Permit for Y-12, where 'Results of these CERCLA programs can be used to meet the biological monitoring requirements of this permit'. For potential comparison with instream biological measures, a summary of the toxicity testing results for Y-12 outfalls into upper EFPC is provided in Appendix C (these results have been previously reported).« less

Progress and Future Plans for Mercury Remediation at the Y-12 National Security Complex, Oak Ridge, Tennessee - 13059

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, Laura O.; DePaoli, Susan M.; Turner, Ralph

2013-07-01

The U.S. Department of Energy (DOE), along with the Tennessee Department of Environment and Conservation (TDEC) and the U.S. Environmental Protection Agency (EPA), has identified mercury contamination at the Y-12 National Security Complex (Y-12) as the highest priority cleanup risk on the Oak Ridge Reservation (ORR). The historic loss of mercury to the environment dwarfs any other contaminant release on the ORR. Efforts over the last 20 years to reduce mercury levels leaving the site in the surface waters of Upper East Fork Poplar Creek (UEFPC) have not resulted in a corresponding decrease in mercury concentrations in fish. Further reductionsmore » in mercury surface water concentrations are needed. Recent stimulus funding through the American Recovery and Reinvestment Act of 2009 (ARRA) has supported several major efforts involving mercury cleanup at Y-12. Near-term implementation activities are being pursued with remaining funds and include design of a centrally located mercury treatment facility for waterborne mercury, treatability studies on mercury-contaminated soils, and free mercury removal from storm drains. Out-year source removal will entail demolition/disposal of several massive uranium processing facilities along with removal and disposal of underlying contaminated soil. As a National Priorities List (NPL) site, cleanup is implemented under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and directed by the Federal Facility Agreement (FFA) between DOE, EPA, and TDEC. The CERCLA process is followed to plan, reach approval, implement, and monitor the cleanup. (authors)« less

Identification of novel transcriptional regulators of Zat12 using comprehensive yeast one-hybrid screens.

PubMed

Ben Daniel, Bat-Hen; Cattan, Esther; Wachtel, Chaim; Avrahami, Dorit; Glick, Yair; Malichy, Asaf; Gerber, Doron; Miller, Gad

2016-08-01

To appropriately acclimate to environmental stresses, plants have to rapidly activate a specific transcriptional program. Yet, the identity and function of many of the transcriptional regulators that mediate early responses to abiotic stress stimuli is still unknown. In this work we employed the promoter of the multi-stress-responsive zinc-finger protein Zat12 in yeast one-hybrid (Y1H) screens to identify early abiotic stress-responsive transcriptional regulators. Analysis of Zat12 promoter fragments fused to luciferase underlined an approximately 200 bp fragment responsive to NaCl and to reactive oxygen species (ROS). Using these segments and others as baits against Y1H control or stress Arabidopsis prey libraries, we identified 15 potential Zat12 transcriptional regulators. Among the prominent proteins identified were known transcription factors including bZIP29 and ANAC91 as well as unknown function proteins such as a homolog of the human USB1, a U6 small nuclear RNA (snRNA) processing protein, and dormancy/auxin-associated family protein 2 (DRM2). Altered expression of Zat12 during high light stress in the knockout mutants further indicated the involvement of these proteins in the regulation of Zat12. Using a state of the art microfluidic approach we showed that AtUSB1 and DRM2 can specifically bind dsDNA and were able to identify the preferred DNA-binding motif of all four proteins. Overall, the proteins identified in this work provide an important start point for charting the earliest signaling network of Zat12 and of other genes required for acclimation to abiotic stresses. © 2016 Scandinavian Plant Physiology Society.

La participacion de padres y madres en programas de desarrollo infantil temprano (Participation of Fathers and Mothers in Early Childhood Development Programs).

ERIC Educational Resources Information Center

Moreno Garcia, Teresa, Ed.

2001-01-01

This Spanish- and Portuguese-language bulletin presents articles covering child development programs with varying degrees of parent involvement. As explained in the bulletin's opening editorial, the articles focus on the keys to good parenting, influences such as the programs environmental context, goals and methods on the degree and manner of…

Development of a Multicriteria Decision Model for Prioritizing Air Force Environmental Restoration Program Projects

DTIC Science & Technology

1993-09-01

the Degree of Master of Science in Engineering and Environmental Management Thomas E. Ellingson, B.S. T. Gene Gallogly, B.S., M.B.A. September 1993... Science Advisory Board (SAB) notes: One tool that can help foster the evolution of an integrated and targeted national environmental policy is the...and Yacov Y. Haimes. Multiobjective Decision Makina. Theory and Methodology. New York: Elsevier Science Publishing Company, Inc., 1983. Chiras

Radiological Environmental Protection for PEP-II Ring High Luminosity Operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, James C.; Nakao, Noriaki; /SLAC

2006-08-16

Stanford Linear Accelerator Center (SLAC) is located in northern California, USA. Radiological environmental protection is one of the main elements of the radiation protection program. One of SLAC's accelerator facilities is B-Factory, whose PEP-II accelerator ring has been operating since 1997 and is being upgraded to higher luminosity operation. Four radiological issues associated with high luminosity operation up to CY2008 are re-evaluated: (1) annual doses in IR halls, (2) annual skyshine doses at site boundaries, (3) potential radioactive air releases, and (4) potential groundwater activation. This paper presents the skyshine doses and air emission doses to the Maximally Exposed Individualmore » (MEI) at SLAC site boundaries. The normal beam loss scenarios around PEP-II ring are presented first. In CY2008, the luminosity is 2 x 10{sup 34} cm{sup -2} s{sup -1}, and the stored current is 4.0-A for low-energy ring (LER ) and 2.2-A for high-energy ring (HER). The beam losses around PEP-II ring include those near injection region in IR10 and IR8 and those at collimators (e.g., HER collimators in IR12, LER collimators in IR4 and IR6). The beam losses in IR8 and IR10 (where injection into ring occurs) are further divided into septum, BAD (beam abort dump) and TD (tune-up dump), as well as apertures. The skyshine prompt dose rate distributions as a function of distance from an IR hall at four directions were calculated using the MARS15 Monte Carlo code. For skyshine dose to the MEI, the annual dose (7200 h/y occupancy) is calculated to be 2.9 mrem/y at Sand Hill Road (from e{sup -} losses in IR12 HER collimators) and 1.2 mrem/y at Horse Track Offices near IR6 (from e{sup +} losses in IR8, IR6 and IR4). These are lower than the SLAC skyshine limit of 5 mrem/y for any single facility within SLAC. Radionuclide productions in the air at the PEP-II IR10 were calculated using MARS15. Beam losses of 9-GeV electrons were assumed in three target cases: the copper TD, septum and BAD. Energy spectra of secondary particles of photons, neutrons, protons and pions in the IR10 air region were calculated. Radionuclide yields of {sup 11}C, {sup 13}N, {sup 15}O, {sup 3}H, {sup 7}Be and {sup 41}Ar were estimated using the obtained particle energy spectra, folded with the reaction cross sections. With certain operation and ventilation conditions, the annual air emission dose to the MEI at Sand Hill Road from e{sup -} losses in IR10 is calculated to be 0.004 mrem/y (7200 h/y occupancy). The annual dose to the MEI at Horse Track Offices is 0.002 mrem/y from e{sup +} losses in IR8, 0.003 mrem/y from IR6, and 0.025 mrem/y from IR4. The doses are dominated by {sup 13}N. Therefore, the EPA annual dose limit of 10 mrem/y for SLAC and the continuous ventilation monitoring limit of 0.1 mrem/y for each release point are not exceeded.« less

Effect of Dipole Perturbation on a Good Confining Surface Near X Point

NASA Astrophysics Data System (ADS)

Prakash, Sushant; Witmer, Lisa; Punjabi, Alkesh; Ali, Halima

2002-11-01

We analyze effects of dipole perturbation on a good magnetic surface of a single null divertor tokamak using the method of maps developed by Punjabi and Boozer /1/. Unperturbed fields are represented by the Symmetric Simple Map /2/. Effects of high MN perturbation are represented by the Dipole Map (DM) /2/ given by: x_n+1 = x_n+2δ s^3x_n[(y_n-y_s+s) / [x_n+1^2+(y_n-y_s+s)^2]^2], y_n+1 = y_n+δ s^3x_n[[(y_n-y_s+s)^2-x_n+1^2] / [x_n+1^2+(y_n-y_s+s)^2]^2] The good surface is x_0=0 and y_0=0.952873. We start with the strength of perturbation, δ=0, increase it slowly, and observe how the surface changes. The results will be presented. This project is supported by the QEM network NASA Sharp Plus program and by DE-FG02-02ER54673. The work is done on the FUSION1 server under Profs. Ali and Punjabi 1. Punjabi A., Verma A. and Boozer A., Phys. Rev. Lett., 69, 3322 (1992) 2. Ali H., Punjabi A. and Boozer A., Dipole Map for Single-null Divertor Tokamak, 2002 International Congress on Plasma Physics, Manly, Australia.

COPEing With Environmental Education Program Development and Infusion into the Global Studies Curricula of Rural Schools.

ERIC Educational Resources Information Center

Peters, Richard O.

An environmental education-oriented global studies program to promote attitudes of environmental stewardship can be implemented in K-12 rural school systems, as an integrated part of social studies instruction, without overburdening the curriculum, by using the Curriculum Organization and Program Evaluation (COPE) model. The model provides…

A Block-LU Update for Large-Scale Linear Programming

DTIC Science & Technology

1990-01-01

linear programming problems. Results are given from runs on the Cray Y -MP. 1. Introduction We wish to use the simplex method [Dan63] to solve the...standard linear program, minimize cTx subject to Ax = b 1< x <U, where A is an m by n matrix and c, x, 1, u, and b are of appropriate dimension. The simplex...the identity matrix. The basis is used to solve for the search direction y and the dual variables 7r in the following linear systems: Bky = aq (1.2) and

Remedial investigation work plan for Bear Creek Valley Operable Unit 2 (Rust Spoil Area, SY-200 Yard, Spoil Area 1) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-05-01

The enactment of the Resource Conservation and Recovery Act (RCRA) in 1976 and the Hazardous and Solid Waste Amendments (HSWA) to RCRA in 1984 created management requirements for hazardous waste facilities. The facilities within the Oak Ridge Reservation (ORR) were in the process of meeting the RCRA requirements when ORR was placed on the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) on November 21, 1989. Under RCRA, the actions typically follow the RCRA Facility Assessment (RFA)/RCRA Facility Investigation (RFI)/Corrective Measures Study (CMS)/Corrective Measures implementation process. Under CERCLA the actions follow the PA/SI/Remedial Investigation (RI)/Feasibility Studymore » (FS)/Remedial Design/Remedial Action process. The development of this document will incorporate requirements under both RCRA and CERCLA into an RI work plan for the characterization of Bear Creek Valley (BCV) Operable Unit (OU) 2.« less

Evaluation of Calendar Year 1997 Groundwater and Surface Water Quality Data For The Chestnut Ridge Hydrogeologic Regime At The U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, S.B.

1998-09-01

This report presents an evaluation of the groundwater monitoring data obtained in the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime) during calendar year (CY) 1997. The Chestnut Ridge Regime encompasses a section of Chestnut Ridge bordered by the U.S. Department of Energy (DOE) Y-12 Plant in Bear Creek Valley (BCV) to the north, Scarboro Road to the eas~ Bethel Valley Road to the south, and an unnamed drainage basin southwest of the Y-12 Plant (Figure 1). Groundwater quality monitoring is performed at hazardous and nonhazardous waste management facilities in the regime under the auspices of the Y-12 Plant Groundwater Protectionmore » Program (GWPP). The CY 1997 monitoring data are presented in Calendar Year 1997 Annual Groundwater Monitoring Report for the Chestnut Ridge Hydrogeolo~"c Regime at the US. Department of Energy Y-12 Plant, Oak Ridge, Tennessee (MA Technical Services, Inc. 1998), which also presents results of site-specific monitoring data evaluations required under the Resource Conservation and Recovery Act (RCIL4) post-closure permit (PCP) for the Chestnut Ridge Regime« less

40 CFR 191.12 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Definitions. 191.12 Section 191.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR MANAGEMENT AND DISPOSAL OF SPENT NUCLEAR FUEL, HIGH-LEVEL AND...

Research and Technology Development Activities to Address the DOE-EM Environmental Mercury Challenge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, Eric M; Peterson, Mark J

Human activities have altered trace metal distributions globally. This is especially true for the trace metal mercury (Hg), a pervasive global pollutant that can be methylated to form highly toxic methylmercury (MeHg), which bioaccumulates in aquatic food webs, endangering humans and other biota. Currently there are more than 3,000 mercury-contaminated sites identified worldwide and the United Nations Environment Programme has recently highlighted the risk of this contamination to human health [1, 2]. The Oak Ridge Reservation (ORR) represents an example of one of these mercury-contaminated sites. Unlike other contaminants metals, radionuclides, and organic solvents that impact the Department of Energymore » Office of Environmental Management (DOE-EM) cleanup program at the ORR and other DOE sites, mercury has several unique characteristics that make environmental remediation of the Y-12 National Security Complex one of the most formidable challenges ever encountered. These distinctive physicochemical properties for mercury include the following: it is a liquid at ambient temperature and pressure; it is the only metal that biomagnifies; and it is the only contaminant transported as a cation, as a dissolved or gaseous elemental metal (similar to an organic solvent), or as both a cation and a dissolved or gaseous elemental metal under environmental conditions. Because of these complexities, implementing cost effective and sustainable solutions that reduce mercury flux from various primary and secondary contamination sources will require linking basic science understanding and applied research advancements into Oak Ridge Office of Environmental Management s (OREM) cleanup process. Currently, DOE is investing in mercury-related research through a variety of programs, including the Office of Science sponsored Critical Interfaces Science Focus Area, EM headquarters sponsored Applied Field Research Initiative, OREM-sponsored Lower East Fork Poplar Creek (LEFPC) Mercury Technology Development Program, Small Business Innovative Research (SBIR), and EM s Minority Serving Institutions Partnership Program. Collectively, these multi-institutional and multidisciplinary programs are generating new tools, knowledge, and remediation approaches that will enable efficient cleanup of mercury contaminated systems locally and globally. In this talk we will highlight the progress made to date in addressing key knowledge gaps required to solve this watershed-scale conundrum.« less

2003 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

2007-05-23

Annual Illness and Injury Surveillance Program report for 2003 for Y-12. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

Environmental Education, Values for the Future: Curriculum, Population, Environmental Ethics, Environmental Decisions, Economics, Ecosystems, Energy, and Technology. Packet K-2.

ERIC Educational Resources Information Center

Illinois State Office of Education, Springfield.

This booklet is one of a series in environmental education for students in grades K-12. Scientific literacy, a major goal of the program, is divided into seven concept areas: Economics, Ecosystems, Energy, Technology, Population, Environmental Ethics, and Environmental Decisions. Each of these areas represents a separate unit in the program. An…

Environmental Education, Values for the Future: Curriculum, Population, Environmental Ethics, Environmental Decisions, Economics, Ecosystems, Energy, and Technology. Packet 3-5.

ERIC Educational Resources Information Center

Illinois State Office of Education, Springfield.

This booklet is one of a series in environmental education for students in grades K-12. Scientific literacy, a major goal of the program, is divided into seven concept areas: Economics, Ecosystems, Energy, Technology, Population, Environmental Ethics, and Environmental Decisions. Each of these areas represents a separate unit in the program. An…

Report on the biological monitoring program for Bear Creek at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee, 1989-1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinzman, R.L.; Beauchamp, J.J.; Cada, G.F.

1996-04-01

The Bear Creek Valley watershed drains the area surrounding several closed Oak Ridge Y-12 Plant waste disposal facilities. Past waste disposal practices in the Bear Creek Valley resulted in the contamination of Bear Creek and consequent ecological damage. Ecological monitoring by the Biological Monitoring and Abatement Program (BMAP) was initiated in the Bear Creek watershed in May 1984 and continues at present. Studies conducted during the first year provided a detailed characterization of the benthic invertebrate and fish communities in Bear Creek. The initial characterization was followed by a biological monitoring phase in which studies were conducted at reduced intensities.

40 CFR 72.12 - Administrative appeals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures for...

40 CFR 72.12 - Administrative appeals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures for...

40 CFR 72.12 - Administrative appeals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures for...

40 CFR 72.12 - Administrative appeals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures for...

40 CFR 72.12 - Administrative appeals.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures for...

40 CFR 12.140 - Employment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Employment. 12.140 Section 12.140... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.140 Employment. No... employment under any program or activity conducted by the agency. The definitions, requirements, and...

7 CFR 799.12 - Program termination.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 7 2013-01-01 2013-01-01 false Program termination. 799.12 Section 799.12 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... resulting environmental effects on the quality of the human environment. ...

7 CFR 799.12 - Program termination.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 7 2012-01-01 2012-01-01 false Program termination. 799.12 Section 799.12 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... resulting environmental effects on the quality of the human environment. ...

7 CFR 799.12 - Program termination.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 7 2014-01-01 2014-01-01 false Program termination. 799.12 Section 799.12 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... resulting environmental effects on the quality of the human environment. ...

7 CFR 799.12 - Program termination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false Program termination. 799.12 Section 799.12 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... resulting environmental effects on the quality of the human environment. ...

7 CFR 799.12 - Program termination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Program termination. 799.12 Section 799.12 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... resulting environmental effects on the quality of the human environment. ...

Report: Environmental Job Training Program Implemented Well, But Focus Needed on Possible Duplication With Other EPA Programs

EPA Pesticide Factsheets

Report #12-P-0843, September 21, 2012. EPA effectively established and adhered to competitive criteria that resulted in the selection of job training proposals that addressed the broad goals of the Environmental Job Training program.

Environmental Education and K-12 Student Outcomes: A Review and Analysis of Research

ERIC Educational Resources Information Center

Ardoin, Nicole M.; Bowers, Alison W.; Roth, Noelle Wyman; Holthuis, Nicole

2018-01-01

Many practitioners and researchers describe academic and environmental benefits of environmental education for kindergarten through twelfth grade (K-12) students. To consider the empirical underpinnings of those program descriptions, we systematically analyzed the peer-reviewed literature (1994-2013), focusing on outcomes of environmental…

40 CFR 197.12 - What definitions apply in subpart B?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false What definitions apply in subpart B? 197.12 Section 197.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS PUBLIC HEALTH AND ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA...

40 CFR 197.12 - What definitions apply in subpart B?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false What definitions apply in subpart B? 197.12 Section 197.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS PUBLIC HEALTH AND ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA...

40 CFR 197.12 - What definitions apply in subpart B?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false What definitions apply in subpart B? 197.12 Section 197.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS PUBLIC HEALTH AND ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA...

40 CFR 197.12 - What definitions apply in subpart B?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true What definitions apply in subpart B? 197.12 Section 197.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS PUBLIC HEALTH AND ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA...

40 CFR 197.12 - What definitions apply in subpart B?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false What definitions apply in subpart B? 197.12 Section 197.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS PUBLIC HEALTH AND ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA...

The Oak Ridge Refrigerant Management Program

NASA Technical Reports Server (NTRS)

Kevil, Thomas H.

1995-01-01

For many years, chlorofluorocarbons (CFC's) have been used by the Department of Energy's (DOE) Oak Ridge Y-12 Plant in air conditioning and process refrigeration systems. However, Title 6 of the Clean Air Act Amendments (CAAA) and Executive Order 12843 (Procurement Requirements and Policies for Federal Agencies for Ozone Depleting Substances) signed by President Clinton require, as policy, that all federal agencies maximize their use of safe, alternate refrigerants and minimize, where economically practical, the use of Class 1 refrigerants. Unfortunately, many government facilities and industrial plants have no plan or strategy in place to make this changeover, even though their air conditioning and process refrigeration equipment may not be sustainable after CFC production ends December 31, 1995. The Y-12 Plant in Oak Ridge, Tennessee, has taken an aggressive approach to complying with the CAAA and is working with private industry and other government agencies to solve tough manufacturing and application problems associated with CFC and hydrochlorofluorocarbon (HCFC) alternatives. Y-12 was the first DOE Defense Program (DP) facility to develop a long-range Stratospheric Ozone Protection Plan for refrigerant management for compliance with the CAAA. It was also the first DOE DP facility to complete detailed engineering studies on retrofitting and replacing all air conditioning and process refrigeration equipment to enable operation with alternate refrigerants. The management plan and engineering studies are models for use by other government agencies, manufacturing plants, and private industry. This presentation identifies some of the hidden pitfalls to be encountered in the accelerated phaseout schedule of CFC's and explains how to overcome and prevent these problems. In addition, it outlines the general issues that must be considered when addressing the phase-out of ozone depleting substances and gives some 'lessons learned' by Y-12 from its Refrigerant Management Program. Discussion topics include requirements for developing a refrigerant management plan and establishing priorities for cost-effective compliance with the CAAA, as well as ways in which employees can be empowered to develop a comprehensive refrigerant management plan. The result of this employee empowerment was a cooperative labor-management effort that is beneficial for Y-12, DOE, and the environment.

Y-12 Plant decontamination and decommissioning technology logic diagram for Building 9201-4. Volume 2: Technology logic diagram

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-09-01

The Y-12 Plant Decontamination and Decommissioning Technology Logic Diagram for Building 9201-4 (TLD) was developed to provide a decision-support tool that relates decontamination and decommissioning (D and D) problems at Bldg. 9201-4 to potential technologies that can remediate these problems. This TLD identifies the research, development, demonstration, testing, and evaluation needed for sufficient development of these technologies to allow for technology transfer and application to D and D and waste management (WM) activities. It is essential that follow-on engineering studies be conducted to build on the output of this project. These studies will begin by selecting the most promising technologiesmore » identified in the TLD and by finding an optimum mix of technologies that will provide a socially acceptable balance between cost and risk. The TLD consists of three fundamentally separate volumes: Vol. 1 (Technology Evaluation), Vol. 2 (Technology Logic Diagram), and Vol. 3 (Technology Evaluation Data Sheets). Volume 2 contains the logic linkages among environmental management goals, environmental problems, and the various technologies that have the potential to solve these problems. Volume 2 has been divided into five sections: Characterization, Decontamination, Dismantlement, Robotics/Automation, and Waste Management. Each section contains logical breakdowns of the Y-12 D and D problems by subject area and identifies technologies that can be reasonably applied to each D and D challenge.« less

Calendar years 1989 and 1990 monitoring well installation program Y-12 plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-10-01

This report documents the well-construction activities at the Y-12 Plant in Oak Ridge, Tennessee during 1989 and 1990. The well- construction program consisted of installing seventy-five monitoring wells. Geologists from ERCE (formally the Engineering, Design and Geosciences Group) and Martin Marietta Energy Systems (Energy Systems), supervised and documented well-construction activities and monitored for health and safety concerns. Sixty-seven monitoring wells were installed under the supervision of an ERCE geologist from March 1989 to September 1990. Beginning in September 1990, Energy Systems supervised drilling activities for eight monitoring wells, the last of which was completed in December 1990. 9 refs., 3more » figs., 2 tabs.« less

Remedial investigation work plan for the Upper East Fork Poplar Creek Characterization Area, Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-01

More than 200 contaminated sites created by past waste management practices have been identified at the Y-12 Plant. Many of the sites have been grouped into operable units based on priority and on investigative and remediation requirements. The Y-12 Plant is one of three major facilities on the ORR. The ORR contains both hazardous and mixed-waste sites that are subject to regulations promulgated under the Resource Conservation and Recovery Act of 1976 (RCRA) and the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986. Under RCRA guidelines andmore » requirements from the Tennessee Department of Environment and Conservation (TDEC), the Y-12 Plant initiated investigation and monitoring of various sites within its boundaries in the mid-1980s. The entire ORR was placed on the National Priorities List (NPL) of CERCLA sites in November 1989. Following CERCLA guidelines, sites under investigation require a remedial investigation (RI) to define the nature and extent of contamination, evaluate the risks to public health and the environment, and determine the goals for a feasibility study (FS) of potential remedial actions.« less

High Endoatmospheric Defense Interceptor (HEDI) Technology Testing Program Environmental Assessment

DTIC Science & Technology

1989-05-31

FICATION I DOWNGRADING SCHEDULE UNLIMITED 4. PERFORMING ORGANIZATION REPORT NUMBER( S ) S . MONITORING ORGANIZATION REPORT NUMBER( S ) 6a. NAME OF...Technology Testing Program Environmental Asessment (U’. 12. PERSONAL AUTHOR( S ) HEDI Environmental Assessment Team, Mr. Dru Barrineau, Chairman. 13a...was the application of assessment criteria to identify test activities deemed to present no S -1 potential for significant environmental consequences

Development and psychometric properties of the Y-PASS questionnaire to assess correlates of lunchtime and after-school physical activity in children

PubMed Central

2014-01-01

Background To frame interventions, it is useful to understand context- and time-specific correlates of children’s physical activity. To do this, we need accurate assessment of these correlates. There are currently no measures that assess correlates at all levels of the social ecological model, contain items that are specifically worded for the lunchtime and/or after-school time periods, and assess correlates that have been conceptualised and defined by children. The aim of this study was to develop and evaluate the psychometric properties of the lunchtime and after-school Youth Physical Activity Survey for Specific Settings (Y-PASS) questionnaires. Methods The Y-PASS questionnaire was administered to 264 South Australian children (146 boys, 118 girls; mean age = 11.7 ± 0.93 years). Factorial structure and internal consistency of the intrapersonal, sociocultural and physical environmental/policy lunchtime and after-school subscales were examined through an exploratory factor analysis. The test-retest reliability of the Y-PASS subscales was assessed over a one-week period on a subsample of children (lunchtime Y-PASS: n = 12 boys, 12 girls, mean age of 11.6 ± 0.8 years; after-school Y-PASS: n = 9 boys, 13 girls; mean age = 11.4 ± 0.9 years). Results For the lunchtime Y-PASS, three factors were identified under each of the intrapersonal, sociocultural and physical environmental/policy subscales. For the after-school Y-PASS, six factors were identified in the intrapersonal subscale, four factors in the sociocultural subscale and seven factors in the physical environmental/policy subscale. Following item reduction, all subscales demonstrated acceptable internal consistency (Cronbach alpha = 0.78 – 0.85), except for the lunchtime sociocultural subscale (Cronbach alpha = 0.55). The factors and items demonstrated fair to very high test-retest reliability (ICC = 0.26 – 0.93). Conclusion The preliminary reliability and factorial structure evidence suggests the Y-PASS correlate questionnaires are robust tools for measuring correlates of context-specific physical activity in children. The multi-dimensional factor structure provides justification for exploring physical activity correlates from a social ecological perspective and demonstrates the importance of developing items that are context specific. Further development and refinement of the Y-PASS questionnaires is recommended, including a confirmatory factor analysis and exploring the inclusion of additional items. PMID:24885601

Underground storage tank management plan, Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-09-01

The Underground Storage Tank (UST) Program at the Oak Ridge Y-12 Plant was established to locate UST systems at the facility and to ensure that all operating UST systems are free of leaks. UST systems have been removed or upgraded in accordance with Tennessee Department of Environment and Conservation (TDEC) regulations and guidance. With the closure of a significant portion of the USTs, the continuing mission of the UST Management Program is to manage the remaining active UST systems and continue corrective actions in a safe regulatory compliant manner. This Program outlines the compliance issues that must be addressed, reviewsmore » the current UST inventory and compliance approach, and presents the status and planned activities associated with each UST system. The UST Program provides guidance for implementing TDEC regulations and guidelines for petroleum UST systems. The plan is divided into three major sections: (1) regulatory requirements, (2) active UST sites, and (3) out-of-service UST sites. These sections describe in detail the applicable regulatory drivers, the UST sites addressed under the Program, and the procedures and guidance for compliance.« less

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

Installation Restoration Program. Phase II. Confirmation/Quantification. Stage 1 for Air Force Plant 6, Cobb County, Georgia. Volume 3.

DTIC Science & Technology

1985-08-09

and regulations. Additional hazard areas refer to non-regulated operations and/or practices that pose potential risks to human and environmental ...ORGANI1A’iON REPORT NUMPERASE IRP-IIa-AFP6 64 xAfi OF PEROING ORG IS ZArTON Śo 7a.AM OF MONITORING OAYIZAToN Environmental Science ’ aeedwabi.) U.S. Air...Force and Engineering, Inc ca ed AORESS Y. State, And ZIP C017) AOSS Approvetaoe pblic reease; P. Box ESE Occupational and Environmental Gainesville, FL

A Supplementary Program for Environmental Education, Social Studies, Grades 1 Through 12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in these 12 teacher's guides for grades 1-12 are lesson plans and ideas for integrating social studies and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following this, behavioral objectives and…

Analysis of Rotary Aircraft Alternatives for NATO SOF Organic Air Wing

DTIC Science & Technology

2012-06-01

analysis with an assumed program start in 2013 and an end in 2019 to determine the impact of short program duration on platform selection. D...FY12 GO\\ LR,~itl\\ l Sli LABOR H13 (J()VI R\\\\iFI\\TSE I AROR FY14 GOVLR\\\\iLI\\ I Sl:. LABOR H15 SI:.PO CSS FY II SII’O CSS FY 12 SEI’() CSS fY 13

Ground Truth Studies - A hands-on environmental science program for students, grades K-12

NASA Technical Reports Server (NTRS)

Katzenberger, John; Chappell, Charles R.

1992-01-01

The paper discusses the background and the objectives of the Ground Truth Studies (GTSs), an activity-based teaching program which integrates local environmental studies with global change topics, utilizing remotely sensed earth imagery. Special attention is given to the five key concepts around which the GTS programs are organized, the pilot program, the initial pilot study evaluation, and the GTS Handbook. The GTS Handbook contains a primer on global change and remote sensing, aerial and satellite images, student activities, glossary, and an appendix of reference material. Also described is a K-12 teacher training model. International participation in the program is to be initiated during the 1992-1993 school year.

Using an Experimental Approach to Improving the Selective Reenlistment Bonus Program

DTIC Science & Technology

2007-06-01

when establishing a reenlistment bonus. 12 Paul G. Keat and Philip K. Y. Young . Managerial Economics ...Journal of Labor Economics Vol. 6, No. 4, October 1988, 423-444. Keat , Paul G. and Philip K. Y. Young . Managerial Economics : Economic Tools for...alternative compensation methods, specifically auctions, signaling theory, and experimental economics ; and explains how an economic experiment might be

Isolation, structural analysis, and expression characteristics of the maize nuclear factor Y gene families.

PubMed

Zhang, Zhongbao; Li, Xianglong; Zhang, Chun; Zou, Huawen; Wu, Zhongyi

2016-09-16

NUCLEAR FACTOR-Y (NF-Y) has been shown to play an important role in growth, development, and response to environmental stress. A NF-Y complex, which consists of three subunits, NF-YA, NF-YB, and, NF-YC, binds to CCAAT sequences in a promoter to control the expression of target genes. Although NF-Y proteins have been reported in Arabidopsis and rice, a comprehensive and systematic analysis of ZmNF-Y genes has not yet been performed. To examine the functions of ZmNF-Y genes in this family, we isolated and characterized 50 ZmNF-Y (14 ZmNF-YA, 18 ZmNF-YB, and 18 ZmNF-YC) genes in an analysis of the maize genome. The 50 ZmNF-Y genes were distributed on all 10 maize chromosomes, and 12 paralogs were identified. Multiple alignments showed that maize ZmNF-Y family proteins had conserved regions and relatively variable N-terminal or C-terminal domains. The comparative syntenic map illustrated 40 paralogous NF-Y gene pairs among the 10 maize chromosomes. Microarray data showed that the ZmNF-Y genes had tissue-specific expression patterns in various maize developmental stages and in response to biotic and abiotic stresses. The results suggested that ZmNF-YB2, 4, 8, 10, 13, and 16 and ZmNF-YC6, 8, and 15 were induced, while ZmNF-YA1, 3, 4, 6, 7, 10, 12, and 13, ZmNF-YB15, and ZmNF-YC3 and 9 were suppressed by drought stress. ZmNF-YA3, ZmNF-YA8 and ZmNF-YA12 were upregulated after infection by the three pathogens, while ZmNF-YA1 and ZmNF-YB2 were suppressed. These results indicate that the ZmNF-Ys may have significant roles in the response to abiotic and biotic stresses. Copyright © 2016 Elsevier Inc. All rights reserved.

Proceedings for the Annual Army Environmental Research and Development Symposium (14th) Held in Williamsburg, Virginia on 14-16 November 1989

DTIC Science & Technology

1990-04-01

Lewandowski, Basil C. Baltzis, Lily Y. Young, Gene Carrazza, and Jose Yamoza ENVIRONMENTAL CONCERNS IN TESTING LIQUID GUN PROPELLANTS ........ 329...The range of contaminants in soil is now known to be very broad, including petroleum, heavy metals, dioxins, pesticides , organic solvents and others...PCBs/ pesticides by EPA Contract Laboratory Program procedures. The latter leachates also have been tested for acute and chronic toxicity to Ceriodaphnia

The world bank and the environment, exercise 1992. Annual report. Banco mundial y el medio ambiente, ejercicio de 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-01-01

The report describes the Bank's activities in assisting countries with environmental management, such as programs to reduce poverty without exhausting natural resources. Included are assessments of the environmental impacts of projects supported by World Bank loans, and accounts of efforts to meet global environmental challenges with coordinated international action through the Global Environment Facility (GEF). Among the events in the period covered by the report are the affirmation of the World Bank's participation with United Nations organizations in the GEF and the Bank's administration of pilot programs aimed at finding solutions to such global environmental problems as pollution of internationalmore » waters, global warming, depletion of the Earth's ozone layer, and dwindling biological diversity; the United Nations Conference on Environment and Development; and the publication of the World Development Report 1992, with its theme of development and the environment.« less

Probabilistic modeling of the flows and environmental risks of nano-silica.

PubMed

Wang, Yan; Kalinina, Anna; Sun, Tianyin; Nowack, Bernd

2016-03-01

Nano-silica, the engineered nanomaterial with one of the largest production volumes, has a wide range of applications in consumer products and industry. This study aimed to quantify the exposure of nano-silica to the environment and to assess its risk to surface waters. Concentrations were calculated for four environmental (air, soil, surface water, sediments) and two technical compartments (wastewater, solid waste) for the EU and Switzerland using probabilistic material flow modeling. The corresponding median concentration in surface water is predicted to be 0.12 μg/l in the EU (0.053-3.3 μg/l, 15/85% quantiles). The concentrations in sediments in the complete sedimentation scenario were found to be the largest among all environmental compartments, with a median annual increase of 0.43 mg/kg · y in the EU (0.19-12 mg/kg · y, 15/85% quantiles). Moreover, probabilistic species sensitivity distributions (PSSD) were computed and the risk of nano-silica in surface waters was quantified by comparing the predicted environmental concentration (PEC) with the predicted no-effect concentration (PNEC) distribution, which was derived from the cumulative PSSD. This assessment suggests that nano-silica currently poses no risk to aquatic organisms in surface waters. Further investigations are needed to assess the risk of nano-silica in other environmental compartments, which is currently not possible due to a lack of ecotoxicological data. Copyright © 2015 Elsevier B.V. All rights reserved.

Two Dimensional Linear Elastic Analysis of Fracture Specimens User’s Manual of a Finite Element Computer Program.

DTIC Science & Technology

1980-02-01

8 d. Data Set 4 8 e. Data Set 5 9 f. Data Set 6 9 g. Data Set 7 10 h. Data Set 8 10 i. Data Set 9 11 J. Data Set 10 12 k. Data...Coordinates NODE X Y NODE X Y NODE X Y 1 4.0 0.5 7 3.50 1.0 13 1.50 1.5 2 4.0 1.0 8 3.50 1.5 14 1.25 0.5 3 4.0 1.5 9 2.50 0.5 15 1.25 1.5 4 3.75 0.5 10 ...4 1+5 1+6 1+7 1 1 3 8 6 2 5 7 4 2 8 13 11 6 10 12 9 7 3 16 11 13 18 14 12 15 17 Note that I can be chosen to be any corner node. 6. PLOTTING THE

40 CFR 501.12 - Program description.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 501.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STATE... technical support, except where a State is seeking authorization for an established sewage sludge management... section, except where a State is seeking authorization for an established sewage sludge management program...

Post-Glacial and Paleo-Environmental History of the West Coast of Vancouver Island

NASA Astrophysics Data System (ADS)

Dallimore, A.; Enkin, R. J.

2005-12-01

Annually laminated sediments in anoxic fjords are potentially ideal paleoclimate recorders, particularly once proxy measurements for atmospheric, oceanographic and sedimentological conditions have been calibrated. On the west coast of Canada, these sediments also record the changing environment as glaciers retreated from this area about 12 ka y BP. In Effingham Inlet, a 40 m core taken from the French ship the Marion Dufresne as part of the international IMAGES/PAGES program, gives evidence of an isolation basin at maximum glacial isostatic rebound and lowest paleo-sea level followed by eustatic sea level rise about 10 ka y BP. The Late Pleistocene record also marks dramatic changes in glacial sedimentary source and transport. Excellent chronological control is provided by complementary yet independent dating methods including radiocarbon dates on both plants and shells, identification of the Mazama Ash, varve counting and paleomagnetic, paleosecular variation correlations in the lower, pro-glacial section of the core which does not contain organic material. Paleoenvironmental evidence from this core provides information on immediate post-glacial conditions along the coast and rapid climatic changes throughout the Holocene, with implications for the possibility of early human migration routes and refugia.

INTRODUCTION: 26th EGAS Conference of the European Group for Atomic Spectroscopy

NASA Astrophysics Data System (ADS)

Corbalán, R.; Orriols, G.; Pi, F.

1995-01-01

The 26th conference of EGAS, the European Group for Atomic Spectroscopy, was held in Bellaterra (Barcelona), Spain, 12-15 July 1994. The conference was hosted by the Departament de Física, Universitat Autònoma de Barcelona, and brought together 216 participants from 29 countries. The program comprised 14 survey lectures by invited speakers and 230 contributed papers (45 oral and 185 posters). Applications of atomic spectroscopy are taking an increasingly important place in the EGAS conferences. This year a Symposium on Spectroscopy for Environmental Analysis was held during the meeting. Six of the survey lectures were presented at this Symposium. Thirteen of the invited lectures have been prepared for publication by the authors and are gathered in the present issue of Physica Scripta. The conference organizers thank all sponsors, especially the Spanish Direccción General de Investigación Científica y Técnica (DGICYT) and the Comisión Interministerial de Ciencia y Tecnología (CICYT), the Direcció General de Recerca (DGR) of the Generalitat de Catalunya, the Fundació Catalana per la Recerca, the Universitat Politècnica de Catalunya and the International Science Foundation (ISF), for supporting the 26th EGAS meeting.

7 CFR 1779.9 - Environmental requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Environmental requirements. 1779.9 Section 1779.9... AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.9 Environmental requirements. Facilities financed must undergo an environmental impact analysis in accordance with the National...

Effects of a 12-week Tai Chi Chuan program versus a balance training program on postural control and walking ability in older people.

PubMed

Lelard, Thierry; Doutrellot, Pierre-Louis; David, Pascal; Ahmaidi, Said

2010-01-01

Lelard T, Doutrellot P-L, David P, Ahmaidi S. Effects of a 12-week Tai Chi Chuan program versus a balance training program on postural control and walking ability in older people. To compare the respective effects of 2 balance training programs: a Tai Chi (TC) program and a balance training program on static postural control and walking ability. Randomized controlled trial. General community. Older subjects (N=28) participated in the study. The TC group (n=14; mean age +/- SD, 76.8+/-5.1y) and the balance training group (n=14; 77.0+/-4.5y) were both trained for 12 weeks. Static postural control was assessed via measurement of center of pressure sway under eyes open (EO) and eyes closed (EC) conditions. Walking speed over a 10-meter course was also assessed. After the 12-week training period, there were no significant differences in walking speed or postural parameters in either the EO or EC conditions for the TC and balance training groups. Performance in the EC condition was lower than in the EO condition in pretest and posttest for the balance training and TC groups. The Romberg quotient (EO/EC ratio) was significantly higher after the balance training program than the TC program (P<.05). We cannot conclude that the balance training program has better effects than the TC program on postural control or walking ability. None of the outcome measures showed significant change posttraining in either the TC or the balance training groups. However, the differences described in the Romberg quotient after the training period between the TC and the balance training groups suggest that TC should be helpful to limit the deleterious effects of eye closure on postural balance. Copyright (c) 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Education and the Consolidation of Democracy in Latin America: Innovations To Provide Quality Basic Education with Equity. Advocacy Series Education and Development 4.

ERIC Educational Resources Information Center

Reimers, Fernando

Three case studies show innovative education programs that provide quality basic education with equity. After explaining the significance of educational innovation of democracy in Latin America and the constraints to educational development, the investigation of the three programs follows. The program of Fe y Alegria (Faith and Joy) in 12…

Neighborhood Environment Walkability Scale for Youth (NEWS-Y): reliability and relationship with physical activity.

PubMed

Rosenberg, Dori; Ding, Ding; Sallis, James F; Kerr, Jacqueline; Norman, Gregory J; Durant, Nefertiti; Harris, Sion K; Saelens, Brian E

2009-01-01

To examine the psychometric properties of the Neighborhood Environment Walkability Scale-Youth (NEWS-Y) and explore its associations with context-specific and overall physical activity (PA) among youth. In 2005, parents of children ages 5-11 (n=116), parents of adolescents ages 12-18 (n=171), and adolescents ages 12-18 (n=171) from Boston, Cincinnati, and San Diego, completed NEWS-Y surveys regarding perceived land use mix-diversity, recreation facility availability, pedestrian/automobile traffic safety, crime safety, aesthetics, walking/cycling facilities, street connectivity, land use mix-access, and residential density. A standardized neighborhood environment score was derived. Self-reported activity in the street and in parks, and walking to parks, shops, school, and overall physical activity were assessed. The NEWS-Y subscales had acceptable test-retest reliability (ICC range .56-.87). Being active in a park, walking to a park, walking to shops, and walking to school were related to multiple environmental attributes in all three participant groups. Total neighborhood environment, recreation facilities, walking and cycling facilities, and land use mix-access had the most consistent relationships with specific types of activity. The NEWS-Y has acceptable reliability and subscales were significantly correlated with specific types of youth PA. The NEWS-Y can be used to examine neighborhood environment correlates of youth PA.

ENVIRONMENTAL MONITORING AND ASSESSMENT PROGRAM (EMAP): WESTERN STREAMS AND RIVERS STATISTICAL SUMMARY

EPA Science Inventory

This statistical summary reports data from the Environmental Monitoring and Assessment Program (EMAP) Western Pilot (EMAP-W). EMAP-W was a sample survey (or probability survey, often simply called 'random') of streams and rivers in 12 states of the western U.S. (Arizona, Californ...

A Supplementary Program for Environmental Education, Art, Grade 10-12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 10-12 are lesson plans and ideas for integrating art (drawing, painting, graphics, photography, and commercial art) and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem…

A Supplementary Program for Environmental Education, Mathematics, Grade 10-12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 10-12 are lesson plans and ideas for integrating mathematics and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following this, behavioral objectives and…

A Supplementary Program for Environmental Education, Business Education, Grade 9-12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 9-12 are lesson plans and ideas for integrating business education (general business, typing, shorthand, clerical and secretarial practice, and bookkeeping) and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its…

Environmental Impact Analysis Process. Environmental Impact Statement Space Shuttle Program Vandenberg AFB, California

DTIC Science & Technology

1978-01-01

Coastal Commission University of California, Irvine 1540 Market Street Department of Ecology and Evolutionary San Francisco, CA 94102 Biology FROM...Category... 4-5 4.2-3 North County I3ffbase Land Requirements for Projected Development to 1990 ............... 4-ti ..-1 Special Interest Plants to be...c•iacb•ii, and concrete batch plants . CONSTRULiCTIdh Je•v-. *1p rotitttr•,y 1.4 x 116 si ft hb 0I-ich thick Istisii rlIouy or?,’ ifaIt Ant ntilltd

Improved Understanding of Fenton-like Reactions for the In Situ Remediation of Contaminated Groundwater Including Treatment of Sorbed Contaminants and Destruction of DNAPLs

DTIC Science & Technology

2006-04-29

Dehalogenation of Chlorinated Methanes by Iron Metal.” Environ . Sci. Technol. 28, 2045-2053. McBride, M.B. Environmental Chemistry of Soils; Oxford Press: New...Oxidative Transformation of Triclosan and Chlorophene by Manganese Oxides. Environ . Sci. Technol. 2003, 37, 2421-2430 Zhang, Y., Crittenden, J.C...prepared under contract to the Department of Defense Strategic Environmental Research and Development Program (SERDP). The publication of this report does

40 CFR 12.103 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... more major life activities. (4) Is regarded as having an impairment means— (i) Has a physical or mental... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.103 Definitions. For... an equal opportunity to participate in, and enjoy the benefits of, programs or activities conducted...

