Investigation of DMSD Trend in the ISS Water Processor Assembly

NASA Technical Reports Server (NTRS)

Carter, Layne; Bowman, Elizabeth; Wilson, Mark; Gentry, Greg; Rector, Tony

2013-01-01

The ISS Water Recovery System (WRS) is responsible for providing potable water to the crew, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. The WRS includes the Water Processor Assembly (WPA) and the Urine Processor Assembly (UPA). The WPA processes condensate from the cabin air and distillate produced by the UPA. In 2010, an increasing trend in the Total Organic Carbon (TOC) in the potable water was ultimately identified as dimethylsilanediol (DMSD). The increasing trend was ultimately reversed after replacing the WPA's two multifiltration beds. However, the reason for the TOC trend and the subsequent recovery was not understood. A subsequent trend occurred in 2012. This paper summarizes the current understanding of the fate of DMSD in the WPA, how the increasing TOC trend occurred, and the plan for modifying the WPA to prevent recurrence.

78 FR 24435 - Notice of Availability of the Proposed Notice of Sale (NOS) for Western Gulf of Mexico Planning...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... of the Proposed Notice of Sale (NOS) for Western Gulf of Mexico Planning Area (WPA) Outer Continental Shelf (OCS) Oil and Gas Lease Sale 233 (WPA Sale 233) AGENCY: Bureau of Ocean Energy Management (BOEM), Interior. ACTION: Notice of Availability of the Proposed Notice of WPA Sale 233 SUMMARY: BOEM announces the...

Performance Qualification Test of the ISS Water Processor Assembly (WPA) Expendables

NASA Technical Reports Server (NTRS)

Carter, Layne; Tabb, David; Tatara, James D.; Mason, Richard K.

2005-01-01

The Water Processor Assembly (WPA) for use on the International Space Station (ISS) includes various technologies for the treatment of waste water. These technologies include filtration, ion exchange, adsorption, catalytic oxidation, and iodination. The WPA hardware implementing portions of these technologies, including the Particulate Filter, Multifiltration Bed, Ion Exchange Bed, and Microbial Check Valve, was recently qualified for chemical performance at the Marshall Space Flight Center. Waste water representing the quality of that produced on the ISS was generated by test subjects and processed by the WPA. Water quality analysis and instrumentation data was acquired throughout the test to monitor hardware performance. This paper documents operation of the test and the assessment of the hardware performance.

Psychosomatic symptoms among Palestinian nurses exposed to workplace aggression.

PubMed

Jaradat, Yousef; Nielsen, Morten Birkeland; Bast-Pettersen, Rita

2018-06-01

The study examined associations between workplace aggression (WPA) and psychosomatic symptoms in Palestinian nurses. The 341 nurses, (62% females and 38% males), answered a WHO questionnaire and a psychosomatic symptoms checklist. A total of 27.3% of the nurses reported exposure to WPA of any kind within the last 12 months. After adjusting for covariates, female nurses exposed to WPA of any kind and those exposed to verbal aggression reported a higher symptom score: (1.5; 95% confidence interval [CI]: 0.3, 2.7), and (1.4; 95%CI 0.2, 2.6), respectively, than unexposed females. Male nurses exposed to bullying reported a higher symptom score: (3.2; 95%CI 1.0, 5.5) than unexposed males. Exposure to WPA was associated with higher occurrences of psychosomatic symptoms for both sexes. The female nurses reacted most strongly to verbal aggression or to WPA of any type, while bullying was associated with the male nurses' symptoms. © 2018 Wiley Periodicals, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Wind Powering America FY06 Activities Summary reflects the accomplishments of our state wind working groups, our programs at the National Renewable Energy Laboratory, and our partner organizations. The national WPA team remains a leading force for moving wind energy forward in the United States. WPA continues to work with its national, regional, and state partners to communicate the opportunities and benefits of wind energy to a diverse set of stakeholders. WPA now has 29 state wind working groups (welcoming New Jersey, Indiana, Illinois, and Missouri in 2006) that form strategic alliances to communicate wind's benefits to the state stakeholders.more » More than 120 members of national and state public and private sector organizations from 34 states attended the 5th Annual WPA All-States Summit in Pittsburgh in June.« less

Launching Curricular Reform in First-Year Composition: Navigating the Terrain between Buy-in and Burnout

ERIC Educational Resources Information Center

Deacon, Andrea

2013-01-01

One of the most taxing duties of a writing program administrator (WPA), and one that is likely to cause the most burnout, is initiating curricular reform, an initiative often met with pushback and resistance. Within the literature on curriculum reform in first-year composition, this resistance seems to arise from a complex web of issues related to…

Design and Delivery of a Filter for Removal of Siloxanes from the ISS Atmosphere

NASA Technical Reports Server (NTRS)

Carter, Layne; Kayatin, Matthew; Perry, Jay; Agui, Juan; Green, Robert; Gentry, Gregory; Bowman, Elizabeth; Wilson, Mark; Rector, Tony

2016-01-01

Dimethylsilanediol (DMSD) has been identified as a problematic chemical contaminant aboard ISS. This contaminant was initially identified in the ISS condensate and in the Water Processor Assembly (WPA) product water in 2010 when an increasing total organic carbon (TOC) trend was detected in the water produced by the WPA. DMSD is not a crew health hazard at the levels observed in the product water, but it may degrade the performance of the Oxygen Generation System (OGS) which uses product produced by the WPA for electrolysis. In addition, DMSD can prevent the effective operation of the WPA catalytic reactor, and necessitates early replacement of Multifiltration Beds in the WPA. An investigation into the source of DMSD has determined that polydimethylsiloxanes (PDMSs) are hydrolyzing in the Condensing Heat Exchanger (CHX) to form DMSD. PDMSs are prevalent aboard ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallics. TPDMSs are also implicated in CHX hydrophilic coating degradation, rendering it hydrophobic and adversely affecting its ability to effectively transmit water to the condensate bus. Eventually this loss in performance results in water droplets in the air flow out of the CHX core, which can lead to microbial growth in the air ducts and can impact the performance of downstream systems. Design concepts have now been developed for removing PDMS in the air stream before it can reach the CHX core, thus preventing degradation of the coating and decomposition of the PDMS to DMSD. This paper summarizes the current status of the effort to deliver filters to ISS for removing PDMSs from the atmosphere before they can adversely impact the performance of the CHX coating and the WPA.

77 FR 68147 - Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas Lease...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Environmental Impact Statement (Multisale FEIS). Authority: This NOA is published pursuant to the regulations... NEPA process. The Multisale FEIS evaluated the environmental and socioeconomic impacts for WPA Lease... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico, Outer Continental...

76 FR 50245 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-12

... (BOEMRE), Interior. ACTION: Notice of Availability (NOA) of a Final Supplemental Environmental Impact... sale's incremental contribution to the cumulative impacts on environmental and socioeconomic resources... Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas Lease Sale for the...

Impact of a physical activity program on the anxiety, depression, occupational stress and burnout syndrome of nursing professionals.

PubMed

Freitas, Anderson Rodrigues; Carneseca, Estela Cristina; Paiva, Carlos Eduardo; Paiva, Bianca Sakamoto Ribeiro

2014-01-01

to assess the effects of a workplace physical activity (WPA) program on levels of anxiety, depression, burnout, occupational stress and self-perception of health and work-related quality of life of a nursing team in a palliative care unit. the WPA was conducted five days per week, lasting ten minutes, during three consecutive months. Twenty-one nursing professionals were evaluated before and after the intervention, with the Hospital Anxiety and Depression Scale, the Maslch Burnout Inventory, and the Job Stress Scale. The changes in self-perceived health and work-related quality of life were measured using a semi-structured questionnaire. the WPA did not yield significant results on the levels of anxiety, depression, burnout or occupational stress. However, after the intervention, participants reported improved perceptions of bodily pain and feeling of fatigue at work. the WPA did not lead to beneficial effects on occupational stress and psychological variables, but it was well accepted by the nursing professionals, who reported improvement in perceptions of health and work-related quality of life.

Insecurity of Wireless Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheldon, Frederick T; Weber, John Mark; Yoo, Seong-Moo

Wireless is a powerful core technology enabling our global digital infrastructure. Wi-Fi networks are susceptible to attacks on Wired Equivalency Privacy, Wi-Fi Protected Access (WPA), and WPA2. These attack signatures can be profiled into a system that defends against such attacks on the basis of their inherent characteristics. Wi-Fi is the standard protocol for wireless networks used extensively in US critical infrastructures. Since the Wired Equivalency Privacy (WEP) security protocol was broken, the Wi-Fi Protected Access (WPA) protocol has been considered the secure alternative compatible with hardware developed for WEP. However, in November 2008, researchers developed an attack on WPA,more » allowing forgery of Address Resolution Protocol (ARP) packets. Subsequent enhancements have enabled ARP poisoning, cryptosystem denial of service, and man-in-the-middle attacks. Open source systems and methods (OSSM) have long been used to secure networks against such attacks. This article reviews OSSMs and the results of experimental attacks on WPA. These experiments re-created current attacks in a laboratory setting, recording both wired and wireless traffic. The article discusses methods of intrusion detection and prevention in the context of cyber physical protection of critical Internet infrastructure. The basis for this research is a specialized (and undoubtedly incomplete) taxonomy of Wi-Fi attacks and their adaptations to existing countermeasures and protocol revisions. Ultimately, this article aims to provide a clearer picture of how and why wireless protection protocols and encryption must achieve a more scientific basis for detecting and preventing such attacks.« less

Upgrades to the ISS Water Recovery System

NASA Technical Reports Server (NTRS)

Kayatin, Matthew J.; Carter, Donald L.; Schunk, Richard G.; Pruitt, Jennifer M.

2016-01-01

The International Space Station Water Recovery System (WRS) is comprised of the Water Processor Assembly (WPA) and the Urine Processor Assembly (UPA). The WRS produces potable water from a combination of crew urine (first processed through the UPA), crew latent, and Sabatier product water. Though the WRS has performed well since operations began in November 2008, several modifications have been identified to improve the overall system performance. These modifications can reduce resupply and improve overall system reliability, which is beneficial for the ongoing ISS mission as well as for future NASA manned missions. The following paper details efforts to reduce the resupply mass of the WPA Multifiltration Bed, develop improved catalyst for the WPA Catalytic Reactor, evaluate optimum operation of UPA through parametric testing, and improve reliability of the UPA fluids pump and Distillation Assembly.

Recovery of Uranium from Wet Phosphoric Acid by Solvent Extraction Processes

DOE PAGES

Beltrami, Denis; Cote, Gérard; Mokhtari, Hamid; ...

2014-11-17

Between 1951 and 1991, we developed about 17 processes to recover uranium from wet phosphoric acid (WPA), but the viability of these processes was subject to the variation of the uranium price market. Nowadays, uranium from WPA appears to be attractive due to the increase of the global uranium demand resulting from the emergence of developing countries. Moreover, the increasing demand provides impetus for a new look at the applicable technology with a view to improvements as well as altogether new approaches. This paper gives an overview on extraction processes developed in the past to recover uranium from wet phosphoricmore » acid (WPA) as well as the physicochemistry involved in these processes. Recent advances concerning the development of new extraction systems are also reported and discussed.« less

Tier One Performance Screen Initial Operational Test and Evaluation: 2012 Annual Report

DTIC Science & Technology

2014-05-01

Personality Assessment System ([TAPAS]; Stark, Chernyshenko, & Drasgow, 2010) surfaced as the top choice, with the Work Preferences Assessment ([WPA...indicator of personal motivation. The WPA asks applicants to indicate their preference for various kinds of work activities and environments (e.g...feature of the TAPAS is that pools of statements representing more than 20 narrow personality traits are available. The initial TAPAS trait taxonomy was

17. Photocopy of original plan, September 1936. W.P.A. NEW JERSEY/ ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of original plan, September 1936. W.P.A. NEW JERSEY/ DIVISION WOMEN'S & PROFESSIONAL PROJECTS/ELIZABETH C. D. VANN, DIRECTOR/RIPARIAN & STREAM SURVEY OP. 165-22-6999/PROJECT 10-197: PLAN OF DUNDEE DAM SHOWING STRUCTURES-SECTIONS AND ELEVATIONS (On file at Hackensack Water Company) - Dundee Canal, Headgates, Guardlock & Uppermost Section, 250 feet northeast of Randolph Avenue, opposite & in line with East Clifton Avenue, Clifton, Passaic County, NJ

Industrial wastewater minimization using water pinch analysis: a case study on an old textile plant.

PubMed

Ujang, Z; Wong, C L; Manan, Z A

2002-01-01

Industrial wastewater minimization can be conducted using four main strategies: (i) reuse; (ii) regeneration-reuse; (iii) regeneration-recycling; and (iv) process changes. This study is concerned with (i) and (ii) to investigate the most suitable approach to wastewater minimization for an old textile industry plant. A systematic water networks design using water pinch analysis (WPA) was developed to minimize the water usage and wastewater generation for the textile plant. COD was chosen as the main parameter. An integrated design method has been applied, which brings the engineering insight using WPA that can determine the minimum flowrate of the water usage and then minimize the water consumption and wastewater generation as well. The overall result of this study shows that WPA has been effectively applied using both reuse and regeneration-reuse strategies for the old textile industry plant, and reduced the operating cost by 16% and 50% respectively.

Community mental health care in the Asia-Pacific region: using current best-practice models to inform future policy

PubMed Central

NG, CHEE; HERRMAN, HELEN; CHIU, EDMOND; SINGH, BRUCE

2009-01-01

The reporting of child sexual abuse (CSA) and physician-patient sexual relationships (PPSR) are currently the focus of professional, legal and media attention in several countries. This paper briefly reviews mental health policies on these issues and reports on a WPA survey of them. While the WPA Madrid Declaration permits breaching confidentiality for mandatory reporting of CSA and clearly prohibits PPSR, it is not known how or to what extent these policies are implemented in WPA Member Societies’ countries. It is also not known whether policies or laws exist on these topics nationally or to what extent psychiatrists and the public are aware of them. Representatives of WPA Member Societies were e-mailed a survey about issues pertaining to CSA and PPSR. Fifty-one percent of 109 countries replied. All reporting countries had laws or policies regarding the reporting of CSA, but this was often voluntary (63%) and without protection for reporting psychiatrists either by law (29%) or by Member Societies (27%). A substantial number of psychiatric leaders did not know the law (27%) or their Society’s policy (11%) on these matters. With respect to PPSR, some reporting countries lacked laws or policies about PPSR with current (17%) or past (56%) patients. Fewer than half of responding representatives believed that their Society’s members or the public were well informed about the laws and policies pertaining to CSA or PPSR. There is clearly a wide range of laws, policies and practices about CSA and PPSR in WPA Member Societies’ countries. There is a need in some countries for laws or supplemental policies to facilitate the protection of vulnerable child and adult patients through clear, mandatory reporting policies for CSA and PPSR. Mechanisms to protect and support reporting psychiatrists should also be developed where they do not already exist. There is also a need in some countries to develop strategies to improve the education of psychiatrists, trainees, and the public on these issues. PMID:19293961

International Space Station (ISS)

NASA Image and Video Library

2001-02-01

The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the fifth generation Urine Processor Development Hardware. The Urine Processor Assembly (UPA) is a part of the Water Recovery System (WRS) on the ISS. It uses a chase change process called vapor compression distillation technology to remove contaminants from urine. The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the Water Processor Assembly (WPA). The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. Product water quality is monitored primarily through conductivity measurements. Unacceptable water is sent back through the WPA for reprocessing. Clean water is sent to a storage tank.

Environmental Control and Life Support Systems Testing Facility at MSFC

NASA Technical Reports Server (NTRS)

2001-01-01

The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the Urine Processor Assembly (UPA) which utilizes the Vapor Compression Distillation (VCD) technology. The VCD is used for integrated testing of the entire Water Recovery System (WRS) and development testing of the Urine Processor Assembly. The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the Water Processor Assembly (WPA). The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. Product water quality is monitored primarily through conductivity measurements. Unacceptable water is sent back through the WPA for reprocessing. Clean water is sent to a storage tank.

World Psychiatry and the WPA task force to promote dissemination of psychiatric research conducted in low and middle income countries.

PubMed

Maj, Mario

2010-01-01

World Psychiatry, the official journal of the World Psychiatric Association (WPA), is now published in five languages (English, Spanish, Chinese, Russian and French) and reaches more than 33,000 psychiatrists in 121 countries. It received recently its first impact factor, 3.896. The publication of the journal has two objectives. The first is to reach as many psychiatrists of the various countries of the world as possible, disseminating information on recent significant clinical, service and research developments in a language that can be assimilated by the vast majority of them. The second is to give voice to psychiatrists of all regions of the world, encouraging submission of research papers, commentaries and reports on innovative service modalities. Related to this second objective has been the establishment by the WPA of a task force aiming to promote dissemination of psychiatric research conducted in low and middle income countries. Among the objectives of this task force is to advise and support the editors of high quality journals produced in those countries in their efforts to achieve indexation.

Design Solutions for the Treatment of DMSD in the ISS Water Recovery System

NASA Technical Reports Server (NTRS)

Perry, Jay; Carter, Donald; Kayatin, Matthew; Bowman, Elizabeth; Gentry, Greg; Muirhead, Brian; Gazda, Daniel; Wilson, Mark

2017-01-01

Dimethylsilanediol (DMSD) has been identified as a problematic organic on ISS. This contaminant was initially identified in the Water Processor Assembly (WPA) product water in 2010 by the Total Organic Carbon Analyzer (TOCA). DMSD is not a crew health hazard at the levels observed in the product water, but it may degrade the performance of the Oxygen Generation System (OGS) which uses the WPA product water for electrolysis and does impact the effective operation of the WPA catalytic reactor. To mitigate these impacts, early replacement of the Multifiltration Beds in the WPA is required. An investigation has determined that the decomposition of atmospheric polydimethylsiloxanes (PDMSs) is the primary source of DMSD in the condensate. PDMSs are prevalent on ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallics. These PDMSs also contribute to degradation of the CHX hydrophilic coating, rendering it hydrophobic and therefore affecting its ability to transmit water to the condensate bus. In addition, literature research has determined that PDMSs are likely oxidized to DMSD in the atmosphere when exposed to hydroxyl radicals in the ISS atmosphere. To address these mechanisms, filters have been developed for removal of PDMSs from the ISS atmosphere. However, ongoing analysis indicates a significant reduction in atmospheric PDMSs is required to achieve a measurable reduction of DMSD in the condensate. As a result, additional measures are being pursued to mitigate this issue. First, credible sources are being investigated to quantity to the extent possible the significant sources of PDMSs and identify sources that can be reasonably removed from ISS. Second, a Reverse Osmosis technology is being investigated as an alternate means for removing DMSD from the condensate. This paper summarizes the current status of the overall effort to mitigate DMSD in the US condensate.

Process Development for Removal of Siloxanes from ISS Atmosphere

NASA Technical Reports Server (NTRS)

Carter, Layne; Perry, Jay; Kayatin, Matthew J.; Wilson, Mark; Gentry, Gregory J.; Bowman, Elizabeth; Monje, Oscar; Rector, Tony; Steele, John

2015-01-01

Dimethylsilanediol (DMSD) has been identified as a problematic organic contaminant aboard the ISS. This contaminant was initially identified in humidity condensate and in the Water Processor Assembly (WPA) product water in 2010 when routine water quality monitoring an increasing total organic carbon (TOC) trend in the WPA product water. Although DMSD is not a crew health hazard at the levels observed in the product water, it can degrade the WPA catalytic reactor's effectiveness and cause early replacement of Multifiltration Beds. DMSD may also degrade the performance of the Oxygen Generation System (OGS) which uses the WPA product water for electrolysis. An investigation into the source of DMSD has determined that polydimethylsiloxane (PDMS) compounds are likely hydrolyzing in the Condensing Heat Exchangers (CHX) to form DMSD. PDMS compounds are prevalent aboard ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallic materials. PDMS compounds are also known to contribute to CHX hydrophilic coating degradation by rendering it hydrophobic and therefore adversely affecting its ability to effectively transmit water to the condensate bus. Eventually this loss in performance results in water droplets in the air flow exiting the CHX, which may lead to microbial growth in the air ducts and may impact the performance of downstream systems. Several options have been evaluated to address these concerns. Modifications to the Water Processor Multifiltration Beds and Catalytic Reactor for removal of DMSD were not considered viable, and did not address the issue with PDMS compound degradation of the CHX coating. Design concepts are now in development for removing PDMS compounds from the air stream before they can reach the CHX coating, thus preventing coating degradation and hydrolysis of the PDMS compounds to DMSD. This paper summarizes the current status of the effort to treat these contaminants on ISS.

Environmental Control and Life Support Systems Testing Facility at MSFC

NASA Technical Reports Server (NTRS)

2001-01-01

The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the fifth generation Urine Processor Development Hardware. The Urine Processor Assembly (UPA) is a part of the Water Recovery System (WRS) on the ISS. It uses a chase change process called vapor compression distillation technology to remove contaminants from urine. The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the Water Processor Assembly (WPA). The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. Product water quality is monitored primarily through conductivity measurements. Unacceptable water is sent back through the WPA for reprocessing. Clean water is sent to a storage tank.

Development of Advanced ISS-WPA Catalysts for Organic Oxidation at Reduced Pressure/Temperature

NASA Technical Reports Server (NTRS)

Yu, Ping; Nalette, Tim; Kayatin, Matthew

2016-01-01

The Water Processor Assembly (WPA) at International Space Station (ISS) processes a waste stream via multi-filtration beds, where inorganic and non-volatile organic contaminants are removed, and a catalytic reactor, where low molecular weight organics not removed by the adsorption process are oxidized at elevated pressure in the presence of oxygen and elevated temperature above the normal water boiling point. Operation at an elevated pressure requires a more complex system design compared to a reactor that could operate at ambient pressure. However, catalysts currently available have insufficient activity to achieve complete oxidation of the organic load at a temperature less than the water boiling point and ambient pressure. Therefore, it is highly desirable to develop a more active and efficient catalyst at ambient pressure and a moderate temperature that is less than water boiling temperature. This paper describes our efforts in developing high efficiency water processing catalysts. Different catalyst support structures and coating metals were investigated in subscale reactors and results were compared against the flight WPA catalyst. Detailed improvements achieved on alternate metal catalysts at ambient pressure and 200 F will also be presented in the paper.

Multilfiltration Bed Replacement (MFBR) System for the International Space Station using Aquaporin Membranes and Humidity Condensate Ersatz Wastewater

NASA Technical Reports Server (NTRS)

Shaw, Hali L.; Howard, Kevin; Flynn, Michael T.; Beeler, David; Kawashima, Brian; Andersen, Thomas A. E.; Kleinschmidt, Kim; Vogel, Jorg; Parodi, Jurek

2017-01-01

The Multifiltration Bed system in the International Space Station (ISS) Water Processor Assembly (WPA) needs to be improved by reducing or eliminating the usage rate of expendable media, removing dimethylsilanediol (DMSD), and reducing the overall system mass. The WPA contains two multifiltration beds, each with a mass of approximately 50 kg. Reducing the mass of the WPA is an important part of evolving the ISS system for future exploration missions. The Multifiltration Bed Replacement (MFBR) technology is based on biomimetic membranes, which derive their unique characteristics from aquaporins, or water channel proteins. Aquaporin membranes were commercialized by the company Aquaporin AS. Tests were conducted using the Aquaporin Inside Hollow Fiber Module to determine the maximum water recovery ratio and membrane life. Samples were analyzed for total organic carbon (TOC), DMSD, acetate, ions, and volatiles such as ethanol and acetone. The results indicate that at a 97.498.1 water recovery ratio, the membrane module can reject approximately 50 of the TOC and specific conductance using the simulated ISS MSFC humidity condensate ersatz. Additionally, the life of the membrane was determined to be a minimum of 7103 hours.

Analyzers Provide Water Security in Space and on Earth

NASA Technical Reports Server (NTRS)

2012-01-01

Resourcefulness is a key quality for living in space, and on the International Space Station (ISS), that means making the most of water supplies. In 2008, the installation of the Water Processing Assembly (WPA) onboard the ISS allowed the space station s crew to do just that. The WPA purifies moisture from nearly every possible source - sweat, water vapor, wastewater, and even urine - for drinking and oxygen generation. Capable of producing 35 gallons of potable, recycled water a day, the system has reduced the need for water delivered to the ISS by over 1,000 gallons a year, saving significant payload costs in the process. As with any drinking water, quality is a concern, particularly when that water has been recycled. This is an issue of particular interest in space, where ISS crewmembers would have to deal with any illness far from the nearest medical personnel and facilities. The WPA employs sensors that monitor water quality by measuring its conductivity, and rounding out the system s quality assurance methods is a device developed for NASA by a private industry partner. That company has now made the technology available for ensuring the purity of water for consumption and industrial uses on Earth.

Partnerships for better mental health worldwide: WPA recommendations on best practices in working with service users and family carers

PubMed Central

WALLCRAFT, JAN; AMERING, MICHAELA; FREIDIN, JULIAN; DAVAR, BHARGAVI; FROGGATT, DIANE; JAFRI, HUSSAIN; JAVED, AFZAL; KATONTOKA, SYLVESTER; RAJA, SHOBA; RATAEMANE, SOLOMON; STEFFEN, SIGRID; TYANO, SAM; UNDERHILL, CHRISTPHER; WAHLBERG, HENRIK; WARNER, RICHARD; HERRMAN, HELEN

2011-01-01

WPA President M. Maj established the Task Force on Best Practice in Working with Service Users and Carers in 2008, chaired by H. Herrman. The Task Force had the remit to create recommendations for the international mental health community on how to develop successful partnership working. The work began with a review of literature on service user and carer involvement and partnership. This set out a range of considerations for good practice, including choice of appropriate terminology, clarifying the partnership process and identifying and reducing barriers to partnership working. Based on the literature review and on the shared knowledge in the Task Force, a set of ten recommendations for good practice was developed. These recommendations were the basis for a worldwide consultation of stakeholders with expertise as service users, families and carers, and the WPA Board and Council. The results showed a strong consensus across the international mental health community on the ten recommendations, with the strongest agreement coming from service users and carers. This general consensus gives a basis for Task Force plans to seek support for activities to promote shared work worldwide to identify best practice examples and create a resource to assist others to begin successful collaboration. PMID:21991284

International Space Station (ISS)

NASA Image and Video Library

2001-03-01

The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

Personality disorder: a new global perspective

PubMed Central

TYRER, PETER; MULDER, ROGER; CRAWFORD, MIKE; NEWTON-HOWES, GILES; SIMONSEN, ERIK; NDETEI, DAVID; KOLDOBSKY, NESTOR; FOSSATI, ANDREA; MBATIA, JOSEPH; BARRETT, BARBARA

2010-01-01

Personality disorder is now being accepted as an important condition in mainstream psychiatry across the world. Although it often remains unrecognized in ordinary practice, research studies have shown it is common, creates considerable morbidity, is associated with high costs to services and to society, and interferes, usually negatively, with progress in the treatment of other mental disorders. We now have evidence that personality disorder, as currently classified, affects around 6% of the world population, and the differences between countries show no consistent variation. We are also getting increasing evidence that some treatments, mainly psychological, are of value in this group of disorders. What is now needed is a new classification that is of greater value to clinicians, and the WPA Section on Personality Disorders is currently undertaking this task. PMID:20148162

Whistleblower Protection

EPA Pesticide Factsheets

The Whistleblower Protection Enhancement Act of 2012 (WPA) and the Whistleblower Protection Act of 1989 Enhanced by the Act of 2012 provides protection rights for Federal employees against retaliation for whistleblowing activities.

Environmental Control and Life Support System Mockup

NASA Technical Reports Server (NTRS)

2001-01-01

The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

Status of the International Space Station Regenerative ECLSS Water Recovery and Oxygen Generation Systems

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Cloud, Dale

2005-01-01

NASA is developing three racks containing regenerative water recovery and oxygen generation systems (WRS and OGS) for deployment on the International Space Station (ISS). The major assemblies included in these racks are the Water Processor Assembly (WPA), Urine Processor Assembly (UPA), Oxygen Generation Assembly (OGA), and the Power Supply Module (PSM) supporting the OGA. The WPA and OGA are provided by Hamilton Sundstrand Space Systems International (HSSSI), Inc., while the UPA and PSM are developed in- house by the Marshall Space Flight Center (MSFC). The assemblies have completed the manufacturing phase and are in various stages of testing and integration into the flight racks. This paper summarizes the status as of April 2005 and describes some of the technical challenges encountered and lessons learned over the past year.

Col WPA2 Degassing

NASA Image and Video Library

2009-07-09

ISS020-E-018137 (9 July 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, works with the Fluid Servicing System (FSS) in the Columbus laboratory of the International Space Station.

Col WPA2 Degassing

NASA Image and Video Library

2009-07-09

ISS020-E-018135 (9 July 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, works with the Fluid Servicing System (FSS) in the Columbus laboratory of the International Space Station.

Status of the Node 3 Regenerative Environmental Cpntrol& Life Support System Water Recovery & Oxygen Generation Systems

NASA Technical Reports Server (NTRS)

Carrasquillo, Robyn L.

2003-01-01

NASA s Marshall Space Flight Center is providing three racks containing regenerative water recovery and oxygen generation systems (WRS and OGS) for flight on the lnternational Space Station s (ISS) Node 3 element. The major assemblies included in these racks are the Water Processor Assembly (WPA), Urine Processor Assembly (UPA), Oxygen Generation Assembly (OGA), and the Power Supply Module (PSM) supporting the OGA. The WPA and OGA are provided by Hamilton Sundstrand Space Systems lnternational (HSSSI), while the UPA and PSM are being designed and manufactured in-house by MSFC. The assemblies are currently in the manufacturing and test phase and are to be completed and integrated into flight racks this year. This paper gives an overview of the technologies and system designs, technical challenges encountered and solved, and the current status.

Environmental Control and Life Support System, Water Recovery System

NASA Technical Reports Server (NTRS)

2000-01-01

The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This is a close-up view of ECLSS Water Recovery System (WRS) racks. The MSFC's ECLSS Group overseas much of the development of the hardware that will allow a constant supply of clean water for four to six crewmembers aboard the ISS. The WRS provides clean water through the reclamation of wastewaters, including water obtained from the Space Shuttle's fuel cells, crewmember urine, used shower, handwash and oral hygiene water cabin humidity condensate, and Extravehicular Activity (EVA) wastes. The WRS is comprised of a Urine Processor Assembly (UPA), and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA, which removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. Product water quality is monitored primarily through conductivity measurements. Unacceptable water is sent back through the WPA for reprocessing. Clean water is sent to a storage tank. The water must meet stringent purity standards before consumption by the crew. The UPA provided by the MSFC and the WRA is provided by the prime contractor, Hamilton Sundstrand Space Systems, International (HSSSI) from Cornecticut.

Improved Dynamic Modeling of the Cascade Distillation Subsystem and Integration with Models of Other Water Recovery Subsystems

NASA Technical Reports Server (NTRS)

Perry, Bruce; Anderson, Molly

2015-01-01

The Cascade Distillation Subsystem (CDS) is a rotary multistage distiller being developed to serve as the primary processor for wastewater recovery during long-duration space missions. The CDS could be integrated with a system similar to the International Space Station (ISS) Water Processor Assembly (WPA) to form a complete Water Recovery System (WRS) for future missions. Independent chemical process simulations with varying levels of detail have previously been developed using Aspen Custom Modeler (ACM) to aid in the analysis of the CDS and several WPA components. The existing CDS simulation could not model behavior during thermal startup and lacked detailed analysis of several key internal processes, including heat transfer between stages. The first part of this paper describes modifications to the ACM model of the CDS that improve its capabilities and the accuracy of its predictions. Notably, the modified version of the model can accurately predict behavior during thermal startup for both NaCl solution and pretreated urine feeds. The model is used to predict how changing operating parameters and design features of the CDS affects its performance, and conclusions from these predictions are discussed. The second part of this paper describes the integration of the modified CDS model and the existing WPA component models into a single WRS model. The integrated model is used to demonstrate the effects that changes to one component can have on the dynamic behavior of the system as a whole.

Association of Gay and Lesbian Psychiatrists

MedlinePlus

... Awards AGLP News Newsletter Archives Education Journal of Gay and Lesbian Mental Health GAP LGBT Online Curriculum ... an End to Harmful ‘Religious Freedom’ Laws...> WPA: Gay “Cures” Are Harmful And Don’t Work See ...

NAWIG News: The Quarterly Newsletter of the Native American Wind Interest Group, Summer 2007

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

DOE's Wind Powering America program has initiated a quarterly NAWIG newsletter to present Native American wind information, including projects, interviews with pioneers, issues, WPA activities, and related events.

Parmitano in U.S. Laboratory

NASA Image and Video Library

2013-07-30

ISS036-E-027387 (29 July 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, performs maintenance on the Water Pump Assembly 2 / Thermal Control System (WPA2/TCS) in the Columbus laboratory of the International Space Station.

Parmitano in U.S. Laboratory

NASA Image and Video Library

2013-07-30

ISS036-E-027389 (29 July 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, performs maintenance on the Water Pump Assembly 2 / Thermal Control System (WPA2/TCS) in the Columbus laboratory of the International Space Station.

Performance of WPA Conductivity Sensor during Two-Phase Fluid Flow in Microgravity

NASA Technical Reports Server (NTRS)

Carter, Layne; O'Connor, Edward W.; Snowdon, Doug

2003-01-01

The Conductivity Sensor designed for use in the Node 3 Water Processor Assembly (WPA) was based on the existing Space Shuttle application for the fuel cell water system. However, engineering analysis has determined that this sensor design is potentially sensitive to two-phase fluid flow (gadliquid) in microgravity. The source for this sensitivity is the fact that gas bubbles will become lodged between the sensor probe and the wall of the housing without the aid of buoyancy in l-g. Once gas becomes lodged in the housing, the measured conductivity will be offset based on the volume of occluded gas. A development conductivity sensor was flown on the NASA Microgravity Plan to measure the offset, which was determined to range between 0 and 50%. Based on these findings, a development program was initiated at the sensor s manufacturer to develop a sensor design fully compatible with two-phase fluid flow in microgravity.

77 FR 40081 - Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA) and Central Planning...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... environmental impacts resulting from the Deepwater Horizon event, BOEM conducted an extensive search for... events, including a low- probability catastrophic event associated with a proposed lease sale and a...

Columbus Thermal Control System (TCS) Degassing Operations

NASA Image and Video Library

2013-07-29

ISS036-E-026213 (29 July 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, performs maintenance on the Water Pump Assembly 2 / Thermal Control System (WPA2/TCS) in the Columbus laboratory of the International Space Station.

Garan performs TCS Water Loop Degassing in Columbus

NASA Image and Video Library

2011-04-08

ISS027-E-011325 (8 April 2011) --- NASA astronaut Ron Garan, Expedition 27 flight engineer, works on degassing the water loop of the running Water Pump Assembly 2 / Thermal Control System (WPA2/TCS) in the Columbus laboratory of the International Space Station.

Garan performs TCS Water Loop Degassing in Columbus

NASA Image and Video Library

2011-04-08

ISS027-E-011324 (8 April 2011) --- NASA astronaut Ron Garan, Expedition 27 flight engineer, works on degassing the water loop of the running Water Pump Assembly 2 / Thermal Control System (WPA2/TCS) in the Columbus laboratory of the International Space Station.

76 FR 70478 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... operations, except whole and partial blocks within the boundary of the Flower Garden Banks National Marine... partial blocks within the boundary of the Flower Garden Banks National Marine Sanctuary and whole and...

Identification of host genes linked with the survivability of chickens infected with recombinant viruses possessing H5N1 surface antigens from a highly pathogenic avian influenza virus.

PubMed

Uchida, Yuko; Watanabe, Chiaki; Takemae, Nobuhiro; Hayashi, Tsuyoshi; Oka, Takehiko; Ito, Toshihiro; Saito, Takehiko

2012-03-01

Seventeen recombinant viruses were generated by a reverse genetic technique to elucidate the pathogenicity of highly pathogenic avian influenza viruses (HPAIVs) in chickens. The recombinant viruses generated possessed hemagglutinin (HA) and neuraminidase (NA) genes from an HPAIV. Other segments were combinations of the genes from an HPAIV and two low-pathogenic avian influenza viruses (LPAIVs) derived from chicken (LP) and wild bird (WB). Exchange of whole internal genes from an HPAIV with those of an LPAIV resulted in a significant extension of the survival time following intranasal infection of the chickens with the recombinants. Survival analysis demonstrated that the exchange of a gene segment affected survivability of the chickens with statistical significance. The analysis revealed three groups of recombinants with various gene constellations that depended upon the survivability of the infected chickens. Recombinants where the PA gene was exchanged from LP to WB in the LP gene background, LP (W/PA), did not kill any chickens. LP (W/PA) replicated less efficiently both in vitro and in vivo, suggesting that the intrinsic replication ability of LP (W/PA) affects pathogenicity; however, such a correlation was not seen for the other recombinants. Microarray analysis of the infected chicken lungs indicated that the expression of 7 genes, CD274, RNF19B, OASL, ZC3HAV1 [corrected] , PLA2G6, GCH1, and USP18, correlated with the survivability of the chickens infected (P < 0.01). Further analysis of the functions of these genes in chickens would aid in the understanding of host gene responses following fatal infections by HPAIVs.

Phylogenetic analysis of Archaea in the deep-sea sediments of west Pacific Warm Pool.

PubMed

Wang, Peng; Xiao, Xiang; Wang, Fengping

2005-06-01

Archaea are known to play important roles in carbon cycling in marine sediments. The main compositions of archaeal community in five deep-sea sediment samples collected from west Pacific Warm Pool area (WP-0, WP-1, WP-2, WP-3, WP-4), and in five sediment layers (1 cm-, 3 cm-, 6 cm-, 10 cm-, 12 cm- layer) of the 12 cm sediment core of WP-0 were checked and compared by denaturing gradient gel electrophoresis and 16 S rRNA gene sequencing. It was revealed that all the deep-sea sediment samples checked contained members of non-thermophilic marine group I crenarchaeota as the predominant archaeal group. To further detect groups of archaea possibly relating with C1 metabolism, PCR amplification was carried out using primers targeting methane-oxidizing archaea. Although no methane-oxidizing archaea was detected, a group of novel archaea (named as WPA) was instead identified from all these five WP samples by clone analysis. They could be placed in the euryarchaeota kingdom, separated into two distinct groups, the main group was peripherally related with methanogens, the other group related with Thermoplasma. The vertical distributions of WPA, archaea and bacteria along the WP-0 sediment column were determined by quantitative-PCR. It was found that bacteria dominated at all depths, the numbers of bacteria were 10-10(4) times more than those of archaea. The proportion of archaea versus bacteria had a depth related increasing tendency, it was lowest at the first layer (0.01%), reached highest at the 12 cm- layer (10%). WPA only constituted a small proportion of the archaeal community (0.05% to 5%) of west Pacific Warm Pool sediment.

