Appendix E. Analysis of Chronic Toxicity Data and Acute Chronic Ratios (ACRs) in Support of Deriving Chronic HC5s: Acetylcholinesterase Inhibitors

EPA Science Inventory

The analysis described in this appendix is one of several conducted in support of developing a common methodology for assessing chemical effects on aquatic animals for use by the USEPA Office of Pesticide Programs (OPP) and the Office of Water (OW). Other appendices describe met...

77 FR 26792 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... long-range planning. Agenda: Staff presentations and discussion on opportunities and challenges for polar research, education and infrastructure; discussion of OPP Strategic Vision and Committee of Visitors process. Dated: May 2, 2012. Susanne Bolton, Committee Management Officer. [FR Doc. 2012-10881...

USER MANUAL FOR EXPRESS, THE EXAMS-PRZM EXPOSURE SIMULATION SHELL

EPA Science Inventory

The Environmental Fate and Effects Division (EFED) of EPA's Office of Pesticide Programs(OPP) uses a suite of ORD simulation models for the exposure analysis portion of regulatory risk assessments. These models (PRZM, EXAMS, AgDisp) are complex, process-based simulation codes tha...

78 FR 40027 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... chromatography/ultraviolet (HPLC/UV) method) are available to enforce the tolerance expression. The method may be... available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER...

DEVELOPMENT OF A STRUCTURE-SEARCHABLE DATABASE FOR PESTICIDE METABOLITES AND ENVIRONMENTAL DEGRADATES

EPA Science Inventory

USEPA is modifying and enhancing existing software for the depiction of metabolic maps to provide access via structures to metabolism information and associated data in EPA's Office of Pesticide Programs (OPP). The database includes information submitted to EPA in support of pest...

75 FR 74713 - Product Cancellation Order for Certain Pesticide Registrations; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

...: Maia Tatinclaux, Pesticide Re- evaluation Division (7508P), Office of Pesticide Programs, Environmental... action to a particular entity, consult the person listed under FOR FURTHER INFORMATION CONTACT. B. How... action under docket identification (ID) number EPA-HQ-OPP-2010-0014. Publicly available docket materials...

78 FR 60720 - Methyl Parathion; Removal of Expired Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

...: This regulation is effective October 2, 2013. ADDRESSES: The docket for this action, identified by... the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection...-0001. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding...

75 FR 51036 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0597; FRL-8840-4] Pesticide Emergency Exemptions..., Fungicide, and Rodenticide Act (FIFRA) for use of pesticides as listed in this notice. The exemptions were...), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington...

77 FR 66834 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0019; FRL-9362-1] Pesticide Emergency Exemptions..., Fungicide, and Rodenticide Act (FIFRA) for use of pesticides as listed in this notice. The exemptions were...), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. NW., Washington, DC...

78 FR 21945 - Notice of Receipt of Pesticide Products; Registration Applications To Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0025; FRL-9383-7] Notice of Receipt of Pesticide...). ACTION: Notice. SUMMARY: This notice announces receipt of applications to register new uses for pesticide... mail. Mail correspondence to the Registration Division (7505P), Office of Pesticide Programs...

75 FR 53689 - Issuance of an Experimental Use Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-1016; FRL-8842-5] Issuance of an Experimental Use...-2009-1016. Publicly available docket materials are available either in the electronic docket at http... Pollution Prevention Division, Office of Pesticide Programs. [FR Doc. 2010-21716 Filed 8-31-10; 8:45 am...

How EPA Uses Dietary data from USDA for Exposure Assessments

USDA-ARS?s Scientific Manuscript database

Background: To present the procedures the US Environmental Protection Agency’s (EPA’s) Office of Pesticide Programs (OPP) uses to update the estimates of dietary exposure to pesticides using the consumption data from the National Health and Nutrition Survey, What We Eat in America and methodology a...

RapidTox - Tools for Rapid Risk Assessments (BOSC)

EPA Science Inventory

Risk assessments are needed for hundreds to thousands of chemicals, many of which do not have the rich data sets required, for instance, for IRIS or PPRTV assessments. EPA program offices and groups (OLEM, OPP Inerts, OPPT and others) still need to carry out to risk assessments f...

75 FR 19967 - Maneb; Cancellation Order for a Certain Pesticide Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... INFORMATION CONTACT: Barbara Briscoe, Pesticide Re- evaluation Division, Office of Pesticide Programs... questions regarding the applicability of this action to a particular entity, consult the person listed under... Information? EPA has established a docket for this action under docket identification (ID) number EPA-HQ-OPP...

76 FR 41247 - Product Cancellation Order for Certain Pesticide Registrations; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... Tatinclaux, Pesticide Re- evaluation Division (7508P), Office of Pesticide Programs, Environmental Protection... particular entity, consult the person listed under FOR FURTHER INFORMATION CONTACT. B. How can I get copies... docket identification (ID) number EPA-HQ-OPP-2009-1017. Publicly available docket materials are available...

75 FR 28012 - Pesticides; Draft Guidance for Pesticide Registrants on False or Misleading Pesticide Product...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... Pesticide Registrants on False or Misleading Pesticide Product Brand Names AGENCY: Environmental Protection... Pesticide Product Brand Names.'' PR Notices are issued by the Office of Pesticide Programs (OPP) to inform... concerning pesticide product brand names that may be false or misleading, either by themselves or in...

75 FR 54622 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0019; FRL-8843-8] Pesticide Emergency Exemptions..., Fungicide, and Rodenticide Act (FIFRA) for use of pesticides as listed in this notice. The exemptions were... Division (7505P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave., NW...

76 FR 28776 - Pesticide Reregistration Performance Measures and Goals; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... INFORMATION CONTACT: Carol P. Stangel, Pesticide Re- evaluation Division (7508P), Office of Pesticide Programs... entity, consult the person listed under FOR FURTHER INFORMATION CONTACT. B. How can I get copies of this... identification (ID) number EPA-HQ-OPP-2009-0909. Publicly available docket materials are available either in the...

Evaluation Processes of Regional and National Education Accrediting Agencies: Implications for Redesigning an Evaluation Process in California.

ERIC Educational Resources Information Center

Bernhardt, Victoria L.

Colleges and universities in California may be accredited or approved by four different agencies to offer approved programs of teacher education: the State Department of Education's Office of Private Postsecondary Education (OPPE) (for private institutions); the Western Association of Schools and Colleges (WASC); the Commission on Teacher…

Evolution of osteopathic graduate medical education: integration of osteopathic principles and practice in postdoctoral training.

PubMed

Lemley, William W; Steele, Karen M; Shires, William E; McMahan, Richard M

2007-11-01

Osteopathic principles and practice (OPP) are considered the core, distinguishing elements of the osteopathic medical profession. As such, the American Osteopathic Association introduced Osteopathic Postdoctoral Training Institutions (OPTIs) in 1995 to further incorporate OPP into osteopathic graduate medical education. The current study describes the evolution of the OPP teaching programs at the West Virginia School of Osteopathic Medicine (WVSOM) in Lewisburg in conjunction with its OPTI consortium, the Mountain State OPTI. Developments in distance-learning technology, lecture and workshop curricula for graduate and undergraduate students, and faculty training are described. In addition, elements of "telehealth" technology, including administrative support, and trainee and student evaluations of the programs are examined. It is hoped that the description of WVSOM's curricular evolution and the emphasis on meeting the needs of OPP program attendees will assist other osteopathic medical schools in developing their own unique OPP programs.

A set of scientific issues being considered by the Environmental Protection Agency regarding: pesticide exposure modeling and climate change. SAP Minutes No. 2011-01. USEPA FIFRA Scientific Advisory Panel

USDA-ARS?s Scientific Manuscript database

The USEPA Office of Pesticide Programs (OPP) reviewed most of its human and ecological exposure assessment models for conventional pesticides to evaluate which inputs and parameters may be affected by changing climate conditions. To illustrate the approach used for considering potential effects of c...

75 FR 51058 - Web-Distributed Labeling User Acceptance Pilot

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0632; FRL-8840-1] Web-Distributed Labeling User... Pesticide Programs (OPP) is exploring a new initiative called ``web-distributed labeling'' (web-distributed... Internet. Through this Federal Register Notice, OPP is announcing its intention to conduct a web...

The two-dimensional exposure rainfall-runoff assessment (TERRA)watershed model and its use in the FIFRA ecological risk assessment for antimicrobial uses of copper. FIFRA Scientific Advisory Panel Meeting; October 25-26.

USDA-ARS?s Scientific Manuscript database

The USEPA Office of Pesticide Programs (OPP) presented preliminary risk assessments of the two antimicrobial uses of copper during a public hearing held October 25-26, 2011 in Arlington, VA to a Scientific Advisory Panel convened the by the agency. In addition presentations were made on use of the ...

Carbon and Metal Transformations Near the Continent-Ocean Margin Quantified with the ZAPS Instrument Package

DTIC Science & Technology

1999-09-30

Rudnicki M.D. and Klinkhammer G.P., (1999) A segment-scale survey of the Broken Spur hydrothermal plume , Deep-Sea Res. I, 46, 701-714. Guay C.K...We used our sled this year to explore the Bransfield Strait, Antarctica for hydrothermal vent sites (NSF -Office of Polar Programs; OPP-9725872). We...used the real time sensing capability to locate a vent field and map hydrothermal signals at several locations. We used the ZAPS package to investigate

77 FR 61432 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... and infrastructure; discussion of OPP Strategic Vision and Committee of Visitors process. Dated..., to provide advice to the Director of OPP on issues related to merit review and long-range planning...

Polar advisory committee focuses on NSF realignment

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-11-01

With the U.S. National Science Foundation's (NSF) realignment that moves the agency's Office of Polar Programs (OPP) back to the Directorate for Geosciences (GEO), "the emphasis on the importance of the polar program at NSF doesn't change," NSF director Subra Suresh reassured members of the federal Advisory Committee on Polar Programs during a committee meeting on 5 November. "The polar program in its entirety stays as the same entity. Nothing changes," he told committee members, regarding the realignment that began on 1 October (see Eos, 93(43), 427, doi:10.1029/2012EO430003). "Nothing changes in terms of our commitment to the polar program. Nothing changes in terms of infrastructure support. Nothing changes in terms of people in the polar program speaking for the polar program to the external world and internally. And nothing changes in terms of how individual scientists interact with the polar program."

Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; Short Inpatient Hospital Stays; Transition for Certain Medicare-Dependent, Small Rural Hospitals Under the Hospital Inpatient Prospective Payment System; Provider Administrative Appeals and Judicial Review. Final rule with comment period; final rule.

PubMed

2015-11-13

This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2016 to implement applicable statutory requirements and changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system. In addition, this final rule with comment period updates and refines the requirements for the Hospital Outpatient Quality Reporting (OQR) Program and the ASC Quality Reporting (ASCQR) Program. Further, this document includes certain finalized policies relating to the hospital inpatient prospective payment system: Changes to the 2-midnight rule under the short inpatient hospital stay policy; and a payment transition for hospitals that lost their status as a Medicare-dependent, small rural hospital (MDH) because they are no longer in a rural area due to the implementation of the new Office of Management and Budget delineations in FY 2015 and have not reclassified from urban to rural before January 1, 2016. In addition, this document contains a final rule that finalizes certain 2015 proposals, and addresses public comments received, relating to the changes in the Medicare regulations governing provider administrative appeals and judicial review relating to appropriate claims in provider cost reports.

Injection drug users trained by overdose prevention programs: Responses to witnessed overdoses

PubMed Central

Lankenau, Stephen E.; Wagner, Karla D.; Silva, Karol; Kecojevic, Aleksander; Iverson, Ellen; McNeely, Miles; Kral, Alex H.

2012-01-01

In response to the growing public health problem of drug overdose, community-based organizations have initiated overdose prevention programs (OPP), which distribute naloxone, an opioid antagonist, and teach overdose response techniques. Injection drug users (IDUs) have been targeted for this intervention due to their high risk for drug overdose. Limited research attention has focused on factors that may inhibit or prevent IDUs who have been trained by OPPs to undertake recommended response techniques when responding to a drug overdose. IDUs (n=30) trained by two OPPs in Los Angeles were interviewed in 2010–11 about responses to their most recently witnessed drug overdose using an instrument containing both open and closed-ended questions. Among the 30 witnessed overdose events, the victim recovered in 29 cases while the outcome was unknown in one case. Participants responded to overdoses using a variety of techniques taught by OPP. Injecting the victim with naloxone was the most common recommended response while other recommended responses included stimulating the victim with knuckles, calling 911, and giving rescue breathing. Barriers preventing participants from employing recommended response techniques in certain circumstances included prior successes using folk remedies to revive a victim, concerns over attracting police to the scene, and issues surrounding access to or use of naloxone. Practical solutions, such as developing booster sessions to augment OPP, are encouraged to increase the likelihood that trained participants respond to a drug overdose with the full range of recommended techniques. PMID:22847602

Use of Toxicogenomic Data at the US EPA to Inform the Cancer Asessment of the Fungicide Propiconazole

EPA Science Inventory

The Office of Pesticide Programs’ (OPP) routinely utilizes mode of action (MOA) data when available for pesticide cancer risk assessment. A MOA analysis incorporates data from required toxicology studies and supplemental mechanistic data. These data are evaluated to identify a ...

77 FR 31355 - Aldicarb; Cancellation Order for Amendments To Terminate Uses; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... FURTHER INFORMATION CONTACT: Susan Bartow, Pesticide Re-evaluation Division (7508P), Office of Pesticide... action to a particular entity, consult the person listed under FOR FURTHER INFORMATION CONTACT. B. How... action under docket identification (ID) number EPA-HQ-OPP-2005-0163. Publicly available docket materials...

ATRAZINE ECOLOGICAL EFFECTS ASSESSMENT FOR OPP LEVEL OF CONCERN AND OW WATER QUALITY CRITERION FOR AQUATIC LIFE

EPA Science Inventory

Atrazine is a relatively water-soluble and persistent herbicide that can reach concentrations of possible ecological concern for aquatic plants in vulnerable watersheds in regions with high agricultural usage of atrazine. As a consequence, the U.S. EPA Office of Water is current...

A set of scientific issues being considered by the United States Environmental Protection Agency regarding pollinator risk assessment framework.

USDA-ARS?s Scientific Manuscript database

On September 11-14, 2012, the US Environmental Protection Agency convened a public meeting of the FIFRA Scientific Advisory Panel (SAP) to address scientific issues associated with the Office of Pesticides Program’s (OPP) proposed “Pollinator Risk Assessment Framework”. Several sources have reporte...

Susceptibility of nine organophosphorus pesticides in skimmed milk towards inoculated lactic acid bacteria and yogurt starters.

PubMed

Zhou, Xin-Wei; Zhao, Xin-Huai

2015-01-01

Previous research has shown that fresh milk might be polluted by some organophosphorus pesticides (OPPs). In this study the dissipation of nine OPPs, namely chlorpyrifos, chlorpyrifos-methyl, diazinon, dichlorvos, fenthion, malathion, phorate, pirimiphos-methyl and trichlorphon, in skimmed milk was investigated to clarify their susceptibility towards lactic acid bacteria (LAB) and yogurt starters. Skimmed milk was spiked with nine OPPs, inoculated with five strains of LAB and two commercial yogurt starters at 42 °C for 24 and 5 h respectively and subjected to quantitative OPP analysis by gas chromatography. Degradation kinetic constants of these OPPs were calculated based on a first-order reaction model. OPP dissipation in the milk was enhanced by the inoculated strains and starters, resulting in OPP concentrations decreasing by 7.0-64.6 and 7.4-19.2% respectively. Totally, the nine OPPs were more susceptible to Lactobacillus bulgaricus, as it enhanced their degradation rate constants by 18.3-133.3%. Higher phosphatase production of the assayed stains was observed to bring about greater OPP degradation in the milk. Both LAB and yogurt starters could enhance OPP dissipation in skimmed milk, with the nine OPPs studied having different susceptibilities towards them. Phosphatase was a key factor governing OPP dissipation. The LAB of higher phosphatase production have more potential to decrease OPPs in fermented foods. © 2014 Society of Chemical Industry.

Promoting Tobacco Cessation and Smoke-Free Workplaces Through Community Outreach Partnerships in Puerto Rico

PubMed Central

Díaz-Toro, Elba C.; Fernández, Maria E.; Correa-Fernández, Virmarie; Calo, William A.; Ortiz, Ana Patricia; Mejía, Luz M.; Mazas, Carlos A.; Santos-Ortiz, María del Carmen; Wetter, David W.

2014-01-01

Background Puerto Rico (PR) has a lower smoking prevalence than the United States (14.8% vs. 21.2%, respectively); nevertheless, the five leading causes of death are associated with smoking. There is a need to implement evidence-based tobacco control strategies in PR. Objectives The Outreach Pilot Program (OPP) was designed to engage communities, health professionals, and researchers in a network to advance health promotion activities and research to increase the use of the PR Quitline (PRQ) among smokers and promoting policies in support of smoke-free workplaces. Methods Using community-based participatory research (CBPR) methods, the OPP mobilized a network of community and academic partners to implement smoking cessation activities including referrals to the PRQ, adoption of evidence-based smoking cessation programs, and promotion of smoke-free legislation. Results Eighty organizations participated in the OPP. Collaborators implemented activities that supported the promotion of the PRQ and smoke-free workplaces policy and sponsored yearly trainings, including tobacco control conferences. From 2005 to 2008, physician referrals to the PRQ increased from 2.6% to 7.2%. The number of annual smokers receiving cessation services through the PRQ also increased from 703 to 1,086. The OPP shepherded a rigorous smoke-free law through participation in the development, promotion, and implementation of the smoke-free workplaces legislation as well as the creation of the PR Tobacco Control Strategic Plan, launched in 2006. Conclusions This project demonstrates the feasibility of developing a successful and sustainable community-based outreach program model that enlists the participation of academic researchers, community organizations, and health care providers as partners to promote tobacco control. PMID:25152097

Scientific Applications of two U.S. Antarctic Program Projects at NSIDC

NASA Astrophysics Data System (ADS)

Scharfen, G. R.; Bauer, R. J.

2001-12-01

The National Snow and Ice Data Center maintains two Antarctic science data management programs supporting both the efforts of Principal Investigators (PIs), and the science that is funded by the NSF Office of Polar Programs. These programs directly relate to the OPP "Guidelines and Award Conditions for Scientific Data", which identify the conditions for awards and responsibilities of PIs regarding the archival of data, and submission of metadata, resulting from their NSF OPP grants. The U.S. Antarctic Data Coordination Center (USADCC) is funded by NSF to assist PIs as they meet these requirements, and to provide a U.S. focal point for the Antarctic Master Directory, a web-based searchable directory of Antarctic scientific data. The USADCC offers access to free, easy-to-use online tools that PIs can use to create the data descriptions that the NSF policy data requires. We provide advice to PIs on how to meet the data policy requirements, and can answer specific questions on related issues. Scientists can access data set descriptions submitted to the Antarctic Master Directory, by thousands of scientists around the world, from the USADCC web pages. The USADCC website is at http://nsidc.org/NSF/USADCC/. The Antarctic Glaciological Data Center (AGDC) is funded by NSF to archive and distribute data collected by the NSF Antarctic Glaciology Program and related cryospheric investigations. The AGDC contains data sets collected by individual investigators on specific grants, and compiled products assembled from many different PI data sets, published literature, and other sources. Data sets are available electronically and include access to the data, plus useful documentation, citation information about the PI(s), locator maps, derived images and references. The AGDC website is at http://nsidc.org/NSF/AGDC/. The utility of both of these projects for scientists is illustrated by a typical user-driven case study to research, obtain and use Antarctic data for a science application.

76 FR 19793 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

... presentations and discussion on opportunities and challenges for polar research, education and infrastructure; discussion of OPP Strategic Vision development; transformative research, ad hoc proposals & program... advise NSF on the impact of its policies, programs, and [[Page 19794

NOAA Office of Exploration and Research > About OER > 2014 Funding

Science.gov Websites

Room OER Symposium OER FY 2014 Federal Funding Opportunity: Closed Pre-Proposals were due on November 4 is the OER formal public announcement requesting pre-proposals and full proposals for fiscal year 2014. For the full FFO go to http://www.grants.gov/view-opportunity.html?oppId=243154. Pre-proposals

75 FR 65385 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... Antarctic Program review; Strategic Planning; planning for a Polar Research Vessel. Dated: October 19, 2010... research community, to provide advice to the Director of OPP on issues related to long-range planning...

The Biological and Chemical Oceanography Data Management Office

NASA Astrophysics Data System (ADS)

Allison, M. D.; Chandler, C. L.; Groman, R. C.; Wiebe, P. H.; Glover, D. M.; Gegg, S. R.

2011-12-01

Oceanography and marine ecosystem research are inherently interdisciplinary fields of study that generate and require access to a wide variety of measurements. In late 2006 the Biological and Chemical Oceanography Sections of the National Science Foundation (NSF) Geosciences Directorate Division of Ocean Sciences (OCE) funded the Biological and Chemical Oceanography Data Management Office (BCO-DMO). In late 2010 additional funding was contributed to support management of research data from the NSF Office of Polar Programs Antarctic Organisms & Ecosystems Program. The BCO-DMO is recognized in the 2011 Division of Ocean Sciences Sample and Data Policy as one of several program specific data offices that support NSF OCE funded researchers. BCO-DMO staff members offer data management support throughout the project life cycle to investigators from large national programs and medium-sized collaborative research projects, as well as researchers from single investigator awards. The office manages and serves all types of oceanographic data and information generated during the research process and contributed by the originating investigators. BCO-DMO has built a data system that includes the legacy data from several large ocean research programs (e.g. United States Joint Global Ocean Flux Study and United States GLOBal Ocean ECosystems Dynamics), to which data have been contributed from recently granted NSF OCE and OPP awards. The BCO-DMO data system can accommodate many different types of data including: in situ and experimental biological, chemical, and physical measurements; modeling results and synthesis data products. The system enables reuse of oceanographic data for new research endeavors, supports synthesis and modeling activities, provides availability of "real data" for K-12 and college level use, and provides decision-support field data for policy-relevant investigations. We will present an overview of the data management system capabilities including: map-based and text-based data discovery and access systems; recent enhancements to data search tools; data export and download utilities; and strategic use of controlled vocabularies to facilitate data integration and to improve data system interoperability.

OPPE, FPPE, QPS, and why the alphabet soup of physician assessment is essential for safer patient care.

PubMed

Loftus, Michael L

Creating a successful quality and patient safety program requires a multifaceted approach that systematically reviews overall systems and processes, but also creates a standardized framework for evaluating individual practitioner performance on a routine basis. There are two required elements of competency assessment that are typically tied to the hospital credentialing process: ongoing professional practice evaluation (OPPE) and focused professional practice evaluation (FPPE). Each of these processes are mandated by the Joint Commission, and form an important cornerstone for ensuring adequate physician performance and knowledge base. Copyright © 2017. Published by Elsevier Inc.

75 FR 65363 - Basic Behavioral and Social Science Opportunity Network (OppNet)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... public meeting to promote and publicize the Basic Behavioral and Social Science Opportunity Network (Opp... . Background: The Basic Behavioral and Social Science Opportunity Network (OppNet) is a trans-NIH initiative to expand the agency's funding of basic behavioral and social sciences research (b-BSSR). OppNet prioritizes...

Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes

PubMed Central

2011-01-01

Background Plant phenolics are important nutritional antioxidants which could aid in overcoming chronic diseases such as cardiovascular disease and cancer, two leading causes of death in the world. The oil palm (Elaeis guineensis) is a rich source of water-soluble phenolics which have high antioxidant activities. This study aimed to identify the in vivo effects and molecular mechanisms involved in the biological activities of oil palm phenolics (OPP) during healthy states via microarray gene expression profiling, using mice supplemented with a normal diet as biological models. Results Having confirmed via histology, haematology and clinical biochemistry analyses that OPP is not toxic to mice, we further explored the gene expression changes caused by OPP through statistical and functional analyses using Illumina microarrays. OPP showed numerous biological activities in three major organs of mice, the liver, spleen and heart. In livers of mice given OPP, four lipid catabolism genes were up-regulated while five cholesterol biosynthesis genes were down-regulated, suggesting that OPP may play a role in reducing cardiovascular disease. OPP also up-regulated eighteen blood coagulation genes in spleens of mice. OPP elicited gene expression changes similar to the effects of caloric restriction in the hearts of mice supplemented with OPP. Microarray gene expression fold changes for six target genes in the three major organs tested were validated with real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and the correlation of fold changes obtained with these two techniques was high (R2 = 0.9653). Conclusions OPP showed non-toxicity and various pleiotropic effects in mice. This study implies the potential application of OPP as a valuable source of wellness nutraceuticals, and further suggests the molecular mechanisms as to how dietary phenolics work in vivo. PMID:21864415

Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes.

PubMed

Leow, Soon-Sen; Sekaran, Shamala Devi; Sundram, Kalyana; Tan, YewAi; Sambanthamurthi, Ravigadevi

2011-08-25

Plant phenolics are important nutritional antioxidants which could aid in overcoming chronic diseases such as cardiovascular disease and cancer, two leading causes of death in the world. The oil palm (Elaeis guineensis) is a rich source of water-soluble phenolics which have high antioxidant activities. This study aimed to identify the in vivo effects and molecular mechanisms involved in the biological activities of oil palm phenolics (OPP) during healthy states via microarray gene expression profiling, using mice supplemented with a normal diet as biological models. Having confirmed via histology, haematology and clinical biochemistry analyses that OPP is not toxic to mice, we further explored the gene expression changes caused by OPP through statistical and functional analyses using Illumina microarrays. OPP showed numerous biological activities in three major organs of mice, the liver, spleen and heart. In livers of mice given OPP, four lipid catabolism genes were up-regulated while five cholesterol biosynthesis genes were down-regulated, suggesting that OPP may play a role in reducing cardiovascular disease. OPP also up-regulated eighteen blood coagulation genes in spleens of mice. OPP elicited gene expression changes similar to the effects of caloric restriction in the hearts of mice supplemented with OPP. Microarray gene expression fold changes for six target genes in the three major organs tested were validated with real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and the correlation of fold changes obtained with these two techniques was high (R2 = 0.9653). OPP showed non-toxicity and various pleiotropic effects in mice. This study implies the potential application of OPP as a valuable source of wellness nutraceuticals, and further suggests the molecular mechanisms as to how dietary phenolics work in vivo.

75 FR 18551 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... Visitors meetings; transformative research; and strategic planning. Dated: April 7, 2010. Susanne Bolton... OPP on issues related to long-range planning. Agenda: Staff presentations and discussion on...

Arterial and intraocular pressure changes after a single-session hot-water immersion.

PubMed

Findikoglu, Gulin; Cetin, Ebru Nevin; Sarsan, Ayse; Senol, Hande; Yildirim, Cem; Ardic, Fusun

2015-01-01

The aim of this study is to investigate the effect of head-out hot-water immersion on the intraocular pressure (IOP) of healthy subjects and investigate whether this intervention alters cardiovascular and microcirculatory responses. METHODs: 16 male and 18 female healthy young adults were immersed in 39 degrees C water up to shoulder level for 20 minutes. Blood pressure (BP), heart rate (HR) and IOP were measured pre-immersion, post-immersion and five minutes after immersion on the same day. Tono-Pen was used to measure IOP. Mean arterial blood pressure (MAP), systolic pressure rate product (S-PRP), diastolic pressure rate product (D-PRP), pulse pressure (PP), mean ocular perfusion pressure (mean-OPP), systolic ocular perfusion pressure (S-OPP) and diastolic ocular perfusion pressure (D-OPP) were calculated. Systolic BP (SBP), diastolic BP (DBP), MAP, IOP, S-OPP, D-OPP and mean-OPP decreased; HR increased five minutes after immersion in the pool and post-immersion out of the pool significantly, compared to pre-immersion data (p < 0.05). HR, S-PRP and D-PRP measured five minutes after immersion were significantly higher from post-immersion (p < 0.05). PP and S-OPP were significantly different five minutes after immersion compared to pre-immersion. There was no statistically significant correlation between IOP and SBP, DBP, MAP, S-PRP, D-PRP, PP, S-OPP, D-OPP, or mean-OPP (p > 0.05). Physiological hemodynamic response to single head-out hot-water immersion caused a statistically significant decrease in IOP. Preliminary results could help to clarify vascular reactions and IOP changes during hot-water immersion that might be potentially therapeutic in glaucoma patients.

Role of NO in the control of choroidal blood flow during a decrease in ocular perfusion pressure.

PubMed

Simader, Christian; Lung, Solveig; Weigert, Günther; Kolodjaschna, Julia; Fuchsjäger-Mayrl, Gabriele; Schmetterer, Leopold; Polska, Elzbieta

2009-01-01

The study was conducted to investigate whether the L-arginine/nitric oxide system plays a role in choroidal blood flow (ChBF) regulation during a decrease in ocular perfusion pressure (OPP). Experiments were performed on 3 days in a randomized double-masked, placebo-controlled, three-way crossover design. On different study days, subjects received intravenous infusions of N(G)-monomethyl-L-arginine (L-NMMA), phenylephrine, or placebo. Intraocular pressure was raised in stepwise increments using the suction cup Choroidal blood flow (ChBF, laser Doppler flowmetry), mean arterial blood pressure (MAP), and IOP were assessed. Ocular perfusion pressure was calculated as OPP = 23(MAP - IOP). For correlation analysis all OPP/ChBF data pairs from all subjects were pooled independent of time point of measurement. Then, the pooled data were sorted according to OPP, and correlation analyses were performed. L-NMMA and phenylephrine increased resting OPP by +17% +/- 18% and +14% +/- 21%, respectively (P < 0.05). L-NMMA reduced resting ChBF by -21% +/- 17% (P < 0.05). The relative decrease in OPP during suction cup application was comparable with all drugs administered. The decrease in OPP was paralleled by a significant decrease in ChBF (maximum between -39% and -47%), which was less pronounced, however, than the decrease in OPP (maximum between -69% and -74%). Neither placebo nor L-NMMA, nor phenylephrine, influenced the OPP/ChBF relationship. The data confirm previously published observations that the choroid shows some regulatory capacity during reduced OPP. The L-arginine/nitric oxide-system plays a role in the maintenance of basal vascular tone but seems not to be involved in the choroidal vasodilator response when IOP is increased.

Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.

PubMed

Musilek, Kamil; Dolezal, Martin; Gunn-Moore, Frank; Kuca, Kamil

2011-07-01

Organophosphate pesticides (OPPs; e.g. chlorpyrifos, diazinon, paraoxon) are a wide and heterogeneous group of organophosphorus compounds. Their biological activity of inhibiting acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) ranks them as life endangering agents. The necessary treatment after OPP exposure involves the use of parasympatolytics (e.g. atropine), oxime reactivators (e.g. obidoxime), and anticonvulsive drugs (e.g. diazepam). Therefore, the reactivators of AChE are essential compounds in the treatment of OPP intoxications. Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE. Obidoxime and trimedoxime showed satisfactory reactivation against various OPPs with minor toxicity issues. During the last two decades, the treatment of OPP exposure has become more widely discussed because of growing agricultural production, industrialization, and harmful social issues (e.g. suicides). In this review is the summarized design, evaluation, and structure-activity relationship studies of recently produced AChE reactivators. Since pralidoxime, over 300 oximes have been produced or tested against OPP poisoning, and several novel compounds show very promising abilities as comparable (or higher) to commercial oximes. Some of these are highlighted for their further testing of OPP exposure and, additionally, the main structure-activity relationship of AChE reactivators against OPP is discussed. © 2009 Wiley Periodicals, Inc.

Organophosphate pesticide in agricultural soils from the Yangtze River Delta of China: concentration, distribution, and risk assessment.

PubMed

Pan, Lili; Sun, Jianteng; Li, Zhiheng; Zhan, Yu; Xu, Shen; Zhu, Lizhong

2018-01-01

Organophosphorus pesticides (OPPs) are used worldwide and pose great risks to human health. However, information on their presence in agricultural soils at regional scale and the associated risks is limited. In this study, an extensive investigation on agricultural soils was conducted throughout the Yangtze River Delta (YRD) of China to reveal the status of OPP pollution. The total concentrations of the nine OPPs ranged from <3.0 to 521 ng g -1 dry weight, with a mean of 64.7 ng g -1 dry weight and a detection rate of 93 %. Dimethoate was found to be the primary compound, followed by methyl parathion and parathion. The highest concentrations of OPPs were found in Jiangsu province due to the intensive agricultural activities. The pollution of OPPs is also highly associated with the land use types. The lower concentrations of OPPs found in vegetable fields could be attributed to their easy photodegradation and hydrolysis in aerobic soils. There was no significant difference in microbial communities among the sample sites, indicating that OPPs in agricultural soils of the YRD region cause negligible effects on microbiota. The risks of OPPs in the soils to human health were further evaluated. The hazard indexes in all the soil samples were below 1, suggesting absence of non-cancer risks. This study provides valuable information for a better understanding of the pollution status of OPPs in agricultural soils and a scientific basis for soil quality assessments.

Comparison of choroidal and optic nerve head blood flow regulation during changes in ocular perfusion pressure.

PubMed

Schmidl, Doreen; Boltz, Agnes; Kaya, Semira; Werkmeister, Rene; Dragostinoff, Nikolaus; Lasta, Michael; Polska, Elzbieta; Garhöfer, Gerhard; Schmetterer, Leopold

2012-07-01

We compared the response of choroidal and optic nerve head blood flow (ChBF, ONHBF) in response to an increase in ocular perfusion pressure (OPP) during isometric exercise and during a decrease in OPP during an artificial increase in intraocular pressure (IOP). We included 96 healthy subjects in our study. In 48 subjects OPP was increased by 6 minutes of squatting, and either ONHBF (n = 24) or ChBF (n = 24) was measured continuously. In 48 other healthy subjects either ONHBF (n = 24) or ChBF (n = 24) was measured continuously during a period of artificial increase in IOP using a suction cup. All blood flow measurements were done using laser Doppler flowmetry. During all experiments the response in blood flow was less pronounced than the response in OPP, indicating for flow regulation. During isometric exercise ChBF regulated better than ONHBF (P = 0.023). During artificial IOP increase ONHBF regulated better than ChBF (P = 0.001). Inter-individual variability in blood flow responses was high. During squatting ONHBF decreased considerably below baseline ONHBF when OPP fluctuated in 3 subjects, although OPP still was much higher than at baseline. This phenomenon was not observed in the choroid. Our data indicate that regulation of ChBF and ONHBF during changes in OPP is different and complex. In some subjects performing squatting, considerable ONHBF reductions were observed during OPP fluctuations, although OPP still was high. Whether this predisposes to ocular disease remains unclear.

Recommendations to Minimize Timely Payment Problems of Subcontractors Involved in Private and Public Building Construction in Pennsylvania.

DTIC Science & Technology

1982-05-01

Thomas P. Kuchar 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Stddent,HDQA, MILPERCEN (DAPC-OPP-E) AREA 6 WORK UNIT...of Financing ................................... 50 Business Practice Information Interchange .................. 50 Program Description...51 Other Types of Credit Exchange Programs .................... 52 Chapter Summary ............................................ 53 IV REM-EDY OPTIONS

Common Effects Methodology for Pesticides

EPA Pesticide Factsheets

EPA is exploring how to build on the substantial high quality science developed under both OPP programs to develop additional tools and approaches to support a consistent and common set of effects characterization methods using best available information.

Integrating Research and Education in NSF's Office of Polar Programs

NASA Astrophysics Data System (ADS)

Wharton, R. A.; Crain, R. D.

2003-12-01

The National Science Foundation invests in activities that integrate research and education, and that develop reward systems to support teaching, mentoring and outreach. Effective integration of research and education at all levels can infuse learning with the excitement of discovery. It can also ensure that the findings and methods of research are quickly and effectively communicated in a broader context and to a larger audience. This strategy is vital to the accomplishment of NSF's strategic goals of ensuring a world-class science and engineering workforce, new knowledge across the frontiers of science and engineering, and the tools to get the job done efficiently and effectively. The NSF's Office of Polar Programs sponsors educational projects at all levels of learning, making full use of the variety of disciplinary and interdisciplinary studies in the polar regions to attract and invigorate students. An array of efforts from the Arctic and Antarctic scientific communities link research activities with education. There has been an advance from the beneficial but isolated impacts of individual researcher visits to K-12 classrooms to large-scale developments, such as field research experiences for teachers and undergraduate students, online sharing of polar field experiences with rural classrooms, the institution of interdisciplinary graduate research programs through NSF initiatives, and opportunities for minority and underrepresented groups in polar sciences. The NSF's criterion for evaluating proposals based upon the broader impacts of the research activity has strengthened efforts to link research and education, resulting in partnerships and innovations that infuse research into education from kindergarten through postdoctoral studies and reaching out to the general public. In addition, the Office of Polar Programs partners with other directorates at NSF to broaden OPP's efforts and benefit from resources and experience in the Education and Human Resources Directorate, the Geosciences Education program, the Environmental Research and Education program and others. This presentation will provide an overview of the direction of science education in the Office of Polar Programs and highlight some important and long-lasting ventures. It is intended to encourage the Arctic and Antarctic scientific communities to look for additional avenues to bridge their research with education.

Immune response to oligopeptide permease A (OppA) protein in pigs naturally and experimentally infected with Haemophilus parasuis.

PubMed

Macedo, Nubia; Oliveira, Simone; Torremorell, Montserrat; Rovira, Albert

2016-08-01

Haemophilus parasuis is an important swine pathogen that causes Glasser's disease, characterized by pneumonia, polyserositis and meningitis. Protection against H. parasuis infection is associated with the presence of homologous antibodies in serum. However, a H. parasuis antigen that can elicit a protective immune response against all H. parasuis strains has yet to be found. A novel immunogenic and species-specific H. parasuis protein was identified by screening H. parasuis whole cell proteins using swine convalescent sera. One protein of 52kDa was clearly immunodominant and conserved among different H. parasuis strains. This protein was further identified as an oligopeptide permease A (OppA). Because OppA elicited a specific antibody response in pigs that recovered from H. parasuis infection, we investigated its potential role in diagnostics and protective immunity. An ELISA test using recombinant OppA (rOppA) as its coating antigen was further developed and tested. H. parasuis specific antibodies to rOppA were detected in serum from convalescent pigs but not in serum from specific pathogen free (SPF) or conventional pigs. Pigs immunized with rOppA protein had robust serological responses. However, the antibodies were not protective against challenge infection. We conclude that OppA is a universal species-specific H. parasuis immunogen, and a good marker for previous systemic infection with H. parasuis. Copyright © 2016. Published by Elsevier Ltd.

Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol

PubMed Central

Nde, Chantal W; Jang, Hyeung-Jin; Toghrol, Freshteh; Bentley, William E

2008-01-01

Background Pseudomonas aeruginosa (P. aeruginosa) is the most common opportunistic pathogen implicated in nosocomial infections and in chronic lung infections in cystic fibrosis patients. Ortho-phenylphenol (OPP) is an antimicrobial agent used as an active ingredient in several EPA registered disinfectants. Despite its widespread use, there is a paucity of information on its target molecular pathways and the cellular responses that it elucidates in bacteria in general and in P. aeruginosa in particular. An understanding of the OPP-driven gene regulation and cellular response it elicits will facilitate more effective utilization of this antimicrobial and possibly lead to the development of more effective disinfectant treatments. Results Herein, we performed a genome-wide transcriptome analysis of the cellular responses of P. aeruginosa exposed to 0.82 mM OPP for 20 and 60 minutes. Our data indicated that OPP upregulated the transcription of genes encoding ribosomal, virulence and membrane transport proteins after both treatment times. After 20 minutes of exposure to 0.82 mM OPP, genes involved in the exhibition of swarming motility and anaerobic respiration were upregulated. After 60 minutes of OPP treatment, the transcription of genes involved in amino acid and lipopolysaccharide biosynthesis were upregulated. Further, the transcription of the ribosome modulation factor (rmf) and an alternative sigma factor (rpoS) of RNA polymerase were downregulated after both treatment times. Conclusion Results from this study indicate that after 20 minutes of exposure to OPP, genes that have been linked to the exhibition of anaerobic respiration and swarming motility were upregulated. This study also suggests that the downregulation of the rmf and rpoS genes may be indicative of the mechanism by which OPP causes decreases in cell viability in P. aeruginosa. Consequently, a protective response involving the upregulation of translation leading to the increased synthesis of membrane related proteins and virulence proteins is possibly induced after both treatment times. In addition, cell wall modification may occur due to the increased synthesis of lipopolysaccharide after 60 minutes exposure to OPP. This gene expression profile can now be utilized for a better understanding of the target cellular pathways of OPP in P. aeruginosa and how this organism develops resistance to OPP. PMID:18847467

Disability management practices in Ontario workplaces: employees' perceptions.

PubMed

Westmorland, Muriel G; Williams, Renee M; Amick, Ben C; Shannon, Harry; Rasheed, Farah

2005-07-22

The purpose of this study was to obtain employees' perceptions about disability management (DM) at their workplaces. Data were obtained from focus group interviews and individual telephone interviews with 58 employees who had sustained a work-related injury or disability in Ontario, Canada. Participants also completed a 22-item Organizational Policies and Practices (OPP) Questionnaire that asked questions about workplace DM practices. Respondents emphasized the need for job accommodation, the importance of open and clear communication and the necessity of job retraining. The provision of ergonomic modifications to their worksites and the development of meaningful and specific DM policies and procedures were seen as key to a comprehensive workplace DM program. Education about health and safety also was identified as an important component of creating a supportive workplace environment. The OPP questionnaire showed good internal consistency (Cronbach's alpha=0.95) and discriminant validity. This study demonstrates the importance of workplaces communicating with their employees and respecting their opinions when establishing and carrying out DM policies and practices. The OPP Questionnaire is useful in determining how DM is managed in the workplace.

Phaseolotoxin transport in Escherichia coli and Salmonella typhimurium via the oligopeptide permease.

PubMed Central

Staskawicz, B J; Panopoulos, N J

1980-01-01

Phaseolotoxin [(N delta-phosphosulfamyl)ornithylalanylhomoarginine], a phytotoxic tripeptide produced by Pseudomonas syringae pv. phaseolicola that inhibits ornithine carbamoyltransferase, is transported into Escherichia coli and Salmonella typhimurium via the oligopeptide transport system (Opp). Mutants defective in oligopeptide permease (Opp-) were resistant to phaseolotoxin. Spontaneous phaseolotoxin-resistant mutants (Toxr) lacked the Opp function as evidenced by their cross-resistance to triornithine and failure to utilize glycylhistidylglycine as a source of histidine. Growth inhibition by phaseolotoxin was prevented by peptides known to be transported via the Opp system and by treatment of the toxin with L-aminopeptidase. In both E. coli and S. typhimurium, Toxr mutations were cotransducible with trp, suggesting that the opp locus occupies similar positions in genetic maps of these bacteria. PMID:6991475

“I Felt Like a Superhero”: The Experience of Responding to Drug Overdose Among Individuals Trained in Overdose Prevention

PubMed Central

Wagner, Karla D.; Davidson, Peter J.; Iverson, Ellen; Washburn, Rachel; Burke, Emily; Kral, Alex H.; McNeeley, Miles; Bloom, Jennifer Jackson; Lankenau, Stephen E.

2013-01-01

Background Overdose prevention programs (OPPs) train people who inject drugs and other community members to prevent, recognise and respond to opioid overdose. However, little is known about the experience of taking up the role of an “overdose responder” for the participants. Methods We present findings from qualitative interviews with 30 participants from two OPPs in Los Angeles, CA, USA from 2010–2011 who had responded to at least one overdose since being trained in overdose prevention and response. Results Being trained by an OPP and responding to overdoses had both positive and negative effects for trained “responders”. Positive effects include an increased sense of control and confidence, feelings of heroism and pride, and a recognition and appreciation of one’s expertise. Negative effects include a sense of burden, regret, fear, and anger, which sometimes led to cutting social ties, but might also be mitigated by the increased empowerment associated with the positive effects. Conclusion Findings suggest that becoming an overdose responder can involve taking up a new social role that has positive effects, but also confers some stress that may require additional support. OPPs should provide flexible opportunities for social support to individuals making the transition to this new and critical social role. Equipping individuals with the skills, technology, and support they need to respond to drug overdose has the potential to confer both individual and community-wide benefits. PMID:23932166

Common Effects Methodology National Stakeholder Meeting December 1, 2010

EPA Pesticide Factsheets

EPA is exploring how to build on the substantial high quality science developed under both OPP programs to develop additional tools and approaches to support a consistent and common set of effects characterization methods using best available information.

Confirmatory Factor and Rasch Analyses Support a Revised 14-Item Version of the Organizational, Policies, and Practices (OPP) Scale.