Cleaning without chlorinated solvents

NASA Technical Reports Server (NTRS)

Thompson, L. M.; Simandl, R. F.

1995-01-01

Because of health and environmental concerns, many regulations have been passed in recent years regarding the use of chlorinated solvents. The Oak Ridge Y-12 Plant has had an active program to find alternatives for these solvents used in cleaning applications for the past 7 years. During this time frame, the quantity of solvents purchased has been reduced by 92 percent. The program has been a twofold effort. Vapor degreasers used in batch cleaning operations have been replaced by ultrasonic cleaning with aqueous detergent, and other organic solvents have been identified for use in hand-wiping or specialty operations. In order to qualify these alternatives for use, experimentation was conducted on cleaning ability as well as effects on subsequent operations such as welding, painting, and bonding. Cleaning ability was determined using techniques such as x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) which are capable of examining monolayer levels of contamination on a surface. Solvents have been identified for removal of rust preventative oils, lapping oils, machining coolants, lubricants, greases, and mold releases. Solvents have also been evaluated for cleaning urethane foam spray guns, swelling of urethanes, and swelling of epoxies.

40 CFR 141.12 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false [Reserved] 141.12 Section 141.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Maximum Contaminant Levels § 141.12 [Reserved] ...

7 CFR 1782.9 - Environmental requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Environmental requirements. 1782.9 Section 1782.9... AGRICULTURE (CONTINUED) SERVICING OF WATER AND WASTE PROGRAMS § 1782.9 Environmental requirements. Servicing... 1794 as required in § 1794.3. The appropriate environmental review will be completed prior to approval...

Integrating Environmental Management of Asthma into Pediatric Health Care: What Worked and What Still Needs Improvement?

PubMed

Roberts, James R; Newman, Nicholas; McCurdy, Leyla E; Chang, Jane S; Salas, Mauro A; Eskridge, Bernard; De Ybarrondo, Lisa; Sandel, Megan; Mazur, Lynnette; Karr, Catherine J

2016-12-01

The National Environmental Education Foundation (NEEF) launched an initiative in 2005 to integrate environmental management of asthma into pediatric health care. This study, a follow-up to a 2013 study, evaluated the program's impact and assessed training results by 5 new faculty champions. We surveyed attendees at training sessions to measure knowledge and the likelihood of asking about and managing environmental triggers of asthma. To conduct the program evaluation, a workshop was held with the faculty champions and NEEF staff in which we identified major program benefits, as well as challenges and suggestions for the future. Trainee baseline knowledge of environmental triggers was low, but they reported robust improvement in environmental triggers knowledge and intention to recommend environmental management. The program has a broad, national scope, reaching more than 12 000 physicians, health care providers, and students, and some faculty champions successfully integrated materials into health record. Program barriers and future endeavors were identified.

Water table in Long Island, New York, March 1971

USGS Publications Warehouse

Koszalka, Edward J.; Koch, Ellis

1971-01-01

The geologic framework and the hydrologic situation in Long Island are periodically reviewed by the U.S. Geological Survey as new knowledge is obtained from current investigations. This work is done through cooperative programs with Nassau and Suffolk County agencies and the New York State Department of Environmental Conservation. A unique opportunity to update many of the hydrogeologic maps occurred when the Geological Survey's Mineola, N.Y., office participated in the New England River Basins Commission's "Long Island Sound Study." This map, one of a series of open-file maps showing the updated information, was compiled from data obtained from G. E. Kimmel (written commun., July 1972) and Jensen and Soren (in press). Comparison of the March 1971 data with similar data for March 1970 (Kimmel, 1970) shows virtually no change in water levels on Long Island during the 12 month period, except for a slight decline in levels in central Suffolk County.

Mixed-Integer Nonconvex Quadratic Optimization Relaxations and Performance Analysis

DTIC Science & Technology

2016-10-11

Analysis of Interior Point Algorithms for Non-Lipschitz and Nonconvex Minimization,” (W. Bian, X. Chen, and Ye), Math Programming, 149 (2015) 301-327...Chen, Ge, Wang, Ye), Math Programming, 143 (1-2) (2014) 371-383. This paper resolved an important open question in cardinality constrained...Statistical Performance, and Algorithmic Theory for Local Solutions,” (H. Liu, T. Yao, R. Li, Y. Ye) manuscript, 2nd revision in Math Programming

A Survey of Environmental Education in Hamilton County Schools (K-12).

ERIC Educational Resources Information Center

Garver, Janice B.

Environmental education (EE) courses and programs offered in grades K-12 in Hamilton County (Ohio) public, private, and parochial schools were surveyed by means of a questionnaire mailed to 67 district level administrators, principals, and teachers. Questionnaires were returned from 5 private, 4 parochial, and 27 public schools, representing a 57…

A Supplementary Program for Environmental Education, Industrial Arts, Grade 9-12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 7-12 are lessons plans and ideas for integrating industrial arts (power mechanics, graphic arts, plastics, and electricity/electronics) and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area,…

A Supplementary Program for Environmental Education, Language Arts, Grades K Through 12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in these 13 teacher's guides for grades K-12 are lesson plans and ideas for integrating language arts and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following this, behavioral objectives and…

A Supplementary Program for Environmental Education, Industrial Arts, Grade 7-12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 7-12 are lesson plans and ideas for integrating industrial arts (drafting, woodworking, and metals) and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following…

A Supplementary Program for Environmental Education, Science, Grades K Through 12.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in these 13 teacher's guides for grades K-12 are lesson plans and ideas for integrating science and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following this, behavioral objectives and…

PEYA Winners

EPA Pesticide Factsheets

The President's Environmental Youth Award is a recognition program for K-12 students who conduct an environmental stewardship and community service project. One winner or group is recognized from each of EPA's 10 regions.

GENETIC AND ENVIRONMENTAL EFFECTS ON BODY MASS INDEX DURING ADOLESCENCE: A PROSPECTIVE STUDY AMONG FINNISH TWINS

PubMed Central

Lajunen, Hanna-Reetta; Kaprio, Jaakko; Keski-Rahkonen, Anna; Rose, Richard J.; Pulkkinen, Lea; Rissanen, Aila; Silventoinen, Karri

2009-01-01

Objective To study genetic and environmental factors affecting body mass index (BMI) and BMI phenotypic correlations across adolescence. Design Prospective, population-based, twin cohort study. Subjects and methods We used twin modeling in 2413 monozygotic and same-sex and opposite-sex dizygotic Finnish twin pairs born in 1983–1987 and assessed by self-report questionnaires at 11–12, 14, and 17 years. Results Heritability of BMI was estimated to be 0.58–0.69 among 11–12- and 14-year-old boys and girls, 0.83 among 17-year-old boys and 0.74 among girls. Common environmental effects shared by siblings were 0.15–0.24 among 11–12- and 14-year-old boys and girls but no longer discernible at 17 y. Unique environmental effects were 0.15–0.23. Additive genetic factors explained 90–96% of the BMI phenotypic correlations across adolescence, whereas unique environmental factors explained the rest. Common environment had no effect on BMI phenotypic correlations. Conclusions The genetic contribution to BMI is strong during adolescence, and it mainly explains BMI phenotypic correlations across adolescence. Common environmental factors have an effect on BMI during early adolescence, but that effect disappears by late adolescence. PMID:19337205

Recycled Uranium Mass Balance Project Y-12 National Security Complex Site Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2000-12-01

This report has been prepared to summarize the findings of the Y-12 National Security Complex (Y-12 Complex) Mass Balance Project and to support preparation of associated U. S. Department of Energy (DOE) site reports. The project was conducted in support of DOE efforts to assess the potential for health and environmental issues resulting from the presence of transuranic (TRU) elements and fission products in recycled uranium (RU) processed by DOE and its predecessor agencies. The United States government used uranium in fission reactors to produce plutonium and tritium for nuclear weapons production. Because uranium was considered scarce relative to demandmore » when these operations began almost 50 years ago, the spent fuel from U.S. fission reactors was processed to recover uranium for recycling. The estimated mass balance for highly enriched RU, which is of most concern for worker exposure and is the primary focus of this project, is summarized in a table. A discrepancy in the mass balance between receipts and shipments (plus inventory and waste) reflects an inability to precisely distinguish between RU and non-RU shipments and receipts involving the Y-12 Complex and Savannah River. Shipments of fresh fuel (non-RU) and sweetener (also non-RU) were made from the Y-12 Complex to Savannah River along with RU shipments. The only way to distinguish between these RU and non-RU streams using available records is by enrichment level. Shipments of {le}90% enrichment were assumed to be RU. Shipments of >90% enrichment were assumed to be non-RU fresh fuel or sweetener. This methodology using enrichment level to distinguish between RU and non-RU results in good estimates of RU flows that are reasonably consistent with Savannah River estimates. Although this is the best available means of distinguishing RU streams, this method does leave a difference of approximately 17.3 MTU between receipts and shipments. Slightly depleted RU streams received by the Y-12 Complex from ORGDP and PGDP are believed to have been returned to the shipping site or disposed of as waste on the Oak Ridge Reservation. No evidence of Y-12 Complex processing of this material was identified in the historical records reviewed by the Project Team.« less

Agility and change of direction in soccer: differences according to the player ages.

PubMed

Fiorilli, Giovanni; Mitrotasios, Michalis; Iuliano, Enzo; Pistone, Eugenio M; Aquino, Giovanna; Calcagno, Giuseppe; DI Cagno, Alessandra

2017-12-01

The goal of this study was to compare the changes of direction speed (CODS) and reactive agility (RA) in soccer players of different ages, in order to optimize the best training of these skills. One hundred eighty-seven players, divided into bi-annual age-groups, U12, U14, U16 and U18, performed two tests: Y-Agility Test, carried out in planned and reactive mode (Y-PLAN and Y-REAC) and Illinois for Change of Direction Test (ICODT). Difference between Y-REAC minus Y-PLAN represents the index of reactivity (REAC-INDEX). MANOVA showed significant differences among groups (F3,182=14.591; P<0.01; η2p=0.244). Y-PLAN showed significant differences only between U12 and the other groups (P<0.01). ICODT results were significantly different between the groups U12 and U14 and the other groups (P<0.01). Significant Pearson's correlations between Y-TEST and ICODT, for the three categories of young players (0.398 P<0.05; 0.615 P<0.01; 0.608 P<0.01 respectively), were found, whereas no significant correlation was found in U18 group. The best performance of Y-PLAN and ICODT, through age, depends on physical skill level, whereas the best RA results depend on technique and experience that help the players to use anticipatory skill. The high correlations between CODS and RA performances, differently than adult athletes, suggest that an effective work program for young players may include RA and CODS training at the same time.

Oak Ridge Environmental Information System (ORIES) site workstation information packet for OREIS V1.2. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voorhees, L.D.; McCord, R.A.; Durfee, R.C.

1993-02-01

The OREIS site workstation information packet was developed to accompany the OREIS site workstations, which are being delivered to the Environmental Restoration programs at the five DOE-OR sites. The packet is written specifically for the Site ER program staff at each of the five Sites who have been designated the OREIS contact by their ER program manager, and is not intended for general distribution. The packet provides an overview of the components of OREIS, points to more detailed information provided in the accompanying vendor and OREIS developed manuals, and includes information on training opportunities and user support.

School-Based Obesity Prevention Interventions for Chilean Children During the Past Decades: Lessons Learned12

PubMed Central

Kain, Juliana; Uauy, Ricardo; Concha, Fernando; Leyton, Bárbara; Bustos, Nelly; Salazar, Gabriela; Lobos, Luz; Vio, Fernando

2012-01-01

Obesity in Chilean children has increased markedly over the past decades. School-based obesity prevention interventions have been launched by the Ministry of Health and academic groups to tackle this condition. We summarize the main characteristics of the interventions that we have conducted and reflect on the lessons learned. Since 2002, we conducted 1 pilot study, a 2-y controlled intervention including 6- to 12–y-old children (Casablanca), another pilot study, and a 2-y controlled intervention including teachers and their 4- to 9–y-old students (Macul). Both interventions consisted of training teachers to deliver contents on healthy eating, increasing physical education classes, and, additionally in Macul, teachers participated in a wellness program. BMI Z-score and obesity prevalence were compared among children in intervention and control schools by year and among students of intervention and control teachers. In the Casablanca study, the impact was greatest on the younger children during the first school year when the study received the full funding that was required. In Macul, although intervention teachers exhibited improvements in anthropometry and blood measures, the impact on the children was not related to their results. The main lessons learned from these experiences are random allocation of schools, although methodologically desirable, is not always possible; participation of parents is very limited; obesity is not recognized as a problem; and increasing physical activity and implementing training programs for teachers is difficult due to an inflexible curriculum and lack of teachers’ time. Unless these barriers are overcome, obesity prevention programs will not produce positive and lasting outcomes. PMID:22798002

Environmental Project Provides Work Experience for Rural Youth

ERIC Educational Resources Information Center

Meier, Amy L.; Smith, Marilyn; Usinger, Janet

2010-01-01

Bootstraps is a 12-week program designed for rural youth, ages 18-21, who are not working and not in school. The program goal is for participants to develop skills and motivation to find meaningful work, which is accomplished through a combination of classroom learning and practical fieldwork. The environmental fieldwork on public lands, funded by…

Environmental Impact From Accelerator Operation at SLAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, James C

1999-03-22

Environmental impacts from electron accelerator operations at the Stanford Linear Accelerator Center, which is located near populated areas, are illustrated by using examples of three different accelerator facilities: the low power (a few watts) SSRL, the high power (a few kilowatts) PEP-II, and the 50-kW SLC. Three types of major impacts are discussed: (1) off-site doses from skyshine radiation, mainly neutrons, (2) off-site doses from radioactive air emission, mainly {sup 13}N, and (3) radioactivities, mainly {sup 3}H, produced in the groundwater. It was found that, from SSRL operation, the skyshine radiation result in a MEI (Maximum Exposed Individual) of 0.3more » {mu}Sv/y while a conservative calculation using CAP88 showed a MEI of 0.36 {mu}Sv/y from radioactive air releases. The calculated MEI doses due to future PEP-II operation are 30 {mu}Sv/y from skyshine radiation and 2 {mu}Sv/y from air releases. The population doses due to radioactive air emission are 0.5 person-mSv from SSRL and 12 person-mSv from PEP-II. Because of the stronger decrease of skyshine dose as the distance increases, the population dose from skyshine radiation are smaller than that from air release. The third environmental impact, tritium activity produced in the groundwater, was also demonstrated to be acceptable from both the well water measurements and the FLUKA calculations for the worst case of the SLC high-power dump.« less

76 FR 12103 - Notice of Availability of the Final Site-Wide Environmental Impact Statement for the Y-12...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

... comparison), and addresses public comments received on the Draft SWEIS and the Wetlands Assessment related to... operations. Alternative 4: Under the Capability-sized UPF Alternative, NNSA would build a smaller UPF... Production/Capability-sized UPF Alternative, NNSA would build a smaller UPF (approximately 350,000 sq. ft...

Environmental Survey Report for the ETTP: Environmental Management Waste Management Facility (EMWMF) Haul Road Corridor, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, M.J.

2005-12-20

This report summarizes the results of environmental surveys conducted within the corridor of a temporary haul road (''Haul Road'') to be constructed from East Tennessee Technology Park (ETTP) to the Environmental Management Waste Management Facility (EMWMF) located just west of the Y-12 National Security Complex (Y-12). Environmental surveys were conducted by natural resource experts at Oak Ridge National Laboratory who routinely assess the significance of various project activities on the Oak Ridge Reservation (ORR). ORNL assistance to the Haul Road Project included environmental assessments necessary to determine the best route for minimizing impacts to sensitive resources such as wetlands ormore » rare plants. Once the final route was chosen, environmental surveys were conducted within the corridor to evaluate the impacts to sensitive resources that could not be avoided. The final Haul Road route follows established roads and a power-line corridor to the extent possible (Fig. 1). Detailed explanation regarding the purpose of the Haul Road and the regulatory context associated with its construction is provided in at least two major documents and consequently is not presented here: (1) Explanation of Significant Differences for the Record of Decision for the Disposal of Oak Ridge Reservation Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Waste, Oak Ridge, Tennessee (January 2005, DOE/OR/01-2194&D2), and (2) Environmental Monitoring Plan for The ETTP to EMWMF Haul Road for the Disposal of Oak Ridge Reservation Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Waste, Oak Ridge, Tennessee (April 2005, BJC/OR-2152). The focus of this report is a description of the sensitive resources to be impacted by Haul Road construction. Following a short description of the methods used for the environmental surveys, results and observations are presented in the following subsections: (1) General description of the affected environment; (2) Rare plants and vegetation assemblages; (3) Rare wildlife and their habitat; (4) Rare aquatic species; and (5) Wetlands/Floodplains. A summary of project actions taken or planned in order to avoid, minimize, or mitigate the environmental impacts associated with this project are summarized in the conclusion section of this report.« less

40 CFR 12.160 - Communications.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Communications. 12.160 Section 12.160... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication with applicants...

40 CFR 12.160 - Communications.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Communications. 12.160 Section 12.160... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication with applicants...

40 CFR 12.160 - Communications.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Communications. 12.160 Section 12.160... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication with applicants...

Environmental Design: Instructional Guide and Resource for Elementary and Secondary School Use.

ERIC Educational Resources Information Center

Montgomery County Public Schools, Rockville, MD.

Instructional units with suggested resources and appropriate activities for teaching environmental design to students in grades 6-12 are presented. An overview of program goals and suggested environmental awareness exercises and projects is followed by six illustrative units. The first unit (grade 6) focuses on environmental awareness and…

Changes in Social Capital and Networks: A Study of Community-Based Environmental Management Through a School-Centered Research Program

NASA Astrophysics Data System (ADS)

Thornton, Teresa; Leahy, Jessica

2012-02-01

Social network analysis (SNA) is a social science research tool that has not been applied to educational programs. This analysis is critical to documenting the changes in social capital and networks that result from community based K-12 educational collaborations. We review SNA and show an application of this technique in a school-centered, community based environmental monitoring research (CBEMR) program. This CBEMR employs K-12 students, state and local government employees, environmental organization representatives, local businesses, colleges, and community volunteers. As citizen scientists and researchers, collaborators create a database of local groundwater quality to use as a baseline for long-term environmental health management and public education. Past studies have evaluated the reliability of data generated by students acting as scientists, but there have been few studies relating to power dynamics, social capital, and resilience in school-centered CBEMR programs. We use qualitative and quantitative data gathered from a science education program conducted in five states in the northeastern United States. SPSS and NVivo data were derived from semi-structured interviews with thirty-nine participants before and after their participation in the CBEMR. Pajek software was used to determine participant centralities and power brokers within networks. Results indicate that there were statistically significant increases in social capital and resilience in social networks after participation in the school-centered CBEMR program leading to an increased community involvement in environmental health management. Limiting factors to the CBMER were based on the educator/administration relationship.

Incidence and Mortality Rates and Clinical Characteristics of Type 1 Diabetes among Children and Young Adults in Cochabamba, Bolivia.

PubMed

Duarte Gómez, Elizabeth; Gregory, Gabriel Andrew; Castrati Nostas, Miriam; Middlehurst, Angela Christine; Jenkins, Alicia Josephine; Ogle, Graham David

2017-01-01

To determine incidence, mortality, and clinical status of youth with diabetes at the Centro Vivir con Diabetes, Cochabamba, Bolivia, with support from International Diabetes Federation Life for a Child Program. Incidence/mortality data analysis of all cases (<25 year (y)) diagnosed January 2005-February 2017 and cross-sectional data (December 2015). Over 12.2 years, 144 cases with type 1 diabetes (T1D) were diagnosed; 43.1% were male. Diagnosis age was 0.3-22.2 y; peak was 11-12 y. 11.1% were <5 y; 29.2%, 5-<10 y; 43.1%, 10-<15 y; 13.2%, 15-<20 y; and 3.5%, 20-<25 y. The youngest is being investigated for monogenic diabetes. Measured incidence in Cercado Province (Cochabamba Department) was 2.2/100,000 children < 15 y/y, with ≈80% ascertainment, giving total incidence of 2.7/100,000 children < 15 y/y. Two had died. Crude mortality rate was 2.3/1000 patient years. Clinical data on 141 cases <35 y: mean/median HbA1c was 8.5/8.2% (69/62 mmol/mol), levels higher in adolescents. Three were on renal replacement therapy; four others had substantial renal impairment. Elevated BMI, triglycerides, and cholesterol were common: 19.1%, 18.3%, and 39.1%, respectively. Bolivia has low T1D incidence. Reasonable glycemic control is being achieved despite limited resources; however, some have serious complications and adverse cardiovascular risk factor profiles. Further attention is needed for complications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, Joan F.

The US Department of Energy’s (DOE’s) Oak Ridge Reservation (ORR) is located in Roane and Anderson counties in East Tennessee, about 40 km (25 miles) from Knoxville. ORR is one of DOE’s most unique and complex sites. It encompasses three major facilities and thousands of employees that perform every mission in the DOE portfolio—energy research, environmental restoration, national security, nuclear fuel supply, reindustrialization, science education, basic and applied research in areas important to US security, and technology transfer. ORR was established in the early 1940s as part of the Manhattan Project for the purposes of enriching uranium and pioneering methodsmore » for producing and separating plutonium. Today, scientists at the Oak Ridge National Laboratory (ORNL), DOE’s largest multipurpose national laboratory, conduct world-leading research in advanced materials, alternative fuels, climate change, and supercomputing. The Y-12 National Security Complex (Y-12 or Y-12 Complex) is vital to maintaining the safety, security, and effectiveness of the US nuclear weapons stockpile and reducing the global threat posed by nuclear proliferation and terrorism. The East Tennessee Technology Park (ETTP), a former uranium enrichment complex, is being transitioned to a clean, revitalized industrial park.« less

Isolation, structural analysis, and expression characteristics of the maize nuclear factor Y gene families

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Zhongbao; Li, Xianglong; Zhang, Chun

NUCLEAR FACTOR-Y (NF-Y) has been shown to play an important role in growth, development, and response to environmental stress. A NF-Y complex, which consists of three subunits, NF-YA, NF-YB, and, NF-YC, binds to CCAAT sequences in a promoter to control the expression of target genes. Although NF-Y proteins have been reported in Arabidopsis and rice, a comprehensive and systematic analysis of ZmNF-Y genes has not yet been performed. To examine the functions of ZmNF-Y genes in this family, we isolated and characterized 50 ZmNF-Y (14 ZmNF-YA, 18 ZmNF-YB, and 18 ZmNF-YC) genes in an analysis of the maize genome. Themore » 50 ZmNF-Y genes were distributed on all 10 maize chromosomes, and 12 paralogs were identified. Multiple alignments showed that maize ZmNF-Y family proteins had conserved regions and relatively variable N-terminal or C-terminal domains. The comparative syntenic map illustrated 40 paralogous NF-Y gene pairs among the 10 maize chromosomes. Microarray data showed that the ZmNF-Y genes had tissue-specific expression patterns in various maize developmental stages and in response to biotic and abiotic stresses. The results suggested that ZmNF-YB2, 4, 8, 10, 13, and 16 and ZmNF-YC6, 8, and 15 were induced, while ZmNF-YA1, 3, 4, 6, 7, 10, 12, and 13, ZmNF-YB15, and ZmNF-YC3 and 9 were suppressed by drought stress. ZmNF-YA3, ZmNF-YA8 and ZmNF-YA12 were upregulated after infection by the three pathogens, while ZmNF-YA1 and ZmNF-YB2 were suppressed. These results indicate that the ZmNF-Ys may have significant roles in the response to abiotic and biotic stresses. - Highlights: • We indicated a total of 50 members of ZmNF-Y gene family in maize genome. • We analyzed gene structure, protein architecture of ZmNF-Y genes. • Evolution pattern and phylogenic relationships were analyzed among 50 ZmNF-Y genes. • Expression pattern of ZmNF-Ys were detected in various maize tissues. • Transcript levels of ZmNF-Ys were measured under various abiotic and biotic stresses.« less

Graduate Research Assistant Program for Professional Development at Oak Ridge National Laboratory (ORNL) Global Nuclear Security Technology Division (GNSTD)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eipeldauer, Mary D; Shelander Jr, Bruce R

2012-01-01

The southeast is a highly suitable environment for establishing a series of nuclear safety, security and safeguards 'professional development' courses. Oak Ridge National Laboratory (ORNL) provides expertise in the research component of these subjects while the Y-12 Nuclear Security Complex handles safeguards/security and safety applications. Several universities (i.e., University of Tennessee, Knoxville (UTK), North Carolina State University, University of Michigan, and Georgia Technology Institute) in the region, which offer nuclear engineering and public policy administration programs, and the Howard Baker Center for Public Policy make this an ideal environment for learning. More recently, the Institute for Nuclear Security (INS) wasmore » established between ORNL, Y-12, UTK and Oak Ridge Associate Universities (ORAU), with a focus on five principal areas. These areas include policy, law, and diplomacy; education and training; science and technology; operational and intelligence capability building; and real-world missions and applications. This is a new approach that includes professional development within the graduate research assistant program addressing global needs in nuclear security, safety and safeguards.« less

40 CFR 12.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

Methods for Estimating Physicochemical Properties of Inorganic Chemicals of Environmental Concern.

DTIC Science & Technology

1984-06-01

atoms from a solid surface into an adjacent vapor phase. This effect has had significant implications for environmental pollution in the case of 210 ...for industrial 55 An um tt, i • purposes, 210 - polonium becomes unstable with respect to spontaneous migration through the air, leading to severe...1.6x10 s 8xlO- 210 -lead 210P 22 y 3.7x107 * 210 - polonium 210 -(5.30 14eV) 138 d 6.4x105 Po 91 AAfdr DL futt, imc Table 12. SELECTED RADIONUCLIDES WITH HALF

40 CFR 148.12 - Waste specific prohibitions-California list wastes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Waste specific prohibitions-California list wastes. 148.12 Section 148.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS Prohibitions on Injection § 148.12...

40 CFR 12.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... organizations representing individuals with handicaps to, participate in the self-evaluation process by... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Self-evaluation. 12.110 Section 12.110... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.110 Self-evaluation...

40 CFR 65.12 - Delegation of authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Delegation of authority. 65.12 Section 65.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE General Provisions § 65.12 Delegation of authority. (a) In delegating...

40 CFR 65.12 - Delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Delegation of authority. 65.12 Section 65.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE General Provisions § 65.12 Delegation of authority. (a) In delegating...

National Dam Safety Program. Welch Lake Dam (MO 10733), Missouri - Kansas City Basin, Boone County, Missouri. Phase I Inspection Report.

DTIC Science & Technology

1981-03-01

Operating Facilities 10 4.4 Description of Any Warning System in Effect 10 4.5 Evaluation 10 SECTION 5 - HIDRAULIC /HYDROLOGIC 5.1 Evaluation of Features 11...Hm + 1/4L Y) A = 1/2 T (2d -A Y)c Q = (A 3 g/T) 0 .5 where: d = critical depth (feet) H c = available specific energy which is taken to be the heightm

78 FR 51734 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Health Sciences Special Emphasis Panel Expedited Review of Biorepository Project. Date: September 12..., Nat. Institute of Environmental Health Sciences, Office of Program Operations, Scientific Review...

Deradicalization or Disengagement : A Framework for Encouraging Jihad Abandonment

DTIC Science & Technology

2016-06-10

resulted in entire group disengagement, while the German HAYAT Program and Saudi Counseling Program seek individual de-radicalization/disengagement... Counseling Y Optional N/A Y Y Family Counseling N Y N Y Y Practical Support Measures Y Y Y Y Y Disengage Guarantee – Type Y - Family N Y – Group N...disengagement. The U.S. could easily support religious counseling in de-radicalization programs in partner nations overseas. Group or Individual Programs

Precollege Program for Native American Students in Environmental Studies, June 13, 1993 - July 1, 1993. Final Report.

ERIC Educational Resources Information Center

Wisconsin Univ., Madison. Inst. for Environmental Studies.

Staff and graduate students from the University of Wisconsin conducted a 3-week workshop in environmental studies at Lac Courte Oreilles Community College for adolescent Native American students. Eleven girls and nine boys, aged 12-17, from six tribes enrolled in the program. Nineteen completed all 3 weeks. The curriculum covered such topics as…

Reciprocal Education Experiences In Two GK-12 Programs: Teachers Learning And Students Teaching In Diverse Settings

NASA Astrophysics Data System (ADS)

Mayo, M.; Williams, C.; Rodriguez, T.; Greely, T.; Pyrtle, A. J.; Rivera-Rentas, A. L.; Vilches, M.

2004-12-01

The National Science Foundation's Graduate Teaching Fellows in K-12 Education (GK-12) Program has enabled science, technology, engineering and mathematics (STEM) graduate schools across the country to become more active in local area K-12 schools. An overview of a graduate student's experiences, insights gained and lessons learned as a Fellow in the 2003-2004 Universidad Metropolitana's (UMET) environmental science and the 2004-2005 University of South Florida's (USF) ocean science GK-12 Programs is presented. The major goals of the 2003-2004 UMET GK-12 Program were 1) to enrich environmental science teaching and learning via a thematic approach in eight local public schools and 2) to provide UMET graduate students with exposure to teaching methodologies and practical teaching experience. Utilizing examples from local environments in and nearby Carolina, Puerto Rico to teach key science principles at Escuela de la Comunidad Juana Rodriguez Mundo provided numerous opportunities to relate science topics to students' daily life experiences. By 2004, the UMET GK-12 Program had successfully engaged the entire student body (primarily comprised of bilingual minority kindergarten to sixth graders), teachers and school administrators in environment-focused teaching and learning activities. Examples of such activities include tree planting projects to minimize local erosion, conducting a science fair for the first time in many years, and numerous opportunities to experience what "real scientists do" while conducting environmental science investigations. During the 2004-2005 academic year, skills, insights and lessons learned as a UMET GK-12 Fellow are being further enhanced through participation in the USF GK-12 OCEANS Program. The overall objectives of the 2004-2005 USF GK-12 OCEANS assignment at Madeira Beach Elementary School in Saint Petersburg, Florida are to 1) engage students from various ethnic backgrounds and cultures in hands-on science activities, 2) enhance the school's third grade ocean science education curriculum, and 3) foster dialog between students at Madeira Beach Elementary School and Escuela de la Comunidad Juana Rodriguez Mundo, via exchange of pictures, video recordings, letters and emails related to environment-focused learning activities being undertaken at the two schools. In addition to these objectives, during the 2004-2005 academic year several ocean science-focused activities, the majority of which were adapted and/or identified from either the UMET GK-12 or USF OCEAN GK-12 Programs, will be utilized to further stimulate Madeira Beach Elementary School third graders' critical thinking skills. Examples of such activities, including hands-on exercises, case studies, games and field trips are highlighted in this presentation.

40 CFR 53.12 - Request for hearing on cancellation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Request for hearing on cancellation. 53.12 Section 53.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) AMBIENT AIR MONITORING REFERENCE AND EQUIVALENT METHODS General Provisions § 53.12 Request for...

40 CFR 160.12 - Statement of compliance or non-compliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Statement of compliance or non-compliance. 160.12 Section 160.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS GOOD LABORATORY PRACTICE STANDARDS General Provisions § 160.12 Statement of compliance or...

Oak Ridge Reservation annual site environmental report for 2008

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2009-09-01

The Oak Ridge Reservation (ORR) consists of three major government-owned, contractor-operated facilities: the Y-12 National Security Complex, Oak Ridge National Laboratory, and East Tennessee Technology Park. The ORR was established in the early 1940s as part of the Manhattan Project, a secret undertaking that produced materials for the first atomic bombs. The reservation’s role has evolved over the years, and it continues to adapt to meet the changing defense, energy, and research needs of the United States. Both the work carried out for the war effort and subsequent research, development, and production activities have involved, and continue to involve, themore » use of radiological and hazardous materials. The Oak Ridge Reservation Annual Site Environmental Report and supporting data are available at http://www.ornl.gov/sci/env_rpt or from the project director. This document is prepared annually to summarize environmental activities, primarily environmental monitoring activities, on the Oak Ridge Reservation (ORR) and within the ORR surroundings. The document fulfills the requirement of Department of Energy (DOE) Order 231.1A, Environment, Safety and Health Reporting, for an annual summary of environmental data to characterize environmental performance. The environmental monitoring criteria are described in DOE Order 450.1A, Environmental Protection Program. The results summarized in this report are based on data collected prior to and through 2008. This report is not intended to provide the results of all sampling on the ORR. Additional data collected for other site and regulatory purposes, such as environmental restoration/remedial investigation reports, waste management characterization sampling data, and environmental permit compliance data, are presented in other documents that have been prepared in accordance with applicable DOE guidance and/or laws and are referenced herein as appropriate. Corrections to the report for the previous year are found in Appendix A. Appendix B contains a glossary of technical terms that may be useful for clarifying some of the language used in this document.« less

Final Environmental Impact Statement (EIS) for the Space Nuclear Thermal Propulsion (SNTP) Program. Sanitized Version. Appendices

DTIC Science & Technology

1991-09-19

and lcom y (U) 3.2-32 3.2.2.1.2 Land Useand IW au (U) 3.2-32 3.2.2.1.3 Noise (U) 3.2-36 3.2.2.1.4 Historic and ArchaolosicAl lcaurves (U) 3.2-36 I, p...and inhalation shielding factor. The total organ dose is then determined ! y summing te component doprs received from each pathway and each...2.078E+01 Sr-90 5.307E+00 Ge-75 3.256E+02 Sr-91 2.247E+05 Ge-77 1.240E+02 Sr-92 9.517E+05 Ge-78 5.980E+03 Sr-93 1.559E+07 As-76 2.793E-03 Y -90 1.980E

JPRS Report Environmental Issues.

DTIC Science & Technology

1990-11-02

Program Views Environmental Effects [0 GLOBO 30 Sep] ............................. 31 Environmental Affairs Institute Fines Illegal Amazon Lumber...ERICA 12 Oct] .................................................................................................. 33 PERU Court Nullifies Soviet Fishing...34. He said loss of forests in Burma remains at only 0.3 He disputed reports that logs are being cut down ran- percent of forest cover per year, or

78 FR 56902 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-16

... Institute of Environmental Health Sciences, Office of Program Operations, Scientific Review Branch, P.O. Box... Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Health Sciences Special Emphasis Panel; Pathway to Independence Review. Date: October 10, 2013. Time: 12...

75 FR 72727 - Addition of National Toxicology Program Carcinogens; Community Right-to-Know Toxic Chemical...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... is (202) 566-1752. FOR FURTHER INFORMATION CONTACT: Daniel R. Bushman, Environmental Analysis Division, Office of Information Analysis and Access (2842T), Environmental Protection Agency, 1200... Environmental Information, Office of Information Analysis and Access. August 12, 2010. 4. NTP, 2005. National...

Household food insecurity is associated with anemia in adult Mexican women of reproductive age.

PubMed

Fischer, Nils C; Shamah-Levy, Teresa; Mundo-Rosas, Verónica; Méndez-Gómez-Humarán, Ignacio; Pérez-Escamilla, Rafael

2014-12-01

Anemia is a major cause of maternal mortality. Household food insecurity (HFI) may increase the risk of anemia among women of reproductive age although this hypothesis remains largely untested in representative samples from low- and middle-income countries. Our objective was to investigate the association of HFI with anemia in a nationally representative, cross-sectional sample of Mexican women of reproductive age (12-49 y old). We tested the association between HFI and anemia among 16,944 women of reproductive age using the multiple logistic regression among adolescent (12-20 y) and adult women (21-49 y). HFI was measured with the use of the Latin American and Caribbean Food Security Scale. Hemoglobin was measured with capillary hemoglobin with the use of HemoCue photometer (HemoCue, Inc.) and anemia was defined with the use of WHO standards. The association of HFI and anemia was not significant (P > 0.05) for adolescent women (12-20 y), whereas in adult women (21-49 y), the adjusted odds of having anemia were 31-43% higher among those living in mild to severely food insecure households than adult women residing in food secure households (P < 0.05). HFI is associated with anemia among adult Mexican women. Programs that reduce HFI may also be effective at reducing the risk of anemia among Mexican women. © 2014 American Society for Nutrition.

Novel health economic evaluation of a vaccination strategy to prevent HPV-related diseases: the BEST study.

PubMed

Favato, Giampiero; Baio, Gianluca; Capone, Alessandro; Marcellusi, Andrea; Costa, Silvano; Garganese, Giorgia; Picardo, Mauro; Drummond, Mike; Jonsson, Bengt; Scambia, Giovanni; Zweifel, Peter; Mennini, Francesco S

2012-12-01

The development of human papillomavirus (HPV)-related diseases is not understood perfectly and uncertainties associated with commonly utilized probabilistic models must be considered. The study assessed the cost-effectiveness of a quadrivalent-based multicohort HPV vaccination strategy within a Bayesian framework. A full Bayesian multicohort Markov model was used, in which all unknown quantities were associated with suitable probability distributions reflecting the state of currently available knowledge. These distributions were informed by observed data or expert opinion. The model cycle lasted 1 year, whereas the follow-up time horizon was 90 years. Precancerous cervical lesions, cervical cancers, and anogenital warts were considered as outcomes. The base case scenario (2 cohorts of girls aged 12 and 15 y) and other multicohort vaccination strategies (additional cohorts aged 18 and 25 y) were cost-effective, with a discounted cost per quality-adjusted life-year gained that corresponded to €12,013, €13,232, and €15,890 for vaccination programs based on 2, 3, and 4 cohorts, respectively. With multicohort vaccination strategies, the reduction in the number of HPV-related events occurred earlier (range, 3.8-6.4 y) when compared with a single cohort. The analysis of the expected value of information showed that the results of the model were subject to limited uncertainty (cost per patient = €12.6). This methodological approach is designed to incorporate the uncertainty associated with HPV vaccination. Modeling the cost-effectiveness of a multicohort vaccination program with Bayesian statistics confirmed the value for money of quadrivalent-based HPV vaccination. The expected value of information gave the most appropriate and feasible representation of the true value of this program.

The Simple Map for Single-null Divertor Tokamak : How to Find Chaos

NASA Astrophysics Data System (ADS)

Martinez, Ilissa; Ali, Halima; Punjabi, Alkesh

2000-10-01

The Simple Map^1 represents the magnetic field inside a single-null divertor tokamak. The Simple map is given by the equations X_n+1=X_n-KYn (1-Y_n) and Y_n+1=Y_n+KX_n+1. We fix k at 0.6 and X0 at 0. We choose two different starting values of Y_0. These two values are very close together. These values of Y0 represent two field lines which start out very close together. We calculate the distance between two field lines as n is increased. This distance is given by d_n. For both equations given by the distance formula (d_n=[Y_n,2-Y_n,1)^2+(X_n,2-X_n,1)^2]. If dn increases exponentially as n is increased we find chaos, if dn does not increase exponentially then you have not found chaos. We have found chaos, Y0 must be less than one, but higher than 0.9971 for chaos. For Y0 between 0 and 0.9971, there is no chaos. This work is supported by US DOE OFES. Ms. Ilissa Martinez is a HU CFRT Summer Fusion High School Workshop Scholar from the Blanca Malaret High School in Puerto Rico. She is supported by NASA SHARP Plus Program. 1. Punjabi A, Verma A and Booze A, Phys Rev Lett 69 3322 (1992) and J Plasma Phys 52 91 (1994)

40 CFR 105.12 - How is the awards review committee selected?

Code of Federal Regulations, 2014 CFR

2014-07-01

... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based on...

40 CFR 105.12 - How is the awards review committee selected?

Code of Federal Regulations, 2011 CFR

2011-07-01

... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based on...

40 CFR 105.12 - How is the awards review committee selected?

Code of Federal Regulations, 2012 CFR

2012-07-01

... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based on...

40 CFR 135.12 - Contents of notice.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Contents of notice. 135.12 Section 135.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PRIOR NOTICE OF CITIZEN SUITS Prior Notice Under the Safe Drinking Water Act § 135.12 Contents of notice. (a...

40 CFR 135.12 - Contents of notice.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Contents of notice. 135.12 Section 135.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PRIOR NOTICE OF CITIZEN SUITS Prior Notice Under the Safe Drinking Water Act § 135.12 Contents of notice. (a...

40 CFR 105.12 - How is the awards review committee selected?

Code of Federal Regulations, 2010 CFR

2010-07-01

... selected? 105.12 Section 105.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT Selection Criteria § 105.12 How is the awards review... water pollution control agencies. The number of participants in a nominations review process is based on...

40 CFR 78.12 - Standard of review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Standard of review. 78.12 Section 78.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.12 Standard of review. (a) On appeal of a decision of the Administrator prior to...

Neural Correlates of the Y Chromosome in Autism: XYY Syndrome as a Genetic Model

DTIC Science & Technology

2017-09-01

AWARD NUMBER: W81XWH-15-1-0354 TITLE: Neural correlates of the Y chromosome in autism: XYY Syndrome as Genetic Model PRINCIPAL INVESTIGATOR...0354 XYY Syndrome as a Genetic Model 5b. GRANT NUMBER 15T c. PROGRAM ELEMENT NUMBER 15T6. AUTHOR(S) Timothy Roberts 15T d. PROJECT NUMBER Judith...remaining 12 months of this award. 15T 5. SUBJECT TERMS Autism spectrum disorder, ASD; 47,XYY syndrome (XYY); neuroimaging; MRI; MEG; Comorbid behaviors

Comprehensive Synchronization Elimination for Java (PREPRINT)

DTIC Science & Technology

2003-01-01

e : % thread-local % reentrant % enclosed Figure...0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 ca ss ow ar y ja va c ja va cu p ja va do c jg l jle x pi zz a ar ra y in st an td b jlo go pl as m a sl ic e Figure 6...1998. [DR98] P. Diniz and M. Rinard. Lock Coarsening: Eliminating Lock Overhead in Automatically Parallelized Object-based Programs. In Journal

Weight loss and dropout during a commercial weight-loss program including a very-low-calorie diet, a low-calorie diet, or restricted normal food: observational cohort study.

PubMed

Hemmingsson, Erik; Johansson, Kari; Eriksson, Jonas; Sundström, Johan; Neovius, Martin; Marcus, Claude

2012-11-01

The effectiveness of commercial weight-loss programs consisting of very-low-calorie diets (VLCDs) and low-calorie diets (LCDs) is unclear. The aim of the study was to quantify weight loss and dropout during a commercial weight-loss program in Sweden (Itrim; cost: $1300/€1000; all participants paid their own fee). This observational cohort study linked commercial weight-loss data with National Health Care Registers. Weight loss was induced with a 500-kcal liquid-formula VLCD [n = 3773; BMI (in kg/m(2)): 34 ± 5 (mean ± SD); 80% women; 45 ± 12 y of age (mean ± SD)], a 1200-1500-kcal formula and food-combination LCD (n = 4588; BMI: 30 ± 4; 86% women; 50 ± 11 y of age), and a 1500-1800-kcal/d restricted normal-food diet (n = 676; BMI: 29 ± 5; 81% women; 51 ± 12 y of age). Maintenance strategies included exercise and a calorie-restricted diet. Weight loss was analyzed by using an intention-to-treat analysis (baseline substitution). After 1 y, mean (±SD) weight changes were -11.4 ± 9.1 kg with the VLCD (18% dropout), -6.8 ± 6.4 kg with the LCD (23% dropout), and -5.1 ± 5.9 kg with the restricted normal-food diet (26% dropout). In an adjusted analysis, the VLCD group lost 2.8 kg (95% CI: 2.5, 3.2) and 3.8 kg (95% CI: 3.2, 4.5) more than did the LCD and restricted normal-food groups, respectively. A high baseline BMI and rapid initial weight loss were both independently associated with greater 1-y weight loss (P < 0.001). Younger age and low initial weight loss predicted an increased dropout rate (P < 0.001). Treatment of depression (OR: 1.4; 95% CI: 1.1, 1.9) and psychosis (OR: 2.6; 95% CI: 1.1, 6.3) were associated with an increased dropout rate in the VLCD group. A commercial weight-loss program, particularly one using a VLCD, was effective at reducing body weight in self-selected, self-paying adults.