A holistic framework for design of cost-effective minimum water utilization network.

PubMed

Wan Alwi, S R; Manan, Z A; Samingin, M H; Misran, N

2008-07-01

Water pinch analysis (WPA) is a well-established tool for the design of a maximum water recovery (MWR) network. MWR, which is primarily concerned with water recovery and regeneration, only partly addresses water minimization problem. Strictly speaking, WPA can only lead to maximum water recovery targets as opposed to the minimum water targets as widely claimed by researchers over the years. The minimum water targets can be achieved when all water minimization options including elimination, reduction, reuse/recycling, outsourcing and regeneration have been holistically applied. Even though WPA has been well established for synthesis of MWR network, research towards holistic water minimization has lagged behind. This paper describes a new holistic framework for designing a cost-effective minimum water network (CEMWN) for industry and urban systems. The framework consists of five key steps, i.e. (1) Specify the limiting water data, (2) Determine MWR targets, (3) Screen process changes using water management hierarchy (WMH), (4) Apply Systematic Hierarchical Approach for Resilient Process Screening (SHARPS) strategy, and (5) Design water network. Three key contributions have emerged from this work. First is a hierarchical approach for systematic screening of process changes guided by the WMH. Second is a set of four new heuristics for implementing process changes that considers the interactions among process changes options as well as among equipment and the implications of applying each process change on utility targets. Third is the SHARPS cost-screening technique to customize process changes and ultimately generate a minimum water utilization network that is cost-effective and affordable. The CEMWN holistic framework has been successfully implemented on semiconductor and mosque case studies and yielded results within the designer payback period criterion.

The 5/95 Gap on the dissemination of mental health research: The World Psychiatric Association (WPA) task force report on project with editors of low and middle income (LAMI) countries.

PubMed

de Jesus Mari, J; Patel, V; Kieling, C; Anders, M; Jakovljevi, M; Lam, L C; Lotaief, F; Mendlowicz, M V; Okulat, G; Sathyanarayana Rao, T S; Tamam, L; Tyrer, P; Herrman, H

2009-02-01

The World Psychiatric Association (WPA) Task Force and a small group previously convened by the WPA publications committee initiated three activities between 2006-2008 that aimed to respond to the need for greater support for psychiatry journals in LAMI countries. In a joint venture with participants from the Global Mental Health Movement the Task Force editors from LAMI countries in Africa, Asia, Eastern Europe and Latin America were contacted to identify potential journals to target for indexation (Medline and ISI). The committee analyzed the editors' applications on the following criteria: a) geographical representativeness; b) affiliation to a professional mental health society; c) regular publication of at least 4 issues per year over the past few years; d) comprehensive national and international editorial boards; e) publication of original articles, or at least abstracts, in English; f) some level of current indexation; g) evidence of a good balance between original and review articles in publications; and h) a friendly access website. The committee received 26 applications (11 from Latin America, 7 from Central Europe, 4 from Asia and 4 from Africa), and selected 8 journals, 2 from each geographical area, on the basis of the overall scores obtained for the items mentioned, to participate in an editors meeting held in Prague in September 2008. The aims of the committee are twofold: a) to concentrate support for those selected journals; and b) to assist all LAMI mental health editors in improving the quality of their journals and fulfilling the requirements for full indexation. This report summarizes the procedures conducted by the committee, the assessment of the current non-indexed journals, and offers suggestions for further action.

Water Processing Assembly Particulate Filter Remove and Replace (R&R)

NASA Image and Video Library

2013-07-12

ISS036-E-018008 (12 July 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, removes and replaces the particulate filter for the Water Pump Assembly 2 (WPA2) in Tranquility (also called Node 3) on the International Space Station.

Water Processing Assembly Particulate Filter Remove and Replace (R&R)

NASA Image and Video Library

2013-07-12

ISS036-E-018007 (12 July 2013) --- European Space Agency astronaut Luca Parmitano, Expedition 36 flight engineer, removes and replaces the particulate filter for the Water Pump Assembly 2 (WPA2) in Tranquility (also called Node 3) on the International Space Station.

Validating Future Force Performance Measures (Army Class): End of Training Longitudinal Validation

DTIC Science & Technology

2009-09-01

Organization 66 Canal Center Plaza, Suite 700 Alexandria, Virginia 22314 8 . PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING...4 Table B. 8 . Intercorrelations among RBI Scale Scores...12. Intercorrelations among WPA Dimension and Facet Scores ...................................... 8 x xi CONTENTS (continued) Page

Wind Powering America's Regional Stakeholder Meetings and Priority State Reports: FY11 Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-06-01

Beginning in 2010, DOE conducted an assessment of Wind Powering America (WPA) activities to determine whether the methods the department had used to help grow the wind industry to provide 2% of the nation's electrical energy should be the same methods used to achieve 20% of the nation's energy from wind (as described in the report 20% Wind Energy by 2030: Increasing Wind Energy's Contribution to U.S. Electricity Supply). After the assessment, it was determined that the initiative's state-based activities should be phased out as part of a shift to regional-based approaches. To assist with this transition, WPA hosted amore » series of 1-day regional meetings at six strategic locations around the country and a single teleconference for island states, U.S. territories, and remote communities. This report summarizes the results of the inaugural regional meetings and the state reports with a focus on ongoing wind deployment barriers in each region.« less

Wind Powering America's Regional Stakeholder Meetings and Priority State Reports: FY11 Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baring-Gould, Ian

2013-06-01

Beginning in 2010, DOE conducted an assessment of Wind Powering America (WPA) activities to determine whether the methods the department had used to help grow the wind industry to provide 2% of the nation's electrical energy should be the same methods used to achieve 20% of the nation's energy from wind (as described in the report 20% Wind Energy by 2030: Increasing Wind Energy's Contribution toU.S. Electricity Supply). After the assessment, it was determined that the initiative's state-based activities should be phased out as part of a shift to regional-based approaches. To assist with this transition, WPA hosted a seriesmore » of 1-day regional meetings at six strategic locations around the country and a single teleconference for island states, U.S. territories, and remote communities.This report summarizes the results of the inaugural regional meetings and the state reports with a focus on ongoing wind deployment barriers in each region.« less

Columbus Payloads Flow Rate Anomalies

NASA Technical Reports Server (NTRS)

Quaranta, Albino; Bufano, Gaetana; DePalo, Savino; Holt, James M.; Szigetvari, Zoltan; Palumberi, Sergio; Hinderer, S.

2011-01-01

The Columbus Active Thermal Control System (ATCS) is the main thermal bus for the pressurized racks working inside the European laboratory. One of the ATCS goals is to provide proper water flow rate to each payload (P/L) by controlling actively the pressure drop across the common plenum distribution piping. Overall flow measurement performed by the Water Pump Assembly (WPA) is the only flow rate monitor available at system level and is not part of the feedback control system. At rack activation the flow rate provided by the system is derived on ground by computing the WPA flow increase. With this approach, several anomalies were raised during these 3 years on-orbit, with the indication of low flow rate conditions on the European racks FSL, BioLab, EDR and EPM. This paper reviews the system and P/Ls calibration approach, the anomalies occurred, the engineering evaluation on the measurement approach and the accuracy improvements proposed, the on-orbit test under evaluation with NASA and finally discusses possible short and long term solutions in case of anomaly confirmation.

78 FR 45557 - Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA) Oil and Gas Lease Sale...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... and partial blocks within the boundary of the Flower Garden Banks National Marine Sanctuary (i.e., the... within the boundary of the Flower Garden Banks National Marine Sanctuary (i.e., the boundary as of the...

77 FR 67394 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA) Lease Sale 233...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... baseline conditions and potential environmental effects of oil and natural gas leasing, exploration...://www.boem.gov/Environmental-Stewardship/Environmental-Assessment/NEPA/nepaprocess.aspx . Several.../Environmental-Stewardship/Environmental-Assessment/NEPA/nepaprocess.aspx . Comments: Federal, state, and local...

76 FR 36571 - Bowdoin National Wildlife Refuge Complex, Malta, MT; Comprehensive Conservation Plan

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... fishery due to high salinity levels or shallow water depth. Excluding Holm WPA, the remaining complex is... Thibadeau, and five alternatives for addressing the salinity and blowing salts issue on Bowdoin National... Alternative 2--Divestiture (proposed action). Alternatives for Salinity and Blowing Salts on Bowdoin National...

36 CFR 7.97 - Golden Gate National Recreation Area.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: (i) Crissy Field Wildlife Protection Area (WPA): Dog walking restricted to on-leash only in the area... powerless flight is allowed at times and locations designated by the superintendent, pursuant to the terms... open to bicycle use. (ii) Operating a bicycle on designated bicycle routes between sunset and sunrise...

Composition as Management Science: Toward a University without a WPA.

ERIC Educational Resources Information Center

Bousquet, Marc

2002-01-01

Surveys the degree to which the managerial subjectivity predominates in composition studies, distorting the field's understanding of "materialism" and "critique" to the point that it consistently attempts to offer "solutions" to its "labor problem" without accounting for the historical reality of organized academic labor. Claims that "change" in…

The Rhetoric of the Paneled Page: Comics and Composition Pedagogy

ERIC Educational Resources Information Center

Sealey-Morris, Gabriel

2015-01-01

While comics have received widespread acceptance as a literary genre, instructors and scholars in Rhetoric and Composition have been slower to adopt comics, largely because of a lingering difficulty understanding how the characteristics of the form relate to our work in the classroom. Using as guides the "WPA Outcomes Statement for First-Year…

77 FR 44671 - Notice of Availability of the Proposed Notice of Sale for Outer Continental Shelf (OCS) Oil and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... Planning Area (WPA) in the Gulf of Mexico; Correction AGENCY: Bureau of Ocean Energy Management (BOEM), Interior. ACTION: Notice; correction. SUMMARY: The Bureau of Ocean Energy Management published a notice... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Notice of Availability of the...

77 FR 40380 - Outer Continental Shelf, Gulf of Mexico, Oil and Gas Lease Sales, Western Planning Area Lease...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... Deepwater Horizon event. The WPA/CPA Supplemental EIS analysis will focus on updating the baseline conditions and potential environmental effects of oil and natural gas leasing, exploration, development, and... Supplemental EIS analysis will focus on the potential environmental effects of oil and natural gas leasing...

78 FR 42544 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sale, Western Planning...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-16

... Prepare a Supplemental Environmental Impact Statement (EIS) SUMMARY: Consistent with the regulations... 248; Central Planning Area (CPA) Lease Sales 227, 231, 235, 241, and 247, Final Environmental Impact... Supplemental Environmental Impact Statement (OCS EIS/EA BOEM 2013-0118) (WPA 233/CPA 231 Supplemental EIS). The...

76 FR 14984 - Sunkhaze Meadows National Wildlife Refuge, Penobscot, Kennebec, and Waldo Counties, ME, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

..., wildlife observation and photography, and environmental education and interpretation. We will review and... Sunkhaze Meadows NWR and Carlton Pond WPA. We will conduct the environmental review of this project and..., including American woodcock, red-winged blackbird, and bobolink. The Sandy Stream Unit is mainly comprised...

Theorizing Feminist Pragmatic Rhetoric as a Communicative Art for the Composition Practicum

ERIC Educational Resources Information Center

Ryan, Kathleen J.; Graban, Tarez Samra

2009-01-01

This article uses the convergence of our positionings as feminists, pragmatists, and rhetoricians to theorize communicative gaps related to different beliefs about writing instruction as sites of generative dialogue. We offer a WPA/TA discourse model centered on productive resistance and on discursive power, to posit feminist pragmatic rhetoric as…

Notes from the Margins: WAC, WID, and the Politics of Place(ment)

ERIC Educational Resources Information Center

Cook, Paul G.

2014-01-01

This institutional autoethnography (IAE) explores the political and pedagogical dynamics of WPA and WAC/WID work within an exceedingly small, resolutely single-sex, and assuredly rural liberal arts campus ecology. Working within a theoretical framework informed by WAC/WID's historical commitment to increasing literacy in students from diverse…

Graffiti: The Use of the Familiar

ERIC Educational Resources Information Center

Whitehead, Jessie L.

2004-01-01

This Instructional Resources continues our 2004 series on forms of "public art" that included Susan Goetz Zwirn's contribution on images of work in the 1930s (March 2004), Carol Argiro's exploration of public sculpture (July 2004), and Mary Jane Zander's work on WPA post office murals (September 2004). This Instructional Resources explores an art…

Challenges with Operating a Water Recovery System (WRS) in the Microgravity Environment of the International Space Station (ISS)

NASA Technical Reports Server (NTRS)

Carter, Donald Layne

2017-01-01

The ISS WRS produces potable water from crew urine, crew latent, and Sabatier product water. This system has been operational on ISS since November 2008, producing over 30,000 L of water during that time. The WRS includes a Urine Processor Assembly (UPA) to produce a distillate from the crew urine. This distillate is combined with the crew latent and Sabatier product water and further processed by the Water Processor Assembly (WPA) to the potable water. The UPA and WPA use technologies commonly used on ISS for water purification, including filtration, distillation, adsorption, ion exchange, and catalytic oxidation. The primary challenge with the design and operation of the WRS has been with implementing these technologies in microgravity. The absence of gravity has created unique issues that impact the constituency of the waste streams, alter two-phase fluid dynamics, and increases the impact of particulates on system performance. NASA personnel continue to pursue upgrades to the existing design to improve reliability while also addressing their viability for missions beyond ISS.

Assessment of Service Life for Regenerative ECLSS Resin Beds

NASA Technical Reports Server (NTRS)

Cloud, Dale L.; Keilich, Maria C.; Polis, Peter C.; Yanczura, Stephen J.

2013-01-01

The International Space Station (ISS) Water Processor Assembly (WPA) and Oxygen Generation Assembly (OGA) manage and process water at various levels of cleanliness for multiple purposes. The effluent of theWPA and the influent of the OGA require water at very high levels of purity. The bulk of the water purification that occurs in both systems is performed by consumable activated carbon and ion exchange resin beds. Replacement beds must be available on orbit in order to continue the ISS critical processes of water purification and oxygen generation. Various hurdles exist in order to ensure viable spare resin beds. These include the characteristics of resin beds such as: storage environment, shelf life requirements, microbial growth, and variations in the levels and species of contaminants the beds are required to remove. Careful consideration has been given to match water models, bed capacities and spares traffic models to ensure that spares are always viable. The results of these studies and considerations, in particular, how shelf life requirements affect resin bed life management, are documented in this paper.

Integration of In-Flight and Post-Flight Water Monitoring Resources in Addressing the U.S. Water Processor Assembly Total Organic Carbon (TOC) Anomaly

NASA Technical Reports Server (NTRS)

Straub, John E., II; McCly, J. Torin

2011-01-01

Beginning in June of 2010, the total organic carbon (TOC) concentration in the U.S. Water Processor Assembly (WPA) product water started to increase. A surprisingly consistent upward TOC trend was observed through weekly ISS total organic carbon analyzer (TOCA) monitoring. As TOC is a general organic compound indicator, return of water archive samples was needed to make better-informed crew health decisions on the specific compounds of concern and to aid in WPA troubleshooting. TOCA-measured TOC was more than halfway to the health-based screening limit of 3,000 g/L before archive samples were returned. Archive samples were returned on 22 Soyuz in September 2010 and on ULF5 in November of 2010. The samples were subjected to extensive analysis. Although TOC was confirmed to be elevated, somewhat surprisingly, none of the typical target compounds were detected at high levels. After some solid detective work, it was confirmed that the TOC was associated with a compound known as dimethylsilanediol (DMSD). DMSD is believed to be a breakdown product of siloxanes which are thought to be ubiquitous in the ISS atmosphere. A toxicological limit was set for DMSD and a forward plan was developed for conducting operations in the context of understanding the composition of the TOC measured in flight. This required careful consideration of existing ISS flight rules, coordination with ISS stakeholders, and development of a novel approach for the blending of inflight TOCA data with archive results to protect crew health. Among other challenges, team members had to determine how to utilize TOCA readings when making decisions about crew consumption of WPA water. This involved balancing very real concerns associated with the assumption that TOC would continue to be comprised of only DMSD. Demonstrated teamwork, multidisciplinary awareness, and innovative problem-solving were required to respond effectively to this anomaly.

Voicing the E in WOVE: Improving Reflection in ISUComm Foundation Courses ePortfolios

ERIC Educational Resources Information Center

Blakely, Barbara J.

2016-01-01

Using the literatures of student personal epistemology and approaches to learning, this article describes one WPA's deliberate pursuit of a deep approach to her learning about reflection. Other WPAs and instructors who have encountered an unexpected gap in their programs' or classes' work with reflection can revise documents and re-tune pedagogy…

76 FR 22139 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... additional comments and information regarding the Draft SEIS scheduled for May 17, 2011, and May 19, 2011. For additional information see SUPPLEMENTARY INFORMATION. FOR FURTHER INFORMATION CONTACT: For more information on the Draft SEIS or the public meetings, you may contact Mr. Gary D. Goeke, Bureau of Ocean...

Metagenre on the WPA-L: Transitional Threads as Nexus for Micro/Macro-Level Discourse on the Dissertation

ERIC Educational Resources Information Center

Pantelides, Kate

2015-01-01

In Carolyn Miller's "Rhetorical Community: The Cultural Basis of Genre," she revisits her assertion that genres are cultural artifacts and questions the nature of the relationship between micro-level, individual speech acts, and macro-level genres and systems. To demonstrate this relationship, I analyze "meta-genre" accounts of…

78 FR 21969 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA) Lease Sale 233...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... while ensuring availability of the document to the public, BOEM will primarily distribute digital copies... copies of the Final Supplemental EIS to several libraries along the Gulf Coast. To find out which libraries have copies of the Final Supplemental EIS for review, you may contact BOEM's Public Information...

75 FR 44276 - Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE); Cancellation of Oil and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-28

... Deepwater Horizon Oil Spill and Offshore Drilling, (the National Commission was established by Executive...); Cancellation of Oil and Gas Lease Sale 215 in the Western Planning Area (WPA) on the Outer Continental Shelf... measures to improve the safety of oil and gas development in Federal waters, provide greater environmental...

Write. Persist. Struggle: Sponsors of Writing and Workers' Education in the 1930s

ERIC Educational Resources Information Center

Mutnick, Deborah

2016-01-01

Organizations like the John Reed Clubs and the WPA Federal Writers' Project, as well as publications like "The New Masses" can be seen as "literacy sponsors" of the U.S. literary left in the 1930s, particularly the young, the working class, and African American writers. The vibrant, inclusionary, activist, literary culture of…

Status of the Regenerative ECLS Water Recovery System

NASA Technical Reports Server (NTRS)

Carter, Donald Layne

2010-01-01

The regenerative Water Recovery System (WRS) has completed its first full year of operation on the International Space Station (ISS). The major assemblies included in this system are the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of May 2010, and describes the technical challenges encountered and lessons learned over the past year.

Local History, Local Complexities: The First-Year Writing Curriculum at the University of Louisiana at Lafayette

ERIC Educational Resources Information Center

Ratliff, Clancy

2013-01-01

This profile describes a new WPA's choice to work incrementally to assess an inherited, fledgling First-Year Writing curriculum at the University of Louisiana at Lafayette and change it over a three-year period with continual stakeholder involvement. The methods used for assessment were two rounds of instructor surveys and three rounds of direct…

The Activist WPA in Action: A Profile of the Firstyear Writing Program at Eastern Michigan University

ERIC Educational Resources Information Center

Irvin, L. Lennie

2009-01-01

This writing program profile examines the work of Dr. Linda Adler-Kassner and the ways in which she has redefined writing and the place of first-year writing at her university. The profile highlights Adler-Kassner's development of an "open systems" curriculum and her use of assessment for program visibility and continuous program…

An Early Start: WPA Emergency Nursery Schools in Texas, 1934-1943

ERIC Educational Resources Information Center

Burlbaw, Lynn Matthew

2009-01-01

This paper begins with an overview of the location and types of nursery schools reported to be operating in Texas between 1934 and 1943. The author reports on the results of the analysis of the photographs used in this study. The analysis is supported and contextualized by the use of references from federal documents and other publications…

Expanded Enlistment Eligibility Metrics (EEEM): Recommendations on a Non-Cognitive Screen for New Soldier Selection

DTIC Science & Technology

2010-07-01

applicants and is pursing further research on the WPA. An operational test and evaluation ( IOT &E) has been initiated to evaluate the new screen...initial operational test and evaluation ( IOT &E) starting in fall 2009. vii EXPANDED ENLISTMENT ELIGIBILITY METRICS (EEEM): RECOMMENDATIONS ON A NON...Evaluation of a Performance Screen for IOT &E ..................................... 49 Approach

From Zero to Sixty: A Survey of College Writing Teachers' Grading Practices and the Affect of Failed Performance

ERIC Educational Resources Information Center

Babb, Jacob; Corbett, Steven J.

2016-01-01

Drawing on results from a survey distributed nationally through the WPA and WCenter listservs, we examine the affective aspect of failure in teachers' responses to student writing, aiming to pinpoint teachers' perceptions of why students fail. Overall, we posit that writing studies needs to pay closer attention to teachers' emotional responses to…

In-Flight Water Quality Monitoring on the International Space Station (ISS): Measuring Biocide Concentrations with Colorimetric Solid Phase Extraction (CSPE)

NASA Technical Reports Server (NTRS)

Gazda, Daniel B.; Schultz, John R.; Siperko, Lorraine M.; Porter, Marc D.; Lipert, Robert J.; Flint, Stephanie M.; McCoy, J. Torin

2011-01-01

The colorimetric water quality monitoring kit (CWQMK) was delivered to the International Space Station (ISS) on STS-128/17A and was initially deployed in September 2009. The kit was flown as a station development test objective (SDTO) experiment to evaluate the acceptability of colorimetric solid phase extraction (CSPE) technology for routine water quality monitoring on the ISS. During the SDTO experiment, water samples from the U.S. water processor assembly (WPA), the U.S. potable water dispenser (PWD), and the Russian system for dispensing ground-supplied water (SVO-ZV) were collected and analyzed with the CWQMK. Samples from the U.S. segment of the ISS were analyzed for molecular iodine, which is the biocide added to water in the WPA. Samples from the SVOZV system were analyzed for ionic silver, the biocide used on the Russian segment of the ISS. In all, thirteen in-flight analysis sessions were completed as part of the SDTO experiment. This paper provides an overview of the experiment and reports the results obtained with the CWQMK. The forward plan for certifying the CWQMK as operational hardware and expanding the capabilities of the kit are also discussed.

An Evaluation of Technology to Remove Problematic Organic Compounds from the International Space Station Potable Water

NASA Technical Reports Server (NTRS)

Rector, Tony; Metselaar, Carol; Peyton, Barbara; Steele, John; Michalek, William; Bowman, Elizabeth; Wilson, Mark; Gazda, Daniel; Carter, Layne

2014-01-01

Since activation of the Water Processor Assembly (WPA) on the International Space Station (ISS) in November of 2008, there have been three events in which the TOC (Total Organic Carbon) in the product water has increased to approximately 3 mg/L and has subsequently recovered. Analysis of the product water in 2010 identified the primary component of the TOC as dimethylsilanediol (DMSD). An investigation into the fate of DMSD in the WPA ultimately determined that replacement of both Multifiltration (MF) Beds is the solution to recovering product water quality. The MF Beds were designed to ensure that ionic breakthrough occurs before organic breakthrough. However, DMSD saturated both MF Beds in the series, requiring removal and replacement of both MF Beds with significant life remaining. Analysis of the MF Beds determined that the adsorbent was not effectively removing DMSD, trimethylsilanol, various polydimethylsiloxanes, or dimethylsulfone. Coupled with the fact that the current adsorbent is now obsolete, the authors evaluated various media to identify a replacement adsorbent as well as media with greater capacity for these problematic organic contaminants. This paper provides the results and recommendations of this collaborative study.

Global Cryptosporidium Loads from Livestock Manure.

PubMed

Vermeulen, Lucie C; Benders, Jorien; Medema, Gertjan; Hofstra, Nynke

2017-08-01

Understanding the environmental pathways of Cryptosporidium is essential for effective management of human and animal cryptosporidiosis. In this paper we aim to quantify livestock Cryptosporidium spp. loads to land on a global scale using spatially explicit process-based modeling, and to explore the effect of manure storage and treatment on oocyst loads using scenario analysis. Our model GloWPa-Crypto L1 calculates a total global Cryptosporidium spp. load from livestock manure of 3.2 × 10 23 oocysts per year. Cattle, especially calves, are the largest contributors, followed by chickens and pigs. Spatial differences are linked to animal spatial distributions. North America, Europe, and Oceania together account for nearly a quarter of the total oocyst load, meaning that the developing world accounts for the largest share. GloWPa-Crypto L1 is most sensitive to oocyst excretion rates, due to large variation reported in literature. We compared the current situation to four alternative management scenarios. We find that although manure storage halves oocyst loads, manure treatment, especially of cattle manure and particularly at elevated temperatures, has a larger load reduction potential than manure storage (up to 4.6 log units). Regions with high reduction potential include India, Bangladesh, western Europe, China, several countries in Africa, and New Zealand.

Performance Evaluation of the ISS Water Processor Multifiltration Beds

NASA Technical Reports Server (NTRS)

Bowman, Elizabeth M.; Carter, Layne; Wilson, Mark; Cole, Harold; Orozco, Nicole; Snowdon, Doug

2012-01-01

The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Bed, which includes adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. The first Multifiltration Bed was replaced on ISS in July 2010 after initial indication of inorganic breakthrough. This bed was returned to ground in July 2011 for an engineering investigation. The water resident in the bed was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed. In addition, an unused Multifiltration Bed was evaluated after two years in storage to assess the generation of leachates during storage. This assessment was performed to evaluate the possibility that these leachates are impacting performance of the Catalytic Reactor located downstream of the Multifiltration Bed. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper.

76 FR 70473 - Outer Continental Shelf (OCS) Western Planning Area (WPA) Gulf of Mexico (GOM) Oil and Gas Lease...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... period of the lease term for blocks in water depths of 400 meters to less than 1,600 meters, (2) the minimum bonus bid has increased for blocks in water depths of 400 meters or deeper, (3) no deepwater... meters and (2) 400 meters or more. Successful Bidders: The BOEM requires each company that has been...

77 FR 65408 - Outer Continental Shelf (OCS) Western Planning Area (WPA) Gulf of Mexico (GOM) Oil and Gas Lease...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-26

... leases in depths less than 400 meters with an initial period longer than 5 years, royalty rates, minimum... $25.00 per acre or fraction thereof for blocks in water depths of less than 400 meters. $100.00 per acre or fraction thereof for blocks in water depths of 400 meters or deeper. Rental Rates Annual rental...

Wind for Schools Project Power System Brief, Wind Powering America Fact Sheet Series

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baring-Gould, I.

2009-05-01

Wind Powering America's (WPA's) Wind for Schools project uses a basic system configuration for each school project. The system incorporates a single SkyStream wind turbine, a 70-ft guyed tower, disconnect boxes at the base of the turbine and at the school, and an interconnection to the school's electrical system. This document provides a detailed description of each system component.

77 FR 43355 - Notice of Availability of the Proposed Notice of Sale for Outer Continental Shelf (OCS) Oil and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... Proposed Notice of Sale for Outer Continental Shelf (OCS) Oil and Gas Lease Sale 229 in the Western...: Notice of Availability of the Proposed Notice of Sale for Proposed Sale 229. SUMMARY: BOEM announces the availability of the Proposed Notice of Sale (NOS) for proposed Sale 229 in the WPA. This sale will be the first...

78 FR 45558 - Western Gulf of Mexico Planning Area (WPA) Outer Continental Shelf (OCS) Oil and Gas Lease Sale...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... meters Initial period 0 to $25.00 per acre or fraction thereof for blocks in water depths less than 400 meters $100.00 per acre or fraction thereof for blocks in water depths of 400 meters or deeper BOEM will... specified minimum bid of $25.00 per acre or fraction thereof for blocks in water depths less than 400 meters...

12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING DEVELOPMENT. 'BURBANK FARM' ON RIGHT. TALL TREE TO RIGHT OF STREET LIGHT IS EUCALYPTUS ON WEST OF COTTAGE WHICH IS PLANNED FOR REMOVAL. 13. 'BURBANK FARM' SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED WAS LOWERED. WPA STONE RETAINING WALL AT BASE OF CUT. LOOKING SOUTHWEST. - Gold Ridge Farm, 7777 Bodega Avenue, Sebastopol, Sonoma County, CA

Global Cryptosporidium Loads from Livestock Manure

PubMed Central

2017-01-01

Understanding the environmental pathways of Cryptosporidium is essential for effective management of human and animal cryptosporidiosis. In this paper we aim to quantify livestock Cryptosporidium spp. loads to land on a global scale using spatially explicit process-based modeling, and to explore the effect of manure storage and treatment on oocyst loads using scenario analysis. Our model GloWPa-Crypto L1 calculates a total global Cryptosporidium spp. load from livestock manure of 3.2 × 1023 oocysts per year. Cattle, especially calves, are the largest contributors, followed by chickens and pigs. Spatial differences are linked to animal spatial distributions. North America, Europe, and Oceania together account for nearly a quarter of the total oocyst load, meaning that the developing world accounts for the largest share. GloWPa-Crypto L1 is most sensitive to oocyst excretion rates, due to large variation reported in literature. We compared the current situation to four alternative management scenarios. We find that although manure storage halves oocyst loads, manure treatment, especially of cattle manure and particularly at elevated temperatures, has a larger load reduction potential than manure storage (up to 4.6 log units). Regions with high reduction potential include India, Bangladesh, western Europe, China, several countries in Africa, and New Zealand. PMID:28654242

Microbiological Characterization of the International Space Station Water Processor Assembly External Filter Assembly S/N 01

NASA Technical Reports Server (NTRS)

Weir, Natalee; Wilson, Mark; Yoets, Airan; Yoets, Airan; Molina, Thomas; Bruce, Rebekah; Sitler, Glenn; Carter, Layne

2012-01-01

The External Filter Assembly (EFA) S/N 01 is a mesh screen filter with a pore size of approximately 300 micron that was installed in the International Space Station (ISS) Water Processor Assembly (WPA) between the Waste Tank and the Mostly Liquid Separator (MLS) on February 11, 2010 to protect clearances in the MLS solenoid valve SV_1121_3. A removal & replacement of the EFA Filter was performed on March 22, 2011 in response to increasing pressure across the Waste Tank solenoid valve SV_1121_1 and the EFA Filter. The EFA Filter was returned on ULF6 and received in the Boeing Huntsville Laboratory on June 13, 2011. The filter was aseptically removed from the housing, and the residual water was collected for enumeration and identification of bacteria and fungi. Swab samples of the filter surface were also collected for microbiological enumeration and identification. Sample analyses were performed by Boeing Huntsville Laboratory and NASA Johnson Space Center Microbiology for comparison. Photographic documentation of the EFA filter was performed using a stereo microscope and environmental scanning electron microscope. This paper characterizes the amount and types of microorganisms on the filter surface and in the residual water from the filter housing following 1 year of utilization in the ISS WPA.

Photographic copy of historic photograph, by Corps of Engineers, U.S. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of historic photograph, by Corps of Engineers, U.S. Army, November 19, 1943 (original in possession of Corps of Engineers, U.S. Army, Pittsburgh District, Engineering Division files) Unit 6, view of WPA masonry wall and dike upstream from Central Avenue Bridge - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

Lessons learned in developing community mental health care in Latin American and Caribbean countries

PubMed Central

RAZZOUK, DENISE; GREGÓRIO, GUILHERME; ANTUNES, RENATO; MARI, JAIR DE JESUS

2012-01-01

This paper summarizes the findings for the Latin American and Caribbean countries of the WPA Task Force on Steps, Obstacles and Mistakes to Avoid in the Implementation of Community Mental Health Care. It presents an overview of the provision of mental health services in the region; describes key experiences in Argentina, Belize, Brazil, Chile, Cuba, Jamaica and Mexico; and discusses the lessons learned in developing community mental health care. PMID:23024680

Status of the Regenerative ECLSS Water Recovery System

NASA Technical Reports Server (NTRS)

Carter, Donald Layne

2009-01-01

NASA has completed the delivery of the regenerative Water Recovery System (WRS) for the International Space Station (ISS). The major assemblies included in this system are the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the final effort to deliver the hardware to the Kennedy Space Center for launch on STS-126, the on-orbit status as of April 2009, and describes some of the technical challenges encountered and lessons learned over the past year.

The Story Behind the Numbers: Lessons Learned from the Integration of Monitoring Resources in Addressing an ISS Water Quality Anomaly

NASA Technical Reports Server (NTRS)

McCoy, Torin; Flint, Stephanie; Straub, John, II; Gazda, Dan; Schultz, John

2011-01-01

Beginning in June of 2010 an environmental mystery was unfolding on the International Space Station (ISS). The U.S. Water Processor Assembly (WPA) began to produce water with increasing levels of total organic carbon (TOC). A surprisingly consistent upward TOC trend was observed through weekly in-flight total organic carbon analyzer (TOCA) monitoring. As TOC is a general organics indicator, return of water archive samples was needed to make better-informed crew health decisions and to aid in WPA troubleshooting. TOCA-measured TOC was more than halfway to its health-based screening limit before archive samples could be returned on Soyuz 22 and analyzed. Although TOC was confirmed to be elevated, somewhat surprisingly, none of the typical target compounds were the source. After some solid detective work, it was confirmed that the TOC was associated with a compound known as dimethylsilanediol (DMSD). DMSD is believed to be a breakdown product of silicon-containing compounds present on ISS. A toxicological limit was set for DMSD and a forward plan developed for operations given this new understanding of the source of the TOC. This required extensive coordination with ISS stakeholders and innovative use of available in-flight and archive monitoring resources. Behind the numbers and scientific detail surrounding this anomaly, there exists a compelling story of multi-disciplinary awareness, teamwork, and important environmental lessons learned.

NAWIG News: The Quarterly Newsletter of the Native American Wind Interest Group, Fall 2008, Wind & Hydropower Technologies Program (Brochure)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2008-09-01

As part of its Native American outreach, DOE?s Wind Powering America program produces a newsletter to present Native American wind information, including projects, interviews with pioneers, issues, WPA activities, and related events. This issue features an interview with Dave Danz, a tribal planner for the Grand Portage Band of Chippewa in northeastern Minnesota, and a feature on the new turbine that powers the KILI radio station on the Pine Ridge Reservation.

The Design of a Propeller for a U.S. Coast Guard Icebreaker Tugboat

DTIC Science & Technology

1975-10-01

series as investigated by Van Lammeren, Van Manen , and Oosterveld . This propeller series, commonly referred to as the K’jgeningen B-screw series...RtFEKENCES Van Lammeren, W.P.A., Van Manen , J.D., and Oosterveld, M.W.C., "The Wageningen B-Screw Series," Transactions of the Society of Naval Architects...forces has been reported by Van Gunsteren and Pronk . They investigated both single and twin screw ships of various types and the results are

Wind for Schools Project Power System Brief

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2007-08-01

This fact sheet provides an overview of the system components of a Wind Powering America Wind for Schools project. Wind Powering America's (WPA's) Wind for Schools project uses a basic system configuration for each school project. The system incorporates a single SkyStream(TM) wind turbine, a 70-ft guyed tower, disconnect boxes at the base of the turbine and at the school, and an interconnection to the school's electrical system. A detailed description of each system component is provided in this document.

Management of the Post-Shuttle Extravehicular Mobility Unit (EMU) Water Circuits

NASA Technical Reports Server (NTRS)

Steele, John W.; Etter, David; Rector, Tony; Hill, Terry; Wells, Kevin

2011-01-01

The EMU incorporates two separate water circuits for the rejection of metabolic heat from the astronaut and the cooling of electrical components. The first (the Transport Water Loop) circulates in a semi-closed-loop manner and absorbs heat into a Liquid Coolant and Ventilation Garment (LCVG) warn by the astronaut. The second (the Feed Water Loop) provides water to a cooling device (Sublimator) with a porous plate, and that water subsequently sublimates to space vacuum. The cooling effect from the sublimation of this water translates to a cooling of the LCVG water that circulates through the Sublimator. Efforts are underway to streamline the use of a water processing kit (ALCLR) that is being used to periodically clean and disinfect the Transport Loop Water. Those efforts include a fine tuning of the duty cycle based on a review of prior performance data as well as an assessment of a fixed installation of this kit into the EMU backpack or within on-orbit EMU interface hardware. Furthermore, testing is being conducted to ensure compatibility between the International Space Station (ISS) Water Processor Assembly (WPA) effluent and the EMU Sublimator as a prelude to using the WPA effluent as influent to the EMU Feed Water loop. This work is undertaken to reduce the crew-time and logistics burdens for the EMU, while ensuring the long-term health of the EMU water circuits for a post-Shuttle 6-year service life.

Updated Performance Evaluation of the ISS Water Processor Multifiltration Beds

NASA Technical Reports Server (NTRS)

Bowman, Elizabeth M.; Carter, Layne; Carpenter, Joyce; Orozco, Nicole; Weir, Natalee; Wilson, Mark

2014-01-01

The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Beds, which include adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. Two Multifiltration Beds (MF Beds) were replaced on ISS in July 2010 after initial indication of inorganic breakthrough of the first bed and an increasing Total Organic Carbon (TOC) trend in the product water. The first bed was sampled and analyzed Sept 2011 through March 2012. The second MF Bed was sampled and analyzed June 2012 through August 2012. The water resident in the both beds was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed in addition to microbial analysis. Analysis of the second bed will be compared to results from the first bed to provide a comprehensive overview of how the Multifiltration Beds function on orbit. New data from the second bed supplements the analysis of the first bed (previously reported) and gives a more complete picture of breakthrough compounds, resin breakdown products, microbial activity, and difficult to remove compounds. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper.

