Identifiability, genomics and U.K. data protection law.

PubMed

Curren, Liam; Boddington, Paula; Gowans, Heather; Hawkins, Naomi; Kanellopoulou, Nadja; Kaye, Jane; Melham, Karen

2010-09-01

Analyses of individuals' genomes--their entire DNA sequence--have increased knowledge about the links between genetics and disease. Anticipated advances in 'next generation' DNA-sequencing techniques will see the routine research use of whole genomes, rather than distinct parts, within the next few years. The scientific benefits of genomic research are, however, accompanied by legal and ethical concerns. Despite the assumption that genetic research data can and will be rendered anonymous, participants' identities can sometimes be elucidated, which could cause data protection legislation to apply. We undertake a timely reappraisal of these laws--particularly new penalties--and identifiability in genomic research.

75 FR 60456 - Board of Scientific Counselors, Executive Committee Meeting-October 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... Research Program Performance Evaluation session; an ORD update; and future business. The meeting is open to... Protection Agency, Office of Research and Development (ORD), gives notice of a meeting of the Board of.... All times noted are eastern time. The meeting may adjourn early if all business is finished. Requests...

Resilience in young children involved with child protective services.

PubMed

Sattler, Kierra M P; Font, Sarah A

2018-01-01

Child maltreatment increases the risk of poor developmental outcomes. However, some children display resilience, meaning they are high-functioning despite their adverse experiences. To date, few research studies have examined protective factors among very young maltreated children. Yet, domains of resilience, and the protective factors that promote resilience among maltreated children, are likely to differ by developmental stage. Drawing on ecological systems theory and life course theory, we examined how protective factors at multiple ecological levels across early childhood were related to social and cognitive resilience among very young children involved with child protective services. The results demonstrated that the buffering effects of protective factors varied by social or cognitive resilience and the cumulative effects of protective factors were more consistently related to later resilience than protective factors at specific time points. In addition, the influence of specific protective factors on resilience slightly varied by initial in-home or out-of-home placement. These findings have important policy and research implications for promoting optimal development among children involved in child protective services. Copyright © 2017 Elsevier Ltd. All rights reserved.

Integration of Planetary Protection Activities

NASA Technical Reports Server (NTRS)

Race, Margaret S.

2000-01-01

Research and activities under this grant have focused on a systematic examination and analysis of critical questions likely to impact planetary protection (PP) controls and implementation for Mars sample return missions (MSR). Four areas in the non-scientific and social realms were selected for special attention because of their importance to future mission planning and concern about critical timing or possible economic impacts on MSR mission implementation. These include: (1) questions of legal uncertainty and the decision making process, (2) public perception of risks associated with sample return, (3) risk communication and Education/Public Outreach , and (4) planetary protection implications of alternative mission architectures, for both robotic and human sample return missions. In its entirety, NAG 2-986 has encompassed three categories of activity: (1) research and analysis (Race), (2) subcontracted research (MacGregor/Decision Research), and (3) consulting services.

Human research ethics committees: examining their roles and practices.

PubMed

Guillemin, Marilys; Gillam, Lynn; Rosenthal, Doreen; Bolitho, Annie

2012-07-01

Considerable time and resources are invested in the ethics review process. We present qualitative data on how human research ethics committee members and health researchers perceive the role and function of the committee. The findings are based on interviews with 34 Australian ethics committee members and 54 health researchers. Although all participants agreed that the primary role of the ethics committee was to protect participants, there was disagreement regarding the additional roles undertaken by committees. Of particular concern were the perceptions from some ethics committee members and researchers that ethics committees were working to protect the institution's interests, as well as being overprotective toward research participants. This has the potential to lead to poor relations and mistrust between ethics committees and researchers.

Regenerative Medicine Will Make Orthopaedic Implants Obsolete In Our Time Orthopaedic Research Society First Annual Meeting Debate, San Diego, March 21st , 2017.

PubMed

Johnstone, Brian; Jacobs, Joshua J; Sandell, Linda J; Wilkinson, J Mark

2018-05-10

The mission of the Orthopaedic Research Society is to promote and advance musculoskeletal research worldwide. With this in mind, the Annual Meeting Program Committee sought to establish a debate as a key component of the meeting. Our purpose was to provoke discussion on topics that are core to our mission and to engage all constituencies within the society by examining questions of broad relevance. To this end, the topic "Regenerative medicine will make orthopaedic implants obsolete in our time" was selected as the title of the inaugural debate. The arguments for and against the motion are presented in this perspectives article. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Determination of protection zones for Dutch groundwater wells against virus contamination--uncertainty and sensitivity analysis.

PubMed

Schijven, J F; Mülschlegel, J H C; Hassanizadeh, S M; Teunis, P F M; de Roda Husman, A M

2006-09-01

Protection zones of shallow unconfined aquifers in The Netherlands were calculated that allow protection against virus contamination to the level that the infection risk of 10(-4) per person per year is not exceeded with a 95% certainty. An uncertainty and a sensitivity analysis of the calculated protection zones were included. It was concluded that protection zones of 1 to 2 years travel time (206-418 m) are needed (6 to 12 times the currently applied travel time of 60 days). This will lead to enlargement of protection zones, encompassing 110 unconfined groundwater well systems that produce 3 x 10(8) m3 y(-1) of drinking water (38% of total Dutch production from groundwater). A smaller protection zone is possible if it can be shown that an aquifer has properties that lead to greater reduction of virus contamination, like more attachment. Deeper aquifers beneath aquitards of at least 2 years of vertical travel time are adequately protected because vertical flow in the aquitards is only 0.7 m per year. The most sensitive parameters are virus attachment and inactivation. The next most sensitive parameters are grain size of the sand, abstraction rate of groundwater, virus concentrations in raw sewage and consumption of unboiled drinking water. Research is recommended on additional protection by attachment and under unsaturated conditions.

40 CFR 26.1601 - EPA review of proposed human research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false EPA review of proposed human research... OF HUMAN SUBJECTS Review of Proposed and Completed Human Research § 26.1601 EPA review of proposed human research. (a) EPA shall review all protocols submitted under § 26.1125 in a timely manner. With...

40 CFR 26.1601 - EPA review of proposed human research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false EPA review of proposed human research... OF HUMAN SUBJECTS Review of Proposed and Completed Human Research § 26.1601 EPA review of proposed human research. (a) EPA shall review all protocols submitted under § 26.1125 in a timely manner. With...

40 CFR 26.1601 - EPA review of proposed human research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false EPA review of proposed human research... OF HUMAN SUBJECTS Review of Proposed and Completed Human Research § 26.1601 EPA review of proposed human research. (a) EPA shall review all protocols submitted under § 26.1125 in a timely manner. With...

A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol.

PubMed

Hawkes, Anna L; Hamilton, Kyra; White, Katherine M; McD Young, Ross

2012-01-03

Most skin cancers are preventable by encouraging consistent use of sun protective behaviour. In Australia, adolescents have high levels of knowledge and awareness of the risks of skin cancer but exhibit significantly lower sun protection behaviours than adults. There is limited research aimed at understanding why people do or do not engage in sun protective behaviour, and an associated absence of theory-based interventions to improve sun safe behaviour. This paper presents the study protocol for a school-based intervention which aims to improve the sun safe behaviour of adolescents. Approximately 400 adolescents (aged 12-17 years) will be recruited through Queensland, Australia public and private schools and randomized to the intervention (n = 200) or 'wait-list' control group (n = 200). The intervention focuses on encouraging supportive sun protective attitudes and beliefs, fostering perceptions of normative support for sun protection behaviour, and increasing perceptions of control/self-efficacy over using sun protection. It will be delivered during three × one hour sessions over a three week period from a trained facilitator during class time. Data will be collected one week pre-intervention (Time 1), and at one week (Time 2) and four weeks (Time 3) post-intervention. Primary outcomes are intentions to sun protect and sun protection behaviour. Secondary outcomes include attitudes toward performing sun protective behaviours (i.e., attitudes), perceptions of normative support to sun protect (i.e., subjective norms, group norms, and image norms), and perceived control over performing sun protective behaviours (i.e., perceived behavioural control). The study will provide valuable information about the effectiveness of the intervention in improving the sun protective behaviour of adolescents. © 2011 Hawkes et al; licensee BioMed Central Ltd.

Deregulating Low-Risk Research

ERIC Educational Resources Information Center

Shamoo, Adil E.

2007-01-01

In the past few decades, with the explosion of biotechnology and the aging of the population, the use of human subjects in research has increased significantly. The United States has done much to protect human research subjects, and no one can deny the importance of keeping them safe. But at the same time, researchers whose work poses no threat to…

Developing Global Leaders for Research, Regulation, and Stewardship of Crop Protection Chemistry in the 21st Century.