Birth Weight Is Associated With the IGF-1 Response to GH in Children: Programming of the Anabolic Action of GH?

PubMed

Donzeau, Aurélie; Bouhours-Nouet, Natacha; Fauchard, Mathilde; Decrequy, Anne; Mathieu, Elisabeth; Boux de Casson, Florence; Gascoin, Geraldine; Coutant, Régis

2015-08-01

Intrauterine programming of the somatotropic axis has been hypothesized in cases of intrauterine growth retardation. The objective of the study was to study the effects of birth weight and body composition on GH sensitivity. This was a cross-sectional study with a single GH administration to assess GH sensitivity. The study was conducted at the Department of Pediatric Endocrinology of an academic medical center. One hundred normal short children aged from 4 to 17 years old (44 girls, 56 boys) separated into four groups: early childhood (aged 4-8 y, n = 14), late childhood (aged 9-12 y, pubertal stage 1, n = 30), early puberty (aged 10-15 y, stage 2, n = 32), and midpuberty (aged 12-17 y, stages 3 and 4, n = 24). Serum IGF-1 at baseline and 24 hours after a single administration of GH (2 mg/m(2)) were measured. δIGF-1 significantly increased across the groups (P < .0001) with no gender difference, whereas the percentage of change in IGF-1 was similar (47% ± 32%). Independent predictors of δIGF-1 were birth weight SD score, fat percentage, fasting insulin (all positive predictors), and free fatty acids (negative predictor), with age, puberty, and baseline IGF-1 as adjusting variables (multiple R = 0.73, P < .0001). Independent predictors of the percentage of change in IGF-1 were birth weight SD score, fat percentage, and baseline IGF-1 (multiple R = 0.43, P < .001). This study suggests that in cases of low birth weight, intrauterine programming of GH sensitivity may be an adaptation to an expected poor postnatal nutritional environment, serving to restrict the anabolic action of GH. Conversely, postnatal excess energy stores may promote the anabolic action of GH.

40 CFR 1400.12 - Qualified researchers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Qualified researchers. 1400.12 Section 1400.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY AND DEPARTMENT OF JUSTICE ACCIDENTAL RELEASE PREVENTION REQUIREMENTS; RISK MANAGEMENT PROGRAMS UNDER THE CLEAN AIR ACT SECTION 112(r)(7...

Incidence and Mortality Rates and Clinical Characteristics of Type 1 Diabetes among Children and Young Adults in Cochabamba, Bolivia

PubMed Central

Duarte Gómez, Elizabeth; Gregory, Gabriel Andrew; Castrati Nostas, Miriam; Middlehurst, Angela Christine; Jenkins, Alicia Josephine

2017-01-01

Objectives To determine incidence, mortality, and clinical status of youth with diabetes at the Centro Vivir con Diabetes, Cochabamba, Bolivia, with support from International Diabetes Federation Life for a Child Program. Methods Incidence/mortality data analysis of all cases (<25 year (y)) diagnosed January 2005–February 2017 and cross-sectional data (December 2015). Results Over 12.2 years, 144 cases with type 1 diabetes (T1D) were diagnosed; 43.1% were male. Diagnosis age was 0.3–22.2 y; peak was 11-12 y. 11.1% were <5 y; 29.2%, 5–<10 y; 43.1%, 10–<15 y; 13.2%, 15–<20 y; and 3.5%, 20–<25 y. The youngest is being investigated for monogenic diabetes. Measured incidence in Cercado Province (Cochabamba Department) was 2.2/100,000 children < 15 y/y, with ≈80% ascertainment, giving total incidence of 2.7/100,000 children < 15 y/y. Two had died. Crude mortality rate was 2.3/1000 patient years. Clinical data on 141 cases <35 y: mean/median HbA1c was 8.5/8.2% (69/62 mmol/mol), levels higher in adolescents. Three were on renal replacement therapy; four others had substantial renal impairment. Elevated BMI, triglycerides, and cholesterol were common: 19.1%, 18.3%, and 39.1%, respectively. Conclusions Bolivia has low T1D incidence. Reasonable glycemic control is being achieved despite limited resources; however, some have serious complications and adverse cardiovascular risk factor profiles. Further attention is needed for complications. PMID:28948172

Consequence assessment for Airborne Releases of SO{sub 2} from the Y-12 Pilot Dechlorination Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pendergrass, W.R.

The Atmospheric Turbulence and Diffusion Division was requested by the Department of Energy`s Oak Ridge Operations Office to conduct a consequence assessment for potential atmospheric releases of SO{sub 2} from the Y-12 Pilot Dechlorination Facility. The focus of the assessment was to identify ``worst`` case meteorology which posed the highest concentration exposure potential for both on-site as well as off-site populations. A series of plausible SO{sub 2} release scenarios were provided by Y-12 for the consequence assessment. Each scenario was evaluated for predictions of downwind concentration, estimates of a five-minute time weighted average, and estimate of the dimension of themore » puff. The highest hazard potential was associated with Scenario 1, in which a total of eight SO{sub 2} cylinders are released internally to the Pilot Facility and exhausted through the emergency venting system. A companion effort was also conducted to evaluate the potential for impact of releases of SO{sub 2} from the Pilot Facility on the population of Oak Ridge. While specific transport trajectory data is not available for the Pilot Facility, extrapolations based on the Oak Ridge Site Survey and climatological records from the Y-12 meteorological program does not indicate the potential for impact on the city of Oak Ridge. Steering by the local topographical features severely limits the potential impact ares. Due to the lack of specific observational data, both tracer and meteorological, only inferences can be made concerning impact zones. It is recommended tat the Department of Energy Oak Ridge Operations examine the potential for off-site impact and develop the background data to prepare impact zones for releases of hazardous materials from the Y-12 facility.« less

Environmental Education Report: Empirical Evidence, Exemplary Models, and Recommendations on the Impact of Environmental Education on K-12 Students

ERIC Educational Resources Information Center

Wheeler, Gilda; Thumlert, Colleen; Glaser, Lise; Schoellhamer, Matt; Bartosh, Oksana

2007-01-01

This study examined reports and programs from across the state, the nation and from international sources to gather a broad selection of published and unpublished environmental education research. A variety of sources were used, such as the internet, interviews with key informants and experts in the field of environmental and sustainability…

Site characterization summary report for dry weather surface water sampling upper East Fork Poplar Creek characterization area Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This report describes activities associated with conducting dry weather surface water sampling of Upper East Fork Poplar Creek (UEFPC) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. This activity is a portion of the work to be performed at UEFPC Operable Unit (OU) 1 [now known as the UEFPC Characterization Area (CA)], as described in the RCRA Facility Investigation Plan for Group 4 at the Oak- Ridge Y-12 Plant, Oak Ridge, Tennessee and in the Response to Comments and Recommendations on RCRA Facility Investigation Plan for Group 4 at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee, Volume 1,more » Operable Unit 1. Because these documents contained sensitive information, they were labeled as unclassified controlled nuclear information and as such are not readily available for public review. To address this issue the U.S. Department of Energy (DOE) published an unclassified, nonsensitive version of the initial plan, text and appendixes, of this Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) Plan in early 1994. These documents describe a program for collecting four rounds of wet weather and dry weather surface water samples and one round of sediment samples from UEFPC. They provide the strategy for the overall sample collection program including dry weather sampling, wet weather sampling, and sediment sampling. Figure 1.1 is a schematic flowchart of the overall sampling strategy and other associated activities. A Quality Assurance Project Plan (QAPJP) was prepared to specifically address four rounds of dry weather surface water sampling and one round of sediment sampling. For a variety of reasons, sediment sampling has not been conducted and has been deferred to the UEFPC CA Remedial Investigation (RI), as has wet weather sampling.« less

Green Schools That Don't Cost Too Much.

ERIC Educational Resources Information Center

Fickes, Michael

2003-01-01

Describes the U.S. Green Building Council program, Leadership in Environmental and Energy Design, that has helped school districts around the country apply comprehensive environmental techniques to the design of 34 K-12 school buildings since 1999. (SLD)

USHPRR FUEL FABRICATION PILLAR: FABRICATION STATUS, PROCESS OPTIMIZATIONS, AND FUTURE PLANS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wight, Jared M.; Joshi, Vineet V.; Lavender, Curt A.

The Fuel Fabrication (FF) Pillar, a project within the U.S. High Performance Research Reactor Conversion program of the National Nuclear Security Administration’s Office of Material Management and Minimization, is tasked with the scale-up and commercialization of high-density monolithic U-Mo fuel for the conversion of appropriate research reactors to use of low-enriched fuel. The FF Pillar has made significant steps to demonstrate and optimize the baseline co-rolling process using commercial-scale equipment at both the Y-12 National Security Complex (Y-12) and BWX Technologies (BWXT). These demonstrations include the fabrication of the next irradiation experiment, Mini-Plate 1 (MP-1), and casting optimizations at Y-12.more » The FF Pillar uses a detailed process flow diagram to identify potential gaps in processing knowledge or demonstration, which helps direct the strategic research agenda of the FF Pillar. This paper describes the significant progress made toward understanding the fuel characteristics, and models developed to make informed decisions, increase process yield, and decrease lifecycle waste and costs.« less

Development of an Analysis Method to Identify the Root Causes of Finding from the Air Force Environmental Compliance Assessment and Management Program (ECAMP)

DTIC Science & Technology

1994-09-01

Theories and Applications ..................... 17 Theories of Motivation ........................... 18 Maslow’s Hierarchy of Needs...18 Herzberg’s Motivation-Hygiene Theory ............. 19 Instrinsic vs Extrinsic Assumptions ................... 22 McGregor’s Theory X and Theory ...Y Assumptions ...... ... 22 Vroom’s Expectancy Theory ..................... 24 Applications ........ .......................... 25 Tell People What

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

Chairman of the House Committee on Science and Technology U.S. Rep. Sherwood Boehlert, R-N.Y., questions witnesses during a hearing on the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

An Investigation of the Reacting and Non-Reacting Flow Characteristics of Solid Fuel Ramjets.

DTIC Science & Technology

1980-09-01

which was run on the IBM-360 computer at the Naval 23 Postgraduate School. Programs for Texas Instruments TI - 59 programmable calculator were utilized...Pc’ F P A e 12 = g(y+l) F + PA e-TT 2(R F (9) lil Equations 7, 8, and 9 were solved for each run by software programs written for the TI - 59 programmable calculator . The

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

Making the Case for Sustainable K-12 School Environmental Health Programs

ERIC Educational Resources Information Center

Belle, Kara; Utebay, Kudret; McArthur, Ashley

2012-01-01

The U.S. Environmental Protection Agency (EPA) offers resources to help a school or school district improve the environmental health and energy performance of its facilities, and in many cases, apply the savings generated through improved energy efficiency toward facility improvements, for the betterment of students, faculty, and staff. As an…

Dynamical correlation functions of the quadratic coupling spin-Boson model

NASA Astrophysics Data System (ADS)

Zheng, Da-Chuan; Tong, Ning-Hua

2017-06-01

The spin-boson model with quadratic coupling is studied using the bosonic numerical renormalization group method. We focus on the dynamical auto-correlation functions {C}O(ω ), with the operator \\hat{O} taken as {\\hat{{{σ }}}}x, {\\hat{{{σ }}}}z, and \\hat{X}, respectively. In the weak-coupling regime α < {α }{{c}}, these functions show power law ω-dependence in the small frequency limit, with the powers 1+2s, 1+2s, and s, respectively. At the critical point α ={α }{{c}} of the boson-unstable quantum phase transition, the critical exponents y O of these correlation functions are obtained as {y}{{{σ }}x}={y}{{{σ }}z}=1-2s and {y}X=-s, respectively. Here s is the bath index and X is the boson displacement operator. Close to the spin flip point, the high frequency peak of {C}{{{σ }}x}(ω ) is broadened significantly and the line shape changes qualitatively, showing enhanced dephasing at the spin flip point. Project supported by the National Key Basic Research Program of China (Grant No. 2012CB921704), the National Natural Science Foundation of China (Grant No. 11374362), the Fundamental Research Funds for the Central Universities, China, and the Research Funds of Renmin University of China (Grant No. 15XNLQ03).

Magnetic properties of quadruple perovskite solid solutions Ca{sub 1–x}Y{sub x}Cu{sub 3}Fe{sub 4}O{sub 12} and Y{sub 1–y}Ce{sub x}Cu{sub 3}Fe{sub 4}O{sub 12}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murakami, Makoto; Mori, Shigeo; Yamada, Ikuya, E-mail: i-yamada@21c.osakafu-u.ac.jp

Magnetic properties of the quadruple perovskite solid solutions Ca{sub 1–x}Y{sub x}Cu{sub 3}Fe{sub 4}O{sub 12} and Y{sub 1–y}Ce{sub y}Cu{sub 3}Fe{sub 4}O{sub 12} are investigated. Ca{sub 1–x}Y{sub x}Cu{sub 3}Fe{sub 4}O{sub 12} shows continuous increase in the ferromagnetic transition temperature as x increases. Y{sub 1–y}Ce{sub y}Cu{sub 3}Fe{sub 4}O{sub 12} exhibits a ferromagnetic-antiferromagnetic transition in the vicinity of y = 0.5. These observations demonstrate the electron doping effect on magnetic properties of charge-disproportionated ACu{sub 3}Fe{sub 4}O{sub 12} phases.

The role of a conserved tyrosine residue in high-potential iron sulfur proteins.

PubMed Central

Iwagami, S. G.; Creagh, A. L.; Haynes, C. A.; Borsari, M.; Felli, I. C.; Piccioli, M.; Eltis, L. D.

1995-01-01

Conserved tyrosine-12 of Ectothiorhodospira halophila high-potential iron sulphur protein (HiPIP) iso-I was substituted with phenylalanine (Y12F), histidine (Y12H), tryptophan (Y12W), isoleucine (Y12I), and alanine (Y12A). Variants Y12A and Y12I were expressed to reasonable levels in cells grown at lower temperatures, but decomposed during purification. Variants Y12F, Y12H, and Y12W were substantially destabilized with respect to the recombinant wild-type HiPIP (rcWT) as determined by differential scanning calorimetry over a pH range of 7.0-11.0. Characterization of the Y12F variant by NMR indicates that the principal structural differences between this variant and the rcWT HiPIP result from the loss of the two hydrogen bonds of the Tyr-12 hydroxyl group with Asn-14 O delta 1 and Lys-59 NH, respectively. The effect of the loss of the latter interaction is propagated through the Lys-59/Val-58 peptide bond, thereby perturbing Gly-46. The delta delta GDapp of Y12F of 2.3 kcal/mol with respect to rcWT HiPIP (25 degrees C, pH 7.0) is entirely consistent with the contribution of these two hydrogen bonds to the stability of the latter. CD measurements show that Tyr-12 influences several electronic transitions within the cluster. The midpoint reduction potentials of variants Y12F, Y12H, and Y12W were 17, 19, and 22 mV (20 mM MOPS, 0.2 M sodium chloride, pH 6.98, 25 degrees C), respectively, higher than that of rcWT HiPIP. The current results indicate that, although conserved Tyr-12 modulates the properties of the cluster, its principle function is to stabilize the HiPIP through hydrogen bonds involving its hydroxyl group and electrostatic interactions involving its aromatic ring. PMID:8580847

Solar Environmental Disturbances

DTIC Science & Technology

2007-11-02

like stars were examined, extending the previous 7–12 year time series to 13–20 years by combining Strömgren b, y photometry from Lowell Observatory...per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...explanations for how these physical processes affect the production of solar activity, both on short and long time scales. Solar cycle variation

45 CFR 12a.9 - Application process.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for local zoning regulations. (3) Description of the proposed program. The applicant must fully...) Environmental information. The applicant must provide sufficient information to allow HHS to analyze the... provided with the application packet. HHS will assist applicants in obtaining any pertinent environmental...

40 CFR 131.43 - Florida.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Florida. 131.43 Section 131.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS... Department of Environmental Protection (FDEP), or successor agencies. (12) Stream means a free-flowing...

Plutonium working group report on environmental, safety and health vulnerabilities associated with the department`s plutonium storage. Volume II, Appendix B, Part 9: Oak Ridge site site team report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-09-01

This report provides the input to and results of the Department of Energy (DOE) - Oak Ridge Operations (ORO) DOE Plutonium Environment, Safety and Health (ES & H) Vulnerability Assessment (VA) self-assessment performed by the Site Assessment Team (SAT) for the Oak Ridge National Laboratory (ORNL or X-10) and the Oak Ridge Y-12 Plant (Y-12) sites that are managed by Martin Marietta Energy Systems, Inc. (MMES). As initiated (March 15, 1994) by the Secretary of Energy, the objective of the VA is to identify and rank-order DOE-ES&H vulnerabilities associated for the purpose of decision making on the interim safe managementmore » and ultimate disposition of fissile materials. This assessment is directed at plutonium and other co-located transuranics in various forms.« less

40 CFR 104.12 - Certification of record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Certification of record. 104.12 Section 104.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PUBLIC... transcript his certificate stating that, to the best of his knowledge and belief, the transcript is a true...

40 CFR 104.12 - Certification of record.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Certification of record. 104.12 Section 104.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PUBLIC... transcript his certificate stating that, to the best of his knowledge and belief, the transcript is a true...

40 CFR 104.12 - Certification of record.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Certification of record. 104.12 Section 104.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PUBLIC... transcript his certificate stating that, to the best of his knowledge and belief, the transcript is a true...

40 CFR 104.12 - Certification of record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Certification of record. 104.12 Section 104.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PUBLIC... transcript his certificate stating that, to the best of his knowledge and belief, the transcript is a true...

Installation Restoration Program. Phase II. Confirmation/Quantification. Stage I. Tyndall Air Force Base, Florida.

DTIC Science & Technology

1984-08-01

10 31984 . PREPARED FOR UNITED STATES AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LABORATORY BROOKS AIR FORCE BASE, TEXAS 78235 ,,c.’p! ed di...Force August 1984 Occupational and Environmental Health Laboratory I3 NUMBER OF PAGES Aerospace Medical Division (AFSC) 249 total pages• ~~Brooks Air...PROGRAM BACKGROUND i-I 1.2 FACILITY HISTORY 1-3 1.3 DISPOSAL SITE DESCRIPTIONS 1-b 1.4 PROJECT STAFF 1-20 2.0 ENVIRONMENTAL SETTING 2-1 2.1 METEOROLOGY 2-1

The AMTEX Partnership{trademark} mid year report, fiscal year 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-03-01

The AMTEX Partnership{trademark} is a collaborative research and development program among the US Integrated Textile Complex (ITC), the US Department of Energy (DOE), the DOE national laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating US jobs. Three AMTEX projects funded in FY 1997 are Diamond Activated Manufacturing Architecture (DAMA), Computer-Aided Fabric Evaluation (CAFE), and Textile Resource Conservation (TReC). The five sites involved in AMTEX work are Sandia National Laboratory (SNL), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), the Oak Ridgemore » Y-12 Plant, and the Oak Ridge National Laboratory (ORNL) (the latter is funded through Y-12).« less

Usual Vitamin Intakes by Mexican Populations.

PubMed

Pedroza-Tobías, Andrea; Hernández-Barrera, Lucía; López-Olmedo, Nancy; García-Guerra, Armando; Rodríguez-Ramírez, Sonia; Ramírez-Silva, Ivonne; Villalpando, Salvador; Carriquiry, Alicia; Rivera, Juan A

2016-09-01

In the past several years, the consumption of high-energy, nutrient-poor foods has increased globally. Dietary intake data collected by the National Health and Nutrition Survey (ENSANUT) 2012 provide information to assess the quality of the Mexican diet and to guide food and nutrition policy. The aim was to describe the usual intake and the prevalence of inadequate intakes of vitamins for the overall Mexican population and by subgroups defined by sex, age, region, urban or rural areas, and socioeconomic status (SES). ENSANUT 2012 is a cross-sectional probabilistic survey representative of the Mexican population. Dietary information was collected by using the 24-h recall automated multiple-pass method (n = 10,096) with a repeated measurement on a subsample (n = 889) to permit adjustment for intraindividual variability with the use of the Iowa State University method. Mean usual intakes and the prevalence of inadequate intakes of thiamin, riboflavin, niacin, folate, and vitamins A, D, E, C, B-6, and B-12 were calculated for children aged 1-4 y (CH1-4y), children aged 5-11 y (CH5-11y), adolescents aged 12-19 y, and adults aged ≥20 y. In all of the age groups, prevalences of inadequate intakes of vitamins D and E were the highest (77-99% of adults and adolescents and 53-95% of CH5-11y and CH1-4y) and those of folate and vitamin A were intermediate (47-70% of adults and adolescents, 15-23% of CH5-11y and 8-13% of CH1-4y), whereas those of thiamin, riboflavin, niacin, and vitamins B-6, B-12, and C were the lowest (0-37% of adults, 1-27% of adolescents, and 0-2.4% of CH5-11y and CH1-4y). With few exceptions, the highest prevalences of inadequate intakes for vitamins were observed in the poorest populations (rural South region and the lowest tertile of SES). The intake of vitamins among Mexicans is inadequate overall. Information collected by ENSANUT can help target food assistance programs and develop strategies to prevent vitamin deficiencies. © 2016 American Society for Nutrition.

Year 2000 compliance issues.

PubMed

1999-03-01

This month, we continue our coverage of the year 2000 (Y2K) problem as it affects healthcare facilities and the professionals who work in them. We present the following articles: "Checking PCs for Y2K Compliance"--In this article, we describe the probable sources of Y2K-related errors in PCs and present simple procedures for testing the Y2K compliance of PCs and application software. "Y2K Assessment Equipment Expectations"--In this article, we review the Y2K compliance data from a small sampling of hospitals to help answer the question "What percentage of medical equipment will likely be susceptible to Y2K problems?" "Y2K Labeling of Medical Devices"--In this article, we discuss the pros and cons of instituting a program to label each medical device with its Y2K status. Also in this section, we present an updated list of organizations that support ECRI's Position Statement on the testing of medical devices for Y2K compliance, which we published in the December 1998 issue of Health Devices (27[12]). And we remind readers of the services ECRI can offer to help healthcare institutions cope with the Y2K problem.

Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 18. Part 1B: Citations with abstracts, sections 10 through 16

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-09-01

This bibliography contains 3,638 citations with abstracts of documents relevant to environmental restoration, nuclear facility decontamination and decommissioning (D and D), uranium mill tailings management, and site remedial actions. The bibliography contains scientific, technical, financial, and regulatory information that pertains to DOE environmental restoration programs. The citations are separated by topic into 16 sections, including (1) DOE Environmental Restoration Program; (2) DOE D and D Program; (3) Nuclear Facilities Decommissioning; (4) DOE Formerly Utilized sites Remedial Action Program; (5) NORM-Contaminated Site Restoration; (6) DOE Uranium Mill Tailings Remedial Action Project; (7) Uranium Mill Tailings Management; (8) DOE Site-Wide Remedial Actions;more » (9) DOE Onsite Remedial Action Projects; (10) Contaminated Site Remedial Actions; (11) DOE Underground Storage Tank Remediation; (12) DOE Technology Development, Demonstration, and Evaluation; (13) Soil Remediation; (14) Groundwater Remediation; (15) Environmental Measurements, Analysis, and Decision-Making; and (16) Environmental Management Issues.« less

40 CFR 147.550 - State-administered program.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... (1) Oil and Gas and Deep Drilling Act of 1975, Official Code of Georgia Annotated (O.C.G.A.) §§ 12-4... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.550 Section 147.550 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...

40 CFR 147.550 - State-administered program.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... (1) Oil and Gas and Deep Drilling Act of 1975, Official Code of Georgia Annotated (O.C.G.A.) §§ 12-4... 40 Protection of Environment 23 2014-07-01 2014-07-01 false State-administered program. 147.550 Section 147.550 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...

40 CFR 147.550 - State-administered program.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... (1) Oil and Gas and Deep Drilling Act of 1975, Official Code of Georgia Annotated (O.C.G.A.) §§ 12-4... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. 147.550 Section 147.550 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...

COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION, AND LIABILITY INFORMATION SYSTEM (CERCLIS)

EPA Science Inventory

The Superfund program was created as a result of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). CERCLA was enacted on 12/11/80, and amended by the Superfund Amendments and Reauthorization Act of 1986. These acts established broad authority for...

Headwaters: The Next Stage in High School Integrated Programming

ERIC Educational Resources Information Center

Elrick, Michael

2007-01-01

For 12 years, Centennial High School in Guelph has run an integrated program called the Community Environmental Leadership Program (CELP). In 1995 the program was offered at the grade 11 level. The program ran successfully in the second semester for seven years. In 2001, with the high school system being modified to fit into a four-year model, and…

Munition Penetration Depth Prediction: SERDP SEED Project MR 2629

DTIC Science & Technology

2017-08-01

ER D C/ CR RE L TR -1 7- 12 Strategic Environmental Research and Development Program (SERDP) Munition Penetration-Depth Prediction...release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and... Research and Development Program (SERDP) ERDC/CRREL TR-17-12 August 2017 Munition Penetration-Depth Prediction SERDP SEED Project MR-2629 Arnold J

40 CFR 355.12 - What quantities of extremely hazardous substances trigger emergency planning requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false What quantities of extremely hazardous substances trigger emergency planning requirements? 355.12 Section 355.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS...

TAT [Training and Technology.

ERIC Educational Resources Information Center

Oak Ridge Associated Universities, TN. Manpower Development Div.

The Oak Ridge Associated Universities (ORAU) of Tennessee and the Nuclear Division of the Union Carbide Corporation established an industrial training program called Training and Technology (TAT) which was conducted at the Oak Ridge Y-12 plant. TAT instructors were provided by the regular work force of Union Carbide while ORAU provided the…

A Sequential Quadratic Programming Algorithm Using an Incomplete Solution of the Subproblem

DTIC Science & Technology

1990-09-01

Electr6nica e Inform’itica Industrial E.T.S. Ingenieros Industriales Universidad Polit6cnica, Madrid Technical Report SOL 90-12 September 1990 -Y...MURRAY* AND FRANCISCO J. PRIETOt *Systems Optimization Laboratory Department of Operations Research Stanford University tDept. de Automitica, Ingenieria

Research Experience for Undergraduates Program in Multidisciplinary Environmental Science

NASA Astrophysics Data System (ADS)

Wu, M. S.

2012-12-01

During summers 2011 and 12 Montclair State University hosted a Research Experience for Undergraduates Program (REU) in transdisciplinary, hands-on, field-oriented research in environmental sciences. Participants were housed at the Montclair State University's field station situated in the middle of 30,000 acres of mature forest, mountain ridges and freshwater streams and lakes within the Kittatinny Mountains of Northwest New Jersey, Program emphases were placed on development of project planning skills, analytical skills, creativity, critical thinking and scientific report preparation. Ten students were recruited in spring with special focus on recruiting students from underrepresented groups and community colleges. Students were matched with their individual research interests including hydrology, erosion and sedimentation, environmental chemistry, and ecology. In addition to research activities, lectures, educational and recreational field trips, and discussion on environmental ethics and social justice played an important part of the program. The ultimate goal of the program is to facilitate participants' professional growth and to stimulate the participants' interests in pursuing Earth Science as the future career of the participants.

Environmental Impact Research Program. Gravel Bar Mussel Communities: A Community Model.

DTIC Science & Technology

1987-10-01

flowing waters, where all but the coarse substrate has washed away, have stone flies, mayflies, blackflies, and caddis flies adapted for attachment and...bivalve genera are very important in the faunas of estuarine and fresh waters, as are the more diverse groups of freshwater gastropods . The only...relatively permanent river systems. In - their soft parts most freshwater mussels are structural>y rather stereotyped. UnIonaceans show adaptive

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, D.H.

In 1992 there were over 6,000 employees involved in defense related activities at the Y-12 Plant. By late 1994 the plant had undergone a dramatic change in operations including a reduction of the work force to less than 4,000 employees. That this major downsizing was accomplished without a layoff is a tribute to the combined efforts of the Y-12 employees, union leadership, the DOE, Martin Marietta and local and state governments. The keys to the success are: (1) the end of the Cold War and the potential impact was recognized early and a plan of action was developed and implemented,more » the plan was based on a total reorientation of the historical role and mode of operation of the plant; (2) everyone who had an interest in the outcome was invited to join in the planning; (3) the plan was developed and implemented as if no barriers to success existed; (4) opening about one-third of the classified portion of the Y-12 Plant as the initial activity was critical to the success of the plan. The historical opening of the gates was a major factor in convincing employees and a skeptical public that change could and would occur. As the debate on the future of the DOE weapons complex evolves it is clear that the Y-12 Plant will be a major contributor to improving productivity and the competitiveness of current and future industry in Tennessee and the country while continuing to provide unique expertise to support the nation`s nuclear weapons program.« less

40 CFR 74.12 - Opt-in permit contents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Opt-in permit contents. 74.12 Section 74.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE OPT-INS Permitting Procedures § 74.12 Opt-in permit contents. (a) The opt-in permit shall be included in the Acid Rain permit. (b)...

Environmental analysis of the operation of Oak Ridge National Laboratory (X-10 site)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyle, J.W.; Blumberg, R.; Cotter, S.J.

1982-11-01

An environmental analysis of the operation of the Oak Ridge National Laboratory (ORNL) facilities in Bethel Valley and Melton Valley was conducted to present to the public information concerning the extent to which recognizable effects, or potential effects, on the environment may occur. The analysis addresses current operations of the ORNL X-10 site and completed operations that may continue to have residual effects. Solid wastes from ORNL operations at the Y-12 site which are transported to the X-10 site for burial (e.g., Biology Division animal wastes) are included as part of X-10 site operation. Socioeconomic effects are associated primarily withmore » the communities where employees live and with the Knoxville Bureau of Economic Analysis economic area as a whole. Therefore, ORNL employees at both Y-12 and X-10 sites are included in the ORNL socioeconomic impact analysis. An extensive base of environmental data was accumulated for this report. Over 80 reports related to ORNL facilities and/or operations are cited as well as many open-literature citations. Environmental effects of the operation of ORNL result from operational discharges from the onsite facilities; construction and/or modification of facilities, transportation to and from the site of persons, goods and services; socioeconomic impacts to the local, regional, and general population; and accidental discharges if they should occur. Operational discharges to the environnment are constrained by federal, state, and local regulations and by criteria established by the US Department of Energy to minimize adverse impacts. It is the purpose of this document to evaluate the operation of the ORNL insofar as impacts beyond the site boundary may occur or have the potential for occurrence.« less

Building 9401-2 Plating Shop Surveillance and Maintenance Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1999-05-01

This document provides a plan for implementing surveillance and maintenance (S and M) activities to ensure that Building 9401-2 Plating Shop is maintained in a cost effective and environmentally secure configuration until subsequent closure during the final disposition phase of decommissioning. U.S. Department of Energy (DOE) G430.1A-2, Surveillance and Maintenance During Facility Disposition (1997), was used as guidance in the development of this plan. The S and M Plan incorporates DOE O 430.1A, Life Cycle Asset Management (LCAM) (1998a) direction to provide for conducting surveillance and maintenance activities required to maintain the facility and remaining hazardous and radioactive materials, wastes,more » and contamination in a stable and known condition pending facility disposition. Recommendations in the S and M plan have been made that may not be requirement-based but would reduce the cost and frequency of surveillance and maintenance activities. During the course of S and M activities, the facility's condition may change so as to present an immediate or developing hazard or unsatisfactory condition. Corrective action should be coordinated with the appropriate support organizations using the requirements and guidance stated in procedure Y10-202, Rev. 1, Integrated Safety Management Program, (Lockheed Martin Energy Systems, Inc. (LMES), 1998a) implemented at the Oak Ridge Y-12 Plant and the methodology of the Nuclear Operations Conduct of Operations Manual (LMES, 1999) for the Depleted Uranium Operations (DUO) organization. The key S and M objectives applicable to the Plating Shop are to: Ensure adequate containment of remaining residual material in exhaust stacks and outside process piping, stored chemicals awaiting offsite shipment, and items located in the Radioactive Material Area (RMA); Provide access control into the facility and physical safety to S and M personnel; Maintain the facility in a manner that will protect the public, the environment, and the S and M personnel; Provide an S and M plan which identifies and complies with applicable environmental, safety, and health safeguards and security requirements; and Provide a cost effective S and M program for the plating shop, Building 9401-2.« less

Environmental Education, K-12.

ERIC Educational Resources Information Center

Thomson, Janet

The Environmental Education program of Great Falls Public Schools, which was Montana's state winner in the National Science Teacher Association 1986 Search for Excellence in Science Education, is described in this report. An overview is presented of the district's policies, administrative procedures, staff development plans, and curriculum and…

Unconventional Transcriptional Response to Environmental Enrichment in a Mouse Model of Rett Syndrome

PubMed Central

Kerr, Bredford; Silva, Pamela A.; Walz, Katherina; Young, Juan I.

2010-01-01

Background Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2) and one of the leading causes of mental retardation in females. RTT is characterized by psychomotor retardation, purposeless hand movements, autistic-like behavior and abnormal gait. We studied the effects of environmental enrichment (EE) on the phenotypic manifestations of a RTT mouse model that lacks MeCP2 (Mecp2 −/y). Principal Findings We found that EE delayed and attenuated some neurological alterations presented by Mecp2 −/y mice and prevented the development of motor discoordination and anxiety-related abnormalities. To define the molecular correlate of this beneficial effect of EE, we analyzed the expression of several synaptic marker genes whose expression is increased by EE in several mouse models. Conclusions/Significance We found that EE induced downregulation of several synaptic markers, suggesting that the partial prevention of RTT-associated phenotypes is achieved through a non-conventional transcriptional program. PMID:20634955

Bioassessment of the Standard Elutriate Test

DTIC Science & Technology

1976-09-01

that the growth of the green algal, Chlorella vulgaris , was reduced approximately 50 percent in the presence of 2.0 ppm zinc. Payne (12) reported that...Environmental Protection Agency, Washington, DC, Oct., 1973. 14. Rachlin, Y. W., and Farran, M., "Growth Response of the Green Algae Chlorella ... vulgaris to Selective Concentrations of Zinc," Water Research, Vol. 8, 1974, pp. 575-577. 1:). Standard Methods for the Examination of Water and Wastewater

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (83rd, Phoenix, Arizona, August 9-12, 2000). Science Communication Interest Group.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Science Communication Interest Group section of the proceedings contains the following five papers: "Accounting for the Complexity of Causal Explanations in the Wake of an Environmental Risk" (LeeAnn Kahlor, Sharon Dunwoody and Robert J. Griffin); "Construction of Technology Crisis and Safety: News Media's Framing the Y2K…

Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.

PubMed

Savi, Pierre; Herbert, Jean-Marc

2005-04-01

Ticlopidine and clopidogrel belong to the same chemical family of thienopyridine adenosine diphosphate (ADP)-receptor antagonists. They have shown their efficacy as platelet antiaggregant and antithrombotic agents in many animal models, both ex vivo and in vivo. Although ticlopidine was discovered more than 30 years ago, it was only recently that the mechanism of action of ADP-receptor antagonists was characterized in detail. Ticlopidine and clopidogrel both behave in vivo as specific antagonists of P2Y (12), one of the ADP receptors on platelets. Metabolic steps that involve cytochrome P450-dependent pathways are required to generate the active metabolite responsible for this in vivo activity. The active moiety is a reactive thiol derivative that targets P2Y (12) on platelets. The interaction is irreversible, accounting for the observation that platelets are definitely antiaggregated, even if no active metabolite is detectable in plasma. The interaction is specific for P2Y (12); other purinoceptors such as P2Y (1) and P2Y (13) are spared. This results in inhibition of the binding of the P2Y (12) agonist 2-methylthio-ADP and the ADP-induced downregulation of adenylyl cyclase. Platelet aggregation is affected not only when triggered by ADP but also by aggregation inducers when used at concentrations requiring released ADP as an amplifier. The efficacy and safety of clopidogrel has been established in several large, randomized, controlled trials. The clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) trial demonstrated the superiority of clopidogrel over acetylsalicylic acid (ASA) in patients at risk of ischemic events, including ischemic stroke, myocardial infarction (MI), and peripheral arterial disease. The clopidogrel in unstable angina to prevent recurrent ischemic events (CURE) trial showed a sustained, incremental benefit when clopidogrel was added to standard therapy (including ASA) in patients with unstable angina and non-Q-wave MI. The clopidogrel for the reduction of events during observation (CREDO) trial demonstrated the benefit of continuing clopidogrel (plus ASA) for 12 months, as opposed to 1 month, after percutaneous coronary intervention. The proven efficacy of clopidogrel, coupled with its favorable safety and tolerability profile, has prompted its evaluation in an extensive, ongoing clinical trial program that will help to further characterize the benefit of clopidogrel in patients with a range of atherothrombotic profiles.

Defense Environmental Restoration Program Annual Report to Congress for Fiscal Year 1988

DTIC Science & Technology

1989-03-01

63 6 1 17 36 IOWA 3 49 49 0 3 7 0 0 1 5 IDAHO 15 34 34 0 2 10 0 0 1 5 ILLINOIS 14 140 131 6 12 34 1 1 10 15 INDIANA 12 122 119 0 4 39 3 0 3 7 KANSAS 8...4 4 IOWA TOTALS 49 0 3 7 0 0 1 5 IDAHO ARMY ARCO AEC SITE 1 BONNEVILLE 1 BROKEN KETTLE TRAINING AREA 1 BUHL 1 GOODING I GOWEN FIELD 1 HALLEY 1 IDAHO ... IDAHO TOTALS 34 0 2 10 0 0 1 5 B- 13 Table B-2 DEPARTMENT OF DEFENSE ENVIRONMENTAL RESTORATION PROGRAM State by State Installation Status Listing (As

Green Power Partnership Top 30 K-12 Schools

EPA Pesticide Factsheets

The U.S. EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. On this list are the largest green power users among K-12 school partners within the GPP.

Intrinsic resonances and AC-dipole simulations of 3He in the AGS Booster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hock, Kiel; Meot, Francois; Huang, Haixin

Polarized 3He collisions are part of future RHIC physics programs and of the eRHIC project. The anomalous magnetic moment of 3He (G=-4.184) is roughly three times greater than that of protons (G=1.793), a polarized species that is already used at the Collider-Accelerator complex at BNL. Because of the higher anomolous magnetic moment and possibly injecting into the AGS at rigidities beyond 7 T • m, 3He may have to cross depolarizing intrinsic resonances while accelerating in the Booster. To overcome these strong intrinsic resonances we look to an AC-dipole, which will need to be installed in the Booster. An AC-dipolemore » is a magnet that induces large betatron oscillations which forces the entire bunch to experience a stronger resonance and induce a spin flip of all particles. An artificial intrinsic resonance is created, with close proximity to the original intrinsic resonance, which requires simulations to gauge what magnet strength is required. Simulations have been performed using zgoubi regarding the resonances 0 + v y, 12 - v y, and 6 + v y and show that the AC-dipole is effective at overcoming these resonances. Benefits of avoiding the 0 + v y and crossing the 12 - v y and 6 + v y in the Booster presents the advantage of allowing injection above the 0 + v y in the AGS and minimizes the orbit distortions from the snakes.« less

Environmental and Community Health: Individualized Health Incentive Program Modules for Physically Disabled Students for Grades Kindergarten Through Twelve. Teacher's Edition.

ERIC Educational Resources Information Center

Reggio, Kathryn D.; And Others

The fourth in a series of health education modules for physically handicapped students (grades K-12) centers on environmental and community health. Considered in an introductory section are definitions and descriptions of nine types of physical disabilities, and reviewed are learning activities in environmental and community health at The Human…

The Right Tools for the Job: How Can Aquatic Resource Education Succeed in the Classroom?

ERIC Educational Resources Information Center

Fortner, Rosanne W.

Because of its bases in science and stewardship, aquatic resource education may be seen as a type of environmental education. The range of environmental education (EE) programs includes a huge variety designed for different groups and settings. This chapter takes the perspective of environmental education as it is done in the formal K-12 classroom…

Final Environmental Assessment/Overseas Environmental Assessment Joint Strile Fighter System Development and Demonstration Developmental Test Program

DTIC Science & Technology

2007-01-01

tte r t es t a...ct iv iti es . Pr op os ed p er fo rm an ce te st s w ou ld c oi nc id e w ith F Q , f lu tte r, hi gh A ng le -o f- A tta ck ( A oA ), an...cl os el y in te gr at ed w ith th e FQ , f lu tte r, an d hi gh A oA te st s a nd w ou ld g en er al ly p ro ce ed in c on ce rt

2011 Remediation Effectiveness Report for the U.S. Department of Energy Oak Ridge Reservation, Oak Ridge, Tennessee - Data and Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bechtel Jacobs

2011-03-01

Under the requirements of the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency, (EPA) and the Tennessee Department of Environment and Conservation (TDEC) in 1992, all environmental restoration activities on the ORR are performed in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Since the 1990s, the environmental restoration activities have experienced a gradual shift from characterization to remediation. As this has occurred, it has been determined that the assessment of the individual and cumulative performance of all ORR CERCLA remedial actionsmore » (RAs) is most effectively tracked in a single document. The Remediation Effectiveness Report (RER) is an FFA document intended to collate all ORR CERCLA decision requirements, compare pre- and post-remediation conditions at CERCLA sites, and present the results of any required post-decision remediation effectiveness monitoring. First issued in 1997, the RER has been reissued annually to update the performance histories of completed actions and to add descriptions of new CERCLA actions. Monitoring information used in the 2011 RER to assess remedy performance was collected and/or compiled by DOE's Water Resources Restoration Program (WRRP). Only data used to assess performance of completed actions are provided. In addition to collecting CERCLA performance assessment data, the WRRP also collects baseline data to be used to gauge the effectiveness of future actions once implemented. These baseline data are maintained in the Oak Ridge Environmental Information System and will be reported in future RERs, as necessary, once the respective actions are completed. However, when insufficient data exist to assess the impact of the RAs, e.g., when the RA was only recently completed, a preliminary evaluation is made of early indicators of effectiveness at the watershed scale, such as contaminant trends at surface water integration points (IFs). Long-term stewardship (LTS) information used in this report is collected, compiled, and tracked by the WRRP in conjunction with the Bechtel Jacobs Company LLC (BJC) Surveillance and Maintenance (S&M) program, the BJC Radiation Protection Organization at East Tennessee Technology Park (ETTP), ETTP Environmental Compliance Program, B&W Y-12 Liquid Waste Treatment Operations, and UT Battelle Facilities Management Division. Additionally, documentation verifying the implementation of administrative land use controls (LUCs) [i.e., property record restrictions, property record notices, zoning notices, and excavation/penetration permit (EPP) program] is also obtained from many sources throughout the fiscal year (FY), including County Register of Deeds offices for property record restrictions and property record notices, City Planning Commission for zoning notices, and BJC project engineers for EPP program verification. Copies of this documentation are obtained by the WRRP and maintained with the project RER files.« less

Training and Technology. Report of Program Activities January 1--June 30, 1973. Conducted at the U.S. Atomic Energy Commissions Oak Ridge Y-12 Plant. Summary Report.

ERIC Educational Resources Information Center

Oak Ridge Associated Universities, TN. Manpower Development Div.

The report is a description of the program activities carried on by Training and Technology (TAT) during the first six months of 1973. In the general category of manpower research and development, brief but detailed descriptions are given of each of the projects conducted in the development and extension of the TAT training model in Albuquerque,…

GHG MITIGATION TECHNOLOGY PERFORMANCE EVALUATIONS UNDERWAY AT THE GHG TECHNOLOGY VERIFICATION CENTER

EPA Science Inventory

The paper outlines the verification approach and activities of the Greenhouse Gas (GHG) Technology Verification Center, one of 12 independent verification entities operating under the U.S. EPA-sponsored Environmental Technology Verification (ETV) program. (NOTE: The ETV program...