The lean ergonomics in green design of crude palm oil plant

NASA Astrophysics Data System (ADS)

Huda, L. N.; Matondang, R.

2018-02-01

Ergonomics can help manufacturing and industrial engineersmaximum work output without physical harm to workers.Physiology, biomechanics, anthropometrics, and allocation are the areas of ergonomics most useful to manufacturing in apllying the concept of Lean and Green in manufacturing. These systems require efficient production and low use of resources such as energy and material. Its philosophy encourage worker to look at waste. This concept is applied in one of national plant of Crude Palm Oil (CPO) that located in North Sumatera. The problem found in the company are the working posture and excessive workload of the workers. These conditions are affects to the their job performance. The study was carried out by evaluated the worker body position using the Work Posture Assesment (WPA) and Biomechanics method. The WPA results shows the operator’s working position was mostly bent more than 30 degrees. This indicates that almost all workers are felt musculoskeletal disorders during work hours. While the biomechanics analysis found the significant relation between the values of Recommended Weight Limit (RWL) and Lifting Index (LI) which the increase of RWL value will decrease the LI value. This indicated that the recommended load for a worker under certain circumstances affects the appointment made so as not to contain the risk of spinal injury. In fact these condition are due to in-efficiency in production which can be maintaned the green design of CPO plant by improving the existing work.

Management of the Post-Shuttle Extravehicular Mobility Unit (EMU) Water Circuits

NASA Technical Reports Server (NTRS)

Steele, John W.; Etter, David; Rector, Tony; Hill, Terry; Wells, Kevin

2012-01-01

The EMU incorporates two separate water circuits for the rejection of metabolic heat from the astronaut and the cooling of electrical components. The first (the Transport Water Loop) circulates in a semi-closed-loop manner and absorbs heat into a Liquid Coolant and Ventilation Garment (LCVG) worn by the astronaut. The second (the Feed-water Loop) provides water to a cooling device (Sublimator) with a porous plate, and that water subsequently sublimates to space vacuum. The cooling effect from the sublimation of this water translates to a cooling of the LCVG water that circulates through the Sublimator. Efforts are underway to streamline the use of a water processing kit (ALCLR) that is being used to periodically clean and disinfect the Transport Loop Water. Those efforts include a fine tuning of the duty cycle based on a review of prior performance data as well as an assessment of a fixed installation of this kit into the EMU backpack, within on-orbit EMU interface hardware or as a stand-alone unit. Furthermore, testing is being conducted to ensure compatibility between the International Space Station (ISS) Water Processor Assembly (WPA) effluent and the EMU Sublimator as a prelude to using the WPA effluent as influent to the EMU Feed Water loop. This work is undertaken to reduce the crewtime and logistics burdens for the EMU, while ensuring the long-term health of the EMU water circuits for a 6-year service life.

Regional cooperation in South Asia in the field of mental health.

PubMed

Trivedi, Jitendra K; Goel, Dishanter; Kallivayalil, Roy A; Isaac, Mohan; Shrestha, Dhruba M; Gambheera, Harish C

2007-02-01

The South Asian region accounts for around one fourth of the world population and one fifth of psychiatrically ill patients in the world. The region lacks mental health policies and infrastructure. Issues like community care, trained manpower, patient satisfaction and better legislation have been a focus of attention in recent years. As this region is fast developing, cooperation is needed in the field of mental health to keep pace with the other areas. Cooperation is needed to develop culturally acceptable forms of psychotherapy and new technologies for delivery of mental health services. Another area of potential cooperation is the development of a classification of mental disorders that is more informative in our setting. The development of a mental health programme and its inclusion at various levels of health care delivery has also gained precedence. As most of countries in the area have limited financial resources, the funds are to be used in the most cost-effective manner, and for this a greater collaboration amongst the countries is needed. New research needs to be undertaken in the area especially to meet the local requirements and to understand diseases in a regional perspective, but research cannot be fruitful if regional cooperation is lacking. To enhance the cooperation in mental health, world bodies like the WPA will need to come forward and bring all the countries at a common platform. The WPA has done commendable work in this regard and has always extended support to the regional bodies to uplift the mental health in this region.

Indian Psychiatric Society-World Psychiatric Association - World Health Organization survey on usefulness of International Classification of Diseases-10

PubMed Central

Avasthi, Ajit; Grover, Sandeep; Maj, Mario; Reed, Geoffrey; Thirunavukarasu, M.; Garg, Uttam Chand

2014-01-01

Background: World Health Organization (WHO) is in the process of revising the International Classification of Diseases 10 (ICD-10). For increasing the acceptability of the ICD-11, WHO along with World Psychiatric Association (WPA), conducted a survey of psychiatrists around the world, in which 386 psychiatrists from India participated. Aim: To present the findings of “WPA-WHO Global Survey of Psychiatrists’ Attitudes toward Mental Disorders Classification” for Indian psychiatrists who participated in the survey as members of Indian Psychiatric Society. Methodology: The online survey was sent to qualified psychiatrists who are members of Indian Psychiatric Society and are residing in India. Results: Of the 1702 members who were urged to participate in the survey, 386 (22.7%) participated. Most(79%) of the psychiatrists opined that they use formal classificatory systems in their day-to-day clinical practice. ICD-10 was the most commonly (71%) followed classificatory system. Nearly half (48%) felt the need for only 10–30 categories for use in clinical settings and another 44% opined that 31-100 categories are required for use. Most of the participants (85%) suggested that a modified/simpler classificatory system should be designed for primary care practitioners. Similarly, the same number of participants (89%) argued that for maximum utility of a nosological system diagnostic criteria should provide flexible guidance that allows cultural variation and clinical judgement. About 75% opined that the diagnostic system they were using was difficult to apply across cultures. Conclusion: Findings of the survey suggest that classificatory systems are routinely used in day-to-day practice by most of the participating psychiatrists in India and most expect that future classificatory system should provide flexible guidance that allows cultural variation and clinical judgement. PMID:25568475

"Progress or Abuse--A Choice." A Study to Investigate the Need for Legislative and Administrative Actions Regarding Standards of Progress Provisions of the GI Bill and Class Session Requirements of the Veterans' Administration Regulations.

ERIC Educational Resources Information Center

Veterans Administration, Washington, DC.

The need for legislative and administrative action was examined in regard to the GI Bill and the satisfactory progress requirements and the "seat-time" requirements prescribed by regulation. Information is presented on the GI Bill Improvement Act of 1977 (P.L. 95-202), standards of progress of the veteran student, and contact time, or…

Wind Powering America Podcasts, Wind Powering America (WPA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2012-04-01

Wind Powering America and the National Association of Farm Broadcasters produce a series of radio interviews featuring experts discussing wind energy topics. The interviews are aimed at a rural stakeholder audience and are available as podcasts. On the Wind Powering America website, you can access past interviews on topics such as: Keys to Local Wind Energy Development Success, What to Know about Installing a Wind Energy System on Your Farm, and Wind Energy Development Can Revitalize Rural America. This postcard is a marketing piece that stakeholders can provide to interested parties; it will guide them to this online resource formore » podcast episodes.« less

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Wilson, Laura Labuda; Orozco, Nicole

2012-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment, and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of May 2011, and describes the technical challenges encountered and lessons learned over the past year.

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Pruitt, Jennifer; Brown, Christopher A.; Bazley, Jesse; Gazda, Daniel; Schaezler, Ryan; Bankers, Lyndsey

2016-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of May 2016 and describes the technical challenges encountered and lessons learned over the past year.

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Brown, Christopher; Orozco, Nicole

2014-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment, and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of June 2013, and describes the technical challenges encountered and lessons learned over the past year.

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Tobias, Barry; Orozco, Nicole

2012-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment, and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of June 2012, and describes the technical challenges encountered and lessons learned over the past year.

International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities

PubMed Central

DEB, SHOUMITRO; KWOK, HENRY; BERTELLI, MARCO; SALVADOR-CARULLA, LUIS; BRADLEY, ELSPETH; TORR, JENNIFER; BARNHILL, JARRET

2009-01-01

Psychotropic medications are used regularly to manage problem behaviours among people with intellectual disabilities. This causes concern because often these medications are used out of their licensed indications in this context. The WPA Section on Psychiatry of Intellectual Disability has recently developed an evidence and consensus-based international guide for practitioners for the use of psychotropic medications for problem behaviours among adults with intellectual disabilities. This guide advises on assessment of behaviours, producing a formulation, initiation of treatment, assessment of out-come and adverse effects, follow-up arrangements, and possibility of discontinuation of treatment. PMID:19812757

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Takada, Kevin; Gazda, Daniel; Brown, Christopher; Bazley, Jesse; Schaezler, Ryan; Bankers, Lyndsey

2017-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of June 2017 and describes the technical challenges encountered and lessons learned over the past year.

Status of ISS Water Management and Recovery

NASA Technical Reports Server (NTRS)

Carter, Layne; Pruitt, Jennifer; Brown, Christopher A.; Schaezler, Ryan; Bankers, Lyndsey

2015-01-01

Water management on ISS is responsible for the provision of water to the crew for drinking water, food preparation, and hygiene, to the Oxygen Generation System (OGS) for oxygen production via electrolysis, to the Waste & Hygiene Compartment (WHC) for flush water, and for experiments on ISS. This paper summarizes water management activities on the ISS US Segment, and provides a status of the performance and issues related to the operation of the Water Processor Assembly (WPA) and Urine Processor Assembly (UPA). This paper summarizes the on-orbit status as of May 2015 and describes the technical challenges encountered and lessons learned over the past two years.

44 CFR 206.437 - State administrative plan.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requests for advances of funds and reimbursement; (vii) Monitor and evaluate the progress and completion of... technical assistance as required to subgrantee(s); (xi) Comply with the administrative and audit requirements of 44 CFR parts 13 and 206; (xii) Provide quarterly progress reports to the Regional Administrator...

44 CFR 206.437 - State administrative plan.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requests for advances of funds and reimbursement; (vii) Monitor and evaluate the progress and completion of... technical assistance as required to subgrantee(s); (xi) Comply with the administrative and audit requirements of 44 CFR parts 13 and 206; (xii) Provide quarterly progress reports to the Regional Administrator...

5 CFR 9701.346 - Pay progression for new supervisors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Pay progression for new supervisors. 9701.346 Section 9701.346 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES... SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Performance-Based Pay § 9701.346 Pay...

Troposcatter Antenna Positioner

DTIC Science & Technology

1980-08-01

that ’ Z ’ WecT ie(hu1)s n 1) adue h atta t i vnt id() W= 41TRd(O0) (12) Using (10) twice, we get the second moment . 2S(W)e Wdw -21R 10 (0)( Papoulis...tu 4~e~eawd, deu~entpr,, te~ t and Le~ t ~td acqwiU’On Po4au6m in 4uappo’Lt oj Counand, Conto COuusuwi6 m lantettigexce (01) m40tie.6. Ted*tma and...275 - 7 4.] 󈧕 kL L. d TROPOSCATTER ANTENNA POSITIONR Finalechnical Iep t ." 6Sep 7-_Feb _W1 j( W. P /irkemeier F3 16O2 77-CQl48WpA 9. PERFORMING

Educational Model for Social Service Administration and Management. Summary Progress Report.

ERIC Educational Resources Information Center

Wright, Marjorie Brown

This paper constitutes a summary progress report on a short-term training course designed to provide social work bachelor's degree practitioners with the knowledge and skills necessary for administrative and managerial positions. Increasingly, social work graduates have reported moving into social service administration and managerial positions…

Batten Disease

MedlinePlus

... Drug Administration has approved the use of cerliponase alfa to slow the progression of symptoms in children ... Drug Administration has approved the use of cerliponase alfa to slow the progression of symptoms in children ...

Experiencing the Progress Report: An Analysis of Gender and Administration in Doctoral Candidature

ERIC Educational Resources Information Center

Mewburn, Inger; Cuthbert, Denise; Tokareva, Ekaterina

2014-01-01

Most universities around the world put in place administrative processes and systems to manage student progress. These processes usually involve filling out standardised forms and instruments: managerial tools intended to increase transparency, promote efficiency and ensure fairness by applying the same standards to all. The progress report is a…

2014 ISS Potable Water Characterization and Continuation of the DMSD Chronicle

NASA Technical Reports Server (NTRS)

Straub, John E., II; Plumlee, Debrah K.; Mudgett, Paul D.

2015-01-01

During 2014 the crews from Expeditions 38-41 were resident on the International Space Station (ISS). In addition to the U.S. potable water reclaimed from humidity condensate and urine, the other water supplies available for their use were Russian potable water reclaimed from condensate and Russian ground-supplied potable water. Beginning in June of 2014, and for the fourth time since 2010, the product water from the U.S. Water Processor Assembly (WPA) experienced a rise in the total organic carbon (TOC) level due to organic contaminants breaking through the water treatment process. Results from ground analyses of ISS archival water samples returned on Soyuz 38 confirmed that dimethylsilanediol (DMSD) was once again the contaminant responsible for the rise. With this confirmation in hand and based upon the low toxicity of DMSD, a waiver was approved to allow the crew to continue to consume the water after the TOC level exceeded the U.S. Segment limit of 3 mg/L. Several weeks after the WPA multifiltration beds were replaced, as anticipated based upon experience from previous rises, the TOC levels returned to below the method detection limit of the onboard TOC analyzer (TOCA). This paper presents and discusses the chemical analysis results for the ISS archival potable water samples returned in 2014 and analyzed by the Johnson Space Center's Toxicology and Environmental Chemistry laboratory. These results showed compliance with ISS potable water quality standards and indicated that the potable water supplies were acceptable for crew consumption. Although DMSD levels were at times elevated they remained well below the 35 mg/L health limit, so continued consumption of the U.S potable water was considered a low risk to crew health and safety. Excellent agreement between inflight and archival sample TOC data confirmed that the TOCA performed optimally and it continued to serve as a vital tool for monitoring organic breakthrough and planning remediation action.

2014 ISS Potable Water Characterization and Continuation of the Dimethylsilanediol Chronicle

NASA Technical Reports Server (NTRS)

Straub, John E., II; Plumlee, Debrah K.; Mudgett, Paul D.

2015-01-01

During 2014 the crews from Expeditions 38-41 were in residence on the International Space Station (ISS). In addition to the U.S. potable water reclaimed from humidity condensate and urine, the other water supplies available for their use were Russian potable water reclaimed from condensate and Russian ground-supplied potable water. Beginning in June of 2014 and for the fourth time since 2010, the product water from the U.S. water processor assembly (WPA) experienced a rise in the total organic carbon (TOC) level due to organic contaminants breaking through the water treatment process. Results from ground analyses of ISS archival water samples returned on Soyuz 38 confirmed that dimethylsilanediol was once again the contaminant responsible for the rise. With this confirmation in hand and based upon the low toxicity of dimethylsilanediol, a waiver was approved to allow the crew to continue to consume the water after the TOC level exceeded the U.S. Segment limit of 3 mg/L. Several weeks after the WPA multifiltration beds were replaced, the TOC levels returned to below the method detection limit of the onboard TOC analyzer (TOCA) as anticipated based upon experience from previous rises. This paper presents and discusses the chemical analysis results for the ISS archival potable-water samples returned in 2014 and analyzed by the Johnson Space Center's Toxicology and Environmental Chemistry laboratory. These results showed compliance with ISS potable water quality standards and indicated that the potable-water supplies were acceptable for crew consumption. Although dimethylsilanediol levels were at times elevated, they remained well below the 35 mg/L health limit so the continued consumption of the U.S. potable water was considered a low risk to crew health and safety. Excellent agreement between in-flight and archival sample TOC data confirmed that the TOCA performed optimally and continued to serve as a vital tool for monitoring organic breakthrough and planning remediation action.

Modeling Geometric Arrangements of TiO2-Based Catalyst Substrates and Isotropic Light Sources to Enhance the Efficiency of a Photocatalystic Oxidation (PCO) Reactor

NASA Technical Reports Server (NTRS)

Richards, Jeffrey T.; Levine, Lanfang H.; Husk, Geoffrey K.

2011-01-01

The closed confined environments of the ISS, as well as in future spacecraft for exploration beyond LEO, provide many challenges to crew health. One such challenge is the availability of a robust, energy efficient, and re-generable air revitalization system that controls trace volatile organic contaminants (VOCs) to levels below a specified spacecraft maximum allowable concentration (SMAC). Photocatalytic oxidation (PCO), which is capable of mineralizing VOCs at room temperature and of accommodating a high volumetric flow, is being evaluated as an alternative trace contaminant control technology. In an architecture of a combined air and water management system, placing a PCO unit before a condensing heat exchanger for humidity control will greatly reduce the organic load into the humidity condensate loop ofthe water processing assembly (WPA) thereby enhancing the life cycle economics ofthe WPA. This targeted application dictates a single pass efficiency of greater than 90% for polar VOCs. Although this target was met in laboratory bench-scaled reactors, no commercial or SBIR-developed prototype PCO units examined to date have achieved this goal. Furthermore, the formation of partial oxidation products (e.g., acetaldehyde) was not eliminated. It is known that single pass efficiency and partial oxidation are strongly dependent upon the contact time and catalyst illumination, hence the requirement for an efficient reactor design. The objective of this study is to maximize the apparent contact time and illuminated catalyst surface area at a given reactor volume and volumetric flow. In this study, a Ti02-based photocatalyst is assumed to be immobilized on porous substrate panels and illumination derived from linear isotropic light sources. Mathematical modeling using computational fluid dynamics (CFD) analyses were performed to investigate the effect of: 1) the geometry and configuration of catalyst-coated substrate panels, 2) porosity of the supporting substrate, and 3) varying the light source and spacing on contact time and illuminated catalyst area.

Upgrades to the ISS Water Recovery System

NASA Technical Reports Server (NTRS)

Pruitt, Jennifer M.; Carter, Layne; Bagdigian, Robert M.; Kayatin, Mattthew J.

2015-01-01

The ISS Water Recovery System (WRS) includes the Water Processor Assembly (WPA) and the Urine Processor Assembly (UPA). The WRS produces potable water from a combination of crew urine (first processed through the UPA), crew latent, and Sabatier product water. The WRS has been operational on ISS since November 2008, producing over 21,000 L of potable water during that time. Though the WRS has performed well during this time, several modifications have been identified to improve the overall system performance. These modifications can reduce resupply and improve overall system reliability, which is beneficial for the ongoing ISS mission as well as for future NASA manned missions. The following paper lists these modifications, how they improve WRS performance, and a status on the ongoing development effort.

Standards of care for obsessive–compulsive disorder centres

PubMed Central

Menchón, José M.; van Ameringen, Michael; Dell’Osso, Bernardo; Denys, Damiaan; Figee, Martijn; Grant, Jon E.; Hollander, Eric; Marazziti, Donatella; Nicolini, Humberto; Pallanti, Stefano; Ruck, Christian; Shavitt, Roseli; Stein, Dan J.; Andersson, Erik; Bipeta, Rajshekhar; Cath, Danielle C.; Drummond, Lynne; Feusner, Jamie; Geller, Daniel A.; Hranov, Georgi; Lochner, Christine; Matsunaga, Hisato; McCabe, Randy E.; Mpavaenda, Davis; Nakamae, Takashi; O'Kearney, Richard; Pasquini, Massimo; Pérez Rivera, Ricardo; Poyurovsky, Michael; Real, Eva; do Rosário, Maria Conceição; Soreni, Noam; Swinson, Richard P.; Vulink, Nienke; Zohar, Joseph; Fineberg, Naomi

2016-01-01

Abstract In recent years, many assessment and care units for obsessive–compulsive disorder (OCD) have been set up in order to detect, diagnose and to properly manage this complex disorder, but there is no consensus regarding the key functions that these units should perform. The International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) together with the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP) and the Anxiety and Obsessive Compulsive Disorders Section of the World Psychiaric Association (WPA) has developed a standards of care programme for OCD centres. The goals of this collaborative initiative are promoting basic standards, improving the quality of clinical care and enhance the validity and reliability of research results provided by different facilities and countries. PMID:27359333

28 CFR 524.42 - Content of progress reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Content of progress reports. 524.42 Section 524.42 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INMATE ADMISSION... inmate's: (1) Program plans; (2) Work assignments and skills acquired; (3) Educational/vocational...

Response: Progress Takes Time.

ERIC Educational Resources Information Center

Rist, Marilee C.

1984-01-01

Although declining enrollment and administrative seniority have hampered efforts to eliminate sex discrimination in employment practices in three Long Island, New York, school systems (Commack, Smithtown, and Bay Shore), progress is being made. Because of the Reagan administration's lack of support for affirmative action, however, litigation…

The Infusion of Corporate Values into Progressive Education: Professional Vulnerability or Complicity?

ERIC Educational Resources Information Center

Gamson, David A.

2004-01-01

Examines the history of educational administration in the USA during the Progressive era (1890-1940). Using Callahan's Education and the Cult of Efficiency as a starting point, examines school district-based administrative practices that offered viable alternatives to the business-oriented, "scientific management" reforms that tended to…

Global modelling of Cryptosporidium in surface water

NASA Astrophysics Data System (ADS)

Vermeulen, Lucie; Hofstra, Nynke

2016-04-01

Introduction Waterborne pathogens that cause diarrhoea, such as Cryptosporidium, pose a health risk all over the world. In many regions quantitative information on pathogens in surface water is unavailable. Our main objective is to model Cryptosporidium concentrations in surface waters worldwide. We present the GloWPa-Crypto model and use the model in a scenario analysis. A first exploration of global Cryptosporidium emissions to surface waters has been published by Hofstra et al. (2013). Further work has focused on modelling emissions of Cryptosporidium and Rotavirus to surface waters from human sources (Vermeulen et al 2015, Kiulia et al 2015). A global waterborne pathogen model can provide valuable insights by (1) providing quantitative information on pathogen levels in data-sparse regions, (2) identifying pathogen hotspots, (3) enabling future projections under global change scenarios and (4) supporting decision making. Material and Methods GloWPa-Crypto runs on a monthly time step and represents conditions for approximately the year 2010. The spatial resolution is a 0.5 x 0.5 degree latitude x longitude grid for the world. We use livestock maps (http://livestock.geo-wiki.org/) combined with literature estimates to calculate spatially explicit livestock Cryptosporidium emissions. For human Cryptosporidium emissions, we use UN population estimates, the WHO/UNICEF JMP sanitation country data and literature estimates of wastewater treatment. We combine our emissions model with a river routing model and data from the VIC hydrological model (http://vic.readthedocs.org/en/master/) to calculate concentrations in surface water. Cryptosporidium survival during transport depends on UV radiation and water temperature. We explore pathogen emissions and concentrations in 2050 with the new Shared Socio-economic Pathways (SSPs) 1 and 3. These scenarios describe plausible future trends in demographics, economic development and the degree of global integration. Results and Conclusions GloWPa-Crypto is the first global model that can be used to analyse dynamics in surface water pathogen concentrations worldwide. Global human Cryptosporidium emissions are estimated at 1 x 10^17 oocysts/ year for the year 2010.We estimated future emissions for SSP1 and SSP3. Preliminary results show that for SSP1human emissions are approximately halved by 2050. The SSP3 human emissions are 1.5 times higher than the 2010 emissions due to increased population growth and urbanisation. Livestock Cryptosporidium emissions are expected to increase under both SSP1 and SSP3, as meat consumption continues to rise. We conclude that population growth, urbanization, changes in sanitation systems and treatment, and changes in livestock consumption and production systems are important processes that determine future Cryptosporidium emissions to surface water. References Hofstra N, Bouwman A F, Beusen A H W and Medema G J 2013 Exploring global Cryptosporidium emissions to surface water Sci. Total Environ. 442 10-9 Kiulia N M, Hofstra N, Vermeulen L C, Obara M A, Medema G J and Rose J B 2015 Global occurrence and emission of rotaviruses to surface waters Pathogens 4 229-55 Vermeulen L C, De Kraker J, Hofstra N, Kroeze C and Medema G J 2015 Modelling the impact of sanitation, population and urbanization estimates on human emissions of Cryptosporidium to surface waters - a case study for Bangladesh and India Environ. Res. Lett. 10

Post-Flight Microbial Analysis of Samples from the International Space Station Water Recovery System and Oxygen Generation System

NASA Technical Reports Server (NTRS)

Birmele, Michele N.

2011-01-01

The Regenerative, Environmental Control and Life Support System (ECLSS) on the International Space Station (ISS) includes the the Water Recovery System (WRS) and the Oxygen Generation System (OGS). The WRS consists of a Urine Processor Assembly (UPA) and Water Processor Assembly (WPA). This report describes microbial characterization of wastewater and surface samples collected from the WRS and OGS subsystems, returned to KSC, JSC, and MSFC on consecutive shuttle flights (STS-129 and STS-130) in 2009-10. STS-129 returned two filters that contained fluid samples from the WPA Waste Tank Orbital Recovery Unit (ORU), one from the waste tank and the other from the ISS humidity condensate. Direct count by microscopic enumeration revealed 8.38 x 104 cells per mL in the humidity condensate sample, but none of those cells were recoverable on solid agar media. In contrast, 3.32 x lOs cells per mL were measured from a surface swab of the WRS waste tank, including viable bacteria and fungi recovered after S12 days of incubation on solid agar media. Based on rDNA sequencing and phenotypic characterization, a fungus recovered from the filter was determined to be Lecythophora mutabilis. The bacterial isolate was identified by rDNA sequence data to be Methylobacterium radiotolerans. Additional UPA subsystem samples were returned on STS-130 for analysis. Both liquid and solid samples were collected from the Russian urine container (EDV), Distillation Assembly (DA) and Recycle Filter Tank Assembly (RFTA) for post-flight analysis. The bacterium Pseudomonas aeruginosa and fungus Chaetomium brasiliense were isolated from the EDV samples. No viable bacteria or fungi were recovered from RFTA brine samples (N= 6), but multiple samples (N = 11) from the DA and RFTA were found to contain fungal and bacterial cells. Many recovered cells have been identified to genus by rDNA sequencing and carbon source utilization profiling (BiOLOG Gen III). The presence of viable bacteria and fungi from WRS and OGS subsystems demonstrates the need for continued monitoring of ECLSS during future ISS operations and investigation of advanced antimicrobial controls.

Leisure-time physical activity and other factors in relation to blood pressure in Japanese-Americans in Hawaii, USA.

PubMed

Liu, L; Kanda, T; Sagara, M; Hirao, S; Yasui, N; Negishi, H; Sekine, Y; Honda, K; Ikeda, K; Yamori, Y

2001-03-01

To examine physical activity at work and during leisure-time as well as other factors related to blood pressure (BP) in Japanese-Americans living in Hilo, Hawaii, USA, we performed a population-based cross-sectional study with a sample of 238 participants aged 42-64 years old. This survey was carried out between 19 February and 1 March 2000 in Hilo. All participants were invited to Hilo Medical Center for a free physical examination and experimental tests including an examination of blood and urine samples. A self-administered health questionnaire was used that included items related to demographics, smoking, alcohol consumption, and habitual physical activity at work and during leisure-time. A summary score of physical activity (PA) was calculated. BP was measured using an automated BP measurement system (Khi machine, VINE Co., Ltd., Kyoto, Japan). The results showed the following. 1) Mean (SD) PA scores at work (WPA) and during leisure-time (LTPA) were 2.9 (0.5) and 2.5 (0.5) in men, and 3.0 (0.5) and 2.4 (0.3) in women, respectively; 2) Pearson correlation analyses (adjustment for age) indicated that WPA and LTPA in men show significant negative associations with SBP and DBP (p<0.05 and p<0.01), while LTPA shows significant negative associations with SBP and DBP in women (p<0.05 and p<0.01). After further adjustment for education, occupation, smoking, and alcohol consumption status, LTPA continued to show significant and negative associations with both SBP and DBP in men (p<0.01) and with DBP alone in women (p <0.01). 3) Hypertensive subjects had significantly lower mean LTPA scores than normotensive men (2.39 vs. 2.61, p<0.05) and women (2.32 vs. 2.45, p<0.05). 4) Body mass index and the ratio of sodium to potassium excretion showed significant and positive associations with SBP and DBP in multiple linear regression analyses. In conclusion, the results further emphasize that the health benefits of LTPA, control of body weight, and reduction in salt intake should continually receive strong attention in population-based high BP control.

Hayabusa Reentry and Recovery of Its Capsule -Quick Report

NASA Astrophysics Data System (ADS)

Kawaguchi, Junichiro; Yoshikawa, Makoto; Kuninaka, Hitoshi

The Hayabusa spacecraft successfully returned to the Earth and re-entered into the atmosphere for sample recovery after also the successful touching-downs to NEO Itokawa in 2005. The reentry occurred on June 13th, and took place in Woomera Prohibited Area (WPA) of Australia. This paper presents how the reentry and recovery operations were performed, and also reports the current status about the sample curation activity. The Hayabusa mission aims at demonstrating key technologies requisite for future real Sample and Return missions. However, the spacecraft adopted the actual Sample and Return flight sequence and was designed to make a world's first round trip to an extra terrestrial object with touching-down and lifting-off. It is the spacecraft propelled by the ion engines aboard for interplanetary cruise. The Hayabusa spacecraft launched in May of 2003 reached NEO Itokawa in September of 2005 via Earth gravity assist in May of 2004. It stayed there for about two and a half months, and performed detailed scientific observation and mapping and determination of the shape. In November of 2005, the spacecraft made two touching-downs and lifting-offs having attempted collection of surface sample. At the second opportunity, the spacecraft directed shooting a projectile. But, due to the programming problem, presumably the projectile was not shot. However, the spacecraft may have captured some small amount of sample particles in a catcher aboard, when the spacecraft made actual touches down to the surface. The spacecraft suffered from fuel leak in December of 2005, and the communication resumed after seven weeks of hiatus. And the ion engines all faced their life by November of 2009, and the project team devised an alternative drive configuration and successfully coped with the difficulty. Despite many hardships, the spacecraft has been operated for return cruise, and it made a reentry for sample recovery this June. The sample catcher was retrieved at WPA and transported back to the curation facility of JAXA. Currently the curators have examined analyzed the catcher recovered. This presentation quickly reports recent status of the spacecraft, capsule and sample analysis.

Dynamic uptake of radioactive substance in rat salivary gland following /sup 3/H-melatonin administration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Withyachumnarnkul, B.; Wongprapairot, P.; Trakulrungsi, W.

Dynamics of radioactive accumulation in rat greater salivary gland following systemic administration of /sup 3/H-melatonin was studied to determine a possible action of the hormone in the gland. Progressive decline of /sup 3/H-melatonin concentrations was found in the serum, lung, skeletal muscle, liver, kidney, and salivary gland during 60 min following the administration. On the contrary, there was a progressive accumulation of radioactive substance other than /sup 3/H-melatonin in the salivary gland but not in other tissues mentioned. The radioactivity was also progressively and preferentially localized in the nuclear fraction of the gland cells. These results suggest a possible directmore » action of melatonin derivative in rat salivary gland.« less

Predicting reading outcomes with progress monitoring slopes among middle grade students

PubMed Central

Tolar, Tammy D.; Barth, Amy E.; Fletcher, Jack M.; Francis, David J.; Vaughn, Sharon

2013-01-01

Effective implementation of response-to-intervention (RTI) frameworks depends on efficient tools for monitoring progress. Evaluations of growth (i.e., slope) may be less efficient than evaluations of status at a single time point, especially if slopes do not add to predictions of outcomes over status. We examined progress monitoring slope validity for predicting reading outcomes among middle school students by evaluating latent growth models for different progress monitoring measure-outcome combinations. We used multi-group modeling to evaluate the effects of reading ability, reading intervention, and progress monitoring administration condition on slope validity. Slope validity was greatest when progress monitoring was aligned with the outcome (i.e., word reading fluency slope was used to predict fluency outcomes in contrast to comprehension outcomes), but effects varied across administration conditions (viz., repeated reading of familiar vs. novel passages). Unless the progress monitoring measure is highly aligned with outcome, slope may be an inefficient method for evaluating progress in an RTI context. PMID:24659899

Development Status of the International Space Station Urine Processor Assembly

NASA Technical Reports Server (NTRS)

Holder, Donald W.; Hutchens, Cindy F.

2003-01-01

NASA, Marshall Space Flight Center (MSFC) is developing a Urine Processor Assembly (UPA) for the International Space Station (ISS). The UPA uses Vapor Compression Distillation (VCD) technology to reclaim water from pre-treated urine. This water is further processed by the Water Processor Assembly (WPA) to potable quality standards for use on the ISS. NASA has developed this technology over the last 25-30 years. Over this history, many technical issues were solved with thousands of hours of ground testing that demonstrate the ability of the UPA technology to reclaim water from urine. In recent years, NASA MSFC has been responsible for taking the UPA technology to "flight design" maturity. This paper will give a brief overview of the UPA design and a status of the major design and development efforts completed recently to mature the UPA to a flight level.

WPA guidance on mental health and mental health care in migrants

PubMed Central

BHUGRA, DINESH; GUPTA, SUSHAM; BHUI, KAMALDEEP; CRAIG, TOM; DOGRA, NISHA; INGLEBY, J. DAVID; KIRKBRIDE, JAMES; MOUSSAOUI, DRISS; NAZROO, JAMES; QURESHI, ADIL; STOMPE, THOMAS; TRIBE, RACHEL

2011-01-01

The purpose of this guidance is to review currently available evidence on mental health problems in migrants and to present advice to clinicians and policy makers on how to provide migrants with appropriate and accessible mental health services. The three phases of the process of migration and the relevant implications for mental health are outlined, as well as the specific problems of groups such as women, children and adolescents, the elderly, refugees and asylum seekers, and lesbian, gay, bisexual and transgender individuals. The concepts of cultural bereavement, cultural identity and cultural congruity are discussed. The epidemiology of mental disorders in migrants is described. A series of recommendations to policy makers, service providers and clinicians aimed to improve mental health care in migrants are provided, covering the special needs of migrants concerning pharmacotherapies and psychotherapies. PMID:21379345

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

76 FR 81942 - Federal Acquisition Regulation; Information Collection; Progress Payments (SF-1443)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

...; Information Collection; Progress Payments (SF-1443) AGENCIES: Department of Defense (DOD), General Services... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE... requirement concerning progress payments. Public comments are particularly invited on: Whether this collection...

Exercise Administrator Administrative Instructions for Age Classes 1, 2 & 3. Year 11, October 1979-May 1980.

ERIC Educational Resources Information Center

Research Triangle Inst., Durham, NC.

This manual for Exercise Administrators of the National Assessment of Educational Progress; Second Literature Third Reading Assessment, consists of administrative instructions for use immediately preceding, during and after assessment sessions in schools. Definitions of racial/ethnic categories, associated codes, and guidelines for solicting…

Equitunity in Vocational Education Administration: A Handbook for Women.

ERIC Educational Resources Information Center

Parker, James C.; And Others

This handbook is designed to assist women in and aspiring to vocational education administration in planning for entry into and success in vocational education administration. It consists of five sections. Section 1 describes the following barriers inhibiting the progress of women in administration: self-concept, career choice, career preparation,…

77 FR 19287 - Federal Acquisition Regulation; Submission for OMB Review; Progress Payments (SF-1443)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

...; Submission for OMB Review; Progress Payments (SF-1443) AGENCY: Department of Defense (DOD), General Services... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE... requirement concerning progress payments. A notice was published in [[Page 19288

The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study.

PubMed

Bousquet, J; Arnavielhe, S; Bedbrook, A; Fonseca, J; Morais Almeida, M; Todo Bom, A; Annesi-Maesano, I; Caimmi, D; Demoly, P; Devillier, P; Siroux, V; Menditto, E; Passalacqua, G; Stellato, C; Ventura, M T; Cruz, A A; Sarquis Serpa, F; da Silva, J; Larenas-Linnemann, D; Rodriguez Gonzalez, M; Burguete Cabañas, M T; Bergmann, K C; Keil, T; Klimek, L; Mösges, R; Shamai, S; Zuberbier, T; Bewick, M; Price, D; Ryan, D; Sheikh, A; Anto, J M; Mullol, J; Valero, A; Haahtela, T; Valovirta, E; Fokkens, W J; Kuna, P; Samolinski, B; Bindslev-Jensen, C; Eller, E; Bosnic-Anticevich, S; O'Hehir, R E; Tomazic, P V; Yorgancioglu, A; Gemicioglu, B; Bachert, C; Hellings, P W; Kull, I; Melén, E; Wickman, M; van Eerd, M; De Vries, G

2018-02-01

Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Users with a score of 3 or 4 had a significant impairment in quality-of-life questionnaires. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Knowledge Transfer and Teaching Public Administration: The Academy Model

ERIC Educational Resources Information Center

Hall, Michael

2015-01-01

Since the beginnings of Public Administration in the US and its accompanying education in other parts of the world, government and policy have become more complex. The education in Public Administration created a professional pathway to public service. The addition of education to Public Administration came out of the Progressive Movement in the…

40 CFR 60.2595 - What if I do not meet an increment of progress?

Code of Federal Regulations, 2010 CFR

2010-07-01

... or Before November 30, 1999 Model Rule-Increments of Progress § 60.2595 What if I do not meet an... Administrator postmarked within 10 business days after the date for that increment of progress in table 1 of...

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot and Deputy Associate Administrator Lesa Roe speak to employees during a town hall meeting in the conference room of Operations Support Building II. During the gathering, they updated progress on NASA programs.

Administration of Progress Payments at Defense Contract Management District-West

DTIC Science & Technology

1993-08-05

the progress payment is calculated from the contractor’s incurred cost, the actual amount payable is always limited by the fair value of the...progress payments exceed the fair value of undelivered work. In addition to assessing the validity of the EAC relative to the progress payment request...were overpaid because Air Force Plant Representative Offices incorrectly calculated progress payment reductions for fair value of remaining work

Administrative Problems of Early Immersion.

ERIC Educational Resources Information Center

McGillivray, W. R.

