Science.gov

Sample records for promote threshold-like shifts

  1. Experimental observations of the threshold-like onset of mode instabilities in high power fiber amplifiers.

    PubMed

    Eidam, Tino; Wirth, Christian; Jauregui, Cesar; Stutzki, Fabian; Jansen, Florian; Otto, Hans-Jürgen; Schmidt, Oliver; Schreiber, Thomas; Limpert, Jens; Tünnermann, Andreas

    2011-07-04

    We report on the observation and experimental characterization of a threshold-like onset of mode instabilities, i.e. an apparently random relative power content change of different transverse modes, occurring in originally single-mode high-power fiber amplifiers. Although the physical origin of this effect is not yet fully understood, we discuss possible explanations. Accordingly, several solutions are proposed in this paper to raise the threshold of this effect.

  2. How Citation Boosts Promote Scientific Paradigm Shifts and Nobel Prizes

    PubMed Central

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-01-01

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the “boosting effect” of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying “boost factor” is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract. PMID:21573229

  3. How citation boosts promote scientific paradigm shifts and nobel prizes.

    PubMed

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-05-04

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the "boosting effect" of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying "boost factor" is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract.

  4. [Promotion of home shifts for terminal cancer patients through intervention of visitor palliative care team].

    PubMed

    Shiraishi, Ko; Chigira, Mayumi; Tsuyuki, Naoko; Hozaki, Kyoko; Murotsu, Keizo; Umeki, Mikiko; Harada, Naohiro; Hirata, Satomi; Otsuka, Yuko; Hara, Hiroko

    2013-12-01

    It has been recommended that terminal cancer patients be shifted from the hospital to their homes. In our hospital, a visitor palliative care team was started for the purpose of the early introduction of palliative care, and home shifts were promoted. The results of home shifts by the visitor palliative care team from 2008 to 2012 were examined. Home shifts were possible for 27 cases out of 108 cases intervened. In 12 cases, there were at-home deaths, and the median at-home period was 55 days. In the group that could not be shifted, the at-home death rate and application rate of nursing care insurance were low. Additionally, the length of stay (median) for patients who died in hospitalization was 8 days for the group that could be shifted and 17 days for the group that could not be shifted. It was felt that effective communication with local health care facilities is important for a successful home shift. Early and adequate preparations for the treatment and care of terminal cancer patients undergoing home shift are important, and in this regard, a review of the current provisions of nursing care insurance is necessary.

  5. Are insights from Indigenous health shaping a paradigm shift in health promotion praxis in Australia?

    PubMed

    Crouch, Alan; Fagan, Patricia

    2014-01-01

    Health promotion really is at a cross-road. Traditionally guided by the Ottawa Charter, it has been thought of as principle-guided actions, processes and technique, as well as outcomes or results. Health promotion has been characterised by its products and some even call it theory. In Australia, public funding for health promotion has, for many years, shaped its practice into behaviour change interventions. However, governments around the country are reconsidering their investments, evidenced by ideologically motivated policy shifts and associated substantial funding cuts. Recently, themes of empowerment, community control and community agency have emerged as new directions for future health promotion praxis and reports of activism-based approaches that seek to mobilise community energies around sexual health inequity have started to appear in the literature. Noting parallel developments in the social determinants and social change discourses, this paper posits that cutting edge health promotion efforts by Indigenous communities in Australia are shaping a new approach with potentially global application.

  6. Light adaptation increases response latency of alpha ganglion cells via a threshold-like nonlinearity.

    PubMed

    Chang, L; He, S

    2014-01-03

    Adaptation is an important process of sensory systems to adjust sensitivity to ensure the appropriate information encoding. Sensitivity and kinetics of retinal ganglion cell (RGC) responses have been studied extensively using a brief flash superimposed on different but steady backgrounds. However, it is still unclear if light adaptation exerts any effect on more complex response properties, such as response nonlinearity. In this study, we found that the latency of spike responses to a repeated flashing spot stimulation increased by 30 ms in the mouse ON α RGCs (An ON-type RGC is excited when a spot is turned on in the center of its receptive field). A single dimming event preceding the test flash on a steady adapting background could also produce similar effect in increasing latency of light responses. A simple computational model with a linear transformation of the light stimulus and a threshold-like nonlinearity could account for the experimental data. Moreover, the strength of the measured nonlinearity and the response latency were affected by the duration of light adaptation. The possible biological processes underlying this nonlinearity were explored. Voltage clamp recording revealed the presence of the increase in latency and threshold-like nonlinearity in the excitatory input of RGCs. However, no comparable nonlinearity was observed in the light responses of the ON cone bipolar cells. We further excluded GABAergic and glycinergic inhibition, N-methyl-D-aspartate receptor rectification and voltage-gated Na(+) channels as potential sources of this nonlinearity by pharmacological experiments. Our results indicate the bipolar cell terminals as the potential site of nonlinearity. Computational modeling constrained by experimental data supports that conclusion and suggests the voltage-sensitive Ca(++) channels and Ca(++)-dependent vesicle release in the bipolar cell terminals as mechanistic basis.

  7. Biochar Treatment Resulted in a Combined Effect on Soybean Growth Promotion and a Shift in Plant Growth Promoting Rhizobacteria

    PubMed Central

    Egamberdieva, Dilfuza; Wirth, Stephan; Behrendt, Undine; Abd_Allah, Elsayed F.; Berg, Gabriele

    2016-01-01

    The application of biochar to soil is considered to have the potential for long-term soil carbon sequestration, as well as for improving plant growth and suppressing soil pathogens. In our study we evaluated the effect of biochar on the plant growth of soybeans, as well as on the community composition of root-associated bacteria with plant growth promoting traits. Two types of biochar, namely, maize biochar (MBC), wood biochar (WBC), and hydrochar (HTC) were used for pot experiments to monitor plant growth. Soybean plants grown in soil amended with HTC char (2%) showed the best performance and were collected for isolation and further characterization of root-associated bacteria for multiple plant growth promoting traits. Only HTC char amendment resulted in a statistically significant increase in the root and shoot dry weight of soybeans. Interestingly, rhizosphere isolates from HTC char amended soil showed higher diversity than the rhizosphere isolates from the control soil. In addition, a higher proportion of isolates from HTC char amended soil compared with control soil was found to express plant growth promoting properties and showed antagonistic activity against one or more phytopathogenic fungi. Our study provided evidence that improved plant growth by biochar incorporation into soil results from the combination of a direct effect that is dependent on the type of char and a microbiome shift in root-associated beneficial bacteria. PMID:26941730

  8. Biochar Treatment Resulted in a Combined Effect on Soybean Growth Promotion and a Shift in Plant Growth Promoting Rhizobacteria.

    PubMed

    Egamberdieva, Dilfuza; Wirth, Stephan; Behrendt, Undine; Abd Allah, Elsayed F; Berg, Gabriele

    2016-01-01

    The application of biochar to soil is considered to have the potential for long-term soil carbon sequestration, as well as for improving plant growth and suppressing soil pathogens. In our study we evaluated the effect of biochar on the plant growth of soybeans, as well as on the community composition of root-associated bacteria with plant growth promoting traits. Two types of biochar, namely, maize biochar (MBC), wood biochar (WBC), and hydrochar (HTC) were used for pot experiments to monitor plant growth. Soybean plants grown in soil amended with HTC char (2%) showed the best performance and were collected for isolation and further characterization of root-associated bacteria for multiple plant growth promoting traits. Only HTC char amendment resulted in a statistically significant increase in the root and shoot dry weight of soybeans. Interestingly, rhizosphere isolates from HTC char amended soil showed higher diversity than the rhizosphere isolates from the control soil. In addition, a higher proportion of isolates from HTC char amended soil compared with control soil was found to express plant growth promoting properties and showed antagonistic activity against one or more phytopathogenic fungi. Our study provided evidence that improved plant growth by biochar incorporation into soil results from the combination of a direct effect that is dependent on the type of char and a microbiome shift in root-associated beneficial bacteria.

  9. Abstinence promotion under PEPFAR: the shifting focus of HIV prevention for youth.

    PubMed

    Santelli, John S; Speizer, Ilene S; Edelstein, Zoe R

    2013-01-01

    Abstinence-until-marriage (AUM) - strongly supported by religious conservatives in the USA - became a key element of initial human immunodeficiency virus (HIV) prevention efforts under the President's Emergency Plan for AIDS Relief (PEPFAR). AUM programmes have demonstrated limited efficacy in changing behaviours, promoted medically inaccurate information and withheld life-saving information about risk reduction. A focus on AUM also undermined national efforts in Africa to create integrated youth HIV prevention programmes. PEPFAR prevention efforts after 2008 shifted to science-based programming, however, vestiges of AUM remain. Primary prevention programmes within PEPFAR are essential and nations must be able to design HIV prevention based on local needs and prevention science.

  10. "Making it personal": ideology, the arts, and shifting registers in health promotion.

    PubMed

    Ruthven, Jessica S

    2016-01-01

    In South Africa, health promotion related to HIV/AIDS has been characterised as a component of public health prevention. It has heavily utilised global health ideology to construct promotional messages that rely on neoliberal models of individual, responsible health citizenship. However, after nearly 30 years of public health messaging, there have been only minor shifts in the country's HIV prevalence rates; it has become apparent that there is disconnect between policy, programmes, and target audiences. Debates about where this disconnect occurs tend to focus on the role of problems in biomedical knowledge translation or with structural inequalities that lead to health inequity. As debates increase, artists involved in health have emerged to address an additional reason: audience interpellation. In this article, I interrogate relationships between health promotion ideology and processes of interpellation. I suggest that disconnect between the two has roots in the tone of programming, the ways sociality is constructed within health promotion, and the kind of subject which global prevention programmes seek to constitute. Using a case study, I illustrate how public health ideology is made actionable through arts practice. While conventional health promotion programmes address populations in a way that allows individuals to distance themselves, members of South Africa's arts sector have worked to integrate prevention and care in a way that bolsters interpellation through making messages personal. The case study presents one performance but is informed by my broader research with over 20 theatrical groups conducted during 18 months of fieldwork. Analysis of the production reveals that artists act as mediators between population-level public health messages and individuals through the embodied technologies of applied theatre. However, I argue that artists also create space for participants to reimagine configurations of care, responsibility, and intimacy within health

  11. Abstinence Promotion Under PEPFAR: The Shifting Focus of HIV Prevention For Youth

    PubMed Central

    Santelli, John S.; Speizer, Ilene S.; Edelstein, Zoe R.

    2013-01-01

    Abstinence-until-marriage (AUM) – strongly supported by religious conservatives in the U.S. - became a key element of initial HIV prevention efforts under the President’s Emergency Plan for AIDS Relief (PEPFAR). AUM programs have demonstrated limited efficacy in changing behaviors, promoted medically inaccurate information, and withheld life-saving information about risk reduction. A focus on AUM also undermined national efforts in Africa to create integrated youth HIV prevention programs. PEPFAR prevention efforts after 2008 shifted to science-based programming, however vestiges of AUM remain. Primary prevention programs within PEPFAR are essential and nations must be able to design HIV prevention based on local needs and prevention science. PMID:23327516

  12. Eocene habitat shift from saline to freshwater promoted Tethyan amphipod diversification.

    PubMed

    Hou, Zhonge; Sket, Boris; Fiser, Cene; Li, Shuqiang

    2011-08-30

    Current theory predicts that a shift to a new habitat would increase the rate of diversification, while as lineages evolve into multiple species, intensified competition would decrease the rate of diversification. We used Holarctic amphipods of the genus Gammarus to test this hypothesis. We sequenced four genes (5,088 bp) for 289 samples representing 115 Gammarus species. A phylogenetic analysis showed that Gammarus originated from the Tethyan region with a saline ancestry in the Paleocene, and later colonized the freshwater habitat in the Middle Eocene. Ancestral range reconstruction and diversification mode analysis combined with paleogeological and paleoclimatic evidence suggested that the habitat shift from saline to freshwater led to an increased diversification rate. The saline lineage of Gammarus dispersed to both sides of the Atlantic at 55 million years ago (Ma), because of the few barriers between the Tethys and the Atlantic, and diversified throughout its evolutionary history with a constant diversification rate [0.04 species per million years (sp/My)]. The freshwater Gammarus, however, underwent a rapid diversification phase (0.11 sp/My) until the Middle Miocene, and lineages successively diversified across Eurasia via vicariance process likely driven by changes of the Tethys and landmass. In particular, the freshwater Gammarus lacustris and Gammarus balcanicus lineages had a relatively high diversification shift, corresponding to the regression of the Paratethys Sea and the continentalization of Eurasian lands during the Miocene period. Subsequently (14 Ma), the diversification rate of the freshwater Gammarus decreased to 0.05 and again to 0.01 sp/My. The genus Gammarus provides an excellent aquatic case supporting the hypothesis that ecological opportunities promote diversification.

  13. Threshold-like complexation of conjugated polymers with small molecule acceptors in solution within the neighbor-effect model.

    PubMed

    Sosorev, Andrey Yu; Parashchuk, Olga D; Zapunidi, Sergey A; Kashtanov, Grigoriy S; Golovnin, Ilya V; Kommanaboyina, Srikanth; Perepichka, Igor F; Paraschuk, Dmitry Yu

    2016-02-14

    In some donor-acceptor blends based on conjugated polymers, a pronounced charge-transfer complex (CTC) forms in the electronic ground state. In contrast to small-molecule donor-acceptor blends, the CTC concentration in polymer:acceptor solution can increase with the acceptor content in a threshold-like way. This threshold-like behavior was earlier attributed to the neighbor effect (NE) in the polymer complexation, i.e., next CTCs are preferentially formed near the existing ones; however, the NE origin is unknown. To address the factors affecting the NE, we record the optical absorption data for blends of the most studied conjugated polymers, poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV) and poly(3-hexylthiophene) (P3HT), with electron acceptors of fluorene series, 1,8-dinitro-9,10-antraquinone (), and 7,7,8,8-tetracyanoquinodimethane () in different solvents, and then analyze the data within the NE model. We have found that the NE depends on the polymer and acceptor molecular skeletons and solvent, while it does not depend on the acceptor electron affinity and polymer concentration. We conclude that the NE operates within a single macromolecule and stems from planarization of the polymer chain involved in the CTC with an acceptor molecule; as a result, the probability of further complexation with the next acceptor molecules at the adjacent repeat units increases. The steric and electronic microscopic mechanisms of NE are discussed.

  14. Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin.

    PubMed

    Kim, Hyeun Bum; Borewicz, Klaudyna; White, Bryan A; Singer, Randall S; Sreevatsan, Srinand; Tu, Zheng Jin; Isaacson, Richard E

    2012-09-18

    Antimicrobials have been used extensively as growth promoters (AGPs) in agricultural animal production. However, the specific mechanism of action for AGPs has not yet been determined. The work presented here was to determine and characterize the microbiome of pigs receiving one AGP, tylosin, compared with untreated pigs. We hypothesized that AGPs exerted their growth promoting effect by altering gut microbial population composition. We determined the fecal microbiome of pigs receiving tylosin compared with untreated pigs using pyrosequencing of 16S rRNA gene libraries. The data showed microbial population shifts representing both microbial succession and changes in response to the use of tylosin. Quantitative and qualitative analyses of sequences showed that tylosin caused microbial population shifts in both abundant and less abundant species. Our results established a baseline upon which mechanisms of AGPs in regulation of health and growth of animals can be investigated. Furthermore, the data will aid in the identification of alternative strategies to improve animal health and consequently production.

  15. Practical interventions to promote circadian adaptation to permanent night shift work: study 4.

    PubMed

    Smith, Mark R; Fogg, Louis F; Eastman, Charmane I

    2009-04-01

    Scheduled bright light and darkness can phase shift the circadian clocks of night workers for complete adaptation to a night work, day sleep schedule, but few night workers would want this because it would leave them out of phase with the diurnal world on days off. This is the final study in a series designed to produce a compromise circadian phase position for permanent night shift work in which the sleepiest circadian time is delayed out of the night work period and into the first half of the day sleep episode. The target compromise phase position was a dim light melatonin onset (DLMO) of 3:00, which puts the sleepiest circadian time at approximately 10:00. This was predicted to improve night shift alertness and performance while permitting sufficient daytime sleep after work as well as late-night sleep on days off. In a between-subjects design, 19 healthy subjects underwent 3 simulated night shifts (23:00-7:00), 2 days off, 4 more night shifts, and 2 more days off. Subjects "worked" in the lab and slept at home. Experimental subjects received four 15-min bright light pulses during each night shift, wore dark sunglasses when outside, slept in dark bedrooms at scheduled times, and received outdoor afternoon light exposure ("light brake") to keep their rhythms from delaying too far. Control subjects remained in normal room light during night shifts, wore lighter sunglasses, and had unrestricted sleep and outdoor light exposure. The final DLMO of the experimental group was 3:22 +/- 2.0 h, close to the target of 3:00, and later than the control group at 23:24 +/- 3.8 h. Experimental subjects slept for nearly all the permitted time in bed. Some control subjects who slept late on weekends also reached the compromise phase position and obtained more daytime sleep. Subjects who phase delayed (whether in the experimental or control group) close to the target phase performed better during night shifts. A compromise circadian phase position improved performance during night

  16. Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota

    PubMed Central

    Bishehsari, Faraz; Saadalla, Abdulrahman; Khazaie, Khashayarsha; Engen, Phillip A.; Voigt, Robin M.; Shetuni, Brandon B.; Forsyth, Christopher; Shaikh, Maliha; Vitaterna, Martha Hotz; Turek, Fred; Keshavarzian, Ali

    2016-01-01

    Background: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption—a frequent habit of majority of modern societies—increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption—another modern life style habit—in promoting alcohol-associated CRC. Method: TS4Cre × adenomatous polyposis coli (APC)lox468 mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle. Mice were sacrificed after eight weeks of full alcohol and/or LD shift to collect intestine samples. Tumor number, size, and histologic grades were compared between animal groups. Mast cell protease 2 (MCP2) and 6 (MCP6) histology score were analyzed and compared. Stool collected at baseline and after four weeks of experimental manipulations was used for microbiota analysis. Results: The combination of alcohol and LD shifting accelerated intestinal polyposis, with a significant increase in polyp size, and caused advanced neoplasia. Consistent with a pathogenic role of stromal tryptase-positive mast cells in colon carcinogenesis, the ratio of mMCP6 (stromal)/mMCP2 (intraepithelial) mast cells increased upon LD shifting. Baseline microbiota was similar between groups, and experimental manipulations resulted in a significant difference in the microbiota composition between groups. Conclusions: Circadian disruption by Light:dark shifting exacerbates alcohol-induced polyposis and CRC. Effect of circadian disruption could, at least partly, be mediated by promoting a pro-tumorigenic inflammatory milieu via changes in microbiota. PMID:27918452

  17. Identifying Teacher Needs for Promoting Education through Science as a Paradigm Shift in Science Education

    ERIC Educational Resources Information Center

    Holbrook, J.; Rannikmae, M.; Valdmann, A.

    2014-01-01

    This paper identifies an "education through science" philosophy for school science teaching at the secondary level and determines its interrelationship with approaches to student acquisition of key educational competences and the identification of teacher needs to promote meaningful learning during science lessons. Based on the…

  18. Bacterial Community Shift Drives Antibiotic Resistance Promotion during Drinking Water Chlorination.

    PubMed

    Jia, Shuyu; Shi, Peng; Hu, Qing; Li, Bing; Zhang, Tong; Zhang, Xu-Xiang

    2015-10-20

    For comprehensive insights into the effects of chlorination, a widely used disinfection technology, on bacterial community and antibiotic resistome in drinking water, this study applied high-throughput sequencing and metagenomic approaches to investigate the changing patterns of antibiotic resistance genes (ARGs) and bacterial community in a drinking water treatment and distribution system. At genus level, chlorination could effectively remove Methylophilus, Methylotenera, Limnobacter, and Polynucleobacter, while increase the relative abundance of Pseudomonas, Acidovorax, Sphingomonas, Pleomonas, and Undibacterium in the drinking water. A total of 151 ARGs within 15 types were detectable in the drinking water, and chlorination evidently increased their total relative abundance while reduced their diversity in the opportunistic bacteria (p < 0.05). Residual chlorine was identified as the key contributing factor driving the bacterial community shift and resistome alteration. As the dominant persistent ARGs in the treatment and distribution system, multidrug resistance genes (mainly encoding resistance-nodulation-cell division transportation system) and bacitracin resistance gene bacA were mainly carried by chlorine-resistant bacteria Pseudomonas and Acidovorax, which mainly contributed to the ARGs abundance increase. The strong correlation between bacterial community shift and antibiotic resistome alteration observed in this study may shed new light on the mechanism behind the chlorination effects on antibiotic resistance.

  19. Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators

    PubMed Central

    Kalish, Brian T.; Le, Hau D.; Fitzgerald, Jonathan M.; Wang, Samantha; Seamon, Kyle; Gura, Kathleen M.; Gronert, Karsten

    2013-01-01

    Parenteral nutrition (PN)-associated liver disease (PNALD) is a life-threatening complication of the administration of PN. The development of PNALD may be partly due to the composition of the lipid emulsion administered with PN: soybean oil-based lipid emulsions (SOLE) are associated with liver disease, while fish oil-based lipid emulsions (FOLE) are associated with prevention and improvement of liver disease. The objective of this study was to determine how the choice of lipid emulsion modified the production of bioactive lipid mediators (LMs). We utilized a mouse model of steatosis to study the differential effect of FOLE and SOLE. We subsequently validated these results in serum samples from a small cohort of human infants transitioning from SOLE to FOLE. In mice, FOLE was associated with production of anti-inflammatory, proresolving LMs; SOLE was associated with increased production of inflammatory LMs. In human infants, the transition from SOLE to FOLE was associated with a shift toward a proresolving lipidome. Together, these results demonstrate that the composition of the lipid emulsion directly modifies inflammatory homeostasis. PMID:24091595

  20. Tandem processes promoted by a hydrogen shift in 6-arylfulvenes bearing acetalic units at ortho position: a combined experimental and computational study

    PubMed Central

    Alajarin, Mateo; Marin-Luna, Marta; Vidal, Angel

    2016-01-01

    Summary 6-Phenylfulvenes bearing (1,3-dioxolan or dioxan)-2-yl substituents at ortho position convert into mixtures of 4- and 9-(hydroxy)alkoxy-substituted benz[f]indenes as result of cascade processes initiated by a thermally activated hydrogen shift. Structurally related fulvenes with non-cyclic acetalic units afforded mixtures of 4- and 9-alkoxybenz[f]indenes under similar thermal conditions. Mechanistic paths promoted by an initial [1,4]-, [1,5]-, [1,7]- or [1,9]-H shift are conceivable for explaining these conversions. Deuterium labelling experiments exclude the [1,4]-hydride shift as the first step. A computational study scrutinized the reaction channels of these tandem conversions starting by [1,5]-, [1,7]- and [1,9]-H shifts, revealing that this first step is the rate-determining one and that the [1,9]-H shift is the one with the lowest energy barrier. PMID:26977185

  1. Fire-induced pine woodland to shrubland transitions in Southern Europe may promote shifts in soil fertility.

    PubMed

    Mayor, A G; Valdecantos, A; Vallejo, V R; Keizer, J J; Bloem, J; Baeza, J; González-Pelayo, O; Machado, A I; de Ruiter, P C

    2016-12-15

    Since the mid of the last century, fire recurrence has increased in the Iberian Peninsula and in the overall Mediterranean basin due to changes in land use and climate. The warmer and drier climate projected for this region will further increase the risk of wildfire occurrence and recurrence. Although the impact of wildfires on soil nutrient content in this region has been extensively studied, still few works have assessed this impact on the basis of fire recurrence. This study assesses the changes in soil organic C and nutrient status of mineral soils in two Southern European areas, Várzea (Northern Portugal) and Valencia (Eastern Spain), affected by different levels of fire recurrence and where short fire intervals have promoted a transition from pine woodlands to shrublands. At the short-term (<1year), the amount of soil organic matter was higher in burned than in unburned soils while its quality (represented as labile to total organic matter) was actually lower. In any case, total and labile soil organic matter showed decreasing trends with increasing fire recurrence (one to four fires). At the long-term (>5years), a decline in overall soil fertility with fire recurrence was also observed, with a drop between pine woodlands (one fire) and shrublands (two and three fires), particularly in the soil microsites between shrubs. Our results suggest that the current trend of increasing fire recurrence in Southern Europe may result in losses or alterations of soil organic matter, particularly when fire promotes a transition from pine woodland to shrubland. The results also point to labile organic matter fractions in the intershrub spaces as potential early warning indicators for shifts in soil fertility in response to fire recurrence.

  2. Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats

    PubMed Central

    Salgado-Delgado, Roberto C.; Saderi, Nadia; Basualdo, María del Carmen; Guerrero-Vargas, Natali N.; Escobar, Carolina; Buijs, Ruud M.

    2013-01-01

    In the liver, clock genes are proposed to drive metabolic rhythms. These gene rhythms are driven by the suprachiasmatic nucleus (SCN) mainly by food intake and via autonomic and hormonal pathways. Forced activity during the normal rest phase, induces also food intake, thus neglecting the signals of the SCN, leading to conflicting time signals to target tissues of the SCN. The present study explored in a rodent model of night-work the influence of food during the normal sleep period on the synchrony of gene expression between clock genes and metabolic genes in the liver. Male Wistar rats were exposed to forced activity for 8 h either during the rest phase (day) or during the active phase (night) by using a slow rotating wheel. In this shift work model food intake shifts spontaneously to the forced activity period, therefore the influence of food alone without induced activity was tested in other groups of animals that were fed ad libitum, or fed during their rest or active phase. Rats forced to be active and/or eating during their rest phase, inverted their daily peak of Per1, Bmal1 and Clock and lost the rhythm of Per2 in the liver, moreover NAMPT and metabolic genes such as Pparα lost their rhythm and thus their synchrony with clock genes. We conclude that shift work or food intake in the rest phase leads to desynchronization within the liver, characterized by misaligned temporal patterns of clock genes and metabolic genes. This may be the cause of the development of the metabolic syndrome and obesity in individuals engaged in shift work. PMID:23565183

  3. Dimeric rare-earth BINOLate complexes: activation of 1,4-benzoquinone through Lewis acid promoted potential shifts.

    PubMed

    Robinson, Jerome R; Booth, Corwin H; Carroll, Patrick J; Walsh, Patrick J; Schelter, Eric J

    2013-05-03

    Reaction of p-benzoquinone (BQ) with a series of rare-earth metal/alkali metal/1,1'-BINOLate (REMB) complexes (RE: La, Ce, Pr, Nd; M: Li) results in the largest recorded shift in reduction potential observed for BQ upon complexation. In the case of cerium, the formation of a 2:1 Ce/BQ complex shifts the two-electron reduction of BQ by greater than or equal to 1.6 V to a more favorable potential. Reactivity investigations were extended to other RE(III) (RE = La, Pr, Nd) complexes where the resulting highly electron-deficient quinone ligands afforded isolation of the first lanthanide quinhydrone-type charge-transfer complexes. The large reduction-potential shift associated with the formation of 2:1 Ce/BQ complexes illustrate the potential of Ce complexes to function both as a Lewis acid and an electron source in redox chemistry and organic-substrate activation.

  4. Promotion

    PubMed Central

    Alam, Hasan B.

    2013-01-01

    This article gives an overview of the promotion process in an academic medical center. A description of different promotional tracks, tenure and endowed chairs, and the process of submitting an application is provided. Finally, some practical advice about developing skills and attributes that can help with academic growth and promotion is dispensed. PMID:24436683

  5. EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    PubMed

    Carvalho, Samara Camaçari de; Apolinário, Leticia Montanholi; Matheus, Selma Maria Michelin; Santo Neto, Humberto; Marques, Maria Julia

    2013-11-15

    In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulators of M1 (iNOS-expressing cells) and M2 (CD206-expressing cells) macrophages. Mdx mice (14 days old) received EPA or DFZ for 16 days. The diaphragm, biceps brachii and quadriceps muscles were studied. Immunofluorescence, immunoblotting and ELISA assays showed that EPA increased interleucin-10, reduced interferon-γ and was more effective than DFZ in promoting a shift from M1 to M2.

  6. Repeated climate-linked host shifts have promoted diversification in a temperate clade of leaf-mining flies.

    PubMed

    Winkler, Isaac S; Mitter, Charles; Scheffer, Sonja J

    2009-10-27

    A central but little-tested prediction of "escape and radiation" coevolution is that colonization of novel, chemically defended host plant clades accelerates insect herbivore diversification. That theory, in turn, exemplifies one side of a broader debate about the relative influence on clade dynamics of intrinsic (biotic) vs. extrinsic (physical-environmental) forces. Here, we use a fossil-calibrated molecular chronogram to compare the effects of a major biotic factor (repeated shift to a chemically divergent host plant clade) and a major abiotic factor (global climate change) on the macroevolutionary dynamics of a large Cenozoic radiation of phytophagous insects, the leaf-mining fly genus Phytomyza (Diptera: Agromyzidae). We find one of the first statistically supported examples of consistently elevated net diversification accompanying shift to new plant clades. In contrast, we detect no significant direct effect on diversification of major global climate events in the early and late Oligocene. The broader paleoclimatic context strongly suggests, however, that climate change has at times had a strong indirect influence through its effect on the biotic environment. Repeated rapid Miocene radiation of these flies on temperate herbaceous asterids closely corresponds to the dramatic, climate-driven expansion of seasonal, open habitats.

  7. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis.

    PubMed

    Zhang, J; Gao, Q; Zhou, Y; Dier, U; Hempel, N; Hochwald, S N

    2016-04-14

    Cancer cells often gains a growth advantage by taking up glucose at a high rate and undergoing aerobic glycolysis through intrinsic cellular factors that reprogram glucose metabolism. Focal adhesion kinase (FAK), a key transmitter of growth factor and anchorage stimulation, is aberrantly overexpressed or activated in most solid tumors, including pancreatic ductal adenocarcinomas (PDACs). We determined whether FAK can act as an intrinsic driver to promote aerobic glycolysis and tumorigenesis. FAK inhibition decreases and overexpression increases intracellular glucose levels during unfavorable conditions, including growth factor deficiency and cell detachment. Amplex glucose assay, fluorescence and carbon-13 tracing studies demonstrate that FAK promotes glucose consumption and glucose-to-lactate conversion. Extracellular flux analysis indicates that FAK enhances glycolysis and decreases mitochondrial respiration. FAK increases key glycolytic proteins, including enolase, pyruvate kinase M2 (PKM2), lactate dehydrogenase and monocarboxylate transporter. Furthermore, active/tyrosine-phosphorylated FAK directly binds to PKM2 and promotes PKM2-mediated glycolysis. On the other hand, FAK-decreased levels of mitochondrial complex I can result in reduced oxidative phosphorylation (OXPHOS). Attenuation of FAK-enhanced glycolysis re-sensitizes cancer cells to growth factor withdrawal, decreases cell viability and reduces growth of tumor xenografts. These observations, for the first time, establish a vital role of FAK in cancer glucose metabolism through alterations in the OXPHOS-to-glycolysis balance. Broadly targeting the common phenotype of aerobic glycolysis and more specifically FAK-reprogrammed glucose metabolism will disrupt the bioenergetic and biosynthetic supply for uncontrolled growth of tumors, particularly glycolytic PDAC.

  8. Novel Comparative Pattern Count Analysis Reveals a Chronic Ethanol-Induced Dynamic Shift in Immediate Early NF-κB Genome-wide Promoter Binding During Liver Regeneration

    PubMed Central

    Kuttippurathu, Lakshmi; Patra, Biswanath; Hoek, Jan B; Vadigepalli, Rajanikanth

    2016-01-01

    Liver regeneration after partial hepatectomy is a clinically important process that is impaired by adaptation to chronic alcohol intake. We focused on the initial time points following partial hepatectomy (PHx) to analyze genome-wide binding activity of NF-κB, a key immediate early regulator. We investigated the effect of chronic alcohol intake on immediate early NF-κB genome-wide localization, in the adapted state as well as in response to partial hepatectomy, using chromatin immunoprecipitation followed by promoter microarray analysis. We found many ethanol-specific NF-κB binding target promoters in the ethanol-adapted state, corresponding to regulation of biosynthetic processes, oxidation-reduction and apoptosis. Partial hepatectomy induced a diet-independent shift in NF-κB binding loci relative to the transcription start sites. We employed a novel pattern count analysis to exhaustively enumerate and compare the number of promoters corresponding to the temporal binding patterns in ethanol and pair-fed control groups. The highest pattern count corresponded to promoters with NF-κB binding exclusively in the ethanol group at 1h post PHx. This set was associated with regulation of cell death, response to oxidative stress, histone modification, mitochondrial function, and metabolic processes. Integration with the global gene expression profiles to identify putative transcriptional consequences of NF-κB binding patterns revealed that several of ethanol-specific 1h binding targets showed ethanol-specific differential expression through 6h post PHx. Motif analysis yielded co-incident binding loci for STAT3, AP-1, CREB, C/EBP-β, PPAR-γ and C/EBP-α, likely participating in co-regulatory modules with NF-κB in shaping the immediate early response to PHx. We conclude that adaptation to chronic ethanol intake disrupts the NF-κB promoter binding landscape with consequences for the immediate early gene regulatory response to the acute challenge of PHx. PMID:26847025

  9. An auxin-mediated shift toward growth isotropy promotes organ formation at the shoot meristem in Arabidopsis.

    PubMed

    Sassi, Massimiliano; Ali, Olivier; Boudon, Frédéric; Cloarec, Gladys; Abad, Ursula; Cellier, Coralie; Chen, Xu; Gilles, Benjamin; Milani, Pascale; Friml, Jiří; Vernoux, Teva; Godin, Christophe; Hamant, Olivier; Traas, Jan

    2014-10-06

    To control morphogenesis, molecular regulatory networks have to interfere with the mechanical properties of the individual cells of developing organs and tissues, but how this is achieved is not well known. We study this issue here in the shoot meristem of higher plants, a group of undifferentiated cells where complex changes in growth rates and directions lead to the continuous formation of new organs. Here, we show that the plant hormone auxin plays an important role in this process via a dual, local effect on the extracellular matrix, the cell wall, which determines cell shape. Our study reveals that auxin not only causes a limited reduction in wall stiffness but also directly interferes with wall anisotropy via the regulation of cortical microtubule dynamics. We further show that to induce growth isotropy and organ outgrowth, auxin somehow interferes with the cortical microtubule-ordering activity of a network of proteins, including AUXIN BINDING PROTEIN 1 and KATANIN 1. Numerical simulations further indicate that the induced isotropy is sufficient to amplify the effects of the relatively minor changes in wall stiffness to promote organogenesis and the establishment of new growth axes in a robust manner.

  10. Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo

    PubMed Central

    Liu, Xiangwei; Tan, Naiwen; Zhou, Yuchao; Zhou, Xueying; Chen, Hui; Wei, Hongbo; Chen, Ji; Xu, Xiaoru; Zhang, Sijia

    2016-01-01

    Adipose mesenchymal stem cells (ASCs) are considered as the promising seed cells for bone regeneration. However, the lower osteogenic differentiation capacity limits its therapeutic efficacy. Identification of the key molecules governing the differences between ASCs and BMSCs would shed light on manipulation of ASCs towards osteogenic phenotype. In this study, we screened semaphorin family members in ASCs and BMSCs and identified Sema3A as an osteogenic semaphorin that was significantly and predominantly expressed in BMSCs. The analyses in vitro showed that the overexpression of Sema3A in ASCs significantly enhanced the expression of bone-related genes and extracellular matrix calcium deposition, while decreasing the expression of adipose-related genes and thus lipid droplet formation, resembling a BMSCs phenotype. Furthermore, Sema3A modified ASCs were then engrafted into poly(lactic-co-glycolic acid) (PLGA) scaffolds to repair the critical-sized calvarial defects in rat model. As expected, Sema3A modified ASCs encapsulation significantly promoted new bone formation with higher bone volume fraction and bone mineral density. Additionally, Sema3A was found to simultaneously increase multiple Wnt related genes and thus activating Wnt pathway. Taken together, our study here identifies Sema3A as a critical gene for osteogenic phenotype and reveals that Sema3A-modified ASCs would serve as a promising candidate for bettering bone defect repair. PMID:27721834

  11. Nanophase Manganese Oxides: Chemisorbed Water and Small Particle Size Promote Large Thermodynamically Driven Shifts in Oxidation-Reduction Equilibria

    NASA Astrophysics Data System (ADS)

    Birkner, N.; Navrotsky, A.

    2011-12-01

    Manganese oxides are important in terrestrial and Martian settings, and changes in oxidation state (Mn 2+, 3+, 4+) produce different phases. This study focuses on changes in redox energetics at the nanoscale in the Mn-O system with water present. Nanophase hausmannite (Mn3O4), bixbyite (Mn2O3), and pyrolusite (MnO2) were synthesized using minor modifications of previously published methods, stored at room temperature, and then analyzed by powder-XRD, BET surface area measurement, and TGA for total water content. High-temperature oxide-melt drop solution calorimetry was performed on a series of characterized samples with known surface area and water content. The differential heat of water adsorption as a function of coverage was also measured. The surface enthalpies of manganese oxide phases, hausmannite (Mn3O4), bixbyite (Mn2O3), and pyrolusite (MnO2), were determined using the data from high-temperature oxide melt calorimetry and water adsorption calorimetry. Surface energy for the hydrous Mn3O4 tetragonal spinel phase is 0.96±0.08 J/m2, for Mn2O3 cubic phase is 1.29±0.10 J/m2, and for MnO2 cubic rutile phase is 1.64±0.10 J/m2. Surface energy for the anhydrous Mn3O4 is 1.31±0.08 J/m2, for Mn2O3 is 1.57±0.10 J/m2, and for MnO2 is 1.99±0.10 J/m2. Supporting preliminary findings, the spinel phase (hausmannite) has a lower surface energy than bixbyite, while the latter has a smaller surface energy than pyrolusite. We also observed phase changes, some of them rapidly reversible, associated with water adsorption/desorption for the nanophase manganese oxide assemblages. There are geochemical consequences. (1) At the nanoscale, both the pyrolusite/bixbyite and bixbyite/hausmannite equilibria are shifted to higher oxygen fugacity because the reduced phase has the lower surface energy. (2) The ready inter-conversion of phases with different oxidation states under aqueous conditions implies that, after a manganese oxide nanophase forms, it can easily transform to other

  12. Shifts in Developmental Timing, and Not Increased Levels of Experience-Dependent Neuronal Activity, Promote Barrel Expansion in the Primary Somatosensory Cortex of Rats Enucleated at Birth

    PubMed Central

    Fetter-Pruneda, Ingrid; Ibarrarán-Viniegra, Ana Sofía; Martínez-Martínez, Eduardo; Sandoval-Velasco, Marcela; Uribe-Figueroa, Laura; Padilla-Cortés, Patricia; Mercado-Célis, Gabriela; Gutiérrez-Ospina, Gabriel

    2013-01-01

    Birth-enucleated rodents display enlarged representations of whiskers (i.e., barrels of the posteromedial subfield) in the primary somatosensory cortex. Although the historical view maintains that barrel expansion is due to incremental increases in neuronal activity along the trigeminal pathway during postnatal development, recent evidence obtained in experimental models of intramodal plasticity challenges this view. Here, we re-evaluate the role of experience-dependent neuronal activity on barrel expansion in birth-enucleated rats by combining various anatomical methods and sensory deprivation paradigms. We show that barrels in birth-enucleated rats were already enlarged by the end of the first week of life and had levels of metabolic activity comparable to those in control rats at different ages. Dewhiskering after the postnatal period of barrel formation did not prevent barrel expansion in adult, birth-enucleated rats. Further, dark rearing and enucleation after barrel formation did not lead to expanded barrels in adult brains. Because incremental increases of somatosensory experience did not promote barrel expansion in birth-enucleated rats, we explored whether shifts of the developmental timing could better explain barrel expansion during the first week of life. Accordingly, birth-enucleated rats show earlier formation of barrels, accelerated growth of somatosensory thalamocortical afferents, and an earlier H4 deacetylation. Interestingly, when H4 deacetylation was prevented with a histone deacetylases inhibitor (valproic acid), barrel specification timing returned to normal and barrel expansion did not occur. Thus, we provide evidence supporting that shifts in developmental timing modulated through epigenetic mechanisms, and not increased levels of experience dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth. PMID:23372796

  13. Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris.

    PubMed

    Wang, Jinjia; Wang, Xiaolong; Shi, Lei; Qi, Fei; Zhang, Ping; Zhang, Yuanxing; Zhou, Xiangshan; Song, Zhiwei; Cai, Menghao

    2017-02-02

    The alcohol oxidase 1 promoter (PAOX1) of Pichia pastoris is commonly used for high level expression of recombinant proteins. While the safety risk of methanol and tough process control for methanol induction usually cause problems especially in large-scale fermentation. By testing the functions of trans-acting elements of PAOX1 and combinatorially engineering of them, we successfully constructed a methanol-free PAOX1 start-up strain, in which, three transcription repressors were identified and deleted and, one transcription activator were overexpressed. The strain expressed 77% GFP levels in glycerol compared to the wide-type in methanol. Then, insulin precursor (IP) was expressed, taking which as a model, we developed a novel glucose-glycerol-shift induced PAOX1 start-up for this methanol-free strain. A batch phase with glucose of 40 g/L followed by controlling residual glucose not lower than 20 g/L was compatible for supporting cell growth and suppressing PAOX1. Then, glycerol induction was started after glucose used up. Accordingly, an optimal bioprocess was further determined, generating a high IP production of 2.46 g/L in a 5-L bioreactor with dramatical decrease of oxygen consumption and heat evolution comparing with the wild-type in methanol. This mutant and bioprocess represent a safe and efficient alternative to the traditional glycerol-repressed/methanol-induced PAOX1 system.

  14. Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris

    PubMed Central

    Wang, Jinjia; Wang, Xiaolong; Shi, Lei; Qi, Fei; Zhang, Ping; Zhang, Yuanxing; Zhou, Xiangshan; Song, Zhiwei; Cai, Menghao

    2017-01-01

    The alcohol oxidase 1 promoter (PAOX1) of Pichia pastoris is commonly used for high level expression of recombinant proteins. While the safety risk of methanol and tough process control for methanol induction usually cause problems especially in large-scale fermentation. By testing the functions of trans-acting elements of PAOX1 and combinatorially engineering of them, we successfully constructed a methanol-free PAOX1 start-up strain, in which, three transcription repressors were identified and deleted and, one transcription activator were overexpressed. The strain expressed 77% GFP levels in glycerol compared to the wide-type in methanol. Then, insulin precursor (IP) was expressed, taking which as a model, we developed a novel glucose-glycerol-shift induced PAOX1 start-up for this methanol-free strain. A batch phase with glucose of 40 g/L followed by controlling residual glucose not lower than 20 g/L was compatible for supporting cell growth and suppressing PAOX1. Then, glycerol induction was started after glucose used up. Accordingly, an optimal bioprocess was further determined, generating a high IP production of 2.46 g/L in a 5-L bioreactor with dramatical decrease of oxygen consumption and heat evolution comparing with the wild-type in methanol. This mutant and bioprocess represent a safe and efficient alternative to the traditional glycerol-repressed/methanol-induced PAOX1 system. PMID:28150747

  15. Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation

    PubMed Central

    WINSHIP, AMY LOUISE; RAINCZUK, KATE; TON, AMANDA; DIMITRIADIS, EVA

    2016-01-01

    Endometrial cancer is the most common invasive gynaecological malignancy. While endocrine, genetic and inflammatory factors are thought to contribute to its pathogenesis, its precise etiology and molecular regulators remain poorly understood. Fibulin-5 is an extracellular matrix (ECM) protein that inhibits cell growth and invasion in several cancer cell types and is downregulated in a number of types of human cancer. However, it is unknown whether fibulin-5 plays a role in endometrial tumourigenesis. In the current report, the expression and localisation of fibulin-5 in type I endometrioid human endometrial cancers of grades (G) 1–3 was investigated using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry. Fibulin-5 mRNA was found to be significantly reduced in whole tumour tissues from women across G1-3 compared with benign endometrium (P<0.0001). Consistently, fibulin-5 protein was also reduced in the tumour epithelial compartment across increasing tumour grades. By contrast, increased protein localisation to the tumour stroma was observed with increasing grade. Knockdown by small interfering RNA in Ishikawa endometrial epithelial cancer cells expressing fibulin-5 stimulated cell adhesion and proliferation in vitro. Fibulin-5 mRNA expression in Ishikawa cells was induced by transforming growth factor-β and fibulin-5 in turn activated extracellular signal-regulated kinases (ERK1/2), suggesting that it may act via the mitogen-activated protein kinase pathway. In summary, the present study identified fibulin-5 as a downregulated ECM gene in human endometrial cancer and observed a shift from epithelial to stromal protein localisation with increasing tumour grade in women. These data suggest that loss of fibulin-5 function may promote endometrial cancer progression by enhancing epithelial cell adhesion and proliferation. PMID:27347195

  16. Antisense inhibition of the plastidial glucose-6-phosphate/phosphate translocator in Vicia seeds shifts cellular differentiation and promotes protein storage.

    PubMed

    Rolletschek, Hardy; Nguyen, Thuy H; Häusler, Rainer E; Rutten, Twan; Göbel, Cornelia; Feussner, Ivo; Radchuk, Ruslana; Tewes, Annegret; Claus, Bernhard; Klukas, Christian; Linemann, Ute; Weber, Hans; Wobus, Ulrich; Borisjuk, Ljudmilla

    2007-08-01

    The glucose-6-phosphate/phosphate translocator (GPT) acts as an importer of carbon into the plastid. Despite the potential importance of GPT for storage in crop seeds, its regulatory role in biosynthetic pathways that are active during seed development is poorly understood. We have isolated GPT1 from Vicia narbonensis and studied its role in seed development using a transgenic approach based on the seed-specific legumin promoter LeB4. GPT1 is highly expressed in vegetative sink tissues, flowers and young seeds. In the embryo, localized upregulation of GPT1 at the onset of storage coincides with the onset of starch accumulation. Embryos of transgenic plants expressing antisense GPT1 showed a significant reduction (up to 55%) in the specific transport rate of glucose-6-phosphate as determined using proteoliposomes prepared from embryos. Furthermore, amyloplasts developed later and were smaller in size, while the expression of genes encoding plastid-specific translocators and proteins involved in starch biosynthesis was decreased. Metabolite analysis and stable isotope labelling demonstrated that starch biosynthesis was also reduced, although storage protein biosynthesis increased. This metabolic shift was characterized by upregulation of genes related to nitrogen uptake and protein storage, morphological variation of the protein-storing vacuoles, and a crude protein content of mature seeds of transgenics that was up to 30% higher than in wild-type. These findings provide evidence that (1) the prevailing level of GPT1 abundance/activity is rate-limiting for the synthesis of starch in developing seeds, (2) GPT1 exerts a controlling function on assimilate partitioning into storage protein, and (3) GPT1 is essential for the differentiation of embryonic plastids and seed maturation.

  17. Shifting Attention

    ERIC Educational Resources Information Center

    Ingram, Jenni

    2014-01-01

    This article examines the shifts in attention and focus as one teacher introduces and explains an image that represents the processes involved in a numeric problem that his students have been working on. This paper takes a micro-analytic approach to examine how the focus of attention shifts through what the teacher and students do and say in the…

  18. Fluid Shifts

    NASA Technical Reports Server (NTRS)

    Stenger, M. B.; Hargens, A.; Dulchavsky, S.; Ebert, D.; Lee, S.; Laurie, S.; Garcia, K.; Sargsyan, A.; Martin, D.; Lui, J.; Macias, B.; Arbeille, P.; Danielson, R.; Chang, D.; Gunga, H.; Johnston, S.; Westby, C.; Ribeiro, L.; Ploutz-Snyder, R.; Smith, S.

    2015-01-01

    INTRODUCTION: Mechanisms responsible for the ocular structural and functional changes that characterize the visual impairment and intracranial pressure (ICP) syndrome (VIIP) are unclear, but hypothesized to be secondary to the cephalad fluid shift experienced in spaceflight. This study will relate the fluid distribution and compartmentalization associated with long-duration spaceflight with VIIP symptoms. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as the VIIP-related effects of those shifts, can be predicted preflight with acute hemodynamic manipulations, and also if lower body negative pressure (LBNP) can reverse the VIIP effects. METHODS: Physiologic variables will be examined pre-, in- and post-flight in 10 International Space Station crewmembers including: fluid compartmentalization (D2O and NaBr dilution); interstitial tissue thickness (ultrasound); vascular dimensions and dynamics (ultrasound and MRI (including cerebrospinal fluid pulsatility)); ocular measures (optical coherence tomography, intraocular pressure, ultrasound); and ICP measures (tympanic membrane displacement, otoacoustic emissions). Pre- and post-flight measures will be assessed while upright, supine and during 15 deg head-down tilt (HDT). In-flight measures will occur early and late during 6 or 12 month missions. LBNP will be evaluated as a countermeasure during HDT and during spaceflight. RESULTS: The first two crewmembers are in the preflight testing phase. Preliminary results characterize the acute fluid shifts experienced from upright, to supine and HDT postures (increased stroke volume, jugular dimensions and measures of ICP) which are reversed with 25 millimeters Hg LBNP. DISCUSSION: Initial results indicate that acute cephalad fluid shifts may be related to VIIP symptoms, but also may be reversible by LBNP. The effect of a chronic fluid shift has yet to be evaluated. Learning Objectives: Current spaceflight VIIP research is described

  19. Fluid Shifts

    NASA Technical Reports Server (NTRS)

    Stenger, M.; Hargens, A.; Dulchavsky, S.; Ebert, D.; Lee, S.; Lauriie, S.; Garcia, K.; Sargsyan, A.; Martin, D.; Ribeiro, L.; Lui, J.; Macias, B.; Arbeille, P.; Danielson, R.; Chang, D.; Johnston, S.; Ploutz-Snyder, R.; Smith, S.

    2016-01-01

    NASA is focusing on long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low-Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but more than 50% of ISS astronauts experienced more profound, chronic changes with objective structural and functional findings such as papilledema and choroidal folds. Globe flattening, optic nerve sheath dilation, and optic nerve tortuosity also are apparent. This pattern is referred to as the visual impairment and intracranial pressure (VIIP) syndrome. VIIP signs and symptoms, as well as postflight lumbar puncture data, suggest that elevated intracranial pressure (ICP) may be associated with the spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight, and to correlate these findings with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as the VIIP-related effects of those shifts, is predicted by the crewmember's preflight conditions and responses to acute hemodynamic manipulations (such as head-down tilt). Lastly, we will evaluate the patterns of fluid distribution in ISS astronauts during acute reversal of fluid shifts through application of lower body negative pressure (LBNP) interventions to characterize and explain general and individual responses. METHODS: We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the Figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, calcaneus tissue thickness (by

  20. Fluid Shifts

    NASA Technical Reports Server (NTRS)

    Stenger, Michael; Hargens, A.; Dulchavsky, S.; Ebert, D.; Lee, S.; Sargsyan, A.; Martin, D.; Lui, J.; Macias, B.; Arbeille, P.; Platts, S.

    2014-01-01

    NASA is focusing on long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but more than 30% of ISS astronauts experience more profound, chronic changes with objective structural and functional findings such as papilledema and choroidal folds. Globe flattening, optic nerve sheath dilation, and optic nerve tortuosity also are apparent. This pattern is referred to as the visual impairment and intracranial pressure (VIIP) syndrome. VIIP signs and symptoms, as well as postflight lumbar puncture data, suggest that elevated intracranial pressure (ICP) may be associated with the space flight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration space flight, and to correlate these findings with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during space flight, as well as the VIIP-related effects of those shifts, is predicted by the crewmember's pre-flight condition and responses to acute hemodynamic manipulations (such as head-down tilt). Lastly, we will evaluate the patterns of fluid distribution in ISS astronauts during acute reversal of fluid shifts through application of lower body negative pressure (LBNP) interventions to characterize and explain general and individual responses. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the Figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, calcaneus tissue thickness (by ultrasound

  1. Fluid Shifts

    NASA Technical Reports Server (NTRS)

    Stenger, M. B.; Hargens, A. R.; Dulchavsky, S. A.; Arbeille, P.; Danielson, R. W.; Ebert, D. J.; Garcia, K. M.; Johnston, S. L.; Laurie, S. S.; Lee, S. M. C.; Liu, J.; Macias, B.; Martin, D. S.; Minkoff, L.; Ploutz-Snyder, R.; Ribeiro, L. C.; Sargsyan, A.; Smith, S. M.

    2017-01-01

    Introduction. NASA's Human Research Program is focused on addressing health risks associated with long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but now more than 50 percent of ISS astronauts have experienced more profound, chronic changes with objective structural findings such as optic disc edema, globe flattening and choroidal folds. These structural and functional changes are referred to as the visual impairment and intracranial pressure (VIIP) syndrome. Development of VIIP symptoms may be related to elevated intracranial pressure (ICP) secondary to spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight and to determine if a relation exists with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as any VIIP-related effects of those shifts, are predicted by the crewmember's pre-flight status and responses to acute hemodynamic manipulations, specifically posture changes and lower body negative pressure. Methods. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, and calcaneus tissue thickness (by ultrasound); (3) vascular dimensions by ultrasound (jugular veins, cerebral and carotid arteries, vertebral arteries and veins, portal vein); (4) vascular dynamics by MRI (head/neck blood flow, cerebrospinal fluid

  2. Characterization of Temporal Semantic Shifts of Peer-to-Peer Communication in a Health-Related Online Community: Implications for Data-driven Health Promotion

    PubMed Central

    Sridharan, Vishnupriya; Cohen, Trevor; Cobb, Nathan; Myneni, Sahiti

    2016-01-01

    With online social platforms gaining popularity as venues of behavior change, it is important to understand the ways in which these platforms facilitate peer interactions. In this paper, we characterize temporal trends in user communication through mapping of theoretically-linked semantic content. We used qualitative coding and automated text analysis to assign theoretical techniques to peer interactions in an online community for smoking cessation, subsequently facilitating temporal visualization of the observed techniques. Results indicate manifestation of several behavior change techniques such as feedback and monitoring’ and ‘rewards’. Automated methods yielded reasonable results (F-measure=0.77). Temporal trends among relapsers revealed reduction in communication after a relapse event. This social withdrawal may be attributed to failure guilt after the relapse. Results indicate significant change in thematic categories such as ‘social support’, ‘natural consequences’, and ‘comparison of outcomes’ pre and post relapse. Implications for development of behavioral support technologies that promote long-term abstinence are discussed. PMID:28269957

  3. Human resources for health: task shifting to promote basic health service delivery among internally displaced people in ethnic health program service areas in eastern Burma/Myanmar

    PubMed Central

    Low, Sharon; Tun, Kyaw Thura; Mhote, Naw Pue Pue; Htoo, Saw Nay; Maung, Cynthia; Kyaw, Saw Win; Shwe Oo, Saw Eh Kalu; Pocock, Nicola Suyin

    2014-01-01

    Background Burma/Myanmar was controlled by a military regime for over 50 years. Many basic social and protection services have been neglected, specifically in the ethnic areas. Development in these areas was led by the ethnic non-state actors to ensure care and the availability of health services for the communities living in the border ethnic-controlled areas. Political changes in Burma/Myanmar have been ongoing since the end of 2010. Given the ethnic diversity of Burma/Myanmar, many challenges in ensuring health service coverage among all ethnic groups lie ahead. Methods A case study method was used to document how existing human resources for health (HRH) reach the vulnerable population in the ethnic health organizations’ (EHOs) and community-based organizations’ (CBHOs) service areas, and their related information on training and services delivered. Mixed methods were used. Survey data on HRH, service provision, and training were collected from clinic-in-charges in 110 clinics in 14 Karen/Kayin townships through a rapid-mapping exercise. We also reviewed 7 organizational and policy documents and conducted 10 interviews and discussions with clinic-in-charges. Findings Despite the lack of skilled medical professionals, the EHOs and CBHOs have been serving the population along the border through task shifting to less specialized health workers. Clinics and mobile teams work in partnership, focusing on primary care with some aspects of secondary care. The rapid-mapping exercise showed that the aggregate HRH density in Karen/Kayin state is 2.8 per 1,000 population. Every mobile team has 1.8 health workers per 1,000 population, whereas each clinic has between 2.5 and 3.9 health workers per 1,000 population. By reorganizing and training the workforce with a rigorous and up-to-date curriculum, EHOs and CBHOs present a viable solution for improving health service coverage to the underserved population. Conclusion Despite the chronic conflict in Burma/Myanmar, this

  4. Shifting sugars and shifting paradigms.

    PubMed

    Siegal, Mark L

    2015-02-01

    No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available and glucose, a better sugar, is not. However, recent studies, including three PLOS Biology papers examining sugar utilization in the budding yeast Saccharomyces cerevisiae, show that considerable heterogeneity in response to complex environments exists within and between populations. These results join similar recent results in other organisms that suggest that microbial populations anticipate predictable environmental changes and hedge their bets against unpredictable ones. The classical view therefore represents but one special case in a range of evolutionary adaptations to environmental changes that all organisms face.

  5. Psychopathology of Shift Work.

    ERIC Educational Resources Information Center

    Akinnawo, Ebenezer Olutope

    1989-01-01

    Examined incidence and nature of general psychopathology among Nigerian shift workers (N=320). Found shift workers more significantly psychopathological than non-shift workers (p<0.001). Prominent disorders among shift workers were intellectual, sleep, mood, and general somatic disorders. No significant difference could be attributed to gender…

  6. Gear shift control mechanism

    SciTech Connect

    Janson, D.A.

    1987-03-10

    A gear shift control mechanism is described comprising: multiple shift rods directed substantially parallel to one another, each rod carrying a shift fork for axial movement; a shift lever supported for pivotal movement about a first axis directed parallel to the axes of the shift rods and for pivotal movement about a second axis directed substantially perpendicular to the axes of the shift rods. The lever is moveable about the first axis and the second axis into engagement with a selected shift fork; interlock means located on each lateral side of the shift lever and mounted for pivotal movement about the first axis for blocking engagement with the shift forks; detent means for holding the shift lever in multiple predetermined angular positions about the second axis; and spring means located on a lateral side of the shift lever and mounted for pivotal movement about the first axis into interference contact with the shift forks for producing a force tending to resiliently bias the shift lever out of engagement with the selected shift fork.

  7. Making Shifts toward Proficiency

    ERIC Educational Resources Information Center

    McGatha, Maggie B.; Bay-Williams, Jennifer M.

    2013-01-01

    The Leading for Mathematical Proficiency (LMP) Framework (Bay-Williams et al.) has three components: (1) The Standards for Mathematical Practice; (2) Shifts in classroom practice; and (3) Teaching skills. This article briefly describes each component of the LMP framework and then focuses more in depth on the second component, the shifts in…

  8. Shifting scintillator neutron detector

    DOEpatents

    Clonts, Lloyd G; Cooper, Ronald G; Crow, Jr., Morris Lowell; Hannah, Bruce W; Hodges, Jason P; Richards, John D; Riedel, Richard A

    2014-03-04

    Provided are sensors and methods for detecting thermal neutrons. Provided is an apparatus having a scintillator for absorbing a neutron, the scintillator having a back side for discharging a scintillation light of a first wavelength in response to the absorbed neutron, an array of wavelength-shifting fibers proximate to the back side of the scintillator for shifting the scintillation light of the first wavelength to light of a second wavelength, the wavelength-shifting fibers being disposed in a two-dimensional pattern and defining a plurality of scattering plane pixels where the wavelength-shifting fibers overlap, a plurality of photomultiplier tubes, in coded optical communication with the wavelength-shifting fibers, for converting the light of the second wavelength to an electronic signal, and a processor for processing the electronic signal to identify one of the plurality of scattering plane pixels as indicative of a position within the scintillator where the neutron was absorbed.