Defense Logistics Agency Support for Environmental Sustainability - Products and Services Supporting Environmental Requirements

DTIC Science & Technology

2011-05-12

SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION /AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY...Logistics Agency Support for Environmental Sustainability 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT...NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Defense Logistics Agency,Environmental Office,Fort

Development of a Comprehensive Base-Level Environmental Training Program for Total Environmental Compliance

DTIC Science & Technology

1994-09-01

Business Managers. Ed. Betty Seldner. San Francisco : McGraw Hill, Inc., 1994 11. Gunderson, John. "Federal Facilities Compliance Act," in Environmental...Decision Making for Engineering and Business Managers. Ed. Betty Seldner. San Francisco : McGraw Hill, Inc., 1994 105 12. Heyman, Glenn. "The Role and...San Francisco . McGraw Hill, Inc., 1994 13- Hill, Chuck. Environmental Oversight Branch, Headquarters Air Combat Command. Personal Correspondence

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

Chairman of the House Committee on Science and Technology U.S. Rep. Sherwood Boehlert, R-N.Y., left, shakes hands with NASA Administrator Michael Griffin prior to a hearing on the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

14 CFR 171.311 - Signal format requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1037 30 77X 113.00 1101 12 1164 12 ** 77Y 113.05 1101 36 1038 30 78X 113.10 1102 12 1165 12 ** 78Y 113... more than ±10 KHz from the assigned frequency. Any one transmitter frequency must not vary more than... * 13X 1037 12 974 12 ** 13Y 1037 36 1100 30 * 14X 1038 12 975 12 ** 14Y 1038 36 1101 30 * 15X 1039 12...

Economic analysis of the first 20 years of universal hepatitis B vaccination program in Italy: an a posteriori evaluation and forecast of future benefits.

PubMed

Boccalini, Sara; Taddei, Cristina; Ceccherini, Vega; Bechini, Angela; Levi, Miriam; Bartolozzi, Dario; Bonanni, Paolo

2013-05-01

Italy was one of the first countries in the world to introduce a routine vaccination program against HBV for newborns and 12-y-old children. From a clinical point of view, such strategy was clearly successful. The objective of our study was to verify whether, at 20 y from its implementation, hepatitis B universal vaccination had positive effects also from an economic point of view. An a posteriori analysis evaluated the impact that the hepatitis B immunization program had up to the present day. The implementation of vaccination brought an extensive reduction of the burden of hepatitis B-related diseases in the Italian population. As a consequence, the past and future savings due to clinical costs avoided are particularly high. We obtained a return on investment nearly equal to 1 from the National Health Service perspective, and a benefit-to-cost ratio slightly less than 1 for the Societal perspective, considering only the first 20 y from the start of the program. In the longer-time horizon, ROI and BCR values were positive (2.78 and 2.46, respectively). The break-even point was already achieved few years ago for the NHS and for the Society, and since then more and more money is progressively saved. The implementation of universal hepatitis B vaccination was very favorable during the first 20 y of adoption, and further benefits will be increasingly evident in the future. The hepatitis B vaccination program in Italy is a clear example of the great impact that universal immunization is able to provide in the medium-long-term when health care authorities are so wise as to invest in prevention.

St. Louis Airport Site. Annual site environmental report, calendar year 1985. Formerly Utilized Sites Remedial Action Program (FUSRAP). Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-09-01

During 1985, the environmental monitoring program was continued at the St. Louis Airport Site (SLAPS) in St. Louis County, Missouri. The ditches north and south of the site have been designated for cleanup as part of the Formerly Utilized Sites Remedial Action Program (FUSRAP). The monitoring program at the SLAPS measures radon gas concentrations in air; external gamma radiation dose rates; and uranium, thorium, and radium concentrations in surface water, groundwater, and sediment. Potential radiation doses to the public are also calculated. Because the site is not controlled or regulated by the DOE, the DOE Derived Concentration Guides (DCGs) aremore » not applicable to SLAPS, but are included only as a basis for comparison. The DOE DCGs and the DOE radiation protection standard have been revised. (Appendix B). During 1985, annual average radon levels in air at the SLAPS were below the DCG for uncontrolled areas. External gamma monitoring in 1985 showed measured annual gamma dose rates ranging from 3 to 2087 mrem/y, with the highest value occurring in an area known to be contaminated. The calculated maximum dose at the site boundary, assuming limited occupancy, would be 6 mrem/y. Average annual concentrations of /sup 230/Th, /sup 226/Ra, and total uranium in surface waters remained below the DOE DCG. The on-site groundwater measurements showed that average annual concentrations of /sup 230/Th, /sup 226/Ra and total uranium were within the DOE DCGs. Although there are no DCGs for sediments, all concentrations of total uraniu, /sup 230/Th, and /sup 226/Ra were below the FUSRAP Guidelines.« less

Characterization and Disposition of Legacy Low-Level Waste at the Y-12 National Security Complex - 12133

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tharp, Tim; Donnelly, Jim

2012-07-01

The Y-12 National Security Complex (Y-12) is concluding a multi-year program to characterize and dispose of all legacy low-level waste (LLW). The inventory of legacy waste at Y-12 has been reduced from over 3500 containers in Fiscal Year (FY) 2000 to 6 containers at the end of FY2011. In addition, the site recently eliminated the inventory of other low-level waste that is greater than 365 days old (i.e., >365-Day LLW), to be in full compliance with DOE Order 435.1. A consistent technical characterization approach emerged for both of these populations of backlogged waste: (1) compile existing historical data and processmore » knowledge and conduct interviews with site personnel; (2) inspect the containers and any tags, labels, or other markings to confirm or glean additional data; (3) with appropriate monitoring, open the container, visually inspect and photograph the contents while obtaining preliminary radiological surveys; (4) obtain gross weight and field non-destructive assay (NDA) data as needed; (5) use the non-public Oak Ridge Reservation Haul Road to ship the container to a local offsite vendor for waste sorting and segregation; (6) sort, drain, sample, and remove prohibited items; and (7) compile final data and prepare for shipment to disposal. After disposing of this backlog, the focus has now turned to avoiding the recurrence of this situation by maintaining low inventories of low-level waste and shortening the duration between waste generation and disposal. An enhanced waste tracking system and monthly metric charts are used to monitor and report progress to contractor and federal site office management. During the past 2 years, the average age of LLW onsite at Y-12 has decreased from more than 180 days to less than 60 days. (authors)« less

Social-Physical Environment 8.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul.

The ninth of thirteen units for an environmental education curriculum is presented in this teacher's guide. The collection of units for grades K-12 was written in response to a mandate from the Minnesota State Legislature through a bill making provisions for developing and implementing a state-wide environmental education program. The units are…

Comptox Chemistry Dashboard: Web-Based Data Integration Hub for Environmental Chemistry and Toxicology Data (ACS Fall meeting 4 of 12)

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrate advances in biology, chemistry, exposure and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and da...

75 FR 55846 - Draft Re-Evaluation for Environmental Impact Statement: Sikorsky Memorial Airport, Stratford, CT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

..., Environmental Program Manager, Federal Aviation Administration New England, 12 New England Executive Park... Memorial Airport in Stratford, Connecticut. The document will assist the FAA in determining the suitability... following locations: FAA New England Region, 16 New England Executive Park, Burlington, MA, 781-238-7613...

A Supplementary Program for Environmental Education, Music, High School.

ERIC Educational Resources Information Center

Warpinski, Robert

Presented in this teacher's guide for grades 10-12 are lesson plans and ideas for integrating music and environmental education. Each lesson originates with a fundamental concept pertaining to the environment and states, in addition, its discipline area, subject area, and problem orientation. Following this, behavioral objectives and suggested…

An interactive computer program for sizing spacecraft momentum storage devices

NASA Technical Reports Server (NTRS)

Wilcox, F. J., Jr.

1980-01-01

An interactive computer program was developed which computes the sizing requirements for nongimbled reaction wheels, control moment gyros (CMG), and dual momentum control devices (DMCD) used in Earth-orbiting spacecraft. The program accepts as inputs the spacecraft's environmental disturbance torques, rotational inertias, maneuver rates, and orbital data. From these inputs, wheel weights are calculated for a range of radii and rotational speeds. The shape of the momentum wheel may be chosen to be either a hoop, solid cylinder, or annular cylinder. The program provides graphic output illustrating the trade-off potential between the weight, radius, and wheel speed. A number of the intermediate calculations such as the X-, Y-, and Z-axis total momentum, the momentum absorption requirements for reaction wheels, CMG's, DMCD's, and basic orbit analysis information are also provided as program output.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goins, L.F.; Webb, J.R.; Cravens, C.D.

This publication contains 1035 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions. These citations constitute the thirteenth in a series of reports prepared annually for the US Department of Energy (DOE) Environmental Restoration programs. Citations to foreign and domestic literature of all types. There are 13 major sections of the publication, including: (1) DOE Decontamination and Decommissioning Program; (2) Nuclear Facilities Decommissioning; (3) DOE Formerly Utilized Sites Remedial Action Program; (4) DOE Uranium Mill Tailings Remedial Action Project; (5) Uranium Mill Tailings Management; (6) DOE Environmental Restoration Program; (7) DOE Site-Specific Remedialmore » Actions; (8) Contaminated Site Restoration; (9) Remediation of Contaminated Soil and Groundwater; (10) Environmental Data Measurements, Management, and Evaluation; (11) Remedial Action Assessment and Decision-Making; (12) Technology Development and Evaluation; and (13) Environmental and Waste Management Issues. Bibliographic references are arranged in nine subject categories by geographic location and then alphabetically by first author, corporate affiliation, or publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word.« less

The Envirothon and its effects on students' environmental literacy

NASA Astrophysics Data System (ADS)

Weiser, Brenda Gayle

During the past thirty years, significant progress has been made in defining environmental education and its goals, and operationally by the emerging concept of environmental literacy. Environmental literacy includes affective, behavioral, and cognitive components. Roth (1992) includes environmental sensitivity, knowledge, skills, attitudes and values, personal investment and responsibility, and active involvement as components of environmental literacy. In addition, Simmons (1995) identifies affect, ecological knowledge, socio-political knowledge, knowledge of environmental issues, skills, environmentally responsible behaviors, and additional determinants of environmentally responsible behaviors as components of environmental literacy. Environmental education is the primary vehicle for promoting environmental literacy. Most K through 12 environmental education is delivered in non-formal programs outside traditional curriculum and instruction and is exemplified by the National Envirothon program. Student teams compete to demonstrate their knowledge and understanding of ecological principles in aquatics, forestry, soils, wildlife, and a selected environmental issue. Each year over 75,000 high school students participate in the Envirothon. The purpose of the study was to identify the effects of Envirothon participation on its high school students from 17 out of 43 states with Envirothon programs. One hundred forty eight students completed the Wisconsin Environmental Literacy Assessment Instrument; (Peri, 1996), to assess their environmental literacy status. Data were analyzed using an analysis of covariance where the pretest was the covariate. The results indicated the participation in the Envirothon program does make a statistically significant difference between the environmental literacy of those high school students who have participated in the Envirothon program and the environmental literacy of those high school students who have not participated in the Envirothon program in the cognitive component of environmental literacy but does not in the affective and behavioral components of environmental literacy. Results also indicated there was not a statistically significant difference between the environmental literacy of those high school students who have participated in one or more Envirothon competitions and the environmental literacy of those high school students who have participated in less than one Envirothon competition in regard to the cognitive, affective, or behavior components of environmental literacy. The implication is participating in the Envirothon program does make a difference in the environmental literacy of those high school students participating in the Envirothon program in the cognitive component of environmental literacy but participating in the Envirothon program does not increase the environmental literacy of those high school students participating in the Envirothon program in the affective or behavioral components of environmental literacy. This information is important to teachers, advisors, state and national Envirothon committee members, and sponsors relating to the international goals, objectives and key points, study materials, and training methodology as each is used to expand and strengthen Envirothon programs. Furthermore, many fenders are interested in the program and how it is affecting the students. Recommendations for further research include conducting a meta-analysis using this research and the research conducted by Meredith (1996), longitudinal studies, and case studies utilizing past Envirothon students. Documentation through news articles and interviews could assist in assessing the Envirothon program's impact on students. This would not evaluate the student's environmental literacy, but would provide information on how the Envirothon program influences students' life choices.

Environmental practices for biomedical research facilities.

PubMed Central

Medlin, E L; Grupenhoff, J T

2000-01-01

As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement of for-profit companies and government agencies. The designation "facilities" includes all related buildings and grounds, "green auditing" of buildings and programs, purchasing of furnishings and sources, energy efficiency, and engineering services (lighting, heating, air conditioning), among other activities. The committee made a number of recommendations, including development of a national council for environmental stewardship in biomedical research, development of a system of green auditing of such research facilities, and creation of programs for sustainable building and use. In addition, the committee recommended extension of education and training programs for environmental stewardship, in cooperation with facilities managers, for all research administrators and researchers. These programs would focus especially on graduate fellows and other students, as well as on science labs at levels K--12. PMID:11121360

Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies.

PubMed

Jeong, Young-Hoon; Bliden, Kevin P; Antonino, Mark J; Park, Ki-Soo; Tantry, Udaya S; Gurbel, Paul A

2012-07-01

We analyzed the antiplatelet effects of different P2Y(12) receptor blockers with VerifyNow P2Y12 assay (VN-P2Y12) and light transmittance aggregometry (LTA). The point-of-care VN-P2Y12 has been used to assess the antiplatelet effects in clopidogrel-treated patients but has not been evaluated in detail in patients treated with ticagrelor. Patients were randomly assigned to either ticagrelor [180 mg loading/90 mg twice daily (n = 37)] or clopidogrel [600 mg loading/75 mg daily (n = 39)] on top of aspirin treatment, and platelet reactivity was measured serially during onset, maintenance, and offset phases. High on-treatment platelet reactivity (HPR) was defined as 5 and 20 μM adenosine diphosphate-induced maximal platelet aggregation ≥46% and ≥59%, respectively, and P2Y12 reaction units ≥235. Platelet function measured by VN-P2Y12 correlated well with LTA (.812 ≤ ρ ≤ .823, P < .001). VN-P2Y12 "BASE" values were consistent during administration of both agents. Calculated and reported percent inhibitions by VN-P2Y12 were similar (difference, -0.6%; 95% agreement limits, -22.9% to 21.6%). Platelet inhibition by VN-P2Y12 during clopidogrel and ticagrelor administrations was comparable to platelet inhibition by LTA. HPR determined by LTA and VN-P2Y12 were well matched, and the risk stratification between the two methods showed strong agreement after both therapies (κ > .7). The VerifyNow P2Y12 assay is effective in assessing the antiplatelet effects and in identifying HPR during clopidogrel or ticagrelor therapy. Copyright © 2012 Mosby, Inc. All rights reserved.

The Use of a Higher Order Kinematic Relationship on the Analysis of Cylindrical Composite Panels

DTIC Science & Technology

1991-12-01

form: exNl All A 12 A 16 B11 B12 B16 D nl D12 D16 E11 E12 E16 F11 F12 F16 COyI A12 A22 A6 B12 B22 B 1 D 2 D22 D26 E12 E2 2 E16 F1 2 F22 F26 0 A16 A 26...2 + 2E,,)kw,, ,., " kErWly + (kE11 + B 1 1)4f.,. + 2(kE 6 B16 )*.,x,, + (kE6 6 + B 616 ) *X,yy + (kE 1 6 + B 1 6 ) *y,, + [k (E1 2 + E6 6 ) " B12...B1 6 ) *x, y " (kE1 6 + B1 6 ) 1Y~ + (kE31 2 + B12) p,y, + -R-- 1 O 2 - B16 o, x + 12 W- 16W y- kF12 W, y - Wk16 + D6 x x-a W k 12 + D1 2)4r,y, 0 auo

Nature Conservancy of Canada (NCC)--Manitoba Region's Environmental Education Program

ERIC Educational Resources Information Center

Shaluk, Cathy

2007-01-01

The Nature Conservancy of Canada (NCC) is excited and proud to offer its first ever in-class education programs on the Tall Grass Prairie Ecosystem. These curriculum-based programs are offered to students from Kindergarten through to Grade 12. This experience gives many students who may never have the opportunity to visit a real live prairie to…

Validation of thigh-based accelerometer estimates of postural allocation in 5-12 year-olds.

PubMed

van Loo, Christiana M T; Okely, Anthony D; Batterham, Marijka J; Hinkley, Trina; Ekelund, Ulf; Brage, Søren; Reilly, John J; Jones, Rachel A; Janssen, Xanne; Cliff, Dylan P

2017-03-01

To validate activPAL3™ (AP3) for classifying postural allocation, estimating time spent in postures and examining the number of breaks in sedentary behaviour (SB) in 5-12 year-olds. Laboratory-based validation study. Fifty-seven children completed 15 sedentary, light- and moderate-to-vigorous intensity activities. Direct observation (DO) was used as the criterion measure. The accuracy of AP3 was examined using a confusion matrix, equivalence testing, Bland-Altman procedures and a paired t-test for 5-8y and 9-12y. Sensitivity of AP3 was 86.8%, 82.5% and 85.3% for sitting/lying, standing, and stepping, respectively, in 5-8y and 95.3%, 81.5% and 85.1%, respectively, in 9-12y. Time estimates of AP3 were equivalent to DO for sitting/lying in 9-12y and stepping in all ages, but not for sitting/lying in 5-12y and standing in all ages. Underestimation of sitting/lying time was smaller in 9-12y (1.4%, limits of agreement [LoA]: -13.8 to 11.1%) compared to 5-8y (12.6%, LoA: -39.8 to 14.7%). Underestimation for stepping time was small (5-8y: 6.5%, LoA: -18.3 to 5.3%; 9-12y: 7.6%, LoA: -16.8 to 1.6%). Considerable overestimation was found for standing (5-8y: 36.8%, LoA: -16.3 to 89.8%; 9-12y: 19.3%, LoA: -1.6 to 36.9%). SB breaks were significantly overestimated (5-8y: 53.2%, 9-12y: 28.3%, p<0.001). AP3 showed acceptable accuracy for classifying postures, however estimates of time spent standing were consistently overestimated and individual error was considerable. Estimates of sitting/lying were more accurate for 9-12y. Stepping time was accurately estimated for all ages. SB breaks were significantly overestimated, although the absolute difference was larger in 5-8y. Surveillance applications of AP3 would be acceptable, however, individual level applications might be less accurate. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

40 CFR 721.3025 - Fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (generic).

Code of Federal Regulations, 2010 CFR

2010-07-01

..., C12-18 alkyl esters (generic). 721.3025 Section 721.3025 Protection of Environment ENVIRONMENTAL... communication program. A significant new use of these substances is any manner or method of manufacture, import, or processing associated with any use of these substances without providing risk notification as...

Safety and Tolerability of Transitioning from Cangrelor to Ticagrelor in Patients Who Underwent Percutaneous Coronary Intervention.

PubMed

Badreldin, Hisham A; Carter, Danielle; Cook, Bryan M; Qamar, Arman; Vaduganathan, Muthiah; Bhatt, Deepak L

2017-08-01

The 3 phase 3 CHAMPION (Cangrelor vs Standard Therapy to Achieve Optimal Management of Platelet Inhibition) trials collectively demonstrated the safety of transitioning from cangrelor, a potent, parenteral rapidly-acting P2Y 12 inhibitor, to clopidogrel in patients who underwent percutaneous coronary intervention (PCI). However, variation in timing of therapy, site-specific binding, and drug half-lives may theoretically complicate switching to other oral P2Y 12 inhibitors. Since regulatory approval, limited data are available regarding the "real-world" safety and tolerability of transitioning to these more potent oral P2Y 12 antagonists. From November 2015 to January 2017, we evaluated the clinical profiles and efficacy and safety outcomes in cangrelor-treated patients who underwent PCI transitioned to clopidogrel (n = 42) or ticagrelor (n = 82) at a large, tertiary care center. Most patients receiving cangrelor underwent PCI with a drug-eluting stent for acute coronary syndrome via a radial approach in the background of unfractionated heparin. Stent thrombosis within 48 hours was rare and occurred in 1 patient treated with ticagrelor. Global Use of Strategies to Open Occluded Coronary Arteries-defined bleeding occurred in 20% of patients switched to ticagrelor and 29% of patients switched to clopidogrel, but none were severe or life-threatening. In conclusion, rates of stent thrombosis and severe/life-threatening bleeding were low and comparable with those identified in the CHAMPION program, despite use of more potent oral P2Y 12 inhibition. Copyright © 2017 Elsevier Inc. All rights reserved.

Calendar year 1996 annual groundwater monitoring report for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-02-01

This annual monitoring report contains groundwater and surface water monitoring data obtained in the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime) during calendar year (CY) 1996. The Chestnut Ridge Regime encompasses a section of Chestnut Ridge west of Scarboro Road and east of an unnamed drainage feature southwest of the US Department of Energy (DOE) Oak Ridge Y-12 Plant (unless otherwise noted, directions are in reference to the Y-12 Plant administrative grid). The Chestnut Ridge Regime contains several sites used for management of hazardous and nonhazardous wastes associated with plant operations. Groundwater and surface water quality monitoring associated with thesemore » waste management sites is performed under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). Included in this annual monitoring report are the groundwater monitoring data obtained in compliance with the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit for the Chestnut Ridge Regime (post-closure permit) issued by the Tennessee Department of Environment and Conservation (TDEC) in June 1996. Besides the signed certification statement and the RCRA facility information summarized below, condition II.C.6 of the post-closure permit requires annual reporting of groundwater monitoring activities, inclusive of the analytical data and results of applicable data evaluations, performed at three RCRA hazardous waste treatment, storage, or disposal (TSD) units: the Chestnut Ridge Sediment Disposal Basin (Sediment Disposal Basin), the Chestnut Ridge Security Pits (Security Pits), and Kerr Hollow Quarry.« less

Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry

PubMed Central

2010-01-01

Background Accurate identification is necessary to discriminate harmless environmental Yersinia species from the food-borne pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis and from the group A bioterrorism plague agent Yersinia pestis. In order to circumvent the limitations of current phenotypic and PCR-based identification methods, we aimed to assess the usefulness of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) protein profiling for accurate and rapid identification of Yersinia species. As a first step, we built a database of 39 different Yersinia strains representing 12 different Yersinia species, including 13 Y. pestis isolates representative of the Antiqua, Medievalis and Orientalis biotypes. The organisms were deposited on the MALDI-TOF plate after appropriate ethanol-based inactivation, and a protein profile was obtained within 6 minutes for each of the Yersinia species. Results When compared with a 3,025-profile database, every Yersinia species yielded a unique protein profile and was unambiguously identified. In the second step of analysis, environmental and clinical isolates of Y. pestis (n = 2) and Y. enterocolitica (n = 11) were compared to the database and correctly identified. In particular, Y. pestis was unambiguously identified at the species level, and MALDI-TOF was able to successfully differentiate the three biotypes. Conclusion These data indicate that MALDI-TOF can be used as a rapid and accurate first-line method for the identification of Yersinia isolates. PMID:21073689

Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.

PubMed

Ayyadurai, Saravanan; Flaudrops, Christophe; Raoult, Didier; Drancourt, Michel

2010-11-12

Accurate identification is necessary to discriminate harmless environmental Yersinia species from the food-borne pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis and from the group A bioterrorism plague agent Yersinia pestis. In order to circumvent the limitations of current phenotypic and PCR-based identification methods, we aimed to assess the usefulness of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) protein profiling for accurate and rapid identification of Yersinia species. As a first step, we built a database of 39 different Yersinia strains representing 12 different Yersinia species, including 13 Y. pestis isolates representative of the Antiqua, Medievalis and Orientalis biotypes. The organisms were deposited on the MALDI-TOF plate after appropriate ethanol-based inactivation, and a protein profile was obtained within 6 minutes for each of the Yersinia species. When compared with a 3,025-profile database, every Yersinia species yielded a unique protein profile and was unambiguously identified. In the second step of analysis, environmental and clinical isolates of Y. pestis (n = 2) and Y. enterocolitica (n = 11) were compared to the database and correctly identified. In particular, Y. pestis was unambiguously identified at the species level, and MALDI-TOF was able to successfully differentiate the three biotypes. These data indicate that MALDI-TOF can be used as a rapid and accurate first-line method for the identification of Yersinia isolates.

National Dam Safety Program. Wappingers Falls Dam (I.D. Number N.Y. 3, D.E.C. 613A), Hudson River Basin, Dutchess County, New York. Phase 1 Inspection Report

DTIC Science & Technology

1980-09-30

Classification 2I e. Ownership 2f. Purpose of Dam 2 g. Design and Construction History 2h. Normal Operating Procedure 2 1.3 PERTINENT DATA 2 a. Drainage...4 2.2 SUBSURFACE INVESTIGATION 4 2.3 DAM AND APPURTENANT STRUCTURES 4 2.4 CONSTRUCTION RECORDS 4 2.5 OPERATION RECORDS 2.6 EVALUATION OF DATA 5 4...12 a. Visual Observations 12 b. Design and Construction Data 12 c. Stability Analysis 12 d. Operating Records 13 e. Post- Construction Changes 13 f

Algunas Premisas Metodologicas y Conceptuales sobre el Desarrollo de los Movimientos en el Primer Ano de Vida (0-12 Meses) (Some Methodological and Conceptual Premises about the Development of Movement in the First Year of Life (0-12 Months)).

ERIC Educational Resources Information Center

Bequer Diaz, Gladys

1997-01-01

Examined the emergence of principal and secondary movements in Cuban children in their first year of life. Based on 35 examples of observed movements, an integrated program of activity is developed to assist in the development of physical skills which are essential to the development of a well-rounded personality. (AS)

Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.

PubMed

Chang, Hung; Yanachkov, Ivan B; Michelson, Alan D; Li, YouFu; Barnard, M R; Wright, George E; Frelinger, Andrew L

2010-02-01

Diadenosine 5',5'''-P(1),P(4)- tetraphosphate (Ap(4)A) is stored in platelet dense granules, but its effects on platelet function are not well understood. We examined the effects of Ap(4)A on platelet purinergic receptors P2Y(1), P2Y(12) and P2X(1). Flow cytometry was used to measure the effects of Ap(4)A in the presence or absence of ADP on: a) P2Y(12)-mediated decrease in intraplatelet phosphorylated vasodilator stimulated phosphoprotein (VASP), b) P2Y(1)-mediated increase in platelet cytosolic Ca(2+), and c) P2X(1)-mediated intraplatelet entry of extracellular Ca(2+). ADP-stimulated platelet shape change (P2Y(1)-mediated) and aggregation (P2Y(1)- and P2Y(12)-mediated) were measured optically. Ap(4)A inhibited 3 microM ADP-induced: a) platelet aggregation (IC(50) 9.8+/-2.8 microM), b) P2Y(1)-mediated shape change, c) P2Y(1)-mediated increase in platelet cytosolic Ca(2+) (IC(50) 40.8+/-12.3 microM), and d) P2Y(12)-mediated decrease in VASP phosphorylation (IC(50)>250 microM). In the absence of added ADP, Ap(4)A had agonist effects on platelet P2X(1) and P2Y(12), but not P2Y(1), receptors. Ap(4)A, a constituent of platelet dense granules, is a) an antagonist of platelet P2Y(1) and P2Y(12) receptors, where it inhibits the effects of ADP, and b) an agonist of platelet P2X(1) and P2Y(12) receptors. Copyright 2009 Elsevier Ltd. All rights reserved.

Agonist and Antagonist Effects of Diadenosine Tetraphosphate, a Platelet Dense Granule Constituent, on Platelet P2Y1, P2Y12 and P2X1 Receptors

PubMed Central

Chang, Hung; Yanachkov, Ivan B.; Michelson, Alan D.; Li, YouFu; Barnard, M.R.; Wright, George E.; Frelinger, Andrew L.

2010-01-01

Introduction Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) is stored in platelet dense granules, but its effects on platelet function are not well understood. Methods and Results We examined the effects of Ap4A on platelet purinergic receptors P2Y1, P2Y12 and P2X1. Flow cytometry was used to measure the effects of Ap4A in the presence or absence of ADP on: a) P2Y12-mediated decrease in intraplatelet phosphorylated vasodilator stimulated phosphoprotein (VASP), b) P2Y1-mediated increase in platelet cytosolic Ca2+, and c) P2X1-mediated intraplatelet entry of extracellular Ca2+. ADP-stimulated platelet shape change (P2Y1-mediated) and aggregation (P2Y1- and P2Y12-mediated) were measured optically. Ap4A inhibited 3 µM ADP-induced: a) platelet aggregation (IC50 9.8 ± 2.8 µM), b) P2Y1-mediated shape change, c) P2Y1-mediated increase in platelet cytosolic Ca2+ (IC50 40.8 ± 12.3 µM), and d) P2Y12-mediated decrease in VASP phosphorylation (IC50 >250 µM). In the absence of added ADP, Ap4A had agonist effects on platelet P2X1 and P2Y12, but not P2Y1, receptors. Conclusion Ap4A, a constituent of platelet dense granules, is a) an antagonist of platelet P2Y1 and P2Y12 receptors, where it inhibits the effects of ADP, and b) an agonist of platelet P2X1 and P2Y12 receptors. PMID:19945153

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

PubMed Central

André, Patrick; Delaney, Suzanne M.; LaRocca, Thomas; Vincent, Diana; DeGuzman, Francis; Jurek, Marzena; Koller, Beverley; Phillips, David R.; Conley, Pamela B.

2003-01-01

The critical role for ADP in arterial thrombogenesis was established by the clinical success of P2Y12 antagonists, currently used at doses that block 40–50% of the P2Y12 on platelets. This study was designed to determine the role of P2Y12 in platelet thrombosis and how its complete absence affects the thrombotic process. P2Y12-null mice were generated by a gene-targeting strategy. Using an in vivo mesenteric artery injury model and real-time continuous analysis of the thrombotic process, we observed that the time for appearance of first thrombus was delayed and that only small, unstable thrombi formed in P2Y12–/– mice without reaching occlusive size, in the absence of aspirin. Platelet adhesion to vWF was impaired in P2Y12–/– platelets. While adhesion to fibrinogen and collagen appeared normal, the platelets in thrombi from P2Y12–/– mice on collagen were less dense and less activated than their WT counterparts. P2Y12–/– platelet activation was also reduced in response to ADP or a PAR-4–activating peptide. Thus, P2Y12 is involved in several key steps of thrombosis: platelet adhesion/activation, thrombus growth, and stability. The data suggest that more aggressive strategies of P2Y12 antagonism will be antithrombotic without the requirement of aspirin cotherapy and may provide benefits even to the aspirin-nonresponder population. PMID:12897207

40 CFR 52.1519 - Identification of plan-conditional approval.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1519... specified. (1) On January 12, 1993, the New Hampshire Department of Environmental Services submitted a small..., 1994, New Hampshire submitted a letter deleting portions of the January 12, 1993 submittal. In these...

40 CFR 52.1519 - Identification of plan-conditional approval.

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New Hampshire § 52.1519... specified. (1) On January 12, 1993, the New Hampshire Department of Environmental Services submitted a small..., 1994, New Hampshire submitted a letter deleting portions of the January 12, 1993 submittal. In these...

Weight Outcomes of Latino Adults and Children Participating in the Y Living Program, a Family-Focused Lifestyle Intervention, San Antonio, 2012-2013.

PubMed

Parra-Medina, Deborah; Liang, Yuanyuan; Yin, Zenong; Esparza, Laura; Lopez, Louis

2015-12-10

US Latinos have disproportionately higher rates of obesity and physical inactivity than the general US population, putting them at greater risk for chronic disease. This evaluation aimed to examine the impact of the Y Living Program (Y Living), a 12-week family-focused healthy lifestyle program, on the weight status of adult and child (aged ≥7 years) participants. In this pretest-posttest evaluation, participants attended twice-weekly group education sessions and engaged in physical activity at least 3 times per week. Primary outcome measures were body mass index ([BMI], zBMI and BMI percentile for children), weight, waist circumference, and percentage body fat. Wilcoxon signed-rank tests and mixed effects models were used to evaluate pretest-posttest differences (ie, absolute change and relative change) for adults and children separately. BMI, weight, waist circumference, and percentage body fat improved significantly (both absolutely and relatively) among adults who completed the program (n = 180; all P ≤ .001). Conversely, child participants that completed the program (n = 72) showed no improvements. Intervention effects varied across subgroups. Among adults, women and participants who were obese at baseline had larger improvements than did children who were obese at baseline or who were in families that had an annual household income of $15,000 or more. Significant improvements in weight were observed among adult participants but not children. This family-focused intervention has potential to prevent excess weight gain among high-risk Latino families.

Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 1. Air Force Plant 6, Cobb County, Georgia. Volume 3.

DTIC Science & Technology

1986-08-09

WATER ASSESSMENT PROGRAM AIR FOsEa PLANT 6, L0CKED-GEOCIA CONPANY MARIETTA, GMO IA PROJECT NO. 611059 WELL 4W-22 WELL 4W-23 WELL MW-24 WELL 4W-25 Dace...PROGRAMo PHASE II--CONFIRMATION/QUANTIFICATION 0STAGE I Final Report for AIR FORCE PLANT 6, COBB COUNTY, GA. U.S. AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL...Con uet on reverse 4 necessary arc .entir’y ay )lcx "UrCer) I;;EL_0 GROUP I SUB-GROuP Air Force Plant , Hazardous materialsI oilS’ DeB Ground water, S

Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation

PubMed Central

CHANG, H.; YANACHKOV, I. B.; DIX, E. J.; LI, Y. F.; BARNARD, M. R.; WRIGHT, G. E.; MICHELSON, A. D.; FRELINGER, A. L.

2017-01-01

Summary Background Diadenosine 5′,5‴-P1,P4-tetraphosphate (Ap4A), a natural compound stored in platelet dense granules, inhibits ADP-induced platelet aggregation. Ap4A inhibits the platelet ADP receptors P2Y1 and P2Y12, is a partial agonist of P2Y12, and is a full agonist of the platelet ATP-gated ion channel P2X1. Modification of the Ap4A tetraphosphate backbone enhances inhibition of ADP-induced platelet aggregation. However, the effects of these Ap4A analogs on human platelet P2Y1, P2Y12 and P2X1 are unclear. Objective To determine the agonist and antagonist activities of diadenosine tetraphosphate analogs towards P2Y1, P2Y12, and P2X1. Methods We synthesized the following Ap4A analogs: P1,P4-dithiotetraphosphate; P2,P3-chloromethylenetetraphosphate; P1-thio-P2,P3-chloromethylenetetraphosphate; and P1,P4-dithio-P2,P3-chloromethylenetetraphosphate. We then measured the effects of these analogs on: (i) ADP-induced platelet aggregation; (ii) P2Y1-mediated changes in cytosolic Ca2+; (iii) P2Y12-mediated changes in vasodilator-stimulated phosphoprotein phosphorylation; and (iv) P2X1-mediated entry of extracellular Ca2+. Results Ap4A analogs with modifications in the phosphate backbone inhibited both P2Y1 and P2Y12, and showed no agonist activity towards these receptors. The dithio modification increased inhibition of P2Y1, P2Y12, and platelet aggregation, whereas the chloromethylene modification increased inhibition of P2Y12 and platelet aggregation, but decreased P2Y1 inhibition. Combining the dithio and chloromethylene modifications increased P2Y1 and P2Y12 inhibition. As compared with Ap4A, each modification decreased agonist activity towards P2X1, and the dual modification completely eliminated P2X1 agonist activity. Conclusions As compared with Ap4A, tetraphosphate backbone analogs of Ap4A have diminished activity towards P2X1 but inhibit both P2Y1 and P2Y12 and, with greater potency, inhibit ADP-induced platelet aggregation. Thus, diadenosine tetraphosphate analogs with dual receptor selectivity may have potential as antiplatelet drugs. PMID:23083103

Educating Young People about Environmental Health for Informed Social Action.

PubMed

Keselman, Alla; Levin, Daniel M; Kramer, Judy F; Matzkin, Karen; Dutcher, Gale

2011-01-01

Whereas environmental health education is rapidly becoming a global priority, it still receives little attention in schools. This paper describes a U.S. National Library of Medicine program, aiming to support environmental health education in grades 6-12 in U.S. schools. The program has four components: (1) developing reliable online resources that provide quality environmental health information; (2) creating lesson plans that integrate our resources into the classroom and extracurricular activities; (3) engaging teachers by inviting collaborations and promoting our resources and activities; and (4) conducting educational research that provides a foundation for the other components. The paper describes specific educational resources and activities and grounds them in learning theories from the fields of cognitive psychology and science education.

Educating Young People about Environmental Health for Informed Social Action

PubMed Central

Keselman, Alla; Levin, Daniel M.; Kramer, Judy F.; Matzkin, Karen; Dutcher, Gale

2013-01-01

Whereas environmental health education is rapidly becoming a global priority, it still receives little attention in schools. This paper describes a U.S. National Library of Medicine program, aiming to support environmental health education in grades 6-12 in U.S. schools. The program has four components: (1) developing reliable online resources that provide quality environmental health information; (2) creating lesson plans that integrate our resources into the classroom and extracurricular activities; (3) engaging teachers by inviting collaborations and promoting our resources and activities; and (4) conducting educational research that provides a foundation for the other components. The paper describes specific educational resources and activities and grounds them in learning theories from the fields of cognitive psychology and science education. PMID:24383062

12 CFR Appendix F to Part 225 - Interagency Guidelines Establishing Information Security Standards

Code of Federal Regulations, 2011 CFR

2011-01-01

... arrangements in place to control risks. C. Manage and Control Risk. Each bank holding company shall: 1. Design... GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Pt.... Assess Risk C. Manage and Control Risk D. Oversee Service Provider Arrangements E. Adjust the Program F...

Iron, zinc, folate, and vitamin B12 status increased among women and children in Yaounde and Douala, Cameroon, one year after introducing fortified wheat flour

USDA-ARS?s Scientific Manuscript database

Background: Few data, to our knowledge, are available on the effectiveness of large-scale food fortification programs. Objective: We assessed the impact of mandatory wheat flour fortification on micronutrient status in Yaounde and Douala, Cameroon. Methods: We conducted representative surveys 2 y ...

Technical and Regulatory Guidance for Surfactant/Cosolvent Flushing of DNAPL Source Zones

DTIC Science & Technology

2003-04-01

industry and public institutions who contributed to this document: George J . Hall – ITRC Program Advisor Doug Beal – BEM Systems Susan Gawarecki...these tests are also used during the design process to estimate hydraulic properties based on empirical correlations ( Vukovic and Soro, 1992). Samples...Journal of Environmental Engineering, 124(6): 498–503. Bear, J . 1972. Flow Through Porous Media. Elsevier, N.Y. Bedient, P.B., A.W. Holder, C.G

Central Radar System, Over-the-Horizon Backscatter

DTIC Science & Technology

1990-03-09

1,2-Dibromo-3- chloropropane (DBCP) 0.3 TABLE 41-6 (Continued). MINNESOTA RECOMMENDED ALLOWABLE LIMITS (RAL) FOR DRINKING WATER WELLS Compound RAL (ug/ 1 ...TABLE OF CONTENTS ENVIRONMENTAL IMPACT ANALYSIS PROCESS OVERVIEW ............ TECHNICAL STUDY 1 FACILITIES...TECHNICAL STUDY 10 0 TECHNICAL STUDY 1 CENTRAL RADAR SYSTEM OVER-THE-HORIZON BACKSCATTER RADAR PROGRAM 0 ENVIRONMENTAL IMPACT

Environmental Education as Teacher Education: Melancholic Reflections from an Emerging Community of Practice

ERIC Educational Resources Information Center

Ormond, Carlos; Zandvliet, David; McClaren, Milton; Robertson, Patrick; Leddy, Shannon; Metcalfe, Selina

2014-01-01

During 2011 at Simon Fraser University, the Faculty of Education hosted the implementation of a pre-service teacher education program with an emphasis on sustainability and environmental learning. This cohort, termed SEEDs (Sustainability Education in an Environment of Diversity), enrolled 32 teacher education students in an intensive 12-month…

Environmental restoration and waste management: An introduction. Student edition; Restauracion ambiental y administracion de residuos nucleares: Introduccion; Edicion estudiantil (in Spanish)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

For more than 40 years, the United States has produced nuclear weapons. These production activities generated both radioactive and hazardous waste and often contaminated the environment. For many years, the public was unaware of the problem and unable to do anything about it. All of this has changed. In response to recent public outcry, the former Secretary of Energy, Retired Admiral James D. Watkins, established the Office of Environmental Restoration and Waste Management (EM) in November 1989. The creation of EM was the first step toward correcting contamination problems from the past 40 years In this booklet, we at DOE,more » through the efforts of the students at Oak Hills High School of Cincinnati, Ohio, will introduce you to EM and encourage your involvement in this major program within the Department of Energy. [Espanol] Durante mas de 40 anos, los Estados Unidos fabricaron armamentos nucleares. Esta produccion genero residuos radiactivos y peligrosos y, en muchos casos, contaminaron el medio ambiente. Durante mucho tiempo, el publico norteamericano no tenia conocimiento de este problema y no pudo hacer nada para solucionarlo. Todo esto ha cambiado. Respondiendo a crecientes protestas publicas, el ex Secretario de Energia Almirante James D. Watkins, establecio en noviembre de 1989 la Subsecretaria de Administracion Ambiental. La creacion de esta Subsecretaria fue el primer paso que dio el Departamento de Energia para corregir los problemas de contaminacion ambiental de los ultimos 40 anos. En esta publicacion, los que trabajamos en el Departamento de Energia con la ayuda de los estudiantes de la Escuela Secundaria de Oak Hills, Cincinnati, Ohio, te introduciermos a la administracion ambiental y alentamos tu participacion en este programa de fundamental importancia en el Departamento de Energia.« less

Study of third order nonlinearity of chalcogenide thin films using third harmonic generation measurements

NASA Astrophysics Data System (ADS)

Rani, Sunita; Mohan, Devendra; Kumar, Manish; Sanjay

2018-05-01

Third order nonlinear susceptibility of (GeSe3.5)100-xBix (x = 0, 10, 14) and ZnxSySe100-x-y (x = 2, y = 28; x = 4, y = 20; x = 6, y = 12; x = 8, y = 4) amorphous chalcogenide thin films prepared using thermal evaporation technique is estimated. The dielectric constant at incident and third harmonic wavelength is calculated using "PARAV" computer program. 1064 nm wavelength of Nd: YAG laser is incident on thin film and third harmonic signal at 355 nm wavelength alongwith fundamental light is obtained in reflection that is separated from 1064 nm using suitable optical filter. Reflected third harmonic signal is measured to trace the influence of Bi and Zn on third order nonlinear susceptibility and is found to increase with increase in Bi and Zn content in (GeSe3.5)100-xBix, and ZnxSySe100-x-y chalcogenide thin films respectively. The excellent optical nonlinear property shows the use of chalcogenide thin films in photonics for wavelength conversion and optical data processing.

A longitudinal medical Spanish program at one US medical school.

PubMed

Reuland, Daniel S; Frasier, Pamela Y; Slatt, Lisa M; Alemán, Marco A

2008-07-01

Policymakers have recommended recruiting or training (or both) more US physicians who can provide care in Spanish. Few longitudinal medical Spanish programs have been described and evaluated. This study aims to describe development and evaluation of the preclinical phase of a 4-y program designed to graduate physicians who can provide language-concordant care in Spanish. Study was done in one public medical school in southeastern USA. The program targeted intermediate/advanced Spanish speakers. Standardized fluency assessments were used to determine eligibility and evaluate participants' progress. Curriculum included didactic coursework, simulated patients, socio-cultural seminars, clinical skills rotations at sites serving Latinos, service-learning, and international immersion. For the first two cohorts (n = 45) qualitative evaluation identified program improvement opportunities and found participants believed the program helped them maintain their Spanish skills. Mean interim (2-y) speaking proficiency scores were unchanged from baseline: 9.0 versus 8.7 at baseline on 12-point scale (p = 0.15). Mean interim listening comprehension scores (second cohort only, n = 25) increased from a baseline of 77 to 86% (p = 0.003). Proportions "passing" the listening comprehension test increased from 72 to 92% (p = 0.06). We describe development of a longitudinal Spanish program within a medical school. Participation was associated with improved Spanish listening comprehension and no change in speaking proficiency.

