76 FR 13648 - Proposed Collection; Comment Request; Process Evaluation of the NIH Roadmap Epigenomics Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... assess program process and progress, is non-experimental. The assessment is based on secondary source... programs of the Agency. To reduce response bias and to make the survey as accessible as possible to busy principal investigators, the survey will be Web-based. Frequency of Response: Once. Affected Public...

75 FR 42081 - Proposed Information Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

.... This study uses an experimental design to assess the outcomes associated with participation in national... reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the... participation in youth corps may lead to measurable outcomes for participants. The study uses an experimental...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM... may issue a research, development, and demonstration permit for any hazardous waste treatment facility which proposes to utilize an innovative and experimental hazardous waste treatment technology or process...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM... may issue a research, development, and demonstration permit for any hazardous waste treatment facility which proposes to utilize an innovative and experimental hazardous waste treatment technology or process...

Dense cold baryonic matter

NASA Astrophysics Data System (ADS)

Stavinskiy, A. V.

2017-09-01

A possibility of studying cold nuclear matter on the Nuclotron-NICA facility at baryonic densities characteristic of and higher than at the center of a neutron star is considered based on the data from cumulative processes. A special rare-event kinematic trigger for collisions of relativistic ions is proposed for effective selection of events accompanied by production of dense baryonic systems. Possible manifestations of new matter states under these unusual conditions and an experimental program for their study are discussed. Various experimental setups are proposed for these studies, and a possibility of using experimental setups at the Nuclotron-NICA facility for this purpose is considered.

77 FR 26764 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... two sites, with the random assignment of AFI-eligible cases to program and control groups. The... Families (ACF) is proposing a data collection activity as part of an experimental evaluation of the Assets... outcomes? While some evaluations suggest that IDAs help low-income families save, rigorous experimental...

Send Your Students to Mars for Their next Research Project

ERIC Educational Resources Information Center

Lindgren, Charles

2006-01-01

The NASA's Mars Student Imaging Project (MSIP) is led by the Arizona State University (ASU) Mars Education Program, a major partner of NASA's Mars Exploration Program. MSIP is based on the National Science Education Standards and includes curriculum on terrestrial planet characteristics, experimental design, and proposal writing. Three spacecraft…

Real Time Updating Genetic Network Programming for Adapting to the Change of Stock Prices

NASA Astrophysics Data System (ADS)

Chen, Yan; Mabu, Shingo; Shimada, Kaoru; Hirasawa, Kotaro

The key in stock trading model is to take the right actions for trading at the right time, primarily based on the accurate forecast of future stock trends. Since an effective trading with given information of stock prices needs an intelligent strategy for the decision making, we applied Genetic Network Programming (GNP) to creating a stock trading model. In this paper, we propose a new method called Real Time Updating Genetic Network Programming (RTU-GNP) for adapting to the change of stock prices. There are three important points in this paper: First, the RTU-GNP method makes a stock trading decision considering both the recommendable information of technical indices and the candlestick charts according to the real time stock prices. Second, we combine RTU-GNP with a Sarsa learning algorithm to create the programs efficiently. Also, sub-nodes are introduced in each judgment and processing node to determine appropriate actions (buying/selling) and to select appropriate stock price information depending on the situation. Third, a Real Time Updating system has been firstly introduced in our paper considering the change of the trend of stock prices. The experimental results on the Japanese stock market show that the trading model with the proposed RTU-GNP method outperforms other models without real time updating. We also compared the experimental results using the proposed method with Buy&Hold method to confirm its effectiveness, and it is clarified that the proposed trading model can obtain much higher profits than Buy&Hold method.

Telecommuting for Original Cataloging at the Michigan State University Libraries.

ERIC Educational Resources Information Center

Black, Leah; Hyslop, Colleen

1995-01-01

Working conditions in library technical services departments can be a problem for catalogers in need of a quiet work environment. Based on a successful program for indexers at the National Agriculture Library, a proposal for an experimental telecommuting program for original cataloging at the Michigan State University Libraries was developed and…

Technological Resources to Prevent Cyberbullying During Adolescence: The Cyberprogram 2.0 Program and the Cooperative Cybereduca 2.0 Videogame

PubMed Central

Garaigordobil, Maite; Martínez-Valderrey, Vanesa

2018-01-01

Bullying and cyberbullying have serious consequences for all those involved, especially the victims, and its prevalence is high throughout all the years of schooling, which emphasizes the importance of prevention. This article describes an intervention proposal, made up of a program (Cyberprogram 2.0 Garaigordobil and Martínez-Valderrey, 2014a) and a videogame (Cooperative Cybereduca 2.0 Garaigordobil and Martínez-Valderrey, 2016b) which aims to prevent and reduce cyberbullying during adolescence and which has been validated experimentally. The proposal has four objectives: (1) To know what bullying and cyberbullying are, to reflect on the people involved in these situations; (2) to become aware of the harm caused by such behaviors and the severe consequences for all involved; (3) to learn guidelines to prevent and deal with these situations: know what to do when one suffers this kind of violence or when observing that someone else is suffering it; and (4) to foster the development of social and emotional factors that inhibit violent behavior (e.g., communication, ethical-moral values, empathy, cooperation…). The proposal is structured around 25 activities to fulfill these goals and it ends with the videogame. The activities are carried out in the classroom, and the online video is the last activity, which represents the end of the intervention program. The videogame (www.cybereduca.com) is a trivial pursuit game with questions and answers related to bullying/cyberbullying. This cybernetic trivial pursuit is organized around a fantasy story, a comic that guides the game. The videogame contains 120 questions about 5 topics: cyberphenomena, computer technology and safety, cybersexuality, consequences of bullying/cyberbullying, and coping with bullying/cyberbullying. To evaluate the effectiveness of the intervention, a quasi-experimental design, with repeated pretest-posttest measures and control groups, was used. During the pretest and posttest stages, 8 assessment instruments were administered. The experimental group randomly received the intervention proposal, which consisted of one weekly 1-h session during the entire school year. The results obtained with the analyses of variance of the data collected before and after the intervention in the experimental and control groups showed that the proposal significantly promoted the following aspects in the experimental group: (1) a decrease in face-to-face bullying and cyberbullying behaviors, in different types of school violence, premeditated and impulsive aggressiveness, and in the use of aggressive conflict-resolution strategies; and (2) an increase of positive social behaviors, self-esteem, cooperative conflict-resolution strategies, and the capacity for empathy. The results provide empirical evidence for the proposal. The importance of implementing programs to prevent bullying in all its forms, from the beginning of schooling and throughout formal education, is discussed. PMID:29867695

Technological Resources to Prevent Cyberbullying During Adolescence: The Cyberprogram 2.0 Program and the Cooperative Cybereduca 2.0 Videogame.

PubMed

Garaigordobil, Maite; Martínez-Valderrey, Vanesa

2018-01-01

Bullying and cyberbullying have serious consequences for all those involved, especially the victims, and its prevalence is high throughout all the years of schooling, which emphasizes the importance of prevention. This article describes an intervention proposal, made up of a program (Cyberprogram 2.0 Garaigordobil and Martínez-Valderrey, 2014a) and a videogame (Cooperative Cybereduca 2.0 Garaigordobil and Martínez-Valderrey, 2016b) which aims to prevent and reduce cyberbullying during adolescence and which has been validated experimentally. The proposal has four objectives: (1) To know what bullying and cyberbullying are, to reflect on the people involved in these situations; (2) to become aware of the harm caused by such behaviors and the severe consequences for all involved; (3) to learn guidelines to prevent and deal with these situations: know what to do when one suffers this kind of violence or when observing that someone else is suffering it; and (4) to foster the development of social and emotional factors that inhibit violent behavior (e.g., communication, ethical-moral values, empathy, cooperation…). The proposal is structured around 25 activities to fulfill these goals and it ends with the videogame. The activities are carried out in the classroom, and the online video is the last activity, which represents the end of the intervention program. The videogame (www.cybereduca.com) is a trivial pursuit game with questions and answers related to bullying/cyberbullying. This cybernetic trivial pursuit is organized around a fantasy story, a comic that guides the game. The videogame contains 120 questions about 5 topics: cyberphenomena, computer technology and safety, cybersexuality, consequences of bullying/cyberbullying, and coping with bullying/cyberbullying. To evaluate the effectiveness of the intervention, a quasi-experimental design, with repeated pretest-posttest measures and control groups, was used. During the pretest and posttest stages, 8 assessment instruments were administered. The experimental group randomly received the intervention proposal, which consisted of one weekly 1-h session during the entire school year. The results obtained with the analyses of variance of the data collected before and after the intervention in the experimental and control groups showed that the proposal significantly promoted the following aspects in the experimental group: (1) a decrease in face-to-face bullying and cyberbullying behaviors, in different types of school violence, premeditated and impulsive aggressiveness, and in the use of aggressive conflict-resolution strategies; and (2) an increase of positive social behaviors, self-esteem, cooperative conflict-resolution strategies, and the capacity for empathy. The results provide empirical evidence for the proposal. The importance of implementing programs to prevent bullying in all its forms, from the beginning of schooling and throughout formal education, is discussed.

Adaptive Broadcasting Mechanism for Bandwidth Allocation in Mobile Services

PubMed Central

Horng, Gwo-Jiun; Wang, Chi-Hsuan; Chou, Chih-Lun

2014-01-01

This paper proposes a tree-based adaptive broadcasting (TAB) algorithm for data dissemination to improve data access efficiency. The proposed TAB algorithm first constructs a broadcast tree to determine the broadcast frequency of each data and splits the broadcast tree into some broadcast wood to generate the broadcast program. In addition, this paper develops an analytical model to derive the mean access latency of the generated broadcast program. In light of the derived results, both the index channel's bandwidth and the data channel's bandwidth can be optimally allocated to maximize bandwidth utilization. This paper presents experiments to help evaluate the effectiveness of the proposed strategy. From the experimental results, it can be seen that the proposed mechanism is feasible in practice. PMID:25057509

Advanced Communications Technology Satellite (ACTS). Phase 1: Industrial/academic experimenters

NASA Technical Reports Server (NTRS)

Maisel, James E.; Nowlin, Robert W.

1992-01-01

This report presents the work done at Arizona State University under the ACTS Experimenters Program. The main thrust of the Program was to develop experiments to test, evaluate, and prove the commercial worthiness of the ACTS satellite which is scheduled for launch in 1993. To accomplish this goal, meetings were held with various governmental, industrial, and academic units to discuss the ACTS satellite and its technology and possible experiments that would generate industrial interest and support for ASU's efforts. Several local industries generated several experiments of their own. The investigators submitted several experiments of educational, medical, commercial, and technical value and interest. The disposition of these experimental proposals is discussed in this report.

A Proposal for a Preventive Program for Risks Associated with the Use of the Internet and Its Impact upon Students' Awareness of Perverse Issues

ERIC Educational Resources Information Center

Al Saif, Abdulkarim A.

2010-01-01

The current study attempts to develop a preventive program to fend off the risks of using the internet by trying to test the effectiveness of raising students' awareness on various new technology-related issues. In order to achieve this goal, descriptive, analytical, and experimental approaches have been utilized. The program has been applied to a…

Public Service Communication Satellite Program

NASA Technical Reports Server (NTRS)

Brown, J. P.

1977-01-01

The proposed NASA Public Service Communication Satellite Program consists of four different activities designed to fulfill the needs of public service sector. These are: interaction with the users, experimentation with existing satellites, development of a limited capability satellite for the earliest possible launch, and initiation of an R&D program to develop the greatly increased capability that future systems will require. This paper will discuss NASA efforts in each of these areas.

Multi-gene genetic programming based predictive models for municipal solid waste gasification in a fluidized bed gasifier.

PubMed

Pandey, Daya Shankar; Pan, Indranil; Das, Saptarshi; Leahy, James J; Kwapinski, Witold

2015-03-01

A multi-gene genetic programming technique is proposed as a new method to predict syngas yield production and the lower heating value for municipal solid waste gasification in a fluidized bed gasifier. The study shows that the predicted outputs of the municipal solid waste gasification process are in good agreement with the experimental dataset and also generalise well to validation (untrained) data. Published experimental datasets are used for model training and validation purposes. The results show the effectiveness of the genetic programming technique for solving complex nonlinear regression problems. The multi-gene genetic programming are also compared with a single-gene genetic programming model to show the relative merits and demerits of the technique. This study demonstrates that the genetic programming based data-driven modelling strategy can be a good candidate for developing models for other types of fuels as well. Copyright © 2014 Elsevier Ltd. All rights reserved.

Linear programming phase unwrapping for dual-wavelength digital holography.

PubMed

Wang, Zhaomin; Jiao, Jiannan; Qu, Weijuan; Yang, Fang; Li, Hongru; Tian, Ailing; Asundi, Anand

2017-01-20

A linear programming phase unwrapping method in dual-wavelength digital holography is proposed and verified experimentally. The proposed method uses the square of height difference as a convergence standard and theoretically gives the boundary condition in a searching process. A simulation was performed by unwrapping step structures at different levels of Gaussian noise. As a result, our method is capable of recovering the discontinuities accurately. It is robust and straightforward. In the experiment, a microelectromechanical systems sample and a cylindrical lens were measured separately. The testing results were in good agreement with true values. Moreover, the proposed method is applicable not only in digital holography but also in other dual-wavelength interferometric techniques.

The Research and Training Activities for the Joint Institute for Aeronautics and Acoustics

NASA Technical Reports Server (NTRS)

Cantwell, Brian

1995-01-01

This proposal requests continued support for the program of activities to be undertaken by the Ames-Stanford Joint Institute for Aeronautics and Acoustics during the period 1 Oct. 1995 - 30 Sept. 1996. The emphasis in this program is on training and research in experimental and computational methods with application to aerodynamics, acoustics and the important interactions between them. The program comprises activities in active flow control, Large Eddy Simulation of jet noise, flap aerodynamics and acoustics and high lift modeling studies. During the proposed period there will be a continued emphasis on the interaction between NASA Ames, Stanford University and Industry, particularly in connection with the high lift activities.

The RAI DBS experiment with Olympus

NASA Astrophysics Data System (ADS)

Castelli, Enzo

The Italian broadcasting network (RAI) has studied the development of a national DBS service in an effort to outline a proposal for a space segment configuration compatible with development of new services, including HDTV. Proposals so far considered feature the integration of RAI's channel on Olympus in a future operational system and after extensive experimental use. Contents of the experimental program are discussed, and need for a broadcasting standard which considers projected introduction of HDTV is noted. The debate between RAI and consumer electronic industries on the use of broadcasting standards is outlined. The position of RAI in the context of HDTV and DBS is defined and the issue of determining the most effective transmission standard during the experimental stage is raised. It is pointed out that, in the absence of new production facilities for HDTV, the maximum quality which MAC will yield will be that of PAL since programs must be produced in PAL and then converted into MAC. Two alternatives for strategy on the use of broadcasting standards for DBS are offered. Finally, technical experiments and a market survey are discussed.

The Student Spaceflight Experiments Program: Access to the ISS for K-14 Students

NASA Astrophysics Data System (ADS)

Livengood, Timothy A.; Goldstein, J. J.; Vanhala, H. A. T.; Johnson, M.; Hulslander, M.

2012-10-01

The Student Spaceflight Experiments Program (SSEP) has flown 42 experiments to space, on behalf of students from middle school through community college, on 3 missions: each of the last 2 Space Shuttle flights, and the first SpaceX resupply flight to the International Space Station (ISS). SSEP plans 2 missions to the ISS per year for the foreseeable future, and is expanding the program to include 4-year undergraduate college students and home-schooled students. SSEP experiments have explored biological, chemical, and physical phenomena within self-contained enclosures developed by NanoRacks, currently in the form of MixStix Fluid Mixing Enclosures. Over 9000 students participated in the initial 3 missions of SSEP, directly experiencing the entire lifecycle of space science experimentation through community-wide participation in SSEP, taking research from a nascent idea through developing competitive research proposals, down-selecting to three proposals from each participating community and further selection of a single proposal for flight, actual space flight, sample recovery, analysis, and reporting. The National Air and Space Museum has hosted 2 National Conferences for SSEP student teams to report results in keeping with the model of professional research. Student teams have unflinchingly reported on success, failure, and groundbased efforts to develop proposals for future flight opportunities. Community participation extends outside the sciences and the immediate proposal efforts to include design competitions for mission patches (that also fly to space). Student experimenters have rallied around successful proposal teams to support a successful experiment on behalf of the entire community. SSEP is a project of the National Center for Earth and Space Science Education enabled through NanoRacks LLC, working in partnership with NASA under a Space Act Agreement as part of the utilization of the International Space Station as a National Laboratory.

Doctoral training in behavior analysis: Training generalized problem-solving skills

PubMed Central

Chase, Philip N.; Wylie, Ruth G.

1985-01-01

This essay provides guidelines for designing a doctoral program in behavior analysis. First, we propose a general accomplishment for all behavior analytic doctoral students: that they be able to solve problems concerning individual behavior within a range of environments. Second, in order to achieve this goal, we propose that students be trained in conceptual and experimental analysis of behavior, the application of behavioral principles and the administration of behavioral programs. This training should include class work, but it should emphasize the immersion of students in a variety of environments in which they are required to use behavior analytic strategies. Third, we provide an example of a hypothetical graduate program that involves the proposed training. Finally, an evaluation plan is suggested for determining whether a training program is in fact producing students who are generalized problem-solvers. At each step, we justify our point of view from a perspective that combines principles from behavior analysis and educational systems design. PMID:22478633

Country News.

ERIC Educational Resources Information Center

Population Education Newsletter and Forum, 1988

1988-01-01

Summarizes information shared at an international seminar on teacher training, the management of population education, and adolescent education. Proposes an evaluative research activity to assess the achievements of these experiences. Indicates that experimental schools have reported positive outcomes for the program. Describes efforts in several…

A Module Experimental Process System Development Unit (MEPSDU)

NASA Technical Reports Server (NTRS)

1981-01-01

The purpose of this program is to demonstrate the technical readiness of a cost effective process sequence that has the potential for the production of flat plate photovoltaic modules which met the price goal in 1986 of $.70 or less per watt peak. Program efforts included: preliminary design review, preliminary cell fabrication using the proposed process sequence, verification of sandblasting back cleanup, study of resist parameters, evaluation of pull strength of the proposed metallization, measurement of contact resistance of Electroless Ni contacts, optimization of process parameter, design of the MEPSDU module, identification and testing of insulator tapes, development of a lamination process sequence, identification, discussions, demonstrations and visits with candidate equipment vendors, evaluation of proposals for tabbing and stringing machine.

Different structures of monoclinic martensitic phases in titanium nickelide

NASA Astrophysics Data System (ADS)

Voronin, V. I.; Naish, V. E.; Novoselova, T. V.; Pushin, V. G.; Sagaradze, I. V.

2000-03-01

The detailed theoretical and experimental analysis has been undertaken to bring to light the true structure of the monoclinic phase in titanium nickelide (NiTi). Theoretical models for such a phase have been proposed to describe the experimental data. In addition to the well-known B19‧ phase two more structures - new monoclinic M phase with Cm space group and triclinic phase with P1 space group - have been produced and analyzed in detail. Diffraction patterns have been obtained from different NiTi samples by using the neutron diffractometer IVV2 at different temperatures. From the refinement by DBWS-9411 program all these neutron patterns have been decoded successfully. The proposed new structures and stereotype B19‧ one agree with correspondent experimental data and the agreement is quite good.

Automatic topics segmentation for TV news video

NASA Astrophysics Data System (ADS)

Hmayda, Mounira; Ejbali, Ridha; Zaied, Mourad

2017-03-01

Automatic identification of television programs in the TV stream is an important task for operating archives. This article proposes a new spatio-temporal approach to identify the programs in TV stream into two main steps: First, a reference catalogue for video features visual jingles built. We operate the features that characterize the instances of the same program type to identify the different types of programs in the flow of television. The role of video features is to represent the visual invariants for each visual jingle using appropriate automatic descriptors for each television program. On the other hand, programs in television streams are identified by examining the similarity of the video signal for visual grammars in the catalogue. The main idea of the identification process is to compare the visual similarity of the video signal features in the flow of television to the catalogue. After presenting the proposed approach, the paper overviews encouraging experimental results on several streams extracted from different channels and compounds of several programs.

Guidance for Evaluating the Safety of Experimental Releases of Mosquitoes, Emphasizing Mark-Release-Recapture Techniques

PubMed Central

Charlwood, J. Derek; Harrington, Laura C.; Lounibos, L. Philip; Reisen, William K.; Tabachnick, Walter J.

2018-01-01

Abstract Experimental releases of mosquitoes are performed to understand characteristics of populations related to the biology, ability to transmit pathogens, and ultimately their control. In this article, we discuss considerations related to the safety of experimental releases of living mosquitoes, applying principles of good practice in vector biology that protect human health and comfort. We describe specific factors of experimental releases of mosquitoes that we believe are critical to inform institutional biosafety committees and similar review boards to which proposals to conduct mosquito release experiments have been submitted. In this study, “experimental releases” means those that do not significantly increase vector capacity or nuisance biting relative to the unperturbed natural baseline. This document specifically does not address releases of mosquitoes for ongoing control programs or trials of new control methods for which broader assessments of risk are required. It also does not address releases of transgenic or exotic (non-native) mosquito species, both of which require particular regulatory approval. Experimental releases may include females and males and evaluation must consider their effects based on the number released, their genotype and phenotype, the environment into which they are released, and postrelease collection activities. We consider whether increases of disease transmission and nuisance biting might result from proposed experimental releases against the backdrop of natural population size variation. We recommend that experimental releases be conducted in a manner that can be reasonably argued to have insignificant negative effects. Reviewers of proposals for experimental releases should expect applicants to provide such an argument based on evidence from similar studies and their planned activities. This document provides guidance for creating and evaluating such proposals. PMID:29337660

Guidance for Evaluating the Safety of Experimental Releases of Mosquitoes, Emphasizing Mark-Release-Recapture Techniques.

PubMed

Benedict, Mark Q; Charlwood, J Derek; Harrington, Laura C; Lounibos, L Philip; Reisen, William K; Tabachnick, Walter J

2018-01-01

Experimental releases of mosquitoes are performed to understand characteristics of populations related to the biology, ability to transmit pathogens, and ultimately their control. In this article, we discuss considerations related to the safety of experimental releases of living mosquitoes, applying principles of good practice in vector biology that protect human health and comfort. We describe specific factors of experimental releases of mosquitoes that we believe are critical to inform institutional biosafety committees and similar review boards to which proposals to conduct mosquito release experiments have been submitted. In this study, "experimental releases" means those that do not significantly increase vector capacity or nuisance biting relative to the unperturbed natural baseline. This document specifically does not address releases of mosquitoes for ongoing control programs or trials of new control methods for which broader assessments of risk are required. It also does not address releases of transgenic or exotic (non-native) mosquito species, both of which require particular regulatory approval. Experimental releases may include females and males and evaluation must consider their effects based on the number released, their genotype and phenotype, the environment into which they are released, and postrelease collection activities. We consider whether increases of disease transmission and nuisance biting might result from proposed experimental releases against the backdrop of natural population size variation. We recommend that experimental releases be conducted in a manner that can be reasonably argued to have insignificant negative effects. Reviewers of proposals for experimental releases should expect applicants to provide such an argument based on evidence from similar studies and their planned activities. This document provides guidance for creating and evaluating such proposals.

The Cost-Accounting Mechanism in Higher Educational Institutions.

ERIC Educational Resources Information Center

Lukoshkin, A. P.; Min'ko, E. V.

1990-01-01

Examines the need to increase expenditures per student at Soviet technical institutes. Proposes seeking financial assistance from enterprises employing technical specialists. Outlines an experimental program in cost accounting. Suggests stipend and wage allotments and explains some of the contractual obligations involved. (CH)

75 FR 4053 - Notice of Proposed Information Collection Requests

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... important student outcomes. The study will use quasi-experimental designs to explore the relationship... student records data, principal surveys, and project director interviews. The U.S. Department of Education... Magnet Schools Assistance Program (MSAP) supported magnet schools are associated with improved student...

PSQP: Puzzle Solving by Quadratic Programming.

PubMed

Andalo, Fernanda A; Taubin, Gabriel; Goldenstein, Siome

2017-02-01

In this article we present the first effective method based on global optimization for the reconstruction of image puzzles comprising rectangle pieces-Puzzle Solving by Quadratic Programming (PSQP). The proposed novel mathematical formulation reduces the problem to the maximization of a constrained quadratic function, which is solved via a gradient ascent approach. The proposed method is deterministic and can deal with arbitrary identical rectangular pieces. We provide experimental results showing its effectiveness when compared to state-of-the-art approaches. Although the method was developed to solve image puzzles, we also show how to apply it to the reconstruction of simulated strip-shredded documents, broadening its applicability.

Designing for aircraft structural crashworthiness

NASA Technical Reports Server (NTRS)

Thomson, R. G.; Caiafa, C.

1981-01-01

This report describes structural aviation crash dynamics research activities being conducted on general aviation aircraft and transport aircraft. The report includes experimental and analytical correlations of load-limiting subfloor and seat configurations tested dynamically in vertical drop tests and in a horizontal sled deceleration facility. Computer predictions using a finite-element nonlinear computer program, DYCAST, of the acceleration time-histories of these innovative seat and subfloor structures are presented. Proposed application of these computer techniques, and the nonlinear lumped mass computer program KRASH, to transport aircraft crash dynamics is discussed. A proposed FAA full-scale crash test of a fully instrumented radio controlled transport airplane is also described.

A research program in empirical computer science

NASA Technical Reports Server (NTRS)

Knight, J. C.

1991-01-01

During the grant reporting period our primary activities have been to begin preparation for the establishment of a research program in experimental computer science. The focus of research in this program will be safety-critical systems. Many questions that arise in the effort to improve software dependability can only be addressed empirically. For example, there is no way to predict the performance of the various proposed approaches to building fault-tolerant software. Performance models, though valuable, are parameterized and cannot be used to make quantitative predictions without experimental determination of underlying distributions. In the past, experimentation has been able to shed some light on the practical benefits and limitations of software fault tolerance. It is common, also, for experimentation to reveal new questions or new aspects of problems that were previously unknown. A good example is the Consistent Comparison Problem that was revealed by experimentation and subsequently studied in depth. The result was a clear understanding of a previously unknown problem with software fault tolerance. The purpose of a research program in empirical computer science is to perform controlled experiments in the area of real-time, embedded control systems. The goal of the various experiments will be to determine better approaches to the construction of the software for computing systems that have to be relied upon. As such it will validate research concepts from other sources, provide new research results, and facilitate the transition of research results from concepts to practical procedures that can be applied with low risk to NASA flight projects. The target of experimentation will be the production software development activities undertaken by any organization prepared to contribute to the research program. Experimental goals, procedures, data analysis and result reporting will be performed for the most part by the University of Virginia.

[Study protocol of a prevention of recurrent suicidal behaviour program based on case management (PSyMAC)].

PubMed

Sáiz, Pilar A; Rodríguez-Revuelta, Julia; González-Blanco, Leticia; Burón, Patricia; Al-Halabí, Susana; Garrido, Marlen; García-Alvarez, Leticia; García-Portilla, Paz; Bobes, Julio

2014-01-01

Prevention of suicidal behaviour is a public health priority in the European Union. A previous suicide attempt is the best risk predictor for future attempts, as well as completed suicides. The primary aim of this article is to describe a controlled study protocol designed for prevention of recurrent suicidal behaviour that proposes case management, and includes a psychoeducation program, as compared with the standard intervention (PSyMAC). Patients admitted from January 2011 to June 2013 to the emergency room of the Hospital Universitario Central de Asturias were evaluated using a protocol including sociodemographic, psychiatric, and psychosocial assessment. Patients were randomly assigned to either a group receiving continuous case management including participation in a psychoeducation program (experimental group), or a control group receiving standard care. The primary objective is to examine whether or not the period of time until recurrent suicidal behaviour in the experimental group is significantly different from that of the control group. PSyMAC proposes low cost and easily adaptable interventions to the usual clinical setting that can help to compensate the shortcoming of specific action protocols and suicidal behaviour prevention programs in our country. The evaluation of PSyMAC results will determine their real effectivity as a case-magament program to reduce suicidal risk. Copyright © 2013 SEP y SEPB. Published by Elsevier España. All rights reserved.

Towards Implementation of a Generalized Architecture for High-Level Quantum Programming Language

NASA Astrophysics Data System (ADS)

Ameen, El-Mahdy M.; Ali, Hesham A.; Salem, Mofreh M.; Badawy, Mahmoud

2017-08-01

This paper investigates a novel architecture to the problem of quantum computer programming. A generalized architecture for a high-level quantum programming language has been proposed. Therefore, the programming evolution from the complicated quantum-based programming to the high-level quantum independent programming will be achieved. The proposed architecture receives the high-level source code and, automatically transforms it into the equivalent quantum representation. This architecture involves two layers which are the programmer layer and the compilation layer. These layers have been implemented in the state of the art of three main stages; pre-classification, classification, and post-classification stages respectively. The basic building block of each stage has been divided into subsequent phases. Each phase has been implemented to perform the required transformations from one representation to another. A verification process was exposed using a case study to investigate the ability of the compiler to perform all transformation processes. Experimental results showed that the efficacy of the proposed compiler achieves a correspondence correlation coefficient about R ≈ 1 between outputs and the targets. Also, an obvious achievement has been utilized with respect to the consumed time in the optimization process compared to other techniques. In the online optimization process, the consumed time has increased exponentially against the amount of accuracy needed. However, in the proposed offline optimization process has increased gradually.

Evolutionary-based approaches for determining the deviatoric stress of calcareous sands

NASA Astrophysics Data System (ADS)

Shahnazari, Habib; Tutunchian, Mohammad A.; Rezvani, Reza; Valizadeh, Fatemeh

2013-01-01

Many hydrocarbon reservoirs are located near oceans which are covered by calcareous deposits. These sediments consist mainly of the remains of marine plants or animals, so calcareous soils can have a wide variety of engineering properties. Due to their local expansion and considerable differences from terrigenous soils, the evaluation of engineering behaviors of calcareous sediments has been a major concern for geotechnical engineers in recent years. Deviatoric stress is one of the most important parameters directly affecting important shearing characteristics of soils. In this study, a dataset of experimental triaxial tests was gathered from two sources. First, the data of previous experimental studies from the literature were gathered. Then, a series of triaxial tests was performed on calcareous sands of the Persian Gulf to develop the dataset. This work resulted in a large database of experimental results on the maximum deviatoric stress of different calcareous sands. To demonstrate the capabilities of evolutionary-based approaches in modeling the deviatoric stress of calcareous sands, two promising variants of genetic programming (GP), multigene genetic programming (MGP) and gene expression programming (GEP), were applied to propose new predictive models. The models' input parameters were the physical and in-situ condition properties of soil and the output was the maximum deviatoric stress (i.e., the axial-deviator stress). The results of statistical analyses indicated the robustness of these models, and a parametric study was also conducted for further verification of the models, in which the resulting trends were consistent with the results of the experimental study. Finally, the proposed models were further simplified by applying a practical geotechnical correlation.

A novel data hiding scheme for block truncation coding compressed images using dynamic programming strategy

NASA Astrophysics Data System (ADS)

Chang, Ching-Chun; Liu, Yanjun; Nguyen, Son T.

2015-03-01

Data hiding is a technique that embeds information into digital cover data. This technique has been concentrated on the spatial uncompressed domain, and it is considered more challenging to perform in the compressed domain, i.e., vector quantization, JPEG, and block truncation coding (BTC). In this paper, we propose a new data hiding scheme for BTC-compressed images. In the proposed scheme, a dynamic programming strategy was used to search for the optimal solution of the bijective mapping function for LSB substitution. Then, according to the optimal solution, each mean value embeds three secret bits to obtain high hiding capacity with low distortion. The experimental results indicated that the proposed scheme obtained both higher hiding capacity and hiding efficiency than the other four existing schemes, while ensuring good visual quality of the stego-image. In addition, the proposed scheme achieved a low bit rate as original BTC algorithm.

Report of the Plasma Physics and Environmental Perturbation Laboratory (PPEPL) working groups. Volume 3: Magnetospheric experiments working group

NASA Technical Reports Server (NTRS)

1974-01-01

A number of general studies that were proposed for the PPEPL-SHUTTLE program are considered in qualitative detail from both the theoretical and practical points of view. The selection of experimental programs was restricted to those which may be considered active as opposed to refinements of the passive observational programs done previously. It is concluded that, while these new studies were scientifically worthwhile and could be performed in principle, in most cases insufficient attention was paid to the practical details of the experiments. Several specific areas of study, stressing in particular the practical feasibility of the proposed experiments, are recommended. In addition, recommendations are made for further theoretical study, where appropriate. For Vol. 1, see N74-28169; for Vol. 2, see N74-28170.

Elevated temperature crack growth

NASA Technical Reports Server (NTRS)

Malik, S. N.; Vanstone, R. H.; Kim, K. S.; Laflen, J. H.

1987-01-01

The objective of the Elevated Temperature Crack Growth Program is to evaluate proposed nonlinear fracture mechanics methods for application to hot section components of aircraft gas turbine engines. Progress during the past year included linear-elastic fracture mechanics data reduction on nonlinear crack growth rate data on Alloy 718. The bulk of the analytical work centered on thermal gradient problems and proposed fracture mechanics parameters. Good correlation of thermal gradient experimental displacement data and finite element prediction was obtained.

Energy Consumption Forecasting Using Semantic-Based Genetic Programming with Local Search Optimizer.

PubMed

Castelli, Mauro; Trujillo, Leonardo; Vanneschi, Leonardo

2015-01-01

Energy consumption forecasting (ECF) is an important policy issue in today's economies. An accurate ECF has great benefits for electric utilities and both negative and positive errors lead to increased operating costs. The paper proposes a semantic based genetic programming framework to address the ECF problem. In particular, we propose a system that finds (quasi-)perfect solutions with high probability and that generates models able to produce near optimal predictions also on unseen data. The framework blends a recently developed version of genetic programming that integrates semantic genetic operators with a local search method. The main idea in combining semantic genetic programming and a local searcher is to couple the exploration ability of the former with the exploitation ability of the latter. Experimental results confirm the suitability of the proposed method in predicting the energy consumption. In particular, the system produces a lower error with respect to the existing state-of-the art techniques used on the same dataset. More importantly, this case study has shown that including a local searcher in the geometric semantic genetic programming system can speed up the search process and can result in fitter models that are able to produce an accurate forecasting also on unseen data.

Closeout Report for CTEQ Summer School 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, Tao

The CTEQ Collaboration is an informal group of 37 experimental and theoretical high energy physicists from 20 universities and 5 national labs, engaged in a program to advance research in and understanding of QCD. This program includes the well-known collaborative project on global QCD analysis of parton distributions, the organization of a variety of workshops, periodic collaboration meetings, and the subject of this proposal: the CTEQ Summer Schools on QCD Analysis and Phenomenology.

Emissions performance of abatement technologies over the proposed EEC extra-urban driving cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanBeckhoven, L.C.; Rijkeboer, R.C.

1989-01-01

The definition of what is likely to be the new EEC extra-urban cycle has made it possible to determine the emission characteristics of cars fitted with different emissions control equipment. Central to the evaluation program were three versions of experimental lean and dilute burn engines compared with engine modifications and open and closed loop three-way catalyst systems. This paper describes the evaluation program and evaluates its results.

76 FR 10573 - Notice of Proposed Information Collection Requests

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... other will not have experienced the feature (``control''). Average test scores of the two groups will... Promising Features of Teacher Preparation Programs; Phase 1--Recruitment. OMB Control Number: 1850-NEW... baseline student achievement test for an experimental study of the effect on student learning of teachers...

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Trans-Pacific HDR Satellite Communications Experiment Phase-2: Experimental Network and Demonstration Plan

NASA Technical Reports Server (NTRS)

Kadowaki, Naoto; Yoshimura, Naoko; Takahashi, Takashi; Yoshikawa, Makoto; Hsu, Eddie; Bergman, Larry; Bhasin, Kul; Gary, Pat

1998-01-01

The trans-Pacific high data rate (TP-HDR) satellite communications experiment was proposed at the Japan-U.S. Cooperation in Space (JUCS) Program Workshop held in Hawaii in 1993 and remote high definition video post-production was demonstrated as the first phase trial. Following the first phase, the second phase experiment is currently prepared. This paper describes the experimental network configuration, application demonstration, and performance evaluation plan of the second phase experiment.

The multi-scattering model for calculations of positron spatial distribution in the multilayer stacks, useful for conventional positron measurements

NASA Astrophysics Data System (ADS)

Dryzek, Jerzy; Siemek, Krzysztof

2013-08-01

The spatial distribution of positrons emitted from radioactive isotopes into stacks or layered samples is a subject of the presented report. It was found that Monte Carlo (MC) simulations using GEANT4 code are not able to describe correctly the experimental data of the positron fractions in stacks. The mathematical model was proposed for calculations of the implantation profile or positron fractions in separated layers or foils being components of a stack. The model takes into account only two processes, i.e., the positron absorption and backscattering at interfaces. The mathematical formulas were applied in the computer program called LYS-1 (layers profile analysis). The theoretical predictions of the model were in the good agreement with the results of the MC simulations for the semi infinite sample. The experimental verifications of the model were performed on the symmetrical and non-symmetrical stacks of different foils. The good agreement between the experimental and calculated fractions of positrons in components of a stack was achieved. Also the experimental implantation profile obtained using the depth scanning of positron implantation technique is very well described by the theoretical profile obtained within the proposed model. The LYS-1 program allows us also to calculate the fraction of positrons which annihilate in the source, which can be useful in the positron spectroscopy.

The Student Spaceflight Experiments Program: Access to the ISS for K-14 Students

NASA Astrophysics Data System (ADS)

Livengood, Timothy A.; Goldstein, J. J.; Hamel, S.; Manber, J.; Hulslander, M.

2013-10-01

The Student Spaceflight Experiments Program (SSEP) has flown 53 experiments to space, on behalf of students from middle school through community college, on 4 missions: each of the last 2 Space Shuttle flights, the first SpaceX demonstration flight to the International Space Station (ISS), and on SpaceX-1 to ISS. Two more missions to ISS have payloads flying in Fall 2013. SSEP plans 2 missions to the ISS per year for the foreseeable future, and is expanding the program to include 4-year undergraduate college students and home-schooled students. SSEP experiments have explored biological, chemical, and physical phenomena within self-contained enclosures developed by NanoRacks, currently in the form of MixStix Fluid Mixing Enclosures. 21,600 students participated in the initial 6 missions of SSEP, directly experiencing the entire lifecycle of space science experimentation through community-wide participation in SSEP, taking research from a nascent idea through developing competitive research proposals, down-selecting to three proposals from each participating community and further selection of a single proposal for flight, actual space flight, sample recovery, analysis, and reporting. The National Air and Space Museum has hosted 3 National Conferences for SSEP student teams to report results in keeping with the model of professional research. Student teams have unflinchingly reported on success, failure, and groundbased efforts to develop proposals for future flight opportunities. Community participation extends outside the sciences and the immediate proposal efforts to include design competitions for mission patches, which also fly to space. Student experimenters have rallied around successful proposal teams to support a successful experiment on behalf of the entire community. SSEP is a project of the National Center for Earth and Space Science Education enabled through NanoRacks LLC, working in partnership with NASA under a Space Act Agreement as part of the utilization of the International Space Station as a National Laboratory.

FIREX mission requirements document for nonrenewable resources

NASA Technical Reports Server (NTRS)

Dixon, T.; Carsey, F.

1982-01-01

The proposed mission requirements and a proposed experimental program for satellite synthetic aperture radar (SAR) system named FIREX (Free-Flying Imaging Radar Experiment) for nonrenewable resources is described. The recommended spacecraft minimum SAR system is a C-band imager operating in four modes: (1) low look angle HH-polarized; (2) intermediate look angle, HH-polarized; (3) intermediate look angle, IIV-polarized; and (4) high look angle HH-polarized. This SAR system is complementary to other future spaceborne imagers such as the Thematic Mapper on LANDSAT-D. A near term aircraft SAR based research program is outlined which addresses specific mission design issues such as preferred incidence angles or polarizations for geologic targets of interest.

Design and implementation of EP-based PID controller for chaos synchronization of Rikitake circuit systems.

PubMed

Hou, Yi-You

2017-09-01

This article addresses an evolutionary programming (EP) algorithm technique-based and proportional-integral-derivative (PID) control methods are established to guarantee synchronization of the master and slave Rikitake chaotic systems. For PID synchronous control, the evolutionary programming (EP) algorithm is used to find the optimal PID controller parameters k p , k i , k d by integrated absolute error (IAE) method for the convergence conditions. In order to verify the system performance, the basic electronic components containing operational amplifiers (OPAs), resistors, and capacitors are used to implement the proposed chaotic Rikitake systems. Finally, the experimental results validate the proposed Rikitake chaotic synchronization approach. Copyright © 2017. Published by Elsevier Ltd.

PRP Comments for ICF Q1/Q2 FY17 Experiments 3/10/16

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kauffman, R.

2016-04-14

The PRP generally endorsed the Program plan during the short time for discussions. We agree that the strategy to develop a hohlraum that is symmetric and has low laser-plasma instabilities and to develop an alternative method for supporting the capsule is the best path forward for making progress in understanding ignition performance. The Program is oriented toward a milestone in 2020 for “determining the efficacy of NIF for ignition and credible physics-scaling to multi-megajoule yields for all ICF approaches.” We are concerned that the time and resources are not sufficient to vet all of the various approaches that are beingmore » pursued to make an informed decision by this date. For NIF to meet this goal, a process will be needed to to select the most promising paths forward. We recommend that the Program develop this process for selecting the path forward to optimize resources. We were glad to see that the direct drive program took our comments under consideration. We think that the proposed experiments have the program headed in a better direction. The PRP had only a short time to discuss the detailed experimental proposals. The following are comments on the detailed proposals. We did not have time to discuss them as a group. They represent individual opinions and provided to you as feedback to your proposals.« less

A classification of components of workplace disability management programs: results from a systematic review.

PubMed

Gensby, U; Labriola, M; Irvin, E; Amick, B C; Lund, T

2014-06-01

This paper presents results from a Campbell systematic review on the nature and effectiveness of workplace disability management programs (WPDM) promoting return to work (RTW), as implemented and practiced by employers. A classification of WPDM program components, based on the review results, is proposed. Twelve databases were searched between 1948 to July 2010 for peer-reviewed studies of WPDM programs provided by employers to re-entering workers with occupational or non-occupational illnesses or injuries. Screening of articles, risk of bias assessment and data extraction were conducted in pairs of reviewers. Studies were clustered around various dimensions of the design and context of programs. 16,932 records were identified by the initial search. 599 papers were assessed for relevance. Thirteen studies met inclusion criteria. Twelve peer reviewed articles (two non-randomized studies, and ten single group experimental before and after studies), including ten different WPDM programs informed the synthesis of results. Narrative descriptions of the included program characteristics provided insight on program scope, components, procedures and human resources involved. However, there were insufficient data on the characteristics of the sample and the effect sizes were uncertain. A taxonomy classifying policies and practices around WPDM programs is proposed. There is insufficient evidence to draw conclusions on the effectiveness of employer provided WPDM programs promoting RTW. It was not possible to determine if specific program components or specific sets of components are driving effectiveness. The proposed taxonomy may guide future WPDM program evaluation and clarify the setup of programs offered to identify gaps in existing company strategies.

77 FR 40064 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

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76 FR 338 - Notice of Proposed Information Collection Requests

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... feasibility of a promising practices study of Upward Bound that uses a rigorous quasi-experimental design. The design and feasibility report will develop a set of design options for conducting a study of Upward Bound and examine their applicability to studies of other TRIO programs. If a rigorous evaluation design...

Proposed experimental programs for testing remote sensor applications in the metropolitan Washington area

NASA Technical Reports Server (NTRS)

Mallon, H. J.; Howard, J. Y.

1972-01-01

A group of suggested experiments is described, which are to be conducted with ERTS-A and high altitude aircraft imagery during the 1972 period. Methods of analysis and observation of land use, urban change, transportation, and possible pollution, using small scale, low resolution data, are discussed.

Real-time supervisor system based on trinary logic to control experiments with behaving animals and humans.

PubMed

Kutz, D F; Marzocchi, N; Fattori, P; Cavalcanti, S; Galletti, C

2005-06-01

A new method is presented based on trinary logic able to check the state of different control variables and synchronously record the physiological and behavioral data of behaving animals and humans. The basic information structure of the method is a time interval of defined maximum duration, called time slice, during which the supervisor system periodically checks the status of a specific subset of input channels. An experimental condition is a sequence of time slices subsequently executed according to the final status of the previous time slice. The proposed method implements in its data structure the possibility to branch like an if-else cascade and the possibility to repeat parts of it recursively like the while-loop. Therefore its data structure contains the most basic control structures of programming languages. The method was implemented using a real-time version of LabVIEW programming environment to program and control our experimental setup. Using this supervision system, we synchronously record four analog data channels at 500 Hz (including eye movements) and the time stamps of up to six neurons at 100 kHz. The system reacts with a resolution within 1 ms to changes of state of digital input channels. The system is set to react to changes in eye position with a resolution within 4 ms. The time slices, experimental conditions, and data are handled by relational databases. This facilitates the construction of new experimental conditions and data analysis. The proposed implementation allows continuous recording without an inter-trial gap for data storage or task management. The implementation can be used to drive electrophysiological experiments of behaving animals and psychophysical studies with human subjects.

A research program in magnetogasdynamics utilizing hypervelocity coaxial plasma generators

NASA Technical Reports Server (NTRS)

Spight, C.

1976-01-01

A broadly-gauged research program in magnetogasdynamics utilizing hypervelocity coaxial plasma generators is presented. A complete hypervelocity coaxial plasma generator facility was assembled and tested. Significant progress was made in the direction of understanding the important processes in the interaction of hypervelocity MGD flow with transverse applied fields. It is now proposed to utilize the accumulated experimental capability and theoretical analysis in application to the analysis and design parameterization of pulsed magnetogasdynamic direct energy convertor configurations.

Total focusing method with correlation processing of antenna array signals

NASA Astrophysics Data System (ADS)

Kozhemyak, O. A.; Bortalevich, S. I.; Loginov, E. L.; Shinyakov, Y. A.; Sukhorukov, M. P.

2018-03-01

The article proposes a method of preliminary correlation processing of a complete set of antenna array signals used in the image reconstruction algorithm. The results of experimental studies of 3D reconstruction of various reflectors using and without correlation processing are presented in the article. Software ‘IDealSystem3D’ by IDeal-Technologies was used for experiments. Copper wires of different diameters located in a water bath were used as a reflector. The use of correlation processing makes it possible to obtain more accurate reconstruction of the image of the reflectors and to increase the signal-to-noise ratio. The experimental results were processed using an original program. This program allows varying the parameters of the antenna array and sampling frequency.

A Preliminary Investigation of Hall Thruster Technology

NASA Technical Reports Server (NTRS)

Gallimore, Alec D.

1997-01-01

A three-year, NASA/BMDO-sponsored experimental program to conduct performance and plume plasma property measurements on two Russian Stationary Plasma Thrusters (SPTs) has been completed. The program utilized experimental facilitates at the University of Michigan's Plasmadynamics and Electric Propulsion Laboratory (PEPL). The main features of the proposed effort were as follows: We Characterized Hall thruster [and arcjet] performance by measuring ion exhaust velocity with probes at various thruster conditions. Used a variety of probe diagnostics in the thruster plume to measure plasma properties and flow properties including T(sub e) and n(sub e), ion current density and ion energy distribution, and electric fields by mapping plasma potential. Used emission spectroscopy to identify species within the plume and to measure electron temperatures.

Automatic recognition of postural allocations.

PubMed

Sazonov, Edward; Krishnamurthy, Vidya; Makeyev, Oleksandr; Browning, Ray; Schutz, Yves; Hill, James

2007-01-01

A significant part of daily energy expenditure may be attributed to non-exercise activity thermogenesis and exercise activity thermogenesis. Automatic recognition of postural allocations such as standing or sitting can be used in behavioral modification programs aimed at minimizing static postures. In this paper we propose a shoe-based device and related pattern recognition methodology for recognition of postural allocations. Inexpensive technology allows implementation of this methodology as a part of footwear. The experimental results suggest high efficiency and reliability of the proposed approach.

Gene Function Hypotheses for the Campylobacter jejuni Glycome Generated by a Logic-Based Approach

PubMed Central

Sternberg, Michael J.E.; Tamaddoni-Nezhad, Alireza; Lesk, Victor I.; Kay, Emily; Hitchen, Paul G.; Cootes, Adrian; van Alphen, Lieke B.; Lamoureux, Marc P.; Jarrell, Harold C.; Rawlings, Christopher J.; Soo, Evelyn C.; Szymanski, Christine M.; Dell, Anne; Wren, Brendan W.; Muggleton, Stephen H.

2013-01-01

Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. Specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empirical data with respect to logically encoded background knowledge. We study the capsular polysaccharide biosynthetic pathway of the major human gastrointestinal pathogen Campylobacter jejuni. We consider several key steps in the formation of capsular polysaccharide consisting of 15 genes of which 8 have assigned function, and we explore the extent to which functions can be hypothesised for the remaining 7. Two sources of experimental data provide the information for learning—the results of knockout experiments on the genes involved in capsule formation and the absence/presence of capsule genes in a multitude of strains of different serotypes. The machine learning uses the pathway structure as background knowledge. We propose assignments of specific genes to five previously unassigned reaction steps. For four of these steps, there was an unambiguous optimal assignment of gene to reaction, and to the fifth, there were three candidate genes. Several of these assignments were consistent with additional experimental results. We therefore show that the logic-based methodology provides a robust strategy to integrate results from different experimental approaches and propose hypotheses for the behaviour of a biological system. PMID:23103756

Gene function hypotheses for the Campylobacter jejuni glycome generated by a logic-based approach.

PubMed

Sternberg, Michael J E; Tamaddoni-Nezhad, Alireza; Lesk, Victor I; Kay, Emily; Hitchen, Paul G; Cootes, Adrian; van Alphen, Lieke B; Lamoureux, Marc P; Jarrell, Harold C; Rawlings, Christopher J; Soo, Evelyn C; Szymanski, Christine M; Dell, Anne; Wren, Brendan W; Muggleton, Stephen H

2013-01-09

Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. Specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empirical data with respect to logically encoded background knowledge. We study the capsular polysaccharide biosynthetic pathway of the major human gastrointestinal pathogen Campylobacter jejuni. We consider several key steps in the formation of capsular polysaccharide consisting of 15 genes of which 8 have assigned function, and we explore the extent to which functions can be hypothesised for the remaining 7. Two sources of experimental data provide the information for learning-the results of knockout experiments on the genes involved in capsule formation and the absence/presence of capsule genes in a multitude of strains of different serotypes. The machine learning uses the pathway structure as background knowledge. We propose assignments of specific genes to five previously unassigned reaction steps. For four of these steps, there was an unambiguous optimal assignment of gene to reaction, and to the fifth, there were three candidate genes. Several of these assignments were consistent with additional experimental results. We therefore show that the logic-based methodology provides a robust strategy to integrate results from different experimental approaches and propose hypotheses for the behaviour of a biological system. Copyright © 2012 Elsevier Ltd. All rights reserved.

Solving large-scale fixed cost integer linear programming models for grid-based location problems with heuristic techniques

NASA Astrophysics Data System (ADS)

Noor-E-Alam, Md.; Doucette, John

2015-08-01

Grid-based location problems (GBLPs) can be used to solve location problems in business, engineering, resource exploitation, and even in the field of medical sciences. To solve these decision problems, an integer linear programming (ILP) model is designed and developed to provide the optimal solution for GBLPs considering fixed cost criteria. Preliminary results show that the ILP model is efficient in solving small to moderate-sized problems. However, this ILP model becomes intractable in solving large-scale instances. Therefore, a decomposition heuristic is proposed to solve these large-scale GBLPs, which demonstrates significant reduction of solution runtimes. To benchmark the proposed heuristic, results are compared with the exact solution via ILP. The experimental results show that the proposed method significantly outperforms the exact method in runtime with minimal (and in most cases, no) loss of optimality.

A Shellcode Detection Method Based on Full Native API Sequence and Support Vector Machine

NASA Astrophysics Data System (ADS)

Cheng, Yixuan; Fan, Wenqing; Huang, Wei; An, Jing

2017-09-01

Dynamic monitoring the behavior of a program is widely used to discriminate between benign program and malware. It is usually based on the dynamic characteristics of a program, such as API call sequence or API call frequency to judge. The key innovation of this paper is to consider the full Native API sequence and use the support vector machine to detect the shellcode. We also use the Markov chain to extract and digitize Native API sequence features. Our experimental results show that the method proposed in this paper has high accuracy and low detection rate.

Advanced educational program in optoelectronics for undergraduates and graduates in electronics

NASA Astrophysics Data System (ADS)

Vladescu, Marian; Schiopu, Paul

2015-02-01

The optoelectronics education included in electronics curricula at Faculty of Electronics, Telecommunications and Information Technology of "Politehnica" University of Bucharest started in early '90s, and evolved constantly since then, trying to address the growing demand of engineers with a complex optoelectronics profile and to meet the increased requirements of microelectronics, optoelectronics, and lately nanotechnologies. Our goal is to provide a high level of theoretical background combined with advanced experimental tools in laboratories, and also with simulation platforms. That's why we propose an advanced educational program in optoelectronics for both grades of our study program, bachelor and master.

Optimization Techniques for Analysis of Biological and Social Networks

DTIC Science & Technology

2012-03-28

analyzing a new metaheuristic technique, variable objective search. 3. Experimentation and application: Implement the proposed algorithms , test and fine...alternative mathematical programming formulations, their theoretical analysis, the development of exact algorithms , and heuristics. Originally, clusters...systematic fashion under a unifying theoretical and algorithmic framework. Optimization, Complex Networks, Social Network Analysis, Computational

Improving Moral Reasoning among College Students: A Game-Based Learning Approach

ERIC Educational Resources Information Center

Huang, Wenyeh; Ho, Jonathan C.