  9. Instantaneous phase shifting deflectometry.

    PubMed

    Trumper, Isaac; Choi, Heejoo; Kim, Dae Wook

    2016-11-28

    An instantaneous phase shifting deflectometry measurement method is presented and implemented by measuring a time varying deformable mirror with an iPhone ® 6. The instantaneous method is based on multiplexing phase shifted fringe patterns with color, and decomposing them in x and y using Fourier techniques. Along with experimental data showing the capabilities of the instantaneous deflectometry system, a quantitative comparison with the Fourier transform profilometry method, which is a distinct phase measuring method from the phase shifting approach, is presented. Sources of error, nonlinear color-multiplexing induced error correction, and hardware limitations are discussed.

  10. Improved feedback shift register

    NASA Technical Reports Server (NTRS)

    Perlman, M.

    1972-01-01

    Design of feedback shift register with three tap feedback decoding scheme is described. Application for obtaining sequence synchronization patterns is examined. Operation of the circuitry is described and drawings of the systems are included.

  11. Shape-Shifting Plastic

    SciTech Connect

    2015-05-20

    A new plastic developed by ORNL and Washington State University transforms from its original shape through a series of temporary shapes and returns to its initial form. The shape-shifting process is controlled through changes in temperature

  12. Our World: Fluid Shift

    NASA Video Gallery

    Learn about the circulatory system and how gravity aids blood flow in our bodies here on Earth. Find out how NASA flight surgeons help the astronauts deal with the fluid shift that happens during s...

  13. Shift Verification and Validation

    SciTech Connect

    Pandya, Tara M.; Evans, Thomas M.; Davidson, Gregory G; Johnson, Seth R.; Godfrey, Andrew T.

    2016-09-07

    This documentation outlines the verification and validation of Shift for the Consortium for Advanced Simulation of Light Water Reactors (CASL). Five main types of problems were used for validation: small criticality benchmark problems; full-core reactor benchmarks for light water reactors; fixed-source coupled neutron-photon dosimetry benchmarks; depletion/burnup benchmarks; and full-core reactor performance benchmarks. We compared Shift results to measured data and other simulated Monte Carlo radiation transport code results, and found very good agreement in a variety of comparison measures. These include prediction of critical eigenvalue, radial and axial pin power distributions, rod worth, leakage spectra, and nuclide inventories over a burn cycle. Based on this validation of Shift, we are confident in Shift to provide reference results for CASL benchmarking.

  14. Straddling a paradigm shift

    SciTech Connect

    Landgren, D.

    1995-05-01

    Paul Meagher made a big mistake when he asked me about my speech. I asked him what I should talk about. He reiterated the title of the conference {open_quotes}Forecasting and DSM: Organizing for Success,{close_quotes} and said that whatever issues I wanted to cover were fine with him. As a result I will cover those areas I`ve been thinking about recently. It is hard for me to extract either Forecasting or Demand-Side Management out from the broader issues unwinding in the industry today. I`ve been around long enough to be involved in two major shifts in the industry. I call these paradigm shifts because as a planner I tend to build models in my mind to represent business or regulatory structure. Since a paradigm is defined as a clear model of something, I tend to talk about structural shifts in the industry as paradigm shifts. The first paradigm shift was brought about by the rapid escalation of energy prices in the 1970s. The second paradigm shift, brought about in part because of the first and because of growing concerns about the environment, ushered in the era of utility conservation and load management programs (components of a broader DSM concept - unfortunately today many people limit DSM to only these two pieces). The third paradigm shift is just starting, driven by partial deregulation and the subsequent increase in competition. My talk today will focus on issues related to the second paradigm, particularly in terms of utility planners getting more organized to deal with the synergies in the fields of forecasting, demand-side planning, and evaluation. I will also reflect on two new issues within the existing paradigm that influence these functional areas, namely beneficial electrification and integration of DSM into T&D planning. Finally I will talk about what I see coming as we go through another paradigm shift, particularly as it impacts forecasting and DSM.

  15. Molecular Electronic Shift Registers

    NASA Technical Reports Server (NTRS)

    Beratan, David N.; Onuchic, Jose N.

    1990-01-01

    Molecular-scale shift registers eventually constructed as parts of high-density integrated memory circuits. In principle, variety of organic molecules makes possible large number of different configurations and modes of operation for such shift-register devices. Several classes of devices and implementations in some specific types of molecules proposed. All based on transfer of electrons or holes along chains of repeating molecular units.

  16. Language Shift and Language Accommodation across Family Generations in Taiwan

    ERIC Educational Resources Information Center

    Sandel, Todd L.; Chao, Wen-Yu; Liang, Chung-Hui

    2006-01-01

    This study explored language shift and accommodation among bilingual Mandarin and Tai-gi (also called Hokkien, Holo, Tai-gu, Taiwan Min, Taiwanese) families in Taiwan. From the 1940s until the 1980s the Chinese Nationalist Party (KMT) on Taiwan promoted Mandarin Chinese. Recent years have witnessed a shift in policy: since 2001 elementary schools…

  17. High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells.

    PubMed

    Kato, Sosuke; Tsukamoto, Tetsuya; Mizoshita, Tsutomu; Tanaka, Harunari; Kumagai, Toshiko; Ota, Hiroyoshi; Katsuyama, Tsutomu; Asaka, Masahiro; Tatematsu, Masae

    2006-10-01

    Intake of salt and salty food is known as a risk factor for gastric carcinogenesis. To examine the dose-dependence and the mechanisms underlying enhancing effects, Mongolian gerbils were treated with N-methyl-N-nitrosourea (MNU), Helicobacter pylori and food containing various concentrations of salt, and were sacrificed after 50 weeks. Among gerbils treated with MNU and H. pylori, the incidences of glandular stomach cancers were 15% in the normal diet group and 33%, 36% and 63% in the 2.5%, 5% and 10% NaCl diet groups, showing dose-dependent increase (p < 0.01). Intermittent intragastric injection of saturated NaCl solution, in contrast, did not promote gastric carcinogenesis. In gerbils infected with H. pylori, a high salt diet was associated with elevation of anti-H. pylori antibody titers, serum gastrin levels and inflammatory cell infiltration in a dose-dependent fashion. Ten percent NaCl diet upregulated the amount of surface mucous cell mucin (p < 0.05), suitable for H. pylori colonization, despite no increment of MUC5AC mRNA, while H. pylori infection itself had an opposing effect, stimulating transcription of MUC6 and increasing the amount of gland mucous cell mucin (GMCM). High salt diet, in turn, decreased the amount of GMCM, which acts against H. pylori infection. In conclusion, the present study demonstrated dose-dependent enhancing effects of salt in gastric chemical carcinogenesis in H. pylori-infected Mongolian gerbils associated with alteration of the mucous microenvironment. Reduction of salt intake could thus be one of the most important chemopreventive methods for human gastric carcinogenesis.

  18. Trophic shift, not collapse

    USGS Publications Warehouse

    Madenjian, Charles P.; Rutherford, Edward S.; Stow, Craig A.; Roseman, Edward F.; He, Ji X.

    2013-01-01

    scientists who are closely monitoring Lake Huron’s food web, we believe that the ongoing changes are more accurately characterized as a trophic shift in which benthic pathways have become more prominent. While decreases in abundance have occurred for some species, others are experiencing improved reproduction resulting in the restoration of several important native species.

  19. Eluding catastrophic shifts.

    PubMed

    Villa Martín, Paula; Bonachela, Juan A; Levin, Simon A; Muñoz, Miguel A

    2015-04-14

    Transitions between regimes with radically different properties are ubiquitous in nature. Such transitions can occur either smoothly or in an abrupt and catastrophic fashion. Important examples of the latter can be found in ecology, climate sciences, and economics, to name a few, where regime shifts have catastrophic consequences that are mostly irreversible (e.g., desertification, coral reef collapses, and market crashes). Predicting and preventing these abrupt transitions remains a challenging and important task. Usually, simple deterministic equations are used to model and rationalize these complex situations. However, stochastic effects might have a profound effect. Here we use 1D and 2D spatially explicit models to show that intrinsic (demographic) stochasticity can alter deterministic predictions dramatically, especially in the presence of other realistic features such as limited mobility or spatial heterogeneity. In particular, these ingredients can alter the possibility of catastrophic shifts by giving rise to much smoother and easily reversible continuous ones. The ideas presented here can help further understand catastrophic shifts and contribute to the discussion about the possibility of preventing such shifts to minimize their disruptive ecological, economic, and societal consequences.

  20. Eluding catastrophic shifts

    PubMed Central

    Villa Martín, Paula; Bonachela, Juan A.; Levin, Simon A.; Muñoz, Miguel A.

    2015-01-01

    Transitions between regimes with radically different properties are ubiquitous in nature. Such transitions can occur either smoothly or in an abrupt and catastrophic fashion. Important examples of the latter can be found in ecology, climate sciences, and economics, to name a few, where regime shifts have catastrophic consequences that are mostly irreversible (e.g., desertification, coral reef collapses, and market crashes). Predicting and preventing these abrupt transitions remains a challenging and important task. Usually, simple deterministic equations are used to model and rationalize these complex situations. However, stochastic effects might have a profound effect. Here we use 1D and 2D spatially explicit models to show that intrinsic (demographic) stochasticity can alter deterministic predictions dramatically, especially in the presence of other realistic features such as limited mobility or spatial heterogeneity. In particular, these ingredients can alter the possibility of catastrophic shifts by giving rise to much smoother and easily reversible continuous ones. The ideas presented here can help further understand catastrophic shifts and contribute to the discussion about the possibility of preventing such shifts to minimize their disruptive ecological, economic, and societal consequences. PMID:25825772

  1. Understanding NMR Chemical Shifts

    NASA Astrophysics Data System (ADS)

    Jameson, Cynthia J.

    1996-10-01

    The NMR chemical shift serves as a paradigm for molecular electronic properties. We consider the factors that determine the general magnitudes of the shifts, the state of the art in theoretical calculations, the nature of the shielding tensor, and the multidimensional shielding surface that describes the variation of the shielding with nuclear positions. We also examine the nature of the intermolecular shielding surface as a general example of a supermolecule property surface. The observed chemical shift in the zero-pressure limit is determined not only by the value of the shielding at the equilibrium geometry, but the dynamic average over the multidimensional shielding surface during rotation and vibration of the molecule. In the gas, solution, or adsorbed phase it is an average of the intermolecular shielding surface over all the configurations of the molecule with its neighbors. The temperature dependence of the chemical shift in the isolated molecule, the changes upon isotopic substitution, the changes with environment, are well characterized experimentally so that quantum mechanical descriptions of electronic structure and theories related to dynamics averaging of any electronic property can be subjected to stringent test.

  2. New shifted hybrid inflation

    NASA Astrophysics Data System (ADS)

    Jeannerot, Rachel; Khalil, Shaaban; Lazarides, George

    2002-07-01

    A new shifted hybrid inflationary scenario is introduced which, in contrast to the older one, relies only on renormalizable superpotential terms. This scenario is automatically realized in a concrete extension of the `minimal' supersymmetric Pati-Salam model which naturally leads to a moderate violation of Yukawa unification so that, for μ>0, the predicted b-quark mass is acceptable even with universal boundary conditions. It is shown that this extended model possesses a classically flat `shifted' trajectory which acquires a slope via one-loop radiative corrections and can be used as inflationary path. The constraints from the cosmic background explorer can be met with natural values of the relevant parameters. Also, there is no disastrous production of magnetic monopoles after inflation since the Pati-Salam gauge group is already broken on the `shifted' path. The relevant part of inflation takes place at values of the inflaton field which are not much smaller than the `reduced' Planck scale and, thus, supergravity corrections could easily invalidate inflation. It is, however, shown that inflation can be kept intact provided that an extra gauge singlet with a superheavy vacuum expectation value, which originates from D-terms, is introduced and a specific form of the Kähler potential is used. Moreover, it is found that, although the supergravity corrections are sizable, the constraints from the cosmic background explorer can again be met by readjusting the values of the parameters which were obtained with global supersymmetry.

  3. Transmission shift control assembly

    SciTech Connect

    Dzioba, D.L.

    1989-04-18

    This patent describes a transmission shift control assembly mounted on a steering column having a longitudinal axis comprising: bracket means secured to the steering column; transmission shift cable means having a portion secured to the bracket means and a portion linearly movable relative to the secured portion; mounting means on the bracket cable drive arm means having an axis and being rotatably mounted on the rotary axis on the mounting means oblique to the longitudinal axis and including a cable connecting portion secured to the movable portion of the cable means and lever mounting means adjacent the mounting means; operator control means including lever means, pin means for pivotally mounting the lever means on the lever mounting means on an axis substantially perpendicular to the rotary axis and positioning arm means formed on the lever means and extending from the pin means; and detent gate means disposed on the bracket means in position to abut the positioning arm means for limiting the extent of pivotal movement of the lever means.

  4. Shift Work: Improving Daytime Sleep

    MedlinePlus

    Healthy Lifestyle Adult health I just started working the night shift, and I'm having trouble sleeping during ... as long as you work the shift. Make healthy lifestyle choices. Eat a healthy diet and include physical ...

  5. Phase shifting diffraction interferometer

    DOEpatents

    Sommargren, G.E.

    1996-08-29

    An interferometer which has the capability of measuring optical elements and systems with an accuracy of {lambda}/1000 where {lambda} is the wavelength of visible light. Whereas current interferometers employ a reference surface, which inherently limits the accuracy of the measurement to about {lambda}/50, this interferometer uses an essentially perfect spherical reference wavefront generated by the fundamental process of diffraction. This interferometer is adjustable to give unity fringe visibility, which maximizes the signal-to-noise, and has the means to introduce a controlled prescribed relative phase shift between the reference wavefront and the wavefront from the optics under test, which permits analysis of the interference fringe pattern using standard phase extraction algorithms. 8 figs.

  6. Phase shifting interferometer

    DOEpatents

    Sommargren, Gary E.

    1999-01-01

    An interferometer which has the capability of measuring optical elements and systems with an accuracy of .lambda./1000 where .lambda. is the wavelength of visible light. Whereas current interferometers employ a reference surface, which inherently limits the accuracy of the measurement to about .lambda./50, this interferometer uses an essentially perfect spherical reference wavefront generated by the fundamental process of diffraction. Whereas current interferometers illuminate the optic to be tested with an aberrated wavefront which also limits the accuracy of the measurement, this interferometer uses an essentially perfect spherical measurement wavefront generated by the fundamental process of diffraction. This interferometer is adjustable to give unity fringe visibility, which maximizes the signal-to-noise, and has the means to introduce a controlled prescribed relative phase shift between the reference wavefront and the wavefront from the optics under test, which permits analysis of the interference fringe pattern using standard phase extraction algorithms.

  7. Phase shifting diffraction interferometer

    DOEpatents

    Sommargren, Gary E.

    1996-01-01

    An interferometer which has the capability of measuring optical elements and systems with an accuracy of .lambda./1000 where .lambda. is the wavelength of visible light. Whereas current interferometers employ a reference surface, which inherently limits the accuracy of the measurement to about .lambda./50, this interferometer uses an essentially perfect spherical reference wavefront generated by the fundamental process of diffraction. This interferometer is adjustable to give unity fringe visibility, which maximizes the signal-to-noise, and has the means to introduce a controlled prescribed relative phase shift between the reference wavefront and the wavefront from the optics under test, which permits analysis of the interference fringe pattern using standard phase extraction algorithms.

  8. Phase shifting interferometer

    DOEpatents

    Sommargren, G.E.

    1999-08-03

    An interferometer is disclosed which has the capability of measuring optical elements and systems with an accuracy of {lambda}/1000 where {lambda} is the wavelength of visible light. Whereas current interferometers employ a reference surface, which inherently limits the accuracy of the measurement to about {lambda}/50, this interferometer uses an essentially perfect spherical reference wavefront generated by the fundamental process of diffraction. Whereas current interferometers illuminate the optic to be tested with an aberrated wavefront which also limits the accuracy of the measurement, this interferometer uses an essentially perfect spherical measurement wavefront generated by the fundamental process of diffraction. This interferometer is adjustable to give unity fringe visibility, which maximizes the signal-to-noise, and has the means to introduce a controlled prescribed relative phase shift between the reference wavefront and the wavefront from the optics under test, which permits analysis of the interference fringe pattern using standard phase extraction algorithms. 11 figs.

  9. Hydraulically actuated well shifting tool

    SciTech Connect

    Roth, B.A.

    1992-10-20

    This patent describes a hydraulically actuated shifting tool for actuating a sliding member in a well tool. It comprises: a housing having a hydraulic fluid bore therein; shifting dog means positioned on the housing for movement away and toward the housing; locking dog means positioned on the housing for movement away and toward the body; shifting dog hydraulic actuating means in fluid communication with the bore for causing engagement of the shifting dogs with the sliding member; locking dog hydraulic actuating means in communication with the bore for causing engagement of the locking dogs with the locking means; and hydraulic shifting means in communication with the bore for causing relative movement between the shifting dog means and the locking dog means for shifting the sliding sleeve.

  10. Antiretroviral therapy: Shifting sands

    PubMed Central

    Sashindran, V.K.; Chauhan, Rajeev

    2016-01-01

    HIV/AIDS has been an extremely difficult pandemic to control. However, with the advent of antiretroviral therapy (ART), HIV has now been transformed into a chronic illness in patients who have continued treatment access and excellent long-term adherence. Existing indications for ART initiation in asymptomatic patients were based on CD4 levels; however, recent evidence has broken the shackles of CD4 levels. Early initiation of ART in HIV patients irrespective of CD4 counts can have profound positive impact on morbidity and mortality. Early initiation of ART has been found not only beneficial for patients but also to community as it reduces the risk of transmission. There have been few financial concerns about providing ART to all HIV-positive people but various studies have proven that early initiation of ART not only proves to be cost-effective but also contributes to economic and social growth of community. A novel multidisciplinary approach with early initiation and availability of ART at its heart can turn the tide in our favor in future. Effective preexposure prophylaxis and postexposure prophylaxis can also lower transmission risk of HIV in community. New understanding of HIV pathogenesis is opening new vistas to cure and prevention. Various promising candidate vaccines and drugs are undergoing aggressive clinical trials, raising optimism for an ever-elusive cure for HIV. This review describes various facets of tectonic shift in management of HIV. PMID:26900224

  11. Phase-shift coherence holography.

    PubMed

    Naik, Dinesh N; Ezawa, Takahiro; Miyamoto, Yoko; Takeda, Mitsuo

    2010-05-15

    We propose and experimentally demonstrate a new reconstruction scheme for coherence holography using computer-generated phase-shift coherence holograms. A 3D object encoded into the spatial coherence function is reconstructed directly from a set of incoherently illuminated computer-generated holograms with numerically introduced phase shifts. Although a rotating ground glass is used to introduce spatially incoherent illumination, the phase-shifting portion of the system is simple and free from mechanically moving components.

  12. Zero-shifted accelerometer outputs

    NASA Astrophysics Data System (ADS)

    Galef, Arnold

    1986-08-01

    It is claimed that the commonly appearing zero-shift in pyroshock data is usually a symptom of a malfunctioning measurement system, so that the data can not be repaired (by high-pass filtering or equivalent) unless tests can be devised that permit the demonstration that the system is operating in a linear mode in all respects other than the shift. The likely cause of the zero-shift and its prevention are discussed.

  13. Quantized beam shifts in graphene

    SciTech Connect

    de Melo Kort-Kamp, Wilton Junior; Sinitsyn, Nikolai; Dalvit, Diego Alejandro Roberto

    2015-10-08

    We predict the existence of quantized Imbert-Fedorov, Goos-Hanchen, and photonic spin Hall shifts for light beams impinging on a graphene-on-substrate system in an external magnetic field. In the quantum Hall regime the Imbert-Fedorov and photonic spin Hall shifts are quantized in integer multiples of the fine structure constant α, while the Goos-Hanchen ones in multiples of α2. We investigate the influence on these shifts of magnetic field, temperature, and material dispersion and dissipation. An experimental demonstration of quantized beam shifts could be achieved at terahertz frequencies for moderate values of the magnetic field.

  14. Thermochromic shifts in supercritical fluids

    SciTech Connect

    Yonker, C.R.; Smith, R.D. )

    1989-02-23

    Thermochromic shifts of organic solute molecules in supercritical CO{sub 2} under conditions of both constant pressure and density are compared to previous studies of solvatochromic shifts at isothermal conditions. Similar solvatochromic and thermochromic shifts are seen as a function of density for supercritical CO{sub 2}. At constant density a small thermochromic shift ({approx}400 cm{sup {minus}1}) for supercritical CO{sub 2} was seen for both 2-nitroanisole and 4-ethylnitrobenzene. The excited-state dipole moments for 2-nitroanisole, as calculated from the thermochromic and solvatochromic data, were in agreement.

  15. Shifts in fisheries management: adapting to regime shifts

    PubMed Central

    King, Jacquelynne R.; McFarlane, Gordon A.; Punt, André E.

    2015-01-01

    For many years, fisheries management was based on optimizing yield and maintaining a target biomass, with little regard given to low-frequency environmental forcing. However, this policy was often unsuccessful. In the last two to three decades, fisheries science and management have undergone a shift towards balancing sustainable yield with conservation, with the goal of including ecosystem considerations in decision-making frameworks. Scientific understanding of low-frequency climate–ocean variability, which is manifested as ecosystem regime shifts and states, has led to attempts to incorporate these shifts and states into fisheries assessment and management. To date, operationalizing these attempts to provide tactical advice has met with limited success. We review efforts to incorporate regime shifts and states into the assessment and management of fisheries resources, propose directions for future investigation and outline a potential framework to include regime shifts and changes in ecosystem states into fisheries management.

  16. Health Promotion

    DTIC Science & Technology

    1986-03-11

    Department of Defense DIRECTIVEAD-A269 638 , , AD-A29 638March 11, 1986 IIIIii!IN 111111111,11 Ii1111,111111[NUMBER 1010.10 SUBJECT: Health Promotion ...34 March 13, 1985 INC A. URPOSE SThis Directive establishes a health promotion policy within the Department of Defense to improve and maintain military...civilian employees. C. DEFINITIONS 1. Health Promotion . Any combination of health education and related organizational, social, economic or health care

  17. Zoning should promote public health.

    PubMed

    Hirschhorn, Joel S

    2004-01-01

    Legally, governments use their police powers to protect public health, safety, and welfare through zoning. This paper presents a case for revisiting zoning on the basis of increasing evidence that certain types of community design promote public health, as opposed to the dominant pattern of sprawl development, which does not. Zoning, and the land use planning linked to it, that prohibits or disfavors health-promoting community designs contradicts the inherent public policy goal on which it is based. If there is a paradigm shift underway, from traditional sprawl to health-promoting community designs, then health professionals and others should understand why zoning must be reassessed.

  18. Metabolic impact of shift work.

    PubMed

    Zimberg, Ioná Zalcman; Fernandes Junior, Silvio A; Crispim, Cibele Aparecida; Tufik, Sergio; de Mello, Marco Tulio

    2012-01-01

    In developing countries, shift work represents a considerable contingent workforce. Recently, studies have shown that overweight and obesity are more prevalent in shift workers than day workers. In addition, shift work has been associated with a higher propensity for the development of many metabolic disorders, such as insulin resistance, diabetes, dislipidemias and metabolic syndrome. Recent data have pointed that decrease of the sleep time, desynchronization of circadian rhythm and alteration of environmental aspects are the main factors related to such problems. Shortened or disturbed sleep is among the most common health-related effects of shift work. The plausible physiological and biological mechanisms are related to the activation of the autonomic nervous system, inflammation, changes in lipid and glucose metabolism, and related changes in the risk for atherosclerosis, metabolic syndrome, and type II diabetes. The present review will discuss the impact of shift work on obesity and metabolic disorders and how disruption of sleep and circadian misalignment may contribute to these metabolic dysfunctions.

  19. Orchestrating energy for shifting busyness to strategic work.

    PubMed

    Shirey, Maria R; Hites, Lisle

    2015-03-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. In this article, the authors discuss the elements of busy work and offers strategies for shifting to focused, strategic work. A useful energy preservation framework is introduced to promote vitality that drives engagement, productivity, and innovation.

  20. Health Effects of Shift Work

    PubMed Central

    LaDou, Joseph

    1982-01-01

    More than 13.5 million American workers, close to 20 percent of the work force, are assigned to evening or night shifts. In some industries such as automobile, petrochemical and textile manufacturing the proportion of shift workers is greater than 50 percent. As the popularity of shift work and other “alternative work schedules” grows, concern is increasing over the disturbance created in the lives of workers and their families by these economically and socially useful innovations. Twenty percent of workers are unable to tolerate shift work. Daily physiologic variations termed circadian rhythms are interactive and require a high degree of phase relationship to produce subjective feelings of wellbeing. Disturbance of these activities, circadian desynchronization, whether from passage over time zones or from shift rotation, results in health effects such as disturbance of the quantity and quality of sleep, disturbance of gastrointestinal and other organ system activities, and aggravation of diseases such as diabetes mellitus, epilepsy and thyrotoxicosis. Worker selection can reduce the number of health problems resulting from shift work. The periodic examination of shift workers is recommended. PMID:6962577

  1. Climate and vegetational regime shifts in the late Paleozoic ice age earth.

    PubMed

    DiMichele, W A; Montañez, I P; Poulsen, C J; Tabor, N J

    2009-03-01

    The late Paleozoic earth experienced alternation between glacial and non-glacial climates at multiple temporal scales, accompanied by atmospheric CO2 fluctuations and global warming intervals, often attended by significant vegetational changes in equatorial latitudes of Pangaea. We assess the nature of climate-vegetation interaction during two time intervals: middle-late Pennsylvanian transition and Pennsylvanian-Permian transition, each marked by tropical warming and drying. In case study 1, there is a catastrophic intra-biomic reorganization of dominance and diversity in wetland, evergreen vegetation growing under humid climates. This represents a threshold-type change, possibly a regime shift to an alternative stable state. Case study 2 is an inter-biome dominance change in western and central Pangaea from humid wetland and seasonally dry to semi-arid vegetation. Shifts between these vegetation types had been occurring in Euramerican portions of the equatorial region throughout the late middle and late Pennsylvanian, the drier vegetation reaching persistent dominance by Early Permian. The oscillatory transition between humid and seasonally dry vegetation appears to demonstrate a threshold-like behavior but probably not repeated transitions between alternative stable states. Rather, changes in dominance in lowland equatorial regions were driven by long-term, repetitive climatic oscillations, occurring with increasing intensity, within overall shift to seasonal dryness through time. In neither case study are there clear biotic or abiotic warning signs of looming changes in vegetational composition or geographic distribution, nor is it clear that there are specific, absolute values or rates of environmental change in temperature, rainfall distribution and amount, or atmospheric composition, approach to which might indicate proximity to a terrestrial biotic-change threshold.

  2. Refining the shifted topological vertex

    SciTech Connect

    Drissi, L. B.; Jehjouh, H.; Saidi, E. H.

    2009-01-15

    We study aspects of the refining and shifting properties of the 3d MacMahon function C{sub 3}(q) used in topological string theory and BKP hierarchy. We derive the explicit expressions of the shifted topological vertex S{sub {lambda}}{sub {mu}}{sub {nu}}(q) and its refined version T{sub {lambda}}{sub {mu}}{sub {nu}}(q,t). These vertices complete results in literature.

  3. Goos-Hänchen shift.

    PubMed

    Snyder, A W; Love, J D

    1976-01-01

    An extremely simple derivation of the Goos-Hänchen shift is presented for total internal reflection at a plane interface between two semiinfinite dielectric media, as well as for optical waveguides of plane arid circular cross section. The derivation is based on energy considerations, requires knowledge of Fresnel's equation only, and shows explicitly that the shift is due to the flow of energy across the dielectric boundary.

  4. Health Promotion

    PubMed Central

    Wilson, Ron

    1992-01-01

    How physicians address issues of disease prevention and health promotion is discussed and current standards of screening for disease and counseling practices are reviewed. Collaboration among all health professionals is necessary if preventive medicine is to be effective. PMID:21221259

  5. Blue shifts vs red shifts in sigma-hole bonding.

    PubMed

    Murray, Jane S; Concha, Monica C; Lane, Pat; Hobza, Pavel; Politzer, Peter

    2008-08-01

    Sigma-hole bonding is a noncovalent interaction between a region of positive electrostatic potential on the outer surface of a Group V, VI, or VII covalently-bonded atom (a sigma-hole) and a region of negative potential on another molecule, e.g., a lone pair of a Lewis base. We have investigated computationally the occurrence of increased vibration frequencies (blue shifts) and bond shortening vs decreased frequencies (red shifts) and bond lengthening for the covalent bonds to the atoms having the sigma-holes (the sigma-hole donors). Both are possible, depending upon the properties of the donor and the acceptor. Our results are consistent with models that were developed earlier by Hermansson and by Qian and Krimm in relation to blue vs red shifting in hydrogen bond formation. These models invoke the derivatives of the permanent and the induced dipole moments of the donor molecule.

  6. Integrated reformer and shift reactor

    DOEpatents

    Bentley, Jeffrey M.; Clawson, Lawrence G.; Mitchell, William L.; Dorson, Matthew H.

    2006-06-27

    A hydrocarbon fuel reformer for producing diatomic hydrogen gas is disclosed. The reformer includes a first reaction vessel, a shift reactor vessel annularly disposed about the first reaction vessel, including a first shift reactor zone, and a first helical tube disposed within the first shift reactor zone having an inlet end communicating with a water supply source. The water supply source is preferably adapted to supply liquid-phase water to the first helical tube at flow conditions sufficient to ensure discharge of liquid-phase and steam-phase water from an outlet end of the first helical tube. The reformer may further include a first catalyst bed disposed in the first shift reactor zone, having a low-temperature shift catalyst in contact with the first helical tube. The catalyst bed includes a plurality of coil sections disposed in coaxial relation to other coil sections and to the central longitudinal axis of the reformer, each coil section extending between the first and second ends, and each coil section being in direct fluid communication with at least one other coil section.

  7. Random registry shifts in quasi-one-dimensional adsorbate systems

    NASA Astrophysics Data System (ADS)

    Schäfer, J.; Erwin, S. C.; Hansmann, M.; Song, Z.; Rotenberg, E.; Kevan, S. D.; Hellberg, C. S.; Horn, K.

    2003-02-01

    The apparent contradiction of one-dimensional adsorbate chains on Si(111) having a 3×2 unit cell and yet a 3×1 diffraction pattern is resolved for the example of Ba/Si(111)-(3×2). Random registry shifts between adsorbate chains are observed in tunneling microscopy, with very short interchain correlation lengths. Fourier analysis provides a natural explanation for a pseudo-(3×1) diffraction pattern. Within density-functional theory such registry shifts can occur with essentially negligible energy cost, leading to entropy-driven, virtually perfect disorder. Substrate states of high symmetry and one-dimensional character are inferred to promote this phenomenon.

  8. Random registry shifts in quasi-one-dimensional adsorbate systems

    SciTech Connect

    Schafer, J.; Erwin, S.C.; Hansmann, M.; Song, Z.; Rotenberg, E.; Kevan, S.D.; Hellberg, C.S.; Horn, K.

    2003-02-18

    The apparent contradiction of one-dimensional adsorbate chains on Si(111) having a 3x2 unit cell and yet a 3x1 diffraction pattern is resolved for the example of Ba/Si(111)-(3x2). Random registry shifts between adsorbate chains are observed in tunneling microscopy, with very short interchain correlation lengths. Fourier analysis provides a natural explanation for a pseudo-(3x1) diffraction pattern. Within density-functional theory such registry shifts can occur with essentially negligible energy cost, leading to entropy-driven, virtually perfect disorder. Substrate states of high symmetry and one-dimensional character are inferred to promote this phenomenon.

  9. Health Promotion

    PubMed Central

    Karmali-Rawji, Shameela; Kassim-Lakha, Shaheen; Taylor, Karmel

    1992-01-01

    Perceived lack or loss of control, stress, a rapidly again population and rising costs of health care necessitate effective health promotion and disease prevention in the elderly. In a collaborative health promotion effort, the private sector, public sector, and community partners have joined to increase the South Asian elders' sense of control over the decisions and circumstances that affect their everyday lives. The project was designed to help elders come to terms with the fragmentation of their extended families, cultural alienation, decreased autonomy, need for information, and greater risk of cardiovascular disease. Imagesp622-a

  10. Paradigm Shifts in Ophthalmic Diagnostics*

    PubMed Central

    Sebag, J.; Sadun, Alfredo A.; Pierce, Eric A.

    2016-01-01

    Purpose Future advances in ophthalmology will see a paradigm shift in diagnostics from a focus on dysfunction and disease to better measures of psychophysical function and health. Practical methods to define genotypes will be increasingly important and non-invasive nanotechnologies are needed to detect molecular changes that predate histopathology. Methods This is not a review nor meant to be comprehensive. Specific topics have been selected to illustrate the principles of important paradigm shifts that will influence the future of ophthalmic diagnostics. It is our impression that future evaluation of vision will go beyond visual acuity to assess ocular health in terms of psychophysical function. The definition of disease will incorporate genotype into what has historically been a phenotype-centric discipline. Non-invasive nanotechnologies will enable a paradigm shift from disease detection on a cellular level to a sub-cellular molecular level. Results Vision can be evaluated beyond visual acuity by measuring contrast sensitivity, color vision, and macular function, as these provide better insights into the impact of aging and disease. Distortions can be quantified and the psychophysical basis of vision can be better evaluated than in the past by designing tests that assess particular macular cell function(s). Advances in our understanding of the genetic basis of eye diseases will enable better characterization of ocular health and disease. Non-invasive nanotechnologies can assess molecular changes in the lens, vitreous, and macula that predate visible pathology. Oxygen metabolism and circulatory physiology are measurable indices of ocular health that can detect variations of physiology and early disease. Conclusions This overview of paradigm shifts in ophthalmology suggests that the future will see significant improvements in ophthalmic diagnostics. The selected topics illustrate the principles of these paradigm shifts and should serve as a guide to further

  11. Wavelength-shifted Cherenkov radiators

    NASA Technical Reports Server (NTRS)

    Krider, E. P.; Jacobson, V. L.; Pifer, A. E.; Polakos, P. A.; Kurz, R. J.

    1976-01-01

    The scintillation and Cherenkov responses of plastic Cherenkov radiators containing different wavelength-shifting fluors in varying concentrations have been studied in beams of low energy protons and pions. For cosmic ray applications, where large Cherenkov to scintillation ratios are desired, the optimum fluor concentrations are 0.000025 by weight or less.

  12. Leadership Shifts in Changing Field

    ERIC Educational Resources Information Center

    Zubrzycki, Jaclyn

    2013-01-01

    As groups representing local and state education players struggle to remain relevant in a policy conversation often dominated by foundations, think tanks, new advocacy groups, and political and business figures, a shift in leadership has been under way at major associations. Most of the changes have come as part of the natural churn; former…

  13. Anthropometric changes and fluid shifts

    NASA Technical Reports Server (NTRS)

    Thornton, W. E.; Hoffler, G. W.; Rummel, J. A.

    1974-01-01

    Several observations of body size, shape, posture, and configuration were made to document changes resulting from direct effects of weightlessness during the Skylab 4 mission. After the crewmen were placed in orbit, a number of anatomical and anthropometric changes occurred including a straightening of the thoracolumbar spine, a general decrease in truncal girth, and an increase in height. By the time of the earliest in-flight measurement on mission day 3, all crewmen had lost more than two liters of extravascular fluid from the calf and thigh. The puffy facies, the bird legs effect, the engorgement of upper body veins, and the reduced volume of lower body veins were all documented with photographs. Center-of-mass measurements confirmed a fluid shift cephalad. This shift remained throughout the mission until recovery, when a sharp reversal occurred; a major portion of the reversal was completed in a few hours. The anatomical changes are of considerable scientific interest and of import to the human factors design engineer, but the shifts of blood and extravascular fluid are of more consequence. It is hypothesized that the driving force for the fluid shift is the intrinsic and unopposed lower limb elasticity that forces venous blood and then other fluid cephalad.

  14. Illinois Shifting Gears Policy Evaluation

    ERIC Educational Resources Information Center

    Weitzel, Peter C.

    2009-01-01

    Illinois Shifting Gears is a multilevel initiative that has simultaneously created bridge programs in the field and altered state policy to facilitate the creation of more programs in the future. These efforts have informed each other, giving policymakers the opportunity to interact with practitioners, troubleshoot bridge programs, and make…

  15. Technology Counts 2012: Virtual Shift

    ERIC Educational Resources Information Center

    Education Week, 2012

    2012-01-01

    Virtual education is moving into that intersection where rising popularity meets calls for greater accountability. How the virtual education movement responds to those calls will have a significant impact on how it evolves in K-12 over the next five to 10 years. This report tackles this shift in the virtual education landscape. It examines the…

  16. The Shift Needed for Sustainability

    ERIC Educational Resources Information Center

    Smith, Peter A. C.; Sharicz, Carol

    2011-01-01

    Purpose: The purpose of this action research is to begin to assess to what extent organizations have in practice begun to make the shift towards triple bottom line (TBL) sustainability. Design/methodology/approach: A definition of TBL sustainability is provided, and key elements of TBL sustainability considered necessary to success are identified…

  17. Lamb shift in muonic hydrogen

    SciTech Connect

    Borie, E.

    2005-03-01

    The Lamb shift in muonic hydrogen continues to be a subject of experimental and theoretical investigation. Here my older work on the subject is updated to provide a complementary calculation of the energies of the 2p-2s transitions in muonic hydrogen.

  18. Size-Dependent Raman Shifts for nanocrystals

    PubMed Central

    Gao, Yukun; Zhao, Xinmei; Yin, Penggang; Gao, Faming

    2016-01-01

    Raman spectroscopy is a very sensitive tool for probing semiconductor nanocrystals. The underlying mechanism behind the size-dependent Raman shifts is still quite controversial. Here we offer a new theoretical method for the quantum confinement effects on the Raman spectra of semiconductor nanocrystals. We propose that the shift of Raman spectra in nanocrystals can result from two overlapping effects: the quantum effect shift and surface effect shift. The quantum effect shift is extracted from an extended Kubo formula, the surface effect shift is determined via the first principles calculations. Fairly good prediction of Raman shifts can be obtained without the use of any adjustable parameter. Closer analysis shows that the size-dependent Raman shifts in Si nanocrystals mainly result from the quantum effect shifts. For nanodiamond, the proportion of surface effect shift in Raman shift is up to about 40%. Such model can also provide a good baseline for using Raman spectroscopy as a tool to measure size. PMID:27102066

  19. Doppler phase shifting using dual, switched phase shifting devices

    NASA Technical Reports Server (NTRS)

    Gutierrez, Roman C. (Inventor)

    2002-01-01

    A system of inducing a phase shift using moving reflector elements. The moving reflectors can be moving mirrors or an acousto-optical filter. The moving reflectors oscillate i.e. the move first in a first direction and then in a second direction. Two different reflectors are used so that the light can be switched between the reflectors. During a first portion of the cycle the light is coupled to the first modulator which moves the reflector in the first direction. The second modulator is out of phase with the first modulator, and the light is switched to that second modulator during a second portion of the cycle. The second modulator is also moving in the first direction when the light is applied thereto. In this way, the light obtains a constant direction Doppler shift.

  20. Guide to good practices for shift routines and operating practices

    SciTech Connect

    1998-12-01

    This Guide to Good Practices is written to enhance understanding of, and provide direction for, ``Shift Routines and Operating Practices,`` Chapter 2 of Department of Energy (DOE) Order 5480.19, Conduct of Operations Requirements for DOE Facilities. The practices in this guide should be considered when planning or reviewing shift routines and operating practices. ``Shift Routines and Operating Practices`` is an element of an effective Conduct of Operations program. The complexity and array of activities performed in DOE facilities dictate the necessity for a high standard of professional conduct and sound operating practices to promote safe and efficient operations. Recently, guidance pertaining to this element has been strengthened for nuclear power reactors. This additional guidance is given in Appendix C for information purposes. Though this guidance and good practices pertain to nuclear power reactors, DOE sites may choose to use a graded approach for implementing these in nuclear facilities.

  1. Anthropometric changes and fluid shifts

    NASA Technical Reports Server (NTRS)

    Thornton, W. E.; Hoffler, G. W.; Rummel, J. A.

    1977-01-01

    In an effort to obtain the most comprehensive and coherent picture of changes under weightlessness, a set of measurements on Skylab 2 was initiated and at every opportunity, additional studies were added. All pertinent information from ancillary sources were gleaned and collated. On Skylab 2, the initial anthropometric studies were scheduled in conjunction with muscle study. A single set of facial photographs was made in-flight. Additional measurements were made on Skylab 3, with photographs and truncal and limb girth measurements in-flight. Prior to Skylab 4, it was felt there was considerable evidence for large and rapid fluid shifts, so a series of in-flight volume and center of mass measurements and infrared photographs were scheduled to be conducted in the Skylab 4 mission. A number of changes were properly documented for the first time, most important of which were the fluid shifts. The following description of Skylab anthropometrics address work done on Skylab 4 primarily.

  2. Lamb shift in muonic deuterium

    SciTech Connect

    Gorchtein, Mikhail; Vanderhaeghen, Marc; Carlson, Carl E.

    2013-11-07

    We consider the two-photon exchange contribution to the 2P-2S Lamb shift in muonic deuterium in the framework of forward dispersion relations. The dispersion integrals are evaluated with minimal model dependence using experimental data on elastic deuteron form factors and inelastic electron-deuteron scattering, both in the quasielastic and hadronic range. The subtraction constant that is required to ensure convergence of the dispersion relation for the forward Compton amplitude T{sub 1} (ν,Q{sup 2}) is related to the deuteron magnetic polarizability β(Q{sup 2}) and represents the main source of uncertainty in our analysis. We obtain for the Lamb shift ΔE{sub 2P-2S} = 1.620±0.190 meV and discuss ways to further reduce this uncertainty.

  3. Looping through the Lamb Shift

    SciTech Connect

    Hazi, A U

    2007-02-06

    Sometimes in science, a small measurement can have big ramifications. For a team of Livermore scientists, such was the case when they measured a small shift in the spectrum of extremely ionized atoms of uranium. The measurement involves the Lamb shift, a subtle change in the energy of an electron orbiting an atom's nucleus. The precision of the Livermore result was 10 times greater than that of existing measurements, making it the best measurement to date of a complicated correction to the simplest quantum description of how atoms behave. The measurement introduces a new realm in the search for deviations between the theory of quantum electrodynamics (QED), which is an extension of quantum mechanics, and the real world. Such deviations, if discovered, would have far-reaching consequences, indicating that QED is not a fundamental theory of nature.

  4. KVI Lamb-shift polarimeter

    SciTech Connect

    Beijers, J.P.M.; Kremers, H.R.; Kalantar-Nayestanaki, N.

    2006-03-15

    The design and operation of a Lamb-shift polarimeter is discussed. This polarimeter is used to measure the polarization of proton and deuteron beams extracted from the KVI polarized-ion source. The major components of the Lamb-shift polarimeter (LSP) are described in some detail. These include the deceleration lens system, cesium neutralization oven, spin filter, metastable-atom detection system, and the solenoid. Typical operating parameters of the LSP will be given together with some representative spin-polarization measurements. The design criterion of measuring the polarization of a H{sup +} or D{sup +} beam within 60 s and with a statistical uncertainty smaller than 2% has been met.

  5. Multicolor Holography With Phase Shifting

    NASA Technical Reports Server (NTRS)

    Vikram, Chandra S.

    1996-01-01

    Prototype apparatus constructed to test feasibility of two-color holographic interferometric scheme in which data for reconstructing holographic wavefront obtained with help of phase-shifting technique. Provides two sets of data needed to solve equations for effects of temperature and concentration. Concept extended to holography at three or more wavelengths to measure three or more phenomena associated with significant variations in index of refraction

  6. Shift and Scale Invariant Preprocessor.

    DTIC Science & Technology

    1981-12-01

    1982 THESIS D V SHIFT AND SCALE INVARIANT ?PREPROCESSOR by Norman E. Huston, Jr. December 1981 0 Thesis Advisor: L. A. Wilson Approved for public...SCHOOL December 1981 Author: - . 4 ,/ A pp ro0ved by: rYY. ( Thesis Advisor Co-Ad isor Chairman, De artment of 4n n eing Dean of Science and...large range of problems/disciplines. Fields where it is particularly common include optical imagery, acoustic signal processing , radiology, radio

  7. Generalized phase-shifting color digital holography

    NASA Astrophysics Data System (ADS)

    Nomura, Takanori; Kawakami, Takaaki; Shinomura, Kazuma

    2016-06-01

    Two methods to apply the generalized phase-shifting digital holography to color digital holography are proposed. One is wave-splitting generalized phase-shifting color digital holography. This is realized by using a color Bayer camera. Another is multiple exposure generalized phase-shifting color digital holography. This is realized by the wavelength-dependent phase-shifting devices. Experimental results for both generalized phase-shifting color digital holography are presented to confirm the proposed methods.

  8. Frequency shifts in gravitational resonance spectroscopy

    DOE PAGES

    Baeßler, S.; Nesvizhevsky, V. V.; Pignol, G.; ...

    2015-02-25

    Quantum states of ultracold neutrons in a gravitational field are characterized through gravitational resonance spectroscopy. This paper discusses systematic effects that appear in the spectroscopic measurements. The discussed frequency shifts-which we call the Stern-Gerlach shift, interference shift, and spectator-state shift-appear in conceivable measurement schemes and have general importance. Lastly, these shifts have to be taken into account in precision experiments.

  9. Strategies for brain shift evaluation.

    PubMed

    Hastreiter, Peter; Rezk-Salama, Christof; Soza, Grzegorz; Bauer, Michael; Greiner, Günther; Fahlbusch, Rudolf; Ganslandt, Oliver; Nimsky, Christopher

    2004-12-01

    For the analysis of the brain shift phenomenon different strategies were applied. In 32 glioma cases pre- and intraoperative MR datasets were acquired in order to evaluate the maximum displacement of the brain surface and the deep tumor margin. After rigid registration using the software of the neuronavigation system, a direct comparison was made with 2D- and 3D visualizations. As a result, a great variability of the brain shift was observed ranging up to 24 mm for cortical displacement and exceeding 3 mm for the deep tumor margin in 66% of all cases. Following intraoperative imaging the neuronavigation system was updated in eight cases providing reliable guidance. For a more comprehensive analysis a voxel-based nonlinear registration was applied. Aiming at improved speed of alignment we performed all interpolation operations with 3D texture mapping based on OpenGL functions supported in graphics hardware. Further acceleration was achieved with an adaptive refinement of the underlying control point grid focusing on the main deformation areas. For a quick overview the registered datasets were evaluated with different 3D visualization approaches. Finally, the results were compared to the initial measurements contributing to a better understanding of the brain shift phenomenon. Overall, the experiments clearly demonstrate that deformations of the brain surface and deeper brain structures are uncorrelated.

  10. Shift work and endocrine disorders.

    PubMed

    Ulhôa, M A; Marqueze, E C; Burgos, L G A; Moreno, C R C

    2015-01-01

    The objective of this review was to investigate the impact of shift and night work on metabolic processes and the role of alterations in the sleep-wake cycle and feeding times and environmental changes in the occurrence of metabolic disorders. The literature review was performed by searching three electronic databases for relevant studies published in the last 10 years. The methodological quality of each study was assessed, and best-evidence synthesis was applied to draw conclusions. The literature has shown changes in concentrations of melatonin, cortisol, ghrelin, and leptin among shift workers. Melatonin has been implicated for its role in the synthesis and action of insulin. The action of this hormone also regulates the expression of transporter glucose type 4 or triggers phosphorylation of the insulin receptor. Therefore, a reduction in melatonin can be associated with an increase in insulin resistance and a propensity for the development of diabetes. Moreover, shift work can negatively affect sleep and contribute to sedentarism, unhealthy eating habits, and stress. Recent studies on metabolic processes have increasingly revealed their complexity. Physiological changes induced in workers who invert their activity-rest cycle to fulfill work hours include disruptions in metabolic processes.

  11. Chemical Shift Anisotropy Selective Inversion*

    PubMed Central

    Caporini, Marc. A.; Turner, Christopher. J.; Bielecki, Anthony; Griffin, Robert G.

    2009-01-01

    Magic Angle Spinning (MAS) is used in solid-state NMR to remove the broadening effects of the chemical shift anisotropy (CSA). In this work we investigate a technique that can reintroduce the CSA in order to selectively invert transverse magnetization. The technique involves an amplitude sweep of the radio frequency field through a multiple of the spinning frequency. The selectivity of this inversion mechanism is determined by the size of the CSA. We develop a theoretical framework to describe this process and demonstrate the CSA selective inversion with numerical simulations and experimental data. We combine this approach with cross polarization (CP) for potential applications in multi-dimensional MAS NMR. PMID:19648036

  12. Phase-shifting Gabor holography.

    PubMed

    Micó, Vicente; García, Javier; Zalevsky, Zeev; Javidi, Bahram

    2009-05-15

    We present a modified Gabor-like setup able to recover the complex amplitude distribution of the object wavefront from a set of inline recorded holograms. The proposed configuration is characterized by the insertion of a condenser lens and a spatial light modulator (SLM) into the classical Gabor configuration. The phase shift is introduced by the SLM that modulates the central spot (dc term) in an intermediate plane, without an additional reference beam. Experimental results validate the proposed method and produce superior results to the Gabor method.

  13. Geometric phase shifting digital holography.

    PubMed

    Jackin, Boaz Jessie; Narayanamurthy, C S; Yatagai, Toyohiko

    2016-06-01

    A new phase shifting digital holographic technique using a purely geometric phase in Michelson interferometric geometry is proposed. The geometric phase in the system does not depend upon either optical path length or wavelength, unlike dynamic phase. The amount of geometric phase generated is controllable through a rotating wave plate. The new approach has unique features and major advantages in holographic measurement of transparent and reflecting three-dimensional (3D) objects. Experimental results on surface shape measurement and imaging of 3D objects are presented using the proposed method.

  14. Sectoral shifts and aggregate unemployment

    SciTech Connect

    Loungani, P.

    1986-01-01

    Some recent research has taken the view that sectoral or industry-specific shocks significantly affect aggregate unemployment by increasing the amount of inter-industry labor reallocation required. The empirical evidence for this view rests on the finding that during the 1950s - and again during the 1970s - there was a positive correlation between aggregate unemployment and the dispersion of employment growth rates. This thesis demonstrates that this correlation arises largely because oil price shocks affect both unemployment and the dispersion of employment growth. Once the dispersion due to oil shocks is accounted for, the residual dispersion in employment has very low explanatory power for unemployment. Since the dispersion index does not measure pure sectoral shifts, an alternate measure of dispersion is developed that serves as a better proxy for the amount of inter-industry labor reallocation required each period. Estimates using this measure suggest that, during the 1950s, temporary increases in the relative price of oil were responsible for generating the observed correlation. On the other hand, sectoral shifts were important during the 1970s; in particular, the 1973 oil price increase has had significant reallocative effects on the economy. This contention is subjected to further tests by looking at the time-series behavior of employment in durable-goods industries and also by following the inter-industry movements of workers over time through the use of panel data.

  15. Does Learning-Centered Teaching Promote Grade Improvement?

    ERIC Educational Resources Information Center

    Mostrom, Alison M.; Blumberg, Phyllis

    2012-01-01

    When the grade distribution within a course shifts towards higher grades, it may be due to grade inflation or grade improvement. If the positive shift is accompanied by an increase in achievement or learning, it should be considered grade improvement, "not" grade inflation. Effective learning-centered teaching is designed to promote student…

  16. TBT causes regime shift in shallow lakes.

    PubMed

    Sayer, Carl D; Hoare, Daniel J; Simpson, Gavin L; Henderson, Andrew C G; Liptrot, Eleanor R; Jackson, Michael J; Appleby, Peter G; Boyle, John F; Jones, I Iwan; Waldock, Mike J

    2006-09-01

    Tributyltin (TBT) is an organotin compound used since the early 1960s as a biocide in boat antifouling paints. Its use has been linked to a host of negative effects in marine ecosystems including malformations and imposex in Mollusca and acute toxicity in many other aquatic animals. Yet, the consequences of TBT use in freshwaters are largely unknown. Here, for the first time we reveal that TBT may have caused hitherto unsuspected damage to freshwater ecosystems. Through an analysis of dated sediment cores collected from a system of recreationally boated, shallow lakes, we show that first evidence of TBT is associated with a dramatic loss of submerged vegetation and associated diverse animal communities. Cause and effect are difficult to unravel in our study. However, we hypothesize that TBT, through reducing populations of grazing organisms in lakes already affected by eutrophication, promoted the replacement of macrophytes by phytoplankton, ultimately leading to a regime shift in the ecosystem. Our findings may have parallels in freshwater ecosystems all over the world.

  17. Shift register generators and applications to coding

    NASA Technical Reports Server (NTRS)

    Morakis, J. C.

    1968-01-01

    The most important properties of shift register generated sequences are exposed. The application of shift registers as multiplication and division circuits leads to the generation of some error correcting and detecting codes.

  18. Newtonian normal shift in multidimensional Riemannian geometry

    SciTech Connect

    Sharipov, Ruslan A

    2001-06-30

    An explicit description of all Newtonian dynamical systems admitting normal shift in Riemannian manifolds of dimension n{>=}3 is obtained. On this basis the kinematics of the normal shift of hypersurfaces along trajectories of such dynamical systems is studied.

  19. Understanding covariate shift in model performance

    PubMed Central

    McGaughey, Georgia; Walters, W. Patrick; Goldman, Brian

    2016-01-01

    Three (3) different methods (logistic regression, covariate shift and k-NN) were applied to five (5) internal datasets and one (1) external, publically available dataset where covariate shift existed. In all cases, k-NN’s performance was inferior to either logistic regression or covariate shift. Surprisingly, there was no obvious advantage for using covariate shift to reweight the training data in the examined datasets. PMID:27803797

  20. Promoting Retention

    PubMed Central

    Hall, LaToya N.; Ficker, Lisa J.; Chadiha, Letha A.; Green, Carmen R.; Jackson, James S.; Lichtenberg, Peter A.

    2016-01-01

    Objectives: The objectives of this study were to evaluate the capability of a research volunteer registry to retain community-dwelling African American older adults, and to explore demographic and health factors associated with retention. Method: A logistic regression model was used to determine the influence of demographics, health factors, and registry logic model activities on retention in a sample of 1,730 older African American adults. Results: Almost 80% of participants active in the volunteer research registry between January 2012 and June 2015 were retained. Employment, being referred to research studies, a higher number of medical conditions, and more follow-up contacts were associated with an increased likelihood of retention. Older age, more months in the registry, and more mobility problems decreased the likelihood of retention. Discussion: These results suggest the Michigan Center for Urban African American Aging Research logic model promotes retention through involving older African American adults in research through study referrals and intensive follow-up. The loss of participants due to age- and mobility-related issues indicate the registry may be losing its most vulnerable participants. PMID:28138501

  1. Continuous-data FIFO bubble shift register

    NASA Technical Reports Server (NTRS)

    Chen, T. T.

    1977-01-01

    Simple loop first-in-first-out (FIFO) bubble memory shift register has continuous storage capability. Bubble shift register simplifies chip-control electronics by enabling all control functions to be alined at same bit. FIFO shift register is constructed from passive replicator and annihilator combinations.

  2. Mean shift is a bound optimization.

    PubMed

    Fashing, Mark; Tomasi, Carlo

    2005-03-01

    We build on the current understanding of mean shift as an optimization procedure. We demonstrate that, in the case of piecewise constant kernels, mean shift is equivalent to Newton's method. Further, we prove that, for all kernels, the mean shift procedure is a quadratic bound maximization.

  3. Setting the Standard: The Characteristics & Consequences of Alternative Student Promotional Policies.

    ERIC Educational Resources Information Center

    Labaree, David F.

    Examining student promotion standards in American education, the author reviews the origins and history of the shift between merit promotion (which advances students based on demonstrated skill competence) and social promotion (which advances students in response to their social needs). Case studies of promotional policies are provided for schools…

  4. Time evolution of the Lamb shift.

    PubMed

    Wang, Da-Wei; Li, Zheng-Hong; Wang, Li-Gang; Zhu, Shi-Yao; Zubairy, M Suhail

    2010-09-01

    The time evolution of the Lamb shift that accompanies the real photon emission is studied for the first time (to our knowledge). The investigation of the explicit time dependence of the Lamb shift becomes possible because the self-energy of the free electron, which is divergent, is subtracted from the Hamiltonian after a unitary transformation. The Lamb shift can then be separated into two parts: one is the time-independent shift due to the virtual photon exchange, and the other is the time-dependent shift due to the real photon emission. The time evolution depends on the nature of the coupling spectrum of the reservoir.

  5. AGE restriction in diabetes mellitus: a paradigm shift.

    PubMed

    Vlassara, Helen; Striker, Gary E

    2011-05-24

    Persistently elevated oxidative stress and inflammation precede or occur during the development of type 1 or type 2 diabetes mellitus and precipitate devastating complications. Given the rapidly increasing incidence of diabetes mellitus and obesity in the space of a few decades, new genetic mutations are unlikely to be the cause, instead pointing to environmental initiators. A hallmark of contemporary culture is a preference for thermally processed foods, replete with pro-oxidant advanced glycation endproducts (AGEs). These molecules are appetite-increasing and, thus, efficient enhancers of overnutrition (which promotes obesity) and oxidant overload (which promotes inflammation). Studies of genetic and nongenetic animal models of diabetes mellitus suggest that suppression of host defenses, under sustained pressure from food-derived AGEs, may potentially shift homeostasis towards a higher basal level of oxidative stress, inflammation and injury of both insulin-producing and insulin-responsive cells. This sequence promotes both types of diabetes mellitus. Reducing basal oxidative stress by AGE restriction in mice, without energy or nutrient change, reinstates host defenses, alleviates inflammation, prevents diabetes mellitus, vascular and renal complications and extends normal lifespan. Studies in healthy humans and in those with diabetes mellitus show that consumption of high amounts of food-related AGEs is a determinant of insulin resistance and inflammation and that AGE restriction improves both. This Review focuses on AGEs as novel initiators of oxidative stress that precedes, rather than results from, diabetes mellitus. Therapeutic gains from AGE restriction constitute a paradigm shift.

  6. Gear-shift mechanism for manual transmission

    SciTech Connect

    Fukuchi, H.

    1986-07-22

    This patent describes a gear-shift mechanism for a manual transmission comprising a housing for the transmission; a movable shaft mounted in place within the housing for both axial and rotary movements and being operatively connected to a manual shift lever to be axially shifted from its neutral position to a forward or reverse position in selecting operation of the manual shift lever and to be rotated at its shifted position in shifting operation of the manual shift lever; a shift-and-select lever fixed to an intermediate portion of the movable shaft; an interlock member rotatably mounted in place on the movable shaft and having a pair of interlock arms located at the opposite sides of the shift-and-select lever; means for restricting rotary movement of the interlock member and permitting axial movement of the same; a pair of resilient means for centering the movable shaft to retain the shift-and-select lever and the interlock member in their neutral positions; and first, second and third shift heads arranged in sequence within the housing.

  7. Reverse shift mechanism for automotive manual transmission

    SciTech Connect

    Inui, M.; Ogawa, S.