PubMed

Unsworth, John B; Corsi, Camilla; Van Emon, Jeanette M; Farenhorst, Annemieke; Hamilton, Denis J; Howard, Cody J; Hunter, Robert; Jenkins, Jeffrey J; Kleter, Gijs A; Kookana, Rai S; Lalah, Joseph O; Leggett, Michael; Miglioranza, Karina S B; Miyagawa, Hisashi; Peranginangin, Natalia; Rubin, Baruch; Saha, Bipul; Shakil, Najam A

2016-01-13

To provide sufficient food and fiber to the increasing global population, the technologies associated with crop protection are growing ever more sophisticated but, at the same time, societal expectations for the safe use of crop protection chemistry tools are also increasing. The goal of this perspective is to highlight the key issues that face future leaders in crop protection, based on presentations made during a symposium titled "Developing Global Leaders for Research, Regulation and Stewardship of Crop Protection Chemistry in the 21st Century", held in conjunction with the IUPAC 13th International Congress of Pesticide Chemistry in San Francisco, CA, USA, during August 2014. The presentations highlighted the fact that leaders in crop protection must have a good basic scientific training and understand new and evolving technologies, are aware of the needs of both developed and developing countries, and have good communication skills. Concern is expressed over the apparent lack of resources to meet these needs, and ideas are put forward to remedy these deficiencies.

Detecting Man-in-the-Middle Attacks against Transport Layer Security Connections with Timing Analysis

DTIC Science & Technology

2011-09-15

Networks (VPNs), TLS protects massive amounts of private information, and protecting this data from Man-in-the-Middle ( MitM ) attacks is imperative to...keeping the information secure. This thesis illustrates how an attacker can successfully perform a MitM attack against a TLS connection without alerting...mechanism a user has against a MitM . The goal for this research is to determine if a time threshold exists that can indicate the presence of a MitM in this

Emerging research on real-time air pollution sensing with the United States Environmental Protection Agency, Office of Research and Development

EPA Science Inventory

Abstract: Air pollution research ranges broadly at the US EPA and includes the characterization of pollutant emissions from a wide array of sources, studying post-emission transport and transformation in the atmosphere, and evaluating the linkages between air pollution and advers...

Overview of current capabilities and research and technology developments for planetary protection

NASA Astrophysics Data System (ADS)

Frick, Andreas; Mogul, Rakesh; Stabekis, Pericles; Conley, Catharine A.; Ehrenfreund, Pascale

2014-07-01

The pace of scientific exploration of our solar system provides ever-increasing insights into potentially habitable environments, and associated concerns for their contamination by Earth organisms. Biological and organic-chemical contamination has been extensively considered by the COSPAR Panel on Planetary Protection (PPP) and has resulted in the internationally recognized regulations to which spacefaring nations adhere, and which have been in place for 40 years. The only successful Mars lander missions with system-level “sterilization” were the Viking landers in the 1970s. Since then different cleanliness requirements have been applied to spacecraft based on their destination, mission type, and scientific objectives. The Planetary Protection Subcommittee of the NASA Advisory Council has noted that a strategic Research & Technology Development (R&TD) roadmap would be very beneficial to encourage the timely availability of effective tools and methodologies to implement planetary protection requirements. New research avenues in planetary protection for ambitious future exploration missions can best be served by developing an over-arching program that integrates capability-driven developments with mission-driven implementation efforts. This paper analyzes the current status concerning microbial reduction and cleaning methods, recontamination control and bio-barriers, operational analysis methods, and addresses concepts for human exploration. Crosscutting research and support activities are discussed and a rationale for a Strategic Planetary Protection R&TD Roadmap is outlined. Such a roadmap for planetary protection provides a forum for strategic planning and will help to enable the next phases of solar system exploration.

INTERNATIONAL SOURCE WATER TOXICITY MONITORING CONSORTIUM

EPA Science Inventory

Many researchers in the field of time-relevant, on-line toxicity monitors for source water protection believe that some mechanism to guide and prioritize research in this emerging field would be beneficial. On-line toxicity monitors are tools designed to screen water quality and ...

40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection Research...

Early Impacts of Residential Development on Wood Thrushes in an Urbanizing Forest

Treesearch

L. E. Friesen; E. D. Cheskey; M. D. Cadman; V. E. Martin; R. J. MacKay

2005-01-01

Environmental protection policies sometimes protect forests along an advancing suburban front although many of the forests may be brought into close proximity to residential housing. Research suggests that even when forests are physically preserved, their bird communities are simplified as the surroundings become urbanized. However, little is known of the time required...

76 FR 16637 - J.N. “Ding” Darling NWR, Lee County, FL; Final Comprehensive Conservation Plan and Finding of No...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-24

..., quantity, and timing of flows and from climate change and sea level rise. Resource protection will be... designations, including Wilderness Area, Research Natural Area, Marine Protected Area, Florida Important Bird Area, and Outstanding Florida Water. Annual visitation to the refuge exceeds 700,000. We announce our...

Timely and Needed Perspectives on Differential Response in Child Protective Services

ERIC Educational Resources Information Center

Ellett, Alberta J.

2013-01-01

This article is an invited commentary and analysis of the authors' completed systematic evaluation of Child Protective Services (CPS) differential response (DR) models. I write this commentary based on 25 years of public child welfare experience followed by 13 years as a social work professor and researcher. In their review of DR, the…

Protective Factors at School: Reciprocal Effects among Adolescents' Perceptions of the School Environment, Engagement in Learning, and Hope

ERIC Educational Resources Information Center

Van Ryzin, Mark J.

2011-01-01

Although some research suggests that schools can be a source of protective factors for students, the processes by which school environments impact students' behavior, performance and adjustment over time are not clear. Guided by both self-determination theory and hope theory, this article evaluated reciprocal effects among adolescent perceptions…

Working mothers, breastfeeding, and the law.

PubMed

Murtagh, Lindsey; Moulton, Anthony D

2011-02-01

Workplace barriers contribute to low rates of breastfeeding. Research shows that supportive state laws correlate with higher rates, yet by 2009, only 23 states had adopted any laws to encourage breastfeeding in the workplace. Federal law provided virtually no protection to working mothers until the 2010 enactment of the "reasonable break time" provision of the Patient Protection and Affordable Care Act. This provision nonetheless leaves many working mothers uncovered, requires break time only to pump for (not feed) children younger than 1 year, and exempts small employers that demonstrate hardship. Public health professionals should explore ways to improve legal support for all working mothers wishing to breastfeed. Researchers should identify the laws that are most effective and assist policymakers in translating them into policy.

Contrasting the ethical perspectives of biospecimen research among individuals with familial risk for hereditary cancer and biomedical researchers: implications for researcher training.

PubMed

Quinn, Gwendolyn P; Koskan, Alexis; Sehovic, Ivana; Pal, Tuya; Meade, Cathy; Gwede, Clement K

2014-07-01

While ethical concerns about participating in biospecimen research have been previously identified, few studies have reported the concerns among individuals with familial risk for hereditary cancer (IFRs). At the same time, biomedical researchers often lack training in discussing such concerns to potential donors. This study explores IFRs' and biomedical researchers' perceptions of ethical concerns about participating in biobanking research. In separate focus groups, IFRs and biomedical researchers participated in 90-min telephone focus groups. Focus group questions centered on knowledge about laws that protect the confidentiality of biospecimen donors, understanding of informed consent and study procedures, and preferences for being recontacted about potential incidental discovery and also study results. A total of 40 IFRs and 32 biomedical researchers participated in the focus groups. Results demonstrated discrepancies between the perceptions of IFRs and researchers. IFRs' concerns centered on health information protection; potential discrimination by insurers and employers; and preferences for being recontacted upon discovery of gene mutations or to communicate study results. Researchers perceived that participants understood laws protecting donors' privacy and (detailed study information outlined in the informed consent process), study outcomes were used to create a training tool kit to increase researchers' understanding of IFRs' concerns about biobanking.

Contrasting the Ethical Perspectives of Biospecimen Research Among Individuals with Familial Risk for Hereditary Cancer and Biomedical Researchers: Implications for Researcher Training

PubMed Central

Koskan, Alexis; Sehovic, Ivana; Pal, Tuya; Meade, Cathy; Gwede, Clement K.

2014-01-01

While ethical concerns about participating in biospecimen research have been previously identified, few studies have reported the concerns among individuals with familial risk for hereditary cancer (IFRs). At the same time, biomedical researchers often lack training in discussing such concerns to potential donors. This study explores IFRs' and biomedical researchers' perceptions of ethical concerns about participating in biobanking research. In separate focus groups, IFRs and biomedical researchers participated in 90-min telephone focus groups. Focus group questions centered on knowledge about laws that protect the confidentiality of biospecimen donors, understanding of informed consent and study procedures, and preferences for being recontacted about potential incidental discovery and also study results. A total of 40 IFRs and 32 biomedical researchers participated in the focus groups. Results demonstrated discrepancies between the perceptions of IFRs and researchers. IFRs' concerns centered on health information protection; potential discrimination by insurers and employers; and preferences for being recontacted upon discovery of gene mutations or to communicate study results. Researchers perceived that participants understood laws protecting donors' privacy and (detailed study information outlined in the informed consent process), study outcomes were used to create a training tool kit to increase researchers' understanding of IFRs' concerns about biobanking. PMID:24786355

An ecological framework for informing permitting decisions on scientific activities in protected areas

PubMed Central

Saarman, Emily T.; Owens, Brian; Murray, Steven N.; Weisberg, Stephen B.; Field, John C.; Nielsen, Karina J.