2018-01-01

Considering a company's limited time and resources, an effective training method that improves employees' ability to make ethical decision is needed. Based on social cognitive theory, this study proposes that employing games in an ethics training program can help improve moral reasoning through actively engaging learners. The experimental design…

Vibration isolation technology - An executive summary of systems development and demonstration. [for proposed microgravity experiments aboard STS and Space Station Freedom

NASA Technical Reports Server (NTRS)

Grodsinsky, C. M.; Logsdon, K. A.; Lubomski, J. F.

1993-01-01

A program was organized to develop the enabling technologies needed for the use of Space Station Freedom as a viable microgravity experimental platform. One of these development programs was the Vibration Isolation Technology (VIT). This technology development program grew because of increased awareness that the acceleration disturbances present on the Space Transportation System (STS) orbiter can and are detrimental to many microgravity experiments proposed for STS, and in the future, Space Station Freedom (SSF). Overall technological organization are covered of the VIT program. Emphasis is given to the results from development and demonstration of enabling technologies to achieve the acceleration requirements perceived as those most likely needed for a variety of microgravity science experiments. In so doing, a brief summary of general theoretical approaches to controlling the acceleration environment of an isolated space based payload and the design and/or performance of two prototype six degree of freedom active magnetic isolation systems is presented.

The Cognitive and Motivation Intervention Program in Youth Female Volleyball Players.

PubMed

Claver, Fernando; Jiménez, Ruth; Gil-Arias, Alexander; Moreno, Alberto; Moreno, M Perla

2017-10-01

This study, grounded in Self-Determination Theory (Deci and Ryan, 1985, 2002) was aimed to determine the influence of a cognitive-motivational intervention program, to improve the basic psychological need satisfaction of autonomy and competence, autonomous motivation, procedural knowledge, perceived performance and sport commitment, in youth volleyball players. Participants included 34 Under-19 female volleyball players. A quasi-experimental design was carried out with an experimental group (n = 16; M = 17.45; SD = .45) and a control group (n = 18; M = 16.64; SD = .70). The experimental group followed a multidimensional intervention program comprised of 24 sessions held over three months (two training sessions per week). It was based on two strategies: giving athletes the possibility of choice in specific training tasks (proposing training situations with several action alternatives) and questioning (cognitively involving players through tactical questions). A repeated-measures MANOVA 2 (group: experimental and control) x 2 (time: pre-test and post-test) was used to analyse the effect of Group x Time interaction. The results of the inter-group analysis showed significant differences in the post-test measurement between the experimental group and the control group (in favour of the experimental group) in the variables: basic psychological need satisfaction of autonomy and competence, autonomous motivation, procedural knowledge, perceived performance and sport commitment. Given the relevance of the cognitive-motivational processes, not only for performance but also for sport commitment, this intervention has important implications for sport coaching.

Hybrid Spintronic-CMOS Spiking Neural Network with On-Chip Learning: Devices, Circuits, and Systems

NASA Astrophysics Data System (ADS)

Sengupta, Abhronil; Banerjee, Aparajita; Roy, Kaushik

2016-12-01

Over the past decade, spiking neural networks (SNNs) have emerged as one of the popular architectures to emulate the brain. In SNNs, information is temporally encoded and communication between neurons is accomplished by means of spikes. In such networks, spike-timing-dependent plasticity mechanisms require the online programing of synapses based on the temporal information of spikes transmitted by spiking neurons. In this work, we propose a spintronic synapse with decoupled spike-transmission and programing-current paths. The spintronic synapse consists of a ferromagnet-heavy-metal heterostructure where the programing current through the heavy metal generates spin-orbit torque to modulate the device conductance. Low programing energy and fast programing times demonstrate the efficacy of the proposed device as a nanoelectronic synapse. We perform a simulation study based on an experimentally benchmarked device-simulation framework to demonstrate the interfacing of such spintronic synapses with CMOS neurons and learning circuits operating in the transistor subthreshold region to form a network of spiking neurons that can be utilized for pattern-recognition problems.

Object matching using a locally affine invariant and linear programming techniques.

PubMed

Li, Hongsheng; Huang, Xiaolei; He, Lei

2013-02-01

In this paper, we introduce a new matching method based on a novel locally affine-invariant geometric constraint and linear programming techniques. To model and solve the matching problem in a linear programming formulation, all geometric constraints should be able to be exactly or approximately reformulated into a linear form. This is a major difficulty for this kind of matching algorithm. We propose a novel locally affine-invariant constraint which can be exactly linearized and requires a lot fewer auxiliary variables than other linear programming-based methods do. The key idea behind it is that each point in the template point set can be exactly represented by an affine combination of its neighboring points, whose weights can be solved easily by least squares. Errors of reconstructing each matched point using such weights are used to penalize the disagreement of geometric relationships between the template points and the matched points. The resulting overall objective function can be solved efficiently by linear programming techniques. Our experimental results on both rigid and nonrigid object matching show the effectiveness of the proposed algorithm.

Program Code Generator for Cardiac Electrophysiology Simulation with Automatic PDE Boundary Condition Handling

PubMed Central

Punzalan, Florencio Rusty; Kunieda, Yoshitoshi; Amano, Akira

2015-01-01

Clinical and experimental studies involving human hearts can have certain limitations. Methods such as computer simulations can be an important alternative or supplemental tool. Physiological simulation at the tissue or organ level typically involves the handling of partial differential equations (PDEs). Boundary conditions and distributed parameters, such as those used in pharmacokinetics simulation, add to the complexity of the PDE solution. These factors can tailor PDE solutions and their corresponding program code to specific problems. Boundary condition and parameter changes in the customized code are usually prone to errors and time-consuming. We propose a general approach for handling PDEs and boundary conditions in computational models using a replacement scheme for discretization. This study is an extension of a program generator that we introduced in a previous publication. The program generator can generate code for multi-cell simulations of cardiac electrophysiology. Improvements to the system allow it to handle simultaneous equations in the biological function model as well as implicit PDE numerical schemes. The replacement scheme involves substituting all partial differential terms with numerical solution equations. Once the model and boundary equations are discretized with the numerical solution scheme, instances of the equations are generated to undergo dependency analysis. The result of the dependency analysis is then used to generate the program code. The resulting program code are in Java or C programming language. To validate the automatic handling of boundary conditions in the program code generator, we generated simulation code using the FHN, Luo-Rudy 1, and Hund-Rudy cell models and run cell-to-cell coupling and action potential propagation simulations. One of the simulations is based on a published experiment and simulation results are compared with the experimental data. We conclude that the proposed program code generator can be used to generate code for physiological simulations and provides a tool for studying cardiac electrophysiology. PMID:26356082

Support for Synchrotron Access by Environmental Scientists

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daly, Michael; Madden, Andrew; Palumbo, Anthony

2006-06-01

To support ERSP-funded scientists in all aspects of synchrotron-based research at the Advanced Photon Source (APS). This support comes in one or more of the following forms: (1) writing proposals to the APS General User (GU) program, (2) providing time at MRCAT/EnviroCAT beamlines via the membership of the Molecular Environmental Science (MES) Group in MRCAT/EnviroCAT, (3) assistance in experimental design and sample preparation, (4) support at the beamline during the synchrotron experiment, (5) analysis and interpretation of the synchrotron data, and (6) integration of synchrotron experimental results into manuscripts.

LDA-Based Unified Topic Modeling for Similar TV User Grouping and TV Program Recommendation.

PubMed

Pyo, Shinjee; Kim, Eunhui; Kim, Munchurl

2015-08-01

Social TV is a social media service via TV and social networks through which TV users exchange their experiences about TV programs that they are viewing. For social TV service, two technical aspects are envisioned: grouping of similar TV users to create social TV communities and recommending TV programs based on group and personal interests for personalizing TV. In this paper, we propose a unified topic model based on grouping of similar TV users and recommending TV programs as a social TV service. The proposed unified topic model employs two latent Dirichlet allocation (LDA) models. One is a topic model of TV users, and the other is a topic model of the description words for viewed TV programs. The two LDA models are then integrated via a topic proportion parameter for TV programs, which enforces the grouping of similar TV users and associated description words for watched TV programs at the same time in a unified topic modeling framework. The unified model identifies the semantic relation between TV user groups and TV program description word groups so that more meaningful TV program recommendations can be made. The unified topic model also overcomes an item ramp-up problem such that new TV programs can be reliably recommended to TV users. Furthermore, from the topic model of TV users, TV users with similar tastes can be grouped as topics, which can then be recommended as social TV communities. To verify our proposed method of unified topic-modeling-based TV user grouping and TV program recommendation for social TV services, in our experiments, we used real TV viewing history data and electronic program guide data from a seven-month period collected by a TV poll agency. The experimental results show that the proposed unified topic model yields an average 81.4% precision for 50 topics in TV program recommendation and its performance is an average of 6.5% higher than that of the topic model of TV users only. For TV user prediction with new TV programs, the average prediction precision was 79.6%. Also, we showed the superiority of our proposed model in terms of both topic modeling performance and recommendation performance compared to two related topic models such as polylingual topic model and bilingual topic model.

A theoretical study of optical contact of vitreous silica

NASA Technical Reports Server (NTRS)

Barber, T. D.

1972-01-01

Optical contact has been proposed as a method of bonding quartz parts of the Stanford relativity satellite. The theory of the van der Waals force is outlined and applied to the problem of optical contact. The effect of various contaminations is discussed and a program of experimentation for further study of the problem is presented.

Using Reading Circles Strategy for Developing Preparatory Students' Critical Reading Skills and Social Skills

ERIC Educational Resources Information Center

Abdelrasoul, Mohamed Mahmoud Ibrahim

2014-01-01

The present study aimed at developing the necessary critical reading skills and social skills of the Egyptian EFL second year preparatory school students, through a proposed program based on using reading circles strategy. The study participants were 44 students from Sohag Experimental Preparatory School in Sohag Governorate. Instruments of the…

Selection of Behavior Modification Programs Using the Simultaneous Treatment Design: Two Case Studies.

ERIC Educational Resources Information Center

Lowe, Warren C.

This report outlines the limitations and weaknesses of singlecase, time-series research designs, of which the ABAB design is one of the widely used. An alternative design, the simultaneous treatment design, proposed by Browning and Stover (1971), has several advantages over the ABAB design. The design enables an experimenter to simultaneously…

Status of the VEGA Project

NASA Astrophysics Data System (ADS)

Kamanin, D. V.; Alexandrov, A. A.; Alexandrova, I. A.; Kondtatyev, N. A.; Kuznetsova, E. A.; Shvetsov, V. N.; Strekalovsky, A. O.; Strekalovsky, O. V.; Zhuchko, V. E.; Pyatkov, Yu. V.; Jacobs, N.; Malaza, V.

2015-06-01

Motivation and status of the VEGA (Velocity-Energy Guide based Array) project is presented. One armed fission fragments spectrometer with an electrostatic guide system is proposed for installation at the vertical experimental channel of the IBR-2 reactor. Scientific program aimed at investigation of new multi-body decays of actinides, shapeisomeric states in fission fragments and fission modes is reported.

The Student Spaceflight Experiments Program: Access to the ISS for K-14 Students

NASA Astrophysics Data System (ADS)

Livengood, T. A.; Goldstein, J. J.; Hamel, S.; Manber, J.; Hulslander, M.

2013-12-01

The Student Spaceflight Experiments Program (SSEP) has flown 53 experiments to space, on behalf of students from middle school through community college, on 4 missions: each of the last 2 Space Shuttle flights, the first SpaceX demonstration flight to the International Space Station (ISS), and on SpaceX-1 to ISS. Two more missions to ISS have payloads flying in Fall 2013. SSEP plans 2 missions to the ISS per year for the foreseeable future, and is expanding the program to include 4-year undergraduate college students and home-schooled students. SSEP experiments have explored biological, chemical, and physical phenomena within self-contained enclosures developed by NanoRacks, currently in the form of MixStix Fluid Mixing Enclosures. 21,600 students participated in the initial 6 missions of SSEP, directly experiencing the entire lifecycle of space science experimentation through community-wide participation in SSEP, taking research from a nascent idea through developing competitive research proposals, down-selecting to three proposals from each participating community and further selection of a single proposal for flight, actual space flight, sample recovery, analysis, and reporting. The National Air and Space Museum has hosted 3 National Conferences for SSEP student teams to report results in keeping with the model of professional research. Student teams have unflinchingly reported on success, failure, and groundbased efforts to develop proposals for future flight opportunities. Community participation extends outside the sciences and the immediate proposal efforts to include design competitions for mission patches, which also fly to space. Student experimenters have rallied around successful proposal teams to support a successful experiment on behalf of the entire community. SSEP is a project of the National Center for Earth and Space Science Education enabled through NanoRacks LLC, working in partnership with NASA under a Space Act Agreement as part of the utilization of the International Space Station as a National Laboratory. 2012 Oct 06 - Astronaut Sunita Williams operating a Fluid Mixing Enclosure during SSEP Mission 2 on the International Space Station.

Python to learn programming

NASA Astrophysics Data System (ADS)

Bogdanchikov, A.; Zhaparov, M.; Suliyev, R.

2013-04-01

Today we have a lot of programming languages that can realize our needs, but the most important question is how to teach programming to beginner students. In this paper we suggest using Python for this purpose, because it is a programming language that has neatly organized syntax and powerful tools to solve any task. Moreover it is very close to simple math thinking. Python is chosen as a primary programming language for freshmen in most of leading universities. Writing code in python is easy. In this paper we give some examples of program codes written in Java, C++ and Python language, and we make a comparison between them. Firstly, this paper proposes advantages of Python language in relation to C++ and JAVA. Then it shows the results of a comparison of short program codes written in three different languages, followed by a discussion on how students understand programming. Finally experimental results of students' success in programming courses are shown.

Predicting the Coupling Properties of Axially-Textured Materials.

PubMed

Fuentes-Cobas, Luis E; Muñoz-Romero, Alejandro; Montero-Cabrera, María E; Fuentes-Montero, Luis; Fuentes-Montero, María E

2013-10-30

A description of methods and computer programs for the prediction of "coupling properties" in axially-textured polycrystals is presented. Starting data are the single-crystal properties, texture and stereography. The validity and proper protocols for applying the Voigt, Reuss and Hill approximations to estimate coupling properties effective values is analyzed. Working algorithms for predicting mentioned averages are given. Bunge's symmetrized spherical harmonics expansion of orientation distribution functions, inverse pole figures and (single and polycrystals) physical properties is applied in all stages of the proposed methodology. The established mathematical route has been systematized in a working computer program. The discussion of piezoelectricity in a representative textured ferro-piezoelectric ceramic illustrates the application of the proposed methodology. Polycrystal coupling properties, predicted by the suggested route, are fairly close to experimentally measured ones.

Predicting the Coupling Properties of Axially-Textured Materials

PubMed Central

Fuentes-Cobas, Luis E.; Muñoz-Romero, Alejandro; Montero-Cabrera, María E.; Fuentes-Montero, Luis; Fuentes-Montero, María E.

2013-01-01

A description of methods and computer programs for the prediction of “coupling properties” in axially-textured polycrystals is presented. Starting data are the single-crystal properties, texture and stereography. The validity and proper protocols for applying the Voigt, Reuss and Hill approximations to estimate coupling properties effective values is analyzed. Working algorithms for predicting mentioned averages are given. Bunge’s symmetrized spherical harmonics expansion of orientation distribution functions, inverse pole figures and (single and polycrystals) physical properties is applied in all stages of the proposed methodology. The established mathematical route has been systematized in a working computer program. The discussion of piezoelectricity in a representative textured ferro-piezoelectric ceramic illustrates the application of the proposed methodology. Polycrystal coupling properties, predicted by the suggested route, are fairly close to experimentally measured ones. PMID:28788370

Use of virtual reality intervention to improve reaction time in children with cerebral palsy: A randomized controlled trial.

PubMed

Pourazar, Morteza; Mirakhori, Fatemeh; Hemayattalab, Rasool; Bagherzadeh, Fazlolah

2017-09-21

The purpose of this study was to investigate the training effects of Virtual Reality (VR) intervention program on reaction time in children with cerebral palsy. Thirty boys ranging from 7 to 12 years (mean = 11.20; SD = .76) were selected by available sampling method and randomly divided into the experimental and control groups. Simple Reaction Time (SRT) and Discriminative Reaction Time (DRT) were measured at baseline and 1 day after completion of VR intervention. Multivariate analysis of variance (MANOVA) and paired sample t-test were performed to analyze the results. MANOVA test revealed significant effects for group in posttest phase, with lower reaction time in both measures for the experimental group. Based on paired sample t-test results, both RT measures significantly improved in experimental group following the VR intervention program. This paper proposes VR as a promising tool into the rehabilitation process for improving reaction time in children with cerebral palsy.

X-38 Experimental Aeroheating at Mach 10

NASA Technical Reports Server (NTRS)

Berry, Scott A.; Horvath, Thomas J.; Weilmuenster, K. James; Alter, Stephan J.; Merski, N. Ronald

2001-01-01

This report provides an update of the hypersonic aerothermodynamic wind tunnel test program conducted at the NASA Langley Research Center in support of the X-38 program. Global surface heat transfer distributions were measured on 0.0177 and 0.0236 scale models of the proposed X-38 configuration at Mach 10 in air. The parametrics that were investigated primarily include freestream unit Reynolds numbers of 0.6 to 2.2 million per foot and body flap deflections of 15, 20, and 25 deg for an angle-of-attack of 40 deg. The model-scale variance was tested to obtain laminar, transitional, and turbulent heating levels on the defected bodyflaps. In addition, a limited investigation of forced boundary layer transition through the use of discrete roughness elements was performed. Comparisons of the present experimental results to computational predictions and previous experimental data were conducted Laminar, transitional, and turbulent heating levels were observed on the deflected body flap, which compared favorably to the computational results and to the predicted heating based on the flight aerothermodynamic database.

X-34 Experimental Aeroheating at Mach 6 and 10

NASA Technical Reports Server (NTRS)

Berry, Scott A.; Horvath, Thomas J.; DiFulvio, Michael; Glass, Christopher; Merski, N. Ronald

1998-01-01

Critical technologies are being developed to support the goals of the NASA Office of Aeronautics and Space Transportation Technology Access to Space initiative for next-generation reusable space transportation systems. From the perspective of aerothermodynamic performance throughout the flight trajectory, the Reusable Launch Vehicle program incorporates conceptual analysis, ground-based testing, and computational fluid dynamics to provide flyable suborbital flight demonstrator vehicles. This report provides an overview of the hypersonic aeroheating wind tunnel test program conducted at the NASA Langley Research Center in support of one of these vehicles, the X-34 small reusable technology demonstrator program. Global surface heat transfer images, surface streamline patterns, and shock shapes were measured on 0.0153- and 0.0183-scale models of proposed X-34 flight vehicles at Mach 6 and 10 in air. The primary parametrics that were investigated include angles-of-attack from 0 to 35 deg. and freestream unit Reynolds numbers from 0.5 to 8 million per foot (which was sufficient to produce laminar, transitional, and turbulent heating data), both with and without control surface deflections. Comparisons of the experimental data to computational predictions are included, along with a discussion of the implications of some of the experimental flow features for the flight vehicle.

Workflow of the Grover algorithm simulation incorporating CUDA and GPGPU

NASA Astrophysics Data System (ADS)

Lu, Xiangwen; Yuan, Jiabin; Zhang, Weiwei

2013-09-01

The Grover quantum search algorithm, one of only a few representative quantum algorithms, can speed up many classical algorithms that use search heuristics. No true quantum computer has yet been developed. For the present, simulation is one effective means of verifying the search algorithm. In this work, we focus on the simulation workflow using a compute unified device architecture (CUDA). Two simulation workflow schemes are proposed. These schemes combine the characteristics of the Grover algorithm and the parallelism of general-purpose computing on graphics processing units (GPGPU). We also analyzed the optimization of memory space and memory access from this perspective. We implemented four programs on CUDA to evaluate the performance of schemes and optimization. Through experimentation, we analyzed the organization of threads suited to Grover algorithm simulations, compared the storage costs of the four programs, and validated the effectiveness of optimization. Experimental results also showed that the distinguished program on CUDA outperformed the serial program of libquantum on a CPU with a speedup of up to 23 times (12 times on average), depending on the scale of the simulation.

What works in family planning interventions: A systematic review of the evidence

PubMed Central

Mwaikambo, Lisa; Speizer, Ilene S.; Schurmann, Anna; Morgan, Gwen; Fikree, Fariyal

2013-01-01

This study presents findings from a systematic review of evaluations of family planning interventions published between 1995 and 2008. Studies that used an experimental or quasi-experimental design or had another way to attribute program exposure to observed changes in fertility or family planning outcomes at the individual or population levels were included and ranked by strength of evidence. A total of 63 studies were found that met the inclusion criteria. The findings from this review are summarized in tabular format by the type of intervention (classified as supply-side or demand-side). About two-thirds of the studies found were on demand generation type-programs. Findings from all programs revealed significant improvements in knowledge, attitudes, discussion, and intentions. Program impacts on contraceptive use and use of family planning services were less consistently found and less than half of the studies that measured fertility or pregnancy-related outcomes found an impact. Based on the review findings, we identify promising programmatic approaches and propose directions for future evaluation research of family planning interventions. PMID:21834409

Crack identification method in beam-like structures using changes in experimentally measured frequencies and Particle Swarm Optimization

NASA Astrophysics Data System (ADS)

Khatir, Samir; Dekemele, Kevin; Loccufier, Mia; Khatir, Tawfiq; Abdel Wahab, Magd

2018-02-01

In this paper, a technique is presented for the detection and localization of an open crack in beam-like structures using experimentally measured natural frequencies and the Particle Swarm Optimization (PSO) method. The technique considers the variation in local flexibility near the crack. The natural frequencies of a cracked beam are determined experimentally and numerically using the Finite Element Method (FEM). The optimization algorithm is programmed in MATLAB. The algorithm is used to estimate the location and severity of a crack by minimizing the differences between measured and calculated frequencies. The method is verified using experimentally measured data on a cantilever steel beam. The Fourier transform is adopted to improve the frequency resolution. The results demonstrate the good accuracy of the proposed technique.

Feasibility study of current pulse induced 2-bit/4-state multilevel programming in phase-change memory

NASA Astrophysics Data System (ADS)

Liu, Yan; Fan, Xi; Chen, Houpeng; Wang, Yueqing; Liu, Bo; Song, Zhitang; Feng, Songlin

2017-08-01

In this brief, multilevel data storage for phase-change memory (PCM) has attracted more attention in the memory market to implement high capacity memory system and reduce cost-per-bit. In this work, we present a universal programing method of SET stair-case current pulse in PCM cells, which can exploit the optimum programing scheme to achieve 2-bit/ 4state resistance-level with equal logarithm interval. SET stair-case waveform can be optimized by TCAD real time simulation to realize multilevel data storage efficiently in an arbitrary phase change material. Experimental results from 1 k-bit PCM test-chip have validated the proposed multilevel programing scheme. This multilevel programming scheme has improved the information storage density, robustness of resistance-level, energy efficient and avoiding process complexity.

Effects of Plyometric and Sprint Training on Physical and Technical Skill Performance in Adolescent Soccer Players.

PubMed

Sáez de Villarreal, Eduardo; Suarez-Arrones, Luis; Requena, Bernardo; Haff, Gregory G; Ferrete, Carlos

2015-07-01

To determine the influence of a short-term combined plyometric and sprint training (9 weeks) within regular soccer practice on explosive and technical actions of pubertal soccer players during the in-season. Twenty-six players were randomly assigned to 2 groups: control group (CG) (soccer training only) and combined group (CombG) (plyometric + acceleration + dribbling + shooting). All players trained soccer 4 times per week and the experimental groups supplemented the soccer training with a proposed plyometric-sprint training program for 40 minutes (2 days per weeks). Ten-meter sprint, 10-m agility with and without ball, CMJ and Abalakov vertical jump, ball-shooting speed, and Yo-Yo intermittent endurance test were measured before and after training. The experimental group followed a 9-week plyometric and sprint program (i.e., jumping, hurdling, bouncing, skipping, and footwork) implemented before the soccer training. Baseline-training results showed no significant differences between the groups in any of the variables tested. No improvement was found in the CG; however, meaningful improvement was found in all variables in the experimental group: CMJ (effect size [ES] = 0.9), Abalakov vertical jump (ES = 1.3), 10-m sprint (ES = 0.7-0.9), 10-m agility (ES = 0.8-1.2), and ball-shooting speed (ES = 0.7-0.8). A specific combined plyometric and sprint training within regular soccer practice improved explosive actions compared with conventional soccer training only. Therefore, the short-term combined program had a beneficial impact on explosive actions, such as sprinting, change of direction, jumping, and ball-shooting speed which are important determinants of match-winning actions in soccer performance. Therefore, we propose modifications to current training methodology for pubertal soccer players to include combined plyometric and speed training for athlete preparation in this sport.

Production of oxygen from lunar soil by molten salt electrolysis

NASA Technical Reports Server (NTRS)

Keller, Rudolf

1989-01-01

A simple approach to utilizing lunar resources proposes to dissolve lunar soil, without or with little beneficiation, in a suitable molten salt and to electrolyze the oxides to oxygen and a metal byproduct. The envisioned process and the required technological advances are discussed. Promising electrolysis conditions have been identified in a recent experimental program to manufacture silicon and aluminum from anorthite.

Using Symmetric Predication of Endogenous Subgroups for Causal Inferences about Program Effects under Robust Assumptions: Part Two of a Method Note in Three Parts

ERIC Educational Resources Information Center

Bell, Stephen H.; Peck, Laura R.

2013-01-01

To answer "what works?" questions about policy interventions based on an experimental design, Peck (2003) proposes to use baseline characteristics to symmetrically divide treatment and control group members into subgroups defined by endogenously determined postrandom assignment events. Symmetric prediction of these subgroups in both…

Block matching sparsity regularization-based image reconstruction for incomplete projection data in computed tomography

NASA Astrophysics Data System (ADS)

Cai, Ailong; Li, Lei; Zheng, Zhizhong; Zhang, Hanming; Wang, Linyuan; Hu, Guoen; Yan, Bin

2018-02-01

In medical imaging many conventional regularization methods, such as total variation or total generalized variation, impose strong prior assumptions which can only account for very limited classes of images. A more reasonable sparse representation frame for images is still badly needed. Visually understandable images contain meaningful patterns, and combinations or collections of these patterns can be utilized to form some sparse and redundant representations which promise to facilitate image reconstructions. In this work, we propose and study block matching sparsity regularization (BMSR) and devise an optimization program using BMSR for computed tomography (CT) image reconstruction for an incomplete projection set. The program is built as a constrained optimization, minimizing the L1-norm of the coefficients of the image in the transformed domain subject to data observation and positivity of the image itself. To solve the program efficiently, a practical method based on the proximal point algorithm is developed and analyzed. In order to accelerate the convergence rate, a practical strategy for tuning the BMSR parameter is proposed and applied. The experimental results for various settings, including real CT scanning, have verified the proposed reconstruction method showing promising capabilities over conventional regularization.

Trans-Pacific HDR Satellite Communications Experiment Phase-2 Project Plan and Experimental Network

NASA Technical Reports Server (NTRS)

Hsu, Eddie; Kadowaki, Naoto; Yoshimura, Naoko; Takahashi, Takashi; Yoshikawa, Makoto; Bergman, Larry; Bhasin, Kul

2000-01-01

The trans-Pacific high data rate (TP-HDR) satellite communications experiment was proposed at the Japan-U.S. Cooperation in Space (JUCS) Program Workshop held in Hawaii in 1993 and remote high definition video post-production was demonstrated as the first phase trial. ATM-based 45 Mbps trans-Pacific link was established in the first phase, and the following experiments with 155 Mbps was planned as the phase 2. This paper describes the experimental network configuration and project plan of TP-HDR experiment phase 2. Additional information is provided in the original.

Designing Pattern Recognition-Based Method for Fast Visual Inspection of the Bucket Wheel Excavator Lattice Structure

NASA Astrophysics Data System (ADS)

Risteiu, M.; Lorincz, A.; Dobra, R.; Dasic, P.; Andras, I.; Roventa, M.

2017-06-01

The proposed paper shows some experimental results of a research in metallic structures inspection by using a high definition camera controller by high processing capabilities. The dedicated ARM Cortex-M4 initializes the ARM Cortex-M0 system for image acquiring. Then, by programming options, we are action for patterns (abnormal situations like metal cracks, or discontinuities) types and tuning, for enabling overexposure highlighting and adjusting camera brightness/exposure, to adjust minimum brightness, and to adjust the pattern’s teach threshold. The proposed system has been tested in normal lighting conditions from the typical site.

Real-time discrete suboptimal control for systems with input and state delays: Experimental tests on a dehydration process.

PubMed

Rodríguez-Guerrero, Liliam; Santos-Sánchez, Omar-Jacobo; Cervantes-Escorcia, Nicolás; Romero, Hugo

2017-11-01

This article presents a suboptimal control strategy with finite horizon for affine nonlinear discrete systems with both state and input delays. The Dynamic Programming Approach is used to obtain the suboptimal control sequence, but in order to avoid the computation of the Bellman functional, a numerical approximation of this function is proposed in every step. The feasibility of our proposal is demonstrated via an experimental test on a dehydration process and the obtained results show a good performance and behavior of this process. Then in order to demonstrate the benefits of using this kind of control strategy, the results are compared with a non optimal control strategy, particularly with respect to results produced by an industrial Proportional Integral Derivative (PID) Honeywell controller, which is tuned using the Ziegler-Nichols method. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

A "Politically Robust" Experimental Design for Public Policy Evaluation, with Application to the Mexican Universal Health Insurance Program

ERIC Educational Resources Information Center

King, Gary; Gakidou, Emmanuela; Ravishankar, Nirmala; Moore, Ryan T.; Lakin, Jason; Vargas, Manett; Tellez-Rojo, Martha Maria; Avila, Juan Eugenio Hernandez; Avila, Mauricio Hernandez; Llamas, Hector Hernandez

2007-01-01

We develop an approach to conducting large-scale randomized public policy experiments intended to be more robust to the political interventions that have ruined some or all parts of many similar previous efforts. Our proposed design is insulated from selection bias in some circumstances even if we lose observations; our inferences can still be…

Participant Satisfaction with a Food Benefit Program with Restrictions and Incentives.

PubMed

Rydell, Sarah A; Turner, Rachael M; Lasswell, Tessa A; French, Simone A; Oakes, J Michael; Elbel, Brian; Harnack, Lisa J

2018-02-01

Policy makers are considering changes to the Supplemental Nutrition Assistance Program (SNAP). Proposed changes include financially incentivizing the purchase of healthier foods and prohibiting the use of funds for purchasing foods high in added sugars. SNAP participant perspectives may be useful in understanding the consequences of these proposed changes. To determine whether food restrictions and/or incentives are acceptable to food benefit program participants. Data were collected as part of an experimental trial in which lower-income adults were randomly assigned to one of four financial food benefit conditions: (1) Incentive: 30% financial incentive on eligible fruits and vegetables purchased using food benefits; (2) Restriction: not allowed to buy sugar-sweetened beverages, sweet baked goods, or candies with food benefits; (3) Incentive plus Restriction; or (4) Control: no incentive/restriction. Participants completed closed- and open-ended questions about their perceptions on completion of the 12-week program. Adults eligible or nearly eligible for SNAP were recruited between 2013 and 2015 by means of events or flyers in the Minneapolis/St Paul, MN, metropolitan area. Of the 279 individuals who completed baseline measures, 265 completed follow-up measures and are included in these analyses. χ 2 analyses were conducted to assess differences in program satisfaction. Responses to open-ended questions were qualitatively analyzed using principles of content analysis. There were no statistically significant or meaningful differences between experimental groups in satisfaction with the program elements evaluated in the study. Most participants in all conditions found the food program helpful in buying nutritious foods (94.1% to 98.5%) and in buying the kinds of foods they wanted (85.9% to 95.6%). Qualitative data suggested that most were supportive of restrictions, although a few were dissatisfied. Participants were uniformly supportive of incentives. Findings suggest a food benefit program that includes incentives for purchasing fruits and vegetables and/or restrictions on the use of program funds for purchasing foods high in added sugars appears to be acceptable to most participants. Copyright © 2018 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Student experiments on Skylab

NASA Technical Reports Server (NTRS)

Floyd, H. B.

1974-01-01

Review of the background and experimental results of the Skylab student project, and assessment of its overall benefits. Virtually all of the objectives of the experiments adopted from student proposals were met. NASA benefited from the program by learning that meaningful experiments could be incorporated into a carry-on or suitcase concept at low cost and within very short time periods. The students benefited greatly from their association with the Skylab program by being afforded a learning opportunity and contact with the real world of research, normally beyond their reach. In addition, hometowns, states, and regions developed a close identification with space exploration.

HIFiRE-5 Flight Vehicle Design

NASA Technical Reports Server (NTRS)

Kimmel, Roger L.; Adamczak, David; Berger, Karen; Choudhari, Meelan

2010-01-01

The Hypersonic International Flight Research Experimentation (HIFiRE) program is a hypersonic flight test program executed by the Air Force Research Laboratories (AFRL) and Australian Defence Science and Technology Organization (DSTO). HIFiRE flight 5 is devoted to measuring transition on a three-dimensional body. This paper summarizes payload configuration, trajectory, vehicle stability limits and roughness tolerances. Results show that the proposed configuration is suitable for testing transition on a three-dimensional body. Transition is predicted to occur within the test window, and a design has been developed that will allow the vehicle to be manufactured within prescribed roughness tolerances

Genetic programming for evolving due-date assignment models in job shop environments.

PubMed

Nguyen, Su; Zhang, Mengjie; Johnston, Mark; Tan, Kay Chen

2014-01-01

Due-date assignment plays an important role in scheduling systems and strongly influences the delivery performance of job shops. Because of the stochastic and dynamic nature of job shops, the development of general due-date assignment models (DDAMs) is complicated. In this study, two genetic programming (GP) methods are proposed to evolve DDAMs for job shop environments. The experimental results show that the evolved DDAMs can make more accurate estimates than other existing dynamic DDAMs with promising reusability. In addition, the evolved operation-based DDAMs show better performance than the evolved DDAMs employing aggregate information of jobs and machines.

Maternal employment and the health of low-income young children.

PubMed

Gennetian, Lisa A; Hill, Heather D; London, Andrew S; Lopoo, Leonard M

2010-05-01

This study examines whether maternal employment affects the health status of low-income, elementary-school-aged children using instrumental variables estimation and experimental data from a welfare-to-work program implemented in the early 1990s. Maternal report of child health status is predicted as a function of exogenous variation in maternal employment associated with random assignment to the experimental group. IV estimates show a modest adverse effect of maternal employment on children's health. Making use of data from another welfare-to-work program we propose that any adverse effect on child health may be tempered by increased family income and access to public health insurance coverage, findings with direct relevance to a number of current policy discussions. In a secondary analysis using fixed effects techniques on longitudinal survey data collected in 1998 and 2001, we find a comparable adverse effect of maternal employment on child health that supports the external validity of our primary result.

Intervention strategies for spatial orientation disorders in dementia: a selective review.

PubMed

Caffò, Alessandro O; Hoogeveen, Frans; Groenendaal, Mari; Perilli, Anna Viviana; Picucci, Luciana; Lancioni, Giulio E; Bosco, Andrea

2014-06-01

This article provides a brief overview of the intervention strategies aimed at reducing spatial orientation disorders in elderly people with dementia. Eight experimental studies using spatial cues, assistive technology programs, reality orientation training, errorless learning technique, and backward chaining programs are described. They can be classified into two main approaches: restorative and compensatory, depending on whether they rely or not on residual learning ability, respectively. A review of the efficacy of these intervention strategies is proposed. Results suggest that both compensatory and restorative approaches may be valuable in enhancing correct way-finding behavior, with various degrees of effectiveness. Some issues concerning (a) variability in participants' characteristics and experimental designs and (b) practicality of intervention strategies do not permit to draw a definite conclusion. Future research should be aimed at a direct comparison between these two strategies, and should incorporate an extensive neuropsychological assessment of spatial domain.

Novel Bio, Chemical, Environmental Sensing Based on New Model of Total Internal Reflection in Turbid Media

NASA Astrophysics Data System (ADS)

Bali, Samir; Judge, Patrick; Phillip, Nathan; Boivin, Jordan; Scaffidi, Jonathan; Berberich, Jason; Bali, Lalit

2014-05-01

We have initiated a collaborative experimental research program that combines new advances in optical physics, field portable chemical analysis, and biosensing. Our goal is to discover and characterize new optical sensing methodologies in opaque, highly scattering (i.e., ``turbid'') media, and demonstrate new paradigms for optical sensing in research and industry. We have three specific objectives. First, we propose to fully characterize and validate a new model of total internal reflection (TIR) from highly turbid media thus enabling a first demonstration of non-invasive, in-situ, real-time particle sizing for the case of arbitrary scattering particle size-a holy grail in colloidal science. Second, we propose to implement a first demonstration of real-time non-invasive measurement of nanoparticle aggregation in highly turbid media. Third, we propose to use our new sensing methodology to demonstrate real-time in-situ label-free monitoring of molecular interactions and adsorption at surfaces. We gratefully acknowledge support from the American Chemical Society Petroleum Research Fund and Miami University's Interdisciplinary Roundtable Fund. We also gratefully acknowledge experimental help from the Miami University Instrumentation Laboratory.

Study protocol: incentives for increased access to comprehensive family planning for urban youth using a benefits card in Uganda. A quasi-experimental study.

PubMed

Nuwasiima, Afra; Nuwamanya, Elly; Navvuga, Patricia; Babigumira, Janet U; Asiimwe, Francis T; Lubinga, Solomon J; Babigumira, Joseph B

2017-10-27

The use of contraception is one of the most cost-effective public health interventions and has the potential to prevent about 30% of maternal and 10% of child deaths in developing countries. Voucher-based initiatives for family planning are an effective and viable means of increasing contraceptive use. In this paper, we present a protocol for a pilot study of a novel incentive, a family planning benefits card (FPBC) program to increase uptake of family planning services among urban poor youth in Uganda while leveraging private sector funding. The study employs both impact and health economic evaluation methods to assess the effect of the FPBC program. We propose a quasi-experimental study design with two separate pre- and post-samples to measure program effectiveness. The main outcome of the impact evaluation is the percentage change in the prevalence of modern contraceptive use and unmet need for contraception. We will also conduct model-based incremental cost-effectiveness and budget impact analyses. The main outcomes of the economic evaluation are the cost per enrolled youth and cost per pregnancy averted, and cost per disability-adjusted life-year (DALY) averted. We will also pilot a corporate social responsibility model of sponsorship for the FPBC program in partnership with local corporations. Budget impact analysis will examine the potential affordability of scaling up the FPBC program and the fiscal implications of this scale up to the corporate social responsibility (CSR) budgets of partner corporations, the government, and the individual taxpayer. In this study, we propose an impact and economic evaluation to establish the proof concept of using a FPBC program to increase uptake of family planning services among urban poor youth in Uganda. The results of this study will present stakeholders in Uganda and internationally with a potentially viable option for corporate-sponsored access to family planning in urban poor communities. MUREC1/7 No. 10/05-17. Registered 19th July 2017.

An Extended Damage Plasticity Model for Shotcrete: Formulation and Comparison with Other Shotcrete Models

PubMed Central

Neuner, Matthias; Gamnitzer, Peter; Hofstetter, Günter

2017-01-01

The aims of the present paper are (i) to briefly review single-field and multi-field shotcrete models proposed in the literature; (ii) to propose the extension of a damage-plasticity model for concrete to shotcrete; and (iii) to evaluate the capabilities of the proposed extended damage-plasticity model for shotcrete by comparing the predicted response with experimental data for shotcrete and with the response predicted by shotcrete models, available in the literature. The results of the evaluation will be used for recommendations concerning the application and further improvements of the investigated shotcrete models and they will serve as a basis for the design of a new lab test program, complementing the existing ones. PMID:28772445

Lightweight two-stroke cycle aircraft diesel engine technology enablement program, volume 1

NASA Technical Reports Server (NTRS)

Freen, P. D.; Berenyi, S. G.; Brouwers, A. P.; Moynihan, M. E.

1985-01-01

An experimental Single Cylinder Test Engine Program is conducted to confirm the analytically projected performance of a two-stroke cycle diesel engine for aircraft applications. The test engine delivered 78kW indicated power from 1007cc displacement, operating at 3500 RPM on Schnuerle loop scavenged two-stroke cycle. Testing confirms the ability of a proposed 4-cylinder version of such an engine to reach the target power at altitude, in a highly turbocharged configuration. The experimental program defines all necessary parameters to permit design of a multicylinder engine for eventual flight applications; including injection system requirement, turbocharging, heat rejection, breathing, scavenging, and structural requirements. The multicylinder engine concept is configured to operate with an augmented turbocharger, but with no primary scavenge blower. The test program is oriented to provide a balanced turbocharger compressor to turbine power balance without an auxiliary scavenging system. Engine cylinder heat rejection to the ambient air has been significantly reduced and the minimum overall turbocharger efficiency required is within the range of commercially available turbochargers. Analytical studies and finite element modeling is made of insulated configurations of the engines - including both ceramic and metallic versions. A second generation test engine is designed based on current test results.

Low-rank regularization for learning gene expression programs.

PubMed

Ye, Guibo; Tang, Mengfan; Cai, Jian-Feng; Nie, Qing; Xie, Xiaohui

2013-01-01

Learning gene expression programs directly from a set of observations is challenging due to the complexity of gene regulation, high noise of experimental measurements, and insufficient number of experimental measurements. Imposing additional constraints with strong and biologically motivated regularizations is critical in developing reliable and effective algorithms for inferring gene expression programs. Here we propose a new form of regulation that constrains the number of independent connectivity patterns between regulators and targets, motivated by the modular design of gene regulatory programs and the belief that the total number of independent regulatory modules should be small. We formulate a multi-target linear regression framework to incorporate this type of regulation, in which the number of independent connectivity patterns is expressed as the rank of the connectivity matrix between regulators and targets. We then generalize the linear framework to nonlinear cases, and prove that the generalized low-rank regularization model is still convex. Efficient algorithms are derived to solve both the linear and nonlinear low-rank regularized problems. Finally, we test the algorithms on three gene expression datasets, and show that the low-rank regularization improves the accuracy of gene expression prediction in these three datasets.

Landmark matching based retinal image alignment by enforcing sparsity in correspondence matrix.

PubMed

Zheng, Yuanjie; Daniel, Ebenezer; Hunter, Allan A; Xiao, Rui; Gao, Jianbin; Li, Hongsheng; Maguire, Maureen G; Brainard, David H; Gee, James C

2014-08-01

Retinal image alignment is fundamental to many applications in diagnosis of eye diseases. In this paper, we address the problem of landmark matching based retinal image alignment. We propose a novel landmark matching formulation by enforcing sparsity in the correspondence matrix and offer its solutions based on linear programming. The proposed formulation not only enables a joint estimation of the landmark correspondences and a predefined transformation model but also combines the benefits of the softassign strategy (Chui and Rangarajan, 2003) and the combinatorial optimization of linear programming. We also introduced a set of reinforced self-similarities descriptors which can better characterize local photometric and geometric properties of the retinal image. Theoretical analysis and experimental results with both fundus color images and angiogram images show the superior performances of our algorithms to several state-of-the-art techniques. Copyright © 2013 Elsevier B.V. All rights reserved.

Clustering of the human skeletal muscle fibers using linear programming and angular Hilbertian metrics.

PubMed

Neji, Radhouène; Besbes, Ahmed; Komodakis, Nikos; Deux, Jean-François; Maatouk, Mezri; Rahmouni, Alain; Bassez, Guillaume; Fleury, Gilles; Paragios, Nikos

2009-01-01

In this paper, we present a manifold clustering method fo the classification of fibers obtained from diffusion tensor images (DTI) of the human skeletal muscle. Using a linear programming formulation of prototype-based clustering, we propose a novel fiber classification algorithm over manifolds that circumvents the necessity to embed the data in low dimensional spaces and determines automatically the number of clusters. Furthermore, we propose the use of angular Hilbertian metrics between multivariate normal distributions to define a family of distances between tensors that we generalize to fibers. These metrics are used to approximate the geodesic distances over the fiber manifold. We also discuss the case where only geodesic distances to a reduced set of landmark fibers are available. The experimental validation of the method is done using a manually annotated significant dataset of DTI of the calf muscle for healthy and diseased subjects.

Stability limits and dynamics of nonaxisymmetric liquid bridges

NASA Technical Reports Server (NTRS)

Alexander, J. Iwan D.; Resnik, Andy; Kaukler, William F.

1993-01-01

This program of theoretical and experimental ground-based and low gravity research is focussed on the understanding of the dynamics and stability limits of nonaxisymmetric liquid bridges. There are three basic objectives to the proposed work: (1) to determine the stability limits of nonaxisymmetric liquid bridges held between non-coaxially aligned disks; (2) to examine the dynamics of nonaxisymmetric bridges and nonaxisymmetric oscillations of initially axisymmetric bridges (some of these experiments require a low gravity environment and the ground-based research will culminate in a definitive flight experiment); and (3) to experimentally investigate the vibration sensitivity of liquid bridges under terrestrial and low gravity conditions.

Reliability of Next Generation Power Electronics Packaging Under Concurrent Vibration, Thermal and High Power Loads

DTIC Science & Technology

2008-02-01

combined thermal g effect and initial current field. The model is implemented using Abaqus user element subroutine and verified against the experimental...Finite Element Formulation The proposed model is implemented with ABAQUS general purpose finite element program using thermal -displacement analysis...option. ABAQUS and other commercially available finite element codes do not have the capability to solve general electromigration problem directly. Thermal

A Preliminary Investigation of Hall Thruster Technology

NASA Technical Reports Server (NTRS)

Gallimore, Alec D.

1997-01-01

A three-year NASA/BMDO-sponsored experimental program to conduct performance and plume plasma property measurements on two Russian Stationary Plasma Thrusters (SPTs) has been completed. The program utilized experimental facilitates at the University of Michigan's Plasmadynamics and Electric Propulsion Laboratory (PEPL). The main features of the proposed effort were as follows: (1) Characterized Hall thruster (and arcjet) performance by measuring ion exhaust velocity with probes at various thruster conditions; (2) Used a variety of probe diagnostics in the thruster plume to measure plasma properties and flow properties including T(sub e) and n(sub e) ion current density and ion energy distribution, and electric fields by mapping plasma potential; (3) Used emission spectroscopy to identify species within the plume and to measure electron temperatures. A key and unique feature of our research was our collaboration with Russian Hall thruster researcher Dr. Sergey A Khartov, Deputy Dean of International Relations at the Moscow Aviation Institute (MAI). His activities in this program included consulting on and participation in research at PEPL through use of a MAI-built SPT and ion energy probe.

Statistical Symbolic Execution with Informed Sampling

NASA Technical Reports Server (NTRS)

Filieri, Antonio; Pasareanu, Corina S.; Visser, Willem; Geldenhuys, Jaco

2014-01-01

Symbolic execution techniques have been proposed recently for the probabilistic analysis of programs. These techniques seek to quantify the likelihood of reaching program events of interest, e.g., assert violations. They have many promising applications but have scalability issues due to high computational demand. To address this challenge, we propose a statistical symbolic execution technique that performs Monte Carlo sampling of the symbolic program paths and uses the obtained information for Bayesian estimation and hypothesis testing with respect to the probability of reaching the target events. To speed up the convergence of the statistical analysis, we propose Informed Sampling, an iterative symbolic execution that first explores the paths that have high statistical significance, prunes them from the state space and guides the execution towards less likely paths. The technique combines Bayesian estimation with a partial exact analysis for the pruned paths leading to provably improved convergence of the statistical analysis. We have implemented statistical symbolic execution with in- formed sampling in the Symbolic PathFinder tool. We show experimentally that the informed sampling obtains more precise results and converges faster than a purely statistical analysis and may also be more efficient than an exact symbolic analysis. When the latter does not terminate symbolic execution with informed sampling can give meaningful results under the same time and memory limits.

Logic integer programming models for signaling networks.

PubMed

Haus, Utz-Uwe; Niermann, Kathrin; Truemper, Klaus; Weismantel, Robert

2009-05-01

We propose a static and a dynamic approach to model biological signaling networks, and show how each can be used to answer relevant biological questions. For this, we use the two different mathematical tools of Propositional Logic and Integer Programming. The power of discrete mathematics for handling qualitative as well as quantitative data has so far not been exploited in molecular biology, which is mostly driven by experimental research, relying on first-order or statistical models. The arising logic statements and integer programs are analyzed and can be solved with standard software. For a restricted class of problems the logic models reduce to a polynomial-time solvable satisfiability algorithm. Additionally, a more dynamic model enables enumeration of possible time resolutions in poly-logarithmic time. Computational experiments are included.

Analysis and design of insulation systems for LH2-fueled aircraft

NASA Technical Reports Server (NTRS)

Cunnington, G. R., Jr.

1979-01-01

An analytical program was conducted to evaluate the performance of 15 potential insulations for the fuel tanks of a subsonic LH2-fueled transport aircraft intended for airline service in the 1990-1995 time period. As a result, two candidate insulation systems are proposed for subsonic transport aircraft applications. Both candidates are judged to be the optimum available and should meet the design requirements. However, because of the long-life cyclic nature of the application and the cost sensitivity of airline operations, an experimental tank/insulation development or proof-of-concept program is recommended. This program should be carried out with a nearly full-scale system which would be subjected to the cyclic thermal and mechanical inputs anticipated in aircraft service.

Long-term Impact of Prevention Programs to Promote Effective Parenting: Lasting Effects but Uncertain Processes

PubMed Central

Sandler, Irwin; Schoenfelder, Erin; Wolchik, Sharlene; MacKinnon, David

2010-01-01

This chapter reviews findings from 46 randomized experimental trials of preventive parenting interventions. The findings of these trials provide evidence of effects to prevent a wide range of problem outcomes and to promote competencies from one to twenty years later. However, there is a paucity of evidence concerning the processes that account for program effects. Three alternative pathways are proposed as a framework for future research on the long-term effects of preventive parenting programs; 1) through program effects on parenting skills, perceptions of parental efficacy and reduction in barriers to effective parenting; 2) through program-induced reductions in short-term problems of youth that persist over time, improvements in youth adaptation to stress, and improvements in youth belief systems concerning the self and their relationships with others; and 3) through effects on contexts in which youth become involved and on youth-environment transactions. PMID:20822438

A proposed non-intrusive method for finding coefficients of slip and molecular reflectivity in microgravity

NASA Technical Reports Server (NTRS)

Noever, D. A.; Rosenberger, F. E.

1989-01-01

A proposed experimental program to look at a series of vapor transport properties measured along solid and liquid surfaces is described. The research objectives proposed are: (1) with accuracy otherwise unobtainable on ground, to determine the coefficient of slip measured between gases and the surfaces of liquids and solids; (2) for the first time, to classify and tabulate dominant surface effects found for a variety of solids, particularly those crystalized by vapor transport; and (3) to extend understanding of settling rates predicted for cosmic dust and condensed vapor falling through planetary atmospheres. The method used to obtain these objectives, has aided, to an order of magnitude, understanding of various liquid-gas interfaces such as oil and water. But to date, no similar characterization has proved successful for solids or liquids of uncertain densities. Likewise, no data exist in either ground-based research or as part of a microgravity program that, when collected with the high accuracy expected in low gravity, could definitely settle outstanding questions in kinetic theory, molecular dynamics, and cosmic physics.

Appraisal of potential for injection-well recharge of the Hueco bolson with treated sewage effluent : preliminary study at the northeast El Paso area, Texas

USGS Publications Warehouse

Garza, Sergio; Weeks, Edwin P.; White, Donald E.

1980-01-01

The proposed injection water will require strict water-quality controls, which may involve chlorination and the removal of suspended solids. Mixing of the proposed injection water with the native ground water probably will not clog the aquifer by mineral precipitation. The relatively large concentrations of sodium in the injection water may reduce the hydraulic conductivity of the clay layers in the aquifer, but the permeable sands should not be seriously affected. Plans for an artificial-recharge program need to include an experimental installation to evaluate the system under field conditions.

Dry deposition models for radionuclides dispersed in air: a new approach for deposition velocity evaluation schema

NASA Astrophysics Data System (ADS)

Giardina, M.; Buffa, P.; Cervone, A.; De Rosa, F.; Lombardo, C.; Casamirra, M.

2017-11-01

In the framework of a National Research Program funded by the Italian Minister of Economic Development, the Department of Energy, Information Engineering and Mathematical Models (DEIM) of Palermo University and ENEA Research Centre of Bologna, Italy are performing several research activities to study physical models and mathematical approaches aimed at investigating dry deposition mechanisms of radioactive pollutants. On the basis of such studies, a new approach to evaluate the dry deposition velocity for particles is proposed. Comparisons with some literature experimental data show that the proposed dry deposition scheme can capture the main phenomena involved in the dry deposition process successfully.

AISLE: an automatic volumetric segmentation method for the study of lung allometry.

PubMed

Ren, Hongliang; Kazanzides, Peter

2011-01-01

We developed a fully automatic segmentation method for volumetric CT (computer tomography) datasets to support construction of a statistical atlas for the study of allometric laws of the lung. The proposed segmentation method, AISLE (Automated ITK-Snap based on Level-set), is based on the level-set implementation from an existing semi-automatic segmentation program, ITK-Snap. AISLE can segment the lung field without human interaction and provide intermediate graphical results as desired. The preliminary experimental results show that the proposed method can achieve accurate segmentation, in terms of volumetric overlap metric, by comparing with the ground-truth segmentation performed by a radiologist.