    1987-03-03

    A reverse shift mechanism is described for an automotive manual transmission of a type having a reverse idler gear which is movable to selectively complete a reverse gear train, the reverse shift mechanism comprising: a reverse shift arm having a portion disposed adjacent the reverse idler gear and pivotally carried with respect to a transmission casing so that the portion rocks along a direction of axis of the reverse idler gear in response to shifting operation. The portion of the reverse shift arm is provided with a blind hole which is open at a first end toward the reverse idler gear and is closed at a second end away from the reverse idler gear; and a shift arm shoe carried by the portion of the reverse shift arm adjacent the reverse idler gear for pushing the reverse idler gear. The shift arm shoe has an end adapted to engage with a circumferential groove formed in the reverse idler gear and an opposing end shaped to fit in the blind hole of the reverse shift arm; whereby the shift arm shoe is prevented from coming off during assembly by virtue of a vacuum effect created by air confined in the blind hole by fitting engagement between the opposing end and the blind hole, and is held in place after assembly by being clamped between the groove of the reverse idler gear and the blind hole of the reverse shift arm.

  8. Paradigm shift in lead design.

    PubMed

    Irnich, W

    1999-09-01

    During the past 30 years there has been a tremendous development in electrode technology from bulky (90 mm2) to pin-sized (1.0 mm2) electrodes. Simultaneously, impedance has increased from 110 Ohms to >1 kOhms, which has been termed a "paradigm shift" in lead design. If current is responsible for stimulation, why is its impedance a key factor in saving energy? Further, what mechanism is behind this development based on experimental findings and what conclusion can be drawn from it to optimize electrode size? If it is assumed that there is always a layer of nonexcitable tissue between the electrode surface and excitable myocardium and that the electric field (potential gradient) produced by the electrode at this boundary is reaching threshold level, then a formula can be derived for the voltage threshold that completely describes the electrophysiology and electrophysics of a hemispherical electrode. Assuming that the mean chronic threshold for porous steroid-eluting electrodes is 0.6 V with 0.5-ms pulse duration, thickness of nonexcitable tissue can be estimated to be 1.5 mm. Taking into account this measure and the relationship between chronaxie and electrode area, voltage threshold, impedance, and energy as a function of surface area can be calculated. The lowest voltage for 0.5-ms pulse duration is reached with r(o) = 0.5 d, yielding a surface area of 4 mm2 and a voltage threshold of 0.62 V, an impedance of 1 kOhms, and an energy level of 197 nJ. It can be deduced from our findings that a further reduction of surface areas below 1.6 mm2 will not diminish energy threshold substantially, if pulse duration remains at 0.5 ms. Lowest energy is reached with t = chronaxie, yielding an energy level <100 nJ with surface areas < or =1.5 mm2. It is striking to see how well the theoretically derived results correspond to the experimental findings. It is also surprising that the hemispheric model so accurately approximates experimental results with differently shaped

  9. Dietary and lifestyle habits and the associated health risks in shift workers.

    PubMed

    Nea, Fiona M; Kearney, John; Livingstone, M Barbara E; Pourshahidi, L Kirsty; Corish, Clare A

    2015-12-01

    Traditionally only a small proportion of the workforce was engaged in shift work. Changing economic pressures have resulted in increased engagement in shift work, with approximately 17 % of the workforce in Europe engaged in this work pattern. The present narrative review aimed to summarise the data on the effects of shift work on the diet, lifestyle and health of employees, while addressing the barriers to, and opportunities for, improving health among shift workers. Shift work can result in low-quality diet and irregular eating patterns. Adverse health behaviours are also reported; particularly increased smoking and poor sleep patterns. These altered lifestyle habits, in conjunction with disruption to circadian rhythms, can create an unfavourable metabolic phenotype which facilitates the development and progression of chronic disease. Although the data are inconclusive due to issues such as poor study design and inadequate control for confounding factors; shift workers appear to be at increased mental and physical health risk, particularly with regard to non-communicable diseases. Information is lacking on the obstacles to leading a healthier lifestyle while working shifts, and where opportunities lie for intervention and health promotion among this group. In order to provide an informed evidence base to assist shift workers in overcoming associated occupational hazards, this gap must be addressed. This review highlights the unique nutritional issues faced by shift workers, and the subsequent effect on health. In societies already burdened with increased incidence of non-communicable chronic diseases, there is a clear need for education and behaviour change interventions among this group.

  10. Dealing with a Paradigm Shift

    PubMed Central

    Pack, Allan I.

    2015-01-01

    Recent changes in policies by insurance companies with respect to mandating home sleep apnea testing rather than in-laboratory studies have a large impact on the financial viability of clinical sleep centers. Coping with this disruptive change requires forward planning. First, it is important to be well positioned with respect to facilities so that these can be quickly downsized to control costs. There is also a need to develop, in advance, an accredited home sleep study program so that centers can respond to the rapidly changing environment. Following the change there is a need to control costs by rapidly downsizing the technology workforce. Technologists can be retrained for other essential roles. Centralizing the precertification process with knowledgeable, well-trained staff and a robust auditing process is an essential component. The approach taken at the University of Pennsylvania to this change is described as is how one can ensure continued financial viability of a comprehensive sleep center program in a major academic medical center. Citation: Pack AI. Dealing with a paradigm shift. J Clin Sleep Med 2015;11(8):925–929. PMID:26094918

  11. Shifting boundaries in professional care.

    PubMed

    Hopkins, A; Solomon, J; Abelson, J

    1996-07-01

    The nature of the work undertaken by different health professionals and inter-professional boundaries are constantly shifting. The greater knowledge of users of health care, and the increasing technical and organizational complexity of modern medicine, have partly eroded the control of health professionals over the substance of their work. The definition of a field of work as lying within the province of any one profession is culturally rather than scientifically determined. It is evident that care of good quality should be delivered at the lowest possible cost. This might include delivery of care by a less trained person than heretofore, or by someone with limited but focused training. Sharing of skills is a more sensible subject for discussion than transfer of tasks. We review a number of studies which show the effectiveness of inter-professional substitution in various care settings, and also the effectiveness of substitution by those other than health professionals. The views of users of health services on inter-professional substitution need to be considered. Health professionals and others need to work together to devise innovative ways of delivering effective health care. The legal issues need clarification.

  12. Shifting boundaries in professional care.

    PubMed Central

    Hopkins, A; Solomon, J; Abelson, J

    1996-01-01

    The nature of the work undertaken by different health professionals and inter-professional boundaries are constantly shifting. The greater knowledge of users of health care, and the increasing technical and organizational complexity of modern medicine, have partly eroded the control of health professionals over the substance of their work. The definition of a field of work as lying within the province of any one profession is culturally rather than scientifically determined. It is evident that care of good quality should be delivered at the lowest possible cost. This might include delivery of care by a less trained person than heretofore, or by someone with limited but focused training. Sharing of skills is a more sensible subject for discussion than transfer of tasks. We review a number of studies which show the effectiveness of inter-professional substitution in various care settings, and also the effectiveness of substitution by those other than health professionals. The views of users of health services on inter-professional substitution need to be considered. Health professionals and others need to work together to devise innovative ways of delivering effective health care. The legal issues need clarification. PMID:8774532

  13. Shifting Baselines, Science, and Society

    NASA Astrophysics Data System (ADS)

    Jackson, J. B.

    2006-12-01

    All of us have a deeply personal concept of nature based upon our childhood perceptions of the world around us, and of the subsequent degradation of nature by the experiences of our lifetimes. Yet even the most rudimentary knowledge of history clearly demonstrates that the modern rise of human population and consumption have wreaked havoc on global ecosystems to the extent that nowhere is close to natural or pristine and that most places have been increasingly degraded over many centuries. This disconnect between direct personal experience and abstract historical perspective is the problem of "shifting baselines" that is the fundamental impediment to basic scientific understanding and environmental policy, and affects scientists as much as the general public, business, and government. Scientists in particular suffer from the inability to directly observe and experimentally verify causes and effects of previous changes in ecosystems that now bear so little resemblance to their natural state. Under the circumstances, it is essential for scientists to draw scientific conclusions based on imperfect data and to publicly explain, defend, and discuss their conclusions as the best possible science given present information. The failure to do so makes science virtually irrelevant to social and environmental policy and government.

  14. HU multimerization shift controls nucleoid compaction

    PubMed Central

    Hammel, Michal; Amlanjyoti, Dhar; Reyes, Francis E.; Chen, Jian-Hua; Parpana, Rochelle; Tang, Henry Y. H.; Larabell, Carolyn A.; Tainer, John A.; Adhya, Sankar

    2016-01-01

    Molecular mechanisms controlling functional bacterial chromosome (nucleoid) compaction and organization are surprisingly enigmatic but partly depend on conserved, histone-like proteins HUαα and HUαβ and their interactions that span the nanoscale and mesoscale from protein-DNA complexes to the bacterial chromosome and nucleoid structure. We determined the crystal structures of these chromosome-associated proteins in complex with native duplex DNA. Distinct DNA binding modes of HUαα and HUαβ elucidate fundamental features of bacterial chromosome packing that regulate gene transcription. By combining crystal structures with solution x-ray scattering results, we determined architectures of HU-DNA nucleoproteins in solution under near-physiological conditions. These macromolecular conformations and interactions result in contraction at the cellular level based on in vivo imaging of native unlabeled nucleoid by soft x-ray tomography upon HUβ and ectopic HUα38 expression. Structural characterization of charge-altered HUαα-DNA complexes reveals an HU molecular switch that is suitable for condensing nucleoid and reprogramming noninvasive Escherichia coli into an invasive form. Collective findings suggest that shifts between networking and cooperative and noncooperative DNA-dependent HU multimerization control DNA compaction and supercoiling independently of cellular topoisomerase activity. By integrating x-ray crystal structures, x-ray scattering, mutational tests, and x-ray imaging that span from protein-DNA complexes to the bacterial chromosome and nucleoid structure, we show that defined dynamic HU interaction networks can promote nucleoid reorganization and transcriptional regulation as efficient general microbial mechanisms to help synchronize genetic responses to cell cycle, changing environments, and pathogenesis. PMID:27482541

  15. Electromagnetic tracking of the pivot-shift.

    PubMed

    Kuroda, Ryosuke; Hoshino, Yuichi

    2016-06-01

    The pivot-shift test is an important examination to assess the rotational laxity in the anterior cruciate ligament (ACL) injured and reconstructed knees. Because this examination is related to subjective knee function, we may still see cases that have residual rotational laxity after ACL reconstruction. Quantitative evaluation of the pivot-shift test is preferable to the clinical pivot-shift test but is difficult to attain mainly due to complicated movements of the pivot-shift. The electromagnetic tracking system was developed to evaluate knee kinematics during the pivot-shift, providing information related to 6-degree-of-freedom knee kinematics with a high sampling rate. Through this device, the abnormal movement of the pivot-shift is characterized in two phases: an increased anterior tibial translation and a boosted acceleration of tibial posterior reduction. Since its invention, this system has been utilized to assess rotational laxity for clinical follow-up and research after the ACL reconstruction.

  16. Host shifts and evolutionary radiations of butterflies.

    PubMed

    Fordyce, James A

    2010-12-22

    Ehrlich and Raven proposed a model of coevolution where major host plant shifts of butterflies facilitate a burst of diversification driven by their arrival to a new adaptive zone. One prediction of this model is that reconstructions of historical diversification of butterflies should indicate an increase in diversification rate following major host shifts. Using reconstructed histories of 15 butterfly groups, I tested this prediction and found general agreement with Ehrlich and Raven's model. Butterfly lineages with an inferred major historical host shift showed evidence of diversification rate variation, with a significant acceleration following the host shift. Lineages without an inferred major host shift generally agreed with a constant-rate model of diversification. These results are consistent with the view that host plant associations have played a profound role in the evolutionary history of butterflies, and show that major shifts to chemically distinct plant groups leave a historical footprint that remains detectable today.

  17. EUVL alternating phase shift mask

    NASA Astrophysics Data System (ADS)

    Yan, Pei-Yang; Myers, Alan; Shroff, Yashesh; Chandhok, Manish; Zhang, Guojing; Gullikson, Eric; Salmassi, Farhad

    2011-04-01

    Extreme ultra-violet Lithography (EUVL) alternating phase shift mask (APSM) or other optical enhancement techniques are likely needed for 16nm (half pitch) technology generation and beyond. One possible option is the combination of EUVL and APSM. The fabrication of EUVL APSM is more difficult than either the fabrication of an EUVL binary mask or a conventional optical APSM mask. In the case of EUVL APSM, the phase difference in the two regions (0 and 180-degree phase regions) is created by a phase step in the substrate prior to the multilayer (ML) coating. The step height that induces 180-degree phase mismatch in the ML is determined by [λ/(4cosθ)](2m+1), where m are integers (0, 1, 2,...). In this experiment, we targeted for a step height with m=1. The same mask design also contains the standard binary structures so that the comparison between the EUVL APSM and the EUVL binary mask can be performed under the same illumination and wafer process conditions. The EUVL APSM mask was exposed using Nikon's EUV1 scanner in Kumagaya Japan. The wafer level results showed higher dense line resolution for EUVL APSM as compared to that of EUVL binary mask. APSM also showed improved line width roughness (LWR) and depth of focus (DoF) as compared to the best EUVL binary results obtained with C-dipole off-axis illumination (OAI). The wafer CD resolution improvement obtained by APSM in this experiment is partially limited by the resist resolution and the mask phase edge spread during ML deposition. We believe that wafer CD resolution and can further be improved with imaging imbalance compensation mask design and improvements in resist resolution and the phase generation portion of the mask fabrication process. In this paper, we will discuss in detail the mask fabrication process, wafer level data analysis, and our understanding of EUVL APSM related issues.

  18. Shift mechanism for engine starting apparatus

    SciTech Connect

    Colvin, J.A.; Colvill, R.G.; Smock, A.L.

    1986-04-01

    This patent describes a shift lever mechanism for translating axial movement of the plunger of a starter solenoid into axial movement of a pinion of an engine starting apparatus. This apparatus consists of, a starter solenoid having an axially shiftable plunger and a coil winding, a spring opposing pull-in movement of the plunger and a solenoid switch operated to a closed condition when the plunger is completely pulled-in, a shift lever actuator carried by the plunger for axial movement therewith. The actuator has a pair of spaced surfaces, a pivotally mounted shift lever one end of which is adapted to be coupled to the pinion. The opposite end of the shift lever has a pair of opposed shift lever surfaces that respectively engage the surfaces on the actuator. The actuator surfaces and the shift lever surfaces are substantially engaged when the shift lever is in an at rest postion. The surfaces on the shift lever are at different radial distances from the pivot point of the shift lever and are arranged relative to the surfaces on the actuator such that when the solenoid plunger pulls-in the surface on the shift lever that is at the greater radial distance from the pivot point is moved by a surface of the actuator and the other surface on the shift lever becomes separated by a predetermined amount from its cooperating surface on the actuator. The amount of separation is sufficient to allow the solenoid switch to be actuated to an open condition when the solenoid coil winding is deenergized and the spring shifts and plunger to reengage the separated surfaces.

  19. Shift multiplexing by planar waveguide referencing

    NASA Astrophysics Data System (ADS)

    Yi, Tao; Zhang, Jiasen; Yan, Lifen; Gong, Qihuang

    2005-09-01

    We present a new method with which to implement shift multiplexing by planar waveguide referencing. In this method, a planar waveguide is used to steer the reference beam, and we implement shift multiplexing by shifting the recording medium. A spatial selectivity as high as 1.1 μm is obtained. By using waveguide referencing we can make a compact and simple holographic system.

  20. Light shifts in atomic Bragg diffraction

    NASA Astrophysics Data System (ADS)

    Giese, E.; Friedrich, A.; Abend, S.; Rasel, E. M.; Schleich, W. P.

    2016-12-01

    Bragg diffraction of an atomic wave packet in a retroreflective geometry with two counterpropagating optical lattices exhibits a light shift induced phase. We show that the temporal shape of the light pulse determines the behavior of this phase shift: In contrast to Raman diffraction, Bragg diffraction with Gaussian pulses leads to a significant suppression of the intrinsic phase shift due to a scaling with the third power of the inverse Doppler frequency. However, for box-shaped laser pulses, the corresponding shift is twice as large as for Raman diffraction. Our results are based on approximate but analytical expressions as well as a numerical integration of the corresponding Schrödinger equation.

  1. Jet Lag and Shift Work Disorder.

    PubMed

    Reid, Kathryn J; Abbott, Sabra M

    2015-12-01

    Jet lag and shift work disorder are circadian rhythm sleep-wake disorders resulting from behaviorally altering the sleep-wake schedule in relation to the external environment. Not everyone who experiences trans-meridian travel or performs shift work has a disorder. The prevalence of jet lag disorder is unclear, approximately 5%-10% of shift workers have shift work disorder. Treatment aims to realign the internal circadian clock with the external environment. Behavioral therapies include sleep hygiene and management of the light-dark and sleep schedule. Pharmacologic agents are used to treat insomnia and excessive sleepiness, and melatonin is used to facilitate sleep and circadian realignment.

  2. Goos-Haenchen shift in complex crystals

    SciTech Connect

    Longhi, Stefano; Della Valle, Giuseppe; Staliunas, Kestutis

    2011-10-15

    The Goos-Haenchen (GH) effect for wave scattering from complex PT-symmetric periodic potentials (complex crystals) is theoretically investigated, with specific reference to optical GH shift in photonic crystal slabs with a sinusoidal periodic modulation of both real and imaginary parts of the dielectric constant. The analysis highlights some distinct and rather unique features as compared to the GH shift found in ordinary crystals. In particular, as opposed to GH shift in ordinary crystals, which is large at the band gap edges, in complex crystals the GH shift can be large inside the reflection (amplification) band and becomes extremely large as the PT symmetry-breaking threshold is approached.

  3. The second-order gravitational red shift

    NASA Technical Reports Server (NTRS)

    Jaffe, J.

    1973-01-01

    The direct measurement of the nonlinear term of the gravitational field equations by using very stable clocks is discussed along with measuring the perhelion advance of a planet or satellite. These are considered measurements of the second-order gravitational red shift. The exact expression for the frequency shift of light in a gravitational field is derived. Other topics discussed include: The Doppler-cancelling technique; the second-order red shift in a spherically symmetric gravitational field; finite signal transit time; and the reality and interpretation of coordinates in the second-order red shift experiment.

  4. Zero difference algorithm for phase shift extraction in blind phase-shifting holography.

    PubMed

    Guo, Cheng-Shan; Sha, Bei; Xie, Yi-Yan; Zhang, Xiu-Jiang

    2014-02-15

    A simple noniterative algorithm for retrieval of the unknown phase shifts in phase-shifting holography is proposed. In this algorithm, the phase shift value between two phase-shifting holograms can be calculated through a simple analytical formula that is derived according to the fact that there exist some points whose intensity difference between two phase-shifting holograms is equal to zero. Both the simulated and experimental results demonstrated the feasibility of this so-called zero difference algorithm over a wide range of phase shifts.

  5. Exercise, energy balance and the shift worker.

    PubMed

    Atkinson, Greg; Fullick, Sarah; Grindey, Charlotte; Maclaren, Don

    2008-01-01

    Shift work is now common in society and is not restricted to heavy industry or emergency services, but is increasingly found amongst 'white collar' occupations and the growing number of service industries. Participation in shift work is associated with increased body mass index, prevalence of obesity and other health problems. We review the behavioural and biological disturbances that occur during shift work and discuss their impact on leisure-time physical activity and energy balance. Shift work generally decreases opportunities for physical activity and participation in sports. For those shift workers who are able to exercise, subjective and biological responses can be altered if the exercise is taken at unusual times of day and/or if the shift worker is sleep deprived. These altered responses may in turn impact on the longer-term adherence to an exercise programme. The favourable effects of exercise on body mass control and sleep quality in shift workers have not been confirmed. Similarly, recent reports of relationships between sleep duration and obesity have not been examined in a shift work context. There is no evidence that exercise can mediate certain circadian rhythm characteristics (e.g. amplitude or timing) for improved tolerance to shift work. Total energy intake and meal composition do not seem to be affected by participation in shift work. Meal frequency is generally reduced but snacking is increased on the night shift. Unavailability of preferred foods in the workplace, a lack of time, and a reduced desire to eat at night explain these findings. 'Normal' eating habits with the family are also disrupted. The metabolic responses to food are also altered by shift work-mediated disruptions to sleep and circadian rhythms. Whether any interactions on human metabolism exist between timing or content of food intake and physical activity during shift work is not known at present. There are very few randomized controlled studies on the efficacy of physical

  6. In-line phase shift tomosynthesis

    SciTech Connect

    Hammonds, Jeffrey C.; Price, Ronald R.; Pickens, David R.; Donnelly, Edwin F.

    2013-08-15

    Purpose: The purpose of this work is to (1) demonstrate laboratory measurements of phase shift images derived from in-line phase-contrast radiographs using the attenuation-partition based algorithm (APBA) of Yan et al.[Opt. Express 18(15), 16074–16089 (2010)], (2) verify that the APBA reconstructed images obey the linearity principle, and (3) reconstruct tomosynthesis phase shift images from a collection of angularly sampled planar phase shift images.Methods: An unmodified, commercially available cabinet x-ray system (Faxitron LX-60) was used in this experiment. This system contains a tungsten anode x-ray tube with a nominal focal spot size of 10 μm. The digital detector uses CsI/CMOS with a pixel size of 50 × 50 μm. The phantoms used consisted of one acrylic plate, two polystyrene plates, and a habanero pepper. Tomosynthesis images were reconstructed from 51 images acquired over a ±25° arc. All phase shift images were reconstructed using the APBA.Results: Image contrast derived from the planar phase shift image of an acrylic plate of uniform thickness exceeded the contrast of the traditional attenuation image by an approximate factor of two. Comparison of the planar phase shift images from a single, uniform thickness polystyrene plate with two polystyrene plates demonstrated an approximate linearity of the estimated phase shift with plate thickness (−1600 rad vs −2970 rad). Tomographic phase shift images of the habanero pepper exhibited acceptable spatial resolution and contrast comparable to the corresponding attenuation image.Conclusions: This work demonstrated the feasibility of laboratory-based phase shift tomosynthesis and suggests that phase shift imaging could potentially provide a new imaging biomarker. Further investigation will be needed to determine if phase shift contrast will be able to provide new tissue contrast information or improved clinical performance.

  7. Effects of extended work shifts and shift work on patient safety, productivity, and employee health.

    PubMed

    Keller, Simone M

    2009-12-01

    It is estimated 1.3 million health care errors occur each year and of those errors 48,000 to 98,000 result in the deaths of patients (Barger et al., 2006). Errors occur for a variety of reasons, including the effects of extended work hours and shift work. The need for around-the-clock staff coverage has resulted in creative ways to maintain quality patient care, keep health care errors or adverse events to a minimum, and still meet the needs of the organization. One way organizations have attempted to alleviate staff shortages is to create extended work shifts. Instead of the standard 8-hour shift, workers are now working 10, 12, 16, or more hours to provide continuous patient care. Although literature does support these staffing patterns, it cannot be denied that shifts beyond the traditional 8 hours increase staff fatigue, health care errors, and adverse events and outcomes and decrease alertness and productivity. This article includes a review of current literature on shift work, the definition of shift work, error rates and adverse outcomes related to shift work, health effects on shift workers, shift work effects on older workers, recommended optimal shift length, positive and negative effects of shift work on the shift worker, hazards associated with driving after extended shifts, and implications for occupational health nurses.

  8. Socioecological regime shifts in the setting of complex social interactions

    NASA Astrophysics Data System (ADS)

    Sugiarto, Hendrik Santoso; Chung, Ning Ning; Lai, Choy Heng; Chew, Lock Yue

    2015-06-01

    The coupling between social and ecological system has become more ubiquitous and predominant in the current era. The strong interaction between these systems can bring about regime shifts which in the extreme can lead to the collapse of social cooperation and the extinction of ecological resources. In this paper, we study the occurrence of such regime shifts in the context of a coupled social-ecological system where social cooperation is established by means of sanction that punishes local selfish act and promotes norms that prescribe nonexcessive resource extraction. In particular, we investigate the role of social networks on social-ecological regimes shift and the corresponding hysteresis effects caused by the local ostracism mechanism under different social and ecological parameters. Our results show that a lowering of network degree reduces the hysteresis effect and also alters the tipping point, which is duly verified by our numerical results and analytical estimation. Interestingly, the hysteresis effect is found to be stronger in scale-free network in comparison with random network even when both networks have the same average degree. These results provide deeper insights into the resilience of these systems, and can have important implications on the management of coupled social-ecological systems with complex social interactions.

  9. 29 CFR 102.171 - Cost shifting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Cost shifting. 102.171 Section 102.171 Labor Regulations... By Federal Income Tax Refund Offset § 102.171 Cost shifting. Costs incurred by the Agency in... amount of the offset. Such costs may include administrative costs and attorneys fees....

  10. 29 CFR 102.165 - Cost shifting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Cost shifting. 102.165 Section 102.165 Labor Regulations... by Administrative Offset § 102.165 Cost shifting. Costs incurred by the Agency in connection with... offset. Such costs may include administrative costs and attorneys fees....

  11. Gain Shift Corrections at Chi-Nu

    SciTech Connect

    Brown, Tristan Brooks; Devlin, Matthew James

    2016-08-30

    Ambient conditions have the potential to cause changes in liquid scintillator detector gain that vary with time and temperature. These gain shifts can lead to poor resolution in both energy as well as pulse shape discrimination. In order to correct for these shifts in the Chi-Nu high energy array, a laser system has been developed for calibration of the pulse height signals.

  12. A simplified, compact static shift register

    NASA Technical Reports Server (NTRS)

    Pryor, R. L.; Smith, A. M.

    1972-01-01

    Shift register was developed which uses only one D type flip-flop and improves packaging density by approximately 25% over the usual arrangement. Circuit is compromise between full master-slave arrangement and dynamic shift register, with limitation only of length of time that clock can be held high during new data entry.

  13. Set Shifting Among Adolescents with Anorexia Nervosa

    PubMed Central

    Fitzpatrick, Kathleen Kara; Darcy, Alison; Colborn, Danielle; Gudorf, Caroline; Lock, James

    2012-01-01

    Objective Set shifting difficulties are documented for adults with anorexia nervosa (AN). However, AN typically onsets in adolescents and it is unclear if set-shifting difficulties are a result of chronic AN or present earlier in its course. This study examined whether adolescents with short duration AN demonstrated set shifting difficulties compared to healthy controls (HC). Method Data on set shifting collected from the Delis-Kaplan Executive Functioning System (DKEFS) and Wisconsin Card Sort Task (WCST) as well as eating psychopathology were collected from 32 adolescent inpatients with AN and compared to those from 22 HCs. Results There were no differences in set-shifting in adolescents with AN compared to HCs on most measures. Conclusion The findings suggest that set-shifting difficulties in AN may be a consequence of AN. Future studies should explore set-shifting difficulties in a larger sample of adolescents with the AN to determine if there is sub-set of adolescents with these difficulties and determine any relationship of set-shifting to the development of a chronic from of AN. PMID:22692985

  14. A Short History of Three Chemical Shifts

    ERIC Educational Resources Information Center

    Nagaoka, Shin-ichi

    2007-01-01

    A short history of chemical shifts in nuclear magnetic resonance (NMR), electron spectroscopy for chemical analysis (ESCA) and Mossbauer spectroscopy, which are useful for chemical studies, is described. The term chemical shift is shown to have originated in the mistaken assumption that nuclei of a given element would all undergo resonance at the…

  15. Lamb Shift in Nonrelativistic Quantum Electrodynamics.

    ERIC Educational Resources Information Center

    Grotch, Howard

    1981-01-01

    The bound electron self-energy or Lamb shift is calculated in nonrelativistic quantum electrodynamics. Retardation is retained and also an interaction previously dropped in other nonrelativistic approaches is kept. Results are finite without introducing a cutoff and lead to a Lamb shift in hydrogen of 1030.9 MHz. (Author/JN)

  16. Social Change and Language Shift: South Africa.

    ERIC Educational Resources Information Center

    Kamwangamalu, Nkonko M.

    2003-01-01

    Examines language shift from majority African languages, such as Sotho, Xhosa, and Zulu to English in South Africa. Examines the extent to which sociopolitical changes that have taken place in South Africa have impacted everyday linguistic interaction and have contributed to language shift from the indigenous African language to English,…

  17. Apparatus for controlling transmission gear shift selection

    SciTech Connect

    Bailey, T.M.

    1986-07-29

    In an automotive engine having an electrical power source and an automatic or semi-automatic transmission including a manually operated transmission gear shift lever having at least two forward drive positions, an apparatus is described which consists of: (a) a speed sensing means for sensing the rotation speed of the engine and generating an output signal when the engine reaches a preselected rotational speed; and (b) a gear shifting means for changing the shift positions of the gear shift lever from a first drive position to a second drive position automatically in response to the output signal from the speed sensing means, the gear shifting means including (i) a latch actuable between open and closed positions, (ii) a normally de-energized solenoid having a plunger connected to the latch and operable to move the latch to the open position when the solenoid is energized by the electrical power source, (iii) a relay means for allowing the energizing of the solenoid by the power source in response to the output signal from the speed sensing means, and (iv) an actuating means, including a spring biased linkage mechanism operably connected to the gear shift lever and the latch, for actuating the movement of the gear shift lever from the first drive position to the second drive position in response to movement of the latch from the closed to the open position, thereby causing gear shifting to occur when the engine reaches the preselected rotational speed.

  18. Quality of life in shift work syndrome.

    PubMed

    Puca, F M; Perrucci, S; Prudenzano, M P; Savarese, M; Misceo, S; Perilli, S; Palumbo, M; Libro, G; Genco, S

    1996-01-01

    Air Force radar controllers represent an excellent example of night shift workers, as they are obliged to demonstrate perfect alertness during working hours. We set out: a) to assess the quality of life in these shift workers; b) to identify those with shift work syndrome and c) to evaluate the possible effects of triazolam both on their quality of life and sleep. The results reveal an impairment of the quality of life in shift workers, independently of the presence of a circadian rhythm sleep disorder. Quality of life was more severely impaired in subjects with circadian rhythm sleep disorder. Hypnotic therapy brought about an improvement both in the sleep disorder and in the quality of life of subjects affected by shift work syndrome. Selective alertness tests failed to demonstrate any "sedative carry-over" in the treated patients.

  19. Doppler interpretation of quasar red shifts.

    PubMed

    Zapolsky, H S

    1966-08-05

    The hypothesis that the quasistellar sources (quasars) are local objects moving with velocities close to the speed of light is examined. Provided there is no observational cutoff on apparent bolometric magnitude for the quasars, the transverse Doppler effect leads to the expectation of fewer blue shifts than red shifts for an isotropic distribution of velocities. Such a distribution also yields a function N(z), the number of objects with red shift less than z which is not inconsistent with the present data. On the basis of two extreme assumptions concerning the origin of such rapidly moving sources, we computed curves of red shift plotted against magnitude. In particular, the curve obtained on the assumption that the quasars originated from an explosion in or nearby our own galaxy is in as good agreement with the observations as the curve of cosmological red shift plotted against magnitude.

  20. Design principles for shift current photovoltaics

    PubMed Central

    Cook, Ashley M.; M. Fregoso, Benjamin; de Juan, Fernando; Coh, Sinisa; Moore, Joel E.

    2017-01-01

    While the basic principles of conventional solar cells are well understood, little attention has gone towards maximizing the efficiency of photovoltaic devices based on shift currents. By analysing effective models, here we outline simple design principles for the optimization of shift currents for frequencies near the band gap. Our method allows us to express the band edge shift current in terms of a few model parameters and to show it depends explicitly on wavefunctions in addition to standard band structure. We use our approach to identify two classes of shift current photovoltaics, ferroelectric polymer films and single-layer orthorhombic monochalcogenides such as GeS, which display the largest band edge responsivities reported so far. Moreover, exploring the parameter space of the tight-binding models that describe them we find photoresponsivities that can exceed 100 mA W−1. Our results illustrate the great potential of shift current photovoltaics to compete with conventional solar cells. PMID:28120823

  1. Design principles for shift current photovoltaics

    NASA Astrophysics Data System (ADS)

    Cook, Ashley M.; M. Fregoso, Benjamin; de Juan, Fernando; Coh, Sinisa; Moore, Joel E.

    2017-01-01

    While the basic principles of conventional solar cells are well understood, little attention has gone towards maximizing the efficiency of photovoltaic devices based on shift currents. By analysing effective models, here we outline simple design principles for the optimization of shift currents for frequencies near the band gap. Our method allows us to express the band edge shift current in terms of a few model parameters and to show it depends explicitly on wavefunctions in addition to standard band structure. We use our approach to identify two classes of shift current photovoltaics, ferroelectric polymer films and single-layer orthorhombic monochalcogenides such as GeS, which display the largest band edge responsivities reported so far. Moreover, exploring the parameter space of the tight-binding models that describe them we find photoresponsivities that can exceed 100 mA W-1. Our results illustrate the great potential of shift current photovoltaics to compete with conventional solar cells.

  2. Design principles for shift current photovoltaics.

    PubMed

    Cook, Ashley M; M Fregoso, Benjamin; de Juan, Fernando; Coh, Sinisa; Moore, Joel E

    2017-01-25

    While the basic principles of conventional solar cells are well understood, little attention has gone towards maximizing the efficiency of photovoltaic devices based on shift currents. By analysing effective models, here we outline simple design principles for the optimization of shift currents for frequencies near the band gap. Our method allows us to express the band edge shift current in terms of a few model parameters and to show it depends explicitly on wavefunctions in addition to standard band structure. We use our approach to identify two classes of shift current photovoltaics, ferroelectric polymer films and single-layer orthorhombic monochalcogenides such as GeS, which display the largest band edge responsivities reported so far. Moreover, exploring the parameter space of the tight-binding models that describe them we find photoresponsivities that can exceed 100 mA W(-1). Our results illustrate the great potential of shift current photovoltaics to compete with conventional solar cells.

  3. Cloning the human SUMO1 promoter.

    PubMed

    Nanos-Webb, Angela; Deyrieux, Adeline; Bian, Xue-lin; Rosas-Acosta, Germán; Wilson, Van G

    2010-03-01

    Regulation of the sumoylation system at the level of gene expression has not yet been explored. To begin to define transcriptional regulatory features, the promoter region for the SUMO1 gene was cloned from human genomic DNA and characterized. Initially, a 532 base pair fragment upstream of and including the predicted SUMO1 transcription start site (TSS) was cloned and shown to possess promoter activity. Subsequent deletion analysis showed that a smaller fragment containing 158 bp upstream of the TSS region exhibited basal promoter activity in both human and rodent cell lines. Within this basal promoter fragment, there were predicted binding sites for numerous transcription factors, including the nude mouse gene product, Whn (FoxN1). Electrophoretic mobility shift assays showed that Whn could bind to an ACGC motif adjacent to the TSR, and in transfection studies Whn stimulated a 3-fold increase in transcription from this cloned promoter in keratinocytes (HaCaT cells). Mutation of the ACGC motif abrogated both Whn binding and transcriptional activation, indicating that the Whn effect is likely due to direct interaction with this promoter element. Consistent with these observations on the cloned promoter region, Whn also modestly stimulated transcription from the endogenous, genomic SUMO1 promoter in HaCaT cells, consistent with Whn potentially playing a regulatory role for SUMO1 transcription in keratinocytes.

  4. The double jeopardy of sales promotions.

    PubMed

    Jones, J P

    1990-01-01

    The maturing of most consumer markets in the United States has put great pressure on manufacturers in their search for growth. They have concentrated on building sales and expanding share proportions in the stagnant markets with devices like niche products, product extensions, mergers, and international ventures. They have shifted emphasis to sales promotions at the expense of advertising. But promotions, when you come right down to it, mean price reductions. Trade promotions are almost always rebates, and consumer promotions are usually temporary price reductions or coupons. The cost in reduced profit, demonstrated mathematically through calculations of price elasticity, is severe. Besides, when the promotion is over, the manufacturer has not moved forward an inch in shoring up the brand franchise. Promotions bring volatile demand, whereas the producer seeks stable demand. By sustaining a brand image and building customer loyalty, on the other hand, theme advertising can stabilize demand. Moreover, this type of advertising is less likely than promotion is to invite destructive competitive retaliation. Calculation of the advertising elasticity of a brand indicates that sometimes even modest sales increases can produce healthy profit improvement. In a well-planned marketing campaign, there is often good reason to include trade or consumer promotion--to counter a leading competitor's moves, for example. But there is no point in carrying out wild swings at rivals in a struggle for market share. Mathematical techniques can aid the efficiency of marketing planning and put on a more rational basis the decision on where to put the dollars.

  5. Social norms shift behavioral and neural responses to foods.

    PubMed

    Nook, Erik C; Zaki, Jamil

    2015-07-01

    Obesity contributes to 2.8 million deaths annually, making interventions to promote healthy eating critical. Although preliminary research suggests that social norms influence eating behavior, the underlying psychological and neural mechanisms of such conformity remain unexplored. We used fMRI to investigate whether group norms shift individuals' preferences for foods at both behavioral and neural levels. Hungry participants rated how much they wanted to eat a series of healthy and unhealthy foods and, after each trial, saw ratings that ostensibly represented their peers' preferences. This feedback was manipulated such that peers appeared to prefer each food more than, less than, or as much as participants themselves. After a delay, participants rerated each food. Participants' second ratings shifted to resemble group norms. Initial consensus, as compared to disagreement, with peers produced activity in the nucleus accumbens, a region associated with reward prediction errors. Furthermore, the strength of this activity predicted the extent to which participants' ratings conformed to peer ratings, suggesting that the value associated with consensus drives social influence. Ventromedial prefrontal cortex (vMPFC), a region associated with value computation, initially responded more strongly to unhealthy, as compared to healthy, foods. However, this effect was "overwritten" by group norms. After individuals learned their peers' preferences, vMPFC responses tracked the popularity, but not the healthfulness, of foods. Furthermore, changes in vMPFC activity tracked social influence over behavioral ratings. These data provide evidence that group norms can shift food preferences, supporting the use of norms-based interventions to promote healthy eating.

  6. Equations for Bistatic Doppler Shift and Rate of Change of Doppler Shift of Dark Satellite Observations

    DTIC Science & Technology

    Equations are given for the doppler shift and rate of change of doppler shift for the bistatic case where an orbiting, nontransmitting earth... of change of doppler shift, satellite height, earth-center angle between the receiver and the satellite, and zenith angle from receiver to satellite are shown for a typical satellite, 1958 Alpha, Explorer I....have been computed, using transmitting and receiving sites of the Space Surveillance System. Plots of various relationships between doppler shift, rate

  7. New Teachers' Identity Shifts at the Boundary of Teacher Education and Initial Practice

    ERIC Educational Resources Information Center

    Beauchamp, Catherine; Thomas, Lynn

    2011-01-01

    As teachers enter the school communities of their initial practice, they experience identity shifts that reflect their learning. Throughout teacher education they have constructed an identity informed by their previous school experiences, the ideas and approaches promoted by their teacher education programs, and an ideal of the teachers they hope…

  8. Dual-wavelength in-line phase-shifting interferometry based on two dc-term-suppressed intensities with a special phase shift for quantitative phase extraction.

    PubMed

    Xu, Xiaoqing; Wang, Yawei; Xu, Yuanyuan; Jin, Weifeng

    2016-06-01

    To efficiently promote the phase retrieval in quantitative phase imaging, a new approach of quantitative phase extraction is proposed based on two intensities with dual wavelength after filtering the corresponding dc terms for each wavelength, in which a special phase shift is used. In this approach, only the combination of the phase-shifting technique and subtraction procedures is needed, and no additional algorithms are required. The thickness of the phase object can be achieved from the phase image, which is related to the synthetic beat wavelength. The feasibility of this method is verified by the simulated experiments of the optically transparent objects.

  9. Making value a priority: how this paradigm shift is changing the landscape in health care.

    PubMed

    Kimberly, John; Cronk, Imran

    2016-10-01

    The world of health care is changing dramatically, as reflected in the number, magnitude, and scope of innovative new approaches-to how illness is treated and how better health is promoted-that are being implemented around the globe. The changes triggered by these initiatives affect both how care is organized, managed, and paid for and the kinds of approaches that are being developed to keep people healthy. Underlying these changes is a more fundamental paradigm shift, a shift in the priority given to "value" in the formulation of policy and management practice. This brief essay highlights five trends that are central in this shift: increasing emphasis on health promotion, movement toward value-based payment, advances in digital/mobile technology, exploitation of big data, and changes in support for biomedical research. Each of these has its own value controversies, and the individual impact of each is impossible to predict. Collectively, however, their impact is likely to be significant.

  10. Mechanized pivot shift test achieves greater accuracy than manual pivot shift test.

    PubMed

    Musahl, Volker; Voos, James; O'Loughlin, Padhraig F; Stueber, Volker; Kendoff, Daniel; Pearle, Andrew D

    2010-09-01

    The objective of this study was to design a navigated mechanized pivot shift test setup and evaluate its repeatability in the ACL-deficient knee. It was hypothesized that translations and rotations measured with the mechanized pivot shift would be more repeatable when compared to those obtained with a manual pivot shift. Twelve fresh frozen cadaveric hip-to-toe whole lower extremities were used for this study. A manual pivot shift test was performed in the intact knee and in the ACL-deficient knee and was repeated three times. A navigation system simultaneously recorded tibial translation and rotation. The mechanized pivot shift test consists of a modified continuous passive motion (CPM) machine and a custom-made foot holder to allow for the application of internal rotation moments at the knee. Valgus moments were achieved by a 45 degrees tilt of the CPM machine with respect to the supine position and a Velcro strap secured across the proximal tibia. The mechanized pivot shift was repeated three times. Repeated measures ANOVA was used to compare manual and mechanized pivot shift testing. An intra-class correlation coefficient (ICC) was used to determine variability within each knee at each testing condition. In the ACL-deficient knee, translation with manual pivot shift testing (11.7 +/- 2.6 mm) was significantly higher than with mechanized pivot shift testing (7.4 +/- 2.5 mm; p < 0.05). Rotation with the manual pivot shift testing (18.6 +/- 5.4 degrees) was also significantly higher than with mechanized pivot shift testing (11.0 +/- 2.3 degrees; p < 0.05). The intra-class ICC for translations was 0.76 for manual pivot shift and 0.92 for the mechanized pivot shift test. The intra-class ICC for rotations was 0.89 for manual pivot shift and 0.82 for the mechanized pivot shift test. This study introduced a modified CPM for mechanized pivot shift testing. Although recorded translations and rotations with the mechanized pivot shift test were lower than with manual

  11. Optical vortex phase-shifting digital holography.

    PubMed

    Guo, Cheng-Shan; Cheng, Xin; Ren, Xiu-Yun; Ding, Jian-Ping; Wang, Hui-Tian

    2004-10-18

    We report a new optical vortex phase-shifting method for digital holography, in which an optical vortex mode is taken as the reference beam for holographic recording, and the required phase shifts are directly generated by rotating the vortex mode. In digital reconstruction, the complex amplitude of the object wave can be retrieved by use of the conventional phase shifting algorithm on condition that the digital illumination beam is replaced by an vortex beam with the same topological charge as the reference used. Both the theoretical analysis and experimental results demonstrate the feasibility of this approach.

  12. Theory of the Helium Isotope Shift

    SciTech Connect

    Pachucki, Krzysztof; Yerokhin, V. A.

    2015-09-15

    Theory of the isotope shift of the centroid energies of light few-electron atoms is reviewed. Numerical results are presented for the isotope shift of the 2{sup 3}P-2{sup 3}S and 2{sup 1}S-2{sup 3}S transition energies of {sup 3}He and {sup 4}He. By comparing theoretical predictions for the isotope shift with the experimental results, the difference of the squares of the nuclear charge radii of {sup 3}He and {sup 4}He, δR{sup 2}, is determined with high accuracy.

  13. Search for Higgs shifts in white dwarfs

    SciTech Connect

    Onofrio, Roberto; Wegner, Gary A. E-mail: gary.a.wegner@dartmouth.edu

    2014-08-20

    We report on a search for differential shifts between electronic and vibronic transitions in carbon-rich white dwarfs BPM 27606 and Procyon B. The absence of differential shifts within the spectral resolution and taking into account systematic effects such as space motion and pressure shifts allows us to set the first upper bound of astrophysical origin on the coupling between the Higgs field and the Kreschmann curvature invariant. Our analysis provides the basis for a more general methodology to derive bounds to the coupling of long-range scalar fields to curvature invariants in an astrophysical setting complementary to the ones available from high-energy physics or table-top experiments.

  14. Giant lamb shift in photonic crystals.

    PubMed

    Wang, Xue-Hua; Kivshar, Yuri S; Gu, Ben-Yuan

    2004-08-13

    We obtain a general result for the Lamb shift of excited states of multilevel atoms in inhomogeneous electromagnetic structures and apply it to study atomic hydrogen in inverse-opal photonic crystals. We find that the photonic-crystal environment can lead to very large values of the Lamb shift, as compared to the case of vacuum. We also suggest that the position-dependent Lamb shift should extend from a single level to a miniband for an assembly of atoms with random distribution in space, similar to the velocity-dependent Doppler effect in atomic/molecular gases.

  15. Adaptation to shift work: physiologically based modeling of the effects of lighting and shifts' start time.

    PubMed

    Postnova, Svetlana; Robinson, Peter A; Postnov, Dmitry D

    2013-01-01

    Shift work has become an integral part of our life with almost 20% of the population being involved in different shift schedules in developed countries. However, the atypical work times, especially the night shifts, are associated with reduced quality and quantity of sleep that leads to increase of sleepiness often culminating in accidents. It has been demonstrated that shift workers' sleepiness can be improved by a proper scheduling of light exposure and optimizing shifts timing. Here, an integrated physiologically-based model of sleep-wake cycles is used to predict adaptation to shift work in different light conditions and for different shift start times for a schedule of four consecutive days of work. The integrated model combines a model of the ascending arousal system in the brain that controls the sleep-wake switch and a human circadian pacemaker model. To validate the application of the integrated model and demonstrate its utility, its dynamics are adjusted to achieve a fit to published experimental results showing adaptation of night shift workers (n = 8) in conditions of either bright or regular lighting. Further, the model is used to predict the shift workers' adaptation to the same shift schedule, but for conditions not considered in the experiment. The model demonstrates that the intensity of shift light can be reduced fourfold from that used in the experiment and still produce good adaptation to night work. The model predicts that sleepiness of the workers during night shifts on a protocol with either bright or regular lighting can be significantly improved by starting the shift earlier in the night, e.g.; at 21:00 instead of 00:00. Finally, the study predicts that people of the same chronotype, i.e. with identical sleep times in normal conditions, can have drastically different responses to shift work depending on their intrinsic circadian and homeostatic parameters.

  16. Postural Stability is Altered by Blood Shift

    NASA Astrophysics Data System (ADS)

    Marais, M.; Denise, P.; Guincetre, J. Y.; Normand, H.

    2008-06-01

    Non-vestibular influences as shift in blood volume changed perception of body posture. Then, factors affecting blood shift may alter postural control. The purpose of our study was to investigate the effects of leg venous contention on postural stability. Twelve subjects were studied on a balance plate for 5 minutes with the eyes closed, in 3 conditions: with no leg venous contention or grade 1 and 3 support stockings. Standard deviation of x and y position was calculated before and after the closure of the eyes. Strong venous contention altered postural stability, after the eyes were closed, during the first 10 s of standing. As support stockings prevent blood shift induced by upright posture, this result is in line with the hypothesis that blood shifts influence the perception of body orientation and postural control among others factors as vision, vestibular inputs... This strong venous contention could induce an increase of fall.

  17. Red Shifts with Obliquely Approaching Light Sources.

    ERIC Educational Resources Information Center

    Head, C. E.; Moore-Head, M. E.

    1988-01-01

    Refutes the Doppler effect as the explanation of large red shifts in the spectra of distant galaxies and explains the relativistic effects in which the light sources approach the observer obliquely. Provides several diagrams and graphs. (YP)

  18. Data for phase angle shift with frequency

    PubMed Central

    Paul, T.; Banerjee, D.; Kargupta, K.

    2016-01-01

    Phase angle shift between the current and voltage with frequency has been reported for a single phosphoric acid fuel cell in the cell temperature from 100 °C to 160 °C and the humidifier temperature from 40 °C to 90 °C. An electrochemical workbench is employed to find the shift. The figure of phase angle shift shows a peak in high humidifier temperatures. The peak in phase angle shift directs to lower frequency side with decreasing humidifier temperature. The estimation of electrochemical reaction time is also evaluated in the humidifier temperature zone from 50 °C to 90 °C. PMID:27158655

  19. Trends in adsorbate induced core level shifts

    NASA Astrophysics Data System (ADS)

    Nilsson, Viktor; Van den Bossche, Maxime; Hellman, Anders; Grönbeck, Henrik

    2015-10-01

    Photoelectron core level spectroscopy is commonly used to monitor atomic and molecular adsorption on metal surfaces. As changes in the electron binding energies are convoluted measures with different origins, calculations are often used to facilitate the decoding of experimental signatures. The interpretation could in this sense benefit from knowledge on trends in surface core level shifts for different metals and adsorbates. Here, density functional theory calculations have been used to systematically evaluate core level shifts for (111) and (100) surfaces of 3d, 4d, and 5d transition metals upon CO, H, O and S adsorption. The results reveal trends and several non-intuitive cases. Moreover, the difficulties correlating core level shifts with charging and d-band shifts are underlined.

  20. Gradual regime shifts in fairy circles.

    PubMed

    Zelnik, Yuval R; Meron, Ehud; Bel, Golan

    2015-10-06

    Large responses of ecosystems to small changes in the conditions--regime shifts--are of great interest and importance. In spatially extended ecosystems, these shifts may be local or global. Using empirical data and mathematical modeling, we investigated the dynamics of the Namibian fairy circle ecosystem as a case study of regime shifts in a pattern-forming ecosystem. Our results provide new support, based on the dynamics of the ecosystem, for the view of fairy circles as a self-organization phenomenon driven by water-vegetation interactions. The study further suggests that fairy circle birth and death processes correspond to spatially confined transitions between alternative stable states. Cascades of such transitions, possible in various pattern-forming systems, result in gradual rather than abrupt regime shifts.

  1. Prolonged instability prior to a regime shift.

    PubMed

    Spanbauer, Trisha L; Allen, Craig R; Angeler, David G; Eason, Tarsha; Fritz, Sherilyn C; Garmestani, Ahjond S; Nash, Kirsty L; Stone, Jeffery R

    2014-01-01

    Regime shifts are generally defined as the point of 'abrupt' change in the state of a system. However, a seemingly abrupt transition can be the product of a system reorganization that has been ongoing much longer than is evident in statistical analysis of a single component of the system. Using both univariate and multivariate statistical methods, we tested a long-term high-resolution paleoecological dataset with a known change in species assemblage for a regime shift. Analysis of this dataset with Fisher Information and multivariate time series modeling showed that there was a∼2000 year period of instability prior to the regime shift. This period of instability and the subsequent regime shift coincide with regional climate change, indicating that the system is undergoing extrinsic forcing. Paleoecological records offer a unique opportunity to test tools for the detection of thresholds and stable-states, and thus to examine the long-term stability of ecosystems over periods of multiple millennia.

  2. Phylogenetic test of speciation by host shift in leaf cone moths (Caloptilia) feeding on maples (Acer).

    PubMed

    Nakadai, Ryosuke; Kawakita, Atsushi

    2016-07-01

    The traditional explanation for the exceptional diversity of herbivorous insects emphasizes host shift as the major driver of speciation. However, phylogenetic studies have often demonstrated widespread host plant conservatism by insect herbivores, calling into question the prevalence of speciation by host shift to distantly related plants. A limitation of previous phylogenetic studies is that host plants were defined at the family or genus level; thus, it was unclear whether host shifts predominate at a finer taxonomic scale. The lack of a statistical approach to test the hypothesis of host-shift-driven speciation also hindered studies at the species level. Here, we analyze the radiation of leaf cone moths (Caloptilia) associated with maples (Acer) using a newly developed, phylogeny-based method that tests the role of host shift in speciation. This method has the advantage of not requiring complete taxon sampling from an entire radiation. Based on 254 host plant records for 14 Caloptilia species collected at 73 sites in Japan, we show that major dietary changes are more concentrated toward the root of the phylogeny, with host shift playing a minor role in recent speciation. We suggest that there may be other roles for host shift in promoting herbivorous insect diversification rather than facilitating speciation per se.

  3. [Sleep disorders among physicians on shift work].

    PubMed

    Schlafer, O; Wenzel, V; Högl, B

    2014-11-01

    Sleep disorders in physicians who perform shift work can result in increased risks of health problems that negatively impact performance and patient safety. Even those who cope well with shift work are likely to suffer from sleep disorders. The aim of this manuscript is to discuss possible causes, contributing factors and consequences of sleep disorders in physicians and to identify measures that can improve adaptation to shift work and treatment strategies for shift work-associated sleep disorders. The risk factors that influence the development of sleep disorders in physicians are numerous and include genetic factors (15 % of the population), age (> 50 years), undiagnosed sleep apnea,, alcohol abuse as well as multiple stress factors inherent in clinical duties (including shift work), research, teaching and family obligations. Several studies have reported an increased risk for medical errors in sleep-deprived physicians. Shift workers have an increased risk for psychiatric and cardiovascular diseases and shift work may also be a contributing factor to cancer. A relationship has been reported not only with sleep deprivation and changes in food intake but also with diabetes mellitus, obesity, hypertension and coronary heart disease. Nicotine and alcohol consumption are more frequent among shift workers. Increased sickness and accident rates among physicians when commuting (especially after night shifts) have a socioeconomic impact. In order to reduce fatigue and to improve performance, short naps during shiftwork or naps plus caffeine, have been proposed as coping strategies; however, napping during adverse circadian phases is less effective, if not impossible when unable to fall asleep. Bright and blue light supports alertness during a night shift. After shiftwork, direct sunlight exposure to the retina can be avoided by using dark sunglasses or glasses with orange lenses for commuting home. The home environment for daytime sleeping after a night shift should be

  4. South Asia's health promotion kaleidoscope.

    PubMed

    Mukhopadhyay, Alok

    2007-01-01

    South Asia has 22 percent of the world's population but only 1.3 percent of the global income. Consequently 40 percent of the population is living in absolute poverty. However the health transition in some of its countries including India and Sri Lanka is a testimony to the fact that there are proven solutions to the problems of health and development within the region. The countries of the region have much in common, including a democratic political system, four major religions, a vibrant and living tradition of voluntarism and an extensive health infrastructure which is operating well below par. Despite the underlying unity, South Asia enjoys enormous cultural, linguistic and ethnic diversity. In this large, complex and vibrant region, health promotion is a challenging task, but it also holds the key to a dramatic change in the global health situation. Many of these solutions lie in wider areas of socio-political action. There are much needed shifts in the health promotion and development efforts, particularly in the area of poverty and social justice; gender inequity; population stabilisation; health and environment; control of communicable and non-communicable diseases; and urban health strategies. The principle of cooperation, partnership and intersectoral collaboration for health will be explored. Developing an appropriate, sustainable and people centred health and development strategy in the coming decades is an enormous challenge. There has been an attempt to focus on the emerging needs of the region, which call for health promotion, and involvement of civil society, private sector and the governments bestowed with the increased responsibility of ensuring health security for people. Strengthening the existing health systems, allocating adequate resources for health development and ensuring community participation are all prerequisites to the success of health promotion in the region.

  5. Phase shifts extraction based on time-domain orthogonal character of phase-shifting interferograms

    NASA Astrophysics Data System (ADS)

    Shou, Junwei; Zhong, Liyun; Zhou, Yunfei; Tian, Jindong; Lu, Xiaoxu

    2017-01-01

    Based on the time-domain orthogonal character of different pixel intensity variation of phase-shifting interferograms, a novel non-iterative algorithm is proposed to achieve the phase shifts in random phase-shifting interferometry. Due to there is no requirement for the fringe number of phase-shifting interferograms, the proposed algorithm can work well even in the case that the fringe number of interferogram is less than one, which is a difficult problem in interferometry. Moreover, only two one-dimensional vectors, achieved from the average intensity of several pixels of interferogram, are enough to perform the phase shifts extraction, the proposed algorithm reveals rapid processing speed. Specially, compared with the conventional phase shifts extraction algorithms, the proposed algorithm does not need to perform the pixel-pixel calculation or the iterative calculation, so its processing speed is greatly improved. Both the simulation and the experiment demonstrate the outstanding performance of the proposed algorithm.

  6. Increasing the Chemical‐Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent

    PubMed Central

    Göbl, Christoph; Resch, Moritz; Strickland, Madeleine; Hartlmüller, Christoph; Viertler, Martin

    2016-01-01

    Abstract The study of intrinsically disordered proteins (IDPs) by NMR often suffers from highly overlapped resonances that prevent unambiguous chemical‐shift assignments, and data analysis that relies on well‐separated resonances. We present a covalent paramagnetic lanthanide‐binding tag (LBT) for increasing the chemical‐shift dispersion and facilitating the chemical‐shift assignment of challenging, repeat‐containing IDPs. Linkage of the DOTA‐based LBT to a cysteine residue induces pseudo‐contact shifts (PCS) for resonances more than 20 residues from the spin‐labeling site. This leads to increased chemical‐shift dispersion and decreased signal overlap, thereby greatly facilitating chemical‐shift assignment. This approach is applicable to IDPs of varying sizes and complexity, and is particularly helpful for repeat‐containing IDPs and low‐complexity regions. This results in improved efficiency for IDP analysis and binding studies. PMID:27763708

  7. A holistic view of marine regime shifts

    PubMed Central

    Conversi, Alessandra; Dakos, Vasilis; Gårdmark, Anna; Ling, Scott; Folke, Carl; Mumby, Peter J.; Greene, Charles; Edwards, Martin; Blenckner, Thorsten; Casini, Michele; Pershing, Andrew; Möllmann, Christian

    2015-01-01

    Understanding marine regime shifts is important not only for ecology but also for developing marine management that assures the provision of ecosystem services to humanity. While regime shift theory is well developed, there is still no common understanding on drivers, mechanisms and characteristic of abrupt changes in real marine ecosystems. Based on contributions to the present theme issue, we highlight some general issues that need to be overcome for developing a more comprehensive understanding of marine ecosystem regime shifts. We find a great divide between benthic reef and pelagic ocean systems in how regime shift theory is linked to observed abrupt changes. Furthermore, we suggest that the long-lasting discussion on the prevalence of top-down trophic or bottom-up physical drivers in inducing regime shifts may be overcome by taking into consideration the synergistic interactions of multiple stressors, and the special characteristics of different ecosystem types. We present a framework for the holistic investigation of marine regime shifts that considers multiple exogenous drivers that interact with endogenous mechanisms to cause abrupt, catastrophic change. This framework takes into account the time-delayed synergies of these stressors, which erode the resilience of the ecosystem and eventually enable the crossing of ecological thresholds. Finally, considering that increased pressures in the marine environment are predicted by the current climate change assessments, in order to avoid major losses of ecosystem services, we suggest that marine management approaches should incorporate knowledge on environmental thresholds and develop tools that consider regime shift dynamics and characteristics. This grand challenge can only be achieved through a holistic view of marine ecosystem dynamics as evidenced by this theme issue.