2018-01-01

There are numerous reasons to conduct scientific research within protected areas, but research activities may also negatively impact organisms and habitats, and thus conflict with a protected area’s conservation goals. We developed a quantitative ecological decision-support framework that estimates these potential impacts so managers can weigh costs and benefits of proposed research projects and make informed permitting decisions. The framework generates quantitative estimates of the ecological impacts of the project and the cumulative impacts of the proposed project and all other projects in the protected area, and then compares the estimated cumulative impacts of all projects with policy-based acceptable impact thresholds. We use a series of simplified equations (models) to assess the impacts of proposed research to: a) the population of any targeted species, b) the major ecological assemblages that make up the community, and c) the physical habitat that supports protected area biota. These models consider both targeted and incidental impacts to the ecosystem and include consideration of the vulnerability of targeted species, assemblages, and habitats, based on their recovery time and ecological role. We parameterized the models for a wide variety of potential research activities that regularly occur in the study area using a combination of literature review and expert judgment with a precautionary approach to uncertainty. We also conducted sensitivity analyses to examine the relationships between model input parameters and estimated impacts to understand the dominant drivers of the ecological impact estimates. Although the decision-support framework was designed for and adopted by the California Department of Fish and Wildlife for permitting scientific studies in the state-wide network of marine protected areas (MPAs), the framework can readily be adapted for terrestrial and freshwater protected areas. PMID:29920527

Use of human specimens in research: the evolving United States regulatory, policy, and scientific landscape

PubMed Central

Bledsoe, Marianna J.; Grizzle, William E.

2013-01-01

The use of human specimens in research has contributed to significant scientific and medical advancements. However, the development of sophisticated whole genome and informatics technologies and the increase in specimen and data sharing have raised new questions about the identifiability of specimens and the protection of participants in human specimen research. In the US, new regulations and policies are being considered to address these changes. This review discusses the current and proposed regulations as they apply to specimen research, as well as relevant policy discussions. It summarizes the ways that researchers and other stakeholders can provide their input to these discussions and policy development efforts. Input from all the stakeholders in specimen research will be essential for the development of policies that facilitate such research while at the same time protecting the rights and welfare of research participants. PMID:24639889

Research on thermal protection mechanism of forward-facing cavity and opposing jet combinatorial thermal protection system

NASA Astrophysics Data System (ADS)

Lu, Hai-Bo; Liu, Wei-Qiang

2014-04-01

Validated by the correlated experiments, a nose-tip with forward-facing cavity/opposing jet/the combinatorial configuration of forward-facing cavity and opposing jet thermal protection system (TPS) are investigated numerically. The physical mechanism of these TPS is discussed, and the cooling efficiency of them is compared. The combinatorial system is more suitable to be the TPS for the high speed vehicles which need fly under various flow conditions with long-range and long time.

Educational research at Johns Hopkins University School of Medicine: a grassroots development.

PubMed

Thomas, Patricia A; Wright, Scott M; Kern, David E

2004-10-01

The Divisions of General Internal Medicine at Johns Hopkins University School of Medicine have been a rich source of educational research. To better understand the facilitators and barriers to educational research within the divisions, the authors reviewed published educational research from the divisions published between 1995-2004 and examined the history, leadership decisions, and sentinel events that have allowed educational scholarship within the divisions to grow. The authors' analysis suggests a grassroots model of programmatic growth that includes a growing cadre of clinician-educator scholars, effective mentorship, a faculty development program, access to learners, access to research expertise, protected time for scholarship, some funding, and an institutional culture that stimulates scholarship. A medical education fellowship was integral to the model; fellows were first authors for 47% of reviewed manuscripts. Extramural funding has helped build an infrastructure that supports educational scholarship; however, only 12% of the publications have had extramural funding. Protected time for faculty is the characteristic of this model most at risk. While there has been a move toward more institutional support of educational research, it is clear that further growth in the educational research program will require noninstitutional resources.

Using mobile location data in biomedical research while preserving privacy.

PubMed

Goldenholz, Daniel M; Goldenholz, Shira R; Krishnamurthy, Kaarkuzhali B; Halamka, John; Karp, Barbara; Tyburski, Matthew; Wendler, David; Moss, Robert; Preston, Kenzie L; Theodore, William

2018-06-07

Location data are becoming easier to obtain and are now bundled with other metadata in a variety of biomedical research applications. At the same time, the level of sophistication required to protect patient privacy is also increasing. In this article, we provide guidance for institutional review boards (IRBs) to make informed decisions about privacy protections in protocols involving location data. We provide an overview of some of the major categories of technical algorithms and medical-legal tools at the disposal of investigators, as well as the shortcomings of each. Although there is no "one size fits all" approach to privacy protection, this article attempts to describe a set of practical considerations that can be used by investigators, journal editors, and IRBs.

What does it take to be a successful pediatric surgeon-scientist?

PubMed

Watson, Carey; King, Alice; Mitra, Shaheel; Shaaban, Aimen F; Goldstein, Allan M; Morowitz, Michael J; Warner, Brad W; Crombleholme, Timothy M; Keswani, Sundeep G

2015-06-01

The factors that contribute to success as a pediatric surgeon-scientist are not well defined. The purpose of this study is to define a group of NIH-funded pediatric surgeons, assess their academic productivity, and elucidate factors that have contributed to their success. Pediatric surgeons were queried in the NIH report database to determine NIH funding awarded. Academic productivity was then assessed. An online survey was then targeted to NIH-funded pediatric surgeons. Since 1988, 83 pediatric surgeon-investigators have received major NIH funding. Currently, there are 37 pediatric surgeons with 43 NIH-sponsored awards. The mean h-index of this group of pediatric surgeons was 18 ± 1.1, mean number of publications (since 2001) was 21 ± 2.1, and both increase commensurate with academic rank. In response to the survey, 81% engaged in research during their surgical residency, and 48% were mentored by a pediatric surgeon-scientist. More than 60% of respondents had significant protected time and financial support. Factors felt to be most significant for academic success included mentorship, perseverance, and protected time. Mentorship, perseverance, institutional commitment to protected research time, and financial support are considered to be important to facilitate the successes of pediatric surgeon-scientists. These results will be useful to aspiring pediatric surgeon-scientists and departments wishing to develop a robust research program. Copyright © 2015 Elsevier Inc. All rights reserved.

Levee Scour Protection for Storm Waves

NASA Astrophysics Data System (ADS)

Johnson, E.; Sustainable; Resiliency in Levee Scour Protection

2011-12-01

Earnest Johnson, Firat Y. Testik *, Nadarajah Ravichandran Civil Engineering, Clemson University, Clemson, SC, USA * Contact author ftestik@clemson.edu Levee failure due to scouring has been a prominent occurrence among intense storm surges and waves, giving rise to the implementation of various scour protection measures over the years. This study is to investigate the levee scour and to compare different scour protection measures on a model-levee system in a laboratory wave tank. The protection measures that are tested and compared for their effectiveness in this study include turf reinforcement mats, woven geotextiles, and core-locs. This is an ongoing research effort and experiments are currently being conducted with model levees constructed based upon the United States Army Corps of Engineers' levee design and construction guidelines under various simulated storm conditions. Parameters such as wave elevations, deformation time history of the floodwall, and the scour depth are measured in each test. The finding of this research will be translated to provide effective scour protection measures for robust levee designs.

REAL-TIME MODELING OF MOTOR VEHICLE EMISSIONS FOR ESTIMATING HUMAN EXPOSURES NEAR ROADWAYS

EPA Science Inventory

The United States Environmental Protection Agency's (EPA) National Exposure Research Laboratory is developing a real-time model of motor vehicle emissions to improve the methodology for modeling human exposure to motor vehicle emissions. The overall project goal is to develop ...

REAL-TIME REMOTE MONITORING OF DRINKING WATER QUALITY

EPA Science Inventory

Over the past eight years, the U.S. Environmental Protection Agency's (EPA) Office of Research and Development (ORD) has funded the testing and evaluation of various online "real-time" technologies for monitoring drinking water quality. The events of 9/11 and subsequent threats t...

42 CFR 84.53 - Service time; classification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Service time; classification. 84.53 Section 84.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of...

42 CFR 84.53 - Service time; classification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Service time; classification. 84.53 Section 84.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of...

42 CFR 84.53 - Service time; classification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Service time; classification. 84.53 Section 84.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of...

42 CFR 84.53 - Service time; classification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Service time; classification. 84.53 Section 84.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of...

42 CFR 84.53 - Service time; classification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Service time; classification. 84.53 Section 84.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of...