Elevated temperature crack growth

NASA Technical Reports Server (NTRS)

Yau, J. F.; Malik, S. N.; Kim, K. S.; Vanstone, R. H.; Laflen, J. H.

1985-01-01

The objective of the Elevated Temperature Crack Growth Project is to evaluate proposed nonlinear fracture mechanics methods for application to combustor liners of aircraft gas turbine engines. During the first year of this program, proposed path-independent (P-I) integrals were reviewed for such applications. Several P-I integrals were implemented into a finite-element postprocessor which was developed and verified as part of the work. Alloy 718 was selected as the analog material for use in the forthcoming experimental work. A buttonhead, single-edge notch specimen was designed and verified for use in elevated-temperature strain control testing with significant inelastic strains. A crack mouth opening displacement measurement device was developed for further use.

Teaching learning algorithm based optimization of kerf deviations in pulsed Nd:YAG laser cutting of Kevlar-29 composite laminates

NASA Astrophysics Data System (ADS)

Gautam, Girish Dutt; Pandey, Arun Kumar

2018-03-01

Kevlar is the most popular aramid fiber and most commonly used in different technologically advanced industries for various applications. But the precise cutting of Kevlar composite laminates is a difficult task. The conventional cutting methods face various defects such as delamination, burr formation, fiber pullout with poor surface quality and their mechanical performance is greatly affected by these defects. The laser beam machining may be an alternative of the conventional cutting processes due to its non-contact nature, requirement of low specific energy with higher production rate. But this process also faces some problems that may be minimized by operating the machine at optimum parameters levels. This research paper examines the effective utilization of the Nd:YAG laser cutting system on difficult-to-cut Kevlar-29 composite laminates. The objective of the proposed work is to find the optimum process parameters settings for getting the minimum kerf deviations at both sides. The experiments have been conducted on Kevlar-29 composite laminates having thickness 1.25 mm by using Box-Benkhen design with two center points. The experimental data have been used for the optimization by using the proposed methodology. For the optimization, Teaching learning Algorithm based approach has been employed to obtain the minimum kerf deviation at bottom and top sides. A self coded Matlab program has been developed by using the proposed methodology and this program has been used for the optimization. Finally, the confirmation tests have been performed to compare the experimental and optimum results obtained by the proposed methodology. The comparison results show that the machining performance in the laser beam cutting process has been remarkably improved through proposed approach. Finally, the influence of different laser cutting parameters such as lamp current, pulse frequency, pulse width, compressed air pressure and cutting speed on top kerf deviation and bottom kerf deviation during the Nd:YAG laser cutting of Kevlar-29 laminates have been discussed.

The implementation and use of ADA on distributed systems with high reliability requirements

NASA Technical Reports Server (NTRS)

Knight, J. C.

1985-01-01

The use and implementation of Ada in distributed environments in which reliability is the primary concern is investigated. Emphasis is placed on the possibility that a distributed system may be programmed entirely in Ada so that the individual tasks of the system are unconcerned with which processors they are executing on, and that failures may occur in the software or underlying hardware. A new linguistic construct, the colloquy, is introduced which solves the problems identified in an earlier proposal, the conversation. It was shown that the colloquy is at least as powerful as recovery blocks, but it is also as powerful as all the other language facilities proposed for other situations requiring backward error recovery: recovery blocks, deadlines, generalized exception handlers, traditional conversations, s-conversations, and exchanges. The major features that distinguish the colloquy are described. Sample programs that were written, but not executed, using the colloquy show that extensive backward error recovery can be included in these programs simply and elegantly. These ideas are being implemented in an experimental Ada test bed.

Regulation Effects by Programmed Molecules for Transcription-Based Diagnostic Automata towards Therapeutic Use

NASA Astrophysics Data System (ADS)

Hirabayashi, Miki; Ohashi, Hirotada; Kubo, Tai

We have presented experimental analysis on the controllability of our transcription-based diagnostic biomolecular automata by programmed molecules. Focusing on the noninvasive transcriptome diagnosis by salivary mRNAs, we already proposed the novel concept of diagnostic device using DNA computation. This system consists of the main computational element which has a stem shaped promoter region and a pseudo-loop shaped read-only memory region for transcription regulation through the conformation change caused by the recognition of disease-related biomarkers. We utilize the transcription of malachite green aptamer sequence triggered by the target recognition for observation of detection. This algorithm makes it possible to release RNA-aptamer drugs multiply, different from the digestion-based systems by the restriction enzyme which was proposed previously, for the in-vivo use, however, the controllability of aptamer release is not enough at the previous stage. In this paper, we verified the regulation effect on aptamer transcription by programmed molecules in basic conditions towards the developm! ent of therapeutic automata. These results would bring us one step closer to the realization of new intelligent diagnostic and therapeutic automata based on molecular circuits.

Final construction and testing of an experimental sprinkler/groundwater treatment system for proposed use by the village of Utica, Nebraska.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2005-06-17

The testing described above demonstrates that the experimental sprinkler designed by Argonne could be successfully, and safely, used by the Village of Utica for irrigation of the town's playing fields, using contaminated (by carbon tetrachloride) groundwater from the shallow aquifer beneath the town. Routine operation of the sprinkler within the range of parameters identified by the testing program would effectively reduce carbon tetrachloride concentrations in the discharged spray reaching the ground to levels below the MCL (5 {micro}g/l). CCC/USDA and Argonne propose to test use of the experimental sprinkler by the Village of Utica during the next (Summer 2001) growingmore » season, under Argonne supervision. Water will be supplied from the well to the sprinkler drive unit using a temporary, flexible (high-pressure hose) connection. Argonne will provide training to Village staff in the setup and use of the sprinkler, and will conduct periodic monitoring (proposed biweekly, initially) of the watering operations and sampling and analysis of the spray discharge from the unit, to ensure that the specified groundwater cleanup performance of the sprinkler system (to carbon tetrachloride values <5 {micro}g/L) is maintained. If testing of the sprinkler in this manner proves successful during 2001, CCC/USDA will seek to permanently transfer ownership and operation responsibilities for the sprinkler to the Utica Village Board.« less

Behavioral biometrics for verification and recognition of malicious software agents

NASA Astrophysics Data System (ADS)

Yampolskiy, Roman V.; Govindaraju, Venu

2008-04-01

Homeland security requires technologies capable of positive and reliable identification of humans for law enforcement, government, and commercial applications. As artificially intelligent agents improve in their abilities and become a part of our everyday life, the possibility of using such programs for undermining homeland security increases. Virtual assistants, shopping bots, and game playing programs are used daily by millions of people. We propose applying statistical behavior modeling techniques developed by us for recognition of humans to the identification and verification of intelligent and potentially malicious software agents. Our experimental results demonstrate feasibility of such methods for both artificial agent verification and even for recognition purposes.

An intelligent subtitle detection model for locating television commercials.

PubMed

Huang, Yo-Ping; Hsu, Liang-Wei; Sandnes, Frode-Eika

2007-04-01

A strategy for locating television (TV) commercials in TV programs is proposed. Based on the observation that most TV commercials do not have subtitles, the first stage exploits six subtitle constraints and an adaptive neurofuzzy inference system model to determine whether a frame contains a subtitle or not. The second stage involves locating the mark-in/mark-out points using a genetic algorithm. An interactive user interface allows users to efficiently identify and fine-tune the exact boundaries separating the commercials from the program content. Furthermore, erroneous boundaries are manually corrected. Experimental results show that the precision rate and recall rates exceed 90%.

Permutation tests for goodness-of-fit testing of mathematical models to experimental data.

PubMed

Fişek, M Hamit; Barlas, Zeynep

2013-03-01

This paper presents statistical procedures for improving the goodness-of-fit testing of theoretical models to data obtained from laboratory experiments. We use an experimental study in the expectation states research tradition which has been carried out in the "standardized experimental situation" associated with the program to illustrate the application of our procedures. We briefly review the expectation states research program and the fundamentals of resampling statistics as we develop our procedures in the resampling context. The first procedure we develop is a modification of the chi-square test which has been the primary statistical tool for assessing goodness of fit in the EST research program, but has problems associated with its use. We discuss these problems and suggest a procedure to overcome them. The second procedure we present, the "Average Absolute Deviation" test, is a new test and is proposed as an alternative to the chi square test, as being simpler and more informative. The third and fourth procedures are permutation versions of Jonckheere's test for ordered alternatives, and Kendall's tau(b), a rank order correlation coefficient. The fifth procedure is a new rank order goodness-of-fit test, which we call the "Deviation from Ideal Ranking" index, which we believe may be more useful than other rank order tests for assessing goodness-of-fit of models to experimental data. The application of these procedures to the sample data is illustrated in detail. We then present another laboratory study from an experimental paradigm different from the expectation states paradigm - the "network exchange" paradigm, and describe how our procedures may be applied to this data set. Copyright © 2012 Elsevier Inc. All rights reserved.

A systemic approach for modeling biological evolution using Parallel DEVS.

PubMed

Heredia, Daniel; Sanz, Victorino; Urquia, Alfonso; Sandín, Máximo

2015-08-01

A new model for studying the evolution of living organisms is proposed in this manuscript. The proposed model is based on a non-neodarwinian systemic approach. The model is focused on considering several controversies and open discussions about modern evolutionary biology. Additionally, a simplification of the proposed model, named EvoDEVS, has been mathematically described using the Parallel DEVS formalism and implemented as a computer program using the DEVSLib Modelica library. EvoDEVS serves as an experimental platform to study different conditions and scenarios by means of computer simulations. Two preliminary case studies are presented to illustrate the behavior of the model and validate its results. EvoDEVS is freely available at http://www.euclides.dia.uned.es. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Short-term Power Load Forecasting Based on Balanced KNN

NASA Astrophysics Data System (ADS)

Lv, Xianlong; Cheng, Xingong; YanShuang; Tang, Yan-mei

2018-03-01

To improve the accuracy of load forecasting, a short-term load forecasting model based on balanced KNN algorithm is proposed; According to the load characteristics, the historical data of massive power load are divided into scenes by the K-means algorithm; In view of unbalanced load scenes, the balanced KNN algorithm is proposed to classify the scene accurately; The local weighted linear regression algorithm is used to fitting and predict the load; Adopting the Apache Hadoop programming framework of cloud computing, the proposed algorithm model is parallelized and improved to enhance its ability of dealing with massive and high-dimension data. The analysis of the household electricity consumption data for a residential district is done by 23-nodes cloud computing cluster, and experimental results show that the load forecasting accuracy and execution time by the proposed model are the better than those of traditional forecasting algorithm.

Verification of Accelerated Testing Methodology for Long-Term Durability of CFRP Laminates for Marine Use

DTIC Science & Technology

2012-01-30

CFRP LAMINATES FOR MARINE USE Sa. CONTRACT NUMBER 5b. GRANT NUMBER N00014-06-1-1139 Sc. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Miyano, Yasushi...prediction of CFRP laminates proposed and confirmed experimentally in the previous ONR project of Grant # N000140110949 was verified theoretically and refined...DURABILITY OF CFRP LAMINATES FOR MARINE USE Principal Investigator Yasushi Miyano Co-principal Investigator Isao Kimpara Materials System

THE ARMOUR DUST FUELED REACTOR (ADFR)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krucoff, D.

1958-01-01

The A-DFR is based on the use of a fissionable dust carried in a gas. This fuel ferm offers promise of a major economic advance through the use of 2,000 to 3,000 F operating temperatures and a low cost fuel cycle. The development program is described that was initiated to investigate experimentally the proposed fuel and study analytically other reactor characteristics. A brief review of the reactor concept is presented. (W.D.M.)

From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data.

PubMed

Bottini, Silvia; Hamouda-Tekaya, Nedra; Tanasa, Bogdan; Zaragosi, Laure-Emmanuelle; Grandjean, Valerie; Repetto, Emanuela; Trabucchi, Michele

2017-05-19

Experimental evidence indicates that about 60% of miRNA-binding activity does not follow the canonical rule about the seed matching between miRNA and target mRNAs, but rather a non-canonical miRNA targeting activity outside the seed or with a seed-like motifs. Here, we propose a new unbiased method to identify canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked ImmunoPrecipitation associated to high-throughput sequencing (CLIP-seq). Since the quality of peaks is of pivotal importance for the final output of the proposed method, we provide a comprehensive benchmarking of four peak detection programs, namely CIMS, PIPE-CLIP, Piranha and Pyicoclip, on four publicly available Ago2-HITS-CLIP datasets and one unpublished in-house Ago2-dataset in stem cells. We measured the sensitivity, the specificity and the position accuracy toward miRNA binding sites identification, and the agreement with TargetScan. Secondly, we developed a new pipeline, called miRBShunter, to identify canonical and non-canonical miRNA-binding sites based on de novo motif identification from Ago2 peaks and prediction of miRNA::RNA heteroduplexes. miRBShunter was tested and experimentally validated on the in-house Ago2-dataset and on an Ago2-PAR-CLIP dataset in human stem cells. Overall, we provide guidelines to choose a suitable peak detection program and a new method for miRNA-target identification. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data

PubMed Central

Bottini, Silvia; Hamouda-Tekaya, Nedra; Tanasa, Bogdan; Zaragosi, Laure-Emmanuelle; Grandjean, Valerie; Repetto, Emanuela

2017-01-01

Abstract Experimental evidence indicates that about 60% of miRNA-binding activity does not follow the canonical rule about the seed matching between miRNA and target mRNAs, but rather a non-canonical miRNA targeting activity outside the seed or with a seed-like motifs. Here, we propose a new unbiased method to identify canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked ImmunoPrecipitation associated to high-throughput sequencing (CLIP-seq). Since the quality of peaks is of pivotal importance for the final output of the proposed method, we provide a comprehensive benchmarking of four peak detection programs, namely CIMS, PIPE-CLIP, Piranha and Pyicoclip, on four publicly available Ago2-HITS-CLIP datasets and one unpublished in-house Ago2-dataset in stem cells. We measured the sensitivity, the specificity and the position accuracy toward miRNA binding sites identification, and the agreement with TargetScan. Secondly, we developed a new pipeline, called miRBShunter, to identify canonical and non-canonical miRNA-binding sites based on de novo motif identification from Ago2 peaks and prediction of miRNA::RNA heteroduplexes. miRBShunter was tested and experimentally validated on the in-house Ago2-dataset and on an Ago2-PAR-CLIP dataset in human stem cells. Overall, we provide guidelines to choose a suitable peak detection program and a new method for miRNA-target identification. PMID:28108660

The effect of a program to promote play to reduce children's post-surgical pain: with plush toys, it hurts less.

PubMed

Ullán, Ana M; Belver, Manuel H; Fernández, Esperanza; Lorente, Felix; Badía, Marta; Fernández, Beatriz

2014-03-01

Various nonpharmacological strategies to relieve hospitalized children's pain propose play as a central element. Play is considered an essential resource to improve the negative psychosocial effects of the disease and the hospitalization itself. However, the empirical research of play in health settings has not received much attention. The goal of this study was to determine the effect of a program to promote play in the hospital on postsurgical pain in pediatric patients. The research hypothesis was that children will manifest less pain if they are distracted through play during the postsurgical period. We carried out a randomized parallel trial with two groups, an experimental group and a control group. The control group did not receive any specific treatment, only the standard attention contemplated in the hospital. The parents of the children from the experimental group received instructions to play with their children in the postsurgical period and specific play material with which to play. The results obtained support the research hypothesis. On average, the children from the experimental group scored lower on a pain scale than the children from the control group. This occurred in the three postsurgical measurements of pain. It is concluded that the program to promote play can decrease children's perception of pain. Copyright © 2014 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.

Thermo-osmosis in Membrane Systems: A Review

NASA Astrophysics Data System (ADS)

Barragán, V. María; Kjelstrup, Signe

2017-06-01

We give a first review of experimental results for a phenomenon little explored in the literature, namely thermal osmosis or thermo-osmosis. Such systems are now getting increased attention because of their ability to use waste heat for separation purposes. We show that this volume transport of a solution or a pure liquid caused by a temperature difference across a membrane can be understood as a property of the membrane system, i. e. the membrane with its adjacent solutions. We present experimental values found in the literature of thermo-osmotic coefficients of neutral and hydrophobic as well as charged and hydrophilic membranes, with water and other permeant fluids as well as electrolyte solutions. We propose that the coefficient can be qualitatively explained by a formula that contains the entropy of adsorption of permeant into the membrane, the hydraulic permeability, and a factor that depends on the interface resistance to heat transfer. A variation in the entropy of adsorption with hydrophobic/hydrophilic membranes and structure breaking/structure making cations could then explain the sign of the permeant flux. Systematic experiments in the field are lacking and we propose an experimental program to mend this situation.

The spectral positioning algorithm of new spectrum vehicle based on convex programming in wireless sensor network

NASA Astrophysics Data System (ADS)

Zhang, Yongjun; Lu, Zhixin

2017-10-01

Spectrum resources are very precious, so it is increasingly important to locate interference signals rapidly. Convex programming algorithms in wireless sensor networks are often used as localization algorithms. But in view of the traditional convex programming algorithm is too much overlap of wireless sensor nodes that bring low positioning accuracy, the paper proposed a new algorithm. Which is mainly based on the traditional convex programming algorithm, the spectrum car sends unmanned aerial vehicles (uses) that can be used to record data periodically along different trajectories. According to the probability density distribution, the positioning area is segmented to further reduce the location area. Because the algorithm only increases the communication process of the power value of the unknown node and the sensor node, the advantages of the convex programming algorithm are basically preserved to realize the simple and real-time performance. The experimental results show that the improved algorithm has a better positioning accuracy than the original convex programming algorithm.

Towards Inferring Protein Interactions: Challenges and Solutions

NASA Astrophysics Data System (ADS)

Zhang, Ya; Zha, Hongyuan; Chu, Chao-Hsien; Ji, Xiang

2006-12-01

Discovering interacting proteins has been an essential part of functional genomics. However, existing experimental techniques only uncover a small portion of any interactome. Furthermore, these data often have a very high false rate. By conceptualizing the interactions at domain level, we provide a more abstract representation of interactome, which also facilitates the discovery of unobserved protein-protein interactions. Although several domain-based approaches have been proposed to predict protein-protein interactions, they usually assume that domain interactions are independent on each other for the convenience of computational modeling. A new framework to predict protein interactions is proposed in this paper, where no assumption is made about domain interactions. Protein interactions may be the result of multiple domain interactions which are dependent on each other. A conjunctive norm form representation is used to capture the relationships between protein interactions and domain interactions. The problem of interaction inference is then modeled as a constraint satisfiability problem and solved via linear programing. Experimental results on a combined yeast data set have demonstrated the robustness and the accuracy of the proposed algorithm. Moreover, we also map some predicted interacting domains to three-dimensional structures of protein complexes to show the validity of our predictions.

Integrated Kerr comb-based reconfigurable transversal differentiator for microwave photonic signal processing

NASA Astrophysics Data System (ADS)

Xu, Xingyuan; Wu, Jiayang; Shoeiby, Mehrdad; Nguyen, Thach G.; Chu, Sai T.; Little, Brent E.; Morandotti, Roberto; Mitchell, Arnan; Moss, David J.

2018-01-01

An arbitrary-order intensity differentiator for high-order microwave signal differentiation is proposed and experimentally demonstrated on a versatile transversal microwave photonic signal processing platform based on integrated Kerr combs. With a CMOS-compatible nonlinear micro-ring resonator, high quality Kerr combs with broad bandwidth and large frequency spacings are generated, enabling a larger number of taps and an increased Nyquist zone. By programming and shaping individual comb lines' power, calculated tap weights are realized, thus achieving a versatile microwave photonic signal processing platform. Arbitrary-order intensity differentiation is demonstrated on the platform. The RF responses are experimentally characterized, and systems demonstrations for Gaussian input signals are also performed.

Teaching topography-based and selection-based verbal behavior to developmentally disabled individuals: Some considerations

PubMed Central

Shafer, Esther

1993-01-01

Augmentative and alternative communication systems are widely recommended for nonvocal developmentally disabled individuals, with selection-based systems becoming increasingly popular. However, theoretical and experimental evidence suggests that topography-based communication systems are easier to learn. This paper discusses research relevant to the ease of acquisition of topography-based and selection-based systems. Additionally, current practices for choosing and designing communication systems are reviewed in order to investigate the extent to which links have been made with available theoretical and experimental knowledge. A stimulus equivalence model is proposed as a clearer direction for practitioners to follow when planning a communication training program. Suggestions for future research are also offered. PMID:22477085

Redefining Leadership Education in Graduate Public Health Programs: Prioritization, Focus, and Guiding Principles

PubMed Central

Oxendine, Jeffrey S.

2015-01-01

Public health program graduates need leadership skills to be effective in the complex, changing public health environment. We propose a new paradigm for schools of public health in which technical and leadership skills have equal priority as core competencies for graduate students. Leadership education should focus on the foundational skills necessary to effect change independent of formal authority, with activities offered at varying levels of intensity to engage different students. Leadership development initiatives should be practice based, process focused, interdisciplinary, diversity based, adaptive, experimental, innovative, and empowering, and they should encourage authenticity. Leadership training in graduate programs will help lay the groundwork for public health professionals to have an immediate impact in the workforce and to prioritize continuous leadership development throughout their careers. PMID:25706021

Louisiana NASA EPSCoR Preparation Grant

NASA Technical Reports Server (NTRS)

Wefel, John P.; Savoie, E. Joseph

2002-01-01

In August, 1999, the National Aeronautics and Space Administration issued a Cooperative Agreement (CA) to the State of Louisiana, through the Louisiana Board of Regents (BOB), for the performance of scientific research and graduate fellowships under the NASA Experimental Program to Stimulate Competitive Research (EPSCoR) -- Preparation Grant. Originally constructed as a one year program, with an optional one year continuation, this federal-state partnership culminated on 14 August 2002, including a successful continuation proposal and a no cost extension. The total value of the project reached $450K in NASA funding, matched by state funds and institutional contributions. The purpose of the Preparation Grant program was to develop and nurture strong research ties between the state and NASA field centers and Enterprises, in order to prepare for the upcoming full competition for NASA EPSCoR.

Conceptual Design of an In-Space Cryogenic Fluid Management Facility

NASA Technical Reports Server (NTRS)

Willen, G. S.; Riemer, D. H.; Hustvedt, D. C.

1981-01-01

The conceptual design of a Spacelab experiment to develop the technology associated with low gravity propellant management is presented. The proposed facility consisting of a supply tank, receiver tank, pressurization system, instrumentation, and supporting hardware, is described. The experimental objectives, the receiver tank to be modeled, and constraints imposed on the design by the space shuttle, Spacelab, and scaling requirements, are described. The conceptual design, including the general configurations, flow schematics, insulation systems, instrumentation requirements, and internal tank configurations for the supply tank and the receiver tank, is described. Thermal, structural, fluid, and safety and reliability aspects of the facility are analyzed. The facility development plan, including schedule and cost estimates for the facility, is presented. A program work breakdown structure and master program schedule for a seven year program are included.

78 FR 51678 - Market Tests of Experimental Postal Products

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

...] Market Tests of Experimental Postal Products AGENCY: Postal Regulatory Commission. ACTION: Proposed rule... tests of experimental products. The proposed rules address the contents of market test filings, describe... Tests I. Introduction The Commission proposes to establish rules governing market tests of experimental...

Baseline experimental investigation of an electrohydrodynamically assisted heat pipe

NASA Technical Reports Server (NTRS)

Duncan, A. B.

1995-01-01

The increases in power demand and associated thermal management requirements of future space programs such as potential Lunar/Mars missions will require enhancing the operating efficiencies of thermal management devices. Currently, the use of electrohydrodynamically (EHD) assisted thermal control devices is under consideration as a potential method of increasing thermal management system capacity. The objectives of the currently described investigation included completing build-up of the EHD-Assisted Heat Pipe Test bed, developing test procedures for an experimental evaluation of the unassisted heat pipe, developing an analytical model capable of predicting the performance limits of the unassisted heat pipe, and obtaining experimental data which would define the performance characteristics of the unassisted heat pipe. The information obtained in the currently proposed study will be used in order to provide extensive comparisons with the EHD-assisted performance observations to be obtained during the continuing investigation of EHD-Assisted heat transfer devices. Through comparisons of the baseline test bed data and the EHD assisted test bed data, accurate insight into the performance enhancing characteristics of EHD augmentation may be obtained. This may lead to optimization, development, and implementation of EHD technology for future space programs.

Vibration isolation technology: An executive summary of systems development and demonstration

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M.; Logsdon, Kirk A.; Lubomski, Joseph F.

1993-01-01

A program was organized to develop the enabling technologies needed for the use of Space Station Freedom as a viable microgravity experimental platform. One of these development programs was the Vibration Isolation Technology (VIT). This technology development program grew because of increased awareness that the acceleration disturbances present on the Space Transportation System (STS) orbiter can and are detrimental to many microgravity experiments proposed for STS, and in the future, Space Station Freedom (SSF). Overall technological organization are covered of the VIT program. Emphasis is given to the results from development and demonstration of enabling technologies to achieve the acceleration requirements perceived as those most likely needed for a variety of microgravity science experiments. In so doing, a brief summary of general theoretical approaches to controlling the acceleration environment of an isolated space based payload and the design and/or performance of two prototype six degree of freedom active magnetic isolation systems is presented.

Vibration isolation technology - An executive summary of systems development and demonstration

NASA Astrophysics Data System (ADS)

Grodsinsky, C. M.; Logsdon, K. A.; Lubomski, J. F.

1993-01-01

A program was organized to develop the enabling technologies needed for the use of Space Station Freedom as a viable microgravity experimental platform. One of these development programs was the Vibration Isolation Technology (VIT). This technology development program grew because of increased awareness that the acceleration disturbances present on the Space Transportation System (STS) orbiter can and are detrimental to many microgravity experiments proposed for STS, and in the future, Space Station Freedom (SSF). Overall technological organization are covered of the VIT program. Emphasis is given to the results from development and demonstration of enabling technologies to achieve the acceleration requirements perceived as those most likely needed for a variety of microgravity science experiments. In so doing, a brief summary of general theoretical approaches to controlling the acceleration environment of an isolated space based payload and the design and/or performance of two prototype six degree of freedom active magnetic isolation systems is presented.

Developmental Programming of Adult Disease: Reprogramming by Melatonin?

PubMed

Tain, You-Lin; Huang, Li-Tung; Hsu, Chien-Ning

2017-02-16

Adult-onset chronic non-communicable diseases (NCDs) can originate from early life through so-called the "developmental origins of health and disease" (DOHaD) or "developmental programming". The DOHaD concept offers the "reprogramming" strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evidence support that melatonin is closely inter-related to other proposed mechanisms contributing to the developmental programming of a variety of chronic NCDs. Recent animal studies have begun to unravel the multifunctional roles of melatonin in many experimental models of developmental programming. Even though some progress has been made in research on melatonin as a reprogramming strategy to prevent DOHaD-related NCDs, future human studies should aim at filling the translational gap between animal models and clinical trials. Here, we review several key themes on the reprogramming effects of melatonin in DOHaD research. We have particularly focused on the following areas: mechanisms of developmental programming; the interrelationship between melatonin and mechanisms underlying developmental programming; pathophysiological roles of melatonin in pregnancy and fetal development; and insight provided by animal models to support melatonin as a reprogramming therapy. Rates of NCDs are increasing faster than anticipated all over the world. Hence, there is an urgent need to understand reprogramming mechanisms of melatonin and to translate experimental research into clinical practice for halting a growing list of DOHaD-related NCDs.

Sports Training Support Method by Self-Coaching with Humanoid Robot

NASA Astrophysics Data System (ADS)

Toyama, S.; Ikeda, F.; Yasaka, T.

2016-09-01

This paper proposes a new training support method called self-coaching with humanoid robots. In the proposed method, two small size inexpensive humanoid robots are used because of their availability. One robot called target robot reproduces motion of a target player and another robot called reference robot reproduces motion of an expert player. The target player can recognize a target technique from the reference robot and his/her inadequate skill from the target robot. Modifying the motion of the target robot as self-coaching, the target player could get advanced cognition. Some experimental results show some possibility as the new training method and some issues of the self-coaching interface program as a future work.

Dynamic programming in parallel boundary detection with application to ultrasound intima-media segmentation.

PubMed

Zhou, Yuan; Cheng, Xinyao; Xu, Xiangyang; Song, Enmin

2013-12-01

Segmentation of carotid artery intima-media in longitudinal ultrasound images for measuring its thickness to predict cardiovascular diseases can be simplified as detecting two nearly parallel boundaries within a certain distance range, when plaque with irregular shapes is not considered. In this paper, we improve the implementation of two dynamic programming (DP) based approaches to parallel boundary detection, dual dynamic programming (DDP) and piecewise linear dual dynamic programming (PL-DDP). Then, a novel DP based approach, dual line detection (DLD), which translates the original 2-D curve position to a 4-D parameter space representing two line segments in a local image segment, is proposed to solve the problem while maintaining efficiency and rotation invariance. To apply the DLD to ultrasound intima-media segmentation, it is imbedded in a framework that employs an edge map obtained from multiplication of the responses of two edge detectors with different scales and a coupled snake model that simultaneously deforms the two contours for maintaining parallelism. The experimental results on synthetic images and carotid arteries of clinical ultrasound images indicate improved performance of the proposed DLD compared to DDP and PL-DDP, with respect to accuracy and efficiency. Copyright © 2013 Elsevier B.V. All rights reserved.

Near field interaction of microwave signals with a bounded plasma plume

NASA Technical Reports Server (NTRS)

Ling, Hao; Hallock, Gary A.; Kim, Hyeongdong; Birkner, Bjorn

1991-01-01

The objective was to study the effect of the arcjet thruster plume on the performance of an onboard satellite reflector antenna. A project summary is presented along with sections on plasma and electromagnetic modeling. The plasma modeling section includes the following topics: wave propagation; plasma analysis; plume electron density model; and the proposed experimental program. The section on electromagnetic modeling includes new developments in ray modeling and the validation of three dimensional ray results.

Motion capture based identification of the human body inertial parameters.

PubMed

Venture, Gentiane; Ayusawa, Ko; Nakamura, Yoshihiko

2008-01-01

Identification of body inertia, masses and center of mass is an important data to simulate, monitor and understand dynamics of motion, to personalize rehabilitation programs. This paper proposes an original method to identify the inertial parameters of the human body, making use of motion capture data and contact forces measurements. It allows in-vivo painless estimation and monitoring of the inertial parameters. The method is described and then obtained experimental results are presented and discussed.

Mechanical models for the self-organization of tubular patterns.

PubMed

Guo, Chin-Lin

2013-01-01

Organogenesis, such as long tubule self-organization, requires long-range coordination of cell mechanics to arrange cell positions and to remodel the extracellular matrix. While the current mainstream in the field of tissue morphogenesis focuses primarily on genetics and chemical signaling, the influence of cell mechanics on the programming of patterning cues in tissue morphogenesis has not been adequately addressed. Here, we review experimental evidence and propose quantitative mechanical models by which cells can create tubular patterns.

The Krigifier: A Procedure for Generating Pseudorandom Nonlinear Objective Functions for Computational Experimentation

NASA Technical Reports Server (NTRS)

Trosset, Michael W.

1999-01-01

Comprehensive computational experiments to assess the performance of algorithms for numerical optimization require (among other things) a practical procedure for generating pseudorandom nonlinear objective functions. We propose a procedure that is based on the convenient fiction that objective functions are realizations of stochastic processes. This report details the calculations necessary to implement our procedure for the case of certain stationary Gaussian processes and presents a specific implementation in the statistical programming language S-PLUS.

Quantum Strategies: Proposal to Experimentally Test a Quantum Economics Protocol

DTIC Science & Technology

2009-04-09

fact that this al- gorithm requires only bipartite entangled states what makes it feasible to implement, and a key focus of a larger program in quantum...passes through what is effectively a huge Mach-Zender fiber-interferometer bounded by the Sagnac loop and PPBS1- is affected by this time-varying...strategy, no matter what the other players do. As we noted above, this means that there is no (classical) correlated equilibrium other than the Nash

Elastic/viscoplastic behavior of fiber-reinforced thermoplastic composites

NASA Technical Reports Server (NTRS)

Wang, C.; Sun, C. T.; Gates, T. S.

1990-01-01

An elastic/viscoplastic constitutive model was used to characterize the nonlinear and rate dependent behavior of a continuous fiber-reinforced thermoplastic composite. This model was incorporated into a finite element program for the analysis of laminated plates and shells. Details on the finite element formulation with the proposed constitutive model were presented. The numerical results were compared with experimental data for uniaxial tension and three-point bending tests of (+ or - 45 deg)3s APC-2 laminates.

Deterministic analysis of processes at corroding metal surfaces and the study of electrochemical noise in these systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latanision, R.M.

1990-12-01

Electrochemical corrosion is pervasive in virtually all engineering systems and in virtually all industrial circumstances. Although engineers now understand how to design systems to minimize corrosion in many instances, many fundamental questions remain poorly understood and, therefore, the development of corrosion control strategies is based more on empiricism than on a deep understanding of the processes by which metals corrode in electrolytes. Fluctuations in potential, or current, in electrochemical systems have been observed for many years. To date, all investigations of this phenomenon have utilized non-deterministic analyses. In this work it is proposed to study electrochemical noise from a deterministicmore » viewpoint by comparison of experimental parameters, such as first and second order moments (non-deterministic), with computer simulation of corrosion at metal surfaces. In this way it is proposed to analyze the origins of these fluctuations and to elucidate the relationship between these fluctuations and kinetic parameters associated with metal dissolution and cathodic reduction reactions. This research program addresses in essence two areas of interest: (a) computer modeling of corrosion processes in order to study the electrochemical processes on an atomistic scale, and (b) experimental investigations of fluctuations in electrochemical systems and correlation of experimental results with computer modeling. In effect, the noise generated by mathematical modeling will be analyzed and compared to experimental noise in electrochemical systems. 1 fig.« less

The Laser Communications Relay Demonstration Experiment Program

NASA Technical Reports Server (NTRS)

Israel, Dave

2017-01-01

This paper elaborates on the Laser Communications Relay Demonstration (LCRD) Experiment Program, which will engage in a number of pre-determined experiments and also call upon a wide variety of experimenters to test new laser communications technology and techniques, and to gather valuable data. LCRD is a joint project between NASAs Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT LL). LCRD will test the functionality in various settings and scenarios of optical communications links from a GEO payload to ground stations in Southern California and Hawaii over a two-year period following launch in 2019. The LCRD investigator team will execute numerous experiments to test critical aspects of laser communications activities over real links and systems, collecting data on the effects of atmospheric turbulence and weather on performance and communications availability. LCRD will also incorporate emulations of target scenarios, including direct-to-Earth (DTE) links from user spacecraft and optical relay providers supporting user spacecraft. To supplement and expand upon the results of these experiments, the project also includes a Guest Experimenters Program, which encourages individuals and groups from government agencies, academia and industry to propose diverse experiment ideas.

The Laser Communications Relay Demonstration Experiment Program

NASA Technical Reports Server (NTRS)

Israel, David J.; Edwards, Bernard L.; Moores, John D.; Piazzolla, Sabino; Merritt, Scott

2017-01-01

This paper elaborates on the Laser Communications Relay Demonstration (LCRD) Experiment Program, which will engage in a number of pre-determined experiments and also call upon a wide variety of experimenters to test new laser communications technology and techniques, and to gather valuable data. LCRD is a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT LL). LCRD will test the functionality in various settings and scenarios of optical communications links from a GEO (Geosynchronous Earth Orbit) payload to ground stations in Southern California and Hawaii over a two-year period following launch in 2019. The LCRD investigator team will execute numerous experiments to test critical aspects of laser communications activities over real links and systems, collecting data on the effects of atmospheric turbulence and weather on performance and communications availability. LCRD will also incorporate emulations of target scenarios, including direct-to-Earth (DTE) links from user spacecraft and optical relay providers supporting user spacecraft. To supplement and expand upon the results of these experiments, the project also includes a Guest Experimenters Program, which encourages individuals and groups from government agencies, academia and industry to propose diverse experiment ideas.

The use of moments of momentum to account for crystal habits

NASA Technical Reports Server (NTRS)

Barber, P. G.

1985-01-01

A three-step theory of crystal growth is proposed which involves first an association of molecules or ions in solution to form an impinging growth unit, then second the orientation of this unit prior to its impact on the surface of a crystal, and finally the attachment of this unit to the crystal face. From this theory the habit of a crystal is dependent upon the moments of momentum of the impinging growth unit. The results of sample calculations are presented or sodium chloride, succinic acid, sucrose, and chromium boride. The faces predicted by this proposed theory are compared with those predicted by other, energy-based calculations and with those experimentally observed. The proposed theory suggests alternative strategies for crystallization and habit modification which may be of technological importance. Listings of the two computer programs that were used are provided.

A Human-Robot Co-Manipulation Approach Based on Human Sensorimotor Information.

PubMed

Peternel, Luka; Tsagarakis, Nikos; Ajoudani, Arash

2017-07-01

This paper aims to improve the interaction and coordination between the human and the robot in cooperative execution of complex, powerful, and dynamic tasks. We propose a novel approach that integrates online information about the human motor function and manipulability properties into the hybrid controller of the assistive robot. Through this human-in-the-loop framework, the robot can adapt to the human motor behavior and provide the appropriate assistive response in different phases of the cooperative task. We experimentally evaluate the proposed approach in two human-robot co-manipulation tasks that require specific complementary behavior from the two agents. Results suggest that the proposed technique, which relies on a minimum degree of task-level pre-programming, can achieve an enhanced physical human-robot interaction performance and deliver appropriate level of assistance to the human operator.

3D Indoor Positioning of UAVs with Spread Spectrum Ultrasound and Time-of-Flight Cameras

PubMed Central

Aguilera, Teodoro

2017-01-01

This work proposes the use of a hybrid acoustic and optical indoor positioning system for the accurate 3D positioning of Unmanned Aerial Vehicles (UAVs). The acoustic module of this system is based on a Time-Code Division Multiple Access (T-CDMA) scheme, where the sequential emission of five spread spectrum ultrasonic codes is performed to compute the horizontal vehicle position following a 2D multilateration procedure. The optical module is based on a Time-Of-Flight (TOF) camera that provides an initial estimation for the vehicle height. A recursive algorithm programmed on an external computer is then proposed to refine the estimated position. Experimental results show that the proposed system can increase the accuracy of a solely acoustic system by 70–80% in terms of positioning mean square error. PMID:29301211

The Research and Training Activities for the Joint Institute for Aeronautics and Acoustics

NASA Technical Reports Server (NTRS)

Cantwell, Brian

1997-01-01

This proposal requests continued support for the program of activities to be undertaken by the Ames-Stanford Joint Institute for Aeronautics and Acoustics during the one-year period October 1, 1997 to September 30, 1998. The emphasis in this program is on training and research in experimental and computational methods with application to aerodynamics, acoustics and the important interactions between them. The program comprises activities in active flow control, Large Eddy Simulation of jet noise, flap aerodynamics and acoustics, high lift modeling studies and luminescent paint applications. During the proposed period there will be a continued emphasis on the interaction between NASA Ames, Stanford University and Industry, particularly in connection with the noise and high lift activities. The program will be conducted within the general framework of the Memorandum of Understanding (1976) establishing the Institute, as updated in 1993. As outlined in the agreement, the purposes of the Institute include the following: (1) To conduct basic and applied research; (2) to promote joint endeavors between Center scientists and those in the academic community; (3) to provide training to graduate students in specialized areas of aeronautics and acoustics through participation in the research programs of the Institute; (4) to provide opportunities for Post-Doctoral Fellows to collaborate in research programs of the Institute; and (5) to disseminate information about important aeronautical topics and to enable scientists and engineers of the Center to stay abreast of new advances through symposia, seminars and publications.

The Research and Training Activities for the Joint Institute for Aeronautics and Acoustics

NASA Technical Reports Server (NTRS)

Cantwell, Brian

1996-01-01

This proposal requests continued support for the program of activities to be undertaken by the Ames-Stanford Joint Institute for Aeronautics and Acoustics during the one-year period October 1, 1996 to September 30, 1997. The emphasis in this program is on training and research in experimental and computational methods with application to aerodynamics, acoustics and the important interactions between them. The program comprises activities in active flow control, Large Eddy Simulation of jet noise, flap aerodynamics and acoustics, high lift modeling studies and luminescent paint applications. During the proposed period there will be a continued emphasis on the interaction between NASA Ames, Stanford University and Industry, particularly in connection with the noise and high lift activities. The program will be conducted within the general framework of the Memorandum of Understanding (1976) establishing the Institute, as updated in 1993. As outlined in the agreement, the purposes of the institute include the following: To conduct basic and applied research. To promote joint endeavors between Center scientists and those in the academic community To provide training to graduate students in specialized areas of aeronautics and acoustics through participation in the research programs of the Institute. To provide opportunities for Post-Doctoral Fellows to collaborate in research programs of the Institute. To disseminate information about important aeronautical topics and to enable scientists and engineers of the Center to stay abreast of new advances through symposia, seminars and publications.

78 FR 35719 - Endangered and Threatened Wildlife and Plants; Proposed Revision To the Nonessential Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-13

...; Proposed Revision To the Nonessential Experimental Population of the Mexican Wolf AGENCY: Fish and Wildlife...), propose to revise the existing nonessential experimental population designation of the Mexican wolf (Canis... nonessential experimental population designation of Mexican wolves in order to correctly associate this...

The Identification of Scientific Programs to Utilize the Space Environment

NASA Technical Reports Server (NTRS)

Kulacki, F. A.; Nerem, R. M.

1976-01-01

A program to identify and develop ideas for scientific experimentation on the long duration exposure facility (LDEF) was completed. Four research proposals were developed: (1) Ultra pure germanium gamma ray radiation detectors in the space environment, intended to develop and demonstrate an X-ray and gamma-ray spectroscopy system incorporating a temperature cyclable high-purity germanium detector and diode heat pipe cryogenic system for cooling, (2) growth, morphogenesis and metabolism of plant embryos in the zero-gravity environment, to investigate if the space environment induces mutations in the embryogenic cells so that mutants of commercial significance with desirable attributes may be obtained, (3) effect of zero gravity on the growth and pathogenicity of selected zoopathic fungi. It is possible that new kinds of treatment for candidiasis, and tichophytosis could eventuate from the results of the proposed studies, and (4) importance of gravity to survival strategies of small animals. Gravitational effects may be direct or mediate the selection of genetic variants that are preadapted to weightlessness.

Approximate dynamic programming approaches for appointment scheduling with patient preferences.

PubMed

Li, Xin; Wang, Jin; Fung, Richard Y K

2018-04-01

During the appointment booking process in out-patient departments, the level of patient satisfaction can be affected by whether or not their preferences can be met, including the choice of physicians and preferred time slot. In addition, because the appointments are sequential, considering future possible requests is also necessary for a successful appointment system. This paper proposes a Markov decision process model for optimizing the scheduling of sequential appointments with patient preferences. In contrast to existing models, the evaluation of a booking decision in this model focuses on the extent to which preferences are satisfied. Characteristics of the model are analysed to develop a system for formulating booking policies. Based on these characteristics, two types of approximate dynamic programming algorithms are developed to avoid the curse of dimensionality. Experimental results suggest directions for further fine-tuning of the model, as well as improving the efficiency of the two proposed algorithms. Copyright © 2018 Elsevier B.V. All rights reserved.

A robust multi-objective global supplier selection model under currency fluctuation and price discount

NASA Astrophysics Data System (ADS)

Zarindast, Atousa; Seyed Hosseini, Seyed Mohamad; Pishvaee, Mir Saman

2017-06-01

Robust supplier selection problem, in a scenario-based approach has been proposed, when the demand and exchange rates are subject to uncertainties. First, a deterministic multi-objective mixed integer linear programming is developed; then, the robust counterpart of the proposed mixed integer linear programming is presented using the recent extension in robust optimization theory. We discuss decision variables, respectively, by a two-stage stochastic planning model, a robust stochastic optimization planning model which integrates worst case scenario in modeling approach and finally by equivalent deterministic planning model. The experimental study is carried out to compare the performances of the three models. Robust model resulted in remarkable cost saving and it illustrated that to cope with such uncertainties, we should consider them in advance in our planning. In our case study different supplier were selected due to this uncertainties and since supplier selection is a strategic decision, it is crucial to consider these uncertainties in planning approach.

Early Programming of Uterine Tissue by Bisphenol A: Critical Evaluation of Evidence from Animal Exposure Studies

PubMed Central

Suvorov, Alexander; Waxman, David J.

2015-01-01

Exposure to Bisphenol A (BPA) during the critical window of uterine development has been proposed to program the uterus for increased disease susceptibility based on well-documented effects of the potent xenoestrogen diethylstilbestrol. To investigate this proposal, we reviewed 37 studies of prenatal and/or perinatal BPA exposure in animal models and evaluated evidence for: molecular signatures of early BPA exposure; the development of adverse uterine health effects; and epigenetic changes linked to long-term dysregulation of uterine gene expression and health effects. We found substantial evidence for adult uterine effects of early BPA exposure. In contrast, experimental support for epigenetic actions of early BPA exposure is very limited, and largely consists of effects on Hoxa gene DNA methylation. Critical knowledge gaps were identified, including the need to fully characterize short-term and long-term uterine gene responses, interactions with estrogens and other endogenous hormones, and any long-lasting epigenetic signatures that impact adult disease. PMID:26028543

Adaptive learning and control for MIMO system based on adaptive dynamic programming.

PubMed

Fu, Jian; He, Haibo; Zhou, Xinmin

2011-07-01

Adaptive dynamic programming (ADP) is a promising research field for design of intelligent controllers, which can both learn on-the-fly and exhibit optimal behavior. Over the past decades, several generations of ADP design have been proposed in the literature, which have demonstrated many successful applications in various benchmarks and industrial applications. While many of the existing researches focus on multiple-inputs-single-output system with steepest descent search, in this paper we investigate a generalized multiple-input-multiple-output (GMIMO) ADP design for online learning and control, which is more applicable to a wide range of practical real-world applications. Furthermore, an improved weight-updating algorithm based on recursive Levenberg-Marquardt methods is presented and embodied in the GMIMO approach to improve its performance. Finally, we test the performance of this approach based on a practical complex system, namely, the learning and control of the tension and height of the looper system in a hot strip mill. Experimental results demonstrate that the proposed approach can achieve effective and robust performance.

SSP: an interval integer linear programming for de novo transcriptome assembly and isoform discovery of RNA-seq reads.

PubMed

Safikhani, Zhaleh; Sadeghi, Mehdi; Pezeshk, Hamid; Eslahchi, Changiz

2013-01-01

Recent advances in the sequencing technologies have provided a handful of RNA-seq datasets for transcriptome analysis. However, reconstruction of full-length isoforms and estimation of the expression level of transcripts with a low cost are challenging tasks. We propose a novel de novo method named SSP that incorporates interval integer linear programming to resolve alternatively spliced isoforms and reconstruct the whole transcriptome from short reads. Experimental results show that SSP is fast and precise in determining different alternatively spliced isoforms along with the estimation of reconstructed transcript abundances. The SSP software package is available at http://www.bioinf.cs.ipm.ir/software/ssp. © 2013.

Thin Cloud Detection Method by Linear Combination Model of Cloud Image

NASA Astrophysics Data System (ADS)

Liu, L.; Li, J.; Wang, Y.; Xiao, Y.; Zhang, W.; Zhang, S.

2018-04-01

The existing cloud detection methods in photogrammetry often extract the image features from remote sensing images directly, and then use them to classify images into cloud or other things. But when the cloud is thin and small, these methods will be inaccurate. In this paper, a linear combination model of cloud images is proposed, by using this model, the underlying surface information of remote sensing images can be removed. So the cloud detection result can become more accurate. Firstly, the automatic cloud detection program in this paper uses the linear combination model to split the cloud information and surface information in the transparent cloud images, then uses different image features to recognize the cloud parts. In consideration of the computational efficiency, AdaBoost Classifier was introduced to combine the different features to establish a cloud classifier. AdaBoost Classifier can select the most effective features from many normal features, so the calculation time is largely reduced. Finally, we selected a cloud detection method based on tree structure and a multiple feature detection method using SVM classifier to compare with the proposed method, the experimental data shows that the proposed cloud detection program in this paper has high accuracy and fast calculation speed.

Semisupervised Support Vector Machines With Tangent Space Intrinsic Manifold Regularization.

PubMed

Sun, Shiliang; Xie, Xijiong

2016-09-01

Semisupervised learning has been an active research topic in machine learning and data mining. One main reason is that labeling examples is expensive and time-consuming, while there are large numbers of unlabeled examples available in many practical problems. So far, Laplacian regularization has been widely used in semisupervised learning. In this paper, we propose a new regularization method called tangent space intrinsic manifold regularization. It is intrinsic to data manifold and favors linear functions on the manifold. Fundamental elements involved in the formulation of the regularization are local tangent space representations, which are estimated by local principal component analysis, and the connections that relate adjacent tangent spaces. Simultaneously, we explore its application to semisupervised classification and propose two new learning algorithms called tangent space intrinsic manifold regularized support vector machines (TiSVMs) and tangent space intrinsic manifold regularized twin SVMs (TiTSVMs). They effectively integrate the tangent space intrinsic manifold regularization consideration. The optimization of TiSVMs can be solved by a standard quadratic programming, while the optimization of TiTSVMs can be solved by a pair of standard quadratic programmings. The experimental results of semisupervised classification problems show the effectiveness of the proposed semisupervised learning algorithms.

--No Title--

Science.gov Websites

-- OAS Intranet -- Sunday 27 May 2018 Approved Program-Budget 2018 Proposed Program-Budget 2018 Approved Program-Budget 2017 Proposed Program-Budget 2017 Approved Program-Budget 2016 Proposed Program -Budget 2016 Approved Program-Budget 2015 Proposed Program-Budget 2015 Approved Program-Budget 2014

Three-dimensional sensing methodology combining stereo vision and phase-measuring profilometry based on dynamic programming

NASA Astrophysics Data System (ADS)

Lee, Hyunki; Kim, Min Young; Moon, Jeon Il

2017-12-01

Phase measuring profilometry and moiré methodology have been widely applied to the three-dimensional shape measurement of target objects, because of their high measuring speed and accuracy. However, these methods suffer from inherent limitations called a correspondence problem, or 2π-ambiguity problem. Although a kind of sensing method to combine well-known stereo vision and phase measuring profilometry (PMP) technique simultaneously has been developed to overcome this problem, it still requires definite improvement for sensing speed and measurement accuracy. We propose a dynamic programming-based stereo PMP method to acquire more reliable depth information and in a relatively small time period. The proposed method efficiently fuses information from two stereo sensors in terms of phase and intensity simultaneously based on a newly defined cost function of dynamic programming. In addition, the important parameters are analyzed at the view point of the 2π-ambiguity problem and measurement accuracy. To analyze the influence of important hardware and software parameters related to the measurement performance and to verify its efficiency, accuracy, and sensing speed, a series of experimental tests were performed with various objects and sensor configurations.

Inter and intra-modal deformable registration: continuous deformations meet efficient optimal linear programming.

PubMed

Glocker, Ben; Paragios, Nikos; Komodakis, Nikos; Tziritas, Georgios; Navab, Nassir

2007-01-01

In this paper we propose a novel non-rigid volume registration based on discrete labeling and linear programming. The proposed framework reformulates registration as a minimal path extraction in a weighted graph. The space of solutions is represented using a set of a labels which are assigned to predefined displacements. The graph topology corresponds to a superimposed regular grid onto the volume. Links between neighborhood control points introduce smoothness, while links between the graph nodes and the labels (end-nodes) measure the cost induced to the objective function through the selection of a particular deformation for a given control point once projected to the entire volume domain, Higher order polynomials are used to express the volume deformation from the ones of the control points. Efficient linear programming that can guarantee the optimal solution up to (a user-defined) bound is considered to recover the optimal registration parameters. Therefore, the method is gradient free, can encode various similarity metrics (simple changes on the graph construction), can guarantee a globally sub-optimal solution and is computational tractable. Experimental validation using simulated data with known deformation, as well as manually segmented data demonstrate the extreme potentials of our approach.

A Difference-in-Differences Approach to Assess the Effect of a Heat Action Plan on Heat-Related Mortality, and Differences in Effectiveness According to Sex, Age, and Socioeconomic Status (Montreal, Quebec).

PubMed

Benmarhnia, Tarik; Bailey, Zinzi; Kaiser, David; Auger, Nathalie; King, Nicholas; Kaufman, Jay S

2016-11-01

The impact of heat waves on mortality and health inequalities is well documented. Very few studies have assessed the effectiveness of heat action plans (HAPs) on health, and none has used quasi-experimental methods to estimate causal effects of such programs. We developed a quasi-experimental method to estimate the causal effects associated with HAPs that allows the identification of heterogeneity across subpopulations, and to apply this method specifically to the case of the Montreal (Quebec, Canada) HAP. A difference-in-differences approach was undertaken using Montreal death registry data for the summers of 2000-2007 to assess the effectiveness of the Montreal HAP, implemented in 2004, on mortality. To study equity in the effect of HAP implementation, we assessed whether the program effects were heterogeneous across sex (male vs. female), age (≥ 65 years vs. < 65 years), and neighborhood education levels (first vs. third tertile). We conducted sensitivity analyses to assess the validity of the estimated causal effect of the HAP program. We found evidence that the HAP contributed to reducing mortality on hot days, and that the mortality reduction attributable to the program was greater for elderly people and people living in low-education neighborhoods. These findings show promise for programs aimed at reducing the impact of extreme temperatures and health inequities. We propose a new quasi-experimental approach that can be easily applied to evaluate the impact of any program or intervention triggered when daily thresholds are reached. Citation: Benmarhnia T, Bailey Z, Kaiser D, Auger N, King N, Kaufman J. 2016. A difference-in-differences approach to assess the effect of a heat action plan on heat-related mortality, and differences in effectiveness according to sex, age, and socioeconomic status (Montreal, Quebec). Environ Health Perspect 124:1694-1699; http://dx.doi.org/10.1289/EHP203.