  8. Novel Synthetic Promoters from the Cestrum Yellow Leaf Curling Virus.

    PubMed

    Sahoo, Dipak Kumar; Sarkar, Shayan; Maiti, Indu B; Dey, Nrisingha

    2016-01-01

    Constitutive promoters direct gene expression uniformly in most tissues and cells at all stages of plant growth and development; they confer steady levels of transgene expression in plant cells and hence their demand is high in plant biology. The gene silencing due to promoter homology can be avoided by either using diverse promoters isolated from different plant and viral genomes or by designing synthetic promoters. The aim of this chapter was to describe the basic protocols needed to develop and analyze novel, synthetic, nearly constitutive promoters from Cestrum yellow leaf curling virus (CmYLCV) through promoter/leader deletion and activating cis-sequence analysis. We also describe the methods to evaluate the strength of the promoters efficiently in various transient expression systems like agroinfiltration assay, gene-gun method, and assay in tobacco protoplasts. Besides, the detailed methods for developing transgenic plants (tobacco and Arabidopsis) for evaluation of the promoter using the GUS reporter gene are also described. The detailed procedure for electrophoretic mobility shift assay (EMSA) coupled with super-shift EMSA analysis are also described for showing the binding of tobacco transcription factor, TGA1a to cis-elements in the CmYLCV distal promoter region.

  9. Hash: a Program to Accurately Predict Protein Hα Shifts from Neighboring Backbone Shifts3

    PubMed Central

    Zeng, Jianyang; Zhou, Pei; Donald, Bruce Randall

    2012-01-01

    Chemical shifts provide not only peak identities for analyzing NMR data, but also an important source of conformational information for studying protein structures. Current structural studies requiring Hα chemical shifts suffer from the following limitations. (1) For large proteins, the Hα chemical shifts can be difficult to assign using conventional NMR triple-resonance experiments, mainly due to the fast transverse relaxation rate of Cα that restricts the signal sensitivity. (2) Previous chemical shift prediction approaches either require homologous models with high sequence similarity or rely heavily on accurate backbone and side-chain structural coordinates. When neither sequence homologues nor structural coordinates are available, we must resort to other information to predict Hα chemical shifts. Predicting accurate Hα chemical shifts using other obtainable information, such as the chemical shifts of nearby backbone atoms (i.e., adjacent atoms in the sequence), can remedy the above dilemmas, and hence advance NMR-based structural studies of proteins. By specifically exploiting the dependencies on chemical shifts of nearby backbone atoms, we propose a novel machine learning algorithm, called Hash, to predict Hα chemical shifts. Hash combines a new fragment-based chemical shift search approach with a non-parametric regression model, called the generalized additive model, to effectively solve the prediction problem. We demonstrate that the chemical shifts of nearby backbone atoms provide a reliable source of information for predicting accurate Hα chemical shifts. Our testing results on different possible combinations of input data indicate that Hash has a wide rage of potential NMR applications in structural and biological studies of proteins. PMID:23242797

  10. Influences on Dietary Choices during Day versus Night Shift in Shift Workers: A Mixed Methods Study.

    PubMed

    Bonnell, Emily K; Huggins, Catherine E; Huggins, Chris T; McCaffrey, Tracy A; Palermo, Claire; Bonham, Maxine P

    2017-02-26

    Shift work is associated with diet-related chronic conditions such as obesity and cardiovascular disease. This study aimed to explore factors influencing food choice and dietary intake in shift workers. A fixed mixed method study design was undertaken on a convenience sample of firefighters who continually work a rotating roster. Six focus groups (n = 41) were conducted to establish factors affecting dietary intake whilst at work. Dietary intake was assessed using repeated 24 h dietary recalls (n = 19). Interviews were audio recorded, transcribed verbatim, and interpreted using thematic analysis. Dietary data were entered into FoodWorks and analysed using Wilcoxon signed-rank test; p < 0.05 was considered significant. Thematic analysis highlighted four key themes influencing dietary intake: shift schedule; attitudes and decisions of co-workers; time and accessibility; and knowledge of the relationship between food and health. Participants reported consuming more discretionary foods and limited availability of healthy food choices on night shift. Energy intakes (kJ/day) did not differ between days that included a day or night shift but greater energy density (EDenergy, kJ/g/day) of the diet was observed on night shift compared with day shift. This study has identified a number of dietary-specific shift-related factors that may contribute to an increase in unhealthy behaviours in a shift-working population. Given the increased risk of developing chronic diseases, organisational change to support workers in this environment is warranted.

  11. Influences on Dietary Choices during Day versus Night Shift in Shift Workers: A Mixed Methods Study

    PubMed Central

    Bonnell, Emily K.; Huggins, Catherine E.; Huggins, Chris T.; McCaffrey, Tracy A.; Palermo, Claire; Bonham, Maxine P.

    2017-01-01

    Shift work is associated with diet-related chronic conditions such as obesity and cardiovascular disease. This study aimed to explore factors influencing food choice and dietary intake in shift workers. A fixed mixed method study design was undertaken on a convenience sample of firefighters who continually work a rotating roster. Six focus groups (n = 41) were conducted to establish factors affecting dietary intake whilst at work. Dietary intake was assessed using repeated 24 h dietary recalls (n = 19). Interviews were audio recorded, transcribed verbatim, and interpreted using thematic analysis. Dietary data were entered into FoodWorks and analysed using Wilcoxon signed-rank test; p < 0.05 was considered significant. Thematic analysis highlighted four key themes influencing dietary intake: shift schedule; attitudes and decisions of co-workers; time and accessibility; and knowledge of the relationship between food and health. Participants reported consuming more discretionary foods and limited availability of healthy food choices on night shift. Energy intakes (kJ/day) did not differ between days that included a day or night shift but greater energy density (EDenergy, kJ/g/day) of the diet was observed on night shift compared with day shift. This study has identified a number of dietary-specific shift-related factors that may contribute to an increase in unhealthy behaviours in a shift-working population. Given the increased risk of developing chronic diseases, organisational change to support workers in this environment is warranted. PMID:28245625

  12. Phase shifting interferometry from two normalized interferograms with random tilt phase-shift.

    PubMed

    Liu, Fengwei; Wu, Yongqian; Wu, Fan

    2015-07-27

    We propose a novel phase shifting interferometry from two normalized interferograms with random tilt phase-shift. The determination of tilt phase-shift is performed by extracting the tilted phase-shift plane from the phase difference of two normalized interferograms, and with the calculated tilt phase-shift value the phase distribution can be retrieved from the two normalized frames. By analyzing the distribution of phase difference and utilizing special points fitting method, the tilted phase-shift plane is extracted in three different cases, which relate to different magnitudes of tilts. Proposed method has been applied to simulations and experiments successfully and the satisfactory results manifest that proposed method is of high accuracy and high speed compared with the three step iterative method. Additionally, both open and closed fringe can be analyzed with proposed method. What's more, it cannot only eliminate the small tilt-shift error caused by slight vibration in phase-shifting interferometry, but also detect the large tilt phase-shift in phase-tilting interferometry. Thus, it will relaxes the requirements on the accuracy of phase shifter, and the costly phase shifter may even be useless by applying proposed method in high amplitude vibrated circumstance to achieve high-precision analysis.

  13. Nozzle Aerodynamic Stability During a Throat Shift

    NASA Technical Reports Server (NTRS)

    Kawecki, Edwin J.; Ribeiro, Gregg L.

    2005-01-01

    An experimental investigation was conducted on the internal aerodynamic stability of a family of two-dimensional (2-D) High Speed Civil Transport (HSCT) nozzle concepts. These nozzles function during takeoff as mixer-ejectors to meet acoustic requirements, and then convert to conventional high-performance convergent-divergent (CD) nozzles at cruise. The transition between takeoff mode and cruise mode results in the aerodynamic throat and the minimum cross-sectional area that controls the engine backpressure shifting location within the nozzle. The stability and steadiness of the nozzle aerodynamics during this so called throat shift process can directly affect the engine aerodynamic stability, and the mechanical design of the nozzle. The objective of the study was to determine if pressure spikes or other perturbations occurred during the throat shift process and, if so, identify the caused mechanisms for the perturbations. The two nozzle concepts modeled in the test program were the fixed chute (FC) and downstream mixer (DSM). These 2-D nozzles differ principally in that the FC has a large over-area between the forward throat and aft throat locations, while the DSM has an over-area of only about 10 percent. The conclusions were that engine mass flow and backpressure can be held constant simultaneously during nozzle throat shifts on this class of nozzles, and mode shifts can be accomplished at a constant mass flow and engine backpressure without upstream pressure perturbations.

  14. Chemical shift prediction for denatured proteins.

    PubMed

    Prestegard, James H; Sahu, Sarata C; Nkari, Wendy K; Morris, Laura C; Live, David; Gruta, Christian

    2013-02-01

    While chemical shift prediction has played an important role in aspects of protein NMR that include identification of secondary structure, generation of torsion angle constraints for structure determination, and assignment of resonances in spectra of intrinsically disordered proteins, interest has arisen more recently in using it in alternate assignment strategies for crosspeaks in (1)H-(15)N HSQC spectra of sparsely labeled proteins. One such approach involves correlation of crosspeaks in the spectrum of the native protein with those observed in the spectrum of the denatured protein, followed by assignment of the peaks in the latter spectrum. As in the case of disordered proteins, predicted chemical shifts can aid in these assignments. Some previously developed empirical formulas for chemical shift prediction have depended on basis data sets of 20 pentapeptides. In each case the central residue was varied among the 20 amino common acids, with the flanking residues held constant throughout the given series. However, previous choices of solvent conditions and flanking residues make the parameters in these formulas less than ideal for general application to denatured proteins. Here, we report (1)H and (15)N shifts for a set of alanine based pentapeptides under the low pH urea denaturing conditions that are more appropriate for sparse label assignments. New parameters have been derived and a Perl script was created to facilitate comparison with other parameter sets. A small, but significant, improvement in shift predictions for denatured ubiquitin is demonstrated.

  15. Attentional Set-Shifting Across Species.

    PubMed

    Brown, Verity J; Tait, David S

    Attentional set-shifting, as a measure of executive flexibility, has been a staple of investigations into human cognition for over six decades. Mediated by the frontal cortex in mammals, the cognitive processes involved in forming, maintaining and shifting an attentional set are vulnerable to dysfunction arising from a number of human neurodegenerative diseases (such as Alzheimer's, Parkinson's and Huntington's diseases) and other neurological disorders (such as schizophrenia, depression, and attention deficit/hyperactivity disorder). Our understanding of these diseases and disorders, and the cognitive impairments induced by them, continues to advance, in tandem with an increasing number of tools at our disposal. In this chapter, we review and compare commonly used attentional set-shifting tasks (the Wisconsin Card Sorting Task and Intradimensional/Extradimensional tasks) and their applicability across species. In addition to humans, attentional set-shifting has been observed in a number of other animals, with a substantial body of literature describing performance in monkeys and rodents. We consider the task designs used to investigate attentional set-shifting in these species and the methods used to model human diseases and disorders, and ultimately the comparisons and differences between species-specific tasks, and between performance across species.

  16. Choice Shift in Opinion Network Dynamics

    NASA Astrophysics Data System (ADS)

    Gabbay, Michael

    Choice shift is a phenomenon associated with small group dynamics whereby group discussion causes group members to shift their opinions in a more extreme direction so that the mean post-discussion opinion exceeds the mean pre-discussion opinion. Also known as group polarization, choice shift is a robust experimental phenomenon and has been well-studied within social psychology. In opinion network models, shifts toward extremism are typically produced by the presence of stubborn agents at the extremes of the opinion axis, whose opinions are much more resistant to change than moderate agents. However, we present a model in which choice shift can arise without the assumption of stubborn agents; the model evolves member opinions and uncertainties using coupled nonlinear differential equations. In addition, we briefly describe the results of a recent experiment conducted involving online group discussion concerning the outcome of National Football League games are described. The model predictions concerning the effects of network structure, disagreement level, and team choice (favorite or underdog) are in accord with the experimental results. This research was funded by the Office of Naval Research and the Defense Threat Reduction Agency.

  17. How automatic is manual gear shifting?

    PubMed

    Shinar, D; Meir, M; Ben-Shoham, I

    1998-12-01

    Manual gear shifting is often used as an example of an automated (vs. controlled) process in driving. The present study provided an empirical evaluation of this assumption by evaluating sign detection and recall performance of novice and experienced drivers driving manual shift and automatic transmission cars in a downtown area requiring frequent gear shifting. The results showed that manual gear shifting significantly impaired sign detection performance of novice drivers using manual gears compared with novice drivers using an automatic transmission, whereas no such differences existed between the two transmission types for experienced drivers. The results clearly demonstrate that manual gear shifting is a complex psychomotor skill that is not easily (or quickly) automated and that until it becomes automated, it is an attention-demanding task that may impair other monitoring aspects of driving performance. Actual or potential applications of this research include a reevaluation of the learning process in driving and the need for phased instruction in driving from automatic gears to manual gears.

  18. [Shifting path of industrial pollution gravity centers and its driving mechanism in Pan-Yangtze River Delta].

    PubMed

    Zhao, Hai-Xia; Jiang, Xiao-Wei; Cui, Jian-Xin

    2014-11-01

    Shifting path of industrial pollution gravity centers is the response of environmental special formation during the industry transfer process, in order to prove the responding of industrial pollution gravity centers to industry transfer in economically developed areas, this paper calculates the gravity centers of industrial wastewater, gas and solid patterns and reveals the shifting path and its driving mechanism, using the data of industrial pollution in the Pan-Yangtze River Delta from 2000 to 2010. The results show that the gravity center of the industrial waste in Pan-Yangtze River Delta shifts for sure in the last 10 years, and gravity center of solid waste shifts the maximum distance within the three wastes, which was 180.18 km, and shifting distances for waste gas and waste water were 109.51 km and 85.92 km respectively. Moreover, the gravity center of the industrial waste in Pan-Yangtze River Delta shifts westwards, and gravity centers of waste water, gas and solid shift for 0.40 degrees, 0.17 degrees and 0.03 degrees respectively. The shifting of industrial pollution gravity centers is driven by many factors. The rapid development of the heavy industry in Anhui and Jiangxi provinces results in the westward shifting of the pollutions. The optimization and adjustment of industrial structures in Yangtze River Delta region benefit to alleviating industrial pollution, and high-polluting industries shifted to Anhui and Jiangxi provinces promotes pollution gravity center shifting to west. While the development of massive clean enterprise, strong environmental management efforts and better environmental monitoring system slow the shifting trend of industrial pollution to the east in Yangtze River Delta. The study of industrial pollution gravity shift and its driving mechanism provides a new angle of view to analyze the relationship between economic development and environmental pollution, and also provides academic basis for synthetical management and control of

  19. Developing a Promotional Video

    ERIC Educational Resources Information Center

    Epley, Hannah K.

    2014-01-01

    There is a need for Extension professionals to show clientele the benefits of their program. This article shares how promotional videos are one way of reaching audiences online. An example is given on how a promotional video has been used and developed using iMovie software. Tips are offered for how professionals can create a promotional video and…

  20. Climate-driven regime shifts in Arctic marine benthos

    PubMed Central

    Kortsch, Susanne; Primicerio, Raul; Beuchel, Frank; Renaud, Paul E.; Rodrigues, João; Lønne, Ole Jørgen; Gulliksen, Bjørn

    2012-01-01

    Climate warming can trigger abrupt ecosystem changes in the Arctic. Despite the considerable interest in characterizing and understanding the ecological impact of rapid climate warming in the Arctic, few long time series exist that allow addressing these research goals. During a 30-y period (1980–2010) of gradually increasing seawater temperature and decreasing sea ice cover in Svalbard, we document rapid and extensive structural changes in the rocky-bottom communities of two Arctic fjords. The most striking component of the benthic reorganization was an abrupt fivefold increase in macroalgal cover in 1995 in Kongsfjord and an eightfold increase in 2000 in Smeerenburgfjord. Simultaneous changes in the abundance of benthic invertebrates suggest that the macroalgae played a key structuring role in these communities. The abrupt, substantial, and persistent nature of the changes observed is indicative of a climate-driven ecological regime shift. The ecological processes thought to drive the observed regime shifts are likely to promote the borealization of these Arctic marine communities in the coming years. PMID:22891319

  1. Climate-driven regime shifts in Arctic marine benthos.

    PubMed

    Kortsch, Susanne; Primicerio, Raul; Beuchel, Frank; Renaud, Paul E; Rodrigues, João; Lønne, Ole Jørgen; Gulliksen, Bjørn

    2012-08-28

    Climate warming can trigger abrupt ecosystem changes in the Arctic. Despite the considerable interest in characterizing and understanding the ecological impact of rapid climate warming in the Arctic, few long time series exist that allow addressing these research goals. During a 30-y period (1980-2010) of gradually increasing seawater temperature and decreasing sea ice cover in Svalbard, we document rapid and extensive structural changes in the rocky-bottom communities of two Arctic fjords. The most striking component of the benthic reorganization was an abrupt fivefold increase in macroalgal cover in 1995 in Kongsfjord and an eightfold increase in 2000 in Smeerenburgfjord. Simultaneous changes in the abundance of benthic invertebrates suggest that the macroalgae played a key structuring role in these communities. The abrupt, substantial, and persistent nature of the changes observed is indicative of a climate-driven ecological regime shift. The ecological processes thought to drive the observed regime shifts are likely to promote the borealization of these Arctic marine communities in the coming years.

  2. Gradual regime shifts in fairy circles

    PubMed Central

    Zelnik, Yuval R.; Meron, Ehud; Bel, Golan

    2015-01-01

    Large responses of ecosystems to small changes in the conditions—regime shifts—are of great interest and importance. In spatially extended ecosystems, these shifts may be local or global. Using empirical data and mathematical modeling, we investigated the dynamics of the Namibian fairy circle ecosystem as a case study of regime shifts in a pattern-forming ecosystem. Our results provide new support, based on the dynamics of the ecosystem, for the view of fairy circles as a self-organization phenomenon driven by water–vegetation interactions. The study further suggests that fairy circle birth and death processes correspond to spatially confined transitions between alternative stable states. Cascades of such transitions, possible in various pattern-forming systems, result in gradual rather than abrupt regime shifts. PMID:26362787

  3. Liquid crystal display for phase shifting

    NASA Astrophysics Data System (ADS)

    Villalobos-Mendoza, B.; Granados-Agustín, F. S.; Aguirre-Aguirre, D.; Cornejo-Rodríguez, A.

    2013-11-01

    This work arises based on the idea proposed by Millered et al. in 2004, where they show how to get in one shot interferograms with phase shift using a mask with micro-polarizers, in this work we pretend to obtain phase shift in localized areas of an interferogram using the properties of polarization and the pixelated configuration of a liquid crystal display (LCD) for testing optical surfaces. In this work we describes the process of characterization of a liquid crystal display CRL Opto and XGA2P01 model, which is introduced in one arm of a Twyman Green interferometer. Finally we show the experimental interferograms with phase shifts which are caused by different gray levels displayed in the LCD.

  4. Isotope shifts in spectra of molecular liquids

    NASA Astrophysics Data System (ADS)

    Dubrovskaya, E. V.; Kolomiitsova, T. D.; Shurukhina, A. V.; Shchepkin, D. N.

    2016-02-01

    In the IR absorption spectra of low-temperature molecular liquids, we have observed anomalously large isotope shifts of frequencies of vibrational bands that are strong in the dipole absorption. The same effect has also been observed in their Raman spectra. At the same time, in the spectra of cryosolutions, the isotope shifts of the same bands coincide with a high accuracy (±(0.1-0.5) cm-1) with the shifts that are observed in the spectra of the gas phase. The difference between the spectra of examined low-temperature systems is caused by the occurrence of resonant dipole-dipole interactions between spectrally active identical molecules. The calculation of the band contour in the spectrum of liquid freon that we have performed in this work taking into account the resonant interaction between states of simultaneous transitions in isotopically substituted molecules can explain this effect.

  5. Isotope shift measurements in titanium I

    NASA Astrophysics Data System (ADS)

    Azaroual, E. M.; Luc, P.; Vetter, R.

    1992-06-01

    The use of an effusive beam of titanium atoms crossed with a CW single-mode tunable dye laser has allowed the high-resolution, Doppler-free study of the isotope shifts between50Ti,48Ti and46Ti, for seven 3 d 2 4 s 2 a3 F J → 3 d 2 4 s 4 p z 5 D J , visible transitions of Ti I. The measurements show without ambiguity the existence of a non-negligible field shift. Using the values of the nuclear radii of titanium (coming from muonic X-ray measurements), it is possible to determine the respective values of the field and mass shifts.

  6. Multiscale regime shifts and planetary boundaries.

    PubMed

    Hughes, Terry P; Carpenter, Stephen; Rockström, Johan; Scheffer, Marten; Walker, Brian

    2013-07-01

    Life on Earth has repeatedly displayed abrupt and massive changes in the past, and there is no reason to expect that comparable planetary-scale regime shifts will not continue in the future. Different lines of evidence indicate that regime shifts occur when the climate or biosphere transgresses a tipping point. Whether human activities will trigger such a global event in the near future is uncertain, due to critical knowledge gaps. In particular, we lack understanding of how regime shifts propagate across scales, and whether local or regional tipping points can lead to global transitions. The ongoing disruption of ecosystems and climate, combined with unprecedented breakdown of isolation by human migration and trade, highlights the need to operate within safe planetary boundaries.

  7. Shift work in a security environment

    SciTech Connect

    Longhouser, G.A. Jr.

    1993-12-31

    Human beings are diurnal species, normally active by day and asleep by night. Yet over thirty million Americans struggle with work schedules that include an off-normal work effort. The railroads, law enforcement, health services, Department of Defense, factory workers, chemical plants and public services, communications and utility workers must provide some form of around-the-clock effort. Shift work has been around since the advent of recorded history. There has always been a need for some type of off-normal service and assistance. The impact of shift work is replete with tales and factual evidence of an increased personnel error rate; disorders, both personal and family, and of course, increased accident events. In recent memory, the Three Mile Island Nuclear Plant incident, Union Carbide`s explosion in Bhopal, and the Chernobyl Nuclear Plant catastrophe all occurred during off-normal working hours. Yet management overall has done little to correct the production-driven twelve hour, seven day week shift mentality of the nineteenth century. Most schedules in use today are nothing more than cosmetic variations of the old production schedules. This could be driven by a management consideration of the worker`s response to change coupled with a reluctant buy-in of responsibility for the effects of change. Florida Power Corporation has developed for its nuclear security force, a unique work schedule which attempts to employ the sound principles of circadian rhythms coupled with a comprehensive training program to counter the problems associated with shift work. The results over the last four years have seen a marked reduction in the generic problems of personnel errors, absenteeism, unscheduled overtime and turnover rates. Utilization and understanding of this scheduling process for rotational shift work needs to be assessed to determine if the benefits are site specific or provide an expected response to the problems of shift work.

  8. Gear shift controller for automatic transmission

    SciTech Connect

    Nishikawa, M.; Sakai, S.; Sakurai, T.

    1987-01-20

    A gear shift controller is described for an automatic transmission having a gear shift, comprising: a hydraulic torque converter; a gear change group, having a plurality of gears, each gear providing a different transmission ratio for the transmission of power from the hydraulic torque converter to the output of the transmission, each of the gears comprising a gear train; a one-way clutch interposed in at least one of the gear trains; a plurality of clutch means operatively connected with the gear trains for actuating each of the gear trains selectively; a gear change determination circuit operatively connected with the clutch means to control the operation of each of the clutch means according to a predetermined gear shifting program for engaging a gear train selected by the program; a coasting detection circuit for detecting a car in the coasting state; a gear shift limiting circuit, operatively connected with the gear change determination circuit and with the coasting detection circuit. The circuit is for actuating only the gear train in which the one-way clutch is interposed immediately, regardless of the selected gear train and of the operation of the gear change determination circuit, when the coasting detection circuit has determined the car to be coasting; and an operation transfer control system including a brake operation detecting means and a mode selector switch means for transferring the operation of the gear shift limiting circuit. The operation transfer control system is adapted to stop, upon detection of one of the brake operation and a reset state of the mode selector switch, the operation of the gear shift limiting circuit and to place the plurality of clutch means under the control of the gear change determination circuit.

  9. Molecular implementation of molecular shift register memories

    NASA Technical Reports Server (NTRS)

    Beratan, David N. (Inventor); Onuchic, Jose N. (Inventor)

    1991-01-01

    An electronic shift register memory (20) at the molecular level is described. The memory elements are based on a chain of electron transfer molecules (22) and the information is shifted by photoinduced (26) electron transfer reactions. Thus, multi-step sequences of charge transfer reactions are used to move charge with high efficiency down a molecular chain. The device integrates compositions of the invention onto a VLSI substrate (36), providing an example of a molecular electronic device which may be fabricated. Three energy level schemes, molecular implementation of these schemes, optical excitation strategies, charge amplification strategies, and error correction strategies are described.

  10. Nonphotic phase shifting in hamster clock mutants.

    PubMed

    Mrosovsky, N; Salmon, P A; Menaker, M; Ralph, M R

    1992-01-01

    Golden hamsters with the tau mutation were kept in the dark and induced to become active through confinement to a novel running wheel for 3 hr. The response of the mutants to this nonphotic phase-shifting stimulus differed from that of wild-type hamsters. The mutants showed larger phase shifts, and their phase response curves differed in shape, with an advance portion at about circadian time 24, a phase at which wild types show delays. The results establish that the tau mutation, in addition to its already known effects, alters the response of the circadian system to nonphotic events.

  11. Isotope shifts in methane near 6000/cm

    NASA Technical Reports Server (NTRS)

    Fox, K.; Halsey, G. W.; Jennings, D. E.

    1976-01-01

    Isotope shifts for cleanly resolved vibrational-rotational absorption lines of CH4-12 and CH4-13 were measured by a 5-m focal length Littrow spectrometer in the 6000/cm range. The methane isotopes were held in separate absorption cells: 20 torr of CH4-13 in a 1-m cell, and 5 torr of CH4-12 in a White cell of 4-m optical path length. Measured shifts for the cleanly resolved singlets R(0), R(1), Q(1) and P(1) are summarized in tabular form.

  12. Phase-shifting structures for isolated features

    NASA Astrophysics Data System (ADS)

    Garofalo, Joseph G.; Kostelak, Robert L.; Yang, Tungsheng

    1991-07-01

    The technique for improving optical projection-system resolution by phase-shifting alternate apertures of a periodic grating was introduced in 1982. This halves the frequency content of the image passing through the optics and should therefore double the effective resolution of such patterns. Unfortunately, as feature separation increases, the efficacy of this method diminishes. Previous work applying a similar approach to isolated features involves introducing minute, non-printable, phase-shifted assist slots around the desired feature. The diffraction side-lobes of these slots constructively interfere with the center lobe of the primary aperture. The resolution enhancement afforded be this technique is limited by the printability of the assist slots. This restraint also dictates 1X-size reticle feature dimensions and the employment of high contrast imaging resists. A new approach entails significantly oversizing the desired feature and introducing a phase-shifting region around the periphery. This type of structure affords substantial focus-exposure improvements and may either be fabricated in a single-level, self-aligned scheme or by a two-level exposure with conventional e-beam tools since the phase-shifting regions are on the order of 1 micrometers (reticle dimensions). Extensive modeling of this structure for isolated contact holes and spaces explores the myriad of trade- offs involved in an optimum design. Mask-fabrication tolerances, such as phase-shift uniformity, are also investigated. It is shown that the focus-exposure window enlarges as the overall structure dimensions increase. The degree of enhancement must therefore by weighed against packing density restrictions. Also, the structure suffers, to some degree, from the effect of side-lobes. However, for a given side-lobe intensity, this technique yields enhancements superior to the assist-slot approach. As is typical of phase-shifted systems, performance is improved as the partial coherence ((sigma

  13. What are 12-hour shifts good for?

    PubMed

    In the UK many hospitals use 12-hour shifts, believing it to be a cost-efficient means of providing 24-hour nursing care on wards. While healthcare organisations need to find ways to deliver nursing care around the clock and efficiency is a key consideration, nurse leaders have raised concerns about ' whether nurses can function effectively and safely when working long hours (Calkin, 2012; Rogers et al, 2004). In this Policy Plus, we focus specifically on what is known about the impact of shift length on patient safety, employee health and quality of care.

  14. Quadrature-Quadrature Phase Shift Keying.

    DTIC Science & Technology

    1986-09-01

    Q 2PSK for the data stream a (t) in Figure 3.1 ................................................ 27 3.3. Spectral densities of OQPSK , MSK and Q’PSK...Offset Quadrature Phase Shift Keying ( OQPSK ). Minimum Shift Keying ( vISK ), Quadrature Overlapped taised Cosine ( QOW signalling scheme, Tamed Frequency...orthogonal; hence the name %liniliur ’t Keving (AfSK) . The baseband power spectral densities S~.f) a1nd( o’,,, r QPSlK (or OQPSk . and NLSK are given by

  15. Shared Information Framework and Technology (SHIFT) Handbook

    DTIC Science & Technology

    2009-02-01

    Preferences‖ and click it . 29 The following page will show up: 4. Click the ―create a personal page‖ link. On following page the user...the ―Space‖ you want to view in the space listing and click it . You will end up to a folder view of the chosen space. For instance, a view of MNE5...tools) in SHIFT portal. Some of the items on the list are in form of an active link. If a link is clicked it will automatically open the SHIFT tool

  16. Shift-and-add for astronomical imaging

    NASA Technical Reports Server (NTRS)

    Ribak, Erez; Hege, E. Keith; Strobel, Nicolas V.; Christou, Julian C.

    1989-01-01

    Diffraction-limited astronomical images have been obtained utilizing a variant of the shift-and-add method. It is shown that the matched filter approach for extending the weighted shift-and-add method reduces specklegrams from extended objects and from an object dominated by photon noise. The method is aberration-insensitive and yields very high dynamic range results. The iterative method for arriving at the matched filter does not automatically converge in the case of photon-noisy specklegrams for objects with more than one maximum.

  17. Progress in speckle-shift strain measurement

    NASA Technical Reports Server (NTRS)

    Lant, Christian T.; Barranger, John P.; Oberle, Lawrence G.; Greer, Lawrence C., III

    1991-01-01

    The Instrumentation and Control Technology Division of the Lewis Research Center has been developing an in-house capability to make one dimensional and two dimensional optical strain measurements on high temperature test specimens. The measurements are based on a two-beam speckle-shift technique. The development of composite materials for use in high temperature applications is generating interest in using the speckle-shift technique to measure strains on small diameter fibers and wires of various compositions. The results of preliminary speckle correlation tests on wire and fiber specimens are covered, and the advanced system currently under development is described.

  18. Shifted Fresnel diffraction for computational holography.

    PubMed

    Muffoletto, Richard P; Tyler, John M; Tohline, Joel E

    2007-04-30

    Fourier-based approaches to calculate the Fresnel diffraction of light provide one of the most efficient algorithms for holographic computations because this permits the use of the fast Fourier transform (FFT). This research overcomes the limitations on sampling imposed by Fourier-based algorithms by the development of a fast shifted Fresnel transform. This fast shifted Fresnel transform is used to develop a tiling approach to hologram construction and reconstruction, which computes the Fresnel propagation of light between parallel planes having different resolutions.

  19. Lamb shift in the muonic helium ion

    SciTech Connect

    Martynenko, A. P.

    2007-07-15

    The Lamb shift (2P{sub 1/2}-2S{sub 1/2}) in the muonic helium ion ({mu}-{sub 2}{sup 4}He){sup +} is calculated with the account of contributions of orders {alpha}{sup 3}, {alpha}{sup 4}, {alpha}{sup 5}, and {alpha}{sup 6}. Special attention is given to corrections of the electron vacuum polarization, the nuclear structure, and recoil effects. The obtained numerical value of the Lamb shift 1381.72 meV can be considered as a reliable estimate for the comparison with experimental data.

  20. Lamb shift in the muonic deuterium atom

    SciTech Connect

    Krutov, A. A.; Martynenko, A. P.

    2011-11-15

    We present an investigation of the Lamb shift (2P{sub 1/2}-2S{sub 1/2}) in the muonic deuterium ({mu}D) atom using the three-dimensional quasipotential method in quantum electrodynamics. The vacuum polarization, nuclear-structure, and recoil effects are calculated with the account of contributions of orders {alpha}{sup 3}, {alpha}{sup 4}, {alpha}{sup 5}, and {alpha}{sup 6}. The results are compared with earlier performed calculations. The obtained numerical value of the Lamb shift at 202.4139 meV can be considered a reliable estimate for comparison with forthcoming experimental data.

  1. Direct phase-shift measurement with transmitted deep-UV illumination

    NASA Astrophysics Data System (ADS)

    Kusunose, Haruhiko; Awamura, Naoki; Takizawa, Hideo; Miyazaki, Kouji; Ode, Takahiro; Awamura, Daikichi

    1996-07-01

    This paper describes a direct phase-shift measurement system with transmitted deep-UV illumination for phase shifting mask (PSM) using a lateral shearing interferometer system. This interferometer has new structure developed for this purpose. The mirror mount of the interferometer is made of SiC ceramics that promote stability against vibration and ambient temperature drift. The illumination employs a xenon mercury arc lamp that has a spectrum close to the wavelength of KrF excimer laser. The repeatability of measurements is 0.5 degree in 3 sigma. The system can measure a small pattern down to 1 μm with an alternating type PSM with the objective of N.A.=0.4. Influence of incident angle of illumination on phase-shift measurement is investigated by experiment. The results show similar effects with simulation for circular illumination. The phase-shift measurement results on quartz step meet well with a calculation from step height and known refractive index including the effect of incident angle of illumination. The deep-UV measurement results also have good correlation with calculations from the results with another direct phase-shift measurement system that wavelength is 365nm. The simulation for focus latitude of alternating type PSMs agree with the experimental results of wafer exposure and the phase measurement. The accuracy of this system is sufficient for application to development of phase shift mask process.

  2. Persistent and pervasive compositional shifts of western boreal forest plots in Canada.

    PubMed

    Searle, Eric B; Chen, Han Y H

    2017-02-01

    Species compositional shifts have important consequences to biodiversity and ecosystem function and services to humanity. In boreal forests, compositional shifts from late-successional conifers to early-successional conifers and deciduous broadleaves have been postulated based on increased fire frequency associated with climate change truncating stand age-dependent succession. However, little is known about how climate change has affected forest composition in the background between successive catastrophic fires in boreal forests. Using 1797 permanent sample plots from western boreal forests of Canada measured from 1958 to 2013, we show that after accounting for stand age-dependent succession, the relative abundances of early-successional deciduous broadleaves and early-successional conifers have increased at the expense of late-successional conifers with climate change. These background compositional shifts are persistent temporally, consistent across all forest stand ages and pervasive spatially across the region. Rising atmospheric CO2 promoted early-successional conifers and deciduous broadleaves, and warming increased early-successional conifers at the expense of late-successional conifers, but compositional shifts were not associated with climate moisture index. Our results emphasize the importance of climate change on background compositional shifts in the boreal forest and suggest further compositional shifts as rising CO2 and warming will continue in the 21st century.

  3. The longer the shifts for hospital nurses, the higher the levels of burnout and patient dissatisfaction.

    PubMed

    Stimpfel, Amy Witkoski; Sloane, Douglas M; Aiken, Linda H

    2012-11-01

    Extended work shifts of twelve hours or longer are common and even popular with hospital staff nurses, but little is known about how such extended hours affect the care that patients receive or the well-being of nurses. Survey data from nurses in four states showed that more than 80 percent of the nurses were satisfied with scheduling practices at their hospital. However, as the proportion of hospital nurses working shifts of more than thirteen hours increased, patients' dissatisfaction with care increased. Furthermore, nurses working shifts of ten hours or longer were up to two and a half times more likely than nurses working shorter shifts to experience burnout and job dissatisfaction and to intend to leave the job. Extended shifts undermine nurses' well-being, may result in expensive job turnover, and can negatively affect patient care. Policies regulating work hours for nurses, similar to those set for resident physicians, may be warranted. Nursing leaders should also encourage workplace cultures that respect nurses' days off and vacation time, promote nurses' prompt departure at the end of a shift, and allow nurses to refuse to work overtime without retribution.

  4. The Lamb shift in the hydrogen atom: Shift of s states

    SciTech Connect

    Karshenboim, S.G.

    1995-02-01

    A theoretical expression for the difference of the Lamb shifts of the 1s{sub 1/2} and 2s{sub 1/2} levels is obtained. The Lamb shift of the ground state in the hydrogen atom is recalculated and found to be 8172.898(26) MHz. 22 refs.

  5. Work shift duration: a review comparing eight hour and 12 hour shift systems

    PubMed Central

    Smith, L.; Folkard, S.; Tucker, P.; Macdonald, I.

    1998-01-01

    OBJECTIVES: Shiftwork is now a major feature of working life across a broad range of industries. The features of the shift systems operated can impact on the wellbeing, performance, and sleep of shiftworkers. This paper reviews the current state of knowledge on one major characteristic of shift rotas-namely, shift duration. Evidence comparing the relative effects of eight hour and 12 hour shifts on fatigue and job performance, safety, sleep, and physical and psychological health are considered. At the organisational level, factors such as the mode of system implementation, attitudes towards shift rotas, sickness absence and turnover, overtime, and moonlighting are discussed. METHODS: Manual and electronic searches of the shiftwork research literature were conducted to obtain information on comparisons between eight hour and 12 hour shifts. RESULTS: The research findings are largely equivocal. The bulk of the evidence suggests few differences between eight and 12 hour shifts in the way they affect people. There may even be advantages to 12 hour shifts in terms of lower stress levels, better physical and psychological wellbeing, improved durations and quality of off duty sleep as well as improvements in family relations. On the negative side, the main concerns are fatigue and safety. It is noted that a 12 hour shift does not equate with being active for only 12 hours. CONCLUSIONS: There can be considerable extension of the person's time awake either side of the shift. However, the effects of longer term exposure to extended work days have been relatively uncharted in any systematic way. Longitudinal comparative research into the chronic impact of the compressed working week is needed.   PMID:9624275

  6. Invertebrate community response to a shifting mosaic of habitat

    USGS Publications Warehouse

    Engle, David M.; Fuhlendorf, S.D.; Roper, A.; Leslie, David M.

    2008-01-01

    Grazing management has focused largely on promoting vegetation homogeneity through uniform distribution of grazing to minimize area in a pasture that is either heavily disturbed or undisturbed. An alternative management model that couples grazing and fire (i.e., patch burning) to promote heterogeneity argues that grazing and fire interact through a series of positive and negative feedbacks to cause a shifting mosaic of vegetation composition and structure across the landscape. We compared patch burning with traditional homogeneity-based management in tallgrass prairie to determine the influence of the two treatments on the aboveground invertebrate community. Patch burning resulted in a temporal flush of invertebrate biomass in patches transitional between unburned and patches burned in the current year. Total invertebrate mass was about 50% greater in these transitional patches within patch-burned pastures as compared to pastures under traditional, homogeneity-based management. Moreover, the mosaic of patches in patch-burned pastures contained a wider range of invertebrate biomass and greater abundance of some invertebrate orders than did the traditionally managed pastures. Patch burning provides habitat that meets requirements for a broad range of invertebrate species, suggesting the potential for patch burning to benefit other native animal assemblages in the food chain.

  7. Implications of Shifting Technology in Education

    ERIC Educational Resources Information Center

    Holland, Janet; Holland, John

    2014-01-01

    This article examines the implications of shifting technology trends by looking at what we've lost or are losing, where we are, and where we need to go for making the needed transitions in knowledge and skills. Areas of growth within new media and the tech industry are good indicators of our growing interests in mobility, improved quality,…

  8. Tilting and shifting modes in a spheromak

    SciTech Connect

    Jardin, S.C.; Chance, M.S.; Dewar, R.L.; Grimm, R.C.; Monticello, D.A.

    1981-04-01

    In the absence of a conducting wall, typical spheromak plasmas are unstable to tilting and/or shifting modes. The effects of the cross-sectional shape, aspect ratio, and the location of a conducting wall on the stability of these modes are investigated.

  9. Ambiguity Produces Attention Shifts in Category Learning

    ERIC Educational Resources Information Center

    Vadillo, Miguel A.; Orgaz, Cristina; Luque, David; Nelson, James Byron

    2016-01-01

    It has been suggested that people and nonhuman animals protect their knowledge from interference by shifting attention toward the context when presented with information that contradicts their previous beliefs. Despite that suggestion, no studies have directly measured changes in attention while participants are exposed to an interference…

  10. Shifting Context: A Better Approach to Training?

    ERIC Educational Resources Information Center

    Lefkoe, Morty

    1985-01-01

    Context shifting is an approach to training that aims to transform the participants' point of view, allowing them to create a new context in which to perform their jobs, a new way of defining their roles that motivates them to exhibit skills and use information. (SK)

  11. Blackbody radiation shifts in optical atomic clocks.

    PubMed

    Safronova, Marianna; Kozlov, Mikhail; Clark, Charles

    2012-03-01

    A review of recent theoretical calculations of blackbody radiation (BBR) shifts in optical atomic clocks is presented. We summarize previous results for monovalent ions that were obtained by a relativistic all-order single-double method, where all single and double excitations of the Dirac- Fock wave function are included to all orders of perturbation theory. A recently developed method for accurate calculations of BBR shifts in divalent atoms is then presented. This approach combines the relativistic all-order method and the configuration interaction method, which provides for accurate treatment of correlation corrections in atoms with two valence electrons. Calculations of the BBR shifts in B+, Al+, and In+ have enabled us to reduce the present fractional uncertainties in the frequencies of their clock transitions as measured at room temperature: to 4 × 10-19 for Al+ and 10-18 for B+ and In+. These uncertainties approach recent estimates of the limits of precision of currently proposed optical atomic clocks. We discuss directions of future theoretical developments for reducing clock uncertainties resulting from blackbody radiation shifts.

  12. Paradigmatic Shift or Tinkering at the Edges?

    ERIC Educational Resources Information Center

    Sutherland, Margaret

    2012-01-01

    In their target paper, "Towards a systemic theory of gifted education," A. Ziegler and S. N. Phillipson present a long awaited call for a paradigmatic shift in thinking within the field of gifted education. The paper considers how educators and researchers within the field could bring about such a change. They challenge the prevailing…

  13. Heart-rate pulse-shift detector

    NASA Technical Reports Server (NTRS)

    Anderson, M.

    1974-01-01

    Detector circuit accurately separates and counts phase-shift pulses over wide range of basic pulse-rate frequency, and also provides reasonable representation of full repetitive EKG waveform. Single telemeter implanted in small animal monitors not only body temperature but also animal movement and heart rate.

  14. Deindustrialization and the Shift to Services.

    ERIC Educational Resources Information Center

    Kutscher, Ronald E.; Personick, Valerie A.

    1986-01-01

    Bureau of Labor Statistics data show the industrial sector as a whole in healthy shape, but a few manufacturing industries in deep trouble. These industries include tobacco manufacturers, iron and steel foundries, leather products, and steel manufacturers. Also examines shifts in employment and output, job quality, and outlook for the future. (CT)

  15. Hispanics Find Jobs that Shift Migration

    ERIC Educational Resources Information Center

    Gilroy, Marilyn

    2007-01-01

    Economic opportunity, the force that has driven population shifts for years, is changing the face of migration as Hispanics move into parts of the nation beyond border states and traditional ports of entry. North Carolina, Tennessee, Georgia, and Indiana are experiencing a steady growth in Hispanic population. In addition, West Virginia, Ohio, and…

  16. Gender shifts in equine veterinary practice.

    PubMed

    Heinke, Marsha L; Sabo, Carol

    2009-12-01

    This article examines gender shifts in equine veterinary practice. A significant gender compensation gap continues across the spectrum of professions, including veterinary medicine. Many styles of practice serve the disparate and sometimes conflicting goals of financial well-being, patient care, and physical family presence.

  17. Attention-Shifting in Frederick Douglass.

    ERIC Educational Resources Information Center

    Leroux, Neil R.

    A study explored rhetorical strategies and dynamics within a single speech delivered by Frederick Douglass on July 5, l852 in Rochester, New York, which was considered by speaker and audience to be an Independence Day speech. An examination of the text suggests that Douglass embarked on a strategy of attention-shifting--turning the attention of…

  18. Has the Education Paradigm Begun to Shift?

    ERIC Educational Resources Information Center

    Chadwick, Clifton B.

    2014-01-01

    The author reviews various elements of what may be considered as evidence that the long-awaited shift in the education paradigm is actually happening. Concepts like student-centered learning, attainment-based evaluation, knowledge-based constructivism, and effort-based intelligence are growing, are being more widely recognized as important, and…

  19. A Paradigm Shift to Improve Academic Performance

    ERIC Educational Resources Information Center

    Rulloda, Rudolfo B.

    2009-01-01

    A shift to computer skills for improving academic performances was investigated. The No Child Left Behind Act of 2001 increased the amount of high school dropouts after the Act was enacted. At-risk students were included in this research study. Several models described using teachers for core subjects and mentors to built citizenship skills, along…

  20. The Phase Shift in the Jumping Ring

    ERIC Educational Resources Information Center

    Jeffery, Rondo N.; Amiri, Farhang

    2008-01-01

    The popular physics demonstration experiment known as Thomson's Jumping Ring (JR) has been variously explained as a simple example of Lenz's law, or as the result of a phase shift of the ring current relative to the induced emf. The failure of the first-quadrant Lenz's law explanation is shown by the time the ring takes to jump and by levitation.…

  1. Design principles of shift current photovoltaics

    NASA Astrophysics Data System (ADS)

    Cook, Ashley; Fregoso, Benjamin; de Juan, Fernando; Moore, Joel

    While the basic principles and limitations of conventional solar cells are well understood, relatively little attention has gone toward evaluating and maximizing the potential efficiency of photovoltaic devices based on shift currents. In this work, a sum rule approach is introduced and used to outline design principles for optimizing shift currents for photon energies near the band gap, which depend on wavefunctions via Berry connections as well as standard band structure. Using these we identify two new classes of shift current photovoltaics, ferroelectric polymer films and orthorhombic monochalcogenides, both of which exhibit peak photoresponsivities larger than predictions for previously-known photovoltaics of this type. Using physically-motivated tight-binding models, the full frequency dependent response of these materials is obtained. Exploring the phase space of these models, we find photoresponsivities that can exceed 100 mA/W. These results show that considering the microscopic origin of shift current via effective models allows one to improve the possible efficiency of devices using this mechanism and better grasp their potential to compete with conventional solar cells. This work was completed with the support of an NSERC Michael Smith Foreign Study Supplement.

  2. SHIFT: Shared Information Framework and Technology Concept

    DTIC Science & Technology

    2009-02-01

    awareness tools ................................................................29 4.5.1. Map interface and GIS services...information). The information in the SHIFT situational picture can also be exported to other services. 4.5.1. Map interface and GIS services...drawings. A metadata about map quality is essential information and it can be presented as well. Geographic Information System ( GIS ) services offered by

  3. RQL Fuel Shifting Sector Rig Test

    NASA Technical Reports Server (NTRS)

    Holdeman, James D. (Technical Monitor); Haid, Daniel A.; Koopman, Frederick S.; Peschke, William O. T.; Siskind, Kenneth S.

    2004-01-01

    The low emissions potential of a Rich-Quench-Lean (RQL) combustor for use in the HIgh Speed Civil transport (HSCT) application was evaluated as part of the NASA Critical Propulsion Components (CPC) Program. Fuel shifting as an approach to combustor control was evaluated in a multiple bank RQL combustor, utilizing reduced scale quench technology implemented in a convoluted linear with quench plate concept.

  4. Core level shifts of intercalated graphene

    NASA Astrophysics Data System (ADS)

    Schröder, Ulrike A.; Petrović, Marin; Gerber, Timm; Martínez-Galera, Antonio J.; Grånäs, Elin; Arman, Mohammad A.; Herbig, Charlotte; Schnadt, Joachim; Kralj, Marko; Knudsen, Jan; Michely, Thomas

    2017-03-01

    Through intercalation of metals and gases the Dirac cone of graphene on Ir(111) can be shifted with respect to the Fermi level without becoming destroyed by strong hybridization. Here, we use x-ray photoelectron spectroscopy to measure the C 1s core level shift (CLS) of graphene in contact with a number of structurally well-defined intercalation layers (O, H, Eu, and Cs). By analysis of our own and additional literature data for decoupled graphene, the C 1s CLS is found to be a non-monotonic function of the doping level. For small doping levels the shifts are well described by a rigid band model. However, at larger doping levels, a second effect comes into play which is proportional to the transferred charge and counteracts the rigid band shift. Moreover, not only the position, but also the C 1s peak shape displays a unique evolution as a function of doping level. Our conclusions are supported by intercalation experiments with Li, with which, due to the absence of phase separation, the doping level of graphene can be continuously tuned.

  5. Majors' Shift to Natural Gas, The

    EIA Publications

    2001-01-01

    The Majors' Shift to Natural Gas investigates the factors that have guided the United States' major energy producers' growth in U.S. natural gas production relative to oil production. The analysis draws heavily on financial and operating data from the Energy Information Administration's Financial Reporting System (FRS)

  6. Survey Detects Shifting Priorities of School Boards

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    The author reports the results of a nationwide survey of school board members which show a shift in focus toward student achievement and away from district-management issues known as the "killer B's": buses, buildings, books, budgets, and bonds. But today's school board members appear not to be as interested in issues that many policy observers…

  7. Glutathione-Induced Calcium Shifts in Chick Retinal Glial Cells

    PubMed Central

    Freitas, Hercules R.; Ferraz, Gabriel; Ferreira, Gustavo C.; Ribeiro-Resende, Victor T.; Chiarini, Luciana B.; do Nascimento, José Luiz M.; Matos Oliveira, Karen Renata H.; Pereira, Tiago de Lima; Ferreira, Leonardo G. B.; Kubrusly, Regina C.; Faria, Robson X.

    2016-01-01

    Neuroglia interactions are essential for the nervous system and in the retina Müller cells interact with most of the neurons in a symbiotic manner. Glutathione (GSH) is a low-molecular weight compound that undertakes major antioxidant roles in neurons and glia, however, whether this compound could act as a signaling molecule in neurons and/or glia is currently unknown. Here we used embryonic avian retina to obtain mixed retinal cells or purified Müller glia cells in culture to evaluate calcium shifts induced by GSH. A dose response curve (0.1–10mM) showed that 5–10mM GSH, induced calcium shifts exclusively in glial cells (later labeled and identified as 2M6 positive cells), while neurons responded to 50mM KCl (labeled as βIII tubulin positive cells). BBG 100nM, a P2X7 blocker, inhibited the effects of GSH on Müller glia. However, addition of DNQX 70μM and MK-801 20μM, non-NMDA and NMDA blockers, had no effect on GSH calcium induced shift. Oxidized glutathione (GSSG) at 5mM failed to induce calcium mobilization in glia cells, indicating that the antioxidant and/or structural features of GSH are essential to promote elevations in cytoplasmic calcium levels. Indeed, a short GSH pulse (60s) protects Müller glia from oxidative damage after 30 min of incubation with 0.1% H2O2. Finally, GSH induced GABA release from chick embryonic retina, mixed neuron-glia or from Müller cell cultures, which were inhibited by BBG or in the absence of sodium. GSH also induced propidium iodide uptake in Müller cells in culture in a P2X7 receptor dependent manner. Our data suggest that GSH, in addition to antioxidant effects, could act signaling calcium shifts at the millimolar range particularly in Müller glia, and could regulate the release of GABA, with additional protective effects on retinal neuron-glial circuit. PMID:27078878

  8. Nitrate Intake Promotes Shift in Muscle Fiber Type Composition during Sprint Interval Training in Hypoxia

    PubMed Central

    De Smet, Stefan; Van Thienen, Ruud; Deldicque, Louise; James, Ruth; Sale, Craig; Bishop, David J.; Hespel, Peter

    2016-01-01

    Purpose: We investigated the effect of sprint interval training (SIT) in normoxia, vs. SIT in hypoxia alone or in conjunction with oral nitrate intake, on buffering capacity of homogenized muscle (βhm) and fiber type distribution, as well as on sprint and endurance performance. Methods: Twenty-seven moderately-trained participants were allocated to one of three experimental groups: SIT in normoxia (20.9% FiO2) + placebo (N), SIT in hypoxia (15% FiO2) + placebo (H), or SIT in hypoxia + nitrate supplementation (HN). All participated in 5 weeks of SIT on a cycle ergometer (30-s sprints interspersed by 4.5 min recovery-intervals, 3 weekly sessions, 4–6 sprints per session). Nitrate (6.45 mmol NaNO3) or placebo capsules were administered 3 h before each session. Before and after SIT participants performed an incremental VO2max-test, a 30-min simulated cycling time-trial, as well as a 30-s cycling sprint test. Muscle biopsies were taken from m. vastus lateralis. Results: SIT decreased the proportion of type IIx muscle fibers in all groups (P < 0.05). The relative number of type IIa fibers increased (P < 0.05) in HN (P < 0.05 vs. H), but not in the other groups. SIT had no significant effect on βhm. Compared with H, SIT tended to enhance 30-s sprint performance more in HN than in H (P = 0.085). VO2max and 30-min time-trial performance increased in all groups to a similar extent. Conclusion: SIT in hypoxia combined with nitrate supplementation increases the proportion of type IIa fibers in muscle, which may be associated with enhanced performance in short maximal exercise. Compared with normoxic training, hypoxic SIT does not alter βhm or endurance and sprinting exercise performance. PMID:27378942

  9. Explorations in Promoting Conceptual Change in Electrical Concepts via Ontological Category Shift.

    ERIC Educational Resources Information Center

    Lee, Yeung; Law, Nancy

    2001-01-01

    Discusses difficulties encountered by students in learning physics concepts that arise because they attribute ontology of material substance to these concepts. Reports on a series of four studies that explored the usefulness of an ontological categorization framework in investigating students' alternative conceptions of electric circuits and…

  10. Submerged vegetation removal promotes shift of dominant phytoplankton functional groups in a eutrophic lake.

    PubMed

    Dong, Jing; Yang, Kai; Li, Shuangshuang; Li, Genbao; Song, Lirong

    2014-08-01

    Historical data indicate that the dominance of submerged plants in Dianchi Lake in the 1960s was characterized by low algal density with dominance of non-toxic group J (Scenedesmus, Pediastrum, etc.). The removal of submerged plants, which began in the 1970s, resulted in the expansion of bloom-forming Microcystis (group M). Laboratory experiments suggested that Microcystis aeruginosa was inclined to grow and develop at elevated temperatures. The growth of Scenedesmus obliquus was slower than that of co-cultivated M. aeruginosa in the absence of Ceratophyllum demersum, especially at higher temperatures. The existence of submerged plant C. demersum could inhibit the growth of the harmful algae M. aeruginosa and this inhibitory effect by C. demersum was enhanced with an increase in temperature. Instead, with C. demersum, the growth of S. obliquus was not inhibited, but the co-cultivated M. aeruginosa was eliminated in a short time. Combined with the historical data and laboratory experiments, it was indicated that the submerged plants might play important roles in the dominance of the non-toxic group J in the historical succession. Consequently, the introduction of the submerged plant such as C. demersum might alter the dominant phytoplankton functional groups from M to J and benefit the restoration of the eutrophic lake.

  11. Shift in precipitation regime promotes interspecific hybridization of introduced Coffea species.

    PubMed

    Gomez, Céline; Despinoy, Marc; Hamon, Serge; Hamon, Perla; Salmon, Danyela; Akaffou, Doffou Sélastique; Legnate, Hyacinthe; de Kochko, Alexandre; Mangeas, Morgan; Poncet, Valérie

    2016-05-01

    The frequency of plant species introductions has increased in a highly connected world, modifying species distribution patterns to include areas outside their natural ranges. These introductions provide the opportunity to gain new insight into the importance of flowering phenology as a component of adaptation to a new environment. Three Coffea species, C. arabica, C. canephora (Robusta), and C. liberica, native to intertropical Africa have been introduced to New Caledonia. On this archipelago, a secondary contact zone has been characterized where these species coexist, persist, and hybridize spontaneously. We investigated the impact of environmental changes undergone by each species following its introduction in New Caledonia on flowering phenology and overcoming reproductive barriers between sister species. We developed species distribution models and compared both environmental envelopes and climatic niches between native and introduced hybrid zones. Flowering phenology was monitored in a population in the hybrid zone along with temperature and precipitation sequences recorded at a nearby weather station. The extent and nature of hybridization events were characterized using chloroplast and nuclear microsatellite markers. The three Coffea species encountered weak environmental suitability compared to their native ranges when introduced to New Caledonia, especially C. arabica and C. canephora. The niche of the New Caledonia hybrid zone was significantly different from all three species' native niches based on identity tests (I Similarity and D Schoener's Similarity Indexes). This area appeared to exhibit intermediate conditions between the native conditions of the three species for temperature-related variables and divergent conditions for precipitation-related ones. Flowering pattern in these Coffea species was shown to have a strong genetic component that determined the time between the triggering rain and anthesis (flower opening), specific to each species. However, a precipitation regime different from those in Africa was directly involved in generating partial flowering overlap between species and thus in allowing hybridization and interspecific gene flow. Interspecific hybrids accounted for 4% of the mature individuals in the sympatric population and occurred between each pair of species with various level of introgression. Adaptation to new environmental conditions following introduction of Coffea species to New Caledonia has resulted in a secondary contact between three related species, which would not have happened in their native ranges, leading to hybridization and gene flow.

  12. Teachers' Roles in Promoting Students' Learner Autonomy in China

    ERIC Educational Resources Information Center

    Fumin, Fang; Li, Zhang

    2012-01-01

    Since 2007, the Ministry of Education of China has been promoting a shift from traditional teaching models to a new teaching model where students' autonomous learning skills can be enhanced. In particular, college students are encouraged to learn English free from the constraints of time or place. While learner autonomy has been perceived as…

  13. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder

    PubMed Central

    Åkerstedt, Torbjörn; Wright, Kenneth P.

    2010-01-01

    Shift work is highly prevalent in industrialized societies (>20%) but, when it includes night work, it has pronounced negative effects on sleep, subjective and physiological sleepiness, performance, accident risk, as well as on health outcomes such as cardiovascular disease and certain forms of cancer. The reason is the conflict between the day oriented circadian physiology and the requirement for work and sleep at the “wrong” biological time of day. Other factors that negatively impact work shift sleepiness and accident risk include long duration shifts greater than 12 hours and individual vulnerability for phase intolerance that may lead to a diagnosis of shift work disorder; i.e., those shift workers with the greatest sleepiness and performance impairment during the biological night and insomnia during the biological day. Whereas some countermeasures may be used to ameliorate the negative impact of shift work on nighttime sleepiness and daytime insomnia (combined countermeasures may be the best available), there seems at present to be no way to eliminate most of the negative effects of shift work on human physiology and cognition. PMID:20640236

  14. Health promotion in Brazil.

    PubMed

    Buss, Paulo Marchiori; de Carvalho, Antonio Ivo

    2007-01-01

    The evolution of health promotion within the Brazilian health system is examined, including an assessment of the intersectoral and development policies that have influenced the process. Particular attention is paid to the legal characteristics of the Unified Health System. Human resources formation and research initiatives in health promotion are outlined, with a summary of the obstacles that need to be overcome in order to ensure the effective implementation of health promotion in the future. Up to the end of the 20th Century health promotion was not used as a term in the Brazilian public heath context. Health promoting activities were concentrated in the area of health education, although targeting the social determinants of health and the principle of intersectoral action were part of the rhetoric. The situation has changed during the last decade, with the publication of a national policy of health promotion, issued by the Ministry of Health and jointly implemented with the States and Municipals Health Secretaries. More recently there has been a re-emergence of the discourse on the social determinants of health and the formation of intersectoral public policies as the basis of a comprehensive health promotion. Health promotion infrastructure, particularly around human resources and financing, requires strengthening in order to ensure capacity and sustainability in health promotion practice.