75 FR 50745 - Information Collection; National Survey on Recreation and the Environment (NSRE)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-17

... to: [email protected] . The public may inspect comments received at USDA Forest Service, Research...: H. Ken Cordell, Research Work Unit SRS-4953, 706-559-4263. Individuals who use telecommunication... 8 p.m., Eastern Standard Time, Monday through Friday. SUPPLEMENTARY INFORMATION: Title: National...

A rapid method for identifying and characterizing structural impacts using distributed sensors: An application for automotive pedestrian protection

NASA Astrophysics Data System (ADS)

Kim, Andrew C.

This research is motivated by recent activity to improve automotive safety, especially for pedestrians. In many parts of the world today, injuries and fatalities from road accidents are a significant problem. Safety features such as seat restraints and air bags provide considerable levels of protection for car occupants; however, no such protective measures currently exist for pedestrians. Drawing upon the success and effectiveness of occupant air bag systems, current research aims to develop similar devices for pedestrians. These active pedestrian protection systems deploy a safety feature such as an external air bag when a pedestrian is hit by a vehicle. Contact with the front bumper induces a body rotation that may result in a violent head collision. The deployable safety device provides a cushioning surface for the vulnerable pedestrian during impact. The challenge of such a system is an effective sensory unit that can rapidly and correctly discriminate pedestrian impacts from non-pedestrian ones. The fast kinematics of the automobile-pedestrian impact leaves a minimal amount of time for signal processing and computation. This research study focuses on a discrimination scheme that satisfies both the time and accuracy requirements for a proposed sensory system for pedestrian protection. A unique methodology was developed to identify structural impacts using dominant frequency features extracted from sensory data. Contact sensors mounted on the front bumper of an automobile measure the strain response from an impact event. The dominant frequencies obtained from these sensor signals are greatly influenced by the impact object's properties and can be used to discriminate between different objects. Extensive tests were conducted to gather sensor data and validate the proposed methodology and impact discrimination algorithm. Results of the impact tests indicate that the approach is sound, and the sensory system effectively identifies "pedestrian" impacts within a short period of time.

40 CFR 18.10 - Appointment of Special Research Consultants for Environmental Protection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Consultants for Environmental Protection. 18.10 Section 18.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.10 Appointment of Special Research Consultants for Environmental Protection. (a...

40 CFR 18.10 - Appointment of Special Research Consultants for Environmental Protection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Appointment of Special Research... PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.10 Appointment of Special Research Consultants for Environmental Protection. (a...

Labour Market Trends in the United States--Lessons We Can Learn. IAB Labour Market Research Topics No. 25.

ERIC Educational Resources Information Center

Werner, Heinz

On average, unemployed U.S. citizens remain jobless for much less time than their European counterparts do. The relatively low level of unemployment in the United States is attributable to two factors: a social protection system that offers far less protection than those in Western Europe do and a broad range of job openings. The fact that…

[Facilitating the diagnosis of depression and burnout by identifying demographic and work-related risk and protective factors among nurses].

PubMed

Ádám, Szilvia; Nistor, Anikó; Nistor, Katalin; Cserháti, Zoltán; Mészáros, Veronika

2015-08-09

Depression and burnout are frequent comorbidities among nurses. Despite similar symptoms, their management differ. Therefore, their timely diagnosis is essential. To identify demographic and work-related risk and protective factors of burnout and depression, and facilitate their diagnosis. A cross-sectional study among 1,713 nurses was carried out. Depression and burnout were assessed by the shortened Beck Depression Questionnaire and Maclach Burnout Inventory, respectively. Risk and protective factors were explored using t-tests and analysis of variance. The prevalence of depression and moderate-to-high burnout was 35.1% and 34-74%, respectively. Having a partner/child and longer employment in the outpatient setting protected from burnout. Lack of a partner and male sex emerged as risk factors of depression and depersonalisation, respectively. High prevalence of depression and burnout among nurses poses a significant public health issue. Familiarity with the disease-specific risk and protective factors identified in this research may facilitate timely diagnosis and effective disease management.

The Tension Between Data Sharing and the Protection of Privacy in Genomics Research

PubMed Central

Kaye, Jane

2014-01-01

Next-generation sequencing and global data sharing challenge many of the governance mechanisms currently in place to protect the privacy of research participants. These challenges will make it more difficult to guarantee anonymity for participants, provide information to satisfy the requirements of informed consent, and ensure complete withdrawal from research when requested. To move forward, we need to improve the current governance systems for research so that they are responsive to individual privacy concerns but can also be effective at a global level. We need to develop a system of e-governance that can complement existing governance systems but that places greater reliance on the use of technology to ensure compliance with ethical and legal requirements. These new governance structures must be able to address the concerns of research participants while at the same time ensuring effective data sharing that promotes public trust in genomics research. PMID:22404490

The tension between data sharing and the protection of privacy in genomics research.

PubMed

Kaye, Jane

2012-01-01

Next-generation sequencing and global data sharing challenge many of the governance mechanisms currently in place to protect the privacy of research participants. These challenges will make it more difficult to guarantee anonymity for participants, provide information to satisfy the requirements of informed consent, and ensure complete withdrawal from research when requested. To move forward, we need to improve the current governance systems for research so that they are responsive to individual privacy concerns but can also be effective at a global level. We need to develop a system of e-governance that can complement existing governance systems but that places greater reliance on the use of technology to ensure compliance with ethical and legal requirements. These new governance structures must be able to address the concerns of research participants while at the same time ensuring effective data sharing that promotes public trust in genomics research.

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1992-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1991-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

REAL-TIME MODELING AND MEASUREMENT OF MOBILE SOURCE POLLUTANT CONCENTRATIONS FOR ESTIMATING HUMAN EXPOSURES IN COMMUNITIES NEAR ROADWAYS

EPA Science Inventory

The United States Environmental Protection Agency's (EPA) National Exposure Research Laboratory (NERL) is pursuing a project to improve the methodology for real-time site specific modeling of human exposure to pollutants from motor vehicles. The overall project goal is to deve...

Application of real-time PCR to postharvest physiology – DNA isolation

USDA-ARS?s Scientific Manuscript database

Real-time PCR technology has been widely used in the postharvest plant physiology research. One of the difficulties to isolate DNA from plant martial and pathogen cells is the presence of rigid polysaccharide cell walls and capsules, which physically protect DNA from cell lysis. Many materials requi...

77 FR 39246 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

... Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict... Panel; Member Conflict: AIDS and AIDS Related Research. Date: July 30-31, 2012. Time: 10 a.m. to 5 p.m...

40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Qualifications for Environmental Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL...

40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Fellowships in the Agency are for the purpose of encouraging and promoting research, studies, and... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18...

Measuring benefits of protected area management: trends across realms and research gaps for freshwater systems.

PubMed

Adams, Vanessa M; Setterfield, Samantha A; Douglas, Michael M; Kennard, Mark J; Ferdinands, Keith

2015-11-05

Protected areas remain a cornerstone for global conservation. However, their effectiveness at halting biodiversity decline is not fully understood. Studies of protected area benefits have largely focused on measuring their impact on halting deforestation and have neglected to measure the impacts of protected areas on other threats. Evaluations that measure the impact of protected area management require more complex evaluation designs and datasets. This is the case across realms (terrestrial, freshwater, marine), but measuring the impact of protected area management in freshwater systems may be even more difficult owing to the high level of connectivity and potential for threat propagation within systems (e.g. downstream flow of pollution). We review the potential barriers to conducting impact evaluation for protected area management in freshwater systems. We contrast the barriers identified for freshwater systems to terrestrial systems and discuss potential measurable outcomes and confounders associated with protected area management across the two realms. We identify key research gaps in conducting impact evaluation in freshwater systems that relate to three of their major characteristics: variability, connectivity and time lags in outcomes. Lastly, we use Kakadu National Park world heritage area, the largest national park in Australia, as a case study to illustrate the challenges of measuring impacts of protected area management programmes for environmental outcomes in freshwater systems. © 2015 The Author(s).

Measuring benefits of protected area management: trends across realms and research gaps for freshwater systems

PubMed Central

Adams, Vanessa M.; Setterfield, Samantha A.; Douglas, Michael M.; Kennard, Mark J.; Ferdinands, Keith

2015-01-01

Protected areas remain a cornerstone for global conservation. However, their effectiveness at halting biodiversity decline is not fully understood. Studies of protected area benefits have largely focused on measuring their impact on halting deforestation and have neglected to measure the impacts of protected areas on other threats. Evaluations that measure the impact of protected area management require more complex evaluation designs and datasets. This is the case across realms (terrestrial, freshwater, marine), but measuring the impact of protected area management in freshwater systems may be even more difficult owing to the high level of connectivity and potential for threat propagation within systems (e.g. downstream flow of pollution). We review the potential barriers to conducting impact evaluation for protected area management in freshwater systems. We contrast the barriers identified for freshwater systems to terrestrial systems and discuss potential measurable outcomes and confounders associated with protected area management across the two realms. We identify key research gaps in conducting impact evaluation in freshwater systems that relate to three of their major characteristics: variability, connectivity and time lags in outcomes. Lastly, we use Kakadu National Park world heritage area, the largest national park in Australia, as a case study to illustrate the challenges of measuring impacts of protected area management programmes for environmental outcomes in freshwater systems. PMID:26460127

Determinants of the Rigor of State Protection Policies for Persons With Dementia in Assisted Living.