34 CFR 387.1 - What is the Experimental and Innovative Training Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true What is the Experimental and Innovative Training Program...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND INNOVATIVE TRAINING General § 387.1 What is the Experimental and Innovative Training Program? This program is...

34 CFR 387.1 - What is the Experimental and Innovative Training Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true What is the Experimental and Innovative Training Program...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND INNOVATIVE TRAINING General § 387.1 What is the Experimental and Innovative Training Program? This program is...

Experimental and Theoretical Study of Propeller Spinner/Shank Interference. M.S. Thesis

NASA Technical Reports Server (NTRS)

Cornell, C. C.

1986-01-01

A fundamental experimental and theoretical investigation into the aerodynamic interference associated with propeller spinner and shank regions was conducted. The research program involved a theoretical assessment of solutions previously proposed, followed by a systematic experimental study to supplement the existing data base. As a result, a refined computational procedure was established for prediction of interference effects in terms of interference drag and resolved into propeller thrust and torque components. These quantities were examined with attention to engineering parameters such as two spinner finess ratios, three blade shank forms, and two/three/four/six/eight blades. Consideration of the physics of the phenomena aided in the logical deduction of two individual interference quantities (cascade effects and spinner/shank juncture interference). These interference effects were semi-empirically modeled using existing theories and placed into a compatible form with an existing propeller performance scheme which provided the basis for examples of application.

[Experimental testing of Pflüger's reflex hypothesis of menstruation in late 19th century].

PubMed

Simmer, H H

1980-07-01

Pflüger's hypothesis of a nerve reflex as the cause of menstruation published in 1865 and accepted by many, nonetheless did not lead to experimental investigations for 25 years. According to this hypothesis the nerve reflex starts in the ovary by an increase of the intraovarian pressure by the growing follicles. In 1884 Adolph Kehrer proposed a program to test the nerve reflex, but only in 1890, Cohnstein artificially increased the intraovarian pressure in women by bimanual compression from the outside and the vagina. His results were not convincing. Six years later, Strassmann injected fluids into ovaries of animals and obtained changes in the uterus resembling those of oestrus. His results seemed to verify a prognosis derived from Pflüger's hypothesis. Thus, after a long interval, that hypothesis had become a paradigma. Though reasons can be given for the delay, it is little understood, why experimental testing started so late.

Development of a Computer-Assisted Instrumentation Curriculum for Physics Students: Using LabVIEW and Arduino Platform

NASA Astrophysics Data System (ADS)

Kuan, Wen-Hsuan; Tseng, Chi-Hung; Chen, Sufen; Wong, Ching-Chang

2016-06-01

We propose an integrated curriculum to establish essential abilities of computer programming for the freshmen of a physics department. The implementation of the graphical-based interfaces from Scratch to LabVIEW then to LabVIEW for Arduino in the curriculum `Computer-Assisted Instrumentation in the Design of Physics Laboratories' brings rigorous algorithm and syntax protocols together with imagination, communication, scientific applications and experimental innovation. The effectiveness of the curriculum was evaluated via statistical analysis of questionnaires, interview responses, the increase in student numbers majoring in physics, and performance in a competition. The results provide quantitative support that the curriculum remove huge barriers to programming which occur in text-based environments, helped students gain knowledge of programming and instrumentation, and increased the students' confidence and motivation to learn physics and computer languages.

Diffusion Analysis Of Hydrogen-Desorption Measurements

NASA Technical Reports Server (NTRS)

Danford, Merlin D.

1988-01-01

Distribution of hydrogen in metal explains observed desorption rate. Report describes application of diffusion theory to anaylsis of experimental data on uptake and elimination of hydrogen in high-strength alloys of 25 degree C. Study part of program aimed at understanding embrittlement of metals by hydrogen. Two nickel-base alloys, Rene 41 and Waspaloy, and one ferrous alloy, 4340 steel, studied. Desorption of hydrogen explained by distribution of hydrogen in metal. "Fast" hydrogen apparently not due to formation of hydrides on and below surface as proposed.

Experimental Evaluation of Performance Feedback Using the Dismounted Infantry Virtual After Action Review System. Long Range Navy and Marine Corps Science and Technology Program

DTIC Science & Technology

2007-11-14

Artificial intelligence and 4 23 education , Volume 1: Learning environments and tutoring systems. Hillsdale, NJ: Erlbaum. Wickens, C.D. (1984). Processing...and how to use it to best optimize the learning process. Some researchers (see Loftin & Savely, 1991) have proposed adding intelligent systems to the...is experienced as the cognitive centers in an individual’s brain process visual, tactile, kinesthetic , olfactory, proprioceptive, and auditory

A theoretical/experimental program to develop active optical pollution sensors

NASA Technical Reports Server (NTRS)

Mills, F. S.; Blais, R. N.; Kindle, E. C.

1977-01-01

Light detection and ranging (LIDAR) technology was applied to the assessment of air quality, and its usefulness was evaluated by actual field tests. Necessary hardware was successfully constructed and operated in the field. Measurements of necessary physical parameters, such as SO2 absorption coefficients were successfully completed and theoretical predictions of differential absorption performance were reported. Plume modeling improvements were proposed. A full scale field test of equipment, data analysis and auxiliary data support was conducted in Maryland during September 1976.

Neonatal corticosterone administration in rodents as a tool to investigate the maternal programming of emotional and immune domains.

PubMed

Macrì, Simone

2017-02-01

Neonatal experiences exert persistent influences on individual development. These influences encompass numerous domains including emotion, cognition, reactivity to external stressors and immunity. The comprehensive nature of the neonatal programming of individual phenotype is reverberated in the large amount of experimental data collected by many authors in several scientific fields: biomedicine, evolutionary and molecular biology. These data support the view that variations in precocious environmental conditions may calibrate the individual phenotype at many different levels. Environmental influences have been traditionally addressed through experimental paradigms entailing the modification of the neonatal environment and the multifactorial (e.g. behaviour, endocrinology, cellular and molecular biology) analysis of the developing individual's phenotype. These protocols suggested that the role of the mother in mediating the offspring's phenotype is often associated with the short-term effects of environmental manipulations on dam's physiology. Specifically, environmental manipulations may induce fluctuations in maternal corticosteroids (corticosterone in rodents) which, in turn, are translated to the offspring through lactation. Herein, I propose that this mother-offspring transfer mechanism can be leveraged to devise experimental protocols based on the exogenous administration of corticosterone during lactation. To support this proposition, I refer to a series of studies in which these protocols have been adopted to investigate the neonatal programming of individual phenotype at the level of emotional and immune regulations. While these paradigms cannot replace traditional studies, I suggest that they can be considered a valid complement.

Neuron recycling for learning the alphabetic principles.

PubMed

Scliar-Cabral, Leonor

2014-01-01

The main purpose of this paper is to discuss an approach to the phonic method of learning-teaching early literacy development, namely that the visual neurons must be recycled to recognize the small differences among pertinent letter features. In addition to the challenge of segmenting the speech chain and the syllable for learning the alphabetic principles, neuroscience has demonstrated another major challenge: neurons in mammals are programmed to process visual signals symmetrically. In order to develop early literacy, visual neurons must be recycled to overcome this initial programming together with phonological awareness, expanding it with the ability to delimit words, including clitics, as well as assigning stress to words. To achieve this goal, Scliar's Early Literacy Development System was proposed and tested. Sixteen subjects (10 girls and 6 boys) comprised the experimental group (mean age 6.02 years), and 16 subjects (7 girls and 9 boys) formed the control group (mean age 6.10 years). The research instruments were a psychosociolinguistic questionnaire to reveal the subjects' profile and a post-test battery of tests. At the beginning of the experiment, the experimental group was submitted to an intervention program based on Scliar's Early Literacy Development System. One of the tests is discussed in this paper, the grapheme-phoneme test: subjects had to read aloud a pseudoword with 4 graphemes, signaled by the experimenter and designed to assess the subject's ability to convert a grapheme into its correspondent phoneme. The average value for the test group was 25.0 correct answers (SD = 11.4); the control group had an average of 14.3 correct answers (SD = 10.6): The difference was significant. The experimental results validate Scliar's Early Literacy Development System and indicate the need to redesign early literacy development methods. © 2014 S. Karger AG, Basel.

76 FR 50737 - Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... notice solicits comments on research entitled ``Experimental Study: Disease Information in Branded Promotional Material.'' The proposed research will explore the nature of including information about a disease...] Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study...

Cost estimate for a proposed GDF Suez LNG testing program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanchat, Thomas K.; Brady, Patrick Dennis; Jernigan, Dann A.

2014-02-01

At the request of GDF Suez, a Rough Order of Magnitude (ROM) cost estimate was prepared for the design, construction, testing, and data analysis for an experimental series of large-scale (Liquefied Natural Gas) LNG spills on land and water that would result in the largest pool fires and vapor dispersion events ever conducted. Due to the expected cost of this large, multi-year program, the authors utilized Sandia's structured cost estimating methodology. This methodology insures that the efforts identified can be performed for the cost proposed at a plus or minus 30 percent confidence. The scale of the LNG spill, fire,more » and vapor dispersion tests proposed by GDF could produce hazard distances and testing safety issues that need to be fully explored. Based on our evaluations, Sandia can utilize much of our existing fire testing infrastructure for the large fire tests and some small dispersion tests (with some modifications) in Albuquerque, but we propose to develop a new dispersion testing site at our remote test area in Nevada because of the large hazard distances. While this might impact some testing logistics, the safety aspects warrant this approach. In addition, we have included a proposal to study cryogenic liquid spills on water and subsequent vaporization in the presence of waves. Sandia is working with DOE on applications that provide infrastructure pertinent to wave production. We present an approach to conduct repeatable wave/spill interaction testing that could utilize such infrastructure.« less

Chronic effects of strength training vs. Hydro aerobics on functional and cardiorespiratory ability in postmenopausal women.

PubMed

Novaes, Giovanni S; Novaes, Jefferson S; Vilaça-Alves, José; Silva, Gabriel Costa E; Garrido, Nuno D; Furtado, Hélio; Reis, Victor M

2014-09-29

The current study aimed to compare the effects of two exercise programs (Strength Training and Hydro Gymnastics) on the functional and cardiorespiratory abilities of Portuguese postmenopausal women. The study population consisted of 38 volunteers (age: 66.9 ± 6.1 years, body mass: 73.70 ± 10.38 kg, and body height: 1.55 ± 0.10 m). Subjects were randomly divided into two experimental groups and one control group: one group performed 24 weeks of strength training (GST; n = 14), another performed 24 weeks of hydro gymnastics (GH; n = 17) and a control group (CG; n = 7), where the subjects continued with their regular daily activities without involvement in any physical exercise program. Three assessments were performed: before the beginning of the program, 12 weeks after the start of the training program and 24 weeks after the start of the program. To assess the functional ability of the participants, several tests proposed by Jones and Rikli (2002) were performed. To evaluate the cardiorespiratory ability of the participants, a modified treadmill Bruce test was applied. Significant differences (p<0.05) were found between the two training methods in the tests, which primarily demanded muscular strength. Body mass and the body mass index showed significant differences during the three stages of assessment in the GST group (p<0.05). With respect to the values that represent the variables of cardiorespiratory ability, positive and significant changes were observed in the two experimental groups. It was concluded that both exercise programs promoted improvements in some indicators of the functional and cardiorespiratory abilities of Portuguese postmenopausal women.

Implementation of a parallel protein structure alignment service on cloud.

PubMed

Hung, Che-Lun; Lin, Yaw-Ling

2013-01-01

Protein structure alignment has become an important strategy by which to identify evolutionary relationships between protein sequences. Several alignment tools are currently available for online comparison of protein structures. In this paper, we propose a parallel protein structure alignment service based on the Hadoop distribution framework. This service includes a protein structure alignment algorithm, a refinement algorithm, and a MapReduce programming model. The refinement algorithm refines the result of alignment. To process vast numbers of protein structures in parallel, the alignment and refinement algorithms are implemented using MapReduce. We analyzed and compared the structure alignments produced by different methods using a dataset randomly selected from the PDB database. The experimental results verify that the proposed algorithm refines the resulting alignments more accurately than existing algorithms. Meanwhile, the computational performance of the proposed service is proportional to the number of processors used in our cloud platform.

Implementation of a Parallel Protein Structure Alignment Service on Cloud

PubMed Central

Hung, Che-Lun; Lin, Yaw-Ling

2013-01-01

Protein structure alignment has become an important strategy by which to identify evolutionary relationships between protein sequences. Several alignment tools are currently available for online comparison of protein structures. In this paper, we propose a parallel protein structure alignment service based on the Hadoop distribution framework. This service includes a protein structure alignment algorithm, a refinement algorithm, and a MapReduce programming model. The refinement algorithm refines the result of alignment. To process vast numbers of protein structures in parallel, the alignment and refinement algorithms are implemented using MapReduce. We analyzed and compared the structure alignments produced by different methods using a dataset randomly selected from the PDB database. The experimental results verify that the proposed algorithm refines the resulting alignments more accurately than existing algorithms. Meanwhile, the computational performance of the proposed service is proportional to the number of processors used in our cloud platform. PMID:23671842

Non-tables look-up search algorithm for efficient H.264/AVC context-based adaptive variable length coding decoding

NASA Astrophysics Data System (ADS)

Han, Yishi; Luo, Zhixiao; Wang, Jianhua; Min, Zhixuan; Qin, Xinyu; Sun, Yunlong

2014-09-01

In general, context-based adaptive variable length coding (CAVLC) decoding in H.264/AVC standard requires frequent access to the unstructured variable length coding tables (VLCTs) and significant memory accesses are consumed. Heavy memory accesses will cause high power consumption and time delays, which are serious problems for applications in portable multimedia devices. We propose a method for high-efficiency CAVLC decoding by using a program instead of all the VLCTs. The decoded codeword from VLCTs can be obtained without any table look-up and memory access. The experimental results show that the proposed algorithm achieves 100% memory access saving and 40% decoding time saving without degrading video quality. Additionally, the proposed algorithm shows a better performance compared with conventional CAVLC decoding, such as table look-up by sequential search, table look-up by binary search, Moon's method, and Kim's method.

Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?

PubMed Central

Tain, You-Lin; Hsu, Chien-Ning

2017-01-01

Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in management. CKD can begin in early life by so-called “developmental programming” or “developmental origins of health and disease” (DOHaD). Early-life insults cause structural and functional changes in the developing kidney, which is called renal programming. Epidemiological and experimental evidence supports the proposition that early-life adverse events lead to renal programming and make subjects vulnerable to developing CKD and its comorbidities in later life. In addition to low nephron endowment, several mechanisms have been proposed for renal programming. The DOHaD concept opens a new window to offset the programming process in early life to prevent the development of adult kidney disease, namely reprogramming. Here, we review the key themes on the developmental origins of CKD. We have particularly focused on the following areas: evidence from human studies support fetal programming of kidney disease; insight from animal models of renal programming; hypothetical mechanisms of renal programming; alterations of renal transcriptome in response to early-life insults; and the application of reprogramming interventions to prevent the programming of kidney disease. PMID:28208659

The TEF modeling and analysis approach to advance thermionic space power technology

NASA Astrophysics Data System (ADS)

Marshall, Albert C.

1997-01-01

Thermionics space power systems have been proposed as advanced power sources for future space missions that require electrical power levels significantly above the capabilities of current space power systems. The Defense Special Weapons Agency's (DSWA) Thermionic Evaluation Facility (TEF) is carrying out both experimental and analytical research to advance thermionic space power technology to meet this expected need. A Modeling and Analysis (M&A) project has been created at the TEF to develop analysis tools, evaluate concepts, and guide research. M&A activities are closely linked to the TEF experimental program, providing experiment support and using experimental data to validate models. A planning exercise has been completed for the M&A project, and a strategy for implementation was developed. All M&A activities will build on a framework provided by a system performance model for a baseline Thermionic Fuel Element (TFE) concept. The system model is composed of sub-models for each of the system components and sub-systems. Additional thermionic component options and model improvements will continue to be incorporated in the basic system model during the course of the program. All tasks are organized into four focus areas: 1) system models, 2) thermionic research, 3) alternative concepts, and 4) documentation and integration. The M&A project will provide a solid framework for future thermionic system development.

Computational approaches to protein inference in shotgun proteomics

PubMed Central

2012-01-01

Shotgun proteomics has recently emerged as a powerful approach to characterizing proteomes in biological samples. Its overall objective is to identify the form and quantity of each protein in a high-throughput manner by coupling liquid chromatography with tandem mass spectrometry. As a consequence of its high throughput nature, shotgun proteomics faces challenges with respect to the analysis and interpretation of experimental data. Among such challenges, the identification of proteins present in a sample has been recognized as an important computational task. This task generally consists of (1) assigning experimental tandem mass spectra to peptides derived from a protein database, and (2) mapping assigned peptides to proteins and quantifying the confidence of identified proteins. Protein identification is fundamentally a statistical inference problem with a number of methods proposed to address its challenges. In this review we categorize current approaches into rule-based, combinatorial optimization and probabilistic inference techniques, and present them using integer programing and Bayesian inference frameworks. We also discuss the main challenges of protein identification and propose potential solutions with the goal of spurring innovative research in this area. PMID:23176300

Supersonic Aerodynamic Characteristics of Proposed Mars '07 Smart Lander Configurations

NASA Technical Reports Server (NTRS)

Murphy, Kelly J.; Horvath, Thomas J.; Erickson, Gary E.; Green, Joseph M.

2002-01-01

Supersonic aerodynamic data were obtained for proposed Mars '07 Smart Lander configurations in NASA Langley Research Center's Unitary Plan Wind Tunnel. The primary objective of this test program was to assess the supersonic aerodynamic characteristics of the baseline Smart Lander configuration with and without fixed shelf/tab control surfaces. Data were obtained over a Mach number range of 2.3 to 4.5, at a free stream Reynolds Number of 1 x 10(exp 6) based on body diameter. All configurations were run at angles of attack from -5 to 20 degrees and angles of sideslip of -5 to 5 degrees. These results were complemented with computational fluid dynamic (CFD) predictions to enhance the understanding of experimentally observed aerodynamic trends. Inviscid and viscous full model CFD solutions compared well with experimental results for the baseline and 3 shelf/tab configurations. Over the range tested, Mach number effects were shown to be small on vehicle aerodynamic characteristics. Based on the results from 3 different shelf/tab configurations, a fixed control surface appears to be a feasible concept for meeting aerodynamic performance metrics necessary to satisfy mission requirements.

Combustion characteristics and turbulence modeling of swirling reacting flow in solid fuel ramjet

NASA Astrophysics Data System (ADS)

Musa, Omer; Xiong, Chen; Changsheng, Zhou

2017-10-01

This paper reviews the historical studies have been done on the solid-fuel ramjet engine and difficulties associated with numerical modeling of swirling flow with combustible gases. A literature survey about works related to numerical and experimental investigations on solid-fuel ramjet as well as using swirling flow and different numerical approaches has been provided. An overview of turbulence modeling of swirling flow and the behavior of turbulence at streamline curvature and system rotation are presented. A new and simple curvature/correction factor is proposed in order to reduce the programming complexity of SST-CC turbulence model. Finally, numerical and experimental investigations on the impact of swirling flow on SFRJ have been carried out. For that regard, a multi-physics coupling code is developed to solve the problems of multi-physics coupling of fluid mechanics, solid pyrolysis, heat transfer, thermodynamics, and chemical kinetics. The connected-pipe test facility is used to carry out the experiments. The results showed a positive impact of swirling flow on SFRJ along with, three correlations are proposed.

The Alpha-Helix Concept: Innovative utilization of the Space Station Program. A report to the National Aeronautical and Space Administration requesting establishment of a Sensory Physiology Laboratory on the Space Station

NASA Technical Reports Server (NTRS)

Bandurski, R. S.; Singh, N.

1983-01-01

A major laboratory dedicated to biological-medical research is proposed for the Space Platform. The laboratory would focus on sensor physiology and biochemistry since sensory physiology represents the first impact of the new space environment on living organisms. Microgravity and the high radiation environment of space would be used to help solve the problems of prolonged sojourns in space but, more importantly, to help solve terrestrial problems of human health and agricultural productivity. The emphasis would be on experimental use of microorganisms and small plants and small animals to minimize the space and time required to use the Space Platform for maximum human betterment. The Alpha Helix Concept, that is, the use of the Space Platform to bring experimental biomedicine to a new and extreme frontier is introduced so as to better understand the worldly environment. Staffing and instrumenting the Space Platform biomedical laboratory in a manner patterned after successful terrestrial sensory physiology laboratories is also proposed.

The Alpha-Helix Concept: Innovative utilization of the Space Station Program. A report to the National Aeronautical and Space Administration requesting establishment of a Sensory Physiology Laboratory on the Space Station

NASA Astrophysics Data System (ADS)

Bandurski, R. S.; Singh, N.

1983-10-01

A major laboratory dedicated to biological-medical research is proposed for the Space Platform. The laboratory would focus on sensor physiology and biochemistry since sensory physiology represents the first impact of the new space environment on living organisms. Microgravity and the high radiation environment of space would be used to help solve the problems of prolonged sojourns in space but, more importantly, to help solve terrestrial problems of human health and agricultural productivity. The emphasis would be on experimental use of microorganisms and small plants and small animals to minimize the space and time required to use the Space Platform for maximum human betterment. The Alpha Helix Concept, that is, the use of the Space Platform to bring experimental biomedicine to a new and extreme frontier is introduced so as to better understand the worldly environment. Staffing and instrumenting the Space Platform biomedical laboratory in a manner patterned after successful terrestrial sensory physiology laboratories is also proposed.

A statistical approach to optimizing concrete mixture design.

PubMed

Ahmad, Shamsad; Alghamdi, Saeid A

2014-01-01

A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according to a full factorial experiment design involving three factors and their three levels (3(3)). A total of 27 concrete mixtures with three replicates (81 specimens) were considered by varying the levels of key factors affecting compressive strength of concrete, namely, water/cementitious materials ratio (0.38, 0.43, and 0.48), cementitious materials content (350, 375, and 400 kg/m(3)), and fine/total aggregate ratio (0.35, 0.40, and 0.45). The experimental data were utilized to carry out analysis of variance (ANOVA) and to develop a polynomial regression model for compressive strength in terms of the three design factors considered in this study. The developed statistical model was used to show how optimization of concrete mixtures can be carried out with different possible options.

A Statistical Approach to Optimizing Concrete Mixture Design

PubMed Central

Alghamdi, Saeid A.

2014-01-01

A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according to a full factorial experiment design involving three factors and their three levels (33). A total of 27 concrete mixtures with three replicates (81 specimens) were considered by varying the levels of key factors affecting compressive strength of concrete, namely, water/cementitious materials ratio (0.38, 0.43, and 0.48), cementitious materials content (350, 375, and 400 kg/m3), and fine/total aggregate ratio (0.35, 0.40, and 0.45). The experimental data were utilized to carry out analysis of variance (ANOVA) and to develop a polynomial regression model for compressive strength in terms of the three design factors considered in this study. The developed statistical model was used to show how optimization of concrete mixtures can be carried out with different possible options. PMID:24688405

Optimizing Crawler4j using MapReduce Programming Model

NASA Astrophysics Data System (ADS)

Siddesh, G. M.; Suresh, Kavya; Madhuri, K. Y.; Nijagal, Madhushree; Rakshitha, B. R.; Srinivasa, K. G.

2017-06-01

World wide web is a decentralized system that consists of a repository of information on the basis of web pages. These web pages act as a source of information or data in the present analytics world. Web crawlers are used for extracting useful information from web pages for different purposes. Firstly, it is used in web search engines where the web pages are indexed to form a corpus of information and allows the users to query on the web pages. Secondly, it is used for web archiving where the web pages are stored for later analysis phases. Thirdly, it can be used for web mining where the web pages are monitored for copyright purposes. The amount of information processed by the web crawler needs to be improved by using the capabilities of modern parallel processing technologies. In order to solve the problem of parallelism and the throughput of crawling this work proposes to optimize the Crawler4j using the Hadoop MapReduce programming model by parallelizing the processing of large input data. Crawler4j is a web crawler that retrieves useful information about the pages that it visits. The crawler Crawler4j coupled with data and computational parallelism of Hadoop MapReduce programming model improves the throughput and accuracy of web crawling. The experimental results demonstrate that the proposed solution achieves significant improvements with respect to performance and throughput. Hence the proposed approach intends to carve out a new methodology towards optimizing web crawling by achieving significant performance gain.

Surgical Neuroanatomy and Programming in Deep Brain Stimulation for Obsessive Compulsive Disorder

PubMed Central

Morishita, Takashi; Fayad, Sarah M.; Goodman, Wayne K.; Foote, Kelly D.; Chen, Dennis; Peace, David A.; Rhoton, Albert L.; Okun, Michael S.

2014-01-01

Objectives Deep brain stimulation (DBS) has been established as a safe, effective therapy for movement disorders (Parkinson’s disease, essential tremor, etc.), and its application is expanding to the treatment of other intractable neuropsychiatric disorders including Depression and Obsessive-Compulsive Disorder (OCD). Several published studies have supported the efficacy of DBS for severely debilitating OCD. However, questions remain regarding the optimal anatomical target and the lack of a bedside programming paradigm for OCD DBS. Management of OCD DBS can be highly variable and is typically guided by each center’s individual expertise. In this paper, we review the various approaches to targeting and programming for OCD DBS. We also review the clinical experience for each proposed target, and discuss the relevant neuroanatomy. Methods A PubMed review was performed searching for literature on OCD DBS and included all articles published before March 2012. We included all available studies with a clear description of the anatomical targets, programming details, and the outcomes. Results Six different DBS approaches were identified. High frequency stimulation with high voltage was applied in most cases, and predictive factors for favorable outcomes were discussed in the literature. Conclusion DBS remains an experimental treatment for medication refractory OCD. Target selection and programming paradigms are not yet standardized, though, an improved understanding of the relationship between the DBS lead and the surrounding neuroanatomical structures will aid in the selection of targets and the approach to programming. We propose to form a registry to track OCD DBS cases for future clinical study design. PMID:24345303

Surgical neuroanatomy and programming in deep brain stimulation for obsessive compulsive disorder.

PubMed

Morishita, Takashi; Fayad, Sarah M; Goodman, Wayne K; Foote, Kelly D; Chen, Dennis; Peace, David A; Rhoton, Albert L; Okun, Michael S

2014-06-01

Deep brain stimulation (DBS) has been established as a safe, effective therapy for movement disorders (Parkinson's disease, essential tremor, etc.), and its application is expanding to the treatment of other intractable neuropsychiatric disorders including depression and obsessive-compulsive disorder (OCD). Several published studies have supported the efficacy of DBS for severely debilitating OCD. However, questions remain regarding the optimal anatomic target and the lack of a bedside programming paradigm for OCD DBS. Management of OCD DBS can be highly variable and is typically guided by each center's individual expertise. In this paper, we review the various approaches to targeting and programming for OCD DBS. We also review the clinical experience for each proposed target and discuss the relevant neuroanatomy. A PubMed review was performed searching for literature on OCD DBS and included all articles published before March 2012. We included all available studies with a clear description of the anatomic targets, programming details, and the outcomes. Six different DBS approaches were identified. High-frequency stimulation with high voltage was applied in most cases, and predictive factors for favorable outcomes were discussed in the literature. DBS remains an experimental treatment for medication refractory OCD. Target selection and programming paradigms are not yet standardized, though an improved understanding of the relationship between the DBS lead and the surrounding neuroanatomic structures will aid in the selection of targets and the approach to programming. We propose to form a registry to track OCD DBS cases for future clinical study design. © 2013 International Neuromodulation Society.

ProMC: Input-output data format for HEP applications using varint encoding

NASA Astrophysics Data System (ADS)

Chekanov, S. V.; May, E.; Strand, K.; Van Gemmeren, P.

2014-10-01

A new data format for Monte Carlo (MC) events, or any structural data, including experimental data, is discussed. The format is designed to store data in a compact binary form using variable-size integer encoding as implemented in the Google's Protocol Buffers package. This approach is implemented in the PROMC library which produces smaller file sizes for MC records compared to the existing input-output libraries used in high-energy physics (HEP). Other important features of the proposed format are a separation of abstract data layouts from concrete programming implementations, self-description and random access. Data stored in PROMC files can be written, read and manipulated in a number of programming languages, such C++, JAVA, FORTRAN and PYTHON.

Multitask visual learning using genetic programming.

PubMed

Jaśkowski, Wojciech; Krawiec, Krzysztof; Wieloch, Bartosz

2008-01-01

We propose a multitask learning method of visual concepts within the genetic programming (GP) framework. Each GP individual is composed of several trees that process visual primitives derived from input images. Two trees solve two different visual tasks and are allowed to share knowledge with each other by commonly calling the remaining GP trees (subfunctions) included in the same individual. The performance of a particular tree is measured by its ability to reproduce the shapes contained in the training images. We apply this method to visual learning tasks of recognizing simple shapes and compare it to a reference method. The experimental verification demonstrates that such multitask learning often leads to performance improvements in one or both solved tasks, without extra computational effort.

Interactive contour delineation and refinement in treatment planning of image‐guided radiation therapy

PubMed Central

Zhou, Wu

2014-01-01

The accurate contour delineation of the target and/or organs at risk (OAR) is essential in treatment planning for image‐guided radiation therapy (IGRT). Although many automatic contour delineation approaches have been proposed, few of them can fulfill the necessities of applications in terms of accuracy and efficiency. Moreover, clinicians would like to analyze the characteristics of regions of interests (ROI) and adjust contours manually during IGRT. Interactive tool for contour delineation is necessary in such cases. In this work, a novel approach of curve fitting for interactive contour delineation is proposed. It allows users to quickly improve contours by a simple mouse click. Initially, a region which contains interesting object is selected in the image, then the program can automatically select important control points from the region boundary, and the method of Hermite cubic curves is used to fit the control points. Hence, the optimized curve can be revised by moving its control points interactively. Meanwhile, several curve fitting methods are presented for the comparison. Finally, in order to improve the accuracy of contour delineation, the process of the curve refinement based on the maximum gradient magnitude is proposed. All the points on the curve are revised automatically towards the positions with maximum gradient magnitude. Experimental results show that Hermite cubic curves and the curve refinement based on the maximum gradient magnitude possess superior performance on the proposed platform in terms of accuracy, robustness, and time calculation. Experimental results of real medical images demonstrate the efficiency, accuracy, and robustness of the proposed process in clinical applications. PACS number: 87.53.Tf PMID:24423846

Cross-species 3D virtual reality toolbox for visual and cognitive experiments.

PubMed

Doucet, Guillaume; Gulli, Roberto A; Martinez-Trujillo, Julio C

2016-06-15

Although simplified visual stimuli, such as dots or gratings presented on homogeneous backgrounds, provide strict control over the stimulus parameters during visual experiments, they fail to approximate visual stimulation in natural conditions. Adoption of virtual reality (VR) in neuroscience research has been proposed to circumvent this problem, by combining strict control of experimental variables and behavioral monitoring within complex and realistic environments. We have created a VR toolbox that maximizes experimental flexibility while minimizing implementation costs. A free VR engine (Unreal 3) has been customized to interface with any control software via text commands, allowing seamless introduction into pre-existing laboratory data acquisition frameworks. Furthermore, control functions are provided for the two most common programming languages used in visual neuroscience: Matlab and Python. The toolbox offers milliseconds time resolution necessary for electrophysiological recordings and is flexible enough to support cross-species usage across a wide range of paradigms. Unlike previously proposed VR solutions whose implementation is complex and time-consuming, our toolbox requires minimal customization or technical expertise to interface with pre-existing data acquisition frameworks as it relies on already familiar programming environments. Moreover, as it is compatible with a variety of display and input devices, identical VR testing paradigms can be used across species, from rodents to humans. This toolbox facilitates the addition of VR capabilities to any laboratory without perturbing pre-existing data acquisition frameworks, or requiring any major hardware changes. Copyright © 2016 Z. All rights reserved.

Fostering Career Awareness in Elementary Schools: Evaluation of an Intervention Proposal.

PubMed

Carvalho, Renato Gomes; Pocinho, Margarida; Fernandes, Débora

2018-05-17

Research literature has been increasingly focusing on children's career development, especially when school contexts are considered. In the present study, we evaluate the efficacy of a short-term intervention program designed to foster career awareness in elementary school. The sample consisted of 155 Portuguese fifth- and sixth-grade students, aged nine to fifteen years old (M = 11, SD = 1). With a quasi-experimental design, the sample was divided into two groups, namely, the participants in the program and the controls. We used the Career Awareness Scale for Children and a sociodemographic survey. Analyses of covariance indicated a moderate effect of the participation in the program in students' career awareness (ηp2 = .06, p = .003). The results are discussed considering the school as a key context for career education aiming at promoting students' adaptability and involvement in the construction of their life pathways.

Research program for a search of the origin of Darwinian evolution. Research program for a vesicle-based model of the origin of Darwinian evolution on prebiotic early Earth

NASA Astrophysics Data System (ADS)

Tessera, Marc

2017-03-01

The search for origin of `life' is made even more complicated by differing definitions of the subject matter, although a general consensus is that an appropriate definition should center on Darwinian evolution (Cleland and Chyba 2002). Within a physical approach which has been defined as a level-4 evolution (Tessera and Hoelzer 2013), one mechanism could be described showing that only three conditions are required to allow natural selection to apply to populations of different system lineages. This approach leads to a vesicle- based model with the necessary properties. Of course such a model has to be tested. Thus, after a brief presentation of the model an experimental program is proposed that implements the different steps able to show whether this new direction of the research in the field is valid and workable.

Research program for a search of the origin of Darwinian evolution : Research program for a vesicle-based model of the origin of Darwinian evolution on prebiotic early Earth.

PubMed

Tessera, Marc

2017-03-01

The search for origin of 'life' is made even more complicated by differing definitions of the subject matter, although a general consensus is that an appropriate definition should center on Darwinian evolution (Cleland and Chyba 2002). Within a physical approach which has been defined as a level-4 evolution (Tessera and Hoelzer 2013), one mechanism could be described showing that only three conditions are required to allow natural selection to apply to populations of different system lineages. This approach leads to a vesicle- based model with the necessary properties. Of course such a model has to be tested. Thus, after a brief presentation of the model an experimental program is proposed that implements the different steps able to show whether this new direction of the research in the field is valid and workable.

A Multiobjective Interval Programming Model for Wind-Hydrothermal Power System Dispatching Using 2-Step Optimization Algorithm

PubMed Central

Jihong, Qu

2014-01-01

Wind-hydrothermal power system dispatching has received intensive attention in recent years because it can help develop various reasonable plans to schedule the power generation efficiency. But future data such as wind power output and power load would not be accurately predicted and the nonlinear nature involved in the complex multiobjective scheduling model; therefore, to achieve accurate solution to such complex problem is a very difficult task. This paper presents an interval programming model with 2-step optimization algorithm to solve multiobjective dispatching. Initially, we represented the future data into interval numbers and simplified the object function to a linear programming problem to search the feasible and preliminary solutions to construct the Pareto set. Then the simulated annealing method was used to search the optimal solution of initial model. Thorough experimental results suggest that the proposed method performed reasonably well in terms of both operating efficiency and precision. PMID:24895663

A multiobjective interval programming model for wind-hydrothermal power system dispatching using 2-step optimization algorithm.

PubMed

Ren, Kun; Jihong, Qu

2014-01-01

Wind-hydrothermal power system dispatching has received intensive attention in recent years because it can help develop various reasonable plans to schedule the power generation efficiency. But future data such as wind power output and power load would not be accurately predicted and the nonlinear nature involved in the complex multiobjective scheduling model; therefore, to achieve accurate solution to such complex problem is a very difficult task. This paper presents an interval programming model with 2-step optimization algorithm to solve multiobjective dispatching. Initially, we represented the future data into interval numbers and simplified the object function to a linear programming problem to search the feasible and preliminary solutions to construct the Pareto set. Then the simulated annealing method was used to search the optimal solution of initial model. Thorough experimental results suggest that the proposed method performed reasonably well in terms of both operating efficiency and precision.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nabeel Riza

In this program, Nuonics, Inc. has studied the fundamentals of a new Silicon Carbide (SiC) materials-based optical sensor technology suited for extreme environments of coal-fired engines in power production. The program explored how SiC could be used for sensing temperature, pressure, and potential gas species in a gas turbine environment. The program successfully demonstrated the optical designs, signal processing and experimental data for enabling both temperature and pressure sensing using SiC materials. The program via its sub-contractors also explored gas species sensing using SiC, in this case, no clear commercially deployable method was proven. Extensive temperature and pressure measurement datamore » using the proposed SiC sensors was acquired to 1000 deg-C and 40 atms, respectively. Importantly, a first time packaged all-SiC probe design was successfully operated in a Siemens industrial turbine rig facility with the probe surviving the harsh chemical, pressure, and temperature environment during 28 days of test operations. The probe also survived a 1600 deg-C thermal shock test using an industrial flame.« less

Single Axis Flywheel IPACS @1300W, 0.8 N-m

NASA Technical Reports Server (NTRS)

Jansen, Ralph; Kenny, Barbara; Kascak, Peter; Dever, Tim; Santiago, Walter

2005-01-01

NASA Glenn Research Center is developing flywheels for space systems. A single axis laboratory version of an integrated power and attitude control (IPACs) system has been experimentally demonstrated. This is a significant step on the road to a flight qualified three axes IPACS system. The presentation outlines the flywheel development process at NASA GRC, the experimental hardware and approach, the IPACS control algorithm that was formulated and the results of the test program and then proposes a direction for future work. GRC has made progress on flywheel module design in terms of specific energy density and capability through a design and test program resulting in three flywheel module designs. Two of the flywheels are used in the 1D-IPACS experiment with loads and power sources to simulate a satellite power system. The system response is measured in three power modes: charge, discharge, and charge reduction while simultaneously producing a net output torque which could be used for attitude control. Finally, recommendations are made for steps that should be taken to evolve from this laboratory demonstration to a flight like system.

PROPOSAL FOR AN EXPERIMENT PROGRAM IN NEUTRINO PHYSICS AND PROTON DECAY IN THE HOMESTAKE LABORATORY.

DOE Office of Scientific and Technical Information (OSTI.GOV)

DIWAN, M.; KETTELL, S.; LITTENBERG, W.

2006-07-24

This report is intended to describe first, the principal physics reasons for an ambitious experimental program in neutrino physics and proton decay based on construction of a series of massive water Cherenkov detectors located deep underground (4850 ft) in the Homestake Mine of the South Dakota Science and Technology Authority (SDSTA); and second, the engineering design of the underground chambers to house the Cherenkov detector modules; and third, the conceptual design of the water Cherenkov detectors themselves for this purpose. In this proposal we show the event rates and physics sensitivity for beams from both FNAL (1300 km distant frommore » Homestake) and BNL (2540 km distant from Homestake). The program we propose will benefit with a beam from FNAL because of the high intensities currently available from the Main Injector with modest upgrades. The possibility of tuning the primary proton energy over a large range from 30 to 120 GeV also adds considerable flexibility to the program from FNAL. On the other hand the beam from BNL over the larger distance will produce very large matter effects, and consequently a hint of new physics (beyond CP violation) can be better tested with that configuration. In this proposal we focus on the CP violation physics. Included in this document are preliminary costs and time-to-completion estimates which have been exposed to acknowledged experts in their respective areas. This presentation is not, however, to be taken as a technical design report with the extensive documentation and contingency costs that a TDR usually entails. Nevertheless, some contingency factors have been included in the estimates given here. The essential ideas expressed here were first laid out in a letter of intent to the interim director of the Homestake Laboratory on July 26, 2001. Since that time, the prospect of a laboratory in the Homestake Mine has been realized, and the design of a long baseline neutrino experiment has been refined. The extrapolation contained in this proposal is within the common domain of thinking in the area of physics discussed here. It needs now only the encouragement of the funding agencies, NSF and DOE.« less

Simulation of patient flow in multiple healthcare units using process and data mining techniques for model identification.

PubMed

Kovalchuk, Sergey V; Funkner, Anastasia A; Metsker, Oleg G; Yakovlev, Aleksey N

2018-06-01

An approach to building a hybrid simulation of patient flow is introduced with a combination of data-driven methods for automation of model identification. The approach is described with a conceptual framework and basic methods for combination of different techniques. The implementation of the proposed approach for simulation of the acute coronary syndrome (ACS) was developed and used in an experimental study. A combination of data, text, process mining techniques, and machine learning approaches for the analysis of electronic health records (EHRs) with discrete-event simulation (DES) and queueing theory for the simulation of patient flow was proposed. The performed analysis of EHRs for ACS patients enabled identification of several classes of clinical pathways (CPs) which were used to implement a more realistic simulation of the patient flow. The developed solution was implemented using Python libraries (SimPy, SciPy, and others). The proposed approach enables more a realistic and detailed simulation of the patient flow within a group of related departments. An experimental study shows an improved simulation of patient length of stay for ACS patient flow obtained from EHRs in Almazov National Medical Research Centre in Saint Petersburg, Russia. The proposed approach, methods, and solutions provide a conceptual, methodological, and programming framework for the implementation of a simulation of complex and diverse scenarios within a flow of patients for different purposes: decision making, training, management optimization, and others. Copyright © 2018 Elsevier Inc. All rights reserved.

Intra-retinal segmentation of optical coherence tomography images using active contours with a dynamic programming initialization and an adaptive weighting strategy

NASA Astrophysics Data System (ADS)

Gholami, Peyman; Roy, Priyanka; Kuppuswamy Parthasarathy, Mohana; Ommani, Abbas; Zelek, John; Lakshminarayanan, Vasudevan

2018-02-01

Retinal layer shape and thickness are one of the main indicators in the diagnosis of ocular diseases. We present an active contour approach to localize intra-retinal boundaries of eight retinal layers from OCT images. The initial locations of the active contour curves are determined using a Viterbi dynamic programming method. The main energy function is a Chan-Vese active contour model without edges. A boundary term is added to the energy function using an adaptive weighting method to help curves converge to the retinal layer edges more precisely, after evolving of curves towards boundaries, in final iterations. A wavelet-based denoising method is used to remove speckle from OCT images while preserving important details and edges. The performance of the proposed method was tested on a set of healthy and diseased eye SD-OCT images. The experimental results, compared between the proposed method and the manual segmentation, which was determined by an optometrist, indicate that our method has obtained an average of 95.29%, 92.78%, 95.86%, 87.93%, 82.67%, and 90.25% respectively, for accuracy, sensitivity, specificity, precision, Jaccard Index, and Dice Similarity Coefficient over all segmented layers. These results justify the robustness of the proposed method in determining the location of different retinal layers.

Increasing the computational efficient of digital cross correlation by a vectorization method

NASA Astrophysics Data System (ADS)

Chang, Ching-Yuan; Ma, Chien-Ching

2017-08-01

This study presents a vectorization method for use in MATLAB programming aimed at increasing the computational efficiency of digital cross correlation in sound and images, resulting in a speedup of 6.387 and 36.044 times compared with performance values obtained from looped expression. This work bridges the gap between matrix operations and loop iteration, preserving flexibility and efficiency in program testing. This paper uses numerical simulation to verify the speedup of the proposed vectorization method as well as experiments to measure the quantitative transient displacement response subjected to dynamic impact loading. The experiment involved the use of a high speed camera as well as a fiber optic system to measure the transient displacement in a cantilever beam under impact from a steel ball. Experimental measurement data obtained from the two methods are in excellent agreement in both the time and frequency domain, with discrepancies of only 0.68%. Numerical and experiment results demonstrate the efficacy of the proposed vectorization method with regard to computational speed in signal processing and high precision in the correlation algorithm. We also present the source code with which to build MATLAB-executable functions on Windows as well as Linux platforms, and provide a series of examples to demonstrate the application of the proposed vectorization method.

34 CFR 387.1 - What is the Experimental and Innovative Training Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false What is the Experimental and Innovative Training... (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND INNOVATIVE TRAINING General § 387.1 What is the Experimental and Innovative Training Program? This program is...

34 CFR 387.1 - What is the Experimental and Innovative Training Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false What is the Experimental and Innovative Training... (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND INNOVATIVE TRAINING General § 387.1 What is the Experimental and Innovative Training Program? This program is...

34 CFR 387.1 - What is the Experimental and Innovative Training Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 2 2013-07-01 2013-07-01 false What is the Experimental and Innovative Training... (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND INNOVATIVE TRAINING General § 387.1 What is the Experimental and Innovative Training Program? This program is...

Scanning tunnelling microscope for boron surface studies

NASA Astrophysics Data System (ADS)

Trenary, Michael

1990-10-01

The equipment purchased is to be used in an experimental study of the relationship between atomic structure and chemical reactivity for boron and carbon surfaces. This research is currently being supported by grant AFOSR-88-0111. A renewal proposal is currently pending with AFOSR to continue these studies. Carbon and boron are exceptionally stable, covalently bonded solids with highly unique crystal structures. The specific reactions to be studied are loosely related to the problems of oxidation and oxidation inhibition of carbon/carbon composites. The main experimental instrument to be used is a scanning tunneling microscope (STM) purchased under grant number AFSOR-89-0146. Other techniques to be used include Auger electron spectroscopy, X-ray photoelectron spectroscopy (XPS), ultraviolet photoelectron spectroscopy (UPS), low energy electron diffraction (LEED), temperature programmed desorption (TPD) and scanning tunneling microscopy (STM).

77 FR 18250 - Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... of information technology. Experimental Study of Graphic Cigarette Warning Labels--(OMB Control... graphic warnings required by the Tobacco Control Act. The experimental study data will be collected from...] Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of...

Search for strongly coupled Chameleon scalar field with neutron interferometry

NASA Astrophysics Data System (ADS)

Li, K.; Arif, M.; Cory, D.; Haun, R.; Heacock, B.; Huber, M.; Nsofini, J.; Pushin, D. A.; Saggu, P.; Sarenac, D.; Shahi, C.; Skavysh, V.; Snow, M.; Young, A.

2015-04-01

The dark energy proposed to explain the observed accelerated expansion of the universe is not understood. A chameleon scalar field proposed as a dark energy candidate can explain the accelerated expansion and evade all current gravity experimental bounds. It features an effective range of the chameleon scalar field that depends on the local mass density. Hence a perfect crystal neutron interferometer, that measures relative phase shift between two paths, is a prefect tool to search for the chameleon field. We are preparing a two-chamber helium gas cell for the neutron interferometer. We can lower the pressure in one cell so low that the chameleon field range expands into the cell and causes a measurable neutron phase shift while keeping the pressure difference constant. We expect to set a new upper limit of the Chameleon field by at least one order of magnitude. This work is supported by NSF Grant 1205977, DOE Grant DE-FG02-97ER41042, Canadian Excellence Research Chairs program, Natural Sciences and Engineering Research Council of Canada and Collaborative Research and Training Experience Program

Triple/quadruple patterning layout decomposition via linear programming and iterative rounding

NASA Astrophysics Data System (ADS)

Lin, Yibo; Xu, Xiaoqing; Yu, Bei; Baldick, Ross; Pan, David Z.

2017-04-01

As the feature size of the semiconductor technology scales down to 10 nm and beyond, multiple patterning lithography (MPL) has become one of the most practical candidates for lithography, along with other emerging technologies, such as extreme ultraviolet lithography (EUVL), e-beam lithography (EBL), and directed self-assembly. Due to the delay of EUVL and EBL, triple and even quadruple patterning is considered to be used for lower metal and contact layers with tight pitches. In the process of MPL, layout decomposition is the key design stage, where a layout is split into various parts and each part is manufactured through a separate mask. For metal layers, stitching may be allowed to resolve conflicts, whereas it is forbidden for contact and via layers. We focus on the application of layout decomposition where stitching is not allowed, such as for contact and via layers. We propose a linear programming (LP) and iterative rounding solving technique to reduce the number of nonintegers in the LP relaxation problem. Experimental results show that the proposed algorithms can provide high quality decomposition solutions efficiently while introducing as few conflicts as possible.

Characteristics of shear damage for 60Sn-40Pb solder material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, H.E.; Chow, C.L.; Wei, Y.

This paper presents an investigation of the development of a continuum damage model capable of accurately analyzing shear damage in 60Sn-40Pb solder material. Based on the theory of damage mechanics, an internal state variable known as the damage variable is introduced to characterize material degradation caused by the change of material microstructures under load. A damage surface in stress space is proposed to quantify damage initiation and its successive expanding surfaces to represent damage hardening. With the aid of irreversible thermodynamics, the damage-coupled constitutive equations and the damage evolution equations are established. A failure criterion is proposed based on themore » accumulation of overall damage in the material. The damage model is implemented in a general purpose finite element program ABAQUS through its user-defined material subroutine UMAT. The program is applied to predict shear deformation in a notched specimen. The predicted failure mode and maximum load agree well with those measured experimentally. The effect of finite element meshing on the numerical results is also examined and discussed.« less

Numerical simulation of NQR/NMR: Applications in quantum computing.

PubMed

Possa, Denimar; Gaudio, Anderson C; Freitas, Jair C C

2011-04-01

A numerical simulation program able to simulate nuclear quadrupole resonance (NQR) as well as nuclear magnetic resonance (NMR) experiments is presented, written using the Mathematica package, aiming especially applications in quantum computing. The program makes use of the interaction picture to compute the effect of the relevant nuclear spin interactions, without any assumption about the relative size of each interaction. This makes the program flexible and versatile, being useful in a wide range of experimental situations, going from NQR (at zero or under small applied magnetic field) to high-field NMR experiments. Some conditions specifically required for quantum computing applications are implemented in the program, such as the possibility of use of elliptically polarized radiofrequency and the inclusion of first- and second-order terms in the average Hamiltonian expansion. A number of examples dealing with simple NQR and quadrupole-perturbed NMR experiments are presented, along with the proposal of experiments to create quantum pseudopure states and logic gates using NQR. The program and the various application examples are freely available through the link http://www.profanderson.net/files/nmr_nqr.php. Copyright © 2011 Elsevier Inc. All rights reserved.

Supplement Analysis for Yakima/Klickitat Fisheries Project, (DOE/EIS-0169-SA-05)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Patricia R.

2002-09-20

Yakima/Klickitat Fisheries Project – Under the Monitoring and Evaluation Program (M&E), the domestication selection research task would be modified to include a hatchery control line, maintained entirely by spawning hatchery-origin fish. The Bonneville Power Administration is funding ongoing studies, research, and artificial production of several salmonid species in the Yakima and Klickitat river basins. BPA analyzed environmental impacts of research and supplementation projects in the Yakima basin in an Environmental Impact Statement (EIS) completed in 1996 (USDOE/BPA 1996), and in the following Supplement Analyses: DOE/EIS-0169-SA-01, completed in May 1999; DOE/EIS-0169-SA-02, completed in August 1999; DOE/EIS-0169-SA-03, completed in 2000; DOE/EIS-0169-SA-04, completedmore » in November 2000. The purpose of this Supplement Analysis is to determine if a Supplemental EIS is needed to analyze the changes proposed in the Monitoring and Evaluation program (#199506325) of the Yakima Klickitat Fisheries Project (YKFP) as reviewed in the FY 2001 Project Proposals for the Columbia River Gorge and Inter-Mountain Provinces, ISRP 2000-9 (December 1, 2000). Modifications to the M&E program are in support of the experimental acclimation, rearing and incubating activities for spring chinook.« less

Game-XP: Action Games as Experimental Paradigms for Cognitive Science.

PubMed

Gray, Wayne D

2017-04-01

Why games? How could anyone consider action games an experimental paradigm for Cognitive Science? In 1973, as one of three strategies he proposed for advancing Cognitive Science, Allen Newell exhorted us to "accept a single complex task and do all of it." More specifically, he told us that rather than taking an "experimental psychology as usual approach," we should "focus on a series of experimental and theoretical studies around a single complex task" so as to demonstrate that our theories of human cognition were powerful enough to explain "a genuine slab of human behavior" with the studies fitting into a detailed theoretical picture. Action games represent the type of experimental paradigm that Newell was advocating and the current state of programming expertise and laboratory equipment, along with the emergence of Big Data and naturally occurring datasets, provide the technologies and data needed to realize his vision. Action games enable us to escape from our field's regrettable focus on novice performance to develop theories that account for the full range of expertise through a twin focus on expertise sampling (across individuals) and longitudinal studies (within individuals) of simple and complex tasks. Copyright © 2017 Cognitive Science Society, Inc.

Theoretical and experimental investigations of upper atmosphere dynamics

NASA Technical Reports Server (NTRS)

Roper, R. G.; Edwards, H. D.

1980-01-01

A brief overview of the significant contributions made to the understanding of the dynamics of the Earth's upper atmosphere is presented, including the addition of winds and diffusion to the semi-empirical Global Reference Atmospheric Model developed for the design phase of the Space Shuttle, reviews of turbulence in the lower thermosphere, the dynamics of the equatorial mesopause, stratospheric warming effects on mesopause level dynamics, and the relevance of these studies to the proposed Middle Atmosphere Program (1982-85). A chronological bibliography, with abstracts of all papers published, is also included.

Modelling of polymer photodegradation for solar cell modules

NASA Technical Reports Server (NTRS)

Somersall, A. C.; Guillet, J. E.

1981-01-01

A computer program developed to model and calculate by numerical integration the varying concentrations of chemical species formed during photooxidation of a polymeric material over time, using as input data a choice set of elementary reactions, corresponding rate constants and a convenient set of starting conditions is evaluated. Attempts were made to validate the proposed mechanism by experimentally monitoring the photooxidation products of small liquid alkane which are useful starting models for ethylene segments of polymers like EVA. The model system proved in appropriate for the intended purposes. Another validation model is recommended.