PubMed

Shi, Qiyun; MacDermid, Joy C; Tang, Kenneth; Sinden, Kathryn E; Walton, Dave; Grewal, Ruby

2017-06-01

Background The long version of the organizational, policies and practices (OPP) had a high burden and short versions were developed to solve this drawback. The 11-item version showed promise, but the ergonomic subscale was deficient. The OPP-14 was developed by adding three additional items to the ergonomics subscale. The aim of this study is to evaluate the factor structure using confirmatory factor and Rasch analyses in healthy firefighters. Methods A sample of 261 firefighters (Mean age 42 years, 95 % male) were sampled. A confirmatory factor and Rasch analyses were used to assess the internal consistency, factor structure and other psychometric characteristics of revised OPP-14. Results The OPP-14 demonstrates sound factor structure and internal consistency in firefighters. Confirmatory factor analysis confirmed the consistency of the original 4-domain structure (CFI = 0.97, TLI = 0.96, and RMSEA = 0.053). The 5 items showing misfit initially with disordered thresholds were rescored. The four subscales satisfied Rasch expectations with well target and acceptable reliability. Conclusions The OPP-14 scale shows a promising factor structure in this sample and remediated deficits found in OPP-11. This version may be preferable for musculoskeletal concerns or work applications where ergonomic indicators are relevant.

Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance.

PubMed

Wang, Guohong; Li, Dan; Ma, Xiayin; An, Haoran; Zhai, Zhengyuan; Ren, Fazheng; Hao, Yanling

2015-08-01

Lactobacillus salivarius is a member of the indigenous microbiota of the human gastrointestinal tract (GIT), and some L. salivarius strains are considered as probiotics. Bile tolerance is a crucial property for probiotic bacteria to survive the transit through the GIT and exert their beneficial effects. In this work, the functional role of oppA encoding an oligopeptide transporter substrate-binding protein from L. salivarius Ren in bile salt tolerance was investigated. In silico analysis revealed that the oppA gene encodes a 61.7-kDa cell surface-anchored hydrophilic protein with a canonical lipoprotein signal peptide. Homologous overexpression of OppA was shown to confer 20-fold higher tolerance to 0.5 % oxgall in L. salivarius Ren. Furthermore, the recombinant strain exhibited 1.8-fold and 3.6-fold higher survival when exposed to the sublethal concentration of sodium taurocholate and sodium taurodeoxycholate, respectively, while no significant change was observed when exposed to sodium glycocholate and sodium glycodeoxycholate (GDCA). Our results indicate that OppA confers specific resistance to taurine-conjugated bile salts in L. salivarius Ren. In addition, the OppA overexpression strain also showed significant increased resistance to heat and salt stresses, suggesting the protective role of OppA against multiple stresses in L. salivarius Ren.

Medicare and Medicaid programs: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; electronic reporting pilot; Inpatient Rehabilitation Facilities Quality Reporting Program; revision to Quality Improvement Organization regulations. Final rule with comment period.

PubMed

2012-11-15

This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2013 to implement applicable statutory requirements and changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system. In addition, this final rule with comment period updates and refines the requirements for the Hospital Outpatient Quality Reporting (OQR) Program, the ASC Quality Reporting (ASCQR) Program, and the Inpatient Rehabilitation Facility (IRF) Quality Reporting Program. We are continuing the electronic reporting pilot for the Electronic Health Record (EHR) Incentive Program, and revising the various regulations governing Quality Improvement Organizations (QIOs), including the secure transmittal of electronic medical information, beneficiary complaint resolution and notification processes, and technical changes. The technical changes to the QIO regulations reflect CMS' commitment to the general principles of the President's Executive Order on Regulatory Reform, Executive Order 13563 (January 18, 2011).

Common Effects Methodology National Stakeholder Meeting December 1, 2010 White Papers

EPA Pesticide Factsheets

EPA is exploring how to build on the substantial high quality science developed under both OPP programs to develop additional tools and approaches to support a consistent and common set of effects characterization methods using best available information.

Common Effects Methodology Regional Stakeholder Meeting January 11 -22, 2010

EPA Pesticide Factsheets

EPA is exploring how to build on the substantial high quality science developed under both OPP programs to develop additional tools and approaches to support a consistent and common set of effects characterization methods using best available information.

Zirconium(IV) functionalized magnetic nanocomposites for extraction of organophosphorus pesticides from environmental water samples.

PubMed

Jiang, Li; Huang, Tengjun; Feng, Shun; Wang, Jide

2016-07-22

The widespread use of organophosphate pesticides (OPPs) in agriculture leads to residue accumulation in the environment which is dangerous to human health and disrupts the ecological balance. In this work, one nanocomposite immobilized zirconium (Zr, IV) was prepared and used as the affinity probes to quickly and selectively extract organophosphorus pesticides (OPPs) from water samples. The Fe3O4-ethylenediamine tetraacetic acid (EDTA)@Zr(IV) nanocomposites (NPs) were prepared by simply mixing Zr(IV) ions with Fe3O4-EDTA NPs synthesized by one-pot chemical co-precipitation method. The immobilized Zr(IV) ions were further utilized to capture OPPs based on their high affinity for the phosphate moiety in OPPs. Coupled with GC-MS, four OPPs were used as models to demonstrate the feasibility of this approach. Under the optimum conditions, the limits of detection for target OPPs were in the range of 0.10-10.30ngmL(-1) with relative standard deviations (RSDs) of 0.61-4.40% (n=3), respectively. The linear ranges were over three orders of magnitudes (correlation coefficients, R(2)>0.9995). The Fe3O4-EDTA@Zr(IV) NPs were successfully applied to extract OPPs samples with recoveries of 86.95-112.60% and RSDs of 1.20-10.42% (n=3) from two spiked real water. By the proposed method, the matrix interference could be effectively eliminated. We hope our finding can provide a promising alternative for the fast extraction of OPPs from complex real samples. Copyright © 2016 Elsevier B.V. All rights reserved.

Impact of organizational policies and practices on workplace injuries in a hospital setting.

PubMed

Tveito, T H; Sembajwe, G; Boden, L I; Dennerlein, J T; Wagner, G R; Kenwood, C; Stoddard, A M; Reme, S E; Hopcia, K; Hashimoto, D; Shaw, W S; Sorensen, G

2014-08-01

This study aimed to assess relationships between perceptions of organizational practices and policies (OPP), social support, and injury rates among workers in hospital units. A total of 1230 hospital workers provided survey data on OPP, job flexibility, and social support. Demographic data and unit injury rates were collected from the hospitals' administrative databases. Injury rates were lower in units where workers reported higher OPP scores and high social support. These relationships were mainly observed among registered nurses. Registered nurses perceived coworker support and OPP as less satisfactory than patient care associates (PCAs). Nevertheless, because of the low number of PCAs at each unit, results for the PCAs are preliminary and should be further researched in future studies with larger sample sizes. Employers aiming to reduce injuries in hospitals could focus on good OPP and supportive work environment.

Microarray analysis of toxicogenomic effects of Ortho-phenylphenol in Staphylococcus aureus

PubMed Central

Jang, Hyeung-Jin; Nde, Chantal; Toghrol, Freshteh; Bentley, William E

2008-01-01

Background Staphylococcus aureus (S. aureus), is responsible for many infectious diseases, ranging from benign skin infections to life-threatening endocarditis and toxic shock syndrome. Ortho-phenylphenol (OPP) is an antimicrobial agent and an active ingredient of EPA-registered disinfectants with wide human exposure in various agricultural, hospital and veterinary disinfectant products. Despite many uses, an understanding of a cellular response to OPP and it's mechanism of action, targeted genes, and the connectivity between targeted genes and the rest of cell metabolism remains obscure. Results Herein, we performed a genome-wide transcriptome analysis of the cellular responses of S. aureus when exposed to 0.82 mM of OPP for 20 and 60 min. Our data indicated that OPP downregulated the biosynthesis of many amino acids, which are required for protein synthesis. In particular, the genes encoding the enzymes of the diaminopimelate (DAP) pathway which results in lysine biosynthesis were significantly downregualted. Intriguingly, we revealed that the transcription of genes encoding ribosomal proteins was upregulated by OPP and at the same time, the genes encoding iron acquisition and transport were downregulated. The genes encoding virulence factors were upregulated and genes encoding phospholipids were downregulated upon 20 min exposure to OPP. Conclusion By using microarray analysis that enables us to simultaneously and globally examine the complete transcriptome during cellular responses, we have revealed novel information regarding the mode of action of OPP on Staphylococcus: OPP inhibits anabolism of many amino acids and highly downregulates the genes that encode the enzymes involved in the DAP pathway. Lysine and DAP are essential for building up the peptidoglycan cell wall. It was concluded that the mode of action of OPP is similar to the mechanism of action of some antibiotics. The discovery of this phenomenon provides useful information that will benefit further antimicrobial research on S. aureus. PMID:18793396

The CELSS Antarctic Analog Project: an advanced life support testbed at the Amundsen-Scott South Pole Station, Antarctica.

PubMed

Straight, C L; Bubenheim, D L; Bates, M E; Flynn, M T

1994-01-01

The Controlled Ecological Life Support System (CELSS) Antarctic Analog Project (CAAP) is a joint endeavor between the National Science Foundation, Office of Polar Programs (NSF-OPP) and the National Aeronautics and Space Administration (NASA). Its fundamental objective is to develop, deploy and operate a testbed of NASA CELSS technologies and life support approaches at the Amundsen-Scott South Pole Station, located at latitude 90 degrees S, longitude 0 degrees. The goal of NASA's CELSS Program is to develop technologies and systems that will allow spacefaring scientists and explorers to carry out long duration extraterrestrial missions, leading ultimately to permanent habitation of the Solar System, without total dependence on a costly resupply system. A CELSS would do this by providing regenerated life support materials (air, food and water) and by processing "waste" materials into useful resources. This will be accomplished using biological and physical/chemical techniques in a nearly closed environmental habitation system. CELSS technologies also have great implications for application to terrestrial systems with intrinsic transferability to society at large. The CELSS Program intends to provide opportunities for the transfer of these systems and technologies outside the US Space Program, to applications within the American economy as space technology spin-offs.

78 FR 74825 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment and Ambulatory Surgical...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

..., for issues related to OPPS pass-through devices, brachytherapy sources, intraoperative radiation... cardioverter defibrillator ICU Intensive care unit IHS Indian Health Service IMRT Intensity Modulated Radiation... Intraoperative radiation treatment IPPS [Hospital] Inpatient Prospective Payment System IQR [Hospital] Inpatient...

Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice

PubMed Central

Leow, Soon-Sen; Sekaran, Shamala Devi; Tan, YewAi; Sundram, Kalyana; Sambanthamurthi, Ravigadevi

2013-01-01

Objectives Phenolics are important phytochemicals which have positive effects on chronic diseases, including neurodegenerative ailments. The oil palm (Elaeis guineensis) is a rich source of water-soluble phenolics. This study was carried out to discover the effects of administering oil palm phenolics (OPP) to mice, with the aim of identifying whether these compounds possess significant neuroprotective properties. Methods OPP was given to BALB/c mice on a normal diet as fluids for 6 weeks while the controls were given distilled water. These animals were tested in a water maze and on a rotarod weekly to assess the effects of OPP on cognitive and motor functions, respectively. Using Illumina microarrays, we further explored the brain gene expression changes caused by OPP in order to determine the molecular mechanisms involved. Real-time quantitative reverse transcription-polymerase chain reaction experiments were then carried out to validate the microarray data. Results We found that mice given OPP showed better cognitive function and spatial learning when tested in a water maze, and their performance also improved when tested on a rotarod, possibly due to better motor function and balance. Microarray gene expression analysis showed that these compounds up-regulated genes involved in brain development and activity, such as those under the regulation of the brain-derived neurotrophic factor. OPP also down-regulated genes involved in inflammation. Discussion These results suggest that the improvement of mouse cognitive and motor functions by OPP is caused by the neuroprotective and anti-inflammatory effects of the extract. PMID:23433062

75 FR 60113 - Pesticide Science Policy; Notice of Withdrawal

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0935; FRL-8804-7] Pesticide Science Policy... announces the withdrawal of the pesticide science policy document ``Use of the Pesticide Data Program (PDP... of data and different models. This science policy document was developed to explain a particular...

76 FR 10584 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... ">[email protected] epa.gov . 2. PP 0E7802. (EPA-HQ-OPP-2010-1018). Interregional Research Project Number 4 (IR....gov ">[email protected] epa.gov . 3. PP 0E7804. (EPA-HQ-OPP-2010-0472). Interregional Research Project No....gov ">[email protected] epa.gov . 4. PP 0E7809. (EPA-HQ-OPP-2010-1017). Interregional Research Project No...

Purification and crystallization of the ABC-type transport substrate-binding protein OppA from Thermoanaerobacter tengcongensis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Jinlan; Li, Xiaolu; Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, People's Republic of China

2012-06-22

Highlights: Black-Right-Pointing-Pointer We truncated the signal peptide of OppA{sub TTE0054} to make it express in Escherichia coli as a soluble protein. Black-Right-Pointing-Pointer Crystals of OppA{sub TTE0054} were grown by sitting-drop vapor diffusion method. Black-Right-Pointing-Pointer The crystal of OppA{sub TTE0054} diffracted to 2.25 A. -- Abstract: Di- and oligopeptide- binding protein OppAs play important roles in solute and nutrient uptake, sporulation, biofilm formation, cell wall muropeptides recycling, peptide-dependent quorum-sensing responses, adherence to host cells, and a variety of other biological processes. Soluble OppA from Thermoanaerobacter tengcongensis was expressed in Escherichia coli. The protein was found to be >95% pure with SDS-PAGEmore » after a series of purification steps and the purity was further verified by mass spectrometry. The protein was crystallized using the sitting-drop vapour-diffusion method with PEG 400 as the precipitant. Crystal diffraction extended to 2.25 A. The crystal belonged to space group C222{sub 1}, with unit-cell parameters of a = 69.395, b = 199.572, c = 131.673 A, and {alpha} = {beta} = {gamma} = 90 Degree-Sign .« less

Pharmacokinetics of 14 C-ortho-phenylphenol following intravenous administration in pigs.

PubMed

Nixon, Emma; Brooks, James D; Routh, Patricia A; Chittenden, Jason T; Baynes, Ronald E

2017-04-01

Workers in the USA are exposed to industrial formulations, which may be toxic. These formulations often contain preservatives or biocides such as ortho-phenylphenol (OPP). There are limited data describing OPP following intravenous administration to assess truly the clearance of this chemical in humans and other species. In vivo experiments were conducted in pigs to determine related pharmacokinetic parameters. 14 C-OPP was administered as an intravenous bolus dose. Blood, feces, urine and tissue samples were collected for analysis by liquid scintillation. Data were analyzed using non-compartmental and compartmental pharmacokinetic model approaches. These data fitted a three-compartment model and showed that the half-life of 14 C-OPP following the intravenous bolus in pigs was 46.26 ± 10.01 h. The kidneys play a crucial role in clearance of 14 C-OPP with a large percentage of the dose being found in the urine (70.3 ± 6.9% dose). Comparisons with other species suggest that 14 C-OPP clearance in pigs (2.48 ml h -1  kg -1 ) is less than that in humans (18.87 ml h -1  kg -1 ) and rats (35.51 ml h -1  kg -1 ). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Here comes the Sun Shine: Industry's Payments to Cardiothoracic Surgeons

PubMed Central

Hicks, Caitlin W.; Orandi, Babak J.; Atallah, Chady; Chow, Eric K.; Massie, Allan B.; Lopez, Joseph; Higgins, Robert S.; Segev, Dorry L.

2016-01-01

Background The Physician Payment Sunshine Act (PPSA) was implemented to provide transparency to financial transactions between industry and physicians. Under this law, the Open Payments Program (OPP) was created to publicly disclose all transactions and inform patients of potential conflicts-of-interest (COI). Collaboration between industry and cardiothoracic surgeon-scientists is essential in developing new approaches to treating patients with cardiac disease. The objective of this study is to characterize industry payments to cardiothoracic surgeons as reported by OPP. Methods We used the first wave of PPSA data (August 2013-December 2013) to assess industry payments made to cardiothoracic surgeons. Results Cardiothoracic surgeons (N=2,495) received a total of $4,417,545 during a five-month period. Cardiothoracic surgeons comprised of 0.5% of all individuals in the OPP and received 0.9% of total disclosed industry funding. Among cardiothoracic surgeons receiving funding, 34% received payments <$100, 43% received payments of $100-$999, 19% received payments of $1,000-$9,999, 4% received payments of $10,000-$99,999 and 0.2% received payments >$100,000. The median (IQR) was $181 (60-843) and the mean (±SD) was $1,771 (±7,664). The largest payment to an individual was $159,444. The three largest median (IQR) payments made to cardiothoracic surgeons by expense category were royalty fees $8,398 (536-12,316), speaker fees $3,600 (1,500-8,000), and Honoraria $3,344 (1,563-7,350). Conclusions Among cardiothoracic surgeons who are listed as recipients of non-research industry payments, 50% of cardiothoracic surgeons received <$181. Awareness of the OPP data is critical for cardiothoracic surgeons, as it provides a means to prevent potential public misconceptions about industry payments within the specialty that may affect patient trust. PMID:27353195

Improving Sprint Performance in Soccer: Effectiveness of Jump Squat and Olympic Push Press Exercises

PubMed Central

Loturco, Irineu; Pereira, Lucas Adriano; Kobal, Ronaldo; Maldonado, Thiago; Piazzi, Alessandro Fromer; Bottino, Altamiro; Kitamura, Katia; Cal Abad, Cesar Cavinato; de Arruda, Miguel; Nakamura, Fabio Yuzo

2016-01-01

Training at the optimum power load (OPL) is an effective way to improve neuromuscular abilities of highly trained athletes. The purpose of this study was to test the effects of training using the jump squat (JS) or Olympic push-press (OPP) exercises at the OPL during a short-term preseason on speed-power related abilities in high-level under-20 soccer players. The players were divided into two training groups: JS group (JSG) and OPP group (OPPG). Both groups undertook 12 power-oriented sessions, using solely JS or OPP exercises. Pre- and post-6 weeks of training, athletes performed squat jump (SJ), countermovement jump (CMJ), sprinting speed (5, 10, 20 and 30 m), change of direction (COD) and speed tests. To calculate the transfer effect coefficient (TEC) between JS and MPP OPP and the speed in 5, 10, 20, and 30 m, the ratio between the result gain (effect size [ES]) in the untrained exercise and result gain in the trained exercise was calculated. Magnitude based inference and ES were used to test the meaningful effects. The TEC between JS and VEL 5, 10, 20, and 30 m ranged from 0.77 to 1.29, while the only TEC which could be calculated between OPP and VEL 5 was rather low (0.2). In addition, the training effects of JS on jumping and speed related abilities were superior (ES ranging from small to large) to those caused by OPP (trivial ES). To conclude, the JS exercise is superior to the OPP for improving speed-power abilities in elite young soccer players. PMID:27100085

Improving Sprint Performance in Soccer: Effectiveness of Jump Squat and Olympic Push Press Exercises.

PubMed

Loturco, Irineu; Pereira, Lucas Adriano; Kobal, Ronaldo; Maldonado, Thiago; Piazzi, Alessandro Fromer; Bottino, Altamiro; Kitamura, Katia; Cal Abad, Cesar Cavinato; de Arruda, Miguel; Nakamura, Fabio Yuzo

2016-01-01

Training at the optimum power load (OPL) is an effective way to improve neuromuscular abilities of highly trained athletes. The purpose of this study was to test the effects of training using the jump squat (JS) or Olympic push-press (OPP) exercises at the OPL during a short-term preseason on speed-power related abilities in high-level under-20 soccer players. The players were divided into two training groups: JS group (JSG) and OPP group (OPPG). Both groups undertook 12 power-oriented sessions, using solely JS or OPP exercises. Pre- and post-6 weeks of training, athletes performed squat jump (SJ), countermovement jump (CMJ), sprinting speed (5, 10, 20 and 30 m), change of direction (COD) and speed tests. To calculate the transfer effect coefficient (TEC) between JS and MPP OPP and the speed in 5, 10, 20, and 30 m, the ratio between the result gain (effect size [ES]) in the untrained exercise and result gain in the trained exercise was calculated. Magnitude based inference and ES were used to test the meaningful effects. The TEC between JS and VEL 5, 10, 20, and 30 m ranged from 0.77 to 1.29, while the only TEC which could be calculated between OPP and VEL 5 was rather low (0.2). In addition, the training effects of JS on jumping and speed related abilities were superior (ES ranging from small to large) to those caused by OPP (trivial ES). To conclude, the JS exercise is superior to the OPP for improving speed-power abilities in elite young soccer players.

75 FR 45769 - Medicare Program; Changes to the Hospital Outpatient Prospective Payment System and Ambulatory...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-03

... 2010 OPPS/ASC final rule, we estimated that pass-through spending for both drugs and biologicals and... pass through drugs and non-implantable biologicals, and device categories and the proportion of... and implantable biologicals), ``policy packaged'' drugs (diagnostic radiopharmaceuticals and contrast...

Comparison of Four Probabilistic Models (CARES, Calendex, ConsEspo, SHEDS) to Estimate Aggregate Residential Exposures to Pesticides

EPA Science Inventory

Two deterministic models (US EPA’s Office of Pesticide Programs Residential Standard Operating Procedures (OPP Residential SOPs) and Draft Protocol for Measuring Children’s Non-Occupational Exposure to Pesticides by all Relevant Pathways (Draft Protocol)) and four probabilistic mo...

76 FR 81496 - Product Cancellation Order for Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... ). 010807-00123 Misty Flea Killer... Phenothrin. 010807-00151 One Shot ``foamy'' Alkyl*dimethylbenzyl... Programs (OPP) Regulatory Public Docket in Rm. S- 4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr... list of registrations for which companies paying at one of the maintenance fee caps requested...

How Do Organizational Policies and Practices Affect Return to Work and Work Role Functioning Following a Musculoskeletal Injury?

PubMed

Amick, Benjamin C; Lee, Hyunmi; Hogg-Johnson, Sheilah; Katz, Jeffrey N; Brouwer, Sandra; Franche, Renée-Louise; Bültmann, Ute

2017-09-01

Purpose Organizational-level policies and practices that promote safety leadership and practices, disability management and ergonomic policies and practices are considered key contextual determinants of return to work. Our objective was to examine the role of worker-reported organizational policies and practices (OPPs) in return to work (RTW) and work role functioning (WRF) and the mediating role of pain self-efficacy and work accommodation. Methods A worker cohort (n = 577) in Ontario, Canada was followed at 1, 6 and 12 months post injury. Both RTW (yes/no) and WRF (WLQ-16) status (3 levels) were measured. OPPs were measured (high vs. low) at 1 month post-injury. Pain self-efficacy (PSE) and work accommodation (WA) were included in mediation analyses. Results OPPs predicted RTW at 6 months (adjusted OR 1.77; 95 % CI 1.07-2.93) and 12 months (adjusted OR 2.07; 95 % CI 1.18-3.62). OPPs predicted WRF at 6 months, but only the transition from working with limitations to working without limitations (adjusted OR 3.21; 95 % CI 1.92-5.39). At 12 months, OPPs predicted both the transition from not working to working with and without limitations and from not working or working with limitations to working without limitations (adjusted OR 2.13; 95 % CI 1.37-3.30). Offers of WA mediated the relationship between OPPs and both RTW and WRF at 6 months follow-up. PSE mediated the relationship between OPPs and RTW and WRF at 6 months. At 12 months neither mediated the relationship. Conclusions The findings support worker-reported OPPs as key determinants of both RTW and WRF. These results point to the importance of WA and PSE in both RTW and WRF at 6 months.

Experimental evaluation of outer planets probe thermal insulation concepts

NASA Technical Reports Server (NTRS)

Grote, M. G.; Mezines, S. A.

1976-01-01

An experimental program was conducted to evaluate various thermal insulation concepts for use in the Outer Planets Probe (OPP) during entry and descent into the atmospheres of Jupiter, Saturn, and Uranus. Phenolic fiberglass honeycomb specimens representative of the OPP structure were packed and tested with various fillers: Thermal conductivity measurements were made over a temperature range of 300 K to 483 K and pressures from vacuum up to 10 atmospheres in helium and nitrogen gas environments. The conductivity results could not be fully explained so new test specimens were designed with improved venting characteristics, and tested to determine the validity of the original data. All of the conductivity data showed results that were substantially higher than expected. The original test data in helium were lower than the data from the redesigned specimens, probably due to inadequate venting of nitrogen gas from the original specimens. The thermal conductivity test results show only a marginal improvement in probe thermal protection performance for a filled honeycomb core compared to an unfilled core. In addition, flatwise tension tests showed a severe bond strength degradation due to the inclusion of either the powder or foam fillers. In view of these results, it is recommended that the baseline OPP design utilize an unfilled core.

Relevance of Peptide Uptake Systems to the Physiology and Virulence of Streptococcus agalactiae

PubMed Central

Samen, Ulrike; Gottschalk, Birgit; Eikmanns, Bernhard J.; Reinscheid, Dieter J.

2004-01-01

Streptococcus agalactiae is a major cause of invasive infections in human newborns. To satisfy its growth requirements, S. agalactiae takes up 9 of the 20 proteinogenic amino acids from the environment. Defined S. agalactiae mutants in one or several of four putative peptide permease systems were constructed and tested for peptide uptake, growth in various media, and expression of virulence traits. Oligopeptide uptake by S. agalactiae was shown to be mediated by the ABC transporter OppA1-F, which possesses two substrate-binding proteins (OppA1 and OppA2) with overlapping substrate specificities. Dipeptides were found to be taken up in parallel by the oligopeptide permease OppA1-F, by the dipeptide ABC transporter DppA-E, and by the dipeptide symporter DpsA. Reverse transcription-PCR analysis revealed a polycistronic organization of the genes oppA1-F and dppA-E and a monocistronic organization of dpsA in S. agalactiae. The results of quantitative real-time PCR revealed a medium-dependent expression of the operons dppA-E and oppA1-F in S. agalactiae. Growth of S. agalactiae in human amniotic fluid was shown to require an intact dpsA gene, indicating an important role of DpsA during the infection of the amniotic cavity by S. agalactiae. Deletion of the oppB gene reduced the adherence of S. agalactiae to epithelial cells by 26%, impaired its adherence to fibrinogen and fibronectin by 42 and 33%, respectively, and caused a 35% reduction in expression of the fbsA gene, which encodes a fibrinogen-binding protein in S. agalactiae. These data indicate that the oligopeptide permease is involved in modulating virulence traits and virulence gene expression in S. agalactiae. PMID:14973032

Effect of interscalene block on intraocular pressure and ocular perfusion pressure.

PubMed

Basaran, Betul; Yilbas, Aysun Ankay; Gultekin, Zeki

2017-10-23

Interscalene block (ISB) is commonly associated with Horner's syndrome due to spread of local anesthetic to the cervical sympathetic chain. Postganglionic neurons that originate from superior cervical ganglia form the sympathetic innervation of eye. Decrease in sympathetic tone may change intraocular pressure (IOP) and ocular perfusion pressure (OPP). The aim of the study was to investigate whether ISB affects IOP and/or OPP. Thirty patients scheduled for ambulatory shoulder surgery under regional anesthesia with a single-shot ISB (15 mL 0.5% bupivacaine and 15 mL 2% lidocaine) were recruited. The IOP and OPP in both eyes, mean arterial pressure (MAP), heart rate (HR) and end-tidal CO 2 (ETCO 2 ) were measured before ISB and 5, 10, 20, 30 and 60 min after ISB in the beach-chair position. The baseline IOP and OPP were similar in the blocked and unblocked sides (IOP 17.60 ± 1.69 and 17.40 ± 1.96 respectively p = 0.432; OPP 49.80 ± 8.20 and 50 ± 8.07 respectively p = 0.432). The IOP in the blocked side significantly decreased between 10th to 60th min following ISB, compared to the baseline values (p < 0.001). The OPP in the blocked side significantly increased from 10th to 60th min (p < 0.001) whereas, there were no significant changes in IOP and OPP throughout the measurement period in the unblocked side. ISB decreased IOP in the blocked side. ISB could be considered as a safe regional technique of choice in elderly patients at high risk for developing glaucoma.

Jump Squat is More Related to Sprinting and Jumping Abilities than Olympic Push Press.

PubMed

Loturco, I; Kobal, R; Maldonado, T; Piazzi, A F; Bottino, A; Kitamura, K; Abad, C C C; Pereira, L A; Nakamura, F Y

2017-07-01

The aim of this study was to test the relationships between jump squat (JS) and Olympic push press (OPP) power outputs and performance in sprint, squat jump (SJ), countermovement jump (CMJ) and change of direction (COD) speed tests in elite soccer players. 27 athletes performed a maximum power load test to determine their bar mean propulsive power (MPP) and bar mean propulsive velocity (MPV) in the JS and OPP exercises. Magnitude-based inference was used to compare the exercises. The MPV was almost certainly higher in the OPP than in the JS. The MPP relative to body mass (MPP REL) was possibly higher in the OPP. Only the JS MPP REL presented very large correlations with linear speed ( r> 0.7, for speed in 5, 10, 20 and 30 m) and vertical jumping abilities ( r> 0.8, for SJ and CMJ), and moderate correlation with COD speed ( r= 0.45). Although significant (except for COD), the associations between OPP outcomes and field-based measurements (speed, SJ and CMJ) were all moderate, ranging from 0.40 to 0.48. In a group composed of elite soccer players, the JS exercise is more associated with jumping and sprinting abilities than the OPP. Longitudinal studies are needed to confirm if these strong relationships imply superior training effects in favor of the JS exercise. © Georg Thieme Verlag KG Stuttgart · New York.

The relationship between organizational policies and practices and work limitations among hospital patient care workers.

PubMed

Sparer, Emily H; Boden, Leslie I; Sorensen, Glorian; Dennerlein, Jack T; Stoddard, Anne; Wagner, Gregory R; Nagler, Eve M; Hashimoto, Dean M; Hopcia, Karen; Sabbath, Erika L

2018-05-29

We examined relationships between organizational policies and practices (OPPs) (safety practices, ergonomic practices, and people-oriented culture) and work limitations in a sample of hospital workers. We used the 6-item Work Limitations Questionnaire (WLQ) to assess workers' perceptions of health-related work limitations. Self-reported OPPs and the WLQ were collected from workers in Boston, Massachusetts (n = 1277). We conducted random-intercept multi-level logistic regression models for each OPP using stepwise selection of covariates. As the unit-average ergonomic practice score increased by one, the odds of a worker reporting work limitations decreased by approximately 39% (P-value = 0.018), adjusted for job title, age, and body mass index. A similar relationship existed for people-oriented culture (P-value = 0.038). The association between safety practices and work limitations was similar, but not statistically significant. This study demonstrated the importance of workplace OPPs. OPPs that promote positive and supportive environments and that foster improvements in ergonomics may help reduce work limitations. © 2018 Wiley Periodicals, Inc.

Predictive relationship of osteopathic manual medicine grades and COMLEX-USA Level 1 total scores and osteopathic principles and practice subscores.

PubMed

Lewis, Drew D; Johnson, Mary T; Finnerty, Edward P

2014-06-01

Osteopathic manual medicine (OMM) encompasses hands-on diagnosis and treatment as part of patient care. The area of osteopathic principles and practice (OPP) is considered a core competency for students and practitioners of this medical tradition. The Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) is a useful tool for assessing candidates' competency. To examine the relationship of COMLEX-USA Level 1 total scores and OPP subscores with OMM course grades, and to determine if these grades are predictive of COMLEX-USA Level 1 OPP performance. The authors collected data-COMLEX-USA Level 1 total and OPP subscores, OMM grades (written, practical, and total for first and second academic years), sex, and age-for a cohort of osteopathic medical students at a single institution, and these data were then analyzed by means of correlation analysis. Records were obtained from a second-year class of osteopathic medical students (N=217). The authors' analysis of total scores and OPP subscores on COMLEX-USA Level 1 yielded a statistically significant correlation with all variables. Although the correlations were moderate, second-year written examination grades showed the strongest association with the COMLEX-USA Level 1 OPP subscores (r=0.530) and total scores (r=0.566). Performance in the second-year OMM written examination could identify students potentially at risk for poor performance on COMLEX-USA Level 1. © 2014 The American Osteopathic Association.

Effect of nifedipine on choroidal blood flow regulation during isometric exercise.

PubMed

Schmidl, Doreen; Prinz, Ana; Kolodjaschna, Julia; Polska, Elzbieta; Luksch, Alexandra; Fuchsjager-Mayrl, Gabriele; Garhofer, Gerhard; Schmetterer, Leopold

2012-01-25

To determine whether nifedipine, an L-type calcium channel blocker, alters choroidal blood flow (ChBF) regulation during isometric exercise in healthy subjects. The study was carried out in a randomized, placebo-controlled, double-masked, two-way crossover design. Fifteen healthy male subjects were randomly assigned to receive either placebo or nifedipine on two different study days. Subfoveal ChBF was measured with laser Doppler flowmetry while the study participants performed isometric exercise (squatting). This was performed before drug administration and during infusion of nifedipine and placebo, respectively. Mean arterial pressure (MAP) and intraocular pressure (IOP) were measured noninvasively, and ocular perfusion pressure (OPP) was calculated as ⅔ MAP-IOP. MAP and OPP increased significantly during all squatting periods (P < 0.01). The increase in ChBF was less pronounced than the increase in OPP during isometric exercise. Nifedipine did not alter the OPP increase in response to isometric exercise, but it significantly augmented the exercise-induced increase in ChBF (P < 0.001 vs. placebo). Although ChBF increased by a maximum of 14.2% ± 9.2% during the squatting period when placebo was administered, the maximum increase during administration of nifedipine was 23.2% ± 7.2%. In conclusion, the data of the present study suggest that nifedipine augments the ChBF response to an experimental increase in OPP. In addition, it confirms that the choroidal vasculature has a significant regulatory capacity over wide ranges of OPPs during isometric exercise. (ClinicalTrials.gov number, NCT00280462.).

A tool to enhance occupational therapy reasoning from ICF perspective: The Hasselt Occupational Performance Profile (H-OPP).

PubMed

Ghysels, R; Vanroye, E; Westhovens, M; Spooren, A

2017-03-01

In order to enhance occupational therapy reasoning in clinical practice, different elements such as client-centred approach, evidence-based care and interdisciplinary work should be taken into account, but is a challenge. To describe the development of the digital Hasselt Occupational Performance Profile (H-OPP © ) that enhances occupational therapy reasoning from ICF perspective. A participative qualitative design was used to create the H-OPP © in an iterative way in which occupational therapy lectures, ICF experts, students and occupational therapists in the field were involved. After linking occupational therapy terminology to the ICF, different stages of the H-OPP were identified and elaborated with main features: generating an occupational performance profile based on inventarization of problems and possibilities, formulating an occupational performance diagnosis and enabling to create an intervention plan. In all stages, both the perspectives of the client and the occupational therapist were taken into account. To increase practical use, the tool was further elaborated and digitalized. The H-OPP © is a digital coach that guides and facilitates professional reasoning in (novice) occupational therapists. It augments involvement of the client system. Furthermore, it enhances interdisciplinary communication and evidence-based care.

Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria.

PubMed

Agarwal, Shalini; Sharma, Vijeta; Phulera, Swastik; Abdin, M Z; Ayana, R; Singh, Shailja

2015-12-01

Carotenoids represent a diverse group of pigments derived from the common isoprenoid precursors and fulfill a variety of critical functions in plants and animals. Phytoene synthase (PSY), a transferase enzyme that catalyzes the first specific step in carotenoid biosynthesis plays a central role in the regulation of a number of essential functions mediated via carotenoids. PSYs have been deeply investigated in plants, bacteria and algae however in apicomplexans it is poorly studied. In an effort to characterize PSY in apicomplexans especially the malaria parasite Plasmodium falciparum (P. falciparum), a detailed bioinformatics analysis is undertaken. We have analysed the Phylogenetic relationship of PSY also referred to as octaprenyl pyrophosphate synthase (OPPS) in P. falciparum with other taxonomic groups. Further, we in silico characterized the secondary and tertiary structures of P. falciparum PSY/OPPS and compared the tertiary structures with crystal structure of Thermotoga maritima (T. maritima) OPPS. Our results evidenced the resemblance of P. falciparum PSY with the active site of T. maritima OPPS. Interestingly, the comparative structural analysis revealed an unconserved unique loop in P. falciparum OPPS/PSY. Such structural insights might contribute novel accessory functions to the protein thus, offering potential drug targets.

76 FR 38149 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... programs) (444220 Retail Nursery, Lawn, and Garden Supply stores, 424910 Agricultural chemicals merchant...- 2010-0723, to (1) EPA online using http://www.regulations.gov (our preferred method), or by mail to... this ICR under Docket ID No. EPA-HQ-OPP-2010-0723, which is available for online viewing at http//: www...

Identification of a new genetic marker in Mycoplasma synoviae vaccine strain MS-H and development of a strategy using polymerase chain reaction and high-resolution melting curve analysis for differentiating MS-H from field strains.

PubMed

Zhu, Ling; Konsak, Barbara M; Olaogun, Olusola M; Agnew-Crumptona, Rebecca; Kanci, Anna; Marenda, Marc S; Browning, Glenn F; Noormohammadi, Amir H

2017-10-01

Mycoplasma synoviae (MS) is an economically important avian pathogen worldwide, causing subclinical respiratory tract infection and infectious synovitis in chickens and turkeys. A temperature-sensitive (ts + ) live attenuated vaccine MS-H, derived from the Australian field strain 86079/7NS, is now widely used in many countries to control the disease induced by MS. Differentiation of MS-H vaccine from field strains is crucial for monitoring vaccination programs in commercial poultry. Comparison of genomic sequences of MS-H and its parent strain revealed an adenine deletion at nucleotide position 468 of the MS-H oppF-1 gene. This mutation was shown to be unique to MS-H in further comparative analyses of oppF-1 genes of MS-H re-isolates and field strains from Australia and other countries. Based on this single nucleotide, a combination of nested PCR and high-resolution melting (HRM) curve analysis was used to evaluate its potential for use in differentiation of MS-H from field strains. The mean genotype confidence percentages of 99.27 and 48.20 for MS-H and field strains, respectively, demonstrated the high discriminative power of the newly developed assay (oppF PCR-HRM). A set of 13 tracheal swab samples collected from MS-H vaccinated specific pathogen free birds and commercial chicken flocks infected with MS were tested using the oppF PCR-HRM test and results were totally consistent with those obtained using vlhA genotyping. The nested-PCR HRM method established in this study proved to be a rapid, simple and cost effective tool for discriminating the MS-H vaccine strain from Australian and international strains in pure cultures and on tracheal swabs. Copyright © 2017 Elsevier B.V. All rights reserved.

Guidance for Selecting Input Parameters in Modeling the Environmental Fate and Transport of Pesticides

EPA Pesticide Factsheets

Guidance to select and prepare input values for OPP's aquatic exposure models. Intended to improve the consistency in modeling the fate of pesticides in the environment and quality of OPP's aquatic risk assessments.

Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy.

PubMed

Yang, Jee Myung; Park, Sang Woo; Ji, Yong Sok; Kim, Jaeryung; Yoo, Chungkwon; Heo, Hwan

2017-04-20

To investigate postural effects on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with non-arteritic ischemic optic neuropathy (NAION). IOP and blood pressure (BP) were measured in 20 patients with unilateral NAION 10 min after changing to each of the following positions sequentially: sitting, supine, right lateral decubitus position (LDP), supine, left LDP, and supine. IOP was measured using a rebound tonometer and OPP was calculated using formulas based on mean BP. The dependent LDP (DLDP) was defined as the position when the eye of interest (affected or unaffected eye) was placed on the dependent side in the LDP. IOPs were significantly higher (P = 0.020) and OPPs were significantly lower (P = 0.041) in the affected eye compare with the unaffected eye, with the affected eye in DLDP. Compared with the mean IOP of the unaffected eyes, the mean IOP of the affected eyes increased significantly (+2.9 ± 4.4 versus +0.7 ± 3.1 mmHg, respectively; P = 0.003) and the mean OPP decreased significantly (-6.7 ± 9.4 versus -4.9 ± 8.0 mmHg, respectively; P = 0.022) after changing positions from supine to DLDP. In addition, changing position from supine to DLDP showed significantly larger absolute changes in IOP (4.13 ± 3.19 mmHg versus 2.51 ± 1.92 mmHg, respectively; P = 0.004) and OPP (9.86 ± 5.69 mmHg versus 7.50 ± 5.49 mmHg, respectively; P = 0.009) in the affected eye compared with the unaffected eye. In the affected eye, there was a significant positive correlation between absolute change in IOP and OPP when changing position from supine to DLDP (Rho = 0.512, P = 0.021). A postural change from supine to DLDP caused significant fluctuations in IOP and OPP of the affected eye, and may significantly increase IOP and decrease OPP. Posture-induced IOP changes may be a predisposing factor for NAION development.

76 FR 23351 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... Exchange would also be able to temporarily deactivate OPP from time to time on an intraday basis at its... intraday OPP deactivation due to volatility and any subsequent intraday reactivation by the Exchange...

77 FR 76588 - Request for Proposal Platform Pilot

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-28

...The Small Business Administration (SBA) is announcing a pilot where federal agencies will test a new request for proposal (RFP) platform (RFP-EZ) to streamline the process through which the government buys web design and related technology services from small businesses for acquisitions valued at or below the simplified acquisition threshold (SAT). RFP-EZ is one of five projects sponsored by the Office of Science and Technology Policy's Presidential Innovation Fellows Program, which leverages the ingenuity of leading problem solvers from across America together with federal innovators to tackle projects that aim to fuel job creation, save taxpayers money, and significantly improve how the federal government serves the American people. Under the RFP-EZ pilot, which will initially run from December 28, 2012 through May 1, 2013, agencies will identify individual procurements valued at or below the simplified acquisition threshold that can be set aside for small businesses to test a suite of functional tools for: (1) Simplifying the development of statements of work, (2) improving agency access to information about small businesses, (3) enabling small businesses to submit quotes, bids or proposals (collectively referred to as proposals) electronically in response to a solicitation posted on Federal Business Opportunities (FedBizOpps); (4) enhancing efficiencies for evaluating proposals, and (5) improving how information (including prices paid by federal agencies) is captured and stored. The pilot will be conducted in accordance with existing laws and regulations. Interested parties are encouraged to review and comment on the functionality of RFP-EZ, as described at www.sba.gov/rfpez and highlighted in this notice. Responses to this notice will be considered for possible refinements to the RFP-EZ platform during the pilot and as part of the evaluation of the benefits and costs of making RFP-EZ a permanent platform fully integrated with FedBizOpps, the System for Award Management and agency contract writing systems.

The potential of organic substrates based on mushroom substrate and straw to dissipate fungicides contained in effluents from the fruit-packaging industry - Is there a role for Pleurotus ostreatus?

PubMed

Karas, Panagiotis A; Makri, Sotirina; Papadopoulou, Evangelia S; Ehaliotis, Constantinos; Menkissoglu-Spiroudi, Urania; Karpouzas, Dimitrios G

2016-02-01

Citrus fruit-packaging plants (FPP) produce large wastewater volumes with high loads of fungicides like ortho-phenylphenol (OPP) and imazalil (IMZ). No methods are in place for the treatment of those effluents and biobeds appear as a viable alternative. We employed a column study to investigate the potential of spent mushroom substrate (SMS) of Pleurotus ostreatus, either alone or in mixture with straw and soil plus a mixture of straw /soil to retain and dissipate IMZ and OPP. The role of P. ostreatus on fungicides dissipation was also investigated by studying in parallel the performance of fresh mushroom substrate of P. ostreatus (FMS) and measuring lignolytic enzymatic activity in the leachates. All substrates effectively reduced the leaching of OPP and IMZ which corresponded to 0.014-1.1% and 0.120-0.420% of their initial amounts respectively. Mass balance analysis revealed that FMS and SMS/Straw/Soil (50/25/25 by vol) offered the most efficient removal of OPP and IMZ from wastewaters respectively. Regardless of the substrate, OPP was restricted in the top 0-20cm of the columns and was bioavailable (extractable with water), compared to IMZ which was less bioavailable (extractable with acetonitrile) but diffused at deeper layers (20-50, 50-80cm) in the SMS- and Straw/Soil-columns. PLFAs showed that fungal abundance was significantly lower in the top layer of all substrates from where the highest pesticide amounts were recovered suggesting an inhibitory effect of fungicides on total fungi in the substrates tested. Our data suggest that biobeds packed with SMS-rich substrates could ensure the efficient removal of IMZ and OPP from wastewaters of citrus FPP. Copyright © 2015 Elsevier Inc. All rights reserved.

Strengthening Health Systems of Developing Countries: Inclusion of Surgery in Universal Health Coverage.