PubMed

Nattinger, Matthew C; Kaskie, Brian

2017-01-01

Continued growth in the number of individuals with dementia residing in assisted living (AL) facilities raises concerns about their safety and protection. However, unlike federally regulated nursing facilities, AL facilities are state-regulated and there is a high degree of variation among policies designed to protect persons with dementia. Despite the important role these protection policies have in shaping the quality of life of persons with dementia residing in AL facilities, little is known about their formation. In this research, we examined the adoption of AL protection policies pertaining to staffing, the physical environment, and the use of chemical restraints. For each protection policy type, we modeled policy rigor using an innovative point-in-time approach, incorporating variables associated with state contextual, institutional, political, and external factors. We found that the rate of state AL protection policy adoptions remained steady over the study period, with staffing policies becoming less rigorous over time. Variables reflecting institutional policy making, including legislative professionalism and bureaucratic oversight, were associated with the rigor of state AL dementia protection policies. As we continue to evaluate the mechanisms contributing to the rigor of AL protection policies, it seems that organized advocacy efforts might expand their role in educating state policy makers about the importance of protecting persons with dementia residing in AL facilities and moving to advance appropriate policies.

Indicators for Evaluating Community- and Societal-Level Risk and Protective Factors for Violence Prevention: Findings From a Review of the Literature.

PubMed

Armstead, Theresa L; Wilkins, Natalie; Doreson, Amanda

Programs geared toward preventing violence before it occurs at the community and societal levels of the social ecology are particularly challenging to evaluate. These programs are often focused on impacting the antecedents (or risk and protective factors) to violence, making it difficult to determine program success when solely relying on measures of violence reduction. The goal of this literature review is to identify indicators to measure risk and protective factors for violence that are accessible and measured at the community level. Indicators of community- and societal-level risk and protective factors from 116 articles are identified. These indicators strengthen violence prevention researchers' and practitioners' ability to detect proximal effects of violence prevention programs, practices, and policies, and provide timely feedback on the impact of their work. Thus, opportunities exist for violence prevention researchers to further study the associations between various indicators and different violent outcomes and to inform practitioner, evaluator, and funder developed logic models that include indicators of relevant risk and protective factors for crosscutting violence prevention measures and outcomes.

Advanced power system protection and incipient fault detection and protection of spaceborne power systems

NASA Technical Reports Server (NTRS)

Russell, B. Don

1989-01-01

This research concentrated on the application of advanced signal processing, expert system, and digital technologies for the detection and control of low grade, incipient faults on spaceborne power systems. The researchers have considerable experience in the application of advanced digital technologies and the protection of terrestrial power systems. This experience was used in the current contracts to develop new approaches for protecting the electrical distribution system in spaceborne applications. The project was divided into three distinct areas: (1) investigate the applicability of fault detection algorithms developed for terrestrial power systems to the detection of faults in spaceborne systems; (2) investigate the digital hardware and architectures required to monitor and control spaceborne power systems with full capability to implement new detection and diagnostic algorithms; and (3) develop a real-time expert operating system for implementing diagnostic and protection algorithms. Significant progress has been made in each of the above areas. Several terrestrial fault detection algorithms were modified to better adapt to spaceborne power system environments. Several digital architectures were developed and evaluated in light of the fault detection algorithms.

A Systematic Review of Community Engagement in the US Environmental Protection Agency's Extramural Research Solicitations: Implications for Research Funders.

PubMed

Yuen, Tina; Park, Alice N; Seifer, Sarena D; Payne-Sturges, Devon

2015-12-01

We systematically reviewed the Environmental Protection Agency, National Center for Environmental Research's (NCER's) requests for applications (RFAs) and identified strategies that NCER and other funders can take to bolster community engagement. We queried NCER's publically available online archive of funding opportunities from fiscal years 1997 to 2013. From an initial list of 211 RFAs that met our inclusion criteria, 33 discussed or incorporated elements of community engagement. We examined these RFAs along 6 dimensions and the degree of alignments between them. We found changes over time in the number of RFAs that included community engagement, variations in how community engagement is defined and expected, inconsistencies between application requirements and peer review criteria, and the inclusion of mechanisms supporting community engagement in research. The results inform a systematic approach to developing RFAs that support community engagement in research.

Bridging the Gap: Supporting Translational Research Careers Through an Integrated Research Track Within Residency Training

PubMed Central

Arbuckle, Melissa R.; Gordon, Joshua A.; Pincus, Harold A.; Oquendo, Maria A.

2013-01-01

In the setting of traditional residency training programs, physician–scientists are often limited in their ability to pursue research training goals while meeting clinical training requirements. This creates a gap in research training at a critical developmental stage. In response, Columbia University Medical Center’s Department of Psychiatry, in partnership with the New York State Psychiatric Institute, has created a formal Research Track Program (RTP) for psychiatry residents so that interested individuals can maintain their attention on research training during formative residency years. Clinical and research training are integrated through core clinical rotations on research units. With protected research time and clear developmental milestones for each year of training, the RTP allows research track residents to meet both clinical and research training goals while maintaining a healthy work–life balance. In coordination with existing postdoctoral research fellowship programs, research track residents can effectively jump-start fellowship training with advanced course work and consistent, continuous mentorship bridging residency and fellowship years. A key element of the program is its provision of core training in research literacy and extensive research opportunities for all residents, stimulating research interest across the whole residency program. Supported by the National Institutes of Health and a private foundation, this RTP capitalizes on a unique academic–private partnership to address many of the challenges facing physician–scientists. By integrating clinical and research exposures and offering protected research time, careful mentoring, and financial resources, the program aims to further the development of those most poised to establish careers in translational research. PMID:23619070

A functionalist account of shame-induced behaviour.

PubMed

de Hooge, Ilona E; Zeelenberg, Marcel; Breugelmans, Seger M

2011-08-01

Recent research has shown that shame activates both a restore and a protect motive (De Hooge, Zeelenberg, & Breugelmans, 2010), explaining the hitherto unexpected finding that shame can lead to both approach and avoidance behaviours. In the present article we show a clear difference in priority and development of restore and protect motives over time. Our experiment reveals that shame mainly motivates approach behaviour to restore the damaged self, but that this restore motive decreases when situational factors make it too risky or difficult to restore. In contrast, the motive to protect one's damaged self from further harm is not influenced by such situational factors. As a consequence, the approach behaviour that shame activates may change over time. These findings add to our understanding of the motivational processes and behaviours following from shame.

Ethics and Regulatory Challenges and Opportunities in Patient-Centered Comparative Effectiveness Research.

PubMed

Sugarman, Jeremy

2016-04-01

The Affordable Care Act includes provisions for the conduct of large-scale, patient-centered comparative effectiveness research. Such efforts aim toward the laudable moral goal of having evidence to improve health care decision making. Nevertheless, these pragmatic clinical research efforts that typically pose minimal incremental risk and are enmeshed in routine care settings perhaps surprisingly encounter an array of ethics and regulatory challenges and opportunities for academic health centers. An emphasis on patient-centeredness forces an examination of the appropriateness of traditional methods used to protect the rights, interests, and welfare of participants. At the same time, meaningful collaboration with patients throughout the research process also necessitates ensuring that novel approaches to research (including recruitment and consent) entail necessary protections regarding such issues as privacy. As the scientific and logistical aspects of this research are being developed, substantial attention is being focused on the accompanying ethics and regulatory issues that have emerged, which should help to facilitate ethically appropriate research in a variety of contexts.

76 FR 4122 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... Committee: Allergy, Immunology, and Transplantation Research Committee. Date: February 23-24, 2011. Time: 8.... [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.855, Allergy, Immunology...

Linking research and policy to ensure children's environmental health.

PubMed Central

Goldman, L R

1998-01-01

The U.S. Environmental Protection Agency (U.S. EPA) has made protecting children's environmental health its highest priority. Data on how and when children may be at risk are vital for accomplishing this goal. Recent examples of the link between research and policy include U.S. EPA actions to carry out the recommendations of the National Academy of Sciences on pesticides in children's food, reduce and prevent childhood lead poisoning, and revise national ambient air quality standards for ozone and particulate matter. Today, the Food Quality Protection Act (FQPA), which makes protecting children from pesticide residues in food a national priority, is contributing to the growing need for data for decision making. Further impetus comes from provisions in the FQPA and 1996 Safe Drinking Water Act Amendments for establishing a screening and testing program for potential risks from endocrine disruptors. Another factor is the analysis that will be required under President William J. Clinton's executive order directing all federal agencies, for the first time, to reduce environmental health and safety risks to children. Success of the U.S. international commitment to protect children is directly tied to the strength and availability of environmental data. To meet such challenges, the U.S. EPA is revising key science policies, expanding research opportunities, and adding to the public's right-to-know tools. In this dynamic climate, there are growing opportunities for the research community to play a greater role in helping ensure the well-being of children living today and in generations to come. PMID:9646049

Immersion in a Hudson Valley Tidal Marsh and Climate Research Community - Lamont-Doherty's Secondary School Field Research Program

NASA Astrophysics Data System (ADS)

Peteet, D. M.; Newton, R.; Vincent, S.; Sambrotto, R.; Bostick, B. C.; Schlosser, P.; Corbett, J. E.