1978-01-01

Administrative problems that have been solved or accepted during eight years of early immersion programs are discussed including choosing locations, staffing, costs, logistics, and the need for suitable pupil progress reporting. (JMF)

PDP-11 Meeting School District Administrative Data Processing Challenges.

ERIC Educational Resources Information Center

Technological Horizons in Education, 1983

1983-01-01

Elmhurst Community Unit School District 205 (Illinois) is currently using a Digital PDP-11/70 computer system and administrative software to handle administrative functions with ease and efficiency. These functions include production of reports and payroll, student scheduling, reporting grades and student progress, and maintaining student…

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot speaks to employees during a town hall meeting in the conference room of Operations Support Building II. To the right is Deputy Associate Administrator Lesa Roe. During the gathering, they updated progress on NASA programs.

20 CFR 411.180 - What is timely progress toward self-supporting employment?

Code of Federal Regulations, 2014 CFR

2014-04-01

...-supporting employment? 411.180 Section 411.180 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET... dependence on Social Security disability benefits or SSI benefits. We will also consider you to be making... study), we will consider you to have met the timely progress requirements for purposes of the progress...

20 CFR 411.180 - What is timely progress toward self-supporting employment?

Code of Federal Regulations, 2012 CFR

2012-04-01

...-supporting employment? 411.180 Section 411.180 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET... dependence on Social Security disability benefits or SSI benefits. We will also consider you to be making... study), we will consider you to have met the timely progress requirements for purposes of the progress...

DRDE-07 and its analogues as promising cytoprotectants to nitrogen mustard (HN-2)--an alkylating anticancer and chemical warfare agent.

PubMed

Sharma, Manoj; Vijayaraghavan, R; Gautam, Anshoo

2009-08-10

Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg/kg) percutaneously, decreased WBC count from 24h onwards. Liver glutathione (GSH) level decreased prominently and the maximum depletion was observed on 7th day post-HN-2 administration. Oxidised glutathione (GSSG) level increased significantly at 24h post-administration and subsequently showed a progressive decrease. Hepatic malondialdehyde (MDA) level and percent DNA damage increased progressively following HN-2 administration. The spleen weight decreased progressively and reached a minimum on 3-4 days with subsequent increase. The antidotes were administered repeatedly for 4 and 8 days after percutaneous administration of single sublethal dose (0.5 and 0.25 LD(50)) of HN-2. Treatment with DRDE-07, DRDE-30 and DRDE-35 significantly protected the changes in spleen weight, WBC count, GSH, GSSG, MDA and DNA damage following HN-2 administration (0.5 and 0.25 LD(50)). There was no alteration in the transaminases (AST and ALT), and alkaline phosphatase (ALP) activities, neither with HN-2 nor with antidotes. The present study shows that HN-2 is highly toxic by percutaneous route and DRDE-07, DRDE-30 and DRDE-35 can partially protect it.

40 CFR 60.1605 - What if I do not meet an increment of progress?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Times for Small Municipal Waste Combustion Units Constructed on or Before August 30, 1999 Model Rule... increment of progress, you must submit a notification to the Administrator postmarked within 10 business...

48 CFR 32.503-5 - Administration of progress payments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... considered desirable by the ACO to determine the validity of progress payments already made and expected to... resources to complete the contract; and (4) There is reason to doubt the adequacy and reliability of the...

Status of States' Progress in Implementing Part H of IDEA: Report #3.

ERIC Educational Resources Information Center

Harbin, Gloria L.; And Others

This report focuses on progress in the implementation of Part H of the Individuals with Disabilities Education Act (IDEA) through a comparison of states' status on three yearly administrations of the State Progress Scale. The scale was designed to monitor implementation of the required 14 components in the stages of policy development, policy…

20 CFR 411.200 - How will the PM conduct my progress reviews?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How will the PM conduct my progress reviews? 411.200 Section 411.200 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF... in § 411.180 in the applicable progress certification period, the PM will find that you are making...

Completing the One EPA Web Transformation (Email Message)

EPA Pesticide Factsheets

Deputy administrator Stan Meiburg urged other administrators to review their web transformation progress, and make sure they have requested extensions and planned to temporarily transfer content to the www3 server, before the September 30, 2015 deadline.

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 742.1170-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance monitoring is a function of contract administration used to determine contractor progress towards achieving...

Gorham's disease of the proximal tibia successfully treated with local administration of OK-432, followed by reconstruction with distraction osteogenesis: a case report.

PubMed

Yamagishi, Eiki; Takeda, Akira; Konno, Shinichi; Takeda, Koichiro; Hagino, Seita; Hakozaki, Michiyuki

2016-01-01

Gorham's disease (GD) is a rare and intractable disease characterized by marked progression of osteolysis associated with lymphangioma and/or hemangioma. Here, we describe a case of GD of the proximal tibia occurring in a 10-year-old boy. Although we could not correctly diagnose it at first, we finally diagnosed him as having GD. Progression of osteolysis of the tibia stopped 3 months after the local administration of OK-432. Thereafter, the huge bone defect with varus and extension deformity was reconstructed successfully by distraction osteogenesis using the Ilizarov method. The present case suggests that local administration of OK-432, followed by distraction osteogenesis is a treatment option for GD.

A Study of Difficulties and Approaches for Innovative Talents Training of Public Administration Undergraduates

ERIC Educational Resources Information Center

Zhu, Yanhan; Wu, Juan

2014-01-01

The innovation is the soul of one nation making progresses. To build an innovative country, we need to train more innovative talents who is capable of public administration. The innovative talents training of public administration undergraduate faces a lot of problems, such as the influences of traditional culture, the constraint of education…

The Practice-Research Relationship in Educational Administration: Potion or Poison?

ERIC Educational Resources Information Center

Lutz, Frank W.

1979-01-01

Written in response to a paper by Wayne K. Hoy on theory and practice in educational administration, this paper maintains that research and practice must be coordinated if educational administration is to progress. The author outlines Hoy's key points, agreeing with many but taking issue with Hoy's central thesis, which the author perceives as…

40 CFR 60.5235 - What reports must I submit?

Code of Federal Regulations, 2014 CFR

2014-07-01

.... (3) If you fail to meet an increment of progress, you must submit a notification to the Administrator... Administrator every 4 weeks that includes the three items in paragraphs (e)(1)(ii)(A) through (e)(1)(ii)(C) of... from the Administrator to continue operation of the SSI unit. (2) If your unit was shut down by the...

40 CFR 60.5235 - What reports must I submit?

Code of Federal Regulations, 2011 CFR

2011-07-01

.... (3) If you fail to meet an increment of progress, you must submit a notification to the Administrator... Administrator every 4 weeks that includes the three items in paragraphs (e)(1)(ii)(A) through (e)(1)(ii)(C) of... from the Administrator to continue operation of the SSI unit. (2) If your unit was shut down by the...

40 CFR 60.5235 - What reports must I submit?

Code of Federal Regulations, 2012 CFR

2012-07-01

.... (3) If you fail to meet an increment of progress, you must submit a notification to the Administrator... Administrator every 4 weeks that includes the three items in paragraphs (e)(1)(ii)(A) through (e)(1)(ii)(C) of... from the Administrator to continue operation of the SSI unit. (2) If your unit was shut down by the...

48 CFR 4.803 - Contents of contract files.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Cost or price analysis. (20) Audit reports or reasons for waiver. (21) Record of negotiation. (22... them. (13) Documents supporting advance or progress payments. (14) Progressing, expediting, and production surveillance records. (15) Quality assurance records. (16) Property administration records. (17...

48 CFR 742.1170 - Performance monitoring and progress reporting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Performance monitoring and progress reporting. 742.1170 Section 742.1170 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting...

48 CFR 742.1170 - Performance monitoring and progress reporting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance monitoring and progress reporting. 742.1170 Section 742.1170 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting...

Tracking initially unresolved thrusting objects in 3D using a single stationary optical sensor

NASA Astrophysics Data System (ADS)

Lu, Qin; Bar-Shalom, Yaakov; Willett, Peter; Granström, Karl; Ben-Dov, R.; Milgrom, B.

2017-05-01

This paper considers the problem of estimating the 3D states of a salvo of thrusting/ballistic endo-atmospheric objects using 2D Cartesian measurements from the focal plane array (FPA) of a single fixed optical sensor. Since the initial separations in the FPA are smaller than the resolution of the sensor, this results in merged measurements in the FPA, compounding the usual false-alarm and missed-detection uncertainty. We present a two-step methodology. First, we assume a Wiener process acceleration (WPA) model for the motion of the images of the projectiles in the optical sensor's FPA. We model the merged measurements with increased variance, and thence employ a multi-Bernoulli (MB) filter using the 2D measurements in the FPA. Second, using the set of associated measurements for each confirmed MB track, we formulate a parameter estimation problem, whose maximum likelihood estimate can be obtained via numerical search and can be used for impact point prediction. Simulation results illustrate the performance of the proposed method.

Schools as Ecosystems

ERIC Educational Resources Information Center

Seydel, Jennifer

2011-01-01

Creating green schools often hinges on administrators. Principals, superintendents, and other school leaders have the authority and skill sets to make important, even if incremental, progress toward creating green learning environments. This article provides background and reference information that will help administrators with their initial…

Proceedings of the Federal Transit Administration's Urban Maglev Workshop

DOT National Transportation Integrated Search

2005-09-01

The Federal Transit Administrations (FTA) Urban Maglev Workshop was held at FTA Headquarters in Washington, DC, on September 8-9, 2005. The key workshop goals were to review progress, share lessons learned among the grantees, and discuss future di...

Effect of separate and combined exposure of selenium and diazinon on rat sperm motility by computer assisted semen analysis.

PubMed

Toman, Robert; Hluchy, Svatoslav; Cabaj, Michal; Massanyi, Peter; Roychoudhury, Shubhadeep; Tunegova, Martina

2016-12-01

Effects of selenium (Se) and diazinon (DZN) on sperm motility parameters in rats were investigated. Male rats received a separate dose of Se (2mgkg -1 b.w., intraperitoneally, 5mgL -1 , per os in drinking water), diazinon (20mgkg -1 b.w., intraperitoneally, 40mgL -1 , per os in drinking water), and in combination (Se+DZN) with the same dosage as in the separate administration. 36h an intraperitoneal (i.p.) and after 90days of per oral (p.o.) exposure, thirteen parameters of sperm motility were evaluated using a Computer Assisted Sperm Analyzer (CASA). Almost all the evaluated sperm motility parameters significantly decreased in Se p.o. exposed groups. In the Se i.p. group decrease was noted only in beat cross frequency (BCF) and progressive motility. Significant decline in the sperm motility, progressive motility, BCF and increase in amplitude of lateral head displacement (ALH) were recorded after DZN i.p. administration. In DZN p.o. group, significant increase in ALH, velocity average path (VAP) and curvilinear velocity (VCL) but decrease in progressive motility and BCF was detected. Se+DZN i.p. administration caused a significant decrease in motility, progressive motility and BCF. Per oral administration of Se+DZN decreased all motility parameters except LIN, WOB and ALH. Sperm abnormalities increased in all experimental conditions. Se and DZN negatively affected sperm structure and function in separate doses or in combination. No protective effect of Se was observed. Copyright © 2016 Elsevier GmbH. All rights reserved.

Planning and environment linkages program : a guide to measuring progress in linking transportation planning and environmental analysis

DOT National Transportation Integrated Search

2009-12-01

Transportation agencies use a variety of metrics to document progress toward achieving specific goals and objectives. This guide, developed by Federal Highway Administration (FHWA) Planning and Environmental Linkages (PEL) program, is intended to hel...

48 CFR 742.1170-4 - Progress reporting requirements and contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirements and contract clause. 742.1170-4 Section 742.1170-4 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-4 Progress reporting requirements and contract clause. (a) When the requiring...

29 CFR 1908.7 - Relationship to enforcement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... exemption program). (b) Effect upon scheduling. (1) An onsite consultative visit already in progress will.... The consultant and the employer shall notify the compliance officer of the visit in progress and...

29 CFR 1908.7 - Relationship to enforcement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... exemption program). (b) Effect upon scheduling. (1) An onsite consultative visit already in progress will.... The consultant and the employer shall notify the compliance officer of the visit in progress and...

29 CFR 1908.7 - Relationship to enforcement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... exemption program). (b) Effect upon scheduling. (1) An onsite consultative visit already in progress will.... The consultant and the employer shall notify the compliance officer of the visit in progress and...

29 CFR 1908.7 - Relationship to enforcement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... exemption program). (b) Effect upon scheduling. (1) An onsite consultative visit already in progress will.... The consultant and the employer shall notify the compliance officer of the visit in progress and...

29 CFR 1908.7 - Relationship to enforcement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... exemption program). (b) Effect upon scheduling. (1) An onsite consultative visit already in progress will.... The consultant and the employer shall notify the compliance officer of the visit in progress and...

Rising to the Top: Career Progression of Women Senior-Level Student Affairs Administrators

ERIC Educational Resources Information Center

Ford, Devan

2014-01-01

Women account for over half of the populations of enrolled students and employed staff and administrators in higher education. In student affairs, women current accounts for over 60% of employees at the entry and mid-levels of administration, but less than half of all senior-level executive positions are filled by women. Furthermore, the majority…

Progressive Care Nurses Improving Patient Safety by Limiting Interruptions During Medication Administration.

PubMed

Flynn, Fran; Evanish, Julie Q; Fernald, Josephine M; Hutchinson, Dawn E; Lefaiver, Cheryl

2016-08-01

Because of the high frequency of interruptions during medication administration, the effectiveness of strategies to limit interruptions during medication administration has been evaluated in numerous quality improvement initiatives in an effort to reduce medication administration errors. To evaluate the effectiveness of evidence-based strategies to limit interruptions during scheduled, peak medication administration times in 3 progressive cardiac care units (PCCUs). A secondary aim of the project was to evaluate the impact of limiting interruptions on medication errors. The percentages of interruptions and medication errors before and after implementation of evidence-based strategies to limit interruptions were measured by using direct observations of nurses on 2 PCCUs. Nurses in a third PCCU served as a comparison group. Interruptions (P < .001) and medication errors (P = .02) decreased significantly in 1 PCCU after implementation of evidence-based strategies to limit interruptions. Avoidable interruptions decreased 83% in PCCU1 and 53% in PCCU2 after implementation of the evidence-based strategies. Implementation of evidence-based strategies to limit interruptions in PCCUs decreases avoidable interruptions and promotes patient safety. ©2016 American Association of Critical-Care Nurses.

40 CFR 60.2835 - What if I do not meet an increment of progress?

Code of Federal Regulations, 2010 CFR

2010-07-01

... or Before November 30, 1999 Model Rule-Air Curtain Incinerators § 60.2835 What if I do not meet an... Administrator postmarked within 10 business days after the date for that increment of progress in table 1 of...

Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: results of a phase II single institution trial

PubMed Central

Martín-Martorell, P; Roselló, S; Rodríguez-Braun, E; Chirivella, I; Bosch, A; Cervantes, A

2008-01-01

This is a phase II institutional exploratory trial of biweekly irinotecan and cetuximab administration regimen in metastatic colorectal cancer patients progressing to at least one previous chemotherapy line. A total of 40 patients were treated between November 2005 and November 2007 with irinotecan 180 mg m−2 and cetuximab 500 mg m−2 q2w (every 2 weeks), in every 21-day cycles, until unacceptable toxicity or progressive disease. An overall response rate of 22.5% was obtained (two complete and seven partial responses). The disease control rate was 60%. The time to progression was 3.4 months and the overall survival was 8 months. The toxicity compared very favourably to weekly cetuximab combination schedules. Grade 3/4 adverse effects were observed in 12 patients. Overall, our results turn up very similar both in terms of toxicity and efficacy to those obtained by weekly and biweekly administration regimens. PMID:18665167

Federal transit administration : progress and challenges in implementing and evaluating the job access and reverse commute program.

DOT National Transportation Integrated Search

2010-05-01

Established in 1998, the Job Access and Reverse Commute Program (JARC)administered by the Federal Transit Administration (FTA)awards grants to states and localities to provide transportation to help low-income individuals access jobs. In 2005, ...

40 CFR 35.115 - Evaluation of performance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements for progress reporting under 40 CFR 31.40(b). (b) Elements of the evaluation process. The.... The recipient may request review of the Regional Administrator's decision under the dispute processes... Evaluation of performance. (a) Joint evaluation process. The applicant and the Regional Administrator will...

77 FR 64384 - Proposed Information Collection (Supplemental Information for Change of Program or Reenrollment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-19

... Progress) Activity: Comment Request AGENCY: Veterans Benefits Administration, Department of Veterans Affairs. ACTION: Notice. SUMMARY: The Veterans Benefits Administration (VBA), Department of [[Page 64385... claimant's eligibility for additional educational benefits for a change of program or reenrollment after...

Women of Color in Academic Administration: Trends, Progress, and Barriers.

ERIC Educational Resources Information Center

Wilson, Reginald

1989-01-01

Presents historical events, legal restrictions, and traditional customs as barriers that women of color have faced in pursuit of academic administrative positions. Discusses degree attainment and fields of study for different ethnic groups. Recent changes in affirmative action policy are discussed. (JS)

50 years of physical growth and impressive technological advances unmatched by health human resources reform and cultural change.

PubMed

Scott, Graham W S

2012-01-01

The year 1962 was pre-medicare. The public was concerned about access and individual affordability of care. Funding involved public or private responsibility and the role of government. Physicians, the most influential providers, were concerned that government funding would result in the loss of their independence and their becoming state employees. The retrospective analysis "Looking Back 50 Years in Hospital Administration" by Graham and Sibbald is arresting as it underlines just how much progress we have made in what could be termed "hardware" in support of healthcare policy and hospital administration. From this perspective, the progress has been eye opening, given the advent of universal healthcare, the advancement in our physical facilities, the development of high-quality diagnostic equipment, the explosion of new research centres and new and complex clinical procedures. The development of this hardware has given our providers better weapons and contributed to a remarkable improvement in life expectancy. But progress in health administration and policy management involves more than hardware. If the hardware constitutes the tools, then the "software" of the healthcare system involves the human resources and the culture change that must be positioned to make maximum use of the hardware. In 2062, looking back at the 2012 experience, the legacy test may be whether we dealt with health human resources and culture change at a rate that matched our progress in hardware.

Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans.

PubMed

Stoops, William W; Vansickel, Andrea R; Lile, Joshua A; Rush, Craig R

2007-05-01

Recent clinical research indicates that d-amphetamine is effective in treating cocaine and methamphetamine dependence. There is concern, however, with the use of d-amphetamine as a pharmacotherapy because acute administration of d-amphetamine decreases inhibition in cocaine-using individuals and may increase drug-taking behavior. The purpose of the present experiment was to determine whether acute d-amphetamine pretreatment would alter the reinforcing, subject-rated, and cardiovascular effects of d-amphetamine. To this end, 7 human volunteers first sampled doses of oral d-amphetamine (0, 8, and 16 mg). These doses engender moderate drug taking and were selected to avoid a ceiling or floor effect. Volunteers were then allowed to self-administer these sampled doses using a modified progressive-ratio procedure in two sessions in which they received pretreatment with either 0 or 15 mg oral d-amphetamine 2 h prior to completing the modified progressive-ratio procedure. d-Amphetamine produced prototypical stimulant-like effects (e.g., increased ratings of stimulated, elevated blood pressure) and maintained responding on the modified progressive-ratio schedule. Pretreatment with 15 mg oral d-amphetamine also produced prototypical stimulant-like effects, but failed to alter break points for d-amphetamine on the modified progressive-ratio procedure relative to placebo pretreatment. These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration.

Letter of Concern from EPA to Mr. Terry A. Yonkers, Assistant Administrator for Installations, Environment, and Logistics, USAF, Concerning Cleanup at Tyndall AFB, FL

EPA Pesticide Factsheets

Letter from EPA's Assistant Administrator for Enforcement and Compliance Assurance expresses concern over Tyndall Air Force Base's August 19, 2010, Memorandum on Environmental Restoration Program Progress at Tyndall AFB, FL.

Morale for Principals: Does Mentoring Make a Difference?

ERIC Educational Resources Information Center

Felicello, Stacia Patterson

2014-01-01

The current demands placed on administrators, specifically principals, have become progressively more complex due to litigation, pressure from parents, societal changes, internal workplace expectations, and more than ever, mandates levied from state and federal government. Support through mentorship may be one means to help administrators meet the…

Workforce Training and Economic Development Fund: 2015 Annual Progress Report

ERIC Educational Resources Information Center

Iowa Department of Education, 2015

2015-01-01

The Department of Education, Division of Community Colleges, will annually provide the State Board of Education with The Workforce Training and Economic Development (WTED) Fund Annual Progress Report. Administration and oversight responsibility for the fund was transferred from the Iowa Economic Development Authority to the Iowa Department of…

Integration of Culturally Relevant Pedagogy into the Science Learning Progression Framework

ERIC Educational Resources Information Center

Bernardo, Cyntra

2017-01-01

This study integrated elements of culturally relevant pedagogy into a science learning progression framework, with the goal of enhancing teachers' cultural knowledge and thereby creating better teaching practices in an urban public high school science classroom. The study was conducted using teachers, an administrator, a science coach, and…

Selected Progressive Competencies for Education of the Gifted.

ERIC Educational Resources Information Center

Daniels, Roberta R.; And Others

Progressive competencies were identified for gifted students in grades kindergarten through 12 as a result of a survey of over 600 administrators, classroom teachers, and teachers of the gifted. Competencies were identified for four levels of development in the following six specific skill areas: creativity, affective development, academic…

Minorities in Higher Education: A Pipeline Problem?

ERIC Educational Resources Information Center

Sethna, Beheruz N.

2011-01-01

This paper uses national data from the American Council on Education (ACE) to study the progress of different ethnic groups through the academic pipeline--stages studied include the Bachelor's, Master's, doctoral, levels, and then progress to the Assistant, Associate, and (full) Professor stages, to full-time administrators and finally to the CEO…

76 FR 79754 - Twelfth Meeting: RTCA Special Committee 220, Automatic Flight Guidance and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... technologies Administrative items (meeting schedule, location, and next meeting agenda) Any other business... 2 status--progress, issues and plan Review of WG 3 status--progress, issues and plans Review action.... Issued in Washington, DC, on December 15, 2011. Robert L. Bostiga, Manager, Business Operations Branch...

Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)

DTIC Science & Technology

2015-12-01

animals continued with cocaine self-administration for an additional 4 days. The animals then underwent six days of extinction training followed by cue... extinction conditions to identify the indirect effects of (+)- naltrexone administration on cocaine seeking. Animals administered (+)-naltrexone during...sterile water and implanted after the last day of self-administration on FR5 (one day prior to the start of the progressive ratio schedule). The animals

Critical Issues that Face Tertiary Education Institutions and Administration.

ERIC Educational Resources Information Center

Williams, Gareth

1983-01-01

Issues of the university's role in social and economic progress, educational demand, employment needs and patterns, changes in instructional methods, research, and managing change without growth are discussed. The need to extract long-term policy needs from the multiplicity of short-term administrative demands is examined. (MSE)

A New Look at Instructional Leadership

ERIC Educational Resources Information Center

Gray, David

2009-01-01

The No Child Left Behind Act of 2001 is the federal government's most recent effort to influence curriculum in America's classrooms. Its requirements for high-stakes testing and Adequate Yearly Progress have put pressure on teachers and administrators to improve student achievement. Principals whose administrative training was grounded in a…

78 FR 13348 - Science Board to the Food and Drug Administration Advisory Committee; Amendment of Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... for Devices and Radiological Health Research Review subcommittee and the Global Health subcommittee. Progress updates will be presented regarding the Global Health subcommittee and the recently established...

The Carter Administration and Hispanics: A Partnership to Progress.

ERIC Educational Resources Information Center

Pales, David J. R.; And Others

The report is a summary of the responses of 8 federal agencies and departments (the Small Business Administration; the Environmental Protection Agency; and the Departments of Labor; Justice; Housing and Urban Development; Health, Education, and Welfare; Commerce; and Energy) to the inquiries made by President Jimmy Carter regarding issues,…

A Bridge to One America: The Civil Rights Performance of the Clinton Administration.

ERIC Educational Resources Information Center

Kraus, Rebecca S.; Chambers, David R.

This report assesses the civil rights record of Bill Clinton's presidential administration, examining progress made in federal civil rights law enforcement and policy development. Four sections include: (1) "Introduction: The Clinton Presidency in Perspective" (the civil rights landscape and continuing relevance of the fight for civil…

Replacement-ready? Succession planning tops health care administrators' priorities.

PubMed

Husting, P M; Alderman, M

2001-09-01

Nurses' increasing age coupled with health care's rapidly changing environment moves succession planning, originally only a business sector tool, to a top administrative priority. Through active support of your facility's executive leadership and a clear linkage to long range organization objectives, you can implement this progressive procedure.

The Administration of Educational Development in Latin America.

ERIC Educational Resources Information Center

Olivera, Carlos E.

Based on the realization that 20 years of educational development efforts in Latin America have had little result, this author identified problems in educational administration at the national and regional levels that are largely responsible for the lack of progress. A number of structural and legal problems were identified, including the…

Chemical Technology Division: Progress report, January 1, 1987--June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-02-01

This progress report summarizes the research and development efforts conducted in the Chemical Technology Division (Chem Tech) during the period January 1, 1987, to June 30, 1988. The following major areas are covered: waste management and environmental programs, radiochemical and reactor engineering programs, basic science and technology, Nuclear Regulatory Commission programs, and administrative resources and facilities. The Administrative Summary, an appendix, presents a comprehensive listing of publications, oral presentations, awards and recognitions, and patents of Chem Tech staff members during this period. A staffing level and financial summary and lists of seminars and Chem Tech consultants for the period aremore » also included.« less

Development and operations of the astrophysics data system

NASA Technical Reports Server (NTRS)

Murray, S. S.

1996-01-01

Monthly progress reports are given for the period April 1994 through September 1994. Each month's progress includes a general summary and overviews of Administrative functions, Systems Engineering, User Committee, User Support, Test and QA, System Integration, Development, Operations, and Suppliers of Data. These overviews include user and query statistics for the month.

Military Career Paths. Career Progression Patterns for Selected Occupations from the Military Career Guide.

ERIC Educational Resources Information Center

Military Entrance Processing Command (DOD), North Chicago, IL.

This document was developed in response to requests from guidance professionals for information about career progression in the military. It presents descriptions of typical career development patterns over a 20-year period for 25 enlisted and 13 officer occupations. The enlisted occupations are: administrative support specialists, air crew…

Canadian Environmental Concerns: Winnipeg, Manitoba. Progress Report. Project Canada West.

ERIC Educational Resources Information Center

Western Curriculum Project on Canada Studies, Edmonton (Alberta).

Part I of this progress report places emphasis on curriculum development from the standpoint of the teacher-developer. The role is defined and factors such as teacher selection, release time, administrative cooperation, work schedules, assigned work space, and benefits to the school division and to the teacher are discussed. Recommendations deal…

Students' Knowledge Progression: Sustainable Learning in Higher Education

ERIC Educational Resources Information Center

Rovio-Johansson, Airi

2016-01-01

The purpose of this phenomenographic study is to examine students' knowledge progression in a three-year Bachelor program in Business Administration. Theoretical sampling was used to select nine students from a group of 200 university students admitted to the program. The students were interviewed on three occasions: Year 1, after their Management…

Flaying Freire? The Workers' Party and Education Policy in Brazil, 1980-2007

ERIC Educational Resources Information Center

Burton, Guy

2012-01-01

This article analyses the progression of education policy by the Workers' Party (PT) in Brazil from its experience of municipal administration to national government. The first section presents this development, noting its progression from a participatory, social(ist) project to a more reformist, elite-directed model. The second section accounts…

Application of the National Assessment of Educational Progress Philosophy in San Bernardino City Unified School District.

ERIC Educational Resources Information Center

Bonney, Lewis A.

the steps taken by a large urban school district to develop and implement an objectives-based curriculum with criterion-referenced assessment of student progress are described. These steps include: goal setting, development of curriculum objectives, construction of assessment exercises, matrix sampling in test administration, and reporting of…

Renewing America's Progress: A Positive Solution to School Reform.

ERIC Educational Resources Information Center

Genck, Fredric H.

This book was designed to help citizens evaluate and improve their local schools. It contends that the solution to the potential end of America's progress is through positive school reform--the public management of schools. It presents a system of participative and results-oriented management that is implemented by boards, administrators, and…

A Safe and Welcoming Place?: Workplace Progression for Women Staff.

ERIC Educational Resources Information Center

Gardiner, Jean; O'Rourke, Rebecca

1995-01-01

Interviews with seven women lecturers and five administrative/library staff at Leeds University uncovered the following: differential career paths for women and men; a link between the extent of career progression and working full or part time; and few opportunities for gender issues to be openly discussed in the academic workplace. (SK)

A Goal for North Carolina's Schools. First in America 2001 Progress Report.

ERIC Educational Resources Information Center

Cunningham, Elizabeth Kolb, Ed.; Thompson, Charles L., Ed.

This second annual report details North Carolina's performance and progress since 2000 in the five goal areas: high student performance; every child ready to learn; safe, orderly, and caring schools; quality teachers and administrators; and strong family, business, and community support. Over the years, North Carolina's education system has…

28 CFR 16.97 - Exemption of Bureau of Prisons Systems-limited access.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-limited access. 16.97 Section 16.97 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE... progresses or with the passage of time, and could be relevant to future law enforcement decisions. (9) From... progresses. Also, some of these records may come from other Federal, State, local and foreign law enforcement...

28 CFR 16.97 - Exemption of Bureau of Prisons Systems-limited access.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-limited access. 16.97 Section 16.97 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE... progresses or with the passage of time, and could be relevant to future law enforcement decisions. (9) From... progresses. Also, some of these records may come from other Federal, State, local and foreign law enforcement...

The Progressive Discipline Matrix and Its Effects on Discipline in High Schools

ERIC Educational Resources Information Center

Jones, Vincent L.

2017-01-01

The purpose of this mixed-method case study was to determine the effectiveness of the progressive discipline matrix in high schools in one Tennessee school district. The further intent was to investigate how discipline practices influenced the perceptions of teachers and administrators. Findings from quantitative data stated that progressive…

Development and operations of the astrophysics data system

NASA Technical Reports Server (NTRS)

Murray, S. S.

1996-01-01

Monthly progress reports are given for the period October 1993 through March 1994. Each month's progress includes a general summary and overviews of Administrative functions, Systems Engineering, User Committee, User Support, Test and QA, System Integration, Development, Operations, and Suppliers of Data. These overviews include user and query statistics for the month.

Creating a Government That Works Better & Costs Less. Status Report. Report of the National Performance Review.

ERIC Educational Resources Information Center

Gore, Al

This publication reports on progress 1 year into the Clinton Administration's "Reinventing Government" initiative, a long-term effort at significantly revamping the federal government's operations. A preliminary chapter notes the culture change involved in the reinvention process. Individual chapters then report progress for each of the…

Pyrogenic renal hyperemia: the role of prostaglandins.

PubMed

Gagnon, J A; Ramwell, P W; Flamenbaum, W

1978-01-01

The intravenous administration of triple typhoid vaccine to anesthetized dogs resulted in a significant increase in renal blood flow accompanied by a modest decline in systemic blood pressure. This renal hyperemia was associated with elevated renal secretory rates of renin and prostaglandin E and F. Measurements of the intracortical distribution of radiolabeled microspheres revealed a progressive decrease in outer cortical blood flow rates and a progressive increase in inner cortical flow rates. When meclofenamate, an inhibitor of prostaglandin synthetase, was administered concomitantly with triple typhoid vaccine renal hyperemia did not develop. The renal renin secretory rate increased modestly and intracortical renal blood flow was not redistributed. The increased renal blood flow after triple typhoid vaccine administration to unanesthetized dogs was also reversed by meclofenamate. The marked increase in prostaglandin secretion by the kidney during renal hyperemia following triple typhoid vaccine administration (pyrogen), and the effect of meclofenamate, is consonant with a role for increased renal synthesis and release of prostaglandins.

Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death.

PubMed

Yadav, Saveg; Kujur, Praveen Kumar; Pandey, Shrish Kumar; Goel, Yugal; Maurya, Babu Nandan; Verma, Ashish; Kumar, Ajay; Singh, Rana Pratap; Singh, Sukh Mahendra

2018-01-15

Evidences demonstrate that metabolic inhibitor 3-bromopyruvate (3-BP) exerts a potent antitumor action against a wide range of malignancies. However, the effect of 3-BP on progression of the tumors of thymic origin remains unexplored. Although, constituents of tumor microenvironment (TME) plays a pivotal role in regulation of tumor progression, it remains unclear if 3-BP can alter the composition of the crucial tumor growth regulatory components of the external surrounding of tumor cells. Thus, the present investigation attempts to understand the effect of 3-BP administration to a host bearing a progressively growing tumor of thymic origin on tumor growth regulatory soluble, cellular and biophysical components of tumor milieu vis-à-vis understanding its association with tumor progression, accompanying cell cycle events and mode of cell death. Further, the expression of cell survival regulatory molecules and hemodynamic characteristics of the tumor milieu were analysed to decipher mechanisms underlying the antitumor action of 3-BP. Administration of 3-BP to tumor-bearing hosts retarded tumor progression accompanied by induction of tumor cell death, cell cycle arrest, declined metabolism, inhibited mitochondrial membrane potential, elevated release of cytochrome c and altered hemodynamics. Moreover, 3-BP reconstituted the external milieu, in concurrence with deregulated glucose and pH homeostasis and increased tumor infiltration by NK cells, macrophages, and T lymphocytes. Further, 3-BP administration altered the expression of key regulatory molecules involved in glucose uptake, intracellular pH and tumor cell survival. The outcomes of this study will help in optimizing the therapeutic application of 3-BP by targeting crucial tumor growth regulatory components of tumor milieu. Copyright © 2017 Elsevier Inc. All rights reserved.

Biogas Opportunities Roadmap Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

Health information technology and implementation science: partners in progress in the VHA.

PubMed

Hynes, Denise M; Whittier, Erika R; Owens, Arika

2013-03-01

The Department of Veterans Affairs (VA) Quality Enhancement Research Initiative (QUERI) has demonstrated how implementation science can enhance the quality of health care. During this time an increasing number of implementation research projects have developed or utilized health information technology (HIT) innovations to leverage the VA's electronic health record and information systems. To describe the HIT approaches used and to characterize the facilitators and barriers to progress within implementation research projects in the VA QUERI program. Nine case studies were selected from among 88 projects and represented 8 of 14 HIT categories identified. Each case study included key informants whose roles on the project were principal investigator, implementation science and informatics development. We conducted documentation analysis and semistructured in-person interviews with key informants for each of the 9 case studies. We used qualitative analysis software to identify and thematically code information and interview responses. : Thematic analyses revealed 3 domains or pathways critical to progression through the QUERI steps. These pathways addressed: (1) compliance and collaboration with information technology policies and procedures; (2) operating within organizational policies and building collaborations with end users, clinicians, and administrators; and (3) obtaining and maintaining research resources and approvals. Sustained efforts in HIT innovation and in implementation science in the Veterans Health Administration demonstrates the interdependencies of these initiatives and the critical pathways that can contribute to progress. Other health care quality improvement efforts that rely on HIT can learn from the Veterans Health Administration experience.

Allopurinol Against Progression of Chronic Kidney Disease.

PubMed

Golmohammadi, Sima; Almasi, Afshin; Manouchehri, M; Omrani, Hamid Reza; Zandkarimi, Mohammad Reza

2017-07-01

Hyperuricemia is common in approximately 50% of patients with kidney failure due to decreased uric acid excretion, and it has been recently known as an independent factor in the progression of renal insufficiency. Allopurinol inhibits the production of uric acid. The aim of this study was to evaluate the effect of allopurinol on chronic kidney disease progression. In a clinical trial, patients with stages 3 and 4 of chronic kidney disease were divided into two groups to receive allopurinol, 100 mg, daily and placebo for 12 months. Patients' kidney function and serum uric acid levels were assessed at baseline and 3, 6, and 12 months after initial administration. Subgroups of patients with severe and mild glomerular filtration rate (GFR) impairment (GFR, 15 mL/min/1.73 m2 to 30 mL/min/1.73 m2 and 30 mL/min/1.73 m2 to 60 mL/min/1.73 m2, respectively), were compared between the groups. Serum uric acid levels decreased significantly during after 12 months of allopurinol administration (P = .004). In patients with severe GFR impairment, serum creatinine levels did not decrease significantly and there was no significant increase in GFR, but in those with mild GFR impairment, serum creatinine levels decreased and GFR increase significantly (P < .001) after administration of allopurinol. These effects were not observed in the control subgroups. Allopurinol may slow down stage 3 chronic kidney disease progression and could be administered with other effective medications for controlling the kidney disease.

Cannabinoid administration attenuates the progression of simian immunodeficiency virus.

PubMed

Molina, Patricia E; Winsauer, Peter; Zhang, Ping; Walker, Edith; Birke, Leslie; Amedee, Angela; Stouwe, Curtis Vande; Troxclair, Dana; McGoey, Robin; Varner, Kurt; Byerley, Lauri; LaMotte, Lynn

2011-06-01

Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), the primary psychoactive component in marijuana, is FDA approved to ameliorate AIDS-associated wasting. Because cannabinoid receptors are expressed on cells of the immune system, chronic Δ(9)-THC use may impact HIV disease progression. We examined the impact of chronic Δ(9)-THC administration (0.32 mg/kg im, 2 × daily), starting 28 days prior to inoculation with simian immunodeficiency virus (SIV(mac251); 100 TCID(50)/ml, iv), on immune and metabolic indicators of disease during the initial 6 month asymptomatic phase of infection in rhesus macaques. SIV(mac251) inoculation resulted in measurable viral load, decreased lymphocyte CD4(+)/CD8(+) ratio, and increased CD8(+) proliferation. Δ(9)-THC treatment of SIV-infected animals produced minor to no effects in these parameters. However, chronic Δ(9)-THC administration decreased early mortality from SIV infection (p = 0.039), and this was associated with attenuation of plasma and CSF viral load and retention of body mass (p = NS). In vitro, Δ(9)-THC (10 μm) decreased SIV (10 TCID(50)) viral replication in MT4-R5 cells. These results indicate that chronic Δ(9)-THC does not increase viral load or aggravate morbidity and may actually ameliorate SIV disease progression. We speculate that reduced levels of SIV, retention of body mass, and attenuation of inflammation are likely mechanisms for Δ(9)-THC-mediated modulation of disease progression that warrant further study.