PubMed

Okoroh, Juliet S; Chia, Victoria; Oliver, Emily A; Dharmawardene, Marisa; Riviello, Robert

2015-08-01

Universal health coverage (UHC) has its roots in the Universal Declaration of Human Rights and has recently gained momentum. Out-of-pocket payments (OPP) remain a significant barrier to care. There is an increasing global prevalence of non-communicable diseases, many of which are surgically treatable. We sought to provide a comparative analysis of the inclusion of surgical care in operating plans for UHC in low- and middle-income countries (LMIC). We systematically searched PubMed and Google Scholar using pre-defined criteria for articles published in English, Spanish, or French between January 1991 and November 2013. Keywords included "insurance," "OPP," "surgery," "trauma," "cancer," and "congenital anomalies." World Health Organization (WHO), World Bank, and Joint Learning Network for UHC websites were searched for supporting documents. Ministries of Health were contacted to provide further information on the inclusion of surgery. We found 696 articles and selected 265 for full-text review based on our criteria. Some countries enumerated surgical conditions in detail (India, 947 conditions). Other countries mentioned surgery broadly. Obstetric care was most commonly covered (19 countries). Solid organ transplantation was least covered. Cancer care was mentioned broadly, often without specifying the therapeutic modality. No countries were identified where hospitals are required to provide emergency care regardless of insurance coverage. OPP varied greatly between countries. Eighty percent of countries had OPP of 60% or more, making these services, even if partially covered, largely inaccessible. While OPP, delivery, and utilization continue to represent challenges to health care access in many LMICs, the inclusion of surgery in many UHC policies sets an important precedent in addressing a growing global prevalence of surgically treatable conditions. Barriers to access, including inequalities in financial protection in the form of high OPP, remain a fundamental challenge to providing surgical care in LMICs.

Funding Opportunity Announcement: The Economics of School Integrated Pest Management (IPM) (EPA-OPP-2015-007)

EPA Pesticide Factsheets

EPA/OPP is soliciting proposals from eligible parties for a cooperative agreement to provide financial assistance to an eligible organization to research and analyze the economics of implementing IPM in public and tribal schools in the U.S.

Guidance for Considering and Using Open Literature Toxicity Studies to Support Human Health Risk Assessment

EPA Pesticide Factsheets

This guidance was developed to assist OPP scientists and is intended for use in OPP’s risk assessments. It is intended to ensure consistent consideration, use, and documentation of information in the open literature by OPP scientists and risk assessors.

78 FR 29132 - Environmental Management Resources, Inc.; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... Business Information (CBI) by the submitter, will be transferred to Environmental Management Resources, Inc. Environmental Management Resources, Inc. has been awarded a contract to perform work for OPP, and access to this... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0536; FRL-9385-5] Environmental Management...

Disability management practices in education, hotel/motel, and health care workplaces.

PubMed

Williams, Renee M; Westmorland, Muriel G; Shannon, Harry S; Rasheed, Farah; Amick, Benjamin C

2005-03-01

The high costs and the impact of work disability have become a growing concern for workplaces. As a result, workplace disability management approaches have been developed to lower disability costs, protect the employability of workers, and promote early return to work. A stratified random sample of 455 employers in education (n = 157), hotel/motel (n = 110), and health care (n = 188) sectors who completed a mailed Organizational Policies and Practices (OPP) questionnaire is reported. The OPP questionnaire asked questions about eight workplace disability management practices. The article examined the multi-dimensionality, internal consistency, and discriminant validity of the OPP and compares disability management practices across the three sectors. The OPP questionnaire showed good internal consistency (Cronbach's alpha = 0.95) and discriminant validity. A one-way analysis of variance (ANOVA) for each of the eight subscales demonstrated that there were statistically significant differences between the sectors in ergonomic practices (F (2,452) = 15.8, P < 0.001), disability case management (F (2,452) = 4.6, P < 0.01), return to work (F (2,452) = 10.3, P < 0.001), and people-oriented culture (F (2,452) = 4.5, P < 0.01). On examining disability management practices in education, hotel/motel, and health care sectors, the OPP seems to be a promising instrument that can be used to assess and monitor how employers are managing disability.

Medicare and Medicaid programs: hospital outpatient prospective payment; ambulatory surgical center payment; hospital value-based purchasing program; physician self-referral; and patient notification requirements in provider agreements. Final rule with comment period.

PubMed

2011-11-30

This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) for CY 2012 to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare hospital outpatient services paid under the OPPS. In addition, this final rule with comment period updates the revised Medicare ambulatory surgical center (ASC) payment system to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this final rule with comment period, we set forth the relative payment weights and payment amounts for services furnished in ASCs, specific HCPCS codes to which these changes apply, and other ratesetting information for the CY 2012 ASC payment system. We are revising the requirements for the Hospital Outpatient Quality Reporting (OQR) Program, adding new requirements for ASC Quality Reporting System, and making additional changes to provisions of the Hospital Inpatient Value-Based Purchasing (VBP) Program. We also are allowing eligible hospitals and CAHs participating in the Medicare Electronic Health Record (EHR) Incentive Program to meet the clinical quality measure reporting requirement of the EHR Incentive Program for payment year 2012 by participating in the 2012 Medicare EHR Incentive Program Electronic Reporting Pilot. Finally, we are making changes to the rules governing the whole hospital and rural provider exceptions to the physician self-referral prohibition for expansion of facility capacity and changes to provider agreement regulations on patient notification requirements.

77 FR 59611 - Notice of Receipt of Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-28

... Symbol: 85004-RN. Docket ID Number: EPA-HQ-OPP-2012- 0609. Applicant: Pasteuria Bioscience, Inc., 12085 Research Dr., Suite 185, Alachua, FL 32615. Active ingredient: Nematicide with Pasteuria spp. (Hoplolaimus... Symbol: 85004-RR. Docket ID Number: EPA-HQ-OPP-2012- 0609. Applicant: Pasteuria Bioscience, Inc., 12085...

Comparison of Weight Training and Calisthentic Exercise Programs in Developing Strength and Muscular Endurance in United States Army Recruits.

DTIC Science & Technology

1983-05-01

Calisth nic Exercise Programs in "eveloping Strength Final *eportllApr83 and Muscular Endurance in United States S. PERFORMING ORG. NEPORT NUMBER Army...HQDAMILPERCEN DAPC-OPP-E 200Stovall Street Alexandria,VA 22332 Final Report 11 April 1983 Approved for public release A thesis submitted to The...can be maintained with as little as one workout per week, e) the strength of any muscle is a result of the quantity and quality of muscle tissue, f

76 FR 42169 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-18

...This proposed rule would revise the Medicare hospital outpatient prospective payment system (OPPS) to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this proposed rule, we describe the proposed changes to the amounts and factors used to determine the payment rates for Medicare hospital outpatient services paid under the OPPS. These proposed changes would be applicable to services furnished on or after January 1, 2012. In addition, this proposed rule would update the revised Medicare ambulatory surgical center (ASC) payment system to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this proposed rule, we set forth the proposed relative payment weights and payment amounts for services furnished in ASCs, specific HCPCS codes to which these proposed changes would apply, and other proposed ratesetting information for the CY 2012 ASC payment system. These proposed changes would be applicable to services furnished on or after January 1, 2012. We are proposing to revise the requirements for the Hospital Outpatient Quality Reporting (IQR) Program, add new requirements for ASC Quality Reporting System, and make additional changes to provisions of the Hospital Inpatient Value-Based Purchasing (VBP) Program. We also are proposing to allow eligible hospitals and CAHs participating in the Medicare Electronic Health Record (EHR) Incentive Program to meet the clinical quality measure reporting requirement of the EHR Incentive Program for payment year 2012 by participating in the 2012 Medicare EHR Incentive Program Electronic Reporting Pilot. In addition, we are proposing to make changes to the rules governing the whole hospital and rural provider exceptions to the physician self-referral prohibition for expansion of facility capacity and changes to provider agreement regulations on patient notification requirements.

76 FR 34978 - Petition Supplement Requesting Cancellation of Propoxur Pet Collar Uses; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... non-dietary oral exposure pathway presented in the Revised N-methyl Carbamate (NMC) Cumulative Risk... Cumulative Risk Assessment docket EPA-HQ- OPP-2007-0935; 2. A petition supplement, dated April 23, 2009... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0207; FRL-8875-1] Petition Supplement Requesting...

77 FR 38043 - TRICARE; Revised Guideline for Determining the Outpatient Prospective Payment System (OPPS...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... within these private pay norms was chosen as a method to more equitably meet DoD's objectives in making...) Amount AGENCY: Department of Defense (DoD). ACTION: Notice of revised guideline for determining TRICARE's... the methodology to calculate TRICARE's OPPS General TMCPA amount for qualifying hospitals. DATES: The...

76 FR 57034 - Pesticide Products; Receipt of Applications To Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

...-OPP-2009-0677. Company Name and Address: Arysta LifeScience, North America LLC, 15401 Weston Parkway...: 66330-45 and 66330-46. Docket Number: EPA- HQ-OPP-2011-0641. Company Name and Address: Arysta LifeScience North America LLC, 15401 Weston Parkway, Suite 150, Cary, NC 27513. Active Ingredient...

76 FR 59909 - Amisulbrom; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

....regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One..., identified by docket ID number EPA-HQ-OPP-2010-0186, by one of the following methods: Federal eRulemaking...), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA...

76 FR 82152 - Cyhalofop-butyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... original long-term studies were approaching a maximum tolerated dose. In addition, there were no positive....regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One..., identified by docket ID number EPA-HQ-OPP-2011-0283, by one of the following methods: Federal eRulemaking...

78 FR 44948 - Notice of Receipt of Requests for Amendments To Delete Uses in Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0480; FRL-9392-2] Notice of Receipt of Requests for Amendments To Delete Uses in Certain Pesticide Registrations AGENCY: Environmental Protection... following methods: Mail: OPP Docket, Environmental Protection Agency Docket Center (EPA/DC), (28221T), 1200...

77 FR 31356 - Pesticide Products; Receipt of Applications To Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... Number: EPA-HQ-OPP-2012- 0241. Company name and address: Bayer CropScience LP, 2 T. W. Alexander Drive.... Registration Number: 264-825. Docket Number: EPA-HQ-OPP-2012- 0325. Company name and address: Bayer CropScience... pesticide manufacturer. Potentially affected entities may include, but are not limited to: Crop production...

Organophosphate Pesticide Residues in Drinking Water from Artesian Wells and Health Risk Assessment of Agricultural Communities, Thailand

PubMed Central

Jaipieam, S.; Visuthismajarn, P.; Sutheravut, P.; Siriwong, W.; Thoumsang, S.; Borjan, M.; Robson, M.

2010-01-01

Organophosphate pesticide (OPPs) concentrations in artesian wells located in Thai agricultural and non-agricultural communities were studied during both wet and dry seasons. A total of 100 water samples were collected and subjects were asked to complete a survey. Gas chromatography flame photometric detector was used for OPP analysis. The average OPP concentration in the agricultural communities (0.085 and 0.418 µg/l in dry and wet season) was higher than in the non-agricultural communities (0.004 µg/l in both seasons). Ingestion of OPPs in contaminated water in the agricultural communities were estimated to be 0.187 and 0.919 µg/day during the dry and wet seasons, respectively, and 0.008 µg/day during both seasons in the non-agricultural communities. Agricultural communities were exposed to pesticide residues under the oral chronic reference dose. This study suggests that people in agricultural communities may be exposed to significantly greater levels of pesticides than non-agricultural populations during the dry and wet seasons (p < .001, .001). PMID:20485459

Organophosphate Pesticide Residues in Drinking Water from Artesian Wells and Health Risk Assessment of Agricultural Communities, Thailand.

PubMed

Jaipieam, S; Visuthismajarn, P; Sutheravut, P; Siriwong, W; Thoumsang, S; Borjan, M; Robson, M

2009-01-01

Organophosphate pesticide (OPPs) concentrations in artesian wells located in Thai agricultural and non-agricultural communities were studied during both wet and dry seasons. A total of 100 water samples were collected and subjects were asked to complete a survey. Gas chromatography flame photometric detector was used for OPP analysis. The average OPP concentration in the agricultural communities (0.085 and 0.418 microg/l in dry and wet season) was higher than in the non-agricultural communities (0.004 microg/l in both seasons). Ingestion of OPPs in contaminated water in the agricultural communities were estimated to be 0.187 and 0.919 microg/day during the dry and wet seasons, respectively, and 0.008 microg/day during both seasons in the non-agricultural communities. Agricultural communities were exposed to pesticide residues under the oral chronic reference dose. This study suggests that people in agricultural communities may be exposed to significantly greater levels of pesticides than non-agricultural populations during the dry and wet seasons (p < .001, .001).

The development of a cryogenic over-pressure pump

NASA Astrophysics Data System (ADS)

Alvarez, M.; Cease, H.; Flaugher, B.; Flores, R.; Garcia, J.; Lathrop, A.; Ruiz, F.

2014-01-01

A cryogenic over-pressure pump (OPP) was tested in the prototype telescope liquid nitrogen (LN2) cooling system for the Dark Energy Survey (DES) Project. This OPP consists of a process cylinder (PC), gas generator, and solenoid operated valves (SOVs). It is a positive displacement pump that provided intermittent liquid nitrogen (LN2) flow to an array of charge couple devices (CCDs) for the prototype Dark Energy Camera (DECam). In theory, a heater submerged in liquid would generate the drive gas in a closed loop cooling system. The drive gas would be injected into the PC to displace that liquid volume. However, due to limitations of the prototype closed loop nitrogen system (CCD cooling system) for DECam, a quasiclosed-loop nitrogen system was created. During the test of the OPP, the CCD array was cooled to its designed set point temperature of 173K. It was maintained at that temperature via electrical heaters. The performance of the OPP was captured in pressure, temperature, and flow rate in the CCD LN2 cooling system at Fermi National Accelerator Laboratory (FNAL).

The economic burden of chronic disease care faced by households in Ukraine: a cross-sectional matching study of angina patients

PubMed Central

2013-01-01

Introduction Non-communicable diseases (NCDs) are the leading cause of death and disability worldwide, and their prevalence in lower- and middle-income countries (LMIC) is on the rise. The burden of chronic health expenditure born by patient households in these countries may be very high, particularly where out-of-pocket payments for health care are common. One such country where out-of-pocket payments are especially high is Ukraine. The financial impact of NCDs on households in this country has not been researched. Methods We set out to explore the burden of NCD care in Ukraine with a study of angina patients. Using data from the Ukraine World Health Survey of 2003 we employed the novel Coarsened Exact Matching approach to estimate the difference in out-of-pocket payment (OPP) for health care between households with a stable angina pectoris (a chronic form of IHD) patient and those without. The likelihood of engaging in catastrophic spending and using various distress financing mechanisms (e.g. sale of assets, borrowing) among angina households compared with non-angina households was also explored. Results Among angina patient households (n = 203), OPP occupied an average of 32% of household effective income. After matching, angina households experienced significantly higher monthly per capita OPP for health care (B = $2.84) and medicines (B = $2.94), but were not at significantly higher odds of engaging in catastrophic spending. Odds of engaging in ‘sale of assets’ (OR = 2.71) and ‘borrowing’ (OR = 1.68) to finance OPP were significantly higher among angina households. Conclusions The cost of chronic care in Ukraine places a burden on individual patient households. Households of angina patients are more likely to engage in distress financing to cover the cost of treatment, and a high proportion of patients do not acquire prescribed medicines because they cannot afford them. This warrants further research on the burden of NCD care in other LMIC, especially where OPP for health care is common. Health policies aimed at reducing OPP for health care, and especially medicines, would lessen the high health and financial burden of chronic care. Further research is also needed on the long-term impact of borrowing or sale of assets to finance OPP on patient households. PMID:23718769

12om Limited Objective Experiment #2: Final Results Summary and Recommendations

DTIC Science & Technology

2014-03-31

Acronym Definition ARP CD CF CFD CG CIM COA CONOPS CSE Dev DFATD DP DRDC FGS Gov HREC IDP KR LOE LOC MA MARS NASA TLX NGO OP OPP Ops ROC SA...weight Ratings (OPP Support) Ratings (IP) Ratings (CU) Ratings (CS) Ratings (Usability) Ratings (Training T/E) Ratings (Use T/E) NASA TLX Mental demand

77 FR 791 - Kasugamycin; Receipt of Application for Emergency Exemption for Use on Apples in Michigan...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-1016; FRL-9331-5] Kasugamycin; Receipt of... treat up to 10,000 acres of apples to control fire blight. The applicant proposes the use of a new...-OPP-2011-1016, by one of the following methods: Federal eRulemaking Portal: http://www.regulations.gov...

Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; Organ Procurement Organization Reporting and Communication; Transplant Outcome Measures and Documentation Requirements; Electronic Health Record (EHR) Incentive Programs; Payment to Nonexcepted Off-Campus Provider-Based Department of a Hospital; Hospital Value-Based Purchasing (VBP) Program; Establishment of Payment Rates Under the Medicare Physician Fee Schedule for Nonexcepted Items and Services Furnished by an Off-Campus Provider-Based Department of a Hospital. Final rule with comment period and interim final rule with comment period.

PubMed

2016-11-14

This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2017 to implement applicable statutory requirements and changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system. In addition, this final rule with comment period updates and refines the requirements for the Hospital Outpatient Quality Reporting (OQR) Program and the ASC Quality Reporting (ASCQR) Program. Further, in this final rule with comment period, we are making changes to tolerance thresholds for clinical outcomes for solid organ transplant programs; to Organ Procurement Organizations (OPOs) definitions, outcome measures, and organ transport documentation; and to the Medicare and Medicaid Electronic Health Record Incentive Programs. We also are removing the HCAHPS Pain Management dimension from the Hospital Value-Based Purchasing (VBP) Program. In addition, we are implementing section 603 of the Bipartisan Budget Act of 2015 relating to payment for certain items and services furnished by certain off-campus provider-based departments of a provider. In this document, we also are issuing an interim final rule with comment period to establish the Medicare Physician Fee Schedule payment rates for the nonexcepted items and services billed by a nonexcepted off-campus provider-based department of a hospital in accordance with the provisions of section 603.

Ocular Perfusion Pressure and Pulsatile Ocular Blood Flow in Normal and Systemic Hypertensive Patients.

PubMed

Kanadani, Fabio N; Figueiredo, Carlos R; Miranda, Rafaela Morais; Cunha, Patricia Lt; M Kanadani, Tereza Cristina; Dorairaj, Syril

2015-01-01

Glaucomatous neuropathy can be a consequence of insufficient blood supply, increase in intraocular pressure (IOP), or other risk factors that diminish the ocular blood flow. To determine the ocular perfusion pressure (OPP) in normal and systemic hypertensive patients. One hundred and twenty-one patients were enrolled in this prospective and comparative study and underwent a complete ophthalmologic examination including slit lamp examination, Goldmann applanation tonometry, stereoscopic fundus examination, and pulsatile ocular blood flow (POBF) measurements. The OPP was calculated as being the medium systemic arterial pressure (MAP) less the IOP. Only right eye values were considered for calculations using Student's t-test. The mean age of the patients was 57.5 years (36-78), and 68.5% were women. There was a statistically significant difference in the OPP of the normal and systemic hypertensive patients (p < 0.05). The difference in the OPP between these groups varied between 8.84 and 17.9 mm Hg. The results of this study suggest that although the systemic hypertensive patients have a higher OPP in comparison to normal patients, this increase does not mean that they also have a higher OBF (as measured by POBF tonograph). This may be caused by chronic changes in the vascular network and in the blood hemodynamics in patients with systemic hypertension. How to cite this article: Kanadani FN, Figueiredo CR, Miranda RM, Cunha PLT, Kanadani TCM, Dorairaj S. Ocular Perfusion Pressure and Pulsatile Ocular Blood Flow in Normal and Systemic Hypertensive Patients. J Curr Glaucoma Pract 2015;9(1):16-19.

[Magnetic solid phase extraction combined with gas chromatography-flame photometric detection for the determination of organophosphorus pesticides in juice samples].

PubMed

Huang, Qian; He, Man; Chen, Beibei; Hu, Bin

2014-10-01

A novel method for the determination of organophosphorous pesticides (OPPs) in fresh juice samples was developed. Fe3O4 @ P (St-co-MAA) magnetic microparticles were synthesized and modified with styrene (St) and methacrylic acid (MAA) by coating St and MAA on magnetic particles and characterized by a series of techniques. The results indicated that Fe3 O4 magnetic nanoparticles (MNPs) have been successfully modified with St and MAA. Based on the prepared FeO4 @ P (St-co-MAA) magnetic microparticles, a novel method of magnetic solid phase extraction (MSPE)-gas chromatography (GC)-flame photometric detection (FPD) was developed for the determination of OPPs. The extraction/desorption conditions of MSPE were optimized, and the analytical performance was evaluated under the optimal conditions. The limits of detection (LODs, S/N = 3) for target OPPs were in the range of 0.013-0.305 μg/L with the RSDs (n = 7) ranging from 3.1% to 8.8%. The enrichment factors varied from 406 to 951. The linear ranges were over three orders of magnitudes (R2 > 0.99) and the reproducibilities were 7.4%-14.5% (n = 5). Finally, the proposed MSPE-GC-FPD method was successfully applied to the analysis of the five OPPs in fresh tomato and strawberry juice samples, with the recoveries of target OPPs in the range of 85.4%-118.9% for the spiked samples. The proposed MSPE-GC-FPD method is featured with low cost, fast separation and high enrichment factor.

Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure.

PubMed

Polska, Elzbieta; Simader, Christian; Weigert, Günter; Doelemeyer, Arno; Kolodjaschna, Julia; Scharmann, Ole; Schmetterer, Leopold

2007-08-01

To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). There were two study days in an open design. On the first day, OPP was varied by elevating IOP during a squatting-induced increase in MAP (28 subjects). On the second day, only the IOP was increased (17 subjects). IOP was raised in stepwise increments by using the suction cup Subfoveal ChBF (laser Doppler flowmetry), MAP, and IOP were assessed, and OPP was calculated as (2/3)(MAP - IOP). For correlation analysis, data from all subjects were pooled according to IOP and MAP, and correlation analyses were performed. When data from study day 1 were grouped according to IOP, no correlation was observed between ChBF and MAP; but ChBFs were lower, the higher the IOP (P < 0.001). When data were grouped according to MAP, a significant correlation was found between ChBF and IOP (P < 0.001), but correlations were independent of MAP. When data of study day 2 were pooled according to IOP, a correlation between ChBF and OPP was seen only at IOP > 40 mm Hg (P < 0.05). The data confirm previously published observations that the choroid shows some autoregulatory capacity during changes in OPP. In addition, the data indicate that the choroid regulates its blood flow better during exercise-induced changes in MAP than during an experimental increase in IOP.

Transport of beta-casein-derived peptides by the oligopeptide transport system is a crucial step in the proteolytic pathway of Lactococcus lactis.

PubMed

Kunji, E R; Hagting, A; De Vries, C J; Juillard, V; Haandrikman, A J; Poolman, B; Konings, W N

1995-01-27

In the proteolytic pathway of Lactococcus lactis, milk proteins (caseins) are hydrolyzed extracellularly to oligopeptides by the proteinase (PrtP). The fate of these peptides, i.e. extracellular hydrolysis followed by amino acid uptake or transport followed by intracellular hydrolysis, has been addressed. Mutants have been constructed that lack a functional di-tripeptide transport system (DtpT) and/or oligopeptide transport system (Opp) but do express the P1-type proteinase (specific for hydrolysis of beta- and to a lesser extent kappa-casein). The wild type strain and the DtpT- mutant accumulate all beta-casein-derived amino acids in the presence of beta-casein as protein substrate and glucose as a source of metabolic energy. The amino acids are not accumulated significantly inside the cells by the Opp- and DtpT- Opp- mutants. When cells are incubated with a mixture of amino acids mimicking the composition of beta-casein, the amino acids are taken up to the same extent in all four strains. Analysis of the extracellular peptide fraction, formed by the action of PrtP on beta-casein, indicates that distinct peptides disappear only when the cells express an active Opp system. These and other experiments indicate that (i) oligopeptide transport is essential for the accumulation of all beta-casein-derived amino acids, (ii) the activity of the Opp system is sufficiently high to support high growth rates on beta-casein provided leucine and histidine are present as free amino acids, and (iii) extracellular peptidase activity is not present in L. lactis.

Occurrence, composition and ecological restoration of organic pollutants in water environment of South Canal, China

NASA Astrophysics Data System (ADS)

Wang, Y. Z.; Lin, C.; Zhou, X. S.; Zhang, Y.; Han, C. G.

2017-08-01

Ecological restoration of polluted river water was carried out in South Canal by adding microbial water purifying agents and biological compound enzymes. The objective of present study was to investigate the ecological restoration effect of organic pollutants by this efficient immobilized microbial technologies, analysis the occurrence and composition of organic pollutants including fifteen persistent organochlorine pesticides (OCPs), seventeen polycyclic aromatic hydrocarbons (PAHs) and eighteen organophosphorus pesticides (OPPs) both in natural water environment and ecological restoration area of South Canal, China. Results showed that the total concentrations of OCPs ranged from 1.11 to 1.78 ng·L-1, PAHs from 52.76 to 60.28 ng·L-1, and OPPs from 6.51 to 17.50 ng·L-1. Microbial water purifying agents and biological compound enzymes essentially had no effects on biological degradation of OCPs and PAHs in the river, but could remove OPPs with degradation rates ranging from 19.6% to 62.8% (35.2% in average). Degradation mechanisms of microbial water purifying agents and biological compound enzymes on OCPs, PAHs and OPPs remained to be further studied. This technology has a certain value in practical ecological restoration of organic pollutants in rivers and lakes.

Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children.

PubMed

Ren, Dabin; Almudevar, Anthony L; Murphy, Timothy F; Lafontaine, Eric R; Campagnari, Anthony A; Luke-Marshall, Nicole; Casey, Janet R; Pichichero, Michael E

2015-10-26

There is no licensed vaccine for Moraxella catarrhalis (Mcat), which is a prominent bacterium causing acute otitis media (AOM) in children and lower respiratory tract infections in adults. Nasopharyngeal (NP) colonization caused by respiratory bacteria results in natural immunization of the host. To identify Mcat antigens as vaccine candidates, we evaluated the development of naturally induced antibodies to 5 Mcat surface proteins in children 6-30 months of age during Mcat NP colonization and AOM. Human serum IgG against the recombinant Mcat proteins, outer membrane protein (OMP) CD, oligopeptide permease (Opp)A, hemagglutinin (Hag), Moraxella surface protein (Msp)22, and PilA clade 2 (PilA2) was quantitated by using an ELISA assay. There were 223 Mcat NP colonization episodes documented in 111 (60%) of 184 children in the study. Thirty five Mcat AOM episodes occurred in 30 (16%) of 184 children. All 5 Mcat candidate vaccine antigens evaluated stimulated a significant rise in serum IgG levles over time from 6 to 36 months of age (P<0.001), with a rank order as follows: Msp22=OppA>OMP CD=Hag=PilA2. Children with no detectable Mcat NP colonization showed a higher serum IgG level against OppA, Hag, and Msp22 compared to those with Mcat NP colonization (P<0.05). Individual data showed that some children responded to AOM with an antibody increase to one or more of the studied Mcat proteins but some children failed to respond. Serum antibody to Mcat candidate vaccine proteins OMP CD, OppA, Msp22, Hag, and PilA2 increased with age in naturally immunized children age 6-30 months following Mcat NP colonization and AOM. High antibody levels against OppA, Msp22, and Hag correlated with reduced carriage. The results support further investigation of these vaccine candidates in protecting against Mcat colonization and infection. Copyright © 2015 Elsevier Ltd. All rights reserved.

Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children

PubMed Central

Ren, Dabin; Almudevar, Anthony L.; Murphy, Timothy F.; Lafontaine, Eric R.; Campagnari, Anthony A.; Luke-Marshall, Nicole; Casey, Janet R.; Pichichero, Michael E.

2015-01-01

Background There is no licensed vaccine for Moraxella catarrhalis (Mcat), which is a prominent bacterium causing acute otitis media (AOM) in children and lower respiratory tract infections in adults. Nasopharyngeal (NP) colonization caused by respiratory bacteria results in natural immunization of the host. To identify Mcat antigens as vaccine candidates, we evaluated the development of naturally induced antibodies to 5 Mcat surface proteins in children 6–30 months of age during Mcat NP colonization and AOM. Methods Human serum IgG against the recombinant Mcat proteins, outer membrane protein (OMP) CD, oligopeptide permease (Opp)A, hemagglutinin (Hag), Moraxella surface protein (Msp)22, and PilA clade 2 (PilA2) was quantitated by using an ELISA assay. Results There were 223 Mcat NP colonization episodes documented in 111 (60%) of 184 children in the study. Thirty five Mcat AOM episodes occurred in 30 (16%) of 184 children. All 5 Mcat candidate vaccine antigens evaluated stimulated a significant rise in serum IgG levles over time from 6 to 36 months of age (P < 0.001), with a rank order as follows: Msp22 = OppA > OMP CD = Hag = PilA2. Children with no detectable Mcat NP colonization showed a higher serum IgG level against OppA, Hag, and Msp22 compared to those with Mcat NP colonization (P < 0.05). Individual data showed that some children responded to AOM with an antibody increase to one or more of the studied Mcat proteins but some children failed to respond. Conclusions Serum antibody to Mcat candidate vaccine proteins OMP CD, OppA, Msp22, Hag, and PilA2 increased with age in naturally immunized children age 6–30 months following Mcat NP colonization and AOM. High antibody levels against OppA, Msp22, and Hag correlated with reduced carriage. The results support further investigation of these vaccine candidates in protecting against Mcat colonization and infection. PMID:26392013

Developing osteopathic competencies in geriatrics for medical students.

PubMed

Noll, Donald R; Channell, Millicent King; Basehore, Pamela M; Pomerantz, Sherry C; Ciesielski, Janice; Eigbe, Patrick Arekhandia; Chopra, Anita

2013-04-01

Minimum core competencies for allopathic medical students in the specialty area of geriatrics have been developed, comprising 26 competencies divided into 8 topical domains. These competencies are appropriate for osteopathic medical students, but they do not include competencies relating to osteopathic principles and practice (OPP) in geriatrics. There remains a need within the osteopathic profession to develop specialty-specific competencies specific to OPP. To develop more specific and comprehensive minimum competencies in OPP for osteopathic medical students in the field of geriatric medicine. The Delphi technique (a structured communication technique that uses a panel of experts to reach consensus) was adapted to generate new core competencies relating to OPP. Osteopathic geriatricians and members of the Educational Council on Osteopathic Principles (ECOP) of the American Association of Colleges of Osteopathic Medicine participated in a breakout session and 2 rounds of surveys. Proposed competencies with 80% of the participants ranking it as "very important and should be added as a competency" were retained. Participants were also asked if they agreed that competencies in OPP should include specific types of osteopathic manipulative treatment techniques for the elderly. Responses were received from 26 osteopathic physician experts: 17 ECOP members and 9 geriatricians. Fourteen proposed competencies were developed: 7 related to the existing topic domains, and 7 were placed into a new domain of osteopathic manipulative medicine (OMM). Six proposed competencies were retained, all of which were in the new OMM domain. These competencies related to using OMM for gait and balance assessment, knowing adverse events and contraindications of OMM, using OMM for pain relief and end-of-life care, using OMM in the hospital and nursing home setting, adapting OMM to fit an elderly individual, and using OMM to address limited range of motion and ability to perform activities of daily living. Thirteen of 22 participants (59%) agreed that OPP competencies should include specific osteopathic manipulative treatment techniques. The Delphi consensus building process was used to create 6 new minimum competencies in OMM for osteopathic medical students for the specialty area of geriatrics. Using data from this consensus, medical schools, residencies, and fellowships can create standards and expectations for osteopathic physicians regarding the best care of geriatric patients.

The Dawn of Transparency: Insights from the Physician Payment Sunshine Act in Plastic Surgery

PubMed Central

Ahmed, Rizwan; Lopez, Joseph; Bae, Sunjae; Massie, Allan B.; Chow, Eric K.; Chopra, Karan; Orandi, Babak J.; Lonze, Bonnie E.; May, James W; Sacks, Justin M.; Segev, Dorry L.

2016-01-01

Background The Physician Payments Sunshine Act (PSSA) is a government initiative that requires all biomedical companies to publicly disclose payments to physicians through the Open Payments Program (OPP). The goal of this study was to utilize the OPP database and evaluate all non-research related financial transactions between plastic surgeons and biomedical companies. Methods Using the first wave of OPP data published on September 30, 2014, we studied the national distribution of industry payments made to plastic surgeons during a five month period. We explored whether a plastic surgeon’s scientific productivity, (as determined by their h-index), practice setting (private versus academic), geographic location, and subspecialty were associated with payment amount. Results Plastic surgeons (N=4,195) received a total of $5,278,613. The median (IQR) payment to a plastic surgeon was $115($35–298); mean $1,258. The largest payment to an individual was $341,384. The largest payment category was non-CEP speaker fees ($1,709,930) followed by consulting fees ($1,403,770). Plastic surgeons in private practice received higher payments per surgeon compared to surgeons in academic practice (median [IQR] $165[$81 – $441] vs. median [IQR] $112 [$33–$291], rank-sum p<0.001). Among academic plastic surgeons, a higher h-index was associated with 77% greater chance of receiving at least $1000 in total payments (RR/10 unit h-index increase=1.47 1.77 2.11, p<0.001). This association was not seen among plastic surgeons in private practice (RR=0.89 1.09 1.32, p<0.4). Conclusion Plastic surgeons in private practice receive higher payments from industry. Among academic plastic surgeons, higher payments were associated with higher h-indices. PMID:28182596

Identification of OppA2 Linear Epitopes as Serodiagnostic Markers for Lyme Disease

PubMed Central

Signorino, Giacomo; Arnaboldi, Paul M.; Petzke, Mary M.

2014-01-01

Laboratory diagnosis of Lyme disease is based on the serological detection of antibodies against the etiologic agent Borrelia burgdorferi. Current diagnostics are insensitive at detecting early infection, when treatment is most effective. This deficiency results from the limited number of B. burgdorferi antigens expressed in early infection and the use of an insensitive two-tier paradigm, put in place to deal with insufficient specificity associated with the use of whole-protein antigens and/or bacterial lysates as serodiagnostic targets. Whole-protein antigens contain epitopes that are unique to B. burgdorferi as well as cross-reactive epitopes found in other bacteria. One method for overcoming the limitations imposed by cross-reactive epitopes is the use of short peptides containing epitopes unique to B. burgdorferi as antigen targets. This eliminates nonspecific epitopes. Using overlapping peptide libraries, we performed epitope mapping of linear epitopes in oligopeptide permease A2 (OppA2), a member of the oligopeptide permease (Opp) family of peptide transporters, expressed during early B. burgdorferi infection. We identified 9 epitopes, synthesized peptides containing these epitopes, and screened those using panels of blood from patients with early Lyme disease, rheumatoid arthritis (RA), or syphilis or from healthy individuals. Two of the peptides, OppA2 (191-225) (amino acids comprising the peptide are shown in parentheses) and OppA2 (381-400), are highly conserved among the three major pathogenic Borrelia species responsible for most Lyme disease cases in North America and Europe. They detected antibodies in Lyme disease patient sera with sufficient sensitivity and specificity to indicate that they could have value in a serological assay for Lyme disease. PMID:24623628

A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning.

PubMed

von der Wellen, Jens; Winterhalter, Peter; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald

2018-08-01

Exposure to toxic organophosphorus pesticides (OPP) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks. Therefore, reliable verification procedures for OPP-intoxications are required for forensic, toxicological and clinical reasons. We developed and optimized a toolbox of methods to detect adducts of human serum albumin (HSA) with OPP considered as long-term biomarkers. Human serum was incubated with diethyl-oxono and diethyl-thiono pesticides for adduct formation used as reference. Afterwards serum was subjected to proteolysis using three proteases separately thus yielding phosphorylated tyrosine residues (Y*) detected as single amino acid (pronase), as hexadecapeptide LVRY* 411 TKKVPQVSTPTL (pepsin) and as the tripeptide Y* 411 TK (trypsin), respectively. Adducts were analyzed via microbore liquid chromatography coupled to electrospray ionization (μLC-ESI) and tandem-high-resolution mass spectrometry (MS/HR MS). Using paraoxon-ethyl as model OPP for adduct formation, methods were optimized with respect to MS/HR MS-parameters, protease concentrations and incubation time for proteolysis. HSA-adducts were found to be stable in serum in vitro at +37 °C and -30 °C for at least 27 days and resulting biomarkers were stable in the autosampler at 15 °C for at least 24 h. Limits of identification of adducts varied between 0.25 μM and 4.0 μM with respect to the corresponding pesticide concentrations in serum. Applicability of the methods was proven by successful detection of the adducts in samples of OPP-poisoned patients thus demonstrating the methods as a reliable toolbox for forensic and toxicological analysis. Copyright © 2018 Elsevier B.V. All rights reserved.

Selectivity improvement of positive photoionization ion mobility spectrometry for rapid detection of organophosphorus pesticides by switching dopant concentration.

PubMed

Zhou, Qinghua; Li, Jia; Wang, Bin; Wang, Shuang; Li, Haiyang; Chen, Jinyuan

2018-01-01

Ion mobility spectrometry (IMS) opened a potential avenue for the rapid detection of organophosphorus pesticides (OPPs), though an improved selectivity of stand-alone IMS was still in high demand. In this study, a stand-alone positive photoionization ion mobility spectrometry (PP-IMS) apparatus was constructed for the rapid detection of OPPs with acetone as dopant. The photoionization of acetone molecules was induced by the ultraviolet irradiation to produce the reactant ions (Ac) 2 H + , which were employed to ionize the OPPs including fenthion, imidan, phosphamidon, dursban, dimethoate and isocarbophos via the proton transfer reaction. Due to the difference in proton affinity, the tested OPPs exhibited the different dopant-dependent manners. Based on this observation, the switching of dopant concentration was implemented to improve the selectivity of PP-IMS for OPPs detection. For instance, a mixture of fenthion, dursban and dimethoate was tested. By switching the concentration of doped acetone from 0.07 to 2.33 to 19.94mgL -1 , the ion peaks of fenthion and dursban were inhibited in succession, achieving the selective detection of dimethoate at last. In addition, another mixture of imidan and phosphamidon was initially detected by PP-IMS with a dose of 0.07mgL -1 acetone, indicating that their ion peaks were severely overlapped; when the concentration of doped acetone was switched to 19.94mgL -1 , the inhibition of imidan signals promised the accurate identification of phosphamidon in mixture. Finally, the PP-IMS in combination of switching dopant concentration was applied to detect the mixed fenthion, dursban and dimethoate in Chinese cabbage, demonstrating the applicability of proposed method to real samples. Copyright © 2017. Published by Elsevier B.V.

Applying Multi-Criteria Decision Analysis (MCDA) Simple Scoring as an Evidence-based HTA Methodology for Evaluating Off-Patent Pharmaceuticals (OPPs) in Emerging Markets.

PubMed

Brixner, Diana; Maniadakis, Nikos; Kaló, Zoltán; Hu, Shanlian; Shen, Jie; Wijaya, Kalman

2017-09-01

Off-patent pharmaceuticals (OPPs) represent more than 60% of the pharmaceutical market in many emerging countries, where they are frequently evaluated primarily on cost rather than with health technology assessment. OPPs are assumed to be identical to the originators. Branded and unbranded generic versions can, however, vary from the originator in active pharmaceutical ingredients, dosage, consistency formulation, excipients, manufacturing processes, and distribution, for example. These variables can alter the efficacy and safety of the product, negatively impacting both the anticipated cost savings and the population's health. In addition, many health care systems lack the resources or expertise to evaluate such products, and current assessment methods can be complex and difficult to adapt to a health system's needs. Multicriteria decision analysis (MCDA) simple scoring is an evidence-based health technology assessment methodology for evaluating OPPs, especially in emerging countries in which resources are limited but decision makers still must balance affordability with factors such as drug safety, level interchangeability, manufacturing site and active pharmaceutical ingredient quality, supply track record, and real-life outcomes. MCDA simple scoring can be applied to pharmaceutical pricing, reimbursement, formulary listing, and drug procurement. In November 2015, a workshop was held at the International Society for Pharmacoeconomics and Outcomes Research Annual Meeting in Milan to refine and prioritize criteria that can be used in MCDA simple scoring for OPPs, resulting in an example MCDA process and 22 prioritized criteria that health care systems in emerging countries can easily adapt to their own decision-making processes. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

The role of oxidized regenerate cellulose to prevent cosmetic defects in oncoplastic breast surgery.

PubMed

Franceschini, G; Visconti, G; Terribile, D; Fabbri, C; Magno, S; Di Leone, A; Salgarello, M; Masetti, R

2012-07-01

Breast conserving surgery (BCS) combined with postoperative radiotherapy has become the gold standard of locoregional treatment for the majority of patients with early-stage breast cancer, offering equivalent survival and improved body image and lifestyle scores as compared to mastectomy. In an attempt to optimize the oncologic safety and cosmetic results of BCS, oncoplastic procedures (OPP) have been introduced in recent years combining the best principles of surgical oncology with those of plastic surgery. However, even with the use of OPP, cosmetic outcomes may result unsatisfying when a large volume of parenchyma has to be removed, particularly in small-medium size breasts. The aim of this article is to report our preliminary results with the use of oxidized regenerate cellulose (ORC) (Tabotamp fibrillar, Johnson & Johnson; Ethicon, USA) as an agent to prevent cosmetic defects in patients undergoing OPP for breast cancer and to analyze the technical refinements that can enhance its efficacy in optimizing cosmetic defects. Different OPP are selected based on the location and size of the tumor as well as volume and shape of the breast. After excision of the tumor, glandular flaps are created by dissection of the residual parenchyma from the pectoralis and serratus muscles and from the skin. After careful haemostasis, five layers of ORC are positioned on the pectoralis major in the residual cavity and covered by advancement of the glandular flaps. Two additional layers of ORC are positioned above the flaps and covered by cutaneous-subcutaenous flaps. The use of ORC after OPP has shown promising preliminary results, indicating a good tolerability and positive effects on cosmesis. This simple and reliable surgical technique may allow not only to reduce the rate of post-operative bleeding and infection at the surgical site but also to improve cosmetic results.

Role of endothelin-1 in choroidal blood flow regulation during isometric exercise in healthy humans.

PubMed

Fuchsjäger-Mayrl, Gabriele; Luksch, Alexandra; Malec, Magdalena; Polska, Elzbieta; Wolzt, Michael; Schmetterer, Leopold

2003-02-01

There is evidence that the choroid has some autoregulatory capacity in response to changes in ocular perfusion pressure (OPP). The mediators of this response are hitherto unidentified. The hypothesis for the current study was that endothelin (ET)-1 and/or angiotensin (ANF)-II may be involved in choroidal vasoconstriction during an increase in OPP. To test this hypothesis a randomized, double-masked, placebo-controlled, three way crossover study was performed in 12 healthy male volunteers. Subjects received on different study days intravenous infusions of the specific ET(A) receptor antagonist BQ-123, the angiotensin converting enzyme inhibitor enalapril or placebo. During these infusion periods subjects were asked to squat for 6 minutes. Choroidal blood flow was measured using a confocal laser Doppler flowmeter and ocular perfusion pressure (OPP) was calculated from mean arterial pressure and intraocular pressure. BQ-123 and enalapril had no effect on basal blood pressure, pulse rate, intraocular pressure, or choroidal blood flow. During isometric exercise, a pronounced increase in mean arterial pressure paralleled by an increase in OPP was observed. Although choroidal blood flow slightly increased during squatting, the increase was much less pronounced than the increase in OPP, indicating some regulatory potential of the choroid. Enalapril did not alter the choroidal pressure-flow relationship during isometric exercise, but BQ-123 induced a significant leftward shift of the pressure-flow curve (P < 0.001). The present data indicate that ET-1, but not ANG II, plays a role in choroidal blood flow regulation during isometric exercise in healthy humans. Hence, impaired choroidal autoregulation in patients with ocular vascular diseases may arise from an altered endothelin system. Further studies in such patients are warranted to verify this hypothesis.

Familiarity with current practices of granting and maintaining privileges in pediatric interventional radiology--a worldwide survey of the members of the Society for Pediatric Interventional Radiology (SPIR).

PubMed

Harned, Roger K

2012-11-01

Physician credentialing is a complex process driven by the demand for quality improvement in health care. In the U.S., the Joint Commission Standard of 2007 has tied hospital accreditation to credentialing through mandated use of the Focused Professional Practice Evaluation (FPPE) and Ongoing Professional Practice Evaluation (OPPE). To assess pediatric interventional radiologists' knowledge of how institutions grant them privileges. Members of the Society for Pediatric Interventional Radiology (SPIR) were sent a web-based survey regarding credentialing. Of 122 members from 19 countries, 81 (66%) responded, and of these 81, 59 (73%) were familiar with their hospital's privileging process. Of 49 U.S. respondents and 32 non-U.S. respondents, 37 (76%) and 17 (53%), respectively, stated that interventional radiology credentialing was different from diagnostic radiology credentialing. Of the 49 U.S. respondents, 24 (49%) reported an OPPE, and of the 32 non-U.S. respondents, 8 (25%) reported an ongoing evaluation. The U.S. OPPE is performed at shorter intervals than its international equivalent. Four years after the Joint Commission defined the FPPE and OPPE, separate credentialing of pediatric interventional radiology from pediatric diagnostic radiology is more likely in the U.S. than internationally, and U.S. pediatric interventional radiologists are more likely to have a defined ongoing professional evaluation and to be evaluated every 6 months or more frequently. There are many SPIR members who do not know how they obtain privileges and/or are not knowingly subject to an OPPE. This lack of knowledge may affect future education of interventional radiologists as well as the definition of pediatric interventional radiology practices within individual institutions.

Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes

PubMed Central

Koledova, Vera V.; Shin, Hyeari; Park, Jennifer H.; Tan, Yew Ai; Sambanthamurthi, Ravigadevi

2018-01-01

Alzheimer's disease is a severe neurodegenerative disease characterized by the aggregation of amyloid-β peptide (Aβ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation. Multiple studies show that the soluble oligomers of Aβ42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic. We show that Aβ42 aggregation is inhibited in vitro by oil palm phenolics (OPP), an aqueous extract from the oil palm tree (Elaeis guineensis). The data shows that OPP inhibits stacking of β-pleated sheets, which is essential for oligomerization. We demonstrate the inhibition of Aβ42 aggregation by (1) mass spectrometry; (2) Congo Red dye binding; (3) 2D-IR spectroscopy; (4) dynamic light scattering; (5) transmission electron microscopy; and (6) transgenic yeast rescue assay. In the yeast rescue assay, OPP significantly reduces the cytotoxicity of aggregating neuropeptides in yeast genetically engineered to overexpress these peptides. The data shows that OPP inhibits (1) the aggregation of Aβ into oligomers; (2) stacking of β-pleated sheets; and (3) fibrillar growth and coalescence. These inhibitory effects prevent the formation of neurotoxic oligomers and hold potential as a means to reduce neuroinflammation and neuronal death and thereby may play some role in the prevention or treatment of Alzheimer's disease. PMID:29666700

78 FR 33785 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

...: [email protected] . 7. PP 2F8101. (EPA-HQ-OPP-2013-0226). Bayer CropScience LP, 2 T.W. Alexander Drive..., pads at 0.9 ppm; cattle/goat/hog/horse/sheep, fat at 0.5 ppm; cattle/goat/hog/horse/sheep, meat at 1...: [email protected] . 8. PP 2F8120. (EPA-HQ-OPP-2013-0015). Dow AgroSciences, 9330 Zionsville Road...

Variable Cycle Engine Control System Definition Study. Turbine Engine Technology Demonstrator Component Development Program, Project 668A. Controls Development Program

DTIC Science & Technology

1976-03-01

6- 18 6.5 Acceleration Mode - Purumeter Accuracy Comparison 6- 18 6.6 Acceleratiin Mode - Sensor Accuracy Cormpriwon 6- 0 6.7 .OP/P Surqt Control...Spool Speeds 6-42 6. 18 Fan Pressure Ratio Schedule 6-43 6.19 SFC with Control Mode 01 6-45 6.20 Optimal T4.1 vs. NHCl 6-46 6.21 Adjusted SFC for... 18 Intermediate Power to Idle Decelberation at Mach 2.2 and 36,089 Feet 7-39 7.19 Idle to Intermediate Power Acceleration at Mach 1.2 and 500 feet 7

Polydimethylsiloxane/metal-organic frameworks coated stir bar sorptive extraction coupled to gas chromatography-flame photometric detection for the determination of organophosphorus pesticides in environmental water samples.

PubMed

Xiao, Zuowei; He, Man; Chen, Beibei; Hu, Bin

2016-08-15

In this work, the metal-organic frameworks (MOFs), MIL-101-Cr-NH2 was synthesized via a direct hydrothermal method, and a polydimethylsiloxane (PDMS)/MIL-101-Cr-NH2 coated stir bar was prepared by sol-gel technique. Good reproducibility was obtained for the preparation of PDMS/MIL-101-Cr-NH2 coated stir bar with the relative standard deviations (RSDs) ranging from 3.7 to 5.2% (n=7) in one batch, and from 5.4 to 9.2% (n=7) among different batches. With the high surface area and rich benzene ring structure of MIL-101-Cr-NH2, the prepared PDMS/MIL-101-Cr-NH2 coated stir bar presented higher extraction efficiency for target organophosphorus pesticides (OPPs, including phorate, diazinon, malathion, fenthion, quinalphos and ethion) over PDMS coated stir bar. Based on it, a new method of PDMS/MIL-101-Cr-NH2 coated stir bar sorptive extraction (SBSE) coupled to gas chromatography-flame photometric detection (GC-FPD) was proposed for the determination of six OPPs in environmental water samples. The operation parameters affecting the extraction efficiency of SBSE, including extraction time, stirring rate, desorption time and ionic strength, were investigated. Under the optimal conditions, the limits of detection (S/N=3) were found to be in the range of 0.043-0.085μgL(-1) for the six target OPPs, and the linear range was 0.5-100μgL(-1) for malathion and 0.2-100μgL(-1) for other five OPPs. The RSDs of the proposed method evaluated at 1µgL(-1) for each OPP were in the range of 5.9-8.7% (intra-day, n=7) and 6.1-10.7% (inter-day, n=5), respectively. The enrichment factors were varied from 110 to 151-fold (theoretical enrichment factor was 200-fold). The proposed method was applied to the analysis of OPPs in East Lake and pond water samples with recoveries in the range of 89.3-115% and 80.0-113% for the spiked East Lake and pond water samples, respectively. Copyright © 2016 Elsevier B.V. All rights reserved.

Impact of prechlorination on organophosphorus pesticides during drinking water treatment: Removal and transformation to toxic oxon byproducts.

PubMed

Li, Wei; Wu, Ruiqing; Duan, Jinming; Saint, Christopher P; van Leeuwen, John

2016-11-15

Prechlorination is commonly used to minimize operational problems associated with biological growth as well as taste and odor control during drinking water treatment. However, prechlorination can also oxidise micropollutants into intermediate byproducts. This could impose profound effects on the safety of the finished water if the transformed byproducts are more toxic and less removable. This study investigated the effect of prechlorination on decomposition and subsequent removal of the four organophosphorus pesticides (OPPs): chlorpyrifos, diazinon, malathion and tolclofos-methyl using a simulated conventional water treatment process of powdered activated carbon assisted coagulation-sedimentation-filtration (PAC-CSF) and postchlorination. It was found that, following prechlorination, not only did the percentage of OPPs oxidation vary significantly, but also the concentration of transformed oxons, which are more toxic than their parent compounds, increased as the major identified oxidation byproducts in water. Removal of these oxons proved to be more difficult by the PAC-CSF than their parent OPPs, because they are more water soluble and more hydrophilic. Both the OPP oxidation and oxon formation increased with chlorine dose during prechlorination. Meanwhile, the continuing chlorination of OPPs by residual free chlorine during PAC-CSF further complicated the pesticide removal processes, generally resulting in a gradually increased formation of oxons. Moreover, in the final treatment stage of postchlorination, the more chlorine-reactive pesticides, malathion and diazinon, were completely oxidised and the formation of corresponding oxons was increased with the prechlorine dose. In contrast, a certain amount of the less chlorine-reactive pesticide tolclofos-methyl still remained in solution after postchlorination, accompanied by an increased formation of tolclofos-methyl oxon with prechlorine dose. Since the oxons are resistant to further oxidation and less adsorbable during the PAC-CSF process, the gross removal of these pesticides and their oxons decreased with increase of the prechlorine dose. This led to an accumulation of the more toxic oxons in the finished water, especially at higher chlorine doses during prechlorination. The significance of this work is the demonstration that, under circumstances where prechlorination is used and source water contains traces of OPPs, alternative practices should be prioritized to avoid the potential risks involved in consumption of the treated water. Copyright © 2016 Elsevier Ltd. All rights reserved.

Towards Patient-Centered Conflicts of Interest Policy

PubMed Central

Young, Peter D.; Xie, Dawei; Schmidt, Harald

2018-01-01

Financial conflicts of interest exist between industry and physicians, and these relationships have the power to influence physicians’ medical practice. Transparency about conflicts matters for ensuring adequate informed consent, controlling healthcare expenditure, and encouraging physicians’ reflection on professionalism. The US Centers for Medicare & Medicaid Services (CMS) launched the Open Payments Program (OPP) to publicly disclose and bring transparency to the relationships between industry and physicians in the United States. We set out to explore user awareness of the database and the ease of accessibility to disclosed information, however, as we show, both awareness and actual use are very low. Two practical policies can greatly enhance its intended function and help alleviate ethical tension. The first is to provide data for individual physicians not merely in absolute terms, but in meaningful context, that is, in relation to the zip code, city, and state averages. The second increases access to the OPP dataset by adding hyperlinks from physicians’ professional websites directly to their Open Payments disclosure pages. These changes considerably improve transparency and the utility of available data, and can furthermore enhance professionalism and accountability by encouraging physicians to reflect more actively on their own practices. PMID:29524935

Conserved Oligopeptide Permeases Modulate Sporulation Initiation in Clostridium difficile

PubMed Central

Edwards, Adrianne N.; Nawrocki, Kathryn L.

2014-01-01

The anaerobic gastrointestinal pathogen Clostridium difficile must form a metabolically dormant spore to survive in oxygenic environments and be transmitted from host to host. The regulatory factors by which C. difficile initiates and controls the early stages of sporulation in C. difficile are not highly conserved in other Clostridium or Bacillus species. Here, we investigated the role of two conserved oligopeptide permeases, Opp and App, in the regulation of sporulation in C. difficile. These permeases are known to positively affect sporulation in Bacillus species through the import of sporulation-specific quorum-sensing peptides. In contrast to other spore-forming bacteria, we discovered that inactivating these permeases in C. difficile resulted in the earlier expression of early sporulation genes and increased sporulation in vitro. Furthermore, disruption of opp and app resulted in greater virulence and increased the amounts of spores recovered from feces in the hamster model of C. difficile infection. Our data suggest that Opp and App indirectly inhibit sporulation, likely through the activities of the transcriptional regulator SinR and its inhibitor, SinI. Taken together, these results indicate that the Opp and App transporters serve a different function in controlling sporulation and virulence in C. difficile than in Bacillus subtilis and suggest that nutrient availability plays a significant role in pathogenesis and sporulation in vivo. This study suggests a link between the nutritional status of the environment and sporulation initiation in C. difficile. PMID:25069979

Hydrolysis mechanism of methyl parathion evidenced by Q-Exactive mass spectrometry.

PubMed

Liu, Yuan; Zhang, Caixiang; Liao, Xiaoping; Luo, Yinwen; Wu, Sisi; Wang, Jianwei

2015-12-01

Organophosphorus pesticides (OPPs), a kind of widely used pesticides, are currently attracting great attention due to their adverse effects on human central nervous systems, particularly in children. Although the hydrolysis behavior of OPPs has been studied well, its hydrolysis mechanism remained controversial, especially at various pH conditions, partly due to their relatively complex structures and abundant moieties that were prone to be attacked by nucleophiles. The Q-Exactive mass spectrometer, part of those hybrid high-resolution mass spectrometers (HRMS), was used to determine hydrolysis products of methyl parathion (MP), a kind of OPPs in situ buffer aqueous solution with pH ranging from 1 to 13 in this study. Most of the complex hydrolysis products of MP were identified due to the high sensitivity and accuracy of HRMS. The results demonstrated that the hydrolysis rate and pathway of MP were strong pH dependent. With the increase of pH, the hydrolysis rate of MP increased, and two different reaction mechanisms were identified: SN (2)@P pathway dominated the hydrolysis process at high pH (e.g., pH ≥ 11) while SN (2)@C was the main behavior at low pH (e.g., pH ≤ 9). This study helps understand the hydrolysis mechanism of OPPs at various pH and extends the use of Q-Exactive mass spectrometry in identifying organic pollutants and their degradation products in environmental matrices.

Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.

PubMed

Madeira, Joao Lo; Nishi, Mirian Y; Nakaguma, Marilena; Benedetti, Anna F; Biscotto, Isabela Peixoto; Fernandes, Thamiris; Pequeno, Thiago; Figueiredo, Thalita; Franca, Marcela M; Correa, Fernanda A; Otto, Aline P; Abrão, Milena; Miras, Mirta B; Santos, Silvana; Jorge, Alexander Al; Costalonga, Everlayny F; Mendonca, Berenice B; Arnhold, Ivo Jp; Carvalho, Luciani R

2017-12-01

Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian). We studied 23 index patients with CPHD and OPP (six familial and 17 sporadic) as well as 14 relatives. PROP1 was sequenced by the Sanger method in all except one sporadic case studied using a candidate gene panel. Multiplex ligation-dependent probe amplification (MLPA) was applied to one familial case in whom PROP1 failed to amplify by PCR. In the 13 patients without PROP1 mutations, HESX1 and LHX3 were sequenced by the Sanger method. We identified PROP1 mutations in 10 index cases. Three mutations were novel: one affecting the initiation codon (c.1A>G) and two affecting splicing sites, c.109+1G>A and c.342+1G>C. The known mutations, c.150delA (p.Arg53Aspfs*112), c.218G>A (p.Arg73His), c.263T>C (p.Phe88Ser) and c.301_302delAG (p.Leu102Cysfs*8), were also detected. MLPA confirmed complete PROP1 deletion in one family. We did not identify HESX1 and LHX3 mutations by Sanger. PROP1 mutations are a prevalent cause of congenital CPHD with OPP, and therefore, PROP1 sequencing must be the first step of molecular investigation in patients with CPHD and OPP, especially in populations with a high frequency of PROP1 mutations. In the absence of mutations, massively parallel sequencing is a promising approach. The high prevalence and diversity of PROP1 mutations is associated with the ethnic background of this cohort. © 2017 John Wiley & Sons Ltd.

5. Plat of Carlin Shops, 1884. Copied from Central Pacific ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Plat of Carlin Shops, 1884. Copied from Central Pacific Railroad bound book of station plats entitled 'Station Plans, CPRR, Mill City to Ogden,' in collection of Nevada Historical Society, Reno; credit Nevada Historical Society. Caption reads, 'Sand House - Hose Carriage Ho. - Casting Shed - Tank 'h' - Coal Shed 'I' and Iron Rack - finished in Oct. 1882. Tank 'c' built Nov. 1883 - Old Tank opp. & near main track taken down Nov. '83. E.C. Pierce's boarding house built May 1884. 172' old 1' pipe laid to Boarding house May 1884. 142 ft. 1' gas pipe - 2 Globe Valves laid to Div. Sup'ts Office Sept 1884.' Engine Stores Building is shown as building k. - Southern Pacific Railroad, Carlin Shops, Foot of Sixth Street, Carlin, Elko County, NV

Potential for bioremediation of agro-industrial effluents with high loads of pesticides by selected fungi.

PubMed

Karas, Panagiotis A; Perruchon, Chiara; Exarhou, Katerina; Ehaliotis, Constantinos; Karpouzas, Dimitrios G

2011-02-01

Wastewaters from the fruit packaging industry contain a high pesticide load and require treatment before their environmental discharge. We provide first evidence for the potential bioremediation of these wastewaters. Three white rot fungi (WRF) (Phanerochaete chrysosporium, Trametes versicolor, Pleurotus ostreatus) and an Aspergillus niger strain were tested in straw extract medium (StEM) and soil extract medium (SEM) for degrading the pesticides thiabendazole (TBZ), imazalil (IMZ), thiophanate methyl (TM), ortho-phenylphenol (OPP), diphenylamine (DPA) and chlorpyrifos (CHL). Peroxidase (LiP, MnP) and laccase (Lac) activity was also determined to investigate their involvement in pesticide degradation. T. versicolor and P. ostreatus were the most efficient degraders and degraded all pesticides (10 mg l⁻¹) except TBZ, with maximum efficiency in StEM. The phenolic pesticides OPP and DPA were rapidly degraded by these two fungi with a concurrent increase in MnP and Lac activity. In contrast, these enzymes were not associated with the degradation of CHL, IMZ and TM implying the involvement of other enzymes. T. versicolor degraded spillage-level pesticide concentrations (50 mg l⁻¹) either fully (DPA, OPP) or partially (TBZ, IMZ). The fungus was also able to rapidly degrade a mixture of TM/DPA (50 mg l⁻¹), whereas it failed to degrade IMZ and TBZ when supplied in a mixture with OPP. Overall, T. versicolor and P. ostreatus showed great potential for the bioremediation of wastewaters from the fruit packaging industry. However, degradation of TBZ should be also achieved before further scaling up.

Conserved oligopeptide permeases modulate sporulation initiation in Clostridium difficile.

PubMed

Edwards, Adrianne N; Nawrocki, Kathryn L; McBride, Shonna M

2014-10-01

The anaerobic gastrointestinal pathogen Clostridium difficile must form a metabolically dormant spore to survive in oxygenic environments and be transmitted from host to host. The regulatory factors by which C. difficile initiates and controls the early stages of sporulation in C. difficile are not highly conserved in other Clostridium or Bacillus species. Here, we investigated the role of two conserved oligopeptide permeases, Opp and App, in the regulation of sporulation in C. difficile. These permeases are known to positively affect sporulation in Bacillus species through the import of sporulation-specific quorum-sensing peptides. In contrast to other spore-forming bacteria, we discovered that inactivating these permeases in C. difficile resulted in the earlier expression of early sporulation genes and increased sporulation in vitro. Furthermore, disruption of opp and app resulted in greater virulence and increased the amounts of spores recovered from feces in the hamster model of C. difficile infection. Our data suggest that Opp and App indirectly inhibit sporulation, likely through the activities of the transcriptional regulator SinR and its inhibitor, SinI. Taken together, these results indicate that the Opp and App transporters serve a different function in controlling sporulation and virulence in C. difficile than in Bacillus subtilis and suggest that nutrient availability plays a significant role in pathogenesis and sporulation in vivo. This study suggests a link between the nutritional status of the environment and sporulation initiation in C. difficile. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Economic evaluation of Helicobacter pylori eradication in the CADET-Hp randomized controlled trial of H. pylori-positive primary care patients with uninvestigated dyspepsia.

PubMed

Chiba, N; Veldhuyzen Van Zanten, S J O; Escobedo, S; Grace, E; Lee, J; Sinclair, P; Barkun, A; Armstrong, D; Thomson, A B R

2004-02-01

Adult Helicobacter pylori-positive patients by 13C-urea breath test with uninvestigated dyspepsia symptoms were randomized to 1-week eradication treatment with omeprazole, metronidazole and clarithromycin (OMC) vs. omeprazole and placebo antimicrobials (OPP) in the Canadian Adult Dyspepsia Empiric Treatment-H. pylori-positive (CADET-Hp) study. To perform an economic evaluation of this 1-year study. Following blind eradication treatment, family practitioners managed patients according to their usual practices. Health resource utilization information was collected prospectively. From the mean costs of the health resources consumed and the treatment outcomes, the incremental cost-effectiveness ratios and incremental net benefits of eradication treatment vs. OPP were determined. Eradication therapy significantly improved dyspepsia symptoms (treatment success: OMC, 50%; OPP, 36%; P = 0.02). The incremental cost-effectiveness ratio of OMC vs. OPP was - 387 Canadian dollars (CAD$) per treatment success (90% CI, - CAD$1707, CAD$607), indicating a lower cost with treatment success. The incremental net benefit analysis showed that H. pylori eradication was cost-effective if the willingness-to-pay value exceeded a nominal figure of CAD$100 from a health service perspective or CAD$607 from the societal perspective. In uninvestigated patients presenting with dyspepsia at the primary care level, eradication of H. pylori in those who are H. pylori positive leads to a cost-effective improvement in dyspepsia symptoms compared with a strategy of not eradicating H. pylori in these patients.

The use of drilling by the U.S. Antarctic program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wade, M.C.; Webb, J.W.; Hedberg, W.H.

1994-08-01

This report on drilling in the Antarctic has been prepared by the U.S. National Science Foundation (NSF) to assist principal investigators and others in complying with the National Environmental Policy Act (NEPA) and the Antarctic Treaty of 1961. Implementing regulations for NEPA are spelled out in 40 CFR 1500-1508. Environmental protection under the Antarctic Treaty is addressed in the Protocol on Environmental Protection to the Antarctic Treaty (hereafter referred to as the Protocol), which was adopted by 26 countries in 1991. In the United States, responsibility for compliance with these requirements rests with the NSF Office of Polar Programs (OPP),more » which manages the U.S. Antarctic Program (USAP). The USAP recognizes the potentially profound impacts that its presence and activities can have on the antarctic environment. In its extensive support of operations and research in Antarctica, the USAP uses all practical means to foster and maintain natural conditions while supporting scientific endeavors in a safe and healthful manner. Reducing human impacts on the antarctic environment is a major goal of the USAP. The USAP`s operating philosophy is based on broad yet reasonable and practical assumptions concerning environmental protection. The USAP maintains three year-round stations on the continent to support scientific research. Research and associated support operations at these stations and camps sometimes involve drilling into ice, soil, or ocean sediments. In order to comply with NEPA and the Protocol, it is necessary for principal investigators and others to assess the environmental effects of drilling. This report has been prepared to assist in this process by describing various drilling technologies currently available for use in Antarctica, generally characterizing the potential environmental impacts associated with these drilling techniques, and identifying possible mitigation measures to reduce impacts.« less

Evaluation of a mid-career investigator career development award: Assessing the ability of OppNet K18 awardees to obtain NIH follow-on research funding.

PubMed

Pomeroy-Carter, Cassidy A; Williams, Sharon R; Han, Xueying; Elwood, William N; Zuckerman, Brian L

2018-01-01

The National Institutes of Health (NIH) K18 award mechanism provides funded opportunities for established investigators to gain knowledge in fields outside of their primary disciplines, but outcomes associated with these awards have not been evaluated to date. NIH's Basic Behavioral and Social Sciences Opportunity Network (OppNet) is one of the few initiatives that has used this award mechanism. We explored how the unique features of K18 awards affect the ability of recipients to obtain follow-on NIH research funding. We compared outcomes (ability to obtain follow-on funding and interval between receipt of the primary award and receipt of the first follow-on award) associated with OppNet K18 awards to findings from evaluations of other NIH career development (K) awards, which usually target early-career investigators. We hypothesized that K18 award recipients might be (1) more successful than are other K award recipients in obtaining follow-on NIH research funding due to their career experience or (2) less successful due to the competing demands of other projects. By analyzing follow-on NIH research awards and interview data, we found that OppNet K18 award recipients were at least as successful as were other K award recipients in obtaining follow-on funding and may have been more successful by certain measures. K18 awards produce their outcomes with a lower investment per investigator than do other K awards, suggesting continued or enhanced use of the mechanism.

[Transcutaneous Electrical Stimulation Undergoing Emergency Treatment of Zusanli (ST 36) Is Beneficial to Rescued Organophosphorus Pesticide Poisoning Patients].

PubMed

Gao, Hui; Zhao, Mai-liang; Zhou, Ai-min; Zhang, Sheng; Song, Zhong-hai; Guo, Wen-ping; Deng, Zhi-an

2015-12-01

To observe the effect of transcutaneous acupoint electrical stimulation (TAES) of Zusanli (ST 36) on gastrointestinal activities in organophosphorus pesticide poisoning (OPP) patients undergoing emergency treatment so as to explore its action in scavenging gastrointestinal toxicant. A total of 116 OPP patients were randomly divided into control group and TAES group (n=58 in each group) according to the simple random sampling method. All the patients received comprehensive treatment including gastric lavage, catharsis, oral administration of atropine Pralidoxime Chloride, Omeprazole, etc. For patients of the TAES group, TAES stimulation (30 Hz/60 Hz, 15-20 mA) was applied to bilateral Zusanli (ST 36) for 30 min, 3 times a day till black stool was discharged. The vomiting times after catharsis, the time of the first defecation and black stool discharge, the dosage of atropine and the length of patient stay in hospital were recorded. Of the two 58 cases of OPP patients in the control and TAES groups, 11 (18.9%) and 3 (5.2%) underwent vomiting after catharsis, being significantly lower in the TAES group (P<0.05). Compared with the control group, the time of first defecation and black stool discharge, the dosage of the administrated atropine and the time of hospitalization were significantly lower in the TAES group (P<0.05). TAES of ST 36 may lower incidence of emesis, enhance the cathartic effect, promote gastrointestinal poison discharge, reduce total atropine dosage and shorten the hospitalization time in OPP patients, favoring the patient's rehabilitation.

Evaluation of a mid-career investigator career development award: Assessing the ability of OppNet K18 awardees to obtain NIH follow-on research funding

PubMed Central

Williams, Sharon R.; Han, Xueying; Elwood, William N.; Zuckerman, Brian L.

2018-01-01

The National Institutes of Health (NIH) K18 award mechanism provides funded opportunities for established investigators to gain knowledge in fields outside of their primary disciplines, but outcomes associated with these awards have not been evaluated to date. NIH’s Basic Behavioral and Social Sciences Opportunity Network (OppNet) is one of the few initiatives that has used this award mechanism. We explored how the unique features of K18 awards affect the ability of recipients to obtain follow-on NIH research funding. We compared outcomes (ability to obtain follow-on funding and interval between receipt of the primary award and receipt of the first follow-on award) associated with OppNet K18 awards to findings from evaluations of other NIH career development (K) awards, which usually target early-career investigators. We hypothesized that K18 award recipients might be (1) more successful than are other K award recipients in obtaining follow-on NIH research funding due to their career experience or (2) less successful due to the competing demands of other projects. By analyzing follow-on NIH research awards and interview data, we found that OppNet K18 award recipients were at least as successful as were other K award recipients in obtaining follow-on funding and may have been more successful by certain measures. K18 awards produce their outcomes with a lower investment per investigator than do other K awards, suggesting continued or enhanced use of the mechanism. PMID:29438411

Effective Management of Ocean Biogeochemistry and Ecological Data: the BCO-DMO Story

NASA Astrophysics Data System (ADS)

Chandler, C. L.; Groman, R. C.; Allison, M. D.; Wiebe, P. H.; Glover, D. M.; Gegg, S. R.

2012-04-01

Data availability expectations of the research community, environmental management decision makers, and funding agency representatives are changing. Consequently, data management practices in many science communities are changing as well. In an effort to improve access to data generated by ocean biogeochemistry and ecological researchers funded by the United States (US) National Science Foundation (NSF) Division of Ocean Sciences (OCE), the Biological and Chemical Oceanography Data Management Office (BCO-DMO) was created in late 2006. Currently, the main BCO-DMO objective is to ensure availability of data resulting from select OCE and Office of Polar Programs (OPP) research awards granted by the US NSF. An important requirement for the BCO-DMO data management system is that it provides open access to data that are supported by sufficient metadata to enable data discovery and accurate reuse. The office manages and serves all types of oceanographic data (in situ, experimental, model results) generated during the research process and contributed by the originating investigators from large national programs and medium-sized collaborative research projects, as well as researchers with single investigator awards. BCO-DMO staff members have made strategic use of standards and use of terms from controlled vocabularies while balancing the need to maintain flexible data ingest systems that accommodate the heterogeneous nature of ocean biogeochemistry and ecological research data. Many of the discrete ocean biogeochemistry data sets managed by BCO-DMO are still acquired manually, often with prototype sensor systems. Data sets such as these that are not "born-digital" present a significant management challenge. Use of multiple levels of term-mappings and development of an ontology has enabled BCO-DMO to incorporate a semantically enabled faceted search into the data access system that will improve data access through enhanced data discovery. BCO-DMO involves an ongoing collaboration between data managers and marine scientists funded by the US NSF. BCO-DMO staff members work with investigators throughout the data life cycle, beginning with the data management plan that is part of the original proposal, during cruise planning and experimental design, through data reporting to meet funding agency requirements and finally to submission of final data sets for publication and final archive in a permanent data center. It is important to note that support from and continued active involvement of the NSF program managers has been a significant contributor to the success of this developing system. URL: http://bco-dmo.org/

Sol-gel polydimethylsiloxane/poly(vinylalcohol)-coated stir bar sorptive extraction of organophosphorus pesticides in honey and their determination by large volume injection GC.

PubMed

Yu, Chunhe; Hu, Bin

2009-01-01

A PDMS/poly(vinylalcohol) (PDMS/PVA) film prepared through a sol-gel process was coated on stir bars for sorptive extraction, followed by liquid desorption and large volume injection-GC-flame photometric detector (LVI-GC-FPD) for the determination of five organophosphorus pesticides (OPPs) (phorate, fenitrothion, malathion, parathion, and quinalphos) in honey. The preparation reproducibility of PDMS/PVA-coated stir bar ranged from 4.3 to 13.4% (n = 4) in one batch, and from 6.0 to 12.6% (n = 4) in batch to batch. And one prepared stir bar can be used for more than 50 times without apparent coating loss. The significant parameters affecting stir bar sorptive extraction (SBSE) were investigated and optimized. The LODs for five OPPs ranged from 0.013 (parathion) to 0.081 microg/L (phorate) with the RSDs ranging from 5.3 to 14.2% (c = 1 microg/L, n = 6). The proposed method was successfully applied to the analysis of five OPPs in honey.

Opinion of the Scientific Committee on Consumer Safety (SCCS) - Revision of the opinion on o-Phenylphenol, Sodium o-phenylphenate and Potassium o-phenylphenate (OPP), in cosmetic products.

PubMed

Bernauer, Ulrike

2016-08-01

o-Phenylphenol, Sodium o-phenylphenate, Potassium o-phenylphenate, CAS n. 90-43-7, 132-27-4, 13707-65-8 as preservatives are regulated in Annex V/7 of the Cosmetics Regulation (EC) n. 1223/2009 at a maximum concentration of 0.2% (as phenol). In February 2013, the Commission received a risk assessment submitted by the French Agency ANSM (Agence nationale de sécurité des médicaments et des produits de santé) which rose concerns about the use of o-Phenylphenol as preservatives in cosmetic products. In the context of the ANSM report (Evaluation du risque lié à l'utilisation de l'orthophénylphénol CAS n. 90-43-7 dans les produits cosmétiques) o-Phenylphenol has been identified as likely to be an endocrine disruptor. The report concludes that the maximum authorised concentration (currently of 0.2%) of o-Phenylphenol for use as a preservative should be revised due to low margin of safety. In January 2014, in response to a call for data on o-Phenylphenol by the Commission, Industry submitted a safety dossier in order to defend the current use of o-Phenylphenol, Sodium o-phenylphenate, Potassium o-phenylphenate, CAS n. 90-43-7, 132-27-4, 13707- 65-8 as preservatives in cosmetic formulations at a maximum concentration of 0.2% (as phenol). o-Phenylphenol as preservative with a maximum concentration of 0.2% in leave-on cosmetic products is not safe. Also, in view of further exposures including noncosmetic uses (see Anses, 2014), the maximum concentration of o-Phenylphenol in leave-on cosmetic products should be lowered. However, the proposed maximum use concentration of up to 0.15% by the applicant can be considered safe. The use of o-Phenylphenol as preservative with a maximum concentration of 0.2% in rinse-off cosmetic products is considered safe. Based on the information provided, no conclusions of safe use can be drawn for Sodium o-phenylphenate and Potassium o-phenylphenate. In vitro data indicate an absent or very weak binding affinity of OPP to the oestrogen receptor, in line with limited stimulation of proliferation in oestrogen responsive cells. No information is available on androgenic and anti-androgenic effects of OPP in vitro. Agonistic or antagonistic effects on thyroid hormones were not observed with OPP. There might be a potential of injury to the vision system attributable to OPP. Aggregate exposure to OPP should be considered. Copyright © 2016. Published by Elsevier Inc.

Utilizing the Antarctic Master Directory to find orphan datasets

NASA Astrophysics Data System (ADS)

Bonczkowski, J.; Carbotte, S. M.; Arko, R. A.; Grebas, S. K.

2011-12-01

While most Antarctic data are housed at an established disciplinary-specific data repository, there are data types for which no suitable repository exists. In some cases, these "orphan" data, without an appropriate national archive, are served from local servers by the principal investigators who produced the data. There are many pitfalls with data served privately, including the frequent lack of adequate documentation to ensure the data can be understood by others for re-use and the impermanence of personal web sites. For example, if an investigator leaves an institution and the data moves, the link published is no longer accessible. To ensure continued availability of data, submission to long-term national data repositories is needed. As stated in the National Science Foundation Office of Polar Programs (NSF/OPP) Guidelines and Award Conditions for Scientific Data, investigators are obligated to submit their data for curation and long-term preservation; this includes the registration of a dataset description into the Antarctic Master Directory (AMD), http://gcmd.nasa.gov/Data/portals/amd/. The AMD is a Web-based, searchable directory of thousands of dataset descriptions, known as DIF records, submitted by scientists from over 20 countries. It serves as a node of the International Directory Network/Global Change Master Directory (IDN/GCMD). The US Antarctic Program Data Coordination Center (USAP-DCC), http://www.usap-data.org/, funded through NSF/OPP, was established in 2007 to help streamline the process of data submission and DIF record creation. When data does not quite fit within any existing disciplinary repository, it can be registered within the USAP-DCC as the fallback data repository. Within the scope of the USAP-DCC we undertook the challenge of discovering and "rescuing" orphan datasets currently registered within the AMD. In order to find which DIF records led to data served privately, all records relating to US data within the AMD were parsed. After identifying the records containing a URL leading to a national data center or other disciplinary data repository, the remaining records were individually inspected for data type, format, and quality of metadata and then assessed to determine how best to preserve. Of the records reviewed, those for which appropriate repositories could be identified were submitted. An additional 35 were deemed acceptable in quality of metadata to register in the USAP-DCC. The content of these datasets were varied in nature, ranging from penguin counts to paleo-geologic maps to results of meteorological models all of which are discoverable through our search interface, http://www.usap-data.org/search.php. The remaining 40 records linked to either no data or had inadequate documentation for preservation highlighting the danger of serving datasets on local servers where minimal metadata standards can not be enforced and long-term access can not be ensured.

Retinal vessel oxygen saturation in a healthy young Chinese population.

PubMed

Yang, Wei; Fu, Yue; Dong, Yanmin; Lin, Leilei; Huang, Xia; Li, Yujie; Lin, Xiaofeng; Gao, Qianying

2016-06-01

To measure retinal vessel oxygen saturation in a healthy young Chinese population and to determine the effects of multiple factors (gender, age, dioptre, vessel diameter and ocular perfusion pressure - OPP) on retinal oxygen saturation. A total of 126 healthy Chinese individuals aged from 19 to 30 were included in this study. A retinal oximeter (Oxymap T1) was used to measure retinal vessel oxygen saturation by retinal imaging at two different wavelengths. The mean retinal vessel oxygen saturation (Sat_O2 ) of arterioles, venules and arteriovenous (AV) difference overall and in four separate quadrants were measured. Intra-ocular pressure, blood pressure, finger pulse oximetry value, vessel diameter and dioptre were also measured. The correlations between OPP and dioptre, OPP and vessel diameter, and dioptre and vessel diameter were analysed. And the effects of multiple factors on the retinal oxygen saturation were analysed. The mean oxygen saturation was 93.2 ± 6.3% in the retinal arterioles, 60.4 ± 5.3% in venules and 32.9 ± 6.4% in AV difference. The temporal quadrants had lower measurements of arteriolar and venular oxygen saturation and AV difference compared with nasal quadrants (p < 0.001). The oxygen saturation of the arterioles, venules and AV difference were unaffected by any unique factor. Arteriolar and venular retinal oxygen saturation correlated negatively with the product of dioptre and OPP. Arteriolar retinal oxygen saturation correlated positively with the product of dioptre and vessel diameter. This study provided a normal reference of Sat_O2 in healthy young Chinese individuals. It was a reflection of the normal state of retinal oxygen metabolism affected by several factors. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

An Innovative Rapid Method for Analysis of 10 Organophosphorus Pesticide Residues in Wheat by HS-SPME-GC-FPD/MSD.

PubMed

Du, Xin; Ren, YongLin; Beckett, Stephen J

2016-01-01

The rapid detection of pesticide residues in wheat has become a top food security priority. A solvent-free headspace solid-phase microextraction (HS-SPME) has been evaluated for rapid screening of organophosphorus pesticide (OPP) residues in wheat with high sensitivity. Individual wheat samples (1.7 g), spiked with 10 OPPs, were placed in a 4 mL sealed amber glass vial and heated at 60°C for 45 min. During this time, the OPP residues were extracted with a 50 μm/30 μm divinylbenzene (DVB)/carboxen (CAR)/plasma desorption mass spectroscopy polydimethylsiloxane (PDMS) fiber from the headspace above the sample. The fiber was then removed and injected into the GC injection port at 250°C for desorption of the extracted chemicals. The multiple residues were identified by a GC mass spectrometer detector (GC-MSD) and quantified with a GC flame photometric detector (GC-FPD). Seven spiked levels of 10 OPPs on wheat were analyzed. The GC responses for a 50 μm/30 μm DVB/CAR/PDMS fiber increased with increasing spiking levels, yielding significant (R(2) > 0.98) linear regressions. The lowest LODs of the multiple pesticide standards were evaluated under the conditions of the validation study in a range of levels from 0 (control) to 100 ng of pesticide residue per g of wheat that separated on a low-polar GC capillary column (Agilent DB-35UI). The results of the HS-SPME method were compared with the QuEChERS AOAC 2007.01 method and they showed several advantages over the latter. These included improved sensitivity, selectivity, and simplicity.

Determination of organophosphorus pesticides in bovine tissue by an on-line coupled matrix solid-phase dispersion-solid phase extraction-high performance liquid chromatography with diode array detection method.

PubMed

Gutiérrez Valencia, Tania M; García de Llasera, Martha P

2011-09-28

A miniaturized method based on matrix solid-phase dispersion coupled to solid phase extraction and high performance liquid chromatography with diode array detection (MSPD-SPE-HPLC/DAD) was developed for the trace simultaneous determination of the following organophosphorus pesticides (OPPs) in bovine tissue: parathion-methyl, fenitrothion, parathion, chlorfenvinphos, diazinon, ethion, fenchlorphos, chlorpyrifos and carbophenothion. To perform the coupling between MSPD and SPE, 0.05 g of sample was dispersed with 0.2 g of C(18) silica sorbent and packed into a stainless steel cartridge containing 0.05 g of silica gel in the bottom. After a clean-up of high and medium polarity interferences with water and an acetonitrile:water mixture, the OPPs were desorbed from the MSPD cartridge with pure acetonitrile and directly transferred to a dynamic mixing chamber for dilution with water and preconcentration into an SPE 20 mm × 2.0 mm I.D. C(18) silica column. Subsequently, the OPPs were eluted on-line with the chromatographic mobile phase to the analytical column and the diode array detector for their separation and detection, respectively. The method was validated and yielded recovery values between 91% and 101% and precision values, expressed as relative standard deviations (RSD), which were less than or equal to 12%. Linearity was good and ranged from 0.5 to 10 μg g(-1), and the limits of detection of the OPPs were in the range of 0.04-0.25 μg g(-1). The method was satisfactorily applied to the analysis of real samples and is recommended for food control, research efforts when sample amounts are limited, and laboratories that have ordinary chromatographic instrumentation. Copyright © 2011 Elsevier B.V. All rights reserved.

An Evidence Framework for Off-Patent Pharmaceutical Review (EFOR) for Health Technology Assessment in Emerging Markets.

PubMed

Brixner, Diana; Kaló, Zoltán; Maniadakis, Nikos; Kim, Kyoo; Wijaya, Kalman

2018-03-29

This article introduces an Evidence Framework for Off-Patent Pharmaceutical Review (EFOR), which establishes value-based criteria in a template that manufacturers use to provide evidence showing how their products meet those criteria. Health authorities in emerging markets can then use the evidence presented in the EFOR to evaluate off-patent pharmaceuticals (OPPs) in a consistent, transparent, and evidence-based manner to support policy decisions, including pricing, reimbursement, formulary listing, and drug procurement. A literature search found no multi-criteria evidence framework for evaluating OPPs in emerging markets. An International Outcomes Research Board (IORB) of academia and industry experts conducted extensive research, meetings, and workshops to define high-priority criteria to incorporate into an evidence-based health technology assessment (HTA) tool using the multi-criteria decision analysis (MCDA) technique. The resulting framework was further tailored for country-specific needs in workshops in three emerging countries (Kazakhstan, Vietnam, and Indonesia). The IORB defined nine criteria four categories (Product, Manufacturing, Service, and Value Assessment), which OPP manufacturers can use to provide evidence for reimbursement and health policy decision making. Then the IORB developed the EFOR as a base case document, which can be adapted and used as a template by health authorities in emerging countries. Emerging countries have a significant need for an HTA tool that balances affordability with accurate evidence showing the value differentiation of OPPs. The value attributes in this setting often are different from those in developed markets, which emphasize new products and have high regulation and manufacturing standards. The EFOR is an easy-to-use, adaptable framework that emerging countries can use to increase the consistency, transparency, and effectiveness of drug decision making. The open source EFOR is available as Supplemental Materials. Copyright © 2018. Published by Elsevier Inc.

Antigen-specific, CD4+CD25+ regulatory T cell clones induced in Peyer's patches.

PubMed

Tsuji, Noriko M; Mizumachi, Koko; Kurisaki, Jun-Ichi

2003-04-01

Since intestine is exposed to numerous exogenous antigens such as food and commensal bacteria, the organ bears efficient mechanisms for establishment of tolerance and induction of regulatory T cells (T(reg)). Intestinal and inducible T(reg) include T(r)1-like and T(h)3 cells whose major effector molecules are IL-10 and transforming growth factor (TGF)-beta. These antigen-specific T(reg) are expected to become clinical targets to modify the inflammatory immune response associated with allergy, autoimmune diseases and transplantation. In the present study, we characterized the antigen-specific T(reg) induced in the intestine by orally administering high-dose beta-lactoglobulin (BLG) to BALB/c mice. Seven days after feeding, only Peyer's patch (PP) cells among different organs exerted significant suppressive effect on antibody production upon in vitro BLG stimulation. This suppressive effect was also prominent in six BLG-specific CD4(+) T cell clones (OPP1-6) established from PP from mice orally administered with high doses of BLG and was partially reversed by antibodies to TGF-beta. Intravenous transfer of OPP2 efficiently suppressed BLG-specific IgG1 production in serum following immunization, indicating the role of such T(reg) in the systemic tolerance after oral administration of antigen (oral tolerance). OPP clones secrete TGF-beta, IFN-gamma and low levels of IL-10, a cytokine pattern similar to that secreted by anergic T cells. OPP clones bear a CD4(+)CD25(+) phenotype and show significantly lower proliferative response compared to T(h)0 clones. This lower response is recovered by the addition of IL-2. Thus, antigen-specific CD4(+)CD25(+) T(reg), which have characteristics of anergic cells and actively suppress antibody production are induced in PP upon oral administration of protein antigen.

Organochlorine and organophosphorus pesticide residues in fodder and milk samples along Musi river belt, India.

PubMed

Kotinagu, Korrapati; Krishnaiah, Nelapati

2015-04-01

The present study was conducted to find the organochlorine pesticide (OCP) and organophosphorus pesticide (OPP) residues in fodder and milk samples along Musi river belt, India. Fodder and milk samples collected from the six zones of Musi river belt, Hyderabad India were analyzed by gas chromatography with electron capture detector for OCP residues and pulsated flame photometric detector for the presence of OPP residues. The gas chromatographic analysis of fodder samples of Zone 5 of Musi river showed the residues of dicofol at concentration of 0.07±0.0007 (0.071-0.077). Among organophosphorus compounds, dimetheoate was present in milk samples collected from Zone 6 at a level of 0.13±0.006 (0.111-0.167). The residues of OCPs, OPPs and cyclodies were below the detection limit in the remaining fodder and milk samples collected from Musi river belt in the present study. The results indicate that the pesticide residues in fodder and milk samples were well below the maximum residue level (MRL) values, whereas dicofol in fodder and dimethoate in milk were slightly above the MRL values specified by EU and CODEX.

Organochlorine and organophosphorus pesticide residues in fodder and milk samples along Musi river belt, India

PubMed Central

Kotinagu, Korrapati; Krishnaiah, Nelapati

2015-01-01

Aim: The present study was conducted to find the organochlorine pesticide (OCP) and organophosphorus pesticide (OPP) residues in fodder and milk samples along Musi river belt, India. Materials and Methods: Fodder and milk samples collected from the six zones of Musi river belt, Hyderabad India were analyzed by gas chromatography with electron capture detector for OCP residues and pulsated flame photometric detector for the presence of OPP residues. Results: The gas chromatographic analysis of fodder samples of Zone 5 of Musi river showed the residues of dicofol at concentration of 0.07±0.0007 (0.071-0.077). Among organophosphorus compounds, dimetheoate was present in milk samples collected from Zone 6 at a level of 0.13±0.006 (0.111-0.167). The residues of OCPs, OPPs and cyclodies were below the detection limit in the remaining fodder and milk samples collected from Musi river belt in the present study. Conclusion: The results indicate that the pesticide residues in fodder and milk samples were well below the maximum residue level (MRL) values, whereas dicofol in fodder and dimethoate in milk were slightly above the MRL values specified by EU and CODEX. PMID:27047132

Evaluation of the effect of elevated intraocular pressure and reduced ocular perfusion pressure on retinal capillary bed filling and total retinal blood flow in rats by OMAG/OCT.