Developmental Programming of Adult Disease: Reprogramming by Melatonin?

PubMed Central

Tain, You-Lin; Huang, Li-Tung; Hsu, Chien-Ning

2017-01-01

Adult-onset chronic non-communicable diseases (NCDs) can originate from early life through so-called the “developmental origins of health and disease” (DOHaD) or “developmental programming”. The DOHaD concept offers the “reprogramming” strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evidence support that melatonin is closely inter-related to other proposed mechanisms contributing to the developmental programming of a variety of chronic NCDs. Recent animal studies have begun to unravel the multifunctional roles of melatonin in many experimental models of developmental programming. Even though some progress has been made in research on melatonin as a reprogramming strategy to prevent DOHaD-related NCDs, future human studies should aim at filling the translational gap between animal models and clinical trials. Here, we review several key themes on the reprogramming effects of melatonin in DOHaD research. We have particularly focused on the following areas: mechanisms of developmental programming; the interrelationship between melatonin and mechanisms underlying developmental programming; pathophysiological roles of melatonin in pregnancy and fetal development; and insight provided by animal models to support melatonin as a reprogramming therapy. Rates of NCDs are increasing faster than anticipated all over the world. Hence, there is an urgent need to understand reprogramming mechanisms of melatonin and to translate experimental research into clinical practice for halting a growing list of DOHaD-related NCDs. PMID:28212315

Generalized Pseudo-Reaction Zone Model for Non-Ideal Explosives

NASA Astrophysics Data System (ADS)

Wescott, Bradley

2007-06-01

The pseudo-reaction zone model was proposed to improve engineering scale simulations when using Detonation Shock Dynamics with high explosives that have a slow reaction component. In this work an extension of the pseudo-reaction zone model is developed for non-ideal explosives that propagate well below their steady-planar Chapman-Jouguet velocity. A programmed burn method utilizing Detonation Shock Dynamics and a detonation velocity dependent pseudo-reaction rate has been developed for non-ideal explosives and applied to the explosive mixture of ammonium nitrate and fuel oil (ANFO). The pseudo-reaction rate is calibrated to the experimentally obtained normal detonation velocity---shock curvature relation. The generalized pseudo-reaction zone model proposed here predicts the cylinder expansion to within 1% by accounting for the slow reaction in ANFO.

Variable geometry Darrieus wind machine

NASA Astrophysics Data System (ADS)

Pytlinski, J. T.; Serrano, D.

1983-08-01

A variable geometry Darrieus wind machine is proposed. The lower attachment of the blades to the rotor can move freely up and down the axle allowing the blades of change shape during rotation. Experimental data for a 17 m. diameter Darrieus rotor and a theoretical model for multiple streamtube performance prediction were used to develop a computer simulation program for studying parameters that affect the machine's performance. This new variable geometry concept is described and interrelated with multiple streamtube theory through aerodynamic parameters. The computer simulation study shows that governor behavior of a Darrieus turbine can not be attained by a standard turbine operating within normally occurring rotational velocity limits. A second generation variable geometry Darrieus wind turbine which uses a telescopic blade is proposed as a potential improvement on the studied concept.

Experimental apparatus for optimization of flap position for a three-element airfoil model

NASA Technical Reports Server (NTRS)

Landman, Drew

1993-01-01

It is proposed to design and build a wind tunnel model comprising a Douglas Aircraft Company three-element high-lift airfoil with internal actuators to move the flap vertically and horizontally under computer control. The model will be used to find the optimum flap location for a fixed angle of attack, slat position and flap deflection angle. The model will span the full tunnel width and lift will be measured by integration of pressure readings taken from midspan taps. It is proposed to conduct experiments in the NASA Langley EFPB 2' x 3' low speed wind tunnel. This report serves as a project overview and a review of work completed to date through funding by the 1993 NASA/ASEE Summer Faculty Fellowship Program.

L1 Adaptive Control Law for Flexible Space Launch Vehicle and Proposed Plan for Flight Test Validation

NASA Technical Reports Server (NTRS)

Kharisov, Evgeny; Gregory, Irene M.; Cao, Chengyu; Hovakimyan, Naira

2008-01-01

This paper explores application of the L1 adaptive control architecture to a generic flexible Crew Launch Vehicle (CLV). Adaptive control has the potential to improve performance and enhance safety of space vehicles that often operate in very unforgiving and occasionally highly uncertain environments. NASA s development of the next generation space launch vehicles presents an opportunity for adaptive control to contribute to improved performance of this statically unstable vehicle with low damping and low bending frequency flexible dynamics. In this paper, we consider the L1 adaptive output feedback controller to control the low frequency structural modes and propose steps to validate the adaptive controller performance utilizing one of the experimental test flights for the CLV Ares-I Program.

Highlight summarization in golf videos using audio signals

NASA Astrophysics Data System (ADS)

Kim, Hyoung-Gook; Kim, Jin Young

2008-01-01

In this paper, we present an automatic summarization of highlights in golf videos based on audio information alone without video information. The proposed highlight summarization system is carried out based on semantic audio segmentation and detection on action units from audio signals. Studio speech, field speech, music, and applause are segmented by means of sound classification. Swing is detected by the methods of impulse onset detection. Sounds like swing and applause form a complete action unit, while studio speech and music parts are used to anchor the program structure. With the advantage of highly precise detection of applause, highlights are extracted effectively. Our experimental results obtain high classification precision on 18 golf games. It proves that the proposed system is very effective and computationally efficient to apply the technology to embedded consumer electronic devices.

75 FR 7604 - Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... implement the mandatory graphic warnings required by the Tobacco Control Act. The experimental study data...] Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of... on the Experimental Study of Graphic Cigarette Warning Labels that is being conducted in support of...

Lifetime prediction and reliability estimation methodology for Stirling-type pulse tube refrigerators by gaseous contamination accelerated degradation testing

NASA Astrophysics Data System (ADS)

Wan, Fubin; Tan, Yuanyuan; Jiang, Zhenhua; Chen, Xun; Wu, Yinong; Zhao, Peng

2017-12-01

Lifetime and reliability are the two performance parameters of premium importance for modern space Stirling-type pulse tube refrigerators (SPTRs), which are required to operate in excess of 10 years. Demonstration of these parameters provides a significant challenge. This paper proposes a lifetime prediction and reliability estimation method that utilizes accelerated degradation testing (ADT) for SPTRs related to gaseous contamination failure. The method was experimentally validated via three groups of gaseous contamination ADT. First, the performance degradation model based on mechanism of contamination failure and material outgassing characteristics of SPTRs was established. Next, a preliminary test was performed to determine whether the mechanism of contamination failure of the SPTRs during ADT is consistent with normal life testing. Subsequently, the experimental program of ADT was designed for SPTRs. Then, three groups of gaseous contamination ADT were performed at elevated ambient temperatures of 40 °C, 50 °C, and 60 °C, respectively and the estimated lifetimes of the SPTRs under normal condition were obtained through acceleration model (Arrhenius model). The results show good fitting of the degradation model with the experimental data. Finally, we obtained the reliability estimation of SPTRs through using the Weibull distribution. The proposed novel methodology enables us to take less than one year time to estimate the reliability of the SPTRs designed for more than 10 years.

76 FR 71996 - Notice of Submission of Proposed Information Collection to OMB; Capacity Building for Sustainable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... Proposed Information Collection to OMB; Capacity Building for Sustainable Communities Program AGENCY... proposal. The Capacity Building for Sustainable Communities Program (Program), through a Notice of Funding...: Title of Proposal: Capacity Building for Sustainable Communities Program OMB Approval Number: 2501-0026...

Cooled variable-area radial turbine technology program

NASA Technical Reports Server (NTRS)

Large, G. D.; Meyer, L. J.

1982-01-01

The objective of this study was a conceptual evaluation and design analyses of a cooled variable-area radial turbine capable of maintaining nearly constant high efficiency when operated at a constant speed and pressure ratio over a range of flows corresponding to 50- to 100-percent maximum engine power. The results showed that a 1589K (2400 F) turbine was feasible that would satisfy a 4000-hour duty cycle life goal. The final design feasibility is based on 1988 material technology goals. A peak aerodynamic stage total efficiency of 0.88 was predicted at 100 percent power. Two candidate stators were identified: an articulated trailing-edge and a locally movable sidewall. Both concepts must be experimentally evaluated to determine the optimum configuration. A follow-on test program is proposed for this evaluation.

Photonics Xplorers and Leaders: challenging diverse students in a flat world for emerging careers

NASA Astrophysics Data System (ADS)

Hilliard-Clark, Joyce; Gilchrist, Pamela O.

2007-06-01

The Photonics programs address the question of how to integrate scientific content, student encouragement, and parental support to engage minority high school students to experience success in areas of a national need. Historical data indicates African Americans do not take advanced mathematics and science courses, especially physics, in high school. Therefore, we propose using a variety of strategies for providing instruction in leadership, experimentation, research writing, communications and scientific presentation to work with students, families and teachers in promoting selection of and academic achievement in challenging science courses. Seventy-five African American students are participating in year-round Photonics programs at The Science House on NC State University's Centennial Campus. Students from sixteen counties in North Carolina learn about fiber optics, communications and the properties of light.

Instruction-matrix-based genetic programming.

PubMed

Li, Gang; Wang, Jin Feng; Lee, Kin Hong; Leung, Kwong-Sak

2008-08-01

In genetic programming (GP), evolving tree nodes separately would reduce the huge solution space. However, tree nodes are highly interdependent with respect to their fitness. In this paper, we propose a new GP framework, namely, instruction-matrix (IM)-based GP (IMGP), to handle their interactions. IMGP maintains an IM to evolve tree nodes and subtrees separately. IMGP extracts program trees from an IM and updates the IM with the information of the extracted program trees. As the IM actually keeps most of the information of the schemata of GP and evolves the schemata directly, IMGP is effective and efficient. Our experimental results on benchmark problems have verified that IMGP is not only better than those of canonical GP in terms of the qualities of the solutions and the number of program evaluations, but they are also better than some of the related GP algorithms. IMGP can also be used to evolve programs for classification problems. The classifiers obtained have higher classification accuracies than four other GP classification algorithms on four benchmark classification problems. The testing errors are also comparable to or better than those obtained with well-known classifiers. Furthermore, an extended version, called condition matrix for rule learning, has been used successfully to handle multiclass classification problems.

A Formative-Summative Evaluation Design for a State-Sponsored Program of Educational Experimentation.

ERIC Educational Resources Information Center

Kniefel, Tanya M.

An evaluation design created to provide information for a multiple-project program of educational experimentation is presented. Project SEED (State Experimentation in Educational Development) became an official education effort in North Carolina on July 1, 1971. Model for the program was that of the State's ESEA Title III program with certain…

A novel approach for inventory problem in the pharmaceutical supply chain.

PubMed

Candan, Gökçe; Yazgan, Harun Reşit

2016-02-24

In pharmaceutical enterprises, keeping up with global market conditions is possible with properly selected supply chain management policies. Generally; demand-driven classical supply chain model is used in the pharmaceutical industry. In this study, a new mathematical model is developed to solve an inventory problem in the pharmaceutical supply chain. Unlike the studies in literature, the "shelf life and product transition times" constraints are considered, simultaneously, first time in the pharmaceutical production inventory problem. The problem is formulated as a mixed-integer linear programming (MILP) model with a hybrid time representation. The objective is to maximize total net profit. Effectiveness of the proposed model is illustrated considering a classical and a vendor managed inventory (VMI) supply chain on an experimental study. To show the effectiveness of the model, an experimental study is performed; which contains 2 different supply chain policy (Classical and VMI), 24 and 30 months planning horizon, 10 and 15 different cephalosporin products. Finally the mathematical model is compared to another model in literature and the results show that proposed model is superior. This study suggest a novel approach for solving pharmaceutical inventory problem. The developed model is maximizing total net profit while determining optimal production plan under shelf life and product transition constraints in the pharmaceutical industry. And we believe that the proposed model is much more closed to real life unlike the other studies in literature.

76 FR 62813 - Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

...] Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program Results... voluntary pilot program that enabled participating pharmaceutical firms to evaluate proposed proprietary... public meeting at the end of fiscal year 2011 to discuss the results of the pilot program, but the Agency...

Malware analysis using visualized image matrices.

PubMed

Han, KyoungSoo; Kang, BooJoong; Im, Eul Gyu

2014-01-01

This paper proposes a novel malware visual analysis method that contains not only a visualization method to convert binary files into images, but also a similarity calculation method between these images. The proposed method generates RGB-colored pixels on image matrices using the opcode sequences extracted from malware samples and calculates the similarities for the image matrices. Particularly, our proposed methods are available for packed malware samples by applying them to the execution traces extracted through dynamic analysis. When the images are generated, we can reduce the overheads by extracting the opcode sequences only from the blocks that include the instructions related to staple behaviors such as functions and application programming interface (API) calls. In addition, we propose a technique that generates a representative image for each malware family in order to reduce the number of comparisons for the classification of unknown samples and the colored pixel information in the image matrices is used to calculate the similarities between the images. Our experimental results show that the image matrices of malware can effectively be used to classify malware families both statically and dynamically with accuracy of 0.9896 and 0.9732, respectively.

Local Feature Selection for Data Classification.

PubMed

Armanfard, Narges; Reilly, James P; Komeili, Majid

2016-06-01

Typical feature selection methods choose an optimal global feature subset that is applied over all regions of the sample space. In contrast, in this paper we propose a novel localized feature selection (LFS) approach whereby each region of the sample space is associated with its own distinct optimized feature set, which may vary both in membership and size across the sample space. This allows the feature set to optimally adapt to local variations in the sample space. An associated method for measuring the similarities of a query datum to each of the respective classes is also proposed. The proposed method makes no assumptions about the underlying structure of the samples; hence the method is insensitive to the distribution of the data over the sample space. The method is efficiently formulated as a linear programming optimization problem. Furthermore, we demonstrate the method is robust against the over-fitting problem. Experimental results on eleven synthetic and real-world data sets demonstrate the viability of the formulation and the effectiveness of the proposed algorithm. In addition we show several examples where localized feature selection produces better results than a global feature selection method.

A Liquid Level Measurement Technique Outside a Sealed Metal Container Based on Ultrasonic Impedance and Echo Energy

PubMed Central

Zhang, Bin; Wei, Yue-Juan; Liu, Wen-Yi; Zhang, Yan-Jun; Yao, Zong; Zhao, Li-Hui; Xiong, Ji-Jun

2017-01-01

The proposed method for measuring the liquid level focuses on the ultrasonic impedance and echo energy inside a metal wall, to which the sensor is attached directly, not on ultrasonic waves that penetrate the gas–liquid medium of a container. Firstly, by analyzing the sound field distribution characteristics of the sensor in a metal wall, this paper proposes the concept of an "energy circle" and discusses how to calculate echo energy under three different states in detail. Meanwhile, an ultrasonic transmitting and receiving circuit is designed to convert the echo energy inside the energy circle into its equivalent electric power. Secondly, in order to find the two critical states of the energy circle in the process of liquid level detection, a program is designed to help with calculating two critical positions automatically. Finally, the proposed method is evaluated through a series of experiments, and the experimental results indicate that the proposed method is effective and accurate in calibration of the liquid level outside a sealed metal container. PMID:28106857

Model based multivariable controller for large scale compression stations. Design and experimental validation on the LHC 18KW cryorefrigerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bonne, François; Bonnay, Patrick; Alamir, Mazen

2014-01-29

In this paper, a multivariable model-based non-linear controller for Warm Compression Stations (WCS) is proposed. The strategy is to replace all the PID loops controlling the WCS with an optimally designed model-based multivariable loop. This new strategy leads to high stability and fast disturbance rejection such as those induced by a turbine or a compressor stop, a key-aspect in the case of large scale cryogenic refrigeration. The proposed control scheme can be used to have precise control of every pressure in normal operation or to stabilize and control the cryoplant under high variation of thermal loads (such as a pulsedmore » heat load expected to take place in future fusion reactors such as those expected in the cryogenic cooling systems of the International Thermonuclear Experimental Reactor ITER or the Japan Torus-60 Super Advanced fusion experiment JT-60SA). The paper details how to set the WCS model up to synthesize the Linear Quadratic Optimal feedback gain and how to use it. After preliminary tuning at CEA-Grenoble on the 400W@1.8K helium test facility, the controller has been implemented on a Schneider PLC and fully tested first on the CERN's real-time simulator. Then, it was experimentally validated on a real CERN cryoplant. The efficiency of the solution is experimentally assessed using a reasonable operating scenario of start and stop of compressors and cryogenic turbines. This work is partially supported through the European Fusion Development Agreement (EFDA) Goal Oriented Training Program, task agreement WP10-GOT-GIRO.« less

Model based multivariable controller for large scale compression stations. Design and experimental validation on the LHC 18KW cryorefrigerator

NASA Astrophysics Data System (ADS)

Bonne, François; Alamir, Mazen; Bonnay, Patrick; Bradu, Benjamin

2014-01-01

In this paper, a multivariable model-based non-linear controller for Warm Compression Stations (WCS) is proposed. The strategy is to replace all the PID loops controlling the WCS with an optimally designed model-based multivariable loop. This new strategy leads to high stability and fast disturbance rejection such as those induced by a turbine or a compressor stop, a key-aspect in the case of large scale cryogenic refrigeration. The proposed control scheme can be used to have precise control of every pressure in normal operation or to stabilize and control the cryoplant under high variation of thermal loads (such as a pulsed heat load expected to take place in future fusion reactors such as those expected in the cryogenic cooling systems of the International Thermonuclear Experimental Reactor ITER or the Japan Torus-60 Super Advanced fusion experiment JT-60SA). The paper details how to set the WCS model up to synthesize the Linear Quadratic Optimal feedback gain and how to use it. After preliminary tuning at CEA-Grenoble on the 400W@1.8K helium test facility, the controller has been implemented on a Schneider PLC and fully tested first on the CERN's real-time simulator. Then, it was experimentally validated on a real CERN cryoplant. The efficiency of the solution is experimentally assessed using a reasonable operating scenario of start and stop of compressors and cryogenic turbines. This work is partially supported through the European Fusion Development Agreement (EFDA) Goal Oriented Training Program, task agreement WP10-GOT-GIRO.

A Review of Out-of-School Time Program Quasi-Experimental and Experimental Evaluation Results. Out-of-School Time Evaluation Snapshot.

ERIC Educational Resources Information Center

Little, Priscilla M. D.; Harris, Erin

As the amount of resources allocated to out-of-school (OST) programming and policymakers' demands for research-based results increase, there is increasing interest in rigorous research designs to examine OST program outcomes. This issue of "Out-of-School Time Evaluation Snapshots" reviews 27 quasi-experimental and experimental OST…

A regression model for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.

PubMed

Wang, Bing; Shen, Hao; Fang, Aiqin; Huang, De-Shuang; Jiang, Changjun; Zhang, Jun; Chen, Peng

2016-06-17

Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC/TOF-MS) system has become a key analytical technology in high-throughput analysis. Retention index has been approved to be helpful for compound identification in one-dimensional gas chromatography, which is also true for two-dimensional gas chromatography. In this work, a novel regression model was proposed for calculating the second dimension retention index of target components where n-alkanes were used as reference compounds. This model was developed to depict the relationship among adjusted second dimension retention time, temperature of the second dimension column and carbon number of n-alkanes by an exponential nonlinear function with only five parameters. Three different criteria were introduced to find the optimal values of parameters. The performance of this model was evaluated using experimental data of n-alkanes (C7-C31) at 24 temperatures which can cover all 0-6s adjusted retention time area. The experimental results show that the mean relative error between predicted adjusted retention time and experimental data of n-alkanes was only 2%. Furthermore, our proposed model demonstrates a good extrapolation capability for predicting adjusted retention time of target compounds which located out of the range of the reference compounds in the second dimension adjusted retention time space. Our work shows the deviation was less than 9 retention index units (iu) while the number of alkanes were added up to 5. The performance of our proposed model has also been demonstrated by analyzing a mixture of compounds in temperature programmed experiments. Copyright © 2016 Elsevier B.V. All rights reserved.

A manipulative instrument with simultaneous gesture and end-effector trajectory planning and controlling

NASA Astrophysics Data System (ADS)

Lin, Hsien-I.; Nguyen, Xuan-Anh

2017-05-01

To operate a redundant manipulator to accomplish the end-effector trajectory planning and simultaneously control its gesture in online programming, incorporating the human motion is a useful and flexible option. This paper focuses on a manipulative instrument that can simultaneously control its arm gesture and end-effector trajectory via human teleoperation. The instrument can be classified by two parts; first, for the human motion capture and data processing, marker systems are proposed to capture human gesture. Second, the manipulator kinematics control is implemented by an augmented multi-tasking method, and forward and backward reaching inverse kinematics, respectively. Especially, the local-solution and divergence problems of a multi-tasking method are resolved by the proposed augmented multi-tasking method. Computer simulations and experiments with a 7-DOF (degree of freedom) redundant manipulator were used to validate the proposed method. Comparison among the single-tasking, original multi-tasking, and augmented multi-tasking algorithms were performed and the result showed that the proposed augmented method had a good end-effector position accuracy and the most similar gesture to the human gesture. Additionally, the experimental results showed that the proposed instrument was realized online.

A small Unix-based data acquisition system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engberg, D.; Glanzman, T.

1994-02-01

The proposed SLAC B Factory detector plans to use Unix-based machines for all aspects of computing, including real-time data acquisition and experimental control. A R and D program has been established to investigate the use of Unix in the various aspects of experimental computation. Earlier R and D work investigated the basic real-time aspects of the IBM RS/6000 workstation running AIX, which claims to be a real-time operating system. The next step in this R and D is the construction of a prototype data acquisition system which attempts to exercise many of the features needed in the final on-line systemmore » in a realistic situation. For this project, the authors have combined efforts with a team studying the use of novel cell designs and gas mixtures in a new prototype drift chamber.« less

Strategy Plan A Methodology to Predict the Uniformity of Double-Shell Tank Waste Slurries Based on Mixing Pump Operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.A. Bamberger; L.M. Liljegren; P.S. Lowery

This document presents an analysis of the mechanisms influencing mixing within double-shell slurry tanks. A research program to characterize mixing of slurries within tanks has been proposed. The research program presents a combined experimental and computational approach to produce correlations describing the tank slurry concentration profile (and therefore uniformity) as a function of mixer pump operating conditions. The TEMPEST computer code was used to simulate both a full-scale (prototype) and scaled (model) double-shell waste tank to predict flow patterns resulting from a stationary jet centered in the tank. The simulation results were used to evaluate flow patterns in the tankmore » and to determine whether flow patterns are similar between the full-scale prototype and an existing 1/12-scale model tank. The flow patterns were sufficiently similar to recommend conducting scoping experiments at 1/12-scale. Also, TEMPEST modeled velocity profiles of the near-floor jet were compared to experimental measurements of the near-floor jet with good agreement. Reported values of physical properties of double-shell tank slurries were analyzed to evaluate the range of properties appropriate for conducting scaled experiments. One-twelfth scale scoping experiments are recommended to confirm the prioritization of the dimensionless groups (gravitational settling, Froude, and Reynolds numbers) that affect slurry suspension in the tank. Two of the proposed 1/12-scale test conditions were modeled using the TEMPEST computer code to observe the anticipated flow fields. This information will be used to guide selection of sampling probe locations. Additional computer modeling is being conducted to model a particulate laden, rotating jet centered in the tank. The results of this modeling effort will be compared to the scaled experimental data to quantify the agreement between the code and the 1/12-scale experiment. The scoping experiment results will guide selection of parameters to be varied in the follow-on experiments. Data from the follow-on experiments will be used to develop correlations to describe slurry concentration profile as a function of mixing pump operating conditions. This data will also be used to further evaluate the computer model applications. If the agreement between the experimental data and the code predictions is good, the computer code will be recommended for use to predict slurry uniformity in the tanks under various operating conditions. If the agreement between the code predictions and experimental results is not good, the experimental data correlations will be used to predict slurry uniformity in the tanks within the range of correlation applicability.« less

Methodological convergence of program evaluation designs.

PubMed

Chacón-Moscoso, Salvador; Anguera, M Teresa; Sanduvete-Chaves, Susana; Sánchez-Martín, Milagrosa

2014-01-01

Nowadays, the confronting dichotomous view between experimental/quasi-experimental and non-experimental/ethnographic studies still exists but, despite the extensive use of non-experimental/ethnographic studies, the most systematic work on methodological quality has been developed based on experimental and quasi-experimental studies. This hinders evaluators and planners' practice of empirical program evaluation, a sphere in which the distinction between types of study is changing continually and is less clear. Based on the classical validity framework of experimental/quasi-experimental studies, we carry out a review of the literature in order to analyze the convergence of design elements in methodological quality in primary studies in systematic reviews and ethnographic research. We specify the relevant design elements that should be taken into account in order to improve validity and generalization in program evaluation practice in different methodologies from a practical methodological and complementary view. We recommend ways to improve design elements so as to enhance validity and generalization in program evaluation practice.

Efficient and Scalable Graph Similarity Joins in MapReduce

PubMed Central

Chen, Yifan; Zhang, Weiming; Tang, Jiuyang

2014-01-01

Along with the emergence of massive graph-modeled data, it is of great importance to investigate graph similarity joins due to their wide applications for multiple purposes, including data cleaning, and near duplicate detection. This paper considers graph similarity joins with edit distance constraints, which return pairs of graphs such that their edit distances are no larger than a given threshold. Leveraging the MapReduce programming model, we propose MGSJoin, a scalable algorithm following the filtering-verification framework for efficient graph similarity joins. It relies on counting overlapping graph signatures for filtering out nonpromising candidates. With the potential issue of too many key-value pairs in the filtering phase, spectral Bloom filters are introduced to reduce the number of key-value pairs. Furthermore, we integrate the multiway join strategy to boost the verification, where a MapReduce-based method is proposed for GED calculation. The superior efficiency and scalability of the proposed algorithms are demonstrated by extensive experimental results. PMID:25121135

Efficient and scalable graph similarity joins in MapReduce.

PubMed

Chen, Yifan; Zhao, Xiang; Xiao, Chuan; Zhang, Weiming; Tang, Jiuyang

2014-01-01

Along with the emergence of massive graph-modeled data, it is of great importance to investigate graph similarity joins due to their wide applications for multiple purposes, including data cleaning, and near duplicate detection. This paper considers graph similarity joins with edit distance constraints, which return pairs of graphs such that their edit distances are no larger than a given threshold. Leveraging the MapReduce programming model, we propose MGSJoin, a scalable algorithm following the filtering-verification framework for efficient graph similarity joins. It relies on counting overlapping graph signatures for filtering out nonpromising candidates. With the potential issue of too many key-value pairs in the filtering phase, spectral Bloom filters are introduced to reduce the number of key-value pairs. Furthermore, we integrate the multiway join strategy to boost the verification, where a MapReduce-based method is proposed for GED calculation. The superior efficiency and scalability of the proposed algorithms are demonstrated by extensive experimental results.

Fast and efficient search for MPEG-4 video using adjacent pixel intensity difference quantization histogram feature

NASA Astrophysics Data System (ADS)

Lee, Feifei; Kotani, Koji; Chen, Qiu; Ohmi, Tadahiro

2010-02-01

In this paper, a fast search algorithm for MPEG-4 video clips from video database is proposed. An adjacent pixel intensity difference quantization (APIDQ) histogram is utilized as the feature vector of VOP (video object plane), which had been reliably applied to human face recognition previously. Instead of fully decompressed video sequence, partially decoded data, namely DC sequence of the video object are extracted from the video sequence. Combined with active search, a temporal pruning algorithm, fast and robust video search can be realized. The proposed search algorithm has been evaluated by total 15 hours of video contained of TV programs such as drama, talk, news, etc. to search for given 200 MPEG-4 video clips which each length is 15 seconds. Experimental results show the proposed algorithm can detect the similar video clip in merely 80ms, and Equal Error Rate (ERR) of 2 % in drama and news categories are achieved, which are more accurately and robust than conventional fast video search algorithm.

Bidirectional quantum teleportation of unknown photons using path-polarization intra-particle hybrid entanglement and controlled-unitary gates via cross-Kerr nonlinearity

NASA Astrophysics Data System (ADS)

Heo, Jino; Hong, Chang-Ho; Lim, Jong-In; Yang, Hyung-Jin

2015-05-01

We propose an arbitrary controlled-unitary (CU) gate and a bidirectional quantum teleportation (BQTP) scheme. The proposed CU gate utilizes photonic qubits (photons) with cross-Kerr nonlinearities (XKNLs), X-homodyne detectors, and linear optical elements, and consists of the consecutive operation of a controlled-path (C-path) gate and a gathering-path (G-path) gate. It is almost deterministic and feasible with current technology when a strong coherent state and weak XKNLs are employed. Based on the CU gate, we present a BQTP scheme that simultaneously teleports two unknown photons between distant users by transmitting only one photon in a path-polarization intra-particle hybrid entangled state. Consequently, it is possible to experimentally implement BQTP with a certain success probability using the proposed CU gate. Project supported by the Ministry of Science, ICT&Future Planning, Korea, under the C-ITRC (Convergence Information Technology Research Center) Support program (NIPA-2013-H0301-13-3007) supervised by the National IT Industry Promotion Agency.

Improved Seam-Line Searching Algorithm for UAV Image Mosaic with Optical Flow.

PubMed

Zhang, Weilong; Guo, Bingxuan; Li, Ming; Liao, Xuan; Li, Wenzhuo

2018-04-16

Ghosting and seams are two major challenges in creating unmanned aerial vehicle (UAV) image mosaic. In response to these problems, this paper proposes an improved method for UAV image seam-line searching. First, an image matching algorithm is used to extract and match the features of adjacent images, so that they can be transformed into the same coordinate system. Then, the gray scale difference, the gradient minimum, and the optical flow value of pixels in adjacent image overlapped area in a neighborhood are calculated, which can be applied to creating an energy function for seam-line searching. Based on that, an improved dynamic programming algorithm is proposed to search the optimal seam-lines to complete the UAV image mosaic. This algorithm adopts a more adaptive energy aggregation and traversal strategy, which can find a more ideal splicing path for adjacent UAV images and avoid the ground objects better. The experimental results show that the proposed method can effectively solve the problems of ghosting and seams in the panoramic UAV images.

CUDA-based acceleration of collateral filtering in brain MR images

NASA Astrophysics Data System (ADS)

Li, Cheng-Yuan; Chang, Herng-Hua

2017-02-01

Image denoising is one of the fundamental and essential tasks within image processing. In medical imaging, finding an effective algorithm that can remove random noise in MR images is important. This paper proposes an effective noise reduction method for brain magnetic resonance (MR) images. Our approach is based on the collateral filter which is a more powerful method than the bilateral filter in many cases. However, the computation of the collateral filter algorithm is quite time-consuming. To solve this problem, we improved the collateral filter algorithm with parallel computing using GPU. We adopted CUDA, an application programming interface for GPU by NVIDIA, to accelerate the computation. Our experimental evaluation on an Intel Xeon CPU E5-2620 v3 2.40GHz with a NVIDIA Tesla K40c GPU indicated that the proposed implementation runs dramatically faster than the traditional collateral filter. We believe that the proposed framework has established a general blueprint for achieving fast and robust filtering in a wide variety of medical image denoising applications.

Design and implementation of a hybrid MPI-CUDA model for the Smith-Waterman algorithm.

PubMed

Khaled, Heba; Faheem, Hossam El Deen Mostafa; El Gohary, Rania

2015-01-01

This paper provides a novel hybrid model for solving the multiple pair-wise sequence alignment problem combining message passing interface and CUDA, the parallel computing platform and programming model invented by NVIDIA. The proposed model targets homogeneous cluster nodes equipped with similar Graphical Processing Unit (GPU) cards. The model consists of the Master Node Dispatcher (MND) and the Worker GPU Nodes (WGN). The MND distributes the workload among the cluster working nodes and then aggregates the results. The WGN performs the multiple pair-wise sequence alignments using the Smith-Waterman algorithm. We also propose a modified implementation to the Smith-Waterman algorithm based on computing the alignment matrices row-wise. The experimental results demonstrate a considerable reduction in the running time by increasing the number of the working GPU nodes. The proposed model achieved a performance of about 12 Giga cell updates per second when we tested against the SWISS-PROT protein knowledge base running on four nodes.

Forensic Uncertainty Quantification of Explosive Dispersal of Particles

NASA Astrophysics Data System (ADS)

Hughes, Kyle; Park, Chanyoung; Haftka, Raphael; Kim, Nam-Ho

2017-06-01

In addition to the numerical challenges of simulating the explosive dispersal of particles, validation of the simulation is often plagued with poor knowledge of the experimental conditions. The level of experimental detail required for validation is beyond what is usually included in the literature. This presentation proposes the use of forensic uncertainty quantification (UQ) to investigate validation-quality experiments to discover possible sources of uncertainty that may have been missed in initial design of experiments or under-reported. The current experience of the authors has found that by making an analogy to crime scene investigation when looking at validation experiments, valuable insights may be gained. One examines all the data and documentation provided by the validation experimentalists, corroborates evidence, and quantifies large sources of uncertainty a posteriori with empirical measurements. In addition, it is proposed that forensic UQ may benefit from an independent investigator to help remove possible implicit biases and increases the likelihood of discovering unrecognized uncertainty. Forensic UQ concepts will be discussed and then applied to a set of validation experiments performed at Eglin Air Force Base. This work was supported in part by the U.S. Department of Energy, National Nuclear Security Administration, Advanced Simulation and Computing Program.

Eigenvectors phase correction in inverse modal problem

NASA Astrophysics Data System (ADS)

Qiao, Guandong; Rahmatalla, Salam

2017-12-01

The solution of the inverse modal problem for the spatial parameters of mechanical and structural systems is heavily dependent on the quality of the modal parameters obtained from the experiments. While experimental and environmental noises will always exist during modal testing, the resulting modal parameters are expected to be corrupted with different levels of noise. A novel methodology is presented in this work to mitigate the errors in the eigenvectors when solving the inverse modal problem for the spatial parameters. The phases of the eigenvector component were utilized as design variables within an optimization problem that minimizes the difference between the calculated and experimental transfer functions. The equation of motion in terms of the modal and spatial parameters was used as a constraint in the optimization problem. Constraints that reserve the positive and semi-positive definiteness and the inter-connectivity of the spatial matrices were implemented using semi-definite programming. Numerical examples utilizing noisy eigenvectors with augmented Gaussian white noise of 1%, 5%, and 10% were used to demonstrate the efficacy of the proposed method. The results showed that the proposed method is superior when compared with a known method in the literature.

Stabilization of Small Boron Cage by Transition Metal Encapsulation

NASA Astrophysics Data System (ADS)

Zhang, Lijun; Lv, Jian; Wang, Yanchao; Ma, Yanming

2015-03-01

The discovery of chemically stable fullerene-like structures formed by elements other than carbon has been long-standing desired. On this aspect significant efforts have centered around boron, only one electron deficient compared with carbon. However, during the past decade a large number of experimental and theoretical studies have established that small boron clusters are either planar/quasi-planar or forming double-ring tubular structures. Until recently, two all-boron fullerenes have been independently discovered: B38 proposed by our structure searching calculations and B40 observed in a joint experimental and theoretical study. Here we extend our work to the even smaller boron clusters and propose an effective routine to stabilize them by transition metal encapsulation. By combining swarm-intelligence structure searching and first-principles calculations, we have systematically investigated the energy landscapes of transition-metal-doped MB24 clusters (M = Ti, Zr, Hf, Cr, Mo, W, Fe, Ru and Os). Two stable symmetric endohedral boron cages, MoB24 and WB24 are identified. The stability of them can be rationalized in terms of their unique 18-electron closed-shell electronic structures. Funded by Recruitment Program of Global Experts of China and China Postdoctoral Science Foundation.

Attitudes of College Freshmen in an Experimental Program.

ERIC Educational Resources Information Center

Smith, M. Daniel

This report describes the results of 2 questionnaires designed to measure students' perceptions of and satisfaction with aspects of their small liberal arts college environment. The test was administered to samples of students enrolled in the experimental program, alternates (students who had volunteered for the experimental program but were not…

Adaptive neural network motion control of manipulators with experimental evaluations.

PubMed

Puga-Guzmán, S; Moreno-Valenzuela, J; Santibáñez, V

2014-01-01

A nonlinear proportional-derivative controller plus adaptive neuronal network compensation is proposed. With the aim of estimating the desired torque, a two-layer neural network is used. Then, adaptation laws for the neural network weights are derived. Asymptotic convergence of the position and velocity tracking errors is proven, while the neural network weights are shown to be uniformly bounded. The proposed scheme has been experimentally validated in real time. These experimental evaluations were carried in two different mechanical systems: a horizontal two degrees-of-freedom robot and a vertical one degree-of-freedom arm which is affected by the gravitational force. In each one of the two experimental set-ups, the proposed scheme was implemented without and with adaptive neural network compensation. Experimental results confirmed the tracking accuracy of the proposed adaptive neural network-based controller.

Adaptive Neural Network Motion Control of Manipulators with Experimental Evaluations

PubMed Central

Puga-Guzmán, S.; Moreno-Valenzuela, J.; Santibáñez, V.

2014-01-01

A nonlinear proportional-derivative controller plus adaptive neuronal network compensation is proposed. With the aim of estimating the desired torque, a two-layer neural network is used. Then, adaptation laws for the neural network weights are derived. Asymptotic convergence of the position and velocity tracking errors is proven, while the neural network weights are shown to be uniformly bounded. The proposed scheme has been experimentally validated in real time. These experimental evaluations were carried in two different mechanical systems: a horizontal two degrees-of-freedom robot and a vertical one degree-of-freedom arm which is affected by the gravitational force. In each one of the two experimental set-ups, the proposed scheme was implemented without and with adaptive neural network compensation. Experimental results confirmed the tracking accuracy of the proposed adaptive neural network-based controller. PMID:24574910

The implementation and use of Ada on distributed systems with high reliability requirements

NASA Technical Reports Server (NTRS)

Knight, J. C.

1986-01-01

The general inadequacy of Ada for programming systems that must survive processor loss was shown. A solution to the problem was proposed in which there are no syntatic changes to Ada. The approach was evaluated using a full-scale, realistic application. The application used was the Advanced Transport Operating System (ATOPS), an experimental computer control system developed for a modified Boeing 737 aircraft. The ATOPS system is a full authority, real-time avionics system providing a large variety of advanced features. Methods of building fault tolerance into concurrent systems were explored. A set of criteria by which the proposed method will be judged was examined. Extensive interaction with personnel from Computer Sciences Corporation and NASA Langley occurred to determine the requirements of the ATOPS software. Backward error recovery in concurrent systems was assessed.

Compiler-Directed File Layout Optimization for Hierarchical Storage Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding, Wei; Zhang, Yuanrui; Kandemir, Mahmut

File layout of array data is a critical factor that effects the behavior of storage caches, and has so far taken not much attention in the context of hierarchical storage systems. The main contribution of this paper is a compiler-driven file layout optimization scheme for hierarchical storage caches. This approach, fully automated within an optimizing compiler, analyzes a multi-threaded application code and determines a file layout for each disk-resident array referenced by the code, such that the performance of the target storage cache hierarchy is maximized. We tested our approach using 16 I/O intensive application programs and compared its performancemore » against two previously proposed approaches under different cache space management schemes. Our experimental results show that the proposed approach improves the execution time of these parallel applications by 23.7% on average.« less

Compiler-Directed File Layout Optimization for Hierarchical Storage Systems

DOE PAGES

Ding, Wei; Zhang, Yuanrui; Kandemir, Mahmut; ...

2013-01-01

File layout of array data is a critical factor that effects the behavior of storage caches, and has so far taken not much attention in the context of hierarchical storage systems. The main contribution of this paper is a compiler-driven file layout optimization scheme for hierarchical storage caches. This approach, fully automated within an optimizing compiler, analyzes a multi-threaded application code and determines a file layout for each disk-resident array referenced by the code, such that the performance of the target storage cache hierarchy is maximized. We tested our approach using 16 I/O intensive application programs and compared its performancemore » against two previously proposed approaches under different cache space management schemes. Our experimental results show that the proposed approach improves the execution time of these parallel applications by 23.7% on average.« less

Noise generator for tinnitus treatment based on look-up tables

NASA Astrophysics Data System (ADS)

Uriz, Alejandro J.; Agüero, Pablo; Tulli, Juan C.; Castiñeira Moreira, Jorge; González, Esteban; Hidalgo, Roberto; Casadei, Manuel

2016-04-01

Treatment of tinnitus by means of masking sounds allows to obtain a significant improve of the quality of life of the individual that suffer that condition. In view of that, it is possible to develop noise synthesizers based on random number generators in digital signal processors (DSP), which are used in almost any digital hearing aid devices. DSP architecture have limitations to implement a pseudo random number generator, due to it, the noise statistics can be not as good as expectations. In this paper, a technique to generate additive white gaussian noise (AWGN) or other types of filtered noise using coefficients stored in program memory of the DSP is proposed. Also, an implementation of the technique is carried out on a dsPIC from Microchip®. Objective experiments and experimental measurements are performed to analyze the proposed technique.

Big data analytics for early detection of breast cancer based on machine learning

NASA Astrophysics Data System (ADS)

Ivanova, Desislava

2017-12-01

This paper presents the concept and the modern advances in personalized medicine that rely on technology and review the existing tools for early detection of breast cancer. The breast cancer types and distribution worldwide is discussed. It is spent time to explain the importance of identifying the normality and to specify the main classes in breast cancer, benign or malignant. The main purpose of the paper is to propose a conceptual model for early detection of breast cancer based on machine learning for processing and analysis of medical big dataand further knowledge discovery for personalized treatment. The proposed conceptual model is realized by using Naive Bayes classifier. The software is written in python programming language and for the experiments the Wisconsin breast cancer database is used. Finally, the experimental results are presented and discussed.

A near-optimal guidance for cooperative docking maneuvers

NASA Astrophysics Data System (ADS)

Ciarcià, Marco; Grompone, Alessio; Romano, Marcello

2014-09-01

In this work we study the problem of minimum energy docking maneuvers between two Floating Spacecraft Simulators. The maneuvers are planar and conducted autonomously in a cooperative mode. The proposed guidance strategy is based on the direct method known as Inverse Dynamics in the Virtual Domain, and the nonlinear programming solver known as Sequential Gradient-Restoration Algorithm. The combination of these methods allows for the quick prototyping of near-optimal trajectories, and results in an implementable tool for real-time closed-loop maneuvering. The experimental results included in this paper were obtained by exploiting the recently upgraded Floating Spacecraft-Simulator Testbed of the Spacecraft Robotics Laboratory at the Naval Postgraduate School. A direct performances comparison, in terms of maneuver energy and propellant mass, between the proposed guidance strategy and a LQR controller, demonstrates the effectiveness of the method.

Elevated-Confined Phase-Change Random Access Memory Cells

NASA Astrophysics Data System (ADS)

Lee; Koon, Hock; Shi; Luping; Zhao; Rong; Yang; Hongxin; Lim; Guan, Kian; Li; Jianming; Chong; Chong, Tow

2010-04-01

A new elevated-confined phase-change random access memory (PCRAM) cell structure to reduce power consumption was proposed. In this proposed structure, the confined phase-change region is sitting on top of a small metal column enclosed by a dielectric at the sides. Hence, more heat can be effectively sustained underneath the phase-change region. As for the conventional structure, the confined phase-change region is sitting directly above a large planar bottom metal electrode, which can easily conduct most of the induced heat away. From simulations, a more uniform temperature profile around the active region and a higher peak temperature at the phase-change layer (PCL) in an elevated-confined structure were observed. Experimental results showed that the elevated-confined PCRAM cell requires a lower programming power and has a better scalability than a conventional confined PCRAM cell.

A Novel Method to Determine the Hydrodynamic Coefficients of an Eyeball ROV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yh, Eng; Ws, Lau; Low, E.

2009-01-12

A good dynamics model is essential and critical for the successful design of navigation and control system of an underwater vehicle. However, it is difficult to determine from the hydrodynamic forces, the inertial added mass terms and the drag coefficients. In this paper, a new experimental method has been used to find the hydrodynamic forces for the ROV II, a remotely operated underwater vehicle. The proposed method is based on the classical free decay test, but with the spring oscillation replaced by a pendulum motion. The experiment results determined from the free decay test of a scaled model compared wellmore » with the simulation results obtained from well‐established computational fluid dynamics (CFD) program. Thus, the proposed approach can be used to find the added mass and drag coefficients for other underwater vehicles.« less

A comparison of fitness-case sampling methods for genetic programming

NASA Astrophysics Data System (ADS)

Martínez, Yuliana; Naredo, Enrique; Trujillo, Leonardo; Legrand, Pierrick; López, Uriel

2017-11-01

Genetic programming (GP) is an evolutionary computation paradigm for automatic program induction. GP has produced impressive results but it still needs to overcome some practical limitations, particularly its high computational cost, overfitting and excessive code growth. Recently, many researchers have proposed fitness-case sampling methods to overcome some of these problems, with mixed results in several limited tests. This paper presents an extensive comparative study of four fitness-case sampling methods, namely: Interleaved Sampling, Random Interleaved Sampling, Lexicase Selection and Keep-Worst Interleaved Sampling. The algorithms are compared on 11 symbolic regression problems and 11 supervised classification problems, using 10 synthetic benchmarks and 12 real-world data-sets. They are evaluated based on test performance, overfitting and average program size, comparing them with a standard GP search. Comparisons are carried out using non-parametric multigroup tests and post hoc pairwise statistical tests. The experimental results suggest that fitness-case sampling methods are particularly useful for difficult real-world symbolic regression problems, improving performance, reducing overfitting and limiting code growth. On the other hand, it seems that fitness-case sampling cannot improve upon GP performance when considering supervised binary classification.

Bag-of-features based medical image retrieval via multiple assignment and visual words weighting.

PubMed

Wang, Jingyan; Li, Yongping; Zhang, Ying; Wang, Chao; Xie, Honglan; Chen, Guoling; Gao, Xin

2011-11-01

Bag-of-features based approaches have become prominent for image retrieval and image classification tasks in the past decade. Such methods represent an image as a collection of local features, such as image patches and key points with scale invariant feature transform (SIFT) descriptors. To improve the bag-of-features methods, we first model the assignments of local descriptors as contribution functions, and then propose a novel multiple assignment strategy. Assuming the local features can be reconstructed by their neighboring visual words in a vocabulary, reconstruction weights can be solved by quadratic programming. The weights are then used to build contribution functions, resulting in a novel assignment method, called quadratic programming (QP) assignment. We further propose a novel visual word weighting method. The discriminative power of each visual word is analyzed by the sub-similarity function in the bin that corresponds to the visual word. Each sub-similarity function is then treated as a weak classifier. A strong classifier is learned by boosting methods that combine those weak classifiers. The weighting factors of the visual words are learned accordingly. We evaluate the proposed methods on medical image retrieval tasks. The methods are tested on three well-known data sets, i.e., the ImageCLEFmed data set, the 304 CT Set, and the basal-cell carcinoma image set. Experimental results demonstrate that the proposed QP assignment outperforms the traditional nearest neighbor assignment, the multiple assignment, and the soft assignment, whereas the proposed boosting based weighting strategy outperforms the state-of-the-art weighting methods, such as the term frequency weights and the term frequency-inverse document frequency weights.

Transcriptional Basis of Drought-Induced Susceptibility to the Rice Blast Fungus Magnaporthe oryzae

PubMed Central

Bidzinski, Przemyslaw; Ballini, Elsa; Ducasse, Aurélie; Michel, Corinne; Zuluaga, Paola; Genga, Annamaria; Chiozzotto, Remo; Morel, Jean-Benoit

2016-01-01

Plants are often facing several stresses simultaneously. Understanding how they react and the way pathogens adapt to such combinational stresses is poorly documented. Here, we developed an experimental system mimicking field intermittent drought on rice followed by inoculation by the pathogenic fungus Magnaporthe oryzae. This experimental system triggers an enhancement of susceptibility that could be correlated with the dampening of several aspects of plant immunity, namely the oxidative burst and the transcription of several pathogenesis-related genes. Quite strikingly, the analysis of fungal transcription by RNASeq analysis under drought reveals that the fungus is greatly modifying its virulence program: genes coding for small secreted proteins were massively repressed in droughted plants compared to unstressed ones whereas genes coding for enzymes involved in degradation of cell-wall were induced. We also show that drought can lead to the partial breakdown of several major resistance genes by affecting R plant gene and/or pathogen effector expression. We propose a model where a yet unknown plant signal can trigger a change in the virulence program of the pathogen to adapt to a plant host that was affected by drought prior to infection. PMID:27833621

Orion Launch Abort Vehicle Attitude Control Motor Testing

NASA Technical Reports Server (NTRS)

Murphy, Kelly J.; Brauckmann, Gregory J.; Paschal, Keith B.; Chan, David T.; Walker, Eric L.; Foley, Robert; Mayfield, David; Cross, Jared

2011-01-01

Current Orion Launch Abort Vehicle (LAV) configurations use an eight-jet, solid-fueled Attitude Control Motor (ACM) to provide required vehicle control for all proposed abort trajectories. Due to the forward position of the ACM on the LAV, it is necessary to assess the effects of jet-interactions (JI) between the various ACM nozzle plumes and the external flow along the outside surfaces of the vehicle. These JI-induced changes in flight control characteristics must be accounted for in developing ACM operations and LAV flight characteristics. A test program to generate jet interaction aerodynamic increment data for multiple LAV configurations was conducted in the NASA Ames and NASA Langley Unitary Plan Wind Tunnels from August 2007 through December 2009. Using cold air as the simulant gas, powered subscale models were used to generate interaction data at subsonic, transonic, and supersonic test conditions. This paper presents an overview of the complete ACM JI experimental test program for Orion LAV configurations, highlighting ACM system modeling, nozzle scaling assumptions, experimental test techniques, and data reduction methodologies. Lessons learned are discussed, and sample jet interaction data are shown. These data, in conjunction with computational predictions, were used to create the ACM JI increments for all relevant flight databases.

Using Genetic Programming with Prior Formula Knowledge to Solve Symbolic Regression Problem.

PubMed

Lu, Qiang; Ren, Jun; Wang, Zhiguang

2016-01-01

A researcher can infer mathematical expressions of functions quickly by using his professional knowledge (called Prior Knowledge). But the results he finds may be biased and restricted to his research field due to limitation of his knowledge. In contrast, Genetic Programming method can discover fitted mathematical expressions from the huge search space through running evolutionary algorithms. And its results can be generalized to accommodate different fields of knowledge. However, since GP has to search a huge space, its speed of finding the results is rather slow. Therefore, in this paper, a framework of connection between Prior Formula Knowledge and GP (PFK-GP) is proposed to reduce the space of GP searching. The PFK is built based on the Deep Belief Network (DBN) which can identify candidate formulas that are consistent with the features of experimental data. By using these candidate formulas as the seed of a randomly generated population, PFK-GP finds the right formulas quickly by exploring the search space of data features. We have compared PFK-GP with Pareto GP on regression of eight benchmark problems. The experimental results confirm that the PFK-GP can reduce the search space and obtain the significant improvement in the quality of SR.

Water NSTF Design, Instrumentation, and Test Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lisowski, Darius D.; Gerardi, Craig D.; Hu, Rui

The following report serves as a formal introduction to the water-based Natural convection Shutdown heat removal Test Facility (NSTF) program at Argonne. Since 2005, this US Department of Energy (DOE) sponsored program has conducted large scale experimental testing to generate high-quality and traceable validation data for guiding design decisions of the Reactor Cavity Cooling System (RCCS) concept for advanced reactor designs. The most recent facility iteration, and focus of this report, is the operation of a 1/2 scale model of a water-RCCS concept. Several features of the NSTF prototype align with the conceptual design that has been publicly released formore » the AREVA 625 MWt SC-HTGR. The design of the NSTF also retains all aspects common to a fundamental boiling water thermosiphon, and thus is well poised to provide necessary experimental data to advance basic understanding of natural circulation phenomena and contribute to computer code validation. Overall, the NSTF program operates to support the DOE vision of aiding US vendors in design choices of future reactor concepts, advancing the maturity of codes for licensing, and ultimately developing safe and reliable reactor technologies. In this report, the top-level program objectives, testing requirements, and unique considerations for the water cooled test assembly are discussed, and presented in sufficient depth to support defining the program’s overall scope and purpose. A discussion of the proposed 6-year testing program is then introduced, which outlines the specific strategy and testing plan for facility operations. The proposed testing plan has been developed to meet the toplevel objective of conducting high-quality test operations that span across a broad range of single- and two-phase operating conditions. Details of characterization, baseline test cases, accident scenario, and parametric variations are provided, including discussions of later-stage test cases that examine the influence of geometric variations and off-normal configurations. The facility design follows, including as-built dimensions and specifications of the various mechanical and liquid systems, design choices for the test section, water storage tank, and network piping. Specifications of the instrumentation suite are then presented, along with specific information on performance windows, measurement uncertainties, and installation locations. Finally, descriptions of the control systems and heat removal networks are provided, which have been engineered to support precise quantification of energy balances and facilitate well-controlled test operations.« less

Mothers’ Employment and Health of Low-Income Children

PubMed Central

Gennetian, Lisa; Hill, Heather; Lopoo, Leonard; London, Andrew

2010-01-01

This study examines whether maternal employment affects the health status of low-income, elementary-school-aged children using instrumental variables estimation and experimental data from a welfare-to-work program implemented in the early 1990s. Mother’s report of child health status is predicted as a function of exogenous variation in maternal employment associated with random assignment to the program group. IV estimates show a modest adverse effect of maternal employment on children’s health. Making use of data from another welfare-to-work program we propose that any adverse effect on child health may be tempered by increased family income and access to public health insurance coverage, findings with direct relevance to a number of current policy discussions. In a secondary analysis using fixed effects techniques on longitudinal survey data collected in 1998 and 2001, we find a comparable adverse effect of maternal employment on child health that supports the external validity of our primary result. PMID:20356641

76 FR 76422 - Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

...] Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study on Comparing Data Obtained From Landline Telephone and Cell Phone Surveys AGENCY: Food and Drug Administration... notice. This notice solicits comments on a study entitled ``Experimental Study on Comparing Data Obtained...