2015-12-01

A primary advantage of place-based research is the multidisciplinary and interdisciplinary research that can be applied to a single locale, with a depth of continued study through time. Through the last decade, Lamont-Doherty's Secondary School Field Research Program (SSFRP) has promoted scientific inquiry, mostly among groups under-represented in STEM fields, in Piermont Marsh, a federally protected marsh in the Hudson estuary. At the same time, Lamont Doherty Earth Observatory (LDEO) scientists have become more involved, through mentoring by researchers, postdocs and graduate students, often paired with high school teachers. The sustained engagement of high school students in a natural environment, experiencing the Hudson River and its tidal cycles, protection of coastline, water quality improvement, native and invasive plant communities, is fundamental to their understanding of the importance of wetlands with their many ecosystem services. In addition, the Program has come to see "place" as inclusive of the Observatory itself. The students' work at Lamont expands their understanding of educational opportunities and career possibilities. Immersing students in a research atmosphere brings a level of serious inquiry and study to their lives and provides them with concrete contributions that they make to team efforts. Students select existing projects ranging from water quality to Phragmites removal, read papers weekly, take field measurements, produce lab results, and present their research at the end of six weeks. Ongoing results build from year to year in studies of fish populations, nutrients, and carbon sequestration, and the students have presented at professional scientific meetings. Through the Program students gain a sense of ownership over both their natural and the academic environments. Challenges include sustained funding of the program; segmenting the research for reproducible, robust results; fitting the projects to PIs' research goals, time management, and institutionalization.

Evaluation of an Online Alcohol Education Program for First-Time-in-College Students

ERIC Educational Resources Information Center

Reiss, Elayne

2011-01-01

This study was guided by a research question regarding the efficacy of the AlcoholEdu program in increasing the use of protective behaviors among incoming college freshman of different drinking risk groups. Specifically, the researcher sought to determine which drinker risk groups, if any, showed the greatest degree of willingness to change…

Scientific integrity: critical issues in environmental health research

PubMed Central

Merlo, Domenico Franco; Vahakangas, Kirsi; Knudsen, Lisbeth E

2008-01-01

Environmental health research is a relatively new scientific area with much interdisciplinary collaboration. Regardless of which human population is included in field studies (e.g., general population, working population, children, elderly, vulnerable sub-groups, etc.) their conduct must guarantee well acknowledged ethical principles. These principles, along with codes of conduct, are aimed at protecting study participants from research-related undesired effects and guarantee research integrity. A central role is attributed to the need for informing potential participants (i.e., recruited subjects who may be enrolled in a study), obtaining their written informed consent to participate, and making them aware of their right to refuse to participate at any time and for any reason. Data protection is also required and communication of study findings must respect participant's willingness to know or not know. This is specifically relevant for studies including biological markers and/or storing biological samples that might be analysed years later to tackle research objectives that were specified and communicated to participants at the time of recruitment or that may be formulated after consent was obtained. Integrity is central to environmental health research searching for causal relations. It requires open communication and trust and any violation (i.e., research misconduct, including fabrication or falsification of data, plagiarism, conflicting interests, etc.) may endanger the societal trust in the research community as well as jeopardize participation rates in field projects. PMID:18541075

Evaluation of Electrical Characteristics of Protective Equipment - a Prerequisite for Ensuring Safety and Health of Workers at Work

NASA Astrophysics Data System (ADS)

Buică, G.; Beiu, C.; Antonov, A.; Dobra, R.; Păsculescu, D.

2017-06-01

The protecting electrical equipment in use are subject to various factors generated by the use, maintenance, storage and working environment, which may change the characteristics of protection against electric shock. The study presents the results of research on the behaviour over time of protective characteristics of insulating covers of material of work equipment in use, in order to determine the type and periodicity of safety tests. There were tested and evaluated safety equipment with plastic and insulating rubber covers used in operations of verifying functionality, safety and maintenance of machinery used in manufacturing industries and specific services from electric, energy and food sector.

International Data Sharing in Practice: New Technologies Meet Old Governance.

PubMed

Murtagh, Madeleine J; Turner, Andrew; Minion, Joel T; Fay, Michaela; Burton, Paul R

2016-06-01

The social structures that govern data/sample release aim to safeguard the confidentiality and privacy of cohort research participants (without whom there would be no data or samples) and enable the realization of societal benefit through optimizing the scientific use of those cohorts. Within collaborations involving multiple cohorts and biobanks, however, the local, national, and supranational institutional and legal guidelines for research (which produce a multiplicity of data access governance structures and guidelines) risk impeding the very science that is the raison d'etre of these consortia. We present an ethnographic study, which examined the epistemic and nonepistemic values driving decisions about data access and their consequences in the context of the pilot of an integrated approach to co-analysis of data. We demonstrate how the potential analytic flexibility offered by this approach was lost under contemporary data access governance. We identify three dominant values: protecting the research participant, protecting the study, and protecting the researcher. These values were both supported by and juxtaposed against a "public good" argument, and each was used as a rationale to both promote and inhibit sharing of data. While protection of the research participants was central to access permissions, decisions were also attentive to the desire of researchers to see their efforts in building population biobanks and cohorts realized in the form of scientific outputs. We conclude that systems for governing and enabling data access in large consortia need to (1) protect disclosure of research participant information or identity, (2) ensure the specific expectations of research participants are met, (3) embody systems of review that are transparent and not compromised by the specific interests of one particular group of stakeholders, and (4) facilitate data access procedures that are timely and efficient. Practical solutions are urgently needed. New approaches to data access governance should be trialed (and formally evaluated) with input from and discussion with stakeholders.

The Myth, the Truth, the NASA IRB

NASA Technical Reports Server (NTRS)

Covington, M. D.; Flores, M. P.; Neutzler, V. P.; Schlegel, T. T.; Platts, S. H.; Lioyd, C. W.

2017-01-01

The purpose of the NASA Institutional Review Board (IRB) is to review research activities involving human subjects to ensure that ethical standards for the care and protection of human subjects have been met and research activities are in compliance with all pertinent federal, state and local regulations as well as NASA policies. NASA IRB's primary role is the protection of human subjects in research studies. Protection of human subjects is the shared responsibility of NASA, the IRB, and the scientific investigators. Science investigators who plan to conduct NASA-funded human research involving NASA investigators, facilities, or funds must submit and coordinate their research studies for review and approval by the NASA IRB prior to initiation. The IRB has the authority to approve, require changes in, or disapprove research involving human subjects. Better knowledge of the NASA IRB policies, procedures and guidelines should help facilitate research protocol applications and approvals. In this presentation, the myths and truths of NASA IRB policies and procedures will be discussed. We will focus on the policies that guide a protocol through the NASA IRB and the procedures that principal investigators must take to obtain required IRB approvals for their research studies. In addition, tips to help ensure a more efficient IRB review will be provided. By understanding the requirements and processes, investigators will be able to more efficiently prepare their protocols and obtain the required NASA IRB approval in a timely manner.

Reusable thermal protection system development: A prospective

NASA Technical Reports Server (NTRS)

Goldstein, Howard

1992-01-01

The state of the art in passive reusable thermal protection system materials is described. Development of the Space Shuttle Orbiter, which was the first reusable vehicle, is discussed. The thermal protection materials and given concepts and some of the shuttle development and manufacturing problems are described. Evolution of a family of grid and flexible ceramic external insulation materials from the initial shuttle concept in the early 1970's to the present time is described. The important properties and their evolution are documented. Application of these materials to vehicles currently being developed and plans for research to meet the space programs future needs are summarized.

Exposure Assessment of Livestock Carcass Management ...

EPA Pesticide Factsheets

Technical Brief This research brief summarizes an evaluation of livestock carcass management options following a natural disaster through a comparative exposure assessment. This assessment helps to inform a scientifically-based selection of environmentally protective methods in times of emergency.

Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL)

DTIC Science & Technology

2016-06-01

The current study identified optimal protective D-methionine (D-met) dose and delayed time response from steady state and impulse noise -induced hearing loss (NIHL) in groups of Chinchillas laniger (n=10/group).

Child protection: a 50-year perspective.