PubMed

Zhi, Zhongwei; Cepurna, William; Johnson, Elaine; Jayaram, Hari; Morrison, John; Wang, Ruikang K

2015-09-01

To determine if retinal capillary filling is preserved in the face of acutely elevated intraocular pressure (IOP) in anesthetized rats, despite a reduction in total retinal blood flow (RBF), using optical microangiography/optical coherence tomography (OMAG/OCT). OMAG provided the capability of depth-resolved imaging of the retinal microvasculature down to the capillary level. Doppler OCT was applied to measure the total RBF using an enface integration approach. The microvascular pattern, capillary density, and total RBF were monitored in vivo as the IOP was increased from 10 to 100mmHg in 10mmHg intervals and returned back to 10mmHg. In animals with mean arterial pressure (MAP) of 102±4mmHg (n=10), when IOP was increased from 0 to 100mmHg, the capillary density remained at or above 80% of baseline for the IOP up to 60mmHg [or ocular perfusion pressure (OPP) at 40mmHg]. This was then decreased, achieving 60% of baseline at IOP 70mmHg and OPP of 30mmHg. Total RBF was unaffected by moderate increases in IOP up to 30mmHg, beyond which total RBF decreased linearly, reaching 50% of baseline at IOP 60mmHg and OPP 40mmHg. Both capillary density and total RBF were totally extinguished at 100mmHg, but fully recovered when IOP returned to baseline. By comparison, a separate group of animals with lower MAP (mean=75±6mmHg, n=7) demonstrated comparable decreases in both capillary filling and total RBF at IOPs that were 20mmHg lower than in the initial group. Both were totally extinguished at 80mmHg, but fully recovered when IOP returned to baseline. Relationships of both parameters to OPP were unchanged. Retinal capillary filling and total RBF responses to IOP elevation can be monitored non-invasively by OMAG/OCT and both are influenced by OPP. Retinal capillary filling was relatively preserved down to a perfusion pressure of 40mmHg, despite a linear reduction in total RBF. Copyright © 2015 Elsevier Inc. All rights reserved.

Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study.

PubMed

Pritt, Bobbi S; Mead, Paul S; Johnson, Diep K Hoang; Neitzel, David F; Respicio-Kingry, Laurel B; Davis, Jeffrey P; Schiffman, Elizabeth; Sloan, Lynne M; Schriefer, Martin E; Replogle, Adam J; Paskewitz, Susan M; Ray, Julie A; Bjork, Jenna; Steward, Christopher R; Deedon, Alecia; Lee, Xia; Kingry, Luke C; Miller, Tracy K; Feist, Michelle A; Theel, Elitza S; Patel, Robin; Irish, Cole L; Petersen, Jeannine M

2016-05-01

Lyme borreliosis is the most common tick-borne disease in the northern hemisphere. It is a multisystem disease caused by Borrelia burgdorferi sensu lato genospecies and characterised by tissue localisation and low spirochaetaemia. In this study we aimed to describe a novel Borrelia species causing Lyme borreliosis in the USA. At the Mayo clinic, from 2003 to 2014, we tested routine clinical diagnostic specimens from patients in the USA with PCR targeting the oppA1 gene of B burgdorferi sensu lato. We identified positive specimens with an atypical PCR result (melting temperature outside of the expected range) by sequencing, microscopy, or culture. We collected Ixodes scapularis ticks from regions of suspected patient tick exposure and tested them by oppA1 PCR. 100 545 specimens were submitted by physicians for routine PCR from Jan 1, 2003 to Sept 30, 2014. From these samples, six clinical specimens (five blood, one synovial fluid) yielded an atypical oppA1 PCR product, but no atypical results were detected before 2012. Five of the six patients with atypical PCR results had presented with fever, four had diffuse or focal rash, three had symptoms suggestive of neurological inclusion, and two were admitted to hospital. The sixth patient presented with knee pain and swelling. Motile spirochaetes were seen in blood samples from one patient and cultured from blood samples from two patients. Among the five blood specimens, the median oppA1 copy number was 180 times higher than that in 13 specimens that tested positive for B burgdorferi sensu stricto during the same time period. Multigene sequencing identified the spirochaete as a novel B burgdorferi sensu lato genospecies. This same genospecies was detected in ticks collected at a probable patient exposure site. We describe a new pathogenic Borrelia burgdorferi sensu lato genospecies (candidatus Borrelia mayonii) in the upper midwestern USA, which causes Lyme borreliosis with unusually high spirochaetaemia. Clinicians should be aware of this new B burgdorferi sensu lato genospecies, its distinct clinical features, and the usefulness of oppA1 PCR for diagnosis. US Centers for Disease Control and Prevention Epidemiology and Laboratory Capacity for Infectious Diseases (ELC) Cooperative Agreement and Mayo Clinic Small Grant programme. Copyright © 2016 Elsevier Ltd. All rights reserved.

A systematic review on human exposure to organophosphorus pesticides in Iran.

PubMed

Shadboorestan, Amir; Vardanjani, Hossein Molavi; Abdollahi, Mohammad; Goharbari, Mohammad Hadi; Khanjani, Narges

2016-07-02

Human exposure to organophosphorus (OP) pesticides is a serious health challenge. We conducted a systematic review by searching international and national databases for published literature on any human exposure to OPs in Iran from 1990 to March 2015. Qualified papers were in two categories including studies in which biomarkers of exposure were assessed (n = 13; total no. of subjects = 759) and studies that had reported prevalence of OPs-induced poisoning (OPP) and mortality (n = 26; total no. of subjects = 5428). The mean level of activity of acetyl-cholinesterase and butyryl-cholinesterase were 68.65% and 74.2%, respectively. Overall proportion (%) of OPP was estimated (16; 95% CI, 14 to 19).

Preserving Geological Samples and Metadata from Polar Regions

NASA Astrophysics Data System (ADS)

Grunow, A.; Sjunneskog, C. M.

2011-12-01

The Office of Polar Programs at the National Science Foundation (NSF-OPP) has long recognized the value of preserving earth science collections due to the inherent logistical challenges and financial costs of collecting geological samples from Polar Regions. NSF-OPP established two national facilities to make Antarctic geological samples and drill cores openly and freely available for research. The Antarctic Marine Geology Research Facility (AMGRF) at Florida State University was established in 1963 and archives Antarctic marine sediment cores, dredge samples and smear slides along with ship logs. The United States Polar Rock Repository (USPRR) at Ohio State University was established in 2003 and archives polar rock samples, marine dredges, unconsolidated materials and terrestrial cores, along with associated materials such as field notes, maps, raw analytical data, paleomagnetic cores, thin sections, microfossil mounts, microslides and residues. The existence of the AMGRF and USPRR helps to minimize redundant sample collecting, lessen the environmental impact of doing polar field work, facilitates field logistics planning and complies with the data sharing requirement of the Antarctic Treaty. USPRR acquires collections through donations from institutions and scientists and then makes these samples available as no-cost loans for research, education and museum exhibits. The AMGRF acquires sediment cores from US based and international collaboration drilling projects in Antarctica. Destructive research techniques are allowed on the loaned samples and loan requests are accepted from any accredited scientific institution in the world. Currently, the USPRR has more than 22,000 cataloged rock samples available to scientists from around the world. All cataloged samples are relabeled with a USPRR number, weighed, photographed and measured for magnetic susceptibility. Many aspects of the sample metadata are included in the database, e.g. geographical location, sample description, collector, rock age, formation, section location, multimedia images as well structural data, field observations, logistics, surface features, etc. The metadata are entered into a commercial, museum based database called EMu. The AMGRF houses more than 25,000m of deep-sea cores and drill cores as well as nearly 3,000 meters of rotary cored geological material from Antarctica. Detailed information on the sediment cores including location, sediment composition are available in cruise reports posted on the AMGRF web-site. Researchers may access the sample collections through the online websites (http://www-bprc.mps.ohio-state.edu/emuwebusprr and http://www.arf.fsu.edu). Searches may be done using multiple search terms or by use of the mapping feature. The on-line databases provide an essential resource for proposal preparation, pilot studies and other sample based research that should make fieldwork more efficient.

Thermoactivated persulfate oxidation of pesticide chlorpyrifos in aquatic system: kinetic and mechanistic investigations.

PubMed

Zhou, Lei; Zhang, Ya; Ying, Rongrong; Wang, Guoqing; Long, Tao; Li, Jianhua; Lin, Yusuo

2017-04-01

The widespread occurrence of organophosphorus pesticides (OPPs) in the environment poses risks to both ecologic system as well as human health. This study investigated the oxidation kinetics of chlorpyrifos (CP), one of the typical OPPs, by thermoactivated persulfate (PS) oxidation process, and evaluated the influence of key kinetic factors, such as PS concentrations, pH, temperature, bicarbonate, and chloride ions. The reaction pathways and mechanisms were also proposed based on products identification by LC-MS techniques. Our results revealed that increasing initial PS concentration and temperature favored the decomposition of CP, whereas the oxidation efficiency was not affected by pH change ranging from 3 to 11. Bicarbonate was found to play a detrimental role on CP removal rates, while chloride showed no effect. The oxidation pathways including initial oxidation of P=S bond to P=O, dechlorination, dealkylation, and the dechlorination-hydroxylation were proposed, and the detailed underlying mechanisms were also discussed. Molecular orbital (MO) calculations indicated that P=S bond was the most favored oxidation site of the molecule. The toxicity of reaction solution was believed to increase due to the formation of products with P=O structures. This work demonstrates that OPPs can readily react with SO 4 ·- and provides important information for further research on the oxidation of these contaminants.

The Controlled Ecological Life Support System Antarctic Analog Project: Prototype Crop Production and Water Treatment System Performance

NASA Technical Reports Server (NTRS)

Bubenheim, David L.; Flynn, Michael T.; Bates, Maynard; Schlick, Greg; Kliss, Mark (Technical Monitor)

1997-01-01

The Controlled Ecological Life Support System (CELSS) Antarctic Analog Project (CAAP), is a joint endeavor between the National Science Foundation, Office of Polar Programs (NSF-OPP) and the NASA. The fundamental objective is to develop, deploy, and operate a testbed of advanced life support technologies at the Amundsen-Scott South Pole Station that enable the objectives of both the NSF and NASA. The functions of food production, water purification, and waste treatment, recycle and reduction provided by CAAP will improve the quality of life for the South Pole inhabitants, reduce logistics dependence, enhance safety and minimize environmental impacts associated with human presence on the polar plateau. Because of the analogous technical, scientific, and mission features with Planetary missions such as a mission to Mars, CAAP provides NASA with a method for validating technologies and overall approaches to supporting humans. Prototype systems for sewage treatment, water recycle and crop production are being evaluated at Ames Research Center. The product water from sewage treatment using a Wiped-Film Rotating Disk is suitable for input to the crop production system. The crop production system has provided an enhanced level of performance compared with projected performance for plant-based life support: an approximate 50% increase in productivity per unit area, more than a 65% decrease in power for plant lighting, and more than a 75% decrease in the total power requirement to produce an equivalent mass of edible biomass.

The effect of β-saturated pyrrolic rings on the electronic structures and aromaticity of magnesium porphyrin derivatives: a density functional study.

PubMed

Wan, Liang; Qi, Dongdong; Zhang, Yuexing

2011-09-01

Density functional theory (DFT) calculation on the molecular structures, molecular orbitals, electronic absorption spectra, and magnetic properties of magnesium porphyrin (MgPor) and a series of five hydrogenated magnesium porphyrin complexes with different number of β-saturated pyrrolic rings, namely MgPor-β-1Hy, MgPor-β-opp-2Hy, MgPor-β-adj-2Hy, MgPor-β-3Hy, and MgPor-β-4Hy, clarifies the red-shift of the lowest energy absorption band from chlorophyll a to bacteriochlorophyll and reveals the strong chemical stability for both of them. The energy levels of highest occupied molecular orbitals (HOMO) and HOMO-1 for MgPor are reversed upon hydrogenation at β-positions (2 and 3, 7 and 8, 12 and 13, and 17 and 18) of porphyrin ring. Along with the increase of β-saturated pyrrolic rings from 1, 2, 3, to 4, the HOMO energy increases from -4.78 eV to -3.10 eV in a regular manner. In contrast, the lowest unoccupied molecular orbitals (LUMO) energy levels of MgPor, MgPor-β-1Hy, and MgPor-β-opp-2Hy are very similar with each other. As a result, the lowest energy absorption band involving main transition from HOMO to LUMO is red-shifted from MgPor-β-1Hy to MgPor-β-opp-2Hy which is representative of chlorophyll a and bacteriochlorophyll, respectively. Natural hydroporphyrins represented by MgPor, MgPor-β-1Hy, and MgPor-β-opp-2Hy have turned out to be aromatic and stable enough, in good accordance with the ubiquity of their derivatives in the nature. In contrast, MgPor-β-adj-2Hy, MgPor-β-3Hy, and MgPor-β-4Hy with relatively weak aromaticity seem to be unstable and therefore were not found in nature. Copyright © 2011 Elsevier Inc. All rights reserved.

Liquid waveguide spectrophotometric measurement of nanomolar ammonium in seawater based on the indophenol reaction with o-phenylphenol (OPP).

PubMed

Hashihama, Fuminori; Kanda, Jota; Tauchi, Ami; Kodama, Taketoshi; Saito, Hiroaki; Furuya, Ken

2015-10-01

We describe a highly sensitive colorimetric method for the determination of nanomolar concentrations of ammonium in seawater based on the indophenol reaction with o-phenylphenol [(1,1'-biphenyl)-2-ol, abbreviated as OPP]. OPP is available as non-toxic, stable flaky crystals with no caustic odor and has some advantages over phenol in practical use. The method was established by using a gas-segmented continuous flow analyzer equipped with two types of long path liquid waveguide capillary cell, LWCCs (100 cm and 200 cm) and an UltraPath (200 cm), which have inner diameters of 0.55 mm and 2 mm, respectively. The reagent concentrations, flow rates of the pumping tubes, and reaction path and temperature were determined on the basis of a manual indophenol blue method with OPP (Kanda, Water Res. 29 (1995) 2746-2750). The sample mixed with reagents that form indophenol blue dye was measured at 670 nm. Aged subtropical surface water was used as a blank, a matrix of standards, and the carrier. The detection limits of the analytical systems with a 100 cm LWCC, a 200 cm LWCC, and a 200 cm UltraPath were 6, 4, and 4 nM, respectively. These systems had high precision (<4% at 100 nM) and a linear dynamic range up to 200 nM. Non-linear baseline drift did not occur when using the UltraPath system. This is due to the elimination of cell clogging because of the larger inner diameter of the UltraPath compared to the LWCCs. The UltraPath system is thus more suitable for long-term measurements compared with the LWCC systems. The results of the proposed sensitive colorimetry and a conventional colorimetry for the determination of seawater samples showed no significant difference. The proposed analytical systems were applied to underway surface monitoring and vertical observation in the oligotrophic South Pacific. Copyright © 2015 Elsevier B.V. All rights reserved.

Biodegradation and bioremediation potential of diazinon-degrading Serratia marcescens to remove other organophosphorus pesticides from soils.

PubMed

Cycoń, Mariusz; Żmijowska, Agnieszka; Wójcik, Marcin; Piotrowska-Seget, Zofia

2013-03-15

The ability of diazinon-degrading Serratia marcescens to remove organophosphorus pesticides (OPPs), i.e. chlorpyrifos (CP), fenitrothion (FT), and parathion (PT) was studied in a mineral salt medium (MSM) and in three soils of different characteristics. This strain was capable of using all insecticides at concentration of 50 mg/l as the only carbon source when grown in MSM, and 58.9%, 70.5%, and 82.5% of the initial dosage of CP, FT, and PT, respectively was degraded within 14 days. The biodegradation experiment showed that autochthonous microflora in all soils was characterized by a degradation potential of all tested OPPs; however, the initial lag phases for degradation of CP and FT, especially in sandy soil, were observed. During the 42-day experiment, 45.3%, 61.4% and 72.5% of the initial dose of CP, FT, and PT, respectively, was removed in sandy soil whereas the degradation of CP, FT, and PT in the same period, in sandy loam and silty soils reached 61.4%, 79.7% and 64.2%, and 68.9%, 81.0% and 63.6%, respectively. S. marcescens introduced into sterile soils showed a higher degradation potential (5-13%) for OPPs removal than those observed in non-sterile soil with naturally occurring attenuation. Inoculation of non-sterile soils with S. marcescens enhanced the disappearance rates of all insecticides, and DT50 for CP, FT, and PT was reduced by 20.7, 11.3 and 13.0 days, and 11.9, 7.0 and 8.1 days, and 9.7, 14.5 and 12.6 days in sandy, sandy loam, and silty soils, respectively, in comparison with non-sterile soils with only indigenous microflora. This ability of S. marcescens makes it a suitable strain for bioremediation of soils contaminated with OPPs. Copyright © 2013 Elsevier Ltd. All rights reserved.

[In vivo measurement of ocular circulation with the laser speckle method--development of apparatus and application in ophthalmological research].

PubMed

Araie, M

1999-12-01

We have developed an apparatus utilizing laser speckle phenomenon which can measure the peripheral circulation in the iris, choroid, retina and optic nerve head (ONH) and blood velocity through retinal vessels in the living eye non-invasively and quantitatively. A blue-component argon laser (wavelength 488 nm) was used for measurement of peripheral circulation in the retina and a diode laser (wavelength 808 nm) for measurements of peripheral circulation in the iris, posterior choroid and ONH, and measurement of centerline blood velocity through retinal vessels. A fundus camera (TRC-WT 3, Topcon) was equipped with a laser source and an image sensor where the speckle pattern from the fundus appears, and the data were analyzed with a personal computer to give a normalized blur (NB) value or a square blur rate (SBR) value, both quantitative indices of blood velocity. The NB value, whose computation requires much less time, was adopted to evaluate peripheral circulation because of non-linear correlation between the NB and actual blood velocity in the range above 20 mm/sec. The SBR value, whose computation requires a longer time, was adopted for measurement of blood velocity through retinal vessels. Measurement field in the living eye was 1.06 x 1.06 mm at its maximum and reproducibility index of the in vivo measurement in the rabbit iris, choroid, retina, and ONH was approximately 10%. When blood flow was changed by intraocular pressure (IOP) change in rabbit eyes, NB values obtained from the iris, choroid, and retina showed a significant correlation with the blood flow simultaneously determined with the colored microsphere technique in the same eye, and the NB obtained from the ONH also correlated with the blood flow determined with the H2 gas clearance method. Stepwise reduction in the ocular perfusion pressure (OPP) by stepwise increment of IOP resulted in proportional reduction in the iris- and choroid-NB. On the other hand, the retina- or ONH-NB remained almost unaltered at OPP levels above 50 mmHg, and decreased along with OPP at levels less than 50 mmHg. By monitoring NB values for 2 hours, presence or absence of autoregulatory mechanism against OPP change in the choroidal and ONH circulation was studied in rabbits. Throughout the experimental period of 2 hours, the choroidal NB was changed along with the OPP change, suggesting absence of blood flow autoregulation in this tissue. In the ONH, however, the NB returned to the baseline after its transient increase or decrease when the OPP was continuously increased or decreased, showing the presence of an autoregulatory mechanism in the ONH circulation. However, the time course of the NB resumption depended on the extent of OPP change. These results indicated that the laser speckle method can be useful in investigating the autoregulatory mechanism and processes of peripheral circulation in ocular tissues. Unilateral instillation of drugs with vasodilative activity (ifenprodil, betaxolol or nipradilol) in rabbit eyes significantly increased ONH and/or choroidal circulation. The extent in change in the ONH and/or choroidal circulation correlated with the number of doses, but not with the extent of IOP reduction, which suggested that the observed effects were attributable to the drug which penetrated locally. Intravenous administration of a Ca(2+)-antagonist (nicardipine, nilvadipine or pranidipine) significantly increased choroidal or retinal circulation in rabbits. The ONH circulation, however, was not affected by nicardipine, but affected by nilvadipine or pranidipine. Given the same effect on the ONH circulation, systemic hypotensive effect was stronger in pranidipine than in nilvadipine, which suggested that nilvadipine can be used in patients with ocular circulatory insufficiency. A modification of the laser speckle apparatus used for animal experiments was devised so that the NB or SBR values could be measured in human eyes every 0.12 sec on a real-time basis. (ABSTRACT TRUN

Sonographic evaluation of the fetal spine position and success rate of manual rotation of the fetus in occiput posterior position: A randomized controlled trial.

PubMed

Masturzo, Bianca; Farina, Antonio; Attamante, Lorenza; Piazzese, Annalisa; Rolfo, Alessandro; Gaglioti, Pietro; Todros, Tullia

2017-10-01

To evaluate whether sonographic (US) diagnosis of the fetal spine position could increase the success rate of manual rotation of the fetal occiput (MRFO) in second-stage arrest in persistent occiput posterior position (OPP). In this randomized controlled parallel single-center trial, 58 nulliparous in second-stage arrest of labor with fetus in cephalic presentation and OPP diagnosed by US were randomly assigned to group A where the fetal spine position was not known by the operator or to group B where the operator knew it. The main outcome was the success of MRFO in the two groups. Secondary outcomes were perineal injuries, blood loss, duration of expulsive period, and neonatal APGAR at 5 minutes. A priori knowledge of the spine position improves the success of the MRFO (41.4% group A versus 82.8% group B, p value < 0.001), the percentage of spontaneous deliveries (27.6% group A versus 69% group B, p value = 0.01), and maternal outcome (intact perineum and blood loss). No differences were detected on the neonatal side. MRFO is a safe and useful procedure that should be performed in second-stage arrest in OPP. A better performance was observed when supported by the US knowledge of the spine position. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:472-476, 2017. © 2017 Wiley Periodicals, Inc.

Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.

PubMed

Steinritz, Dirk; Eyer, Florian; Worek, Franz; Thiermann, Horst; John, Harald

2016-02-26

Accidental self-poisoning or deliberate use in suicidal intent of organophosphorus pesticides (OPP), which are widely used in agriculture, represent a health problem worldwide. Symptoms of poisoning are characterized by acute cholinergic crisis caused by inhibition of acetylcholinesterase. A 75-year-old male patient ingested 20ml of an OPP solution containing 10% methamidophos in suicidal intent. In the course of poisoning typical clinical symptoms of cholinergic crisis (miosis, bradycardia, hypotension, hypersalivation and impairment of neurologic status) were evident. Butyryl (plasma) cholinesterase (BChE) and red blood cell acetylcholinesterase (RBC-AChE) revealed decreased activities, thus specific treatment with the enzyme reactivator obidoxime was started. Inhibitory activity of the patient's plasma indicated significant amounts of persisting methamidophos in the circulation and was still found on day 4 after ingestion. Due to missing spontaneous breathing on day 6, obidoxime was administered again. Afterwards a significant increase of RBC-AChE activity was found. The patient was extubated on day 10 and a restitution ad integrum was achieved. In conclusion, obidoxime is a potent reactivator of OPP-inhibited AChE. A repetitive and prolonged administration of obidoxime should be considered in cases of severe methamidophos poisoning and should be tailored with an advanced analytical biomonitoring. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Coprecipitation-assisted coacervative extraction coupled to high-performance liquid chromatography: An approach for determining organophosphorus pesticides in water samples.

PubMed

Mammana, Sabrina B; Berton, Paula; Camargo, Alejandra B; Lascalea, Gustavo E; Altamirano, Jorgelina C

2017-05-01

An analytical methodology based on coprecipitation-assisted coacervative extraction coupled to HPLC-UV was developed for determination of five organophosphorus pesticides (OPPs), including fenitrothion, guthion, parathion, methidathion, and chlorpyrifos, in water samples. It involves a green technique leading to an efficient and simple analytical methodology suitable for high-throughput analysis. Relevant physicochemical variables were studied and optimized on the analytical response of each OPP. Under optimized conditions, the resulting methodology was as follows: an aliquot of 9 mL of water sample was placed into a centrifuge tube and 0.5 mL sodium citrate 0.1 M, pH 4; 0.08 mL Al 2 (SO 4 ) 3 0.1 M; and 0.7 mL SDS 0.1 M were added and homogenized. After centrifugation the supernatant was discarded. A 700 μL aliquot of the coacervate-rich phase obtained was dissolved with 300 μL of methanol and 20 μL of the resulting solution was analyzed by HPLC-UV. The resulting LODs ranged within 0.7-2.5 ng/mL and the achieved RSD and recovery values were <8% (n = 3) and >81%, respectively. The proposed analytical methodology was successfully applied for the analysis of five OPPs in water samples for human consumption of different locations of Mendoza. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Analysis of eight organophosphorus pesticide residues in fresh vegetables retailed in agricultural product markets of Nanjing, China.

PubMed

Wang, Ligang; Liang, Yongchao; Jiang, Xin

2008-10-01

A method to effectively remove pigments in fresh vegetables using activated carbon followed cleanup through solid phase extraction (SPE) cartridge to further reduce matrix interference and contamination, was established to determine eight organophosphorous pesticides (OPPs) by gas chromatography (GC) with nitrogen-phosphorus detection (NPD) in this study, and it has been successfully applied for the determination of eight OPPs in various fresh vegetables with the recoveries ranging from 61.8% to 107%. To evaluate eight OPPs residue level, some fresh vegetables retailed at three agricultural product markets (APM) of Nanjing in China were detected, the results showed that phorate in Shanghai green (0.0257 microg g(-1)) and Chinese cabbage (0.0398 microg g(-1)), dimethoate in Shanghai green (0.0466-0.0810 microg g(-1)), Chinese cabbage (0.077 microg g(-1)), and spinach (0.118-0.124 microg g(-1)), methyl-parathion in Shanghai green (0.0903 microg g(-1)), Chinese cabbage (0.157 microg g(-1)), and spinach (0.0924 microg g(-1)), malathion in Shanghai green (0.0342-0.0526 microg g(-1)), chorpyrifos in spinach (0.106-0.204 microg g(-1)), and Chinese cabbage (0.149 microg g(-1)), chlorfenvinfos in carrot (0.094-0.131 microg g(-1)), were found. However, fonofos and fenthion were not detected in all the collected vegetable samples.

Role of NO in choroidal blood flow regulation during isometric exercise in healthy humans.

PubMed

Luksch, Alexandra; Polska, Elzbieta; Imhof, Andrea; Schering, Joanne; Fuchsjäger-Mayrl, Gabriele; Wolzt, Michael; Schmetterer, Leopold

2003-02-01

Nitric oxide (NO) is an important regulator of basal choroidal blood flow. Animal experiments indicate that NO is also involved in choroidal blood flow regulation during changes in ocular perfusion pressure and inhibition of NO synthase (NOS) has been reported to shift choroidal pressure-flow curves to the right. The hypothesis for the study was that inhibition of NOS may influence choroidal blood flow during isometric exercise. To test this hypothesis, a randomized, double-masked, placebo-controlled, three-way crossover study was performed in 12 healthy male volunteers. Subjects received on different study days intravenous infusions of N(G)-monomethyl-L-arginine (L-NMMA), phenylephrine, or placebo. During these infusion periods, subjects were asked to squat for 6 minutes. Choroidal blood flow was assessed with laser Doppler flowmetry, and ocular perfusion pressure (OPP) was calculated from mean arterial pressure and intraocular pressure. L-NMMA and phenylephrine increased resting OPP by 10% and 13%, respectively, but only L-NMMA reduced resting choroidal blood flow (-17%, P < 0.001). The relative increase in OPP during isometric exercise was comparable with all drugs administered. Isometric exercise increased choroidal blood flow during administration of placebo and phenylephrine, but not during administration of L-NMMA (P < 0.001 vs. placebo). These data indicate that NO plays an important role in the regulation of choroidal blood flow during isometric exercise.

Choroidal hemodynamic changes during isometric exercise in patients with inactive central serous chorioretinopathy.

PubMed

Tittl, Michael; Maar, Noemi; Polska, Elzbieta; Weigert, Günther; Stur, Michael; Schmetterer, Leopold

2005-12-01

Imaging studies suggest that the choroidal vasculature may be altered in central serous chorioretinopathy. Little is known, however, about the regulation of ocular blood flow in patients with central serous chorioretinopathy (CSC). The hypothesis for the present study was that choroidal blood flow changes during an increase in ocular perfusion pressure induced by isometric exercise may be altered in CSC. An observer-masked, two-cohort study was performed in 14 nonsmoking patients with chronic-relapsing but inactive CSC and in 14 healthy nonsmoking volunteers. Both groups were matched for age and sex. Subfoveal choroidal blood flow (CBF) was assessed with laser Doppler flowmetry, and ocular perfusion pressure (OPP) was calculated from mean arterial pressure (MAP) and intraocular pressure (IOP). Changes of CBF during isometric exercise over a period of 6 minutes were measured. Whereas the increase of MAP, the pulse rate, and the OPP were comparable between the two study groups, subfoveal CBF increased significantly more in the group of patients with CSC (P < 0.001). IOP remained unchanged in both groups during isometric exercise. At an 85% increase in OPP, subfoveal CBF was approximately twice as high in the patients with CSC compared with the healthy control group. The data indicate an abnormal subfoveal CBF regulation in patients with relapsing CSC compared with age-matched, nonsmoking, healthy volunteers during isometric exercise.

Development of TiO2 powder-coated food packaging film and its ability to inactivate Escherichia coli in vitro and in actual tests.

PubMed

Chawengkijwanich, Chamorn; Hayata, Yasuyoshi

2008-04-30

Titanium dioxide (TiO2) has attracted a great deal of attention as a photocatalytic disinfecting material in the food and environmental industry. TiO2 has been used to inactivate a wide variety of microorganisms in many applications. In the present study, we aimed to develop a TiO2 powder-coated packaging film and clarify its ability to inactivate Escherichia coli both in vitro and in actual tests, using two different particle sizes and two types of illumination at different intensities. No inhibition effect of the testing method itself on the growth of E. coli was observed. The cells of E. coli were found to have decreased 3 log CFU/ml after 180 min of illumination by two 20 W black-light bulbs (wavelength of 300-400 nm) on TiO2-coated oriented-polypropylene (OPP) film, while E. coli decreased 1 log CFU/m with black-light illumination of uncoated OPP film. The results showed that both ultraviolet A (UVA; wavelength of 315-400 nm) alone and TiO2-coated OPP film combined with UVA reduced the number of E. coli cell in vitro, but that the reduction of E. coli cell numbers was greater by TiO2-coated OPP film combined with UVA. The antimicrobial effect of TiO2-coated film is dependent on the UVA light intensity (0, <0.05 and 1 mW/cm2) and the kind of artificial light (black-light and daylight fluorescent bulbs), but it is independent of the particle size of TiO2 coating on the surface of OPP film. The surviving cell numbers of E. coli on TiO2-coated film decreased 3 log and 0.35 log CFU/ml after 180 min of illumination by two 20 W black bulbs and two 20 W daylight fluorescent bulbs, respectively. Despite the lesser efficacy of the photocatalytic method with fluorescent lights, the survival of E. coli cells using this method was 50% of that using fluorescent lights alone. In the actual test, the number of E. coli cells from cut lettuce stored in a TiO2-coated film bag irradiated with UVA light decreased from 6.4 on Day 0 to 4.9 log CFU/g on Day 1, while that of an uncoated film bag irradiated with UVA light decreased from 6.4 to 6.1 log CFU/g after 1 day of storage. The result shows that the TiO2-coated film could reduce the microbial contamination on the surface of solid food products and thus reduce the risks of microbial growth on fresh-cut produce.

Pesticide Registration Information System

EPA Pesticide Factsheets

PRISM provides an integrated, web portal for all pesticide related data, communications, registrations and transactions for OPP and its stakeholders, partners and customers. PRISM supports Strategic Goal 4 by automating pesticide registration processes.

Food and Feed Commodity Vocabulary

EPA Pesticide Factsheets

Food and Feed Vocabulary was developed to consolidate all the major OPP Commodity Vocabularies into one standardized vocabulary. The EPA-preferred term is the only term that can be used in setting tolerances.

75 FR 26754 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... Use/Terrestrial Non- food Crops: Landscape ornamentals and turf grass (including sod farms) and...) and turf grass (including sod farms) Docket ID Number: EPA-HQ-OPP-2010-0349. New Active Ingredient...

Investigation of a Modern Incipient Stromatolite from Obsidian Pool Prime, Yellowstone National Park: Implications for Early Lithification in the Formation of Light-Dark Stromatolite Laminae

NASA Astrophysics Data System (ADS)

Corsetti, F. A.; Berelson, W.; Pepe-Ranney, C. P.; Mata, S. A.; Spear, J. R.

2016-12-01

Stromatolites have been defined multiple ways, but the presence of lamination is common to all definitions. Despite this commonality, the origin of the lamination in many ancient stromatolites remains vague. Lamination styles vary, but sub-mm light-dark couplets are common in many ancient stromatolites. Here, we investigate an actively forming incipient stromatolite from Obsidian Pool Prime (OPP), a hot spring in Yellowstone National Park, to better understand the formation of light-dark couplets similar to many ancient stromatolites in texture and structure. In the OPP stromatolites, a dense network of layer-parallel bundles of cyanobacterial filaments (a dark layer) is followed by an open network of layer-perpendicular or random filaments (a light layer) that reflect a diurnal cycle in the leading edge of the microbial mat that coats the stromatolite's surface. Silica crust encases the cyanobacterial filaments maintaining the integrity of the lamination. Bubbles formed via oxygenic photosynthesis are commonly trapped within the light layers, indicating that lithification occurs rapidly before the bubbles can collapse. The filamentous, non-heterocystous stromatoite-building cyanobacterium from OPP is most closely related to a stromatolite-building cyanobacterium from a hot spring in Japan. Once built, "tenants" from multiple microbial phyla move into the structure, mixing and mingling to produce a complicated integrated biogeochemical signal that may be difficult to untangle in ancient examples. While the cyanobacterial response to the diurnal cycle has been previously implicated in the formation of light-dark couplets, the OPP example highlights the importance of early lithification in maintaining the fabric. Thus, the presence of light-dark couplets and bubble structures may indicate very early lithification and therefore a certain degree of mineral saturation in the ancient ocean or other aquatic system, and that bubble structures, if present, may be evidence for oxygenic photosynthesis. Other lamination hypotheses suggest that lithification is driven by sulfate reduction within a stratified microbial mat—a possibility in some stromatolites, but the lithification engine must move deeper in the mat where the formation of fine light-dark couplets becomes more problematic.

On the sighted ancestry of blindness - exceptionally preserved eyes of Mesozoic polychelidan lobsters.

PubMed

Audo, Denis; Haug, Joachim T; Haug, Carolin; Charbonnier, Sylvain; Schweigert, Günter; Müller, Carsten H G; Harzsch, Steffen

2016-01-01

Modern representatives of Polychelida (Polychelidae) are considered to be entirely blind and have largely reduced eyes, possibly as an adaptation to deep-sea environments. Fossil species of Polychelida, however, appear to have well-developed compound eyes preserved as anterior bulges with distinct sculpturation. We documented the shapes and sizes of eyes and ommatidia based upon exceptionally preserved fossil polychelidans from Binton (Hettangian, United-Kingdom), Osteno (Sinemurian, Italy), Posidonia Shale (Toarcian, Germany), La Voulte-sur-Rhône (Callovian, France), and Solnhofen-type plattenkalks (Kimmeridgian-Tithonian, Germany). For purposes of comparison, sizes of the eyes of several other polychelidans without preserved ommatidia were documented. Sizes of ommatidia and eyes were statistically compared against carapace length, taxonomic group, and outcrop. Nine species possess eyes with square facets; Rosenfeldia oppeli (Woodward, 1866), however, displays hexagonal facets. The sizes of eyes and ommatidia are a function of carapace length. No significant differences were discerned between polychelidans from different outcrops; Eryonidae, however, have significantly smaller eyes than other groups. Fossil eyes bearing square facets are similar to the reflective superposition eyes found in many extant decapods. As such, they are the earliest example of superposition eyes. As reflective superposition is considered plesiomorphic for Reptantia, this optic type was probably retained in Polychelida. The two smallest specimens, a Palaeopentacheles roettenbacheri (Münster, 1839) and a Hellerocaris falloti (Van Straelen, 1923), are interpreted as juveniles. Both possess square-shaped facets, a typical post-larval feature. The eye morphology of these small specimens, which are far smaller than many extant eryoneicus larvae, suggests that Jurassic polychelidans did not develop via giant eryoneicus larvae. In contrast, another species we examined, Rosenfeldia oppeli (Woodward, 1866), did not possess square-shaped facets, but rather hexagonal ones, which suggests that this species did not possess reflective superposition eyes. The hexagonal facets may indicate either another type of superposition eye (refractive or parabolic superposition), or an apposition eye. As decapod larvae possess apposition eyes with hexagonal facets, it is most parsimonious to consider eyes of R. oppeli as apposition eyes evolved through paedomorphic heterochrony. Polychelidan probably originally had reflective superposition. R. oppeli, however, probably gained apposition eyes through paedomorphosis.

75 FR 10259 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer..., 70127-8, 70127-10. Docket Number: EPA-HQ-OPP-2010-0081. Company Name and Address: Novozymes Biologicals...

Tests of potential functional barriers for laminated multilayer food packages. Part II: Medium molecular weight permeants.

PubMed

Simal-Gándara, J; Sarria-Vidal, M; Rijk, R

2000-09-01

Experiments were performed to characterize the kinetics of the permeation of different medium molecular weight model permeants: bisphenol A, warfarin and anthracene, from liquid paraffin, through a surrogate potential functional barrier (25 microns-thick orientated polypropylene--OPP) into the food simulants olive oil and 3% (w/v) acetic acid. The characterization of permeation kinetics generally observed the permeation models previously reported to explain the experimental permeation results obtained for a low molecular weight group of model permeants. In general, the model permeants exhibited behaviour consistent with their relative molecular weights with respect to (a) the time taken to attain steady-state permeation into the food simulant in which they were more soluble, (b) their subsequent steady-state permeation rates, and (c) their partition between liquid paraffin and the OPP membrane.

Organophosphorus pesticides effect on early stages of the axolotl Ambystoma mexicanum (Amphibia: Caudata).

PubMed

Robles-Mendoza, C; García-Basilio, C; Cram-Heydrich, S; Hernández-Quiroz, M; Vanegas-Pérez, C

2009-02-01

Ambystoma mexicanum is an endemic salamander of Xochimilco, a wetland of the basin of Mexico valley. Nowadays, axolotl populations are decreasing due environmental stressors. Particularly, studies about organophosphorus pesticides (OPPs; i.e. chlorpyrifos and malathion) toxicity are of great importance due to their intensive use in agricultural activities in Xochimilco. Thus, the aim of this study was to evaluate under controlled conditions the toxicity of chlorpyrifos (CPF) and malathion (MLT) on embryos and larvae (stage 44 and 54) of A. mexicanum. Embryos and larvae were exposure 96h from 0.5 to 3mg CPFL(-1) and from 10 to 30mg MLTL(-1) in independent tests. Embryos at the end of this period were maintained 9d without pesticide in order to identify possible recuperation. Differences obtained in mortality, hatching success, development, morphological abnormalities, behaviour and activity, suggest that toxicity of CPF and MLT differs in embryos and larval stages. Embryos were less sensitive to OPPs acute exposure than axolotl larvae; additionally, toxicity of CPF in larval stages was greater than MLT. On the other hand, data obtained in axolotl embryos during the period of recuperation to CPF in particular as delay and inhibition of development, malformations and success of hatching, indicated that these responses turned out more sensitive than mortality. This study allowed to identify the toxicological potential of OPPs on early developmental stages of A. mexicanum and it is a valuable contribution for the future management of the axolotl wild population.

Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate.

PubMed

Costa, Ana Paula Araujo; Lima, Aline Maria Vasconcelos; da Silva, Luiz Henrique; de Oliveira Alves Carvalho, Rosângela; do Amaral, Andréia Vitor Couto; Borges, Naida Cristina

2016-07-22

It has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of the external ophthalmic artery measured prior to treatment and on days one (moment M1), seven (when M2), fourteen (moment M3), twenty-one (moment M4), and thirty (moment M5) of treatment. The MAP and OPP values of treated group were lower than those of control group at all times, and the mean values differed statistically at moments M1 (S = 71.52 mmHg, C = 84.76 mmHg, p = 0.0356) and M5 (S = 71.38 mmHg, C = 85.52 mmHg, p = 0.0252). The IOP and color Doppler values of the external ophthalmic artery did not differ between tested groups. The dose of 10 mg of sildenafil citrate administered to healthy rabbits causes systemic vasodilation and consequently lower values of MAP and OPP. However, it does not induce changes in IOP and retrobulbar hemodynamics identifiable by color Doppler assessment of the external ophthalmic artery.

Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface.

PubMed

Liu, Chang; Gómez-Ríos, Germán Augusto; Schneider, Bradley B; Le Blanc, J C Yves; Reyes-Garcés, Nathaly; Arnold, Don W; Covey, Thomas R; Pawliszyn, Janusz

2017-10-23

Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed figures of merit. However, in most cases, such processes are not optimal for urgent assessments and high-throughput determinations. The direct coupling of solid phase microextraction (SPME) to MS has shown great potential to shorten the total sample analysis time of complex matrices, as well as to diminish potential matrix effects and instrument contamination. In this study, we demonstrate the use of the open-port probe (OPP) as a direct and robust sampling interface to couple biocompatible-SPME (Bio-SPME) fibres to MS for the rapid quantitation of opioid isomers (i.e. codeine and hydrocodone) in human plasma. In place of chromatography, a differential mobility spectrometry (DMS) device was implemented to provide the essential selectivity required to quantify these constitutional isomers. Taking advantage of the simplified sample preparation process based on Bio-SPME and the fast separation with DMS-MS coupling via OPP, a high-throughput assay (10-15 s per sample) with limits of detection in the sub-ng/mL range was developed. Succinctly, we demonstrated that by tuning adequate ion mobility separation conditions, SPME-OPP-MS can be employed to quantify non-resolved compounds or those otherwise hindered by co-extracted isobaric interferences without further need of coupling to other separation platforms. Copyright © 2017 Elsevier B.V. All rights reserved.

Researcher Story: Stuttering

MedlinePlus Videos and Cool Tools

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78 FR 40737 - Issuance of Two Experimental Use Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

.... SUMMARY: EPA has granted experimental use permits (EUPs) to the following pesticide applicants: Stephen L... has issued the following EUPs: 1. 88877-EUP-1. (EPA-HQ-OPP-2012-0181). Issuance. Stephen L. Dobson...

Field Results for an Arctic AUV Designed for Characterizing Circulation and Ice Thickness

NASA Astrophysics Data System (ADS)

Bellingham, J. G.; Kirkwood, W. J.; Tervalon, N.; Cokelet, E.; Thomas, H.; Sibenac, M.; Gashler, D.; McEwen, R.; Henthorn, R.; Shane, F.; Osborn, D. J.; Johnson, K.; Overland, J.; Stein, P.; Bahlavouni, A.; Anderson, D.

2002-12-01

An Autonomous Underwater Vehicle designed for operation at high latitudes and under ice completed its first Arctic field tests from the USCGC Healy in fall of 2001. The ALTEX AUV has been under development since 1998, and is being created to provide: unprecedented endurance, ability to navigate at high latitudes, a depth rating of 1500 to 4500 meters depending on payload, and the capability to relay data through the ice to satellites via data buoys. The AUV's initial applications are focused on tracking the warm Atlantic Layer inflow - the primary source of seawater to the Arctic Ocean. Consequently the primary payloads are twin pumped CTD systems. Oxygen and nitrate sensors provide the ability to use NO as a tracer. An ice profiling sonar allows the AUV to estimate the ice thickness in real-time and is designed to generate high quality post-processed ice draft data comparable to that collected through the SCICEX program. The experiments in October aboard the USCGC Healy generated numerous water column and under-ice data sets. Traditional ship-based CTD operations were used to provide a comparison data set for AUV water column measurements. The post-processed ice draft results show reasonable ice profiles and have the potential, when combined with other science data collected, to shed some additional light on upper water column processes in ice-covered regions. Cruise results include: operating the AUV from the USCGC Healy in the ice pack, demonstrating inertial navigation system performance, obtaining oceanographic sections with the AUV, obtaining ice draft measurements with an AUV born sonar, and testing the data-buoy system. This work is supported by the National Science Foundation under grant NSF-OPP 9910290. The Packard Foundation and the Office of Naval Research have also provided support. The project was initiated under the National Ocean Partnership Program under contract N00014-98-1-0814.

2. Historic American Buildings Survey Branan Sanders, Photographer March 1934 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Branan Sanders, Photographer March 1934 FRONT This picture also reproduce in 'Garden History of Georgia', opp. p. 1. - Santo Domingo Mission (Ruins), Near Altamaha Canal (River), Broadfield, Glynn County, GA

Strategic Vision for Adopting 21st Century Science Methodologies

EPA Pesticide Factsheets

To better protect human health and the environment, EPA’s OPP is developing and evaluating new technologies in molecular, cellular, computational sciences to supplement or replace more traditional methods of toxicity testing and risk assessment.