  15. Body Size Shifts in Philippine Reef Fishes: Interfamilial Variation in Responses to Protection

    PubMed Central

    Fidler, Robert Y.; Maypa, Aileen; Apistar, Dean; White, Alan; Turingan, Ralph G.

    2014-01-01

    As a consequence of intense fishing pressure, fished populations experience reduced population sizes and shifts in body size toward the predominance of smaller and early maturing individuals. Small, early-maturing fish exhibit significantly reduced reproductive output and, ultimately, reduced fitness. As part of resource management and biodiversity conservation programs worldwide, no-take marine protected areas (MPAs) are expected to ameliorate the adverse effects of fishing pressure. In an attempt to advance our understanding of how coral reef MPAs meet their long-term goals, this study used visual census data from 23 MPAs and fished reefs in the Philippines to address three questions: (1) Do MPAs promote shifts in fish body size frequency distribution towards larger body sizes when compared to fished reefs? (2) Do MPA size and (3) age contribute to the efficacy of MPAs in promoting such shifts? This study revealed that across all MPAs surveyed, the distribution of fishes between MPAs and fished reefs were similar; however, large-bodied fish were more abundant within MPAs, along with small, young-of-the-year individuals. Additionally, there was a significant shift in body size frequency distribution towards larger body sizes in 12 of 23 individual reef sites surveyed. Of 22 fish families, eleven demonstrated significantly different body size frequency distributions between MPAs and fished reefs, indicating that shifts in the size spectrum of fishes in response to protection are family-specific. Family-level shifts demonstrated a significant, positive correlation with MPA age, indicating that MPAs become more effective at increasing the density of large-bodied fish within their boundaries over time. PMID:24833509

  16. Robust phase-shift estimation method for statistical generalized phase-shifting digital holography.

    PubMed

    Yoshikawa, Nobukazu; Shiratori, Takaaki; Kajihara, Kazuki

    2014-06-16

    We propose a robust phase-shift estimation method for statistical generalized phase-shifting digital holography using a slightly off-axis optical configuration. The phase randomness condition in the Fresnel diffraction field of an object can be sufficiently established by the linear phase factor of the oblique incident reference wave. Signed phase-shift values can be estimated with a statistical approach regardless of the statistical properties of the Fresnel diffraction field of the object. We present computer simulations and optical experiments to verify the proposed method.

  17. Two-step phase-shifting SPIDER

    PubMed Central

    Zheng, Shuiqin; Cai, Yi; Pan, Xinjian; Zeng, Xuanke; Li, Jingzhen; Li, Ying; Zhu, Tianlong; Lin, Qinggang; Xu, Shixiang

    2016-01-01

    Comprehensive characterization of ultrafast optical field is critical for ultrashort pulse generation and its application. This paper combines two-step phase-shifting (TSPS) into the spectral phase interferometry for direct electric-field reconstruction (SPIDER) to improve the reconstruction of ultrafast optical-fields. This novel SPIDER can remove experimentally the dc portion occurring in traditional SPIDER method by recording two spectral interferograms with π phase-shifting. As a result, the reconstructed results are much less disturbed by the time delay between the test pulse replicas and the temporal widths of the filter window, thus more reliable. What is more, this SPIDER can work efficiently even the time delay is so small or the measured bandwidth is so narrow that strong overlap happens between the dc and ac portions, which allows it to be able to characterize the test pulses with complicated temporal/spectral structures or narrow bandwidths. PMID:27666528

  18. Shape-shifting colloids via stimulated dewetting

    PubMed Central

    Youssef, Mena; Hueckel, Theodore; Yi, Gi-Ra; Sacanna, Stefano

    2016-01-01

    The ability to reconfigure elementary building blocks from one structure to another is key to many biological systems. Bringing the intrinsic adaptability of biological systems to traditional synthetic materials is currently one of the biggest scientific challenges in material engineering. Here we introduce a new design concept for the experimental realization of self-assembling systems with built-in shape-shifting elements. We demonstrate that dewetting forces between an oil phase and solid colloidal substrates can be exploited to engineer shape-shifting particles whose geometry can be changed on demand by a chemical or optical signal. We find this approach to be quite general and applicable to a broad spectrum of materials, including polymers, semiconductors and magnetic materials. This synthetic methodology can be further adopted as a new experimental platform for designing and rapidly prototyping functional colloids, such as reconfigurable micro swimmers, colloidal surfactants and switchable building blocks for self-assembly. PMID:27426418

  19. Two-step phase-shifting SPIDER

    NASA Astrophysics Data System (ADS)

    Zheng, Shuiqin; Cai, Yi; Pan, Xinjian; Zeng, Xuanke; Li, Jingzhen; Li, Ying; Zhu, Tianlong; Lin, Qinggang; Xu, Shixiang

    2016-09-01

    Comprehensive characterization of ultrafast optical field is critical for ultrashort pulse generation and its application. This paper combines two-step phase-shifting (TSPS) into the spectral phase interferometry for direct electric-field reconstruction (SPIDER) to improve the reconstruction of ultrafast optical-fields. This novel SPIDER can remove experimentally the dc portion occurring in traditional SPIDER method by recording two spectral interferograms with π phase-shifting. As a result, the reconstructed results are much less disturbed by the time delay between the test pulse replicas and the temporal widths of the filter window, thus more reliable. What is more, this SPIDER can work efficiently even the time delay is so small or the measured bandwidth is so narrow that strong overlap happens between the dc and ac portions, which allows it to be able to characterize the test pulses with complicated temporal/spectral structures or narrow bandwidths.

  20. Phase-shifting color digital holography.

    PubMed

    Yamaguchi, Ichirou; Matsumura, Tatsuki; Kato, Jun-Ichi

    2002-07-01

    Digital holography with a three-wavelength laser and a color CCD has been demonstrated. With the phase shifting of the reference beam, in-line holograms for three wavelengths are recorded simultaneously for derivation of the complex amplitude at each wavelength, and then the three monochromatic images are reconstructed and combined into full-color images in the computer. Laser power variation for wavelengths can be compensated for in the reconstruction process. We have compared the images reconstructed by two algorithms using a single Fourier transformation and a convolution with each other by both experiments and numerical simulations. Phase-shifting errors arising at two of the three wavelengths have proved not to cause serious deterioration of the reconstructed images.

  1. Phase-Shifting Zernike Interferometer Wavefront Sensor

    NASA Technical Reports Server (NTRS)

    Wallace, J. Kent; Rao, Shanti; Jensen-Clemb, Rebecca M.; Serabyn, Gene

    2011-01-01

    The canonical Zernike phase-contrast technique1,2,3,4 transforms a phase object in one plane into an intensity object in the conjugate plane. This is done by applying a static pi/2 phase shift to the central core (approx. lambda/D) of the PSF which is intermediate between the input and output planes. Here we present a new architecture for this sensor. First, the optical system is simple and all reflective. Second, the phase shift in the central core of the PSF is dynamic and or arbitrary size. This common-path, all-reflective design makes it minimally sensitive to vibration, polarization and wavelength. We review the theory of operation, describe the optical system, summarize numerical simulations and sensitivities and review results from a laboratory demonstration of this novel instrument

  2. Phase-Shifting Zernike Interferometer Wavefront Sensor

    NASA Technical Reports Server (NTRS)

    Wallace, J. Kent; Rao, Shanti; Jensen-Clem, Rebecca M.

    2011-01-01

    The canonical Zernike phase-contrast technique transforms a phase object in one plane into an intensity object in the conjugate plane. This is done by applying a static pi/2 phase shift to the central core (approx. lambda/diameter) of the PSF which is intermediate between the input and output plane. Here we present a new architecture for this sensor. First, the optical system is simple and all reflective, and second the phase shift in the central core of the PSF is dynamic and can be made arbitrarily large. This common-path, all-reflective design makes it minimally sensitive to vibration, polarization and wavelength. We review the theory of operation, describe the optical system, summarize numerical simulations and sensitivities and review results from a laboratory demonstration of this novel instrument.

  3. Forensic voice comparison and the paradigm shift.

    PubMed

    Morrison, Geoffrey Stewart

    2009-12-01

    We are in the midst of a paradigm shift in the forensic comparison sciences. The new paradigm can be characterised as quantitative data-based implementation of the likelihood-ratio framework with quantitative evaluation of the reliability of results. The new paradigm was widely adopted for DNA profile comparison in the 1990s, and is gradually spreading to other branches of forensic science, including forensic voice comparison. The present paper first describes the new paradigm, then describes the history of its adoption for forensic voice comparison over approximately the last decade. The paradigm shift is incomplete and those working in the new paradigm still represent a minority within the forensic-voice-comparison community.

  4. Eliminating light shifts for single atom trapping

    NASA Astrophysics Data System (ADS)

    Hutzler, Nicholas R.; Liu, Lee R.; Yu, Yichao; Ni, Kang-Kuen

    2017-02-01

    Microscopically controlled neutral atoms in optical tweezers and lattices have led to exciting advances in the study of quantum information and quantum many-body systems. The light shifts of atomic levels from the trapping potential in these systems can result in detrimental effects such as fluctuating dipole force heating, inhomogeneous detunings, and inhibition of laser cooling, which limits the atomic species that can be manipulated. In particular, these light shifts can be large enough to prevent loading into optical tweezers directly from a magneto-optical trap. We implement a general solution to these limitations by loading, as well as cooling and imaging the atoms with temporally alternating beams, and present an analysis of the role of heating and required cooling for single atom tweezer loading. Because this technique does not depend on any specific spectral properties, it should enable the optical tweezer platform to be extended to nearly any atomic or molecular species that can be laser cooled and optically trapped.

  5. Protein structure determination from NMR chemical shifts.

    PubMed

    Cavalli, Andrea; Salvatella, Xavier; Dobson, Christopher M; Vendruscolo, Michele

    2007-06-05

    NMR spectroscopy plays a major role in the determination of the structures and dynamics of proteins and other biological macromolecules. Chemical shifts are the most readily and accurately measurable NMR parameters, and they reflect with great specificity the conformations of native and nonnative states of proteins. We show, using 11 examples of proteins representative of the major structural classes and containing up to 123 residues, that it is possible to use chemical shifts as structural restraints in combination with a conventional molecular mechanics force field to determine the conformations of proteins at a resolution of 2 angstroms or better. This strategy should be widely applicable and, subject to further development, will enable quantitative structural analysis to be carried out to address a range of complex biological problems not accessible to current structural techniques.

  6. Is the Lamb shift chemically significant?

    NASA Technical Reports Server (NTRS)

    Dyall, Kenneth G.; Bauschlicher, Charles W., Jr.; Schwenke, David W.; Pyykko, Pekka; Arnold, James (Technical Monitor)

    2001-01-01

    The contribution of the Lamb shift to the atomization energies of some prototype molecules, BF3, AlF3, and GaF3, is estimated by a perturbation procedure. It is found to be in the range of 3-5% of the one-electron scalar relativistic contribution to the atomization energy. The maximum absolute value is 0.2 kcal/mol for GaF3. These sample calculations indicate that the Lamb shift is probably small enough to be neglected for energetics of molecules containing light atoms if the target accuracy is 1 kcal/mol, but for higher accuracy calculations and for molecules containing heavy elements it must be considered.

  7. Shape-shifting colloids via stimulated dewetting

    NASA Astrophysics Data System (ADS)

    Youssef, Mena; Hueckel, Theodore; Yi, Gi-Ra; Sacanna, Stefano

    2016-07-01

    The ability to reconfigure elementary building blocks from one structure to another is key to many biological systems. Bringing the intrinsic adaptability of biological systems to traditional synthetic materials is currently one of the biggest scientific challenges in material engineering. Here we introduce a new design concept for the experimental realization of self-assembling systems with built-in shape-shifting elements. We demonstrate that dewetting forces between an oil phase and solid colloidal substrates can be exploited to engineer shape-shifting particles whose geometry can be changed on demand by a chemical or optical signal. We find this approach to be quite general and applicable to a broad spectrum of materials, including polymers, semiconductors and magnetic materials. This synthetic methodology can be further adopted as a new experimental platform for designing and rapidly prototyping functional colloids, such as reconfigurable micro swimmers, colloidal surfactants and switchable building blocks for self-assembly.

  8. Parallel phase-shifting color digital holography using two phase shifts.

    PubMed

    Kakue, Takashi; Tahara, Tatsuki; Ito, Kenichi; Shimozato, Yuki; Awatsuji, Yasuhiro; Nishio, Kenzo; Ura, Shogo; Kubota, Toshihiro; Matoba, Osamu

    2009-12-01

    We propose parallel phase-shifting color digital holography using two phase shifts. This technique enables the instantaneous acquisition of three-dimensional information of a moving color object. The interference fringe image that contains six holograms with two phase shifts for three wavelengths is recorded by a single shot exposure. Decreasing the degree of space-division multiplexing of these holograms makes it possible to suppress the degradation of the image quality owing to the aliasing caused by the multiplexing. Numerical simulation and preliminary experiments demonstrate the validity of the proposed technique; the reconstructed images of the proposed technique are clearer than those of the previously reported single-shot phase-shifting color digital holography that uses four phase steps.

  9. Written Language Shift among Norwegian Youth

    ERIC Educational Resources Information Center

    Özerk, Kamil; Todal, Jon

    2013-01-01

    In Norway there are two written Norwegian languages, Bokmâl and Nynorsk. Of these two written languages Bokmâl is being used by the majority of the people, and Bokmâl has the highest prestige in the society. This article is about the shift of written language from Nynorsk to Bokmâl among young people in a traditional Nynorsk district in the…

  10. Exploring Insight: Focus on Shifts of Attention

    ERIC Educational Resources Information Center

    Palatnik, Alik; Koichu, Boris

    2015-01-01

    The paper presents and analyses a sequence of events that preceded an insight solution to a challenging problem in the context of numerical sequences. A three­week long solution process by a pair of ninth­-grade students is analysed by means of the theory of shifts of attention. The goal for this article is to reveal the potential of this theory…

  11. The Shifting Balance of Military Power

    DTIC Science & Technology

    1970-09-30

    shifting of the strategic military balance against the United States and in favor of the Soviet Union .** These trends include: (i) the growing Soviet...deployment thereof; (iii) the possibility that present U.S. technological superiority will be lost to the Soviet Union ; (iv) the convincing evidence...that the Soviet Union seeks a preemptive first-strike capability; (v) the rapidly ex- panding Soviet naval capability; and (vi) the mounting hostility

  12. Digital phase-shifting point diffraction interferometer.

    PubMed

    Akondi, Vyas; Jewel, A R; Vohnsen, Brian

    2014-03-15

    A digital phase-shifting (PS) point diffraction interferometer is demonstrated with a transmitting liquid crystal spatial light modulator. This novel wavefront sensor allows tunability in the choice of pinhole size and eliminates the need for mechanically moving parts to achieve PS. It is shown that this wavefront sensor is capable of sensing Zernike aberrations introduced with a deformable mirror. The results obtained are compared with those of a commercial Hartmann-Shack wavefront sensor.

  13. Collisionally induced atomic clock shifts and correlations

    SciTech Connect

    Band, Y. B.; Osherov, I.

    2011-07-15

    We develop a formalism to incorporate exchange symmetry considerations into the calculation of collisional frequency shifts for atomic clocks using a density-matrix formalism. The formalism is developed for both fermionic and bosonic atomic clocks. Numerical results for a finite-temperature {sup 87}Sr {sup 1}S{sub 0} (F=9/2) atomic clock in a magic wavelength optical lattice are presented.

  14. Simple phase-shifting lateral shearing interferometer.

    PubMed

    Mihaylova, Emilia; Whelan, Maurice; Toal, Vincent

    2004-06-01

    A phase-shifting electronic speckle pattern shearing interferometer with a very simple shearing device is proposed. Two partially reflective glass plates are used to introduce the shear in this new interferometer. The reflection coefficients of the coatings on the two plates are 0.3 and 0.7. The distance between the two glass plates controls the size of the shear. The proposed new interferometric system is simple, flexible, and low cost.

  15. High expression Zymomonas promoters

    DOEpatents

    Viitanen, Paul V.; Tao, Luan; Zhang, Yuying; Caimi, Perry G.; McCole, Laura : Zhang, Min; Chou, Yat-Chen; McCutchen, Carol M.; Franden, Mary Ann

    2011-08-02

    Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.

  16. Health Promotion Program.

    ERIC Educational Resources Information Center

    McClary, Cheryl

    The Health Promotion Program began with establishment of a one-credit course in health promotion and wellness and the training of family practice residents at the Mountain Area Health Education Center to serve as lab leaders in the course. The course later became part of the university's general education requirements. In addition, a health…

  17. Promoting Resilience in Children.

    ERIC Educational Resources Information Center

    Rolfe, Sharne A.

    2002-01-01

    This booklet invites reflection on ways in which childhood resilience can be promoted, thereby helping children to adapt effectively in the face of adversity. The attributes of resilient children are described, as is the importance of protective factors in building or promoting resilience. The booklet discusses the complex interplay between risk…

  18. A Shifted Double-Diamond Titania Scaffold.

    PubMed

    Li, Hong; Liu, Ye; Cao, Xin; Han, Lu; Jiang, Chun; Che, Shunai

    2017-01-16

    Photonic crystals are expected to be metamaterials because of their potential to control the propagation of light in the linear and nonlinear regimes. Biological single-network, triply periodic constant mean curvature surface structures are considered excellent candidates owing to their large complete band gap. However, the chemical construction of these relevant structures is rare and developing new structures from thermodynamically stable double-network self-organizing systems is challenging. Herein, we reveal that the shifted double-diamond titania scaffold can achieve a complete band gap. The largest (7.71 %) band gap is theoretically obtained by shifting 0.332 c with the dielectric contrast of titania (6.25). A titania scaffold with similar shifted double-diamond structure was fabricated using a reverse core-shell microphase-templating system with an amphiphilic diblock copolymer and a titania source in a mixture of tetrahydrofuran and water, which could result in a 2.05-3.78 % gap.

  19. Atomic clocks with suppressed blackbody radiation shift.

    PubMed

    Yudin, V I; Taichenachev, A V; Okhapkin, M V; Bagayev, S N; Tamm, Chr; Peik, E; Huntemann, N; Mehlstäubler, T E; Riehle, F

    2011-07-15

    We develop a concept of atomic clocks where the blackbody radiation shift and its fluctuations can be suppressed by 1-3 orders of magnitude independent of the environmental temperature. The suppression is based on the fact that in a system with two accessible clock transitions (with frequencies ν1 and ν2) which are exposed to the same thermal environment, there exists a "synthetic" frequency ν(syn) ∝ (ν1 - ε12ν2) largely immune to the blackbody radiation shift. For example, in the case of 171Yb+ it is possible to create a synthetic-frequency-based clock in which the fractional blackbody radiation shift can be suppressed to the level of 10(-18) in a broad interval near room temperature (300±15  K). We also propose a realization of our method with the use of an optical frequency comb generator stabilized to both frequencies ν1 and ν2, where the frequency ν(syn) is generated as one of the components of the comb spectrum.

  20. Thermal field theories and shifted boundary conditions

    NASA Astrophysics Data System (ADS)

    Giusti, L.; Meyer, H.

    The analytic continuation to an imaginary velocity of the canonical partition function of a thermal system expressed in a moving frame has a natural implementation in the Euclidean path-integral formulation in terms of shifted boundary conditions. The Poincare' invariance underlying a relativistic theory implies a dependence of the free-energy on the compact length L_0 and the shift xi only through the combination beta=L_0(1+xi^2)^(1/2). This in turn implies that the energy and the momentum distributions of the thermal theory are related, a fact which is encoded in a set of Ward identities among the correlators of the energy-momentum tensor. The latter have interesting applications in lattice field theory: they offer novel ways to compute thermodynamic potentials, and a set of identities to renormalize non-perturbatively the energy-momentum tensor. At fixed bare parameters the shifted boundary conditions also provide a simple method to vary the temperature in much smaller steps than with the standard procedure.

  1. Projecting the risk of future climate shifts

    NASA Astrophysics Data System (ADS)

    Enfield, David B.; Cid-Serrano, Luis

    2006-06-01

    Recent research has shown that decadal-to-multidecadal (D2M) climate variability is associated with environmental changes that have important consequences for human activities, such as public health, water availability, frequency of hurricanes, and so forth. As scientists, how do we convert these relationships into decision support products useful to water managers, insurance actuaries, and others, whose principal interest lies in knowing when future climate regime shifts will likely occur that affect long-horizon decisions? Unfortunately, numerical models are far from being able to make deterministic predictions for future D2M climate shifts. However, the recent development of paleoclimate reconstructions of the Atlantic Multidecadal Oscillation (AMO) (Gray et al., [2004]) and Pacific Decadal Oscillation (PDO); (MacDonald and Case, [2005]) give us a viable alternative: to estimate probability distribution functions from long climate index series that allow us to calculate the probability of future D2M regime shifts. In this paper, we show how probabilistic projections can be developed for a specific climate mode - the AMO as represented by the Gray et al. ([2004]) tree-ring reconstruction. The methods are robust and can be applied to any D2M climate mode for which a sufficiently long index series exists, as well as to the growing body of paleo-proxy reconstructions that have become available. The target index need not be a paleo-proxy calibrated against a climate index; it may profitably be calibrated against a specific resource of interest, such as stream flow or lake levels.

  2. Bashful ballerina: Southward shifted heliospheric current sheet

    NASA Astrophysics Data System (ADS)

    Mursula, K.; Hiltula, T.

    2003-11-01

    It is known since long [Rosenberg and Coleman, 1969] that one of the two sectors of the interplanetary magnetic field (IMF) observed at the Earth's orbit dominates at high heliographic latitudes during solar minimum times, reflecting the poloidal structure of the global solar magnetic field at these times. Here we find that while this latitudinal variation of the dominant IMF sector around the solar equator is valid for both solar hemispheres during the last four solar minima covered by direct observations, it is systematically more strongly developed in the northern heliographic hemisphere. This implies that the average heliospheric current sheet is shifted or coned southward during solar minimum times, suggesting that the temporary southward shift of the heliosheet found earlier by Ulysses observations in 1995 is a persistent pattern. This also implies that the open solar magnetic field is north-south asymmetric at these times, suggesting that the solar dynamo has an asymmetric component. Accordingly, the Sun with the heliosheet is like a bashful ballerina who is repeatedly trying to push her excessively high flaring skirt downward. However, the effective shift at 1 AU is only a few degrees, allowing the Rosenberg-Coleman rule to be valid, on an average, in both hemispheres during solar minima.

  3. Bashful Ballerina: Southward shifted Heliospheric Current Sheet

    NASA Astrophysics Data System (ADS)

    Mursula, K.; Hiltula, T.

    It is known since long (Rosenberg and Coleman, 1969) that one of the two sectors of the interplanetary magnetic field (IMF) observed at the Earth's orbit dominates at high heliographic latitudes during solar minimum times, reflecting the poloidal structure of the global solar magnetic field at these times. Here we find that while this latitudinal variation of the dominant IMF sector around the solar equator is valid for both solar hemispheres during the last four solar minima covered by direct observations, it is systematically more strongly developed in the northern heliographic hemisphere. This implies that the average heliospheric current sheet is shifted or coned southward during solar minimum times, suggesting that the temporary southward shift of the heliosheet found earlier by Ulysses observations in 1995 is a persistent pattern. This also implies that the open solar magnetic field is north-south asymmetric at these times, suggesting that the solar dynamo has an asymmetric component. Accordingly, the Sun with the heliosheet is like a bashful ballerina who is repeatedly trying to push her excessively high flaring skirt downward. However, the effective shift at 1 AU is only a few degrees, allowing the Rosenberg-Coleman rule to be valid, on an average, in both hemispheres during solar minima.

  4. Michelson interferometer based spatial phase shift shearography.

    PubMed

    Xie, Xin; Yang, Lianxiang; Xu, Nan; Chen, Xu

    2013-06-10

    This paper presents a simple spatial phase shift shearography based on the Michelson interferometer. The Michelson interferometer based shearographic system has been widely utilized in industry as a practical nondestructive test tool. In the system, the Michelson interferometer is used as a shearing device to generate a shearing distance by tilting a small angle in one of the two mirrors. In fact, tilting the mirror in the Michelson interferometer also generates spatial frequency shift. Based on this feature, we introduce a simple Michelson interferometer based spatial phase shift shearography. The Fourier transform (FT) method is applied to separate the spectrum on the spatial frequency domain. The phase change due to the loading can be evaluated using a properly selected windowed inverse-FT. This system can generate a phase map of shearography by using only a single image. The effects of shearing angle, spatial resolution of couple charge device camera, and filter methods are discussed in detail. The theory and the experimental results are presented.

  5. Is there a shift to "active nanostructures"?

    NASA Astrophysics Data System (ADS)

    Subramanian, Vrishali; Youtie, Jan; Porter, Alan L.; Shapira, Philip

    2010-01-01

    It has been suggested that an important transition in the long-run trajectory of nanotechnology development is a shift from passive to active nanostructures. Such a shift could present different or increased societal impacts and require new approaches for risk assessment. An active nanostructure "changes or evolves its state during its operation," according to the National Science Foundation's (2006) Active Nanostructures and Nanosystems grant solicitation. Active nanostructure examples include nanoelectromechanical systems (NEMS), nanomachines, self-healing materials, targeted drugs and chemicals, energy storage devices, and sensors. This article considers two questions: (a) Is there a "shift" to active nanostructures? (b) How can we characterize the prototypical areas into which active nanostructures may emerge? We build upon the NSF definition of active nanostructures to develop a research publication search strategy, with a particular intent to distinguish between passive and active nanotechnologies. We perform bibliometric analyses and describe the main publication trends from 1995 to 2008. We then describe the prototypes of research that emerge based on reading the abstracts and review papers encountered in our search. Preliminary results suggest that there is a sharp rise in active nanostructures publications in 2006, and this rise is maintained in 2007 and through to early 2008. We present a typology that can be used to describe the kind of active nanostructures that may be commercialized and regulated in the future.

  6. Experience with the shift technical advisor position

    SciTech Connect

    Melber, B.D.; Olson, J.; Schreiber, R.E.; Winges, L.

    1984-03-01

    The provision of engineering expertise on shift at commercial nuclear power plants has mainly taken the form of the Shift Technical Advisor (STA). This person, acting in a capacity that is part engineer and part operator, is expected to advise the operations crew in the event of an emergency and review plant operating experience during normal circumstances. The position was mandated by the Nuclear Regulatory Commission following the incident at Three Mile Island. This report expands on a growing body of knowledge regarding the effectiveness of the STA. The new data presented here come from interviews with plant personnel and utility officials from nine sites. Researchers from the Pacific Northwest Laboratory (PNL) interviewed plant personnel, including the STA and immediate management, the shift supervisor and management, the training department, and ancillary staff, all of whom affect the intended performance of the STA. The conclusions of the report are that the design of the STA position results in limited contribution during emergencies; more comprehensive ways should be sought to provide the variety and specificity of engineering expertise needed during such times.

  7. Stereoscopic watermarking by horizontal noise mean shifting

    NASA Astrophysics Data System (ADS)

    Lee, Ji-Won; Kim, Hee-Dong; Choi, Hak-Yeol; Choi, Sung-Hee; Lee, Heung-Kyu

    2012-03-01

    Depth-image-based rendering (DIBR) is a method to represent a stereoscopic content. The DIBR consists of a monoscopic center view and an associated per-pixel depth map. Using these two components and given depth condition from a user, the DIBR renders left and right views. The advantages of DIBR are numerous. The user can choose not only the monoscopic or stereoscopic view selectively, but also the depth condition what he prefers when he watches a stereoscopic content. However, in the view of copyright protection, since not only the center view but also each left or right view can be used as a monoscopic content when they are illegally distributed, the watermark signal which is embedded in the center view must have an ability to protect the respective three views. In this study, we solve this problem by exploiting the horizontal noise mean shifting (HNMS) technique. We exploit the fact that the objects in the view are shifted only to horizontal way when the center view renders to the left and right views. Using this fact, the proposed stereoscopic watermarking scheme moves the mean of horizontal noise histogram which is invariant to horizontal shifting, and we achieve good performance as shown in the experimental results.

  8. Concatenated shift registers generating maximally spaced phase shifts of PN-sequences

    NASA Technical Reports Server (NTRS)

    Hurd, W. J.; Welch, L. R.

    1977-01-01

    A large class of linearly concatenated shift registers is shown to generate approximately maximally spaced phase shifts of pn-sequences, for use in pseudorandom number generation. A constructive method is presented for finding members of this class, for almost all degrees for which primitive trinomials exist. The sequences which result are not normally characterized by trinomial recursions, which is desirable since trinomial sequences can have some undesirable randomness properties.

  9. Phase-shifting error and its elimination in phase-shifting digital holography.

    PubMed

    Guo, Cheng-Shan; Zhang, Li; Wang, Hui-Tian; Liao, Jun; Zhu, Y Y

    2002-10-01

    We investigate the influence of phase-shifting error on the quality of the reconstructed image in digital holography and propose a method of error elimination for a perfect image. In this method the summation of the intensity bit errors of the reconstructed image is taken as an evaluation function for an iterative algorithm to find the exact phase-shifting value. The feasibility of this method is demonstrated by computer simulation.

  10. The invisibilization of health promotion in Australian public health initiatives.

    PubMed

    O'Hara, Lily; Taylor, Jane; Barnes, Margaret

    2016-07-19

    The field of health promotion has arguably shifted over the past thirty years from being socially proactive to biomedically defensive. In many countries this has been accompanied by a gradual decline, or in some cases the almost complete removal of health promotion designated positions within Government health departments. The language or discourse used to describe the practice and discipline of health promotion is reflective of such changes. In this study, critical discourse analysis was used to determine the representation of health promotion as a practice and a discipline within 10 Australian Government weight-related public health initiatives. The analysis revealed the invisibilization of critical health promotion in favour of an agenda described as 'preventive health'. This was achieved primarily through the textual practices of overlexicalization and lexical suppression. Excluding document titles, there were 437 uses of the terms health promotion, illness prevention, disease prevention, preventive health, preventative health in the documents analysed. The term 'health promotion' was used sparingly (16% of total terms), and in many instances was coupled with the term 'illness prevention'. Conversely, the terms 'preventive health' and 'preventative health' were used extensively, and primarily used alone. The progressive invisibilization of critical health promotion has implications for the perceptions and practice of those identifying as health promotion professionals and for people with whom we work to address the social and structural determinants of health and wellbeing. Language matters, and the language and intent of critical health promotion will struggle to survive if its speakers are professionally unidentifiable or invisible.

  11. Absolute surface metrology with a phase-shifting interferometer for incommensurate transverse spatial shifts.

    PubMed

    Bloemhof, E E

    2014-02-10

    We consider the detailed implementation and practical utility of a novel absolute optical metrology scheme recently proposed for use with a phase-shifting interferometer (PSI). This scheme extracts absolute phase differences between points on the surface of the optic under test by differencing phase maps made with slightly different transverse spatial shifts of that optic. These absolute phase (or height) differences, which for single-pixel shifts are automatically obtained in the well-known Hudgin geometry, yield the underlying absolute surface map by standard wavefront reconstruction techniques. The PSI by itself maps surface height only relative to that of a separate reference optic known or assumed to be flat. In practice, even relatively high-quality (and expensive) transmission flats or spheres used to reference a PSI are flat or spherical only to a few dozen nanometers peak to valley (P-V) over typical 4 in. apertures. The new technique for removing the effects of the reference surface is in principle accurate as well as simple, and may represent a significant advance in optical metrology. Here it is shown that transverse shifts need not match the pixel size; somewhat counterintuitively, the single-pixel spatial resolution of the PSI is retained even when transverse shifts are much coarser. Practical considerations for shifts not necessarily commensurate with pixel size, and broader applications, are discussed.

  12. Regime Shifts in the Anthropocene: Drivers, Risks, and Resilience

    PubMed Central

    Rocha, Juan Carlos; Peterson, Garry D.; Biggs, Reinette

    2015-01-01

    Many ecosystems can experience regime shifts: surprising, large and persistent changes in the function and structure of ecosystems. Assessing whether continued global change will lead to further regime shifts, or has the potential to trigger cascading regime shifts has been a central question in global change policy. Addressing this issue has, however, been hampered by the focus of regime shift research on specific cases and types of regime shifts. To systematically assess the global risk of regime shifts we conducted a comparative analysis of 25 generic types of regime shifts across marine, terrestrial and polar systems; identifying their drivers, and impacts on ecosystem services. Our results show that the drivers of regime shifts are diverse and co-occur strongly, which suggests that continued global change can be expected to synchronously increase the risk of multiple regime shifts. Furthermore, many regime shift drivers are related to climate change and food production, whose links to the continued expansion of human activities makes them difficult to limit. Because many regime shifts can amplify the drivers of other regime shifts, continued global change can also be expected to increase the risk of cascading regime shifts. Nevertheless, the variety of scales at which regime shift drivers operate provides opportunities for reducing the risk of many types of regime shifts by addressing local or regional drivers, even in the absence of rapid reduction of global drivers. PMID:26267896

  13. Regime shifts in the anthropocene: drivers, risks, and resilience.

    PubMed

    Rocha, Juan Carlos; Peterson, Garry D; Biggs, Reinette

    2015-01-01

    Many ecosystems can experience regime shifts: surprising, large and persistent changes in the function and structure of ecosystems. Assessing whether continued global change will lead to further regime shifts, or has the potential to trigger cascading regime shifts has been a central question in global change policy. Addressing this issue has, however, been hampered by the focus of regime shift research on specific cases and types of regime shifts. To systematically assess the global risk of regime shifts we conducted a comparative analysis of 25 generic types of regime shifts across marine, terrestrial and polar systems; identifying their drivers, and impacts on ecosystem services. Our results show that the drivers of regime shifts are diverse and co-occur strongly, which suggests that continued global change can be expected to synchronously increase the risk of multiple regime shifts. Furthermore, many regime shift drivers are related to climate change and food production, whose links to the continued expansion of human activities makes them difficult to limit. Because many regime shifts can amplify the drivers of other regime shifts, continued global change can also be expected to increase the risk of cascading regime shifts. Nevertheless, the variety of scales at which regime shift drivers operate provides opportunities for reducing the risk of many types of regime shifts by addressing local or regional drivers, even in the absence of rapid reduction of global drivers.

  14. White matter shifts in MRI: Rehabilitating the Lorentz sphere in magnetic resonance

    NASA Astrophysics Data System (ADS)

    Barbara, Thomas M.

    2016-09-01

    A thorough exposition and analysis of the role of the Lorentz sphere in magnetic resonance is presented from the fundamental standpoint of macroscopic magnetostatics. The analysis will be useful to those interested in understanding susceptibility and chemical shift contributions to frequency shifts in magnetic resonance. Though the topic is mature, recent research on white matter shifts in the brain promotes the notion of replacing the Lorentz sphere with a generalized Lorentzian cylinder, and has put into question the long standing spherical approach when elongated structures are present. The cavity shape issue can be resolved by applying Helmholtz's theorem, which can be expressed in a differential and an integral formulation. The general validity of the Lorentz sphere for any situation is confirmed. Furthermore, a clear exposition of the "generalized approach" is offered, using the language of Lorentz's theory. With the rehabilitation of the Lorentz sphere settled, one must consider alternative contributions to white matter shifts and a likely candidate is the effect of molecular environment on chemical shifts.

  15. [Night shift work and prolactin as a breast cancer risk factor].

    PubMed

    Bukowska, Agnieszka; Pepłońska, Beata

    2013-01-01

    Prolactin - a hormone secreted in a circadian rhythm acts as a regulator of growth and development of the mammary glands. It has been observed that working at night increases breast cancer risk in women. Night shift work, probably carcinogenic to humans (Group 2A IARC), can disrupt a circadian rhythm, and thus potentially alter the rhythm of prolactin secretion. The aim of our work was to review epidemiological evidence on the association between prolactin and the risk of breast cancer and the influence of work at night on prolactin secretion. Search was done in the Medline database by keywords (shift work, work at night, risk of breast cancer and prolactin). 'The increased proliferation of breast cells activated by prolactin can promote the development of cancer. The results of the largest epidemiological prospective studies suggest the association between prolactin levels and the risk of breast cancer in women. So far, only seven studies have investigated the association between work at night and prolactin secretion. In three studies lower concentrations of prolactin have been observed in night shift workers. No relationship between the night shift work duration and prolactin level in women have been reported. Night shift work can modify the profile of prolactin secretion in night workers, probably decreasing the secretion of this hormone at night. It is therefore unlikely that prolactin plays an important role in the development of breast cancer in women working at night. This conclusion is based on the results of a few epidemiological studies.

  16. Weight science: evaluating the evidence for a paradigm shift.

    PubMed

    Bacon, Linda; Aphramor, Lucy

    2011-01-24

    Current guidelines recommend that "overweight" and "obese" individuals lose weight through engaging in lifestyle modification involving diet, exercise and other behavior change. This approach reliably induces short term weight loss, but the majority of individuals are unable to maintain weight loss over the long term and do not achieve the putative benefits of improved morbidity and mortality. Concern has arisen that this weight focus is not only ineffective at producing thinner, healthier bodies, but may also have unintended consequences, contributing to food and body preoccupation, repeated cycles of weight loss and regain, distraction from other personal health goals and wider health determinants, reduced self-esteem, eating disorders, other health decrement, and weight stigmatization and discrimination. This concern has drawn increased attention to the ethical implications of recommending treatment that may be ineffective or damaging. A growing trans-disciplinary movement called Health at Every Size (HAES) challenges the value of promoting weight loss and dieting behavior and argues for a shift in focus to weight-neutral outcomes. Randomized controlled clinical trials indicate that a HAES approach is associated with statistically and clinically relevant improvements in physiological measures (e.g., blood pressure, blood lipids), health behaviors (e.g., eating and activity habits, dietary quality), and psychosocial outcomes (such as self-esteem and body image), and that HAES achieves these health outcomes more successfully than weight loss treatment and without the contraindications associated with a weight focus. This paper evaluates the evidence and rationale that justifies shifting the health care paradigm from a conventional weight focus to HAES.

  17. Pterandra pyroidea: a case of pollination shift within Neotropical Malpighiaceae

    PubMed Central

    Cappellari, Simone C.; Haleem, Muhammad A.; Marsaioli, Anita J.; Tidon, Rosana; Simpson, Beryl B.

    2011-01-01

    Background and Aims Most Neotropical species of Malpighiaceae produce floral fatty oils in calyx glands to attract pollinating oil-collecting bees, which depend on this resource for reproduction. This specialized type of pollination system tends to be lost in members of the family that occur outside the geographic distribution (e.g. Africa) of Neotropical oil-collecting bees. This study focused on the pollination ecology, chemical ecology and reproductive biology of an oil flower species, Pterandra pyroidea (Malpighiaceae) from the Brazilian Cerrado. Populations of this species consist of plants with oil-secreting (glandular) flowers, plants with non-oil-secreting flowers (eglandular) or a mix of both plant types. This study specifically aims to clarify the role of eglandular morphs in this species. Methods Data on pollinators were recorded by in situ observations. Breeding system experiments were conducted by isolating inflorescences and by enzymatic reactions. Floral resources, pollen and floral oils offered by this species were analysed by staining and a combination of various spectroscopic methods. Key Results Eglandular flowers of P. pyroidea do not act as mimics of their oil-producing conspecifics to attract pollinators. Instead, both oil-producing and oil-free flowers depend on pollen-collecting bees for reproduction, and their main pollinators are bumble-bees. Floral oils produced by glandular flowers are less complex than those described in closely related genera. Conclusions Eglandular flowers represent a shift in the pollination system in which oil is being lost and pollen is becoming the main reward of P. pyroidea flowers. Pollination shifts of this kind have hitherto not been demonstrated empirically within Neotropical Malpighiaceae and this species exhibits an unusual transition from a specialized towards a generalized pollination system in an area considered the hotspot of oil-collecting bee diversity in the Neotropics. Transitions of this type

  18. Aligning work and circadian time in shift workers improves sleep and reduces circadian disruption.

    PubMed

    Vetter, Céline; Fischer, Dorothee; Matera, Joana L; Roenneberg, Till

    2015-03-30

    Sleep loss and circadian disruption-a state of misalignment between physiological functions and imposed sleep/wake behavior-supposedly play central roles in the etiology of shift work-related pathologies [1-4]. Circadian entrainment is, however, highly individual [5], resulting in different chronotypes [6, 7]. Chronotype in turn modulates the effects of working times: compared to late chronotypes, earlier ones sleep worse and shorter and show higher levels of circadian misalignment during night shifts, while late types experience more sleep and circadian disruption than early types when working morning shifts [8]. To promote sleep and reduce the mismatch between circadian and working time, we implemented a chronotype-adjusted (CTA) shift schedule in a factory. We abolished the most strenuous shifts for extreme chronotypes (i.e., mornings for late chronotypes, nights for early ones) and examined whether sleep duration and quality, social jetlag [9, 10], wellbeing, subjective stress perception, and satisfaction with leisure time improved in this schedule. Intermediate chronotypes (quartiles 2 and 3) served as a control group, still working morning (6:00-14:00), evening (14:00-22:00), and night (22:00-6:00) shifts, with two strenuous shifts (out of twelve per month) replaced by evening ones. We observed a significant increase of self-reported sleep duration and quality, along with increased wellbeing ratings on workdays among extreme chronotypes. The CTA schedule reduced overall social jetlag by 1 hr, did not alter stress levels, and increased satisfaction with leisure time (early types only). Chronotype-based schedules thus can reduce circadian disruption and improve sleep; potential long-term effects on health and economic indicators need to be elucidated in future studies.

  19. Ecohydrology by thinking outside the bog: Shifting paradigms in an era of shifting peatland ecosystems

    NASA Astrophysics Data System (ADS)

    Waddington, James; Moore, Paul

    2016-04-01

    Large shifts in vegetation distributions are occurring worldwide and at unprecedented rates. The most extreme of these regime shifts are expected to occur at ecosystem boundaries of both semi-arid and semi-humid landscapes. Despite extensive hydrological research on the interactions between water and semi-arid ecosystems, research in peatlands on the wet end of ecosystem continuum has been "bogged down" (pun fully intended) by the traditional conceptual models (paradigms?) of peatland hydrology and ecology. The consequences of this "thinking" are large given that northern peatlands provide important global and regional ecosystem services (carbon storage, water storage, and biodiversity). This is especially true because peatlands face increases in the severity, areal extent, and frequency of climate-mediated (e.g., wildfire, drought) and land-use change (e.g., drainage, flooding, and mining) disturbances placing the future security of these critical ecosystem services in doubt. We use the word doubt because while numerical modelling studies predict peatland regime shifts and the demise of global peat stocks, there is growing evidence that peatlands are self-regulating ecosystems dominated by negative ecohydrological feedbacks that stabilize the aforementioned ecosystem services through high ecosystem resilience to disturbance. This raises several important hydrological questions? "Is there field evidence of peatland regime shifts? If so, what are the potential impacts of these shifts on water resources and watershed management? If not, are researchers actually looking in the right places (or times)? In this presentation we explore the need for a "thinking outside the bog" in order to understand the ecohydrological consequences of transformative landscape change caused by peatland regime shifts. With reference to over two decades of field research, recent advances with our Peatland Hydrological Impacts model and recent research examining primary peat formation, we

  20. Pressure Shift and Gravitational RedShift of Balmer Lines in White Dwarfs: Rediscussion

    NASA Astrophysics Data System (ADS)

    Halenka, Jacek; Olchawa, Wieslaw; Madej, Jerzy; Grabowski, Boleslaw

    2015-08-01

    The Stark-induced shift and asymmetry, the so-called pressure shift (PS) of Hα and Hβ Balmer lines in spectra of DA white dwarfs (WDs), have been examined in detail as masking effects in measurements of the gravitational redshift in WDs. The results are compared with our earlier ones from a quarter of a century ago. In these earlier papers, the standard, symmetrical Stark line profiles, as a dominant constituent of the Balmer line profiles but shifted as a whole by the PS effect, were applied to all spectrally active layers of the WD atmosphere. At present, in each of the WD layers, the Stark line profiles (especially of Hβ) are inherently asymmetrical and shifted due to the effects of strong inhomogeneity of the perturbing fields in plasma. To calculate the Stark line profiles in successive layers of the WD atmosphere we used the modified Full Computer Simulation Method, able to take adequately into account the complexity of local elementary quantum processes in plasma. In the case of the Hα line, the present value of Stark-induced shift of the synthetic Hα line profile is about half the previous one and it is negligible in comparison with the gravitational redshift. In the case of the Hβ line, the present value of Stark-induced shift of the synthetic Hβ line profile is about twice the previous one. The source of this extra shift is the asymmetry of Hβ peaks. In memory of Jan Jerzy Kubikowski (1927-1968)—one of the pioneers of plasma in astrophysics.

  1. Drought-induced vegetation shifts in terrestrial ecosystems: The key role of regeneration dynamics

    NASA Astrophysics Data System (ADS)

    Martínez-Vilalta, Jordi; Lloret, Francisco

    2016-09-01

    Ongoing climate change is modifying climatic conditions worldwide, with a trend towards drier conditions in most regions. Vegetation will respond to these changes, eventually adjusting to the new climate. It is unclear, however, how close different ecosystems are to climate-related tipping points and, thus, how dramatic these vegetation changes will be in the short- to mid-term, given the existence of strong stabilizing processes. Here, we review the published evidence for recent drought-induced vegetation shifts worldwide, addressing the following questions: (i) what are the necessary conditions for vegetation shifts to occur? (ii) How much evidence of drought-induced vegetation shifts do we have at present and where are they occurring? (iii) What are the main processes that favor/oppose the occurrence of shifts at different ecological scales? (iv) What are the complications in detecting and attributing drought-induced vegetation shifts? (v) What ecological factors can interact with drought to promote shifts or stability? We propose a demographic framework to classify the likely outcome of instances of drought-induced mortality, based upon the survival of adults of potential replacement species and the regeneration of both formerly dominant affected species and potential replacement species. Out of 35 selected case studies only eight were clearly consistent with the occurrence of a vegetation shift (species or biome shift), whereas three corresponded to self-replacements in which the affected, formerly dominant species was able to regenerate after suffering drought-induced mortality. The other 24 cases were classified as uncertain, either due to lack of information or, more commonly, because the initially affected and potential replacement species all showed similar levels of regeneration after the mortality event. Overall, potential vegetation transitions were consistent with more drought-resistant species replacing less resistant ones. However, almost half (44

  2. 77 FR 47820 - Invention Promoters/Promotion Firms Complaints

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... United States Patent and Trademark Office Invention Promoters/Promotion Firms Complaints ACTION: Proposed... participate in any legal proceedings against invention promoters or promotion firms. Complaints submitted to... promotion firm, explain the basis for the complaint, and include the signature of the complainant....

  3. Phase-Shifting-Free Interferometric Cryptosystem

    NASA Astrophysics Data System (ADS)

    Li, Tuo; Shi, Yi-Shi

    2017-03-01

    Not Available Supported by the National Natural Science Foundation of China under Grant No 61575197, the K. C. Wong Education Foundation, the Fusion Foundation of Research and Education of Chinese Academy of Sciences, and the Youth Innovation Promotion Association of Chinese Academy of Sciences.

  4. Teacher Management and Educational Reforms: Paradigm Shifts

    ERIC Educational Resources Information Center

    Cheng, Yin Cheong

    2009-01-01

    In the past 15 years, numerous reforms and initiatives in many countries in the Asia-Pacific region have aimed to change education and promote new learning to prepare the new generation for the future. Unfortunately, despite good intentions and huge investments of resources, many of these reforms have been found to be ineffective and…

  5. Intrinsic Wavelength Shifts in Stellar Spectra

    NASA Astrophysics Data System (ADS)

    Dravins, D.; Lindegren, L.; Ludwig, H.-G.; Madsen, S.

    2004-12-01

    Wavelengths of stellar spectral lines do not have the precise values `naively' expected from laboratory wavelengths merely Doppler-shifted by stellar radial motion. Slight displacements may originate as convective shifts (correlated velocity and brightness patterns in the photosphere), as gravitational redshifts, or perhaps be induced by wave motions. Intrinsic lineshifts thus reveal stellar surface structure, while possible periodic changes (during a stellar activity cycle, say) need to be segregated from variability induced by orbiting exoplanets. Absolute lineshifts can now be studied also in some stars other than the Sun, thanks to astrometric determinations of stellar radial motion. Comparisons between spectroscopic apparent radial velocities and astrometrically determined radial motions reveal greater spectral blueshifts in F-type stars than in the Sun (as theoretically expected from their more vigorous convection), further increasing in A-type stars (possibly due to atmospheric shockwaves). Solar spectral atlases, and high-resolution spectra (from UVES on ESO VLT) of a dozen solar-type stars are being surveyed for `unblended' photospheric lines of most atomic species with accurate laboratory wavelengths available. One aim is to understand the ultimate information content of stellar spectra, and in what detail it will be feasible to verify models of stellar atmospheric hydrodynamics. These may predict line asymmetries (bisectors) and shifts for widely different classes of lines, but there will not result any comparison with observations if such lines do not exist in real spectra. An expected near-future development in stellar physics is spatially resolved spectroscopy across stellar disks, enabled by optical interferometry and adaptive optics on very large telescopes. Stellar surface structure manifests itself in the center-to-limb wavelength changes along a stellar diameter, and their spatially resolved time variability, diagnostics which already now can be

  6. Green binary and phase shifting mask

    NASA Astrophysics Data System (ADS)

    Shy, S. L.; Hong, Chao-Sin; Wu, Cheng-San; Chen, S. J.; Wu, Hung-Yu; Ting, Yung-Chiang

    2009-12-01

    SixNy/Ni thin film green mask blanks were developed , and are now going to be used to replace general chromium film used for binary mask as well as to replace molydium silicide embedded material for AttPSM for I-line (365 nm), KrF (248 nm), ArF (193 nm) and Contact/Proximity lithography. A bilayer structure of a 1 nm thick opaque, conductive nickel layer and a SixNy layer is proposed for binary and phase-shifting mask. With the good controlling of plasma CVD of SixNy under silane (50 sccm), ammonia (5 sccm) and nitrogen (100 sccm), the pressure is 250 mTorr. and RF frequency 13.56 MHz and power 50 W. SixNy has enough deposition latitude to meet the requirements as an embedded layer for required phase shift 180 degree, and the T% in 193, 248 and 365 nm can be adjusted between 2% to 20% for binary and phase shifting mask usage. Ni can be deposited by E-gun, its sheet resistance Rs is less than 1.435 kΩ/square. Jeol e-beam system and I-line stepper are used to evaluate these thin film green mask blanks, feature size less than 200 nm half pitch pattern and 0.558 μm pitch contact hole can be printed. Transmission spectrums of various thickness of SixNy film are inspected by using UV spectrometer and FTIR. Optical constants of the SixNy film are measured by n & k meter and surface roughness is inspected by using Atomic Force Microscope (AFM).

  7. Cost-shifting in the current medical environment

    NASA Astrophysics Data System (ADS)

    Gruber, William H.

    1994-12-01

    `Cost shifting' occurs when there is not a fair or accurate match of the payment and use of medical services. A common `cost shifting' occurs when an insured patient is charged more to cover free services provided to an uninsured patient. This paper documents the multiple negative consequences of the many categories of cost shifting, reviews forces which are leading both to an increase and decrease in the magnitude of cost shifting, and evaluates the consequences of cost shifting on the goals of U.S. health care reform and investment in medical technology. Policy to minimize the negative consequences of cost shifting is recommended.

  8. How orbital angular momentum affects beam shifts in optical reflection

    SciTech Connect

    Merano, M.; Hermosa, N.; Woerdman, J. P.; Aiello, A.

    2010-08-15

    It is well known that reflection of a Gaussian light beam (TEM{sub 00}) by a planar dielectric interface leads to four beam shifts when compared to the geometrical-optics prediction. These are the spatial Goos-Haenchen (GH) shift, the angular GH shift, the spatial Imbert-Fedorov (IF) shift, and the angular IF shift. We report here, theoretically and experimentally, that endowing the beam with orbital angular momentum leads to coupling of these four shifts; this is described by a 4x4 mixing matrix.

  9. Goos-Hänchen shifts in harmonic generation from metals.

    PubMed

    Yallapragada, V J; Gopal, Achanta Venu; Agarwal, G S

    2013-05-06

    We present the first calculation of the Goos-Hänchen shifts in the context of the nonlinear generation of fields. We specifically concentrate on shifts of second harmonic generated at metallic surfaces. At metallic surfaces the second harmonic primarily arises from discontinuities of the field at surfaces which not only result in large harmonic generation but also in significant Goos-Hänchen shifts of the generated second harmonic. Our results can be extended to other shifts like angular shifts and Fedorov-Imbert shifts.

  10. Pendulum Shifts, Context, Error, and Personal Accountability

    SciTech Connect

    Harold Blackman; Oren Hester

    2011-09-01

    This paper describes a series of tools that were developed to achieve a balance in under-standing LOWs and the human component of events (including accountability) as the INL continues its shift to a learning culture where people report, are accountable and interested in making a positive difference - and want to report because information is handled correctly and the result benefits both the reporting individual and the organization. We present our model for understanding these interrelationships; the initiatives that were undertaken to improve overall performance.

  11. Higher-order phase shift reconstruction approach

    SciTech Connect

    Cong Wenxiang; Wang Ge

    2010-10-15

    Purpose: Biological soft tissues encountered in clinical and preclinical imaging mainly consists of atoms of light elements with low atomic numbers and their elemental composition is nearly uniform with little density variation. Hence, x-ray attenuation contrast is relatively poor and cannot achieve satisfactory sensitivity and specificity. In contrast, x-ray phase-contrast provides a new mechanism for soft tissue imaging. The x-ray phase shift of soft tissues is about a thousand times greater than the x-ray absorption over the diagnostic x-ray energy range, yielding a higher signal-to-noise ratio than the attenuation contrast counterpart. Thus, phase-contrast imaging is a promising technique to reveal detailed structural variation in soft tissues, offering a high contrast resolution between healthy and malignant tissues. Here the authors develop a novel phase retrieval method to reconstruct the phase image on the object plane from the intensity measurements. The reconstructed phase image is a projection of the phase shift induced by an object and serves as input to reconstruct the 3D refractive index distribution inside the object using a tomographic reconstruction algorithm. Such x-ray refractive index images can reveal structural features in soft tissues, with excellent resolution differentiating healthy and malignant tissues. Methods: A novel phase retrieval approach is proposed to reconstruct an x-ray phase image of an object based on the paraxial Fresnel-Kirchhoff diffraction theory. A primary advantage of the authors' approach is higher-order accuracy over that with the conventional linear approximation models, relaxing the current restriction of slow phase variation. The nonlinear terms in the autocorrelation equation of the Fresnel diffraction pattern are eliminated using intensity images measured at different distances in the Fresnel diffraction region, simplifying the phase reconstruction to a linear inverse problem. Numerical experiments are performed

  12. Echelle Blaze Shift vs. MSM Monthly Offset

    NASA Astrophysics Data System (ADS)

    Valenti, Jeff

    2002-07-01

    In the near future, monthly MSM offsets will probably be disabled for STIS echelle gratings, alleviating to some extent calibration problems associated with the monthly offsets. The data from this program will be used to improve empirical and optical models relating wavelength and blaze function shifts. These models will in turn be used to improve the calibration of archival echelle data obtained while monthly MSM offsets were enabled. The flux standard HZ43 will be observed with the E230H echelle grating at a central wavelength of 2513 Angstroms. Five exposures will be obtained, each with a different monthly offset applied to the Mode Select Mechanism {MSM}.

  13. A partial differential equation for pseudocontact shift.

    PubMed

    Charnock, G T P; Kuprov, Ilya

    2014-10-07

    It is demonstrated that pseudocontact shift (PCS), viewed as a scalar or a tensor field in three dimensions, obeys an elliptic partial differential equation with a source term that depends on the Hessian of the unpaired electron probability density. The equation enables straightforward PCS prediction and analysis in systems with delocalized unpaired electrons, particularly for the nuclei located in their immediate vicinity. It is also shown that the probability density of the unpaired electron may be extracted, using a regularization procedure, from PCS data.

  14. Ambiguity produces attention shifts in category learning.

    PubMed

    Vadillo, Miguel A; Orgaz, Cristina; Luque, David; Nelson, James Byron

    2016-04-01

    It has been suggested that people and nonhuman animals protect their knowledge from interference by shifting attention toward the context when presented with information that contradicts their previous beliefs. Despite that suggestion, no studies have directly measured changes in attention while participants are exposed to an interference treatment. In the present experiments, we adapted a dot-probe task to track participants' attention to cues and contexts while they were completing a simple category learning task. The results support the hypothesis that interference produces a change in the allocation of attention to cues and contexts.

  15. Nonrelativistic Lamb shift for muonic molecules

    NASA Astrophysics Data System (ADS)

    Bukowski, Robert; Jeziorski, Bogumil

    1993-03-01

    A recently developed formula [R. Bukowski and B. Jeziorski, Phys. Rev. A46 (1992) 5437]. has been applied to estimate the soft-photon Lamb shift contribution to the energies of the muonic molecules ppμ, ddμ, ttμ, pdμ, ptμ and dtμ. The corresponding corrections to the dissociation energies for the excited P states of ddμ and dtμ have been found to be almost identical and equal to 0.048 meV. The magnitude of this stabilizing effect is too small to affect seriously the formation rates predictions.

  16. Resonance-shifting luminescent solar concentrators

    DOEpatents

    Giebink, Noel Christopher; Wiederrecht, Gary P; Wasielewski, Michael R

    2014-09-23

    An optical system and method to overcome luminescent solar concentrator inefficiencies by resonance-shifting, in which sharply directed emission from a bi-layer cavity into a glass substrate returns to interact with the cavity off-resonance at each subsequent reflection, significantly reducing reabsorption loss en route to the edges. In one embodiment, the system comprises a luminescent solar concentrator comprising a transparent substrate, a luminescent film having a variable thickness; and a low refractive index layer disposed between the transparent substrate and the luminescent film.

  17. Ambiguity produces attention shifts in category learning

    PubMed Central

    Orgaz, Cristina; Luque, David; Nelson, James Byron

    2016-01-01

    It has been suggested that people and nonhuman animals protect their knowledge from interference by shifting attention toward the context when presented with information that contradicts their previous beliefs. Despite that suggestion, no studies have directly measured changes in attention while participants are exposed to an interference treatment. In the present experiments, we adapted a dot-probe task to track participants’ attention to cues and contexts while they were completing a simple category learning task. The results support the hypothesis that interference produces a change in the allocation of attention to cues and contexts. PMID:26980780

  18. Solar Doppler shifts - Sources of continuous spectra

    NASA Technical Reports Server (NTRS)

    Duvall, T. L., Jr.; Harvey, J. W.

    1986-01-01

    Oscillation observations can be used to study nonoscillatory solar phenomena that exhibit Doppler shifts. The paper discusses several effects of these phenomena and their associated temporal and spatial power spectra: (1) they limit the signal-to-noise ratio and sometimes detectability of oscillation modes; (2) there is the potential for better understanding and/or detection of solar phenomena; (3) large-scale convection may spatially modulate oscillation modes, leading to a continuous background spectrum; and (4) in regions of the spectrum where the resolution to separate modes is lacking one can determine upper limits for the integrated effects of modes.