Identification of Determinants Required for Agonistic and Inverse Agonistic Ligand Properties at the ADP Receptor P2Y12

PubMed Central

Schmidt, Philipp; Ritscher, Lars; Dong, Elizabeth N.; Hermsdorf, Thomas; Cöster, Maxi; Wittkopf, Doreen; Meiler, Jens

2013-01-01

The ADP receptor P2Y12 belongs to the superfamily of G protein–coupled receptors (GPCRs), and its activation triggers platelet aggregation. Therefore, potent antagonists, such as clopidogrel, are of high clinical relevance in prophylaxis and treatment of thromboembolic events. P2Y12 displays an elevated basal activity in vitro, and as such, inverse agonists may be therapeutically beneficial compared with antagonists. Only a few inverse agonists of P2Y12 have been described. To expand this limited chemical space and improve understanding of structural determinants of inverse agonist-receptor interaction, this study screened a purine compound library for lead structures using wild-type (WT) human P2Y12 and 28 constitutively active mutants. Results showed that ATP and ATP derivatives are agonists at P2Y12. The potency at P2Y12 was 2-(methylthio)-ADP > 2-(methylthio)-ATP > ADP > ATP. Determinants required for agonistic ligand activity were identified. Molecular docking studies revealed a binding pocket for the ATP derivatives that is bordered by transmembrane helices 3, 5, 6, and 7 in human P2Y12, with Y105, E188, R256, Y259, and K280 playing a particularly important role in ligand interaction. N-Methyl-anthraniloyl modification at the 3′-OH of the 2′-deoxyribose leads to ligands (mant-deoxy-ATP [dATP], mant-deoxy-ADP) with inverse agonist activity. Inverse agonist activity of mant-dATP was found at the WT human P2Y12 and half of the constitutive active P2Y12 mutants. This study showed that, in addition to ADP and ATP, other ATP derivatives are not only ligands of P2Y12 but also agonists. Modification of the ribose within ATP can result in inverse activity of ATP-derived ligands. PMID:23093496

Japanese Language and Culture: 10-3Y, 20-3Y, 30-3Y. 3-Year Program Guide to Implementation

ERIC Educational Resources Information Center

Alberta Education, 2009

2009-01-01

This guide to implementation is intended to support the Japanese Language and Culture 10-3Y, 20-3Y, 30-3Y Program of Studies. It was developed primarily for teachers, yet it includes information that may be useful for administrators and other stakeholders in their efforts to plan for and implement the new Japanese program of studies. Familiarity…

A Review of Models of the Human Temperature Regulation System.

DTIC Science & Technology

1992-02-18

experiments to challenge the model and building new models, the researcher will benefit cptimally from its use. It appears that this process has been...during Cooling OUTPUTS: WWe W, Decreased by ?. W H~eating .. ___ > - W Constnt during Coolng IT OUTPUTS: U Increased by 7 We Haoling and Coaling Y. L.AT,)0...12, pp. 709-903, 1976. 43. Slonim, N.B., Environmental Physiology, Mosby, St.Louis, MO, 1974. 44. Sulman, S.G., Health , Weather, and Climate, Karger

Report on the remedial investigation of Bear Creek Valley at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Volume 3: Appendix D -- Nature and extent of contamination report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-09-01

This Remedial Investigation (RI) Report characterizes the nature and extent of contamination, evaluates the fate and transport of contaminants, and assesses risk to human health and the environment resulting from waste disposal and other US Department of Energy (DOE) operations in Bear Creek Valley (BCV). BCV, which is located within the DOE Oak Ridge Reservation (ORR) encompasses multiple waste units containing hazardous and radioactive wastes arising from operations at the adjacent Oak Ridge Y-12 Plant. The primary waste units discussed in this RI Report are the S-3 Site, Oil Landfarm (OLF), Boneyard/Burnyard (BYBY), Sanitary Landfill 1 (SL 1), and Bearmore » Creek Burial Grounds (BCBG). These waste units, plus the contaminated media resulting from environmental transport of the wastes from these units, are the subject of this RI. This BCV RI Report represents the first major step in the decision-making process for the BCV watershed. The RI results, in concert with the follow-on FS will form the basis for the Proposed Plan and Record of Decision for all BCV sites. This comprehensive decision document process will meet the objectives of the watershed approach for BCV. Appendix D describes the nature and extent of contamination in environmental media and wastes.« less

Differential endosomal sorting of a novel P2Y12 purinoreceptor mutant.

PubMed

Cunningham, Margaret R; Nisar, Shaista P; Cooke, Alexandra E; Emery, Elizabeth D; Mundell, Stuart J

2013-05-01

P2Y12 receptor internalization and recycling play an essential role in ADP-induced platelet activation. Recently, we identified a patient with a mild bleeding disorder carrying a heterozygous mutation of P2Y12 (P341A) whose P2Y12 receptor recycling was significantly compromised. Using human cell line models, we identified key proteins regulating wild-type (WT) P2Y12 recycling and investigated P2Y12 -P341A receptor traffic. Treatment with ADP resulted in delayed Rab5-dependent internalization of P341A when compared with WT P2Y12 . While WT P2Y12 rapidly recycled back to the membrane via Rab4 and Rab11 recycling pathways, limited P341A recycling was observed, which relied upon Rab11 activity. Although minimal receptor degradation was evident, P341A was localized in Rab7-positive endosomes with considerable agonist-dependent accumulation in the trans-Golgi network (TGN). Rab7 activity is known to facilitate recruitment of retromer complex proteins to endosomes to transport cargo to the TGN. Here, we identified that P341A colocalized with Vps26; depletion of which blocked limited recycling and promoted receptor degradation. This study has identified key points of divergence in the endocytic traffic of P341A versus WT-P2Y12 . Given that these pathways are retained in human platelets, this research helps define the molecular mechanisms regulating P2Y12 receptor traffic and explain the compromised receptor function in the platelets of the P2Y12 -P341A-expressing patient. © 2013 John Wiley & Sons A/S.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) persistence in the Seveso (Milan, Italy) soil.

PubMed

Cerlesi, S; Di Domenico, A; Ratti, S

1989-10-01

Preliminary results of a new study on TCDD environmental persistence at Seveso (Milan, Italy) are presented. For this study, the most contaminated territory, Zone A, was divided into areas to fractionate the available TCDD levels in soil into data sets with reduced value spreads. In addition, various time subsets were defined for each area. Selected data were fitted with the exponential model y = y0.e-k.1. It was estimated that at least 1.2 kg TCDD was present in Zone A shortly after the accident. On average, a considerable portion (23%) of this amount lay on vegetation; TCDD which was not photodegraded or volatilized before the heavy rains of fall 1976, was later washed off and transferred to ground by water action. From this study, mean analytical underestimations affecting January 1977 and March 1978 contamination map data were on the order of 30 and 24%. All the above figures are considered optimistic. A few years after the accident, mean TCDD half-life in soil appeared to be 9.1y (t1/2-95% CLs, 6.2-17y).

Disneyland resort's environmentality'' program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohel, M.E.

Today at Disneyland Resort more than 12,000 Cast Members (employees) have pledged to think and act environmentally. The Environmental Affairs Department and the environmentality logo were established about 2-1/2 years ago to promote environmental awareness throughout the company. In 1993, a new campaign stressing recycling took place. Cast members were asked to pledge to recycle plastic containers. The goal was to raise their awareness of various grades of recyclable plastic. In turn, they received a T-shirt made from 50% recycled plastic (from The Walt Disney Company) and 50% virgin plastic.

Optimum Aeroelastic Characteristics for Composite Supermaneuverable Aircraft.

DTIC Science & Technology

1986-07-31

1󈨌D22 1 k 16 ’ cD 22YI Y6 WL k 17 ’ cD 22 Y, Y7 k 18 ’ -2cD 26YI1 Y6 gi 0 k19 : -2cD26Y I y 7 k1,10 12 2c Bo 10 1 󈧐D22 1 10 22 cD22 (y2 )2 k23 -2cD...2 6y1Y2 k24 -2cD 2 6 Y2Y 2 3 ,, 11 10 k -S-D + 2cD a 25 12 D22 5 2 12 5 2 k26 cD22 Y2 Y6 k27 cD22 y2 Y7 28 -2cD 2 6 Y2 Y6 k29 -2cD 26Y2 Y7 k’ "" 0y

Resident Perceptions of 2-Year Versus 3-Year Cardiothoracic Training Programs.

PubMed

Nguyen, Tom C; Terwelp, Matthew D; Stephens, Elizabeth H; Odell, David D; Loor, Gabriel; LaPar, Damien J; DeNino, Walter F; Wei, Benjamin; Aftab, Muhammad; Macke, Ryan A; Nelson, Jennifer S; Berfield, Kathleen S; Lazar, John F; Stein, William; Youssef, Samuel J; Tchantchaleishvili, Vakhtang

2015-06-01

Resident perceptions of 2-year (2Y) vs 3-year (3Y) programs have never been characterized. The objective was to use the mandatory Thoracic Surgery Residents Association and Thoracic Surgery Directors Association In-Training Examination survey to compare perceptions of residents graduating from 2Y vs 3Y cardiothoracic programs. Each year Accreditation Council for Graduate Medical Education cardiothoracic residents are required to take a 30-question survey designed by the Thoracic Surgery Residents Association and the Thoracic Surgery Directors Association accompanying the In-Training Examination with a 100% response rate. The 2013 and 2014 survey responses of residents graduating from 2Y vs 3Y training programs were compared. The Wilcoxon signed rank test was used to analyze ordinal and interval data. Graduating residents completed 167 surveys, including 96 from 2Y (56%) and 71 from 3Y (43%) programs. There was no difference in the perception of being prepared for the American Board of Thoracic Surgery examinations or amount of debt between 2Y and 3Y respondents. There was no difference in intended academic vs private practice. Graduating 3Y residents felt more prepared to meet case requirements and better trained, were more likely to pass their written American Board of Thoracic Surgery examinations, and were less likely to pursue additional training beyond their cardiothoracic residency. There was no difference in field of interest, practice type, and amount of debt between graduating 2Y vs 3Y residents. Respondents from 2Y programs expressed more difficulty in meeting case requirements, whereas residents from 3Y programs felt more prepared for independent practice and had higher American Board of Thoracic Surgery written pass rates. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Permeability and storage ability of inorganic X12Y12 fullerenes for lithium atom and ion

NASA Astrophysics Data System (ADS)

Munsif, Sajida; Ayub, Khurshid

2018-04-01

In the current study, permeability and storage ability (exohedral and endohedral) of inorganic fullerenes X12Y12 (X = B, Al and Y = N, P) for lithium atom/ion (Li/Li+) is studied theoretically at M05-2X method. The translation of Li/Li+ through Al12P12 nano-cages is not only a kinetically feasible process but also has very high separation ratio in the favor of lithium atom over lithium ion. Adsorption/encapsulation energies of alkali metal on/in nano-cages show strong correlation with the size of the nano-cage. The percent changes in H-L gap for Li+-X12Y12 are about 1-25%, whereas the corresponding changes for Li-X12Y12 are 30-72%.

Physical activity and relaxation in the work setting to reduce the need for recovery: what works for whom?

PubMed

Formanoy, Margriet A G; Dusseldorp, Elise; Coffeng, Jennifer K; Van Mechelen, Iven; Boot, Cecile R L; Hendriksen, Ingrid J M; Tak, Erwin C P M

2016-08-24

To recover from work stress, a worksite health program aimed at improving physical activity and relaxation may be valuable. However, not every program is effective for all participants, as would be expected within a "one size fits all" approach. The effectiveness of how the program is delivered may differ across individuals. The aim of this study was to identify subgroups for whom one intervention may be better suited than another by using a new method called QUalitative INteraction Trees (QUINT). Data were used from the "Be Active & Relax" study, in which 329 office workers participated. Two delivery modes of a worksite health program were given, a social environmental intervention (group motivational interviewing delivered by team leaders) and a physical environmental intervention (environmental modifications). The main outcome was change in Need for Recovery (NFR) from baseline to 12 month follow-up. The QUINT method was used to identify subgroups that benefitted more from either type of delivery mode, by incorporating moderator variables concerning sociodemographic, health, home, and work-related characteristics of the participants. The mean improvement in NFR of younger office workers in the social environmental intervention group was significantly higher than younger office workers who did not receive the social environmental intervention (10.52; 95 % CI: 4.12, 16.92). Furthermore, the mean improvement in NFR of older office workers in the social environmental intervention group was significantly lower than older office workers who did not receive the social environmental intervention ( -10.65; 95 % CI: -19.35, -1.96). The results for the physical environmental intervention indicated that the mean improvement in NFR of office workers (regardless of age) who worked fewer hours overtime was significantly higher when they had received the physical environmental intervention than when they had not received this type of intervention (7.40; 95 % CI: 0.99, 13.81). Finally, for office workers who worked more hours overtime there was no effect of the physical environmental intervention. The results suggest that a social environmental intervention might be more beneficial for younger workers, and a physical environmental intervention might be more beneficial for employees with a few hours overtime to reduce the NFR. NTR2553.

High quality Y-type hexaferrite thick films for microwave applications by an economical and environmentally benign crystal growth technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Bolin; Chen, Yajie, E-mail: y.chen@neu.edu; Gillette, Scott

2014-02-17

Thick barium hexaferrite Ba{sub 2}Zn{sub 2}Fe{sub 12}O{sub 22} (i.e., Zn{sub 2}Y) films having thicknesses of ∼100 μm were epitaxially grown on MgO (111) substrates using an environmentally benign ferrite-salt mixture by vaporizing the salt. X-ray diffraction pole figure analyses showed (00l) crystallographic alignment with little in plane dispersion confirming epitaxial growth. Saturation magnetization, 4πM{sub s}, was measured for as-grown films to be 2.51 ± 0.1 kG with an out of plane magnetic anisotropy field H{sub A} of 8.9 ± 0.1 kOe. Ferromagnetic resonance linewidth, as the peak-to-peak power absorption derivative at 9.6 GHz, was measured to be 62 Oe. These properties demonstrate a rapid, convenient, cost-effective, and nontoxic methodmore » of growing high quality thick crystalline ferrite films which could be used widely for microwave device applications.« less

Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 13: Part 1, Main text

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goins, L.F.; Webb, J.R.; Cravens, C.D.

1992-09-01

This publication contains 1035 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions. These citations constitute the thirteenth in a series of reports prepared annually for the US Department of Energy (DOE) Environmental Restoration programs. Citations to foreign and domestic literature of all types. There are 13 major sections of the publication, including: (1) DOE Decontamination and Decommissioning Program; (2) Nuclear Facilities Decommissioning; (3) DOE Formerly Utilized Sites Remedial Action Program; (4) DOE Uranium Mill Tailings Remedial Action Project; (5) Uranium Mill Tailings Management; (6) DOE Environmental Restoration Program; (7) DOE Site-Specific Remedialmore » Actions; (8) Contaminated Site Restoration; (9) Remediation of Contaminated Soil and Groundwater; (10) Environmental Data Measurements, Management, and Evaluation; (11) Remedial Action Assessment and Decision-Making; (12) Technology Development and Evaluation; and (13) Environmental and Waste Management Issues. Bibliographic references are arranged in nine subject categories by geographic location and then alphabetically by first author, corporate affiliation, or publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word.« less

The Ships Below-Decks Electromagnetic Compatibility (EMC) Program. A compilation of Papers Presented at the 1987 IEEE International Symposium on EMC

DTIC Science & Technology

1987-09-30

were producing below-deck environ - such that after 24 hours the performance loss ranged mental levels exceeding the "normal" environmental from 13 to...SGA performance environmental EMI testing in the electromagnetically measurements b- made in the laboratory. However, it quiet laboratory environments ... Environmentally Sealed SGAs.................................... 1-1 Need for Long Term SGA Performance Evaluation .................... 1-2 Performance

Organization and Operation of a K-12 Environmental Education Program. Revised.

ERIC Educational Resources Information Center

Bennett, Dean B.; Willink, Wesley H.

Environmental education is a process aimed at producing a citizenry that is knowledgeable concerning the total environment and the role of man, able to participate in activities for maintaining and improving the quality of the environment while meeting human needs and motivated to do so. This guide focuses on the organization and operation of an…

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

NASA Astrophysics Data System (ADS)

Paoletta, Silvia; Sabbadin, Davide; von Kügelgen, Ivar; Hinz, Sonja; Katritch, Vsevolod; Hoffmann, Kristina; Abdelrahman, Aliaa; Straßburger, Jens; Baqi, Younis; Zhao, Qiang; Stevens, Raymond C.; Moro, Stefano; Müller, Christa E.; Jacobson, Kenneth A.

2015-08-01

The G protein-coupled P2Y12 receptor (P2Y12R) is an important antithrombotic target and of great interest for pharmaceutical discovery. Its recently solved, highly divergent crystallographic structures in complex either with nucleotides (full or partial agonist) or with a nonnucleotide antagonist raise the question of which structure is more useful to understand ligand recognition. Therefore, we performed extensive molecular modeling studies based on these structures and mutagenesis, to predict the binding modes of major classes of P2Y12R ligands previously reported. Various nucleotide derivatives docked readily to the agonist-bound P2Y12R, but uncharged nucleotide-like antagonist ticagrelor required a hybrid receptor resembling the agonist-bound P2Y12R except for the top portion of TM6. Supervised molecular dynamics (SuMD) of ticagrelor binding indicated interactions with the extracellular regions of P2Y12R, defining possible meta-binding sites. Ureas, sulfonylureas, sulfonamides, anthraquinones and glutamic acid piperazines docked readily to the antagonist-bound P2Y12R. Docking dinucleotides at both agonist- and antagonist-bound structures suggested interactions with two P2Y12R pockets. Thus, our structure-based approach consistently rationalized the main structure-activity relationships within each ligand class, giving useful information for designing improved ligands.

Colonie Interim Storage Site annual environmental report for calendar year 1991, Colonie, New York. Formerly Utilized Sites Remedial Action Program (FUSRAP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-09-01

This document describes the environmental monitoring program at the Colonie Interim Storage Site (CISS) and surrounding area, implementation of the program, and monitoring results for 1991. Environmental monitoring at CISS began in 1984 when Congress added the site to the US Department of Energy`s Formerly Utilized Sites Remedial Action Program. CISS property and surrounding areas were radioactively contaminated by operations conducted by National Lead Industries, which manufactured various components from uranium and thorium from 1958 to 1984. The environmental monitoring program at CISS includes sampling networks for external gamma radiation exposure and for radium-226, thorium-232, and total uranium concentrations inmore » surface water, sediment, and groundwater. Additionally, several nonradiological parameters are measured in groundwater. In 1992 the program will also include sampling networks for radioactive and chemical contaminants in stormwater to meet permit application requirements under the Clean Water Act. Monitoring results are compared with applicable Environmental Protection Agency (EPA) standards, DOE derived concentration guides (DCGs), dose limits, and other requirements in DOE.orders. Environmental standards are established to protect public health and the environment. Results of environmental monitoring during 1991 indicate that average concentrations of radioactive contaminants of concern were well below applicable standards and DCGS. Concentrations of some chemical contaminants in groundwater were above-the New York State Department of Environmental Conservation (Class GA) and EPA guidelines for drinking water. The potential annual radiation exposure (excluding background) calculated for a hypothetical maximally exposed individual is 0.23 mrem (milliroentgen equivalent man), which is less than an individual would receive while traveling in an airplane at 12,000 meters (39,000 feet) for one hour.« less

Luminescent properties of Cr-doped (GdX, Y1-X)3Al5O12 infra-red scintillator crystals

NASA Astrophysics Data System (ADS)

Suzuki, Akira; Kurosawa, Shunsuke; Yamaji, Akihiro; Shoji, Yasuhiro; Pejchal, Jan; Kamada, Kei; Yokota, Yuui; Yoshikawa, Akira

2014-10-01

Cr-doped (GdX Y1-X)3Al5O12 (X = 0, 0.25, 0.50) crystals prepared by the micro-pulling down method were investigated to develop a infra-red scintillator for implantable patient dosimeter in radiation therapy. In order to evaluate their optical and scintillation performance, the following properties were measured: (i) transmittance between ultra-violet and near-infra red region, (ii) photoluminescence spectra under Xe-lamp excitation, and (iii) X-ray excited radio-luminescence spectra. Cr:Y3Al5O12 and Cr:(Gd0.25 Y0.75)3Al5O12 crystals showed increased transmittance of 80%, while Cr:(Gd0.50 Y0.50)3Al5O12 had a lower transmittance of 40% due to its polycrystalline structure. In addition, all the Cr:(GdX Y1-X)3Al5O12 crystals showed sharp scintillation luminescence peaks ascribed to Cr3+ d-d transitions. Therefore, these results suggested that Cr:Y3Al5O12 and Cr:(Gd0.25 Y0.75)3Al5O12 crystals can be candidate materials for the dosimeter use.

Human Repsonse to Sonic Booms: A Research Program Plan

DTIC Science & Technology

1970-02-01

low- 10 1 - - - BEjgia i läysi y, tZ:,Ä\\m, voltage, fast EEG stages of sleep that occur In the last half of the night, stimulus intensities no...effect of noise v«ith a mean of 83 dB on rats and found a significant increase in heart weight after three weeks of intermit - tent exposure...catecholamines. Environmental stress is clearly related to an increase in lipid levels. Friedman et al. (1967), using 102-dB noise with intermit

Evaluation of Koontz Lake (North Indiana) Ecological Restoration Options - Comparison of Dredging and Aeration - and Broad Application to USACE Projects

DTIC Science & Technology

2018-01-01

Restoration Options – Comparison of Dredging and Aeration – and Broad Application to USACE Projects En vi ro nm en ta l L ab or at or y Victor F. Medina... Projects Victor F. Medina, Kaytee Pokrzywinski, and Edith Martinez-Guerra Environmental Laboratory U.S. Army Engineer Research and Development...Operations Technical Support Program 3909 Halls Ferry Road Vicksburg, MS 39180 Under Project No. TA2017-002, “Evaluation of Koontz Lake (Indiana

Contamination Assessment Report, Site 26-6: Basin F. Version 3.3. Phase 1

DTIC Science & Technology

1988-05-01

88173R02 AD-A2 7 5 700 -’ lEtUIUI LITIGATION TECHNICAL SUPPORT AND SERVICES Rocky Mountain Arsenal DTIC r ELECTF- FINAL PHASE I Q FEB7 1994...PREPARED BY ENVIRONMENTAL SCIENCE AND ENGINEERING, INC. Harding Lawson Associates Midwest Research Institute (Prepared under Task 19) Rocky- Mountain ...Arspn• FILE COP y Information Center PREPARED FOR Commerce City, Colorad U.S. ARMY PROGRAM MANAGER’S OFFICE FOR ROCKY MOUNTAIN ARSENAL THE INFORMATION

Installation Restoration Program Phase 2 - Confirmation/Quantification Stage 1 for Air Force Plant PJKS, Waterton, Colorado. Volume 1

DTIC Science & Technology

1986-10-06

surface geophyjcal sur’.-y using electrical recistivity and magnetometer to delineate the buried -renche , to prove the e zist nc./ae~ neme. of b~r...Department of Energy’s garbage-to-gas proof of concept facility at Pompano Beach, Florida. As Co-investigator conducting Bacterial and Trace Organic...advised the bacteri - ological analyst on techniques for identification and quantitation of environmentally important bacteria. 1984-1985 Chem-Technics, Inc

The DoD Environmental Restoration Program: An Air Force Perspective and Status Update

DTIC Science & Technology

2011-11-01

PFCs of interest Perfluorooctane sulfonate ( PFOS ) Perfluorooctanoic acid ( PFOA ) C8HF17O3S C8HF15O2 I n t e g r i t y - S...Mixtures Change in science/methods Evaluation in progress Perchlorate Lower regulatory standards Continue to monitor PFCs ( PFOS / PFOA ) Regulatory interest...e 25 DoD Activities: PFCs PFOA / PFOS on the DoD Emerging Contaminant Watch List for continued surveillance of regulatory actions SERDP

Targeting Phosphatidylserine for Radioimmunotherapy of Breast Cancer Brain Metastasis

DTIC Science & Technology

2013-10-01

Pharmaceuticals , Inc., Department of Defense grants PC05031 (to P.E. Thorpe) and PC080475 (to Y. Yin), an NIH-supported Small Animal Imaging Research Program...PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012...Army Medical Research And Materiel Command 11. SPONSOR/MONITOR’S REPORT Fort Detrick, Maryland NUMBER(S) 21702-5012 12. DISTRIBUTION / AVAILABILITY

A Novel Lecture Series and Associated Outreach Program in the Environmental and Natural Sciences

ERIC Educational Resources Information Center

Banner, Jay L.; Guda, Nelson; James, Eric W.; Stern, Libby A.; Zavala, Brian; Gordon, Jessica D.

2008-01-01

To address the low priority given to university-level outreach, the authors created an outreach program that makes it easy for scientists to connect with the public, while at the same time providing effective transfer of scientific research results to the public and the K-12 community. The result is a program called the Hot Science--Cool Talks…

Project Learning Tree. A Program of the American Forest Foundation.

ERIC Educational Resources Information Center

American Forest Foundation, Washington, DC.

Project Learning Tree (PLT) is a supplementary environmental education program intended for use in and out of the classroom with young people, their leaders, and teachers in kindergarten through grade 12. The PLT curriculum provides supplementary activities in various subject areas, such as social studies, language arts, mathematics, science, and…

ASBESTOS CONTAINING MATERIALS IN SCHOOL BUILDINGS: BULK SAMPLE ANALYSIS QUALITY ASSURANCE PROGRAM. BULK SAMPLE ROUNDS 12, 13 AND BLIND ROUND III

EPA Science Inventory

The report presents the results of laboratories participating in the twelveth, thirteenth and third (III) blind round of the bulk sample analysis quality assurance program sponsored by the U.S. Environmental Protection Agency. Three hundred twenty-three, 386 and 51 laboratories w...

75 FR 3723 - Agency Information Collection Activities; Proposed Collections; Comment Requests; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

...; Information Requirements for Importation of Nonconforming Vehicles; EPA ICR No. 0010.12, OMB Control No. 2060... Certification Program, EPA ICR No. 116.09, OMB Control No. 2060-0060; and Motor Vehicle and Engine Compliance Program Fees, EPA ICR 2080.04, OMB Control No. 2060-0545 AGENCY: Environmental Protection Agency (EPA...

Environmental Compliance Assessment and Management Program (ECAMP), South Carolina Supplement

DTIC Science & Technology

1994-04-01

Carbaryl 63252 25.00 Carbon Disulfide 75150 150.00 Carbon Tetrachloride 56235 150.00. Carbonyl Sulfide 463581 12250.00 Catechol 120809 297.00...7.50 Propoxur H4261 2.50 Propylene Dichloride 78875 1750.00 1.2 Propylene Oxide 75569 250.00 Propylenimine (1.2-) 75558 23.35 Pyrethrin 1 121211 25(X

Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-05-01

This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specifiedmore » in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.« less

Nuclear Blast Response Computer Program. Volume I. Program Description.

DTIC Science & Technology

1981-08-01

VEL 13 - AAS / , \\ / I ’ / I 4 2 Y VERTICAL PLANE NRMAL ’ , TO XAAs 3 / / , / 12 -’C’- Figure 6. Blast Orientations for Aero Module The spacing of...lag across 75 ’ " -0- Zi I ,AAS \\ \\ &,8 (8) VEgrrCA PLANE S .NORMAL TO YAAS XAAS VEL / ) - . +/ f \\ " 4 (4) 2 (2) 3 (3) Corresponding Aero...DEFINITION CDIl I Li NTFM-MXOPD ANUM TEMPORARY ARRAYS FOP 2 L2 NTFM-MXOFD ADEN FORMING TRANSFEF 3 L3 2-MXCRE ATEN FUNCTION POLYNOMIALS 4 L4 2.MXCRE

Longitudinal spin Seebeck effect in various garnet ferrites

NASA Astrophysics Data System (ADS)

Uchida, K.; Nonaka, T.; Kikkawa, T.; Kajiwara, Y.; Saitoh, E.

2013-03-01

The longitudinal spin Seebeck effect (LSSE) is investigated in various garnet ferrites Y3-xRxFe5-yMyO12 (R=Gd, Ca; M=Al, Mn, V, In, Zr) by means of the inverse spin Hall effect in Pt films. The magnitude of the LSSE voltage in the Pt/Y3-xRxFe5-yMyO12 samples is found to be enhanced with increasing concentration of Fe in the garnet ferrites, which can be explained by a change in the spin-mixing conductance at the Pt/Y3-xRxFe5-yMyO12 interfaces. We also investigate the dependence of the LSSE voltage on macroscopic magnetic parameters of Y3-xRxFe5-yMyO12. The experimental results show that the LSSE voltage in the Pt/Y3-xRxFe5-yMyO12 samples has a positive correlation with the Curie temperature and the saturation magnetization, but no clear correlation with the gyromagnetic ratio and the Gilbert damping constant of the samples.

Remedial Investigation Report Area of Contamination (AOC) 43J. Volume 2 of 2: Appendices A through N

DTIC Science & Technology

1996-02-01

olive gray (2.5Y 5/6) (SP) (Till) 8 0.5 9 S-3 9-11 ------ 487.2 SAND - Similar to S-2, wet, fuel odor 28-19-17-17 1.5 (SM-SP) 10 2.0 11 S- 4 11-13...1-2PPM 1.5 2- 4 -5-13 8 2.0 - 9 S-5 9-11 ------ 350- SANDY SILT (till) poorly graded, 5-12% fines, 10 gravel, very 13-19-15-22 1.8 500PPM fine...10% gravel, moist - wet, 16 50 for 0 drill in rock 15 S- 8 15-17 0.5 olive brown 2.5Y 4 /2 (till) (SM-SP) ABB Environmental Services, Inc. S O 1 L B OR

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

PubMed

Smith, Thomas H; Li, Julia G; Dores, Michael R; Trejo, JoAnn

2017-08-18

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the purinergic receptor P2Y12 to coordinate β-arrestin-mediated Akt signaling, an important mediator of integrin activation. However, the mechanism by which the PAR4-P2Y12 dimer controls β-arrestin-dependent Akt signaling is not known. We now report that PAR4 and P2Y12 heterodimer internalization is required for β-arrestin recruitment to endosomes and Akt signaling. Using bioluminescence resonance energy transfer, immunofluorescence microscopy, and co-immunoprecipitation in cells expressing receptors exogenously and endogenously, we demonstrate that PAR4 and P2Y12 specifically interact and form dimers expressed at the cell surface. We also found that activation of PAR4 but not of P2Y12 drives internalization of the PAR4-P2Y12 heterodimer. Remarkably, activated PAR4 internalization was required for recruitment of β-arrestin to endocytic vesicles, which was dependent on co-expression of P2Y12. Interestingly, stimulation of the PAR4-P2Y12 heterodimer promotes β-arrestin and Akt co-localization to intracellular vesicles. Moreover, activated PAR4-P2Y12 internalization is required for sustained Akt activation. Thus, internalization of the PAR4-P2Y12 heterodimer is necessary for β-arrestin recruitment to endosomes and Akt signaling and lays the foundation for examining whether blockade of PAR4 internalization reduces integrin and platelet activation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Hanford`s innovations for science education

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, D.

1996-12-31

In recognition of declining science literacy in the United States and a projected shortfall of scientists, engineers and technologists to address environmental problems nationally and internationally during the 21st century, Westinghouse Hanford Company has launched several innovative science education projects at the US Department of Energy Hanford Site. The Hanford Site is very rich in resources that can be brought to bear on the problem: world-class technical experts, state of the art facilities and equipment, and the largest environmental laboratory in the world. During the past two years, several innovative science education initiatives have been conceived and pursued at themore » secondary education level including the International Academy for the Environment (residential high school with an environmental theme), Environmental BATTmobile Program (mobile middle school science education program), and Multicultural Experiences in Math and Science (education program based on cultural contributions to math and science). Hanford scientists, engineers and administrators have worked with the education community (K-12 and college-university) to develop innovative approaches to science education.« less

Genetic and environmental factors affecting self-esteem from age 14 to 17: a longitudinal study of Finnish twins

PubMed Central

Raevuori, Anu; Dick, Danielle M.; Keski-Rahkonen, Anna; Pulkkinen, Lea; Rose, Richard J.; Rissanen, Aila; Kaprio, Jaakko; Viken, Richard J.; Silventoinen, Karri

2007-01-01

Background We analysed genetic and environmental influences on self-esteem and its stability across adolescence. Methods Finnish twins born in 1983–1987 were assessed by questionnaire at ages 14y (N= 4132 twin individuals) and 17y (N=3841 twin individuals). Self esteem was measured using the Rosenberg global self-esteem scale and analyzed using quantitative genetic methods for twin data in the Mx statistical package. Results The heritability of self-esteem was 0.62 (95% CI 0.56–0.68) in 14-y-old boys and 0.40 (95% CI 0.26–0.54) in 14-y-old girls, while the corresponding estimates at age 17y were 0.48 (95% CI 0.39–0.56) and 0.29 (95% CI 0.11–0.45). Rosenberg self-esteem scores at age 14 y and 17 y were modestly correlated (r=0.44 in boys, r=0.46 in girls). In boys, the correlation was mainly (82%) due to genetic factors, with residual co-variation due to unique environment. In girls, genetic (31%) and common environmental (61%) factors largely explained the correlation. Conclusions In adolescence, self-esteem seems to be differently regulated in boys versus girls. A key challenge for future research is to identify environmental influences contributing to self-esteem during adolescence and how these factors interact with genetic influences. PMID:17537282

Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: the VERIfy Thrombosis risk ASsessment (VERITAS) study.

PubMed

Malinin, Alex; Pokov, Alex; Spergling, Malcolm; Defranco, Anthony; Schwartz, Kenneth; Schwartz, Dianne; Mahmud, Ehtisham; Atar, Dan; Serebruany, Victor

2007-01-01

Clopidogrel inhibits platelet P2Y12 ADP receptors, while ADP, as an inductor of aggregation, stimulates both P2Y12 and P2Y1 platelet receptors. Despite a clinical loading dose routine with clopidogrel, some patients still experience coronary stent thrombosis suggesting persistent platelet activation. The VerifyNow-P2Y12 is a rapid assay that test platelet activity over 3 min and uses of the combination of ADP and prostaglandin E1 (PGE1) to directly measure the effects of clopidogrel on the P2Y12 receptor. ADP is used to maximally activate the platelets by binding to the P2Y1 and P2Y12 platelet receptors, while PGE1 is used to suppress the ADP-induced P2Y1-mediated increase in intracellular calcium levels. The VERIfy Thrombosis risk ASsessment (VERITAS) was a prospective study designed to measure platelet response to clopidogrel therapy in subjects with multiple risk factors or history of vascular disease using this novel point-of-care assay. 166 participants were enrolled in 4 participating sites. Data from 147 participants were analyzed after exclusion of 19 patients due to protocol violations. Platelets were assessed twice at baseline (before clopidogrel) and at 24 h post-loading 450 mg (110 participants) or 7 days after chronic clopidogrel treatment (75 mg/day) (37 patients). All participants received aspirin 81-325 mg for at least 2 days before the study enrollment. Results from the VerifyNow-P2Y12 assay are reported in P2Y12 reaction units (PRU). Clopidogrel therapy resulted in a mean 64.0+/-25.3% PRU reduction. No participant reached PRU inhibition below 10% of baseline. Distribution of PRU values for the VerifyNow-P2Y12 assay shows a separation from baseline to post-clopidogrel assay values with some overlap due to high inter-individual variations in response. VerifyNow-P2Y12 is a reliable, fast and sensitive device suitable for monitoring of platelet inhibition during clopidogrel therapy.

Hospitalizations for pneumonia, invasive diseases and otitis in Tuscany (Italy), 2002-2014: Which was the impact of universal pneumococcal pediatric vaccination?

PubMed

Boccalini, Sara; Varone, Ornella; Chellini, Martina; Pieri, Luca; Sala, Antonino; Berardi, Cesare; Bonanni, Paolo; Bechini, Angela

2017-02-01

Streptococcus pneumoniae is the main causative organism of acute media otitis in children and meningitis and bacterial pneumonia in the community. Since 2008 in Tuscany, central Italy, the pneumococcal conjugate vaccine (7-valent vaccine, switched to 13-valent vaccine in 2010) was actively offered free of charge to all newborns. Aim of the study is to evaluate the impact of pneumococcal pediatric vaccination in the Tuscan population on hospitalizations potentially caused by S. pneumoniae, during pre-vaccination (PVP, 2002-2007) and vaccination period (VP, 2009-2014). We analyzed hospital discharge records (HDRs) of all hospitals in Tuscany from 2002 to 2014. Hospitalizations potentially due to pneumococcal diseases were 347, 221. The general hospitalization rate was 716/100,000 inhabitants during PVP and 753/100,000 in VP, with a decrease of 29.1% in the age-group 0-9 y ("target" of the vaccination program) and an increase of 75.7% in subjects >64 y of age. During VP, admission days and hospitalization costs increased (6.2% and 24.2%, respectively), especially in patients >64 y (12.9% and 33.8%, respectively); in children <10 y decreased by 21.2% and 12.8%, respectively. The pneumococcal pediatric vaccination resulted in the decrease of hospitalizations in younger but the expected indirect effect in the elderly was not reported, justifying the Tuscan recommendation to extend the vaccination to subjects > 64 y.

Exploring the environmental effects of shale gas development in the Chesapeake Bay watershed

Treesearch

Scientific and Technical Committee [STAC] Chesapeake Bay Program

2013-01-01

On April 11-12, 2012, the Chesapeake Bay Program's Scientific and Technical Advisory Committee (STAC) convened an expert workshop to investigate the environmental effects of shale gas development in the Chesapeake Bay Watershed. The purpose of this workshop was to engage scientists from across the nation in a review of the state-of-the-science regarding shale gas...

Post-Coma Persons with Motor and Communication/Consciousness Impairments Choose among Environmental Stimuli and Request Stimulus Repetitions via Assistive Technology

ERIC Educational Resources Information Center

Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Buonocunto, Francesca; Sacco, Valentina; Colonna, Fabio; Navarro, Jorge; Lanzilotti, Crocifissa; Oliva, Doretta; Megna, Gianfranco

2010-01-01

This study assessed whether a program based on microswitch and computer technology would enable three post-coma participants (adults) with motor and communication/consciousness impairments to choose among environmental stimuli and request their repetition whenever they so desired. Within each session, 16 stimuli (12 preferred and 4 non-preferred)…

Interacting with the Environment--Eddyville School.

ERIC Educational Resources Information Center

Mitchell, Jeff; Owen, Sarah

1988-01-01

Describes some of the aspects of the environmental education program at a K-12 school located in the Coast Range of Oregon. Discusses activities relating to wildlife biology, forestry, beekeeping, pesticides, and land use. (TW)

Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding.

PubMed

Mundell, S J; Rabbolini, D; Gabrielli, S; Chen, Q; Aungraheeta, R; Hutchinson, J L; Kilo, T; Mackay, J; Ward, C M; Stevenson, W; Morel-Kopp, M-C

2018-01-01

Essentials Three dominant variants for the autosomal recessive bleeding disorder type-8 have been described. To date, there has been no phenotype/genotype correlation explaining their dominant transmission. Proline plays an important role in P2Y12R ligand binding and signaling defects. P2Y12R homodimer formation is critical for the receptor function and signaling. Background Although inherited platelet disorders are still underdiagnosed worldwide, advances in molecular techniques are improving disease diagnosis and patient management. Objective To identify and characterize the mechanism underlying the bleeding phenotype in a Caucasian family with an autosomal dominant P2RY12 variant. Methods Full blood counts, platelet aggregometry, flow cytometry and western blotting were performed before next-generation sequencing (NGS). Detailed molecular analysis of the identified variant of the P2Y12 receptor (P2Y12R) was subsequently performed in mammalian cells overexpressing receptor constructs. Results All three referred individuals had markedly impaired ADP-induced platelet aggregation with primary wave only, despite normal total and surface P2Y12R expression. By NGS, a single P2RY12:c.G794C substitution (p.R265P) was identified in all affected individuals, and this was confirmed by Sanger sequencing. Mammalian cell experiments with the R265P-P2Y12R variant showed normal receptor surface expression versus wild-type (WT) P2Y12R. Agonist-stimulated R265P-P2Y12R function (both signaling and surface receptor loss) was reduced versus WT P2Y12R. Critically, R265P-P2Y12R acted in a dominant negative manner, with agonist-stimulated WT P2Y12R activity being reduced by variant coexpression, suggesting dramatic loss of WT homodimers. Importantly, platelet P2RY12 cDNA cloning and sequencing in two affected individuals also revealed three-fold mutant mRNA overexpression, decreasing even further the likelihood of WT homodimer formation. R265 located within extracellular loop 3 (EL3) is one of four residues that are important for receptor functional integrity, maintaining the binding pocket conformation and allowing rotation following ligand binding. Conclusion This novel dominant negative variant confirms the important role of R265 in EL3 in the functional integrity of P2Y12R, and suggests that pathologic heterodimer formation may underlie this family bleeding phenotype. © 2017 International Society on Thrombosis and Haemostasis.

World bank and the environment. Progress report. Banco mundial y el medio ambiente

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-01-01

The second annual report describes specific environmental strategies and environmental lending in the Bank's four operational regions: Africa; Asia; Europe, Middle East, and North Africa; and Latin America and the Caribbean. It details the Bank's progress in eight environmental categories: energy and the environment, pollution, urban environment, water resources management, forest and land management, social and cultural, environmental economics, and the global environment. One chapter is devoted exclusively to tropical forests, studying ways in which the Bank is dealing with deforestation as a part of the constant review of its forest policies. Suggestions are made for decreasing the degradation ofmore » tropical forests while meeting demands for forest products. This chapter reflects a shift in Bank emphasis from commercial ventures to conservation measures. The publication reports on other initiatives by the Bank during fiscal 1991, including the launching of the Global Environment Facility (GEF)--a pilot program to oversee reduction of global warming, preservation of biological diversity, protection of international waters, and prevention of ozone depletion.« less

Integrating long-term science projects into K-12 curriculum: Fostering teacher-student engagement in urban environmental research through an NSF UCLA GK-12 program

NASA Astrophysics Data System (ADS)

Hogue, T. S.; Moldwin, M.; Nonacs, P.; Daniel, J.; Shope, R.

2009-12-01

A National Science Foundation Graduate Teaching Fellows in K- 12 Education program at UCLA (SEE-LA; http://measure.igpp.ucla.edu/GK12-SEE-LA) has just completed its first year (of a five-year program) and has greatly expanded UCLA’s science and engineering partnerships with LA Unified and Culver City Unified School Districts. The SEE-LA program partners UCLA faculty, graduate students (fellows), middle and high school science teachers and their students into a program of science and engineering exploration that brings the environment of Los Angeles into the classroom. UCLA graduate fellows serve as scientists-in-residence at the four partner schools to integrate inquiry-based science and engineering lessons, facilitate advancements in science content teaching, and ultimately, to improve their own science communication skills. As part of their fellowship, graduate students are required to develop three inquiry-based lessons in their partner classroom, including a lesson focused on their dissertation research, a lesson focused on the environmental/watershed theme of the project, and a lesson that involves longer-term data collection and synthesis with the grade 6-12 teachers and students. The developed long-term projects ideally involve continued observations and analysis through the five-year project and beyond. During the first year of the project, the ten SEE-LA fellows developed a range of long-term research projects, from seasonal invertebrate observations in an urban stream system, to home energy consumption surveys, to a school bioblitz (quantification of campus animals and insects). Examples of lesson development and integration in the classroom setting will be highlighted as well as tools required for sustainability of the projects. University and local pre-college school partnerships provide an excellent opportunity to support the development of graduate student communication skills while also contributing significantly to the integration of sustainable research projects into K-12 curriculum.

School-based obesity prevention interventions for Chilean children during the past decades: lessons learned.