School Districts of South Carolina: Organization and Administration.

ERIC Educational Resources Information Center

Stuckey, Dale C.; Haines, Preston B.

This publication is an update and expansion of earlier studies on the legal organization and administration of school districts in South Carolina. The treatment of this topic progresses from the general to the specific and includes detailed data about the geographical, organizational, financial, and legal aspects of the topic. The report attempts…

Distributed Leadership as Administrative Practice in Finnish Early Childhood Education and Care

ERIC Educational Resources Information Center

Kangas, Jonna; Venninen, Tuulikki; Ojala, Mikko

2016-01-01

In this article, we describe the professional development towards distributed leadership among different organizational levels in Finnish day care centres within the Helsinki metropolitan area. The aim of the study was to monitor the progress of professional development between educational administration and practitioners. The data was based on…

The Carter Administration and Civil Rights; An Assessment of the First Year.

ERIC Educational Resources Information Center

Taylor, William; And Others

In this paper the first year accomplishments and failings of the Carter Administration in civil rights enforcement are assessed. Areas considered include the following: leadership and management, employment, education, housing, health and social services, and veterans affairs. Enforcement in some areas has improved but progress has been slow and…

Barriers and Biases toward Women: Impediments to Administrative Progression.

ERIC Educational Resources Information Center

Fobbs, Joan.

Barriers to administrative advancement for women in academe are discussed. A study of perceived managerial style and leadership skill of women two-year college presidents was designed to fill a gap in research during an era of significant advancement opportunities for women. Leadership in higher education in the United States is gradually…

Report to Congress on the National Highway Traffic Safety Administration ITS Program : program progress during 1992-1996 and strategic plan for 1997-2002

DOT National Transportation Integrated Search

1997-01-01

Congress recently requested the Intelligent Transportation Systems (ITS) Joint Program Office and the National Highway Traffic Safety Administration to update the 1992 ITS plan to deal with the fiscal year 1997 through fiscal year 2002 period, and...

Technical Adequacy of Growth Estimates from a Computer Adaptive Test: Implications for Progress Monitoring

ERIC Educational Resources Information Center

Van Norman, Ethan R.; Nelson, Peter M.; Parker, David C.

2017-01-01

Computer adaptive tests (CATs) hold promise to monitor student progress within multitiered systems of support. However, the relationship between how long and how often data are collected and the technical adequacy of growth estimates from CATs has not been explored. Given CAT administration times, it is important to identify optimal data…

Unfinished Agendas: New and Continuing Gender Challenges in Higher Education

ERIC Educational Resources Information Center

Glazer-Raymo, Judith, Ed.

2008-01-01

This revealing volume examines the current role and status of women in higher education--and suggests a direction for the future. Judith Glazer-Raymo and other distinguished scholars and administrators assess the progress of women in academe using three lenses: the feminist agenda as a work in progress, growing internal and external challenges to…

Annual Progress Report of the Coastal Bend Migrant Council Health Project, San Patricio Migrant Health Center (Texas), 1973-1974.

ERIC Educational Resources Information Center

Coastal Bend Migrant Council, Mathis, TX. San Patricio Migrant Health Center.

The annual medical progress report covers migrant health services in San Patricio County, Texas, from February 1, 1973 to January 31, 1974. The report discusses: staff, administration, cardiology, dental services, health services, medical services, outreach and environmental health services, prescription services, registration and identification,…

Implementing a Multi-Tiered System of Support (MTSS): Collaboration between School Psychologists and Administrators to Promote Systems-Level Change

ERIC Educational Resources Information Center

Eagle, John W.; Dowd-Eagle, Shannon E.; Snyder, Andrew; Holtzman, Elizabeth Gibbons

2015-01-01

Current educational reform mandates the implementation of school-based models for early identification and intervention, progress monitoring, and data-based assessment of student progress. This article provides an overview of interdisciplinary collaboration for systems-level consultation within a Multi-Tiered System of Support (MTSS) framework.…

The 2008 National Assessment of Educational Progress (NAEP): A Visual Arts Replication Study

ERIC Educational Resources Information Center

Heid, Karen

2016-01-01

The 2008 National Assessment of Educational Progress (NAEP) Arts Assessment was administered to selected 8th grade students throughout the nation, and in 2009 the results from that administration were publicly reported. In the spring of 2010, building on the format and structure of the 2008 national assessment, the researcher administered a…

Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration

USDA-ARS?s Scientific Manuscript database

A new method of experimental infection of ovine progressive pneumonia virus (OPPV), aerosol nebulization (Nb), was compared to intravenous (IV) and oral (PO) methods of experimental infection. Seven month old lambs were given 3.5 × 107 TCID50 of Dubois OPPV LMH19 isolate using IV, PO, or Nb methods ...

20 CFR 411.205 - What if I disagree with the PM's decision about whether I am making timely progress toward self...

Code of Federal Regulations, 2010 CFR

2010-04-01

... about whether I am making timely progress toward self-supporting employment? 411.205 Section 411.205 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM...-supporting employment? If you disagree with the PM's decision, you may request that we review the decision...

Common Sense Government. Works Better and Costs Less. Third Report of the National Performance Review.

ERIC Educational Resources Information Center

Gore, Al

This publication reports on the progress of the Clinton Administration's effort to reinvent the Federal government bureaucracy and how it operates and serves citizens. Part 1, "A Government that Makes Sense," describes the progress that reinventing government has made and reviews the context in which the initiative was launched including…

Designing Research Services: Cross-Disciplinary Administration and the Research Lifecycle

NASA Astrophysics Data System (ADS)

Madden, G.

2017-12-01

The sheer number of technical and administrative offices involved in the research lifecycle, and the lack of shared governance and shared processes across those offices, creates challenges to the successful preservation of research outputs. Universities need a more integrated approach to the research lifecycle that allows us to: recognize a research project as it is being initiated; identify the data associated with the research project; document and track any compliance, security, access, and publication requirements associated with the research and its data; follow the research and its associated components across the research lifecycle; and finally recognize that the research has come to a close so we can trigger the various preservation, access, and communications processes that close the loop, inform the public, and promote the continued progress of science. Such an approach will require cooperation, communications, and shared workflow tools that tie together (often across many years) PIs, research design methodologists, grants offices, contract negotiators, central research administrators, research compliance specialists, desktop IT support units, server administrators, high performance computing facilities, data centers, specialized data transfer networks, institutional research repositories, institutional data repositories, and research communications groups, all of which play a significant role in the technical or administrative success of research. This session will focus on progress towards improving cross-disciplinary administrative and technical cooperation at Penn State University, with an emphasis on generalizable approaches that can be adopted elsewhere.

Home administration of maintenance pemetrexed for patients with advanced non-squamous non-small cell lung cancer: rationale, practicalities and phase II feasibility study design.

PubMed

Lal, Rohit; Bourayou, Nawel; Hillerdal, Gunnar; Nicolson, Marianne; Vikstrom, Anders; Lorenzo, Maria; D'yachkova, Yulia; Barriga, Susana; Visseren-Grul, Carla

2013-10-03

Home-based care in oncology is mainly reserved for patients at the end of life. Regulations regarding home delivery of cytotoxics differ across Europe, with a notable lack of practice guidelines in most countries. This has led to a lack of data addressing the feasibility of home-based administration of cytotoxic chemotherapy. In advanced non-squamous non-small cell lung cancer, pemetrexed is approved as maintenance therapy after first-line chemotherapy. In this setting, patients have the potential to be treated long-term with maintenance therapy, which, in the absence of unacceptable toxicity, is continued until disease progression. The favourable safety profile of pemetrexed and the ease of its administration by 10-minute intravenous infusion every 3 weeks make this drug a suitable candidate for administration in a home setting. Literature and regulations relevant to the home-based delivery of cytotoxic therapy were reviewed, and a phase II feasibility study of home administration of pemetrexed maintenance therapy was designed. At least 50 patients with advanced non-squamous non-small cell lung cancer, Eastern Cooperative Oncology Group performance status 0-1 and no progressive disease after four cycles of platinum-based first-line therapy are required to allow investigation of the feasibility of home-based administration of pemetrexed maintenance therapy (500 mg/m(2) every 3 weeks until progressive disease or unacceptable toxicity). Feasibility is being assessed as adherence to the home-based administration process (primary endpoint), patient safety, impact on patients' quality of life, patient and physician satisfaction with home care, and healthcare resource use and costs. Enrolment of patients from the UK and Sweden, where home-based care is relatively well developed, commenced in December 2011. This feasibility study addresses an important aspect of maintenance therapy, that is, patient comfort during protracted home-based chemotherapy. The study design requires unusual methodology and specific logistics to address outcomes relevant to the home-delivery approach. This article presents a study design that offers a novel and reproducible model for home-based chemotherapy, and provides an up-to-date overview of the literature regarding this type of treatment. ClinicalTrials.gov: NCT01473563.

Protective effects of long-term lithium administration in a slowly progressive SMA mouse model.

PubMed

Biagioni, Francesca; Ferrucci, Michela; Ryskalin, Larisa; Fulceri, Federica; Lazzeri, Gloria; Calierno, Maria Teresa; Busceti, Carla L; Ruffoli, Riccardo; Fornai, Francesco

2017-12-01

In the present study we evaluated the long-term effects of lithium administration to a knock-out double transgenic mouse model (Smn-/-; SMN1A2G+/-; SMN2+/+) of Spinal Muscle Atrophy type III (SMA-III). This model is characterized by very low levels of the survival motor neuron protein, slow disease progression and motor neuron loss, which enables to detect disease-modifying effects at delayed time intervals. Lithium administration attenuates the decrease in motor activity and provides full protection from motor neuron loss occurring in SMA-III mice, throughout the disease course. In addition, lithium prevents motor neuron enlargement and motor neuron heterotopy and suppresses the occurrence of radial-like glial fibrillary acidic protein immunostaining in the ventral white matter of SMA-III mice. In SMA-III mice long-term lithium administration determines a dramatic increase of survival motor neuron protein levels in the spinal cord. These data demonstrate that long-term lithium administration during a long-lasting motor neuron disorder attenuates behavioural deficit and neuropathology. Since low level of survival motor neuron protein is bound to disease severity in SMA, the robust increase in protein level produced by lithium provides solid evidence which calls for further investigations considering lithium in the long-term treatment of spinal muscle atrophy.

Building Consensus for Change: Developing an Administrative and Management Structure in a Southern African University.

ERIC Educational Resources Information Center

Ingalls, Wayne B.

1995-01-01

The way in which the University of Botswana went about building the consensus necessary to develop a new administrative and management structure is described. The process began with a commission review to address increasing demand, and progressed to recommendations, governing council response, a task force for reorganization, and implementation.…

The Power of the President: Recommendations to Advance Progressive Change

ERIC Educational Resources Information Center

Wartell, Sarah Rosen, Comp.

2010-01-01

Concentrating on executive powers presents a real opportunity for the Obama administration to turn its focus away from a divided Congress and the unappetizing process of making legislative sausage. Instead, the administration can focus on the president's ability to deliver results for the American people on the things that matter most to them. The…

Effects of Administrator Performance on Student Performance in the Trial State Assessment.

ERIC Educational Resources Information Center

McLaughlin, Donald H.

In 1990 the scope of the National Assessment of Educational Progress (NAEP) was broadened by adding the Trial State Assessment (TSA), in which approximately 2,500 eighth graders in 100 schools in 40 states and U.S. territories participated in the mathematics assessment. A major step was training local test administrators to administer the TSA…

Women of Color in Higher Education Administration: An Exploration of Barriers to Advancement

ERIC Educational Resources Information Center

Smith, LaVonia

2012-01-01

Women in general have made vast progress in gaining leadership positions in higher education administration; however, women of color, including Asian Americans, Native Americans, and Latinas, continue to lag behind. According to the literature, a number of issues prevent women of color from achieving senior-level positions. A dissertation study by…

32 CFR 37.1100 - What are my responsibilities generally as an administrative agreements officer for a TIA?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false What are my responsibilities generally as an administrative agreements officer for a TIA? 37.1100 Section 37.1100 National Defense Department of Defense... status reports, programmatic progress reports, and patent reports. (d) Handling payment requests and...

32 CFR 37.1100 - What are my responsibilities generally as an administrative agreements officer for a TIA?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false What are my responsibilities generally as an administrative agreements officer for a TIA? 37.1100 Section 37.1100 National Defense Department of Defense... status reports, programmatic progress reports, and patent reports. (d) Handling payment requests and...

32 CFR 37.1100 - What are my responsibilities generally as an administrative agreements officer for a TIA?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false What are my responsibilities generally as an administrative agreements officer for a TIA? 37.1100 Section 37.1100 National Defense Department of Defense... status reports, programmatic progress reports, and patent reports. (d) Handling payment requests and...

32 CFR 37.1100 - What are my responsibilities generally as an administrative agreements officer for a TIA?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false What are my responsibilities generally as an administrative agreements officer for a TIA? 37.1100 Section 37.1100 National Defense Department of Defense... status reports, programmatic progress reports, and patent reports. (d) Handling payment requests and...

32 CFR 37.1100 - What are my responsibilities generally as an administrative agreements officer for a TIA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false What are my responsibilities generally as an administrative agreements officer for a TIA? 37.1100 Section 37.1100 National Defense Department of Defense... status reports, programmatic progress reports, and patent reports. (d) Handling payment requests and...

Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression.

PubMed

Tampe, Björn; Steinle, Ulrike; Tampe, Désirée; Carstens, Julienne L; Korsten, Peter; Zeisberg, Elisabeth M; Müller, Gerhard A; Kalluri, Raghu; Zeisberg, Michael

2017-01-01

Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied syndromes. In this regard, the acutely injured kidney often does not achieve its full regenerative capacity and AKI directly transitions into progressive CKD associated with tubulointerstitial fibrosis. Underlying mechanisms of such AKI-to-CKD progression are still incompletely understood and specific therapeutic interventions are still elusive. Because epigenetic modifications play a role in maintaining tissue fibrosis, we used a murine model of ischemia-reperfusion injury to determine whether aberrant promoter methylation of RASAL1 contributes causally to the switch between physiological regeneration and tubulointerstitial fibrogenesis, a hallmark of AKI-to-CKD progression. It is known that the antihypertensive drug hydralazine has demethylating activity, and that its optimum demethylating activity occurs at concentrations below blood pressure-lowering doses. Administration of low-dose hydralazine effectively induced expression of hydroxylase TET3, which catalyzed RASAL1 hydroxymethylation and subsequent RASAL1 promoter demethylation. Hydralazine-induced CpG promoter demethylation subsequently attenuated renal fibrosis and preserved excretory renal function independent of its blood pressure-lowering effects. In comparison, RASAL1 demethylation and inhibition of tubulointerstitial fibrosis was not detected upon administration of the angiotensin-converting enzyme inhibitor Ramipril in this model. Thus, RASAL1 promoter methylation and subsequent transcriptional RASAL1 suppression plays a causal role in AKI-to-CKD progression. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Center for Information Services Fourth Quarterly Progress Report, Phase IIB; Detailed Design and Prototype Development, 1 October 1971 to 31 December 1971.

ERIC Educational Resources Information Center

Kehl, W. B.; And Others

The administrative activity, including organization, staff, budget and external contacts, and the technical progress of IPS development, experimental service, workshops, documentation and related activities of the Center for Information Services (at the University of California, Los Angeles) are reported upon in this document. Pages 9 and 10 may…

THE DEVELOPMENT OF PRE-VOCATIONAL EDUCATION LITERACY COURSES FOR USE WITH COMPUTER ASSISTED INSTRUCTION OF DISADVANTAGED YOUTH AND ADULTS. TECHNICAL PROGRESS REPORT.

ERIC Educational Resources Information Center

HANKIN, EDWARD K.; AND OTHERS

THIS TECHNICAL PROGRESS REPORT COVERS THE FIRST THREE MONTHS OF A PROJECT TO DEVELOP COMPUTER ASSISTED PREVOCATIONAL READING AND ARITHMETIC COURSES FOR DISADVANTAGED YOUTHS AND ADULTS. DURING THE FIRST MONTH OF OPERATION, PROJECT PERSONNEL CONCENTRATED ON SUCH ADMINISTRATIVE MATTERS AS TRAINING STAFF AND PREPARING FACILITIES. AN ARITHMETIC PROGRAM…

The Failure of Progressive Classroom Reform: Lessons from the Curriculum Reform Implementation Project in Papua New Guinea

ERIC Educational Resources Information Center

Guthrie, Gerard

2012-01-01

Progressive education has been an article of educational faith in Papua New Guinea during the last 50 years but the best available evidence indicates that major reforms to formalistic curriculum and teaching in primary and secondary classrooms have failed during this period despite large-scale professional, administrative and financial support. In…

Salmon cartilage proteoglycan suppresses mouse experimental colitis through induction of Foxp3{sup +} regulatory T cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitsui, Toshihito; Department of Digestive Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562; Sashinami, Hiroshi

Research highlights: {yields} Salmon proteoglycan suppresses IL-10{sup -/-} cell transfer-induced colitis progression. {yields} Salmon proteoglycan suppresses Th1- and Th17-related factors in colitis mice. {yields} Salmon proteoglycan enhances Foxp3 expression. -- Abstract: Proteoglycans (PGs) are complex glycohydrates which are widely distributed in extracellular matrix (ECM). PGs are involved in the construction of ECM, cell proliferation and differentiation. ECM components are involved in transduction of proinflammatory responses, but it is still unknown whether PGs are involved in inflammatory response. In this study, we investigated the effect of PG extracted from salmon cartilage on the progression of experimental colitis-induced in severe combined immunodeficiencymore » mice by cell transfer from interleukin-10 (IL-10){sup -/-} mice. IL-10{sup -/-} cell-transferred mice showed weight loss, colon shortening and histological appearance of mild colitis. Daily oral administration of PG attenuated the clinical progression of colitis in a dose-dependent manner. Colitis-induced mice showed the elevated expression of IFN-{gamma}, IL-12, TNF-{alpha}, IL-21, IL-23p19, IL-6, IL-17A and retinoic acid-related orphan receptor {gamma}t (ROR{gamma}t) in lamina propria mononuclear cells (LPMCs) and oral administration of PG suppressed the expression of these factors. Conversely, expression of Foxp3 that induces CD4{sup +}CD25{sup +} regulatory T cells in LPMCs was enhanced by PG administration. These findings suggested that salmon PG attenuated the progression of colitis due to suppression of inflammatory response by enhancement of regulatory T cell induction.« less

Frequency of use of the International Classification of Diseases ICD-10 diagnostic categories for mental and behavioural disorders across world regions.

PubMed

Faiad, Y; Khoury, B; Daouk, S; Maj, M; Keeley, J; Gureje, O; Reed, G

2017-11-09

The study aimed to examine variations in the use of International Classification of Diseases, Tenth Edition (ICD-10) diagnostic categories for mental and behavioural disorders across countries, regions and income levels using data from the online World Psychiatric Association (WPA)-World Health Organization (WHO) Global Survey that examined the attitudes of psychiatrists towards the classification of mental disorders. A survey was sent to 46 psychiatric societies which are members of WPA. A total of 4887 psychiatrists participated in the survey, which asked about their use of classification, their preferred system and the categories that were used most frequently. The majority (70.1%) of participating psychiatrists (out of 4887 psychiatrists) reported using the ICD-10 the most and using at least one diagnostic category once a week. Nine out of 44 diagnostic categories were considerably variable in terms of frequency of use across countries. These were: emotionally unstable personality disorder, borderline type; dissociative (conversion) disorder; somatoform disorders; obsessive-compulsive disorder (OCD); mental and behavioural disorders due to the use of alcohol; adjustment disorder; mental and behavioural disorders due to the use of cannabinoids; dementia in Alzheimer's disease; and acute and transient psychotic disorder. The frequency of use for these nine categories was examined across WHO regions and income levels. The most striking differences across WHO regions were found for five out of these nine categories. For dissociative (conversion) disorder, use was highest for the WHO Eastern Mediterranean Region (EMRO) and non-existent for the WHO African Region. For mental and behavioural disorders due to the use of alcohol, use was lowest for EMRO. For mental and behavioural disorders due to the use of cannabinoids, use was lowest for the WHO European Region and the WHO Western Pacific Region. For OCD and somatoform disorders, use was lowest for EMRO and the WHO Southeast Asian Region. Differences in the frequency of use across income levels were statistically significant for all categories except for mental and behavioural disorders due to the use of alcohol. The most striking variations were found for acute and transient psychotic disorder, which was reported to be more commonly used among psychiatrists from countries with lower income levels. The differences in frequency of use reported in the current study show that cross-cultural variations in psychiatric practice exist. However, whether these differences are due to the variations in prevalence, treatment-seeking behaviour and other factors, such as psychiatrist and patient characteristics as a result of culture, cannot be determined based on the findings of the study. Further research is needed to examine whether these variations are culturally determined and how that would affect the cross-cultural applicability of ICD-10 diagnostic categories.

Mefloquine improved progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus.

PubMed

Beppu, Minako; Kawamoto, Michi; Nukuzuma, Souichi; Kohara, Nobuo

2012-01-01

We describe a case of a 67-year-old man with systemic lupus erythematosus who presented with progressive left hemiplegia. Although the cerebral spinal fluid (CSF) polymerase chain reaction (PCR) for the JC virus was negative, a brain biopsy confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML). The tapering of prednisone and the use of cidofovir could not arrest the disease progression. Administration of mefloquine stopped the extension of the lesion, and resulted in obvious clinical improvement. The CSF nested PCR for the JC virus also became negative. This widely used drug should be tried for the treatment of non-HIV PML.

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator for Human Exploration and Operations, William Gerstenmaier, right, talks as NASA Associate Administrator Robert Lightfoot, left, NASA Associate Administrator Science John Grunsfeld, Ph.D, second from left, and NASA Associate Administrator for Space Technology, Mike Gazarik, Ph.D, look on during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Robert Lightfoot, left, talks as NASA Associate Administrator Science John Grunsfeld, Ph.D, second from left, NASA Associate Administrator for Space Technology, Mike Gazarik, Ph.D, and, NASA Associate Administrator for Human Exploration and Operations, William Gerstenmaier, right, look on during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Procedures for Handling Retaliation Complaints Under Section 31307 of the Moving Ahead for Progress in the 21st Century Act (MAP-21). Final rule.

PubMed

2016-12-14

On March 16, 2016, the Occupational Safety and Health Administration (OSHA) of the U.S. Department of Labor (Department) issued an interim final rule (IFR) that provided procedures for the Department's processing of complaints under the employee protection (retaliation or whistleblower) provisions of Section 31307 of the Moving Ahead for Progress in the 21st Century Act (MAP-21). The IFR established procedures and time frames for the handling of retaliation complaints under MAP-21, including procedures and time frames for employee complaints to OSHA, investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor) and judicial review of the Secretary's final decision. It also set forth the Department's interpretations of the MAP-21 whistleblower provisions on certain matters. This final rule adopts, without change, the IFR.

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance... cognizant technical officer, to maintain adequate knowledge of the contractor's activities and progress in...

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance... cognizant technical officer, to maintain adequate knowledge of the contractor's activities and progress in...

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance... cognizant technical officer, to maintain adequate knowledge of the contractor's activities and progress in...

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance... cognizant technical officer, to maintain adequate knowledge of the contractor's activities and progress in...

34 CFR 646.30 - What are allowable costs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... participant development, project administration, or project recordkeeping. (g) Professional development travel... of the participants' academic progress and personal development. (e) Transportation and, with the...

Technical Report of the NAEP Mathematics Assessment in Puerto Rico: Focus on Statistical Issues. NCES 2007-462

ERIC Educational Resources Information Center

Baxter, G. P.; Ahmed, S.; Sikali, E.; Waits, T.; Sloan, M.; Salvucci, S.

2007-01-01

In 2003, a trial National Assessment of Educational Progress (NAEP) mathematics assessment was administered in Spanish to public school students at grades 4 and 8 in Puerto Rico. Based on preliminary analyses of the 2003 data, changes were made in administration and translation procedures for the 2005 NAEP administration in Puerto Rico. This…

Standards-Based Accountability under No Child Left Behind: Experiences of Teachers and Administrators in Three States. MG-589-NSF

ERIC Educational Resources Information Center

Hamilton, Laura S.; Stecher, Brian M.; Marsh, Julie A.; McCombs, Jennifer Sloan; Robyn, Abby; Russell, Jennifer; Naftel, Scott; Barney, Heather

2007-01-01

Since 2001-2002, standards-based accountability (SBA) provisions of the No Child Left Behind Act of 2001 (NCLB) have shaped the work of public school teachers and administrators in the United States. NCLB requires each state to develop content and achievement standards in several subjects, administer tests to measure students' progress toward…

African American Women in Public Higher Education Administrative Leadership in the State of Missouri: Perspectives on a Half Century of Progress

ERIC Educational Resources Information Center

Mays, Vida A.

2013-01-01

This study explores the lived experiences of six African American female administrators in Missouri public higher educational institutions. The Black Feminist Thought theory as espoused by Patricia Collins is the framework with which this research examines their leadership. The conceptual lens of race, gender, and class offers an opportunity to…

Making Progress: An Update on State Implementation of Federal Education Laws Enacted in 1994.

ERIC Educational Resources Information Center

Anderson, Leslie M.; Welsh, Megan

This study focuses on the work of state administrators of federal programs. It follows up on baseline information collected during late fall 1996 and early winter 1997, analyzing the ways in which state administrators have continued to respond to the new laws. The programs included in the follow-up study are as follows: the Goals 2000: Educate…

Leaders for a Movement: Professional Preparation and Development of Middle Level Teachers and Administrators. The Handbook of Research in Middle Level Education.

ERIC Educational Resources Information Center

Andrews, P. Gayle, Ed.; Anfara, Vincent A., Jr., Ed.

Papers included in this volume include: "Leaders for Movement: An Introduction to the Professional Preparation and Development of Middle Level Teachers and Administrators" (P. Gayle Andrews and Vincent A. Anfara, Jr.); (1) "Middle Level Teacher Preparation: Status, Progress, and Challenges" (C. Kenneth McEwin, Tracy W. Smith,…

Oral administration of Saccharomyces boulardii ameliorates carbon tetrachloride-induced liver fibrosis in rats via reducing intestinal permeability and modulating gut microbial composition.

PubMed

Li, Ming; Zhu, Lin; Xie, Ao; Yuan, Jieli

2015-02-01

To investigate the effects of orally administrated Saccharomyces boulardii (S. boulardii) on the progress of carbon tetrachloride (CCl4)-induced liver fibrosis, 34 male Wistar rats were randomly divided into four experimental groups including the control group (n = 8), the cirrhotic group (n = 10), the preventive group (n = 8), and the treatment group (n = 8). Results showed that the liver expression levels of collagen, type I, alpha 1 (Col1A1), alpha smooth muscle actin (αSMA), transforming growth factor beta (TGF-β) and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) increased significantly in cirrhotic rats compared with control and decreased by S. boulardii administration. Treatment of S. boulardii also attenuated the increased endotoxin levels and pro-inflammatory cytokines in CCl4-treated rats. And, these were associated with the changes of intestinal permeability and fecal microbial composition. Our study suggested that oral administration of S. boulardii can promote the liver function of CCl4-treated rats, and the preventive treatment of this probiotic yeast may decelerate the progress of liver fibrosis.

Inhibition of progression of androgen-dependent prostate LNCaP tumors to androgen independence in SCID mice by oral caffeine and voluntary exercise.

PubMed

Zheng, Xi; Cui, Xiao-Xing; Huang, Mou-Tuan; Liu, Yue; Wagner, George C; Lin, Yong; Shih, Weichung Joe; Lee, Mao-Jung; Yang, Chung S; Conney, Allan H

2012-01-01

The effect of oral caffeine or voluntary running wheel exercise (RW) alone or in combination on the progression of human androgen-dependent LNCaP prostate tumors to androgen independence in male severe combined immunodeficiency mice was determined. The mice were injected subcutaneously with LNCaP cells, and when the tumors reached a moderate size, the mice were surgically castrated and treated with caffeine (0.40 mg/ml drinking water) or RW alone or in combination for 42 days. We found that caffeine administration or RW inhibited the progression and growth of androgen-dependent LNCaP tumors to androgen independence, and a combination of the 2 regimens was more effective than the individual regimens alone. The ratios of the percent mitotic cells/caspase-3 positive cells in tumors from the caffeine-treated, RW-treated, or combination-treated mice were decreased by 34%, 38%, and 52%, respectively. Caffeine treatment increased the percentage of mitotic tumor cells undergoing apoptosis (lethal mitosis) whereas RW inhibited the increase in interleukin-6 that occurred during the progression of LNCaP tumors from androgen dependence to androgen independence. Our results indicate that oral administration of caffeine in combination with voluntary exercise may be an effective strategy for the prevention of prostate cancer progression from androgen dependence to androgen independence.

Artificial intelligence and deep learning - Radiology's next frontier?

PubMed

Mayo, Ray Cody; Leung, Jessica

Tracing the use of computers in the radiology department from administrative functions through image acquisition, storage, and reporting, to early attempts at improved diagnosis, we begin to imagine possible new frontiers for their use in exam interpretation. Given their initially slow but ultimately substantial progress in the noninterpretive areas, we are left desiring and even expecting more in the interpretation realm. New technological advances may provide the next wave of progress and radiologists should be early adopters. Several potential applications are discussed and hopefully will serve to inspire future progress. Published by Elsevier Inc.

Does administering a comprehensive examination affect pass rates on the Registered Health Information Administrator certification examination?

PubMed

McNeill, Marjorie H

2009-01-01

The purpose of this research study was to determine whether the administration of a comprehensive examination before graduation increases the percentage of students passing the Registered Health Information Administrator certification examination. A t-test for independent means yielded a statistically significant difference between the Registered Health Information Administrator certification examination pass rates of health information administration programs that administer a comprehensive examination and programs that do not administer a comprehensive examination. Programs with a high certification examination pass rate do not require a comprehensive examination when compared with those programs with a lower pass rate. It is concluded that health information administration faculty at the local level should perform program self-analysis to improve student progress toward achievement of learning outcomes and entry-level competencies.

Hazardous materials in aquatic environments of the Mississippi River Basin. Quarterly progress report, July 1, 1995--September 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-01

This report is the quarterly progress report for July through September 1995 for work done by Tulane and Xavier Universities under DOE contract number DE-FG01-93-EW53023. Accomplishments for various tasks including administrative activities, collaborative cluster projects, education projects, initiation projects, coordinated instrumentation facility, and an investigators` retreat are detailed in the report.

A Model for Developing a Continuous Progress Program, April 1977. A Manual for Teachers and Administrators Concerned with Improving Reading.

ERIC Educational Resources Information Center

Goldman, Rosalie; And Others

The focus of this manual is on the step-by-step development and implementation of a continuous-progress reading program--a system that permits instruction at each student's diagnosed level of ability. Analysis of program development includes advice on choosing a committee, writing the program, and presenting the program to others. The implications…

Update with 2009-10 Data and Five-Year Trends: How Many Schools Have Not Made Adequate Yearly Progress?

ERIC Educational Resources Information Center

Usher, Alexandra

2011-01-01

Recently, much attention has focused on the number of schools in the nation failing to make adequate yearly progress (AYP) in raising student achievement under the No Child Left Behind Act (NCLB). The Obama Administration has projected a dramatic increase in this number as 2014--the year when 100% of students are expected to score proficient on…

Investigation of Chitosan for Prevention of Diabetic Progression Through Gut Microbiota Alteration in Sugar Rich Diet Induced Diabetic Rats.

PubMed

Prajapati, Bhumika; Rajput, Parth; Jena, Prasant Kumar; Seshadri, Sriram

2015-01-01

Sugar rich diet induces inflammation and insulin resistance mainly through gut microbiota alteration. Gut microflora dysbiosis increases plasma lipopolysaccharide and reduces short chain fatty acids to impair the insulin signaling cascades by different molecular pathways to progress into diabetes. Chitosan based formulations have major significance in insulin delivery system due to their ability to protect the insulin from enzymatic degradation and its efficient inter-epithelial transport. This study was designed to investigate the effect of chitosan administration on gut microflora mediated signaling pathways to prevent the diet induced diabetes. Male wistar rats were divided into non-diabetic group with a normal diet (CD), diabetic group with high sucrose diet (HSD) and treatment group with HSD and chitosan (60 mg/kg). After 8 weeks of the study, significant alterations in two major gut dominant microbial phyla i.e Firmicutes and Bacteroides and four dominant microbial species i.e. Lactobacilli, Bifidobacteria, Escherichia and Clostridia were observed in HSD group compared to CD. This microbial dysbiosis in dominant phyla was significantly prevented in chitosan administrated HSD group. Chitosan administration had also reduced the HSD induced activation of Toll like receptors and Nod like receptors signaling pathways compared to HSD control group to reduce the inflammation. These suggest that chitosan can prevent the progression of Type 2 Diabetes through gut microbiota alteration, reducing endotoxin and microbes mediated inflammation.

Lamotrigine blocks repeated high-dose methamphetamine-induced behavioral sensitization to dizocilpine (MK-801), but not methamphetamine in rats.

PubMed

Nakato, Yasuya; Abekawa, Tomohiro; Inoue, Takeshi; Ito, Koki; Koyama, Tsukasa

2011-10-24

We recently proposed a new psychostimulant animal model of the progressive pathophysiological changes of schizophrenia. Studies using that model produced a treatment strategy for preventing progression. Lamotrigine (LTG) blocks repeated high-dosage methamphetamine (METH)-induced initiation and expression of prepulse inhibition deficit and development of apoptosis in the medial prefrontal cortex (mPFC). Moreover, it inhibits METH-induced increases in extracellular glutamate levels in the mPFC (Nakato et al., 2011, Neurosci. Lett.). Abnormal behavior induced by METH or NMDA receptor antagonists is regarded as an animal model of schizophrenia. This study examined the effects of LTG on the development of behavioral sensitization to METH and cross-sensitization to dizocilpine (MK-801) by repeated administration of high-dose METH (2.5mg/kg, 10 times s.c.). Rats were injected repeatedly with LTG (30mg/kg) after 120min METH administration (2.5mg/kg). Repeated co-administration of LTG blocked the development of behavioral cross-sensitization to MK-801 (0.15mg/kg), but it did not prevent behavioral sensitization to METH (0.2mg/kg). The LTG-induced prevention of increased glutamate by high-dose METH might be related to the former finding. Combined results of our previous studies and this study suggest that LTG is useful to treat schizophrenia, especially at a critical point in its progression. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Robert Lightfoot, left, talks as NASA Associate Administrator Science John Grunsfeld, Ph.D, listens, during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Robert Lightfoot, left, talks as NASA Associate Administrator Science John Grunsfeld, Ph.D, listens during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump.

PubMed

Ginsburg, Glen M; Lauder, Anthony J

2007-11-15

Medical and radiographic review of 19 consecutive patients with spastic quadriplegia before and after intrathecal baclofen pump insertion with special attention paid to progression of scoliosis. Many orthopedic surgeons who treat spastic quadriplegic patients have noticed a trend of marked scoliosis progression after the administration of intrathecal baclofen (ITB) via subcutaneous pump and catheter. The purpose of this study is to quantify scoliosis progression in this patient population before and after baclofen administration and compare this to published natural history data. The authors had noted rapid progression of scoliosis in spastic quadriplegic patients after intrathecal baclofen pump insertion. This had been noted at other centers, but no significant statistical analysis had been done comparing prepump to postpump scoliosis progression in these patients. To document the magnitude and rate of scoliosis progressions after the placement of an ITB pump, the charts and radiographs of 19 consecutive nonambulatory patients with spastic quadriplegia and an ITB pump were reviewed. To document the rate of scoliosis progression, each patient had at least 2 pre and 2 postpump insertion spinal radiographs made. All radiographs were made with the patients in the supine position without orthoses. A board-certified orthopedic surgeon reviewed these radiographs. Skeletal maturity was assessed using Risser grading. Catheter tip location and rate of baclofen administration were recorded. For 19 patients with complete radiographic data, average Cobb angles were 10.2 degrees before pump insertion and 25 degrees at an average of 20.9 months after pump insertion (P < 0.0001). These 19 patients had a mean rate of change in their Cobb angles of 1.825%/year before pump insertion and 10.95 degrees /year at an average of 23.9 months after pump insertion (P = 0.024). These results represent a 6-fold increase in the curve progression rate after pump insertion. There was no association between catheter tip location or rate of Baclofen infusion on curve progression. In published data, the rate of progression of scoliosis in skeletally immature nonambulatory patients with cerebral palsy was 4.5 degrees /year. In this study, the average rate of progression of the scoliosis for the immature was 9.02 degrees /year. For the skeletally mature bed-ridden patients, the worst-case natural history progression was 4.4 degrees /year. The comparable rate of change in skeletally mature (Risser 5) nonambulatory patients (n = 6) in this study was 28.4 degrees /year. This study demonstrates a significant increase in the rate of scoliotic curve progression after ITB pump placement when compared with published natural history data. The evidence of the beneficial effects of ITB on spasticity has been confirmed, and as larger, prospective randomized studies are conducted, the authors think that support for continued use of this treatment will increase. However, early bracing and spinal fusion may be warranted to prevent significant increases in spinal deformity if scoliosis is anticipated to progress more than 10 degrees /yr for patients with spastic quadriplegia and ITB pump. The authors are now performing spinal fusions for curves that exceed 40 degrees to 50 degrees in the presence of an ITB pump as recommended by previous reviews of scoliosis and accompanying quadriplegia.

Administrator's Handbook for Elementary, Middle, Junior High and High Schools. Regulations and Criteria for Accrediting and Improving the Schools of Oklahoma. Bulletin No. 113-Y.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Education, Oklahoma City. Div. of Instruction.

This administrator handbook begins with statements summarizing Oklahoma's Division of Instruction and the guiding principles of education at the state's elementary and secondary levels. Following an outline of State Board of Education policies, the handbook lists various general regulations and progress criteria for the state as a whole.…

The Test of Our Progress: The Clinton Record on Civil Rights. Report of the Citizens' Commission on Civil Rights.