Photonic Programmable Tele-Cloning Network.

PubMed

Li, Wei; Chen, Ming-Cheng

2016-06-29

The concept of quantum teleportation allows an unknown quantum states to be broadcasted and processed in a distributed quantum network. The quantum information injected into the network can be diluted to distant multi-copies by quantum cloning and processed by arbitrary quantum logic gates which were programed in advance in the network quantum state. A quantum network combines simultaneously these fundamental quantum functions could lead to new intriguing applications. Here we propose a photonic programmable telecloning network based on a four-photon interferometer. The photonic network serves as quantum gate, quantum cloning and quantum teleportation and features experimental advantage of high brightness by photon recycling.

Highly Loaded Composite Strut Test Development

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey; Phelps, James E.; McKenney, Martin J.; Jegley, Dawn C.

2011-01-01

Highly loaded composite struts, representative of structural elements of a proposed truss-based lunar lander descent stage concept, were selected for design, development, fabrication and testing under NASA s Advanced Composites Technology program. The focus of this paper is the development of a capability for experimental evaluation of the structural performance of these struts. Strut lengths range from 60 to over 120 inches, and compressive launch and ascent loads can exceed -100,000 lbs, or approximately two times the corresponding tensile loads. Allowing all possible compressive structural responses, including elastic buckling, were primary considerations for designing the test hardware.

The 30/20 GHz communications system functional requirements

NASA Technical Reports Server (NTRS)

Siperko, C. M.; Frankfort, M.; Markham, R.; Wall, M.

1981-01-01

The characteristics of 30/20 GHz usage in satellite systems to be used in support of projected communication requirements of the 1990's are defined. A requirements analysis which develops projected market demand for satellite services by general and specialized carriers and an analysis of the impact of propagation and system constraints on 30/20 GHz operation are included. A set of technical performance characteristics for the 30/20 GHz systems which can serve the resulting market demand and the experimental program necessary to verify technical and operational aspects of the proposed systems is also discussed.

A network thermodynamic method for numerical solution of the Nernst-Planck and Poisson equation system with application to ionic transport through membranes.

PubMed

Horno, J; González-Caballero, F; González-Fernández, C F

1990-01-01

Simple techniques of network thermodynamics are used to obtain the numerical solution of the Nernst-Planck and Poisson equation system. A network model for a particular physical situation, namely ionic transport through a thin membrane with simultaneous diffusion, convection and electric current, is proposed. Concentration and electric field profiles across the membrane, as well as diffusion potential, have been simulated using the electric circuit simulation program, SPICE. The method is quite general and extremely efficient, permitting treatments of multi-ion systems whatever the boundary and experimental conditions may be.

Parallelized seeded region growing using CUDA.

PubMed

Park, Seongjin; Lee, Jeongjin; Lee, Hyunna; Shin, Juneseuk; Seo, Jinwook; Lee, Kyoung Ho; Shin, Yeong-Gil; Kim, Bohyoung

2014-01-01

This paper presents a novel method for parallelizing the seeded region growing (SRG) algorithm using Compute Unified Device Architecture (CUDA) technology, with intention to overcome the theoretical weakness of SRG algorithm of its computation time being directly proportional to the size of a segmented region. The segmentation performance of the proposed CUDA-based SRG is compared with SRG implementations on single-core CPUs, quad-core CPUs, and shader language programming, using synthetic datasets and 20 body CT scans. Based on the experimental results, the CUDA-based SRG outperforms the other three implementations, advocating that it can substantially assist the segmentation during massive CT screening tests.

Harsh Environment Silicon Carbide Sensor Technology for Geothermal Instrumentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pisano, Albert P.

2013-04-26

This project utilizes Silicon Carbide (SiC) materials platform to fabricate advanced sensors to be used as high-temperature downhole instrumentation for the DOE’s Geothermal Technologies Program on Enhanced Geothermal Systems. The scope of the proposed research is to 1) develop a SiC pressure sensor that can operate in harsh supercritical conditions, 2) develop a SiC temperature sensor that can operate in harsh supercritical conditions, 3) develop a bonding process for adhering SiC sensor die to well casing couplers, and 4) perform experimental exposure testing of sensor materials and the sensor devices.

Mathematical Modeling in Systems for Operational Evaluation of the Stress-Strain State of the Arch-Gravity Dam at the Sayano-Shushenskaya Hydroelectric Power Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bellendir, E. N.; Gordon, L. A., E-mail: lev-gordon@mail.ru; Khrapkov, A. A.

Current studies of the stress-strain state of the dam at the Sayano-Shushenskaya Hydroelectric Power Plant at VNIIG based on mathematical modeling including full scale and experimental data are described. Applications and programs intended for automatic operational evaluation of the stress-strain state of the dam for optimizing control of the upper race level in the course of the annual filling-drawdown cycle and during seismic events are examined. Improvements in systems for monitoring the stress-strain state of concrete dams are proposed.

Effects of two different programs of modern sports dancing on motor coordination, strength, and speed.

PubMed

Uzunovic, Slavoljub; Kostic, Radmila; Zivkovic, Dobrica

2010-09-01

This study aimed to determine the effects of two different programs of modern sports dancing on coordination, strength, and speed in 60 beginner-level female dancers, aged 13 and 14 yrs. The subjects were divided into two experimental groups (E1 and E2), each numbering 30 subjects, drawn from local dance clubs. In order to determine motor coordination, strength, and speed, we used 15 measurements. The groups were tested before and after the experimental programs. Both experimental programs lasted for 18 wks, with training sessions twice a week for 60 minutes. The subjects from the E1 group trained according to a new experimental program of disco dance (DD) modern sports dance, and the E2 group trained according to the classic DD program of the same kind for beginner selections. The obtained results were assessed by statistical analysis: a paired-samples t-test and MANCOVA/ANCOVA. The results indicated that following the experimental programs, both groups showed a statistically significant improvement in the evaluated skills, but the changes among the E1 group subjects were more pronounced. The basic assumption of this research was confirmed, that the new experimental DD program has a significant influence on coordination, strength, and speed. In relation to these changes, the application of the new DD program was recommended for beginner dancers.

Microfluidic System Simulation Including the Electro-Viscous Effect

NASA Technical Reports Server (NTRS)

Rojas, Eileen; Chen, C. P.; Majumdar, Alok

2007-01-01

This paper describes a practical approach using a general purpose lumped-parameter computer program, GFSSP (Generalized Fluid System Simulation Program) for calculating flow distribution in a network of micro-channels including electro-viscous effects due to the existence of electrical double layer (EDL). In this study, an empirical formulation for calculating an effective viscosity of ionic solutions based on dimensional analysis is described to account for surface charge and bulk fluid conductivity, which give rise to electro-viscous effect in microfluidics network. Two dimensional slit micro flow data was used to determine the model coefficients. Geometry effect is then included through a Poiseuille number correlation in GFSSP. The bi-power model was used to calculate flow distribution of isotropically etched straight channel and T-junction microflows involving ionic solutions. Performance of the proposed model is assessed against experimental test data.

Designing, programming, and optimizing a (small) quantum computer

NASA Astrophysics Data System (ADS)

Svore, Krysta

In 1982, Richard Feynman proposed to use a computer founded on the laws of quantum physics to simulate physical systems. In the more than thirty years since, quantum computers have shown promise to solve problems in number theory, chemistry, and materials science that would otherwise take longer than the lifetime of the universe to solve on an exascale classical machine. The practical realization of a quantum computer requires understanding and manipulating subtle quantum states while experimentally controlling quantum interference. It also requires an end-to-end software architecture for programming, optimizing, and implementing a quantum algorithm on the quantum device hardware. In this talk, we will introduce recent advances in connecting abstract theory to present-day real-world applications through software. We will highlight recent advancement of quantum algorithms and the challenges in ultimately performing a scalable solution on a quantum device.

Cryogenic fluid management (base R/T): Cryogenic fluid systems, Cryogenic Orbital Nitrogen Experiment (CONE), Cryogenic Orbital Hydrogen Experiment (COHE). (Transportation focused technology)

NASA Technical Reports Server (NTRS)

Symons, Pat

1991-01-01

The topics presented are covered in viewgraph form. The concluded remarks are: (1) advanced cryogenic fluid systems technology is enhancing or enabling to all known transportation scenarios for space exploration; (2) an integrated/coordinated program involving LeRC/MSFC has been formulated to address all known CFM needs - new needs should they develop, can be accommodated within available skills/facilities; (3) all required/experienced personnel and facilities are finally in place - data from initial ground-based experiments is being collected and analyzed - small scale STS experiments are nearing flight - program is beginning to yield significant results; (4) future proposed funding to primarily come from two sources; and (5) cryogenic fluid experimentation is essential to provide required technology and assure implementation in future NASA missions.

The Electric Insertion Transfer Experiment (ELITE) - An Air Force critical experiment to revolutionize space transportation

NASA Astrophysics Data System (ADS)

Matlock, Richard S.; Feig, Jason R.; Dickey, Michael R.

A program called the Electric Insertion Transfer Experiment or ELITE for demonstrating the use of solar-electric propulsion is proposed and described. The ELITE concept is based on the use of solar propulsion for the orbit-raising mode of an electric orbital-transfer vehicle (EOTV) and examines issues associated with electric thrusters. Experimental subsystems are compared including arcjet, ion, and magnetoplasmadynamic thrusters, and the design and performance impacts on EOTVs are listed. The ELITE experiment is shown to be capable of studying such issues as the plume-to-plume interaction of multiple thrusters, the contamination of spacecraft components, potential interferences from radio-frequency transmissions, and the charging of spacecraft surfaces. Solar propulsion can be studied within the context of the ELITE program to demonstrate its potential as both enhancing and enabling technology.

Business grants

NASA Astrophysics Data System (ADS)

Twelve small businesses who are developing equipment and computer programs for geophysics have won Small Business Innovative Research (SBIR) grants from the National Science Foundation for their 1989 proposals. The SBIR program was set up to encourage the private sector to undertake costly, advanced experimental work that has potential for great benefit.The geophysical research projects are a long-path intracavity laser spectrometer for measuring atmospheric trace gases, optimizing a local weather forecast model, a new platform for high-altitude atmospheric science, an advanced density logging tool, a deep-Earth sampling system, superconducting seismometers, a phased-array Doppler current profiler, monitoring mesoscale surface features of the ocean through automated analysis, krypton-81 dating in polar ice samples, discrete stochastic modeling of thunderstorm winds, a layered soil-synthetic liner base system to isolate buildings from earthquakes, and a low-cost continuous on-line organic-content monitor for water-quality determination.

75 FR 6131 - Proposed Processed Raspberry Promotion, Research, and Information Order

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... promotion, research, and information program for processed raspberries. The proposed program, Processed... be exempt from the assessment. The proposed program would be implemented under the Commodity... implementation of the program prior to it going into effect. In addition, USDA is announcing that the referendum...

Practical application of computer programs for supersonic combustion

NASA Technical Reports Server (NTRS)

Groves, F. R., Jr.

1972-01-01

Experimental data were interpreted using two supersonic combustion computer programs. The P1 program is based on a conventional boundary layer treatment of the mixing of concentric gas streams and complete combustion chemistry. The H1 program is based on a modified boundary layer approach which accounts for radial pressure gradients in the flow and also incorporates a finite rate chemistry calculation. The objective of the investigation was to compare the experimental data with theoretical predictions of the two programs with special emphasis on the prediction of radial pressure gradients by the H1 program. A test of the H1 program was also desired through comparison with the experimental data and with the P1 program.

Triple/quadruple patterning layout decomposition via novel linear programming and iterative rounding

NASA Astrophysics Data System (ADS)

Lin, Yibo; Xu, Xiaoqing; Yu, Bei; Baldick, Ross; Pan, David Z.

2016-03-01

As feature size of the semiconductor technology scales down to 10nm and beyond, multiple patterning lithography (MPL) has become one of the most practical candidates for lithography, along with other emerging technologies such as extreme ultraviolet lithography (EUVL), e-beam lithography (EBL) and directed self assembly (DSA). Due to the delay of EUVL and EBL, triple and even quadruple patterning are considered to be used for lower metal and contact layers with tight pitches. In the process of MPL, layout decomposition is the key design stage, where a layout is split into various parts and each part is manufactured through a separate mask. For metal layers, stitching may be allowed to resolve conflicts, while it is forbidden for contact and via layers. In this paper, we focus on the application of layout decomposition where stitching is not allowed such as for contact and via layers. We propose a linear programming and iterative rounding (LPIR) solving technique to reduce the number of non-integers in the LP relaxation problem. Experimental results show that the proposed algorithms can provide high quality decomposition solutions efficiently while introducing as few conflicts as possible.

Prediction of essential proteins based on gene expression programming.

PubMed

Zhong, Jiancheng; Wang, Jianxin; Peng, Wei; Zhang, Zhen; Pan, Yi

2013-01-01

Essential proteins are indispensable for cell survive. Identifying essential proteins is very important for improving our understanding the way of a cell working. There are various types of features related to the essentiality of proteins. Many methods have been proposed to combine some of them to predict essential proteins. However, it is still a big challenge for designing an effective method to predict them by integrating different features, and explaining how these selected features decide the essentiality of protein. Gene expression programming (GEP) is a learning algorithm and what it learns specifically is about relationships between variables in sets of data and then builds models to explain these relationships. In this work, we propose a GEP-based method to predict essential protein by combing some biological features and topological features. We carry out experiments on S. cerevisiae data. The experimental results show that the our method achieves better prediction performance than those methods using individual features. Moreover, our method outperforms some machine learning methods and performs as well as a method which is obtained by combining the outputs of eight machine learning methods. The accuracy of predicting essential proteins can been improved by using GEP method to combine some topological features and biological features.

78 FR 4156 - Notice of Proposed Information Collection: Comment Request; Assisted Living Conversion Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... Information Collection: Comment Request; Assisted Living Conversion Program (ALCP) for Eligible Multifamily.... This Notice also lists the following information: Title of Proposal: Assisted Living Conversion Program.... Description of the need for the information and proposed use: The Assisted Living Conversion Program and the...

Multi-task linear programming discriminant analysis for the identification of progressive MCI individuals.

PubMed

Yu, Guan; Liu, Yufeng; Thung, Kim-Han; Shen, Dinggang

2014-01-01

Accurately identifying mild cognitive impairment (MCI) individuals who will progress to Alzheimer's disease (AD) is very important for making early interventions. Many classification methods focus on integrating multiple imaging modalities such as magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). However, the main challenge for MCI classification using multiple imaging modalities is the existence of a lot of missing data in many subjects. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, almost half of the subjects do not have PET images. In this paper, we propose a new and flexible binary classification method, namely Multi-task Linear Programming Discriminant (MLPD) analysis, for the incomplete multi-source feature learning. Specifically, we decompose the classification problem into different classification tasks, i.e., one for each combination of available data sources. To solve all different classification tasks jointly, our proposed MLPD method links them together by constraining them to achieve the similar estimated mean difference between the two classes (under classification) for those shared features. Compared with the state-of-the-art incomplete Multi-Source Feature (iMSF) learning method, instead of constraining different classification tasks to choose a common feature subset for those shared features, MLPD can flexibly and adaptively choose different feature subsets for different classification tasks. Furthermore, our proposed MLPD method can be efficiently implemented by linear programming. To validate our MLPD method, we perform experiments on the ADNI baseline dataset with the incomplete MRI and PET images from 167 progressive MCI (pMCI) subjects and 226 stable MCI (sMCI) subjects. We further compared our method with the iMSF method (using incomplete MRI and PET images) and also the single-task classification method (using only MRI or only subjects with both MRI and PET images). Experimental results show very promising performance of our proposed MLPD method.

Multi-Task Linear Programming Discriminant Analysis for the Identification of Progressive MCI Individuals

PubMed Central

Yu, Guan; Liu, Yufeng; Thung, Kim-Han; Shen, Dinggang

2014-01-01

Accurately identifying mild cognitive impairment (MCI) individuals who will progress to Alzheimer's disease (AD) is very important for making early interventions. Many classification methods focus on integrating multiple imaging modalities such as magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). However, the main challenge for MCI classification using multiple imaging modalities is the existence of a lot of missing data in many subjects. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, almost half of the subjects do not have PET images. In this paper, we propose a new and flexible binary classification method, namely Multi-task Linear Programming Discriminant (MLPD) analysis, for the incomplete multi-source feature learning. Specifically, we decompose the classification problem into different classification tasks, i.e., one for each combination of available data sources. To solve all different classification tasks jointly, our proposed MLPD method links them together by constraining them to achieve the similar estimated mean difference between the two classes (under classification) for those shared features. Compared with the state-of-the-art incomplete Multi-Source Feature (iMSF) learning method, instead of constraining different classification tasks to choose a common feature subset for those shared features, MLPD can flexibly and adaptively choose different feature subsets for different classification tasks. Furthermore, our proposed MLPD method can be efficiently implemented by linear programming. To validate our MLPD method, we perform experiments on the ADNI baseline dataset with the incomplete MRI and PET images from 167 progressive MCI (pMCI) subjects and 226 stable MCI (sMCI) subjects. We further compared our method with the iMSF method (using incomplete MRI and PET images) and also the single-task classification method (using only MRI or only subjects with both MRI and PET images). Experimental results show very promising performance of our proposed MLPD method. PMID:24820966

FY 1998 Proposed Rail Improvement Program Supplement

DOT National Transportation Integrated Search

1997-01-01

This FY 1998 Proposed Rail Improvement Program Supplement contains those rail plan amendments which have been published subsequent to the FY 1997 Proposed Rail Improvement program supplement. This document also contains the benefit/cost methodology u...

Progressive collapse of a two-story reinforced concrete frame with embedded smart aggregates

NASA Astrophysics Data System (ADS)

Laskar, Arghadeep; Gu, Haichang; Mo, Y. L.; Song, Gangbing

2009-07-01

This paper reports the experimental and analytical results of a two-story reinforced concrete frame instrumented with innovative piezoceramic-based smart aggregates (SAs) and subjected to a monotonic lateral load up to failure. A finite element model of the frame is developed and analyzed using a computer program called Open system for earthquake engineering simulation (OpenSees). The finite element analysis (FEA) is used to predict the load-deformation curve as well as the development of plastic hinges in the frame. The load-deformation curve predicted from FEA matched well with the experimental results. The sequence of development of plastic hinges in the frame is also studied from the FEA results. The locations of the plastic hinges, as obtained from the analysis, were similar to those observed during the experiment. An SA-based approach is also proposed to evaluate the health status of the concrete frame and identify the development of plastic hinges during the loading procedure. The results of the FEA are used to validate the SA-based approach for detecting the locations and occurrence of the plastic hinges leading to the progressive collapse of the frame. The locations and sequential development of the plastic hinges obtained from the SA-based approach corresponds well with the FEA results. The proposed SA-based approach, thus validated using FEA and experimental results, has a great potential to be applied in the health monitoring of large-scale civil infrastructures.

BossPro: a biometrics-based obfuscation scheme for software protection

NASA Astrophysics Data System (ADS)

Kuseler, Torben; Lami, Ihsan A.; Al-Assam, Hisham

2013-05-01

This paper proposes to integrate biometric-based key generation into an obfuscated interpretation algorithm to protect authentication application software from illegitimate use or reverse-engineering. This is especially necessary for mCommerce because application programmes on mobile devices, such as Smartphones and Tablet-PCs are typically open for misuse by hackers. Therefore, the scheme proposed in this paper ensures that a correct interpretation / execution of the obfuscated program code of the authentication application requires a valid biometric generated key of the actual person to be authenticated, in real-time. Without this key, the real semantics of the program cannot be understood by an attacker even if he/she gains access to this application code. Furthermore, the security provided by this scheme can be a vital aspect in protecting any application running on mobile devices that are increasingly used to perform business/financial or other security related applications, but are easily lost or stolen. The scheme starts by creating a personalised copy of any application based on the biometric key generated during an enrolment process with the authenticator as well as a nuance created at the time of communication between the client and the authenticator. The obfuscated code is then shipped to the client's mobile devise and integrated with real-time biometric extracted data of the client to form the unlocking key during execution. The novelty of this scheme is achieved by the close binding of this application program to the biometric key of the client, thus making this application unusable for others. Trials and experimental results on biometric key generation, based on client's faces, and an implemented scheme prototype, based on the Android emulator, prove the concept and novelty of this proposed scheme.

Recent Results of NASA's Space Environments and Effects Program

NASA Technical Reports Server (NTRS)

Minor, Jody L.; Brewer, Dana S.

1998-01-01

The Space Environments and Effects (SEE) Program is a multi-center multi-agency program managed by the NASA Marshall Space Flight Center. The program evolved from the Long Duration Exposure Facility (LDEF), analysis of LDEF data, and recognition of the importance of the environments and environmental effects on future space missions. It is a very comprehensive and focused approach to understanding the space environments, to define the best techniques for both flight and ground-based experimentation, to update the models which predict both the environments and the environmental effects on spacecraft, and finally to ensure that this information is properly maintained and inserted into spacecraft design programs. Formal funding of the SEE Program began initially in FY95. A NASA Research Announcement (NRA) solicited research proposals in the following categories: 1) Engineering environment definitions; 2) Environments and effects design guidelines; 3) Environments and effects assessment models and databases; and, 4) Flight/ground simulation/technology assessment data. This solicitation resulted in funding for eighteen technology development activities (TDA's). This paper will present and describe technical results rom the first set of TDA's of the SEE Program. It will also describe the second set of technology development activities which are expected to begin in January 1998. These new technology development activities will enable the SEE Program to start numerous new development activities in support of mission customer needs.

Experimental and finite element investigation of the buckling characteristics of a beaded skin panel for a hypersonic aircraft. Ph.D. Thesis. Final Report

NASA Technical Reports Server (NTRS)

Siegel, W. H.

1978-01-01

As part of NASA's continuing research into hypersonics and 85 square foot hypersonic wing test section of a proposed hypersonic research airplane was laboratory tested. The project reported on in this paper has carried the hypersonic wing test structure project one step further by testing a single beaded panel to failure. The primary interest was focused upon the buckling characteristics of the panel under pure compression with boundary conditions similar to those found in a wing mounted condition. Three primary phases of analysis are included in the report. These phases include: experimental testing of the beaded panel to failure; finite element structural analysis of the beaded panel with the computer program NASTRAN; a summary of the semiclassical buckling equations for the beaded panel under purely compressive loads. Comparisons between each of the analysis methods are also included.

Ultrafast Dynamics in DNA and RNA Derivatives Monitored by Broadband Transient Absorption Spectrscopy

NASA Astrophysics Data System (ADS)

Brister, Matthew M.; Crespo-Hernández, Carlos E.

2015-06-01

The ultrafast dynamics of nucleic acids have been under scrutiny for the past couple of decades because of the role that the high-energy electronic states play in mutagenesis and carcinogenesis. Kinetic models have been proposed, based on both experimental and theoretical discoveries. Direct experimental evidence of the intersystem crossing rate and population of the triplet state for most nucleic acid bases has yet to be reported, even though the triplet state is thought to be the most reactive species. Utilizing broadband femtosecond transient absorption spectroscopy, we reveal the time scale at which singlet-to-triplet population transfer occurs in several nucleic acid derivatives in the condensed phase. The implication of these results to the current understanding of the DNA and RNA photochemistry will be discussed. The authors acknowledge the CAREER program of the National Science Foundation (Grant No. CHE-1255084) for financial support.

Experimental study and modelling of deuterium thermal release from Be-D co-deposited layers

NASA Astrophysics Data System (ADS)

Baldwin, M. J.; Schwarz-Selinger, T.; Doerner, R. P.

2014-07-01

A study of the thermal desorption of deuterium from 1 µm thick co-deposited Be-(0.1)D layers formed at 330 K by a magnetron sputtering technique is reported. A range of thermal desorption rates 0 ⩽ β ⩽ 1.0 K s-1 are explored with a view to studying the effectiveness of the proposed ITER wall and divertor bake procedure (β = 0 K s-1) to be carried out at 513 and 623 K. Fixed temperature bake durations up to 24 h are examined. The experimental thermal release data are used to validate a model input into the Tritium Migration and Analysis Program (TMAP-7). Good agreement with experiment is observed for a TMAP-7 model incorporating trap populations of activation energies for D release of 0.80 and 0.98 eV, and a dynamically computed surface D atomic to molecular recombination rate.

A feasibility study of developing toroidal tanks for a spinning spacecraft. Part 2: Evaluation of fluid behavior in spinning toroidal tanks

NASA Technical Reports Server (NTRS)

Anderson, J. E.

1974-01-01

An experimental program was conducted for the purpose of evaluating propellant behavior characteristics in spinning toroidal tanks. The effects of typical mission requirements, and related phenomena upon propellant slosh and settling, and orientation and stability of the ullage were investigated in a subscale model tank under both one-g and low-g acceleration environments. Specific conditions included were axial acceleration, spin rate, spinrate change, and spacecraft wobble, both singly and in combination. Methanol and water in combination with appropriate spin-rates and accelerations of the scale model system were used to simulate the behavior of fluorine, nitrogen tetroxide, monomethylhydrazine, and hydrazine. The experimental results indicate that no major fluid behavior problems would be encountered with the use of toroidal tanks containing any of the four propellants in a proposed spin-stabilized orbiter spacecraft.

Radiation Modeling with Direct Simulation Monte Carlo

NASA Technical Reports Server (NTRS)

Carlson, Ann B.; Hassan, H. A.

1991-01-01

Improvements in the modeling of radiation in low density shock waves with direct simulation Monte Carlo (DSMC) are the subject of this study. A new scheme to determine the relaxation collision numbers for excitation of electronic states is proposed. This scheme attempts to move the DSMC programs toward a more detailed modeling of the physics and more reliance on available rate data. The new method is compared with the current modeling technique and both techniques are compared with available experimental data. The differences in the results are evaluated. The test case is based on experimental measurements from the AVCO-Everett Research Laboratory electric arc-driven shock tube of a normal shock wave in air at 10 km/s and .1 Torr. The new method agrees with the available data as well as the results from the earlier scheme and is more easily extrapolated to di erent ow conditions.

Stability of Wavy Films in Gas-Liquid Two-Phase Flows at Normal and Microgravity Conditions

NASA Technical Reports Server (NTRS)

Balakotaiah, V.; Jayawardena, S. S.

1996-01-01

For flow rates of technological interest, most gas-liquid flows in pipes are in the annular flow regime, in which, the liquid moves along the pipe wall in a thin, wavy film and the gas flows in the core region. The waves appearing on the liquid film have a profound influence on the transfer rates, and hence on the design of these systems. We have recently proposed and analyzed two boundary layer models that describe the characteristics of laminar wavy films at high Reynolds numbers (300-1200). Comparison of model predictions to 1-g experimental data showed good agreement. The goal of our present work is to understand through a combined program of experimental and modeling studies the characteristics of wavy films in annular two-phase gas-liquid flows under normal as well as microgravity conditions in the developed and entry regions.

Report on carcinogens monograph on cumene.

PubMed

2013-09-01

The National Toxicology Program conducted a cancer evaluation on cumene for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for cumene in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to cumene. This monograph provides an assessment of the available scientific information on cumene, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that cumene be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found that cumene exposure caused lung tumors in male and female mice and liver tumors in female mice. Several proposed mechanisms of carcinogenesis support the relevance to humans of the lung and liver tumors observed in experimental animals. Specifically, there is evidence that humans and experimental animals metabolize cumene through similar metabolic pathways. In addition, mutations of the K-ras oncogene and p53 tumor-suppressor gene observed in cumene-induced lung tumors in mice, along with altered expression of many other genes, resemble molecular alterations found in human lung and other cancers.

ALCF Data Science Program: Productive Data-centric Supercomputing

NASA Astrophysics Data System (ADS)

Romero, Nichols; Vishwanath, Venkatram

The ALCF Data Science Program (ADSP) is targeted at big data science problems that require leadership computing resources. The goal of the program is to explore and improve a variety of computational methods that will enable data-driven discoveries across all scientific disciplines. The projects will focus on data science techniques covering a wide area of discovery including but not limited to uncertainty quantification, statistics, machine learning, deep learning, databases, pattern recognition, image processing, graph analytics, data mining, real-time data analysis, and complex and interactive workflows. Project teams will be among the first to access Theta, ALCFs forthcoming 8.5 petaflops Intel/Cray system. The program will transition to the 200 petaflop/s Aurora supercomputing system when it becomes available. In 2016, four projects have been selected to kick off the ADSP. The selected projects span experimental and computational sciences and range from modeling the brain to discovering new materials for solar-powered windows to simulating collision events at the Large Hadron Collider (LHC). The program will have a regular call for proposals with the next call expected in Spring 2017.http://www.alcf.anl.gov/alcf-data-science-program This research used resources of the ALCF, which is a DOE Office of Science User Facility supported under Contract DE-AC02-06CH11357.

Nuclear Test-Experimental Science: Annual report, fiscal year 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Struble, G.L.; Donohue, M.L.; Bucciarelli, G.

1988-01-01

Fiscal year 1988 has been a significant, rewarding, and exciting period for Lawrence Livermore National Laboratory's nuclear testing program. It was significant in that the Laboratory's new director chose to focus strongly on the program's activities and to commit to a revitalized emphasis on testing and the experimental science that underlies it. It was rewarding in that revolutionary new measurement techniques were fielded on recent important and highly complicated underground nuclear tests with truly incredible results. And it was exciting in that the sophisticated and fundamental problems of weapons science that are now being addressed experimentally are yielding new challengesmore » and understanding in ways that stimulate and reward the brightest and best of scientists. During FY88 the program was reorganized to emphasize our commitment to experimental science. The name of the program was changed to reflect this commitment, becoming the Nuclear Test-Experimental Science (NTES) Program.« less

76 FR 21372 - Medicare Program; Solicitation for Proposals for the Medicare Community-Based Care Transitions...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

...] Medicare Program; Solicitation for Proposals for the Medicare Community-Based Care Transitions Program... interested parties of an opportunity to apply to participate in the Medicare Community-based Care Transitions Program, which was authorized by section 3026 of the Affordable Care Act. DATES: Proposals will be...

77 FR 9218 - Tribally Controlled Postsecondary Career and Technical Institutions Program; Proposed Waivers and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... application process while lacking critical information about the future of the program, and we do not think... Program; Proposed Waivers and Extension of the Project Period; CFDA Number 84.245A AGENCY: Office of... Institutions Program (TCPCTIP), the Secretary proposes to waive the regulations that generally limit project...

78 FR 23775 - Notice of Proposed Information Collection; Comment Request: Tax Credit Assistance Program (TCAP)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... Information Collection; Comment Request: Tax Credit Assistance Program (TCAP) AGENCY: Office of the Chief... information: Title of Proposed: Tax Credit Assistance Program (TCAP). OMB Approval Number: 2506-0181. Form Numbers: None. Description of the need for the information and proposed use: Tax Credit Assistance Program...

The Use of Wiki in Teaching Programming: Effects upon Achievement, Attitudes, and Collaborative Programming Behaviors

ERIC Educational Resources Information Center

Lin, Yu-Tzu; Wu, Cheng-Chih; Chiu, Chiung-Fang

2018-01-01

This article explores the feasibility of employing cooperative program editing tools in teaching programming. A quasi-experimental study was conducted, in which the experimental group co-edited the programs with peers using the wiki. The control group co-edited the programs with peers using only the face-to-face approach. The findings show that…

Predicting the scanning branches of hysteretic soil water-retention capacity with use of the method of mathematical modeling

NASA Astrophysics Data System (ADS)

Terleev, V.; Ginevsky, R.; Lazarev, V.; Nikonorov, A.; Togo, I.; Topaj, A.; Moiseev, K.; Abakumov, E.; Melnichuk, A.; Dunaieva, I.

2017-10-01

A mathematical model of the hysteresis of the water-retention capacity of the soil is proposed. The parameters of the model are interpreted within the framework of physical concepts of the structure and capillary properties of soil pores. On the basis of the model, a computer program with an interface that allows for dialogue with the user is developed. The program has some of options: visualization of experimental data; identification of the model parameters with use of measured data by means of an optimizing algorithm; graphical presentation of the hysteresis loop with application of the assigned parameters. Using the program, computational experiments were carried out, which consisted in verifying the identifiability of the model parameters from data on the main branches, and also in testing the ability to predict the scanning branches of the hysteresis loop. For the experiments, literature data on two sandy soils were used. The absence of an “artificial pump effect” is proved. A sufficiently high accuracy of the prediction of the scanning branches of the hysteresis loop has been achieved in comparison with the three models of the precursors. The practical importance of the proposed model and computer program, which is developed on its basis, is to ensure the calculation of precision irrigation rates. The application of such rates in irrigation farming will help to prevent excess moisture from flowing beyond the root layer of the soil and, thus, minimize the unproductive loss of irrigation water and agrochemicals, as well as reduce the risk of groundwater contamination and natural water eutrophication.

47 CFR 5.305 - Program license not permitted.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Program license not permitted. 5.305 Section 5.305 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EXPERIMENTAL RADIO SERVICE Program Experimental Radio Licenses § 5.305 Program license not permitted. Experiments are not permitted under this...

47 CFR 5.305 - Program license not permitted.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Program license not permitted. 5.305 Section 5.305 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EXPERIMENTAL RADIO SERVICE Program Experimental Radio Licenses § 5.305 Program license not permitted. Experiments are not permitted under this...

Paradox of vaccination: is vaccination really effective against avian flu epidemics?

PubMed

Iwami, Shingo; Suzuki, Takafumi; Takeuchi, Yasuhiro

2009-01-01

Although vaccination can be a useful tool for control of avian influenza epidemics, it might engender emergence of a vaccine-resistant strain. Field and experimental studies show that some avian influenza strains acquire resistance ability against vaccination. We investigated, in the context of the emergence of a vaccine-resistant strain, whether a vaccination program can prevent the spread of infectious disease. We also investigated how losses from immunization by vaccination imposed by the resistant strain affect the spread of the disease. We designed and analyzed a deterministic compartment model illustrating transmission of vaccine-sensitive and vaccine-resistant strains during a vaccination program. We investigated how the loss of protection effectiveness impacts the program. Results show that a vaccination to prevent the spread of disease can instead spread the disease when the resistant strain is less virulent than the sensitive strain. If the loss is high, the program does not prevent the spread of the resistant strain despite a large prevalence rate of the program. The epidemic's final size can be larger than that before the vaccination program. We propose how to use poor vaccines, which have a large loss, to maximize program effects and describe various program risks, which can be estimated using available epidemiological data. We presented clear and simple concepts to elucidate vaccination program guidelines to avoid negative program effects. Using our theory, monitoring the virulence of the resistant strain and investigating the loss caused by the resistant strain better development of vaccination strategies is possible.

An experimental investigation of a Mach 3.0 high-speed civil transport at supersonic speeds

NASA Technical Reports Server (NTRS)

Hernandez, Gloria; Covell, Peter F.; Mcgraw, Marvin E., Jr.

1993-01-01

An experimental study was conducted to determine the aerodynamic characteristics of a proposed high speed civil transport. This configuration was designed to cruise at Mach 3.0 and sized to carry 250 passengers for 6500 n.mi. The configuration consists of a highly blended wing body and features a blunt parabolic nose planform, a highly swept inboard wing panel, a moderately swept outboard wing panel, and a curved wingtip. Wind tunnel tests were conducted in the Langley Unitary Plan Wind Tunnel on a 0.0098-scale model. Force, moment, and pressure data were obtained for Mach numbers ranging from 1.6 to 3.6 and at angles of attack ranging from -4 to 10 deg. Extensive flow visualization studies (vapor screen and oil flow) were obtained in the experimental program. Both linear and advanced computational fluid dynamics (CFD) theoretical comparisons are shown to assess the ability to predict forces, moments, and pressures on configurations of this type. In addition, an extrapolation of the wind tunnel data, based on empirical principles, to full-scale conditions is compared with the theoretical aerodynamic predictions.

Introducing survival ethics into engineering education and practice.

PubMed

Verharen, C; Tharakan, J; Middendorf, G; Castro-Sitiriche, M; Kadoda, G

2013-06-01

Given the possibilities of synthetic biology, weapons of mass destruction and global climate change, humans may achieve the capacity globally to alter life. This crisis calls for an ethics that furnishes effective motives to take global action necessary for survival. We propose a research program for understanding why ethical principles change across time and culture. We also propose provisional motives and methods for reaching global consensus on engineering field ethics. Current interdisciplinary research in ethics, psychology, neuroscience and evolutionary theory grounds these proposals. Experimental ethics, the application of scientific principles to ethical studies, provides a model for developing policies to advance solutions. A growing literature proposes evolutionary explanations for moral development. Connecting these approaches necessitates an experimental or scientific ethics that deliberately examines theories of morality for reliability. To illustrate how such an approach works, we cover three areas. The first section analyzes cross-cultural ethical systems in light of evolutionary theory. While such research is in its early stages, its assumptions entail consequences for engineering education. The second section discusses Howard University and University of Puerto Rico/Mayagüez (UPRM) courses that bring ethicists together with scientists and engineers to unite ethical theory and practice. We include a syllabus for engineering and STEM (Science, Technology, Engineering and Mathematics) ethics courses and a checklist model for translating educational theory and practice into community action. The model is based on aviation, medicine and engineering practice. The third and concluding section illustrates Howard University and UPRM efforts to translate engineering educational theory into community action. Multidisciplinary teams of engineering students and instructors take their expertise from the classroom to global communities to examine further the ethicality of prospective technologies and the decision-making processes that lead to them.

The impact of education regarding the needs of pediatric leukemia patients' siblings on the parents' knowledge and practice.

PubMed

Hashemi, Fatemeh; Shokrpour, Nasrin

2010-01-01

A study was undertaken to determine the effect of educational intervention on parents' knowledge and performance of the social needs of the healthy siblings of the pediatric leukemia patients. Inadequate care and attention to siblings of pediatric leukemia patients might result in psychosomatic disorders. Parents' knowledge on prevention of such disorders is of great importance. The study proposed to determine the effects of educational intervention concerning parents. Sixty parents of pediatric leukemia patients entered this study. The subjects were selected using convenient sampling method and were randomly categorized into 2 groups: experimental and control. Data were collected before, 1 hour after, and 2 months after the intervention, using a questionnaire. The educational program was arranged in 3 sessions, each lasting 45 to 60 minutes using group discussion and lectures for the parents of the experimental group. Then, the parents were instructed individually, if necessary. The mean scores of the parents' knowledge in the experimental and control groups before the intervention were 5.8 and 6.2, respectively. One hour after instruction, the mean rose to 12.8 and 6.4, and 2 months later to 13.3 and 6.5 (p < .00l). The family performance of 87.2% of the parents in the experimental group and 36.4% of the control group toward the siblings of the sick child was appropriate 2 months after the intervention. Therefore, educational intervention increased the knowledge of the parents of pediatric leukemia patients about the needs of the healthy siblings and how to meet them. It is recommended that educational programs be arranged for parents so that the quality of life in the healthy children can be improved.

X-33 Experimental Aeroheating at Mach 6 Using Phosphor Thermography

NASA Technical Reports Server (NTRS)

Horvath, Thomas J.; Berry, Scott A.; Hollis, Brian R.; Liechty, Derek S.; Hamilton, H. Harris, II; Merski, N. Ronald

1999-01-01

The goal of the NASA Reusable Launch Vehicle (RLV) technology program is to mature and demonstrate essential, cost effective technologies for next generation launch systems. The X-33 flight vehicle presently being developed by Lockheed Martin is an experimental Single Stage to Orbit (SSTO) demonstrator that seeks to validate critical technologies and insure applicability to a full scale RLV. As with the design of any hypersonic vehicle, the aeroheating environment is an important issue and one of the key technologies being demonstrated on X-33 is an advanced metallic Thermal Protection System (TPS). As part of the development of this TPS system, the X-33 aeroheating environment is being defined through conceptual analysis, ground based testing, and computational fluid dynamics. This report provides an overview of the hypersonic aeroheating wind tunnel program conducted at the NASA Langley Research Center in support of the ground based testing activities. Global surface heat transfer images, surface streamline patterns, and shock shapes were measured on 0.013 scale (10-in.) ceramic models of the proposed X-33 configuration in Mach 6 air. The test parametrics include angles of attack from -5 to 40 degs, unit Reynolds numbers from 1x106 to 8x106/ft, and body flap deflections of 0, 10, and 20 deg. Experimental and computational results indicate the presence of shock/shock interactions that produced localized heating on the deflected flaps and boundary layer transition on the canted fins. Comparisons of the experimental data to laminar and turbulent predictions were performed. Laminar windward heating data from the wind tunnel was extrapolated to flight surface temperatures and generally compared to within 50 deg F of flight prediction along the centerline. When coupled with the phosphor technique, this rapid extrapolation method would serve as an invaluable TPS design tool.

Modeling eutrophic lakes: From mass balance laws to ordinary differential equations

NASA Astrophysics Data System (ADS)

Marasco, Addolorata; Ferrara, Luciano; Romano, Antonio

Starting from integral balance laws, a model based on nonlinear ordinary differential equations (ODEs) describing the evolution of Phosphorus cycle in a lake is proposed. After showing that the usual homogeneous model is not compatible with the mixture theory, we prove that an ODEs model still holds but for the mean values of the state variables provided that the nonhomogeneous involved fields satisfy suitable conditions. In this model the trophic state of a lake is described by the mean densities of Phosphorus in water and sediments, and phytoplankton biomass. All the quantities appearing in the model can be experimentally evaluated. To propose restoration programs, the evolution of these state variables toward stable steady state conditions is analyzed. Moreover, the local stability analysis is performed with respect to all the model parameters. Some numerical simulations and a real application to lake Varese conclude the paper.

Design of Control Plane Architecture Based on Cloud Platform and Experimental Network Demonstration for Multi-domain SDON

NASA Astrophysics Data System (ADS)

Li, Ming; Yin, Hongxi; Xing, Fangyuan; Wang, Jingchao; Wang, Honghuan

2016-02-01

With the features of network virtualization and resource programming, Software Defined Optical Network (SDON) is considered as the future development trend of optical network, provisioning a more flexible, efficient and open network function, supporting intraconnection and interconnection of data centers. Meanwhile cloud platform can provide powerful computing, storage and management capabilities. In this paper, with the coordination of SDON and cloud platform, a multi-domain SDON architecture based on cloud control plane has been proposed, which is composed of data centers with database (DB), path computation element (PCE), SDON controller and orchestrator. In addition, the structure of the multidomain SDON orchestrator and OpenFlow-enabled optical node are proposed to realize the combination of centralized and distributed effective management and control platform. Finally, the functional verification and demonstration are performed through our optical experiment network.

Fast viscosity solutions for shape from shading under a more realistic imaging model

NASA Astrophysics Data System (ADS)

Wang, Guohui; Han, Jiuqiang; Jia, Honghai; Zhang, Xinman

2009-11-01

Shape from shading (SFS) has been a classical and important problem in the domain of computer vision. The goal of SFS is to reconstruct the 3-D shape of an object from its 2-D intensity image. To this end, an image irradiance equation describing the relation between the shape of a surface and its corresponding brightness variations is used. Then it is derived as an explicit partial differential equation (PDE). Using the nonlinear programming principle, we propose a detailed solution to Prados and Faugeras's implicit scheme for approximating the viscosity solution of the resulting PDE. Furthermore, by combining implicit and semi-implicit schemes, a new approximation scheme is presented. In order to accelerate the convergence speed, we adopt the Gauss-Seidel idea and alternating sweeping strategy to the approximation schemes. Experimental results on both synthetic and real images are performed to demonstrate that the proposed methods are fast and accurate.

Malware Analysis Using Visualized Image Matrices

PubMed Central

Im, Eul Gyu

2014-01-01

This paper proposes a novel malware visual analysis method that contains not only a visualization method to convert binary files into images, but also a similarity calculation method between these images. The proposed method generates RGB-colored pixels on image matrices using the opcode sequences extracted from malware samples and calculates the similarities for the image matrices. Particularly, our proposed methods are available for packed malware samples by applying them to the execution traces extracted through dynamic analysis. When the images are generated, we can reduce the overheads by extracting the opcode sequences only from the blocks that include the instructions related to staple behaviors such as functions and application programming interface (API) calls. In addition, we propose a technique that generates a representative image for each malware family in order to reduce the number of comparisons for the classification of unknown samples and the colored pixel information in the image matrices is used to calculate the similarities between the images. Our experimental results show that the image matrices of malware can effectively be used to classify malware families both statically and dynamically with accuracy of 0.9896 and 0.9732, respectively. PMID:25133202

Feature Grouping and Selection Over an Undirected Graph.

PubMed

Yang, Sen; Yuan, Lei; Lai, Ying-Cheng; Shen, Xiaotong; Wonka, Peter; Ye, Jieping

2012-01-01

High-dimensional regression/classification continues to be an important and challenging problem, especially when features are highly correlated. Feature selection, combined with additional structure information on the features has been considered to be promising in promoting regression/classification performance. Graph-guided fused lasso (GFlasso) has recently been proposed to facilitate feature selection and graph structure exploitation, when features exhibit certain graph structures. However, the formulation in GFlasso relies on pairwise sample correlations to perform feature grouping, which could introduce additional estimation bias. In this paper, we propose three new feature grouping and selection methods to resolve this issue. The first method employs a convex function to penalize the pairwise l ∞ norm of connected regression/classification coefficients, achieving simultaneous feature grouping and selection. The second method improves the first one by utilizing a non-convex function to reduce the estimation bias. The third one is the extension of the second method using a truncated l 1 regularization to further reduce the estimation bias. The proposed methods combine feature grouping and feature selection to enhance estimation accuracy. We employ the alternating direction method of multipliers (ADMM) and difference of convex functions (DC) programming to solve the proposed formulations. Our experimental results on synthetic data and two real datasets demonstrate the effectiveness of the proposed methods.

Slug Flow Analysis in Vertical Large Diameter Pipes

NASA Astrophysics Data System (ADS)

Roullier, David

The existence of slug flow in vertical co-current two-phase flow is studied experimentally and theoretically. The existence of slug flow in vertical direction implies the presence of Taylor bubbles separated by hydraulically sealed liquid slugs. Previous experimental studies such as Ombere-Ayari and Azzopardi (2007) showed the evidence of the non-existence of Taylor bubbles for extensive experimental conditions. Models developed to predict experimental behavior [Kocamustafaogullari et al. (1984), Jayanti and Hewitt. (1990) and Kjoolas et al. (2017)] suggest that Taylor bubbles may disappear at large diameters and high velocities. A 73-ft tall and 101.6-mm internal diameter test facility was used to conduct the experiments allowing holdup and pressure drop measurements at large L/D. Superficial liquid and gas velocities varied from 0.05-m/s to 0.2 m/s and 0.07 m/s to 7.5 m/s, respectively. Test section pressure varied from 38 psia to 84 psia. Gas compressibility effect was greatly reduced at 84 psia. The experimental program allowed to observe the flow patterns for flowing conditions near critical conditions predicted by previous models (air-water, 1016 mm ID, low mixture velocities). Flow patterns were observed in detail using wire-mesh sensor measurements. Slug-flow was observed for a narrow range of experimental conditions at low velocities. Churn-slug and churn-annular flows were observed for most of the experimental data-points. Cap-bubble flow was observed instead of bubbly flow at low vSg. Wire-mesh measurements showed that the liquid has a tendency to remain near to the walls. The standard deviation of radial holdup profile correlates to the flow pattern observed. For churn-slug flow, the profile is convex with a single maximum near the pipe center while it exhibits a concave shape with two symmetric maxima close to the wall for churn-annular flow. The translational velocity was measured by two consecutive wire-mesh sensor crosscorrelation. The results show linear trends at low mixture velocities and non-linear behaviors at high mixture velocities. The translational velocity trends seem to be related to the flow-pattern observed, namely to the ability of the gas to flow through the liquid structures. A simplified Taylor bubble stability model is proposed. The model allows to estimate under which conditions Taylor bubbles disappear, properly accounting for the diameter effect and velocity effect observed experimentally. In addition, annular flow distribution coefficient relating true holdup to centerline holdup in vertical flow is proposed. The proposed coefficient defines the tendency of the liquid to remain near the walls. This coefficient increases linearly with the void fraction.

EVALUATION OF EXPERIMENTAL PRESCHOOL PROGRAM FOR EDUCATIONALLY DEPRIVED CHILDREN (1964).

ERIC Educational Resources Information Center

STEWART, LUCILLE M.

THE AIM OF AN EXPERIMENTAL PRESCHOOL PROGRAM FOR EDUCATIONALLY DEPRIVED CHILDREN WAS TO PREPARE THEM FOR REGULAR KINDERGARTEN CLASSES. ACTIVITIES AND EXPERIENCES WERE PROVIDED WHICH HELPED THE CHILDREN EXPRESS THEMSELVES VERBALLY AND BECOME AWARE OF THEIR ENVIRONMENT. THE BUDGET FOR A 6-WEEK PROGRAM, INCLUDING STAFF, PROGRAM SUPPLIES, AND…

Social cohesion through football: a quasi-experimental mixed methods design to evaluate a complex health promotion program

PubMed Central

2010-01-01

Social isolation and disengagement fragments local communities. Evidence indicates that refugee families are highly vulnerable to social isolation in their countries of resettlement. Research to identify approaches to best address this is needed. Football United is a program that aims to foster social inclusion and cohesion in areas with high refugee settlement in New South Wales, Australia, through skills and leadership development, mentoring, and the creation of links with local community and corporate leaders and organisations. The Social Cohesion through Football study's broad goal is to examine the implementation of a complex health promotion program, and to analyse the processes involved in program implementation. The study will consider program impact on individual health and wellbeing, social inclusion and cohesion, as well as analyse how the program by necessity interacts and adapts to context during implementation, a concept we refer to as plasticity. The proposed study will be the first prospective cohort impact study to our knowledge to assess the impact of a comprehensive integrated program using football as a vehicle for fostering social inclusion and cohesion in communities with high refugee settlement. Methods/design A quasi-experimental cohort study design with treatment partitioning involving four study sites. The study employs a 'dose response' model, comparing those with no involvement in the Football United program with those with lower or higher levels of participation. A range of qualitative and quantitative measures will be used in the study. Study participants' emotional well being, resilience, ethnic identity and other group orientation, feelings of social inclusion and belonging will be measured using a survey instrument complemented by relevant data drawn from in-depth interviews, self reporting measures and participant observation. The views of key informants from the program and the wider community will also be solicited. Discussion The complexity of the Football United program poses challenges for measurement, and requires the study design to be responsive to the dynamic nature of the program and context. Assessment of change is needed at multiple levels, drawing on mixed methods and multidisciplinary approaches in implementation and evaluation. Attention to these challenges has underpinned the design and methods in the Social Cohesion through Football study, which will use a unique and innovative combination of measures that have not been applied together previously in social inclusion/cohesion and sport and social inclusion/cohesion program research. PMID:20920361

Social cohesion through football: a quasi-experimental mixed methods design to evaluate a complex health promotion program.

PubMed

Nathan, Sally; Bunde-Birouste, Anne; Evers, Clifton; Kemp, Lynn; MacKenzie, Julie; Henley, Robert

2010-10-05

Social isolation and disengagement fragments local communities. Evidence indicates that refugee families are highly vulnerable to social isolation in their countries of resettlement. Research to identify approaches to best address this is needed. Football United is a program that aims to foster social inclusion and cohesion in areas with high refugee settlement in New South Wales, Australia, through skills and leadership development, mentoring, and the creation of links with local community and corporate leaders and organisations. The Social Cohesion through Football study's broad goal is to examine the implementation of a complex health promotion program, and to analyse the processes involved in program implementation. The study will consider program impact on individual health and wellbeing, social inclusion and cohesion, as well as analyse how the program by necessity interacts and adapts to context during implementation, a concept we refer to as plasticity. The proposed study will be the first prospective cohort impact study to our knowledge to assess the impact of a comprehensive integrated program using football as a vehicle for fostering social inclusion and cohesion in communities with high refugee settlement. A quasi-experimental cohort study design with treatment partitioning involving four study sites. The study employs a 'dose response' model, comparing those with no involvement in the Football United program with those with lower or higher levels of participation. A range of qualitative and quantitative measures will be used in the study. Study participants' emotional well being, resilience, ethnic identity and other group orientation, feelings of social inclusion and belonging will be measured using a survey instrument complemented by relevant data drawn from in-depth interviews, self reporting measures and participant observation. The views of key informants from the program and the wider community will also be solicited. The complexity of the Football United program poses challenges for measurement, and requires the study design to be responsive to the dynamic nature of the program and context. Assessment of change is needed at multiple levels, drawing on mixed methods and multidisciplinary approaches in implementation and evaluation. Attention to these challenges has underpinned the design and methods in the Social Cohesion through Football study, which will use a unique and innovative combination of measures that have not been applied together previously in social inclusion/cohesion and sport and social inclusion/cohesion program research.

Solar energy program evaluation: an introduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

deLeon, P.

The Program Evaluation Methodology provides an overview of the practice and methodology of program evaluation and defines more precisely the evaluation techniques and methodologies that would be most appropriate to government organizations which are actively involved in the research, development, and commercialization of solar energy systems. Formal evaluation cannot be treated as a single methodological approach for assessing a program. There are four basic types of evaluation designs - the pre-experimental design; the quasi-experimental design based on time series; the quasi-experimental design based on comparison groups; and the true experimental design. This report is organized to first introduce the rolemore » and issues of evaluation. This is to provide a set of issues to organize the subsequent sections detailing the national solar energy programs. Then, these two themes are integrated by examining the evaluation strategies and methodologies tailored to fit the particular needs of the various individual solar energy programs. (MCW)« less

75 FR 75713 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-06

... Effectiveness of Proposed Rule Change Related to the Penny Pilot Program November 29, 2010. Pursuant to Section... proposing to amend its rules relating to the Penny Pilot Program. The text of the proposed rule change is... 1. Purpose The Penny Pilot Program is scheduled to expire on December 31, 2010. CBOE proposes to...