PubMed

Kain, Juliana; Uauy, Ricardo; Concha, Fernando; Leyton, Bárbara; Bustos, Nelly; Salazar, Gabriela; Lobos, Luz; Vio, Fernando

2012-07-01

Obesity in Chilean children has increased markedly over the past decades. School-based obesity prevention interventions have been launched by the Ministry of Health and academic groups to tackle this condition. We summarize the main characteristics of the interventions that we have conducted and reflect on the lessons learned. Since 2002, we conducted 1 pilot study, a 2-y controlled intervention including 6- to 12-y-old children (Casablanca), another pilot study, and a 2-y controlled intervention including teachers and their 4- to 9-y-old students (Macul). Both interventions consisted of training teachers to deliver contents on healthy eating, increasing physical education classes, and, additionally in Macul, teachers participated in a wellness program. BMI Z-score and obesity prevalence were compared among children in intervention and control schools by year and among students of intervention and control teachers. In the Casablanca study, the impact was greatest on the younger children during the first school year when the study received the full funding that was required. In Macul, although intervention teachers exhibited improvements in anthropometry and blood measures, the impact on the children was not related to their results. The main lessons learned from these experiences are random allocation of schools, although methodologically desirable, is not always possible; participation of parents is very limited; obesity is not recognized as a problem; and increasing physical activity and implementing training programs for teachers is difficult due to an inflexible curriculum and lack of teachers' time. Unless these barriers are overcome, obesity prevention programs will not produce positive and lasting outcomes.

Y2K: the moment of truth.

PubMed

Chepesiuk, R

1999-05-01

It remains to be seen whether the world will move in time to fix the Y2K bug, or whether computers around the world will shut down when the clock strikes midnight on 31 December 1999. Y2K could have a serious impact on environmental facilities, particularly given the extent to which computer software and microchips are now involved in pollution control and environmental monitoring and protection systems.

Y2K: the moment of truth.

PubMed Central

Chepesiuk, R

1999-01-01

It remains to be seen whether the world will move in time to fix the Y2K bug, or whether computers around the world will shut down when the clock strikes midnight on 31 December 1999. Y2K could have a serious impact on environmental facilities, particularly given the extent to which computer software and microchips are now involved in pollution control and environmental monitoring and protection systems. PMID:10210702

Summary Report: Forest Health Monitoring in the South, 1991

Treesearch

William A. Bechtold; William H. Hoffard; Robert L. Anderson

1992-01-01

The USDA Forest Service and the U.S. Environmental Protection Agency have launched a joint program to monitor the health of forests iu the United States. The program is still in the initial phases of implementation, but several indicators of forest health are undergoiug development and permanent plots have been established in 12 States. This report contains...

U.S.-MEXICO BORDER PROGRAM ARIZONA BORDER STUDY--STANDARD OPERATING PROCEDURE FOR CALIBRATION AND OPERATION OF NHEXAS BALANCES (UA-L-1.2)

EPA Science Inventory

The purpose of this SOP is to describe the procedures used when calibrating and operating balances during the Arizona NHEXAS project and the Border study. Keywords: lab; equipment; balances.

The U.S.-Mexico Border Program is sponsored by the Environmental Health Workgroup of t...

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (82nd, New Orleans, Louisiana, August 3-8, 1999). Advertising, Part 1.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Advertising, Part 1 section of the Proceedings contains the following 12 papers: "Incorporating a Promotional Products Teaching Component into the Advertising Campaigns Course: A Partnership Pilot Program" (Denise E. DeLorme); "Information Cues in Renmin Ribao Advertisements (1979-1998)" (Susanna W. Y. Kwok); "Impact…

A national outbreak of Salmonella serotype Tennessee infections from contaminated peanut butter: a new food vehicle for salmonellosis in the United States.

PubMed

Sheth, Anandi N; Hoekstra, Mike; Patel, Nehal; Ewald, Gwen; Lord, Cathy; Clarke, Carmen; Villamil, Elizabeth; Niksich, Katherine; Bopp, Cheryl; Nguyen, Thai-An; Zink, Donald; Lynch, Michael

2011-08-01

Salmonella serotype Tennessee is a rare cause of the estimated 1 million cases of salmonellosis occurring annually in the United States. In January 2007, we began investigating a nationwide increase in Salmonella Tennessee infections. We defined a case as Salmonella Tennessee infection in a patient whose isolate demonstrated 1 of 3 closely related pulsed-field gel electrophoresis patterns and whose illness began during the period 1 August 2006 through 31 July 2007. We conducted a case-control study in 22 states and performed laboratory testing of foods and environmental samples. We identified 715 cases in 48 states; 37% of isolates were from urine specimens. Illness was associated with consuming peanut butter more than once a week (matched odds ratio [mOR], 3.5 [95% confidence interval {95% CI}, 1.4-9.9]), consuming Brand X peanut butter (mOR, 12.1 [95% CI, 3.6-66.3]), and consuming Brand Y peanut butter (mOR, 9.1 [95% CI, 1.0-433]). Brands X and Y were produced in 1 plant, which ceased production and recalled products on 14 February 2007. Laboratories isolated outbreak strains of Salmonella Tennessee from 34 Brands X and Y peanut butter jars and 2 plant environmental samples. This large, widespread outbreak of salmonellosis is the first linked to peanut butter in the United States; a nationwide recall resulted in outbreak control. Environmental contamination in the peanut butter plant likely caused this outbreak. This outbreak highlights the risk of salmonellosis from heat-processed foods of nonanimal origin previously felt to be low risk for Salmonella contamination.

The effect of trade books on the environmental literacy of 11th and 12th graders in aquatic science

NASA Astrophysics Data System (ADS)

Lewis, Ann S.

The purpose of this study was to compare the environmental literacy of 11th and 12th graders who participated in an eighteen-week environmental education program using trade books versus 11 th- and 12th-graders who participated in an eighteen-week, traditional environmental education program without the use of trade books. This study was conducted using a quasi-experimental research technique. Four high school aquatic science classes at two suburban high schools were used in the research. One teacher at each high school taught one control class and one experimental class of aquatic science. In the experimental classes, four trade books were read to the classes during the eighteen-week semester. These four books were selected by the participating teachers before the semester began. The books used were A Home by the Sea, Sea Otter Rescue, There's a Hair in My Dirt, and The Missing Gator of Gumbo Limbo. The instrument used to measure environmental literacy was the Children's Environmental Attitude and Knowledge Scale. This test was given at the beginning of the semester and at the end of the semester. The scores at the end of the semester were analyzed by 2 x 2 mixed model ANOVA with the teacher as the random effect and the condition (trade books) as the fixed effect. The statistical analysis of this study showed that the students in the experimental classes did not score higher than the control classes on the Children's Environmental Attitude and Knowledge Scale or on a subset of "water" questions. Several limitations were placed on this research. These limitations included the following: (1) a small number of classes and a small number of teachers, (2) change from the original plan of using environmental science classes to aquatic science classes, (3) possible indifference of the students, and (4) restrictive teaching strategies of the teachers.

Effect of an Environmental School-based Obesity Prevention Program On Changes in Body Fat and Body Weight: A Randomized Trial

PubMed Central

Williamson, D.A.; Champagne, C.M.; Harsha, D.; Han, H.; Martin, C.K.; Newton, R.L.; Sothern, M.; Stewart, T.M.; Webber, L.S.; Ryan, D.

2012-01-01

This study tested the efficacy of two school-based programs for prevention of body weight/fat gain in comparison to a control group, in all participants and in overweight children. The Louisiana (LA) Health study utilized a longitudinal, cluster randomized 3-arm controlled design, with 28 months of follow-up. Children (N=2060; M age = 10.5 years, SD = 1.2) from rural communities in Grades 4 to 6 participated in the study. 17 school clusters (M = 123 children/cluster) were randomly assigned to one of three prevention arms: 1) Primary Prevention (PP), an environmental modification program, 2) Primary + Secondary Prevention (PP+SP), the environmental program with an added classroom and internet education component, or 3) Control (C). Primary outcomes were changes in percent body fat and body mass index z scores. Secondary outcomes were changes in behaviors related to energy balance. Comparisons of PP, PP+SP, and C on changes in body fat and BMI z scores found no differences. PP and PP+SP study arms were combined to create an environmental modification arm (EM). Relative to C, EM decreased body fat for boys (−1.7% ± 0.38% versus −0.14% ± 0.69%) and attenuated fat gain for girls (2.9% ± 0.22% versus 3.93% ± 0.37%), but standardized effect sizes were relatively small (< 0.30). In conclusion, this school-based environmental modification programs had modest beneficial effects on changes in percent body fat. Addition of a classroom/internet program to the environmental program did not enhance weight/fat gain prevention, but did impact physical activity and social support in overweight children. PMID:22402733

Iowa's Clean Solid Waste Environmental Education Project (SWEEP).

ERIC Educational Resources Information Center

Eells, Jean Crim; And Others

The Iowa Clean SWEEP program is designed to provide educators, K-12, with a series of activities focusing upon critical concepts related to Iowa's solid waste problem. This activity packet contains 19 activities for grades K-6, and 25 activities for grades 7-12. Key concepts addressed throughout the activity packet include: (1) an overview, the…

The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.

PubMed

Ohlmann, Philippe; Lecchi, Anna; El-Tayeb, Ali; Müller, Christa E; Cattaneo, Marco; Gachet, Christian

2013-03-01

Various radioligands have been used to characterize and quantify the platelet P2Y(12) receptor, which share several weaknesses: (a) they are metabolically unstable and substrates for ectoenzymes, (b) they are agonists, and (c) they do not discriminate between P2Y(1) and P2Y(12). We used the [(3)H]PSB-0413 selective P2Y(12) receptor antagonist radioligand to reevaluate the number of P2Y(12) receptors in intact platelets and in membrane preparations. Studies in humans showed that: (1) [(3)H]PSB-0413 bound to 425 ± 50 sites/platelet (K (D) = 3.3 ± 0.6 nM), (2) 0.5 ± 0.2 pmol [(3)H]PSB-0413 bound to 1 mg protein of platelet membranes (K (D) = 6.5 ± 3.6 nM), and (3) competition studies confirmed the known features of P2Y(12), with the expected rank order of potency: AR-C69931MX > 2MeSADP ≫ ADPβS > ADP, while the P2Y(1) ligand MRS2179 and the P2X(1) ligand α,β-Met-ATP did not displace [(3)H]PSB-0413 binding. Patients with severe P2Y(12) deficiency displayed virtually no binding of [(3)H]PSB-0413 to intact platelets, while a patient with a dysfunctional P2Y(12) receptor had normal binding. Studies in mice showed that: (1) [(3)H]PSB-0413 bound to 634 ± 87 sites/platelet (K (D) = 14 ± 4.5 nM) and (2) 0.7 pmol ± 0.3 [(3)H]PSB-0413 bound to 1 mg protein of platelet membranes (K (D) = 9.1 ± 5.3 nM). Clopidogrel and other thiol reagents like pCMBS or DTT abolished the binding both to intact platelets and membrane preparations. Therefore, [(3)H]PSB-0413 is an accurate and selective tool for radioligand binding studies aimed at quantifying P2Y(12) receptors, to identify patients with P2Y(12) deficiencies or quantify the effect of P2Y(12) targeting drugs.

Integrating science with humanities-loosing the fear of science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pinto, W.L.; Raphalides, S.; Edwards, D.

1994-12-31

This presentation illustrates the approach and effectiveness of an interactive seminar program for K-12 non-science teachers (funded by the NJ Dept. of Higher Education) aimed at integrating the humanities and science, especially environmental sciences. Teachers become comfortable dealing with the commonality of science, literature, and human culture. In a collaborative format between seminar organizers and K-12 teachers, participants contribute their understanding of literature, history, politics, and culture to develop a new outlook on {open_quotes}environmental awareness{close_quotes} and on pollution`s impact on society. Prehistoric, medieval, 18th century, modern western cultures, Oriental, Native American, and tropical island cultures are explored to shed lightmore » upon today`s environmental attitudes. This provides a better understanding of the way science, within a cultural context, approaches environmental problems.« less

Complete Genome Sequence of Paenibacillus strain Y4.12MC10, a Novel Paenibacillus lautus strain Isolated from Obsidian Hot Spring in Yellowstone National Park

PubMed Central

Mead, David A.; Lucas, Susan; Copeland, Alex; Lapidus, Alla; Cheng, Jan-Feng; Bruce, David C.; Goodwin, Lynne A.; Pitluck, Sam; Chertkov, Olga; Zhang, Xiaojing; Detter, John C.; Han, Cliff S.; Tapia, Roxanne; Land, Miriam; Hauser, Loren J.; Chang, Yun-juan; Kyrpides, Nikos C.; Ivanova, Natalia N.; Ovchinnikova, Galina; Woyke, Tanja; Brumm, Catherine; Hochstein, Rebecca; Schoenfeld, Thomas; Brumm, Phillip

2012-01-01

Paenibacillus sp.Y412MC10 was one of a number of organisms isolated from Obsidian Hot Spring, Yellowstone National Park, Montana, USA under permit from the National Park Service. The isolate was initially classified as a Geobacillus sp. Y412MC10 based on its isolation conditions and similarity to other organisms isolated from hot springs at Yellowstone National Park. Comparison of 16 S rRNA sequences within the Bacillales indicated that Geobacillus sp.Y412MC10 clustered with Paenibacillus species, and the organism was most closely related to Paenibacillus lautus. Lucigen Corp. prepared genomic DNA and the genome was sequenced, assembled, and annotated by the DOE Joint Genome Institute. The genome sequence was deposited at the NCBI in October 2009 (NC_013406). The genome of Paenibacillus sp. Y412MC10 consists of one circular chromosome of 7,121,665 bp with an average G+C content of 51.2%. Comparison to other Paenibacillus species shows the organism lacks nitrogen fixation, antibiotic production and social interaction genes reported in other paenibacilli. The Y412MC10 genome shows a high level of synteny and homology to the draft sequence of Paenibacillus sp. HGF5, an organism from the Human Microbiome Project (HMP) Reference Genomes. This, combined with genomic CAZyme analysis, suggests an intestinal, rather than environmental origin for Y412MC10. PMID:23408395

Complete Genome Sequence of Paenibacillus strain Y4.12MC10, a Novel Paenibacillus lautus strain Isolated from Obsidian Hot Spring in Yellowstone National Park.

PubMed

Mead, David A; Lucas, Susan; Copeland, Alex; Lapidus, Alla; Cheng, Jan-Feng; Bruce, David C; Goodwin, Lynne A; Pitluck, Sam; Chertkov, Olga; Zhang, Xiaojing; Detter, John C; Han, Cliff S; Tapia, Roxanne; Land, Miriam; Hauser, Loren J; Chang, Yun-Juan; Kyrpides, Nikos C; Ivanova, Natalia N; Ovchinnikova, Galina; Woyke, Tanja; Brumm, Catherine; Hochstein, Rebecca; Schoenfeld, Thomas; Brumm, Phillip

2012-07-30

Paenibacillus sp.Y412MC10 was one of a number of organisms isolated from Obsidian Hot Spring, Yellowstone National Park, Montana, USA under permit from the National Park Service. The isolate was initially classified as a Geobacillus sp. Y412MC10 based on its isolation conditions and similarity to other organisms isolated from hot springs at Yellowstone National Park. Comparison of 16 S rRNA sequences within the Bacillales indicated that Geobacillus sp.Y412MC10 clustered with Paenibacillus species, and the organism was most closely related to Paenibacillus lautus. Lucigen Corp. prepared genomic DNA and the genome was sequenced, assembled, and annotated by the DOE Joint Genome Institute. The genome sequence was deposited at the NCBI in October 2009 (NC_013406). The genome of Paenibacillus sp. Y412MC10 consists of one circular chromosome of 7,121,665 bp with an average G+C content of 51.2%. Comparison to other Paenibacillus species shows the organism lacks nitrogen fixation, antibiotic production and social interaction genes reported in other paenibacilli. The Y412MC10 genome shows a high level of synteny and homology to the draft sequence of Paenibacillus sp. HGF5, an organism from the Human Microbiome Project (HMP) Reference Genomes. This, combined with genomic CAZyme analysis, suggests an intestinal, rather than environmental origin for Y412MC10.

Strategies to Recruit a Diverse Low-Income Population to Child Weight Management Programs From Primary Care Practices.

PubMed

Barlow, Sarah E; Butte, Nancy F; Hoelscher, Deanna M; Salahuddin, Meliha; Pont, Stephen J

2017-12-21

Primary care practices can be used to engage children and families in weight management programs. The Texas Childhood Obesity Research Demonstration (TX CORD) study targeted patients at 12 primary care practices in diverse and low-income areas of Houston, Texas, and Austin, Texas for recruitment to a trial of weight management programs. This article describes recruitment strategies developed to benefit both families and health care practices and the modification of electronic health records (EHRs) to reflect recruitment outcomes. To facilitate family participation, materials and programs were provided in English and Spanish, and programs were conducted in convenient locations. To support health care practices, EHRs and print materials were provided to facilitate obesity recognition, screening, and study referral. We provided brief training for providers and their office staffs that covered screening patients for obesity, empathetic communication, obesity billing coding, and use of counseling materials. We collected EHR data from 2012 through 2014, including demographics, weight, and height, for all patients aged 2 to 12 years who were seen in the 12 provider practices during the study's recruitment phase. The data of patients with a body mass index (BMI) at or above the 85th percentile were compared with the same data for patients who were referred to the study and patients who enrolled in the study. We also examined reasons that patients referred to the study declined to participate. Overall, 26% of 7,845 patients with a BMI at or above the 85th percentile were referred to the study, and 27% of referred patients enrolled. Enrollment among patients with a BMI at or above the 85th percentile was associated with being Hispanic and with more severe obesity than with patients of other races/ethnicities or less severe obesity, respectively. Among families of children aged 2 to 5 years who were referred, 20% enrolled, compared with 30% of families of older children (>5 y to 12 y). Referral rates varied widely among the 12 primary care practices, and referral rates were not associated with EHR modifications. Engagement and recruitment strategies for enrolling families in primary care practice in weight management programs should be strengthened. Further study of factors associated with referral and enrollment, better systems for EHR tools, and data on provider and office adherence to study protocols should be examined. EHRs can track referral and enrollment to capture outcomes of recruitment efforts.

Strategies to Recruit a Diverse Low-Income Population to Child Weight Management Programs From Primary Care Practices

PubMed Central

Butte, Nancy F.; Hoelscher, Deanna M.; Salahuddin, Meliha; Pont, Stephen J.

2017-01-01

Purpose and Objectives Primary care practices can be used to engage children and families in weight management programs. The Texas Childhood Obesity Research Demonstration (TX CORD) study targeted patients at 12 primary care practices in diverse and low-income areas of Houston, Texas, and Austin, Texas for recruitment to a trial of weight management programs. This article describes recruitment strategies developed to benefit both families and health care practices and the modification of electronic health records (EHRs) to reflect recruitment outcomes. Intervention Approach To facilitate family participation, materials and programs were provided in English and Spanish, and programs were conducted in convenient locations. To support health care practices, EHRs and print materials were provided to facilitate obesity recognition, screening, and study referral. We provided brief training for providers and their office staffs that covered screening patients for obesity, empathetic communication, obesity billing coding, and use of counseling materials. Evaluation Methods We collected EHR data from 2012 through 2014, including demographics, weight, and height, for all patients aged 2 to 12 years who were seen in the 12 provider practices during the study’s recruitment phase. The data of patients with a body mass index (BMI) at or above the 85th percentile were compared with the same data for patients who were referred to the study and patients who enrolled in the study. We also examined reasons that patients referred to the study declined to participate. Results Overall, 26% of 7,845 patients with a BMI at or above the 85th percentile were referred to the study, and 27% of referred patients enrolled. Enrollment among patients with a BMI at or above the 85th percentile was associated with being Hispanic and with more severe obesity than with patients of other races/ethnicities or less severe obesity, respectively. Among families of children aged 2 to 5 years who were referred, 20% enrolled, compared with 30% of families of older children (>5 y to 12 y). Referral rates varied widely among the 12 primary care practices, and referral rates were not associated with EHR modifications. Implications for Public Health Engagement and recruitment strategies for enrolling families in primary care practice in weight management programs should be strengthened. Further study of factors associated with referral and enrollment, better systems for EHR tools, and data on provider and office adherence to study protocols should be examined. EHRs can track referral and enrollment to capture outcomes of recruitment efforts. PMID:29267156

Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response.

PubMed

Muniz, Valdirene S; Baptista-Dos-Reis, Renata; Benjamim, Claudia F; Mata-Santos, Hilton A; Pyrrho, Alexandre S; Strauch, Marcelo A; Melo, Paulo A; Vicentino, Amanda R R; Silva-Paiva, Juliana; Bandeira-Melo, Christianne; Weller, Peter F; Figueiredo, Rodrigo T; Neves, Josiane S

2015-01-01

Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have recently reported the expression of the purinergic P2Y12 receptor (P2Y12R) in human eosinophils; however, its functional role in this cell type and its involvement in eosinophilic inflammation remain unknown. Here, we investigated functional roles of P2Y12R in isolated human eosinophils and in a murine model of eosinophilic inflammation induced by Schistosoma mansoni (S. mansoni) infection. We found that adenosine 5'-diphosphate (ADP) induced human eosinophils to secrete eosinophil peroxidase (EPO) in a P2Y12R dependent manner. However, ADP did not interfere with human eosinophil apoptosis or chemotaxis in vitro. In vivo, C57Bl/6 mice were infected with cercariae of the Belo Horizonte strain of S. mansoni. Analyses performed 55 days post infection revealed that P2Y12R blockade reduced the granulomatous hepatic area and the eosinophilic infiltrate, collagen deposition and IL-13/IL-4 production in the liver without affecting the parasite oviposition. As found for humans, murine eosinophils also express the P2Y12R. P2Y12R inhibition increased blood eosinophilia, whereas it decreased the bone marrow eosinophil count. Our results suggest that P2Y12R has an important role in eosinophil EPO secretion and in establishing the inflammatory response in the course of a S. mansoni infection.

Environmental Cleanup of the East Tennessee Technology Park Year One - Execution with Certainty SM - 13120

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schubert, A.L.

2013-07-01

On August 1, 2011, URS - CH2M Oak Ridge LLC (UCOR) began its five-year, $1.4 billion cleanup of the East Tennessee Technology Park (ETTP), located on the U.S. Department of Energy's (DOE) Oak Ridge Reservation in Tennessee. UCOR will close out cleanup operations that began in 1998 under a previous contract. When the Contract Base scope of work [1] is completed in 2016, the K-25 gaseous diffusion building will have been demolished and all waste dispositioned, demolition will have started on the K-27 gaseous diffusion building, all contact-handled and remote-handled transuranic waste in inventory (approximately 500 cubic meters) will havemore » been transferred to the Transuranic Waste Processing Center, previously designated 'No-Path-To-Disposition Waste' will have been dispositioned to the extent possible, and UCOR will have managed DOE Office of Environmental Management (EM)- owned facilities at ETTP, Oak Ridge National Laboratory (ORNL), and the Y-12 National Security Complex in a safe and cost-effective manner. Since assuming its responsibilities as the ETTP cleanup contractor, UCOR has completed its life-cycle Performance Measurement Baseline; received its Earned Value Management System (EVMS) certification; advanced the deactivation and demolition (D and D) of the K-25 gaseous diffusion building; recovered and completed the Tank W-1A and K-1070-B Burial Ground remediation projects; characterized, packaged, and shipped contact-handled transuranic waste to the Transuranic Waste Processing Center; disposed of more than 90,000 cubic yards of cleanup waste while managing the Environmental Management Waste Management Facility (EMWMF); and provided operations, surveillance, and maintenance activities at DOE EM facilities at ETTP, ORNL, and the Y-12 National Security Complex. Project performance as of December 31, 2012 has been excellent: - Cost Performance Index - 1.06; - Schedule Performance Index - 1.02. At the same time, since safety is the foundation of all cleanup work, UCOR's safety record goes hand in hand with its excellent project performance. Through calendar year 2012, UCOR's recordable injury rate was 0.33, and the company has worked close to 4 million hours without a lost work day injury. UCOR's safety record is one of the best in the DOE EM Complex. This performance was due, in large part, to the people and processes URS and CH2M HILL, the parent companies of UCOR, brought to the project. Key approaches included: - Selected and deployed experienced staff in key leadership positions throughout the organization; - Approached 'Transition' as the 'true' beginning of the cleanup project - kicking off a number of project initiatives such as Partnering, PMB development, D and D Plan execution, etc. - Established a project baseline for performance measurement and obtained EVMS certification in record time; - Determined material differences and changed conditions that warranted contract change - then quickly addressed these changes with the DOE client; - Aligned the project and the contract within one year - also done in record time; - Implemented Safety Trained Supervisor and Safety Conscious Work Environment Programs, and kicked off the pursuit of certification under DOE's Voluntary Protection Program. (authors)« less

Southeast regional and state trends in anuran occupancy from calling survey data (2001-2013) from the North American Amphibian Monitoring Program

USGS Publications Warehouse

Villena Carpio, Oswaldo; Royle, J. Andrew; Weir, Linda; Foreman, Tasha M.; Gazenski, Kimberly D.; Campbell Grant, Evan H.

2016-01-01

We present the first regional trends in anuran occupancy for eight states of the southeastern United States, based on 13 y (2001–2013) of North American Amphibian Monitoring Program (NAAMP) data. The NAAMP is a longterm monitoring program in which observers collect anuran calling observation data at fixed locations along random roadside routes. We assessed occupancy trends for 14 species. We found weak evidence for a general regional pattern of decline in calling anurans within breeding habitats along roads in the southeastern USA over the last 13 y. Two species had positive regional trends with 95% posterior intervals that did not include zero (Hyla cinerea and Pseudacris crucifer). Five other species also showed an increasing trend, while eight species showed a declining trend, although 95% posterior intervals included zero. We also assessed state level trends for 107 species/state combinations. Of these, 14 showed a significant decline and 12 showed a significant increase in occupancy (i.e., credible intervals did not include zero for these 26 trends).

A historical perspective of the YF-12A thermal loads and structures program

NASA Technical Reports Server (NTRS)

Jenkins, Jerald M.; Quinn, Robert D.

1996-01-01

Around 1970, the Y-F-12A loads and structures efforts focused on numerous technological issues that needed defining with regard to aircraft that incorporate hot structures in the design. Laboratory structural heating test technology with infrared systems was largely created during this program. The program demonstrated the ability to duplicate the complex flight temperatures of an advanced supersonic airplane in a ground-based laboratory. The ability to heat and load an advanced operational aircraft in a laboratory at high temperatures and return it to flight status without adverse effects was demonstrated. The technology associated with measuring loads with strain gages on a hot structure was demonstrated with a thermal calibration concept. The results demonstrated that the thermal stresses were significant although the airplane was designed to reduce thermal stresses. Considerable modeling detail was required to predict the heat transfer and the corresponding structural characteristics. The overall YF-12A research effort was particularly productive, and a great deal of flight, laboratory, test and computational data were produced and cross-correlated.

Remedial Investigation Work Plan for Chestnut Ridge Operable Unit 1 (Chestnut Ridge Security Pits) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-03-01

This document outlines the activities necessary to conduct a Remedial Investigation (RI) of the Chestnut Ridge Security Pits (CRSP) at the Oak Ridge Y-12 Plant. The CRSP, also designated Chestnut Ridge Operable Unit (OU) 1, is one of four OUs along Chestnut Ridge on the Oak Ridge Reservation (ORR). The purpose of the RI is to collect data to (1) evaluate the nature and extent of known and suspected contaminants, (2) support an Ecological Risk Assessment (ERA) and a Human Health Risk Assessment (HHRA), (3) support the feasibility study in the development and analysis of remedial alternatives, and (4) ultimately,more » develop a Record of Decision (ROD) for the site. This chapter summarizes the regulatory background of environmental investigation on the ORR and the approach currently being followed and provides an overview of the RI to be conducted at the CRSP. Subsequent chapters provide details on site history, sampling activities, procedures and methods, quality assurance (QA), health and safety, and waste management related to the RI.« less

Molecular mechanisms of platelet P2Y(12) receptor regulation.

PubMed

Cunningham, Margaret R; Nisar, Shaista P; Mundell, Stuart J

2013-02-01

Platelets are critical for haemostasis, however inappropriate activation can lead to the development of arterial thrombosis, which can result in heart attack and stroke. ADP is a key platelet agonist that exerts its actions via stimulation of two surface GPCRs (G-protein-coupled receptors), P2Y(1) and P2Y(12). Similar to most GPCRs, P2Y receptor activity is tightly regulated by a number of complex mechanisms including receptor desensitization, internalization and recycling. In the present article, we review the molecular mechanisms that underlie P2Y(1) and P2Y(12) receptor regulation, with particular emphasis on the structural motifs within the P2Y(12) receptor, which are required to maintain regulatory protein interaction. The implications of these findings for platelet responsiveness are also discussed.

Environmental education: A blueprint for achievement?

DOE Office of Scientific and Technical Information (OSTI.GOV)

McErlean, A.J.; Williams, E.; Wittwer, F.

1995-09-01

The present national effort devoted to environmental education (EE), particularly as it relates to K-12 education, is examined and indexed to other current events and their support levels. For the most part, EE efforts are embedded in science, mathematics, and engineering programs (SME), and the relationships to these other areas are discussed. In the present context, many aspects such as social, ethical, and religious consideration of EE are not addressed. The relationships between EE and the expectation for scientific literacy (SL) and improved environmental decision-making in both short- and long-term contexts are also examined. Under existing programs, the prognosis formore » serious, effective accomplishment, or credible impact on universal EE literacy or enhanced decision-making, is doubtful.« less

Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995more » commitments.« less

Colonie Interim Storage Site annual environmental report for calendar year 1991, Colonie, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-09-01

This document describes the environmental monitoring program at the Colonie Interim Storage Site (CISS) and surrounding area, implementation of the program, and monitoring results for 1991. Environmental monitoring at CISS began in 1984 when Congress added the site to the US Department of Energy's Formerly Utilized Sites Remedial Action Program. CISS property and surrounding areas were radioactively contaminated by operations conducted by National Lead Industries, which manufactured various components from uranium and thorium from 1958 to 1984. The environmental monitoring program at CISS includes sampling networks for external gamma radiation exposure and for radium-226, thorium-232, and total uranium concentrations inmore » surface water, sediment, and groundwater. Additionally, several nonradiological parameters are measured in groundwater. In 1992 the program will also include sampling networks for radioactive and chemical contaminants in stormwater to meet permit application requirements under the Clean Water Act. Monitoring results are compared with applicable Environmental Protection Agency (EPA) standards, DOE derived concentration guides (DCGs), dose limits, and other requirements in DOE.orders. Environmental standards are established to protect public health and the environment. Results of environmental monitoring during 1991 indicate that average concentrations of radioactive contaminants of concern were well below applicable standards and DCGS. Concentrations of some chemical contaminants in groundwater were above-the New York State Department of Environmental Conservation (Class GA) and EPA guidelines for drinking water. The potential annual radiation exposure (excluding background) calculated for a hypothetical maximally exposed individual is 0.23 mrem (milliroentgen equivalent man), which is less than an individual would receive while traveling in an airplane at 12,000 meters (39,000 feet) for one hour.« less

EPA Collaboration with Mexico

EPA Pesticide Factsheets

EPA works with our Mexican neighbors on the U.S.-Mexico Environmental Program, a collaboration between the United States and Mexico to improve the environment and protect the health of the nearly 12 million people living along the border.

P2Y12 expression and function in alternatively activated human microglia

PubMed Central

Ase, Ariel R.; Kinsara, Angham; Rao, Vijayaraghava T.S.; Michell-Robinson, Mackenzie; Leong, Soo Yuen; Butovsky, Oleg; Ludwin, Samuel K.; Séguéla, Philippe; Bar-Or, Amit; Antel, Jack P.

2015-01-01

Objective: To investigate and measure the functional significance of altered P2Y12 expression in the context of human microglia activation. Methods: We performed in vitro and in situ experiments to measure how P2Y12 expression can influence disease-relevant functional properties of classically activated (M1) and alternatively activated (M2) human microglia in the inflamed brain. Results: We demonstrated that compared to resting and classically activated (M1) human microglia, P2Y12 expression is increased under alternatively activated (M2) conditions. In response to ADP, the endogenous ligand of P2Y12, M2 microglia have increased ligand-mediated calcium responses, which are blocked by selective P2Y12 antagonism. P2Y12 antagonism was also shown to decrease migratory and inflammatory responses in human microglia upon exposure to nucleotides that are released during CNS injury; no effects were observed in human monocytes or macrophages. In situ experiments confirm that P2Y12 is selectively expressed on human microglia and elevated under neuropathologic conditions that promote Th2 responses, such as parasitic CNS infection. Conclusion: These findings provide insight into the roles of M2 microglia in the context of neuroinflammation and suggest a mechanism to selectively target a functionally unique population of myeloid cells in the CNS. PMID:25821842

Determinant Factors of Long-Term Performance Development in Young Swimmers.

PubMed

Morais, Jorge E; Silva, António J; Marinho, Daniel A; Lopes, Vítor P; Barbosa, Tiago M

2017-02-01

To develop a performance predictor model based on swimmers' biomechanical profile, relate the partial contribution of the main predictors with the training program, and analyze the time effect, sex effect, and time × sex interaction. 91 swimmers (44 boys, 12.04 ± 0.81 y; 47 girls, 11.22 ± 0.98 y) evaluated during a 3-y period. The decimal age and anthropometric, kinematic, and efficiency features were collected 10 different times over 3 seasons (ie, longitudinal research). Hierarchical linear modeling was the procedure used to estimate the performance predictors. Performance improved between season 1 early and season 3 late for both sexes (boys 26.9% [20.88;32.96], girls 16.1% [10.34;22.54]). Decimal age (estimate [EST] -2.05, P < .001), arm span (EST -0.59, P < .001), stroke length (EST 3.82; P = .002), and propelling efficiency (EST -0.17, P = .001) were entered in the final model. Over 3 consecutive seasons young swimmers' performance improved. Performance is a multifactorial phenomenon where anthropometrics, kinematics, and efficiency were the main determinants. The change of these factors over time was coupled with the training plans of this talent identification and development program.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) persistence in the Seveso (Milan, Italy) soil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cerlesi, S.; Di Domenico, A.; Ratti, S.

1989-10-01

Preliminary results of a new study on TCDD environmental persistence at Seveso (Milan, Italy) are presented. For this study, the most contaminated territory, Zone A, was divided into areas to fractionate the available TCDD levels in soil into data sets with reduced value spreads. In addition, various time subsets were defined for each area. Selected data were fitted with the exponential model y = y0.e-k.1. It was estimated that at least 1.2 kg TCDD was present in Zone A shortly after the accident. On average, a considerable portion (23%) of this amount lay on vegetation; TCDD which was not photodegradedmore » or volatilized before the heavy rains of fall 1976, was later washed off and transferred to ground by water action. From this study, mean analytical underestimations affecting January 1977 and March 1978 contamination map data were on the order of 30 and 24%. All the above figures are considered optimistic. A few years after the accident, mean TCDD half-life in soil appeared to be 9.1y (t1/2-95% CLs, 6.2-17y).« less

Supersonic Plasma Spray Deposition of CoNiCrAlY Coatings on Ti-6Al-4V Alloy

NASA Astrophysics Data System (ADS)

Caliari, F. R.; Miranda, F. S.; Reis, D. A. P.; Essiptchouk, A. M.; Filho, G. P.

2017-06-01

Plasma spray is a versatile technology used for production of environmental and thermal barrier coatings, mainly in the aerospace, gas turbine, and automotive industries, with potential application in the renewable energy industry. New plasma spray technologies have been developed recently to produce high-quality coatings as an alternative to the costly low-pressure plasma-spray process. In this work, we studied the properties of as-sprayed CoNiCrAlY coatings deposited on Ti-6Al-4V substrate with smooth surface ( R a = 0.8 μm) by means of a plasma torch operating in supersonic regime at atmospheric pressure. The CoNiCrAlY coatings were evaluated in terms of their surface roughness, microstructure, instrumented indentation, and phase content. Static and dynamic depositions were investigated to examine their effect on coating characteristics. Results show that the substrate surface velocity has a major influence on the coating properties. The sprayed CoNiCrAlY coatings exhibit low roughness ( R a of 5.7 μm), low porosity (0.8%), excellent mechanical properties ( H it = 6.1 GPa, E it = 155 GPa), and elevated interface toughness (2.4 MPa m1/2).

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.

PubMed

Caroff, Eva; Hubler, Francis; Meyer, Emmanuel; Renneberg, Dorte; Gnerre, Carmela; Treiber, Alexander; Rey, Markus; Hess, Patrick; Steiner, Beat; Hilpert, Kurt; Riederer, Markus A

2015-12-10

Recent post hoc analyses of several clinical trials with P2Y12 antagonists showed the need for new molecules being fully efficacious as antiplatelet agents and having a reduced propensity to cause major bleeding. We have previously reported the discovery of the 2-phenylpyrimidine-4-carboxamide analogs as P2Y12 antagonists with nanomolar potency in the disease-relevant platelet aggregation assay in human plasma. Herein we present the optimization steps that led to the discovery of clinical candidate ACT-246475 (30d). The key step was the replacement of the carboxylic acid functionality by a phosphonic acid group which delivered the most potent molecules of the program. In addition, low in vivo clearance in rat and dog was achieved for the first time. Since the bioavailability of 30d was low in rat and dog, we developed the bis((isopropoxycarbonyl)oxy)methyl ester prodrug (ACT-281959, 45). Compound 30d showed efficacy in the rat ferric chloride thrombosis model when administered intravenously as parent or orally as its prodrug 45. Moreover, 30d displays a wider therapeutic window as compared to clopidogrel in the rat surgical blood loss model.

Ecotourism, sustainable development, and conservation education: Development of a tour guide training program in Tortuguero, Costa Rica

NASA Astrophysics Data System (ADS)

Jacobson, Susan K.; Robles, Rafael

1992-11-01

A tour guide training program was developed for rural communities near Costa Rica's Tortuguero National Park to respond to the impacts of the 24-fold increase in park visitation in the past decade, to involve local communities in resource management, and to provide regional environmental education. The development of the training course involved a survey of scientists and park managers to ascertain resource management needs, priorities for information to be disseminated, and impacts of tourism on the resource base. Current and potential tour guides were surveyed to identify their information needs, solicit their input in the training program, and to determine their knowledge and skills. Written questionnaires were developed and given to 400 tourists to determine their activities and environmental information needs, and hotel owners were censused to examine the economic feasibility of a local guide program. A pilot training course and guide program involving 12 Tortuguero residents demonstrated that a tour guide program: (1) helped mitigate negative tourism impacts on Tortuguero National Park's natural resources, particularly by regulating tourists on the park's 35-km beach used for nesting by endangered sea turtles; (2) provided environmental education to an important segment of the local community not traditionally reached through school or government development projects; (3) provided environmental information to tourists, thus enhancing their visit; and (4) provided local economic benefits through lucrative part-time employment, thereby allowing local people to participate more fully in the tourism system. An extended training course is being planned to provide further environmental education programming and to increase year-round employment opportunities for the tour guides.

All Candidates

Science.gov Websites

1.193 1.46 SN Ia c Y Y Y SCP06B3 Isabella 0.743 1.12 SN CC c Y Y SCP06B4 Michaela 1.116 1.12 Y SN CC c Y Y SCP06C0 Noa 1.092 0.97 SN Ia b,c Y Y SCP06C1 Midge 0.98 0.97 Y SN Ia a,c Y Y Y SCP06C7 0.61 0.97 SN CC c Y Y SCP06C50 0.97 SCP05D0 Frida 1.014 1.02 Y SN Ia a,b,c Y Y Y SCP05D6 Maggie 1.314 1.02 SN

Pathways: a culturally appropriate obesity-prevention program for American Indian schoolchildren1–3

PubMed Central

Davis, Sally M; Going, Scott B; Helitzer, Deborah L; Teufel, Nicolette I; Snyder, Patricia; Gittelsohn, Joel; Metcalfe, Lauve; Arviso, Vivian; Evans, Marguerite; Smyth, Mary; Brice, Richard; Altaha, Jackie

2016-01-01

Pathways, a culturally appropriate obesity prevention study for third-, fourth-, and fifth-grade American Indian schoolchildren includes an intervention that promotes increased physical activity and healthful eating behaviors. The Pathways intervention, developed through a collaboration of universities and American Indian nations, schools, and families, focuses on individual, behavioral, and environmental factors and merges constructs from social learning theory with American Indian customs and practices. We describe the Pathways program developed during 3 y of feasibility testing in American Indian schools, with special emphasis on the activities developed for the third grade; review the theoretical and cultural underpinnings of the program; outline the construction process of the intervention; detail the curriculum and physical education components of the intervention; and summarize the formative assessment and the school food service and family components of the intervention. PMID:10195605

P2Y12 shRNA treatment decreases SGC activation to relieve diabetic neuropathic pain in type 2 diabetes mellitus rats.

PubMed

Wang, Shouyu; Wang, Zilin; Li, Lin; Zou, Lifang; Gong, Yingxin; Jia, Tianyu; Zhao, Shanhong; Yuan, Huilong; Shi, Liran; Liu, Shuangmei; Wu, Bing; Yi, Zhihua; Liu, Hui; Gao, Yun; Li, Guilin; Deussing, Jan M; Li, Man; Zhang, Chunping; Liang, Shangdong

2018-06-26

Diabetic neuropathic pain is a common complication of type 2 diabetes mellitus (DM). Activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) plays a crucial role in neuropathic pain through the release of proinflammatory cytokines. The P2Y12 receptor is expressed in SGCs of the DRG. In this study, our aim was to investigate the role of the P2Y12 receptor on the pathological changes in diabetic neuropathic pain. The present study showed that diabetic neuropathic pain increased mechanical and thermal hyperalgesia in type 2 DM model rats. The results showed that the expression levels of P2Y12 messenger RNA (mRNA) and protein in DRG SGCs were increased in DM model rats compared with control rats. Glial fibrillary acidic protein (GFAP) and interleukin-1β (IL-1β) expression levels in the DRG were increased in DM rats. Upregulation of GFAP is a marker of SGC activation. Targeting the P2Y12 receptor by short hairpin RNA (shRNA) decreased the upregulated expression of P2Y12 mRNA and protein, coexpression of P2Y12 and GFAP, the expression of GFAP, IL-1β, and tumor necrosis factor-receptor 1 in the DRG of DM rats, and relieved mechanical and thermal hyperalgesia in DM rats. After treatment with the P2Y12 receptor shRNA, the enhancing integrated OPTICAL density (IOD) ratios of p-P38 MAPK to P38 mitogen activated protein kinase (MAPK) in the DM rats treated with P2Y12 shRNA were significantly lower than that in the untreated DM rats. Therefore, P2Y12 shRNA treatment decreased SGC activation to relieve mechanical and thermal hyperalgesia in DM rats. © 2018 Wiley Periodicals, Inc.

Programme for Environmental Studies, Red Sea and Gulf of Aden, Jeddah II Conference, 12-18 January 1976. Provisional Report.

ERIC Educational Resources Information Center

Arab Organization for Education and Science, Cairo (Egypt).

This publication presents the report of Jeddah II Conference of the Program for Environmental Studies, Red Sea and Gulf of Aden (PERSGA) hosted by King Abdul Aziz University in Jeddah in January 1976. The Arab League Educational, Cultural and Scientific Organization (ALECSO) initiated the conference to study the issues of scientific research on,…

The Garbage Gospel: Using the Theory of Planned Behavior to Explain the Role of Religious Institutions in Affecting Pro-Environmental Behavior among Ethnic Minorities

ERIC Educational Resources Information Center

Lakhan, Calvin

2018-01-01

This study used Azjen's Theory of Planned Behavior to examine how pro-recycling and pro-environmental messaging delivered by religious leaders affects stated recycling behavior among ethnic minorities. Using data collected from 12 religious institutions in three Ontario, Canada, communities, a promotion and education program was developed to: (1)…

Tested, Trusted, Yet Frustrating: An Investigation into the Effectiveness of Environmental Radio Jingles in Oyo State Nigeria

ERIC Educational Resources Information Center

Ojebode, Ayo

2005-01-01

Radio stations have used jingles for environmental education and communication in Nigeria for decades though not much has been done to study the impact of such use--which is the purpose of this article. Through 12 focus group discussions (FGDs) in six local government areas of Oyo state, Nigeria, interviews with the program directors of two radio…

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.