PubMed

Skellern, Catherine Yvette

2015-01-01

It has been 50 years since Kempe et al. published 'The Battered Child Syndrome', describing harm from inflicted injury mechanisms derived from parents and care givers. Since then, there has emerged a rapidly expanding literature on paediatric forensic medicine and child protection, which has offered new insights into injury mechanisms, informed us of the sequelae of abuse and neglect, aided diagnosis and guided clinical practice in the treatment and management of children who become involved in the child protection system. Through the scrutiny of government inquiries and at times uncomfortable media exposure, there have been improvements in child protection and forensic practices resulting in recognition of need for specialised forensic training, improved funding, development of resources and development of professional standards that support accountable, objective, safe and robust practice. From the perspective of an Australian child protection paediatrician, this paper chronicles some of the most significant and at times controversial research in the last 50 years in child protection that have played a key role in shaping our current understanding of child abuse and neglect. © 2014 The Author. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Assessment of Translational and Interdisciplinary Clinical Research at an Oklahoma Health Sciences Center

PubMed Central

Dao, Hanh Dung; Kota, Pravina; James, Judith A.; Stoner, Julie A.; Akins, Darrin R.

2015-01-01

Purpose In response to National Institutes of Health initiatives to improve translation of basic science discoveries we surveyed faculty to assess patterns of and barriers to translational research in Oklahoma. Methods An online survey was administered to University of Oklahoma Health Sciences Center, College of Medicine faculty, which included demographic and research questions. Results Responses were received from 126 faculty members (24%). Two-thirds spent ≥20% time on research; among these, 90% conduct clinical and translational research. Identifying funding; recruiting research staff and participants; preparing reports and agreements; and protecting research time were commonly perceived as at least moderate barriers to conducting research. While respondents largely collaborated within their discipline, clinical investigators were more likely than basic science investigators to engage in interdisciplinary research. Conclusion While engagement in translational research is common, specific barriers impact the research process. This could be improved through an expanded interdisciplinary collaboration and research support structure. PMID:26242016

Next Generation Scientists, Next Opportunities: EPA's Science To Achieve Results (STAR) Program

NASA Astrophysics Data System (ADS)

Jones, M.

2004-12-01

Scientific research is one of the most powerful tools we have for understanding and protecting our environment. It provides the foundation for what we know about our planet, how it has changed, and how it could be altered in the future. The National Center for Environmental Research (NCER) in the U.S. Environmental Protection Agency's (EPA) Office of Research and Development (ORD) supports high-quality, extramural research by the nation's leading scientists and engineers to strengthen the basis for decisions about local and national environmental issues. NCER works with academia, state and local governments, other federal agencies, and scientists in EPA to increase human knowledge of how to protect our health and natural resources through its three major programs: · Science to Achieve Results (STAR) Grants · Small Business Innovative Research (SBIR) · Science to Achieve Results (STAR) Fellowships STAR, NCER's primary program, funds research grants and graduate fellowships in environmental science and engineering. Developing the next generation of environmental scientists and engineers is one of NCER's most important objectives. Each year, NCER helps between 80 and 160 students achieve Master's or Ph.D. degrees in environmental science and engineering through its STAR and Greater Research Opportunities (GRO) fellowships. Some of these students have moved on to careers in government while others are now full-time professors and researchers. Still others are working for state environmental agencies or furthering their studies through postdoctoral positions at universities. Since the inception of the NCER program, STAR fellowships (along with grants and SBIR projects) have been awarded in every state in the country. With the help of STAR, current and future scientists and engineers have been able to explore ways to preserve and protect human health and our precious resources.

40 CFR 18.2 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.2 Applicability. The regulations in this part apply to the establishment of Environmental Protection Research Fellowships, the...

40 CFR 18.2 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.2 Applicability. The regulations in this part apply to the establishment of Environmental Protection Research Fellowships, the...

The protective role of self-efficacy against workplace incivility and burnout in nursing: A time-lagged study.

PubMed

Fida, Roberta; Laschinger, Heather K Spence; Leiter, Michael P

Incivility has negative consequences in the workplace and remains a prevalent issue in nursing. Research has consistently linked incivility to nurse burnout and, in turn, to poor mental health and turnover intentions. To retain high-quality nurses, it is important to understand what factors might protect nurses from the negative effects of workplace mistreatment. The aim of the study was to investigate the role of relational occupational coping self-efficacy in protecting nurses from workplace incivility and related burnout and turnover intentions. A two-wave national sample of 596 Canadian nurses completed mail surveys both at Time 1 and one year later at Time 2. Structural equation modeling was used to test the hypothesized model. The model showed a good fit, and most of the hypothesized paths were significant. Overall, the results supported the hypothesized protective effect of relational occupational coping self-efficacy against incivility and later burnout, mental health, and turnover intentions. Relational occupational coping self-efficacy is an important protective factor against negative work behavior. Organizations should provide nurses with opportunities to build their coping strategies for managing job demands and difficult interpersonal interactions. Similarly, providing exposure to effective role models and providing meaningful verbal encouragement are other sources of efficacy information for building nurses' relational coping self-efficacy.

Forewarning reduces fraud susceptibility in vulnerable consumers

PubMed Central

Scheibe, Susanne; Notthoff, Nanna; Menkin, Josephine; Ross, Lee; Shadel, Doug; Deevy, Martha; Carstensen, Laura L.

2014-01-01

Telemarketing fraud is pervasive and older consumers are disproportionally targeted. Given laboratory research showing that forewarning can effectively counter influence appeals, we conducted a field experiment to test whether forewarning could protect people who had been victimized in the past. A research assistant with prior experience as a telemarketer pitched a mock scam two or four weeks after participants were warned about the same scam or an entirely different scam. Both warnings reduced unequivocal acceptance of the mock scam although outright refusals (as opposed to expressions of skepticism) were more frequent with the same scam warning than the different scam warning. The same scam warning, but not the different scam warning, lost effectiveness over time. Findings demonstrate that social psychological research can inform effective protection strategies against telemarketing fraud. PMID:25328263

Longitudinal Associations Among Religiousness, Delay Discounting, and Substance Use Initiation in Early Adolescence.

PubMed

Kim-Spoon, Jungmeen; McCullough, Michael E; Bickel, W K; Farley, Julee P; Longo, Gregory S

2015-03-01

Prior research indicates that religiousness is related negatively to adolescent health risk behaviors, yet how such protective effects operate is not well understood. This study examined the longitudinal associations among organizational and personal religiousness, delay discounting, and substance use initiation (alcohol, cigarette, and marijuana use). The sample comprised 106 early adolescents (10-13 years of age, 52% female) who were not using substances at Time 1. Path analyses suggested that high levels of personal religiousness at Time 1 were related to low levels of substance use at Time 2 (2.4 years later), mediated by low levels of delay discounting. Delay discounting appears to be an important contributor to the protective effect of religiousness on the development of substance use among adolescents.

The effect of protected sardine fish oil as feed supplement on ruminal fermentation

NASA Astrophysics Data System (ADS)

Pramono, A.; Widayati, D. T.; Handayanta, E.

2018-03-01

The research aims to evaluate the influence of protected sardine fish oil as feed supplement on ruminal fermentation (pH rumen fluid, ammonia concentration and volatile fatty acids production in the rumen). Protected feed supplement was produced from sardine fish oil and soybean meal, through two protection methods, they were saponification and microencapsulation. The experiment consists of two treatments i.e. P0: basal diet (control) and P1: basal diet + 3 % protected feed supplement. Each treatment was repeated 10 times. The kinetics observation of the pH rumen fluid, ammonia concentration and volatile fatty acids production were performed at incubation times 0, 2, 4 and 6 hours respectively. Data were analyzed using independent samples t-test. Results in cow with protected feed supplement showed that kinetics of pH rumen fluid: 7.23; 7.13; 6.90 and 6.76 respectively; ruminal ammonia concentration: 26.70; 31.06; 19.75 and 15.52 respectively; and volatile fatty acids production: 22.75; 26.08; 29.19 and 25.79 respectively. The results could be concluded that the effect of supplementation of protected sardine fish oil have an optimal of pH rumen fluid, ammonia concentration, and volatile fatty acids production so it did not interfere the ruminal fermentation in the rumen.

77 FR 829 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-06

... Research Systems, Inc. (``FactSet') and Thomson Reuters (``Reuters''). Real time data is distributed at... series. As stated in the filing, the Exchange has rules in place designed to protect public customer... are long term options that generally expire from twelve to thirty-nine months from the time they are...

78 FR 15753 - Maintenance, Testing, and Replacement of Vented Lead-Acid Storage Batteries for Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

.... Although a time limit is given, comments and suggestions in connection with items for inclusion in guides currently being developed or improvements in all published guides are encouraged at any time. ADDRESSES: You...: 301-251-7455, or by email: [email protected] . Both of the Office of Nuclear Regulatory Research...

76 FR 44512 - Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... research enterprise, the proliferation of multi-site clinical trials and observational studies, the... and Drug Administration 21 CFR Parts 50 and 56 Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing Burden, Delay, and Ambiguity for Investigators AGENCIES: The...

78 FR 10538 - Protections for Subjects in Human Research Involving Pesticides

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-14

... the basis of animal data or human observational research. (2) Whether the proposed research is... Protections for Subjects in Human Research Involving Pesticides AGENCY: Environmental Protection Agency (EPA... for the protection of human subjects of research applying to third parties who conduct or support...