  19. In defence of the right shift theory.

    PubMed

    Annett, M

    1996-02-01

    The right shift (RS) theory of a gene for left-cerebral dominance which increases the probability of right-handedness is outlined, together with two proposed alternatives, the 1985a genetic theory of McManus and the 1993 developmental instability theory of Yeo and Gangestad. Similarities and differences among the three theories are reviewed. Both of the genetic theories can predict the distribution of handedness in families and in twins more efficiently than the developmental instability theory, and the RS theory better than the McManus theory.

  20. A tentative explanation of cosmological red shift

    NASA Technical Reports Server (NTRS)

    Chang, T.; Torr, D. G.

    1990-01-01

    The authors suggest a possible alternative explanation of cosmological red shift. They consider that there exists a background field in the universe, and that light (the photon) has an extremely weak interaction with this background, and as result, experiences an energy loss. By analogy with damped oscillations, the authors introduce a dumping term with the first derivative with respect to time in the wave equation. The solution yields a linearly reduced frequency of the light with travel distance. The purpose of this exercise is to demonstrate how a simple alternative interpretation of the Hubble relation can be generated.

  1. Differential-phase-shift quantum secret sharing.

    PubMed

    Inoue, K; Ohashi, T; Kukita, T; Watanebe, K; Hayashi, S; Honjo, T; Takesue, H

    2008-09-29

    A quantum secret sharing (QSS) protocol based on a differential-phase-shift scheme is proposed, which quantum mechanically provides a full secret key to one party and partial keys to two other parties. A weak coherent pulse train is utilized instead of individual photons as in conventional schemes. Compared with previous QSS protocols, the present one features a simple setup, is suitable for fiber transmission, and offers the possibility for a high key creation rate. An experiment is also carried out to demonstrate the operation.

  2. Automatic Detection of Attention Shifts in Infancy: Eye Tracking in the Fixation Shift Paradigm.

    PubMed

    Kulke, Louisa; Atkinson, Janette; Braddick, Oliver

    2015-01-01

    This study measured changes in switches of attention between 1 and 9 months of age in 67 typically developing infants. Remote eye-tracking (Tobii X120) was used to measure saccadic latencies, related to switches of fixation, as a measure of shifts of attention, from a central stimulus to a peripheral visual target, measured in the Fixation Shift Paradigm. Fixation shifts occur later if the central fixation stimulus stays visible when the peripheral target appears (competition condition), than if the central stimulus disappears as the peripheral target appears (non-competition condition). This difference decreases with age. Our results show significantly faster disengagement in infants over 4 months than in the younger group, and provide more precise measures of fixation shifts, than behavioural observation with the same paradigm. Reduced saccadic latencies in the course of a test session indicate a novel learning effect. The Fixation Shift Paradigm combined with remote eye-tracking measures showed improved temporal and spatial accuracy compared to direct observation by a trained observer, and allowed an increased number of trials in a short testing time. This makes it an infant-friendly non-invasive procedure, involving minimal observational training, suitable for use in future studies of clinical populations to detect early attentional abnormalities in the first few months of life.

  3. NMR characterization of cellulose acetate: chemical shift assignments, substituent effects, and chemical shift additivity.

    PubMed

    Kono, Hiroyuki; Hashimoto, Hisaho; Shimizu, Yuuichi

    2015-03-15

    A series of cellulose acetates (CA) with degrees of substitution (DS) ranging from 2.92-0.92 dissolved in dimethylsulfoxide (DMSO)-d6 and cellulose dissolved in tetrabutylammonium fluoride (TBAF)/DMSO-d6 were investigated by two-dimensional NMR spectroscopy. The NMR spectroscopic analysis allowed the determination of the (1)H and (13)C NMR chemical shifts of the eight anhydroglucose units (AGUs) that contain CA: 2,3,6-tri-, 2,3-di-, 2,6-di-, 3,6-di-, 2-mono-, 3-mono-, 6-mono-, and unacetylated AGUs. A comparative analysis of the chemical shift data revealed the substituent effect of acetyl groups at the 2-, 3-, and 6-positions on the (1)H and (13)C nuclei in the same AGU. In addition, chemical shift additivity could be applied to the (1)H and (13)C chemical shifts of CA because the chemical shifts of the diacetylated and triacetylated AGUs could be almost completely explained by the acetyl substituent effects at the 2-, 3-, and 6-positions.

  4. Novelty and Promotional Items

    EPA Pesticide Factsheets

    Small novelty or promotional products, primarily used for outreach and educational purposes, must effectively convey a message, and their purchase will only be allowed if the item will contribute to the accomplishment of the Agency's mission.

  5. Promoting "Global" Attitudes.

    ERIC Educational Resources Information Center

    Case, Roland

    1996-01-01

    Discusses and illustrates three ways to promote prosocial attitudes towards global issues among students. Includes classroom environments that reinforce desired attitudes; facilitating direct "emotional" experiences that influence attitudes; and engaging students in thoughtful deliberation about global issues. Offers illustrative…

  6. Pollen dispersal slows geographical range shift and accelerates ecological niche shift under climate change

    PubMed Central

    Aguilée, Robin; Raoul, Gaël; Rousset, François; Ronce, Ophélie

    2016-01-01

    Species may survive climate change by migrating to track favorable climates and/or adapting to different climates. Several quantitative genetics models predict that species escaping extinction will change their geographical distribution while keeping the same ecological niche. We introduce pollen dispersal in these models, which affects gene flow but not directly colonization. We show that plant populations may escape extinction because of both spatial range and ecological niche shifts. Exact analytical formulas predict that increasing pollen dispersal distance slows the expected spatial range shift and accelerates the ecological niche shift. There is an optimal distance of pollen dispersal, which maximizes the sustainable rate of climate change. These conclusions hold in simulations relaxing several strong assumptions of our analytical model. Our results imply that, for plants with long distance of pollen dispersal, models assuming niche conservatism may not accurately predict their future distribution under climate change. PMID:27621443

  7. Advantages of shift changeovers with meetings: ergonomic analysis of shift supervisors' activity in aircraft building.

    PubMed

    Le Bris, Valérie; Barthe, Béatrice; Marquié, Jean-Claude; Kerguelen, Alain; Aubert, Sophie; Bernadou, Bernadette

    2012-03-01

    Good shift changeovers contribute to ensuring continuity and reliability in shift work. In situations where production is not maintained 24 h a day, changeovers with meetings (SCM) between the two work teams (written plus oral face-to-face handovers) alternate with changeovers without meetings (SCnM; written handovers only). An ergonomic work analysis on an aircraft assembly line showed that (1) incoming and outgoing operators met during the overlap time allotted by the company, and (2) the content of the exchanges was richer for SCMs than for SCnMs. SCMs enabled the operators to pass on and process more aspects of their work than SCnMs did. SCMs also allowed incoming operators to validate their predictions, and enabled both outgoing and incoming operators to update their mental models and work together on peripheral aspects of the technical process over a greater time span. The findings highlight the importance of allowing overlap time in shift work.

  8. Edge technique for measurement of laser frequency shifts including the Doppler shift

    NASA Technical Reports Server (NTRS)

    Korb, Larry (Inventor)

    1991-01-01

    A method is disclosed for determining the frequency shift in a laser system by transmitting an outgoing laser beam. An incoming laser beam having a frequency shift is received. A first signal is acquired by transmitting a portion of the incoming laser beam to an energy monitor detector. A second signal is acquired by transmitting a portion of the incoming laser beam through an edge filter to an edge detector, which derives a first normalized signal which is proportional to the transmission of the edge filter at the frequency of the incoming laser beam. A second normalized signal is acquired which is proportional to the transmission of the edge filter at the frequency of the outgoing laser beam. The frequency shift is determined by processing the first and second normalized signals.

  9. Tachyons, Lamb shifts and superluminal chaos

    NASA Astrophysics Data System (ADS)

    Tomaschitz, R.

    2000-10-01

    An elementary account on the origins of cosmic chaos in an open and multiply connected universe is given; there is a finite region in the open 3-space in which the world-lines of galaxies are chaotic, and the mixing taking place in this chaotic nucleus of the universe provides a mechanism to create equidistribution. The galaxy background defines a distinguished frame of reference and a unique cosmic time order; in this context superluminal signal transfer is studied. Tachyons are described by a real Proca field with negative mass square, coupled to a current of subluminal matter. Estimates on tachyon mixing in the geometric optics limit are derived. The potential of a static point source in this field theory is a damped periodic function. We treat this tachyon potential as a perturbation of the Coulomb potential, and study its effects on energy levels in hydrogenic systems. By comparing the induced level shifts to high-precision Lamb shift measurements and QED calculations, we suggest a tachyon mass of 2.1 keV/c2 and estimate the tachyonic coupling strength to subluminal matter. The impact of the tachyon field on ground state hyperfine transitions in hydrogen and muonium is investigated. Bounds on atomic transition rates effected by tachyon radiation as well as estimates on the spectral energy density of a possible cosmic tachyon background radiation are derived.

  10. The Underlying Social Dynamics of Paradigm Shifts

    PubMed Central

    Claro, Francisco; Fuentes, Miguel Angel

    2015-01-01

    We develop here a multi-agent model of the creation of knowledge (scientific progress or technological evolution) within a community of researchers devoted to such endeavors. In the proposed model, agents learn in a physical-technological landscape, and weight is attached to both individual search and social influence. We find that the combination of these two forces together with random experimentation can account for both i) marginal change, that is, periods of normal science or refinements on the performance of a given technology (and in which the community stays in the neighborhood of the current paradigm); and ii) radical change, which takes the form of scientific paradigm shifts (or discontinuities in the structure of performance of a technology) that is observed as a swift migration of the knowledge community towards the new and superior paradigm. The efficiency of the search process is heavily dependent on the weight that agents posit on social influence. The occurrence of a paradigm shift becomes more likely when each member of the community attaches a small but positive weight to the experience of his/her peers. For this parameter region, nevertheless, a conservative force is exerted by the representatives of the current paradigm. However, social influence is not strong enough to seriously hamper individual discovery, and can act so as to empower successful individual pioneers who have conquered the new and superior paradigm. PMID:26418255

  11. Wright's shifting balance theory: an experimental study.

    PubMed

    Wade, M J; Goodnight, C J

    1991-08-30

    Experimental confirmation of Wright's shifting balance theory of evolution, one of the most comprehensive theories of adaptive evolution, is presented. The theory is regarded by many as a cornerstone of modern evolutionary thought, but there has been little direct empirical evidence supporting it. Some of its underlying assumptions are viewed as contradictory, and the existence and efficacy of the theory's fundamental adaptive process, interdemic selection, is the focus of controversy. Interdemic selection was imposed on large arrays of laboratory populations of the flour beetle Tribolium castaneum in the manner described by Wright: the differential dispersion of individuals from demes of high fitness into demes of low fitness. A significant increase in average fitness was observed in the experimental arrays when compared to control populations with equivalent but random migration rates. The response was not proportional to the selection differential: The largest response occurred with interdemic selection every two generations rather than every generation or every three generations. The results indicate that the interdemic phase of Wright's shifting balance theory can increase average fitness and suggest that gene interactions are involved in the observed response.

  12. Neural signals encoding shifts in beliefs

    PubMed Central

    Schwartenbeck, Philipp; FitzGerald, Thomas H.B.; Dolan, Ray

    2016-01-01

    Dopamine is implicated in a diverse range of cognitive functions including cognitive flexibility, task switching, signalling novel or unexpected stimuli as well as advance information. There is also longstanding line of thought that links dopamine with belief formation and, crucially, aberrant belief formation in psychosis. Integrating these strands of evidence would suggest that dopamine plays a central role in belief updating and more specifically in encoding of meaningful information content in observations. The precise nature of this relationship has remained unclear. To directly address this question we developed a paradigm that allowed us to decompose two distinct types of information content, information-theoretic surprise that reflects the unexpectedness of an observation, and epistemic value that induces shifts in beliefs or, more formally, Bayesian surprise. Using functional magnetic-resonance imaging in humans we show that dopamine-rich midbrain regions encode shifts in beliefs whereas surprise is encoded in prefrontal regions, including the pre-supplementary motor area and dorsal cingulate cortex. By linking putative dopaminergic activity to belief updating these data provide a link to false belief formation that characterises hyperdopaminergic states associated with idiopathic and drug induced psychosis. PMID:26520774

  13. Microstrip Antennas with Broadband Integrated Phase Shifting

    NASA Technical Reports Server (NTRS)

    Bernhard, Jennifer T.; Romanofsky, Robert R. (Technical Monitor)

    2001-01-01

    The goal of this research was to investigate the feasibility of using a spiral microstrip antenna that incorporates a thin ferroelectric layer to achieve both radiation and phase shifting. This material is placed between the conductive spiral antenna structure and the grounded substrate. Application of a DC bias between the two arms of the spiral antenna will change the effective permittivity of the radiating structure and the degree of coupling between contiguous spiral arms, therefore changing the phase of the RF signal transmitted or received by the antenna. This could eliminate the need for a separate phase shifter apart from the antenna structure. The potential benefits of such an antenna element compared to traditional phased array elements include: continuous, broadband phase shifting at the antenna, lower overall system losses, lighter, more efficient, and more compact phased arrays, and simpler control algorithms. Professor Jennifer Bernhard, graduate student Gregory Huff, and undergraduate student Brian Huang participated in this effort from March 1, 2000 to February 28, 2001. No inventions resulted from the research undertaken in this cooperative agreement.

  14. Language lateralization shifts with learning by adults.

    PubMed

    Plante, Elena; Almryde, Kyle; Patterson, Dianne K; Vance, Christopher J; Asbjørnsen, Arve E

    2015-05-01

    For the majority of the population, language is a left-hemisphere lateralized function. During childhood, a pattern of increasing left lateralization for language has been described in brain imaging studies, suggesting that this trait develops. This development could reflect change due to brain maturation or change due to skill acquisition, given that children acquire and refine language skills as they mature. We test the possibility that skill acquisition, independent of age-associated maturation can result in shifts in language lateralization in classic language cortex. We imaged adults exposed to an unfamiliar language during three successive fMRI scans. Participants were then asked to identify specific words embedded in Norwegian sentences. Exposure to these sentences, relative to complex tones, resulted in consistent activation in the left and right superior temporal gyrus. Activation in this region became increasingly left-lateralized with repeated exposure to the unfamiliar language. These results demonstrate that shifts in lateralization can be produced in the short term within a learning context, independent of maturation.

  15. Saturated Dispersive Extinction Theory of Red Shift

    NASA Astrophysics Data System (ADS)

    Wang, Ling Jun

    2012-03-01

    The Dispersive Extinction Theory (DET) proposed by WangfootnotetextWang, Ling Jun, Physics Essays, 18, No. 2, (2005). offers an alternative to the Big Bang. According to DET, the cosmic red shift is caused by the dispersive extinction of the star light during the propagation from the stars to the earth, instead of being caused by the Doppler shift due to the expansion of the universe.footnotetextHubble, E., Astrophys. J. 64, 321 (1926).^,footnotetextHubble, E., The Realm of the Nebulae, (Yale University Press, New Haven, 1936). DET allows an infinite, stable, non expanding universe, and is immune of the fundamental problems inherent to the Big Bang such as the horizon problem, the extreme violation of the conservation of mass, energy and charge, and the geocentric nature which violates the principle of relativity.footnotetextWang, Ling Jun, Physics Essays, 20, No. 2, (2007). The scenario dealt with in Reference (1) is a one in which the extinction by the space medium is not saturated. This work deals with a different scenario when the extinction is saturated. The saturated extinction causes limited energy loss, and the star light can travel a much greater distance than in the unsaturated scenario.

  16. Metabolic Shifts during Aging and Pathology

    PubMed Central

    Ma, Yina; Li, Ji

    2016-01-01

    The heart is a very special organ in the body and has a high requirement for metabolism due to its constant workload. As a consequence, to provide a consistent and sufficient energy a high steady-state demand of metabolism is required by the heart. When delicately balanced mechanisms are changed by physiological or pathophysiological conditions, the whole system’s homeostasis will be altered to a new balance, which contributes to the pathologic process. So it is no wonder that almost every heart disease is related to metabolic shift. Furthermore, aging is also found to be related to the reduction in mitochondrial function, insulin resistance, and dysregulated intracellular lipid metabolism. Adenosine monophosphate-activated protein kinase (AMPK) functions as an energy sensor to detect intracellular ATP/AMP ratio and plays a pivotal role in intracellular adaptation to energy stress. During different pathology (like myocardial ischemia and hypertension), the activation of cardiac AMPK appears to be essential for repairing cardiomyocyte’s function by accelerating ATP generation, attenuating ATP depletion, and protecting the myocardium against cardiac dysfunction and apoptosis. In this overview, we will talk about the normal heart’s metabolism, how metabolic shifts during aging and different pathologies, and how AMPK regulates metabolic changes during these conditions. PMID:25880509

  17. Shifting seasons, climate change and ecosystem consequences

    NASA Astrophysics Data System (ADS)

    Thackeray, Stephen; Henrys, Peter; Hemming, Deborah; Huntingford, Chris; Bell, James; Leech, David; Wanless, Sarah

    2014-05-01

    In recent decades, the seasonal timing of many biological events (e.g. flowering, breeding, migration) has shifted. These phenological changes are believed to be one of the most conspicuous biological indicators of climate change. Rates and directions of phenological change have differed markedly among species, potentially threatening the seasonal synchrony of key species interactions and ultimately ecosystem functioning. Differences in phenological change among-species at different trophic levels, and with respect to other broad species traits, are likely to be driven by variations in the climatic sensitivity of phenological events. However, as yet, inconsistencies in analytical methods have hampered broad-scale assessments of variation in climate sensitivity among taxonomic and functional groups of organisms. In this presentation, results will be presented from a current collaborative project (http://www.ceh.ac.uk/sci_programmes/shifting-seasons-uk.html) in which many UK long-term data sets are being integrated in order to assess relationships between temperature/precipitation, and the timing of seasonal events for a wide range of plants and animals. Our aim is to assess which organism groups (in which locations/habitats) are most sensitive to climate. Furthermore, the role of anthropogenic climate change as a driver of phenological change is being assessed.

  18. Theory of Lamb Shift in Muonic Hydrogen

    SciTech Connect

    Karshenboim, Savely G.; Korzinin, Evgeny Yu.; Shelyuto, Valery A.; Ivanov, Vladimir G.

    2015-09-15

    There has been for a while a large discrepancy between the values of the proton charge radius measured by the Lamb shift in muonic hydrogen and by other methods. It has already been clear that theory of muonic hydrogen is reliable at the level of this discrepancy and an error there cannot be a reason for the contradiction. Still the status of theory at the level of the uncertainty of the muonic-hydrogen experiment (which is two orders of magnitude below the discrepancy level) requires an additional clarification. Here, we revisit theory of the 2p − 2s Lamb shift in muonic hydrogen. We summarize all the theoretical contributions in order α{sup 5}m, including pure quantum electrodynamics (QED) ones as well as those which involve the proton-structure effects. Certain enhanced higher-order effects are also discussed. We basically confirm former QED calculations of other authors, present a review of recent calculations of the proton-structure effects, and treat self-consistently higher-order proton-finite-size corrections. We also overview theory of the 2p states. Eventually, we derive a value of the root-mean-square proton charge radius. It is found to be 0.840 29(55) fm, which is slightly different from that previously published in the literature (0.840 87(39) fm [Antognini et al., Science 339, 417 (2013)])

  19. The Underlying Social Dynamics of Paradigm Shifts.

    PubMed

    Rodriguez-Sickert, Carlos; Cosmelli, Diego; Claro, Francisco; Fuentes, Miguel Angel

    2015-01-01

    We develop here a multi-agent model of the creation of knowledge (scientific progress or technological evolution) within a community of researchers devoted to such endeavors. In the proposed model, agents learn in a physical-technological landscape, and weight is attached to both individual search and social influence. We find that the combination of these two forces together with random experimentation can account for both i) marginal change, that is, periods of normal science or refinements on the performance of a given technology (and in which the community stays in the neighborhood of the current paradigm); and ii) radical change, which takes the form of scientific paradigm shifts (or discontinuities in the structure of performance of a technology) that is observed as a swift migration of the knowledge community towards the new and superior paradigm. The efficiency of the search process is heavily dependent on the weight that agents posit on social influence. The occurrence of a paradigm shift becomes more likely when each member of the community attaches a small but positive weight to the experience of his/her peers. For this parameter region, nevertheless, a conservative force is exerted by the representatives of the current paradigm. However, social influence is not strong enough to seriously hamper individual discovery, and can act so as to empower successful individual pioneers who have conquered the new and superior paradigm.

  20. Inositol phosphates induce DAPI fluorescence shift.

    PubMed

    Kolozsvari, Bernadett; Parisi, Federica; Saiardi, Adolfo

    2014-06-15

    The polymer inorganic polyP (polyphosphate) and inositol phosphates, such as IP6 (inositol hexakisphosphate; also known as phytic acid), share many biophysical features. These similarities must be attributed to the phosphate groups present in these molecules. Given the ability of polyP to modify the excitation-emission spectra of DAPI we decided to investigate whether inositol phosphates possess the same property. We discovered that DAPI-IP6 complexes emit at approximately 550 nm when excited with light of wavelength 410-420 nm. IP5 (inositol pentakisphosphate) is also able to induce a similar shift in DAPI fluorescence. Conversely, IP3 (inositol trisphosphate) and IP4 (inositol tetrakisphosphate) are unable to shift DAPI fluorescence. We have employed this newly discovered feature of DAPI to study the enzymatic activity of the inositol polyphosphate multikinase and to monitor phytase phosphatase reactions. Finally, we used DAPI-IP6 fluorescence to determine the amount of IP6 in plant seeds. Using an IP6 standard curve this straight-forward analysis revealed that among the samples tested, borlotti beans possess the highest level of IP6 (9.4 mg/g of dry mass), whereas the Indian urad bean the lowest (3.2 mg/g of dry mass). The newly identified fluorescence properties of the DAPI-IP5 and DAPI-IP6 complexes allow the levels and enzymatic conversion of these two important messengers to be rapidly and reliably monitored.

  1. Testability and epistemic shifts in modern cosmology

    NASA Astrophysics Data System (ADS)

    Kragh, Helge

    2014-05-01

    During the last decade new developments in theoretical and speculative cosmology have reopened the old discussion of cosmology's scientific status and the more general question of the demarcation between science and non-science. The multiverse hypothesis, in particular, is central to this discussion and controversial because it seems to disagree with methodological and epistemic standards traditionally accepted in the physical sciences. But what are these standards and how sacrosanct are they? Does anthropic multiverse cosmology rest on evaluation criteria that conflict with and go beyond those ordinarily accepted, so that it constitutes an "epistemic shift" in fundamental physics? The paper offers a brief characterization of the modern multiverse and also refers to a few earlier attempts to introduce epistemic shifts in the science of the universe. It further discusses the several meanings of testability, addresses the question of falsifiability as a sine qua non for a theory being scientific, and briefly compares the situation in cosmology with the one in systematic biology. Multiverse theory is not generally falsifiable, which has led to proposals from some physicists to overrule not only Popperian standards but also other evaluation criteria of a philosophical nature. However, this is hardly possible and nor is it possible to get rid of explicit philosophical considerations in some other aspects of cosmological research, however advanced it becomes.

  2. Theory of Lamb Shift in Muonic Hydrogen

    NASA Astrophysics Data System (ADS)

    Karshenboim, Savely G.; Korzinin, Evgeny Yu.; Shelyuto, Valery A.; Ivanov, Vladimir G.

    2015-09-01

    There has been for a while a large discrepancy between the values of the proton charge radius measured by the Lamb shift in muonic hydrogen and by other methods. It has already been clear that theory of muonic hydrogen is reliable at the level of this discrepancy and an error there cannot be a reason for the contradiction. Still the status of theory at the level of the uncertainty of the muonic-hydrogen experiment (which is two orders of magnitude below the discrepancy level) requires an additional clarification. Here, we revisit theory of the 2p - 2s Lamb shift in muonic hydrogen. We summarize all the theoretical contributions in order α5m, including pure quantum electrodynamics (QED) ones as well as those which involve the proton-structure effects. Certain enhanced higher-order effects are also discussed. We basically confirm former QED calculations of other authors, present a review of recent calculations of the proton-structure effects, and treat self-consistently higher-order proton-finite-size corrections. We also overview theory of the 2p states. Eventually, we derive a value of the root-mean-square proton charge radius. It is found to be 0.840 29(55) fm, which is slightly different from that previously published in the literature (0.840 87(39) fm [Antognini et al., Science 339, 417 (2013)]).

  3. Language Lateralization Shifts with Learning by Adults

    PubMed Central

    Plante, Elena; Almryde, Kyle; Patterson, Dianne K.; Vance, Christopher J.; Asbjørnsen, Arve E.

    2014-01-01

    For the majority of the population, language is a left hemisphere lateralized function. During childhood, a pattern of increasing left lateralization for language has been described in brain imaging studies, suggesting this trait develops. This development could reflect change due to brain maturation or change due to skill acquisition, given that children acquire and refine language skills as they mature. We test the possibility that skill acquisition, independent of age-associated maturation can result in shifts in language lateralization in classic language cortex. We imaged adults exposed to unfamiliar language during three successive fMRI scans. Participants were then asked to identify specific words embedded in Norwegian sentences. Exposure to these sentences, relative to complex tones, resulted in consistent activation in the left and right superior temporal gyrus. Activation in this region became increasingly left lateralized with repeated exposure to the unfamiliar language. These results demonstrate that shifts in lateralization can be produced in the short-term within a learning context, independent of maturation. PMID:25285756

  4. [Shift- and Nightwork - a scientometric analysis].

    PubMed

    van Mark, Anke; Vitzthum, Karin; Höndorf, Franka; Kloss, Lisa; Quarcoo, David; Groneberg, David A

    2011-04-01

    Economic restructuring processes in Germany require changes within all social and health care systems regarding night shiftwork. The aim of this paper was to analyse research results referring to shift- and nightwork using scientometric methods. A total of 3092 items could be detected. A constant increase in the number of publications per year since 1977, especially since 1990' was obvious. One third of the research results, a total of 884 articles could be assigned to the USA. Great Britain could be identified with 365 articles and France with 244 published articles. Sleep, Ergonomics and Chronobiology International are the most prolific journals. The Swedish scientist Torbjörn Akerstedt is to this date the most acclaimed researcher referring to his issue. He has written 105 articles about shift- and nightwork. He is not only a most efficient author, but also has the highest h-index [30]. Self-citations and multiple co-authorships distort parameters like impact factor and h-index enormously and should be regarded from a critical point of view.

  5. Automated manual transmission shift sequence controller

    DOEpatents

    Lawrie, Robert E.; Reed, Richard G.; Rausen, David J.

    2000-02-01

    A powertrain system for a hybrid vehicle. The hybrid vehicle includes a heat engine, such as a diesel engine, and an electric machine, which operates as both, an electric motor and an alternator, to power the vehicle. The hybrid vehicle also includes a manual-style transmission configured to operate as an automatic transmission from the perspective of the driver. The engine and the electric machine drive an input shaft which in turn drives an output shaft of the transmission. In addition to driving the transmission, the electric machine regulates the speed of the input shaft in order to synchronize the input shaft during either an upshift or downshift of the transmission by either decreasing or increasing the speed of the input shaft. When decreasing the speed of the input shaft, the electric motor functions as an alternator to produce electrical energy which may be stored by a storage device. Operation of the transmission is controlled by a transmission controller which receives input signals and generates output signals to control shift and clutch motors to effect smooth launch, upshift shifts, and downshifts of the transmission, so that the transmission functions substantially as an automatic transmission from the perspective of the driver, while internally substantially functioning as a manual transmission.

  6. Damage detection using frequency shift path

    NASA Astrophysics Data System (ADS)

    Wang, Longqi; Lie, Seng Tjhen; Zhang, Yao

    2016-01-01

    This paper introduces a novel concept called FREquency Shift (FRESH) path to describe the dynamic behavior of structures with auxiliary mass. FRESH path combines the effects of frequency shifting and amplitude changing into one space curve, providing a tool for analyzing structure health status and properties. A damage index called FRESH curvature is then proposed to detect local stiffness reduction. FRESH curvature can be easily adapted for a particular problem since the sensitivity of the index can be adjusted by changing auxiliary mass or excitation power. An algorithm is proposed to adjust automatically the contribution from frequency and amplitude in the method. Because the extraction of FRESH path requires highly accurate frequency and amplitude estimators; therefore, a procedure based on discrete time Fourier transform is introduced to extract accurate frequency and amplitude with the time complexity of O (n log n), which is verified by simulation signals. Moreover, numerical examples with different damage sizes, severities and damping are presented to demonstrate the validity of the proposed damage index. In addition, applications of FRESH path on two steel beams with different damages are presented and the results show that the proposed method is valid and computational efficient.

  7. Red-Shifting versus Blue-Shifting Hydrogen Bonds: Perspective from Ab Initio Valence Bond Theory.

    PubMed

    Chang, Xin; Zhang, Yang; Weng, Xinzhen; Su, Peifeng; Wu, Wei; Mo, Yirong

    2016-05-05

    Both proper, red-shifting and improper, blue-shifting hydrogen bonds have been well-recognized with enormous experimental and computational studies. The current consensus is that there is no difference in nature between these two kinds of hydrogen bonds, where the electrostatic interaction dominates. Since most if not all the computational studies are based on molecular orbital theory, it would be interesting to gain insight into the hydrogen bonds with modern valence bond (VB) theory. In this work, we performed ab initio VBSCF computations on a series of hydrogen-bonding systems, where the sole hydrogen bond donor CF3H interacts with ten hydrogen bond acceptors Y (═NH2CH3, NH3, NH2Cl, OH(-), H2O, CH3OH, (CH3)2O, F(-), HF, or CH3F). This series includes four red-shifting and six blue-shifting hydrogen bonds. Consistent with existing findings in literature, VB-based energy decomposition analyses show that electrostatic interaction plays the dominating role and polarization plays the secondary role in all these hydrogen-bonding systems, and the charge transfer interaction, which denotes the hyperconjugation effect, contributes only slightly to the total interaction energy. As VB theory describes any real chemical bond in terms of pure covalent and ionic structures, our fragment interaction analysis reveals that with the approaching of a hydrogen bond acceptor Y, the covalent state of the F3C-H bond tends to blue-shift, due to the strong repulsion between the hydrogen atom and Y. In contrast, the ionic state F3C(-) H(+) leads to the red-shifting of the C-H vibrational frequency, owing to the attraction between the proton and Y. Thus, the relative weights of the covalent and ionic structures essentially determine the direction of frequency change. Indeed, we find the correlation between the structural weights and vibrational frequency changes.

  8. An advanced phase retrieval algorithm in N-step phase-shifting interferometry with unknown phase shifts

    PubMed Central

    Li, Jiaosheng; Zhong, Liyun; Liu, Shengde; Zhou, Yunfei; Xu, Jie; Tian, Jindong; Lu, Xiaoxu

    2017-01-01

    In phase-shifting interferometry with unknown phase shifts, a normalization and orthogonalization phase-shifting algorithm (NOPSA) is proposed to achieve phase retrieval. The background of interferogram is eliminated through using the orthogonality of complex sinusoidal function; and the influence of phase shifts deviation on accuracy of phase retrieval is avoided through both normalization and orthogonalization processing. Compared with the current algorithms with unknown phase shifts, the proposed algorithm reveals significantly faster computation speed, higher accuracy, better stability and non-sensitivity of phase shifts deviation. PMID:28290494

  9. An advanced phase retrieval algorithm in N-step phase-shifting interferometry with unknown phase shifts

    NASA Astrophysics Data System (ADS)

    Li, Jiaosheng; Zhong, Liyun; Liu, Shengde; Zhou, Yunfei; Xu, Jie; Tian, Jindong; Lu, Xiaoxu

    2017-03-01

    In phase-shifting interferometry with unknown phase shifts, a normalization and orthogonalization phase-shifting algorithm (NOPSA) is proposed to achieve phase retrieval. The background of interferogram is eliminated through using the orthogonality of complex sinusoidal function; and the influence of phase shifts deviation on accuracy of phase retrieval is avoided through both normalization and orthogonalization processing. Compared with the current algorithms with unknown phase shifts, the proposed algorithm reveals significantly faster computation speed, higher accuracy, better stability and non-sensitivity of phase shifts deviation.

  10. The hidden shift: how do night shift nurses learn to adapt to circadian disruption?

    PubMed

    Lawson Carney, Mary

    2013-01-01

    Disruption of circadian rhythm has a significant impact on the physical, psychosocial, and professional lives of night shift nurses. How night shift nurses learn the coping techniques they employ to adapt to this disruption was examined in a qualitative, cross-sectional survey of 42 nurses. A template analysis technique was used to categorize the responses, which were then compared to industry "best practices" in fatigue countermeasures. Results documented the variety of sleep/wake routines nurses employ to cope with circadian disruption as well as a wide-ranging variety of behaviors related to driving while fatigued.

  11. Water-gas-shift reaction on metal nanoparticles and surfaces

    NASA Astrophysics Data System (ADS)

    Liu, Ping; Rodriguez, José A.

    2007-04-01

    Density functional theory was employed to investigate the water-gas-shift reaction (WGS, CO +H2O→H2+CO2) on Au29 and Cu29 nanoparticles seen with scanning tunneling microscopy in model Au /CeO2(111) and Cu /CeO2(111) catalysts. Au(100) and Cu(100) surfaces were also included for comparison. According to the calculations of the authors, the WGS on these systems operate via either redox or associative carboxyl mechanism, while the rate-limiting step is the same, water dissociation. The WGS activity decreases in a sequence: Cu29>Cu(100)>Au29>Au(100), which agrees well with the experimental observations. Both nanoparticles are more active than their parent bulk surfaces. The nanoscale promotion on the WGS activity is associated with the low-coordinated corner and the edge sites as well as the fluxionality of the particles, which makes the nanoparticles more active than the flat surfaces for breaking the O-H bond. In addition, the role of the oxide support during the WGS was addressed by comparing the activity seen in the calculations of the authors for the Au29 and Cu29 nanoparticles and activity reported for X /CeO2(111) and X /ZnO(000ı¯)(X =Cu or Au) surfaces.

  12. Urban Stormwater Governance: The Need for a Paradigm Shift.

    PubMed

    Dhakal, Krishna P; Chevalier, Lizette R

    2016-05-01

    Traditional urban stormwater management involves rapid removal of stormwater through centralized conveyance systems of curb-gutter-pipe networks. This results in many adverse impacts on the environment including hydrological disruption, groundwater depletion, downstream flooding, receiving water quality degradation, channel erosion, and stream ecosystem damage. In order to mitigate these adverse impacts, urban stormwater managers are increasingly using green infrastructure that promote on-site infiltration, restore hydrological functions of the landscape, and reduce surface runoff. Existing stormwater governance, however, is centralized and structured to support the conventional systems. This governance approach is not suited to the emerging distributed management approach, which involves multiple stakeholders including parcel owners, government agencies, and non-governmental organizations. This incongruence between technology and governance calls for a paradigm shift in the governance from centralized and technocratic to distributed and participatory governance. This paper evaluates how five US cities have been adjusting their governance to address the discord. Finally, the paper proposes an alternative governance model, which provides a mechanism to involve stakeholders and implement distributed green infrastructure under an integrative framework.

  13. Health Literacy Research and Practice: A Needed Paradigm Shift.

    PubMed

    Pleasant, Andrew; Cabe, Jennifer; Patel, Kavita; Cosenza, Jennifer; Carmona, Richard

    2015-01-01

    As a field of research, a viable approach to improving health outcomes, and an important area of policy, health literacy has experienced significant growth and considerable evolution since its broad introduction in the 1990s. Despite that history, far too many practitioners, researchers, and policymakers focusing on clinical medicine, health systems, public health, and health policy remain unaware of and unaffected by the best practices of health literacy. While the inherent promise of health literacy is improved health and well-being, the bulk of research has focused on identifying the negative effects of a lack of health literacy. This strategy is a hindrance to further identifying the utility and increasing the uptake of lessons learned about health literacy in government, business, health care systems, and society. The field needs to reverse direction away from that deficit model of health literacy and focus collective efforts on a positive model of how health literacy can and should be prioritized and utilized to improve health at lower costs. This shift from framing health literacy as a problem to proving the viability and strength of health literacy as a solution will present to policymakers a clear choice to either adopt and promote the best practices of health literacy or suffer the consequences of being the leader who ignored a proven, viable solution to the currently unsustainable health care expenditures and ever-increasing burden of preventable disease, disability, and early death.

  14. Urban Stormwater Governance: The Need for a Paradigm Shift

    NASA Astrophysics Data System (ADS)

    Dhakal, Krishna P.; Chevalier, Lizette R.

    2016-05-01

    Traditional urban stormwater management involves rapid removal of stormwater through centralized conveyance systems of curb-gutter-pipe networks. This results in many adverse impacts on the environment including hydrological disruption, groundwater depletion, downstream flooding, receiving water quality degradation, channel erosion, and stream ecosystem damage. In order to mitigate these adverse impacts, urban stormwater managers are increasingly using green infrastructure that promote on-site infiltration, restore hydrological functions of the landscape, and reduce surface runoff. Existing stormwater governance, however, is centralized and structured to support the conventional systems. This governance approach is not suited to the emerging distributed management approach, which involves multiple stakeholders including parcel owners, government agencies, and non-governmental organizations. This incongruence between technology and governance calls for a paradigm shift in the governance from centralized and technocratic to distributed and participatory governance. This paper evaluates how five US cities have been adjusting their governance to address the discord. Finally, the paper proposes an alternative governance model, which provides a mechanism to involve stakeholders and implement distributed green infrastructure under an integrative framework.

  15. Topological Imbert-Fedorov Shift in Weyl Semimetals

    NASA Astrophysics Data System (ADS)

    Jiang, Qing-Dong; Jiang, Hua; Liu, Haiwen; Sun, Qing-Feng; Xie, Xin-Cheng

    The Goos-Hänchen (GH) shift and the Imbert-Fedorov (IF) shift are optical phenomena which describe the longitudinal and transverse lateral shifts at the reflection interface, respectively. Here, we predict the GHIF shifts in Weyl semimetals (WSMs)--a promising material harboring low energy Weyl fermions, afermionic cousin of photons. Our results show that the GH shift in WSMs is valley independent,is analogous to that discovered in a 2D relativistic material--graphene. However, the IF shift hasbeen explored in nonoptical systems, and here we show that it is valley dependent. Furthermore, wethat the IF shift actually originates from the topological effect of the system. Experimentally, theIF shift can be utilized to characterize theWeyl semimetals, design valleytronic devices of high, and measure the Berry curvature. Morever, we investigate the transport properties of topological semimetal using the wave-packet dynamics, which give some interesting results. NBRP of China, NSF-China.

  16. Quantitative Measurement of the Doppler Shift at an Ultrasonic Frequency

    ERIC Educational Resources Information Center

    Nerbun, R. C.; Leskovec, R. A.

    1976-01-01

    Discussed is a Doppler shift laboratory experiment for an introductory college physics course. Ultrasonic transducers and a digital phase detector circuit "black box" are used to overcome room noise and "standing waves" and to produce an observable frequency shift. (SL)

  17. Goos-Hänchen shift in negatively refractive media.

    PubMed

    Berman, P R

    2002-12-01

    The Goos-Hänchen shift is calculated when total internal reflection occurs at an interface between "normal" and negatively refractive media. The shift is negative, consistent with the direction of energy flow in the negatively refractive medium.

  18. Vegetation zones shift in changing climate

    NASA Astrophysics Data System (ADS)

    Belda, Michal; Halenka, Tomas; Kalvova, Jaroslava; Holtanova, Eva

    2016-04-01

    The analysis of climate patterns can be performed for each climate variable separately or the data can be aggregated using e.g. some kind of climate classification. These classifications usually correspond to vegetation distribution in the sense that each climate type is dominated by one vegetation zone or eco-region. In case of the Köppen-Trewartha classification it is integrated assessment of temperature and precipitation together with their annual cycle as well. This way climate classifications also represent a convenient tool for the assessment and validation of climate models and for the analysis of simulated future climate changes. The Köppen-Trewartha classification is used on full CMIP5 family of more than 40 GCM simulations and CRU dataset for comparison. This evaluation provides insight on the GCM performance and errors for simulations of the 20th century climate. Common regions are identified, such as Australia or Amazonia, where many state-of-the-art models perform inadequately. Furthermore, the analysis of the CMIP5 ensemble for RCP 4.5 and 8.5 is performed to assess the climate change for future. There are significant changes for some types in most models e.g. increase of savanna and decrease of tundra for the future climate. For some types significant shifts in latitude can be seen when studying their geographical location in selected continental areas, e.g. toward higher latitudes for boreal climate. For Europe, EuroCORDEX results for both 0.11 and 0.44 degree resolution are validated using Köppen-Trewartha types in comparison to E-OBS based classification. ERA-Interim driven simulations are compared to both present conditions of CMIP5 models as well as their downscaling by EuroCORDEX RCMs. Finally, the climate change signal assessment is provided using the individual climate types. In addition to the changes assessed similarly as for GCMs analysis in terms of the area of individual types, in the continental scale some shifts of boundaries

  19. Factors affecting work ability in day and shift-working nurses.

    PubMed

    Camerino, Donatella; Conway, Paul Maurice; Sartori, Samantha; Campanini, Paolo; Estryn-Béhar, Madeleine; van der Heijden, Beatrice Isabella Johanna Maria; Costa, Giovanni

    2008-04-01

    Satisfactory work ability is sustained and promoted by good physical and mental health and by favorable working conditions. This study examined whether favorable and rewarding work-related factors increased the work ability among European nurses. The study sample was drawn from the Nurses' Early Exit Study and consisted of 7,516 nursing staff from seven European countries working in state-owned and private hospitals. In all, 10.8% were day, 4.2% were permanent night, 20.9% were shift without night shift, and 64.1% were shift workers with night shifts. Participants were administered a composite questionnaire at baseline (Time 0) and 1 yr later (Time 1). The Work Ability Index (WAI) at Time 1 was used as the outcome measure, while work schedule, sleep, rewards (esteem and career), satisfaction with pay, work involvement and motivation, and satisfaction with working hours at Time 0 were included as potential determinants of work ability. Univariate and multivariate analyses were conducted after adjusting for a number of confounders (i.e., country, age, sex, type of employment, family status, and other job opportunities in the same area). Work schedule was not related to Time 1 changes in WAI. Higher sleep quality and quantity and more favorable psychosocial factors significantly increased work ability levels. Higher sleep quality and quantity did not mediate the effect of work schedule on work ability. No relevant interaction effects on work ability were observed between work schedule and the other factors considered at Time 0. As a whole, sleep and satisfaction with working time were gradually reduced from day work to permanent night work. However, scores on work involvement, motivation, and satisfaction with pay and rewards were the highest in permanent night workers and the lowest in rotating shift workers that included night shifts.

  20. 30 CFR 75.362 - On-shift examination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.362 On-shift examination. (a) (1) At... during the shift and any area where mechanized mining equipment is being installed or removed during the... in the mine ventilation plan. In those instances when a shift change is accomplished without...

  1. 30 CFR 75.362 - On-shift examination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.362 On-shift examination. (a) (1) At... during the shift and any area where mechanized mining equipment is being installed or removed during the... in the mine ventilation plan. In those instances when a shift change is accomplished without...

  2. Toward a taxonomy of attention shifting: individual differences in fMRI during multiple shift types.

    PubMed

    Wager, Tor D; Jonides, John; Smith, Edward E; Nichols, Thomas E

    2005-06-01

    Although task switching is often considered one of the fundamental abilities underlying executive functioning and general intelligence, there is little evidence that switching is a unitary construct and little evidence regarding the relationship between brain activity and switching performance. We examined individual differences in multiple types of attention shifting in order to determine whether behavioral performance and fMRI activity are correlated across different types of shifting. The participants (n = 39) switched between objects and attributes both when stimuli were perceptually available (external) and when stimuli were stored in memory (internal). We found that there were more switch-related activations in many regions associated with executive control--including the dorsolateral and medial prefrontal and parietal cortices--when behavioral switch costs were higher (poor performance). Conversely, activation in the ventromedial prefrontal cortex (VMPFC) and the rostral anterior cingulate was consistently correlated with good performance, suggesting a general role for these areas in efficient attention shifting. We discuss these findings in terms of a model of cognitive-emotional interaction in attention shifting, in which reward-related signals in the VMPFC guide efficient selection of tasks in the lateral prefrontal and parietal cortices.

  3. Using Tensor Light Shifts to Measure and Cancel a Cell's Quadruopolar Frequency Shift

    NASA Astrophysics Data System (ADS)

    Hunter, Larry; Peck, Stephen; Lane, Nathanael; Ang, Daniel

    2016-05-01

    We have developed a new technique that uses the tensor light shift to measure and cancel the frequency shift produced by the quadrupolar anisotropy of a vapor cell. We demonstrate the technique on the 6 S1/2, F = 4 level of Cs using the D1 transition. The method extends our ability to study quadrupolar wall interactions beyond diamagnetic atoms. We have deduced the twist angle per wall adhesion for cesium on an alkene coating to be about 1.4 mrad. This value is about 37 times larger than the twist angle observed in 131 Xe, suggesting that it is not produced by the interaction of the nuclear quadrupole moment with a collisional electric-field gradient. Alternative mechanisms that may be responsible for the observed quadrupolar frequency shifts are discussed. By cancelling the cell-induced quadrupole shift we have extended our cells' effective spin-relaxation times by as much as a factor of two. This cancellation improves magnetometer sensitivity in highly anisotropic cells and could reduce systematic uncertainties in some precision measurements. This work was supported by NSF Grant No. PHY1205824 and No. PHY1519265.

  4. Statistical properties of phase-shift algorithms

    NASA Astrophysics Data System (ADS)

    Rathjen, C.

    1995-09-01

    Statistical properties of phase-shift algorithms are investigated for the case of additive Gaussian intensity noise. Based on a bivariate normal distribution, a generally valid probability-density function for the random phase error is derived. This new description of the random phase error shows properties that cannot be obtained through Gaussian error propagation. The assumption of a normally distributed phase error is compared with the derived probability-density function. For small signal-to-noise ratios the assumption of a normally distributed phase error is not valid. Additionally, it is shown that some advanced systematic-error-compensating algorithms have a disadvantageous effect on the random phase error. error, systematic error, additive Gaussian noise, phase-measuring interferometry.

  5. Shifted power method for computing tensor eigenpairs.

    SciTech Connect

    Mayo, Jackson R.; Kolda, Tamara Gibson

    2010-10-01

    Recent work on eigenvalues and eigenvectors for tensors of order m {>=} 3 has been motivated by applications in blind source separation, magnetic resonance imaging, molecular conformation, and more. In this paper, we consider methods for computing real symmetric-tensor eigenpairs of the form Ax{sup m-1} = {lambda}x subject to {parallel}x{parallel} = 1, which is closely related to optimal rank-1 approximation of a symmetric tensor. Our contribution is a novel shifted symmetric higher-order power method (SS-HOPM), which we showis guaranteed to converge to a tensor eigenpair. SS-HOPM can be viewed as a generalization of the power iteration method for matrices or of the symmetric higher-order power method. Additionally, using fixed point analysis, we can characterize exactly which eigenpairs can and cannot be found by the method. Numerical examples are presented, including examples from an extension of the method to fnding complex eigenpairs.

  6. Thermal momentum distribution from shifted boundary conditions

    NASA Astrophysics Data System (ADS)

    Giusti, L.

    At finite temperature the distribution of the total momentum is an observable characterizing the thermal state of a field theory, and its cumulants are related to thermodynamic potentials. In a relativistic system at zero chemical potential, for instance, the thermal variance of the total momentum is a direct measure of the entropy. We relate the generating function of the cumulants to the ratio of a path integral with properly shifted boundary conditions in the compact direction over the ordinary partition function. In this form it is well suited for Monte-Carlo evaluation, and the cumulants can be extracted straightforwardly. We test the method in the SU(3) Yang--Mills theory, and obtain the entropy density at three different temperatures.

  7. High precision phase-shifting electron holography

    PubMed

    Yamamoto; Kawajiri; Tanji; Hibino; Hirayama

    2000-01-01

    Today's information-oriented society requires high density and high quality magnetic recording media. The quantitative observation of fine magnetic structures by electron holography is greatly anticipated in the development of such new recording materials. However, the magnetic fields around particles <50 nm have not been observed, because the fields are too weak to observe in the usual way. Here we present a highly precise phase measurement technique: improved phase-shifting electron holography. Using this method, the electric field around a charged polystyrene latex particle (100 nm in diameter) and the magnetic field around iron particles (30 nm in diameter) are observed precisely. A precision of the reconstructed phase image of 2pi/300 rad is achieved in the image of the latex particle.

  8. Phase-shifting point diffraction interferometer

    DOEpatents

    Medecki, Hector

    1998-01-01

    Disclosed is a point diffraction interferometer for evaluating the quality of a test optic. In operation, the point diffraction interferometer includes a source of radiation, the test optic, a beam divider, a reference wave pinhole located at an image plane downstream from the test optic, and a detector for detecting an interference pattern produced between a reference wave emitted by the pinhole and a test wave emitted from the test optic. The beam divider produces separate reference and test beams which focus at different laterally separated positions on the image plane. The reference wave pinhole is placed at a region of high intensity (e.g., the focal point) for the reference beam. This allows reference wave to be produced at a relatively high intensity. Also, the beam divider may include elements for phase shifting one or both of the reference and test beams.

  9. Phase-shifting point diffraction interferometer

    DOEpatents

    Medecki, H.

    1998-11-10

    Disclosed is a point diffraction interferometer for evaluating the quality of a test optic. In operation, the point diffraction interferometer includes a source of radiation, the test optic, a beam divider, a reference wave pinhole located at an image plane downstream from the test optic, and a detector for detecting an interference pattern produced between a reference wave emitted by the pinhole and a test wave emitted from the test optic. The beam divider produces separate reference and test beams which focus at different laterally separated positions on the image plane. The reference wave pinhole is placed at a region of high intensity (e.g., the focal point) for the reference beam. This allows reference wave to be produced at a relatively high intensity. Also, the beam divider may include elements for phase shifting one or both of the reference and test beams. 8 figs.

  10. Paradigm Shifts in the Treatment of Appendicitis.

    PubMed

    Mak, Grace Zee; Loeff, Deborah S

    2016-07-01

    Acute appendicitis is the most common cause of emergent surgery in children. Historically, surgical dogma dictated emergent appendectomy due to concern for impending perforation. Recently, however, there has been a paradigm shift in both the understanding of its pathophysiology as well as its treatment to more nonoperative management. No longer is it considered a spectrum from uncomplicated appendicitis inevitably progressing to complicated appendicitis over time. Rather, uncomplicated and complicated appendicitis are now considered two distinct pathophysiologic entities. This change requires not only educating the patients and their families but also the general practitioners who will be managing treatment expectations and caring for patients long term. In this article, we review the pathophysiology of appendicitis, including the differentiation between uncomplicated and complicated appendicitis, as well as the new treatment paradigms. [Pediatr Ann. 2016;45(7):e235-e240.].

  11. Shifting environmental baselines in the Red Sea.

    PubMed

    Price, A R G; Ghazi, S J; Tkaczynski, P J; Venkatachalam, A J; Santillan, A; Pancho, T; Metcalfe, R; Saunders, J

    2014-01-15

    The Red Sea is among the world's top marine biodiversity hotspots. We re-examined coastal ecosystems at sites surveyed during the 1980s using the same methodology. Coral cover increased significantly towards the north, mirroring the reverse pattern for mangroves and other sedimentary ecosystems. Latitudinal patterns are broadly consistent across both surveys and with results from independent studies. Coral cover showed greatest change, declining significantly from a median score of 4 (1000-9999 m(2)) to 2 (10-99m(2)) per quadrat in 2010/11. This may partly reflect impact from coastal construction, which was evident at 40% of sites and has significantly increased in magnitude over 30 years. Beach oil has significantly declined, but shore debris has increased significantly. Although substantial, levels are lower than at some remote ocean atolls. While earlier reports have suggested that the Red Sea is generally healthy, shifting environmental baselines are evident from the current study.

  12. Stokes shift spectroscopy for breast cancer diagnosis

    NASA Astrophysics Data System (ADS)

    Jeyasingh, Ebenezar; Prakashrao, Aruna; Singaravelu, Ganesan

    2010-02-01

    The objective of this study is to assess the diagnostic potential of stokes shift (SS) spectroscopy (SSS) for normal and different pathological breast tissues such as fibroadenoma and infiltrating ductal carcinoma. The SS spectra is measured by simultaneously scanning both the excitation and emission wavelengths while keeping a fixed wavelength interval Δλ=20 nm between them. Characteristic, highly resolved peaks and significant spectral differences between normal and different pathological breast tissues were observed. The SS spectra of normal and different pathological breast tissues shows the distinct peaks around 300, 350, 450, 500 and 600 nm may be attributed to tryptophan, collagen, NADH, flavin and porphyrin respectively. Using SSS technique one can obtain all the key fluorophores in a single scan and hence they can be targeted as a tumor markers in this study. In order to quantify the altered spectral differences between normal and different pathological breast tissues are verified by different ratio parameters.

  13. Competitive environments induce shifts in host fidelity.

    PubMed

    Rova, E; Björklund, M

    2010-08-01

    Recent models support the idea of sympatric speciation as a result of the joint effects of disruptive selection and assortative mating. We present experimental data, testing models of speciation through frequency-dependent selection. We show that under high competition on a mixture of resources/hosts, strains of the Seed beetle, Callosobruchus maculatus, change their host fidelity and evolve a more generalistic behaviour in resource utilization among females. The change in host fidelity did not result in disruptive selection and was not followed by assortative mating. This means that only one of three fundamental prerequisites for sympatric speciation evolved as a result of the frequency-dependent selection. We conclude that for this process to work, a shift to a novel food resource as a result of selection must also lead to a loss of preference for the original resource such that individuals are only able to use either one of the two.

  14. Quantum walks with random phase shifts

    SciTech Connect

    Kosik, Jozef; Buzek, Vladimir; Hillery, Mark

    2006-08-15

    We investigate quantum walks in multiple dimensions with different quantum coins. We augment the model by assuming that at each step the amplitudes of the coin state are multiplied by random phases. This model enables us to study in detail the role of decoherence in quantum walks and to investigate the quantum-to-classical transition. We also provide classical analog of the quantum random walks studied. Interestingly enough, it turns out that the classical counterparts of some quantum random walks are classical random walks with a memory and biased coin. In addition random phase shifts 'simplify' the dynamics (the cross-interference terms of different paths vanish on average) and enable us to give a compact formula for the dispersion of such walks.

  15. Cooperative Lamb shift in an ellipsoid

    SciTech Connect

    Friedberg, Richard; Manassah, Jamal T.

    2010-06-15

    It has been long known that the global cooperative Lamb shift (CLS) in a large superradiantly emitting sphere has equal magnitude but opposite sign to that of a slab. This result was obtained from QED in 1973 for samples of uniform density. This change of sign holds as well for a Gaussian density distribution. The same result is also obtained for either density in the scalar simplification of QED now in frequent use. Since the CLS must be a continuous function of shape, and the slab resembles a limiting case of oblate ellipsoid, there must be some shape of ellipsoid for which the CLS is zero. We report a calculation of CLS for a Gaussian distribution of general azimuthally symmetric ellipsoidal shape. The CLS is found to vanish when the mean square radius is twice as great transversely as longitudinally.

  16. Nonrelativistic QED approach to the Lamb shift

    SciTech Connect

    Jentschura, Ulrich D.; Czarnecki, Andrzej; Pachucki, Krzysztof

    2005-12-15

    We calculate the one- and two-loop corrections of order {alpha}(Z{alpha}){sup 6} and {alpha}{sup 2}(Z{alpha}){sup 6}, respectively, to the Lamb shift in hydrogenlike systems using the formalism of nonrelativistic quantum electrodynamics. We obtain general results valid for all hydrogenic states with nonvanishing orbital angular momentum and for the normalized difference of S states. These results involve the expectation value of local effective operators and relativistic corrections to Bethe logarithms. The one-loop correction is in agreement with previous calculations for the particular cases of S, P, and D states. The two-loop correction in the order {alpha}{sup 2}(Z{alpha}){sup 6} includes the pure two-loop self-energy and all diagrams with closed fermion loops. The obtained results allow one to obtain improved theoretical predictions for all excited hydrogenic states.

  17. New walking and cycling infrastructure and modal shift in the UK: A quasi-experimental panel study.

    PubMed

    Song, Yena; Preston, John; Ogilvie, David

    2017-01-01

    Heavy dependency on car use leads to traffic congestion, pollution, and physical inactivity, which impose high direct and indirect costs on society. Promoting walking and cycling has been recognised as one of the means of mitigating such negative effects. Various approaches have been taken to enhance walking and cycling levels and to reduce the use of automobiles. This paper examines the effectiveness of infrastructure interventions in promoting walking and cycling for transport. Two related sets of panel data, covering elapsed time periods of one and two years, were analysed to track changes in travel behaviour following provision of new walking and cycling infrastructure so that modal shift from private car use to walking and cycling can be investigated. Two types of exposure measures were tested: distance from the infrastructure (a measure of potential usage), and actual usage of the infrastructure. Only the latter measure was statistically significantly associated with modal shift. This in turn suggested that infrastructure provision was not a sufficient condition for modal shift, but may have been a necessary condition. Along with the use of new infrastructure, the loss of employment, higher education, being male and being part of the ethnic majority were consistently found to be significantly and positively associated with modal shift towards walking and cycling. The findings of this study support the construction of walking and cycling routes, but also suggest that such infrastructure alone may not be enough to promote active travel.

  18. Timing shifts due to NIF beam repointing

    SciTech Connect

    Koch, J

    2007-08-15

    Repointing a NIF beam to hit a target position off target chamber center (TCC) will introduce a timing shift due to changes in the light pathlength. This shift could be important for target experiment requirements even for targets placed at TCC, since beam timing test shots will place beams up to 15 mm off TCC in order to spatially separate them on foil targets. In particular, timing errors due to beam repointing need to be considered against the 30 ps RMS timing requirement. Since the repointing process will keep the beam passing through a fixed point in the final optics assembly (the conversion crystal) by tip/tilt adjustments of two turning mirrors (LM5 and LM7), the problem naturally divides into two parts: Timing offsets past the conversion crystal due to target positioning changes, and timing offsets behind the fixed point on the conversion crystal due to turning mirror adjustments. Timing offsets past the conversion crystal can be significant, but are trivial to calculate exactly; however, an exact calculation of timing offsets behind the fixed point on the conversion crystal would require a three-dimensional optomechanical raytrace model to be developed for every beamline, and this would be difficult and expensive. In this memo, I estimate the magnitude of timing offsets due to pathlength changes behind the conversion crystal by analysis of a worst-case model. I conclude that these timing offsets are insignificant compared with the current allocation in the 30 ps RMS timing requirement, and that more detailed raytrace modeling of individual beams is not necessary.