[Evaluation of an education program for patients with asthma who use inhalers].

PubMed

Lee, Jong Kyung; Yang, Young Hee

2010-04-01

This study was done to evaluate the effectiveness of an education program for patients with asthma who use inhalers. The research design for this study was a non-equivalent control group quasi-experimental study. Participants in this study were 36 patients for the control group, and 43 patients for the experimental group. The experimental group participated in the education program. The control group received the usual care. Data were collected before and 1 month and 2 months after the program finished and were analyzed using the SPSS 12.0 program. The experimental group had significantly higher scores of knowledge of inhalers, and inhalation technique compared to the control group. However, no significant differences were found between two groups for PEFR, asthma instability, and satisfaction with inhalers. According to the results, the education program was effective in improving knowledge of inhalers, and inhalation technique. Therefore, it is recommended that this education program be used in clinical practice as an effective nursing intervention for patients with asthma on inhalers.

A comparison of performance of several artificial intelligence methods for predicting the dynamic viscosity of TiO2/SAE 50 nano-lubricant

NASA Astrophysics Data System (ADS)

Hemmat Esfe, Mohammad; Tatar, Afshin; Ahangar, Mohammad Reza Hassani; Rostamian, Hossein

2018-02-01

Since the conventional thermal fluids such as water, oil, and ethylene glycol have poor thermal properties, the tiny solid particles are added to these fluids to increase their heat transfer improvement. As viscosity determines the rheological behavior of a fluid, studying the parameters affecting the viscosity is crucial. Since the experimental measurement of viscosity is expensive and time consuming, predicting this parameter is the apt method. In this work, three artificial intelligence methods containing Genetic Algorithm-Radial Basis Function Neural Networks (GA-RBF), Least Square Support Vector Machine (LS-SVM) and Gene Expression Programming (GEP) were applied to predict the viscosity of TiO2/SAE 50 nano-lubricant with Non-Newtonian power-law behavior using experimental data. The correlation factor (R2), Average Absolute Relative Deviation (AARD), Root Mean Square Error (RMSE), and Margin of Deviation were employed to investigate the accuracy of the proposed models. RMSE values of 0.58, 1.28, and 6.59 and R2 values of 0.99998, 0.99991, and 0.99777 reveal the accuracy of the proposed models for respective GA-RBF, CSA-LSSVM, and GEP methods. Among the developed models, the GA-RBF shows the best accuracy.

Dynamic contraction behaviour of pneumatic artificial muscle

NASA Astrophysics Data System (ADS)

Doumit, Marc D.; Pardoel, Scott

2017-07-01

The development of a dynamic model for the Pneumatic Artificial Muscle (PAM) is an imperative undertaking for understanding and analyzing the behaviour of the PAM as a function of time. This paper proposes a Newtonian based dynamic PAM model that includes the modeling of the muscle geometry, force, inertia, fluid dynamic, static and dynamic friction, heat transfer and valve flow while ignoring the effect of bladder elasticity. This modeling contribution allows the designer to predict, analyze and optimize PAM performance prior to its development. Thus advancing successful implementations of PAM based powered exoskeletons and medical systems. To date, most muscle dynamic properties are determined experimentally, furthermore, no analytical models that can accurately predict the muscle's dynamic behaviour are found in the literature. Most developed analytical models adequately predict the muscle force in static cases but neglect the behaviour of the system in the transient response. This could be attributed to the highly challenging task of deriving such a dynamic model given the number of system elements that need to be identified and the system's highly non-linear properties. The proposed dynamic model in this paper is successfully simulated through MATLAB programing and validated the pressure, contraction distance and muscle temperature with experimental testing that is conducted with in-house built prototype PAM's.

Laser Technician Associate Degree Program. A Proposal Submitted to Wisconsin State Board of Vocational, Technical, and Adult Education. (Curriculum Development.) Final Report.

ERIC Educational Resources Information Center

North Central Technical Inst., Wausau, WI.

This final report contains the program proposal with supporting data for developing curriculum materials for and implementing an associate-degree laser technology program at the North Central Technical Institute. The proposal outline provides this information: (1) objectives for the program designed to prepare a technician to safely operate,…

Stereo Image Dense Matching by Integrating Sift and Sgm Algorithm

NASA Astrophysics Data System (ADS)

Zhou, Y.; Song, Y.; Lu, J.

2018-05-01

Semi-global matching(SGM) performs the dynamic programming by treating the different path directions equally. It does not consider the impact of different path directions on cost aggregation, and with the expansion of the disparity search range, the accuracy and efficiency of the algorithm drastically decrease. This paper presents a dense matching algorithm by integrating SIFT and SGM. It takes the successful matching pairs matched by SIFT as control points to direct the path in dynamic programming with truncating error propagation. Besides, matching accuracy can be improved by using the gradient direction of the detected feature points to modify the weights of the paths in different directions. The experimental results based on Middlebury stereo data sets and CE-3 lunar data sets demonstrate that the proposed algorithm can effectively cut off the error propagation, reduce disparity search range and improve matching accuracy.

A Novel Joint Problem of Routing, Scheduling, and Variable-Width Channel Allocation in WMNs

PubMed Central

Liu, Wan-Yu; Chou, Chun-Hung

2014-01-01

This paper investigates a novel joint problem of routing, scheduling, and channel allocation for single-radio multichannel wireless mesh networks in which multiple channel widths can be adjusted dynamically through a new software technology so that more concurrent transmissions and suppressed overlapping channel interference can be achieved. Although the previous works have studied this joint problem, their linear programming models for the problem were not incorporated with some delicate constraints. As a result, this paper first constructs a linear programming model with more practical concerns and then proposes a simulated annealing approach with a novel encoding mechanism, in which the configurations of multiple time slots are devised to characterize the dynamic transmission process. Experimental results show that our approach can find the same or similar solutions as the optimal solutions for smaller-scale problems and can efficiently find good-quality solutions for a variety of larger-scale problems. PMID:24982990

Reactivity of young chars via energetic distribution measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calo, J.M.; Lilly, W.D.

1991-01-01

The current project is directed at developing related techniques for the characterization and prediction/correlation of the reactivity of young'' chars to steam and oxygen. Of particular interest is mapping of the reactivity behavior of the resultant chars, as revealed by the energetic heterogeneity of the complexes with char preparation conditions; i.e., heating rate and ultimate temperature. In this first quarterly technical progress report we present the background of the project and the research program for the proposed investigations. The following work was accomplished on the experimental apparatus: a new set of electronics for the UTi quadrupole mass spectrometer head wasmore » purchased and delivered. The Temperature Programmed Desorption (TPD) System was moved to another laboratory and interfaced with the mass spectrometer system. A Polycold{trademark} freon refrigeration system was repaired and interfaced with the vacuum system for the TPD apparatus. It will be used to cool the diffusion pump trap. 60 refs.« less

Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications.

PubMed

Sasse, Sarah K; Gerber, Anthony N

2015-01-01

Nuclear receptors (NRs) are widely targeted to treat a range of human diseases. Feed-forward loops are an ancient mechanism through which single cell organisms organize transcriptional programming and modulate gene expression dynamics, but they have not been systematically studied as a regulatory paradigm for NR-mediated transcriptional responses. Here, we provide an overview of the basic properties of feed-forward loops as predicted by mathematical models and validated experimentally in single cell organisms. We review existing evidence implicating feed-forward loops as important in controlling clinically relevant transcriptional responses to estrogens, progestins, and glucocorticoids, among other NR ligands. We propose that feed-forward transcriptional circuits are a major mechanism through which NRs integrate signals, exert temporal control over gene regulation, and compartmentalize client transcriptomes into discrete subunits. Implications for the design and function of novel selective NR ligands are discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

A Generalized National Planning Approach for Admission Capacity in Higher Education: A Nonlinear Integer Goal Programming Model with a Novel Differential Evolution Algorithm

PubMed Central

El-Qulity, Said Ali; Mohamed, Ali Wagdy

2016-01-01

This paper proposes a nonlinear integer goal programming model (NIGPM) for solving the general problem of admission capacity planning in a country as a whole. The work aims to satisfy most of the required key objectives of a country related to the enrollment problem for higher education. The system general outlines are developed along with the solution methodology for application to the time horizon in a given plan. The up-to-date data for Saudi Arabia is used as a case study and a novel evolutionary algorithm based on modified differential evolution (DE) algorithm is used to solve the complexity of the NIGPM generated for different goal priorities. The experimental results presented in this paper show their effectiveness in solving the admission capacity for higher education in terms of final solution quality and robustness. PMID:26819583

A Generalized National Planning Approach for Admission Capacity in Higher Education: A Nonlinear Integer Goal Programming Model with a Novel Differential Evolution Algorithm.

PubMed

El-Qulity, Said Ali; Mohamed, Ali Wagdy

2016-01-01

This paper proposes a nonlinear integer goal programming model (NIGPM) for solving the general problem of admission capacity planning in a country as a whole. The work aims to satisfy most of the required key objectives of a country related to the enrollment problem for higher education. The system general outlines are developed along with the solution methodology for application to the time horizon in a given plan. The up-to-date data for Saudi Arabia is used as a case study and a novel evolutionary algorithm based on modified differential evolution (DE) algorithm is used to solve the complexity of the NIGPM generated for different goal priorities. The experimental results presented in this paper show their effectiveness in solving the admission capacity for higher education in terms of final solution quality and robustness.

Prediction of elemental creep. [steady state and cyclic data from regression analysis

NASA Technical Reports Server (NTRS)

Davis, J. W.; Rummler, D. R.

1975-01-01

Cyclic and steady-state creep tests were performed to provide data which were used to develop predictive equations. These equations, describing creep as a function of stress, temperature, and time, were developed through the use of a least squares regression analyses computer program for both the steady-state and cyclic data sets. Comparison of the data from the two types of tests, revealed that there was no significant difference between the cyclic and steady-state creep strains for the L-605 sheet under the experimental conditions investigated (for the same total time at load). Attempts to develop a single linear equation describing the combined steady-state and cyclic creep data resulted in standard errors of estimates higher than obtained for the individual data sets. A proposed approach to predict elemental creep in metals uses the cyclic creep equation and a computer program which applies strain and time hardening theories of creep accumulation.

Advanced technology for reducing aircraft engine pollution

NASA Technical Reports Server (NTRS)

Jones, R. E.

1973-01-01

The proposed EPA regulations covering emissions of gas turbine engines will require extensive combustor development. The NASA is working to develop technology to meet these goals through a wide variety of combustor research programs conducted in-house, by contract, and by university grant. In-house efforts using the swirl-can modular combustor have demonstrated sizable reduction in NO emission levels. Testing to reduce idle pollutants has included the modification of duplex fuel nozzles to air-assisted nozzles and an exploration of the potential improvements possible with combustors using fuel staging and variable geometry. The Experimental Clean Combustor Program, a large contracted effort, is devoted to the testing and development of combustor concepts designed to achieve a large reduction in the levels of all emissions. This effort is planned to be conducted in three phases with the final phase to be an engine demonstration of the best reduced emission concepts.

Degree-Pruning Dynamic Programming Approaches to Central Time Series Minimizing Dynamic Time Warping Distance.

PubMed

Sun, Tao; Liu, Hongbo; Yu, Hong; Chen, C L Philip

2016-06-28

The central time series crystallizes the common patterns of the set it represents. In this paper, we propose a global constrained degree-pruning dynamic programming (g(dp)²) approach to obtain the central time series through minimizing dynamic time warping (DTW) distance between two time series. The DTW matching path theory with global constraints is proved theoretically for our degree-pruning strategy, which is helpful to reduce the time complexity and computational cost. Our approach can achieve the optimal solution between two time series. An approximate method to the central time series of multiple time series [called as m_g(dp)²] is presented based on DTW barycenter averaging and our g(dp)² approach by considering hierarchically merging strategy. As illustrated by the experimental results, our approaches provide better within-group sum of squares and robustness than other relevant algorithms.

Effects of a Stretching Development and Maintenance Program on Hamstring Extensibility in Schoolchildren: A Cluster-Randomized Controlled Trial

PubMed Central

Mayorga-Vega, Daniel; Merino-Marban, Rafael; Manzano-Lagunas, Jorge; Blanco, Humberto; Viciana, Jesús

2016-01-01

The main purpose of the present study was to examine the effects of a physical education-based stretching development and maintenance program on hamstring extensibility in schoolchildren. A sample of 150 schoolchildren aged 7-10 years old from a primary school participated in the present study (140 participants were finally included). The six classes balanced by grade were cluster randomly assigned to the experimental group 1 (n = 51), experimental group 2 (n = 51) or control group (n = 49) (i.e., a cluster randomized controlled trial design was used). During the physical education classes, the students from the experimental groups 1 and 2 performed a four-minute stretching program twice a week for nine weeks (first semester). Then, after a five-week period of detraining coinciding with the Christmas holidays, the students from the experimental groups 1 and 2 completed another stretching program twice a week for eleven weeks (second semester). The students from the experimental group 1 continued performing the stretching program for four minutes while those from the experimental group 2 completed a flexibility maintenance program for only one minute. The results of the two-way analysis of variance showed that the physical education-based stretching development program significantly improved the students’ hamstring extensibility (p < 0.001), as well as that these gains obtained remained after the stretching maintenance program (p < 0.001). Additionally, statistically significant differences between the two experimental groups were not found (p > 0.05). After a short-term stretching development program, a physical education-based stretching maintenance program of only one-minute sessions twice a week is effective in maintaining hamstring extensibility among schoolchildren. This knowledge could help and guide teachers to design programs that allow a feasible and effective development and maintenance of students’ flexibility in the physical education setting. Key points A physical education-based stretching maintenance program of only one-minute sessions twice a week is effective in maintaining hamstring extensibility among schoolchildren. A four-minute maintenance program shows similar effects that the one-minute maintenance program on hamstring extensibility among schoolchildren. Physical education teachers and other practitioners could carry out one-minute programs for a feasible and effective maintenance of students’ flexibility. PMID:26957928

Overview of NASA tire experimental programs

NASA Technical Reports Server (NTRS)

Tanner, J. A.

1983-01-01

Ongoing aircraft tire experimental programs are reported. These programs are designed to measure profile growth due to inflation pressure and vertical loading, contact pressures in the tire footprint, and a number of tire mechanical properties including spring, damping, and relaxation characteristics.

UIUC concrete tie and fastener field testing at TTC.

DOT National Transportation Integrated Search

2014-07-01

In July 2012, the University of Illinois at Urbana-Champaign (UIUC) began an extensive : experimental program at the Transportation : Technology Center (TTC) in Pueblo, CO. The : field experimentation program was part of a : larger research program f...

Hydrology and radionuclide migration program 1987 progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marsh, K.V.

1991-03-01

This report presents results from the Lawrence Livermore National Laboratory's participation in the Hydrology and Radionuclide Migration Program at the Nevada Test Site (NTS) during the fiscal year 1987. The report discussed initial data from a new well (UE20n-1) drilled at the Cheshire site; presents a description of a proposed laboratory study of migration of colloids in fractured media; lists data collected during the drilling and initial sampling of UE20n-1; and describes a tentative proposal for work to be performed in FY88 by Lamont-Doherty Geological Observatory. Groundwater sampled from the new well at the Cheshire site contains tritium concentrations comparablemore » to those measured in previous years from locations above and within the Cheshire cavity. This presence of tritium, as well as several other radionuclides, in a well 100 m away from the cavity region indicates transport of radionuclides, validates a proposed model of the flow path, and provides data on rates of groundwater flow. Previous work at the Cheshire site has shown that radionuclides are transported by colloids through fractured media. However, we have no data that can be used for predictive modeling, and existing theories are not applicable. While physical transport mechanisms of sub-micrometer colloids to defined mineral surfaces are well known, predictions based on well-defined conditions differ from experimental observations by orders of magnitude. The U.C. Berkeley group has designed a laboratory experiment to quantify colloid retention and permeability alteration by the retained colloids.« less

Automated torso organ segmentation from 3D CT images using structured perceptron and dual decomposition

NASA Astrophysics Data System (ADS)

Nimura, Yukitaka; Hayashi, Yuichiro; Kitasaka, Takayuki; Mori, Kensaku

2015-03-01

This paper presents a method for torso organ segmentation from abdominal CT images using structured perceptron and dual decomposition. A lot of methods have been proposed to enable automated extraction of organ regions from volumetric medical images. However, it is necessary to adjust empirical parameters of them to obtain precise organ regions. This paper proposes an organ segmentation method using structured output learning. Our method utilizes a graphical model and binary features which represent the relationship between voxel intensities and organ labels. Also we optimize the weights of the graphical model by structured perceptron and estimate the best organ label for a given image by dynamic programming and dual decomposition. The experimental result revealed that the proposed method can extract organ regions automatically using structured output learning. The error of organ label estimation was 4.4%. The DICE coefficients of left lung, right lung, heart, liver, spleen, pancreas, left kidney, right kidney, and gallbladder were 0.91, 0.95, 0.77, 0.81, 0.74, 0.08, 0.83, 0.84, and 0.03, respectively.

Improved Seam-Line Searching Algorithm for UAV Image Mosaic with Optical Flow

PubMed Central

Zhang, Weilong; Guo, Bingxuan; Liao, Xuan; Li, Wenzhuo

2018-01-01

Ghosting and seams are two major challenges in creating unmanned aerial vehicle (UAV) image mosaic. In response to these problems, this paper proposes an improved method for UAV image seam-line searching. First, an image matching algorithm is used to extract and match the features of adjacent images, so that they can be transformed into the same coordinate system. Then, the gray scale difference, the gradient minimum, and the optical flow value of pixels in adjacent image overlapped area in a neighborhood are calculated, which can be applied to creating an energy function for seam-line searching. Based on that, an improved dynamic programming algorithm is proposed to search the optimal seam-lines to complete the UAV image mosaic. This algorithm adopts a more adaptive energy aggregation and traversal strategy, which can find a more ideal splicing path for adjacent UAV images and avoid the ground objects better. The experimental results show that the proposed method can effectively solve the problems of ghosting and seams in the panoramic UAV images. PMID:29659526

Implementing Intervention Movement Programs for Kindergarten Children

ERIC Educational Resources Information Center

Deli, Eleni; Bakle, Iliana; Zachopoulou, Evridiki

2006-01-01

The reported study aimed to identify the effects of two 10-week intervention programs on fundamental locomotor skill performance in kindergarten children. Seventy-five children with mean age 5.4 plus or minus 0.5 years participated. Experimental Group A followed a movement program, experimental Group B followed a music and movement program, and…

Experimental Programs and Programmatic Experiments.

ERIC Educational Resources Information Center

Kent, Robert

When assembling or evaluating experimental programs in college English, the crucial fact to be remembered is that the success of the undertaking depends more on the teachers than on the program itself, for it is men, not programs, who fail in the constant experiment with books. Teachers need to be adventurous, constantly rereading, rethinking, and…

The Development and Experimental Analysis of a Self-Instructional Program in Graphical Kinematics.

ERIC Educational Resources Information Center

Nee, John G.

A project to help vocational-technical teachers in the development and experimental analysis of self-instructional programs is presented. The emphasis in developing the program was on maximizing effectiveness and efficiency of program-learner interaction as measured by criterion items. These items emphasized cognitive content dealing with the…

Effect of an empowerment-based nutrition promotion program on food consumption and serum lipid levels in hyperlipidemic Thai elderly.

PubMed

Boonyasopun, Umaporn; Aree, Patcharaporn; Avant, Kay C

2008-06-01

This quasi-experimental study examined the effects of an empowerment-based nutrition promotion program on food consumption and serum lipid levels among hyperlipidemic Thai elderly. Fifty-six experimental subjects received the program; 48 control subjects maintained their habitual lifestyle. The statistical methods used were the t-test, Z-test, and chi2/Fisher's exact test. After the program, the consumption of high saturated fat, cholesterol, and simple sugar diets was significantly lower for the experimental group than for the control group. The percentage change of the serum total cholesterol of the experimental subjects was significantly higher than that of the control subjects. The number of experimental subjects that changed from hyperlipidemia to normolipidemia significantly increased compared to that for the control subjects. The implementation of this program was related to an improvement in food consumption and serum lipid levels among hyperlipidemic Thai elderly and, therefore, has implications for practice.

Parallelized Seeded Region Growing Using CUDA

PubMed Central

Park, Seongjin; Lee, Hyunna; Seo, Jinwook; Lee, Kyoung Ho; Shin, Yeong-Gil; Kim, Bohyoung

2014-01-01

This paper presents a novel method for parallelizing the seeded region growing (SRG) algorithm using Compute Unified Device Architecture (CUDA) technology, with intention to overcome the theoretical weakness of SRG algorithm of its computation time being directly proportional to the size of a segmented region. The segmentation performance of the proposed CUDA-based SRG is compared with SRG implementations on single-core CPUs, quad-core CPUs, and shader language programming, using synthetic datasets and 20 body CT scans. Based on the experimental results, the CUDA-based SRG outperforms the other three implementations, advocating that it can substantially assist the segmentation during massive CT screening tests. PMID:25309619

Photonic Programmable Tele-Cloning Network

PubMed Central

Li, Wei; Chen, Ming-Cheng

2016-01-01

The concept of quantum teleportation allows an unknown quantum states to be broadcasted and processed in a distributed quantum network. The quantum information injected into the network can be diluted to distant multi-copies by quantum cloning and processed by arbitrary quantum logic gates which were programed in advance in the network quantum state. A quantum network combines simultaneously these fundamental quantum functions could lead to new intriguing applications. Here we propose a photonic programmable telecloning network based on a four-photon interferometer. The photonic network serves as quantum gate, quantum cloning and quantum teleportation and features experimental advantage of high brightness by photon recycling. PMID:27353838

On the predictions of the 11B solid state NMR parameters

NASA Astrophysics Data System (ADS)

Czernek, Jiří; Brus, Jiří

2016-07-01

The set of boron containing compounds has been subject to the prediction of the 11B solid state NMR spectral parameters using DFT-GIPAW methods properly treating the solid phase effects. The quantification of the differences between measured and theoretical values has been presented, which is directly applicable in structural studies involving 11B nuclei. In particular, a simple scheme has been proposed, which is expected to provide for an estimate of the 11B chemical shift within ±2.0 ppm from the experimental value. The computer program, INFOR, enabling the visualization of concomitant Euler rotations related to the tensorial transformations has been presented.

The challenge to unify treatment of high-temperature fatigue - A partisan proposal based on strainrange partitioning

NASA Technical Reports Server (NTRS)

Manson, S. S.

1972-01-01

The strainrange partitioning concept divides the imposed strain into four basic ranges involving time-dependent and time-independent components. It is shown that some of the results presented at the symposium can be better correlated on the basis of this concept than by alternative methods. It is also suggested that methods of data generation and analysis can be helpfully guided by this approach. Potential applicability of the concept to the treatment of frequency and hold-time effects, environmental influence, crack initiation and growth, thermal fatigue, and code specifications are briefly considered. A required experimental program is outlined.

The laboratory astrophysics facility at University College

NASA Astrophysics Data System (ADS)

Hyland, A. R.; Smith, R. G.; Robinson, G.

A laboratory astrophysics facility for the study of the terrestrial analogues of interstellar dust grains is being developed in the Physics Department, University College, Australian Defence Force Academy. The facility consists of a gas handling system for the preparation of samples, a closed-cycle cooler and specimen chamber, and a Fourier Transform Infrared (FTIR) Spectrometer capable of high resolution (0.3/cm) and high sensitivity measurements, currently from 1-25 microns. The layout and construction of the laboratory are described, and the proposed initial experimental program aimed at determining the optical constants of ices, over a wide wavelength range for comparison with astronomical observations, is discussed.

Dimensionality effects in chalcogenide-based devices

NASA Astrophysics Data System (ADS)

Kostylev, S. A.

2013-06-01

The multiplicity of fundamental bulk effects with small characteristic dimensions and short times and diversity of their combinations attracts a lot of researcher and industrialist attention in nanoelectronics and photonics to chalcogenide materials. Experimental data presented on dimensional effects of electrical chalcogenide switching (threshold voltage and threshold current dependence on device area and the film thickness), and in phase-change memory (switching, programming and read parameters), are analyzed from the point of view of choice of low dimensional materials with S-NDC and participation of electrical instabilities - high current density filaments. New ways of improving parameters of phase-change devices are proposed together with new criteria of material choice.

Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarillo-Herrero, Pablo

This is the final report of our research program on electronic transport experiments on Topological Insulator (TI) devices, funded by the DOE Office of Basic Energy Sciences. TI-based electronic devices are attractive as platforms for spintronic applications, and for detection of emergent properties such as Majorana excitations , electron-hole condensates , and the topological magneto-electric effect . Most theoretical proposals envision geometries consisting of a planar TI device integrated with materials of distinctly different physical phases (such as ferromagnets and superconductors). Experimental realization of physics tied to the surface states is a challenge due to the ubiquitous presence of bulkmore » carriers in most TI compounds as well as degradation during device fabrication.« less

77 FR 30305 - Notice of Proposed Information Collection; Comment Request Housing Counseling Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... Information Collection; Comment Request Housing Counseling Program AGENCY: Office of the Assistant Secretary... information: Title of Proposal: Housing Counseling Program. OMB Control Number, if applicable: 2502-0261. Description of the need for the information and proposed use: Nonprofit Housing Counseling organizations...

78 FR 1916 - 30-Day Notice of Proposed Information Collection: Smart Traveler Enrollment Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... DEPARTMENT OF STATE [Public Notice 8147] 30-Day Notice of Proposed Information Collection: Smart Traveler Enrollment Program ACTION: Notice of request for public comment and submission to OMB of proposed....gov . SUPPLEMENTARY INFORMATION: Title of Information Collection: Smart Traveler Enrollment Program...

FY 2016 Grant Announcement: FY 2016 Technical Analysis and Programmatic Evaluation Support to the Chesapeake Bay Program Partnership

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency’s Chesapeake Bay Program Office is announcing a Request for Proposals for applicants to provide the Chesapeake Bay Program partners with a proposal(s) for providing technical analysis and programmatic evaluation

SICONID: a FORTRAN-77 program for conditional simulation in one dimension

NASA Astrophysics Data System (ADS)

Pardo-Igúzquiza, E.; Chica-Olmo, M.; Delgado-García, J.

1992-07-01

The SICONID program, written in FORTRAN 77 for the conditional simulation of geological variables in one dimension, is presented. The program permits all the necessary steps to obtain a simulated series of the experimental data to be carried out. These states are: acquisition of the experimental values, modelization of the anamorphosis function, variogram of the normal scores, conditional simulation, and restoration of the experimental histogram. A practical case of simulation of the evolution of the groundwater level in a survey to show the operation of the program is given.

An LMS Programming Scheme and Floating-Gate Technology Enabled Trimmer-Less and Low Voltage Flame Detection Sensor.

PubMed

Iglesias-Rojas, Juan Carlos; Gomez-Castañeda, Felipe; Moreno-Cadenas, Jose Antonio

2017-06-14

In this paper, a Least Mean Square (LMS) programming scheme is used to set the offset voltage of two operational amplifiers that were built using floating-gate transistors, enabling a 0.95 V RMS trimmer-less flame detection sensor. The programming scheme is capable of setting the offset voltage over a wide range of values by means of electron injection. The flame detection sensor consists of two programmable offset operational amplifiers; the first amplifier serves as a 26 μV offset voltage follower, whereas the second amplifier acts as a programmable trimmer-less voltage comparator. Both amplifiers form the proposed sensor, whose principle of functionality is based on the detection of the electrical changes produced by the flame ionization. The experimental results show that it is possible to measure the presence of a flame accurately after programming the amplifiers with a maximum of 35 LMS-algorithm iterations. Current commercial flame detectors are mainly used in absorption refrigerators and large industrial gas heaters, where a high voltage AC source and several mechanical trimmings are used in order to accurately measure the presence of the flame.

An LMS Programming Scheme and Floating-Gate Technology Enabled Trimmer-Less and Low Voltage Flame Detection Sensor

PubMed Central

Iglesias-Rojas, Juan Carlos; Gomez-Castañeda, Felipe; Moreno-Cadenas, Jose Antonio

2017-01-01

In this paper, a Least Mean Square (LMS) programming scheme is used to set the offset voltage of two operational amplifiers that were built using floating-gate transistors, enabling a 0.95 VRMS trimmer-less flame detection sensor. The programming scheme is capable of setting the offset voltage over a wide range of values by means of electron injection. The flame detection sensor consists of two programmable offset operational amplifiers; the first amplifier serves as a 26 μV offset voltage follower, whereas the second amplifier acts as a programmable trimmer-less voltage comparator. Both amplifiers form the proposed sensor, whose principle of functionality is based on the detection of the electrical changes produced by the flame ionization. The experimental results show that it is possible to measure the presence of a flame accurately after programming the amplifiers with a maximum of 35 LMS-algorithm iterations. Current commercial flame detectors are mainly used in absorption refrigerators and large industrial gas heaters, where a high voltage AC source and several mechanical trimmings are used in order to accurately measure the presence of the flame. PMID:28613250

Effects of Partner's Improvisational Resistance Training on dancers' muscular strength.

PubMed

Vetter, Rheba E; Dorgo, Sandor

2009-05-01

The purpose of this study was to observe the effects of Partner's Improvisational Resistance Training (PIRT) on muscular strength, body circumference, and body fat percentage in 10 female college-age dancers in comparison with 8 female dancers in a control group. The PIRT program, based on the concepts of manual resistance training, is the application of contact improvisation in a systematic strength development program, which proposes a way of contextualizing muscular strength development within the dance class. The program lasted 8 weeks, meeting 3 times weekly for 60-minute sessions. The muscular strength pre- and posttests included 1-repetition maximum (1RM) for leg extension, leg flexion, leg press, bench press, lat pulldown, back extension, and modified sit-up. Hydrostatic weighing for body composition and circumference measures on the waist, hip, shoulder, upper arm, and thigh were made pre- and posttest analyses. There were no significant pretest differences between the groups for age, height, body weight, body fat percentage, any of the circumference measures, or 5 of the 7 muscular strength measures. At posttest, neither group showed significant changes in total body weight, body fat percentage, or lean body weight. The experimental group showed significant decrements in the waist and hip circumference measures, and all other body circumference changes were nonsignificant. The experimental group showed significant changes from pretest to posttest for all seven 1RM strength measures and greater absolute and relative strength improvements in 5 measures compared with the control group. Thus, the 8-week PIRT program for female dancers was found effective in improving overall muscular strength and decreasing circumference in the waist-hip region, but it did not elicit significant changes in body composition.

The NSF IUSE-EHR Program: What's New (and Old) About It, and Resources for Geoscience Proposers

NASA Astrophysics Data System (ADS)

Singer, J.; Ryan, J. G.

2015-12-01

The NSF Division of Undergraduate Education recently released a new solicitation for the IUSE program -- the latest iteration in a succession of funding programs dating back over 30 years (including the Instrumentation and Laboratory Improvement Program (ILI), the Course and Curriculum Development Program (CCD), the Course Curriculum and Laboratory Improvement Program (CCLI), and the Transforming Undergraduate STEM Education Program (TUES). All of these programs sought/seek to support high quality STEM education for majors and non-majors in lower- and upper-division undergraduate courses. The current IUSE-EHR program is described in a 2-year solicitation that includes two tracks: Engaged Student Learning, and Institutional & Community Transformation. Each track has several options for funding level and project duration. A wide range of activities can be proposed for funding, and the program recognizes the varying needs across STEM disciplines. Geoscientists and other potential IUSE proposers are strongly encouraged to form collaborations with colleagues that conduct educational research and to propose projects that build upon the educational knowledge base in the discipline as well as contribute to it. Achieving this may not be immediately obvious to many geoscientists who have interests in improving student learning in their courses, but are not fluent in the scholarship of education in their field. To lower the barriers that have historically prevented larger numbers of geoscientists from developing their ideas into competitive education-related proposals, we have explored strategies for building and leveraging partnerships, sought to identify available resources for proposers, and explored a range of strategies for engaging and supporting larger numbers of potential geoscience proposers.

Small-scale multi-axial hybrid simulation of a shear-critical reinforced concrete frame

NASA Astrophysics Data System (ADS)

Sadeghian, Vahid; Kwon, Oh-Sung; Vecchio, Frank

2017-10-01

This study presents a numerical multi-scale simulation framework which is extended to accommodate hybrid simulation (numerical-experimental integration). The framework is enhanced with a standardized data exchange format and connected to a generalized controller interface program which facilitates communication with various types of laboratory equipment and testing configurations. A small-scale experimental program was conducted using a six degree-of-freedom hydraulic testing equipment to verify the proposed framework and provide additional data for small-scale testing of shearcritical reinforced concrete structures. The specimens were tested in a multi-axial hybrid simulation manner under a reversed cyclic loading condition simulating earthquake forces. The physical models were 1/3.23-scale representations of a beam and two columns. A mixed-type modelling technique was employed to analyze the remainder of the structures. The hybrid simulation results were compared against those obtained from a large-scale test and finite element analyses. The study found that if precautions are taken in preparing model materials and if the shear-related mechanisms are accurately considered in the numerical model, small-scale hybrid simulations can adequately simulate the behaviour of shear-critical structures. Although the findings of the study are promising, to draw general conclusions additional test data are required.

Optimizing Retransmission Threshold in Wireless Sensor Networks

PubMed Central

Bi, Ran; Li, Yingshu; Tan, Guozhen; Sun, Liang

2016-01-01

The retransmission threshold in wireless sensor networks is critical to the latency of data delivery in the networks. However, existing works on data transmission in sensor networks did not consider the optimization of the retransmission threshold, and they simply set the same retransmission threshold for all sensor nodes in advance. The method did not take link quality and delay requirement into account, which decreases the probability of a packet passing its delivery path within a given deadline. This paper investigates the problem of finding optimal retransmission thresholds for relay nodes along a delivery path in a sensor network. The object of optimizing retransmission thresholds is to maximize the summation of the probability of the packet being successfully delivered to the next relay node or destination node in time. A dynamic programming-based distributed algorithm for finding optimal retransmission thresholds for relay nodes along a delivery path in the sensor network is proposed. The time complexity is OnΔ·max1≤i≤n{ui}, where ui is the given upper bound of the retransmission threshold of sensor node i in a given delivery path, n is the length of the delivery path and Δ is the given upper bound of the transmission delay of the delivery path. If Δ is greater than the polynomial, to reduce the time complexity, a linear programming-based (1+pmin)-approximation algorithm is proposed. Furthermore, when the ranges of the upper and lower bounds of retransmission thresholds are big enough, a Lagrange multiplier-based distributed O(1)-approximation algorithm with time complexity O(1) is proposed. Experimental results show that the proposed algorithms have better performance. PMID:27171092

Automatic identification of epileptic seizures from EEG signals using linear programming boosting.

PubMed

Hassan, Ahnaf Rashik; Subasi, Abdulhamit

2016-11-01

Computerized epileptic seizure detection is essential for expediting epilepsy diagnosis and research and for assisting medical professionals. Moreover, the implementation of an epilepsy monitoring device that has low power and is portable requires a reliable and successful seizure detection scheme. In this work, the problem of automated epilepsy seizure detection using singe-channel EEG signals has been addressed. At first, segments of EEG signals are decomposed using a newly proposed signal processing scheme, namely complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). Six spectral moments are extracted from the CEEMDAN mode functions and train and test matrices are formed afterward. These matrices are fed into the classifier to identify epileptic seizures from EEG signal segments. In this work, we implement an ensemble learning based machine learning algorithm, namely linear programming boosting (LPBoost) to perform classification. The efficacy of spectral features in the CEEMDAN domain is validated by graphical and statistical analyses. The performance of CEEMDAN is compared to those of its predecessors to further inspect its suitability. The effectiveness and the appropriateness of LPBoost are demonstrated as opposed to the commonly used classification models. Resubstitution and 10 fold cross-validation error analyses confirm the superior algorithm performance of the proposed scheme. The algorithmic performance of our epilepsy seizure identification scheme is also evaluated against state-of-the-art works in the literature. Experimental outcomes manifest that the proposed seizure detection scheme performs better than the existing works in terms of accuracy, sensitivity, specificity, and Cohen's Kappa coefficient. It can be anticipated that owing to its use of only one channel of EEG signal, the proposed method will be suitable for device implementation, eliminate the onus of clinicians for analyzing a large bulk of data manually, and expedite epilepsy diagnosis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

76 FR 22437 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals; Community Solutions...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

... complex global challenges related to the participants' community activities. Strong project designs will... program include participation in the design and direction of program implementation including recruitment... Partner Countries: Proposals need to embrace a global program design that incorporates all of the proposed...

76 FR 22913 - Notice of Proposed Information Collection: Comment Request; Emergency Homeowners' Loan Program...

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2011-04-25

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5484-N-13] Notice of Proposed Information Collection: Comment Request; Emergency Homeowners' Loan Program Data Elements AGENCY: Office of... information: Title of Proposal: Emergency Homeowners' Loan Program Data Elements. OMB Control Number, if...

77 FR 9216 - Native American Career and Technical Education Program; Proposed Waivers and Extension of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... DEPARTMENT OF EDUCATION Native American Career and Technical Education Program; Proposed Waivers... Education, Department of Education. ACTION: Notice. SUMMARY: For 60-month projects funded in fiscal year (FY) 2007 under the Native American Career and Technical Education Program (NACTEP), the Secretary proposes...

77 FR 3787 - Notice of Submission of Proposed Information Collection to OMB; Family Unification Program (FUP)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... Proposed Information Collection to OMB; Family Unification Program (FUP) AGENCY: Office of the Chief... Paperwork Reduction Act. The Department is soliciting public comments on the subject proposal. Application for the Family Unification Program: Makes Housing Choice Vouchers available to eligible families to...

76 FR 11505 - Notice of Submission of Proposed Information Collection to OMB Family Unification Program (FUP)

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2011-03-02

... Proposed Information Collection to OMB Family Unification Program (FUP) AGENCY: Office of the Chief... Paperwork Reduction Act. The Department is soliciting public comments on the subject proposal. Application for the Family Unification Program: Makes Housing Choice Vouchers available to eligible families to...

78 FR 7437 - Proposed Collection; Comment Request (60-Day FRN); The Clinical Trials Reporting Program (CTRP...

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2013-02-01

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USGS Workshop on Scientific Aspects of a Long-Term Experimental Plan for Glen Canyon Dam, April 10-11, 2007, Flagstaff, Arizona

USGS Publications Warehouse

,

2008-01-01

Executive Summary Glen Canyon Dam is located in the lower reaches of Glen Canyon National Recreation Area on the Colorado River, approximately 15 miles upriver from Grand Canyon National Park (fig. 1). In 1992, Congress passed and the President signed into law the Grand Canyon Protection Act (GCPA; title XVIII, sec. 1801?1809, of Public Law 102-575), which seeks ?to protect, mitigate adverse impacts to, and improve the values for which Grand Canyon National Park and Glen Canyon National Recreation Area were established.? The Glen Canyon Dam Adaptive Management Program (GCDAMP) was implemented as a result of the 1996 Record of Decision on the Operation of Glen Canyon Dam Final Environmental Impact Statement to ensure that the primary mandate of the GCPA is met through advances in information and resources management (U.S. Department of the Interior, 1995). On November 3, 2006, the Bureau of Reclamation (Reclamation) announced it would develop a long-term experimental plan environmental impact statement (LTEP EIS) for operational activities at Glen Canyon Dam and other management actions on the Colorado River. The purpose of the long-term experimental plan is twofold: (1) to increase the scientific understanding of the ecosystem and (2) to improve and protect important downstream resources. The proposed plan would implement a structured, longterm program of experimentation to include dam operations, potential modifications to Glen Canyon Dam intake structures, and other management actions such as removal of nonnative fish species. The development of the long-term experimental plan continues efforts begun by the GCDAMP to protect resources downstream of Glen Canyon Dam, including Grand Canyon, through adaptive management and scientific experimentation. The LTEP EIS will rely on the extensive scientific studies that have been undertaken as part of the adaptive management program by the U.S. Geological Survey?s (USGS) Grand Canyon Monitoring and Research Center (GCMRC), one of the four research stations within the USGS Southwest Biological Science Center. On April 10 and 11, 2007, at the behest of Reclamation, the GCMRC convened a workshop with scientific experts to identify one or more scientifically credible, long-term experimental options for Reclamation to consider for the LTEP EIS that would be consistent with the purpose and need for the plan. Workshop participants included government, academic, and private scientists with broad experience in the Colorado River in Grand Canyon and regulated rivers around the world. Resource managers and GCDAMP participants were also present on the second day of the workshop. In advance of the workshop, Reclamation and LTEP EIS cooperating agencies identified 14 core scientific questions. Workshop participants were asked to consider how proposed options would address these questions, which fall primarily into four areas: (1) conservation of endangered humpback chub (Gila cypha) and other high-priority biological resources, (2) conservation of sediment resources, (3) enhancement of recreational resources, and (4) preservation of cultural resources. A secondary objective of the workshop was the evaluation of four long-term experimental options developed by the GCDAMP Science Planning Group (SPG) (appendix B). The flow and nonflow treatments called for in the four experimental options were an important starting point for workshop discussions. At the beginning of the workshop, participants were provided with the final LTEP EIS scoping report prepared by Reclamation. Participants were also advised that Reclamation had committed to ?make every effortEto ensure that a new population of humpback chub is established in the mainstem or one or more of the tributaries within Grand Canyon? in the 1995 Operation of Glen Canyon Dam Final Environmental Impact Statement (U.S. Department of the Interior, 1995). This decision was consistent with the U.S. Fish and Wildlife Service?s 1995 bi

47 CFR 73.1510 - Experimental authorizations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Experimental authorizations. 73.1510 Section 73... conducted at any time the station is authorized to operate, but the minimum required schedule of programming... regularly scheduled programming concurrently with the experimental transmission if there is no significant...

47 CFR 73.1510 - Experimental authorizations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Experimental authorizations. 73.1510 Section 73... conducted at any time the station is authorized to operate, but the minimum required schedule of programming... regularly scheduled programming concurrently with the experimental transmission if there is no significant...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yokosawa, Akihiko

Experimental results are reviewed on polarization phenomena in nucleon-nucleon scattering at intermediate energies. The present status of S = 0 dibaryon resonances is presented. The status of the Fermilab polarized beam program is presented, including the construction of polarized beam, two polarimeters being installed in the experimental hall, and the experimental program. (LEW)

Fusion and Sense Making of Heterogeneous Sensor Network and Other Sources

DTIC Science & Technology

2017-03-16

multimodal fusion framework that uses both training data and web resources for scene classification, the experimental results on the benchmark datasets...show that the proposed text-aided scene classification framework could significantly improve classification performance. Experimental results also show...human whose adaptability is achieved by reliability- dependent weighting of different sensory modalities. Experimental results show that the proposed

Romanian MRE Rocket Engines Program - An Early Endeavor

NASA Astrophysics Data System (ADS)

Rugescu, R. E.

2002-01-01

(MRE) was initiated in the years '60 of the past century at the Chair of Aerospace Sciences "Elie Carafoli" from the "Politehnica" University in Bucharest (PUB). Consisting of theoretical and experimental investigations in the form of computational methods and technological solutions for small size MRE-s and the concept of the test stand for these engines, the program ended in the construction of the first Romanian liquid rocket motors. Hermann Oberth and Dorin Pavel, were known from 1923, no experimental practice was yet tempted, at the time level of 1960. It was the intention of the developers at PUB to cover this gap and initiate a feasible, low-cost, demonstrative program of designing and testing experimental models of MRE. The research program was oriented towards future development of small size space carrier vehicles for scientific applications only, as an independent program with no connection to other defense programs imagined by the authorities in Bucharest, at that time. Consequently the entire financial support was assured by "Politehnica" university. computerized methods in the thermochemistry of heterogeneous combustion, for both steady and unsteady flows with chemical reactions and two phase flows. The research was gradually extended to the production of a professional CAD program for steady-state heat transfer simulations and the loading capacity analyses of the double wall, cooled thrust chamber. The resulting computer codes were run on a 360-30 IMB machine, beginning in 1968. Some of the computational methods were first exposed at the 9th International Conference on Applied Mechanics, held in Bucharest between June 23-27, 1969. hot testing of a series of storable propellant, variable thrust, variable geometry, liquid rocket motors, with a maximal thrust of 200N. A remotely controlled, portable test bad, actuated either automatically or manually and consisting of a 6-modules construction was built for this motor series, with a simple 8 analog-channel and 5 digital-channel data measuring and recording system. The first hot test firing of the MRE-1B motor took place successfully on April 9th, 1969 in Bucharest, at the "Elie Carafoli" Chair of UPB. The research program continued with the development of a series of solid, double base propellant rocket and ram-rocket motors, with emphasize on the optimization of the gasdynamic contour of the engine, in order to increase the flight performances. Increments of up to 8% in specific thrust were measured on the test stand, with mass savings and no extra costs. The test firing of the first Romanian, air-breathing ram-rocket engine took place successfully in august 1987 at the Chemical Works in Fagaras, Romania. Astronautics", founded in Bucharest. The principles and history of the "MRE" research program are presented in the proposed paper.

76 FR 42169 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-18

...This proposed rule would revise the Medicare hospital outpatient prospective payment system (OPPS) to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this proposed rule, we describe the proposed changes to the amounts and factors used to determine the payment rates for Medicare hospital outpatient services paid under the OPPS. These proposed changes would be applicable to services furnished on or after January 1, 2012. In addition, this proposed rule would update the revised Medicare ambulatory surgical center (ASC) payment system to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this proposed rule, we set forth the proposed relative payment weights and payment amounts for services furnished in ASCs, specific HCPCS codes to which these proposed changes would apply, and other proposed ratesetting information for the CY 2012 ASC payment system. These proposed changes would be applicable to services furnished on or after January 1, 2012. We are proposing to revise the requirements for the Hospital Outpatient Quality Reporting (IQR) Program, add new requirements for ASC Quality Reporting System, and make additional changes to provisions of the Hospital Inpatient Value-Based Purchasing (VBP) Program. We also are proposing to allow eligible hospitals and CAHs participating in the Medicare Electronic Health Record (EHR) Incentive Program to meet the clinical quality measure reporting requirement of the EHR Incentive Program for payment year 2012 by participating in the 2012 Medicare EHR Incentive Program Electronic Reporting Pilot. In addition, we are proposing to make changes to the rules governing the whole hospital and rural provider exceptions to the physician self-referral prohibition for expansion of facility capacity and changes to provider agreement regulations on patient notification requirements.

An Update on the NASA Planetary Science Division Research and Analysis Program

NASA Astrophysics Data System (ADS)

Richey, Christina; Bernstein, Max; Rall, Jonathan

2015-01-01

Introduction: NASA's Planetary Science Division (PSD) solicits its Research and Analysis (R&A) programs each year in Research Opportunities in Space and Earth Sciences (ROSES). Beginning with the 2014 ROSES solicitation, PSD will be changing the structure of the program elements under which the majority of planetary science R&A is done. Major changes include the creation of five core research program elements aligned with PSD's strategic science questions, the introduction of several new R&A opportunities, new submission requirements, and a new timeline for proposal submissionROSES and NSPIRES: ROSES contains the research announcements for all of SMD. Submission of ROSES proposals is done electronically via NSPIRES: http://nspires.nasaprs.com. We will present further details on the proposal submission process to help guide younger scientists. Statistical trends, including the average award size within the PSD programs, selections rates, and lessons learned, will be presented. Information on new programs will also be presented, if available.Review Process and Volunteering: The SARA website (http://sara.nasa.gov) contains information on all ROSES solicitations. There is an email address (SARA@nasa.gov) for inquiries and an area for volunteer reviewers to sign up. The peer review process is based on Scientific/Technical Merit, Relevance, and Level of Effort, and will be detailed within this presentation.ROSES 2014 submission changes: All PSD programs will use a two-step proposal submission process. A Step-1 proposal is required and must be submitted electronically by the Step-1 due date. The Step-1 proposal should include a description of the science goals and objectives to be addressed by the proposal, a brief description of the methodology to be used to address the science goals and objectives, and the relevance of the proposed research to the call submitted to.Additional Information: Additional details will be provided on the Cassini Data Analysis Program, the Exoplanets Research program and Discovery Data Analysis Program, for which Dr. Richey is the Lead Program Officer.

SHEEP AS AN EXPERIMENTAL MODEL FOR BIOMATERIAL IMPLANT EVALUATION

PubMed Central

SARTORETTO, SUELEN CRISTINA; UZEDA, MARCELO JOSÉ; MIGUEL, FÚLVIO BORGES; NASCIMENTO, JHONATHAN RAPHAELL; ASCOLI, FABIO; CALASANS-MAIA, MÔNICA DIUANA

2016-01-01

ABSTRACT Objective: Based on a literature review and on our own experience, this study proposes sheep as an experimental model to evaluate the bioactive capacity of bone substitute biomaterials, dental implant systems and orthopedics devices. The literature review covered relevant databases available on the Internet from 1990 until to date, and was supplemented by our own experience. Methods: For its resemblance in size and weight to humans, sheep are quite suitable for use as an experimental model. However, information about their utility as an experimental model is limited. The different stages involving sheep experiments were discussed, including the care during breeding and maintenance of the animals obtaining specimens for laboratory processing, and highlighting the unnecessary euthanasia of animals at the end of study, in accordance to the guidelines of the 3Rs Program. Results: All experiments have been completed without any complications regarding the animals and allowed us to evaluate hypotheses and explain their mechanisms. Conclusion: The sheep is an excellent animal model for evaluation of biomaterial for bone regeneration and dental implant osseointegration. From an ethical point of view, one sheep allows for up to 12 implants per animal, permitting to keep them alive at the end of the experiments. Level of Evidence II, Retrospective Study. PMID:28149193

Evaluating an Experimental Audio-Visual Module Programmed to Teach a Basic Anatomical and Physiological System.

ERIC Educational Resources Information Center

Federico, Pat-Anthony

The learning efficiency and effectiveness of teaching an anatomical and physiological system to Air Force enlisted trainees utilizing an experimental audiovisual programed module was compared to that of a commercial linear programed text. It was demonstrated that the audiovisual programed approach to training was more efficient than and equally as…

Impact of the Siena College Tech Valley Scholars Program on Student Outcomes

ERIC Educational Resources Information Center

Medsker, Larry; Allard, Lee; Tucker, Lucas J.; O'Donnell, Jodi L.; Sterne-Marr, Rachel; Bannon, Jon; Finn, Rose; Weatherwax, Allan

2016-01-01

The Tech Valley Scholars (TVS) program included 38 students who joined this program over the course of three academic years, from 2009 to 2012. These students comprise the experimental group for this study to determine if participating in the NSF-funded Tech Valley Scholars program improved academic outcomes. The experimental group was compared to…

CY2013 Annual Report for DOE-ITU INERI 2010-006-E

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, J. Rory; Rondinella, Vincenzo V.

2014-12-01

New concepts for nuclear energy development are considered in both the USA and Europe within the framework of the Generation-IV International Forum (GIF) as well as in various US-DOE programs (e.g. the Fuel Cycle Research and Development - FCRD) and as part of the European Sustainable Nuclear Energy Technology Platform (SNE-TP). Since most new fuel cycle concepts envisage the adoption of a closed nuclear fuel cycle employing fast reactors, the fuel behavior characteristics of the various proposed advanced fuel forms must be effectively investigated using state of the art experimental techniques before implementation. More rapid progress can be achieved ifmore » effective synergy with advanced (multi-scale) modeling efforts can be achieved. The fuel systems to be considered include minor actinide (MA) transmutation fuel types such as advanced MOX, advanced metal alloy, inert matrix fuel (IMF), and other ceramic fuels like nitrides, carbides, etc., for fast neutronic spectrum conditions. Most of the advanced fuel compounds have already been the object of past examination programs, which included irradiations in research reactors. The knowledge derived from previous experience constitutes a significant, albeit incomplete body of data. New or upgraded experimental tools are available today that can extend the scientific and technological knowledge towards achieving the objectives associated with the new generation of nuclear reactors and fuels. The objectives of this project will be three-fold: (1) to extend the available knowledge on properties and irradiation behavior of high burnup and minor actinide bearing advanced fuel systems; (2) to establish a synergy with multi-scale and code development efforts in which experimental data and expertise on the irradiation behavior of nuclear fuels is properly conveyed for the upgrade/development of advanced modeling tools; (3) to promote the effective use of international resources to the characterization of irradiated fuel through exchange of expertise and information among leading experimental facilities. The priorities in this project will be set according to the down selection procedure of U.S. and European development programs.« less

Early differentiation of the Moon: Experimental and modeling studies and experimental and modeling studies of massif anorthosites

NASA Technical Reports Server (NTRS)

Longhi, John

1994-01-01

NASA grant NAG9-329 was in effect from 3/1/89 to 8/31/94, the last 18 months being a no-cost extension. While the grant was in effect, the P.I., coworkers, and students gave 22 talks and poster sessions at professional meetings, published 12 articles in referred journals (one more is in press, and another is in review), and edited 2 workshop reports relevant to this project. Copies of all the publications are appended to this report. The major accomplishments during the grant period have derived from three quarters: 1) the application of quantitative models of fractional crystallization and partial melting to various problems in planetary science, such as the petrogenesis of picritic glasses and mare basalts and the implications of the SNC meteorites for martian evolution; 2) an experimental study of silicate liquid immiscibility relevant to early lunar differentiation and the petrogenesis of evolved highlands rocks; and 3) experimental studies of massif anorthosites and related rocks that provide terrestrial analogs for the proposed origin of lunar anorthosites by multistage processes. The low-pressure aspects of the quantitative models were developed by the P.I. in the 1980s with NASA support and culminated with a paper comparing the crystallization of terrestrial and lunar lavas. The basis for the high-pressure modifications to the quantitative models is a data set gleaned from high pressure melting experiments done at Lamont and is supplemented by published data from other labs that constrain the baric and compositional dependences of various liquidus phase boundaries such as olivine/orthopyroxene, relevant to the melting of the mantles of the terrestrial planets. With these models it is possible to predict not only the thermal and compositional evolution of magmatic liquids ranging in composition from lumar mare basalt to terrestrial calc-alkaline basalts, but also the small increments of fractional melting that are produced when mantle rises adiabatically. Copies of the crystallization/melting programs have been given to several colleagues in planetary science. Additionally, a series of computer graphics programs, based on the algorithms in the crystallization programs have been developed that display liquidus diagrams appropriate to input compositions.