6. Historic American Buildings Survey Frank O. Branzetti, Photographer July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey Frank O. Branzetti, Photographer July 23, 1940 (b) 7- MILE STONE, opp. 1040 ADAMS ST., DORCHESTER - Milestones A, B, E, HHH, III & PPP, Various Dorchester locations, Dorchester, Suffolk County, MA

75 FR 17987 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... time on an intraday basis at its discretion if it determined that volatility warranted deactivation. Members would be notified of intraday OPP deactivation due to volatility and any subsequent intraday...

Decontamination Technologies for Emerging CBRNE Agents: Scoping Study

DTIC Science & Technology

2014-05-01

organophosphorus pesticides ( chlorpyrifos , diazinon, malathion) which are neurotoxins, and other pesticides (captan, folpet, tralkoxydim, chlorthalonil, 1,3...organophosphorus pesticides (OPPs), gamma radiolysis for chlorpyrifos , and bio-detoxification of pesticides such as diazinon and chlorpyrifos . For instance

2. Historic American Buildings Survey Frank O. Branzetti, Photographer July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Frank O. Branzetti, Photographer July 9, 1940 (ccc) 6- MILE STONE, opp. 487 HANCOCK ST., QUINCY - Milestones H, I, CCC, DDD & EEE, Various Quincy locations, Quincy, Norfolk County, MA

Management of Blood Pressure in Patients with Glaucoma.

PubMed

Levine, Russell M; Yang, Alina; Brahma, Venkatesh; Martone, James F

2017-09-19

Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma and to create a forum of discussion between ophthalmologists and internal medicine specialists. Both high and low BP has been linked glaucoma. Low BP is particularly associated with glaucoma progression in normal-tension glaucoma (NTG) patients. Patients who have low nighttime BP readings are at highest risk of progression of their glaucoma. Internal medicine specialists and ophthalmologists should consider the relationship between BP and glaucoma when treating patients with concomitant disease. Too-low nighttime BP should be avoided. Ambulatory blood pressure monitoring is a useful tool to identify patients at greatest risk for progression.

Fabrication and Characteristics of High Mobility InSnZnO Thin Film Transistors.

PubMed

Choi, Pyungho; Lee, Junki; Park, Hyoungsun; Baek, Dohyun; Lee, Jaehyeong; Yi, Junsin; Kim, Sangsoo; Choi, Byoungdeog

2016-05-01

In this paper, we describe the fabrication of thin film transistors (TFTs) with amorphous indium-tin-zinc-oxide (ITZO) as the active material. A transparent ITZO channel layer was formed under an optimized oxygen partial pressure (OPP (%) = O2/(Ar + O2)) and subsequent annealing process. The electrical properties exhibited by this device include field-effect mobility (μ(eff)), sub-threshold swing (SS), and on/off current ratio (I(ON/OFF)) values of 28.97 cm2/V x s, 0.2 V/decade, and 2.64 x 10(7), respectively. The average transmittance values for each OPP condition in the visible range were greater than 80%. The positive gate bias stress resulted in a positive threshold voltage (V(th)) shift in the transfer curves and degraded the parameters μ(eff) and SS. These phenomena originated from electron trapping from the ITZO channel layer into the oxide/ITZO interface trap sites.

Physically incorporated extraction phase of solid-phase microextraction by sol-gel technology.

PubMed

Liu, Wenmin; Hu, Yuan; Zhao, Jinghong; Xu, Yuan; Guan, Yafeng

2006-01-13

A sol-gel method for the preparation of solid-phase microextraction (SPME) fiber was described and evaluated. The extraction phase of poly(dimethysiloxane) (PDMS) containing 3% vinyl group was physically incorporated into the sol-gel network without chemical bonding. The extraction phase itself is then partly crosslinked at 320 degrees C, forming an independent polymer network and can withstand desorption temperature of 290 degrees C. The headspace extraction of BTX by the fiber SPME was evaluated and the detection limit of o-xylene was down to 0.26 ng/l. Extraction and determination of organophosphorus pesticides (OPPs) in water, orange juice and red wine by the SPME-GC thermionic specified detector (TSD) was validated. Limits of detection of the method for OPPs were below 10 ng/l except methidathion. Relative standard deviations (RSDs) were in the range of 1-20% for pesticides being tested.

[Structural development of ambulatory surgical care in the United States of America. What can we learn or apply?].

PubMed

Kraus, T; Wolkener, F; Mieth, M; Möller, J; Büchler, M W

2002-10-01

Expansion of ambulatory surgical care is a major focus in United States health politics. In 1996 a total of 31.5 million ambulatory operations were performed, currently accounting for 45% of yearly procedures. Operations in ophthalmology and gastroenterology are predominant. Ambulatory surgery is organized in different forms: "office-based surgery," "hospital outpatient departments," and "ambulatory surgery centers" (ASC). The numbers of ASCs are rapidly increasing. The current proportion of ASCs is 16% of all operations. The type of ambulatory surgery is primarily defined by payors. Medicare standards are the benchmark for private organizations. Recovery care centers now offer postoperative care beyond the former 23-h threshold. This may lead to a further expanded ASC access. Revenues for ambulatory surgery were so far mostly based on fees for service. The implementation of an outpatient prospective payment system ("OPPS") is planned by Medicare, using fixed package prices within a newly defined ambulatory payment classification ("APC"). The dimension of structural changes could be enormous and possibly be compared with the implementation of DRGs in 1983.

MDMA: a social drug in a social context.

PubMed

Kirkpatrick, Matthew G; de Wit, Harriet

2015-03-01

The drug ±3,4-methylenedioxymethamphetamine (MDMA, "ecstasy," "molly") is thought to produce prosocial effects and enhance social interaction. However, in most laboratory studies to date, the participants have been tested under nonsocial conditions, which may not simulate the effects the drug produces in more naturalistic social settings. Healthy experienced MDMA users participated in three laboratory sessions in which they received MDMA (0.5 or 1.0 mg/kg or placebo, double blind). They were randomly assigned to one of three social conditions, in which they were tested alone (solitary (SOL); N = 10), in the presence of a research assistant (research assistant present (RAP); N = 11) or in the presence of another participant who also received the drug (other participant present (OPP); N = 11). As expected, MDMA increased heart rate and blood pressure and produced positive subjective effects in all the three groups. It also increased ratings of attractiveness of another person and increased social interaction in RAP and OPP. The social context affected certain responses to the drug. The effects of MDMA were greater in the OPP condition, compared to the SOL or RAP conditions, on measures of "feel drug," "dizzy," and on cardiovascular. But responses to the drug on other measures, including social behavior, did not differ across the conditions. These findings provide some support for the idea that drugs produce greater effects when they are used in the presence of other drug users. However, the influence of the social context was modest, and it remains to be determined whether other variables related to social context would substantially alter the effects of MDMA or other drugs.

77 FR 38280 - Final Test Guidelines; 810 Series 2000 Product Performance; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... available either electronically through http://www.regulations.gov or in hard copy at the OPP Docket in the...) and revised based on comments received from industry. In addition, formatting changes to incorporate...

48 CFR 302.7100 - HHS standard templates and formats.

Code of Federal Regulations, 2010 CFR

2010-10-01

...). Acquisition Strategy 307.104-70. Annual Acquisition Plan 307.104(a)(5). Competition Advocate Report 306.502(b... Request for Information 315.201(e)(4). FedBizOpps Small Business Sources Sought Notice 319.202-2(a)(3...

75 FR 859 - Exposure Modeling Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0879; FRL-8806-4] Exposure Modeling Public Meeting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Cancellation and Rescheduling of... S. Crystal Drive, Arlington, VA 22202. FOR FURTHER INFORMATION CONTACT: Chuck Peck, Environmental...

4. Historic American Buildings Survey Frank O. Branzetti, Photographer July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey Frank O. Branzetti, Photographer July 23, 1940 (iii) 6- MILE STONE, opp. 1280 BLUE HILL AVE., DORCHESTER - Milestones A, B, E, HHH, III & PPP, Various Dorchester locations, Dorchester, Suffolk County, MA

OPP Guidance for Submission of State and Tribal Water Quality Monitoring Data

EPA Pesticide Factsheets

This guidance describes the process to submit state and tribal surface and groundwater monitoring data for consideration in exposure characterizations for ecological and and human health risk assessments and in risk management decisions for pesticides.

7. Historic American Buildings Survey Frank O. Branzetti, Photographer July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey Frank O. Branzetti, Photographer July 8, 1940 (bb) 6- MILE STONE, CENTRE ST., opp. ALLANDALE ST., ROXBURY - Milestones D, Y, Z, AA, BB, FF & NN, Various Roxbury locations, Roxbury, Suffolk County, MA

5. Historic American Buildings Survey Frank O. Branzetti, Photographer July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey Frank O. Branzetti, Photographer July 8, 1940 (ff) 4- MILE STONE, opp. 862 HUNTINGTON AVE., ROXBURY - Milestones D, Y, Z, AA, BB, FF & NN, Various Roxbury locations, Roxbury, Suffolk County, MA

E-submission chronic toxicology study supplemental files

EPA Pesticide Factsheets

The formats and instructions in these documents are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to OPP for review in support of registration and reevaluation of pesticides.

Guidance on Cumulative Risk Assessment of Pesticide Chemicals that have a Common Mechanism of Toxicity

EPA Pesticide Factsheets

This document provides guidance to OPP scientists for evaluating and estimating the potential human risks associated with such multichemical and multipathway exposures to pesticides. This process is referred to as cumulative risk assessment.

Guidance for Using Non-Definitive Endpoints in Evaluating Risks to Listed and Non-listed Animal Species

EPA Pesticide Factsheets

Ensure consistency among OPP scientists in the use of non-definitive toxicity endpoints for terrestrial and aquatic animals when conducting ecological risk assessments for pesticides and federally listed and non-listed species.

77 FR 72984 - Buprofezin Pesticide Tolerances; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2011-0759; FRL-9371-3] Buprofezin..., 2012, concerning buprofezin pesticide tolerances. This document corrects a typographical error. DATES...: Sec. 180.511 Buprofezin; tolerances for residues. (a) * * * Parts per Commodity million...

Exploring the opportunities and barriers to intermodal rail freight.

DOT National Transportation Integrated Search

2014-04-01

Due to the effects of congestion and rising fuel costs, the need for green transportation and energy : security, and the increasing revenue gaps to finance highway infrastructure construction and renewal, : there is a critical need to explore the opp...

76 FR 16413 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0005; FRL-8865-5] Pesticide Products... announces receipt of applications to register new uses for pesticide products containing currently... number). If you are commenting in a docket that addresses multiple products, please indicate to which...

76 FR 365 - Exposure Modeling Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0879; FRL-8860-5] Exposure Modeling Public Meeting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: An Exposure Modeling... contact the person listed under FOR FURTHER INFORMATION CONTACT, preferably prior to the meeting, to give...

Integration of Biological, Physical/Chemical and Energy Efficient Systems in the CELSS Antarctic Analog: Performance of Prototype Systems and Issues for Life Support

NASA Technical Reports Server (NTRS)

Bubenheim, David L.; Flynn, Michael T.; Lamparter, Richard; Bates, Maynard; Kliss, Mark (Technical Monitor)

1998-01-01

The Controlled Ecological Life Support System (CELSS) Antarctic Analog Project (CAAP) is a joint endeavor between the National Science Foundation, Office of Polar Programs (NSF-OPP), and the National Aeronautics and Space Administration (NASA). The fundamental objective is to develop, deploy, and operate a testbed of advanced life support technologies at the Amundsen-Scott South Pole Station that enable the objectives of both the NSF and NASA. The functions of food production, water purification, and waste treatment, recycle, and reduction provided by CAAP will improve the quality of life for the South Pole inhabitants, reduce logistics dependence, enhance safety, and minimize environmental impacts associated with human presence on the polar plateau. Because of the analogous technical, scientific, and mission features with Planetary missions, such as a mission to Mars, CAAP provides NASA with a method for validating technologies and overall approaches to supporting humans. Prototype systems for waste treatment, water recycle, resource recovery and crop production are being evaluated in a testbed at Ames Research Center. The combined performance of these biological and physical/chemical systems as an integrated function in support of the human habitat will be discussed. Overall system performance will be emphasized. The effectiveness and efficiency of component technologies will be discussed in the context of energy and mass flow within the system and contribution to achieving a mass and energy conservative system. Critical to the discussion are interfaces with habitat functions outside of the closed-loop life support: the ability of the system to satisfy the life support requirements of the habitat and the ability to define input requirements. The significance of analog functions in relation to future Mars habitats will be discussed.

The Antarctic Master Directory -- the Electronic Card Catalog of Antarctic Data

NASA Astrophysics Data System (ADS)

Scharfen, G.; Bauer, R.

2003-12-01

The Antarctic Master Directory (AMD) is a Web-based, searchable record of thousands of Antarctic data descriptions. These data descriptions contain information about what data were collected, where they were collected, when they were collected, who the scientists are, who the point of contact is, how to get the data, and information about the format of the data and what documentation and bibliographic information exists. With this basic descriptive information about content and access for thousands of Antarctic scientific data sets, the AMD is a resource for scientists to advertise the data they have collected and to search for data they need. The AMD has been created by more than twenty nations which conduct research in the Antarctic under the auspices of the Antarctic Treaty. It is a part of the International Directory Network/Global Change Master Directory (IDN/GCMD). Using the AMD is easy. Users can search on subject matter key words, data types, geographic place-names, temporal or spatial ranges, or conduct free-text searches. To search the AMD go to: http://gcmd.nasa.gov/Data/portals/amd/. Contributing your own data descriptions for Antarctic data that you have collected is also easy. Scientists can start by submitting a short data description first (as a placeholder in the AMD, and to satisfy National Science Foundation (NSF) reporting requirements), and then add to, modify or update their record whenever it is appropriate. An easy to use on-line tool and a simple tutorial are available at: http://nsidc.org/usadcc. With NSF Office of Polar Programs (OPP) funding, the National Snow and Ice Data Center (NSIDC) operates the U.S. Antarctic Data Coordination Center (USADCC), partly to assist scientists in using and contributing to the AMD. The USADCC website is at http://nsidc.org/usadcc.

76 FR 52953 - Sheena Shipley; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8885-7] Sheena Shipley; Transfer of Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces that... all other data produced under this contract will be the property of the Environmental Protection...

76 FR 16409 - Summitec Corporation; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8868-3] Summitec Corporation; Transfer of Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This notice announces... their components to human health and the environment. In addition, the contractor shall create Data...

78 FR 14540 - Chlorpyrifos Registration Review; Preliminary Volatilization Assessment; Extension of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0850; FRL-9380-7] Chlorpyrifos Registration... Federal Register issue of February 6, 2013, concerning Chlorpyrifos Registration Review; Preliminary... volatilization assessment for the registration review of chlorpyrifos. EPA received requests from several...

Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism.

PubMed

Told, Reinhard; Palkovits, Stefan; Haslacher, Helmuth; Frantal, Sophie; Schmidl, Doreen; Boltz, Agnes; Lasta, Michael; Kaya, Semira; Werkmeister, René M; Garhöfer, Gerhard; Schmetterer, Leopold

2013-01-01

A common polymorphism in the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration (AMD). In the present study we hypothesized that healthy young subjects homozygous for the high-risk haplotype (CC) show abnormal choroidal blood flow (ChBF) regulation decades before potentially developing the disease. A total of 100 healthy young subjects were included in the present study, of which 4 subjects were excluded due to problems with genotyping or blood flow measurements. ChBF was measured continuously using laser Doppler flowmetry while the subjects performed isometric exercise (squatting) for 6 minutes. The increase in ChBF was less pronounced than the response in ocular perfusion pressure (OPP), indicating for some degree of choroidal blood flow regulation. Eighteen subjects were homozygous for C, 47 subjects were homozygous for T and 31 subjects were heterozygous (CT). The increase in OPP during isometric exercise was not different between groups. By contrast the increase in ChBF was more pronounced in subjects homozygous for the high risk C allele (p = 0.041). This was also evident from the pressure/flow relationship, where the increase in ChBF in homozygous C carriers started at lower OPPs as compared to the other groups. Our data indicate that the regulation of ChBF is abnormal in rs1061170 CC carriers. So far this polymorphism has been linked to age related macular degeneration (AMD) mainly via inflammatory pathways associated with the complement system dysfunction. Our results indicate that it could also be related to vascular factors that have been implicated in AMD pathogenesis.

The influence of cosolvent and heat on the solubility and reactivity of organophosphorous pesticide DNAPL alkaline hydrolysis.

PubMed

Muff, Jens; MacKinnon, Leah; Durant, Neal D; Bennedsen, Lars Frausing; Rügge, Kirsten; Bondgaard, Morten; Pennell, Kurt

2016-11-01

The presented research concerned the compatibility of cosolvents with in situ alkaline hydrolysis (ISAH) for treatment of organophosphorous (OPP) pesticide contaminated sites. In addition, the influence of moderate temperature heat increments was studied as a possible enhancement method. A complex dense non-aqueous phase liquid (DNAPL) of primarily parathion (~50 %) and methyl parathion (~15 %) obtained from the Danish Groyne 42 site was used as a contaminant source, and ethanol and propan-2-ol (0, 25, and 50 v/v%) was used as cosolvents in tap water and 0.34 M NaOH. Both cosolvents showed OPP solubility enhancement at 50 v/v% cosolvent content, with slightly higher OPP concentrations reached with propan-2-ol. Data on hydrolysis products did not show a clear trend with respect to alkaline hydrolysis reactivity in the presence of cosolvents. Results indicated that the hydrolysis rate of methyl-parathion (MP3) decreased with addition of cosolvent, whereas the hydrolysis rate of ethyl-parathion (EP3) remained constant, and overall indications were that the hydrolysis reactions were limited by the rate of hydrolysis rather than NAPL dissolution. In addition to cosolvents, the influence of low-temperature heating on ISAH was studied. Increasing reaction temperature from 10 to 30 °C provided an average rate of hydrolysis enhancement by a factor of 1.4-4.8 dependent on the base of calculation. When combining 50 v/v% cosolvent addition and heating to 30 °C, EP3 solubility was significantly enhanced and results for O,O-diethyl-thiophosphoric acid (EP2 acid) showed a significant enhancement of hydrolysis as well. However, this could not be supported by para-nitrophenol (PNP) data indicating the instability of this product in the presence of cosolvent.

Ecological risk estimation of organophosphorus pesticides in riverine ecosystems.

PubMed

Wee, Sze Yee; Aris, Ahmad Zaharin

2017-12-01

Pesticides are of great concern because of their existence in ecosystems at trace concentrations. Worldwide pesticide use and its ecological impacts (i.e., altered environmental distribution and toxicity of pesticides) have increased over time. Exposure and toxicity studies are vital for reducing the extent of pesticide exposure and risk to the environment and humans. Regional regulatory actions may be less relevant in some regions because the contamination and distribution of pesticides vary across regions and countries. The risk quotient (RQ) method was applied to assess the potential risk of organophosphorus pesticides (OPPs), primarily focusing on riverine ecosystems. Using the available ecotoxicity data, aquatic risks from OPPs (diazinon and chlorpyrifos) in the surface water of the Langat River, Selangor, Malaysia were evaluated based on general (RQ m ) and worst-case (RQ ex ) scenarios. Since the ecotoxicity of quinalphos has not been well established, quinalphos was excluded from the risk assessment. The calculated RQs indicate medium risk (RQ m  = 0.17 and RQ ex  = 0.66; 0.1 ≤ RQ < 1) of overall diazinon. The overall chlorpyrifos exposure was observed at high risk (RQ ≥ 1) based on RQ m and RQ ex at 1.44 and 4.83, respectively. A contradictory trend of RQs > 1 (high risk) was observed for both the general and worst cases of chlorpyrifos, but only for the worst cases of diazinon at all sites from downstream to upstream regions. Thus, chlorpyrifos posed a higher risk than diazinon along the Langat River, suggesting that organisms and humans could be exposed to potentially high levels of OPPs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Hot spring siliceous stromatolites from Yellowstone National Park: assessing growth rate and laminae formation.

PubMed

Berelson, W M; Corsetti, F A; Pepe-Ranney, C; Hammond, D E; Beaumont, W; Spear, J R

2011-09-01

Stromatolites are commonly interpreted as evidence of ancient microbial life, yet stromatolite morphogenesis is poorly understood. We apply radiometric tracer and dating techniques, molecular analyses and growth experiments to investigate siliceous stromatolite morphogenesis in Obsidian Pool Prime (OPP), a hot spring in Yellowstone National Park. We examine rates of stromatolite growth and the environmental and/or biologic conditions that affect lamination formation and preservation, both difficult features to constrain in ancient examples. The "main body" of the stromatolite is composed of finely laminated, porous, light-dark couplets of erect (surface normal) and reclining (surface parallel) silicified filamentous bacteria, interrupted by a less-distinct, well-cemented "drape" lamination. Results from dating studies indicate a growth rate of 1-5 cm year(-1) ; however, growth is punctuated. (14)C as a tracer demonstrates that stromatolite cyanobacterial communities fix CO(2) derived from two sources, vent water (radiocarbon dead) and the atmosphere (modern (14)C). The drape facies contained a greater proportion of atmospheric CO(2) and more robust silica cementation (vs. the main body facies), which we interpret as formation when spring level was lower. Systematic changes in lamination style are likely related to environmental forcing and larger scale features (tectonic, climatic). Although the OPP stromatolites are composed of silica and most ancient forms are carbonate, their fine lamination texture requires early lithification. Without early lithification, whether silica or carbonate, it is unlikely that a finely laminated structure representing an ancient microbial mat would be preserved. In OPP, lithification on the nearly diurnal time scale is likely related to temperature control on silica solubility. © 2011 Blackwell Publishing Ltd.

Dissipation, metabolism and sorption of pesticides used in fruit-packaging plants: Towards an optimized depuration of their pesticide-contaminated agro-industrial effluents.

PubMed

Karas, Panagiotis; Metsoviti, Aria; Zisis, Vasileios; Ehaliotis, Constantinos; Omirou, Michalis; Papadopoulou, Evangelia S; Menkissoglou-Spiroudi, Urania; Manta, Stella; Komiotis, Dimitri; Karpouzas, Dimitrios G

2015-10-15

Wastewaters from the fruit-packaging industry constitute a serious point source contamination with pesticides. In the absence of effective depuration methods, they are discharged in municipal wastewater treatment plants or spread to land. Modified biobeds could be an applicable solution for their treatment. We studied the dissipation of thiabendazole (TBZ), imazalil (IMZ), ortho-phenylphenol (OPP), diphenylamine (DPA) and ethoxyquin (EQ), used by the fruit-packaging industry, in anaerobically digested sewage sludge, liquid aerobic sewage sludge and in various organic substrates (biobeds packing materials) composed of soil, straw and spend mushroom substrate (SMS) in various volumetric ratios. Pesticide sorption was also determined. TBZ and IMZ showed higher persistence especially in the anaerobically digested sewage sludge (DT50=32.3-257.6d), in contrast to OPP and DPA which were rapidly dissipated especially in liquid aerobic sewage sludge (DT50=1.3-9.3d). EQ was rapidly oxidized mainly to quinone imine (QI) which did not persist and dimethyl ethoxyquinoline (EQNL, minor metabolite) which persisted for longer. Sterilization of liquid aerobic sewage sludge inhibited pesticide decay verifying the microbial nature of pesticide dissipation. Organic substrates rich in SMS showed the highest dissipation capacity with TBZ and IMZ DT50s of ca. 28 d compared to DT50s of >50 d in the other substrates. TBZ and IMZ showed the highest sorption affinity, whereas OPP and DPA were weakly sorbed. Our findings suggest that current disposal practices could not guarantee an efficient depuration of effluents from the fruit-packaging industry, whereas SMS-rich biobed organic substrates show efficient depuration of effluents from the fruit-packaging industry via accelerated dissipation even of recalcitrant fungicides. Copyright © 2015 Elsevier B.V. All rights reserved.

The developmental outcomes of P0-mediated ARGONAUTE destabilization in tomato.

PubMed

Hendelman, Anat; Kravchik, Michael; Stav, Ran; Zik, Moriyah; Lugassi, Nitsan; Arazi, Tzahi

2013-01-01

The plant protein ARGONAUTE1 (AGO1) functions in multiple RNA-silencing pathways, including those of microRNAs, key regulators of growth and development. Genetic analysis of ago1 mutants with informative defects has provided valuable insights into AGO1's biological functions. Tomato encodes two AGO1 homologs (SlAGO1s), but mutants have not been described to date. To analyze SlAGO1s' involvement in development, we confirmed that both undergo decay in the presence of the Polerovirus silencing suppressor P0 and produce a transgenic responder line (OP:P0HA) that, upon transactivation, expresses P0 C-terminally fused to a hemagglutinin (HA) tag (P0HA) and destabilizes SlAGO1s at the site of expression. By crossing OP:P0HA with a battery of driver lines, constitutive as well as organ- and stage-specific SlAGO1 downregulation was induced in the F1 progeny. Activated plants exhibited various developmental phenotypes that partially overlapped with those of Arabidopsis ago1 mutants. Plants that constitutively expressed P0HA had reduced SlAGO1 levels and increased accumulation of miRNA targets, indicating compromised SlAGO1-mediated silencing. Consistent with this, they exhibited pleiotropic morphological defects and their growth was arrested post-germination. Transactivation of P0HA in young leaf and floral organ primordia dramatically modified corresponding organ morphology, including the radialization of leaflets, petals and anthers, suggesting that SlAGO1s' activities are required for normal lateral organ development and polarity. Overall, our results suggest that the OP:P0HA responder line can serve as a valuable tool to suppress SlAGO1 silencing pathways in tomato. The suppression of additional SlAGOs by P0HA and its contribution to the observed phenotypes awaits investigation.

Simulation-based ongoing professional practice evaluation in psychiatry: a novel tool for performance assessment.

PubMed

Gorrindo, Tristan; Goldfarb, Elizabeth; Birnbaum, Robert J; Chevalier, Lydia; Meller, Benjamin; Alpert, Jonathan; Herman, John; Weiss, Anthony

2013-07-01

Ongoing professional practice evaluation (OPPE) activities consist of a quantitative, competency-based evaluation of clinical performance. Hospitals must design assessments that measure clinical competencies, are scalable, and minimize impact on the clinician's daily routines. A psychiatry department at a large academic medical center designed and implemented an interactive Web-based psychiatric simulation focusing on violence risk assessment as a tool for a departmentwide OPPE. Of 412 invited clinicians in a large psychiatry department, 410 completed an online simulation in April-May 2012. Participants received scheduled e-mail reminders with instructions describing how to access the simulation. Using the Computer Simulation Assessment Tool, participants viewed an introductory video and were then asked to conduct a risk assessment, acting as a clinician in the encounter by selecting actions from a series of drop-down menus. Each action was paired with a corresponding video segment of a clinical encounter with a standardized patient. Participants were scored on the basis of their actions within the simulation (Measure 1) and by their responses to the open-ended questions in which they were asked to integrate the information from the simulation in a summative manner (Measure 2). Of the 410 clinicians, 381 (92.9%) passed Measure 1,359 (87.6%) passed Measure 2, and 5 (1.2%) failed both measures. Seventy-five (18.3%) participants were referred for focused professional practice evaluation (FPPE) after failing either Measure 1, Measure 2, or both. Overall, Web-based simulation and e-mail engagement tools were a scalable and efficient way to assess a large number of clinicians in OPPE and to identify those who required FPPE.

Land Spreading of Wastewaters from the Fruit-Packaging Industry and Potential Effects on Soil Microbes: Effects of the Antioxidant Ethoxyquin and Its Metabolites on Ammonia Oxidizers.

PubMed

Papadopoulou, Evangelia S; Tsachidou, Bella; Sułowicz, Sławomir; Menkissoglu-Spiroudi, Urania; Karpouzas, Dimitrios G

2016-01-15

Thiabendazole (TBZ), imazalil (IMZ), ortho-phenylphenol (OPP), diphenylamine (DPA), and ethoxyquin (EQ) are used in fruit-packaging plants (FPP) with the stipulation that wastewaters produced by their application would be depurated on site. However, no such treatment systems are currently in place, leading FPP to dispose of their effluents in agricultural land. We investigated the dissipation of those pesticides and their impact on soil microbes known to have a key role on ecosystem functioning. OPP and DPA showed limited persistence (50% dissipation time [DT50], 0.6 and 1.3 days) compared to TBZ and IMZ (DT50, 47.0 and 150.8 days). EQ was rapidly transformed to the short-lived quinone imine (QI) (major metabolite) and the more persistent 2,4-dimethyl-6-ethoxyquinoline (EQNL) (minor metabolite). EQ and OPP exerted significant inhibition of potential nitrification, with the effect of the former being more persistent. This was not reflected in the abundance (determined by quantitative PCR [qPCR]) of the amoA gene of ammonia-oxidizing bacteria (AOB) and archaea (AOA). Considering the above discrepancy and the metabolic pattern of EQ, we further investigated the hypothesis that its metabolites and not only EQ were toxic to ammonia oxidizers. Potential nitrification, amoA gene abundance, and amoA gene transcripts of AOB and AOA showed that QI was probably responsible for the inhibition of nitrification. Our findings have serious ecological and practical implications for soil productivity and N conservation in agriculturally impacted ecosystems and stress the need to include metabolites and RNA-based methods when the soil microbial toxicity of pesticides is assessed. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Land Spreading of Wastewaters from the Fruit-Packaging Industry and Potential Effects on Soil Microbes: Effects of the Antioxidant Ethoxyquin and Its Metabolites on Ammonia Oxidizers

PubMed Central

Papadopoulou, Evangelia S.; Tsachidou, Bella; Sułowicz, Sławomir; Menkissoglu-Spiroudi, Urania

2015-01-01

Thiabendazole (TBZ), imazalil (IMZ), ortho-phenylphenol (OPP), diphenylamine (DPA), and ethoxyquin (EQ) are used in fruit-packaging plants (FPP) with the stipulation that wastewaters produced by their application would be depurated on site. However, no such treatment systems are currently in place, leading FPP to dispose of their effluents in agricultural land. We investigated the dissipation of those pesticides and their impact on soil microbes known to have a key role on ecosystem functioning. OPP and DPA showed limited persistence (50% dissipation time [DT50], 0.6 and 1.3 days) compared to TBZ and IMZ (DT50, 47.0 and 150.8 days). EQ was rapidly transformed to the short-lived quinone imine (QI) (major metabolite) and the more persistent 2,4-dimethyl-6-ethoxyquinoline (EQNL) (minor metabolite). EQ and OPP exerted significant inhibition of potential nitrification, with the effect of the former being more persistent. This was not reflected in the abundance (determined by quantitative PCR [qPCR]) of the amoA gene of ammonia-oxidizing bacteria (AOB) and archaea (AOA). Considering the above discrepancy and the metabolic pattern of EQ, we further investigated the hypothesis that its metabolites and not only EQ were toxic to ammonia oxidizers. Potential nitrification, amoA gene abundance, and amoA gene transcripts of AOB and AOA showed that QI was probably responsible for the inhibition of nitrification. Our findings have serious ecological and practical implications for soil productivity and N conservation in agriculturally impacted ecosystems and stress the need to include metabolites and RNA-based methods when the soil microbial toxicity of pesticides is assessed. PMID:26590271

Report: Measuring the Impact of the Food Quality Protection Act: Challenges and Opportunities

EPA Pesticide Factsheets

Report #2006-P-00028, August 1, 2006. The EPA OIG found that OPP has primarily measured its success and the impact of FQPA by adherence to its reregistration schedule rather than by reductions in risk to children’s health.

75 FR 6656 - SFIREG Pesticide Operations and Management Working Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... regarding important issues related to human health, environmental exposure to pesticides, and insight into... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0001; FRL-8811-3] SFIREG Pesticide Operations and...: The Association of American Pesticide Control Officials (AAPCO)/State FIFRA Issues Research and...

77 FR 16544 - Pesticide Product Registration Approvals

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

...? You may be potentially affected by this action if you are an agricultural producer, food manufacturer.... No. 84059-10) for use on agricultural and greenhouse crops, including vegetables, fruit, flowers... Number: EPA-HQ-OPP- 2010-0081. a. Description of New Use: Novozymes Biologicals, Inc. submitted...

78 FR 7778 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0793; FRL-9527-3] Information Collection Request... Annual Measures Reporting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency has submitted an information collection request (ICR), ``Pesticide Environmental...

76 FR 10026 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

... popcorn. Contact: Autumn Metzger, Registration Division, (703) 305-5314, [email protected] . 10[email protected] . 11. Registration Number/File Symbol: 87358-R. Docket Number: EPA- HQ-OPP-2010-1038. Company... . List of Subjects Environmental protection, Pesticides and pest. Dated: February 10, 2011. G. Jeffrey...

78 FR 32574 - Azoxystrobin; Pesticide Tolerance; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-31

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2012-0283; FRL-9387-4] Azoxystrobin..., establishing new and modifying existing tolerances for residues of azoxystrobin. EPA inadvertently omitted the... for residues of the fungicide azoxystrobin in or on various commodities. EPA inadvertently omitted the...

76 FR 69736 - Primus Solutions, Inc., and Arctic Slope Regional Corp.; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8891-5] Primus Solutions, Inc., and Arctic Slope Regional Corp.; Transfer of Data AGENCY: Environmental Protection Agency (EPA). ACTION... its subcontractor, Arctic Slope Regional Corporation (ASRC) in [[Page 69737

76 FR 40811 - Maneb; Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

...; Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is... established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0327. All... . SUPPLEMENTARY INFORMATION: I. General Information A. Does this action apply to me? You may be potentially...

78 FR 17204 - Pesticide Reregistration Performance Measures and Goals; Annual Progress Report; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0938; FRL-9374-7] Pesticide Reregistration Performance Measures and Goals; Annual Progress Report; Notice of Availability AGENCY: Environmental... EPA's progress report in meeting its performance measures and goals for pesticide reregistration...

77 FR 19662 - Pesticide Reregistration Performance Measures and Goals; Annual Progress Report; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0959; FRL-9343-5] Pesticide Reregistration Performance Measures and Goals; Annual Progress Report; Notice of Availability AGENCY: Environmental... EPA's progress report in meeting its performance measures and goals for pesticide reregistration...

78 FR 71609 - Methiocarb, Lambda-Cyhalothrin, Permethrin and Prodiamine; Notice of Receipt of Requests To...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-1017; FRL-9902-77] Methiocarb, Lambda-Cyhalothrin... receipt of requests by the registrants to voluntarily amend their Methiocarb, Lambda- Cyhalothrin... Willowood Lambda Cyhalothrin LLC, Gowan Company, Farnam Companies, Inc., Pyxis Regulatory Consulting, Inc...

75 FR 11175 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to... the document by docket ID number and other identifying information (subject heading, Federal Register...). 4. File Symbol: 5481-LAI. Docket Number: EPA-HQ-OPP-2010-0064. Applicant: Technology Sciences Group...

77 FR 75039 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

...- 671A) is available to enforce the tolerance expression. The method may be requested from: Chief... action, identified by docket identification (ID) number EPA-HQ-OPP-2011-0772, is available at http://www... additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER INFORMATION...

75 FR 22400 - Draft Test Guidelines; Reopening of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0681; FRL-8822-3] Draft Test Guidelines... draft test guidelines for product performance of public health uses of antimicrobial agents. EPA...-8437-2). In that document, EPA announced the availability of four draft test guidelines for product...

77 FR 15750 - Final Test Guidelines; OCSPP 810 Series; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0681; FRL-9332-4] Final Test Guidelines; OCSPP.... SUMMARY: EPA is announcing the availability of the final test guidelines for Series 810--Product Performance Test Guidelines, specifically public health uses of antimicrobial agents (OCSPP 810.2000...

78 FR 3418 - Pesticides; Draft Guidance for Pesticide Registrants on Web-Distributed Labeling for Pesticide...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... with pesticide labeling requirements and thereby protecting human health and the environment from... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0906; FRL-9374-4] Pesticides; Draft Guidance for Pesticide Registrants on Web- Distributed Labeling for Pesticide Products AGENCY: Environmental Protection...

76 FR 71562 - Emergint Technologies, Inc.; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038: FRL-9326-9] Emergint Technologies, Inc... Cosmetic Act (FFDCA), including information that may have been claimed as Confidential Business Information (CBI) by the submitter, will be transferred to Emergint Technologies, Inc. in accordance with 40 CFR 2...

78 FR 43880 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... personal information provided, unless the comment includes profanity, threats, information claimed to be... ENVIRONMENTAL PROTECTION AGENCY [EPA-OPP-2012-0544; FRL-9534-8] Information Collection Request... Environmental Protection Agency has submitted an information collection request (ICR), ``Notice of Supplemental...

77 FR 12295 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... (703)308-8715 Do 29964-RT [email protected] Thomas Harris (703)308-9423 Registration Division... LLC, P.O. Box 18300, Greensboro, NC 27419. Product names: DuPont--Cyazypyr Technical, Benevia Insect..., industrial, and agricultural structures. (T. Harris). 2. File symbol: 29964-RT. Docket number: EPA-HQ-OPP...

77 FR 44233 - Clothianidin; Emergency Petition To Suspend; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0344; FRL-9355-1] Clothianidin; Emergency.... SUMMARY: PANNA and others submitted a request for the EPA to immediately suspend Clothianidin and take... the EPA suspend registrations for the insecticide clothianidin for the four following reasons: (1) To...

78 FR 13295 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

...: [email protected] . 5. PP 2F8130. (EPA-HQ-OPP-2012-0576). Arysta LifeScience North America, LLC...-2012-0576). Arysta LifeScience North America, LLC, requests to revise the tolerances in 40 CFR 180.609...

78 FR 25436 - Pesticide Experimental Use Permits; Receipt of Applications; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0106; FRL-9385-4] Pesticide Experimental Use...: Notice. SUMMARY: This notice announces EPA's receipt of applications requesting experimental use permits... treatment and meaningful involvement of any group, including minority and/or low income populations, in the...

Consideration of the FQPA Safety Factor and Other Uncertainty Factors in Cumulative Risk Assessment of Chemicals Sharing a Common Mechanism of Toxicity

EPA Pesticide Factsheets

This guidance document provides OPP's current thinking on application of the provision in FFDCA about an additional safety factor for the protection of infants and children in the context of cumulative risk assessments.

75 FR 17737 - Industrial Economics, Incorporated; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0194; FRL-8820-2] Industrial Economics... (CBI) by the submitter, will be transferred to Industrial Economics, Incorporated in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). Industrial Economics, Incorporated has been awarded multiple...

76 FR 22045 - Fluopicolide; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... increased quantitative susceptibility of rat or rabbit fetuses to in utero or postnatal exposure to... is identified as docket ID number EPA-HQ-OPP-2006-0481. A quantitative reassessment of the BAM risk... fluopicolide and separately, its metabolite, BAM in food as follows: i. Acute exposure. Quantitative acute...

75 FR 22407 - Versar, Inc. and Syracuse Research Corporation; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... subcontractor, Syracuse Research Corporation, have been awarded a contract to perform work for OPP, and access... Versar, Inc. and its subcontractor, Syracuse Research Corporation, have completed their work. List of... Research Corporation; Transfer of Data AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...

76 FR 56751 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... Chemical Co., (464-EUP-RNA). Pesticide Chemical: Dibromomalonamide. Summary of Request: Evaluation for use... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0670; FRL-8886-4] Pesticide Experimental Use...: Notice. SUMMARY: This notice announces EPA's receipt of an application 464-EUP- RNA from Dow Chemical Co...

EPA Announces FIFRA Science Advisory Panel Meeting on PBPK and Asks for Nominations for Panel Members

EPA Pesticide Factsheets

On June 6, 2017, the EPA published a Federal Register Notice (EPA-HQ-OPP-2017-0180) for both the meeting and seeking nominees to serve as ad hoc expert members of the FIFRA SAP on physiologically based pharmacokinetic (PBPK) modeling.

77 FR 70998 - Azinphos-Methyl; Product Cancellation Order and Amendments To Terminate Uses; Amendment to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-28

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2005-0061; FRL-9363-9] Azinphos-Methyl; Product... February 20, 2008 concerning the cancellation of products containing azinphos-methyl (AZM). EPA corrected... cancellation order, all sale, distribution, and use of products containing AZM was prohibited after September...

75 FR 22406 - Avaya Government Solutions; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0194; FRL-8821-2] Avaya Government Solutions... (CBI) by the submitter, will be transferred to Avaya Government Solutions in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). Avaya Government Solutions has been awarded multiple contracts to perform...

76 FR 59395 - Primus Solutions, Inc.; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8889-5] Primus Solutions, Inc... (CBI) by the submitter, will be transferred to Primus Solutions, Inc., in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). Primus Solutions, Inc., has been awarded multiple contracts to perform work...

77 FR 47296 - Flutriafol; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

... objections and hearing requests are provided in 40 CFR 178.25(b). In addition to filing an objection or.... Tolerances were previously established on November 9, 2011 for banana, grape, raisin; pome and stone fruit... Imported Bananas,'' at p. 40 in docket ID number EPA-HQ-OPP-2010-0875. [[Page 47298

75 FR 35653 - Thiamethoxam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2009-0737; FRL-8830-4] Thiamethoxam... regulation establishes tolerances for residues of thiamethoxam in or on onion, dry bulb. Syngenta Crop... thiamethoxam (3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl-N-nitro-4H-1,3,5- oxadiazin-4-imine) and its...

48 CFR 305.205 - Special situations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... situations. (a) An OPDIV may issue an advance notice, entitled “Research and Development Sources Sought,” in Federal Business Opportunities (FedBizOpps), in accordance with the requirements of FAR 5.205(a). The... requirement. The notice is not intended to solicit technical, scientific, or business information for project...

76 FR 69653 - Abamectin (avermectin); Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... are available in Pesticide Analytical Manual II (PAM II) for citrus and processed fractions (Method I... (ID) number EPA-HQ-OPP-2010-0619. All documents in the docket are listed in the docket index available... available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted...

DESIGNING PESTICIDE METABOLIC PATHWAY/DEGRADATE DATABASES FOR REGISTRANT SUBMITTED HEALTH EFFECTS/ECOLOGICAL EFFECTS DATA

EPA Science Inventory

OPPTS requires information on the toxic effects of pesticide metabolites as well as the parent chemical. Currently, OPP receives metabolic maps with registrant study data submissions, but there is no efficient way to access previously submitted maps on similar chemicals to help w...

75 FR 60112 - SFIREG Full Committee; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... to pesticides, and insight into EPA's decision-making process. You are invited and encouraged to... benchmarks. 2. EPA use of monitoring data vs. use of modeling outputs in registration review process. 3... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0001; FRL-8847-2] SFIREG Full Committee; Notice...

Reduced lentivirus susceptibility in sheep with TMEM154 mutations

USDA-ARS?s Scientific Manuscript database

Visna/Maedi, or ovine progressive pneumonia (OPP) as it is known in the U.S., is an incurable slow-acting disease of sheep caused by persistent lentivirus infection. This disease affects multiple tissues, including those of the respiratory and central nervous systems. Our aim was to identify ovine g...

78 FR 76612 - Notice of Receipt of Pesticide Products; Registration Applications To Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

... Herbicide). Docket ID number: EPA-HQ-OPP-2013-0768. Applicant: BASF Corporation, 26 Davis Dr., P.O. Box 13528, Research Triangle Park, NC 27709. Active ingredient: Pendimethalin. Product type: Herbicide... ingredient: Sulfentrazone. Product type: Herbicide. Proposed use: Formulation into end-use sulfentrazone...

75 FR 4380 - Draft Test Guidelines; Notice of Availability and Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0681; FRL-8437-2] Draft Test Guidelines; Notice...: Notice. SUMMARY: EPA is announcing the availability of four draft test guidelines for Product Performance... holidays. The Docket Facility telephone number is (703) 305-5805. Electronic access to the OPPTS Test...

77 FR 74003 - Pesticides; Draft Guidance for Pesticide Registrants on Antimicrobial Pesticide Products With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... humans. ``Fungistats'' are antimicrobial pesticides intended for aesthetic or cosmetic purposes and only... to improve protection of public health through proper use of mold-related pesticides. III. Do PR... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0539; FRL-9362-3] Pesticides; Draft Guidance for...

77 FR 8861 - Pesticide Products; Receipt of Applications To Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Protection, LLC, P.O. Box 18300, Greensboro, NC 27419. Active ingredient: Difenoconazole. Proposed Uses...: EPA- HQ-OPP-2011-0086. Company name and address: Syngenta Crop Protection, LLC, P.O. Box 18300... Protection, LLC, P.O. Box 18300, Greensboro, NC 27419. Active ingredient: Difenoconazole and Propiconazole...

75 FR 29534 - Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0434; FRL-8826-6] Inorganic Nitrates-Nitrite... for the registration review of inorganic nitrates - nitrites, carbon and carbon dioxide, and gas... identifies those species for which exposure and effects may occur for all inorganic nitrates- nitrites...

76 FR 22067 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

...., Princeton, NJ 08540 on behalf of Arkion Life Sciences, 551 Mews Drive, Suite J, New Castle, DE 19720...) 3055407, e-mail address: [email protected] . 3. PP 1F7836. (EPA-HQ-OPP-2011-0283). Dow AgroSciences, LLC...