PubMed

Nisar, Shaista; Daly, Martina E; Federici, Augusto B; Artoni, Andrea; Mumford, Andrew D; Watson, Stephen P; Mundell, Stuart J

2011-11-17

The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putative postsynaptic density 95/disc large/zonula occludens-1 (PDZ)-binding motif. In cell line models, removal of this sequence or mutation of one of its core residues (P341A), attenuates receptor internalization and receptor recycling back to the membrane, thereby blocking receptor resensitization. The physiologic significance of these findings in the regulation of platelet function is shown by identification of a patient with a heterozygous mutation in the PDZ binding sequence of their P2Y(12)R (P341A) that is associated with reduced expression of the P2Y(12)R on the cell surface. Importantly, platelets from this subject showed significantly compromised P2Y(12)R recycling, emphasizing the importance of the extreme C-terminus of this receptor to ensure correct receptor traffic.

The climate adaptation programs and activities of the Yellowstone to Yukon Conservation Initiative

Treesearch

Wendy L. Francis

2011-01-01

The Yellowstone to Yukon Conservation Initiative (Y2Y) is an innovative transboundary effort to protect biodiversity and facilitate climate adaptation by linking large protected core areas through compatible land uses on matrix lands. The Y2Y organization acts as the keeper of the Y2Y vision and implements two interconnected programs - Science and Action, and Vision...

PAN AIR - A Computer Program for Predicting Subsonic or Supersonic Linear Potential Flows about Arbitrary Configurations Using a Higher Order Panel Method. Volume I. Theory Document (Version 1.0)

DTIC Science & Technology

1980-04-15

superinclined panel J.12-12 J.20 Transformation to (s,t) variables and region of integration J.12-13 J.21 Numbering of edges of ’n Hh J.12-13 J.22 A region... JB . 4.12d((C-x) 2+(n-y)2+(ý-z)2)i) (8.4.12) we have • (P) ij 0 (8.4.13) if i+j is even, and i+j > 0. Let us now consider the velocity OD Pij I1 4...came from, since we did not arrive at A through a rigorous procedure. Recall that we claim that AT I [CO] r [Co] o n’o I~~ I, )T-- hh )1T (E.3.16a

Assessment of the U. S. outer continental shelf environmental studies program. 1. Physical oceanography. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Federal responsibility for oil and gas development on the U.S. outer continental shelf (OCS) resides with the Minerals Management Service (MMS) of the U.S. Department of the Interior (DOI). The DOI's Environmental Studies Program (ESP) is the program through which MMS conducts environmental studies on the OCS and collects information to prepare environmental impact statements (EISs). It appeared to MMS in 1986 that the time was ripe to assess the status of the present program and to explore the needs for future studies. MMS requested an evaluation of the adequacy and applicability of ESP studies, a review of the generalmore » state of knowledge in the appropriate disciplines, and recommendations for future studies. Three panels were established, one of which, the Physical Oceanography Panel, investigated the physical oceanographic aspects of the ESP, the subject of the report, which is the first of three in a series. In reviewing the ESP's physical oceanography program, the panel evaluated the quality and relevance of studies carried out in waters under federal control, which extend from the limits of state jurisdictions (3-12 miles offshore) and include the central and outer continental shelf waters and the continental slope.« less

40 CFR 35.101 - Environmental programs covered by the subpart.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Stat. 1344, 1373 (1997)). (2) Air pollution control (section 105 of the Clean Air Act). (3) Water... Control Act). (12) State indoor radon grants (section 306 of the Toxic Substances Control Act). (13) Toxic...

Migration of Hazardous Substances through Soil. Part 4. Development of a Serial Batch Extraction Method and Application to the Accelerated Testing of Seven Industrial Wastes

DTIC Science & Technology

1987-09-01

Evaluation Commnand &_. ADMASS Coly, 1W~., and ZIP Code ) 7b. ADDRESS (C01y, State, wid ZIP Code ) Dugwiay, Utahi 84022-5000 Aberdeen Proving Ground...Aency_________________________ 9L AoOMS(CRY, 0to, and ZIP Code ) 10. SOURCE OF FUNDING NUMBERS Hazardous Waste Environmental RLsearch Lab PROGRAM PROJECT TASK...CLASSIFICATION 0 UNO.ASSIFIEDAIJNLIMITED 0l SAME AS RPT. 03 OTIC USERS UNCLA.SSIFIED 22a. RAWE OF RESPONSIBLE INDIVIDUAL 22b TELEPHONE (Include Area Code ) I

Energy Efficiency Programs in K-12 Schools: A Guide to Developing and Implementing Greenhouse Gas Reduction Programs. Local Government Climate and Energy Strategy Series

ERIC Educational Resources Information Center

US Environmental Protection Agency, 2011

2011-01-01

Saving energy through energy efficiency improvements can cost less than generating, transmitting, and distributing energy from power plants, and provides multiple economic and environmental benefits. Local governments can promote energy efficiency in their jurisdictions by developing and implementing strategies that improve the efficiency of…

To Determine the Effectiveness of Board Game Simulations in the Grade Five Social Studies Program. Final Report 80-7.

ERIC Educational Resources Information Center

Green, Vicki A.

The report describes a study designed to ascertain the effectiveness of 12 board game simulations developed and used in a fifth grade Canadian history program. Questions examined include: 1) Does the use of board game simulations increase group participation and cultural, environmental, and historical awareness? 2) Does use of the games promote…

Effectiveness of home exercise on pain, function, and strength of manual wheelchair users with spinal cord injury: a high-dose shoulder program with telerehabilitation.

PubMed

Van Straaten, Meegan G; Cloud, Beth A; Morrow, Melissa M; Ludewig, Paula M; Zhao, Kristin D

2014-10-01

To test the effectiveness of a high-dose home exercise/telerehabilitation program for manual wheelchair users who have a spinal cord injury (SCI) by determining whether the intervention would reduce pain and increase function, as we hypothesized. A pre-post trial with outcomes measured at 3 time points: baseline, postintervention (12wk), and follow-up (>24 wk). Subjects performed an exercise program at their homes using telerehabilitation for therapist monitoring of technique and exercise advancement. Baseline and postintervention data were collected at a motion analysis laboratory in a tertiary medical center. A convenience sample of manual wheelchair users (N=16, 3 women; average age, 41y; average time in a wheelchair, 16y) with shoulder pain (average pain duration, 9y) and mechanical impingement signs on physical examination. A 12-week home exercise program of rotator cuff and scapular stabilization exercises was given to each participant. The program included a high dose of 3 sets of 30 repetitions, 3 times weekly, and regular physical therapist supervision via videoconferencing. Primary outcomes of pain and function were measured with the Wheelchair User's Shoulder Pain Index (WUSPI), Disabilities of Arm, Shoulder, and Hand (DASH) Index, and Shoulder Rating Questionnaire (SRQ). Secondary outcomes of strength were measured with isometric strength tests of scapulothoracic and glenohumeral muscles, and a static fatigue test of the lower trapezius. Pain was reduced and function improved after the intervention. There was a significant main effect for pain and function between the 3 time points based on the Friedman signed-ranked test, WUSPI (χ(2)2=5.10, P=.014), DASH Index (χ(2)2=5.41, P=.012), and SRQ (χ(2)2=23.71, P≤.001). Wilcoxon signed-rank tests demonstrated that isometric strength measurements of the serratus anterior and scapular retractors increased after the exercise intervention ([t=2.42, P=.04] and [t=4.67, P=.003], respectively). Muscle impulse produced by the lower trapezius during a fatigue task also improved (t=2.2, P=.02). No differences were measured in isometric strength for the lower trapezius, glenohumeral rotators, and abductors between the baseline and 12-week time points. A high-dose scapular stabilizer and rotator cuff strengthening program using telerehabilitation for supervision holds promise for shoulder pain treatment in manual wheelchair users with SCI. Additional work is needed to determine the effectiveness compared with other interventions, as well as the potential for earlier intervention to prevent development of shoulder pain. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Large-scale climatic phenomena drive fluctuations in macroinvertebrate assemblages in lowland tropical streams, Costa Rica: The importance of ENSO events in determining long-term (15y) patterns

PubMed Central

Ramírez, Alonso; Pringle, Catherine M.

2018-01-01

Understanding how environmental variables influence the distribution and density of organisms over relatively long temporal scales is a central question in ecology given increased climatic variability (e.g., precipitation, ENSO events). The primary goal of our study was to evaluate long-term (15y time span) patterns of climate, as well as environmental parameters in two Neotropical streams in lowland Costa Rica, to assess potential effects on aquatic macroinvertebrates. We also examined the relative effects of an 8y whole-stream P-enrichment experiment on macroinvertebrate assemblages against the backdrop of this long-term study. Climate, environmental variables and macroinvertebrate samples were measured monthly for 7y and then quarterly for an additional 8y in each stream. Temporal patterns in climatic and environmental variables showed high variability over time, without clear inter-annual or intra-annual patterns. Macroinvertebrate richness and abundance decreased with increasing discharge and was positively related to the number of days since the last high discharge event. Findings show that fluctuations in stream physicochemistry and macroinvertebrate assemblage structure are ultimately the result of large-scale climatic phenomena, such as ENSO events, while the 8y P-enrichment did not appear to affect macroinvertebrates. Our study demonstrates that Neotropical lowland streams are highly dynamic and not as stable as is commonly presumed, with high intra- and inter-annual variability in environmental parameters that change the structure and composition of freshwater macroinvertebrate assemblages. PMID:29420548

How Do Sustainable Schools Integrate Sustainability Education? An Assessment of Certified Sustainable K-12 Schools in the United States

ERIC Educational Resources Information Center

Warner, Benjamin P.; Elser, Monica

2015-01-01

We provide an overview of research in sustainability education. We argue that the interconnectedness of environmental sustainability programs at K-12 schools is one metric by which sustainability education can be conceptualized. We present a new measure of whole-school sustainability, or "interconnectedness," and then use it to compare…

2006 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

2008-04-17

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

2009 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

2010-07-09

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

2008 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

2009-12-11

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

2010 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

2011-08-31

The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

2007 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

2009-07-01

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

Laterally Loaded Partially Prestressed Concrete Piles

DTIC Science & Technology

1989-09-01

of an extensive test program onl laterali y ioadeu. partially pr- estressed concrete fender piles. The study Included service load range as well ats...12,000-psi design strength). Configura- tion G utilized 14 r:- estress strand, in an unsymmetric pattern. To provide a uniform concrete prestress of 540...sudden loss in load carrying capacity directly related to the loss of concrete area. The compression concrete fractured longitudinally and along the

Characterization of a New Pink-Fruited Tomato Mutant Results in the Identification of a Null Allele of the SlMYB12 Transcription Factor.

PubMed

Fernandez-Moreno, Josefina-Patricia; Tzfadia, Oren; Forment, Javier; Presa, Silvia; Rogachev, Ilana; Meir, Sagit; Orzaez, Diego; Aharoni, Aspah; Granell, Antonio

2016-07-01

The identification and characterization of new tomato (Solanum lycopersicum) mutants affected in fruit pigmentation and nutritional content can provide valuable insights into the underlying biology, as well as a source of new alleles for breeding programs. To date, all characterized pink-pigmented tomato fruit mutants appear to result from low SlMYB12 transcript levels in the fruit skin. Two new mutant lines displaying a pink fruit phenotype (pf1 and pf2) were characterized in this study. In the pf mutants, SlMYB12 transcripts accumulated to wild-type levels but exhibited the same truncation, which resulted in the absence of the essential MYB activation domain coding region. Allelism and complementation tests revealed that both pf mutants were allelic to the y locus and showed the same recessive null allele in homozygosis: Δy A set of molecular and metabolic effects, reminiscent of those observed in the Arabidopsis (Arabidopsis thaliana) myb11 myb12 myb111 triple mutant, were found in the tomato Δy mutants. To our knowledge, these have not been described previously, and our data support the idea of their being null mutants, in contrast to previously described transcriptional hypomorphic pink fruit lines. We detected a reduction in the expression of several flavonol glycosides and some associated glycosyl transferases. Transcriptome analysis further revealed that the effects of the pf mutations extended beyond the flavonoid pathway into the interface between primary and secondary metabolism. Finally, screening for Myb-binding sites in the candidate gene promoter sequences revealed that 141 of the 152 co-down-regulated genes may be direct targets of SlMYB12 regulation. © 2016 American Society of Plant Biologists. All Rights Reserved.

Divergence in morphology, but not habitat use, despite low genetic differentiation among insular populations of the lizard Anolis lemurinus in Honduras

USGS Publications Warehouse

Logan, M.L.; Montgomery, Chad E.; Boback, Scott M.; Reed, R.N.; Campbell, J.A.

2012-01-01

Studies of recently isolated populations are useful because observed differences can often be attributed to current environmental variation. Two populations of the lizard Anolis lemurinus have been isolated on the islands of Cayo Menor and Cayo Mayor in the Cayos Cochinos Archipelago of Honduras for less than 15 000 y. We measured 12 morphometric and 10 habitat-use variables on 220 lizards across these islands in 2 y, 2008 and 2009. The goals of our study were (1) to explore patterns of sexual dimorphism, and (2) to test the hypothesis that differences in environment among islands may have driven divergence in morphology and habitat use despite genetic homogeneity among populations. Although we found no differences among sexes in habitat use, males had narrower pelvic girdles and longer toe pads on both islands. Between islands, males differed in morphology, but neither males nor females differed in habitat use. Our data suggest that either recent selection has operated differentially on males despite low genetic dill'erentiation, or that they display phenotypic plasticity in response to environmental variation. We suggest that patterns may be driven by variation in intrapopulation density or differences in predator diversity among islands.

CHARACTERIZATION OF H-Y AND CR-Y ZEOLITE CATALYSTS DURING THE OXIDATIVE DESTRUCTION OF CFC11 AND CFC12

EPA Science Inventory

The long term stability-deactivation characteristics of two Y zeolite catalysts, namely H-Y and cation exchanged Cr-Y, were studied during the oxidative destruction of CFC11 and CFC12 feeds. Experiments were carried out at 300 degrees C and 500 h-1 space velocity. Properties of...

Tissue kallikrein induces SH-SY5Y cell proliferation via epidermal growth factor receptor and extracellular signal-regulated kinase1/2 pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Zhengyu; Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437; Yang, Qi

2014-03-28

Highlights: • TK promotes EGFR phosphorylation in SH-SY5Y cells. • TK activates ERK1/2 and p38 phosphorylation in SH-SY5Y cells. • TK mediates SH-SY5Y cell proliferation via EGFR and ERK1/2 pathway. - Abstract: Tissue kallikrein (TK) is well known to take most of its biological functions through bradykinin receptors. In the present study, we found a novel signaling pathway mediated by TK through epidermal growth factor receptor (EGFR) in human SH-SY5Y cells. We discovered that TK facilitated the activation of EGFR, extracellular signal-regulated kinase (ERK) 1/2 and p38 cascade. Interestingly, not p38 but ERK1/2 phosphorylation was severely compromised in cells depletedmore » of EGFR. Nevertheless, impairment of signaling of ERK1/2 seemed not to be restricted to EGFR phosphorylation. We also observed that TK stimulation could induce SH-SY5Y cell proliferation, which was reduced by EGFR down-regulation or ERK1/2 inhibitor. Overall, our findings provided convincing evidence that TK could mediate cell proliferation via EGFR and ERK1/2 pathway in vitro.« less

Final Environmental Impact Statement (EIS) for the Space Nuclear Thermal Propulsion (SNTP) program

NASA Astrophysics Data System (ADS)

1991-09-01

A program has been proposed to develop the technology and demonstrate the feasibility of a high-temperature particle bed reactor (PBR) propulsion system to be used to power an advanced second stage nuclear rocket engine. The purpose of this Final Environmental Impact Statement (FEIS) is to assess the potential environmental impacts of component development and testing, construction of ground test facilities, and ground testing. Major issues and goals of the program include the achievement and control of predicted nuclear power levels; the development of materials that can withstand the extremely high operating temperatures and hydrogen flow environments; and the reliable control of cryogenic hydrogen and hot gaseous hydrogen propellant. The testing process is designed to minimize radiation exposure to the environment. Environmental impact and mitigation planning are included for the following areas of concern: (1) Population and economy; (2) Land use and infrastructure; (3) Noise; (4) Cultural resources; (5) Safety (non-nuclear); (6) Waste; (7) Topography; (8) Geology; (9) Seismic activity; (10) Water resources; (11) Meteorology/Air quality; (12) Biological resources; (13) Radiological normal operations; (14) Radiological accidents; (15) Soils; and (16) Wildlife habitats.

Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma.

PubMed

Wen, Bing; Fu, Feixian; Hu, Liangbo; Cai, Qiuyi; Xie, Junshi

2018-05-01

The aim of this study is to clarify the association between subventricular zone (SVZ) involvement and velocity of diametric expansion(VDE) in patients with low-grade astrocytoma and also assessed the clinical outcome of those patients. A total of 168 adult patients with newly diagnosed supratentorial low-grade astrocytoma were studied retrospectively. There were 73 patients had SVZ involvement. Patients with SVZ involvement(7.16 ± 6.53 mm/y) had a higher VDE than patients without SVZ involvement(4.38 ± 5.35 mm/y). VDE was modeled as a categorical variable(＜4, ≥4 and, ＜8, ≥8 and, ＜12, ≥12 mm/y). Logistic regression showed that SVZ involvement was associated with high VDE after adjusting by confounding variables. On the univariate analysis, the results showed that tumor involved with SVZ, VDE ≥ 4 mm/y, VDE ≥ 8 mm/y, and VDE ≥ 8 mm/y were significant predictors of a shorter OS, progression-free survival (PFS) and malignant progression-free survival (MFS)(all p ＜0.05). The categorical variables of VDE (＜4 mm/y, ≥4 mm/y and, ＜8 mm/y, ≥8 mm/y and, ＜12 mm/y, ≥12 mm/y) were adjusted by confounding variables in multivariate analysis, respectively. The results indicated that VDE ≥ 8 mm/y, VDE ≥ 12 mm/y were worse prognostic factors for OS, while VDE ≥ 4 mm/y, VDE ≥ 8 mm/y and VDE ≥ 12 mm/y were related to shorter PFS and MFS. In addition, SVZ involvement was prognostic factors in predicting OS and PFS except MFS. Our results demonstrated that SVZ involvement predicted high VDE and worse clinical outcome, and high VDE was associated with poor prognosis in patients with low-grade astrocytoma. Copyright © 2018 Elsevier B.V. All rights reserved.

High-speed resistance training is more effective than low-speed resistance training to increase functional capacity and muscle performance in older women.

PubMed

Ramírez-Campillo, Rodrigo; Castillo, Angélica; de la Fuente, Carlos I; Campos-Jara, Christian; Andrade, David C; Álvarez, Cristian; Martínez, Cristian; Castro-Sepúlveda, Mauricio; Pereira, Ana; Marques, Mário C; Izquierdo, Mikel

2014-10-01

To examine the effects of 12 weeks of high-speed resistance training (RT) versus low-speed RT on muscle strength [one repetition of maximum leg-press (1RMLP) and bench-press (1RMBP), plus dominant (HGd) and non-dominant maximum isometric handgrip], power [counter-movement jump (CMJ), ball throwing (BT) and 10-m walking sprint (S10)], functional performance [8-foot up-and-go test (UG) and sit-to-stand test (STS)], and perceived quality of life in older women. 45 older women were divided into a high-speed RT group [EG, n=15, age=66.3±3.7y], a low-speed RT group [SG, n=15, age=68.7±6.4y] and a control group [CG, n=15, age=66.7±4.9y]. The SG and EG were submitted to a similar 12-week RT program [3 sets of 8 reps at 40-75% of the one-repetition maximum (1

76 FR 44605 - Alaska Region's Subsistence Resource Commission (SRC) Program; Public Meeting and Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... Uses of Bones, Horn, Antlers and Plants Environmental Assessment Update. 12. New Business. 13. Public... Board Update. 10. Alaska Board of Game Update. 11. Old Business: a. Subsistence Uses of Bones, Horn...

ALIENS IN WESTERN STREAM ECOSYSTEMS

EPA Science Inventory

The USEPA's Environmental Monitoring and Assessment Program conducted a five year probability sample of permanent mapped streams in 12 western US states. The study design enables us to determine the extent of selected riparian invasive plants, alien aquatic vertebrates, and some ...

7 CFR 2.17 - Under Secretary for Rural Development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... economic, social, and environmental research and analysis, statistical programs, and associated service...; rural population and manpower; local government finance; income development strategies; housing; social... activities. (12) Assist other Federal agencies in formulating manpower development and training policies. (13...

7 CFR 2.17 - Under Secretary for Rural Development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... economic, social, and environmental research and analysis, statistical programs, and associated service...; rural population and manpower; local government finance; income development strategies; housing; social... activities. (12) Assist other Federal agencies in formulating manpower development and training policies. (13...

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

PubMed Central

Nisar, Shaista; Daly, Martina E.; Federici, Augusto B.; Artoni, Andrea; Mumford, Andrew D.; Watson, Stephen P.

2011-01-01

The platelet P2Y12 purinoceptor (P2Y12R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y12R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putative postsynaptic density 95/disc large/zonula occludens-1 (PDZ)–binding motif. In cell line models, removal of this sequence or mutation of one of its core residues (P341A), attenuates receptor internalization and receptor recycling back to the membrane, thereby blocking receptor resensitization. The physiologic significance of these findings in the regulation of platelet function is shown by identification of a patient with a heterozygous mutation in the PDZ binding sequence of their P2Y12R (P341A) that is associated with reduced expression of the P2Y12R on the cell surface. Importantly, platelets from this subject showed significantly compromised P2Y12R recycling, emphasizing the importance of the extreme C-terminus of this receptor to ensure correct receptor traffic. PMID:21937696

Pollution Prevention in Air Force System Acquisition Programs

DTIC Science & Technology

1994-09-01

Audits Number of Facility Audits 12. Chemical Spill Prevention Measures Number of Measures 13. Unresolved Notices of Violation Number of Open Notices...14. Air Force Environmental Audit Findings Number of Open Findings 15. Awareness / Information Tools Number of New Tools 16. Environmental Training...building thirty-six aircraft (FY94 budget) to be delivered in 1995-1996. The latest audited cost data that can be used in the negotiations ends in

The 2-MEV Scale in the United States: A Measure of Children's Environmental Attitudes Based on the Theory of Ecological Attitude

ERIC Educational Resources Information Center

Johnson, Bruce; Manoli, Constantinos C.

2011-01-01

The Environmental (2-MEV) Scale questionnaire was developed in Europe to measure adolescents' attitudes and gauge the effectiveness of educational programs. It also formed the basis for the Theory of Ecological Attitudes. In the present four-year study, the 2-MEV Scale was modified for use with 9-12-year-old children in the United States. Initial…

Mutal Admittance Between Slots on a Cylinder or Cone

DTIC Science & Technology

1977-12-01

a voltage V1 and slot 2 is short-circuited. An alternative expression for Y is 12 Y 1 l Ft 2 x2 t1, d2 (2.9) Y12 "V’ 2 A2 .2 where A2 a aperture of...2.9) are equivalent [1]. There is an alternative definition of mutual admittance. Instead of (2.7), a modal voltageV1 (with a bar) may be defined...domain. An alternative calculation of Y12 involves the field in the spatial domain, namely, Circumferential slots Y A A2 dY2dz2 [cos a o 2 - R 0)]go(s

Disparities in children's vocabulary and height in relation to household wealth and parental schooling: A longitudinal study in four low- and middle-income countries.

PubMed

Reynolds, Sarah A; Andersen, Chris; Behrman, Jere; Singh, Abhijeet; Stein, Aryeh D; Benny, Liza; Crookston, Benjamin T; Cueto, Santiago; Dearden, Kirk; Georgiadis, Andreas; Krutikova, Sonya; Fernald, Lia C H

2017-12-01

Children from low socio-economic status (SES) households often demonstrate worse growth and developmental outcomes than wealthier children, in part because poor children face a broader range of risk factors. It is difficult to characterize the trajectories of SES disparities in low- and middle-income countries because longitudinal data are infrequently available. We analyze measures of children's linear growth (height) at ages 1, 5, 8 and 12y and receptive language (Peabody Picture Vocabulary Test) at ages 5, 8 and 12y in Ethiopia, India, Peru and Vietnam in relation to household SES, measured by parental schooling or household assets. We calculate children's percentile ranks within the distributions of height-for-age z-scores and of age- and language-standardized receptive vocabulary scores. We find that children in the top quartile of household SES are taller and have better language performance than children in the bottom quartile; differences in vocabulary scores between children with high and low SES are larger than differences in the height measure. For height, disparities in SES are present by age 1y and persist as children age. For vocabulary, SES disparities also emerge early in life, but patterns are not consistent across age; for example, SES disparities are constant over time in India, widen between 5 and 12y in Ethiopia, and narrow in this age range in Vietnam and Peru. Household characteristics (such as mother's height, age, and ethnicity), and community fixed effects explain most of the disparities in height and around half of the disparities in vocabulary. We also find evidence that SES disparities in height and language development may not be fixed over time, suggesting opportunities for policy and programs to address these gaps early in life.

[Assessment of a residency training program in endocrinology and nutrition by physicians: results of a survey].

PubMed

Moreno-Fernández, Jesús; Gutiérrez-Alcántara, Carmen; Palomares-Ortega, Rafael; García-Manzanares, Alvaro; Benito-López, Pedro

2011-12-01

The current training program for resident physicians in endocrinology and nutrition (EN) organizes their medical learning. Program evaluation by physicians was assessed using a survey. The survey asked about demographic variables, EN training methods, working time and center, and opinion on training program contents. Fifty-one members of Sociedad Castellano-Manchega de Endocrinología, Nutrición y Diabetes, and Sociedad Andaluza de Endocrinología y Nutrición completed the survey. Forty-percent of them disagreed with the compulsory nature of internal medicine, cardiology, nephrology and, especially, neurology rotations (60%); a majority (>50%) were against several recommended rotations included in the program. The fourth year of residence was considered by 37.8% of respondents as the optimum time for outpatient and inpatient control and monitoring without direct supervision. The recommended monthly number of on-call duties was 3.8±1.2. We detected a positive opinion about extension of residence duration to 4.4±0.5 years. Doctoral thesis development during the residence period was not considered convenient by 66.7% of physicians. Finally, 97.8% of resident physicians would recommend residency in EN to other colleagues. Endocrinologists surveyed disagreed with different training program aspects such as the rotation system, skill acquisition timing, and on-call duties. Therefore, an adaptation of the current training program in EN would be required. Copyright © 2011 SEEN. Published by Elsevier Espana. All rights reserved.

Airport sentinel surveillance and entry quarantine for dengue infections following a fever screening program in Taiwan.

PubMed

Kuan, Mei-Mei; Chang, Feng-Yee

2012-08-06

Dengue has not reached an endemic status in Taiwan; nevertheless, we have implemented a fever screening program at airports for the early detection of febrile passengers with a dengue infection. This study is intended to assess the performance of the airport screening procedures for dengue infection. We analyzed data from the national surveillance system of the Taiwan Centers for Disease Control. We included the imported dengue cases reported by sentinel airports and clinics as well as the domestic cases from 2007-2010. Approximately 44.9% (95%CI: 35.73-54.13%) of the confirmed imported dengue cases with an apparent symptom (febrile) in the viremic stage were detected via the airport fever screening program, with an estimated positive predictive value of 2.36% (95% CI: 0.96- 3.75%) and a negative predictive value > 99.99%. Fluctuations in the number of the symptomatic imported dengue cases identified in the airports (X) were associated with the total number of imported dengue cases (Y) based on a regression analysis of a biweekly surveillance (i.e., n = 104, R(2)(X:Y) = 0.61, P < 0.005). Additionally, the fluctuating patterns in the cumulative numbers of the imported dengue cases (X) with a 1-2 month lead time (t) was in parallel with that of the domestic dengue cases (Y) based on a consecutive 4-year surveillance (i.e., n = 48, R(2)(X(t-1):Y) = 0.22, R(2)(X(t-2):Y) = 0.31, P < 0.001) from 2007-2010. A moderate sensitivity of detecting dengue at the airports examined in this study indicated some limitations of the fever screening program for the prevention of importation. The screening program could assist in the rapid triage for self-quarantine of some symptomatic dengue cases that were in the viremic stage at the borders and contribute to active sentinel surveillance; however, the blocking of viral transmission to susceptible populations (neighbors or family) from all of the viremic travelers, including those with or without symptoms, is critical to prevent dengue epidemics. Therefore, the reinforcement of mosquito bite prevention and household vector control in dengue-endemic or dengue-competent hotspots during an epidemic season is essential and highly recommended.

Estimating shipping emissions in the region of the Sea of Marmara, Turkey.

PubMed

Deniz, Cengiz; Durmuşoğlu, Yalçin

2008-02-01

Ship emissions are significantly increasing globally and have remarkable impact on air quality on sea and land. These emissions contribute serious adverse health and environmental effects. Territorial waters, inland seas and ports are the regions most affected by ship emissions. As an inland sea the Sea of Marmara is an area that has too much ship traffic. Since the region of the Marmara is highly urbanized, emissions from ships affect human health and the overall environment. In this paper exhaust gas emissions from ships in the Sea of Marmara and the Turkish Straits are calculated by utilizing the data acquired in 2003. Main engine types, fuel types, operations types, navigation times and speeds of vessels are taken into consideration in the study. Total emissions from ships in the study area were estimated as 5,451,224 t y(-1) for CO(2), 111,039 t y(-1) for NO(x), 87,168 t y(-1) for SO(2), 20,281 t y(-1) for CO, 5801 t y(-1) for VOC, 4762 t y(-1) for PM. The shipping emissions in the region are equivalent to 11% of NO(x) 0.1% of CO and 0.12% of PM of the corresponding total emissions in Turkey. The shipping emissions in the area are 46% of NO(x), 25% of PM and 1.5% of CO of road traffic emissions in Turkey data between which and correspond to a higher level than aircraft emissions and rail emissions in Turkey.

Targeted prevention of excess weight gain and eating disorders in high-risk adolescent girls: a randomized controlled trial12345

PubMed Central

Shomaker, Lauren B; Wilfley, Denise E; Young, Jami F; Sbrocco, Tracy; Stephens, Mark; Ranzenhofer, Lisa M; Elliott, Camden; Brady, Sheila; Radin, Rachel M; Vannucci, Anna; Bryant, Edny J; Osborn, Robyn; Berger, Sarah S; Olsen, Cara; Kozlosky, Merel; Reynolds, James C; Yanovski, Jack A

2014-01-01

Background: The high prevalence and incidence of obesity and eating disorders in US adolescent girls are serious health problems. Because of the shared risk factors for obesity and eating disorders, a targeted prevention of both conditions is a priority. Objective: We determined whether an adapted interpersonal psychotherapy prevention program is more efficacious for reducing excess weight gain and worsening disordered eating than health education in adolescent girls at high risk of obesity and eating disorders. Design: A parallel-group, randomized controlled trial was conducted between September 2008 and January 2013 in a university-based laboratory and a federal research hospital. The study included 113 adolescent (12–17-y-old) girls deemed at high risk of adult obesity and eating disorders because of a body mass index (BMI) between the 75th and 97th percentiles and reports of episodes of a loss of control over their eating. Girls were randomly assigned to participate in an adapted interpersonal psychotherapy or a health-education group program for 12 weekly 90-min group sessions. Follow-up assessments occurred immediately after group programs and at 6 and 12 mo. Results: Participation in both conditions was associated with decreases in expected BMI gain, age-adjusted BMI metrics, the percentage of fat by using dual-energy X-ray absorptiometry, symptoms of depression and anxiety, and the frequency of loss-of-control eating over 12 mo of follow-up (Ps < 0.001) with no group difference. In follow-up analyses, interpersonal psychotherapy was more efficacious than health education at reducing objective binge eating at the 12-mo follow-up (P < 0.05). Conclusions: The intervention with adolescent girls with loss-of-control eating is associated with lower age-adjusted BMI and percentage of adiposity as well as improved mood symptoms over 1 y. Interpersonal psychotherapy further reduced objective binge eating. Additional research is needed to elucidate the mechanisms by which physical and psychological improvements were observed. This trial was registered at clinicaltrials.gov as NCT00680979. PMID:25240070

Surface radiological investigations at White Wing Scrap Yard, Oak Ridge Reservation, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, J.K.; Rodriguez, R.E.; Uziel, M.S.

1991-09-01

A surface radiological scoping survey of accessible areas at the White Wing Scrap Yard (Waste Area Grouping 11 (WAG 11)) was conducted intermittently from December 1989 through July 1991 by members of the Measurement Applications and Development Group, Health and Safety Research Division, Oak Ridge National Laboratory (ORNL) at the request of Environmental Restoration Program personnel at ORNL. The White Wing Scrap Yard is an estimated 30-acre, predominately wooded area located on the western edge of East Fork Ridge in the McNew Hollow area on the US Department of Energy's Oak Ridge Reservation. The scrap yard was formerly used formore » aboveground storage of contaminated material (e.g., steel tanks, metal, glass, concrete, and miscellaneous industrial trash) from the Oak Ridge K-25 Site, Oak Ridge Y-12 Plant, and ORNL. The purposes of this cursory investigation were (1) to provide an updated contamination status of the site by locating and interpreting the presence, nature, and extent of surface radiological contamination and (2) to provide a basis for the formulation of interim corrective action to limit human exposures to radioactivity and minimize the potential for contaminant dispersion. 13 refs., 17 figs., 5 tabs.« less

Y{sub 2}MoSe{sub 3}O{sub 12} and Y{sub 2}MoTe{sub 3}O{sub 12}: Solid-state synthesis, structure determination, and characterization of two new quaternary mixed metal oxides containing asymmetric coordination environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bang, Seong-eun; Pan, Zhi; Kim, Yeong Hun

Two new quaternary yttrium molybdenum selenium/tellurium oxides, Y{sub 2}MoSe{sub 3}O{sub 12} and Y{sub 2}MoTe{sub 3}O{sub 12} have been prepared by standard solid-state reactions using Y{sub 2}O{sub 3}, MoO{sub 3}, and SeO{sub 2} (or TeO{sub 2}) as reagents. Single-crystal X-ray diffraction was used to determine the crystal structures of the reported materials. Although both of the materials contain second-order Jahn–Teller (SOJT) distortive cations and are stoichiometrically similar, they reveal different structural features: while Y{sub 2}MoSe{sub 3}O{sub 12} shows a three-dimensional framework consisting of YO{sub 8}, MoO{sub 6}, and SeO{sub 3} groups, Y{sub 2}MoTe{sub 3}O{sub 12} exhibits a layered structure composed ofmore » YO{sub 8}, MoO{sub 4}, TeO{sub 3}, and TeO{sub 4} polyhedra. With the Mo{sup 6+} cations in Y{sub 2}MoSe{sub 3}O{sub 12}, a C{sub 3}-type intraoctahedral distortion toward a face is observed, in which the direction of the out-of-center distortion for Mo{sup 6+} is away from the oxide ligand linked to a Se{sup 4+} cation. The Se{sup 4+} and Te{sup 4+} cations in both materials are in asymmetric coordination environment attributed to the lone pairs. Elemental analyses, infrared spectroscopy, thermal analyses, intraoctahedral distortions, and dipole moment calculations for the compounds are also presented. - Graphical abstract: Y{sub 2}MoSe{sub 3}O{sub 12} reveals a three-dimensional framework consisting of YO{sub 8}, MoO{sub 6}, and SeO{sub 3} polyhedra, whereas Y{sub 2}MoTe{sub 3}O{sub 12} exhibits a layered structure composed of YO{sub 8}, MoO{sub 4}, TeO{sub 3}, and TeO{sub 4} groups. - Highlights: • Two new selenite and tellurite (Y{sub 2}MoQ{sub 3}O{sub 12}; Q=Se and Te) are synthesized. • Y{sub 2}MoQ{sub 3}O{sub 12} contain second-order Jahn–Teller distortive cations in asymmetric environments. • The intra-octahedral distortion of the Mo{sup 6+} is influenced by the Se{sup 4+}.« less

Platelets Express Activated P2Y12 Receptor in Patients With Diabetes Mellitus.

PubMed

Hu, Liang; Chang, Lin; Zhang, Yan; Zhai, Lili; Zhang, Shenghui; Qi, Zhiyong; Yan, Hongmei; Yan, Yan; Luo, Xinping; Zhang, Si; Wang, Yiping; Kunapuli, Satya P; Ye, Hongying; Ding, Zhongren

2017-08-29

Platelets from patients with diabetes mellitus are hyperactive. Hyperactivated platelets may contribute to cardiovascular complications and inadequate responses to antiplatelet agents in the setting of diabetes mellitus. However, the underlying mechanism of hyperactivated platelets is not completely understood. We measured P2Y 12 expression on platelets from patients with type 2 diabetes mellitus and on platelets from rats with diabetes mellitus. We also assayed platelet P2Y 12 activation by measuring cAMP and VASP phosphorylation. The antiplatelet and antithrombotic effects of AR-C78511 and cangrelor were compared in rats. Finally, we explored the role of the nuclear factor-κB pathway in regulating P2Y 12 receptor expression in megakaryocytes. Platelet P2Y 12 levels are 4-fold higher in patients with type 2 diabetes mellitus compared with healthy subjects. P2Y 12 expression correlates with ADP-induced platelet aggregation (r=0.89, P <0.01). P2Y 12 in platelets from patients with diabetes mellitus is constitutively activated. Although both AR-C78511, a potent P2Y 12 inverse agonist, and cangrelor have similar antiplatelet efficacy on platelets from healthy subjects, AR-C78511 exhibits more powerful antiplatelet effects on diabetic platelets than cangrelor (aggregation ratio 36±3% versus 49±5%, respectively, P <0.05). Using a FeCl 3 -injury mesenteric arteriole thrombosis model in rats and an arteriovenous shunt thrombosis model in rats, we found that the inverse agonist AR-C78511 has greater antithrombotic effects on GK rats with diabetes mellitus than cangrelor (thrombus weight 4.9±0.3 mg versus 8.3±0.4 mg, respectively, P <0.01). We also found that a pathway involving high glucose-reactive oxygen species-nuclear factor-κB increases platelet P2Y 12 receptor expression in diabetes mellitus. Platelet P2Y 12 receptor expression is significantly increased and the receptor is constitutively activated in patients with type 2 diabetes mellitus, which contributes to platelet hyperactivity and limits antiplatelet drug efficacy in type 2 diabetes mellitus. © 2017 American Heart Association, Inc.

Evaluation of Calendar Year 1997 Groundwater and Surface Water Quality Data For The Upper East Fork Poplar Creek Hydrogeologic Regime At The U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, S.B.

1998-09-01

1 1.0 INTRODUCTION This report presents an evaluation of the groundwater quality monitoring data reported in: Calendar Year 1997 Annual Groundwatw Monitoring Report for the Upper East Fork Poplar Creek Hydrogeologtc Rep-meat the US. Department of Energy Y-12 Plant, Oak Ridge, Tennessee (AJA Technical Services, Inc. 1998), which is hereafter referenced as the Annual Monitoring Report. Section 2.0 presents background information for the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime) that is relevant to data evaluation, including brief descriptions of the geology, the groundwater flow system, the contaminant source areas, and the extent of groundwater contamination inmore » the regime. Section 3.0 provides an overview of the groundwater sampling and analysis activities petiormed during calendar year (CY) 1997, including monitoring well locations, sampling frequency and methods, and laboratory analyses. Evaluation and interpretation of the monitoring da% described in Section 4.0, is generally focused on an overview of data quality assurance/quality control (QA/QC), long-term concentration trends for selected inorganic, organic, and radiological contaminants, and consistency with applicable site-specific conceptual contaminant transport models described in: Report on the Remedial Investigation of the Upper East Fork Poplar Creek Characterization Area at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee (U.S. Department of Energy 1998), which is referenced hereafter as the Remedial Investigation @I) Report. Findings of the data evaluations are summarized :in Section 5.0 and a list of technical reports and regulatory documents cited for more detailed irdormation (Section 6.0) concludes the report. All of the illustrations (maps and trend graphs) and data summary tables referenced in the text are presented in Appendm A and Appendix B, respectively. Appendix C provides a summary of the analytical results that meet applicable data quality objectives (DQOS) of the Y-12 Plant Groundwater Protection Program.« less

Nutritional status of Khasi schoolgirls in Meghalaya.

PubMed

Agrahar-Murugkar, Dipika

2005-04-01

The nutritional status of 222 Khasi girls within age groups 4 to 6 y, 7 to 9 y, and 10 to 12 y was studied. Personal interviews using questionnaires and 24-h dietary recall were used. Weights and heights were recorded, body mass index was calculated, and children were classified as normal or malnourished using Z scores and growth charts from the Centers for Disease Control and Prevention. Based on weights and heights, children were classified as normal or undernourished according to classifications by Gomez, Waterlow, and the National Center for Health Statistics. Heights of girls ages 7 to 9 y and 10 to 12 y and weights of all girls were significantly (P < 0.05) lower than the reference values for height (126.4 and 142.7 m) and weight (19, 26.9, and 31.5 kg), respectively. The lowest Z scores (-1.5 to -1.0) and percentiles (10th) for body mass index were seen in 12-y-old girls. Most girls ages 7 to 9 y had grade I malnutrition. Girls ages 10 to 12 y had the highest incidence of moderate malnutrition. Severe stunting was observed in all groups. Average energy consumption was significantly (P < 0.05) lower than the recommended dietary allowance in all the age groups. Consumption of protein by children ages 7 to 9 y and 10 to 12 y was also significantly lower than the recommended dietary allowance. Consumption of calcium, iron, and carotene in children 10 to 12 y old was significantly (P < 0.05) lower than the recommended dietary allowance. Sociologic community factors are required to facilitate implementation of a nutritional package and availability of key nutrients to ensure growth in children.

P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway.

PubMed

Li, Wei-Hua; Qiu, Ying; Zhang, Hong-Quan; Tian, Xin-Xia; Fang, Wei-Gang

2015-01-01

As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and metastasis in vitro and in vivo via regulating the expressions of some epithelial-mesenchymal transition/invasion-related genes (including IL-8, E-cadherin, Snail and Claudin-1), and the most significant change in expression of IL-8 was observed after P2Y2 receptor activation. However, the signaling pathway downstream of P2Y2 receptor and the role of IL-8 in P2Y2-mediated prostate cancer cell invasion remain unclear. Here, we found that extracellular ATP/UTP induced activation of EGFR and ERK1/2. After knockdown of P2Y2 receptor, the ATP -stimulated phosphorylation of EGFR and ERK1/2 was significantly suppressed. Further experiments showed that inactivation of EGFR and ERK1/2 attenuated ATP-induced invasion and migration, and suppressed ATP-mediated IL-8 production. In addition, knockdown of IL-8 inhibited ATP-mediated invasion and migration of prostate cancer cells. These findings suggest that P2Y2 receptor and EGFR cooperate to upregulate IL-8 production via ERK1/2 pathway, thereby promoting prostate cancer cell invasion and migration. Thus blocking of the P2Y2-EGFR-ERK1/2 pathway may provide effective therapeutic interventions for prostate cancer.

All-digital 1.2-Gbit/s real-time HDTV VTR

NASA Astrophysics Data System (ADS)

Thorpe, Laurence J.; Yoshinaka, T.