ERIC Educational Resources Information Center

Yu, Corinne M., Ed.; Taylor, William L., Ed.

The first part of this report consists of the findings of the Citizens' Commission on Civil Rights on the record of the Clinton administration on civil rights. Six years into President Clinton's term, he continues to speak with understanding and empathy about the plight of people trapped in racial and ethnic isolation, but his administration has…

Pre- and postnatal toxicity induced in guinea pigs by N-nitrosomethylurea.

PubMed

Hasumi, K; Wilber, J H; Berkowitz, J; Wilber, R G; Epstein, S S

1975-10-01

Oral administration of N-nitrosomethylurea at maximally tolerated doses to guinea pigs on alternate days from days 34-58 of pregnancy induced prenatal toxicity, as evidenced by a high frequency of stillbirths and intrauterine growth retardation, and postnatal toxicity, as evidenced by stunting and progressive mortality. Similar administration of N-nitrosomethylurethane at maximally tolerated doses did not induce such toxic effects.

U.S. Foreign Aid to the Palestinians

DTIC Science & Technology

2010-01-08

change its stance toward Israel. Even if the immediate objectives of U.S. assistance programs for the Palestinians are met, lack of progress toward a...Chicago Tribune, November 16, 2007. In February 2008, then-USAID Administrator and Director of U.S. Foreign Assistance Henrietta Fore said, in...was encouraging the adoption of more rigorous vetting measures. Testimony of Henrietta Fore, USAID Administrator and Director of U.S. Foreign

To Climb or Not to Climb: The Probing of Self-Imposed Barriers that Delay or Deny Career Aspirations to be an Administrator in a Public School System

ERIC Educational Resources Information Center

McGee, Janet M.

2010-01-01

Throughout history, women have faced numerous career barriers. Although significant progress has made it possible to break through the "glass ceiling," there remains a disproportionate percentage of women at the higher educational administrative positions, specifically the superintendent and high school principal roles. This study will…

Chronic Δ9-Tetrahydrocannabinol Administration May Not Attenuate Simian Immunodeficiency Virus Disease Progression in Female Rhesus Macaques

PubMed Central

Amedee, Angela M.; Nichols, Whitney A.; LeCapitaine, Nicole J.; Stouwe, Curtis Vande; Birke, Leslie L.; Lacour, Nedra; Winsauer, Peter J.

2014-01-01

Abstract Persons living with HIV/AIDS (PLWHA) frequently use cannabinoids, either recreationally by smoking marijuana or therapeutically (delta-9-tetrahydrocannabinol; Δ9-THC dronabinol). Previously, we demonstrated that chronic Δ9-THC administration decreases early mortality in male simian immunodeficiency virus (SIV)-infected macaques. In this study, we sought to examine whether similar protective effects resulted from chronic cannabinoid administration in SIV-infected female rhesus macaques. Clinical and viral parameters were evaluated in eight female rhesus macaques that received either Δ9-THC (0.18–0.32 mg/kg, intramuscularly, twice daily) or vehicle (VEH) starting 28 days prior to intravenous inoculation with SIVmac251. SIV disease progression was assessed by changes in body weight, mortality, viral levels in plasma and mucosal sites, and lymphocyte subsets. In contrast to our results in male animals, chronic Δ9-THC did not protect SIV-infected female rhesus macaques from early mortality. Markers of SIV disease, including viral load and CD4+/CD8+ ratio, were not altered by Δ9-THC compared to control females; however, females that received chronic Δ9-THC did not gain as much weight as control animals. In addition, Δ9-THC administration increased total CXCR4 expression in both peripheral and duodenal CD4+ and CD8+ T lymphocytes prior to SIV inoculation. Although protection from early mortality was not evident, chronic Δ9-THC did not affect clinical markers of SIV disease progression. The contrasting effects of chronic Δ9-THC in males versus females remain to be explained, but highlight the need for further studies to explore the sex-dependent effects of Δ9-THC and other cannabinoids on the HIV disease course and their implications for virus transmission. PMID:25113915

Home administration of maintenance pemetrexed for patients with advanced non-squamous non-small cell lung cancer: rationale, practicalities and phase II feasibility study design

PubMed Central

2013-01-01

Background Home-based care in oncology is mainly reserved for patients at the end of life. Regulations regarding home delivery of cytotoxics differ across Europe, with a notable lack of practice guidelines in most countries. This has led to a lack of data addressing the feasibility of home-based administration of cytotoxic chemotherapy. In advanced non-squamous non-small cell lung cancer, pemetrexed is approved as maintenance therapy after first-line chemotherapy. In this setting, patients have the potential to be treated long-term with maintenance therapy, which, in the absence of unacceptable toxicity, is continued until disease progression. The favourable safety profile of pemetrexed and the ease of its administration by 10-minute intravenous infusion every 3 weeks make this drug a suitable candidate for administration in a home setting. Methods Literature and regulations relevant to the home-based delivery of cytotoxic therapy were reviewed, and a phase II feasibility study of home administration of pemetrexed maintenance therapy was designed. At least 50 patients with advanced non-squamous non-small cell lung cancer, Eastern Cooperative Oncology Group performance status 0–1 and no progressive disease after four cycles of platinum-based first-line therapy are required to allow investigation of the feasibility of home-based administration of pemetrexed maintenance therapy (500 mg/m2 every 3 weeks until progressive disease or unacceptable toxicity). Feasibility is being assessed as adherence to the home-based administration process (primary endpoint), patient safety, impact on patients’ quality of life, patient and physician satisfaction with home care, and healthcare resource use and costs. Enrolment of patients from the UK and Sweden, where home-based care is relatively well developed, commenced in December 2011. Discussion This feasibility study addresses an important aspect of maintenance therapy, that is, patient comfort during protracted home-based chemotherapy. The study design requires unusual methodology and specific logistics to address outcomes relevant to the home-delivery approach. This article presents a study design that offers a novel and reproducible model for home-based chemotherapy, and provides an up-to-date overview of the literature regarding this type of treatment. Trial registration ClinicalTrials.gov: NCT01473563 PMID:24090033

ANNUAL REPORT, JULY 1, 1957

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1958-10-31

The progress and trends of research are presented along with a description of operational, service, end administrative activities. Some scientific and technical details are given on research programs in the physical sciences, life sciences, and engineering, however, more complete technical information is available in quarterly progress reports, BNL technical reports, and scientific and technical periodicals. A bibliography of these publications is appended. (For preceding period see BNL-426.) (D.E.B.)

The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats.

PubMed

Toalston, Jamie E; Deehan, Gerald A; Hauser, Sheketha R; Engleman, Eric A; Bell, Richard L; Murphy, James M; McBride, William J; Rodd, Zachary A

2015-08-01

Alcohol drinking during adolescence is associated in adulthood with heavier alcohol drinking and an increased rate of alcohol dependence. Past research in our laboratory has indicated that peri-adolescent ethanol consumption can enhance the acquisition and reduce the rate of extinction of ethanol self-administration in adulthood. Caveats of the past research include reinforcer specificity, increased oral consumption during peri-adolescence, and a lack of quantitative assessment of the reinforcing properties of ethanol. The current experiments were designed to determine the effects of peri-adolescent ethanol or saccharin drinking on acquisition and extinction of oral ethanol self-administration and ethanol seeking, and to quantitatively assess the reinforcing properties of ethanol (progressive ratio). Ethanol or saccharin access by alcohol-preferring (P) rats occurred during postnatal day (PND) 30-60. Animals began operant self-administration of ethanol or saccharin after PND 85. After 10 weeks of daily operant self-administration, rats were tested in a progressive ratio paradigm. Two weeks later, self-administration was extinguished in all rats. Peri-adolescent ethanol consumption specifically enhanced the acquisition of ethanol self-administration, reduced the rate of extinction for ethanol self-administration, and quantitatively increased the reinforcing properties of ethanol during adulthood. Peri-adolescent saccharin consumption was without effect. The data indicate that ethanol consumption during peri-adolescence results in neuroadaptations that may specifically enhance the reinforcing properties of ethanol during adulthood. This increase in the reinforcing properties of ethanol could be a part of biological sequelae that are the basis for the effects of adolescent alcohol consumption on the increase in the rate of alcoholism during adulthood. Published by Elsevier Inc.

High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats.

PubMed

Cornish, Jennifer L; Clemens, Kelly J; Thompson, Murray R; Callaghan, Paul D; Dawson, Bronwyn; McGregor, Iain S

2008-01-01

Methamphetamine is a drug that is often consumed at dance parties or nightclubs where the ambient temperature is high. The present study determined whether such high ambient temperatures alter intravenous methamphetamine self-administration in the rat. Male Hooded Wistar rats were trained to self-administer intravenous methamphetamine (0.1 mg/kg/infusion) under a fixed ratio 1 (FR1) or progressive ratio (PR) schedule of reinforcement at an ambient temperature of 23 +/- 1 degrees C. They were then given their daily self-administration session at a raised ambient temperature of 30 +/- 1 degrees C. Methamphetamine self-administration was increased at 30 degrees C under both FR1 and PR reinforcement schedules, with the latter effect indicating that heat enhances the motivation to obtain methamphetamine. High temperatures did not alter self-administration of the D1 receptor agonist SKF 82958 in methamphetamine-experienced rats suggesting some specificity in the methamphetamine effect. When rats were given access to drink isotonic saline solution during methamphetamine self-administration sessions they drank much more solution at 30 degrees C than 23 degrees C. However, availability of isotonic saline to drink did not alter the heat-induced facilitation of methamphetamine self-administration (PR schedule) indicating that the heat effect does not simply reflect increased motivation for intravenous fluids. Hyperthermia was evident in rats self-administering methamphetamine at high ambient temperatures and fluid consumption did not prevent this effect. Heat did not affect blood levels of methamphetamine, or its principal metabolite amphetamine indicating that the facilitatory effect of heat did not reflect altered methamphetamine pharmacokinetics. Overall, these results show that high ambient temperatures increase the reinforcing efficacy of methamphetamine and encourage higher levels of drug intake.

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2012 CFR

2012-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2014 CFR

2014-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2011 CFR

2011-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2013 CFR

2013-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

Research progress on disease data bank and DATACON systems

NASA Technical Reports Server (NTRS)

1973-01-01

Developments and specific statistics for this reporting period are presented. The administration, community activities, funding, personnel, marketing and public relations, technical operations, information systems, and technology transfer are discussed.

The Relationship of Role-Based, Task-Based, Boundary-Spanning, and Conflict-Mediating Stress Experienced by New York State Special Education Administrators and Emotional Exhaustion, Depersonalization, and Personal Accomplishment

ERIC Educational Resources Information Center

Ambrosini, MaryAnn

2013-01-01

Given the challenges faced in ensuring the needs of students with disabilities are met in the midst of fiscal constraints, increasing litigation, meeting adequate yearly progress and compliance with State regulations, special education administrators are more at risk for burnout than ever before. Burnout is characterized by a high degree of…

Prenatal and postnatal toxicity induced in guinea-pigs by nitrosomethylurea.

PubMed

Epstein, S S; Hasumi, K; Iobal, Z M

1976-01-01

Oral administration of NMU at maximally tolerated doses of guinea-pigs from day 34 to 58 of pregnancy induced embryotoxic effects, as evidenced by a high incidence of stillbirths and reduction in birth weight, and postnatal toxic effects, as evidenced by stunting, progressive mortality and extensive fatty degeneration of the liver in F1 progeny. Similar administration of NMUT at maximally tolerated doses did not induce such toxic effects.

The New DEEL (Democratic Ethical Educational Leadership) and the Work of Reclaiming a Progressive Alternative in Educational Administration from PreK-20

ERIC Educational Resources Information Center

Gross, Steven Jay; Shapiro, Joan Poliner

2013-01-01

Facing repressive accountability regimes and high-stakes testing in the US and beyond, university and practitioner educators around the world decided to take action. Inspired by the democratic administration movement of the 1930's and 1940's and current scholarship in ethics, we started a movement called the New DEEL (Democratic Ethical…

A Qualitative Exploration of the Experiences through the Labyrinth for Empowered Women Holding Executive Administrative Positions in Land-Grant Doctoral Institutions of Higher Education

ERIC Educational Resources Information Center

Byford, Tina T.

2011-01-01

This research examined the career progression journey of three women who had held executive administrative positions in a land-grant, doctoral institution of higher education. This qualitative study used portraiture, field notes, and document review to examine the career journeys of these three women. The guiding question of the study was, What…

Progressive increase in brain glucose metabolism after intrathecal administration of autologous mesenchymal stromal cells in patients with diffuse axonal injury.

PubMed

Vaquero, Jesús; Zurita, Mercedes; Bonilla, Celia; Fernández, Cecilia; Rubio, Juan J; Mucientes, Jorge; Rodriguez, Begoña; Blanco, Edelio; Donis, Luis

2017-01-01

Cell therapy in neurological disability after traumatic brain injury (TBI) is in its initial clinical stage. We describe our preliminary clinical experience with three patients with diffuse axonal injury (DAI) who were treated with intrathecal administration of autologous mesenchymal stromal cells (MSCs). Three patients with established neurological sequelae due to DAI received intrathecally autologous MSCs. The total number of MSCs administered was 60 × 10 6 (one patient), 100 × 10 6 (one patient) and 300 × 10 6 (one patient). All three patients showed improvement after cell therapy, and subsequent studies with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) showed a diffuse and progressive increase in brain glucose metabolism. Our present results suggest benefit of intrathecal administration of MSCs in patients with DAI, as well as a relationship between this type of treatment and increase in brain glucose metabolism. These preliminary findings raise the question of convenience of assessing the potential benefit of intrathecal administration of MSCs for brain diseases in which a decrease in glucose metabolism represents a crucial pathophysiological finding, such as Alzheimer's disease (AD) and other dementias. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Education and career progression of imaging administrators.

PubMed

South-Winter, Carole

2014-01-01

The advancement into leadership positions for many administrators began as staff technologists moving up via interim management opportunities. New managers must develop supervisory skills while simultaneously assuming responsibility for the operation of the department. Mobility today is based primarily on a formal educational background. A transferable set of skills must be augmented with higher education. Those in the imaging sciences realize that an administrative position requires business and management acumen as well as technical skills. A shortage of imaging administrators is predicted due to an aging population and the rapid advancement of technology in healthcare. Institutes of higher education need to address and support the curricula and programs needed, which includes the CRA credential, for this growing field.

Global Occurrence and Emission of Rotaviruses to Surface Waters

PubMed Central

Kiulia, Nicholas M.; Hofstra, Nynke; Vermeulen, Lucie C.; Obara, Maureen A.; Medema, Gertjan; Rose, Joan B.

2015-01-01

Group A rotaviruses (RV) are the major cause of acute gastroenteritis in infants and young children globally. Waterborne transmission of RV and the presence of RV in water sources are of major public health importance. In this paper, we present the Global Waterborne Pathogen model for RV (GloWPa-Rota model) to estimate the global distribution of RV emissions to surface water. To our knowledge, this is the first model to do so. We review the literature to estimate three RV specific variables for the model: incidence, excretion rate and removal during wastewater treatment. We estimate total global RV emissions to be 2 × 1018 viral particles/grid/year, of which 87% is produced by the urban population. Hotspot regions with high RV emissions are urban areas in densely populated parts of the world, such as Bangladesh and Nigeria, while low emissions are found in rural areas in North Russia and the Australian desert. Even for industrialized regions with high population density and without tertiary treatment, such as the UK, substantial emissions are estimated. Modeling exercises like the one presented in this paper provide unique opportunities to further study these emissions to surface water, their sources and scenarios for improved management. PMID:25984911

The 5/95 gap in the indexation of psychiatric journals of low- and middle-income countries

PubMed Central

Mari, J J; Patel, V; Kieling, C; Razzouk, D; Tyrer, P; Herrman, H

2010-01-01

Mari JJ, Patel V, Kieling C, Razzouk D, Tyrer P, Herrman H. The 5/95 gap in the indexation of psychiatric journals of low- and middle-income countries. Objective: To investigate the relationship between science production and the indexation level of low- and middle-income countries (LAMIC) journals in international databases. Method: Indicators of productivity in research were based on the number of articles produced over the 1994–2004 period. A survey in both Medline and ISI/Thomson was conducted to identify journals according to their country of origin. A WPA Task Force designed a collaborative process to assess distribution and quality of non-indexed LAMIC journals. Results: Twenty LAMIC were found to present more than 100 publications and a total of 222 indexed psychiatric journals were found, but only nine were from LAMIC. The Task Force received 26 questionnaires from editors of non-indexed journals, and concluded that five journals would meet criteria for indexation. Conclusion: Barriers to indexation of journals contribute to the difficulties in achieving fair representation in the main literature databases for the scientific production in these countries. PMID:19764927

Implementing local projects to reduce the stigma of mental illness.

PubMed

Warner, Richard

2008-01-01

This editorial describes strategies used and the lessons learned in implementing two local anti-stigma projects. The WPA Programme to Reduce Stigma and Discrimination Because of Schizophrenia established projects to fight stigma in 20 countries, using social-marketing techniques to enhance their effectiveness. First steps at each site were to establish an action committee and conduct a survey of perceived stigma. Based on survey results, the action committees selected a few homogeneous and accessible target groups, such as employers, and criminal justice personnel. Messages and media were selected, tested, and refined. Guidelines are provided for setting up a consumer (service-user) speakers' bureau and for establishing a media-watch organization, which can lobby news and entertainment media to exclude negative portrayals of people with mental illness. Improvements in knowledge about mental illness were effected in high school students and criminal justice personnel. Positive changes in attitude towards people with mental illness were achieved with high school students, but were more difficult to achieve with police officers. Local antistigma projects can be effective in reducing stigma and relatively inexpensive. The involvement of consumers is important in working with police officers. Project organizers should be on the lookout for useful changes that can become permanent.

The Usher's Syndrome Adolescent: Programming Implications for School Administrators, Teachers, and Residential Advisors.

ERIC Educational Resources Information Center

Hicks, Wanda M.; Hicks, Doin E.

1981-01-01

The article examines educational programing implications for adolescents with Usher's syndrome, a condition of congenital deafness accompanied by progressive loss of vision through retinitis pigmentosa. (DB)

The Comprehensive, Powerful, Academic Database (CPAD): An Evaluative Study of a Predictive Tool Designed for Elementary School Personnel in Identifying At-Risk Students through Progress, Curriculum, and Performance Monitoring

ERIC Educational Resources Information Center

Chavez-Gibson, Sarah

2013-01-01

The purpose of this study is to exam in-depth, the Comprehensive, Powerful, Academic Database (CPAD), a data decision-making tool that determines and identifies students at-risk of dropping out of school, and how the CPAD assists administrators and teachers at an elementary campus to monitor progress, curriculum, and performance to improve student…

US Army Institute of Surgical Research Annual Research Progress Report for Fiscal Year 1984.

DTIC Science & Technology

1984-10-01

the product of the individual and collaborative scientific activities of the Institute’s professionals made possible by the efforts of all members... activities on the process of medical research with the resultant blurring of the distinction between the process and the product. Extensive administrative...professional activities , regulate human studies, and restrict the use of animals in research, but to what effect? Benefits of such administrative

EPA's Administration of the Asbestos in Schools Program. Hearing before the Environment, Energy, and Natural Resources Subcommittee of the Committee on Government Operations. House of Representatives, One Hundred Second Congress, First Session (September 24, 1991).

ERIC Educational Resources Information Center

Congress of the U. S., Washington, DC. House Committee on Government Operations.

Proceedings of a hearing concerning the Environmental Protection Agency's (EPA's) administration of the Asbestos in School Program are presented in this report. Specifically, the hearing's purpose was to examine the EPA's progress in implementing the Asbestos Hazardous Emergency Response Act (AHERA), wherein the agency was responsible for…

FDA advisory committees meet January 26 on Salk HIV-1 immunogen.

PubMed

1995-01-06

Two advisory committees of the Food and Drug Administration (FDA) will meet to consider future trials of the HIV-1 immunogen developed by Dr. Jonas Salk. The Immune Response Corporation has already conducted several studies of the immunogen, and has found improvement in various immunological and other blood tests, and no adverse effects. However, the studies have not been large enough to show conclusively that the treatment has clinical benefit in delaying disease progression. The new, larger trials are intended to demonstrate a delay in disease progression and validate the use of blood-test markers of disease progression for studying an immune-based treatment.

Contractors Road Heavy Equipment Area SWMU 055 Corrective Measures Implementation Progress Report

NASA Technical Reports Server (NTRS)

Dorman, Lane

2015-01-01

This Corrective Measures Implementation (CMI) Progress Report, Revision 1, for Contractor's Road Heavy Equipment (CRHE) Area Solid Waste Management Unit (SWMU) Number 055 was prepared by Geosyntec Consultants (Geosyntec) for the National Aeronautics and Space Administration (NASA) under contract number NNK09CA02B, Delivery Order NNK09CA62D and Project Number PCN ENV-2324. This CMI Progress Report documents: (i) activities conducted as part of supplemental assessment activities completed from June 2009 through November 2014; (ii) Engineering Evaluation (EE) Advanced Data Packages (ADPs); and (iii) recommendations for future activities related to corrective measures at the Site.

A Comparison of Nurses’ Activities Under Two Models of Administration

DTIC Science & Technology

1985-08-01

Angela Sheehan, "Innovation in Cancer Nursing and the Role of the Nurse in Clinical Trials," Progress in Clinical and Biological Research 121 (1983): 87...by Diagnosis-Related Groups,* Annals of Internal Medicine 100 (April 1984): 576. 12Tony DeCrosta, " Megatrends in Nursing: 10 New Directions that are...in Clinical Trials." Progress in Clinical and Biological Research 121 (1983): 87-92. Beyers, Marjorie: Byre, Calvin: Levy, Paul: Mallin, Katherine

The medical care system of Hungary.

PubMed

Raffel, N K; Raffel, M W

1988-01-01

Medical care in Hungary has made significant progress since World War II in spite of other social priorities which have limited financial support of the health system. A shortage of hard currency in a high technological era is now having a particularly severe adverse impact on further development. Decentralized administration and local finance have, however, provided some room for progress. Preventive efforts are hampered by a deeply entrenched life style which is not conducive to improving the population's health status.

Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Hui-fang; Takaoka, Munenori; Bao, Xiao-hong

2012-07-13

Highlights: Black-Right-Pointing-Pointer A novel FAK inhibitor TAE226 suppressed FAK activity in HCT116 colon cancer cells. Black-Right-Pointing-Pointer TAE226 suppressed proliferation and migration, with a modest effect on adhesion. Black-Right-Pointing-Pointer Silencing of FAK by siRNA made no obvious difference on cancer cell attachment. Black-Right-Pointing-Pointer TAE226 treatment suppressed the progression of peritoneal dissemination. Black-Right-Pointing-Pointer Oral administration of TAE226 prolonged the survival of tumor-bearing mice. -- Abstract: Peritoneal dissemination is one of the most terrible types of colorectal cancer progression. Focal adhesion kinase (FAK) plays a crucial role in the biological processes of cancer, such as cell attachment, migration, proliferation and survival, all ofmore » which are essential for the progression of peritoneal dissemination. Since we and other groups have reported that the inhibition of FAK activity exhibited a potent anticancer effect in several cancer models, we hypothesized that TAE226, a novel ATP-competitive tyrosine kinase inhibitor designed to target FAK, can prevent the occurrence and progression of peritoneal dissemination. In vitro, TAE226 greatly inhibited the proliferation and migration of HCT116 colon cancer cells, while their adhesion on the matrix surface was minimally inhibited when FAK activity and expression was suppressed by TAE226 and siRNA. In vivo, when HCT116 cells were intraperitoneally inoculated in mice, the cells could attach to the peritoneum and begin to grow within 24 h regardless of the pretreatment of cells with TAE226 or FAK-siRNA, suggesting that FAK is not essential, at least for the initial integrin-matrix contact. Interestingly, the treatment of mice before and after inoculation significantly suppressed cell attachment to the peritoneum. Furthermore, oral administration of TAE226 greatly reduced the size of disseminated tumors and prolonged survival in tumor-bearing mice. Taken together, a possible strategy for inhibiting peritoneal dissemination by targeting FAK with TAE226 appears to be applicable through anti-proliferative and anti-invasion/anti-migration mechanisms.« less

Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression.

PubMed

Katz, M L; Johnson, G C; Leach, S B; Williamson, B G; Coates, J R; Whiting, R E H; Vansteenkiste, D P; Whitney, M S

2017-04-01

CLN2 neuronal ceroid lipofuscinosis is a hereditary lysosomal storage disease with primarily neurological signs that results from mutations in TPP1, which encodes the lysosomal enzyme tripeptidyl peptidase-1 (TPP1). Studies using a canine model for this disorder demonstrated that delivery of TPP1 enzyme to the cerebrospinal fluid (CSF) by intracerebroventricular administration of an AAV-TPP1 vector resulted in substantial delays in the onset and progression of neurological signs and prolongation of life span. We hypothesized that the treatment may not deliver therapeutic levels of this protein to tissues outside the central nervous system that also require TPP1 for normal lysosomal function. To test this hypothesis, dogs treated with CSF administration of AAV-TPP1 were evaluated for the development of non-neuronal pathology. Affected treated dogs exhibited progressive cardiac pathology reflected by elevated plasma cardiac troponin-1, impaired cardiac function and development of histopathological myocardial lesions. Progressive increases in the plasma activity levels of alanine aminotransferase and creatine kinase indicated development of pathology in the liver and muscles. The treatment also did not prevent disease-related accumulation of lysosomal storage bodies in the heart or liver. These studies indicate that optimal treatment outcomes for CLN2 disease may require delivery of TPP1 systemically as well as directly to the central nervous system.

Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression

PubMed Central

Katz, M L; Johnson, G C; Leach, S B; Williamson, B G; Coates, J R; Whiting, R E H; Vansteenkiste, D P; Whitney, M S

2017-01-01

CLN2 neuronal ceroid lipofuscinosis is a hereditary lysosomal storage disease with primarily neurological signs that results from mutations in TPP1, which encodes the lysosomal enzyme tripeptidyl peptidase-1 (TPP1). Studies using a canine model for this disorder demonstrated that delivery of TPP1 enzyme to the cerebrospinal fluid (CSF) by intracerebroventricular administration of an AAV-TPP1 vector resulted in substantial delays in the onset and progression of neurological signs and prolongation of life span. We hypothesized that the treatment may not deliver therapeutic levels of this protein to tissues outside the central nervous system that also require TPP1 for normal lysosomal function. To test this hypothesis, dogs treated with CSF administration of AAV-TPP1 were evaluated for the development of non-neuronal pathology. Affected treated dogs exhibited progressive cardiac pathology reflected by elevated plasma cardiac troponin-1, impaired cardiac function and development of histopathological myocardial lesions. Progressive increases in the plasma activity levels of alanine aminotransferase and creatine kinase indicated development of pathology in the liver and muscles. The treatment also did not prevent disease-related accumulation of lysosomal storage bodies in the heart or liver. These studies indicate that optimal treatment outcomes for CLN2 disease may require delivery of TPP1 systemically as well as directly to the central nervous system. PMID:28079862

Outcome mapping for fostering and measuring change in risk management behaviour among urban dairy farmers in Nairobi, Kenya.

PubMed

Nyangaga, Julius N; Grace, Delia; Kimani, Violet; Kiragu, Monica W; Langat, Alfred K; Mbugua, Gabriel; Mitoko, Grace; Kang'ethe, Erastus K

2012-09-01

A study was undertaken to investigate and mitigate the risk from zoonotic Cryptosporidium associated with dairy farming in Dagoretti division, Nairobi, Kenya. Outcome mapping (OM), a relatively new tool for planning and evaluation, was used to foster and then monitor changes in farmer management of health risks. Elements of the OM framework, including the vision, mission and expected progress markers, were developed in participatory sessions and a set of progress markers was used for monitoring behaviour change in farmers participating in the project (the boundary partners). Behaviour change (the outcome challenge) was supported by a range of awareness and educational campaigns, working with strategic partners (extension agents and administrative leaders). The farmers the project worked with made considerable progress according to the markers; they demonstrated an understanding of cryptosporidiosis, established or maintained clean and well drained cattle sheds, and took conscious effort to reduce possible infection. Farmers who did not participate in the project (non-contact farmers) were found to be less advanced on the progress marker indicators. Non-contact farmers who carried out risk-reducing practices had done so independently of the project team. The administration leaders, as strategic partners, had a positive attitude towards the project and confidence in their ability to support project objectives. The study demonstrates the utility of OM in helping to identify and support behavioural change.

76 FR 55656 - Notice of Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... Administration (RSA) approval a program improvement plan (PIP) using the on-line form located on the RSA...(c), RSA reviews an agency's progress toward achieving the goals established in the PIP. For this...

76 FR 40984 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

... doeuvres and beverages matching the quality of a 4-Star restaurant. Holiday Events will be highlighted by... processes and marine biology with passengers. A Progressive Waterfront Restaurant Tour with stops at fine...

Quiet Pavement Pilot Program : Progress Report 3

DOT National Transportation Integrated Search

2012-09-01

Since 2003, the Arizona Department of Transportation (ADOT) has been conducting a Quiet Pavement : Pilot Program (QPPP) in cooperation with the Federal Highway Administration (FHWA). This report : presents the noise findings of this research through ...

Progress in rail integrity research

DOT National Transportation Integrated Search

2001-10-01

This report describes the work conducted over the past two decades on rail integrity research sponsored by the Federal Railroad Administration (FRA) and carried out by the Volpe National Transportation Systems Center. The research has involved both e...

Quarterly Progress Report (January 1 to March 31, 1950)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brookhaven National Laboratory

This is the first of a series of Quarterly Reports. These reports will deal primarily with the progress made in our scientific program during a three months period. Those interested in matters pertaining to organization, administration, complete scientific program, personnel and other matters not directly involved in current scientific progress are referred to our Annual Progress Report which is issued in January. We have attempted to describe new information that appears significant, or of interest, to other scientists within the Atomic Energy Commission Laboratories. No effort has been made, however, to detail progress in each and every research project. Littlemore » or no reference will therefore be found to the projects in which progress during the current period is considered too inconclusive. Since our organizational structure is departmental, the work described herein is arranged in the following sequence: (1) Accelerator Project; (2) Biology Department; (3) Chemistry Department; (4) Instrumentation and Health Physic8 Department; (5) Medical Department; (6) Physics Department; and (7) Reactor Science and Engineering Department.« less

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Robert Lightfoot, talks during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Maintenance Management Information and Control System (MMICS). Administrative Boon or Burden.

DTIC Science & Technology

1984-03-01

training schools (fundamentals and theory ) for the particular career field; through correspondence courses developed and written by the Air Force, and...are identified, scheduled and done on a timely basis. 6 "The administration of an individual’s Upgrade Training ( UGT ) to meet the job knowledge and...formal OJT must study and complete a Career Develop- ment Course (CDC) as part of their upgrade training ( UGT ). The progress and status of the course is

Melatonin Attenuates Memory Impairment, Amyloid-β Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer's Disease.

PubMed

Rudnitskaya, Ekaterina A; Muraleva, Natalia A; Maksimova, Kseniya Yi; Kiseleva, Elena; Kolosova, Nataliya G; Stefanova, Natalia A

2015-01-01

Melatonin is a multifunctional molecule and plays a crucial role in the regulation of circadian rhythms. The role of melatonin in the protection of the central nervous system is well documented. Therefore, melatonin was proposed as a possible therapeutic agent for reducing the severity of Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by cognitive decline and memory dysfunction. Recently, we showed beneficial neuroprotective effects of prophylactic supplementation with melatonin in a suitable model of sporadic AD: OXYS rats, which exhibit disturbances in melatonin secretion. In the present study, we demonstrated that melatonin administration, when started at the age of active progression of AD-like pathology, decreased the amyloid-β1 - 42 and amyloid-β1 - 40 levels in the hippocampus and amyloid-β1 - 42 levels in the frontal cortex of OXYS rats. Furthermore, oral administration of melatonin slowed down degenerative alterations in hippocampal neurons of OXYS rats. The most noticeable improvement was observed in the CA1 region of the hippocampus. Melatonin administration prevented the decrease in the mitochondria-occupied portion of the neuronal volume and improved the ultrastructure of mitochondria in the neurons of the CA1 region. Additionally, melatonin treatment of OXYS rats slowed down an increase in anxiety and deterioration of reference memory. Thus, melatonin administration could alleviate the burden of AD and may be considered a promising pharmaceutical treatment of the disease.

Steps To Beat Stress.

ERIC Educational Resources Information Center

Shelton, Michael

1998-01-01

Explains techniques for reducing stress: diaphragmatic breathing, relaxation, progressive muscle relaxation, and meditation. Two sidebars define the fight-or-flight response and the camp administration's role in helping to lower stress through staff training and reduction of camp-wide stressors. (SAS)

Human Factors in Railroad Operations : Initial Studies

DOT National Transportation Integrated Search

1972-01-01

This report summarizes the progress of a year's work in providing support in human factors to the Federal Railroad Administration. The principal topics include: (a) a description of the locomotive engineer's job, particularly with regard to its inher...

[Immunomodulators of microbial origin enhance cytotoxicity of human mononuclear leukocytes and reduce metastatic progression of Lewis lung carcinoma in mice].

PubMed

Akhmatova, N K; Semenova, I B; Donenko, F V; Kiselevskiĭ, M V; Kurbatova, E A; Egorova, N B

2006-01-01

Effect of immunomodulators for microbial origin on innate immunity and antitumor system was continued to study. Immunomodificator Immunovac VP-4, purified staphylococcal toxoid and glucosaminyl muramyl dipeptide (GMDP) equally enhanced cytotoxicity of mononuclear leukocytes of peripheral blood of healthy donors. Index of cytotoxicity was 2.78, 2.77 and 2.70 respectively. Reduced metastatic progression of Lewis lung carcinoma in mice was observed after Immunovac VP-4 and GMDP administration. Effectiveness was seen when preparations administered according to schedules including their administration before implantation of the tumor. If preparations were administered number of metastases reduced in 4.4-5.6 times and size of metastases reduced in 7-10 times. Interplay between antitumor activity of studied immunomodulators and cytotoxic activity of NK-cells, which are base effectors of antitumor immune response, are discussed.

The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma.

PubMed

McMurphy, Travis; Xiao, Run; Magee, Daniel; Slater, Andrew; Zabeau, Lennart; Tavernier, Jan; Cao, Lei

2014-01-01

Environmental and genetic activation of a brain-adipocyte axis inhibits cancer progression. Leptin is the primary peripheral mediator of this anticancer effect in a mouse model of melanoma. In this study we assessed the effect of a leptin receptor antagonist on melanoma progression. Local administration of a neutralizing nanobody targeting the leptin receptor at low dose adjacent to tumor decreased tumor mass with no effects on body weight or food intake. In contrast, systemic administration of the nanobody failed to suppress tumor growth. Daily intraperitoneal injection of high-dose nanobody led to weight gain, hyperphagia, increased adiposity, hyperleptinemia, and hyperinsulinemia, and central effects mimicking leptin deficiency. The blockade of central actions of leptin by systemic delivery of nanobody may compromise its anticancer effect, underscoring the need to develop peripherally acting leptin antagonists coupled with efficient cancer-targeting delivery.

Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy.

PubMed

Larkindale, Jane; Abresch, Richard; Aviles, Enrique; Bronson, Abby; Chin, Janice; Furlong, Pat; Gordish-Dressman, Heather; Habeeb-Louks, Elizabeth; Henricson, Erik; Kroger, Hans; Lynn, Charles; Lynn, Stephen; Martin, Dana; Nuckolls, Glen; Rooney, William; Romero, Klaus; Sweeney, Lee; Vandenborne, Krista; Walter, Glenn; Wolff, Jodi; Wong, Brenda; McDonald, Craig M; Duchenne Regulatory Science Consortium Imaging-Dmd Consortium And The Cinrg Investigators, Members Of The

2017-01-12

The Duchenne Regulatory Science Consortium (D-RSC) was established to develop tools to accelerate drug development for DMD.  The resulting tools are anticipated to meet validity requirements outlined by qualification/endorsement pathways at both the U.S. Food and Drug Administration (FDA) and European Medicines Administration (EMA), and will be made available to the drug development community. The initial goals of the consortium include the development of a disease progression model, with the goal of creating a model that would be used to forecast changes in clinically meaningful endpoints, which would inform clinical trial protocol development and data analysis.  Methods: In April of 2016 the consortium and other experts met to formulate plans for the development of the model.  Conclusions: Here we report the results of the meeting, and discussion as to the form of the model that we plan to move forward to develop, after input from the regulatory authorities.

Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

PubMed Central

Pekkala, Seija; Wiener, Debra; Himali, Jayandra J.J.; Beiser, Alexa S.; Obler, Loraine K.; Liu, Yulin; McKee, Ann; Auerbach, Sanford; Seshadri, Sudha; Wolf, Philip A.; Au, Rhoda

2014-01-01

We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n = 23) and a comparison group without criteria for AD (n = 24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS), and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7–9 years prior to death and FAS and BNT only at 2–4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD. PMID:23985011

Lexical retrieval in discourse: an early indicator of Alzheimer's dementia.

PubMed

Pekkala, Seija; Wiener, Debra; Himali, Jayandra J; Beiser, Alexa S; Obler, Loraine K; Liu, Yulin; McKee, Ann; Auerbach, Sanford; Seshadri, Sudha; Wolf, Philip A; Au, Rhoda

2013-12-01

We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n = 23) and a comparison group without criteria for AD (n = 24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

Tom Kalil, Deputy Director for Technology and Innovation, White House Office of Science and Technology Policy, and, NASA Deputy Administrator Lori Garver, listen as NASA Associate Administrator for Human Exploration and Operations, William Gerstenmaier, talks during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Evaluation of antivenom therapy for Vipera palaestinae bites in children: experience of two large, tertiary care pediatric hospitals.