77 FR 2539 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0689; FRL-9332-6] Pesticide Experimental Use... treatment and meaningful involvement of any group, including minority and/or low income populations, in the... potential environmental justice issues, the Agency seeks information on any groups or segments of the...

75 FR 1772 - Pesticide Experimental Use Permits; Receipt of Applications; Comment Requests

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0615; FRL-8433-2] Pesticide Experimental Use... Pioneer Hi-Bred International, Inc. requesting experimental use permits (EUPs) for seed blends of the... meaningful involvement of any group, including minority and/or low income populations, in the development...

Soil drying effects on the carbon isotope composition of soil respiration

EPA Science Inventory

Stable isotopes are used widely as a tool for determining sources of carbon (C) fluxes in ecosystem C studies. Environmental factors that change over time, such as moisture, can create dynamic changes in the isotopic composition of C assimilated by plants, and offers a unique opp...

77 FR 52240 - Pendimethalin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

..., identified by docket ID number EPA-HQ-OPP-2011-0521, by one of the following methods: Federal eRulemaking... relationship of the results of the studies to human risk. EPA has also considered available information... subchronic rat and mouse studies was manifested as alterations in thyroid hormones, increased thyroid weight...

77 FR 48902 - S-Metolachlor; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... or hearing request, identified by docket ID number EPA-HQ-OPP-2011-0657, by one of the following... registrant, which is available in the docket, http://www.regulations.gov . EPA received one comment to the... relationship of the results of the studies to human risk. EPA has also considered available information...

78 FR 13264 - Acetochlor; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... one study. In three reproduction toxicity studies in rats, offspring effects (decreased pup weights in... or hearing request, identified by docket ID number EPA-HQ-OPP-2012-0302, by one of the following... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

78 FR 54248 - SFIREG Full Committee; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-03

.... SUMMARY: The Association of American Pesticide Control Officials (AAPCO)/State FIFRA Issues Research and... for the meeting and sets forth the tentative agenda topics. DATES: The meeting will be held on Monday...://www.epa.gov/dockets . II. Tentative Agenda Topics 1. OPP update on methomyl. 2. OECA update on...

76 FR 4684 - Pesticides; Science Policies; Notice of Withdrawal and Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0830; FRL-8854-2] Pesticides; Science Policies...: Notice. SUMMARY: EPA announces the withdrawal of two pesticide science policy documents that are no... of two updated pesticide science policy documents, entitled: ``The Development and Use of the Index...

76 FR 31606 - Cryolite Registration Review Docket; Extension of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... identification (ID) number EPA- HQ-OPP-2011-0173, must be received on or before July 5, 2011. ADDRESSES: Follow..., 2011. FOR FURTHER INFORMATION CONTACT: Eric Miederhoff, Pesticide Re- evaluation Division (7508P... March 30, 2011 Federal Register document. If you have questions, consult the person listed under FOR...

75 FR 77635 - Cancellation Orders for Certain Pesticide Registrations: Ethofumesate and Monosodium...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

..., 2010. FOR FURTHER INFORMATION CONTACT: Maia Tatinclaux, Pesticide Re- evaluation Division (7508P... the applicability of this action to a particular entity, consult the person listed under FOR FURTHER... established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2009-1017. Publicly...

77 FR 21767 - Imidacloprid, Methomyl, and Oxamyl; Cancellation Order for Amendments To Terminate Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0933; FRL-9342-2] Imidacloprid, Methomyl, and... requested by registrants and accepted by the Agency, of products containing imidacloprid, methomyl, and... Requests from the registrants listed in Table 2 of Unit II to voluntarily amend certain imidacloprid...

76 FR 53454 - Exposure Modeling Public Meeting; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0879; FRL-8885-9] Exposure Modeling Public...: An Exposure Modeling Public Meeting (EMPM) will be held for one day on September 20, 2011. This... Building), Fourth Floor Conference Center (S-4370-80), 2777 S. Crystal Drive, Arlington, VA 22202. FOR...

75 FR 39014 - Exposure Modeling Public Meeting; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0879; FRL-8834-3] Exposure Modeling Public...: An Exposure Modeling Public Meeting (EMPM) will be held for 1 day on July 27, 2010. This notice... Yard (South Building), Fourth Floor, South Conference Room (S-4370/80), 2777 S. Crystal Drive...

New Results from the Flare Genesis Experiment

NASA Astrophysics Data System (ADS)

Rust, D. M.; Bernasconi, P. N.; Eaton, H. A.; Keller, C.; Murphy, G. A.; Schmieder, B.

2000-05-01

From January 10 to 27, 2000, the Flare Genesis solar telescope observed the Sun while suspended from a balloon in the stratosphere above Antarctica. The goal of the mission was to acquire long time series of high-resolution images and vector magnetograms of the solar photosphere and chromosphere. Images were obtained in the magnetically sensitive Ca I line at 6122 Angstroms and at H-alpha (6563 Angstroms). The FGE data were obtained in the context of Max Millennium Observing Campaign #004, the objective of which was to study the ``Genesis of Solar Flares and Active Filaments/Sigmoids." Flare Genesis obtained about 26,000 usable images on the 8 targeted active regions. A preliminary examination reveals a good sequence on an emerging flux region and data on the M1 flare on January 22, as well as a number of sequences on active filaments. We will present the results of our first analysis efforts. Flare Genesis was supported by NASA grants NAG5-4955, NAG5-5139, and NAG5-8331 and by NSF grant OPP-9615073. The Air Force Office of Scientific Research and the Ballistic Missile Defense Organization supported early development of the Flare Genesis Experiment.

Managing simulation-based training: A framework for optimizing learning, cost, and time

NASA Astrophysics Data System (ADS)

Richmond, Noah Joseph

This study provides a management framework for optimizing training programs for learning, cost, and time when using simulation based training (SBT) and reality based training (RBT) as resources. Simulation is shown to be an effective means for implementing activity substitution as a way to reduce risk. The risk profile of 22 US Air Force vehicles are calculated, and the potential risk reduction is calculated under the assumption of perfect substitutability of RBT and SBT. Methods are subsequently developed to relax the assumption of perfect substitutability. The transfer effectiveness ratio (TER) concept is defined and modeled as a function of the quality of the simulator used, and the requirements of the activity trained. The Navy F/A-18 is then analyzed in a case study illustrating how learning can be maximized subject to constraints in cost and time, and also subject to the decision maker's preferences for the proportional and absolute use of simulation. Solution methods for optimizing multiple activities across shared resources are next provided. Finally, a simulation strategy including an operations planning program (OPP), an implementation program (IP), an acquisition program (AP), and a pedagogical research program (PRP) is detailed. The study provides the theoretical tools to understand how to leverage SBT, a case study demonstrating these tools' efficacy, and a set of policy recommendations to enable the US military to better utilize SBT in the future.

32 CFR 728.24 - Navy and Marine Corps Officer Candidate Programs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Navy and Marine Corps Officer Candidate Programs... Reserve Components, Reserve Officers' Training Corps, Navy and Marine Corps Officer Candidate Programs, and National Guard Personnel § 728.24 Navy and Marine Corps Officer Candidate Programs. Members of the...

32 CFR 728.24 - Navy and Marine Corps Officer Candidate Programs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Navy and Marine Corps Officer Candidate Programs... Reserve Components, Reserve Officers' Training Corps, Navy and Marine Corps Officer Candidate Programs, and National Guard Personnel § 728.24 Navy and Marine Corps Officer Candidate Programs. Members of the...

76 FR 16770 - Petition To Suspend and Cancel All Registrations for the Soil Fumigant Iodomethane (Methyl Iodide...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0541; FRL-8841-7] Petition To Suspend and Cancel All Registrations for the Soil Fumigant Iodomethane (Methyl Iodide); Notice of Availability AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: On March 31, 2010, EPA received a petition from...

78 FR 13337 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... conduct experimental field tests on 10 acres or more of land or one acre or more of water. Pursuant to 40... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0010; FRL-9377-5] Pesticide Experimental Use..., requesting an experimental use permit (EUP) for the plant growth regulator, forchlorfenuron. The Agency has...

A SURVEY OF EPA/OPP AND OPEN LITERATURE ON SELECTED PESTICIDE CHEMICALS III. MUTAGENICITY AND CARCINOGENICITY OF BENOMYL AND CARBENDAZIM

EPA Science Inventory

Abstract
The known aneuploidogens, benomyl and its metabolite, carbendazim (methyl 2- benzimidazole carbamate or MBC), were selected for the third in a series of ongoing projects with selected pesticides. Mutagenicity and carcinogenicity data submitted to the U.S. Environmen...

77 FR 5012 - Environmental Protection Agency, Department of Health and Human Services and Department of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-9328-7] Environmental Protection Agency, Department of Health and Human Services and Department of Agriculture; Memorandum of Understanding Regarding... Department of Human Services (HHS) and the U.S. Department of Agriculture (USDA). HHS's Centers for Disease...

76 FR 44906 - Foremost 4809-ES Insect-O-Fog; Amended Cancellation Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-1017; FRL-8880-8] Foremost 4809-ES Insect-O-Fog... cancellation order for the pesticide product Foremost 4809-ES Insect-O-Fog, a pesticide product containing Piperonyl Butoxide and Pyrethrins. The registrant of Foremost 4809-ES Insect-O-Fog--Delta Foremost Chemical...

The Repeated Name Penalty, the Overt Pronoun Penalty, and Topic in Japanese

ERIC Educational Resources Information Center

Shoji, Shinichi; Dubinsky, Stanley; Almor, Amit

2017-01-01

When reading sentences with an anaphoric reference to a subject antecedent, repeated-name anaphors result in slower reading times relative to pronouns (the Repeated Name Penalty: RNP), and overt pronouns are read slower than null pronouns (the Overt Pronoun Penalty: OPP). Because in most languages previously tested, the grammatical subject is…

77 FR 52331 - Notice of Receipt of Requests for Amendments To Delete Uses in Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... on or before September 28, 2012. ADDRESSES: Submit your comments, identified by docket identification... action, identified by docket identification (ID) number EPA-HQ-OPP-2012-0548, is available either... Pyrethrins and Piperonyl Use on Pre-Harvest Tree Butoxide. Nuts, Cereal Grains and Pasture Grasses. 2724-761...

77 FR 2910 - Bacillus Amyloliquefaciens Strain D747; Exemption From the Requirement of a Tolerance; Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2010-0944; FRL-9334-3] Bacillus... requirement of a tolerance for residues of Bacillus amyloliquefaciens strain D747 (formerly known as Bacillus subtilis variant amyloliquefaciens strain D747). This document is being issued to correct the typographical...

76 FR 25281 - Atrazine, Chloroneb, Chlorpyrifos, Clofencet, Endosulfan, et al.; Proposed Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-04

... use of profanity or personal threats. viii. Make sure to submit your comments by the comment period... atrazine, establish tolerances for endosulfan, and make minor revisions to tolerance expressions for a few..., 2011. ADDRESSES: Submit your comments, identified by docket identification (ID) number EPA-HQ-OPP-2011...

78 FR 18511 - Thiamethoxam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... Revised PHI and Tolerance for Pepper and Eggplant (Crop Subgroup 8-10B).'' B. Toxicological Points of... Pepper and Eggplant (Crop Subgroup 8-10B),'' available in the docket EPA-HQ-OPP-2011-0860, at http://www... Tolerance for Tea; and Revised PHI and Tolerance for Pepper and Eggplant (Crop Subgroup 8-10B),'' available...

78 FR 3420 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... human health, including exposure of residues of the pesticide to infants and children. If the emergency... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0019; FRL-9375-2] Pesticide Emergency Exemptions..., Fungicide, and Rodenticide Act (FIFRA) for use of pesticides as listed in this notice. The exemptions were...

77 FR 8860 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... harm'' to human health, including exposure of residues of the pesticide to infants and children. If the... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0019; FRL-9337-4] Pesticide Emergency Exemptions..., Fungicide, and Rodenticide Act (FIFRA) for use of pesticides as listed in this notice. The exemptions were...

Impact of cooking formulation on descriptive flavor and ORAC values of whole grain colored rice.

USDA-ARS?s Scientific Manuscript database

Whole grain rice is high in healthful polyphenols, which can impart less desirable flavors, such as, bitterness and astringency. Other flavors may be associated with polyphenols. Rice is prepared with water and sometimes salt and/or oil are added to the cooking water; otherwise, there is little opp...

75 FR 13282 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

.... Company name and address: Arysta LifeScience, North Americal LLC, 15401 Weston Parkway, Suite 150, Cary... CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709. Active...: EPA-HQ-OPP-2008-0262. Company name and address: Bayer CropScience, P.O. Box 12014, 2T.W. Alexander...

75 FR 11884 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

.... Company Name and Address: Arysta LifeScience North America, 15401 Weston Parkway, Suite 150, Cary, NC... Number: EPA-HQ-OPP-2009-0279. Company Name and Address: Bayer CropScience, P.O. Box 12014, 2 T.W...: Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709. Active...

75 FR 71699 - Pesticide Experimental Use Permits; Receipt of Amendment and Extension Applications; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0926; FRL-8853-7] Pesticide Experimental Use... and 264-EUP-143 from Bayer CropScience LP requesting to amend and extend the existing experimental use... fair treatment and meaningful involvement of any group, including minority and/or low income...

76 FR 5808 - Petition for a Ban on Triclosan; Notice of Availability; Extension of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... and widespread use'' of triclosan poses significant risks to human health and the environment. In... degradation products on human health and the environment, failed to conduct separate assessments for triclosan... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0548; FRL-8863-6] Petition for a Ban on Triclosan...

76 FR 20537 - Etoxazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA..., identified by docket ID number EPA-HQ-OPP-2010-0063, by one of the following methods: Federal eRulemaking...), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA...

77 FR 43524 - Acetamiprid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

...-CBI objection or hearing request, identified by docket ID number EPA-HQ-OPP-2011-0792, by one of the... available in the docket, http://www.regulations.gov . One comment was received on the notice of filing. EPA... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

78 FR 32250 - CDM Smith and Dynamac Corp; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0036; FRL-9387-5] CDM Smith and Dynamac Corp... the submitter, will be transferred to CDM Smith and its subcontractor, Dynamac Corp, in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). CDM Smith and its subcontractor, Dynamac Corp, have been...

76 FR 40727 - Methyl Parathion; Rescission of Previously Issued Cancellation Orders and Issuance of Revised...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0332; FRL-8879-6] Methyl Parathion; Rescission of... containing methyl parathion, pursuant to section 6(f)(1) of the Federal Insecticide, Fungicide, and... extent they are applicable to methyl parathion products because the orders did not correctly reflect the...

Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis

USDA-ARS?s Scientific Manuscript database

The isoflavone phytoestrogens found in the soy protein isolate used in soy infant formulas have been shown to have estrogenic actions in the developing male reproductive tract resulting in reproductive toxicity. However, few studies have examined potential estrogenicity of soy protein isolate as opp...

76 FR 23588 - Notice of Receipt of Requests To Voluntarily Cancel Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

...-00123 Misty Flea Killer Phenothrin. 010807-00151 One Shot ``foamy'' Alkyl*dimethylbenzylammoniumchloride... EPA-HQ-OPP-2010-0014, by one of the following methods: Federal eRulemaking Portal: http://www... (7502P), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr...

77 FR 77077 - Pesticide Product Registration; Receipt of Applications for New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... affected entities may include: Crop production (NAICS code 111). Animal production (NAICS code 112). Food... File Symbol: 264-1049 and 72155- RNO. Docket ID Number: EPA-HQ-OPP-2012-0946. Applicant: Bayer CropScience, 2 T. W. Alexander Drive, P. O. Box 12014, Research Triangle Park, NC 27709. Active Ingredient...

78 FR 59019 - Product Cancellation Order for Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... requested cancellations. Any distribution, sale, or use of the products subject to this cancellation order... distribution, sale, or use of existing stocks of the products identified in Table 1 of Unit II. in a manner... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0014; FRL-9400-7] Product Cancellation Order for...

76 FR 3135 - Pesticide Experimental Use Permit; Receipt of Extension Application;

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0608; FRL-8855-3] Pesticide Experimental Use... (PIP) [Event 5307] Bacillus thuringiensis eCry3.1Ab protein and the genetic material necessary for its production (vector pSYN12274) in Event 5307 corn (SYN-[Oslash]53[Oslash]7-1) and combined and single trait...

75 FR 82010 - AceInfo Solutions and Avaya Government Solutions, Koansys LLC, and Quality Associates Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... Government Solutions, Koansys LLC, and Quality Associates Inc.; Transfer of Data AGENCY: Environmental...Info Solutions and its subcontractors, Avaya Government Solutions, Koansys LLC, and Quality Associates Inc. have been awarded a contract to perform work for OPP, and access to this information will enable...

Do Changes in Hospital Outpatient Payments Affect the Setting of Care?

PubMed Central

He, Daifeng; Mellor, Jennifer M

2013-01-01

Objective To examine whether decreases in Medicare outpatient payment rates under the Outpatient Prospective Payment System (OPPS) caused outpatient care to shift toward the inpatient setting. Data Sources/Study Setting Hospital inpatient and outpatient discharge files from the Florida Agency for Health Care Administration from 1997 through 2008. Study Design This study focuses on inguinal hernia repair surgery, one of the most commonly performed surgical procedures in the United States. We estimate multivariate regressions of inguinal hernia surgery counts in the outpatient setting and in the inpatient setting. The key explanatory variable is the time-varying Medicare payment rate specific to the procedure and hospital. Control variables include time-varying hospital and county characteristics and hospital and year-fixed effects. Principal Findings Outpatient hernia surgeries fell in response to OPPS-induced rate cuts. The volume of inpatient hernia repair surgeries did not increase in response to reductions in the outpatient reimbursement rate. Conclusions Potential substitution from the outpatient setting to the inpatient setting does not pose a serious threat to Medicare's efforts to contain hospital outpatient costs. PMID:23701048

Azaphenalene phthalocyanines: phthalocyanine analogues with six-membered-ring units instead of five-membered-ring units.

PubMed

Shimizu, Soji; Zhu, Hua; Kobayashi, Nagao

2010-09-24

Mixed-condensation reaction of 1,8-naphthalenedicarbonitrile and a 4,5-disubstituted phthalonitrile provided a series of phthalocyanine (Pc) analogues with azaphenalene (AP) moieties in place of the isoindole moieties. Monosubstituted species, APPc, and the two structural isomers of disubstituted species, adj-AP(2)Pc and opp-AP(2)Pc, were successfully isolated by gel-permeation chromatography on HPLC apparatus. Their structures were elucidated by (1)H NMR spectroscopy and X-ray crystallographic analysis. Replacement of the isoindole moieties with azaphenalene moieties created six-membered-ring units in the core and caused distortion of the molecular structures. The Q-band absorption shifted to the red upon an increase in the number of azaphenalene units; the shape of the absorption spectra depended on the molecular symmetries. APPc and opp-AP(2)Pc showed a large splitting of the Q band, whereas adj-AP(2)Pc exhibited a single broad Q band. These changes in the absorption spectra, as well as the unique electronic structures, are discussed in detail, based on magnetic circular dichroism spectra, electrochemical measurements, and density functional theory calculations.

High-efficiency directional backlight design for an automotive display.

PubMed

Chen, Bo-Tsuen; Pan, Jui-Wen

2018-06-01

We propose a high-efficiency directional backlight module (DBM) for automotive display applications. The DBM is composed of light sources, a light guide plate (LGP), and an optically patterned plate (OPP). The LGP has a collimator on the input surface that serves to control the angle of the light emitted to be in the horizontal direction. The OPP has an inverse prism to adjust the light emission angle in the vertical direction. The DBM has a simple structure and high optical efficiency. Compared with conventional backlight systems, the DBM has higher optical efficiency and a suitable viewing angle. This is an improvement in normalized on-axis luminous intensity of 2.6 times and a twofold improvement in optical efficiency. The viewing angles are 100° in the horizontal direction and 35° in the vertical direction. The angle of the half-luminous intensity is 72° in the horizontal direction and 20° in the vertical direction. The uniformity of the illuminance reaches 82%. The DBM is suitable for use in the center information displays of automobiles.

36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

Code of Federal Regulations, 2014 CFR

2014-07-01

... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

Code of Federal Regulations, 2013 CFR

2013-07-01

... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

Code of Federal Regulations, 2012 CFR

2012-07-01

... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

Code of Federal Regulations, 2011 CFR

2011-07-01

... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

48 CFR 301.607-78 - Contracting Officer designation of a Program/Project Manager as the Contracting Officer's...

Code of Federal Regulations, 2010 CFR

2010-10-01

... designation of a Program/Project Manager as the Contracting Officer's Technical Representative. 301.607-78... Contracting Officer designation of a Program/Project Manager as the Contracting Officer's Technical... acquisition. However, for those individuals serving as a Program or Project Manager under a FAC-P/PM...

7 CFR 2.30 - Director, Office of Budget and Program Analysis.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Director, Office of Budget and Program Analysis. 2.30... Officers and Agency Heads § 2.30 Director, Office of Budget and Program Analysis. (a) The following... Program Analysis: (1) Serve as the Department's Budget Officer and exercise general responsibility and...

36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

Code of Federal Regulations, 2010 CFR

2010-07-01

... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

New magnetic graphene-based inorganic-organic sol-gel hybrid nanocomposite for simultaneous analysis of polar and non-polar organophosphorus pesticides from water samples using solid-phase extraction.

PubMed

Rashidi Nodeh, Hamid; Wan Ibrahim, Wan Aini; Kamboh, Muhammad Afzal; Sanagi, Mohd Marsin

2017-01-01

A new graphene-based tetraethoxysilane-methyltrimethoxysilane sol-gel hybrid magnetic nanocomposite (Fe 3 O 4 @G-TEOS-MTMOS) was synthesised, characterized and successfully applied in magnetic solid-phase extraction (MSPE) for simultaneous analysis of polar and non-polar organophosphorus pesticides from several water samples. The Fe 3 O 4 @G-TEOS-MTMOS nanocomposite was characterized using Fourier transform-infrared spectroscopy, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy and X-ray diffraction. Separation, determination and quantification were achieved using gas chromatography coupled with micro electron capture detector. Adsorption capacity of the sorbent was calculated using Langmuir equation. MSPE was linear in the range 100-1000 pg mL -1 for phosphamidon and dimethoate, and 10-100 pg mL -1 for chlorpyrifos and diazinon, with limit of detection (S/N = 3) of 19.8, 23.7, 1.4 and 2.9 pg mL -1 for phosphamidon, dimethoate, diazinon and chlorpyrifos, respectively. The LODs obtained is well below the maximum residual level (100 pg mL -1 ) as set by European Union for pesticides in drinking water. Acceptable precision (%RSD) was achieved for intra-day (1.3-8.7%, n = 3) and inter-day (7.6-17.8%, n = 15) analyses. Fe 3 O 4 @G-TEOS-MTMOS showed high adsorption capacity (54.4-76.3 mg g -1 ) for the selected OPPs. No pesticide residues were detected in the water samples analysed. Excellent extraction recoveries (83-105%) were obtained for the spiked OPPs from tap, river, lake and sea water samples. The newly synthesised Fe 3 O 4 @G-TEOS-MTMOS showed high potential as adsorbent for OPPs analysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Data Stewardship throughout the Ocean Research Data Life Cycle

NASA Astrophysics Data System (ADS)

Chandler, Cynthia; Groman, Robert; Allison, Molly; Wiebe, Peter; Glover, David

2013-04-01

The Biological and Chemical Oceanography Data Management Office (BCO-DMO) works in partnership with ocean science investigators to publish data from research projects funded by the Biological and Chemical Oceanography Sections and the Office of Polar Programs Antarctic Organisms & Ecosystems Program (OPP ANT) at the U.S. National Science Foundation. Since 2006, researchers have been contributing data to the BCO-DMO data system, and it has developed into a rich repository of data from ocean, coastal and Great Lakes research programs. The end goals of the BCO-DMO are to ensure preservation of NSF funded project data and to provide open access to those data; achievement of those goals is attained through successful completion of a series of related phases. BCO-DMO has developed an end-to-end data stewardship process that includes all phases of the data life cycle: (1) providing data management advice to investigators during the proposal writing stage; (2) registering their funded project at BCO-DMO; (3) adding data and supporting documentation to the BCO-DMO data repository; (4) providing geospatial and text-based data access systems that support data discovery, access, display, assessment, integration, and export of data resources; (5) exploring mechanisms for exchange of data with complementary repositories; (6) publication of data sets to provide publishers of the peer-reviewed literature with citable references (Digital Object Identifiers) and to encourage proper citation and attribution of data sets in the future and (7) submission of final data sets for preservation in the appropriate long-term data archive. Strategic development of collaborative partnerships with complementary data management organizations is essential to sustainable coverage of the full data life cycle from research proposal through preservation of the final data products. Development and incorporation of controlled vocabularies, domain-specific ontologies and globally unique, persistent identifiers to unambiguously identify resources of interest curated by and available from BCO-DMO have significantly enabled progress toward interoperability with partner systems. Several important components have emerged from early collaborative relationships: (1) identifying a trusted authoritative source of complementary content and the appropriate contact; (2) determining the globally unique, persistent identifier for resources of interest and (3) negotiating the requisite syntactic and semantic exchange systems. An added benefit is the ability to use globally unique, persistent resource identifiers to identify and compare related content in other repositories, thus enabling us to improve the accuracy of content in the BCO-DMO data collection. Results from a recent community discussion at the January 2013 Federation of Earth Science Information Partners (ESIP) meeting will be presented. Mindful of the NSF EarthCube initiative in the United States, the ESIP discussion was an effort to identify commonalities and differences in the way different communities meet the challenges of data stewardship throughout the full data life cycle and to determine any gaps that currently exist. BCO-DMO: http://bco-dmo.org ESIP: http://esipfed.org/

78 FR 46333 - Product Cancellation Order for Certain Pesticide Registrations; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... 20460-0001. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305-5805. Please review the visitor instructions and additional...

77 FR 47351 - Notification of Submission to the Secretaries of Agriculture and Health and Human Services...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

... Bldg., Rm. 3334, 1301 Constitution Ave. NW., Washington, DC 20460-0001. The Public Reading Room is open... the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305- 5805. Please review the visitor instructions and additional information about the docket available at...

78 FR 72879 - Product Cancellation Order for Certain Pesticide Registrations; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-04

..., DC 20460-0001. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305- 5805. Please review the visitor instructions and...

75 FR 11173 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various Commodities; Correction... identification No. EPA-HQ-OPP-2009-0980 proposing to establish import tolerances in 40 CFR part 180 for residues of the ``insecticide'' fluazifop-p-butyl in various potato commodities. This document is being issued...

76 FR 22096 - Federal Plan for Certification of Applicators of Restricted Use Pesticides Within EPA Region 8...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0792; FRL-8855-8] Federal Plan for Certification... of R8 Indian country where no other EPA-approved plan applies and on its Proposed Federal Plan for Certification of Applicators of Restricted Use Pesticides within EPA Region 8 Indian Country (Plan). A separate...

75 FR 13285 - Centers for Disease Control and Prevention; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0194; FRL-8814-9] Centers for Disease Control and... (CBI) by the submitter, will be transferred to the Centers for Disease Control and Prevention in accordance with 40 CFR 2.309(c) and 2.308(h)(2). The Centers for Disease Control and Prevention will perform...

75 FR 28608 - Calcium Hydroxide; Receipt of Application for Emergency Exemption, Solicitation of Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0411; FRL-8826-7] Calcium Hydroxide; Receipt of... Department of Agriculture to use the pesticide calcium hydroxide (CAS No. 1305-62-0) to treat up to 1,000...: [email protected] . SUPPLEMENTARY INFORMATION: I. General Information A. Does this Action Apply to Me...

78 FR 25416 - Information Collection Request: Web-Based Supply Chain Management Commodity Offer Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... Request: Web-Based Supply Chain Management Commodity Offer Forms AGENCY: Farm Service Agency and Commodity..., and yearly bases. Special invitations, however, are issued throughout the month. Web-Based Supply... will be posted to the FSA Web site and also to the WBSCM portal and FedBizOpps ( https://www.fbo.gov...

77 FR 42723 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... Environmental Research Involving Human Subjects; EPA ICR No. 2195.04, OMB Control No. 2070-0169. This is a...-OPP- 2011-0704, to (1) EPA online using http://www.regulations.gov (our preferred method), or by mail..., Confidential Business Information (CBI), or other information whose public disclosure is restricted by statute...

77 FR 47287 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

..., is available either electronically through http://www.regulations.gov or in hard copy at the OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the online instructions for...

78 FR 16500 - Rolling Bay, LLC and Indus; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

... contract to perform work for OPP, and access to this information will enable Rolling Bay, LLC and its subcontractor, Indus, to fulfill the obligations of the contract. DATES: Rolling Bay, LLC and its subcontractor... Under Contract No. GS-35F-0072Y, Rolling Bay, LLC and its subcontractor, Indus, will: Capture data that...

77 FR 15015 - Revocation of Tolerance Exemptions for Diethyl Phthalate and Methyl Ethyl Ketone; No Data Being...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

... use of profanity or personal threats. viii. Make sure to submit your comments by the comment period... when used as inert ingredients in pesticide products because there are insufficient data to make the..., 2012. ADDRESSES: Submit your comments, identified by docket identification (ID) number EPA-HQ-OPP-2011...

Identification and Initial Screening of New Compounds to Control Harmful Algal Blooms

DTIC Science & Technology

2006-08-01

industry, the U.S. Department of Agriculture (USDA) IR-4 Project ( minor use pesticides), and the USEPA-OPP to discuss the lack of alternatives for...duckweed, Lemna gibba L. Environmental Toxicology 20: 67-73. ERDC/TN ANSRP-06-2 August 2006 7 Lam, A. K.-Y., and E. E. Prepas. 1997. In situ

77 FR 15012 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

... Pennsylvania Ave. NW., Washington, DC 20460-0001. Delivery: OPP Regulatory Public Docket (7502P), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA. Deliveries... through Friday, excluding legal holidays). Special arrangements should be made for deliveries of boxed...

77 FR 12740 - Trinexapac-ethyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed..., Sugarcane, and Grasses Grown for Seed'' p. 48 in docket ID number EPA-HQ-OPP-2010-0524. B. Toxicological...

78 FR 24738 - Ethylene Oxide; Receipt of Application for Emergency Exemption, Solicitation of Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2013-0276; FRL-9385-2] Ethylene Oxide; Receipt of... ethylene oxide (CAS No. 75-21-8) to sterilize the interior surfaces of enclosed animal isolator units to... APHIS has requested the EPA Administrator to issue a quarantine exemption for the use of ethylene oxide...

75 FR 55786 - Office of Special Education Programs, Office of Special Education and Rehabilitative Services...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... DEPARTMENT OF EDUCATION Office of Special Education Programs, Office of Special Education and Rehabilitative Services, Department of Education; Notice of Final Extension of Project Period and Waiver for the... Transition Technical Assistance Center (NSTTAC). Currently, the Office of Special Education Programs (OSEP...

Research and technology operating plan summary: Fiscal year 1975 research and technology program. [space programs, energy technology, and aerospace sciences

NASA Technical Reports Server (NTRS)

1975-01-01

Summaries are presented of Research and Technology Operating Plans currently in progress throughout NASA. Citations and abstracts of the operating plans are presented along with a subject index, technical monitor index, and responsible NASA organization index. Research programs presented include those carried out in the Office of Aeronautics and Space Technology, Office of Energy Programs, Office of Applications, Office of Space Sciences, Office of Tracking and Data Acquisition, and the Office of Manned Space Flight.

Understanding the Importance and Practice of Credible Leadership at Program Executive Office Ground Combat Systems (PEO GCS) and Program Executive Office Combat Support and Combat Service Support (PEO CS and CSS)

DTIC Science & Technology

2017-03-30

and Program Executive Office Combat Support and Combat Service Support (PEO CS&CSS) Chad P. Stocker March 30, 2017 Submitted to...to Defense Acquisition University in partial fulfillment of the requirement of the Senior Service College Fellowship CREDIBLE LEADERSHIP AT PEO...of Credible Leadership at Program Executive Office Ground Combat Systems (PEO GCS) and Program Executive Office Combat Support and Combat Service

7 CFR 2.74 - Director, Climate Change Program Office.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Director, Climate Change Program Office. 2.74 Section... Director, Climate Change Program Office. (a) Delegations. Pursuant to § 2.29(a)(12), the following delegations of authority are made by the Chief Economist to the Director, Climate Change Program Office: (1...

75 FR 22391 - Notice of Web Site Publication for the Climate Program Office

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

...-01] Notice of Web Site Publication for the Climate Program Office AGENCY: Climate Program Office (CPO... its Web site at http://www.climate.noaa.gov . FOR FURTHER INFORMATION CONTACT: Eric Locklear; Chief... information is available on the Climate Program Office Web site pertaining to the CPO's research strategies...

7 CFR 2.501 - Director, Office of Budget and Program Analysis.

Code of Federal Regulations, 2011 CFR

2011-01-01

... authority are made by the Chief Financial Officer to the Director, Office of Budget and Program Analysis: (1... 7 Agriculture 1 2011-01-01 2011-01-01 false Director, Office of Budget and Program Analysis. 2.501... OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Financial...

40 CFR 136.5 - Approval of alternate test procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303... to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303), Office... will be forwarded to the Alternate Test Procedure Program Coordinator, Office of Science and Technology...

40 CFR 136.5 - Approval of alternate test procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... and to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303... to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303), Office... will be forwarded to the Alternate Test Procedure Program Coordinator, Office of Science and Technology...

75 FR 13125 - Pet Spot-On Analysis and Mitigation Plan Available for Public Comment; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0229; FRL-8816-8] Pet Spot-On Analysis and... registered pet spot-on products to control fleas and ticks and a mitigation plan. The analysis consists of a Technical Review Document and Data Evaluation Records for pet spot-on products. The Agency is requesting...

76 FR 52952 - Student Services Contract EP-11-D-000403 Yin Gu; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8884-1] Student Services Contract EP-11... Business Information (CBI) by the submitter, will be transferred to Student Services Contract EP- 11-D-000403 Yin Gu in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). Student Services Contract EP-11-D...

75 FR 4817 - Beauveria Bassiana Strain GHA; Notice of Receipt of a Request for an Amendment to Delete a Use in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0029; FRL-8809-2] Beauveria Bassiana Strain GHA; Notice of Receipt of a Request for an Amendment to Delete a Use in a Pesticide Registration AGENCY... Beauveria bassiana Tomato Strain GHA Users of this product who desire continued use on the crop being...

76 FR 550 - Second National Bed Bug Summit; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0190; FRL-8858-4] Second National Bed Bug Summit... planning the second National Bed Bug Summit to be held February 1 and 2, 2011, on the topic of the bed bug resurgence in the United States. The goal of this meeting is to review the current bed bug problem and...

76 FR 53910 - Fee for Using a Priority Review Voucher in Fiscal Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... ordinarily takes 10 months into 6 months, OPP estimates that a multiplier of 1.67 (10 months divided by 6... FY 2010. Dividing $6,856,000 (rounded to the nearest thousand dollars) by 13 (the total number of... adjust the FY 2010 cost figure above by the average amount by which FDA's average salary and benefit...

77 FR 56649 - Fee for Using a Priority Review Voucher in Fiscal Year 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... months, OPP estimates that a multiplier of 1.67 (10 months divided by 6 months) should be applied to non... which FDA's average salary and benefit costs increased in the 3 years prior to FY 2012, to adjust the FY... that requests a street address, the courier can deliver the checks to: U.S. Bank, Attention: Government...

Exposing the Impact of Opp(reg)ressive Policies on Teacher Development and on Student Learning

ERIC Educational Resources Information Center

Rodriguez, Alberto J.

2010-01-01

This case study draws attention to Pedro's story, a Grade 6 Latino teacher who, along with other grade 4-6 teachers, participated in a three-year professional development research project. By using data analyzed from multiple ethnographic interviews with teachers and students, and by drawing from the quantitative analyzes of concept map unit…

78 FR 15949 - Notice of Receipt of Request To Voluntarily Cancel Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

... identification (ID) number EPA-HQ-OPP-2006-0955, by one of the following methods: Federal eRulemaking Portal... the disk or CD-ROM the specific information that is claimed as CBI. In addition to one complete... name Chemical name 8845-39 Rid-A-Rat and Mouse Warfarin. Killer. 8845-125 Hot Shot Sudden Death...

76 FR 55814 - 2,4-D; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2010-0905; FRL-8881-7] 2,4-D... regulation establishes tolerances for residues of 2,4-D in or on teff, bran; teff, forage; teff, grain; and... 408(d)(3) of FFDCA, 21 U.S.C. 346a(d)(3), announcing the filing of a pesticide petition (PP 0F7796) by...

76 FR 20667 - Notice of Withdrawal of Pesticide Petitions for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... pesticide petition (PP 8F7489) by EcoSmart Technologies, Inc., 3600 Mansell Rd., Suite 150, Alpharetta, GA... agricultural commodities. On March 9, 2010, EcoSmart Technologies, Inc., notified EPA that it was withdrawing...-HQ-OPP-2010-0092), which announced the filing of a pesticide petition (PP 9F7587) by Technology...

Evaluation of p-phenylenediamine, o-phenylphenol sodium salt, and 2,4-diaminotoluene in the rat comet assay as part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay.

PubMed

De Boeck, Marlies; van der Leede, Bas-jan; De Vlieger, Kathleen; Geys, Helena; Vynckier, An; Van Gompel, Jacky

2015-07-01

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay (comet assay), p-phenylenediamine dihydrochloride (PPD), o-phenylphenol sodium salt (OPP), and 2,4-diaminotoluene (2,4-DAT), were analyzed in this laboratory as coded test chemicals. Male Sprague-Dawley rats (7-9 weeks of age) were given three oral doses of the test compounds, 24 and 21 h apart and liver and stomach were sampled 3h after the final dose administration. Under the conditions of the test, no increases in DNA damage were observed in liver and stomach with PPD and OPP up to 100 and 1000 mg/kg/day, respectively. 2,4-DAT, a known genotoxic carcinogen, induced a weak but reproducible, dose-related and statistically significant increase in DNA damage in liver cells while no increases were observed in stomach cells. Copyright © 2015 Elsevier B.V. All rights reserved.

Quantitative 31P NMR for Simultaneous Trace Analysis of Organophosphorus Pesticides in Aqueous Media Using the Stir Bar Sorptive Extraction Method

NASA Astrophysics Data System (ADS)

Ansari, S.; Talebpour, Z.; Molaabasi, F.; Bijanzadeh, H. R.; Khazaeli, S.

2016-09-01

The analysis of pesticides in water samples is of primary concern for quality control laboratories due to the toxicity of these compounds and their associated public health risk. A novel analytical method based on stir bar sorptive extraction (SBSE), followed by 31P quantitative nuclear magnetic resonance (31P QNMR), has been developed for simultaneously monitoring and determining four organophosphorus pesticides (OPPs) in aqueous media. The effects of factors on the extraction efficiency of OPPs were investigated using a Draper-Lin small composite design. An optimal sample volume of 4.2 mL, extraction time of 96 min, extraction temperature of 42°C, and desorption time of 11 min were obtained. The results showed reasonable linearity ranges for all pesticides with correlation coefficients greater than 0.9920. The limit of quantification (LOQ) ranged from 0.1 to 2.60 mg/L, and the recoveries of spiked river water samples were from 82 to 94% with relative standard deviation (RSD) values less than 4%. The results show that this method is simple, selective, rapid, and can be applied to other sample matrices.

Inhalation Exposure of Organophosphate Pesticides by Vegetable Growers in the Bang-Rieng Subdistrict in Thailand

PubMed Central

Jaipieam, Somsiri; Visuthismajarn, Parichart; Siriwong, Wattasit; Borjan, Marija; Robson, Mark G.

2009-01-01

This study investigated inhalation exposure to organophosphate pesticides (OPPs) and evaluated the associated health risks to vegetable growers living in the Bang-Rieng agricultural community. Air samples were collected by using personal sampling pumps with sorbent tubes placed in the vegetable growers' breathing zone. Samples were collected during both wet and dry seasons. Residues of organophosphate pesticides, that is, chlorpyrifos, dicrotofos, and profenofos, were analyzed from 33 vegetable growers and 17 reference subjects. Results showed that median concentrations of OPPs in air in farm areas were in the range of 0.022–0.056 mg/m3 and air in nonfarm areas in the range of <0.0016–<0.005 mg/m3. The concentration of the three pesticides in the vegetable growers was significantly higher than that of the references during both seasons. The results also indicate that the vegetable growers may be at risk for acute adverse effects via the inhalation of chlorpyrifos and dicrotofos during pesticide application, mixing, loading, and spraying. It is suggested that authorities and the community should implement appropriate strategies concerning risk reduction and risk management. PMID:20168980

The Repeated Name Penalty, the Overt Pronoun Penalty, and Topic in Japanese.

PubMed

Shoji, Shinichi; Dubinsky, Stanley; Almor, Amit

2017-02-01

When reading sentences with an anaphoric reference to a subject antecedent, repeated-name anaphors result in slower reading times relative to pronouns (the Repeated Name Penalty: RNP), and overt pronouns are read slower than null pronouns (the Overt Pronoun Penalty: OPP). Because in most languages previously tested, the grammatical subject is typically also the discourse topic it remains unclear whether these effects reflect anaphors' subject-hood or their topic-hood. To address this question we conducted a self-paced reading experiment in Japanese, a language which morphologically marks both subjects and topics overtly. Our results show that both repeated-name topic-subject anaphors and repeated-name non-topic-subject anaphors exhibit the RNP and that both overt-pronoun topic-subject and overt-pronoun non-topic-subject anaphors show the OPP. However, a detailed examination of performance revealed an interaction between the anaphor topic marking, reference form, and the antecedent's grammatical status, indicating that the effect of the antecedent's grammatical status is strongest for null pronoun and repeated name subject anaphors and that the overt form most similar to null pronouns is the repeated name topic anaphor. We discuss the implications of these findings for theories of anaphor processing.

A Survey of 42 Semi-Volatile Organic Contaminants in Groundwater along the Grand Canal from Hangzhou to Beijing, East China.

PubMed

Li, Xiaojie; Rao, Zhu; Yang, Zhipeng; Guo, Xiaochen; Huang, Yi; Zhang, Jing; Guo, Feng; Liu, Chen

2015-12-18

The status of organic pollution in groundwater in eastern China along the Grand Canal from Hangzhou to Beijing was evaluated. Forty-two semi-volatile organic contaminants were analyzed, including 16 polycyclic aromatic hydrocarbons (PAHs), seven polychlorinated biphenyls (PCBs), 12 organochlorine pesticides (OCPs) and seven organophosphorus pesticides (OPPs). Among the detected contaminants, PAHs were the most widespread compounds. One PCB and six OCPs were detected in the groundwater samples, but none of the target OPPs was detected. The total concentration of the 16 PAHs ranged from 0.21 to 1006 ng/L, among which phenanthrene (271 ng/L) and fluoranthene (233 ng/L) were present at very high concentrations and naphthalene (32 positive detections in 50 samples) and fluorene (28 detections in 50 samples) were the most frequently detected. Benzo[a]pyrene equivalents indicated a high environmental risk related to PAHs in a few groundwater samples. To identify the possible sources of PAHs, three concentration ratios, low molecular weight PAHs/high molecular weight PAHs, anthracene/(anthracene + phenanthrene) and fluoranthene/(fluoranthene + pyrene), were determined, that indicated that the PAHs mainly originated from mixed sources: pyrolytic and petrogenic sources with different ratios at different sites.

Development of antioxidant food packaging materials containing eugenol for extending display life of fresh beef.