Survey of engineering computational methods and experimental programs for estimating supersonic missile aerodynamic characteristics

NASA Technical Reports Server (NTRS)

Sawyer, W. C.; Allen, J. M.; Hernandez, G.; Dillenius, M. F. E.; Hemsch, M. J.

1982-01-01

This paper presents a survey of engineering computational methods and experimental programs used for estimating the aerodynamic characteristics of missile configurations. Emphasis is placed on those methods which are suitable for preliminary design of conventional and advanced concepts. An analysis of the technical approaches of the various methods is made in order to assess their suitability to estimate longitudinal and/or lateral-directional characteristics for different classes of missile configurations. Some comparisons between the predicted characteristics and experimental data are presented. These comparisons are made for a large variation in flow conditions and model attitude parameters. The paper also presents known experimental research programs developed for the specific purpose of validating analytical methods and extending the capability of data-base programs.

78 FR 68016 - Disadvantaged Business Enterprise: Program Implementation Modifications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... 2105-AE08 Disadvantaged Business Enterprise: Program Implementation Modifications AGENCY: Office of the... to the Department's Disadvantaged Business Enterprise (DBE) program found in the Notice of Proposed... notice of proposed rulemaking (NPRM) entitled, ``Disadvantaged Business Enterprise: Program...

[Effects of a Facial Muscle Exercise Program including Facial Massage for Patients with Facial Palsy].

PubMed

Choi, Hyoung Ju; Shin, Sung Hee

2016-08-01

The purpose of this study was to examine the effects of a facial muscle exercise program including facial massage on the facial muscle function, subjective symptoms related to paralysis and depression in patients with facial palsy. This study was a quasi-experimental research with a non-equivalent control group non-synchronized design. Participants were 70 patients with facial palsy (experimental group 35, control group 35). For the experimental group, the facial muscular exercise program including facial massage was performed 20 minutes a day, 3 times a week for two weeks. Data were analyzed using descriptive statistics, χ²-test, Fisher's exact test and independent sample t-test with the SPSS 18.0 program. Facial muscular function of the experimental group improved significantly compared to the control group. There was no significant difference in symptoms related to paralysis between the experimental group and control group. The level of depression in the experimental group was significantly lower than the control group. Results suggest that a facial muscle exercise program including facial massage is an effective nursing intervention to improve facial muscle function and decrease depression in patients with facial palsy.

A Cosmetic Content-Based Nutrition Education Program Improves Fruit and Vegetable Consumption Among Grade 11 Thai Students.

PubMed

Somsri, Pattraporn; Satheannoppakao, Warapone; Tipayamongkholgul, Mathuros; Vatanasomboon, Paranee; Kasemsup, Rachada

2016-03-01

To examine and compare the effectiveness of a cosmetic content-based nutrition education (CCBNEd) program and a health content-based nutrition education (HCBNEd) program on the promotion of fruit and vegetable (F&V) consumption. Quasi-experimental. Three secondary schools in Nonthaburi, Thailand. Three classes of students were randomly assigned to 3 study groups: experimental group 1 (n = 41) participated in the CCBNEd program, experimental group 2 (n = 35) experienced the HCBNEd program, and a comparison group (n = 37) did not participate in a program. All groups received F&V information. Data were collected between July and September, 2013. Knowledge about F&V, attitude toward F&V consumption, and the amount and variety of F&V consumed were measured at baseline, posttest, and follow-up. Nonparametric statistics were used to compare the programs' effectiveness. After the test, experimental group 1 had significantly increased knowledge scores, attitude scores, and the amount and variety of F&V consumed compared with those at baseline (P < .001). These positive changes were maintained until follow-up. In experimental group 2, knowledge and attitude scores increased (P < .001) at posttest and then decreased at follow-up whereas the comparison group positively changed only in knowledge. The CCBNEd program was most effective at increasing F&V consumption. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

[Effect of school-based peer leader centered smoking prevention program].

PubMed

Shin, Sung Rae; Oh, Pok Ja; Youn, Hye Kyung; Shin, Sun Hwa

2014-12-01

The purpose of this study was to develop and evaluate a school-based peer leader centered smoking prevention program. Non-equivalent control group with a pre/post-test design was used. Students (n=174) in two boys' junior high schools located in D city, Korea participated with 85 being selected for the experimental group and 89 for the control group. Five sessions were given to the experimental group and a 50 minute lecture to the control group. Knowledge, attitude, non-smoking intention, and non-smoking efficacy were measured for the both experimental and control group at two weeks before the program and one month after the program was completed. Data were analyzed using χ²-test, Fisher's exact test, independent t-test and paired t-test with the SPSS 21.0 program. The experimental group showed higher overall knowledge, negative attitude toward smoking, and higher non-smoking intention and efficacy. After receiving the school based peer leader centered smoking prevention program scores for attitude toward smoking and non-smoking efficacy increased in the experimental group were higher than in the control group. The school-based peer leader centered smoking prevention program needs longitudinal evaluation, but from this study, there is an indication that this program can be used with junior high school students and effectively change students' attitude toward smoking and promote non-smoking efficacy.

75 FR 15767 - Livability Initiative under Special Experimental Project No. 14

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

...] Livability Initiative under Special Experimental Project No. 14 AGENCY: Federal Highway Administration (FHWA... initiative to harmonize and coordinate the Federal-aid Highway Program with grant-in- aid programs... (EPA). Under this initiative, the FHWA intends to utilize Special Experimental Project No. 14 (SEP-14...

Adiabatically-controlled two-qubit gates using quantum dot hybrid qubits

NASA Astrophysics Data System (ADS)

Frees, Adam; Gamble, John King; Friesen, Mark; Coppersmith, S. N.

With its recent success in experimentally performing single-qubit gates, the quantum dot hybrid qubit is an excellent candidate for two-qubit gating. Here, we propose an operational scheme which exploits the electrostatic properties of such qubits to yield a tunable effective coupling in a system with a static capacitive coupling between the dots. We then use numerically calculated fidelities to demonstrate the effect of charge noise on single- and two-qubit gates with this scheme. Finally, we show steps towards optimizing the gates fidelities, and discuss ways that the scheme could be further improved. This work was supported in part by ARO (W911NF-12-0607) (W911NF-12-R-0012), NSF (PHY-1104660), ONR (N00014-15-1-0029). The authors gratefully acknowledge support from the Sandia National Laboratories Truman Fellowship Program, which is funded by the Laboratory Directed Research and Development (LDRD) Program. Sandia is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000.

Evaluation of a social marketing campaign targeting preschool children.

PubMed

Johnson, Susan L; Bellows, Laura; Beckstrom, Leslie; Anderson, Jennifer

2007-01-01

To determine the effectiveness of a pilot social marketing program to increase preschoolers' willingness to try new foods. Four Head Start centers participated (2 experimental, 2 control) in a study using a quasi-experimental design. Experimental sites received a 12-week intervention developed using social marketing techniques. The program was evaluated via preference assessments, classroom observations, and teacher surveys. Increased preference for and willingness to try new foods were observed in children from the experimental sites (P<0.05). The program was positively received by Head Start staff. A social marketing campaign is an effective method to reduce children's neophobia.

Grant Success for Early-Career Faculty in Patient-Oriented Research: Difference-in-Differences Evaluation of an Interdisciplinary Mentored Research Training Program.

PubMed

Libby, Anne M; Hosokawa, Patrick W; Fairclough, Diane L; Prochazka, Allan V; Jones, Pamela J; Ginde, Adit A

2016-12-01

Since 2004, the Clinical Faculty Scholars Program (CFSP) at the University of Colorado Anschutz Medical Campus has provided intensive interdisciplinary mentoring and structured training for early-career clinical faculty from multiple disciplines conducting patient-oriented clinical and outcomes research. This study evaluated the two-year program's effects by comparing grant outcomes for CFSP participants and a matched comparison cohort of other junior faculty. Using 2000-2011 institutional grant and employment data, a cohort of 25 scholars was matched to a cohort of 125 comparison faculty (using time in rank and pre-period grant dollars awarded). A quasi-experimental difference-in-differences design was used to identify the CFSP effect on grant outcomes. Grant outcomes were measured by counts and dollars of grant proposals and awards as principal investigator. Outcomes were compared within cohorts over time (pre- vs. post-period) and across cohorts. From pre- to post-period, mean annual counts and dollars of grant awards increased significantly for both cohorts, but mean annual dollars increased significantly more for the CFSP than for the comparison cohort (delta $83,427 vs. $27,343, P < .01). Mean annual counts of grant proposals also increased significantly more for the CFSP than for the comparison cohort: 0.42 to 2.34 (delta 1.91) versus 0.77 to 1.07 (delta 0.30), P < .01. Institutional investment in mentored research training for junior faculty provided significant grant award gains that began after one year of CFSP participation and persisted over time. The CFSP is a financially sustainable program with effects that are predictable, significant, and enduring.

Experimental evaluation of sensorimotor patterning used with mentally retarded children.

PubMed

Neman, R; Roos, P; McCann, R M; Menolascino, F J; Heal, L W

1975-01-01

In the present study, a sensorimotor "patterning" program used with 66 institutionalized, mentally retarded children and adolescents was evaluated. The subjects were randomly assigned to one of three groups: (a) Experimental 1 group, which received a program of mobility exercises including patterning, creeping, and crawling; visual-motor training; and sensory stimulation exercises; (b) Experimental 2 group, which received a program of physical activity, personal attention, and the same sensory stimulation program given to the first group; or (c) Passive Control group, which provided baseline measures but which received no additional programming as part of the study. Experimental 1 group subjects improved more than subjects in the other groups in visual perception, program-related measures of mobility, and language ability. Intellectual functioning did not appear to be enhanced by the procedures, at least during the active phase of the project. The results were discussed with reference to other researchers who have failed to support the patterning approach, and some reasons were suggested for the differences between the present and past investigations.

Directory of research projects, 1991. Planetary geology and geophysics program

NASA Technical Reports Server (NTRS)

Maxwell, Ted A. (Editor)

1991-01-01

Information is provided about currently funded scientific research within the Planetary Geology and Geophysics Program. The directory consists of the proposal summary sheet from each proposal funded by the program during fiscal year 1991. Information is provided on the research topic, principal investigator, institution, summary of research objectives, past accomplishments, and proposed investigators.

76 FR 60854 - Notice of Submission of Proposed Information Collection to OMB; Housing Choice Voucher Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... Proposed Information Collection to OMB; Housing Choice Voucher Program Administrative Fee Study Pretest... the pretest will be used to refine the methodology used for the full study of administrative fees with...: Title of Proposal: Housing Choice Voucher Program Administrative Fee Study Pretest. OMB Approval Number...

Directory of research projects: Planetary geology and geophysics program

NASA Technical Reports Server (NTRS)

Holt, Henry (Editor)

1990-01-01

Information about currently funded scientific research within the Planetary Geology and Geophysics Program is provided, including the proposal summary sheet from each proposal funded under the program during fiscal year 1990. Information about the research project, including title, principal investigator, institution, summary of research objectives, past accomplishments, and proposed new investigations is also provided.

76 FR 34633 - Medicare Program; Proposed Changes to the Hospital Inpatient Prospective Payment Systems for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

....773, Medicare--Hospital Insurance; and Program No. 93.774, Medicare-- Supplementary Medical Insurance... errors in the proposed rule entitled ``Medicare Program; Proposed Changes to the Hospital Inpatient...-9644 of May 5, 2011 (76 FR 25788), there were a number of technical and typographical errors that are...

Online learning control using adaptive critic designs with sparse kernel machines.

PubMed

Xu, Xin; Hou, Zhongsheng; Lian, Chuanqiang; He, Haibo

2013-05-01

In the past decade, adaptive critic designs (ACDs), including heuristic dynamic programming (HDP), dual heuristic programming (DHP), and their action-dependent ones, have been widely studied to realize online learning control of dynamical systems. However, because neural networks with manually designed features are commonly used to deal with continuous state and action spaces, the generalization capability and learning efficiency of previous ACDs still need to be improved. In this paper, a novel framework of ACDs with sparse kernel machines is presented by integrating kernel methods into the critic of ACDs. To improve the generalization capability as well as the computational efficiency of kernel machines, a sparsification method based on the approximately linear dependence analysis is used. Using the sparse kernel machines, two kernel-based ACD algorithms, that is, kernel HDP (KHDP) and kernel DHP (KDHP), are proposed and their performance is analyzed both theoretically and empirically. Because of the representation learning and generalization capability of sparse kernel machines, KHDP and KDHP can obtain much better performance than previous HDP and DHP with manually designed neural networks. Simulation and experimental results of two nonlinear control problems, that is, a continuous-action inverted pendulum problem and a ball and plate control problem, demonstrate the effectiveness of the proposed kernel ACD methods.

Automatic design of synthetic gene circuits through mixed integer non-linear programming.

PubMed

Huynh, Linh; Kececioglu, John; Köppe, Matthias; Tagkopoulos, Ilias

2012-01-01

Automatic design of synthetic gene circuits poses a significant challenge to synthetic biology, primarily due to the complexity of biological systems, and the lack of rigorous optimization methods that can cope with the combinatorial explosion as the number of biological parts increases. Current optimization methods for synthetic gene design rely on heuristic algorithms that are usually not deterministic, deliver sub-optimal solutions, and provide no guaranties on convergence or error bounds. Here, we introduce an optimization framework for the problem of part selection in synthetic gene circuits that is based on mixed integer non-linear programming (MINLP), which is a deterministic method that finds the globally optimal solution and guarantees convergence in finite time. Given a synthetic gene circuit, a library of characterized parts, and user-defined constraints, our method can find the optimal selection of parts that satisfy the constraints and best approximates the objective function given by the user. We evaluated the proposed method in the design of three synthetic circuits (a toggle switch, a transcriptional cascade, and a band detector), with both experimentally constructed and synthetic promoter libraries. Scalability and robustness analysis shows that the proposed framework scales well with the library size and the solution space. The work described here is a step towards a unifying, realistic framework for the automated design of biological circuits.

Enhancing Digital Fluency through a Training Program for Creative Problem Solving Using Computer Programming

ERIC Educational Resources Information Center

Kim, SugHee; Chung, KwangSik; Yu, HeonChang

2013-01-01

The purpose of this paper is to propose a training program for creative problem solving based on computer programming. The proposed program will encourage students to solve real-life problems through a creative thinking spiral related to cognitive skills with computer programming. With the goal of enhancing digital fluency through this proposed…

75 FR 43172 - Maternal, Infant, and Early Childhood Home Visiting Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-23

... the evaluation results have been published in a peer-reviewed journal; or (bb) quasi-experimental... design (i.e. randomized controlled trial [RCT] or quasi-experimental design [QED]), level of attrition... a quasi-experimental design as a study design in which sample members are selected for the program...

Access to Experimental Cancer Drugs

Cancer.gov

An experimental drug has been tested in the lab and with animals and approved for testing in people by the FDA, but can’t yet be advertised, sold, or prescribed. Experimental drugs may be available through clinical trials or expanded access programs - learn more about these programs and how to talk to your doctor.

Work Program. Fiscal Year 1972 for The Department of the Army. Research and Development in Training, Motivation, and Leadership

DTIC Science & Technology

1971-07-01

itself. IlumRRO assistance was requested by the Infantry School both for design of experimental tests and for analysis and interpretation of the data from...of Research. To develop an experimental Army literacy training program designed to provide a level of functional literacy appropriate to present...assigned under the provisions of a long- range program (up to two years in duration) designed by tlumRRO. Specially designed experimental

Prediction of sonic boom from experimental near-field overpressure data. Volume 1: Method and results

NASA Technical Reports Server (NTRS)

Glatt, C. R.; Hague, D. S.; Reiners, S. J.

1975-01-01

A computerized procedure for predicting sonic boom from experimental near-field overpressure data has been developed. The procedure extrapolates near-field pressure signatures for a specified flight condition to the ground by the Thomas method. Near-field pressure signatures are interpolated from a data base of experimental pressure signatures. The program is an independently operated ODIN (Optimal Design Integration) program which obtains flight path information from other ODIN programs or from input.

Experimental design for estimating unknown groundwater pumping using genetic algorithm and reduced order model

NASA Astrophysics Data System (ADS)

Ushijima, Timothy T.; Yeh, William W.-G.

2013-10-01

An optimal experimental design algorithm is developed to select locations for a network of observation wells that provide maximum information about unknown groundwater pumping in a confined, anisotropic aquifer. The design uses a maximal information criterion that chooses, among competing designs, the design that maximizes the sum of squared sensitivities while conforming to specified design constraints. The formulated optimization problem is non-convex and contains integer variables necessitating a combinatorial search. Given a realistic large-scale model, the size of the combinatorial search required can make the problem difficult, if not impossible, to solve using traditional mathematical programming techniques. Genetic algorithms (GAs) can be used to perform the global search; however, because a GA requires a large number of calls to a groundwater model, the formulated optimization problem still may be infeasible to solve. As a result, proper orthogonal decomposition (POD) is applied to the groundwater model to reduce its dimensionality. Then, the information matrix in the full model space can be searched without solving the full model. Results from a small-scale test case show identical optimal solutions among the GA, integer programming, and exhaustive search methods. This demonstrates the GA's ability to determine the optimal solution. In addition, the results show that a GA with POD model reduction is several orders of magnitude faster in finding the optimal solution than a GA using the full model. The proposed experimental design algorithm is applied to a realistic, two-dimensional, large-scale groundwater problem. The GA converged to a solution for this large-scale problem.

76 FR 25618 - Proposed Processed Raspberry Promotion, Research, and Information Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

...; FV-07-705-PR-2B] RIN 0581-AC79 Proposed Processed Raspberry Promotion, Research, and Information... industry-funded promotion, research, and information program for processed raspberries. The proposed program, Processed Raspberry Promotion, Research, and Information Order (Proposed Order), was submitted to...

[The effects of a diabetic educational program for coping with problem situation on self-efficacy, self care behaviors, coping and glycemic control in type 2 diabetic patients].

PubMed

Ko, Choun Hee; Gu, Mee Ock

2004-12-01

This study was conducted to develop and to test the effects of an educational program for coping with problem situations as a nursing intervention in the diabetic patient. A non-equivalent control group pretest-posttest design was used in this study. Data were collected from January to March, 2002. The subjects of the study consisted of 31 diabetic patients(experimental group: 17 patients, control group: 14 patients). The intervention of an educational program for coping with problem situations was applied to the experimental group for 4 weeks (total 8 hours). Data were collected before the educational program, immediately after and 1 months later and were analyzed with repeated measures ANOVA, t-test, and paired t-test. 1. There was a significant difference in self efficacy between the experimental and control groups (F=13.793, p=0.001). 2. There was a significant difference in self care behavior between the experimental and control groups (F=4.583, p=0.041). 3. There was a significant difference in coping behavior of the problem situation between the experimental and control groups (F=62.018, p=0.000). There was a significant difference according to experimental stages (F=4.546, p=0.015) and interaction between education and experimental stages (F=12.039, p=0.000). 4. There was a significant difference in glycemic control between the experimental and control groups (t=-3.112, p=0.004). These results support that a diabetic educational program for coping with problem situations is effective in promoting and maintaining self efficacy, self care behavior, problem coping behaviors and in improving glycemic control. Thus this program can be recommended as an effective nursing intervention of in-depth education for diabetic patient.

Assessment of analytical and experimental techniques utilized in conducting plume technology tests 575 and 593. [exhaust flow simulation (wind tunnel tests) of scale model Space Shuttle Orbiter

NASA Technical Reports Server (NTRS)

Baker, L. R.; Sulyma, P. R.; Tevepaugh, J. A.; Penny, M. M.

1976-01-01

Since exhaust plumes affect vehicle base environment (pressure and heat loads) and the orbiter vehicle aerodynamic control surface effectiveness, an intensive program involving detailed analytical and experimental investigations of the exhaust plume/vehicle interaction was undertaken as a pertinent part of the overall space shuttle development program. The program, called the Plume Technology program, has as its objective the determination of the criteria for simulating rocket engine (in particular, space shuttle propulsion system) plume-induced aerodynamic effects in a wind tunnel environment. The comprehensive experimental program was conducted using test facilities at NASA's Marshall Space Flight Center and Ames Research Center. A post-test examination of some of the experimental results obtained from NASA-MSFC's 14 x 14-inch trisonic wind tunnel is presented. A description is given of the test facility, simulant gas supply system, nozzle hardware, test procedure and test matrix. Analysis of exhaust plume flow fields and comparison of analytical and experimental exhaust plume data are presented.

43 CFR 404.51 - Are proposed projects under the Rural Water Supply Program reviewed by the Administration?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Water Supply Program reviewed by the Administration? 404.51 Section 404.51 Public Lands: Interior... SUPPLY PROGRAM Feasibility Studies § 404.51 Are proposed projects under the Rural Water Supply Program... the Reclamation's Rural Water Supply Program. This includes review under Executive Order 12322 to...

Advanced Simulation and Computing Fiscal Year 2016 Implementation Plan, Version 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCoy, M.; Archer, B.; Hendrickson, B.

2015-08-27

The Stockpile Stewardship Program (SSP) is an integrated technical program for maintaining the safety, surety, and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational capabilities to support these programs. The purpose of this IP is to outline key work requirements to be performed and to control individualmore » work activities within the scope of work. Contractors may not deviate from this plan without a revised WA or subsequent IP.« less

76 FR 63691 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by International...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... Short Term Options Series Program October 6, 2011. Pursuant to Section 19(b)(1) of the Securities... Proposed Rule Change The Exchange proposes to amend its rules to expand the Short Term Option Series... Term Option Series Program (``STOS Program'') \\3\\ so that the Exchange may select twenty-five option...

Directory of research projects: Planetary geology and geophysics program

NASA Technical Reports Server (NTRS)

Holt, Henry (Editor)

1992-01-01

Information about currently funded scientific research within the Planetary Geology and Geophysics Program is provided. The directory consists of the proposal summary sheet from each proposal funded under the program during Fiscal Year 1992. The sheets provide information about the research project, including title, principal investigator, institution, summary of research objectives, past accomplishments, and proposed new investigations.

78 FR 42138 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-15

... Effectiveness of Proposed Rule Change To Adopt a Priority Customer Rebate Program July 9, 2013. Pursuant to... of the Proposed Rule Change The Exchange is filing a proposal to adopt a Priority Customer Rebate... Priority Customer Rebate Program (the ``Program'') for the period beginning July 1, 2013 and ending...

75 FR 78284 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

... Effectiveness of Proposed Rule Change Relating to CBOE's Marketing Fee Program December 8, 2010. Pursuant to... its Marketing Fee Program. The text of the proposed rule change is available on the Exchange's Web... Rule Change 1. Purpose CBOE proposes to amend its Marketing Fee Program in two respects. First, CBOE...

76 FR 19169 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Effectiveness of Proposed Rule Change To Expand the $2.50 Strike Price Program March 31, 2011. Pursuant to... Exchange filed the proposal as a ``non- controversial'' proposed rule change pursuant to Section 19(b)(3)(A... to expand the Exchange's $2.50 Strike Price Program (the ``Program'') to permit the listing of...

Program to Promote Personal and Social Responsibility in the Secondary Classroom.

PubMed

Carbonero, Miguel A; Martín-Antón, Luis J; Otero, Lourdes; Monsalvo, Eugenio

2017-01-01

The performance of school children has been studied by considering partial relationships between several personal variables such as the link between cognition and motivation. However, contextual variables, such as a child's willingness to accept social responsibility, also influence students' social and academic performance. Thus, students with greater responsibility have a better attitude toward their studies, resulting in higher academic achievement. This 2-year study aims to reveal to what extent an intervention program affects student performance and is based on the Theory of Positive Action among young people proposed by Don Hellison and the Theory of Reasoned Action by Fishbein and Ajzen. The program focuses on positive influences on social and personal responsibility, taking into consideration parental styles, gender, and academic performance. The program was a part of the educational curricula in participating schools and it targeted four main areas: (a) teaching units using academic texts about social responsibility, (b) student training in mediation processes, (c) teacher training, and (d) family training and involvement. A total of 271 students took part from first and second year of Secondary Education (12-14 years old). The experimental group was made up of 132 students while the remaining 139 formed the control group. All participants completed the Assessment Scale of Social Responsibility Attitudes in Secondary Education and the Parent-Adolescent Communication Scale. Results show that students in the experimental group performed significantly better than those in the control group. Additionally, the issue of social responsibility seems to be related to commitment, self-discipline and perseverance. Regarding gender, males appear to score higher in the factor for well-mannered, friendly and tidy. Finally, a positive relationship has been identified between social responsibility attitudes and parenting with an open communicational style. This paper discusses the results so that schools can include programs aimed at improving social and personal responsibility.

Program to Promote Personal and Social Responsibility in the Secondary Classroom

PubMed Central

Carbonero, Miguel A.; Martín-Antón, Luis J.; Otero, Lourdes; Monsalvo, Eugenio

2017-01-01

The performance of school children has been studied by considering partial relationships between several personal variables such as the link between cognition and motivation. However, contextual variables, such as a child’s willingness to accept social responsibility, also influence students’ social and academic performance. Thus, students with greater responsibility have a better attitude toward their studies, resulting in higher academic achievement. This 2-year study aims to reveal to what extent an intervention program affects student performance and is based on the Theory of Positive Action among young people proposed by Don Hellison and the Theory of Reasoned Action by Fishbein and Ajzen. The program focuses on positive influences on social and personal responsibility, taking into consideration parental styles, gender, and academic performance. The program was a part of the educational curricula in participating schools and it targeted four main areas: (a) teaching units using academic texts about social responsibility, (b) student training in mediation processes, (c) teacher training, and (d) family training and involvement. A total of 271 students took part from first and second year of Secondary Education (12–14 years old). The experimental group was made up of 132 students while the remaining 139 formed the control group. All participants completed the Assessment Scale of Social Responsibility Attitudes in Secondary Education and the Parent–Adolescent Communication Scale. Results show that students in the experimental group performed significantly better than those in the control group. Additionally, the issue of social responsibility seems to be related to commitment, self-discipline and perseverance. Regarding gender, males appear to score higher in the factor for well-mannered, friendly and tidy. Finally, a positive relationship has been identified between social responsibility attitudes and parenting with an open communicational style. This paper discusses the results so that schools can include programs aimed at improving social and personal responsibility. PMID:28588529

Facilitating Classroom Innovation in the Geosciences Through the NSF Transforming Undergraduate Education in Science, Technology, Engineering, and Mathematics (TUES) Program

NASA Astrophysics Data System (ADS)

Singer, J.; Ryan, J. G.

2012-12-01

The Transforming Undergraduate Education in Science, Technology, Engineering, and Mathematics (TUES) program seeks to improve the quality of science, technology, engineering, and mathematics (STEM) education for all undergraduate students. Activities supported by the TUES program include the creation, adaptation, and dissemination of learning materials and teaching strategies, development of faculty expertise, implementation of educational innovations, and research on STEM teaching and learning. The TUES program especially encourages projects that have the potential to transform undergraduate STEM education and active dissemination and building a community of users are critical components of TUES projects. To raise awareness about the TUES program and increase both the quality and quantity of proposals submitted by geoscientists to the program, information sessions and proposal writing retreats are being conducted. Digital resources developed especially for the geosciences community are available at www.buffalostate.edu/RTUGeoEd to share information about the TUES program and the many ways this NSF program supports innovation in geoscience education. This presentation also addresses identified impediments to submitting a TUES proposal and strategies for overcoming reasons discouraging geoscientists from preparing a proposal and/or resubmitting a declined proposal.

77 FR 65037 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Order Approving a Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... Organizations; C2 Options Exchange, Incorporated; Order Approving a Proposed Rule Change To Adopt a Designated... thereunder,\\2\\ a proposed rule change to adopt a Designated Primary Market-Maker (``DPM'') program. The... the Notice, C2 has proposed to adopt a DPM program. The associated proposed rules are based on the...

Teacher's Guide to SERAPHIM Software I. Chemistry: Experimental Foundations.

ERIC Educational Resources Information Center

Bogner, Donna J.

Designed to assist chemistry teachers in selecting appropriate software programs, this publication is the first in a series of six teacher's guides from Project SERAPHIM, a program sponsored by the National Science Foundation. This guide is keyed to the chapters of the text "Chemistry: Experimental Foundations." Program suggestions are…

34 CFR 387.10 - What types of projects are authorized under this program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true What types of projects are authorized under this program...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND....10 What types of projects are authorized under this program? The Experimental and Innovative Training...

34 CFR 387.10 - What types of projects are authorized under this program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 2 2014-07-01 2013-07-01 true What types of projects are authorized under this program...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EXPERIMENTAL AND....10 What types of projects are authorized under this program? The Experimental and Innovative Training...

Directed reflectivity, long life AMTEC condenser (DRC). Final report of Phase II SBIR program[Alkali Metal ThermoElectric Converter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, Thomas K.

The Alkali Metal Thermal to Electric Converter (AMTEC) is a static energy conversion device that operates at high thermal to electric conversion efficiencies that are essentially independent of size, have reached 19% and are expected to reach 25% to 30% in 1997. AMTEC systems have been chosen by NASA and DOE for spacecraft applications and have considerable promise for a wide variety of terrestrial applications. Reduction of parasitic heat losses in AMTEC systems related to radiative heat transfer from the hot side to the condenser can make a substantial contribution to system efficiency. Through design, analysis and the fabrication andmore » testing of cells and systems, the proposed program to develop a Directed Reflectivity Condenser (DRC) has investigated the feasibility of an improved AMTEC condenser component. Phase 1 work showed the potential for adding from 4% to 7% to overall system efficiency for identical operating conditions using the concept. A detailed thermal analysis of several DRC capped cell designs was carried out and some of the conditions under which a DRC, used as the condenser at an end cap of a cylindrical converter, can reduce thermal radiation related losses were determined. A model experimental converter was built and tested to compare DRC and planar condenser surfaces. The results of both analysis and experiment indicate that for moderate aspect ratios of a cylindrical, end condensed converter, the DRC can reduce overall thermal losses by up to 4%. The initial effort in Phase 2 extended the analysis to a novel 150 watt radial AMTEC cell design. This analysis indicated that for the effective aspect ratio of this new converter design, the system performance at the 100+ watt level was not significantly improved by use of a DRC type condenser surface. Further analyses however showed that for cylindrical, end-condensed converters, optimized for use with internal radiation shields, the use of DRC surfaces on the side walls of the converter could be more effective than on the condenser end surface itself. The experimental work in Phase 2 was intended to incorporate a DRC into this cell design and use its measured performance to refine the state-of-the-art AMTEC analytical models. Because the analysis had indicated that the new radial converter design, which may be useful for systems at the {approx} 100 watt level was not much assisted by the DRC properties, this program was redirected toward the simpler cylindrical converter design with the corner cube surfaces on the side walls. The Phase II program was proposed and planned with a funding level substantially below the maximum potentially available for Phase II programs at that time. At the time, there were two other funded government sponsored programs at AMPS for which positive results of the analyses described in this report were expected to lead to incorporation of the DRC concept into converters scheduled to be built for these programs. The programs of interest were the Air Force program titled ''Radiation Tolerant, Eclipse Compatible, Solar AMTEC System'' (F29601-99-C-0132) and the DOE/NASA Advanced Radioisotope Power System (ARPS) program. Shortly after its start, the Air Force program was canceled due to elimination of AF SBIR funds at AFRL and the ARPS program was reduced to a level that could not support introduction of novel concept testing. As a result of these two circumstances, the direct testing of the DRC concept in a full up converter was not completed in the Phase II period.« less

7 CFR 3403.6 - Content of proposals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... previously completed research, will not be accepted. Literature surveys should be conducted prior to... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Preparation of Proposals § 3403.6 Content of proposals. (a) The proposed research must be responsive to one of the USDA program interests stated in the...

7 CFR 3403.6 - Content of proposals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... previously completed research, will not be accepted. Literature surveys should be conducted prior to... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Preparation of Proposals § 3403.6 Content of proposals. (a) The proposed research must be responsive to one of the USDA program interests stated in the...

7 CFR 3403.6 - Content of proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... previously completed research, will not be accepted. Literature surveys should be conducted prior to... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Preparation of Proposals § 3403.6 Content of proposals. (a) The proposed research must be responsive to one of the USDA program interests stated in the...

7 CFR 3403.6 - Content of proposals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... previously completed research, will not be accepted. Literature surveys should be conducted prior to... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Preparation of Proposals § 3403.6 Content of proposals. (a) The proposed research must be responsive to one of the USDA program interests stated in the...

77 FR 6776 - Agency Information Collection Activities: Proposed Collection; Comment Request-National School...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

...: Proposed Collection; Comment Request--National School Lunch Program and School Breakfast Program Access... be directed to Steven Carlson at 703-305-2017. SUPPLEMENTARY INFORMATION: Title: National School Lunch Program and School Breakfast Program Access, Participation, Eligibility, and Certification Study...

Low-temperature sensitivity periodically tapered photonic crystal-fiber-based refractometer.

PubMed

Wang, Pengfei; Bo, Lin; Guan, Chunying; Semenova, Yuliya; Wu, Qiang; Brambilla, Gilberto; Farrell, Gerald

2013-10-01

In this Letter, an all-fiber refractometer with a simple configuration of periodical tapers on a photonic crystal fiber (PCF) is proposed and investigated experimentally. The proposed fiber refractive index (RI) sensor consists of a PCF sandwiched between two standard single-mode fibers, with tapers periodically fabricated along the PCF using a CO(2) laser beam focused by a ZnSe cylindrical lens. The proposed fiber sensor can be used for RI sensing by measuring the wavelength shift of the multimode interference dip over the transmission spectrum. An average sensitivity of 222 nm/RIU has been experimentally achieved over a RI range from 1.33 to 1.38. The proposed refractometer is also significantly less sensitive to temperature, and an experimental demonstration of this reduced sensitivity is presented. The proposed RI sensor benefits from simplicity and low-cost and achieves a competitive sensitivity compared with other existing fiber-optic sensors.

Inflation Fossils in Cosmic Structure

NASA Astrophysics Data System (ADS)

Kamionkowski, Marc

The agreement of the predictions of inflation with increasingly precise cosmic microwave background (CMB) and large-scale-structure (LSS) data is remarkable. The notion that such a simple early-Universe scenario, based on still-mysterious ultra-high-energy physics, can explain such a wealth of precise data is simply amazing. An active ongoing program of research is afoot to seek the CMB polarization signatures of inflationary gravitational waves and measure the primordial bispectrum in order to learn about inflation. Still, there is far more that can be done to probe inflationary physics, and no stone should be left unturned in this quest. Here we propose a multi-component program of theoretical research that includes model building, new CMB/LSS tests, a potentially powerful new survey strategy, and the investigation of a new observational avenue for large-scale structure. We propose to broaden the circle of ideas to empirically probe inflation. To begin, the hemispherical power asymmetry seen in WMAP and Planck is truly striking. While it may simply be an unusual statistical fluke, a more tantalizing possibility is that it is a remnant of the pre-inflationary Universe. We propose to develop and study several physical models for this asymmetry and work out other testable predictions of these models. Only by pursuing other signatures of whatever new physics may be responsible for this asymmetry will we be able to infer if it is truly a window to new physics. We also plan to develop departures from statistical isotropy (SI) as a test of inflationary models. We have recently shown that single-field slow-roll inflation generically predicts a quadrupolar departure from SI in primordial perturbations, albeit a very small one. The power quadrupole is expected, however, to be significantly larger in more general inflationary models. We propose to calculate these power quadrupoles so that new constraints to the power quadrupole from CMB and LSS data can be applied to test these models. In a somewhat different vein, we propose to study adaptive strategies for cosmological measurements. Considerable resources are being invested in the ongoing search for B modes in the CMB polarization. This search can be performed on a small patch of sky, but it is optimized by finding the patch of sky that is cleanest of foregrounds. We propose to develop adaptive survey strategies, using lessons learned from the analogous multi-armed bandit problem in probability theory, to optimize B mode searches. Preliminary estimates suggest that such a strategy can improve the sensitivity to primordial gravitational waves by factors of at least 2--3, and possibly much more. We then plan to study the possibility to apply similar strategies to the search for 21-cm fluctuations from the epoch of reionization (EoR) and also to identify an optimal field for a possible JWST deep field survey. Finally, CO intensity mapping has recently been identified as a new and promising probe of the EoR. However, CO intensity mapping may also be used to study large-scale structure at intermediate redshifts (z~1-6) that are important for inflation, dark-energy, and galaxy formation. We propose to calculate angular power spectra of the CO intensity at these redshifts and estimate sensitivities to signals and forecast parameter estimation for various experimental configurations. This work will be essential to guide the development of experiments to seek this signal. In summary, the proposed research will open new avenues to probe the beginning of time with the CMB and LSS, optimize several ongoing measurements, and lay the theoretical groundwork to open a new experimental avenue toward LSS. The proposed research is well aligned with the goals of NASA's Physics of the Cosmos Program. It will provide theoretical support to several current and in-the-pipeline NASA missions and help guide the development of new missions.

Learning Effects of an Experimental EFL Program in Second Life

ERIC Educational Resources Information Center

Wang, Charles Xiaoxue; Calandra, Brendan; Hibbard, Susan T.; McDowell Lefaiver, Mary L.

2012-01-01

This paper reports on the effects an experimental English as a Foreign Language (EFL) program in Second Life (SL) had on Chinese student EFL learning. The study took an evaluative approach using quasi-experimental design with participants from one Chinese university and one American university in the southeastern United States. Results indicated…

20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

Code of Federal Regulations, 2011 CFR

2011-04-01

... you are placed in a control group which is not subject to the alternative requirements, limitations... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Experimental, pilot, and demonstration... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program...

20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

Code of Federal Regulations, 2013 CFR

2013-04-01

... you are placed in a control group which is not subject to the alternative requirements, limitations... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Experimental, pilot, and demonstration... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program...

20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

Code of Federal Regulations, 2014 CFR

2014-04-01

... you are placed in a control group which is not subject to the alternative requirements, limitations... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Experimental, pilot, and demonstration... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program...

20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

Code of Federal Regulations, 2012 CFR

2012-04-01

... you are placed in a control group which is not subject to the alternative requirements, limitations... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Experimental, pilot, and demonstration... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program...

20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... you are placed in a control group which is not subject to the alternative requirements, limitations... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Experimental, pilot, and demonstration... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program...

Understanding Complexity and Self-Organization in a Defense Program Management Organization (Experimental Design)

DTIC Science & Technology

2016-03-18

SPONSORED REPORT SERIES Understanding Complexity and Self - Organization in a Defense Program Management Organization (Experimental Design...experiment will examine the decision-making process within the program office and the self - organization of key program office personnel based upon formal...and informal communications links. Additionally, we are interested in the effects of this self - organizing process on the organization’s shared

Mesoscale Design of Magnetoelectric Nanocomposites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Viehland, Dwight; Priya, Shashank

This is a final report for a transient program that was issued to Virginia Tech as a new program (DE-SC0001450), rather than as a renewal to our existing program (DE-FG02-06ER46290). The renewal proposal was submitted in November 2014, but because of confusion in the negotiations got issued as a new program. Subsequently, a correction was made where the new program (DE-SC0001450) was terminated, and a renewal to the existing program (DE-FG02-06ER46290) issued. About $8,000 was expended on the new program before the mistake was discovered, and actions begun to correct it. The Department of Materials Science and Engineering at Virginiamore » Tech issued a ‘Letter of Guarantee’ to the University to continue work while the issues were sorted out. The renewal proposal (DE-FG02-06ER46290) that was eventually funded was the same one as the new proposal (DE-SC0001450) that was initially funded. The $8,000 expended on the new proposal was subtracted from the eventual amount given in the renewal proposal. Here, we submit the final report for this new program (DE-SC0001450) that was terminated. Since the Statement of Work was identical to the renewal proposal (DE-FG02-06ER46290), we submit to you as the final report for the new program (DE-SC0001450) the same information that we submitted as our annual report for DE-FG02-06ER46290 that was submitted to the program manager (Refik Kortan) in June 2016.« less

75 FR 76749 - Notice of Submission of Proposed Information Collection to OMB; Emergency Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-09

... Experiments Grant Program; Notice of Proposed Information Collection for Public Comment AGENCY: Office of the... Notice ALSO LISTS the Following Information Title of Proposal: Natural Experiments Grant Program...

Composition of web services using Markov decision processes and dynamic programming.

PubMed

Uc-Cetina, Víctor; Moo-Mena, Francisco; Hernandez-Ucan, Rafael

2015-01-01

We propose a Markov decision process model for solving the Web service composition (WSC) problem. Iterative policy evaluation, value iteration, and policy iteration algorithms are used to experimentally validate our approach, with artificial and real data. The experimental results show the reliability of the model and the methods employed, with policy iteration being the best one in terms of the minimum number of iterations needed to estimate an optimal policy, with the highest Quality of Service attributes. Our experimental work shows how the solution of a WSC problem involving a set of 100,000 individual Web services and where a valid composition requiring the selection of 1,000 services from the available set can be computed in the worst case in less than 200 seconds, using an Intel Core i5 computer with 6 GB RAM. Moreover, a real WSC problem involving only 7 individual Web services requires less than 0.08 seconds, using the same computational power. Finally, a comparison with two popular reinforcement learning algorithms, sarsa and Q-learning, shows that these algorithms require one or two orders of magnitude and more time than policy iteration, iterative policy evaluation, and value iteration to handle WSC problems of the same complexity.

77 FR 24508 - Notice of Submission of Proposed Information Collection to OMB Community Development Block Grant...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... Proposed Information Collection to OMB Community Development Block Grant (CDBG) Entitlement Program AGENCY... subject proposal. The closeout instructions apply to Community Development Block Grant (CDBG) programs... responses. This notice also lists the following information: Title of Proposal: Community Development Block...

75 FR 68529 - Proposed Christmas Tree Promotion, Research, and Information Order; Referendum Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

...-0008-PR] RIN 0581-AD00 Proposed Christmas Tree Promotion, Research, and Information Order; Referendum...) is favored by domestic producers and importers of Christmas trees. This proposed program would be... received a proposal for a national research and promotion program for Christmas trees from the Christmas...

76 FR 67470 - Notice of Submission of Proposed Information Collection to OMB; Energy Innovation Fund...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-01

... Proposed Information Collection to OMB; Energy Innovation Fund--Multifamily Energy Pilot Program AGENCY... proposals for increasing the energy efficiency of Multifamily Housing. DATES: Comments Due Date: December 1... following information: Title of Proposal: Energy Innovation Fund--Multifamily Energy Pilot Program. OMB...

7 CFR 3405.7 - Joint project proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Joint project proposals. 3405.7 Section 3405.7... AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.7 Joint project proposals. Applicants are encouraged to submit joint project proposals as defined in § 3405.2(m), which address regional...

76 FR 24041 - Notice of Proposed Information Collection: Comment Request; HUD Housing Counseling Program-Agency...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... Information Collection: Comment Request; HUD Housing Counseling Program--Agency Performance Review AGENCY.... This Notice also lists the following information: Title of Proposal: HUD Housing Counseling Program... the Department's Housing Counseling Program, authorized by Section 106 of the Housing and Urban...

76 FR 5187 - Notice of Proposed Information Collection: Comment Request; Emergency Homeowners' Loan Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... Information Collection: Comment Request; Emergency Homeowners' Loan Program Data Elements AGENCY: Office of... following information: Title of Proposal: Emergency Homeowners' Loan Program Data Elements. Description of... of Affected Public: Emergency Homeowners' Loan Program Data Elements. Estimation of the total numbers...

On the search for the electric dipole moment of strange and charm baryons at LHC

NASA Astrophysics Data System (ADS)

Botella, F. J.; Garcia Martin, L. M.; Marangotto, D.; Martinez Vidal, F.; Merli, A.; Neri, N.; Oyanguren, A.; Ruiz Vidal, J.

2017-03-01

Permanent electric dipole moments (EDMs) of fundamental particles provide powerful probes for physics beyond the Standard Model. We propose to search for the EDM of strange and charm baryons at LHC, extending the ongoing experimental program on the neutron, muon, atoms, molecules and light nuclei. The EDM of strange Λ baryons, selected from weak decays of charm baryons produced in p p collisions at LHC, can be determined by studying the spin precession in the magnetic field of the detector tracking system. A test of CPT symmetry can be performed by measuring the magnetic dipole moment of Λ and \\overline{Λ} baryons. For short-lived {Λ} ^+c and {Ξ} ^+c baryons, to be produced in a fixed-target experiment using the 7 TeV LHC beam and channeled in a bent crystal, the spin precession is induced by the intense electromagnetic field between crystal atomic planes. The experimental layout based on the LHCb detector and the expected sensitivities in the coming years are discussed.

High Frequency Plasma Generators for Ion Thrusters

NASA Technical Reports Server (NTRS)

Divergilio, W. F.; Goede, H.; Fosnight, V. V.

1981-01-01

The results of a one year program to experimentally adapt two new types of high frequency plasma generators to Argon ion thrusters and to analytically study a third high frequency source concept are presented. Conventional 30 cm two grid ion extraction was utilized or proposed for all three sources. The two plasma generating methods selected for experimental study were a radio frequency induction (RFI) source, operating at about 1 MHz, and an electron cyclotron heated (ECH) plasma source operating at about 5 GHz. Both sources utilize multi-linecusp permanent magnet configurations for plasma confinement. The plasma characteristics, plasma loading of the rf antenna, and the rf frequency dependence of source efficiency and antenna circuit efficiency are described for the RFI Multi-cusp source. In a series of tests of this source at Lewis Research Center, minimum discharge losses of 220+/-10 eV/ion were obtained with propellant utilization of .45 at a beam current of 3 amperes. Possible improvement modifications are discussed.

Stray light rejection in giant externally-occulted solar coronagraphs: experimental developments

NASA Astrophysics Data System (ADS)

Venet, M.; Bazin, C.; Koutchmy, S.; Lamy, P.

2017-11-01

The advent of giant, formation-flight, externally-occulted solar coronagraphs such as ASPIICS (Association de Satellites Pour l'Imagerie et l'Interférométrie de la Couronne Solaire [1,2,3,4]) selected by the European Space Agency (ESA) for its third PROBA (Project for On-Board Autonomy) mission of formation flying demonstration (presently in phase B) and Hi-RISE proposed in the framework of ESA Cosmic Vision program, presents formidable challenges for the study and calibration of instrumental stray light. With distances between the external occulter (EO) and the optical pupil (OP) exceeding hundred meters and occulter sizes larger than a meter, it becomes impossible to perform tests at the real scale. The requirement to limit the over-occultation to less than 1.05 Rsun, orders of magnitude to what has been achieved so far in past coronagraphs, further adds to the challenge. We are approaching the problem experimentally using reduced scale simulators and present below a progress report of our work.

Getting There from Here: Research on the Effects of Work-Family Initiatives on Work-Family Conflict and Business Outcomes.

PubMed

Kelly, Erin L; Kossek, Ellen Ernst; Hammer, Leslie B; Durham, Mary; Bray, Jeremy; Chermack, Kelly; Murphy, Lauren A; Kaskubar, Dan

2008-08-01

Many employing organizations have adopted work-family policies, programs, and benefits. Yet managers in employing organizations simply do not know what organizational initiatives actually reduce work-family conflict and how these changes are likely to impact employees and the organization. We examine scholarship that addresses two broad questions: first, do work-family initiatives reduce employees' work-family conflict and/or improve work-family enrichment? Second, does reduced work-family conflict improve employees' work outcomes and, especially, business outcomes at the organizational level? We review over 150 peer-reviewed studies from a number of disciplines in order to summarize this rich literature and identify promising avenues for research and conceptualization. We propose a research agenda based on four primary conclusions: the need for more multi-level research, the necessity of an interdisciplinary approach, the benefits of longitudinal studies that employ quasi-experimental or experimental designs and the challenges of translating research into practice in effective ways.

Preliminary Tritium Management Design Activities at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrison, Thomas J.; Felde, David K.; Logsdon, Randall J.

2016-09-01

Interest in salt-cooled and salt-fueled reactors has increased over the last decade (Forsberg et al. 2016). Several private companies and universities in the United States, as well as governments in other countries, are developing salt reactor designs and/or technology. Two primary issues for the development and deployment of many salt reactor concepts are (1) the prevention of tritium generation and (2) the management of tritium to prevent release to the environment. In 2016, the US Department of Energy (DOE) initiated a research project under the Advanced Reactor Technology Program to (1) experimentally assess the feasibility of proposed methods for tritiummore » mitigation and (2) to perform an engineering demonstration of the most promising methods. This document describes results from the first year’s efforts to define, design, and build an experimental apparatus to test potential methods for tritium management. These efforts are focused on producing a final design document as the basis for the apparatus and its scheduled completion consistent with available budget and approvals for facility use.« less

Getting There from Here: Research on the Effects of Work–Family Initiatives on Work–Family Conflict and Business Outcomes

PubMed Central

KELLY, ERIN L.; KOSSEK, ELLEN ERNST; HAMMER, LESLIE B.; DURHAM, MARY; BRAY, JEREMY; CHERMACK, KELLY; MURPHY, LAUREN A.; KASKUBAR, DAN

2009-01-01

Many employing organizations have adopted work–family policies, programs, and benefits. Yet managers in employing organizations simply do not know what organizational initiatives actually reduce work–family conflict and how these changes are likely to impact employees and the organization. We examine scholarship that addresses two broad questions: first, do work–family initiatives reduce employees’ work–family conflict and/or improve work–family enrichment? Second, does reduced work–family conflict improve employees’ work outcomes and, especially, business outcomes at the organizational level? We review over 150 peer-reviewed studies from a number of disciplines in order to summarize this rich literature and identify promising avenues for research and conceptualization. We propose a research agenda based on four primary conclusions: the need for more multi-level research, the necessity of an interdisciplinary approach, the benefits of longitudinal studies that employ quasi-experimental or experimental designs and the challenges of translating research into practice in effective ways. PMID:20589229

76 FR 18570 - Notice of Proposed Information Collection for Public Comment; HOPE VI Public Housing Programs...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... Information Collection for Public Comment; HOPE VI Public Housing Programs: Funding and Program Data... responses. This Notice also lists the following information: Title of Proposal: HOPE VI program. OMB Control... (Pub. L. 105- 276, 112 Stat. 2461, approved October 21, 1998) and revised by the HOPE VI Program...

76 FR 12926 - Clean Air Act Proposed Interim Approval of Title V Operating Permits Program; Southern Ute Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... Proposed Interim Approval of Title V Operating Permits Program; Southern Ute Indian Tribe AGENCY... Title V Operating Permits Program submitted by the Southern Ute Indian Tribe (Tribe). The Tribe's Title V Operating Permit Program (Title V Program) was submitted for the purpose of administering a tribal...

77 FR 40120 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... Effectiveness of a Proposed Rule Change Relating to the Penny Pilot Program June 29, 2012. Pursuant to Section... relating to the Penny Pilot Program. The text of the proposed rule change is available on the Exchange's... The Penny Pilot Program is scheduled to expire on June 30, 2012. CBOE proposes to extend the Pilot...

76 FR 48935 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... the $1 Strike Price Interval Program August 4, 2011. Pursuant to Section 19(b)(1) of the Securities... Proposed Rule Change CBOE proposes to amend its rules in order to simplify the $1 Strike Price Interval... Policy .01 to Rule 5.5 in order to simplify the $1 Strike Price Interval Program (``Program''). In 2003...

An improved swarm optimization for parameter estimation and biological model selection.

PubMed

Abdullah, Afnizanfaizal; Deris, Safaai; Mohamad, Mohd Saberi; Anwar, Sohail

2013-01-01

One of the key aspects of computational systems biology is the investigation on the dynamic biological processes within cells. Computational models are often required to elucidate the mechanisms and principles driving the processes because of the nonlinearity and complexity. The models usually incorporate a set of parameters that signify the physical properties of the actual biological systems. In most cases, these parameters are estimated by fitting the model outputs with the corresponding experimental data. However, this is a challenging task because the available experimental data are frequently noisy and incomplete. In this paper, a new hybrid optimization method is proposed to estimate these parameters from the noisy and incomplete experimental data. The proposed method, called Swarm-based Chemical Reaction Optimization, integrates the evolutionary searching strategy employed by the Chemical Reaction Optimization, into the neighbouring searching strategy of the Firefly Algorithm method. The effectiveness of the method was evaluated using a simulated nonlinear model and two biological models: synthetic transcriptional oscillators, and extracellular protease production models. The results showed that the accuracy and computational speed of the proposed method were better than the existing Differential Evolution, Firefly Algorithm and Chemical Reaction Optimization methods. The reliability of the estimated parameters was statistically validated, which suggests that the model outputs produced by these parameters were valid even when noisy and incomplete experimental data were used. Additionally, Akaike Information Criterion was employed to evaluate the model selection, which highlighted the capability of the proposed method in choosing a plausible model based on the experimental data. In conclusion, this paper presents the effectiveness of the proposed method for parameter estimation and model selection problems using noisy and incomplete experimental data. This study is hoped to provide a new insight in developing more accurate and reliable biological models based on limited and low quality experimental data.