PubMed

Pivko-Levy, Dikla; Munchnak, Itamar; Rimon, Ayelet; Balla, Uri; Scolnik, Dennis; Hoyte, Christopher; Voliovitch, Yair; Glatstein, Miguel

2017-04-01

Antivenom has been successfully used to treat systemic and progressive, local manifestations of envenomation inflicted by Vipera (V.) palaestinae, the most common venomous snake in Israel. The objective of this study was to evaluate the fixed dose V. palaestinae monovalent (equine) immunoglobulin G antivenom used in two pediatric emergency departments. In particular, we wanted to assess the need for repeated antivenom administration and the rate of adverse antivenom effects in children. A retrospective chart review was performed for all children admitted with definite or probable signs of V. palaestinae envenomation to Chaim Sheba Medical Center and Kaplan Medical Center between 1 March 2008 and 1 March 2014. Extracted data included: age, location of bite, time to hospital arrival, time to antivenom administration if indicated, outcomes, and complications of the envenomation and adverse effects to the antivenom. 57 patients met inclusion criteria; they ranged from 1 to 17 years in age and median age was 9.5 years. Clinical manifestations were evident in 55 (96.4%) of victims: 18 presented with minimal local signs and 37 showed marked progressive, local features (rapidly progressing edema) and signs of systemic envenomation: tachycardia (20), vomiting (17), abdominal pain (11) and hypotension (6). Two patients developed compartment syndrome and underwent surgical decompression (both received only a loading dose of antivenom with no subsequent maintenance dose). One patient developed thrombocytopenia and three patients presented with mild coagulopathy. Antivenom was administered to 25 (42%) children. Indications for antivenom administration included moderate to severe local signs (19 patients) and systemic signs (6 patients). None of these patients developed adverse reactions, serum sickness, or other side effects to the antivenom. One patient received a single additional 30mL dose of antivenom, due to hypotension and syncope, with good response. In children, 50 ml dosing of V. palaestinae antivenom is efficacious and safe for the treatment of systemic and progressive local manifestations of envenomation by V. palaestinae.

Progress in aeronautical research and technology applicable to civil air transports

NASA Technical Reports Server (NTRS)

Bower, R. E.

1981-01-01

Recent progress in the aeronautical research and technology program being conducted by the United States National Aeronautics and Space Administration is discussed. Emphasis is on computational capability, new testing facilities, drag reduction, turbofan and turboprop propulsion, noise, composite materials, active controls, integrated avionics, cockpit displays, flight management, and operating problems. It is shown that this technology is significantly impacting the efficiency of the new civil air transports. The excitement of emerging research promises even greater benefits to future aircraft developments.

Contrast between Management Information Needs and Information Provided by Industrial Accounting/Control Systems Employed at Selected Coast Guard in House Maintenance Activities.

DTIC Science & Technology

1979-12-01

degree of MASTER OF SCIENCE IN MANAGEMENT from the t NAVAL POSTGRADUATE SCHOOL December 1979 Author 7 tQ . ~ a Approved by...Thesis Advisor Second Reader irman, Department of Administrative Science Deno 7 _a tion and Policy Sciences 3 Roo m ,.WOEP-r1P ABSTRACT This...and Supply Center Work Progress Report #1, Aircraft Rework 41 VIII. Exhibit 2- 7 USCG Aircraft Repair and Supply Center Work Progress Report #5, Direct

Rapidly-progressive catatonia responsive to zolpidem in a patient with ovarian teratoma-associated paraneoplastic encephalitis.

PubMed

Amorim, Edilberto; McDade, Eric M

2016-08-01

Psychiatric symptoms and catatonia are key components of the clinical presentation of paraneoplastic encephalitis; additionally symptoms can be long-lasting and often difficult to treat. We report a 73-year-old patient with rapidly progressive catatonia not responsive to immunotherapy, tumor resection, electroconvulsive therapy, or benzodiazepines who had significant improvement after zolpidem administration. This report suggests that zolpidem is an option in the treatment of patients with refractory catatonia and paraneoplastic encephalitis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Administrative compensation of medical injuries: a hardy perennial blooms again.

PubMed

Barringer, Paul J; Studdert, David M; Kachalia, Allen B; Mello, Michelle M

2008-08-01

Periods in which the costs of personal injury litigation and liability insurance have risen dramatically have often provoked calls for reform of the tort system, and medical malpractice is no exception. One proposal for fundamental reform made during several of these volatile periods has been to relocate personal injury disputes from the tort system to an alternative, administrative forum. In the medical injury realm, a leading incarnation of such proposals in recent years has been the idea of establishing specialized administrative "health courts." Despite considerable stakeholder and policy-maker interest, administrative compensation proposals have tended to struggle for broad political acceptance. In this article, we consider the historical experience of administrative medical injury compensation proposals, particularly in light of comparative examples in the context of workplace injuries, automobile injuries, and vaccine injuries. We conclude by examining conditions that may facilitate or impede progress toward establishing demonstration projects of health courts.

29 CFR 1960.71 - Agency annual reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... individual agency progress and problems in correcting unsafe or unhealthful working conditions, and... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) BASIC PROGRAM ELEMENTS FOR FEDERAL EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED...

29 CFR 1960.78 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency progress and problems in correcting unsafe and unhealthful working conditions, and recommendations... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) BASIC PROGRAM ELEMENTS FOR FEDERAL EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED...

FHWA Traffic Noise Model (TNM) pavement effects implementation study : progress report 1

DOT National Transportation Integrated Search

2012-01-31

The Volpe Center Acoustics Facility, in support of the Federal Highway Administration (FHWA), investigated the implementation of pavement effects in the FHWA Traffic Noise Model (TNM). Three options were considered, resulting in the recommendation of...

Connecting Learners: The South Carolina Educational Technology Plan.

ERIC Educational Resources Information Center

South Carolina State Dept. of Education, Columbia.

This educational technology plan for South Carolina contains the following sections: (1) statewide progress related to the telecommunications infrastructure, professional development, video infrastructure, administrative infrastructure, and funding; (2) introduction to educational technology concepts, including major components and factors…

On DWI laws in other countries

DOT National Transportation Integrated Search

2000-03-01

Much of the progress that has been made in impaired driving in the last decade or more has been facilitated by lessons learned from other countries. It is therefore both timely and appropriate for the National Highway Traffic Safety Administration to...

20 CFR 638.522 - Evaluation of student progress.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 638.522 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.522 Evaluation of... issued by the Job Corps Director. ...

48 CFR 242.7502 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 242.7502 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Accounting Systems and...-materials, or labor-hour contracts, or contracts which provide for progress payments based on costs or on a...

48 CFR 242.7502 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 242.7502 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Accounting Systems and...-materials, or labor-hour contracts, or contracts which provide for progress payments based on costs or on a...

48 CFR 242.7502 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 242.7502 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Accounting Systems and...-materials, or labor-hour contracts, or contracts which provide for progress payments based on costs or on a...

48 CFR 242.7502 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 242.7502 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Accounting Systems and...-materials, or labor-hour contracts, or contracts which provide for progress payments based on costs or on a...

Progression of Human Factors Considerations for the In-Trail Procedure

DOT National Transportation Integrated Search

2016-03-16

The In-Trail Procedure (ITP) is one of the Automatic Dependent Surveillance-Broadcast (ADS-B) applications in the NextGen program. The Federal Aviation Administration, in partnership with United Airlines, is conducting an operational evaluation of th...

National Aeronautics and Space Administration Science and Engineering Apprentice Program

NASA Technical Reports Server (NTRS)

1997-01-01

The National Aeronautics and Space Administration's Science and Engineering Apprentice Program for high school students is one of NASA's many efforts toward a goal of scientific literacy. It embraces science, mathematics, and technology as keys to purposeful and sustained progress and security for our nation and its people. It serves as a model for helping reform education by striving to address mechanisms to influence the knowledge, skills, and attitudes of our students. It focuses on what to do today to meet the challenges of tomorrow.

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator for Human Exploration and Operations, William Gerstenmaier, talks during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Science John Grunsfeld, Ph.D, talks during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator for Space Technology, Mike Gazarik, Ph.D, talks during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator Robert Lightfoot, listens as other NASA senior leadership talk during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

White grain mycetoma caused by Scedosporium apiospermum in North India: a case report.

PubMed

Gupta, Munesh Kumar; Banerjee, Tuhina; Kumar, Dhirendra; Rastogi, Amit; Tilak, Ragini

2013-12-01

Mycetoma is chronic granulomatous infection of skin and subcutaneous tissue caused by both bacteria and fungi. We report a case of mycetoma caused by Scedosporium apiospermum in the right foot of a 45-year-old farmer in north India. The patient had a history of trauma in the sole of the right foot followed by discharge of white granules along with proximal progression. Scedosporium apiospermum was identified based on colony characteristics and microscopic features on slide culture. Mycetoma is a progressive disease. Foot is commonly affected in persons who walk barefoot, especially in south India. Untreated mycetoma progress and involve the underlying fasciae and tissues along with bones often resulting in loss of limb. By prompt and reliable diagnosis with corresponding antimicrobial administration, we can prevent further progression and limb disability.

Influence of acute and chronic administration of methadone hydrochloride on NADPH-cytochrome c reductase and cytochrome P-450 of mouse liver microsomes.

PubMed

Datta, R K; Johnson, E A; Bhattacharjee, G; Stenger, R J

1976-03-01

Administration of a single acute dose (20 mg/kg body weight) of methadone hydrochloride to both male and female mice increased the specific activity of NADPH-cytochrome c reductase and did not change much the content of cytochrome P-450 of their liver microsomes. Administration of multiple acute doses of methadone in male mice increased the specific activity of cytochrome c reductase and the content of cytochrome P-450 of their liver microsomes. Chronic administration of progressively increasing doses of methadone (up to 40 mg/kg body weight) to male mice increased the specific activity of c reductase. Similar chronic administration of methadone up to 28 mg/kg body weight also increased the microsomal content of P-450, but with higher doses of methadone, the content of P-450 declined and finally dropped slightly below control levels. The levels of c reductase activity and P-450 content returned to normal about two weeks after discontinuation of methadone administration.

Administration of angiotensin-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients.

PubMed

Wakabayashi, Kana; Tsujino, Takeshi; Naito, Yoshiro; Ezumi, Akira; Lee-Kawabata, Masaaki; Nakao, Shinji; Goda, Akiko; Sakata, Yasushi; Yamamoto, Kazuhiro; Daimon, Takashi; Masuyama, Tohru

2011-05-01

It is almost unknown which demographic factors or medications affect the progression of aortic stenosis (AS) in Japanese patients with mild AS. We identified a total of 194 patients with native tricuspid valvular AS, defined as a continuous-wave Doppler determined peak aortic valve jet velocity of ≥ 2.0 m/s, in whom echo Doppler studies were repeated at an interim of at least 6 months. Annualized change in peak jet velocity was calculated, and effects of age, sex, diabetes mellitus, blood pressure, serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels, and use of statins and antihypertensive agents on the progression of AS were retrospectively evaluated. Peak aortic valve jet velocity was 2.36 ± 0.79 m/s (mean ± SD) and annualized increase in peak aortic valve jet velocity was 0.17 ± 0.32 m/s/year for all the studied patients. The increase in peak aortic valve jet velocity was lower in patients taking angiotensin-converting enzyme inhibitors (ACE-Is) than in those not taking ACE-Is (0.04 ± 0.22 vs. 0.20 ± 0.32 m/s/year, P < 0.05). Such protective associations were not observed for other first-line antihypertensive agents and statins. Multiple linear regression analysis revealed that ACE-I treatment, decrease in left ventricular ejection fraction, and higher peak aortic valve jet velocity at the first echocardiogram were associated with slower progression of AS. Administration of ACE-Is was associated with the slow progression of mild AS in Japanese patients. Prospective study to assess this hypothesis is needed.

Preparations for Meeting New York and Connecticut MTBE Bans

EIA Publications

2003-01-01

In response to a Congressional request, the Energy Information Administration examined the progress being made to meet the bans on the use of methyl tertiary butyl ether (MTBE) being implemented in New York and Connecticut at the end of 2003.

Nonmotorized transportation pilot program : continued progress in developing walking and bicycling networks - May 2014

DOT National Transportation Integrated Search

2014-05-01

In 2005, the United States Congress directed the Federal Highway Administration (FHWA) to develop the Nonmotorized Transportation Pilot Program (NTPP). The program provided over $25 million in contract authority to four pilot communities (Columbia, M...

Successful School Downsizing.

ERIC Educational Resources Information Center

Raywid, Mary Anne

1997-01-01

Solid research evidence links smaller schools to fewer discipline problems, lower dropout rates, higher student participation levels, and steadier academic progress. Large buildings are no obstacle. Creating small schools requires top administrators to lend impetus and support, facilitate teacher volunteer groups, develop clear policies, adjust…

29 CFR 1926.600 - Equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Motor Vehicles, Mechanized Equipment, and Marine..., adjacent to a highway in normal use, or adjacent to construction areas where work is in progress, shall...

ARC-1998-A98-0242-1

NASA Image and Video Library

1998-11-24

NASA Administrators Award for: 1. 'Turning Goals into Reality' presented to Center TRACON Automation System Team, Langley Research Center October 9, 1998 2. 'Turning Goals into Reality 1998 Goal Award for Excetptional Progress toward Next-Generation Design Tools and Experimental Aircraft acrylic

Let's Not Be Shy about Marketing.

ERIC Educational Resources Information Center

Trachtenberg, Stephen Joel

1984-01-01

Attitudes about college marketing have hindered its progress. It is an informative process with strong feedback, including such elements as information gathering, travel, development of a marketing or public relations plan, organizational communication, institutional adaptation to the current market, and administrator input. (MSE)

ANNUAL REPORT, JULY 1, 1960

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1961-10-31

Research facilities, general construction progress, research activities, and administration are discussed and a financial statement is given. Fairly detailed accounts are given of research programs in the fields of physics, accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medicine. (M.C.G.)

Aviation--An Individualized Approach

ERIC Educational Resources Information Center

Seeds, Fred F.

1974-01-01

Describes an individualized aviation course for high school seniors. The course, broken down into Learner Education Guides with students progressing at their own learning rates, consists of the history of aviation, career opportunities, the space program, basic aeronautics, navigation, meteorology, Federal Aviation Administration regulations and…

3 CFR 9066 - Proclamation 9066 of December 2, 2013. International Day of Persons With Disabilities, 2013

Code of Federal Regulations, 2014 CFR

2014-01-01

... disabilities—including our 5.5 million disabled veterans—to work, study, and travel abroad. My Administration... Persons with Disabilities, we celebrate the enormous progress made at home and abroad and we strengthen...

[Bavarian mental health reform 1851. An instrument of administrative modernization].

PubMed

Burgmair, Wolfgang; Weber, Matthias M

2008-01-01

By 1850 the reformation of institutional psychiatric care in Bavaria was given the highest priority by monarchy and administration. Cooperating with experts, especially the psychiatrist Karl August von Solbrig, they provided for new asylums to be established throughout Bavaria in a surprisingly short period of time. It was, however, only at personal intervention of King Max II. that the administrative and financial difficulties which had existed since the beginning of the 19th century could be overcome. The planning of asylums done by each administrative district of Bavaria vividly reflects rivalry as well as cooperation between all governmental and professional agencies involved. Modernization of psychiatry was publicly justified by referring to scientism, the need for a more progressive restructuring of administration, and the paternalistic care of the monarchy, whereas, from an administrative point of view, aspects of psychiatric treatment, like what kind of asylum would be best, were rather insignificant. The structures established by means of the alliance between state administration and psychiatric care under the rule of King Max II. had a lasting effect on the further development of Bavaria.

Chemical Characterization and Identification of Organosilicon Contaminants in ISS Potable Water

NASA Technical Reports Server (NTRS)

Straub, John E., II; Plumlee, Debrah K.; Gazda, Daniel B.

2016-01-01

2015 marked the 15th anniversary of continuous human presence on board the International Space Station. During the past year crew members from Expeditions 42-46, including two participating in a one-year mission, continued to rely on reclaimed water as their primary source of potable water. This paper presents and discusses results from chemical analyses performed on ISS water samples returned in 2015. Since the U.S. water processor assembly (WPA) became operational in 2008, there have been 5 instances of organic contaminants breaking through the treatment process. On each occasion, the breakthrough was signaled by an increase in the total organic carbon (TOC) concentration in the product water measured by the onboard TOC analyzer (TOCA). Although the most recent TOC rise in 2015 was not unexpected, it was the first time where dimethylsilanediol (DMSD) was not the primary compound responsible for the increase. Results from ground analysis of a product water sample collected in June of 2015 and returned on Soyuz 41 showed that DMSD only accounted for 10% of the measured TOC. After considerable laboratory investigation, the compound responsible for the majority of the TOC was identified as monomethysilanetriol (MMST). MMST is a low-toxicity compound that is structurally similar to DMSD.

Environmental Control and Life Support Integration Strategy for 6-Crew Operations Stephanie Duchesne

NASA Technical Reports Server (NTRS)

Duchesne, Stephanie M.

2009-01-01

The International Space Station (ISS) crew compliment has increased in size from 3 to 6 crew members . In order to support this increase in crew on ISS, the United States on-orbit Segment (USOS) has been outfitted with a suite of regenerative Environmental Control and Life Support (ECLS) hardware including an Oxygen Generation System(OGS), Waste and Hygiene Compartment (WHC), and a Water Recovery System (WRS). The WRS includes the Urine Processor Assembly (UPA) and the Water Processor Assembly (WPA). With this additional life support hardware, the ISS has achieved full redundancy in its on-orbit life support system between the USOS and Russian Segment (RS). The additional redundancy created by the Regenerative ECLS hardware creates the opportunity for independent support capabilities between segments, and for the first time since the start of ISS, the necessity to revise Life Support strategy agreements. Independent operating strategies coupled with the loss of the Space Shuttle supply and return capabilities in 2010 offer new and unique challenges. This paper will discuss the evolution of the ISS Life Support hardware strategy in support of 6-Crew on ISS, as well as the continued work that is necessary to ensure the support of crew and ISS Program objectives through the life of station.

Clean Water for Remote Locations

NASA Technical Reports Server (NTRS)

2006-01-01

Marshall Space Flight Center engineers are working on creating the Regenerative Environmental Control and Life Support System, a complex system of devices intended to sustain the astronauts living on the ISS and, in the future, sustain those who are blasting off to the Moon or Mars. The devices make use of the available resources, by turning wastewater from respiration, sweat, and urine into drinkable water. One of the devices that Marshall has been working on is the Water Recovery System (WRS). Marshall has teamed with long-time NASA contractor, Hamilton Sundstrand Space Systems International, Inc., of Windsor Locks, Connecticut. Hamilton Sundstrand, the original designer of the life support devices for the space suits, developed the Water Processor Assembly (WPA). It, along with the Urine Processor Assembly (UPA) developed by Marshall, combines to make up the total system, which is about the size of two refrigerators, and will support up to a six-member crew. The system is currently undergoing final testing and verification. "The Water Processor Assembly can produce up to about 28 gallons of potable recycled water each day," said Bob Bagdigian, Marshall Regenerative Environmental Control and Life Support System project manager. After the new systems are installed, annual delivered water to the ISS should decrease by approximately 15,960 pounds, or about 1,600 gallons.

Environmental Control and Life Support Integration Strategy for 6-Crew Operations

NASA Technical Reports Server (NTRS)

Duchesne, Stephanie M.; Tressler, Chad H.

2010-01-01

The International Space Station (ISS) crew complement has increased in size from 3 to 6 crew members. In order to support this increase in crew on ISS, the United States on-orbit Segment (USOS) has been outfitted with a suite of regenerative Environmental Control and Life Support (ECLS) hardware including an Oxygen Generation System (OGS), Waste and Hygiene Compartment (WHC), and a Water Recovery System (WRS). The WRS includes the Urine Processor Assembly (UPA) and the Water Processor Assembly (WPA). With this additional life support hardware, the ISS has achieved full redundancy in its on-orbit life support system between the t OS and Russian Segment (RS). The additional redundancy created by the Regenerative ECLS hardware creates the opportunity for independent support capabilities between segments, and for the first time since the start of ISS, the necessity to revise Life Support strategy agreements. Independent operating strategies coupled with the loss of the Space Shuttle supply and return capabilities in 2010 offer new and unique challenges. This paper will discuss the evolution of the ISS Life Support hardware strategy in support of 6-Crew on ISS, as well as the continued work that is necessary to ensure the support of crew and ISS Program objectives through the life of station

A case study of assigning conservation value to dispersed habitat units for conservation planning

USGS Publications Warehouse

Rohweder, Jason J.; Sara C. Vacek,; Crimmins, Shawn M.; Thogmartin, Wayne E.

2015-01-01

Resource managers are increasingly tasked with developing habitat conservation plans in the face of numerous, sometimes competing, objectives. These plans must often be implemented across dispersed habitat conservation units that may contribute unequally to overall conservation objectives. Using U.S. Fish and Wildlife Service waterfowl production areas (WPA) in western Minnesota as our conservation landscape, we develop a landscape-scale approach for evaluating the conservation value of dispersed habitat conservation units with multiple conservation priorities. We evaluated conservation value based on a suite of variables directly applicable to conservation management practices, thus providing a direct link between conservation actions and outcomes. We developed spatial models specific to each of these conservation objectives and also developed two freely available prioritization tools to implement these analyses. We found that some WPAs provided high conservation value across a range of conservation objectives, suggesting that managing these specific areas would achieve multiple conservation goals. Conversely, other WPAs provided low conservation value for some objectives, suggesting they would be most effectively managed for a distinct set of specific conservation goals. Approaches such as ours provide a direct means of assessing the conservation value of dispersed habitat conservation units and could be useful in the development of habitat management plans, particularly when faced with multiple conservation objectives.

Disrupted social development enhances the motivation for cocaine in rats.

PubMed

Baarendse, Petra J J; Limpens, Jules H W; Vanderschuren, Louk J M J

2014-04-01

Early social experiences are of major importance for behavioural development. In particular, social play behaviour during post-weaning development is thought to facilitate the attainment of social, emotional and cognitive capacities. Conversely, social insults during development can cause long-lasting behavioural impairments and increase the vulnerability for psychiatric disorders, such as drug addiction. The aim of this study was to investigate whether a lack of social experiences during the juvenile and early adolescent stage, when social play behaviour is highly abundant, alters cocaine self-administration in rats. Rats were socially isolated from postnatal days 21 to 42 followed by re-socialization until adulthood. Cocaine self-administration was then assessed under a fixed ratio and progressive ratio schedule of reinforcement. Next, cue, cocaine and stress-induced reinstatement of cocaine seeking was determined following extinction of self-administration. Early social isolation resulted in an enhanced acquisition of self-administration of a low dose (0.083 mg/infusion) of cocaine, but the sensitivity to cocaine reinforcement, assessed using a dose-response analysis, was not altered in isolated rats. Moreover, isolated rats displayed an increased motivation for cocaine under a progressive ratio schedule of reinforcement. Extinction and reinstatement of cocaine seeking was not affected by early social isolation. Early social isolation causes a long-lasting increase in the motivation to self-administer cocaine. Thus, aberrations in post-weaning social development, such as the absence of social play, enhance the vulnerability for drug addiction later in life.

Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice.

PubMed

Zhao, Yunan; Wang, Zhongli; Dai, Jianguo; Chen, Lin; Huang, Yufang; Zhan, Zhen

2012-03-17

Whether benzodiazepines (BZDs) have beneficial effects on the progress of chronic stress-induced impairment of hippocampal structural plasticity and major depression is uncertain. The present study designed four preclinical experiments to determine the effects of BZDs using chronic unpredictable stress model. In Experiment 1, several time course studies on behavior and hippocampus response to stress were conducted using the forced swim and tail suspension tests (FST and TST) as well as hippocampal structural plasticity markers. Chronic stress induced depression-like behavior in the FST and TST as well as decreased hippocampal structural plasticity that returned to normal within 3 wk. In Experiment 2, mice received p.o. administration of three diazepam dosages prior to each variate stress session for 4 wk. This treatment significantly antagonized the elevation of stress-induced corticosterone levels. Only low- (0.5mg/kg) and medium-dose (1mg/kg) diazepam blocked the detrimental effects of chronic stress. In Experiment 3, after 7 wk of stress sessions, daily p.o. diazepam administration during 1 wk recovery phase dose-dependently accelerated the recovery of stressed mice. In Experiment 4, 1 wk diazepam administration to control mice enhanced significantly hippocampal structural plasticity and induced an antidepressant-like behavioral effect, whereas 4 wk diazepam administration produced opposite effects. Hence, diazepam can slow the progress of chronic stress-induced detrimental consequences by normalizing glucocorticoid hormones. Considering the adverse effect of long-term diazepam administration on hippocampal plasticity, the preventive effects of diazepam may depend on the proper dose. Short-term diazepam treatment enhances hippocampal structural plasticity and is beneficial to recovery following chronic stress. Copyright © 2011 Elsevier B.V. All rights reserved.

Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors

PubMed Central

Ramsay, Douglas S; Woods, Stephen C; Kaiyala, Karl J

2014-01-01

Initial administration of 60% nitrous oxide (N2O) to rats at an ambient temperature of 21°C decreases core temperature (Tc), primarily via increased heat loss (HL). Over repeated N2O administrations, rats first develop tolerance to this hypothermia and subsequently exhibit hyperthermia (a sign-reversal) due primarily to progressive increases in heat production (HP). When rats initially receive 60% N2O in a thermal gradient, they become hypothermic while selecting cooler ambient temperatures that facilitate HL. This study investigated whether rats repeatedly administered 60% N2O in a thermal gradient would use the gradient to behaviorally facilitate, or oppose, the development of chronic tolerance and a hyperthermic sign-reversal. Male Long-Evans rats (N = 16) received twelve 3-h administrations of 60% N2O in a gas-tight, live-in thermal gradient. Hypothermia (Sessions 1–3), complete chronic tolerance (Sessions 4–6), and a subsequent transient hyperthermic sign-reversal (Sessions 7–12) sequentially developed. Despite the progressive recovery and eventual hyperthermic sign-reversal of Tc, rats consistently selected cooler ambient temperatures during all N2O administrations. A final 60% N2O administration in a total calorimeter indicated that the hyperthermic sign-reversal resulted primarily from increased HP. Thus, rats did not facilitate chronic tolerance development by moving to warmer locations in the gradient, and instead selected cooler ambient temperatures while simultaneously increasing autonomic HP. The inefficient concurrent activation of opposing effectors and the development of a sign-reversal are incompatible with homeostatic models of drug-adaptation and may be better interpreted using a model of drug-induced allostasis. PMID:25938127

28 CFR 523.20 - Good conduct time.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INMATE ADMISSION, CLASSIFICATION, AND... Educational Development (GED) credential. (c) For inmates serving a sentence for an offense committed on or... satisfactory progress toward earning a General Educational Development (GED) credential, to be eligible for a...

Apprentice Still Photographic Specialist (AFSC 23132).

ERIC Educational Resources Information Center

Air Univ., Gunter AFS, Ala. Extension Course Inst.

This four-volume student text is designed for use by Air Force personnel enrolled in a self-study extension course for apprentice still photographic specialists. Covered in the individual volumes are general subjects (career ladder progression, security, photographic safety, and photographic laboratory administration); still photographic…

Planning, Using the New Technology in Classrooms.

ERIC Educational Resources Information Center

Barker, Bruce O.

1990-01-01

"Technology talk" among progressive administrators includes more than just computers and VCRs. New telecommunications developments (in satellites, fiber optics, electronic bulletin boards, electronic mail, and two-way interactive instructional delivery) are "hot topics" that both principals and teachers must learn about. Peer interactions and…

ADULT EDUCATION IN NEPAL.

ERIC Educational Resources Information Center

HELY, ARNOLD S.M.

IN THIS REPORT ON ADULT EDUCATION IN NEPAL, THE GEOGRAPHIC, ETHNIC, ECONOMIC, EDUCATIONAL, AND POLITICAL FACTORS AFFECTING SOCIAL, EDUCATIONAL, AND ECONOMIC DEVELOPMENT ARE DISCUSSED. THE EXTENT OF PROGRESS IN NATIONAL EDUCATION (INCLUDING LITERACY CAMPAIGNS) SINCE 1951 PROVIDES BACKGROUND FOR A DESCRIPTION OF THE ADMINISTRATIVE ORGANIZATION AND…

MITOCHONDRIAL DAMAGE UPON CADMIUM-METALLOTHIONEIN ADMINISTRATION IS DUE TO CD++. (U915642)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Six Strategies for Chemical Waste Minimization in Laboratories.

ERIC Educational Resources Information Center

Matteson, Gary C.; Hadley, Cheri R.

1991-01-01

Guidelines are offered to research administrators for reducing the volume of hazardous laboratory waste. Suggestions include a chemical location inventory, a chemical reuse facility, progressive contracts with chemical suppliers, internal or external chemical recycling mechanisms, a "chemical conservation" campaign, and laboratory fees for…

Interim report to the U.S. Congress on the Nonmotorized Transportation Pilot Program, SAFETEA-LU Section 1807

DOT National Transportation Integrated Search

2007-11-01

This interim report to Congress summarizes the progress and initial results of the Federal Highway Administrations (FHWA) and the four pilot communities participation in the Nonmotorized Transportation Pilot Program (NTPP) from its inception th...

Vitamin D delays breast cancer progression in the PyVMT transgenic mouse model: local conversion of the precursor 25(OH)D3 into 1,25(OH)2D3 is safer and more effective than systemic administration of 1,25(OH)2D3

USDA-ARS?s Scientific Manuscript database

Metabolic activation of 1,25(OH)2D3 occurs at extra renal sites in several organs, including the breast. The purpose of this study was to determine if this local tumoral 25OHD3-1alphahydroxylase expression modulates any or all of the stages of breast tumor progression. For this purpose we used the...

Influence of vehicles used for oral dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice.

PubMed

Singh, Shubhra; Dwivedi, Richa; Chaturvedi, Vinita

2012-11-01

Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl sulfoxide, and polysorbate-80 on the progression of Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time and body weight) and bacteriological (viable counts in lungs) parameters. Compared with water, corn oil significantly improved both sets of parameters, whereas the other vehicles affected only physical parameters.

Influence of Vehicles Used for Oral Dosing of Test Molecules on the Progression of Mycobacterium tuberculosis Infection in Mice

PubMed Central

Singh, Shubhra; Dwivedi, Richa

2012-01-01

Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl sulfoxide, and polysorbate-80 on the progression of Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time and body weight) and bacteriological (viable counts in lungs) parameters. Compared with water, corn oil significantly improved both sets of parameters, whereas the other vehicles affected only physical parameters. PMID:22926571

Professional advancement of women in health care management: a conceptual model.

PubMed

Madsen, M K; Blide, L A

1992-11-01

Ragins and Sundstrom suggest three major conclusions based on power and gender differences within organizations. The first is that power develops or detracts as individuals progress along their career track. HIM professionals who accept the challenges that changing roles bring can also develop a new sensitivity to the value of power as a tool. They can use their negotiating skills to avoid being placed in work roles that result in a decrease in power. The second difference between men and women within organizations is that obstacles often impede women's career paths more than men's. Perceptions by women and men of a woman as homemaker and mother create serious conflicts when jobs are demanding and time intensive. Lastly, Ragins and Sundstrom suggest that career progression is influenced by both intrinsic factors (personal and professional) and extrinsic factors (organizational and interpersonal). The interaction between these factors is often driven by gender differences allowing men to progress and succeed, whereas women remain beneath the glass ceiling. HIM professionals, like other women health professionals, are graduating from advanced programs in health care and business administration at a greater rate than ever before in the history of this country. Not all these graduates will be able to acquire top-level administrative positions in the traditional health care institutions (e.g., hospitals). Therefore, if they wish to advance, they may have to move to nontraditional work settings. This is especially true for HIM professionals. The expanding computerized environment in traditional and nontraditional health care settings presents great potential for the development of new roles and responsibilities that have not been identified as male roles. HIM professionals and women in other health care professions who aspire to advance to upper administrative positions in traditional and nontraditional settings must be willing to take the risks inherent in assuming these changing roles and responsibilities. Successful women leaders in upper administrative positions recognize and take opportunities when they are offered and are not reluctant to assume more responsibilities and power in an organization. Lastly, if women are to move through the glass ceiling, health care institutions must become sensitized to the factors that prevent women's advancement and facilitate entry-level opportunities for women in administration. Continuing education and opportunities for mentoring and networking, combined with flexibility in work structures, will promote the integration of women at high administrative levels in health care, not only within their own professions, but in corporate health care as well.

Documenting the NICU design dilemma: comparative patient progress in open-ward and single family room units

PubMed Central

Domanico, R; Davis, D K; Coleman, F; Davis, B O

2011-01-01

Objective: To test the efficacy of single family room (SFR) neonatal intensive care unit (NICU) designs, questions regarding patient medical progress and relative patient safety were explored. Addressing these questions would be of value to hospital staff, administrators and designers alike. Study Design: This prospective study documented, by means of Institution Review Board-approved protocols, the progress of patients in two contrasting NICU designs. Noise levels, illumination and air quality measurements were included to define the two NICU physical environments. Result: Infants in the SFR unit had fewer apneic events, reduced nosocomial sepsis and mortality, as well as earlier transitions to enteral nutrition. More mothers sustained stage III lactation, and more infants were discharged breastfeeding in the SFR. Conclusion: This study showed the SFR to be more conducive to family-centered care, and to enhance infant medical progress and breastfeeding success over that of an open ward. PMID:21072040

Progressive renal insufficiency related to ALK inhibitor, alectinib.

PubMed

Nagai, Kojiro; Ono, Hiroyuki; Matsuura, Motokazu; Hann, Michael; Ueda, Sayo; Yoshimoto, Sakiya; Tamaki, Masanori; Murakami, Taichi; Abe, Hideharu; Ishikura, Hisashi; Doi, Toshio

2018-04-01

Alectinib is a second generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor and is generally effective and tolerated in patients who have demonstrated disease progression or adverse effects while on the first generation inhibitor, crizotinib. ALK inhibitors can cause a reversible chronic increase of serum creatinine concentration; however, they rarely induce progressive renal insufficiency. We herein report a case of a 68-year-old woman diagnosed with ALK-positive advanced non-small cell lung cancer and who received ALK inhibitors. Due to dysgeusia and transaminitis, her medication was switched from crizotinib to alectinib. Rapid progressive glomerulonephritis developed 1 year after the initiation of alectinib treatment. A renal biopsy revealed unique kidney lesions in both tubules and glomeruli. Glucocorticoid therapy partially reversed kidney impairment. However, re-administration of alectinib caused kidney dysfunction, which was improved by the cessation of alectinib. Our case suggests that much attention should be paid to kidney function when using ALK inhibitors.

Gamma-glutamylcysteinylethyl ester attenuates progression of carbon tetrachloride-induced acute liver injury in mice.

PubMed

Nishida, K; Ohta, Y; Ishiguro, I

1998-02-20

We examined the effect of gamma-glutamylcysteinylethyl ester (gamma-GCE), which is readily transported into hepatocytes and increases hepatocellular reduced glutathione (GSH) levels, on the progression of carbon tetrachloride (CCl4)-induced liver injury in mice in comparison with that of GSH. Administration of more than 160 micromol/kg of gamma-GCE, but not GSH, to mice at 3 h after intraperitoneal injection of CCl4 (1 ml/kg) significantly attenuated increases in serum aspartate aminotransferase and alanine aminotransferase activities at 24 h after the CCl4 injection. Increases in hepatic lipid peroxide (LPO) concentrations and decreases in hepatic GSH concentrations after the CCl4 injection were significantly diminished by the gamma-GCE (160 micromol/kg) administration, but not by the same dose of GSH. Gamma-GCE, gamma-glutamylcysteine, and cysteine acted as substrates for glutathione peroxidases much less efficiently than GSH in the post-mitochondrial fraction of normal mouse liver cells. These results indicate that gamma-GCE attenuates the progression of CCl4-induced acute liver injury in mice through the maintenance of hepatic GSH levels, leading to inhibition of hepatic LPO formation, which could be due to an efficient utilization of GSH converted from gamma-GCE in the liver cells.

Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis?

PubMed

De Brouwer, Bart; Piscaer, Ianthe; Von Der Thusen, Jan H; Grutters, Jan C; Schutgens, Roger Eg; Wouters, Emiel Fm; Janssen, Rob

2018-03-01

There is an ongoing need for additional interventions in idiopathic pulmonary fibrosis (IPF) as antifibrotic drugs currently available only inhibit and do not stall disease progression. Vitamin K is a co-factor for the activation of coagulation factors. However, it is also required to activate proteins with functions outside of the coagulation cascade, such as matrix Gla protein (MGP), a defender against soft tissue calcification. Vitamin K antagonists are anticoagulants that are, for unknown reasons, associated with increased mortality in IPF. Areas covered: We advance the hypothesis that modulation of vitamin K-dependent MGP activation in IPF patients by either vitamin K antagonism or administration may result in acceleration and deceleration of fibrosis progression, respectively. Furthermore, shortfall in vitamin K could be suspected in IPF based on the high prevalence of certain co-morbidities, such as vascular calcification and lung cancer. Expert commentary: We hypothesize that vitamin K status is reduced in IPF patients. This, in combination with studies suggesting that vitamin K may play a role in lung fibrosis pathogenesis, would provide a rationale for conducting a clinical trial assessing the potential mitigating effects of vitamin K administration on progression of lung fibrosis, prevention of co-morbidities and mortality in IPF.