1992-08-01

In 1984 the first real-time HDTV video tape recorder was introduced. The HDV-1000 was an analog VTR using one inch metal oxide tape and standard SMPTE open reels. It utilized basic Type-C recording principles although also incorporating a considerably higher FM carrier frequency, twice the deviation, and slightly more preemphasis, - all to achieve a 10 MHz baseband video recording bandwidth capability. Four such component analog recording channels were utilized in parallel to achieve a total recording capability of 40 MHz - made up of 20 MHz for the green video signal (or Luminance Y) and 10 MHz each for the red and blue signals (or R-Y and B-Y components in the case of Y, R-Y, B-Y recording). Almost 150 of these machines supported the early pioneering years of HDTV development - worldwide - over the period 1984 to the late 1980's. The HDTV video signal format to which this VTR was designed was based upon the preliminary 1 125/60/16:9/2: 1 system - having specified system bandwiths of 20 MHz for Luminance Y, and 7.0MHz R-Y, and 5.5 MHz B-Y. The HDV-1000 proved to be a remarkably robust, reliable HD VTR workhorse and it early and firmly established the viability of reliable RD real-time image capture. Nevertheless, it's technical shortcomings were soon exposed by a creative and demanding international program production community. The limitations of two channels of analog audio recording, and about four generations of liD video recording in post-production were inconsistent with the needs of high-end program production. The 45 db signal to noise limitation also imposed a boundary to the quality of the HDTV tape to 35 mm film transfers being made by both Electron Beam and Laser Recording techniques. The HDV-1000 had, however, pushed the state of the art in analog FM recording to the boundary. Head and tape technologies were not expected to advance sufficiently to warrant a new generation in analog recording design. Attention thus turned to digital recording techniques.

PROCEEDINGS OF THE SCIENTIFIC REVIEW MEETING ON THE U.S. ENVIRONMENTAL PROTECTION AGENCY DIESEL EMISSION HEALTH EFFECTS RESEARCH PROGRAM HELD AT THE PENTAGON CITY QUALITY INN, ARLINGTON, VIRGINIA ON DECEMBER 12-13, 1978

EPA Science Inventory

The report is the proceedings of a scientific review meeting of the ongoing diesel emission health effects research program. The proceedings include formal presentations by Agency investigators and discussions of these presentations by those in attendance. Written comments on the...

Changes in Social Capital and Networks: A Study of Community-Based Environmental Management through a School-Centered Research Program

ERIC Educational Resources Information Center

Thornton, Teresa; Leahy, Jessica

2012-01-01

Social network analysis (SNA) is a social science research tool that has not been applied to educational programs. This analysis is critical to documenting the changes in social capital and networks that result from community based K-12 educational collaborations. We review SNA and show an application of this technique in a school-centered,…

Detection of Clonorchis sinensis circulating antigen in sera from Chinese patients by immunomagnetic bead ELISA based on IgY.

PubMed

Nie, Ge; Wang, Ting; Lu, Shengjun; Liu, Wenqi; Li, Yonglong; Lei, Jiahui

2014-01-01

Clonorchiasis, caused by Clonorchis sinensis, is widely distributed in Southeast Asia including China. Clonorchiasis is included in control programs of neglected tropical diseases by World Health Organization (WHO) because it is one of the major health problems in most endemic areas. Diagnosis of clonorchiasis plays a key role in the control programs. However, so far, there is no satisfactory method for clonorchiasis because of low sensitivity, poor practicality and high false positivity of available diagnostic tools. We developed an immunomagnetic bead enzyme-linked immunosorbent assay (ELISA) based on IgY (egg yolk immunoglobulin) against cysteine proteinase of C. sinensis for detection of circulating antigen in serum samples of patients infected with C. sinensis. The polyclonal IgY, coated with magnetic beads, was used as a capture antibody and a monoclonal IgG labeled with horseradish peroxidase as a detection antibody in the IgY-based immunomagnetic bead ELISA system (IgY-IMB-ELISA). The results showed that the sensitivity of IgY-IMB-ELISA was 93.3% (14 of 15) in cases of heavy infection (5000 to 9999 eggs per gram feces, i.e, EPG 5000-9999), 86.7% (13 of 15) in cases of moderate infection (EPG 1000-4999) and 75.0% (9 of 12) in cases of light infection (EPG <1000) of clonorchiasis. Together 36 of total 42 (85.7%) serum samples of human clonorchiasis gave a positive reaction. There was a significant correlation between ELISA optical density and egg counts (EPG) with a correlation coefficient of 0.83 in total 42 patients. There were no positive results in patients with trichinosis (n = 10) or cysticercosis (n = 10). Cross-reactivity was 6.7% (2 of 30) with schistosomiasis japonica and 10.0% (3 of 30) with paragonimiasis, respectively. No positive reaction was found in 20 healthy persons. Our findings suggest that IgY-IMB-ELISA appears to be a sensitive and specific assay for detection of circulating antigen in human clonorchiasis.

Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization*

PubMed Central

Nisar, Shaista P.; Cunningham, Margaret; Saxena, Kunal; Pope, Robert J.; Kelly, Eamonn; Mundell, Stuart J.

2012-01-01

We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y12 receptor (P2Y12R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor (GPCR) internalization. NHERF1 interacts with the C-tail of the P2Y12R and unlike many other GPCRs, NHERF1 interaction is required for effective P2Y12R internalization. In vitro and prior to agonist stimulation P2Y12R/NHERF1 interaction requires the intact PDZ binding motif of this receptor. Interestingly on receptor stimulation NHERF1 no longer interacts directly with the receptor but instead binds to the receptor via the endocytic scaffolding protein arrestin. These findings suggest a novel model by which arrestin can serve as an adaptor to promote NHERF1 interaction with a GPCR to facilitate effective NHERF1-dependent receptor internalization. PMID:22610101

Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization.

PubMed

Nisar, Shaista P; Cunningham, Margaret; Saxena, Kunal; Pope, Robert J; Kelly, Eamonn; Mundell, Stuart J

2012-07-13

We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor (GPCR) internalization. NHERF1 interacts with the C-tail of the P2Y(12)R and unlike many other GPCRs, NHERF1 interaction is required for effective P2Y(12)R internalization. In vitro and prior to agonist stimulation P2Y(12)R/NHERF1 interaction requires the intact PDZ binding motif of this receptor. Interestingly on receptor stimulation NHERF1 no longer interacts directly with the receptor but instead binds to the receptor via the endocytic scaffolding protein arrestin. These findings suggest a novel model by which arrestin can serve as an adaptor to promote NHERF1 interaction with a GPCR to facilitate effective NHERF1-dependent receptor internalization.

Reduced-Order Observer Model for Antiaircraft Artillery (AAA) Tracker Response

DTIC Science & Technology

1979-08-01

a22 -ka1 2) z + (a22 - ka1 2) ky + (a21 - kall ) y + (b2 - kb) uc (10) Next, the actual output of this model is expressed as the sum of the output u...a22x2 + b2u + f2eT = (a2 2 - kal2) z + (a2 2 - ka12) ky + (a21 - kall ) y + (b2 - kb l ) uc u=u +vC [Ti Y2] [y] By introducing new variables: X3 = x2...x3 [(a22- ka2)k + (a2- kall ) - (b2- kb) (YI + kY2) Y + [a22 - ka12 - (b2 - kbl) Y2] X3 + (b2 -kbl) y2 e + (2 - kbI) v + (f2 - kfl) 0 T e = (a22- ka12

Vol. 58 No. 90 Wednesday, May 12, 1993 p 28094 (Proposed Rule)

EPA Pesticide Factsheets

This action proposes the U.S. Environmental Protection Agency's (EPA) program for evaluating and regulating substitutes for the ozone-depleting chemicals being phased out under the stratospheric ozone protection provisions of the Clean Air Act (CAA).

40 CFR 304.12 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS General... amended by the Superfund Amendments and Reauthorization Act of 1986, Pub. L. 99-499, 100 Stat. 1613 (1986...

40 CFR 304.12 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS General... amended by the Superfund Amendments and Reauthorization Act of 1986, Pub. L. 99-499, 100 Stat. 1613 (1986...

40 CFR 304.12 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS General... amended by the Superfund Amendments and Reauthorization Act of 1986, Pub. L. 99-499, 100 Stat. 1613 (1986...

40 CFR 304.12 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS General... amended by the Superfund Amendments and Reauthorization Act of 1986, Pub. L. 99-499, 100 Stat. 1613 (1986...

7 CFR 1410.62 - Miscellaneous.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION RESERVE PROGRAM § 1410.62 Miscellaneous. (a... to the requirements of part 12 of this title concerning highly erodible land and wetland conservation... economic and environmental information, not adversely affect local agricultural markets, and be conducted...

Accessing Programs for Infants, Toddlers, and Preschoolers with Disabilities: A Parent's Guide = Programas para Infantes y Ninos Pre-escolares con Discapacidades: Guia para Padres de Familia. Update.

ERIC Educational Resources Information Center

Kupper, Lisa, Ed.

This parent's guide (presented in both English and Spanish) is intended to help families access services for young children with special needs. It is presented in the form of questions and answers arranged in three parts. Part I presents 12 questions and answers about early intervention services for infants and toddlers (ages birth through 2…

Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.

PubMed

Aungraheeta, Riyaad; Conibear, Alexandra; Butler, Mark; Kelly, Eamonn; Nylander, Sven; Mumford, Andrew; Mundell, Stuart J

2016-12-08

Ticagrelor is a potent antagonist of the P2Y 12 receptor (P2Y 12 R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater inhibition of adenosine 5'-diphosphate (ADP)-induced Ca 2+ release in washed platelets vs other P2Y 12 R antagonists. This additional effect of ticagrelor beyond P2Y 12 R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of G s -coupled adenosine A 2A receptors. This contributed to an increase in basal cyclic adenosine monophosphate (cAMP) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P). In addition, ticagrelor increased platelet cAMP and VASP-P in the absence of ADP in an adenosine receptor-independent manner. We hypothesized that this increase originated from a direct effect on basal agonist-independent P2Y 12 R signaling, and this was validated in 1321N1 cells stably transfected with human P2Y 12 R. In these cells, ticagrelor blocked the constitutive agonist-independent activity of the P2Y 12 R, limiting basal G i -coupled signaling and thereby increasing cAMP levels. These data suggest that ticagrelor has the pharmacological profile of an inverse agonist. Based on our results showing insurmountable inhibition of ADP-induced Ca 2+ release and forskolin-induced cAMP, the mode of antagonism of ticagrelor also appears noncompetitive, at least functionally. In summary, our studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y 12 R that contribute to its effective inhibition of platelet activation. © 2016 by The American Society of Hematology.

Methods to improve routine bioassay monitoring for freshly separated, poorly transported plutonium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bihl, D.E.; Lynch, T.P.; Carbaugh, E.H.

1988-09-01

Several human cases involving inhalation of plutonium oxide at Hanford have shown clearance half-times from the lung that are much longer than the 500-day half-time recommended for class Y plutonium in Publication 30 of the International Commission on Radiological Protection(ICRP). The more tenaciously retained material is referred to as super class Y plutonium. The ability to detect super class Y plutonium by current routine bioassay measurements is shown to be poor. Pacific Northwest Laboratory staff involved in the Hanford Internal Dosimetry Program investigated four methods to se if improvements in routine monitoring of workers for fresh super class Y plutoniummore » are feasible. The methods were lung counting, urine sampling, fecal sampling, and use of diethylenetriaminepentaacetate (DTPA) to enhance urinary excretion. Use of DTPA was determined to be not feasible. Routine fecal sampling was found to be feasible but not recommended. Recommendations were made to improve the detection level for routine annual urinalysis and routine annual lung counting. 12 refs., 9 figs., 7 tabs.« less

MIZEX. A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. III. Modeling the Marginal Ice Zone,

DTIC Science & Technology

1984-04-01

Ii TS C]r.I2 TAB 0] Unzanro’ unoed 0 justi fica ~r: 0 April 1984 vs - ASValabilitY Codes lvyall and/or U.S. Army Cold Regions Research and Engineering...coupled model. Fig. 1. Annual average simulated velocity fields. 3 192 Aloka 190 / 902 190+ WOO S’,. o Ice OnlY Mod" D"’, 55*w F~tth Yea’ Ice Ocean Model...A more precise delinga- inflow boundary conditions. 12 4- a. [ o ll ii traspert 00 0 0- 0e a I " i i , - - I I 1161 63 15 67 69 Ti 73 75 77 1980 *= 4h

Synthesis and anticandidal activity of some imidazopyridine derivatives.

PubMed

Kaplancikli, Zafer Asim; Turan-Zitouni, Gülhan; Ozdemir, Ahmet; Revial, Gilbert

2008-12-01

New hydrazide derivatives of imidazo[1,2-a]pyridine have been synthesized and evaluated for anticandidal activity. The reaction of imidazo[1,2-a]pyridine-2-carboxylic acid hydrazides with various benzaldehydes gave N-(benzylidene)imidazo[ 1,2-a]pyridine-2-carboxylic acid hydrazide derivatives. Their anticandidal activities against Candida albicans and Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir, Turkey), Candida albicans (ATCC 90028), Candida utilis (NRLL Y-900), Candida tropicalis (NRLL Y-12968), Candida krusei (NRLL Y-7179), Candida zeylanoides (NRLL Y-1774), and Candida parapsilosis (NRLL Y-12696) were investigated.

Reference levels of background radioactivity for beach sands and soils in İnebolu/Kastamonu-Turkey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurnaz, Aslı, E-mail: akurnaz@kastamonu.edu.tr; Türkdoğan, Savaş, E-mail: savas-turk-dogan@hotmail.com; Hançerlioğulları, Aybaba, E-mail: aybaba@kastamonu.edu.tr

This paper presents the measurement results of environmental radioactivity levels for İnebolu district (tourist area), Kastamonu-Turkey. The radioactivity concentrations of {sup 238}U, {sup 232}Th, {sup 40}K and the fission product {sup 137}Cs in soil samples collected from 13 region surroundings of study area and in 12 beach sand samples collected from along the coast of İnebolu were determined. To evaluate the radiological hazard of the natural radioactivity, based on the measured concentrations of these radionuclides, the mean absorbed gamma dose and the annual effective dose were evaluated separately, and found to be 112.90 nGy h-1 and 138.46 µSv y-1 for soilmore » samples and 75.19 nGy h-1 and 92.22 µSv y-1 for beach sand samples, respectively. The results show that İnebolu does not have high background.« less

Reference levels of background radioactivity for beach sands and soils in İnebolu/Kastamonu-Turkey

NASA Astrophysics Data System (ADS)

Kurnaz, Aslı; Türkdoǧan, Savaş; Hançerlioǧulları, Aybaba; ćetiner, M. Atıf

2016-03-01

This paper presents the measurement results of environmental radioactivity levels for İnebolu district (tourist area), Kastamonu-Turkey. The radioactivity concentrations of 238U, 232Th, 40K and the fission product 137Cs in soil samples collected from 13 region surroundings of study area and in 12 beach sand samples collected from along the coast of İnebolu were determined. To evaluate the radiological hazard of the natural radioactivity, based on the measured concentrations of these radionuclides, the mean absorbed gamma dose and the annual effective dose were evaluated separately, and found to be 112.90 nGy h-1 and 138.46 µSv y-1 for soil samples and 75.19 nGy h-1 and 92.22 µSv y-1 for beach sand samples, respectively. The results show that İnebolu does not have high background.

The Application of System Dynamics to the Integration of National Laboratory Research and K-12 Education

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mills, James Ignatius; Zounar Harbour, Elda D

2001-08-01

The Idaho National Engineering and Environmental Laboratory (INEEL) is dedicated to finding solutions to problems related to the environment, energy, economic competitiveness, and national security. In an effort to attract and retain the expertise needed to accomplish these challenges, the INEEL is developing a program of broad educational opportunities that makes continuing education readily available to all laboratory employees, beginning in the K–12 environment and progressing through post-graduate education and beyond. One of the most innovative educational approaches being implemented at the laboratory is the application of STELLA© dynamic learning environments, which facilitate captivating K–12 introductions to the complex energymore » and environmental challenges faced by global societies. These simulations are integrated into lesson plans developed by teachers in collaboration with INEEL scientists and engineers. This approach results in an enjoyable and involved learning experience, and an especially positive introduction to the application of science to emerging problems of great social and environmental consequence.« less

Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma.

PubMed

Bunyavanich, S; Boyce, J A; Raby, B A; Weiss, S T

2012-02-01

Distinct receptors likely exist for leukotriene (LT)E(4), a potent mediator of airway inflammation. Purinergic receptor P2Y12 is needed for LTE(4)-induced airways inflammation, and P2Y12 antagonism attenuates house dust mite-induced pulmonary eosinophilia in mice. Although experimental data support a role for P2Y12 in airway inflammation, its role in human asthma has never been studied. To test for association between variants in the P2Y12 gene (P2RY12) and lung function in human subjects with asthma, and to examine for gene-by-environment interaction with house dust mite exposure. Nineteen single nucleotide polymorphisms (SNPs) in P2RY12 were genotyped in 422 children with asthma and their parents (n = 1266). Using family based methods, we tested for associations between these SNPs and five lung function measures. We performed haplotype association analyses and tested for gene-by-environment interactions using house dust mite exposure. We used the false discovery rate to account for multiple comparisons. Five SNPs in P2RY12 were associated with multiple lung function measures (P-values 0.006–0.025). Haplotypes in P2RY12 were also associated with lung function (P-values 0.0055–0.046). House dust mite exposure modulated associations between P2RY12 and lung function, with minor allele homozygotes exposed to house dust mite demonstrating worse lung function than those unexposed (significant interaction P-values 0.0028–0.040). The P2RY12 variants were associated with lung function in a large family-based asthma cohort. House dust mite exposure caused significant gene-by-environment effects. Our findings add the first human evidence to experimental data supporting a role for P2Y12 in lung function. P2Y12 could represent a novel target for asthma treatment.

Environmental Assessment for the Construction/Operation of an Air National Guard - U.S. Marine Corps Reserve Installation at Stewart International Airport, Newburgh, New York

DTIC Science & Technology

1984-03-01

Transient lodgings Y N(1) N(1) N(1) N N PUBLIC USE Schools , hospitals and nursing Y 25 30 N N N homes Churches, auditoriums, and Y 25 30 N N N concert...fishing, resource Y Y Y Y Y Y production & extraction RECREATIONAL Outdoor sports arenas and Y Y(5) Y(5) N N N spectator sports Outdoor music shells...ATCT personnel, and other agencies as necessary for possible revisions. Attachments (2) -3- , School Denser ____p__ a END Populated • Visual Areas

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study.

PubMed

Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi; Yokoyama, Yoshie; Honda, Chika; Hjelmborg, Jacob vB; Möller, Sören; Ooki, Syuichi; Aaltonen, Sari; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Busjahn, Andreas; Kandler, Christian; Saudino, Kimberly J; Jang, Kerry L; Cozen, Wendy; Hwang, Amie E; Mack, Thomas M; Gao, Wenjing; Yu, Canqing; Li, Liming; Corley, Robin P; Huibregtse, Brooke M; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth Jf; Heikkilä, Kauko; Wardle, Jane; Llewellyn, Clare H; Fisher, Abigail; McAdams, Tom A; Eley, Thalia C; Gregory, Alice M; He, Mingguang; Ding, Xiaohu; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D; Tarnoki, David L; Stazi, Maria A; Fagnani, Corrado; D'Ippolito, Cristina; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Burt, S Alexandra; Klump, Kelly L; Silberg, Judy L; Eaves, Lindon J; Maes, Hermine H; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A; Bartels, Meike; van Beijsterveldt, Toos Cem; Craig, Jeffrey M; Saffery, Richard; Freitas, Duarte L; Maia, José Antonio; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Martin, Nicholas G; Medland, Sarah E; Montgomery, Grant W; Chong, Youngsook; Swan, Gary E; Krasnow, Ruth; Magnusson, Patrik Ke; Pedersen, Nancy L; Tynelius, Per; Lichtenstein, Paul; Haworth, Claire Ma; Plomin, Robert; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Harden, K Paige; Tucker-Drob, Elliot M; Öncel, Sevgi Y; Aliev, Fazil; Spector, Timothy; Mangino, Massimo; Lachance, Genevieve; Baker, Laura A; Tuvblad, Catherine; Duncan, Glen E; Buchwald, Dedra; Willemsen, Gonneke; Rasmussen, Finn; Goldberg, Jack H; Sørensen, Thorkild Ia; Boomsma, Dorret I; Kaprio, Jaakko

2016-08-01

Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity. © 2016 American Society for Nutrition.

Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells.

PubMed

Yamasaki, Masao; Iwase, Masahiro; Kawano, Kazuo; Sakakibara, Yoichi; Suiko, Masahito; Nishiyama, Kazuo

2012-05-01

Here, we focused on the effects of racemic α-lipoic acid on proliferation and adhesion properties of 3Y1 rat fibroblasts and the v-H-ras-transformed derivative, HR-3Y1-2 cells. Racemic α-lipoic acid inhibited proliferation of HR-3Y1-2 but not 3Y1 cells at 0.3 and 1.0 mM. R-(+)-α-lipoic acid also inhibited proliferation of HR-3Y1-2 cells equivalent to that of racemic α-lipoic acid. In addition, racemic α-lipoic acid decreased intracellular reactive oxygen species levels in HR-3Y1 cells but not 3Y1 cells. Next, we evaluated the effects of racemic α-lipoic acid on cell adhesion to fibronectin. The results indicated that racemic α-lipoic acid decreased adhesive ability of HR-3Y1-2 cells to fibronectin-coated plates. As blocking antibody experiment revealed that β1-integrin plays a key role in cell adhesion in this experimental system, the effects of racemic α-lipoic acid on the expression of β1-integrin were examined. The results indicated that racemic α-lipoic acid selectively downregulated the expression of cell surface β1-integrin expression in HR-3Y1-2 cells. Intriguingly, exogenous hydrogen peroxide upregulated cell surface β1-integrin expression in 3Y1 cells. Taken together, these data suggest that reduction of intracellular reactive oxygen species levels by α-lipoic acid could be an effective means of ameliorating abnormal growth and adhesive properties in v-H-ras transformed cells.

Estimates and determinants of HPV non-vaccination and vaccine refusal in girls 12 to 14 y of age in Canada: Results from the Childhood National Immunization Coverage Survey, 2013

PubMed Central

Gilbert, Nicolas L.; Gilmour, Heather; Dubé, Ève; Wilson, Sarah E.; Laroche, Julie

2016-01-01

ABSTRACT Since the introduction of HPV vaccination programs in Canada in 2007, coverage has been below public health goals in many provinces and territories. This analysis investigated the determinants of HPV non-vaccination and vaccine refusal. Data from the Childhood National Immunization Coverage Survey (CNICS) 2013 were used to estimate the prevalence of HPV non-vaccination and parental vaccine refusal in girls aged 12–14 years, for Canada and the provinces and territories. Multivariate logistic regression was used to examine factors associated with non-vaccination and vaccine refusal, after adjusting for potential confounders. An estimated 27.7% of 12–14 y old girls had not been vaccinated against HPV, and 14.4% of parents reported refusing the vaccine. The magnitude of non-vaccination and vaccine refusal varied by province or territory and also by responding parent's country of birth. In addition, higher education was associated with a higher risk of refusal of the HPV vaccine. Rates of HPV non-vaccination and of refusal of the HPV vaccine differ and are influenced by different variables. These findings warrant further investigation. PMID:26942572

Development of improved high temperature coatings for IN-792 + HF

NASA Technical Reports Server (NTRS)

Profant, D. D.; Naik, S. K.

1981-01-01

The development for t-55 l712 engine of high temperature for integral turbine nozzles with improved thermal fatigue resistance without sacrificing oxidation/corrosion protection is discussed. The program evaluated to coating systems which comprised one baseline plasma spray coating (12% Al-NiCoCrALY), three aluminide coatings including the baseline aluminide (701), two CoNiCrAly (6% Al) + aluminide systems and four NiCoCrY + aluminide coating were evaluated. The two-step coating processes were investigated since it offered the advantage of tailoring the composition as well as properly coating surfaces of an integral or segmented nozzle. Cyclic burner rig thermal fatigue and oxidation/corrosion tests were used to evaluate the candidate coating systems. The plasma sprayed 12% Al-NiCoCrAlY was rated the best coating in thermal fatigue resistance and outperformed all coatings by a factor between 1.4 to 2.5 in cycles to crack initiation. However, this coatings is not applicable to integral or segmented nozzles due to the line of sight limitation of the plasma spray process. The 6% Al-CoNiCrAlY + Mod. 701 aluminide (32 w/o Al) was rated the best coating in oxidation/corrosion resistance and was rated the second best in thermal fatigue resistance.

P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2',3'-dideoxycytidine.

PubMed

Yi, Zhihua; Xie, Lihui; Zhou, Congfa; Yuan, Huilong; Ouyang, Shuai; Fang, Zhi; Zhao, Shanhong; Jia, Tianyu; Zou, Lifang; Wang, Shouyu; Xue, Yun; Wu, Bing; Gao, Yun; Li, Guilin; Liu, Shuangmei; Xu, Hong; Xu, Changshui; Zhang, Chunping; Liang, Shangdong

2018-03-01

The direct neurotoxicity of HIV and neurotoxicity of combination antiretroviral therapy medications both contribute to the development of neuropathic pain. Activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) plays a crucial role in mechanical and thermal hyperalgesia. The P2Y 12 receptor expressed in SGCs of the DRG is involved in pain transmission. In this study, we explored the role of the P2Y 12 receptor in neuropathic pain induced by HIV envelope glycoprotein 120 (gp120) combined with ddC (2',3'-dideoxycytidine). A rat model of gp120+ddC-induced neuropathic pain was used. Peripheral nerve exposure to HIV-gp120+ddC increased mechanical and thermal hyperalgesia in gp120+ddC-treated model rats. The gp120+ddC treatment increased expression of P2Y 12 receptor mRNA and protein in DRG SGCs. In primary cultured DRG SGCs treated with gp120+ddC, the levels of [Ca 2+ ] i activated by the P2Y 12 receptor agonist 2-(Methylthio) adenosine 5'-diphosphate trisodium salt (2-MeSADP) were significantly increased. P2Y 12 receptor shRNA treatment inhibited 2-MeSADP-induced [Ca 2+ ] i in primary cultured DRG SGCs treated with gp120+ddC. Intrathecal treatment with a shRNA against P2Y 12 receptor in DRG SGCs reduced the release of pro-inflammatory cytokines, decreased phosphorylation of p38 MAPK in the DRG of gp120+ddC-treated rats. Thus, downregulating the P2Y 12 receptor relieved mechanical and thermal hyperalgesia in gp120+ddC-treated rats.

Incidence and Clinical Features of Early Stent Thrombosis in the Era of New P2y12 Inhibitors (PLATIS-2)

PubMed Central

Asher, Elad; Abu-Much, Arsalan; Goldenberg, Ilan; Segev, Amit; Sabbag, Avi; Mazin, Israel; Shlezinger, Meital; Atar, Shaul; Zahger, Doron; Polak, Arthur; Beigel, Roy; Matetzky, Shlomi

2016-01-01

Early stent thrombosis (EST) (≤ 30 days after stent implantation) is a relatively rare but deleterious complication of percutaneous coronary intervention (PCI). Administration of newer P2Y12 inhibitors (prasugrel and ticagrelor) combined with aspirin has been shown to reduce the incidence of sub-acute and late stent thrombosis, compared with clopidogrel. We investigated the “real life” incidence of EST in patients from a large acute coronary syndrome (ACS) national registry, where newer P2Y12 inhibitors are widely used. Patients were derived from the ACS Israeli Survey (ACSIS), conducted during 2006, 2008, 2010 and 2013. Major adverse cardiac events (MACE) at 30days were defined as all-cause death, recurrent ACS, EST and stroke.Of the 4717 ACS patients who underwent PCI and stenting, 83% received clopidogrel and 17% newer P2Y12 inhibitors. The rate of EST was similar in both groups (1.7% in the newer P2Y12 inhibitor group vs. 1.4% in the clopidogrel-treated patients, p = 0.42). Results were consistent after multivariate analysis (adjusted HR = 1.06 [p = 0.89]). MACE occurred in 6.4% in the newer P2Y12 inhibitor group compared with 9.2% in the clopidogrel group (P<0.01). However, multivariate logistic regression modeling showed that treatment with newer P2Y12 inhibitors was not significantly associated with the secondary endpoint of MACE when compared with clopidogrel therapy [OR = 1.26 95%CI (0.93–1.73), P = 0.136]. The incidence of "real life" EST at 1month is relatively low, and appears to be similar in patients who receive newer P2Y12 inhibitors as well as in those who receive clopidogrel. PMID:27310147

Incidence and Clinical Features of Early Stent Thrombosis in the Era of New P2y12 Inhibitors (PLATIS-2).

PubMed

Asher, Elad; Abu-Much, Arsalan; Goldenberg, Ilan; Segev, Amit; Sabbag, Avi; Mazin, Israel; Shlezinger, Meital; Atar, Shaul; Zahger, Doron; Polak, Arthur; Beigel, Roy; Matetzky, Shlomi

2016-01-01

Early stent thrombosis (EST) (≤ 30 days after stent implantation) is a relatively rare but deleterious complication of percutaneous coronary intervention (PCI). Administration of newer P2Y12 inhibitors (prasugrel and ticagrelor) combined with aspirin has been shown to reduce the incidence of sub-acute and late stent thrombosis, compared with clopidogrel. We investigated the "real life" incidence of EST in patients from a large acute coronary syndrome (ACS) national registry, where newer P2Y12 inhibitors are widely used. Patients were derived from the ACS Israeli Survey (ACSIS), conducted during 2006, 2008, 2010 and 2013. Major adverse cardiac events (MACE) at 30days were defined as all-cause death, recurrent ACS, EST and stroke.Of the 4717 ACS patients who underwent PCI and stenting, 83% received clopidogrel and 17% newer P2Y12 inhibitors. The rate of EST was similar in both groups (1.7% in the newer P2Y12 inhibitor group vs. 1.4% in the clopidogrel-treated patients, p = 0.42). Results were consistent after multivariate analysis (adjusted HR = 1.06 [p = 0.89]). MACE occurred in 6.4% in the newer P2Y12 inhibitor group compared with 9.2% in the clopidogrel group (P<0.01). However, multivariate logistic regression modeling showed that treatment with newer P2Y12 inhibitors was not significantly associated with the secondary endpoint of MACE when compared with clopidogrel therapy [OR = 1.26 95%CI (0.93-1.73), P = 0.136]. The incidence of "real life" EST at 1month is relatively low, and appears to be similar in patients who receive newer P2Y12 inhibitors as well as in those who receive clopidogrel.

Y-chromosome specific alleles and haplotypes in European and Asian populations: linkage disequilibrium and geographic diversity.

PubMed

Mitchell, R J; Earl, L; Fricke, B

1997-10-01

Variation on the Y chromosome may permit our understanding the evolution of the human paternal lineage and male gene flow. This study reports upon the distribution and non random association of alleles at four Y-chromosome specific loci in four populations, three Caucasoid (Italian, Greek and Slav) and one Asian. The markers include insertion/deletion (p12f), point mutation (92R7 and pY alpha I), and repeat sequence (p21A1) polymorphisms. Our data confirm that the p12f/TaqI 8 kb allele is a Caucasoid marker and that Asians are monomorphic at three of the loci (p12f, 92R7, and pY alpha I). The alleles at 92R7 and pY alpha I were found to be in complete disequilibrium in Europeans. Y-haplotype diversity was highly significant between Asians and all three European groups (P < 0.001), but the Greeks and Italians were also significantly different with respect to some alleles and haplotypes (P < 0.02). We find strong evidence that the p12f/TaqI 8 kb allele may have arisen only once, as a deletion event, and, additionally, that the present-day frequency distribution of Y chromosomes carrying the p12f/8 kb allele suggests that it may have been spread by colonising sea-faring peoples from the Near East, possibly the Phoenicians, rather than by expansion of Neolithic farmers into continental Europe. The p12f deletion is the key marker of a unique Y chromosome, found only in Caucasians to date, labelled 'Mediterranean' and this further increases the level of Y-chromosome diversity seen among Caucasoids when compared to the other major population groups.

One Approach to a Marine-Literate Society.

ERIC Educational Resources Information Center

Hawkins, Michael L.; Keach, Everett T., Jr.

1982-01-01

Identifies environmental and economic concerns related to Georgia's coastal areas, describes the content and methodology sections of a K-12 social science and science program about coastal Georgia, and provides a sample activity on population in the coastal areas for the middle school. (DC)

7 CFR 1794.31 - Classification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 12 2013-01-01 2013-01-01 false Classification. 1794.31 Section 1794.31 Agriculture... Classification. (a) Electric and telecommunications programs. RUS will normally determine the proper environmental classification of projects based on its evaluation of the project description set forth in the...

7 CFR 1794.31 - Classification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 12 2012-01-01 2012-01-01 false Classification. 1794.31 Section 1794.31 Agriculture... Classification. (a) Electric and telecommunications programs. RUS will normally determine the proper environmental classification of projects based on its evaluation of the project description set forth in the...

7 CFR 1794.31 - Classification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 12 2014-01-01 2013-01-01 true Classification. 1794.31 Section 1794.31 Agriculture... Classification. (a) Electric and telecommunications programs. RUS will normally determine the proper environmental classification of projects based on its evaluation of the project description set forth in the...

43 CFR 26.7 - Application format and instructions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., if residential project (types of facilities, age, condition, tents, cabins, dormitories, food service). (11) Project staff (number and position titles). (12) Work-learning program. (Describe major projects... environmental learning will be integrated into projects.) (13) Complete calculation for daily rate of enrollee...

Provisional Peer-Reviewed Toxicity Values for 1,2-Dichloropropane

EPA Science Inventory

Provisional Peer-Reviewed Toxicity Values (PPRTVs) are developed by the EPA Office of Research and Development’s National Center for Environmental Assessment, Superfund Health Risk Technical Support Center for OSRTI. Other EPA programs or external parties who may choose of their ...

40 CFR 35.230 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL... Agreements to States (as defined in section 2 of Federal Insecticide, Fungicide, and Rodenticide Act) under... program regulations are at 40 CFR parts 150 through 189 and 19 CFR part 12. ...

40 CFR 35.230 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL... Agreements to States (as defined in section 2 of Federal Insecticide, Fungicide, and Rodenticide Act) under... program regulations are at 40 CFR parts 150 through 189 and 19 CFR part 12. ...

40 CFR 63.1501 - Dates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Dates. 63.1501 Section 63.1501 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Hazardous Air Pollutants for Secondary Aluminum Production General § 63.1501 Dates. (a) The owner or...

7 CFR 1794.31 - Classification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Classification. 1794.31 Section 1794.31 Agriculture... Classification. (a) Electric and telecommunications programs. RUS will normally determine the proper environmental classification of projects based on its evaluation of the project description set forth in the...

7 CFR 1794.31 - Classification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Classification. 1794.31 Section 1794.31 Agriculture... Classification. (a) Electric and telecommunications programs. RUS will normally determine the proper environmental classification of projects based on its evaluation of the project description set forth in the...

THIRD PARTY TECHNOLOGY PERFORMANCE VERIFICATION DATA FROM A STAKEHOLD-DRIVEN TECHNOLOGY TESTING PROGRAM

EPA Science Inventory

The Greenhouse Gas (GHG) Technology Verification Center is one of 12 independently operated verification centers established by the U.S. Environmental Protection Agency. The Center provides third-party performance data to stakeholders interested in environmetnal technologies tha...

Establishment of Lipolexis oregmae (Hymenoptera: Aphidiidae) in a classical biological control program directed against the brown citrus aphid (Homoptera: Aphididae) in Florida

DOE Office of Scientific and Technical Information (OSTI.GOV)

Persad, A.B.; Hoy, M.A.; Ru Nguyen

The parasitoid Lipolexis oregmae Gahan (introduced as L. scutellaris Mackauer) was imported from Guam, evaluated in quarantine, mass reared, and released into citrus groves in Florida in a classical biological control program directed against the brown citrus aphid, Toxoptera citricida Kirkaldy. Releases of 20,200, 12,100, and 1,260 adults of L. oregmae were made throughout Florida during 2000, 2001, and 2002, respectively. To determine if L. oregmae had successfully established, surveys were conducted throughout the state beginning in the summer of 2001 and continuing through the summer of 2003. Parasitism during 2001 and 2002 was evaluated by holding brown citrus aphidsmore » in the laboratory until parasitoid adults emerged. Lipolexis oregmae was found in 10 sites in 7 counties and 4 sites in 3 counties with parasitism rates ranging from 0.7 to 3.3% in 2001 and 2002, respectively. Laboratory tests indicated that high rates of mortality occurred if field-collected parasitized aphids were held in plastic bags, so a molecular assay was used that allowed immature L. oregmae to be detected within aphid hosts immediately after collection. The molecular assay was used in 2003 with the brown citrus aphids and with other aphid species collected from citrus, weeds, and vegetables near former release sites; immatures of L. oregmae were detected in black citrus aphids, cowpea aphids, spirea aphids, and melon aphids, as well as in the brown citrus aphid, in 4 of 8 counties sampled, with parasitism ranging from 2.0 to 12.9%, indicating that L. oregmae is established and widely distributed. Samples taken in Polk County during Oct 2005 indicated that L. oregmae has persisted. The ability of L. oregmae to parasitize other aphid species on citrus, and aphids on other host plants, enhances the ability of L. oregmae to persist when brown citrus aphid populations are low. (author) [Spanish] El parasitoide Lipolexis oregmae Gahan (introducido como L. scutellaris Mackauer) fue importado de Guam, evaluado en cuarentena, criado en masa y liberado en huertos de citricos en un programa de control biologico clasico dirigido contra el afido pardo de citricos, Toxoptera citricida Kirkaldy. Se hicieron liberaciones de 20,200, 12,100, y 1,260 adultos de L. oregmae a traves de la Florida durante los anos de 2000, 2001, y 2002, respectivamente. Para determinar si L. oregmae ha logrado en establecer, se realizaron sondeos a traves del estado empezando en el verano del 2001 y continuando hasta el final del verano del 2003. El parasitismo durante 2001 y 2002 fue evaluado con el mantenimiento de individuos del afido pardo de los citricos en el laboratorio hasta que los adultos emergieron. Lipolexis oregmae fue encontrado en 10 sitios en 7 condados y con tasas de parasitismo en 4 sitios en 3 condados entre 0.7 a 3.3% en el 2001 y 2002, respectivamente. Las pruebas del laboratorio indicaron que las tasas altas de mortalidad fueron posibles si los afidos con parasitos recolectados en el campo fueron mantenidos en bolsas plasticas, entonces un ensayo molecular fue usado con lo que permitio la deteccion de inmaduros de L. oregmae dentro de los hospederos de afidos inmediatamente despues de la recoleccion. El ensayo molecular fue usado en el 2003 con individuos del afido pardo de los citricos y con otras especies de afidos recolectados sobre citricos, malezas y hortalizas cerca de los sitios donde los parasitoides fueron liberados anteriormente; inmaduros de L. oregmae fueron detectados en individuos del afido negro de los citricos, el afido del caupi, el afido spirea y el afido del melon, ademas del afido pardo de los citricos en 4 de los 8 condados muestreados, con la tasa del parasitismo entre 2.0 a12.9%, indicando que L. oregmae estaba estabecido y ampliamente distribuido. Las muestras tomadas en el Condado de Polk durante octobre del 2005 indicaron que L. oregmae ha persistido. La capacidad de L. oregmae para parasitar otras especies de afidos sobre citricos y otros afidos sobre otras plantas hospederas, incrementa la capacidad de L. oregmae para persistir cuando las poblaciones del afido pardo de los citricos estan bajas. (author)« less

Fast and Simple Detection of Yersinia pestis Applicable to Field Investigation of Plague Foci

PubMed Central

Simon, Stéphanie; Demeure, Christian; Lamourette, Patricia; Filali, Sofia; Plaisance, Marc; Créminon, Christophe; Volland, Hervé; Carniel, Elisabeth

2013-01-01

Yersinia pestis, the plague bacillus, has a rodent-flea-rodent life cycle but can also persist in the environment for various periods of time. There is now a convenient and effective test (F1-dipstick) for the rapid identification of Y. pestis from human patient or rodent samples, but this test cannot be applied to environmental or flea materials because the F1 capsule is mostly produced at 37°C. The plasminogen activator (PLA), a key virulence factor encoded by a Y. pestis-specific plasmid, is synthesized both at 20°C and 37°C, making it a good candidate antigen for environmental detection of Y. pestis by immunological methods. A recombinant PLA protein from Y. pestis synthesized by an Escherichia coli strain was used to produce monoclonal antibodies (mAbs). PLA-specific mAbs devoid of cross-reactions with other homologous proteins were further cloned. A pair of mAbs was selected based on its specificity, sensitivity, comprehensiveness, and ability to react with Y. pestis strains grown at different temperatures. These antibodies were used to develop a highly sensitive one-step PLA-enzyme immunoassay (PLA-EIA) and an immunostrip (PLA-dipstick), usable as a rapid test under field conditions. These two PLA-immunometric tests could be valuable, in addition to the F1-disptick, to confirm human plague diagnosis in non-endemic areas (WHO standard case definition). They have the supplementary advantage of allowing a rapid and easy detection of Y. pestis in environmental and flea samples, and would therefore be of great value for surveillance and epidemiological investigations of plague foci. Finally, they will be able to detect natural or genetically engineered F1-negative Y. pestis strains in human patients and environmental samples. PMID:23383008

M.Y.S.P.A.C.E. : Multinational Youth Studying Practical Applications of Climatic Events

NASA Astrophysics Data System (ADS)

Mckay, M.; Arvedson, J. P.; Arvedson, P.

2014-12-01

M.Y. S.P.A.C.E. (Multinational Youth Studying Practical Applications of Climatic Events) is an international collaboration of high school students engaged in self-selected research projects on the local impact of global environmental issues. Students work with their own, trained, Teacher Leaders at their school sites using both locally generated and satellite-based remote-sensing data with support from the National Oceanic and Atmospheric Administration (NOAA) and the National Aeronautics and Space Administration (NASA). Teams from each school meet at the annual Satellites & Education Conference to discover global trends in their collective data and present their findings. Students learn and practice techniques of scientific investigation; methods of data processing, analysis and interpretation; leadership; and effective communication. They work with NOAA and NASA scientists and engineers, experience university campus life, and can apply for special internships at selected university research centers such as the Center for Energy and Sustainability (CE&S), the Center for Spatial Analysis and Remote Sensing (CSARS), and graduate research opportunities in Geosciences and Environment. The M.Y. S.P.A.C.E. Program is an initiative of the Satellites & Education Conference, which is produced by the non-profit Satellite Educators Association. It is administered from the campus of California State University, Los Angeles. NOAA, NASA, and the NOAA-CREST West grant support the program. It is aligned with NOAA goals of building excitement about careers in science, math, engineering and technology.

A study of the durability of beryllium rocket engines. [space shuttle reaction control system

NASA Technical Reports Server (NTRS)

Paster, R. D.; French, G. C.

1974-01-01

An experimental test program was performed to demonstrate the durability of a beryllium INTEREGEN rocket engine when operating under conditions simulating the space shuttle reaction control system. A vibration simulator was exposed to the equivalent of 100 missions of X, Y, and Z axes random vibration to demonstrate the integrity of the recently developed injector-to-chamber braze joint. An off-limits engine was hot fired under extreme conditions of mixture ratio, chamber pressure, and orifice plugging. A durability engine was exposed to six environmental cycles interspersed with hot-fire tests without intermediate cleaning, service, or maintenance. Results from this program indicate the ability of the beryllium INTEREGEN engine concept to meet the operational requirements of the space shuttle reaction control system.

EJSCREEN Version 1, Environmental Data

EPA Pesticide Factsheets

This map service displays raw environmental data for the 12 environmental indicators used in EJSCREEN. The map service displays percentiles for each of the environmental indicators to provide perspective on how a selected location compares to the entire nation. EJSCREEN is an environmental justice screening tool that provides EPA with a nationally consistent approach to screening for potential areas of EJ concern that may warrant further investigation. The EJ indexes are block group level results that combine multiple demographic factors with a single environmental variable (such as proximity to traffic) that can be used to help identify communities living with the greatest potential for negative environmental and health effects. The EJSCREEN tool is currently for internal EPA use only. It is anticipated that as users become accustomed to this new tool, individual programs within the Agency will develop program use guidelines and a community of practice will develop around them within the EPA Geoplatform. Users should keep in mind that screening tools are subject to substantial uncertainty in their demographic and environmental data, particularly when looking at small geographic areas, such as Census block groups. Data on the full range of environmental impacts and demographic factors in any given location are almost certainly not available directly through this tool, and its initial results should be supplemented with additional information and local knowledge