  19. Achromatic phase shifting focal plane masks

    NASA Astrophysics Data System (ADS)

    Newman, Kevin

    The search for life on other worlds is an exciting scientific endeavor that could change the way we perceive our place in the universe. Thousands of extrasolar planets have been discovered using indirect detection techniques. One of the most promising methods for discovering new exoplanets and searching for life is direct imaging with a coronagraph. Exoplanet coronagraphy of Earth-like planets is a challenging task, but we have developed many of the tools necessary to make it feasible. The Phase-Induced Amplitude Apodization (PIAA) Coronagraph is one of the highest-performing architectures for direct exoplanet imaging. With a complex phase-shifting focal plane mask, the PIAA Complex Mask Coronagraph (PIAACMC) can approach the theoretical performance limit for any direct detection technique. The architecture design is flexible enough to be applied to any arbitrary aperture shape, including segmented and obscured apertures. This is an important feature for compatibility with next-generation ground and space-based telescopes. PIAA and PIAACMC focal plane masks have been demonstrated in monochromatic light. An important next step for high-performance coronagraphy is the development of broadband phase-shifting focal plane masks. In this dissertation, we present an algorithm for designing the PIAA and PIAACMC focal plane masks to operate in broadband. We also demonstrate manufacturing of the focal plane masks, and show laboratory results. We use simulations to show the potential performance of the coronagraph system, and the use of wavefront control to correct for mask manufacturing errors. Given the laboratory results and simulations, we show new areas of exoplanet science that can potentially be explored using coronagraph technology. The main conclusion of this dissertation is that we now have the tools required to design and manufacture PIAA and PIAACMC achromatic focal plane masks. These tools can be applied to current and future telescope systems to enable new

  20. Residual renal function: a paradigm shift.

    PubMed

    Lowenstein, Jerome; Grantham, Jared J

    2017-03-01

    Residual renal function (RRF) in patients undergoing dialysis treatments is currently viewed as glomerular filtrate that has escaped tubular reabsorption. RRF has been quantified as a clearance of urea or creatinine, or urea + creatinine. A major paradigm shift has followed the recognition that a substantial number of organic anion retention solutes (possible "uremic toxins") are protein-bound and therefore are not readily filtered. These protein-bound aryl compounds are secreted by renal tubular organic anion transporters (OATs). This has led to the recognition that RRF in dialysis patients probably represents not only unreabsorbed glomerular filtrate but also a contribution of renal tubular transporters that secrete organic anions. Tubular secretion of hippurate, indoxyl sulfate, and p-cresol sulfate, protein-bound organic anions retained in the plasma of end-stage renal disease patients, can be quantified and used to evaluate the integrity of a function dependent on active solute transport. Here we propose a shift away from the exclusive "glomerulocentric" view of RRF as unreabsorbed glomerular filtrate and of the progression of renal disease as progressive glomerular loss. We expand the definition of RRF to include the combined renal and tubule functions remaining after a disease begins to destroy nephrons and proceeds to anuria. We propose renewed application of the first principles of renal physiology, articulated in the last century by Homer Smith, to the understanding and monitoring of RRF and progression of renal injury in patients during the sometimes long course of and at the end stage of chronic renal disease.

  1. Phenological shifts and the fate of mutualisms

    PubMed Central

    Rafferty, Nicole E.; CaraDonna, Paul J.; Bronstein, Judith L.

    2014-01-01

    Climate change is altering the timing of life history events in a wide array of species, many of which are involved in mutualistic interactions. Because many mutualisms can form only if partner species are able to locate each other in time, differential phenological shifts are likely to influence their strength, duration and outcome. At the extreme, climate change-driven shifts in phenology may result in phenological mismatch: the partial or complete loss of temporal overlap of mutualistic species. We have a growing understanding of how, when, and why phenological change can alter one type of mutualism–pollination. However, as we show here, there has been a surprising lack of attention to other types of mutualism. We generate a set of predictions about the characteristics that may predispose mutualisms in general to phenological mismatches. We focus not on the consequences of such mismatches but rather on the likelihood that mismatches will develop. We explore the influence of three key characteristics of mutualism: 1) intimacy, 2) seasonality and duration, and 3) obligacy and specificity. We predict that the following characteristics of mutualism may increase the likelihood of phenological mismatch: 1) a non-symbiotic life history in which co-dispersal is absent; 2) brief, seasonal interactions; and 3) facultative, generalized interactions. We then review the limited available data in light of our a priori predictions and point to mutualisms that are more and less likely to be at risk of becoming phenologically mismatched, emphasizing the need for research on mutualisms other than plant–pollinator interactions. Future studies should explicitly focus on mutualism characteristics to determine whether and how changing phenologies will affect mutualistic interactions. PMID:25883391

  2. Isotope shift constant and nuclear charge model

    NASA Astrophysics Data System (ADS)

    Fang, Z.; Redi, O.; Stroke, H. H.

    1992-04-01

    We use the method of Zimmermann [Z. Phys. A 321 (1985) 23-30], which he used to calculate the isotope shift constant for a uniform nuclear charge distribution, to obtain it for a diffuse nuclear charge model. The two models give results that differ slightly on the level of precision of current experiments. The same parameters are used to calculate the model sensitivity of the contributions to the isotope shifts of higher moments of the nuclear charge distribution as formulated by Seltzer [Phys. Rev. 188 (1969) 1916-1919]. These are found to be essentially model independent. Tables are given of the numerical calculations. Nous employons la méthode de Zimmermann [Z. Phys. A 321 (1985) 23-30], qu'il avait utilisé dans un calcul de la constante du déplacement isotopique pour une distribution de charge uniforme, pour l'obtenir avec un modèle de charge nucléaire avec forme quasi-trapézoïdale. Les deux modèles donnent des résultats dont la difference excède de peu la précision des mesures actuelles. Les mêmes paramètres sont utilisés pour comparer la dépendance aux deux modèles de la contribution au déplacement isotopique des moments plus élevés de la distribution de la charge nucléaire dans la formulation de Seltzer [Phys. Rev. 188 (1969) 1916-1919]. On trouve que ces contributions sont essentiellement indépendantes du modèle. Des tables de calculs numériques sont présentées.

  3. Distribution of rest days in 12 hour shift systems: impacts on health, wellbeing, and on shift alertness

    PubMed Central

    Tucker, P.; Smith, L.; Macdonald, I.; Folkard, S.

    1999-01-01

    OBJECTIVES: To investigate of the effects of distribution of rest days in 12 hour shift systems. Although several studies have examined the effects of compressing work schedules by comparing 8 and 12 hour shift systems, there is little published research examining the various forms of 12 hour shift system. METHODS: An abridged version of the standard shiftwork index which included retrospective alertness ratings was completed by a large sample of industrial shiftworkers. The respondents worked 12 hour shift systems that either did or did not incorporate breaks of > 24 hours between the blocks of day and night shifts. For the purposes of the analysis, each of these two groups were further subdivided into those who started their morning shift at 0600 and those who started at 0700. RESULTS: Systems which incorporated rest days between the day and night shifts were associated with slightly higher levels of on shift alertness, slightly lower levels of chronic fatigue, along with longer sleep durations when working night shifts and between rest days. Early changeovers were associated with shorter night sleeps between successive day shifts, but longer and less disturbed day sleeps between night shifts. These effects of changeover time were broadly in agreement with previous research findings. CONCLUSIONS: The distribution of rest days in 12 hour shift systems had only limited effects on the outcome measures, although the few modest differences that were found favoured systems which incorporated rest days between the day and night shifts. It is conceded that the design of the study may have obscured some subtle differences between the shift systems. Nevertheless, it is concluded that the impact of distribution of rest days seems to be minor relative to previously found effects of other features of shift systems--for example, shift duration.   PMID:10448331

  4. Phase-shifting behaviour revisited: An alternative measure

    NASA Astrophysics Data System (ADS)

    Kang, Bo Soo; Ryu, Doojin; Ryu, Doowon

    2014-05-01

    This study re-examines the recently documented phase-shifting behaviour of financial markets using an alternative measure, an intraday return-based measure. While most previous studies on phase-shifting behaviour adopt the volume-imbalance measure proposed by Plerou et al. (2003), we find that our return-based measure successfully captures phase-shifting behaviour, and moreover exhibits a unique pattern of phase-shifting that is not detected when the classical volume imbalance measure is used. By analysing a high-frequency dataset of KOSPI200 futures, we also find that large trades reveal phase-shifting behaviour more clearly and significantly than smaller trades.

  5. High-speed optical phase-shifting apparatus

    SciTech Connect

    Zortman, William A.

    2016-11-08

    An optical phase shifter includes an optical waveguide, a plurality of partial phase shifting elements arranged sequentially, and control circuitry electrically coupled to the partial phase shifting elements. The control circuitry is adapted to provide an activating signal to each of the N partial phase shifting elements such that the signal is delayed by a clock cycle between adjacent partial phase shifting elements in the sequence. The transit time for a guided optical pulse train between the input edges of consecutive partial phase shifting elements in the sequence is arranged to be equal to a clock cycle, thereby enabling pipelined processing of the optical pulses.

  6. Effects of pharmacological agents on subcortical resistance shifts

    NASA Technical Reports Server (NTRS)

    Klivington, K. A.

    1975-01-01

    Microliter quantities of tetrodotoxin, tetraethylammonium chloride, and picrotoxin injected into the inferior colliculus and superior olive of unanesthetized cats differentially affect the amplitude and waveform of click-evoked potentials and evoked resistance shifts. Tetrodotoxin simultaneously reduces the negative phase of the evoked potential and eliminates the evoked resistance shift. Tetraethylammonium enhances the negative evoked potential component, presumably of postsynaptic origin, without significantly altering evoked resistance shift amplitude. Picrotoxin also enhances the negative evoked potential wave but increases evoked resistance shift amplitude. These findings implicate events associated with postsynaptic membrane depolarization in the production of the evoked resistance shift.

  7. s-Wave collisional frequency shift of a fermion clock.

    PubMed

    Hazlett, Eric L; Zhang, Yi; Stites, Ronald W; Gibble, Kurt; O'Hara, Kenneth M

    2013-04-19

    We report an s-wave collisional frequency shift of an atomic clock based on fermions. In contrast to bosons, the fermion clock shift is insensitive to the population difference of the clock states, set by the first pulse area in Ramsey spectroscopy, θ(1). The fermion shift instead depends strongly on the second pulse area θ(2). It allows the shift to be canceled, nominally at θ(2)=π/2, but correlations perturb the null to slightly larger θ(2). The frequency shift is relevant for optical lattice clocks and increases with the spatial inhomogeneity of the clock excitation field, naturally larger at optical frequencies.

  8. C IV Doppler shifts observed in active region filaments

    NASA Technical Reports Server (NTRS)

    Klimchuk, J. A.

    1986-01-01

    The Doppler shift properties of 21 active region filaments were studied using C IV Dopplergram data. Most are associated with corridors of weak magnetic field that separate opposite polarity strong fields seen in photospheric magnetograms. A majority of the filaments are relatively blue shifted, although several lie very close to the dividing lines between blue and red shift. Only one filament in the samples is clearly red shifted. A new calibration procedure for Dopplergrams indicates that sizable zero point offsets are often required. The center-to-limb behavior of the resulting absolute Doppler shifts suggests that filament flows are usually quite small. It is possible that they vanish.

  9. Using chemical shift perturbation to characterise ligand binding.

    PubMed

    Williamson, Mike P

    2013-08-01

    Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced changes in chemical shift, CIS) follows changes in the chemical shifts of a protein when a ligand is added, and uses these to determine the location of the binding site, the affinity of the ligand, and/or possibly the structure of the complex. A key factor in determining the appearance of spectra during a titration is the exchange rate between free and bound, or more specifically the off-rate koff. When koff is greater than the chemical shift difference between free and bound, which typically equates to an affinity Kd weaker than about 3μM, then exchange is fast on the chemical shift timescale. Under these circumstances, the observed shift is the population-weighted average of free and bound, which allows Kd to be determined from measurement of peak positions, provided the measurements are made appropriately. (1)H shifts are influenced to a large extent by through-space interactions, whereas (13)Cα and (13)Cβ shifts are influenced more by through-bond effects. (15)N and (13)C' shifts are influenced both by through-bond and by through-space (hydrogen bonding) interactions. For determining the location of a bound ligand on the basis of shift change, the most appropriate method is therefore usually to measure (15)N HSQC spectra, calculate the geometrical distance moved by the peak, weighting (15)N shifts by a factor of about 0.14 compared to (1)H shifts, and select those residues for which the weighted shift change is larger than the standard deviation of the shift for all residues. Other methods are discussed, in particular the measurement of (13)CH3 signals. Slow to intermediate exchange rates lead to line broadening, and make Kd values very difficult to obtain. There is no good way to distinguish changes in chemical shift due to direct binding of the ligand from changes in chemical shift due to allosteric change. Ligand binding at multiple sites can often be characterised, by

  10. Dietary shifts and implications for US agriculture.

    PubMed

    O'Brien, P

    1995-06-01

    Changes to healthier dietary patterns similar to those of traditional Mediterranean diets or those of the US government's dietary guidelines and food guide pyramid would require significant changes in American agricultural practices. The volume, mix, production, and marketing of agricultural commodities would need to be modified. Because differences between actual and recommended intakes for major food groups are quite large and affect a broad range of products, adjustments in supply and demand could overshadow past experience in dealing with such changes. New food and agriculture policies may well be needed to ease and accelerate agricultural adjustments, to improve nutritional characteristics of popular foods, and to promote desirable changes in consumers' food choices.

  11. Implementing a night-shift clinical nurse specialist.

    PubMed

    Becker, Dawn Marie

    2013-01-01

    Night-shift nurses receive fewer educational opportunities and less administrative support than do day-shift staff, tend to be newer, with less experience and fewer resources, and experience greater turnover rates, stress, and procedural errors. In an attempt to bridge the gap between day- and night-shift nursing, a night-shift clinical nurse specialist (CNS) position was created in a midsized, community teaching hospital. The goal was to provide an advanced practice presence to improve patient outcomes, communication, education, and cost-effectiveness. The night-shift CNS participated in nursing education and skill certifications, communicated new procedures and information, and created a communication committee specifically for night-shift nurses. Through regular rounding and on-call notification, the CNS was available to every area of the hospital for consultation and clinical assistance and assisted with rapid responses, codes, and traumas. Providing education during night shift reduced overtime costs and increased morale, positively affecting turnover rates. The night-shift CNS position has improved morale and equalized support for night-shift nurses. More research, most notably in specific night-shift metrics, is necessary, and with the implementation of the role in additional facilities, more can be understood about improving patient care and nursing staff satisfaction during night shift.

  12. Sleep and cognitive function of crewmembers and mission controllers working 24-h shifts during a simulated 105-day spaceflight mission

    NASA Astrophysics Data System (ADS)

    Barger, Laura K.; Wright, Kenneth P.; Burke, Tina M.; Chinoy, Evan D.; Ronda, Joseph M.; Lockley, Steven W.; Czeisler, Charles A.

    2014-01-01

    The success of long-duration space missions depends on the ability of crewmembers and mission support specialists to be alert and maintain high levels of cognitive function while operating complex, technical equipment. We examined sleep, nocturnal melatonin levels and cognitive function of crewmembers and the sleep and cognitive function of mission controllers who participated in a high-fidelity 105-day simulated spaceflight mission at the Institute of Biomedical Problems (Moscow). Crewmembers were required to perform daily mission duties and work one 24-h extended duration work shift every sixth day. Mission controllers nominally worked 24-h extended duration shifts. Supplemental lighting was provided to crewmembers and mission controllers. Participants' sleep was estimated by wrist-actigraphy recordings. Overall, results show that crewmembers and mission controllers obtained inadequate sleep and exhibited impaired cognitive function, despite countermeasure use, while working extended duration shifts. Crewmembers averaged 7.04±0.92 h (mean±SD) and 6.94±1.08 h (mean±SD) in the two workdays prior to the extended duration shifts, 1.88±0.40 h (mean±SD) during the 24-h work shift, and then slept 10.18±0.96 h (mean±SD) the day after the night shift. Although supplemental light was provided, crewmembers' average nocturnal melatonin levels remained elevated during extended 24-h work shifts. Naps and caffeine use were reported by crewmembers during ˜86% and 45% of extended night work shifts, respectively. Even with reported use of wake-promoting countermeasures, significant impairments in cognitive function were observed. Mission controllers slept 5.63±0.95 h (mean±SD) the night prior to their extended duration work shift. On an average, 89% of night shifts included naps with mission controllers sleeping an average of 3.4±1.0 h (mean±SD) during the 24-h extended duration work shift. Mission controllers also showed impaired cognitive function during extended

  13. Parallel three-step phase-shifting digital holography.

    PubMed

    Awatsuji, Yasuhiro; Fujii, Atsushi; Kubota, Toshihiro; Matoba, Osamu

    2006-05-01

    We propose parallel three-step phase-shifting digital holography as a technique capable of noiseless instantaneous measurement of three-dimensional objects based on phase-shifting interferometry. The proposed digital holography carries out three-step phase shifting at the same time by using a phase-shifting array device located in the reference beam. The array device has a periodic three-step phase distribution, and its configuration is simplified compared with that required for conventional parallel phase-shifting digital holography. Therefore the optical system of the proposed parallel phase-shifting digital holography is more suitable for the realization of the proposed holography. We conduct both a numerical simulation and a preliminary experiment. The results of the simulation and experiment agree well with those of the conventional phase-shifting method and are superior to the results obtained by conventional digital holography by using the Fresnel transform alone. Thus the effectiveness of the proposed technique is verified.

  14. Mapping of protein structural ensembles by chemical shifts.

    PubMed

    Baskaran, Kumaran; Brunner, Konrad; Munte, Claudia E; Kalbitzer, Hans Robert

    2010-10-01

    Applying the chemical shift prediction programs SHIFTX and SHIFTS to a data base of protein structures with known chemical shifts we show that the averaged chemical shifts predicted from the structural ensembles explain better the experimental data than the lowest energy structures. This is in agreement with the fact that proteins in solution occur in multiple conformational states in fast exchange on the chemical shift time scale. However, in contrast to the real conditions in solution at ambient temperatures, the standard NMR structural calculation methods as well chemical shift prediction methods are optimized to predict the lowest energy ground state structure that is only weakly populated at physiological temperatures. An analysis of the data shows that a chemical shift prediction can be used as measure to define the minimum size of the structural bundle required for a faithful description of the structural ensemble.

  15. Formation of charged H3O+ and OH- fragments at consistent shifts of protons in water clusters

    NASA Astrophysics Data System (ADS)

    Bednyakov, A. S.; Novakovskaya, Yu. V.

    2016-09-01

    Probable paths of consistent shifts of bridge protons within the hexamolecular rings of dodecamer water cluster at different arrangement of neighboring molecules are determined. As with individual rings, consistent shifts of protons in molecular cages are found to be promoted by contraction/extension of the oxygen skeleton. Transition states characterized by the formation of different numbers of such charged fragments as H3Oδ+, H5O 2 δ+ , and OH-, are identified. Conditions of the relatively long-term (about picoseconds) existence of the fragments in cluster systems are determined.

  16. Species traits and climate velocity explain geographic range shifts in an ocean-warming hotspot.

    PubMed

    Sunday, Jennifer M; Pecl, Gretta T; Frusher, Stewart; Hobday, Alistair J; Hill, Nicole; Holbrook, Neil J; Edgar, Graham J; Stuart-Smith, Rick; Barrett, Neville; Wernberg, Thomas; Watson, Reg A; Smale, Dan A; Fulton, Elizabeth A; Slawinski, Dirk; Feng, Ming; Radford, Ben T; Thompson, Peter A; Bates, Amanda E

    2015-09-01

    Species' ranges are shifting globally in response to climate warming, with substantial variability among taxa, even within regions. Relationships between range dynamics and intrinsic species traits may be particularly apparent in the ocean, where temperature more directly shapes species' distributions. Here, we test for a role of species traits and climate velocity in driving range extensions in the ocean-warming hotspot of southeast Australia. Climate velocity explained some variation in range shifts, however, including species traits more than doubled the variation explained. Swimming ability, omnivory and latitudinal range size all had positive relationships with range extension rate, supporting hypotheses that increased dispersal capacity and ecological generalism promote extensions. We find independent support for the hypothesis that species with narrow latitudinal ranges are limited by factors other than climate. Our findings suggest that small-ranging species are in double jeopardy, with limited ability to escape warming and greater intrinsic vulnerability to stochastic disturbances.

  17. Evolutionary shifts to self-fertilisation restricted to geographic range margins in North American Arabidopsis lyrata.

    PubMed

    Griffin, P C; Willi, Y

    2014-04-01

    Cross-fertilisation predominates in eukaryotes, but shifts to self-fertilisation are common and ecologically and evolutionarily important. Reproductive assurance under outcross gamete limitation is one eco-evolutionary process held responsible for the shift to selfing. Although small effective population size is a situation where selfing plants could theoretically benefit from reproductive assurance, empirical tests of the role of population size are rare. Here, we show that selfing evolved repeatedly at range margins, where historical demographic processes produced low effective population sizes. Outcrossing populations of North American Arabidopsis lyrata have low genetic diversity at geographic margins, with a signature of post-glacial range expansion in the north and rear-edge isolation in the south. Selfing populations occur at the margins of two genetic groups and never in their interior. These results corroborate small effective population size as the promoter of self-fertilisation and have important implications for our understanding of species turnover, range limits and range dynamics.

  18. Promoting La Cultura Hispana

    ERIC Educational Resources Information Center

    Pluviose, David

    2007-01-01

    Launched in 1985 at Arizona State University, the Hispanic Research Center's (HRC) efforts to promote Latino and Chicano art and issues have flourished in recent years. In 2004, the HRC hosted the Arizona International Latina/o Arts Festival in collaboration with the Mesa Southwest Museum. The HRC has also founded a mentoring institute for…

  19. The Ideal Promotion Effort.

    ERIC Educational Resources Information Center

    Morris, Edward L.

    The ideal promotional effort for an educational television (ETV) station is dependent on a professional approach to the problem. This means that each ETV station should employ a public relations manager and should keep him informed about all major station decisions. The Public Broadcasting Service (PBS) has a campaign of its own to bring attention…

  20. Health Promotion Interventions.

    ERIC Educational Resources Information Center

    Jason, Leonard A.; Curie, Carrie J.; Townsend, Stephanie M.; Pokorny, Steven B.; Katz, Richard B.; Sherk, Joseph L.

    2002-01-01

    Reviews four areas from the prevention science field, including: promoting healthy behavior; preventing substance abuse; preventing high-risk sexual behaviors; and preventing child abuse and sexual abuse. Recommendations are made regarding strategies for implementing empirically validated programs, supplementing school programs with ecological…

  1. Does Paid Promotion Pay?

    ERIC Educational Resources Information Center

    Scherer, Chris

    1980-01-01

    A study to determine the cost effectiveness of newspaper display advertising for cooperative extension programs showed such publicity to be more effective in large metropolitan areas. Though not a technique for increasing enrollment, this method provided long-range benefits in the overall promotion of extension educational services. (SK)

  2. Promoting Healthy Dietary Behaviors.

    ERIC Educational Resources Information Center

    Perry, Cheryl L.; Story, Mary; Lytle, Leslie A.

    This chapter reviews the research on promoting healthy dietary behaviors in all youth, not just those who exhibit problems such as obesity or eating disorders. The first section of this chapter presents a rationale for addressing healthy dietary behavior with children and adolescents, on the basis of the impact of these behaviors on short- and…

  3. Partners: Promoting Accessible Recreation.

    ERIC Educational Resources Information Center

    Sable, Janet; Gravink, Jill

    1995-01-01

    The Promoting Accessible Recreation through Networking, Education, Resources and Services (PARTNERS) Project, a partnership between Northeast Passage, the University of New Hampshire, and Granite State Independent Living Foundation, helps create barrier-free recreation for individuals with physical disabilities. The paper describes PARTNERS and…

  4. Promoting Continuing Education Programs.

    ERIC Educational Resources Information Center

    Hendrickson, Gayle A.

    This handbook is intended for use by institutions in marketing their continuing education programs. A section on "Devising Your Strategy" looks at identifying a target audience, determining the marketing approach, and developing a marketing plan and promotional techniques. A discussion of media options looks at the advantages and…

  5. 50 Practical Promotion Ideas.

    ERIC Educational Resources Information Center

    Madeyski, Tom

    1997-01-01

    Includes 50 cost-effective ideas for promoting camp in the areas of recruiting new campers, encouraging returning campers, advertising strategies, printing brochures and other written materials, using photographs, targeting groups for camp facility rental, and effectively using the media. (LP)

  6. Solvent Effects on Oxygen-17 Chemical Shifts in Amides. Quantitative Linear Solvation Shift Relationships

    NASA Astrophysics Data System (ADS)

    Díez, Ernesto; Fabián, Jesús San; Gerothanassis, Ioannis P.; Esteban, Angel L.; Abboud, José-Luis M.; Contreras, Ruben H.; de Kowalewski, Dora G.

    1997-01-01

    A multiple-linear-regression analysis (MLRA) has been carried out using the Kamlet-Abboud-Taft (KAT) solvatochromic parameters in order to elucidate and quantify the solvent effects on the17O chemical shifts ofN-methylformamide (NMF),N,N-dimethylformamide (DMF),N-methylacetamide (NMA), andN,N-dimethylacetamide (DMA). The chemical shifts of the four molecules show the same dependence (in ppm) on the solvent polarity-polarizability, i.e., -22π*. The influence of the solvent hydrogen-bond-donor (HBD) acidities is slightly larger for the acetamides NMA and DMA, i.e., -48α, than for the formamides NMF and DMF, i.e., -42α. The influence of the solvent hydrogen-bond-acceptor (HBA) basicities is negligible for the nonprotic molecules DMF and DMA but significant for the protic molecules NMF and NMA, i.e., -9β. The effect of substituting the N-H hydrogen by a methyl group amounts to -5.9 ppm in NMF and 5.4 ppm in NMA. The effect of substituting the O=C-H hydrogen amounts to 5.5 ppm in NMF and 16.8 ppm in DMF. The model of specific hydration sites of amides by I. P. Gerothanassis and C. Vakka [J. Org. Chem.59,2341 (1994)] is settled in a more quantitative basis and the model by M. I. Burgar, T. E. St. Amour, and D. Fiat [J. Phys. Chem.85,502 (1981)] is critically evaluated.17O hydration shifts have been calculated for formamide (FOR) by the ab initio LORG method at the 6-31G* level. For a formamide surrounded by the four in-plane molecules of water in the first hydration shell, the calculated17O shift change due to the four hydrogen bonds, -83.2 ppm, is smaller than the empirical hydration shift, -100 ppm. The17O shift change from each out-of-plane water molecule hydrogen-bonded to the amide oxygen is -18.0 ppm. These LORG results support the conclusion that no more than four water molecules are hydrogen-bonded to the amide oxygen in formamide.

  7. The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts

    PubMed Central

    Ferri, Paola; Guadi, Matteo; Marcheselli, Luigi; Balduzzi, Sara; Magnani, Daniela; Di Lorenzo, Rosaria

    2016-01-01

    Background Shift work is considered necessary to ensure continuity of care in hospitals and residential facilities. In particular, the night shift is one of the most frequent reasons for the disruption of circadian rhythms, causing significant alterations of sleep and biological functions that can affect physical and psychological well-being and negatively impact work performance. Objectives The aim of this study was to highlight if shift work with nights, as compared with day work only, is associated with risk factors predisposing nurses to poorer health conditions and lower job satisfaction. Methods This cross-sectional study was conducted from June 1, 2015 to July 31, 2015 in 17 wards of a general hospital and a residential facility of a northern Italian city. This study involved 213 nurses working in rotating night shifts and 65 in day shifts. The instrument used for data collection was the “Standard Shift Work Index,” validated in Italian. Data were statistically analyzed. Results The response rate was 86%. The nurses engaged in rotating night shifts were statistically significantly younger, more frequently single, and had Bachelors and Masters degrees in nursing. They reported the lowest mean score in the items of job satisfaction, quality and quantity of sleep, with more frequent chronic fatigue, psychological, and cardiovascular symptoms in comparison with the day shift workers, in a statistically significant way. Conclusion Our results suggest that nurses with rotating night schedule need special attention due to the higher risk for both job dissatisfaction and undesirable health effects. PMID:27695372

  8. Government policies promote deforestation

    SciTech Connect

    Not Available

    1988-09-01

    The well-documented loss of forest cover throughout the world has created a multitude of equally well-documented environmental problems, including soil erosion, water pollution, species extinctions, and the buildup of atmospheric carbon dioxide, a greenhouse gas that is contributing to global warming. Recent discussions on the causes of deforestation have focused on inevitable consequences of poverty and population growth, such as clearing for agricultural, shifting cultivation, and fuel-wood gathering. But according to a recent report from the World Resources Institute (WRI) in Washington, DC, another important often unrecognized, cause of deforestation is bad economic policies in the countries that own forest resources.

  9. WATER-GAS SHIFT KINETICS OVER IRON OXIDE CATALYSTS AT MEMBRANE REACTOR CONDITIONS

    SciTech Connect

    Carl R.F. Lund

    2002-08-02

    The kinetics of water-gas shift were studied over ferrochrome catalysts under conditions with high carbon dioxide partial pressures, such as would be expected in a membrane reactor. The catalyst activity is inhibited by increasing carbon dioxide partial pressure. A microkinetic model of the reaction kinetics was developed. The model indicated that catalyst performance could be improved by decreasing the strength of surface oxygen bonds. Literature data indicated that adding either ceria or copper to the catalyst as a promoter might impart this desired effect. Ceria-promoted ferrochrome catalysts did not perform any better than unpromoted catalyst at the conditions tested, but copper-promoted ferrochrome catalysts did offer an improvement over the base ferrochrome material. A different class of water-gas shift catalyst, sulfided CoMo/Al{sub 2}O{sub 3} is not affected by carbon dioxide and may be a good alternative to the ferrochrome system, provided other constraints, notably the requisite sulfur level and maximum temperature, are not too limiting. A model was developed for an adiabatic, high-temperature water-gas shift membrane reactor. Simulation results indicate that an excess of steam in the feed (three moles of water per mole of CO) is beneficial even in a membrane reactor as it reduces the rate of adiabatic temperature rise. The simulations also indicate that much greater improvement can be attained by improving the catalyst as opposed to improving the membrane. Further, eliminating the inhibition by carbon dioxide will have a greater impact than will increasing the catalyst activity (assuming inhibition is still operative). Follow-up research into the use of sulfide catalysts with continued kinetic and reactor modeling is suggested.

  10. Evaluating Outcomes of Electronic Tools Supporting Physician Shift-to-Shift Handoffs: A Systematic Review

    PubMed Central

    Davis, Joshua; Riesenberg, Lee Ann; Mardis, Matthew; Donnelly, John; Benningfield, Branden; Youngstrom, Mallory; Vetter, Imelda

    2015-01-01

    Background Multiple organizations have recognized that handoffs are prone to errors, and there has been an increase in the use of electronic health records and computerized tools in health care. Objective This systematic review evaluates the current evidence on the effectiveness of electronic solutions used to support shift-to-shift handoffs. Methods We searched the English-language literature for research studies published between January 1, 2008, and September 19, 2014, using National Library of Medicine PubMed, EBSCO CINAHL, OvidSP All Journals, and ProQuest PsycINFO. Included studies focused on the evaluation of physician shift-to-shift handoffs and an electronic solution designed to support handoffs. We assessed articles using a quality scoring system, conducted a review of barriers and strategies, and categorized study outcomes into self-report, process, and outcome measures. Results Thirty-seven articles met inclusion criteria, including 20 single group pre- and posttest studies; 8 posttest only or cross-sectional studies; 4 nonrandomized controlled trials; 1 cohort study; 1 randomized crossover study; and 3 qualitative studies. Quality scores ranged from 3.5 to 14 of a possible 16. Most articles documented some positive outcomes, with 2 of the 3 studies evaluating patient outcomes yielding statistically significant improvements. The only other study that analyzed patient outcomes showed that interventions other than the electronic tool were responsible for most of the significant improvements. Conclusions The majority of studies supported using an electronic tool, yet few measured patient outcomes, and numerous studies suffered from methodology issues. Future studies should evaluate patient outcomes, improve study design, assess the role of faculty oversight, and broaden the focus to recognize the role of human factors. PMID:26221430

  11. Model-based phase-shifting interferometer

    NASA Astrophysics Data System (ADS)

    Liu, Dong; Zhang, Lei; Shi, Tu; Yang, Yongying; Chong, Shiyao; Miao, Liang; Huang, Wei; Shen, Yibing; Bai, Jian

    2015-10-01

    A model-based phase-shifting interferometer (MPI) is developed, in which a novel calculation technique is proposed instead of the traditional complicated system structure, to achieve versatile, high precision and quantitative surface tests. In the MPI, the partial null lens (PNL) is employed to implement the non-null test. With some alternative PNLs, similar as the transmission spheres in ZYGO interferometers, the MPI provides a flexible test for general spherical and aspherical surfaces. Based on modern computer modeling technique, a reverse iterative optimizing construction (ROR) method is employed for the retrace error correction of non-null test, as well as figure error reconstruction. A self-compiled ray-tracing program is set up for the accurate system modeling and reverse ray tracing. The surface figure error then can be easily extracted from the wavefront data in forms of Zernike polynomials by the ROR method. Experiments of the spherical and aspherical tests are presented to validate the flexibility and accuracy. The test results are compared with those of Zygo interferometer (null tests), which demonstrates the high accuracy of the MPI. With such accuracy and flexibility, the MPI would possess large potential in modern optical shop testing.

  12. Shifts in color discrimination during early pregnancy.

    PubMed

    Orbán, Levente L; Dastur, Farhad N

    2012-05-25

    The present study explores two hypotheses: a) women during early pregnancy should experience increased color discrimination ability, and b) women during early pregnancy should experience shifts in subjective preference away from images of foods that appear either unripe or spoiled. Both of these hypotheses derive from an adaptive view of pregnancy sickness that proposes the function of pregnancy sickness is to decrease the likelihood of ingestion of foods with toxins or teratogens. Changes to color discrimination could be part of a network of perceptual and physiological defenses (e.g., changes to olfaction, nausea, vomiting) that support such a function. Participants included 13 pregnant women and 18 non-pregnant women. Pregnant women scored significantly higher than non-pregnant controls on the Farnsworth-Munsell (FM) 100 Hue Test, an objective test of color discrimination, although no difference was found between groups in preferences for food images at different stages of ripeness or spoilage. These results are the first indication that changes to color discrimination may occur during early pregnancy, and is consistent with the view that pregnancy sickness may function as an adaptive defense mechanism.

  13. Electrostatic shape-shifting ion optics

    DOEpatents

    Dahl, David A.; Scott, Jill R.; Appelhans, Anthony D.

    2006-05-02

    Electrostatic shape-shifting ion optics includes an outer electrode that defines an interior region between first and second opposed open ends. A first inner electrode is positioned within the interior region of the outer electrode at about the first open end. A second inner electrode is positioned within the interior region of the outer electrode at about the second open end. A first end cap electrode is positioned at about a first open end of the first inner electrode so that the first end cap electrode substantially encloses the first open end of the first inner electrode. A second end cap electrode is positioned at about a second open end of the second inner electrode so that the second end cap electrode substantially encloses the second open end of the second inner electrode. A voltage source operatively connected to each of the electrodes applies voltage functions to each of the electrodes to produce an electric field within an interior space enclosed by the electrodes.

  14. Measurement of isotope shifts in Fe II

    NASA Astrophysics Data System (ADS)

    Ascoli, Marco; Kawall, David; Eyler, Edward; Demille, David

    2006-05-01

    We describe absorption spectra of singly ionized iron (Fe II) obtained with a compact ion source and a high-resolution UV laser. Using a Nd:YAG laser ablation source and buffer gas cooling with room-temperature argon, Fe II ions are produced in a cold plasma. Grating spectroscopy is used to determine conditions favorable parameters providing good cooling and ion yield. This novel technique allows us to study the Fe II transition a ^6D9->z^6D^o9 with Doppler widths about 3 GHz, by measuring the absorption of a frequency-tripled pulse-amplified cw Ti:Sapphire laser. The isotope shift of this transition is important to the analysis of astronomical data on the cosmological evolution of the fine-structure constant α [1]. We will discus the design of the ion source and laser system, and present preliminary results. This study was funded by the National Science Foundation. 12 pt [1] J.K Webb,M.T. Murphy, V.V. Flambaum, V.A. Dzuba, J.D. Barrow, C.W. Churchill, J.X. Prochaska, and A.M. Wolfe, Phys. Rev. Lett. 87, 091301 (2001).

  15. Butterfly community shifts over two centuries.

    PubMed

    Habel, Jan Christian; Segerer, Andreas; Ulrich, Werner; Torchyk, Olena; Weisser, Wolfgang W; Schmitt, Thomas

    2016-08-01

    Environmental changes strongly impact the distribution of species and subsequently the composition of species assemblages. Although most community ecology studies represent temporal snap shots, long-term observations are rather rare. However, only such time series allow the identification of species composition shifts over several decades or even centuries. We analyzed changes in the species composition of a southeastern German butterfly and burnet moth community over nearly 2 centuries (1840-2013). We classified all species observed over this period according to their ecological tolerance, thereby assessing their degree of habitat specialisation. This classification was based on traits of the butterfly and burnet moth species and on their larval host plants. We collected data on temperature and precipitation for our study area over the same period. The number of species declined substantially from 1840 (117 species) to 2013 (71 species). The proportion of habitat specialists decreased, and most of these are currently endangered. In contrast, the proportion of habitat generalists increased. Species with restricted dispersal behavior and species in need of areas poor in soil nutrients had severe losses. Furthermore, our data indicated a decrease in species composition similarity between different decades over time. These data on species composition changes and the general trends of modifications may reflect effects from climate change and atmospheric nitrogen loads, as indicated by the ecological characteristics of host plant species and local changes in habitat configuration with increasing fragmentation. Our observation of major declines over time of currently threatened and protected species shows the importance of efficient conservation strategies.

  16. Measuring the entropy from shifted boundary conditions

    NASA Astrophysics Data System (ADS)

    Giusti, L.; Pepe, M.

    We explore a new computational strategy for determining the equation of state of the SU(3) Yang-Mills theory. By imposing shifted boundary conditions, the entropy density is computed from the vacuum expectation value of the off-diagonal components T_{0k} of the energy-momentum tensor. A step-scaling function is introduced to span a wide range in temperature values. We present preliminary numerical results for the entropy density and its step-scaling function obtained at eight temperature values in the range T_c - 15 T_c. At each temperature, discretization effects are removed by simulating the theory at several lattice spacings and by extrapolating the results to the continuum limit. Finite-size effects are always kept below the statistical errors. The absence of ultraviolet power divergences and the remarkably small discretization effects allow for a precise determination of the step-scaling function in the explored temperature range. These findings establish this strategy as a viable solution for an accurate determination of the equation of state in a wide range of temperature values.

  17. Scheduling Aircraft Landings under Constrained Position Shifting

    NASA Technical Reports Server (NTRS)

    Balakrishnan, Hamsa; Chandran, Bala

    2006-01-01

    Optimal scheduling of airport runway operations can play an important role in improving the safety and efficiency of the National Airspace System (NAS). Methods that compute the optimal landing sequence and landing times of aircraft must accommodate practical issues that affect the implementation of the schedule. One such practical consideration, known as Constrained Position Shifting (CPS), is the restriction that each aircraft must land within a pre-specified number of positions of its place in the First-Come-First-Served (FCFS) sequence. We consider the problem of scheduling landings of aircraft in a CPS environment in order to maximize runway throughput (minimize the completion time of the landing sequence), subject to operational constraints such as FAA-specified minimum inter-arrival spacing restrictions, precedence relationships among aircraft that arise either from airline preferences or air traffic control procedures that prevent overtaking, and time windows (representing possible control actions) during which each aircraft landing can occur. We present a Dynamic Programming-based approach that scales linearly in the number of aircraft, and describe our computational experience with a prototype implementation on realistic data for Denver International Airport.

  18. Advanced Water-Gas Shift Membrane Reactor

    SciTech Connect

    Sean Emerson; Thomas Vanderspurt; Susanne Opalka; Rakesh Radhakrishnan; Rhonda Willigan

    2009-01-07

    The overall objectives for this project were: (1) to identify a suitable PdCu tri-metallic alloy membrane with high stability and commercially relevant hydrogen permeation in the presence of trace amounts of carbon monoxide and sulfur; and (2) to identify and synthesize a water gas shift catalyst with a high operating life that is sulfur and chlorine tolerant at low concentrations of these impurities. This work successfully achieved the first project objective to identify a suitable PdCu tri-metallic alloy membrane composition, Pd{sub 0.47}Cu{sub 0.52}G5{sub 0.01}, that was selected based on atomistic and thermodynamic modeling alone. The second objective was partially successful in that catalysts were identified and evaluated that can withstand sulfur in high concentrations and at high pressures, but a long operating life was not achieved at the end of the project. From the limited durability testing it appears that the best catalyst, Pt-Re/Ce{sub 0.333}Zr{sub 0.333}E4{sub 0.333}O{sub 2}, is unable to maintain a long operating life at space velocities of 200,000 h{sup -1}. The reasons for the low durability do not appear to be related to the high concentrations of H{sub 2}S, but rather due to the high operating pressure and the influence the pressure has on the WGS reaction at this space velocity.

  19. Science Advocacy in a Shifting Policy Landscape

    NASA Astrophysics Data System (ADS)

    Bickford, E. E.

    2013-12-01

    In the last 50 years, federal investment in research as a share of total spending has declined from a little more than 10% in 1963 to less than 4% in 2013 (AAAS, 2013). In an era of sequestration and shrinking budgets, more and more scientists are advocating directly to policymakers (and their staff) to gain support for research programs and funding. The best advocates understand the political and policy processes, and anticipate policy shifts that may affect them. While scientists are trained with the technical skills to conduct their science, teach it to others, and market their work in order to win grants and publish papers, the policy advocacy arena is unfamiliar territory to many. Acquiring yet another area of expertise mid-career can be daunting, but science advocacy need not require another academic degree. Connecting with policymakers is the first step, and then an understanding of each policymaker's issue history and top priorities will inform the sales pitch. Here, I present some experiences on both the pitching and receiving ends of science advocacy from my year in the US Senate as an AGU/AAAS Congressional Science Fellow, and some guidance for meeting with policymakers and successful science advocacy.

  20. Sublithographic Architecture: Shifting the Responsibility for Perfection

    NASA Astrophysics Data System (ADS)

    Dehon, A.

    In the past, processing had orders of magnitude between devices and atoms (e.g., with silicon atom lattice spacing around 0.5 nm, a minimum size feature was roughly 2000 atoms wide when we had 1 μm feature sizes). It was the process engineer's job to craft this large collection of atoms into "perfect" devices. The circuit designer and architect could then design systems knowing the process engineer would always give them a set of perfect devices. As we continue to shrink our devices, we no longer have orders of magnitude between the devices and the atoms. As a result, the circuit designers and architects are beginning to work within a similar realm of atoms. Consequently, they must assume some of the responsibilities for dealing with atomic-scale imperfections and uncertainty. This demands a significant shift in our abstraction hierarchy, the responsibilities and expectations at each level in this hierarchy, our fabrication techniques, our testing strategies, and our approaches to design for these atomic-scale computing systems.

  1. Handedness: a neurogenetic shift of perspective.

    PubMed

    Ocklenburg, Sebastian; Beste, Christian; Güntürkün, Onur

    2013-12-01

    Handedness is the single most studied aspect of human brain asymmetries. For long it has been thought to be a monogenic trait that can produce an asymmetrical shift of cerebral mechanisms, thereby producing right handedness. Nevertheless, a single gene explaining a sufficient amount of phenotypic variance has not been identified. The results of several recent studies using advanced molecular genetic techniques suggest that a multifactorial model taking into account both multiple genetic and environmental factors, as well as their interactions, might be better suited to explain the complex processes underlying the ontogenesis of handedness. In this article, we review the new insights into handedness genetics provided by these studies and discuss, how integrating results from genetic and neuroscientific studies might help us to generate more accurate models of the ontogenesis of handedness. Based on these thoughts, we suggest several candidate gene groups (e.g. genes involved in the formation of the corpus callosum, asymmetrically expressed genes or genes involved in the development of structural left-right asymmetries) whose investigation would help to further understand the complex relation of genes, the brain and handedness.

  2. Developmental shifts and species selection in gastropods

    PubMed Central

    Duda, Thomas F.; Palumbi, Stephen R.

    1999-01-01

    The fossil record of marine gastropods has been used as evidence to support the operation of species selection; namely, that species with limited dispersal differentially increase in numbers because they are more likely to speciate than widely dispersing species. This conclusion is based on a tacit phylogenetic assumption that increases in species with limited dispersal are solely the result of speciation within monophyletic groups with low dispersal. To test this assumption, we reconstructed a phylogeny from nuclear sequence data for 70 species of the marine gastropod genus Conus and used it to map the evolution of developmental mode. All eight species without planktonic life history phases recently and independently evolved this characteristic from ancestors with planktonic larval phases, showing that transitions in developmental mode are common in this group. A simple model of species diversification shows that such shifts can control the relative numbers of species with and without dispersing larval stages, leading to apparent species selection. Such results challenge the conclusion that increases in the number of nonplanktonic species relative to species with planktonic larvae over geologic time is necessarily a result of higher rates of speciation of nonplanktonic lineages and show that demonstration of species selection requires a phylogenetic framework. PMID:10468598

  3. Health consequences of shift work and insufficient sleep.

    PubMed

    Kecklund, Göran; Axelsson, John

    2016-11-01

    This review summarises the literature on shift work and its relation to insufficient sleep, chronic diseases, and accidents. It is based on 38 meta-analyses and 24 systematic reviews, with additional narrative reviews and articles used for outlining possible mechanisms by which shift work may cause accidents and adverse health. Evidence shows that the effect of shift work on sleep mainly concerns acute sleep loss in connection with night shifts and early morning shifts. A link also exists between shift work and accidents, type 2 diabetes (relative risk range 1.09-1.40), weight gain, coronary heart disease (relative risk 1.23), stroke (relative risk 1.05), and cancer (relative risk range 1.01-1.32), although the original studies showed mixed results. The relations of shift work to cardiometabolic diseases and accidents mimic those with insufficient sleep. Laboratory studies indicate that cardiometabolic stress and cognitive impairments are increased by shift work, as well as by sleep loss. Given that the health and safety consequences of shift work and insufficient sleep are very similar, they are likely to share common mechanisms. However, additional research is needed to determine whether insufficient sleep is a causal pathway for the adverse health effects associated with shift work.

  4. An isotropic chemical shift-chemical shift anisotropic correlation experiment using discrete magic angle turning.

    PubMed

    Hu, Jian Zhi; Sears, Jesse A; Kwak, Ja Hun; Hoyt, David W; Wang, Yong; Peden, Charles H F

    2009-05-01

    An isotropic-anisotropic shift 2D correlation spectroscopy is introduced that combines the advantages of both magic angle turning (MAT) and magic angle hopping (MAH) technologies. In this new approach, denoted DMAT for "discrete magic angle turning", the sample rotates clockwise followed by an anticlockwise rotation of exactly the same amount with each rotation less or equal than 360 degrees but greater than 240 degrees , with the rotation speed being constant only for times related to the evolution dimension. This back and forth rotation is repeated and synchronized with a special radio frequency (RF) pulse sequence to produce an isotropic-anisotropic shift 2D correlation spectrum. For any spin-interaction of rank-2 such as chemical shift anisotropy, isotropic magnetic susceptibility interaction, and residual homo-nuclear dipolar interaction in biological fluid samples, the projection along the isotropic dimension is a high resolution spectrum. Since a less than 360 degrees sample rotation is involved, the design potentially allows for in situ control over physical parameters such as pressure, flow conditions, feed compositions, and temperature so that true in situ NMR investigations can be carried out.

  5. Frequency-shift vs phase-shift characterization of in-liquid quartz crystal microbalance applications

    SciTech Connect

    Montagut, Y. J.; Garcia, J. V.; Jimenez, Y.; Arnau, A.; March, C.; Montoya, A.

    2011-06-15

    The improvement of sensitivity in quartz crystal microbalance (QCM) applications has been addressed in the last decades by increasing the sensor fundamental frequency, following the increment of the frequency/mass sensitivity with the square of frequency predicted by Sauerbrey. However, this sensitivity improvement has not been completely transferred in terms of resolution. The decrease of frequency stability due to the increase of the phase noise, particularly in oscillators, made impossible to reach the expected resolution. A new concept of sensor characterization at constant frequency has been recently proposed. The validation of the new concept is presented in this work. An immunosensor application for the detection of a low molecular weight contaminant, the insecticide carbaryl, has been chosen for the validation. An, in principle, improved version of a balanced-bridge oscillator is validated for its use in liquids, and applied for the frequency shift characterization of the QCM immunosensor application. The classical frequency shift characterization is compared with the new phase-shift characterization concept and system proposed.

  6. A review of the consequences of fluid and electrolyte shifts in weightlessness

    NASA Technical Reports Server (NTRS)

    Leach, C. S.

    1979-01-01

    This review describes the renal-endocrine mechanisms related to the early losses of fluid-electrolytes from the body during weightlessness as well as their contribution to longer term adaptation of fluid-electrolyte balance. The hypotheses presented were generated by a systematic analysis of body fluid and renal dynamics observed under conditions of actual and simulated spaceflight. These have increased our understanding of the effects of acute headward fluid shifts on renal excretion, the factors promoting excess sodium excretion and the regulation of extracellular fluid composition.

  7. A review of the consequences of fluid and electrolyte shifts in weightlessness

    NASA Technical Reports Server (NTRS)

    Leach, C. S.

    1978-01-01

    This review describes the renal-endocrine mechanisms related to the early losses of fluid-electrolytes from the body during weightlessness as well as their contribution to longer term adaptation of fluid-electrolyte balance. The hypotheses presented were generated by a systematic analysis of body fluid and renal dynamics observed under conditions of actual and simulated spaceflight. These have increased our understanding of the effects of acute headward fluid shifts on renal excretion, the factors promoting excess sodium excretion and the regulation of extracellular fluid composition.

  8. Academic--practice partnerships in practice research: A cultural shift for health social workers.

    PubMed

    Joubert, Lynette

    2006-01-01

    Academic practice partnerships in practice research support health social workers in engaging in research that is embedded within their practice. This shift in culture enables social workers to join in a health service discourse that is increasingly data -driven and focused on effective practice and demonstrated quality of care for patients. The mentoring model is described as enabling practitioners to superimpose research skills onto existing practice skills. An academic practice research collaboration can reduce the distance between research and practice, contribute to a body of knowledge for health social work and promote health social workers as 'research focused practitioners'.

  9. Characterization of Microbial Population Shifts during Sample Storage.

    PubMed

    Mills, Heath J; Reese, Brandi Kiel; Peter, Cruz St

    2012-01-01

    The objective of this study was to determine shifts in the microbial community structure and potential function based on standard Integrated Ocean Drilling Program (IODP) storage procedures for sediment cores. Standard long-term storage protocols maintain sediment temperature at 4°C for mineralogy, geochemical, and/or geotechnical analysis whereas standard microbiological sampling immediately preserves sediments at -80°C. Storage at 4°C does not take into account populations may remain active over geologic time scales at temperatures similar to storage conditions. Identification of active populations within the stored core would suggest geochemical and geophysical conditions within the core change over time. To test this potential, the metabolically active fraction of the total microbial community was characterized from IODP Expedition 325 Great Barrier Reef sediment cores prior to and following a 3-month storage period. Total RNA was extracted from complementary 2, 20, and 40 m below sea floor sediment samples, reverse transcribed to complementary DNA and then sequenced using 454 FLX sequencing technology, yielding over 14,800 sequences from the six samples. Interestingly, 97.3% of the sequences detected were associated with lineages that changed in detection frequency during the storage period including key biogeochemically relevant lineages associated with nitrogen, iron, and sulfur cycling. These lineages have the potential to permanently alter the physical and chemical characteristics of the sediment promoting misleading conclusions about the in situ biogeochemical environment. In addition, the detection of new lineages after storage increases the potential for a wider range of viable lineages within the subsurface that may be underestimated during standard community characterizations.

  10. Soybean GH3 promoter contains multiple auxin-inducible elements.

    PubMed Central

    Liu, Z B; Ulmasov, T; Shi, X; Hagen, G; Guilfoyle, T J

    1994-01-01

    The soybean GH3 gene is transcriptionally induced in a wide variety of tissues and organs within minutes after auxin application. To determine the sequence elements that confer auxin inducibility to the GH3 promoter, we used gel mobility shift assays, methylation interference, deletion analysis, linker scanning, site-directed mutagenesis, and gain-of-function analysis with a minimal cauliflower mosaic virus 35S promoter. We identified at least three sequence elements within the GH3 promoter that are auxin inducible and can function independently of one another. Two of these elements are found in a 76-bp fragment, and these consist of two independent 25- and 32-bp auxin-inducible elements. Both of these 25- and 32-bp auxin-inducible elements contain the sequence TGTCTC just upstream of an AATAAG. An additional auxin-inducible element was found upstream of the 76-bp auxin-inducible fragment; this can function independently of the 76-bp fragment. Two TGA-box or Hex-like elements (TGACGTAA and TGACGTGGC) in the promoter, which are strong binding sites for proteins in plant nuclear extracts, may also elevate the level of auxin inducibility of the GH3 promoter. The multiple auxin-inducible elements within the GH3 promoter contribute incrementally to the overall level of auxin induction observed with this promoter. PMID:8038604

  11. Exploring Australian health promotion and environmental sustainability initiatives.

    PubMed

    Patrick, Rebecca; Kingsley, Jonathan

    2016-04-01

    Issue addressed Health promotion practitioners have important roles in applying ecosystem approaches to health and actively promoting environmental sustainability within community-level practice. The present study identified the nature and scope of health promotion activities across Australia that tackle environmental sustainability. Methods A mixed-method approach was used, with 82 participants undertaking a quantitative survey and 11 undertaking a qualitative interview. Purposeful sampling strategies were used to recruit practitioners who were delivering community-level health promotion and sustainability programs in Australia. The data were analysed thematically and interpretation was guided by the principles of triangulation. Results Study participants were at various stages of linking health promotion and environmental sustainability. Initiatives focused on healthy and sustainable food, active transport, energy efficiency, contact with nature and capacity building. Conclusion Capacity building approaches were perceived as essential to strengthening this field of practice. Healthy and sustainable food and active transport were suitable platforms for simultaneously promoting community health and sustainability. There was potential for expansion of programs that emphasise contact with nature and energy issues, as well as interventions that emphasise systems thinking and interdisciplinary approaches. So what? It was promising that Australian health promotion programs have started to address complexity rather than single issues, as evidenced by explicit engagement with environmental sustainability. However, more effort is required to enable a shift towards ecosystem approaches to health.

  12. The promotion of breastfeeding.

    PubMed

    Tuluhungwa, R R; Yung, W

    1979-01-01

    To reverse the current trend of a significant decline worldwide in breast feeding means reeducation of medical and health personnel as well as the general public. Programs to promote breast feeding require the commitment of governments, with support from various ministries including health, education, labor, community development and judiciary. Examples of what 3 developing countries--Jamaica, Colombia and Thailand--are doing to promote breast feeding are reported. A large scale breast feeding campaign was launched in Jamaica in October 1977. The 3 phases of the campaign were: 1) preliminary surveys and research and motivation of professional, voluntary and extension groups through training seminars, panel discussions, and meetings; 2) promotion of breast feeding via mass media and motivation of target groups by trained personnel; and 3) evaluation of the campaign. A survey undertaken in 1978 showed that the breast feeding messages had achieved the desired effect--more mothers practiced breast feeding. In Colombia the breast feeding campaign emphasized non-formal education through the use of games and pictures. A game is used which is usually initiated by a health worker in the waiting room of a health center and involves the mothers, the general public, and sometimes the professional personnel. Through reading and interpreting rhymed breast feeding messages, the participants exchange opinions and experiences. Before starting a campaign to encourage low-income urban and semi-urban mothers to breast feed, the National Food and Nutrition Committee of Thailand pretested slogans and posters designed for the promotion of breast feeding. Posters develpoed in accordance with the suggestions made by the women were tested among 126 pregnant and lactating women. The Committee decided which picture to print for low-income and rural audiences and which to print for middle-class audiences.

  13. Democracy Promotion in Oman

    DTIC Science & Technology

    2013-01-01

    succession process . The “Ruling Family Council” will meet to designate a successor within 3 days of Qaboos’s death. If it fails to select someone, it will...the Gulf is to increase democracy promotion programs designed to encourage timely and peaceful transitions to more representative forms of govern...stronger efforts toward reform supported by the United States could foster a more peaceful political transformation. This process should begin with the

  14. Publishing and academic promotion.

    PubMed

    Dixon, A K

    2009-09-01

    Clearly, academic endeavour has to be the single most important criterion for appointment to an academic position and for subsequent promotion. It is rare for excellence either in teaching or clinical practice to offset a poor publication record. However, the pressure to publish and gain related grant income can lead to problems in the normal academic pursuits of a department or institution. These and other related issues will be explored in this editorial.

  15. Bicycle Promotion Plan

    SciTech Connect

    Simone, G. A.

    1981-03-09

    The objective of this Bicycle Promotion Plan is to outline a set of recommendations and supporting strategies for implementation by the US DOE toward increased use of the bicycle for energy conservation. The recommendations are designed in such a way as to function in concert with: (1) bicycle programs administered by other Federal government agencies; and (2) related programs and activities already sponsored by DOE. The approach to preparation of the Plan involved a review of all current and planned bicycle promotion programs at the Federal level as well as a review of the array of lierature on the subject. The UniWorld project staff also interacted with several DOE program offices, in order to determine the extent to which they might appropriately contribute to the implementation of bicycle promotional efforts. A synthesis of all the information gathered was published in January of 1981 as a part of the project (The Bicycle Program Review). Based upon this information and an examination of the barriers to bicycle use identified by bicycle transportation specialists in the field, UniWorld developed a series of the most potentially effective recommendations and program strategies for implementation by DOE. The recommendations address activities that could be undertaken in conjunction with existing DOE programs, new developments that might be considered to fulfill critical needs in the field, and interagency efforts that DOE could play a role in.

  16. Nonlinear Pressure Shifts of Rubidium in Inert Gases

    NASA Astrophysics Data System (ADS)

    McGuyer, Bart; Jau, Yuan-Yu; Happer, William

    2009-05-01

    Vapor-cell atomic frequency standards are based on the hyperfine (microwave) magnetic-resonance frequencies of optically pumped alkali-metal atoms in inert buffer gas. Through the hyperfine-shift interaction, buffer gas induces pressure shift and broadening in these microwave resonances. Previous work uncovered nonlinear dependence in the pressure shifts of ^87Rb and Cs atoms to the pressure of buffer gases Ar and Kr, but not He or N2. The nonlinearity is thought to result from alteration to the hyperfine-shift interaction due to temporary van der Waals molecules formed between alkali-metal and buffer-gas atoms. We investigate nonlinear pressure shifts for both isotopes of Rb, ^87Rb and ^85Rb. This study will test the current model for nonlinear pressure shifts of alkali metals in inert gases.

  17. Twelve-hour shift on ITU: a nursing evaluation.

    PubMed

    Richardson, Annette; Dabner, Nichola; Curtis, Sarah

    2003-01-01

    This paper describes the introduction and subsequent evaluation of a 12-h shift system in a large ITU in the northeast of UK. To date, only a small number of studies has evaluated nurses working the 12-h shifts in critical care areas. To evaluate the level of staff satisfaction, data were collected by means of a questionnaire involving 41 nurses, at 3 months following the introduction of the 12-h shifts. The responses from the evaluation advocated the continuation of 12-h shifts with alternative shift patterns for nurses who felt dissatisfied with the current system. Twelve-hour shifts can be seen as a flexible system for nurses working in intensive care and may assist with staff satisfaction and improving nurse recruitment and retention.

  18. Shift Work and Sleep Quality Among Urban Police Officers

    PubMed Central

    Fekedulegn, Desta; Burchfiel, Cecil M.; Charles, Luenda E.; Hartley, Tara A.; Andrew, Michael E.; Violanti, John M.