ANNUAL REPORT, JULY 1, 1958

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1959-02-01

This annual report of Brookhaven National Laboratory describes its program and activities for the fiscal year 1958. The progress and trends of the research program are presented along with a description of the operational, service, and administrative activities of the Laboratory. The scientific and technical details of the many research and development activities are covered more fully in scientific and technical periodicals and in the quarterly scientific progress reports and other scientiflc reports of the Laboratory. A list of all publications for July 1, 1957 to June 30, 1958, is given. Status and progress are given in fields of physics,more » accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medical research. (For preceding period see BNL-462.) (W.D.M.)« less

SIV/Macaque Model of HIV Infection in Cocaine Users: Minimal Effects of Cocaine on Behavior, Virus Replication, and CNS Inflammation

PubMed Central

Weed, Michael; Adams, Robert J.; Hienz, Robert D.; Meulendyke, Kelly A.; Linde, Michael E.; Clements, Janice E.; Mankowski, Joseph L.; Zink, M. Christine

2011-01-01

Studies of the effects of drugs of abuse on HIV immune status, disease progression, and neuroAIDS have produced conflicting data and have not definitively shown whether this combination promotes cognitive impairment or disease progression. Using a consistent SIV–macaque model, we investigated the effects of cocaine on behavior, virologic parameters, and CNS inflammation. Macaques received either vehicle or chronic administration of behaviorally active doses of cocaine (1.7 or 3.2 mg/kg/day). Chronic cocaine administration reduced CD8+ T cell counts during acute and late stage infection but had no effect on CD4+ T cell counts. Low-dose cocaine-treated animals had lower CSF vRNA levels late in infection, but cocaine did not alter plasma viral load or vRNA or protein in brain. There were no differences in CSF CCL-2 or interleukin (IL)-6 levels or severity of encephalitis in cocaine-treated as compared to vehicle-treated macaques. There were no differences in brain inflammation or neurodegeneration markers, as determined by interferon (IFN)-β, MxA, CCL2, IL-6, TNFα, IFNγ, and indolamine 2,3-deoxygenase mRNA levels. APP levels also were not altered. The executive function of inhibitory control was not impaired in cocaine-treated or control animals following SIV infection. However, animals receiving 3.2 mg/kg/day cocaine performed more slowly in a bimanual motor test. Thus, chronic administration of cocaine produced only minor changes in behavior, encephalitis severity, CNS inflammation/neurodegeneration, and virus replication in SIV-infected pigtailed macaques, suggesting that cocaine would have only modest effects on the progression of neuroAIDS in HIV-infected individuals. PMID:21626125

GC protein-derived macrophage-activating factor decreases α-N-acetylgalactosaminidase levels in advanced cancer patients.

PubMed

Thyer, Lynda; Ward, Emma; Smith, Rodney; Branca, Jacopo Jv; Morucci, Gabriele; Gulisano, Massimo; Noakes, David; Eslinger, Robert; Pacini, Stefania

2013-08-01

α- N -acetylgalactosaminidase (nagalase) accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness and clinical disease progression. The administration of GC protein-derived macrophage-activating factor (GcMAF) to cancer patients with elevated levels of nagalase has been associated with a decrease of serum nagalase activity and with significant clinical benefits. Here, we report the results of the administration of GcMAF to a heterogeneous cohort of patients with histologically diverse, advanced neoplasms, generally considered as "incurable" diseases. In most cases, GcMAF therapy was initiated at late stages of tumor progression. As this is an open-label, non-controlled, retrospective analysis, caution must be employed when establishing cause-effect relationships between the administration GcMAF and disease outcome. However, the response to GcMAF was generally robust and some trends emerged. All patients (n = 20) presented with elevated serum nagalase activity, well above normal values. All patients but one showed a significant decrease of serum nagalase activity upon weekly GcMAF injections. Decreased nagalase activity was associated with improved clinical conditions and no adverse side effects were reported. The observations reported here confirm and extend previous results and pave the way to further studies aimed at assessing the precise role and indications for GcMAF-based anticancer immunotherapy.

Effect of everolimus on the pharmacokinetics of octreotide long-acting repeatable in patients with advanced neuroendocrine tumors: An analysis of the randomized phase III RADIANT-2 trial.

PubMed

Pavel, M E; Becerra, C; Grosch, K; Cheung, W; Hasskarl, J; Yao, J C

2017-04-01

In the RADIANT-2 trial, addition of everolimus to octreotide long-acting repeatable (LAR) exhibited a clinically meaningful 5.1-month improvement in progression-free survival (PFS) in patients with advanced functional neuroendocrine tumors. In this study, we characterized the effects of everolimus co-administration on octreotide LAR pharmacokinetics and its relationship with efficacy and safety. At least one evaluable blood everolimus and plasma octreotide predose minimum concentration (C min ) was available for 182 patients and 294 patients, respectively. Concomitant everolimus administration increased octreotide C min with a geometric mean ratio (everolimus/placebo) of 1.47 (90% confidence interval [CI] = 1.32-1.64). Risk for progression was consistently reduced when everolimus C min was increased twofold, regardless of octreotide exposure (hazard ratio [HR] = 0.74; 95% CI = 0.46-1.18; HR = 0.54; 95% CI = 0.32-0.92 for 6 ng/mL and 4 ng/mL octreotide, respectively). Risk for pulmonary or metabolic events was associated with increased everolimus C min . Co-administration of everolimus plus octreotide LAR increased octreotide C min , which did not impact efficacy. © 2016 American Society for Clinical Pharmacology and Therapeutics.

45 CFR 400.28 - Maintenance of records and reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM... services; (2) Records on the location, progress, and status of unaccompanied minor refugee children, including the last known address of parents; and (3) Documentation that necessary medical followup services...

Exceptional Children Information Center--Progress and Potential

ERIC Educational Resources Information Center

Jordan, June B.; And Others

1970-01-01

Defines the scope and function of the ERIC Clearinghouse on Exceptional Children (ERIC/CEC). This clearinghouse also serves as a comprehensive source of information on research instructional materials, programs, administration, teacher education, methods, and special education curricula in the Special Education IMC/RMC Network. (DE)

7 CFR 2610.1 - General statement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the Secretary and the Congress informed of problems and deficiencies relative to the programs and... policies and programs. (2) Provide for the personal security of the Secretary and Deputy Secretary. (3... problems and deficiencies and the necessity for and progress of corrective actions in the administration of...

How One Teacher Uses Student Records. Profiles/Dolly Lambdin.

ERIC Educational Resources Information Center

Locke, Lawrence F.; Dodds, Patt

1982-01-01

A physical education teacher has created a recordkeeping system which maintains a continuous record of each student's progress in fitness tests, basic motor skills, specific play skills, and interpersonal behavior. The system helps with student motivation, administration, decision making, and building parental support. (PP)

Educational Leadership in the New Millennium: A Vision for 2020.

ERIC Educational Resources Information Center

Miller, Thomas W.; Miller, Jean M.

2001-01-01

In assessing educational leadership dimensions for 2020, one must consider the effects of technology and automation in education, important influences of changes in society, and progress in developing and understanding administrators' personal/professional needs. Conscience, creative imagination, and interpersonal skill development are essential…

Division File of Extension Research Materials; Additions During 1968.

ERIC Educational Resources Information Center

Byrn, Darcie, Comp.

In this annotated bibliography of acquisitions during 1968 appear 265 Extension studies on administrative organization and management; training and staff development; mobilizing participation in Extension work; local leadership; program content and planning procedures; general effectiveness and progress in Extension; teaching methods, techniques,…

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2013 CFR

2013-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2012 CFR

2012-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2014 CFR

2014-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2011 CFR

2011-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

77 FR 17488 - Amendment to Proposed Collection: Comment Request Post-Award Reporting Requirements Including New...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Amendment to Proposed Collection: Comment Request Post-Award Reporting Requirements Including New Research Performance Progress... Ellis, Director, Office of Policy for Extramural Research Administration, Office of Extramural Research...

20 CFR 404.1660 - How we will monitor.

Code of Federal Regulations, 2010 CFR

2010-04-01

....1660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Determinations of Disability Performance Monitoring and Support § 404.1660 How we will... making and the type and extent of performance support we will provide to help the State progress toward...

20 CFR 416.1060 - How we will monitor.

Code of Federal Regulations, 2010 CFR

2010-04-01

....1060 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Determinations of Disability Performance Monitoring and Support § 416.1060 How we... making and the type and extent of performance support we will provide to help the State progress toward...

13 CFR 113.520 - Job classification and structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or Activities... males or for females; (b) Maintain or establish separate lines of progression, seniority lists, career...

13 CFR 113.520 - Job classification and structure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or Activities... males or for females; (b) Maintain or establish separate lines of progression, seniority lists, career...

13 CFR 113.520 - Job classification and structure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or Activities... males or for females; (b) Maintain or establish separate lines of progression, seniority lists, career...

13 CFR 113.520 - Job classification and structure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or Activities... males or for females; (b) Maintain or establish separate lines of progression, seniority lists, career...

13 CFR 113.520 - Job classification and structure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or Activities... males or for females; (b) Maintain or establish separate lines of progression, seniority lists, career...

Deconstructing the vanilla milkshake: the dominant effect of sucrose on self-administration of nutrient-flavor mixtures.

PubMed

Naleid, Amy M; Grimm, Jeffrey W; Kessler, David A; Sipols, Alfred J; Aliakbari, Sepideh; Bennett, Jennifer L; Wells, Jason; Figlewicz, Dianne P

2008-01-01

Rats and humans avidly consume flavored foods that contain sucrose and fat, presumably due to their rewarding qualities. In this study, we hypothesized that the complex mixture of corn oil, sucrose, and flavor is more reinforcing than any of these components alone. We observed a concentration-dependent increase in reinforcers of sucrose solutions received (0%, 3%, 6.25%, and 12.5%) in both fixed ratio and progressive ratio procedures, but with equicaloric corn oil solutions (0%, 1.4%, 2.8%, and 5.6%) this finding was replicated only in the fixed ratio procedure. Likewise, addition of 1.4% oil to 3% or 12.5% sucrose increased fixed ratio, but not progressive ratio, reinforcers received relative to those of sucrose alone. Finally, addition of 3% vanilla flavoring did not change self-administration of 3% sucrose or 3% sucrose+1.4% oil solutions. These data suggest that, calorie-for-calorie, sucrose is the dominant reinforcing component of novel foods that contain a mixture of fat, sucrose, and flavor.

Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy

PubMed Central

Larkindale, Jane; Abresch, Richard; Aviles, Enrique; Bronson, Abby; Chin, Janice; Furlong, Pat; Gordish-Dressman, Heather; Habeeb-Louks, Elizabeth; Henricson, Erik; Kroger, Hans; Lynn, Charles; Lynn, Stephen; Martin, Dana; Nuckolls, Glen; Rooney, William; Romero, Klaus; Sweeney, Lee; Vandenborne, Krista; Walter, Glenn; Wolff, Jodi; Wong, Brenda; McDonald, Craig M.; Duchenne Regulatory Science Consortium, Imaging-DMD Consortium and the CINRG Investigators, members of the

2017-01-01

Introduction: The Duchenne Regulatory Science Consortium (D-RSC) was established to develop tools to accelerate drug development for DMD.  The resulting tools are anticipated to meet validity requirements outlined by qualification/endorsement pathways at both the U.S. Food and Drug Administration (FDA) and European Medicines Administration (EMA), and will be made available to the drug development community. The initial goals of the consortium include the development of a disease progression model, with the goal of creating a model that would be used to forecast changes in clinically meaningful endpoints, which would inform clinical trial protocol development and data analysis.  Methods: In April of 2016 the consortium and other experts met to formulate plans for the development of the model.  Conclusions: Here we report the results of the meeting, and discussion as to the form of the model that we plan to move forward to develop, after input from the regulatory authorities. PMID:28228973

Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy

PubMed Central

Pranjol, Md Zahidul Islam; Hajitou, Amin

2015-01-01

Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration. PMID:25606974

Bacteriophage-derived vectors for targeted cancer gene therapy.

PubMed

Pranjol, Md Zahidul Islam; Hajitou, Amin

2015-01-19

Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration.

Administrative Information Systems Plan for FY89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-11-01

The Administrative Information Systems (AIS) Plan was developed to prioritize, track, and control the cost of AIS activities. This annually published plan, in conjunction with quarterly status reports, measures projected AIS activities and progress. The AIS Plan and quarterly reporting are administered jointly by the Director of Computing and an Organization 30 director. Priority development projects are clearly defined and closely managed efforts that consume significant resources. Directorate supplementals describe other AIS activity within each directorate, which may include: production support; technical support; development activity; and other AIS effort.

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator for Space Technology, Mike Gazarik, Ph.D, listens to a question from the audience during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

Asteroid Initiative Industry and Partner Day

NASA Image and Video Library

2013-06-18

NASA Associate Administrator for Human Exploration and Operations, William Gerstenmaier, listens to a question from the audience during the Asteroid Initiative Industry and Partner Day at NASA Headquarters on Tuesday, June 18, 2013 in Washington. During the event NASA Deputy Administrator Lori Garver and other senior NASA officials discussed the progress being made on NASA's mission to capture, redirect, and explore an asteroid. NASA also announced an Asteroid Grand Challenge focused on finding all asteroid threats to human populations and knowing what to do about them. Photo Credit: (NASA/Bill Ingalls)

National Space Council Meeting from the White House

NASA Image and Video Library

2018-06-18

NASA Administrator Jim Bridenstine attends the third meeting of the National Space Council in the East Room of the White House, Monday, June 18, 2018, in Washington. President Trump kicked off the meeting by signing Space Policy Directive-3, which directs the U.S. to lead space traffic management and mitigate the effects of space debris. Vice President Mike Pence led the meeting, joined by other government officials. Administrator Bridenstine reported on NASA's progress in implementing Space Policy Directive-1, which directs NASA to return astronauts to the Moon and eventually send humans to Mars.

Extended Mortality and Chronic Kidney Disease After Septic Acute Kidney Injury.

PubMed

Chua, Horng-Ruey; Wong, Weng-Kin; Ong, Venetia Huiling; Agrawal, Dipika; Vathsala, Anantharaman; Tay, Hui-Ming; Mukhopadhyay, Amartya

2018-01-01

To evaluate 1-year mortality in patients with septic acute kidney injury (AKI) and to determine association between initial AKI recovery patterns ( reversal within 5 days, beyond 5 days but recovery, or nonrecovery) and chronic kidney disease (CKD) progression. Prospective observational study, with retrospective evaluation of initial nonconsenters, of critically ill patients with septic AKI. We studied 207 patients (age, mean [SD]: 64 [16] years, 39% males), of which 56 (27%), 18 (9%), and 9 (4%) died in intensive care unit (ICU), post-ICU in hospital, and posthospitalization, respectively. Infections (including pneumonia) and major adverse cardiac events accounted for 64% and 12% of deaths, respectively. Factors independently associated with 1-year mortality include older age, ischemic heart disease, higher Simplified Acute Physiology Score II, central nervous system or musculoskeletal primary infections, higher daily fluid balance (FB), and frusemide administration during ICU stay (all P < .05). Among 63 patients receiving renal replacement therapy (RRT), hospital mortality was higher with cumulative median FB >8 L versus ≤8 L at RRT initiation (57% vs 24%; P = .009); there was trend for less ICU- and RRT-free days at day 28 in patients with higher FB pre-RRT ( P = NS). Chronic kidney disease progression over 1 year developed in 21%, 30%, and 79% of 105 initial survivors with AKI reversal, recovery, and nonrecovery, respectively ( P < .001). Acute kidney injury nonrecovery during hospitalization independently predicted CKD progression ( P = .001). Patients with septic AKI had 40% 1-year mortality, mainly associated with infections. High FB and frusemide administration were modifiable risk factors. Risk of CKD progression is high especially with initial AKI nonrecovery.

Alectinib for advanced ALK-positive non-small-cell lung cancer.

PubMed

Ly, Ashley C; Olin, Jacqueline L; Smith, Morgan B

2018-04-15

The pharmacology, pharmacokinetics, clinical efficacy, safety and tolerability, dosage and administration, and place in therapy of alectinib for treatment of patients with non-small-cell lung cancer (NSCLC) are reviewed. In patients with NSCLC driven by mutations of ALK , the gene coding for anaplastic lymphoma kinase (ALK), treatment with the ALK inhibitor crizotinib has been found to provide median progression-free survival (PFS) of 10.9 months; however, therapeutic failures and tumor progression to brain metastases are common with crizotinib use, prompting research to find more potent and tolerable ALK inhibitors that target major oncogenic drivers of NSCLC. Alectinib is a next-generation ALK inhibitor initially approved by the Food and Drug Administration for use in patients with metastatic ALK -positive NSCLC who are intolerant of or have disease progression during crizotinib therapy. In clinical trials, alectinib was found effective for delaying disease progression and, more importantly, reducing brain metastases in patients with NSCLC who developed resistance or intolerance to previous crizotinib therapy. Published data from clinical trials indicate that the most common grade 1 and 2 adverse effects associated with alectinib use are fatigue, constipation, peripheral edema, and myalgia; the most common grade 3 or 4 reactions include increases in creatine phosphokinase, alanine aminotransferase, and aspartate aminotransferase levels. Alectinib appears to be effective and safe for use in patients with metastatic ALK -positive NSCLC, with demonstrated superiority over crizotinib in terms of PFS rates. Research to better define ALK inhibitor resistance mechanisms and alectinib's place in therapy is ongoing. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Long-term changes of information environments and computer anxiety of nurse administrators in Japan.

PubMed

Majima, Yukie; Izumi, Takako

2013-01-01

In Japan, medical information systems, including electronic medical records, are being introduced increasingly at medical and nursing fields. Nurse administrators, who are involved in the introduction of medical information systems and who must make proper judgment, are particularly required to have at least minimal knowledge of computers and networks and the ability to think about easy-to-use medical information systems. However, few of the current generation of nurse administrators studied information science subjects in their basic education curriculum. It can be said that information education for nurse administrators has become a pressing issue. Consequently, in this study, we conducted a survey of participants taking the first level program of the education course for Japanese certified nurse administrators to ascertain the actual conditions, such as the information environments that nurse administrators are in, their anxiety attitude to computers. Comparisons over the seven years since 2004 revealed that although introduction of electronic medical records in hospitals was progressing, little change in attributes of participants taking the course was observed, such as computer anxiety.

U.S. Food and Drug Administration Approval Summary: Ramucirumab for the Treatment of Metastatic Non-Small Cell Lung Cancer Following Disease Progression On or After Platinum-Based Chemotherapy.

PubMed

Larkins, Erin; Scepura, Barbara; Blumenthal, Gideon M; Bloomquist, Erik; Tang, Shenghui; Biable, Missiratch; Kluetz, Paul; Keegan, Patricia; Pazdur, Richard

2015-11-01

On December 12, 2014, the U.S. Food and Drug Administration (FDA) approved ramucirumab for use in combination with docetaxel for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with disease progression on or after platinum-based chemotherapy. Patients with epidermal growth factor receptor or anaplastic lymphoma kinase genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving ramucirumab. This approval was based on an improvement in overall survival (OS) with an acceptable toxicity profile in a randomized, multicenter, double-blinded, placebo-controlled trial of 1,253 patients with metastatic NSCLC previously treated with a platinum-based combination therapy. Patients were randomized 1:1 to receive either ramucirumab in combination with docetaxel or placebo in combination with docetaxel. The primary endpoint was OS. Patients who received ramucirumab in combination with docetaxel had improved OS (hazard ratio [HR]: 0.86; 95% confidence interval [CI]: 0.75, 0.98). Median OS was 10.5 months on the ramucirumab plus docetaxel arm versus 9.1 months on the placebo plus docetaxel arm. The most frequent (≥ 30%) adverse reactions in ramucirumab-treated patients were fatigue, neutropenia, and diarrhea. The most frequent (≥ 5%) grade 3 and 4 adverse reactions in the ramucirumab arm were fatigue, neutropenia, febrile neutropenia, leukopenia, and hypertension. This report presents key information on the U.S. Food and Drug Administration approval of ramucirumab, a monoclonal antibody targeting vascular endothelial growth factor receptor-2, given in combination with docetaxel for the treatment of patients with metastatic non-small cell lung cancer whose disease has progressed on or after platinum-based chemotherapy. This report specifically addresses the issues of safety in patients with squamous cell tumors, effect of treatment in elderly patients, and uncertainties regarding effects in patients with tumors harboring epidermal growth factor receptor or anaplastic lymphoma kinase genomic tumor aberrations. ©AlphaMed Press.

Educational Evaluation and the Hartman Value Profile.

ERIC Educational Resources Information Center

Byrum, Stephen C.

1979-01-01

A tool consisting of 2 sets of 18 statements and requiring 20 minutes for administration, the Hartman Value Profile evaluates progress and maturity in areas not readily adaptable to more objective means of evaluation. Firsthand experiences with the HVP have indicated successful evaluations of postsecondary student thinking. (JC)

Ocean Thermal Energy Conversion (OTEC)

NASA Technical Reports Server (NTRS)

Lavi, A.

1977-01-01

Energy Research and Development Administration research progress in Ocean Thermal Energy Conversion (OTEC) is outlined. The development program is being focused on cost effective heat exchangers; ammonia is generally used as the heat exchange fluid. Projected costs for energy production by OTEC vary between $1000 to $1700 per kW.

Predicting Success of Developmental Math Students

ERIC Educational Resources Information Center

Martinez, Isaac

2017-01-01

Addressing the needs of developmental math students has been one of the most challenging problems in higher education. Administrators at a private university were concerned about poor academic performance of math-deficient students and sought to identify factors that influenced students' successful progression from developmental to college-level…

Problems in Office Management: Cases in Practice

ERIC Educational Resources Information Center

Hemby, K. Virginia; Smith, Vincent W.

2006-01-01

Office managers face an increasing array of job responsibilities in today's business environment. To prepare new office administration employees and managers, educational institutions must maintain a progressive curriculum to meet position demands. Using a population of members of the Association of Professional Office Managers, this study was…

34 CFR 75.732 - Records related to performance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Records related to performance. 75.732 Section 75.732 Education Office of the Secretary, Department of Education DIRECT GRANT PROGRAMS What Are the Administrative...) Determine progress in accomplishing project objectives; and (2) Revise those objectives, if necessary...

Reframing Retention Strategy: A Focus on Progress

ERIC Educational Resources Information Center

Spittle, Brian

2013-01-01

Few words have dominated the vocabulary of college retention as has the word "persistence." Many institutions still struggle to engage faculty and administrators in building campuswide retention efforts, to find the organizational levers that translate the abstractions and complexities of retention theory into scalable and durable initiatives, and…

Build Better ePortfolios

ERIC Educational Resources Information Center

Zuger, Sascha

2008-01-01

Tech-using educators know the many benefits of ePortfolios. They help get a handle on kids' interests, difficulties, and strengths. Techno-loving student thrive on the real-time interaction. Administrators like that ePortfolios record student progress digitally, making a convenient shared resource between students, parents, and other teachers.…

COBEL model as part of a terminal-area ceiling and visibility (C and V) nowcast system : a progress report

DOT National Transportation Integrated Search

1996-07-18

The Federal Aviation Administration (FAA) Integrated Terminal Weather System (ITWS) is supporting the development of products aimed at providing automated guidance to the air traffic managers for the anticipation of changes in ceiling and visibility ...

Research administration, state planning & research part II program : FY2012 at-a-glance.

DOT National Transportation Integrated Search

2012-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year (FY) 2012. The tables on pages 2 through 7 list all MDOT-funded research projects by focus area that were active or completed during 2...

Research administration, state planning & research part II program : FY2013 at-a-glance.

DOT National Transportation Integrated Search

2014-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year : (FY) 2013. The tables on pages 2 through 7 list all MDOT-funded research projects by topic area that were active : or completed duri...

77 FR 56811 - United States Travel and Tourism Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... DEPARTMENT OF COMMERCE International Trade Administration United States Travel and Tourism... the United States Travel and Tourism Advisory Board (Board). The Board will meet to present updates on... implementation of the National Travel and Tourism Strategy and the progress on implementing the President's...

48 CFR 1819.7213 - Performance reviews.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Performance reviews. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7213 Performance reviews. (a) NASA OSBP will conduct annual performance reviews of the progress and accomplishments...

48 CFR 1819.7213 - Performance reviews.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Performance reviews. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7213 Performance reviews. (a) NASA OSBP will conduct annual performance reviews of the progress and accomplishments...

28 CFR 2.64 - Youth Corrections Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... referred to the Bureau's regional correctional programs administrator with the recommended changes... decision on approving or disapproving each program plan on behalf of the Commission. Once the program plan... decision). (5) The institution shall send a progress report to the Commission: (i) No more than 60 days...

28 CFR 2.64 - Youth Corrections Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... referred to the Bureau's regional correctional programs administrator with the recommended changes... decision on approving or disapproving each program plan on behalf of the Commission. Once the program plan... decision). (5) The institution shall send a progress report to the Commission: (i) No more than 60 days...

Review of Tax Policy and Reform Issues.

ERIC Educational Resources Information Center

MacPhail-Wilcox, Bettye

1982-01-01

Summarizes the activities of the 97th Congress on taxes. Reviews 1981 enactments and 1982 proposals regarding tax cuts, tax increases, indexing of tax brackets, interest earnings, depreciation, and business incentives. Examines tax administration problems and flat-rate tax proposals and discusses the progressive income tax. (Author/RW)

48 CFR 1819.7213 - Performance reviews.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Performance reviews. 1819... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7213 Performance reviews. (a) NASA OSBP will conduct annual performance reviews of the progress and accomplishments...

46 CFR 380.24 - Schedule of retention periods and description of records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... bonds, salvage data, and claim files; (4) Contracts, agreements, franchises, licenses, etc., such as subsidy, charter, ship construction, and pooling agreements; (5) Vessel operating records such as log... Administration: (1) Ship construction or reconversion records such as bids, plans, progress payments, and...

46 CFR 380.24 - Schedule of retention periods and description of records.

Code of Federal Regulations, 2014 CFR

2014-10-01

... bonds, salvage data, and claim files; (4) Contracts, agreements, franchises, licenses, etc., such as subsidy, charter, ship construction, and pooling agreements; (5) Vessel operating records such as log... Administration: (1) Ship construction or reconversion records such as bids, plans, progress payments, and...

46 CFR 380.24 - Schedule of retention periods and description of records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... bonds, salvage data, and claim files; (4) Contracts, agreements, franchises, licenses, etc., such as subsidy, charter, ship construction, and pooling agreements; (5) Vessel operating records such as log... Administration: (1) Ship construction or reconversion records such as bids, plans, progress payments, and...

46 CFR 380.24 - Schedule of retention periods and description of records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... bonds, salvage data, and claim files; (4) Contracts, agreements, franchises, licenses, etc., such as subsidy, charter, ship construction, and pooling agreements; (5) Vessel operating records such as log... Administration: (1) Ship construction or reconversion records such as bids, plans, progress payments, and...

46 CFR 380.24 - Schedule of retention periods and description of records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... bonds, salvage data, and claim files; (4) Contracts, agreements, franchises, licenses, etc., such as subsidy, charter, ship construction, and pooling agreements; (5) Vessel operating records such as log... Administration: (1) Ship construction or reconversion records such as bids, plans, progress payments, and...

Progress on the development of a master file of highway safety planning and evaluation data.

DOT National Transportation Integrated Search

1981-01-01

The National Highway Traffic Safety Administration requires each state to submit an annual Highway Safety Plan as a prerequisite for obtaining federal section 402 safety monies. The Highway Safety Plan serves as more than a mechanism for obtaining fu...

36 CFR 1211.520 - Job classification and structure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or... as being for males or for females; (b) Maintain or establish separate lines of progression, seniority...

36 CFR § 1211.520 - Job classification and structure.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or... as being for males or for females; (b) Maintain or establish separate lines of progression, seniority...

36 CFR 1211.520 - Job classification and structure.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or... as being for males or for females; (b) Maintain or establish separate lines of progression, seniority...

36 CFR 1211.520 - Job classification and structure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or... as being for males or for females; (b) Maintain or establish separate lines of progression, seniority...

36 CFR 1211.520 - Job classification and structure.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or... as being for males or for females; (b) Maintain or establish separate lines of progression, seniority...

A Preliminary Examination of a General Social Outcome Measure

ERIC Educational Resources Information Center

Stichter, Janine Peck; Herzog, Melissa J.; O'Connor, Karen V.; Schmidt, Carla

2012-01-01

Individuals with Pervasive Developmental Disorders (PDD) have social competence impairments that can result in negative adult outcomes. Despite considerable research on social skills training, little is available to evaluate these programs. This study describes the development, administration, and utility of a progress-monitoring tool for…

50 CFR 223.210 - North American green sturgeon.

Code of Federal Regulations, 2012 CFR

2012-10-01

... out the activity submit progress reports that include the total number of Southern DPS fish taken... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Restrictions... sources, and a point of contact is reported to the NMFS Southwest Regional Office in Long Beach at least...

50 CFR 223.210 - North American green sturgeon.

Code of Federal Regulations, 2010 CFR

2010-10-01

... out the activity submit progress reports that include the total number of Southern DPS fish taken... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Restrictions... sources, and a point of contact is reported to the NMFS Southwest Regional Office in Long Beach at least...

50 CFR 223.210 - North American green sturgeon.

Code of Federal Regulations, 2011 CFR

2011-10-01

... out the activity submit progress reports that include the total number of Southern DPS fish taken... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Restrictions... sources, and a point of contact is reported to the NMFS Southwest Regional Office in Long Beach at least...

The 1996 NAEP Technical Report.

ERIC Educational Resources Information Center

Allen, Nancy L.; Carlson, James E.; Zelenak, Christine A.

This report documents the design, administration, and data analysis procedure of the National Assessment of Education Progress (NAEP) for 1996. It indicates the technical decisions that were made and the rationale behind them. Detailed substantive findings are not presented in this report. These chapters provide technical information about the…

Community College Academic Integrity Lessons That Put Research into Practice

ERIC Educational Resources Information Center

Bealle, Penny

2017-01-01

Academic integrity is an educational issue requiring an educational response from all stakeholders, including faculty, students, librarians, learning support staff, and administrators. This article posits that an educational response at Suffolk County Community College (SCCC) advances progress toward an integrated academic integrity strategy at…

Penal Innovation in New Zealand: He Ara Hou.

ERIC Educational Resources Information Center

Newbold, Greg; Eskridge, Chris

1994-01-01

Explores prison history/development in New Zealand, focusing on recent implementation of progressive prison operation/management program, He Ara Hou. Notes extremely positive results of program, such as higher administrative efficiency; greatly decreased levels of internal disorder; competent, stable workforce; and human product whose senses of…

Structural damage to periodontal tissues at varying rate of anesthetic injection.

PubMed

Sarapultseva, Maria; Sarapultsev, Alexey; Medvedeva, Svetlana; Danilova, Irina

2018-04-01

Incorrect administration of an anesthetic during local anesthesia is one of the most important causes of pain symptoms in patients scheduled for dental procedures. The current study assessed the severity of damage to periodontal tissue following different rates of anesthetic administration. The research was conducted on 50 outbred male rats with a body mass of 180-240 g. The anesthetic used was 1% articaine. The results showed that administration of the anesthetic at a rapid pace caused structural damage to the periodontal tissue. Further, signs of impaired microcirculation were noted at all rates of administration. Biochemical studies demonstrated changes in the level of glucose and enzymes with the rapid introduction of the anesthetic, indicating severe systemic stress response of the body. Injection of local anesthetic at any rate of introduction induces vascular congestion in the microcirculatory bloodstream and exudative reactions. Rapid introduction of an anesthetic causes progression of structural changes in the gingival tissue.

M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice.

PubMed

Seth, Ratanesh Kumar; Das, Suvarthi; Pourhoseini, Sahar; Dattaroy, Diptadip; Igwe, Stephen; Ray, Julie Basu; Fan, Daping; Michelotti, Gregory A; Diehl, Anna Mae; Chatterjee, Saurabh

2015-01-01

Activation of M1 macrophages in nonalcoholic steatohepatitis (NASH) is produced by several external or endogenous factors: inflammatory stimuli, oxidative stress, and cytokines are known. However, any direct role of oxidative stress in causing M1 polarization in NASH has been unclear. We hypothesized that CYP2E1-mediated oxidative stress causes M1 polarization in experimental NASH, and that nitric oxide (NO) donor administration inhibits CYP2E1-mediated inflammation with concomitant attenuation of M1 polarization. Because CYP2E1 takes center stage in these studies, we used a toxin model of NASH that uses a ligand and a substrate of CYP2E1 for inducing NASH. Subsequently, we used a methionine and choline-deficient diet-induced rodent NASH model where the role of CYP2E1 in disease progression has been shown. Our results show that CYP2E1 causes M1 polarization bias, which includes a significant increase in interleukin-1β (IL-1β) and IL-12 in both models of NASH, whereas CYP2E1-null mice or diallyl sulfide administration prevented it. Administration of gadolinium chloride (GdCl3), a macrophage toxin, attenuated both the initial M1 response and the subsequent M2 response, showing that the observed increase in cytokine levels is primarily from macrophages. Based on the evidence of an adaptive NO increase, the NO donor administration in vivo that mechanistically inhibited CYP2E1 catalyzed the oxidative stress during the entire study in NASH-abrogated M1 polarization and NASH progression. The results obtained show the association of CYP2E1 in M1 polarization, and that inhibition of CYP2E1 catalyzed oxidative stress by an NO donor (DETA NONOate [(Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate]) can be a promising therapeutic strategy in NASH. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.

M1 Polarization Bias and Subsequent Nonalcoholic Steatohepatitis Progression Is Attenuated by Nitric Oxide Donor DETA NONOate via Inhibition of CYP2E1-Induced Oxidative Stress in Obese Mice

PubMed Central

Seth, Ratanesh Kumar; Das, Suvarthi; Pourhoseini, Sahar; Dattaroy, Diptadip; Igwe, Stephen; Ray, Julie Basu; Fan, Daping; Michelotti, Gregory A.; Diehl, Anna Mae

2015-01-01

Activation of M1 macrophages in nonalcoholic steatohepatitis (NASH) is produced by several external or endogenous factors: inflammatory stimuli, oxidative stress, and cytokines are known. However, any direct role of oxidative stress in causing M1 polarization in NASH has been unclear. We hypothesized that CYP2E1-mediated oxidative stress causes M1 polarization in experimental NASH, and that nitric oxide (NO) donor administration inhibits CYP2E1-mediated inflammation with concomitant attenuation of M1 polarization. Because CYP2E1 takes center stage in these studies, we used a toxin model of NASH that uses a ligand and a substrate of CYP2E1 for inducing NASH. Subsequently, we used a methionine and choline–deficient diet-induced rodent NASH model where the role of CYP2E1 in disease progression has been shown. Our results show that CYP2E1 causes M1 polarization bias, which includes a significant increase in interleukin-1β (IL-1β) and IL-12 in both models of NASH, whereas CYP2E1-null mice or diallyl sulfide administration prevented it. Administration of gadolinium chloride (GdCl3), a macrophage toxin, attenuated both the initial M1 response and the subsequent M2 response, showing that the observed increase in cytokine levels is primarily from macrophages. Based on the evidence of an adaptive NO increase, the NO donor administration in vivo that mechanistically inhibited CYP2E1 catalyzed the oxidative stress during the entire study in NASH-abrogated M1 polarization and NASH progression. The results obtained show the association of CYP2E1 in M1 polarization, and that inhibition of CYP2E1 catalyzed oxidative stress by an NO donor (DETA NONOate [(Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate]) can be a promising therapeutic strategy in NASH. PMID:25347994

The magnetohydrodynamics coal-fired flow facility

NASA Astrophysics Data System (ADS)

1995-01-01

In this quarterly technical progress report, UTSI reports on the status of a multitask contract to develop the technology for the steam bottoming portion of a MHD Steam Combined Cycle Power Plant. The report describes the facility maintenance and environmental work completed, status of completing technical reports and certain key administrative actions occurring during the quarter. With program resources at a minimum to closeout the MHD program, no further testing occurred during the quarter, but the DOE CFFF facility was maintained in a standby status with winterization, preventive maintenance and repairs accomplished as needed. Plans and preparations progressed for environmental actions needed at the site to investigate and characterize the groundwater and for removal/disposal of asbestos in the cooling tower. Work continued to progress on archiving the results of the MHD program.

Task 10 - technology development integration. Semi-annual report, April 1--September 30, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendrikson, J.G.; Daly, D.J.

1997-05-01

The Energy and Environmental Research Center (EERC), in conjunction with the Waste Policy Institute (WPI), will identify and integrate new technologies to meet site-specific environmental management (EM) requirements at contaminated sites appropriate to U.S. Department of Energy (DOE) interests. This paper briefly reports overall progress for three activities: technology management, project management, and technology integration. Work performed over the reporting period has focused on providing logistical and administrative support. In addition, six monthly WPI reports to the EERC are included as appendices. The WPI reports contained detailed information for progress in each activity.

[Research progress on wetland ecotourism].

PubMed

Wang, Li-Long; Lu, Lin

2009-06-01

Wetland is rich in biodiversity and cultural diversity, possessing higher tourism value and environmental education and community participation functions. Wetland ecotourism reflects the sustainable development of tourism economy and wetland protection, having received great concern from governments and scholars at home and abroad. This paper summarized the related theories and practices, discussed the research advances in wetland ecotourism from the aspects of significance, progress, contents, methods and results, and pointed out the important research fields in the future, aimed to accelerate the development of wetland ecotourism research and to provide reference about the resources exploitation, environment protection, and scientific administration of wetland and related scenic areas.

Shared Decisions & Technology-Assisted Learning

ERIC Educational Resources Information Center

Jacobs, Mary

2005-01-01

In this short article, the author discusses how Henderson Middle School in Jackson, Georgia used shared decision making to improve student achievement through the use of laptop computers. With effective use of technology and shared decision making, administrators at Henderson believe that they can continue to achieve Adequate Yearly Progress under…

Vulnerable Consumers in a Highly Developed Asian Economy: The Case of Japan.

ERIC Educational Resources Information Center

Morita, Yoko; Mieno, Yoshiko; Ikeda, Michiyo; Ogawa, Ikuko

2000-01-01

Presents a survey of the administrative system of consumer protection in Japan and the present state of affairs for consumers. Indicates that progress in advancing consumer protection policies is advancing, but the government has been slow to react to problems and adopt remedies or adjustments. (JOW)

10 CFR 603.805 - Payment methods.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Payment methods. 603.805 Section 603.805 Energy DEPARTMENT... Other Administrative Matters Payments § 603.805 Payment methods. A TIA may provide for: (a... progress. A fixed-support TIA must use this payment method (this does not preclude use of an initial...

10 CFR 603.805 - Payment methods.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Payment methods. 603.805 Section 603.805 Energy DEPARTMENT... Other Administrative Matters Payments § 603.805 Payment methods. A TIA may provide for: (a... progress. A fixed-support TIA must use this payment method (this does not preclude use of an initial...

10 CFR 603.805 - Payment methods.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Payment methods. 603.805 Section 603.805 Energy DEPARTMENT... Other Administrative Matters Payments § 603.805 Payment methods. A TIA may provide for: (a... progress. A fixed-support TIA must use this payment method (this does not preclude use of an initial...