PubMed

Navikaite-Snipaitiene, Vesta; Ivanauskas, Liudas; Jakstas, Valdas; Rüegg, Nadine; Rutkaite, Ramune; Wolfram, Evelyn; Yildirim, Selçuk

2018-05-23

In this study, clove essential oil (CL) or eugenol (EU) containing cellulose acetate (CA) or acrylic component/hydrophobically modified starch (AC/S) coatings on corona treated oriented polypropylene film (OPP) were designed and investigated for their possible applications as antioxidant packaging materials for fresh meat. The antioxidant properties of the coatings were investigated by Vapour Phase-DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. The CA coatings containing CL or EU showed 43-92% and 43-94% inhibition against DPPH free radicals through the vapour phase, respectively, whereas AC/S/CL and AC/S/EU coatings resulted in DPPH inhibition of 21-65% and 25-84%, respectively. AC/S/EU and CA/EU coatings on OPP containing from 0.32 ± 0.03 to 6.40 ± 0.14 g/m 2 of EU were used to prepare packaging for fresh beef (Longissimus thoracis). After 14 days, the lipid oxidation in beef steaks kept in control and antioxidant packages was 3.33 and 1.00-1.22 mg of malondialdehyde per kilogram of meat, respectively. Moreover, red colour of beef in antioxidant packages was retained. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Survey of 42 Semi-Volatile Organic Contaminants in Groundwater along the Grand Canal from Hangzhou to Beijing, East China

PubMed Central

Li, Xiaojie; Rao, Zhu; Yang, Zhipeng; Guo, Xiaochen; Huang, Yi; Zhang, Jing; Guo, Feng; Liu, Chen

2015-01-01

The status of organic pollution in groundwater in eastern China along the Grand Canal from Hangzhou to Beijing was evaluated. Forty-two semi-volatile organic contaminants were analyzed, including 16 polycyclic aromatic hydrocarbons (PAHs), seven polychlorinated biphenyls (PCBs), 12 organochlorine pesticides (OCPs) and seven organophosphorus pesticides (OPPs). Among the detected contaminants, PAHs were the most widespread compounds. One PCB and six OCPs were detected in the groundwater samples, but none of the target OPPs was detected. The total concentration of the 16 PAHs ranged from 0.21 to 1006 ng/L, among which phenanthrene (271 ng/L) and fluoranthene (233 ng/L) were present at very high concentrations and naphthalene (32 positive detections in 50 samples) and fluorene (28 detections in 50 samples) were the most frequently detected. Benzo[a]pyrene equivalents indicated a high environmental risk related to PAHs in a few groundwater samples. To identify the possible sources of PAHs, three concentration ratios, low molecular weight PAHs/high molecular weight PAHs, anthracene/(anthracene + phenanthrene) and fluoranthene/(fluoranthene + pyrene), were determined, that indicated that the PAHs mainly originated from mixed sources: pyrolytic and petrogenic sources with different ratios at different sites. PMID:26694442

Biosensors Fabricated through Electrostatic Assembly of Enzymes/Polyelectrolyte Hybrid Layers on Carbon Nanotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Yuehe; Liu, Guodong; Wang, Jun

2006-06-01

Carbon nanotubes (CNTs) have emerged as new class of nanomaterials that is receiving considerable interest because of their unique structure, mechanical, and electronic properties. One promising application of CNTs is to fabricate highly sensitive chemo/biosensors.1-4 For construction of these CNT-based sensors, the CNTs first have to be modified with some molecules specific to the interests. Generally, covalent binding, affinity, and electrostatic interaction have been utilized for the modification of CNTs. Among them, the electrostatic method is attractive due to its simplicity and high efficiency. In present work, we have developed highly sensitively amperometric biosensors for glucose, choline, organophosphate pesticide (OPP)more » and nerve agents (NAs) based on electrostatically assembling enzymes on the surface of CNTs. All these biosensors were fabricated by immobilization of enzymes on the negatively charged CNTs surface through alternately assembling a cationic poly(diallydimethylammonium chloride) (PDDA) layer and an enzyme layer. Using this layer-by-layer (LBL) technique, a bioactive nanocomposite film was fabricated on the electrode surface. Owing to the electrocatalytic effect of CNTs, an amplified electrochemical signal was achieved, which leads to low detections limits for glucose, choline, and OPP and NAs.« less

Comparison of Program Activities and Lessons Learned among 19 School Resource Officer (SRO) Programs. Document Number 209272

ERIC Educational Resources Information Center

Finn, Peter; Shively, Michael; McDevitt, Jack; Lassiter, William; Rich, Tom

2005-01-01

There has been growing interest in placing sworn law enforcement officers in schools as School Resource Officers (SROs) to improve school safety and improve relations between police officers and youth. The purpose of this National Assessment was to identify what program "models" have been implemented, how programs have been implemented, and what…

20 CFR 701.201 - Office of Workers' Compensation Programs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Office of Workers' Compensation Programs. 701.201 Section 701.201 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR...; DEFINITIONS AND USE OF TERMS Office of Workers' Compensation Programs § 701.201 Office of Workers...

Secretary's report to Congress. Secretary's statement, program review and outlook

NASA Astrophysics Data System (ADS)

1982-08-01

All elements of the Department of Energy are discussed. Three annexes are included: the Fifth Report to Congress - Comprehensive Program and Plan for Federal Energy Education, Extension, and Information Activities (Published December 1981 by the Office of State and Local Programs, Office of Conservation and Renewable Energy, US Department of Energy); Third Annual Report to Congress on the Automotive Technology Development Program (Published February 16, 1982, by the Office of Vehicle and Engine Research and Development, Office of Conservation and Renewable Energy,US Department of Energy); and Observations and Recommendations on the Future of the Energy Extension Service Program; Fourth Report by the National Energy Extension Service Advisory Board (Published January 182 by the Office of State and Local Programs, Office of Conservation and Renewable Energy, US Department of Energy).

28 CFR 90.104 - What must the grant program application contain?

Code of Federal Regulations, 2010 CFR

2010-07-01

... contain? 90.104 Section 90.104 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) VIOLENCE AGAINST... Office of the Office of Justice Programs. The Violence Against Women Office of the Office of Justice... Justice Programs, 810 Seventh Street, N.W., Washington, D.C. 20531. Telephone: (202) 307-6026. (b...

76 FR 1641 - Agency Information Collection Activities: Proposed Collection; Comments Requested

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

... DEPARTMENT OF JUSTICE Office of Justice Programs Office for Victims of Crime [OMB Number 1121-0114... Crime Act, Victim Compensation Grant Program, State Performance Report. The Department of Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC), will be submitting the following...

78 FR 3474 - Privacy Act of 1974; Computer Matching Program Between the Office Of Personnel Management and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... Security benefit information to OPM via direct computer link for the administration of certain programs by... OFFICE OF PERSONNEL MANAGEMENT Privacy Act of 1974; Computer Matching Program Between the Office Of Personnel Management and Social Security Administration AGENCY: Office of Personnel Management...

40 CFR 1.49 - Office of Water.

Code of Federal Regulations, 2011 CFR

2011-07-01

... programs, is responsible for management of EPA's water programs. Functions of the Office include program... assistance to the regional activities in both enforcement and permitting programs. (b) Office of Water... for monitoring and evaluating the performance, progress, and fiscal status of the organization in...

40 CFR 1.49 - Office of Water.

Code of Federal Regulations, 2010 CFR

2010-07-01

... programs, is responsible for management of EPA's water programs. Functions of the Office include program... assistance to the regional activities in both enforcement and permitting programs. (b) Office of Water... for monitoring and evaluating the performance, progress, and fiscal status of the organization in...

14 CFR 91.1017 - Amending program manager's management specifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... proposed amendment. (2) The Flight Standards District Office that issued the program manager's management... presented, the Flight Standards District Office that issued the program manager's management specifications... Standards District Office that issued the program manager's management specifications issues an amendment of...

14 CFR 91.1017 - Amending program manager's management specifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... proposed amendment. (2) The Flight Standards District Office that issued the program manager's management... presented, the Flight Standards District Office that issued the program manager's management specifications... Standards District Office that issued the program manager's management specifications issues an amendment of...

32 CFR 2400.41 - Office Review Committee.

Code of Federal Regulations, 2014 CFR

2014-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.41 Office Review...

32 CFR 2400.41 - Office Review Committee.

Code of Federal Regulations, 2012 CFR

2012-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.41 Office Review...

32 CFR 2400.41 - Office Review Committee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.41 Office Review...

32 CFR 2400.41 - Office Review Committee.

Code of Federal Regulations, 2011 CFR

2011-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.41 Office Review...

32 CFR 2400.41 - Office Review Committee.

Code of Federal Regulations, 2013 CFR

2013-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.41 Office Review...

Syphilis

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

77 FR 28887 - Office of the Director, National Institutes of Health, Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment... Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from.../Outreach Program Specialist, Office of Communications and Public Liaison, Office of the Director, National...

75 FR 63493 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment... Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from..., Executive Secretary/Outreach Program Specialist, Office of Communications and Public Liaison, Office of the...

Tickborne Diseases

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

Tuberculosis (TB)

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

5 CFR Appendix C to Subpart D of... - Application of Subpart D, Part 900, to Programs Receiving Federal Financial Assistance of the...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Programs Receiving Federal Financial Assistance of the Office of Personnel Management C Appendix C to... Programs Receiving Federal Financial Assistance of the Office of Personnel Management Nondiscrimination in... subpart in programs receiving financial assistance under programs of the Office of Personnel Management...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins

PubMed Central

Ren, Dabin; Murphy, Timothy F.; Lafontaine, Eric R.; Pichichero, Michael E.

2017-01-01

Moraxella catarrhalis (Mcat) is a prominent mucosal pathogen causing acute otitis media (AOM). We studied Mcat nasopharyngeal (NP) colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP) CD, oligopeptide permease (Opp) A, hemagglutinin (Hag), and Pilin A clade 2 (PilA2) from stringently defined otitis prone (sOP) children, who experience the greatest burden of disease, compared to non-otitis prone (NOP) children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P = 0.0003) and Mcat-caused AOM rates (49 vs. 24%, P < 0.0001) than NOP children. Natural acquisition of mucosal antibodies to Mcat proteins OMP CD (IgG, P < 0.0001), OppA (IgG, P = 0.018), Hag (IgG and IgA, both P < 0.0001), and PilA2 (IgA, P < 0.0001) was lower in sOP than NOP children. Higher levels of mucosal IgG to Hag (P = 0.039) and PilA2 (P = 0.0076), and IgA to OMP CD (P = 0.010), OppA (P = 0.030), and PilA2 (P = 0.043) were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD (P = 0.0070) and Hag (P = 0.0003), and IgA to Hag (P = 0.0067) at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P < 0.0001). In conclusion, sOP children had a diminished mucosal antibody response to Mcat proteins, which was associated with higher frequencies of asymptomatic NP colonization and NP colonization progressing to Mcat-caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children. PMID:28848555

Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins.

PubMed

Ren, Dabin; Murphy, Timothy F; Lafontaine, Eric R; Pichichero, Michael E

2017-01-01

Moraxella catarrhalis ( Mcat ) is a prominent mucosal pathogen causing acute otitis media (AOM). We studied Mcat nasopharyngeal (NP) colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP) CD, oligopeptide permease (Opp) A, hemagglutinin (Hag), and Pilin A clade 2 (PilA2) from stringently defined otitis prone (sOP) children, who experience the greatest burden of disease, compared to non-otitis prone (NOP) children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P  = 0.0003) and Mcat -caused AOM rates (49 vs. 24%, P  < 0.0001) than NOP children. Natural acquisition of mucosal antibodies to Mcat proteins OMP CD (IgG, P  < 0.0001), OppA (IgG, P  = 0.018), Hag (IgG and IgA, both P  < 0.0001), and PilA2 (IgA, P  < 0.0001) was lower in sOP than NOP children. Higher levels of mucosal IgG to Hag ( P  = 0.039) and PilA2 ( P  = 0.0076), and IgA to OMP CD ( P  = 0.010), OppA ( P  = 0.030), and PilA2 ( P  = 0.043) were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD ( P  = 0.0070) and Hag ( P  = 0.0003), and IgA to Hag ( P  = 0.0067) at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P  < 0.0001). In conclusion, sOP children had a diminished mucosal antibody response to Mcat proteins, which was associated with higher frequencies of asymptomatic NP colonization and NP colonization progressing to Mcat -caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children.

5 CFR 2600.103 - Office of Government Ethics organization and functions.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) The Office of Administration and Information Management. (b) Office of the Director. The Director of... certain aspects of agency ethics programs. (f) Office of Administration and Information Management. The Office of Administration and Information Management provides support to all OGE operating programs...

5 CFR 2600.103 - Office of Government Ethics organization and functions.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) The Office of Administration and Information Management. (b) Office of the Director. The Director of... certain aspects of agency ethics programs. (f) Office of Administration and Information Management. The Office of Administration and Information Management provides support to all OGE operating programs...

5 CFR 2600.103 - Office of Government Ethics organization and functions.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) The Office of Administration and Information Management. (b) Office of the Director. The Director of... certain aspects of agency ethics programs. (f) Office of Administration and Information Management. The Office of Administration and Information Management provides support to all OGE operating programs...

5 CFR 2600.103 - Office of Government Ethics organization and functions.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) The Office of Administration and Information Management. (b) Office of the Director. The Director of... certain aspects of agency ethics programs. (f) Office of Administration and Information Management. The Office of Administration and Information Management provides support to all OGE operating programs...

The FITS model office ergonomics program: a model for best practice.

PubMed

Chim, Justine M Y

2014-01-01

An effective office ergonomics program can predict positive results in reducing musculoskeletal injury rates, enhancing productivity, and improving staff well-being and job satisfaction. Its objective is to provide a systematic solution to manage the potential risk of musculoskeletal disorders among computer users in an office setting. A FITS Model office ergonomics program is developed. The FITS Model Office Ergonomics Program has been developed which draws on the legislative requirements for promoting the health and safety of workers using computers for extended periods as well as previous research findings. The Model is developed according to the practical industrial knowledge in ergonomics, occupational health and safety management, and human resources management in Hong Kong and overseas. This paper proposes a comprehensive office ergonomics program, the FITS Model, which considers (1) Furniture Evaluation and Selection; (2) Individual Workstation Assessment; (3) Training and Education; (4) Stretching Exercises and Rest Break as elements of an effective program. An experienced ergonomics practitioner should be included in the program design and implementation. Through the FITS Model Office Ergonomics Program, the risk of musculoskeletal disorders among computer users can be eliminated or minimized, and workplace health and safety and employees' wellness enhanced.

76 FR 16000 - Voluntary Protection Programs Information; Extension of the Office of Management and Budget's...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... management programs including how the programs successfully address management leadership and employee...] Voluntary Protection Programs Information; Extension of the Office of Management and Budget's (OMB's... concerning its proposal to extend the Office of Management and Budget's (OMB's) approval of the information...

78 FR 15022 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

... Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for... Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds..., Director of Scientific and Program Operations, Office of Aids Research, Office of the Director, NIH, 5635...

Primary Immune Deficiency Diseases

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

Wiskott-Aldrich Syndrome (WAS)

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Respiratory Syncytial Virus (RSV): Treatment

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Rocky Mountain Spotted Fever

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75 FR 42745 - Production Incentives for Cellulosic Biofuels: Notice of Program Intent

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2010-07-22

... gives notice that the Office of Biomass Program, in the Office of Energy Efficiency and Renewable Energy...: Questions may be directed to: Mr. Neil Rossmeissl, Office of the Biomass Program, U.S. Department of Energy...

DON Mentor-Protege Program

DTIC Science & Technology

2011-08-23

The HCA Small Business Office should forward endorsed agreements for evaluation to the Mentor-Protégé Program Manager for final review by close of...PROGRAM MANAGER Oreta Stinson Small Business Programs Office of the Secretary of the Navy 720 Kennon Ave S.E. Building 36, Room 207 Washington...DON Mentor-Protégé Program August 23, 2011 Oreta Stinson Deputy Director, Department of the Navy Office of Small Business Programs Report

National Institute of Allergy and Infectious Diseases

MedlinePlus

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Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome (WHIMS)

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

Types of HIV/AIDS Antiretroviral Drugs

MedlinePlus

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Program and Management Support for the Office of Military Performance Assessment Technology

DTIC Science & Technology

1991-04-30

AD-A242 819 AD PROGRAM AND MANAGEMENT SUPPORT FOR THE OFFICE OF MILITARY PERFORMANCE ASSESSMENT TECHNOLOGY ANNUAL REPORT MARVIN FITTS APRIL 30, 1991...1991 Annual 8 Mar 90 - 7 Mar 91 Program and Management Support for the Office of DAMD17-90-C-0061 Military Performance Assessment Technology Marvin...Reporting period: 08 March 1990 - 7 March 1991 5. Project Title: Program and Management Support for the Office of Military Performance Assessment

The Socioeconomic Benefit to Individuals of Achieving the 2020 Targets for Five Preventive Chemotherapy Neglected Tropical Diseases.

PubMed

Redekop, William K; Lenk, Edeltraud J; Luyendijk, Marianne; Fitzpatrick, Christopher; Niessen, Louis; Stolk, Wilma A; Tediosi, Fabrizio; Rijnsburger, Adriana J; Bakker, Roel; Hontelez, Jan A C; Richardus, Jan H; Jacobson, Julie; de Vlas, Sake J; Severens, Johan L

2017-01-01

Lymphatic filariasis (LF), onchocerciasis, schistosomiasis, soil-transmitted helminths (STH) and trachoma represent the five most prevalent neglected tropical diseases (NTDs). They can be controlled or eliminated by means of safe and cost-effective interventions delivered through programs of Mass Drug Administration (MDA)-also named Preventive Chemotherapy (PCT). The WHO defined targets for NTD control/elimination by 2020, reinforced by the 2012 London Declaration, which, if achieved, would result in dramatic health gains. We estimated the potential economic benefit of achieving these targets, focusing specifically on productivity and out-of-pocket payments. Productivity loss was calculated by combining disease frequency with productivity loss from the disease, from the perspective of affected individuals. Productivity gain was calculated by deducting the total loss expected in the target achievement scenario from the loss in a counterfactual scenario where it was assumed the pre-intervention situation in 1990 regarding NTDs would continue unabated until 2030. Economic benefits from out-of-pocket payments (OPPs) were calculated similarly. Benefits are reported in 2005 US$ (purchasing power parity-adjusted and discounted at 3% per annum from 2010). Sensitivity analyses were used to assess the influence of changes in input parameters. The economic benefit from productivity gain was estimated to be I$251 billion in 2011-2020 and I$313 billion in 2021-2030, considerably greater than the total OPPs averted of I$0.72 billion and I$0.96 billion in the same periods. The net benefit is expected to be US$ 27.4 and US$ 42.8 for every dollar invested during the same periods. Impact varies between NTDs and regions, since it is determined by disease prevalence and extent of disease-related productivity loss. Achieving the PCT-NTD targets for 2020 will yield significant economic benefits to affected individuals. Despite large uncertainty, these benefits far exceed the investment required by governments and their development partners within all reasonable scenarios. Given the concentration of the NTDs among the poorest households, these investments represent good value for money in efforts to share the world's prosperity and reduce inequity.

The Socioeconomic Benefit to Individuals of Achieving the 2020 Targets for Five Preventive Chemotherapy Neglected Tropical Diseases

PubMed Central

Luyendijk, Marianne; Fitzpatrick, Christopher; Niessen, Louis; Stolk, Wilma A.; Tediosi, Fabrizio; Rijnsburger, Adriana J.; Bakker, Roel; Hontelez, Jan A. C.; Richardus, Jan H.; Jacobson, Julie; de Vlas, Sake J.; Severens, Johan L.

2017-01-01

Background Lymphatic filariasis (LF), onchocerciasis, schistosomiasis, soil-transmitted helminths (STH) and trachoma represent the five most prevalent neglected tropical diseases (NTDs). They can be controlled or eliminated by means of safe and cost-effective interventions delivered through programs of Mass Drug Administration (MDA)—also named Preventive Chemotherapy (PCT). The WHO defined targets for NTD control/elimination by 2020, reinforced by the 2012 London Declaration, which, if achieved, would result in dramatic health gains. We estimated the potential economic benefit of achieving these targets, focusing specifically on productivity and out-of-pocket payments. Methods Productivity loss was calculated by combining disease frequency with productivity loss from the disease, from the perspective of affected individuals. Productivity gain was calculated by deducting the total loss expected in the target achievement scenario from the loss in a counterfactual scenario where it was assumed the pre-intervention situation in 1990 regarding NTDs would continue unabated until 2030. Economic benefits from out-of-pocket payments (OPPs) were calculated similarly. Benefits are reported in 2005 US$ (purchasing power parity-adjusted and discounted at 3% per annum from 2010). Sensitivity analyses were used to assess the influence of changes in input parameters. Results The economic benefit from productivity gain was estimated to be I$251 billion in 2011–2020 and I$313 billion in 2021–2030, considerably greater than the total OPPs averted of I$0.72 billion and I$0.96 billion in the same periods. The net benefit is expected to be US$ 27.4 and US$ 42.8 for every dollar invested during the same periods. Impact varies between NTDs and regions, since it is determined by disease prevalence and extent of disease-related productivity loss. Conclusion Achieving the PCT-NTD targets for 2020 will yield significant economic benefits to affected individuals. Despite large uncertainty, these benefits far exceed the investment required by governments and their development partners within all reasonable scenarios. Given the concentration of the NTDs among the poorest households, these investments represent good value for money in efforts to share the world’s prosperity and reduce inequity. PMID:28103243

76 FR 47228 - Redelegation of Authority to Office of Native American Program (ONAP) Area Office Administrators...

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... Secretary for ONAP to an ONAP Area Office Administrator or other ranking program official. The power and... ranking program official and remains with the Deputy Assistant Secretary for ONAP: 1. Offer new... Administrators or other ranking program officials may further redelegate specific authority. Other redelegated...

77 FR 37284 - Technical Amendments

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... DEPARTMENT OF LABOR Office of Workers' Compensation Programs 20 CFR Parts 701, 702, 703, 725, and 726 RIN 1240-AA05 Technical Amendments AGENCY: Office of Workers' Compensation Programs, Labor. ACTION: Final rule. SUMMARY: The Office of Workers' Compensation Programs is making [[Page 37285

Hyper-Immunoglobulin E Syndrome (HIES) or Job's Syndrome

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... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

75 FR 52768 - National Protection and Programs Directorate; Agency Information Collection Activities: Office of...

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77 FR 47440 - Office of the Assistant Secretary for Office of Disability Employment Program National Center on...

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32 CFR 311.7 - OSD/JS Privacy Office Processes.

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2011-07-01

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32 CFR 311.7 - OSD/JS Privacy Office Processes.

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2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false OSD/JS Privacy Office Processes. 311.7 Section...) PRIVACY PROGRAM OFFICE OF THE SECRETARY OF DEFENSE AND JOINT STAFF PRIVACY PROGRAM § 311.7 OSD/JS Privacy Office Processes. The OSD/JS Privacy Office shall: (a) Exercise oversight and administrative control of...

32 CFR 311.7 - OSD/JS Privacy Office Processes.

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2014-07-01

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32 CFR 311.7 - OSD/JS Privacy Office Processes.

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32 CFR 311.7 - OSD/JS Privacy Office Processes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false OSD/JS Privacy Office Processes. 311.7 Section...) PRIVACY PROGRAM OFFICE OF THE SECRETARY OF DEFENSE AND JOINT STAFF PRIVACY PROGRAM § 311.7 OSD/JS Privacy Office Processes. The OSD/JS Privacy Office shall: (a) Exercise oversight and administrative control of...

48 CFR 719.271-5 - Cognizant technical officers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... officers. 719.271-5 Section 719.271-5 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 719.271-5 Cognizant technical officers... cognizant technical officers can affect the opportunity of small business to participate equitably...

32 CFR 2400.42 - Security Officer.

Code of Federal Regulations, 2011 CFR

2011-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.42 Security...

32 CFR 2400.42 - Security Officer.

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2010-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.42 Security...

32 CFR 2400.42 - Security Officer.

Code of Federal Regulations, 2014 CFR

2014-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.42 Security...

32 CFR 2400.42 - Security Officer.

Code of Federal Regulations, 2013 CFR

2013-07-01

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32 CFR 2400.42 - Security Officer.

Code of Federal Regulations, 2012 CFR

2012-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.42 Security...

Naval Supply Systems Command Fleet Logistics Center

DTIC Science & Technology

2012-08-08

Partial small business set - aside is a potential consideration   12-month Base plus two options   Synopsis N00604-11-R-3006 on NECO and FedBizOpps...2012 Navy Gold Coast Small Business Procurement Event 8 August 2012 #1 PRIORITY = Operating Forces Support …while ensuring Joint...while ensuring Joint Base Success FedBid.com Reverse Auction Website 8 Small Business Assistance #1 PRIORITY = Operating Forces

Navy Lasers, Railgun, and Hypervelocity Projectile: Background and Issues for Congress

DTIC Science & Technology

2016-05-27

surface ships to defend themselves against enemy missiles—solid state lasers (SSLs), the electromagnetic railgun (EMRG), and the hypervelocity... electromagnetic railgun (EMRG), and the hypervelocity projectile (HVP). 1 Any one of these new weapon technologies, if successfully developed and deployed...Number: N00024-15-R-4132, FedBizOpps.gov, July 29, 2015. See also Justin Doubleday, “Navy Developing Integrated Mount For Electromagnetic Railgun

Media Use Patterns of Young Men: Findings from the Youth Attitude Tracking Study 2

DTIC Science & Technology

1990-08-01

advertising avenue for the Military. To use the media most effectively , however, requires knowledge of the attitudes and practices of youths regarding...OPP~ FILE COPY DEFENSE -MANPOWER DATA CENTER MEDIA USE PATTERNS OF YOUNG MEN FINDINGS FROM THE YOUTH ATTITUDE TRACKING STUDY If Market Research...cost- effective military advertising. Understanding media use patterns will provide information to aid in understanding how to target advertising

75 FR 32463 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

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2010-06-08

... CropScience, P.O. Box 12014, 2 T. W. Alexander Drive, Research Triangle Park, NC 27709, proposes to...-5967, e-mail address: [email protected] . 5. PP 0F7706. (EPA-HQ-OPP-2010-0311). Bayer CropScience... commodities poultry, fat at 0.1 ppm; poultry, meat byproducts at 0.1 ppm; poultry, meat at 0.1 ppm; and eggs...

Genetic analysis of the agrocinopine catabolic region of Agrobacterium tumefaciens Ti plasmid pTiC58, which encodes genes required for opine and agrocin 84 transport.

PubMed Central

Hayman, G T; Beck von Bodman, S; Kim, H; Jiang, P; Farrand, S K

1993-01-01

The acc region, subcloned from pTiC58 of classical nopaline and agrocinopine A and B Agrobacterium tumefaciens C58, allowed agrobacteria to grow using agrocinopine B as the sole source of carbon and energy. acc is approximately 6 kb in size. It consists of at least five genes, accA through accE, as defined by complementation analysis using subcloned fragments and transposon insertion mutations of acc carried on different plasmids within the same cell. All five regions are required for agrocin 84 sensitivity, and at least four are required for agrocinopine and agrocin 84 uptake. The complementation results are consistent with the hypothesis that each of the five regions is separately transcribed. Maxicell experiments showed that the first of these genes, accA, encodes a 60-kDa protein. Analysis of osmotic shock fractions showed this protein to be located in the periplasm. The DNA sequence of the accA region revealed an open reading frame encoding a predicted polypeptide of 59,147 Da. The amino acid sequence encoded by this open reading frame is similar to the periplasmic binding proteins OppA and DppA of Escherichia coli and Salmonella typhimurium and OppA of Bacillus subtilis. Images PMID:8366042

Microwave-assisted extraction at atmospheric pressure coupled to different clean-up methods for the determination of organophosphorus pesticides in olive and avocado oil.

PubMed

Fuentes, Edwar; Báez, María E; Díaz, Juan

2009-12-18

An effective extraction method was devised for the determination of organophosphorus pesticides (OPPs) in olive and avocado oil samples, using atmospheric pressure microwave-assisted liquid-liquid extraction (APMAE) and solid-phase extraction or low-temperature precipitation as clean-up step. A simple glass system equipped with an air-cooled condenser was designed as an extraction vessel. The pesticides were partitioned between acetonitrile and oil solution in hexane. Analytical determinations were carried out by gas chromatography-flame photometric detection and gas chromatography-tandem mass spectrometry, using a triple quadrupole mass analyzer, for confirmation purposes. Several factors influencing the extraction efficiency were investigated and optimized through fractional factorial design and Doehlert design. Under optimal conditions the recovery of pesticides from oil at 0.025 microg g(-1) ranged from 71% to 103%, except for fenthion in avocado oil, with RSDs < or = 13% (n=5). The LOQ for the entire method ranged from 0.004 to 0.015 microg g(-1). Finally, the proposed method was successfully applied to the extraction and determination of the selected pesticides in 20 commercially packed extra virgin olive oils and four commercially packed avocado oils produced in Chile. Detectable residues of different OPPs were observed in 85% of samples.

Quality changes of fresh-cut kohlrabi sticks under modified atmosphere packaging.

PubMed

Escalona, V H; Aguayo, E; Artés, F

2007-06-01

The aim of this study was to determine the effect of different gas compositions on quality attributes and shelf life of kohlrabi sticks stored in modified atmosphere up to 14 d at 0 degrees C. Two commercial films were tested: oriented polypropylene (OPP) and amide-polyethylene (amide-PE). As a control, a microperforated OPP film was used. In order to study the changes in metabolic activity by minimal processing, the respiration rate and ethylene production at 0 degrees C were monitored for both intact stems and sticks. Changes in color, chemical parameters, sugars and organic acid contents, and sensorial quality of kohlrabi sticks were evaluated. An initial ethylene production of sticks was 13-fold higher than that of intact stems; meanwhile CO(2) production was 2-fold higher. However after 4 d of storage, a similar respiration rate for stems and sticks was found. Also the ethylene production of sticks and stems was steady around 15 to 20 nL/kg(/)h after 10 d. Kohlrabi sticks showed a little change in chemical parameters and very low weight losses during cold storage. Sticks under an equilibrium atmosphere of 7 kPa O(2) and 9 kPa CO(2) at 0 degrees C reached by amide-PE kept an acceptable sensorial quality for 14 d.

Calculation of Relative Binding Free Energy in the Water-Filled Active Site of Oligopeptide-Binding Protein A.

PubMed

Maurer, Manuela; de Beer, Stephanie B A; Oostenbrink, Chris

2016-04-15

The periplasmic oligopeptide binding protein A (OppA) represents a well-known example of water-mediated protein-ligand interactions. Here, we perform free-energy calculations for three different ligands binding to OppA, using a thermodynamic integration approach. The tripeptide ligands share a high structural similarity (all have the sequence KXK), but their experimentally-determined binding free energies differ remarkably. Thermodynamic cycles were constructed for the ligands, and simulations conducted in the bound and (freely solvated) unbound states. In the unbound state, it was observed that the difference in conformational freedom between alanine and glycine leads to a surprisingly slow convergence, despite their chemical similarity. This could be overcome by increasing the softness parameter during alchemical transformations. Discrepancies remained in the bound state however, when comparing independent simulations of the three ligands. These difficulties could be traced to a slow relaxation of the water network within the active site. Fluctuations in the number of water molecules residing in the binding cavity occur mostly on a timescale larger than the simulation time along the alchemical path. After extensive simulations, relative binding free energies that were converged to within thermal noise could be obtained, which agree well with available experimental data.

Calculation of Relative Binding Free Energy in the Water-Filled Active Site of Oligopeptide-Binding Protein A

PubMed Central

Maurer, Manuela; de Beer, Stephanie B. A.; Oostenbrink, Chris

2018-01-01

The periplasmic oligopeptide binding protein A (OppA) represents a well-known example of water-mediated protein-ligand interactions. Here, we perform free-energy calculations for three different ligands binding to OppA, using a thermodynamic integration approach. The tripeptide ligands share a high structural similarity (all have the sequence KXK), but their experimentally-determined binding free energies differ remarkably. Thermodynamic cycles were constructed for the ligands, and simulations conducted in the bound and (freely solvated) unbound states. In the unbound state, it was observed that the difference in conformational freedom between alanine and glycine leads to a surprisingly slow convergence, despite their chemical similarity. This could be overcome by increasing the softness parameter during alchemical transformations. Discrepancies remained in the bound state however, when comparing independent simulations of the three ligands. These difficulties could be traced to a slow relaxation of the water network within the active site. Fluctuations in the number of water molecules residing in the binding cavity occur mostly on a timescale larger than the simulation time along the alchemical path. After extensive simulations, relative binding free energies that were converged to within thermal noise could be obtained, which agree well with available experimental data. PMID:27092480

Identification of membrane-associated proteins with pathogenic potential expressed by Corynebacterium pseudotuberculosis grown in animal serum.

PubMed

Raynal, José Tadeu; Bastos, Bruno Lopes; Vilas-Boas, Priscilla Carolinne Bagano; Sousa, Thiago de Jesus; Costa-Silva, Marcos; de Sá, Maria da Conceição Aquino; Portela, Ricardo Wagner; Moura-Costa, Lília Ferreira; Azevedo, Vasco; Meyer, Roberto

2018-01-25

Previous works defining antigens that might be used as vaccine targets against Corynebacterium pseudotuberculosis, which is the causative agent of sheep and goat caseous lymphadenitis, have focused on secreted proteins produced in a chemically defined culture media. Considering that such antigens might not reflect the repertoire of proteins expressed during infection conditions, this experiment aimed to investigate the membrane-associated proteins with pathogenic potential expressed by C. pseudotuberculosis grown directly in animal serum. Its membrane-associated proteins have been extracted using an organic solvent enrichment methodology, followed by LC-MS/MS and bioinformatics analysis for protein identification and classification. The results revealed 22 membrane-associated proteins characterized as potentially pathogenic. An interaction network analysis indicated that the four potentially pathogenic proteins ciuA, fagA, OppA4 and OppCD were biologically connected within two distinct network pathways, which were both associated with the ABC Transporters KEGG pathway. These results suggest that C. pseudotuberculosis pathogenesis might be associated with the transport and uptake of nutrients; other seven identified potentially pathogenic membrane proteins also suggest that pathogenesis might involve events of bacterial resistance and adhesion. The proteins herein reported potentially reflect part of the protein repertoire expressed during real infection conditions and might be tested as vaccine antigens.

Effects of prenatal marijuana on visuospatial working memory: an fMRI study in young adults.

PubMed

Smith, Andra M; Fried, Peter A; Hogan, Matthew J; Cameron, Ian

2006-01-01

The long lasting neurophysiological effects of prenatal marijuana exposure on visuospatial working memory were investigated in 18-22 year olds using functional magnetic resonance imaging (fMRI). The participants are members of the Ottawa Prenatal Prospective Study (OPPS), a longitudinal study that provides a unique body of information collected from each participant over 20 years, including prenatal drug history, detailed cognitive/behavioral performance from infancy to young adulthood, and current and past drug usage. This information allowed for the control of potentially confounding drug exposure variables in the statistical analyses. Thirty-one offspring from the OPPS (16 prenatally exposed and 15 nonexposed) performed a visuospatial 2-back task while neural activity was imaged with fMRI. Cognitive performance data were also collected. No significant performance differences were observed when comparing controls versus exposed participants. Multiple regression analyses (including controls with no exposure) revealed that as the amount of prenatal marijuana exposure increased, there was significantly more neural activity in the left inferior and middle frontal gyri, left parahippocampal gyrus, left middle occipital gyrus and left cerebellum. There was also significantly less activity in right inferior and middle frontal gyri. These results suggest that prenatal marijuana exposure alters neural functioning during visuospatial working memory processing in young adulthood.

Performance evaluation of different types of particle representation procedures of Particle Swarm Optimization in Job-shop Scheduling Problems

NASA Astrophysics Data System (ADS)

Izah Anuar, Nurul; Saptari, Adi

2016-02-01

This paper addresses the types of particle representation (encoding) procedures in a population-based stochastic optimization technique in solving scheduling problems known in the job-shop manufacturing environment. It intends to evaluate and compare the performance of different particle representation procedures in Particle Swarm Optimization (PSO) in the case of solving Job-shop Scheduling Problems (JSP). Particle representation procedures refer to the mapping between the particle position in PSO and the scheduling solution in JSP. It is an important step to be carried out so that each particle in PSO can represent a schedule in JSP. Three procedures such as Operation and Particle Position Sequence (OPPS), random keys representation and random-key encoding scheme are used in this study. These procedures have been tested on FT06 and FT10 benchmark problems available in the OR-Library, where the objective function is to minimize the makespan by the use of MATLAB software. Based on the experimental results, it is discovered that OPPS gives the best performance in solving both benchmark problems. The contribution of this paper is the fact that it demonstrates to the practitioners involved in complex scheduling problems that different particle representation procedures can have significant effects on the performance of PSO in solving JSP.

Effects of prenatal marijuana on response inhibition: an fMRI study of young adults.

PubMed

Smith, Andra M; Fried, Peter A; Hogan, Matthew J; Cameron, Ian

2004-01-01

The neurophysiological effects of prenatal marijuana exposure on response inhibition were assessed in 18- to 22-year-olds. Thirty-one participants from the Ottawa Prenatal Prospective Study (OPPS) performed a blocked design Go/No-Go task while neural activity was imaged with functional magnetic resonance imaging (fMRI). The OPPS is a longitudinal study that provides a unique body of information collected from each participant over 20 years, including prenatal drug history, detailed cognitive/behavioral performance from infancy to young adulthood, and current and past drug usage. The fMRI results showed that with increased prenatal marijuana exposure, there was a significant increase in neural activity in bilateral prefrontal cortex and right premotor cortex during response inhibition. There was also an attenuation of activity in left cerebellum with increased prenatal exposure to marijuana when challenging the response inhibition neural circuitry. Prenatally exposed offspring had significantly more commission errors than nonexposed participants, but all participants were able to perform the task with more than 85% accuracy. These findings were observed when controlling for present marijuana use and prenatal exposure to nicotine, alcohol and caffeine, and suggest that prenatal marijuana exposure is related to changes in neural activity during response inhibition that last into young adulthood. Copyright 2004 Elsevier Inc.

77 FR 24737 - Notice of Proposed Information Collection

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2012-04-25

... its maintenance of state programs and procedures for substituting Federal enforcement of state programs and withdrawing approval of state programs, has been forwarded to the Office of Management and...: Submit comments to the Office of Information and Regulatory Affairs, Office of Management and Budget...

32 CFR 2400.45 - Information Security Program Review.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.45...

32 CFR 2400.45 - Information Security Program Review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.45...

32 CFR 2400.45 - Information Security Program Review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.45...

32 CFR 2400.45 - Information Security Program Review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.45...

32 CFR 2400.45 - Information Security Program Review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.45...

The Path to a Cure for Hepatitis C in People With HIV

MedlinePlus

... of the Director Office of the Chief Science Management & Operations Administrative Services Office of Biodefense Research & Surety Communications ... Office of Clinical Research Policy and Regulatory Planning Operations Support Program Planning Analysis ... Office of Acquisitions Scientific Review Program Division ...

76 FR 40339 - Patent Prosecution Highway (PPH) Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... DEPARTMENT OF COMMERCE Patent and Trademark Office Patent Prosecution Highway (PPH) Program ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as... Information Officer, United States Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450...

32 CFR 2400.43 - Heads of offices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.43 Heads of...

32 CFR 2400.43 - Heads of offices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.43 Heads of...

32 CFR 2400.43 - Heads of offices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.43 Heads of...

32 CFR 2400.43 - Heads of offices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.43 Heads of...

32 CFR 2400.43 - Heads of offices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.43 Heads of...

INTEGRATED COASTAL MONITORING PROGRAM FOR THE GULF OF MEXICO

EPA Science Inventory

The Gulf of Mexico Program (GMP) Office in cooperation with Gulf State agencies, EPA Regions 4 and 6, EPA's Office of Water and Office of Research and Development (ORD), and the GMP principal partners are developing an integrated coastal monitoring program for the Gulf of Mexico....

49 CFR 1.34 - Delegations to the Assistant Secretary for Budget and Programs and Chief Financial Officer.

Code of Federal Regulations, 2012 CFR

2012-10-01

... (ESC) regarding all financial management activities conducted by ESC and financial systems operated by... day-to-day operating management responsibility over the Office of Budget and Program Performance, the Office of Financial Management, and the Office of the CFO for the Office of the Secretary. (c) Direct and...

49 CFR 1.34 - Delegations to the Assistant Secretary for Budget and Programs and Chief Financial Officer.

Code of Federal Regulations, 2013 CFR

2013-10-01

... (ESC) regarding all financial management activities conducted by ESC and financial systems operated by... day-to-day operating management responsibility over the Office of Budget and Program Performance, the Office of Financial Management, and the Office of the CFO for the Office of the Secretary. (c) Direct and...

49 CFR 1.34 - Delegations to the Assistant Secretary for Budget and Programs and Chief Financial Officer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... (ESC) regarding all financial management activities conducted by ESC and financial systems operated by... day-to-day operating management responsibility over the Office of Budget and Program Performance, the Office of Financial Management, and the Office of the CFO for the Office of the Secretary. (c) Direct and...

A Model for a Single Unmanned Aircraft Systems (UAS) Program Office Managing Joint ISR Capabilities

DTIC Science & Technology

2017-10-01

reduction in manning from the multiple program office structure to the new single program management model. Additional information regarding this...OFFICE MANAGING JOINT ISR CAPABILITIES by Angela E. Burris A Research Report Submitted to the Faculty In Partial Fulfillment of...research paper is to answer how a single management office could provide greater agility for unmanned aircraft systems (UAS); supporting Joint concepts

77 FR 62533 - Agency Information Collection Activities; Proposed Collection, Comments Requested; Revision of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... DEPARTMENT OF JUSTICE Federal Bureau of Investigation [OMB Number 1110-0009] Agency Information...: Law Enforcement Officers Killed and Assaulted Program; Analysis of Officer Feloniously Killed and Assaulted Law Enforcement Officers Killed and Assaulted Program; Analysis of Officers Accidentally Killed...

77 FR 74877 - Agency Information Collection Activities; Proposed Collection, Comments Requested; Revision of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-18

... DEPARTMENT OF JUSTICE Federal Bureau of Investigation [OMB Number 1110-0009] Agency Information...; Law Enforcement Officers Killed and Assaulted Program, Analysis of Officers; Feloniously Killed and Assaulted; and Law Enforcement Officers Killed and Assaulted Program, Analysis of Officers Accidentally...

The Saturn management concept

NASA Technical Reports Server (NTRS)

Bilstein, R. E.

1974-01-01

Management of the Saturn launch vehicles was an evolutionary process, requiring constant interaction between NASA Headquarters, the Marshall Space Flight Center (particularly the Saturn 5 Program Office), and the various prime contractors. Successful Saturn management was a blend of the decades of experience of the von Braun team, management concepts from the Army, Navy, Air Force, and Government, and private industry. The Saturn 5 Program Office shared a unique relationship with the Apollo Program Office at NASA Headquarters. Much of the success of the Saturn 5 Program Office was based on its painstaking attention to detail, emphasis on individual responsibilities (backed up by comprehensive program element plans and management matrices), and a high degree of visibility as embodied in the Program Control Center.

Do adolescents perceive police officers as credible instructors of substance abuse prevention programs?

PubMed

Hammond, Augustine; Sloboda, Zili; Tonkin, Peggy; Stephens, Richard; Teasdale, Brent; Grey, Scott F; Williams, Joseph

2008-08-01

Although program recipients' attitudes toward instructors are crucial to program outcomes, they have not been adequately examined in the substance abuse prevention literature. This study uses survey data to explore attitudes toward instructors of prevention programming held by students from a national longitudinal evaluation of a school-based substance abuse prevention program delivered by Drug Abuse Resistance Education (D.A.R.E.) officers. Our analyses indicated that students who had police officers as instructors evaluated program instructors significantly higher than students who had non-police officers as instructors. The evaluation of police instructors varied according to students' sociodemographic characteristics. Implications for future research and practice are considered.

75 FR 27000 - Hearings of the Review Panel on Prison Rape

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OJP) Docket No. 1519] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

76 FR 20711 - Hearings of the Review Panel on Prison Rape

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OCR) Docket No. 1548] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

78 FR 77495 - Hearings of the Review Panel on Prison Rape

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-23

... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (OCR) Docket No. 1642] Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs, Justice. ACTION: Notice of Hearing. SUMMARY: The Office of Justice Programs (OJP) announces that the Review Panel on Prison Rape (Panel) will...

77 FR 16250 - Notice of Proposed Information Collection for Public Comment; Office of Native American Programs...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-20

... Information Collection for Public Comment; Office of Native American Programs (ONAP) Training and Technical... subject proposal. The data required by Office of Native American Programs Training and Technical... progress. The data identifies needs, outputs and outcomes of the training and technical assistance. DATES...

75 FR 32972 - Federal Employees Health Benefits Program; Medically Underserved Areas for 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

... OFFICE OF PERSONNEL MANAGEMENT Federal Employees Health Benefits Program; Medically Underserved Areas for 2011 AGENCY: Office of Personnel Management. ACTION: Notice. SUMMARY: The U.S. Office of... Underserved Areas under the Federal Employees Health Benefits (FEHB) Program for calendar year 2011. This is...

76 FR 31998 - Federal Employees Health Benefits Program: Medically Underserved Areas for 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

... OFFICE OF PERSONNEL MANAGEMENT Federal Employees Health Benefits Program: Medically Underserved Areas for 2012 AGENCY: U.S. Office of Personnel Management. ACTION: Notice. SUMMARY: The U.S. Office of... Underserved Areas under the Federal Employees Health Benefits (FEHB) Program for calendar year 2012. This is...

20 CFR 410.705 - Duplicate claims.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Administration—denied or pending with the Office of Workers' Compensation Programs. A person whose part B claim... the Office of Workers' Compensation Programs which is pending or has been denied shall be entitled to a review of the part C claim by the Office of Workers' Compensation Programs under the BLBRA of 1977...

76 FR 28459 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Revisions of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... Administrator, Office of Juvenile Justice and Delinquency Prevention, Office of Justice Programs, Department of... and Delinquency Prevention, Office of Justice Programs, Department of Justice. (4) Affected public who... (TTAC) and the Office for Juvenile Justice and Delinquency Prevention National Training and Technical...