    2016-01-01

    Objective The aim of the study was to examine association of shift work with sleep quality in police officers. Methods Data were obtained from the Buffalo Cardio-Metabolic Occupational Police Stress study (n =363). An electronic work history database was used to define shift as day, afternoon, or night for three durations: past month, 1 year, and 15 years. Sleep quality was determined using the Pittsburgh Sleep Quality Index. Results The overall prevalence of poor sleep quality was 54%; 44% for day, 60% for afternoon, and 69% for night shift. Poor sleep quality was 70% more prevalent among night-shift officers (P <0.001) and 49% higher among those on the afternoon shift (P =0.003) relative to officers working on the day shift. Conclusions Night and evening work schedules are associated with elevated prevalence of poor sleep quality among police officers. PMID:26949891

  19. Anomalous Knight Shift properties in a variety of Superconductors

    NASA Astrophysics Data System (ADS)

    Hall, Bianca; Klemm, Richard

    2014-03-01

    Anomalous Knight shift properties have been found in a variety of superconductors below the superconducting transition temperature. In most instances this anomaly is an observed Knight shift along one axis but no observed Knight shift perpendicular to this axis (usually the c-axis). Materials that show this anomaly include LiFeAs, UPt3, CeTIn5 (T =Co and Ir), Tl2Ba2CuO6 +y, and YBa2Cu3O7- δ. Another anomaly occurs in the material Na0.35CoO2 .1.3H2O, where NMR data for the Knight shift done on 59Co and 23Na do not agree. Additionally, NMR data of FeSe show no shift, which is contrary to the material's s-wave pairing superconductivity. Finally, Sr2RuO4 has a constant Knight shift, which is contrary to upper critical field measurements and superconducting gap measurements.

  20. Spatial phase-shifting characteristic of double grating interferometer.

    PubMed

    Song, Yang; Chen, Yunyun; He, Anzhi; Zhao, Zhimin

    2009-10-26

    Double grating interferometer is usually used to achieve phase information from distorted wave front by its temporal phase-shifting characteristic. In this paper, the spatial phase-shifting characteristic of double grating interferometer is presented. The explicit intensity distributions of interferograms produced by double gratings are derived with the scalar diffraction theory, and the stable phase shift is found between plus-first, zero and minus-first order interferograms. Results indicate that the phase shift only depends on the grating period and the distance between two gratings if no phase object exists. If phase object exists, it varies on the interferograms. But the phase shifts are equal at any special point of interferograms. In particular, the triple grating interferometer is presented to generate at least four phase shift interferograms simultaneously with the similar method.

  1. The dynamics of mobile promoters: Enhanced stability in promoter regions.

    PubMed

    Rabbani, Mahnaz; Wahl, Lindi M

    2016-10-21

    Mobile promoters are emerging as a new class of mobile genetic elements, first identified by examining prokaryote genome sequences, and more recently confirmed by experimental observations in bacteria. Recent datasets have identified over 40,000 putative mobile promoters in sequenced prokaryote genomes, however only one-third of these are in regions of the genome directly upstream from coding sequences, that is, in promoter regions. The presence of many promoter sequences in non-promoter regions is unexplained. Here we develop a general mathematical model for the dynamics of mobile promoters, extending previous work to capture the dynamics both within and outside promoter regions. From this general model, we apply rigorous model selection techniques to identify which parameters are statistically justified in describing the available mobile promoter data, and find best-fit values of these parameters. Our results suggest that high rates of horizontal gene transfer maintain the population of mobile promoters in promoter regions, and that once established at these sites, mobile promoters are rarely lost, but are commonly copied to other genomic regions. In contrast, mobile promoter copies in non-promoter regions are more numerous and more volatile, experiencing substantially higher rates of duplication, loss and diversification.

  2. Human Promoters Are Intrinsically Directional

    PubMed Central

    Duttke, Sascha H.C.; Lacadie, Scott A.; Ibrahim, Mahmoud M.; Glass, Christopher K.; Corcoran, David L.; Benner, Christopher; Heinz, Sven; Kadonaga, James T.; Ohler, Uwe

    2015-01-01

    Divergent transcription, in which reverse-oriented transcripts occur upstream of eukaryotic promoters in regions devoid of annotated genes, has been suggested to be a general property of active promoters. Here we show that the human basal RNA polymerase II transcriptional machinery and core promoter are inherently unidirectional, and that reverse-oriented transcripts originate from their own cognate reverse-directed core promoters. In vitro transcription analysis and mapping of nascent transcripts in cells revealed that sequences at reverse start sites are similar to those of their forward counterparts. The use of DNase I accessibility to define proximal promoter borders revealed that up to half of promoters are unidirectional and that unidirectional promoters are depleted at their upstream edges of reverse core promoter sequences and their associated chromatin features. Divergent transcription is thus not an inherent property of the transcription process, but rather the consequence of the presence of both forward- and reverse-directed core promoters. PMID:25639469

  3. Validation of a Cephalad Fluid Shift Countermeasure

    NASA Technical Reports Server (NTRS)

    Macias, B.; Cole, C.; Kesari, S.; Hargens, A.; Stenger, M.; Ebert, D.; Lee, S. M. C.; Sargsyan, A.; Liu, J.

    2016-01-01

    INTRODUCTION: This project will provide critical data required to objectively determine how an optimized thigh cuff could be incorporated into the NASA integrated physiological countermeasure suite. This project will determine if thigh cuffs used during simulated spaceflight impact intracranial pressure (ICP), ocular structure and function, and intraocular pressure (IOP) using state of-the-art techniques. Additionally, some of the same methods, hardware, and protocols will be employed in the present investigation to enable direct comparisons to the International Space Station (ISS) "Fluid Shifts" experiment with Chibis-Lower Body Negative Pressure (LBNP). This study will determine the temporal physiological responses of thigh cuff application and removal on ocular and cerebral variables (including invasive ICP) in a microgravity analog. Furthermore, this proposed study will determine tissue pressure distribution applied by thigh cuffs in order to improve comfort, mobility, and efficacy of the countermeasure. Our specific aim is to determine the efficacy of a novel thigh cuff device to mitigate cephalad fluid shifts. We hypothesize that a thigh cuff countermeasure employed in a microgravity analog will temporarily reverse or attenuate ocular and cerebral-volume-pressure variables, approaching normal Earth-based seated posture, the most frequent posture assumed in daily life. In addition, we hypothesize that the magnitude of fluid and pressure redistribution using a thigh cuff countermeasure may require a longer exposure time than that of Chibis-LBNP (using ground-based data from our "Fluid Shifts" project). This project directly addresses Critical Path Roadmap Risks and Questions regarding "Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations," and IRP Gap VIIP13: We need to identify preventative and treatment countermeasures to mitigate changes in ocular structure and function and intracranial pressure during spaceflight. METHODS: Noninvasive

  4. Etched-multilayer phase shifting masks for EUV lithography

    DOEpatents

    Chapman, Henry N.; Taylor, John S.

    2005-04-05

    A method is disclosed for the implementation of phase shifting masks for EUV lithography. The method involves directly etching material away from the multilayer coating of the mask, to cause a refractive phase shift in the mask. By etching into the multilayer (for example, by reactive ion etching), rather than depositing extra material on the top of the multilayer, there will be minimal absorption loss associated with the phase shift.

  5. Synchronous marine pelagic regime shifts in the Northern Hemisphere

    PubMed Central

    Beaugrand, G.; Conversi, A.; Chiba, S.; Edwards, M.; Fonda-Umani, S.; Greene, C.; Mantua, N.; Otto, S. A.; Reid, P. C.; Stachura, M. M.; Stemmann, L.; Sugisaki, H.

    2015-01-01

    Regime shifts are characterized by sudden, substantial and temporally persistent changes in the state of an ecosystem. They involve major biological modifications and often have important implications for exploited living resources. In this study, we examine whether regime shifts observed in 11 marine systems from two oceans and three regional seas in the Northern Hemisphere (NH) are synchronous, applying the same methodology to all. We primarily infer marine pelagic regime shifts from abrupt shifts in zooplankton assemblages, with the exception of the East Pacific where ecosystem changes are inferred from fish. Our analyses provide evidence for quasi-synchronicity of marine pelagic regime shifts both within and between ocean basins, although these shifts lie embedded within considerable regional variability at both year-to-year and lower-frequency time scales. In particular, a regime shift was detected in the late 1980s in many studied marine regions, although the exact year of the observed shift varied somewhat from one basin to another. Another regime shift was also identified in the mid- to late 1970s but concerned less marine regions. We subsequently analyse the main biological signals in relation to changes in NH temperature and pressure anomalies. The results suggest that the main factor synchronizing regime shifts on large scales is NH temperature; however, changes in atmospheric circulation also appear important. We propose that this quasi-synchronous shift could represent the variably lagged biological response in each ecosystem to a large-scale, NH change of the climatic system, involving both an increase in NH temperature and a strongly positive phase of the Arctic Oscillation. Further investigation is needed to determine the relative roles of changes in temperature and atmospheric pressure patterns and their resultant teleconnections in synchronizing regime shifts at large scales.

  6. Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

    PubMed

    Papagiannakopoulos, Thales; Bauer, Matthew R; Davidson, Shawn M; Heimann, Megan; Subbaraj, Lakshmipriya; Bhutkar, Arjun; Bartlebaugh, Jordan; Vander Heiden, Matthew G; Jacks, Tyler

    2016-08-09

    Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Using a genetically engineered mouse model of lung adenocarcinoma, we have characterized the effects of circadian rhythm disruption on lung tumorigenesis. We demonstrate that both physiologic perturbation (jet lag) and genetic mutation of the central circadian clock components decreased survival and promoted lung tumor growth and progression. The core circadian genes Per2 and Bmal1 were shown to have cell-autonomous tumor-suppressive roles in transformation and lung tumor progression. Loss of the central clock components led to increased c-Myc expression, enhanced proliferation, and metabolic dysregulation. Our findings demonstrate that both systemic and somatic disruption of circadian rhythms contribute to cancer progression.

  7. Assessment of the pivot shift using inertial sensors.

    PubMed

    Zaffagnini, Stefano; Signorelli, Cecilia; Grassi, Alberto; Yue, Han; Raggi, Federico; Urrizola, Francisco; Bonanzinga, Tommaso; Marcacci, Maurilio

    2016-06-01

    The pivot shift test is an important clinical tool used to assess the stability of the knee following an injury to the anterior cruciate ligament (ACL). Previous studies have shown that significant variability exists in the performance and interpretation of this manoeuvre. Accordingly, a variety of techniques aimed at standardizing and quantifying the pivot shift test have been developed. In recent years, inertial sensors have been used to measure the kinematics of the pivot shift. The goal of this study is to present a review of the literature and discuss the principles of inertial sensors and their use in quantifying the pivot shift test.

  8. Binding Affinities Controlled by Shifting Conformational Equilibria: Opportunities and Limitations

    PubMed Central

    Michielssens, Servaas; de Groot, Bert L.; Grubmüller, Helmut

    2015-01-01

    Conformational selection is an established mechanism in molecular recognition. Despite its power to explain binding events, it is hardly used in protein/ligand design to modulate molecular recognition. Here, we explore the opportunities and limitations of design by conformational selection. Using appropriate thermodynamic cycles, our approach predicts the effects of a conformational shift on binding affinity and also allows one to disentangle the effects induced by a conformational shift from other effects influencing the binding affinity. The method is assessed and applied to explain the contribution of a conformational shift on the binding affinity of six ubiquitin mutants showing different conformational shifts in six different complexes. PMID:25992736

  9. A scoping study on task shifting; the case of Uganda

    PubMed Central

    2014-01-01

    Background Task shifting has been implemented in Uganda for decades with little documentation. This study’s objectives were to; gather evidence on task-shifting experiences in Uganda, establish its acceptability and perceptions among health managers and policymakers, and make recommendations. Methods This was a qualitative study. Data collection involved; review of published and gray literature, and key informant interviews of stakeholders in health policy and decision making in Uganda. Data was analyzed by thematic content analysis. Results Task shifting was the mainstay of health service delivery in Uganda. Lower cadre of health workers performed duties of specialized health workers. However, Uganda has no task shifting policy and guidelines, and task shifting was practiced informally. Lower cadre of health workers were deemed to be incompetent to handle shifted roles and already overworked, and support supervision was poor. Advocates of task shifting argued that lower cadre of health workers already performed the roles of highly trained health workers. They needed a supporting policy and support supervision. Opponents argued that lower cadre of health workers were; incompetent, overworked, and task shifting was more expensive than recruiting appropriately trained health workers. Conclusions Task shifting was unacceptable to most health managers and policy makers because lower cadres of health workers were; incompetent, overworked and support supervision was poor. Recruitment of existing unemployed well trained health workers, implementation of human resource motivation and retention strategies, and government sponsored graduates to work for a defined mandatory period of time were recommended. PMID:24754917

  10. Generalized phase-shifting digital holography for single-exposure

    NASA Astrophysics Data System (ADS)

    Nomura, Takanori; Imbe, Masatoshi

    2015-07-01

    Single exposure phase-shifting digital holography is mandatory for recording/analyzing dynamic phenomena. As one of the candidate for the single exposure phase-shifting digital holography is the wave-splitting phase-shifting digital holography. We have proposed generalized phase-shifting digital holography as one of the wave-splitting phase-shifting digital holography. In the digital holography, the phase-shift quantity, which corresponds to the difference between the phase quantities of the reference wave on the adjacent pixels is generalized different from ordinal wave-splitting methods. Owing to the generalized phase-shifting, we can use a random-phase wave as the reference wave. The proposed phase-shifting digital holography enables us to record a fully-complex field of a dynamic phenomena without dc and conjugate terms using a commercially available optical devices. The relation between the property of the reference wave and the quality of the reconstructed images are discussed. Experimental results are given to confirm the proposed phase-shifting digital holography.

  11. Protonated alcohols are examples of complete charge-shift bonds.

    PubMed

    Anderson, Peter; Petit, Alban; Ho, Junming; Mitoraj, Mariusz Pawel; Coote, Michelle L; Danovich, David; Shaik, Sason; Braïda, Benoît; Ess, Daniel H

    2014-11-07

    Accurate gas-phase and solution-phase valence bond calculations reveal that protonation of the hydroxyl group of aliphatic alcohols transforms the C-O bond from a principally covalent bond to a complete charge-shift bond with principally "no-bond" character. All bonding in this charge-shift bond is due to resonance between covalent and ionic structures, which is a different bonding mechanism from that of traditional covalent bonds. Until now, charge-shift bonds have been previously identified in inorganic compounds or in exotic organic compounds. This work showcases that charge-shift bonds can occur in common organic species.

  12. Global regime shift dynamics of catastrophic sea urchin overgrazing

    PubMed Central

    Ling, S. D.; Scheibling, R. E.; Rassweiler, A.; Johnson, C. R.; Shears, N.; Connell, S. D.; Salomon, A. K.; Norderhaug, K. M.; Pérez-Matus, A.; Hernández, J. C.; Clemente, S.; Blamey, L. K.; Hereu, B.; Ballesteros, E.; Sala, E.; Garrabou, J.; Cebrian, E.; Zabala, M.; Fujita, D.; Johnson, L. E.

    2015-01-01

    A pronounced, widespread and persistent regime shift among marine ecosystems is observable on temperate rocky reefs as a result of sea urchin overgrazing. Here, we empirically define regime-shift dynamics for this grazing system which transitions between productive macroalgal beds and impoverished urchin barrens. Catastrophic in nature, urchin overgrazing in a well-studied Australian system demonstrates a discontinuous regime shift, which is of particular management concern as recovery of desirable macroalgal beds requires reducing grazers to well below the initial threshold of overgrazing. Generality of this regime-shift dynamic is explored across 13 rocky reef systems (spanning 11 different regions from both hemispheres) by compiling available survey data (totalling 10 901 quadrats surveyed in situ) plus experimental regime-shift responses (observed during a total of 57 in situ manipulations). The emergent and globally coherent pattern shows urchin grazing to cause a discontinuous ‘catastrophic’ regime shift, with hysteresis effect of approximately one order of magnitude in urchin biomass between critical thresholds of overgrazing and recovery. Different life-history traits appear to create asymmetry in the pace of overgrazing versus recovery. Once shifted, strong feedback mechanisms provide resilience for each alternative state thus defining the catastrophic nature of this regime shift. Importantly, human-derived stressors can act to erode resilience of desirable macroalgal beds while strengthening resilience of urchin barrens, thus exacerbating the risk, spatial extent and irreversibility of an unwanted regime shift for marine ecosystems.

  13. Mitigating Doppler shift effect in HF multitone data modem

    NASA Astrophysics Data System (ADS)

    Sonlu, Yasar

    1989-09-01

    Digital communications over High Frequency (HF) radio channels are getting important in recent years. Current HF requirements are for data transmission at rates 2.4 kbps or more to accommodate computer data links and digital secure voice. HF modems which were produced to meet these speeds are, serial modems and parallel modems. On the other hand, the HF sky-wave communication medium, the ionosphere, has some propagation problems such as multipath and Doppler shift. The effect of Doppler shift in a parallel modem which employs Differential Quadrature Phase Shift Keying (DQPSK) modulation is considered and a correction method to mitigate the Doppler Shift effect is introduced.

  14. Plate motion and the secular shift of the mean pole

    NASA Technical Reports Server (NTRS)

    Liu, H.; Carpenter, L.; Agreen, R. W.

    1973-01-01

    The global plate motion indicates that changes in the products of inertia of the earth due to tectonic plate movement may provide a secular shift of the mean pole. A mathematical procedure for calculating this shift based on the plate theory is presented. Explicit expressions were obtained for the dependence of the secular polar shift on the dimensions and locations of the plate boundaries. Numerical results show that the secular motion of the mean pole is 0.0002 sec/year in the direction of 67 W. Hence, it is deduced that the influence of the plate motion on the secular polar shift may account for 10% of the observed value.

  15. Competition between the tensor light shift and nonlinear Zeeman effect

    SciTech Connect

    Chalupczak, W.; Wojciechowski, A.; Pustelny, S.; Gawlik, W.

    2010-08-15

    Many precision measurements (e.g., in spectroscopy, atomic clocks, quantum-information processing, etc.) suffer from systematic errors introduced by the light shift. In our experimental configuration, however, the tensor light shift plays a positive role enabling the observation of spectral features otherwise masked by the cancellation of the transition amplitudes and creating resonances at a frequency unperturbed either by laser power or beam inhomogeneity. These phenomena occur thanks to the special relation between the nonlinear Zeeman and light shift effects. The interplay between these two perturbations is systematically studied and the cancellation of the nonlinear Zeeman effect by the tensor light shift is demonstrated.

  16. Shift work at a modern offshore drilling rig.

    PubMed

    Rodrigues, V F; Fischer, F M; Brito, M J

    2001-12-01

    The oil and gas exploration and production offshore units are classified as hazardous installations. Work in these facilities is complex, confined and associated with a wide range of risks. The continuous operation is secured by various shift work patterns. The objective of this study was to evaluate how offshore drilling workers perceived shift work at high seas and its impacts on their life and working conditions. The main features of the studied offshore shift work schedules are: long time on board (14 to 28 days), extended shifts (12 hours or more per day), slow rotation (7 to 14 days in the same shift), long sequence of days on the night shift (7 to 14 days in a row) and the extra-long extended journey (18 hours) on shift change and landing days. Interviews revealed a wide range of stressors caused by the offshore shift work, as well as difficulties to conciliate work with family life. It was observed that changes of the family model, leading to role conflicts and social isolation, work in a hazardous environment, perceiving poor sleep when working at night shifts and the imbalance between the expected and actual rewards are the major stressors for the offshore drilling workers.

  17. Marine regime shifts: drivers and impacts on ecosystems services

    PubMed Central

    Rocha, J.; Yletyinen, J.; Biggs, R.; Blenckner, T.; Peterson, G.

    2015-01-01

    Marine ecosystems can experience regime shifts, in which they shift from being organized around one set of mutually reinforcing structures and processes to another. Anthropogenic global change has broadly increased a wide variety of processes that can drive regime shifts. To assess the vulnerability of marine ecosystems to such shifts and their potential consequences, we reviewed the scientific literature for 13 types of marine regime shifts and used networks to conduct an analysis of co-occurrence of drivers and ecosystem service impacts. We found that regime shifts are caused by multiple drivers and have multiple consequences that co-occur in a non-random pattern. Drivers related to food production, climate change and coastal development are the most common co-occurring causes of regime shifts, while cultural services, biodiversity and primary production are the most common cluster of ecosystem services affected. These clusters prioritize sets of drivers for management and highlight the need for coordinated actions across multiple drivers and scales to reduce the risk of marine regime shifts. Managerial strategies are likely to fail if they only address well-understood or data-rich variables, and international cooperation and polycentric institutions will be critical to implement and coordinate action across the scales at which different drivers operate. By better understanding these underlying patterns, we hope to inform the development of managerial strategies to reduce the risk of high-impact marine regime shifts, especially for areas of the world where data are not available or monitoring programmes are not in place.

  18. Observation of Goos-Hänchen shifts in metallic reflection.

    PubMed

    Merano, M; Aiello, A; 't Hooft, G W; van Exter, M P; Eliel, E R; Woerdman, J P

    2007-11-26

    We report the first observation of the Goos-Hänchen shift of a light beam incident on a bare metal surface. This phenomenon is particularly interesting because the Goos-Hänchen shift for p polarized light in metals is negative and much bigger than the positive shift for s polarized light. The experimental result for the measured shifts as a function of the angle of incidence is in excellent agreement with theoretical predictions. In an energy-flux interpretation, our measurement shows the existence of a backward energy flow at the bare metal surface when this is excited by a p polarized beam of light.

  19. Hydrogenic Lamb shift in iron Fe{sup 25+} and fine-structure Lamb shift

    SciTech Connect

    Chantler, C. T.; Laming, J. M.; Dietrich, D. D.; Hallett, W. A.; McDonald, R.; Silver, J. D.

    2007-10-15

    1s-2p Lyman {alpha} transitions in hydrogenic iron Fe{sup 25+} have been observed from a beam-foil source in fourth-order diffraction off ADP 101 and PET 002 crystals, simultaneously with the n=2 to n=4 Balmer {beta} transitions diffracted in first order. Calibration of the local dispersion relation of the spectrometer using Balmer {beta} lines provides measurements of Lyman {alpha} wavelengths. The approach of fitting the full two-dimensional dispersion relation, including other members of Balmer and Lyman series, limits random and systematic correlation of parameters, and reveals a major systematic due to dynamical diffraction depth penetration into a curved crystal. The development of a theory of x-ray diffraction from mosaic crystals was necessary for the accurate interpretation of the experimental data. Photographic theory was also developed in the process of this research. Several systematics are discussed and quantified for the first time for these medium-Z QED comparisons. 2s-1s and 4f-2p satellites are explicitly investigated, and a dominant systematic is uncovered, which is due to the variable location of spectral emission downstream of the beam-foil target. 1s-2p{sub 3/2}, 1s-2p{sub 1/2} iron Lamb shifts are measured to be 35 376{+-}1900 cm{sup -1} and 35 953{+-}1800 cm{sup -1}. These agree with but lie higher than theory. This represents a 5.7% measurement of the hydrogenic 1s-2p{sub 1/2} Lamb shift in iron. The technique also reports the iron 2p{sub 3/2}-2p{sub 1/2} fine structure as 171 108 cm{sup -1}{+-}180 cm{sup -1}, which represents a 51% measurement of the hydrogenic iron fine-structure Lamb shift, and reports measurements of secondary lines.

  20. Shift in power to hospital accountants.

    PubMed

    Rayburn, L G; Rayburn, J M

    1996-01-01

    With the introduction of the Prospective Payment System, hospital accountants' role changed from reimbursement maximizers to an important role in decision making. Faced with increased competition, many hospitals are installing financial controls. Many hospitals are engaging in promotion and health awareness campaigns and expanding their services to stabilize income and reduce the effects of a changing environment. Thus, hospitals operate in a more competitive environment with much uncertainty. When faced with uncertainty, organizations often believe that they must convince society that their existence is legitimate. Increasing specialization and organizational complexity in healthcare professions have made the expert important. Experts, such as the role assumed by hospital accountants, maintain power because the organization depends on them for their special skills and information. Scarce resources coupled with uncertainty move hospital accountants as experts into the power equation in the changing control of the U.S. healthcare system. Since accountants often serve as monitors of scarce resources, information about the resource allocation directly affects the distribution of power. This places hospital accountants in a critical role of assisting their institutions in adapting to a new environment.

  1. Surface shape measurement by phase-shifting digital holography with a wavelength shift.

    PubMed

    Yamaguchi, Ichirou; Ida, Takashi; Yokota, Masayuki; Yamashita, Kouji

    2006-10-10

    Surface contouring by phase-shifting digital holography is proposed and verified by experiments and numerical simulations. Digital holograms are recorded before and after mode hopping of a laser diode subject to current tuning, and the difference of the reconstructed phases at each wavelength is computed to deliver surface contours of a diffusely reflecting surface. Since normal incidence on the object is employed, the method does not need the removal of the tilt component and is free from the shadowing effect as advantages over the dual-incidence method proposed before by the first author.

  2. Impacts of shift work on sleep and circadian rhythms.

    PubMed

    Boivin, D B; Boudreau, P

    2014-10-01

    Shift work comprises work schedules that extend beyond the typical "nine-to-five" workday, wherein schedules often comprise early work start, compressed work weeks with 12-hour shifts, and night work. According to recent American and European surveys, between 15 and 30% of adult workers are engaged in some type of shift work, with 19% of the European population reportedly working at least 2 hours between 22:00 and 05:00. The 2005 International Classification of Sleep Disorders estimates that a shift work sleep disorder can be found in 2-5% of workers. This disorder is characterized by excessive sleepiness and/or sleep disruption for at least one month in relation with the atypical work schedule. Individual tolerance to shift work remains a complex problem that is affected by the number of consecutive work hours and shifts, the rest periods, and the predictability of work schedules. Sleepiness usually occurs during night shifts and is maximal at the end of the night. Impaired vigilance and performance occur around times of increased sleepiness and can seriously compromise workers' health and safety. Indeed, workers suffering from a shift work sleep-wake disorder can fall asleep involuntarily at work or while driving back home after a night shift. Working on atypical shifts has important socioeconomic impacts as it leads to an increased risk of accidents, workers' impairment and danger to public safety, especially at night. The aim of the present review is to review the circadian and sleep-wake disturbances associated with shift work as well as their medical impacts.

  3. Shift Work and Occupational Stress in Police Officers

    PubMed Central

    Ma, Claudia C.; Andrew, Michael E.; Fekedulegn, Desta; Gu, Ja K.; Hartley, Tara A.; Charles, Luenda E.; Violanti, John M.; Burchfiel, Cecil M.

    2014-01-01

    Background Shift work has been associated with occupational stress in health providers and in those working in some industrial companies. The association is not well established in the law enforcement workforce. Our objective was to examine the association between shift work and police work-related stress. Methods The number of stressful events that occurred in the previous month and year was obtained using the Spielberger Police Stress Survey among 365 police officers aged 27–66 years. Work hours were derived from daily payroll records. A dominant shift (day, afternoon, or night) was defined for each participant as the shift with the largest percentage of total time a participant worked (starting time from 4:00 AM to 11:59 AM, from 12 PM to 7:59 PM, and from 8:00 PM to 3:59 AM for day, afternoon, and night shift, respectively) in the previous month or year. Analysis of variance and covariance were used to examine the number of total and subscale (administrative/professional pressure, physical/psychological danger, or organizational support) stressful events across the shift. Results During the previous month and year, officers working the afternoon and night shifts reported more stressful events than day shift officers for total stress, administrative/professional pressure, and physical/psychological danger (p < 0.05). These differences were independent of age, sex, race/ethnicity, and police rank. The frequency of these stressful events did not differ significantly between officers working the afternoon and night shifts. Conclusion Non–day shift workers may be exposed to more stressful events in this cohort. Interventions to reduce or manage police stress that are tailored by shift may be considered. PMID:25830066

  4. Insects overshoot the expected upslope shift caused by climate warming.

    PubMed

    Bässler, Claus; Hothorn, Torsten; Brandl, Roland; Müller, Jörg

    2013-01-01

    Along elevational gradients, climate warming may lead to an upslope shift of the lower and upper range margin of organisms. A recent meta-analysis concluded that these shifts are species specific and considerably differ among taxonomic lineages. We used the opportunity to compare upper range margins of five lineages (plants, beetles, flies, hymenoptera, and birds) between 1902-1904 and 2006-2007 within one region (Bavarian Forest, Central Europe). Based on the increase in the regional mean annual temperature during this period and the regional lapse rate, the upslope shift is expected to be between 51 and 201 m. Averaged across species within lineages, the range margin of all animal lineages shifted upslope, but that of plants did not. For animals, the observed shifts were probably due to shifts in temperature and not to changes in habitat conditions. The range margin of plants is therefore apparently not constrained by temperature, a result contrasting recent findings. The mean shift of birds (165 m) was within the predicted range and consistent with a recent global meta-analysis. However, the upslope shift of the three insect lineages (>260 m) exceeded the expected shift even after considering several sources of uncertainty, which indicated a non-linear response to temperature. Our analysis demonstrated broad differences among lineages in their response to climate change even within one region. Furthermore, on the considered scale, the response of ectothermic animals was not consistent with expectations based on shifts in the mean annual temperature. Irrespective of the reasons for the overshooting of the response of the insects, these shifts lead to reorganizations in the composition of assemblages with consequences for ecosystem processes.

  5. PROMOTIONS: PROper MOTION Software

    NASA Astrophysics Data System (ADS)

    Caleb Wherry, John; Sahai, R.

    2009-05-01

    We report on the development of a software tool (PROMOTIONS) to streamline the process of measuring proper motions of material in expanding nebulae. Our tool makes use of IDL's widget programming capabilities to design a unique GUI that is used to compare images of the objects from two epochs. The software allows us to first orient and register the images to a common frame of reference and pixel scale, using field stars in each of the images. We then cross-correlate specific morphological features in order to determine their proper motions, which consist of the proper motion of the nebula as a whole (PM-neb), and expansion motions of the features relative to the center. If the central star is not visible (quite common in bipolar nebulae with dense dusty waists), point-symmetric expansion is assumed and we use the average motion of high-quality symmetric pairs of features on opposite sides of the nebular center to compute PM-neb. This is then subtracted out to determine the individual movements of these and additional features relative to the nebular center. PROMOTIONS should find wide applicability in measuring proper motions in astrophysical objects such as the expanding outflows/jets commonly seen around young and dying stars. We present first results from using PROMOTIONS to successfully measure proper motions in several pre-planetary nebulae (transition objects between the red giant and planetary nebula phases), using images taken 7-10 years apart with the WFPC2 and ACS instruments on board HST. The authors are grateful to NASA's Undergradute Scholars Research Program (USRP) for supporting this research.

  6. Chemical shift-based water/fat separation in the presence of susceptibility-induced fat resonance shift

    PubMed Central

    Karampinos, Dimitrios C.; Yu, Huanzhou; Shimakawa, Ann; Link, Thomas M.; Majumdar, Sharmila

    2011-01-01

    Chemical shift-based water/fat separation methods have been emerging due to the growing clinical need for fat quantification in different body organs. Accurate quantification of proton-density fat fraction requires the assessment of many confounding factors, including the need of modeling the presence of multiple peaks in the fat spectrum. Most recent quantitative chemical shift-based water/fat separation approaches rely on a multi-peak fat spectrum with pre-calibrated peak locations and pre-calibrated or self-calibrated peak relative amplitudes. However, water/fat susceptibility differences can induce fat spectrum resonance shifts depending on the shape and orientation of the fatty inclusions. The effect is of particular interest in the skeletal muscle due to the anisotropic arrangement of extracellular lipids. In the present work, the effect of susceptibility-induced fat resonance shift on the fat fraction is characterized in a conventional complex-based chemical shift-based water/fat separation approach that does not model the susceptibility-induced fat resonance shift. A novel algorithm is then proposed in order to quantify the resonance shift in a complex-based chemical shift-based water/fat separation approach that considers the fat resonance shift in the signal model, aiming to extract information about the orientation/geometry of lipids. The technique is validated in a phantom and preliminary in vivo results are shown in the calf musculature of healthy and diabetic subjects. PMID:22247024

  7. Promoting healthy sleep.

    PubMed

    Price, Bob

    2016-03-09

    Nurses are accustomed to helping others with their sleep problems and dealing with issues such as pain that may delay or interrupt sleep. However, they may be less familiar with what constitutes a healthy night's sleep. This article examines what is known about the process and purpose of sleep, and examines the ways in which factors that promote wakefulness and sleep combine to help establish a normal circadian rhythm. Theories relating to the function of sleep are discussed and research is considered that suggests that sleep deficit may lead to metabolic risks, including heart disease, obesity, type 2 diabetes mellitus and several types of cancer.

  8. An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA.

    PubMed Central

    Chamorro, M; Parkin, N; Varmus, H E

    1992-01-01

    Synthesis of the pol gene products of most retroviruses requires ribosomes to shift frame once or twice in the -1 direction while translating gag-pol mRNA. The viral signals for frameshifting include a heptanucleotide sequence on which the shift occurs and higher-order RNA structure just downstream of the shift site. We have made site-directed mutations in two stems (S1 and S2) of a putative RNA pseudoknot that begins 7 nucleotides 3' of the previously identified shift site (A AAA AAC) in the gag-pro region of mouse mammary tumor virus (MMTV) RNA. The mutants confirm the predicted structure, show that loss of either S1 or S2 impairs frameshifting, and exclude alternative RNA structures as significant for frameshifting. The importance of the MMTV pseudoknot has been further demonstrated by showing that shift sites from two other retroviruses function more efficiently in the position of the MMTV site than in their native contexts. However, the MMTV pseudoknot cannot promote detectable frameshifting in the absence of a recognizable upstream shift site. In addition, the species of tRNA that reads the second codon in the shift site appears to be a critical determinant, since changing the 7th nucleotide in the MMTV gag-pro shift site from C to A, U, or G severely impairs frameshifting. Images PMID:1309954

  9. Egypt's FOF shifts into high gear.

    PubMed

    1983-01-01

    Family of the Future (FOF), a private Egyptian family planning organization, is implementing a number of new activities in its 4 year old contraceptive social marketing program. These changes, in part, are a response to the recommendations made in a 1982 audit of the program. New activities include television advertising of contraceptives, implementation of a physician training program, and expansion of the program's product line. In 1980, FOF initiated a televised promotional campaign for several of its products. Television advertising is generally not approved of in Arab countries. The FOF television ads generated some religious controversy but spurred lagging sales of the program's condoms and vaginal foam tablets (Annan). Prior to the campaign, sales of Annan averaged 35,000 tablets/month. During the 1st month following the television campaign, sales reached 660,000 and during the 2nd month, more than 1 million tablets were sold. An IUD insertion training program for physicians was implemented in October, 1983. Contraceptive training in Egyptian medical shools is inadequate. As a result physicians are hesitant about recommending IUDs to their patients. IUDs are popular among poor urban women, and IUDs acoount for more than 1/2 of the couple years of protection provided by the FOF program. Another training program is currently being developed for the purpose of improving the marketing skills of FOF managers. The program's product line is expected to increase. A low dose oral contraceptive will be introducted in late 1983 or early 1984, and plans are being developed for the introduction of an ultra-thin condom. The program is also considering selling several noncontraceptive items. Products udner consideration are surgical gloves as a supplemental item for the program's IUD kits, pregnancy test kits, and vitamin supplements for pregnant women.

  10. Cooperate! A paradigm shift for health equity.

    PubMed

    Chang, Wei-Ching; Fraser, Joy H

    2017-02-21

    The role of competition and cooperation in relation to the goal of health equity is examined in this paper. The authors explain why the win-lose mentality associated with avoidable competition is ethically questionable and less effective than cooperation in achieving positive outcomes, particularly as it relates to health and health equity. Competition, which differentiates winners from losers, often with the winner-takes-all reward system, inevitably leads to a few winners and many losers, resulting in social inequality, which, in turn, engenders and perpetuates health inequity.Competitive market-driven approaches to healthcare-brought about by capitalism, neo-liberalization, and globalization, based primarily on a competitive framework-are shown to have contributed to growing inequities with respect to the social determinants of health, and have undermined equal opportunity to access health care and achieve health equity. It is possible to redistribute income and wealth to reduce social inequality, but globalization poses increasing challenges to policy makers. John Stuart Mill provided a passionate, philosophical defense of cooperatives, followed by Karl Polanyi who offered an insightful critique of both state socialism and especially the self-regulating market, thereby opening up the cooperative way of shaping the future. We cite Hannah Arendt's "the banality of evil" to characterize the tragic concept of "ethical fading" witnessed in business and everyday life all over the world, often committed (without thinking and reflecting) by ordinary people under competitive pressures.To promote equity in health for all, we recommend the adoption of a radically new cooperation paradigm, applied whenever possible, to everything in our daily lives.

  11. Improving the resolution in phase-shifting Gabor holography by CCD shift

    NASA Astrophysics Data System (ADS)

    Granero, L.; Micó, V.; Zalevsky, Z.; García, J.; Javidi, B.

    2015-05-01

    Holography dates back to the year when Dennis Gabor reported on a method to avoid spherical aberration and to improve image quality in electron microscopy. Gabor's two-step holographic method was pioneer but suffered from three major drawbacks: the reconstructed image is affected by coherent noise, the twin image problem of holography that also affects the final image quality, and a restricted sample range (weak diffraction assumption) for preserving the holographic behavior of the method. Nowadays, most of those drawbacks have been overcome and new capabilities have been added due to the replacement of the classical recording media (photographic plate) by digital sensors (CCD and CMOS cameras). But in the Gabor' regime, holography is restricted to weak diffraction assumptions because otherwise, diffraction prevents an accurate recovery of the object's complex wavefront. In this contribution, we present an experimental approach to overcome such limitation and improve final image resolution. We use the phase-shifting Gabor configuration while the CCD camera is shifted to different off-axis positions in order to capture a bigger portion of the diffracted wavefront. Thus, once the whole image set is recorded and digitally processed for each camera's position, we merge the resulting band-pass images into one image by assembling a synthetic aperture. Finally, a superresolved image is recovered by Fourier transformation of the information contained in the generated synthetic aperture. Experimental results are provided using a USAF resolution test target and validating our concepts for a gain in resolution of close to 2.

  12. Global mental health: Global strengths and strategies Task-shifting in a shifting health economy.

    PubMed

    McInnis, Melvin G; Merajver, Sofia D

    2011-09-01

    Global mental health challenges sit at the frontiers of health care worldwide. The frequency of mental health disorders is increasing, and represents a large portion of the global burden of human disease (DALYs). There are many impeding forces in delivering mental health care globally. The knowledge of what mental health and its diseased states are limits the ability to seek appropriate care. Limited training and experience among primary providers dilutes the capacity of systems for adequate care, support, and intervention. There are limited numbers of medical personnel worldwide to attend to individuals afflicted by mental health disorders. The challenges of global mental health are the capacity of the global systems to enhance knowledge and literacy surrounding mental health disorders, enhance and expand ways of identifying and treating mental health disorders effectively at an early stage in its course. Much has been written about the epidemiology of mental health disorders globally followed by discussions of the need for improvements in programs that will improve the lot of the mentally ill. Task shifting involves the engaging of human resources, generally nonprofessional, in the care of mental health disorders. Engaging traditional healers and community health workers in the identification and management of mental health disorders is a very strong potential opportunity for task shifting care in mental health. In doing so it will be necessary to study the concept of mental health literacy of traditional healers and health workers in a process of mutual alignment of purpose founded on evidence based research.

  13. Relations among early postexposure noise-induced threshold shifts and permanent threshold shifts in the chinchilla

    NASA Astrophysics Data System (ADS)

    Hamernik, Roger P.; Ahroon, William A.; Patterson, James H.; Qiu, Wei

    2002-01-01

    Threshold shifts (TS) were measured at various times following a wide variety of noise exposures on over 900 chinchillas. An analysis of postexposure TS measures and noise-induced permanent threshold shift (PTS) showed that, across audiometric test frequency, there was a consistent relation between these variables of the form PTS (dB)=α(eTS/β-1), where, for a given test frequency, α (dB) and β (dB) are constants. TSs were measured immediately following exposure (TS0), 24 h after exposure (TS24), and at several intermediate times in order to estimate the maximum TS (TSmax). Correlation between TS and PTS at the various test frequencies was highest for TS24. An analysis of the 90th-percentile PTS showed a linear growth of PTS with TS24 of approximately 0.7 dB PTS/dB TS24. These data provide some support, in the chinchilla model, for a variation of the three postulates originally presented by Kryter et al. [J. Acoust. Soc. Am. 39, 451 (1966)]. Specifically: (i) TS24 is a consistent measure of the effects of a traumatic noise exposure. (ii) All exposures that produce a given TS24 will be equally hazardous. (iii) Noise-induced PTS in the most susceptible animals, following many years of exposure, is approximately equal to (0.7)TS24 measured after an 8-h exposure to the same noise.

  14. Changing the waveform of circadian rhythms: considerations for shift-work.

    PubMed

    Harrison, Elizabeth M; Gorman, Michael R

    2012-01-01

    Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythmic waveform (i.e., the shape of its 24 h oscillation), rather than phase, however, may better match performance demands of shift-workers and can be quickly and feasibly implemented in animals. In fact, a bifurcated pacemaker waveform may permit stable entrainment of a bimodal sleep/wake rhythm promoting alertness in both night and daylight hours. Although bifurcation has yet to be formally assessed in humans, evidence of conserved properties of circadian organization and plasticity predict its occurrence: humans respond to conventional manipulations of waveform (e.g., photoperiodism); behaviorally, the sleep/wake rhythm is adaptable; and finally, the human circadian system likely derives from the same multiple cellular oscillators that permit waveform flexibility in the rodent pacemaker. In short, investigation into untried manipulations of waveform in humans to facilitate adjustment to challenging schedules is justified.

  15. Sensitivity of coral recruitment to subtle shifts in early community succession.

    PubMed

    Doropoulos, Christopher; Roff, George; Visser, Mart-Simone; Mumby, Peter J

    2017-02-01

    Community succession following disturbance depends on positive and negative interactions, the strength of which change along environmental gradients. To investigate how early succession affects coral reef recovery, we conducted an 18-month experiment in Palau, using recruitment tiles and herbivore exclusion cages. One set of reefs has higher wave exposure and had previously undergone a phase shift to macroalgae following a major typhoon, whereas the other set of reefs have lower wave exposure and did not undergo a macroalgal phase shift. Similar successional trajectories were observed at all sites when herbivores were excluded: turf algae dominated early succession, followed by shifts to foliose macroalgae and heterotrophic invertebrates. However, trajectories differed in the presence of herbivores. At low wave exposure reefs, herbivores promoted coralline algae and limited turf and encrusting fleshy algae in crevice microhabitats, facilitating optimal coral recruitment. Under medium wave exposure, relatively higher but still low coverage of turf and encrusting fleshy algae (15-25%) found in crevice microhabitats inhibited coral recruitment, persisting throughout multiple recruitment events. Our results indicate that altered interaction strength in different wave environments following disturbance can drive subtle changes in early succession that cascade to alter secondary succession to coral recruitment and system recovery.

  16. Microbial and sponge loops modify fish production in phase-shifting coral reefs.

    PubMed

    Silveira, Cynthia B; Silva-Lima, Arthur W; Francini-Filho, Ronaldo B; Marques, Jomar S M; Almeida, Marcelo G; Thompson, Cristiane C; Rezende, Carlos E; Paranhos, Rodolfo; Moura, Rodrigo L; Salomon, Paulo S; Thompson, Fabiano L

    2015-10-01

    Shifts from coral to algae dominance of corals reefs have been correlated to fish biomass loss and increased microbial metabolism. Here we investigated reef benthic and planktonic primary production, benthic dissolved organic carbon (DOC) release and bacterial growth efficiency in the Abrolhos Bank, South Atlantic. Benthic DOC release rates are higher while water column bacterial growth efficiency is lower at impacted reefs. A trophic model based on the benthic and planktonic primary production was able to predict the observed relative fish biomass in healthy reefs. In contrast, in impacted reefs, the observed omnivorous fish biomass is higher, while that of the herbivorous/coralivorous fish is lower than predicted by the primary production-based model. Incorporating recycling of benthic-derived carbon in the model through microbial and sponge loops explains the difference and predicts the relative fish biomass in both reef types. Increased benthic carbon release rates and bacterial carbon metabolism, but decreased bacterial growth efficiency could lead to carbon losses through respiration and account for the uncoupling of benthic and fish production in phase-shifting reefs. Carbon recycling by microbial and sponge loops seems to promote an increase of small-bodied fish productivity in phase-shifting coral reefs.

  17. Shift in the Use of Migrant Community Languages in Australia

    ERIC Educational Resources Information Center

    Karidakis, Maria; Arunachalam, Dharma

    2016-01-01

    In this paper, we first explore the trends in the maintenance of migrant community languages among the first generation migrants and then the socio-economic variation in the shift in use of community languages. Our analysis showed that language shift to English among first generation migrants has not been uniform, with some migrant groups adopting…

  18. Phase-shift interferometry with a digital photocamera

    NASA Astrophysics Data System (ADS)

    Vannoni, Maurizio; Trivi, Marcelo; Molesini, Giuseppe

    2007-01-01

    A phase-shift interferometry experiment is proposed, working on a Twyman-Green optical configuration with additional polarization components. A guideline is provided to modern phase-shift interferometry, using concepts and laboratory equipment at the level of undergraduate optics courses.

  19. Polarization Phase-Shift Interferometry: A Simple Laboratory Setup

    NASA Astrophysics Data System (ADS)

    Vannoni, Maurizio; Trivi, Marcelo; Molesini, Giuseppe

    2008-04-01

    An interferometry experiment is proposed, working on a Twyman-Green optical configuration. The interferogram is acquired with a digital camera and processed. Using polarization components the interferogram is phase-shifted and four different interferograms are acquired. The experiment is proposed as an introduction to modern phase-shift interferometry, using concepts and laboratory equipment at the level of undergraduate optics courses.

  20. Firefighters’ Physical Activity across Multiple Shifts of Planned Burn Work

    PubMed Central

    Chappel, Stephanie E.; Aisbett, Brad; Vincent, Grace E.; Ridgers, Nicola D.

    2016-01-01

    Little is currently known about the physical activity patterns of workers in physically demanding populations. The aims of this study were to (a) quantify firefighters’ physical activity and sedentary time within (2-h periods) and across planned burn shifts; and (b) examine whether firefighters’ activity levels during one shift or 2-h period was associated with their activity levels in the following shift or 2-h period. Thirty-four salaried firefighters (26 men, 8 women) wore an Actical accelerometer for 28 consecutive days. Time spent sedentary (SED) and in light- (LPA), moderate- (MPA) and vigorous-intensity physical activity (VPA) were derived using validated cut-points. Multilevel analyses (shift, participant) were conducted using generalised linear latent and mixed models. Firefighters spent the majority of a planned burn shift (average length 10.4 h) or 2-h period engaged in LPA (69% and 70%, respectively). No significant associations were observed between SED and physical activity levels between consecutive planned burned shifts or 2-h periods. The physical activity that a firefighter engaged in during one shift (or 2-h period) did not subsequently affect their physical activity levels in the subsequent shift (or 2-h period). Further research is needed to establish how workers in physically demanding populations are able to sustain their activity levels over long periods of time. PMID:27706057

  1. Seismic Overstatement: Challenging the Paradigm Shift in Composition.

    ERIC Educational Resources Information Center

    Bell, James

    1995-01-01

    Discusses Maxine Hairston's appropriation in 1982 of Thomas Kuhn's epistemology and his concept of "paradigm shift." Argues that the paradigm shift must be treated as an enabling fiction through which members of the professional can speculate on better ways to teach students. (SR)

  2. Globalisation and Higher Education Funding Policy Shifts in Kenya

    ERIC Educational Resources Information Center

    Wangenge-Ouma, Gerald

    2008-01-01

    This paper identifies, examines and discusses higher education funding policy shifts that have taken place in Kenya. The paper argues that even though Kenya's higher education funding policy shifts, from free higher education to cost-sharing, and privatisation and commercialisation, are (to a greater extent) products of the country's encounter…

  3. Generalized harmonic spatial coordinates and hyperbolic shift conditions

    SciTech Connect

    Alcubierre, Miguel; Corichi, Alejandro; Nunez, Dario; Salgado, Marcelo; Gonzalez, Jose A.; Reimann, Bernd

    2005-12-15

    We propose a generalization of the condition for harmonic spatial coordinates analogous to the generalization of the harmonic time slices introduced by Bona et al., and closely related to dynamic shift conditions recently proposed by Lindblom and Scheel, and Bona and Palenzuela. These generalized harmonic spatial coordinates imply a condition for the shift vector that has the form of an evolution equation for the shift components. We find that in order to decouple the slicing condition from the evolution equation for the shift it is necessary to use a rescaled shift vector. The initial form of the generalized harmonic shift condition is not spatially covariant, but we propose a simple way to make it fully covariant so that it can be used in coordinate systems other than Cartesian. We also analyze the effect of the shift condition proposed here on the hyperbolicity of the evolution equations of general relativity in 1+1 dimensions and 3+1 spherical symmetry, and study the possible development of blowups. Finally, we perform a series of numerical experiments to illustrate the behavior of this shift condition.

  4. Physiological and Psychological Aspects of Night and Shift Work.

    ERIC Educational Resources Information Center

    Wojtczak-Jaroszowa, Jadwiga

    Results of physiological and psychological studies related to night and shift work are reviewed from the standpoint of their possible use by industry in understanding the problems of shift work and finding solutions. (New research data that has appeared since original preparation of the manuscript is presented in a three-part addendum with…

  5. Detection and Assessment of Ecosystem Regime Shifts from Fisher Information

    EPA Science Inventory

    Ecosystem regime shifts, which are long-term system reorganizations, have profound implications for sustainability. There is a great need for indicators of regime shifts, particularly methods that are applicable to data from real systems. We have developed a form of Fisher info...

  6. 33 CFR 329.13 - Geographic limits: Shifting boundaries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Geographic limits: Shifting boundaries. 329.13 Section 329.13 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DEFINITION OF NAVIGABLE WATERS OF THE UNITED STATES § 329.13 Geographic limits: Shifting boundaries. Permanent changes...

  7. Shifting Themes in OECD Country Reviews of Higher Education

    ERIC Educational Resources Information Center

    Hunter, Carrie P.

    2013-01-01

    There have been changes in the political economy since the 1980s, and the Organization for Economic Cooperation and Development (OECD) has changed as well. Scholars have noted shifts in OECD discourse in some policy fields since that time: shifts away from what might be called classic neoliberal perspectives. This paper reflects on the changes in…

  8. Empirical NMR Chemical Shift Correlations for Methyl and Methylene Protons.

    ERIC Educational Resources Information Center

    Friedrich, Edwin C.; Runkle, Katherine Gates

    1984-01-01

    Presents an internally consistent set of 63 substituent constants developed for use with the Schoolery Relationship to predict the chemical shifts of methylene protons of acyclic compounds. Chemical shift data used in deriving the constants were taken mainly from primary sources of HNMR (nuclear magnetic resonance) spectra. (JN)

  9. Vocal Pitch Shift in Congenital Amusia (Pitch Deafness)

    ERIC Educational Resources Information Center

    Hutchins, Sean; Peretz, Isabelle

    2013-01-01

    We tested whether congenital amusics, who exhibit pitch perception deficits, nevertheless adjust the pitch of their voice in response to a sudden pitch shift applied to vocal feedback. Nine amusics and matched controls imitated their own previously-recorded speech or singing, while the online feedback they received was shifted mid-utterance by 25…

  10. Effects of Verbal and Spatial Questions on Initial Gaze Shifts.

    ERIC Educational Resources Information Center

    Ehrlichman, Howard; And Others

    The direction of subjects' first gaze shift following questions designed to elicit verbal-linguistic or visuo-spatial processing was examined in three experiments under video camera and face-to-face interview conditions. In all three experiments, verbal questions elicited significantly more downward gaze shifts than spatial questions. However,…

  11. Negotiating Academic Teacher Identity Shifts during Higher Education Contextual Change

    ERIC Educational Resources Information Center

    McNaughton, Susan Maree; Billot, Jennie

    2016-01-01

    Higher education teachers' roles and identities are constantly shifting in response to contextual change. Pedagogy, values, and professional and personal narratives of self are all affected, particularly by technological change. This paper explores the role and identity shifts of academics during the introduction of large-class videoconferencing.…

  12. Attentional Set-Shifting in Fragile X Syndrome

    ERIC Educational Resources Information Center

    Van der Molen, M. J. W.; Van der Molen, M. W.; Ridderinkhof, K. R.; Hamel, B. C. J.; Curfs, L. M. G.; Ramakers, G. J. A.

    2012-01-01

    The ability to flexibly adapt to the changing demands of the environment is often reported as a core deficit in fragile X syndrome (FXS). However, the cognitive processes that determine this attentional set-shifting deficit remain elusive. The present study investigated attentional set-shifting ability in fragile X syndrome males with the…

  13. Relative Configuration of Natural Products Using NMR Chemical Shifts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    By comparing calculated with experimental NMR chemical shifts, we were able to determine the relative configurations of three monoterpene diastereomers produced by the walkingstick Anisomorpha buprestoides. The combined RMSDs of both 1H and 13C quantum chemically calculated shifts were able to predi...

  14. Firefighters' Physical Activity across Multiple Shifts of Planned Burn Work.

    PubMed

    Chappel, Stephanie E; Aisbett, Brad; Vincent, Grace E; Ridgers, Nicola D

    2016-09-30

    Little is currently known about the physical activity patterns of workers in physically demanding populations. The aims of this study were to (a) quantify firefighters' physical activity and sedentary time within (2-h periods) and across planned burn shifts; and (b) examine whether firefighters' activity levels during one shift or 2-h period was associated with their activity levels in the following shift or 2-h period. Thirty-four salaried firefighters (26 men, 8 women) wore an Actical accelerometer for 28 consecutive days. Time spent sedentary (SED) and in light- (LPA), moderate- (MPA) and vigorous-intensity physical activity (VPA) were derived using validated cut-points. Multilevel analyses (shift, participant) were conducted using generalised linear latent and mixed models. Firefighters spent the majority of a planned burn shift (average length 10.4 h) or 2-h period engaged in LPA (69% and 70%, respectively). No significant associations were observed between SED and physical activity levels between consecutive planned burned shifts or 2-h periods. The physical activity that a firefighter engaged in during one shift (or 2-h period) did not subsequently affect their physical activity levels in the subsequent shift (or 2-h period). Further research is needed to establish how workers in physically demanding populations are able to sustain their activity levels over long periods of time.

  15. On Explaining Language Shift: Sociology or Social Psychology of Language?

    ERIC Educational Resources Information Center

    Maitz, Peter

    2011-01-01

    This study investigates the potentials and limits of sociolinguistic research on language shift. Starting from a position that the ultimate goal of the research must be to create a general theory of language shift of predictive power, the author examines the explanatory potential of current mainstream research methodology now regarded as canonical…

  16. Changes of physiological functions induced by shift work.

    PubMed

    Herichova, I

    2013-07-01

    Shift work was positively associated with higher incidence of metabolic syndrome, obesity, cardiovascular disease, sleep disturbances, decreased immune functions, and cancer. Observed disorders were manifested usually after longer time of shift work (more than 10 years). On the other hand, disturbed daily profile of melatonin and cortisol during shift work were detected even in human self reporting well tolerated shift work. Similarly, changes in thyroid stimulating hormone, prolactin, growth hormone, insulin, and ghrelin were demonstrated. Changes in hormone concentrations are influenced by shift work, sleep or circadian system or combinations of above mentioned regulatory factors. The circadian system consists of the central part localized in the hypothalamus and peripheral oscillators located in all tissues of the body. The central oscillator is predominantly synchronized by light and peripheral oscillators are more responsive to metabolic signals. Under conditions of shift work, central and peripheral oscillators dissociate that causes misalignment of daily rhythms in physiological functions. Synchronization during shift work can be improved by melatonin supplementation and manipulation with light:dark cycles and food regimens. Shift work tolerance is individual. Partial positive selection can be achieved on the basis of several psychological traits. Appropriate schedule can be estimated on the basis of chronotype.

  17. Researching Style: Epistemology, Paradigm Shifts and Research Interest Groups

    ERIC Educational Resources Information Center

    Rayner, Stephen

    2011-01-01

    This paper identifies the need for a deliberate approach to theory building in the context of researching cognitive and learning style differences in human performance. A case for paradigm shift and a focus upon research epistemology is presented, building upon a recent critique of style research. A proposal for creating paradigm shift is made,…

  18. Tune shifts due to systematic errors in bend magnets

    SciTech Connect

    Douglas, D.

    1983-12-01

    The presence of systematic error multipoles in bend magnets, persistent currents at low magnet excitation, and saturation effects at high magnet excitation may all lead to tune shifts which could prove detrimental to the operation of the SSC. It is the purpose of this note to report estimates of the magnitude of these tune shifts and the corrector strengths required to circumvent them.

  19. Rotating night shift work and the risk of ischemic stroke.

    PubMed

    Brown, Devin L; Feskanich, Diane; Sánchez, Brisa N; Rexrode, Kathryn M; Schernhammer, Eva S; Lisabeth, Lynda D

    2009-06-01

    Rotating night shift work disrupts circadian rhythms and is associated with coronary heart disease. The relation between rotating night shift work and ischemic stroke is unclear. The Nurses' Health Study, an ongoing cohort study of registered female nurses, assessed in 1988 the total number of years the nurses had worked rotating night shifts. The majority (69%) of stroke outcomes from 1988 to 2004 were confirmed by physician chart review. The authors used Cox proportional hazards models to assess the relation between years of rotating night shift work and ischemic stroke, adjusting for multiple vascular risk factors. Of 80,108 subjects available for analysis, 60% reported at least 1 year of rotating night shift work. There were 1,660 ischemic strokes. Rotating night shift work was associated with a 4% increased risk of ischemic stroke for every 5 years (hazard ratio = 1.04, 95% confidence interval: 1.01, 1.07; P(trend) = 0.01). This increase in risk was similar when limited to the 1,152 confirmed ischemic strokes (hazard ratio = 1.03, 95% confidence interval: 0.99, 1.07; P(trend) = 0.10) and may be confined to women with a history of 15 or more years of rotating shift work. Women appear to have a modestly increased risk of stroke after extended periods of rotating night shift work.

  20. Ecological correlates of range shifts of Late Pleistocene mammals.

    PubMed

    Lyons, S Kathleen; Wagner, Peter J; Dzikiewicz, Katherine

    2010-11-27

    Understanding and predicting how species' distributions will shift as climate changes are central questions in ecology today. The late Quaternary of North America represents a natural experiment in which we can evaluate how species responded during the expansion and contraction of the glaciers. Here, we ask whether species' range shifts differ because of taxonomic affinity, life-history traits, body size or topographic heterogeneity and whether the species survived the megafaunal extinction. There was no difference in range shifts between victims and survivors of the megafaunal extinction. In general, the change in the size of a species' range is not well correlated with any of the ecological or life-history traits evaluated. However, there are significant relationships between some variables and the movements of the centroids of ranges. Differences in the distances shifted exist among orders, although this is probably a result of body size differences as larger bodied species show larger shifts. Although there are a few exceptions, the distance that species shifted their range was weakly correlated with life-history traits. Finally, species in more topographically heterogeneous areas show smaller shifts than species in less-diverse areas. Overall, these results indicate that when trying to predict species range shifts in the future, body size, lifespan and the topographic relief of the landscape should be taken into account.