A Systematic Review of Community Engagement in the US Environmental Protection Agency’s Extramural Research Solicitations: Implications for Research Funders

PubMed Central

Yuen, Tina; Park, Alice N.; Seifer, Sarena D.

2015-01-01

Objectives. We systematically reviewed the Environmental Protection Agency, National Center for Environmental Research’s (NCER’s) requests for applications (RFAs) and identified strategies that NCER and other funders can take to bolster community engagement. Methods. We queried NCER’s publically available online archive of funding opportunities from fiscal years 1997 to 2013. From an initial list of 211 RFAs that met our inclusion criteria, 33 discussed or incorporated elements of community engagement. We examined these RFAs along 6 dimensions and the degree of alignments between them. Results. We found changes over time in the number of RFAs that included community engagement, variations in how community engagement is defined and expected, inconsistencies between application requirements and peer review criteria, and the inclusion of mechanisms supporting community engagement in research. Conclusions. The results inform a systematic approach to developing RFAs that support community engagement in research. PMID:26469656

Deep Space Gateway Science Opportunities

NASA Technical Reports Server (NTRS)

Quincy, C. D.; Charles, J. B.; Hamill, Doris; Sidney, S. C.

2018-01-01

The NASA Life Sciences Research Capabilities Team (LSRCT) has been discussing deep space research needs for the last two years. NASA's programs conducting life sciences studies - the Human Research Program, Space Biology, Astrobiology, and Planetary Protection - see the Deep Space Gateway (DSG) as affording enormous opportunities to investigate biological organisms in a unique environment that cannot be replicated in Earth-based laboratories or on Low Earth Orbit science platforms. These investigations may provide in many cases the definitive answers to risks associated with exploration and living outside Earth's protective magnetic field. Unlike Low Earth Orbit or terrestrial locations, the Gateway location will be subjected to the true deep space spectrum and influence of both galactic cosmic and solar particle radiation and thus presents an opportunity to investigate their long-term exposure effects. The question of how a community of biological organisms change over time within the harsh environment of space flight outside of the magnetic field protection can be investigated. The biological response to the absence of Earth's geomagnetic field can be studied for the first time. Will organisms change in new and unique ways under these new conditions? This may be specifically true on investigations of microbial communities. The Gateway provides a platform for microbiology experiments both inside, to improve understanding of interactions between microbes and human habitats, and outside, to improve understanding of microbe-hardware interactions exposed to the space environment.

Dietary Protected Feed Supplement to Increase Milk Production and Quality of Dairy Cows

NASA Astrophysics Data System (ADS)

Pramono, A.; Handayanta, E.; Widayati, D. T.; Putro, P. P.; Kustono

2017-04-01

The efforts to improve and optimize productivity of dairy cows require sufficient availability of nutrients, especially high energy in the early period of lactation. Increasing energy intake in dairy cows can be conducted by increasing the density of energy. The research aimed to evaluate dietary protected feed supplement on milk production and quality, including: fat, protein, and lactose content of Friesian Holstein dairy cow milk. Protected feed supplement was produced from sardine fish oil, through saponification and microencapsulation protection methods. The experiment consists of two treatments i.e. P0: basal diet (control) and P1: basal diet + 3 % protected feed supplement. Each treatment was repeated 15 times. Data were analyzed by independent samples t-test analysis. Results showed that supplementation of protected sardine fish oil had no effect on lactose content, but increased milk yield production (p<0.01), milk fat content (p<0.05), and protein content (p<0.05).

Using ToF-SIMS and EIS to evaluate green pretreatment reagent: Corrosion protection of aluminum alloy by silica/zirconium/cerium hybrid coating

NASA Astrophysics Data System (ADS)

Chang, Chun-Chao; Wang, Chiung-Chi; Wu, Chia-Wei; Liu, Shou-Ching; Mai, Fu-Der

2008-12-01

Increasing environmental concern has led to the restrictive use of chromate conversion coatings to protect Al-alloys from corrosion. Our research is under way to find environmentally compliant substitute coating such as Si/Zr/Ce hybrid coating. The corrosion protection effect of green pretreatment reagent consisted of Si-containing base solution, Ce- and Zr-containing sealing solutions on the corrosion protection of Al-alloys was studied with a 3.5% NaCl aqueous testing solution. The correlation between the corrosion resistance measured by electrochemical impedance spectroscopy (EIS) and surface chemical composition of the hybrid coating measured by time-of-flight secondary ion mass spectroscopy (ToF-SIMS) was studied. The proposed green pretreatment reagent was found improve the corrosion protection of Al-alloys, presumably due to the formation of protective oxide film acting as an oxygen barrier.

Defeating copper tolerance: an example of how “omics” research can accelerate discovery of new wood protection compounds

Treesearch

Juliet D. Tang; Tina Ciaramitaro; Darrel D. Nicholas; Maria Tomaso-Peterson; Susan V. Diehl

2017-01-01

Imagine if you could measure all the genes being expressed at any one time in an organism and you knew what all the genes did in a cell. The power of this knowledge would allow you to determine how organisms regulate gene activity to survive. This is the essence of how “omics” science accelerates biological understanding. From a wood protections standpoint,...

Risk and protective factors for sexual risk taking among adolescents involved in Prime Time.

PubMed

Garwick, Ann; Nerdahl, Peggy; Banken, Rachel; Muenzenberger-Bretl, Lynn; Sieving, Renee

2004-10-01

This article describes a preliminary qualitative evaluation of risk and protective factors associated with consistent contraceptive use and healthy sexual decision-making among ten of the first participants in the Prime Time intervention study. Prime Time is an 18-month intervention including one-on-one case management and peer educator training targeting sexually active 13-17-year-old girls who are recruited from health care clinics. Using an approach grounded in findings from previous research, social cognitive theory, and the social development model, Prime Time aims to improve participants' contraceptive use consistency, reduce number of sexual partners, and reduce unwanted sexual activity. Findings from this preliminary evaluation alert health care providers to the complex and dynamic nature of adolescent girls' sexual behaviors and to a broad range of risk and protective factors within individuals and their environments that may influence adolescent girls' sexual behaviors and contraceptive use. Findings suggest that an ongoing, supportive relationship with a case manager who is able to pace and tailor an intervention to the individual young person can have positive effects on adolescent girls' sexual behaviors and contraceptive use.

Research supporting potential modification of the NASA specification for dry heat microbial reduction of spacecraft hardware

NASA Astrophysics Data System (ADS)

Spry, James A.; Beaudet, Robert; Schubert, Wayne

Dry heat microbial reduction (DHMR) is the primary method currently used to reduce the microbial load of spacecraft and component parts to comply with planetary protection re-quirements. However, manufacturing processes often involve heating flight hardware to high temperatures for purposes other than planetary protection DHMR. At present, the specifica-tion in NASA document NPR8020.12, describing the process lethality on B. atrophaeus (ATCC 9372) bacterial spores, does not allow for additional planetary protection bioburden reduction credit for processing outside a narrow temperature, time and humidity window. Our results from a comprehensive multi-year laboratory research effort have generated en-hanced data sets on four aspects of the current specification: time and temperature effects in combination, the effect that humidity has on spore lethality, and the lethality for spores with exceptionally high thermal resistance (so called "hardies"). This paper describes potential modifications to the specification, based on the data set gener-ated in the referenced studies. The proposed modifications are intended to broaden the scope of the current specification while still maintaining confidence in a conservative interpretation of the lethality of the DHMR process on microorganisms.

Associations between authoritative parenting and the sun exposure and sun protective behaviours of adolescents and their friends.

PubMed

Mewse, Avril J; Lea, Stephen E G; Ntala, Eleni; Eiser, J Richard

2011-05-01

Associations between the sun exposure and sun protective behaviours of adolescents and their friends were examined along with the role played by authoritative parenting and other family and peer socialisation factors. Four hundred and two adolescents (198 males, 204 females) participated in the research. It was found that these adolescents and their friends shared similar sun exposure and sun protective behaviours and had similar parenting backgrounds. Parental authoritativeness was positively associated with the use of sun protection, even after the effects of other familial and peer variables were controlled, but not with the time spent sunbathing which was associated with friends' behaviours. The theoretical and practical implications of these findings are discussed.

Predictors of justice system involvement: Maltreatment and education.

PubMed

Robertson, Angela A; Walker, Courtney S

2018-02-01

Decades of research have established that experience of abuse and/or neglect in childhood is related to negative outcomes, such as juvenile delinquency. Existing research has shown that involvement in child welfare services is also related to juvenile delinquency, particularly for children who are victims of neglect. Research has also identified educational factors such as chronic absenteeism as significant predictors of involvement in the juvenile justice system. However, little research has investigated the combined influence of educational factors, child abuse, and involvement in child protective services on justice system involvement. The current study examined the influence of educational factors and involvement in child protective services on justice system involvement. The study utilized records from an educational database of children who attended a school within a county of Mississippi in any year from 2003 through 2013. Cases were then matched with records from the county Youth Court, Law Enforcement agencies, and Child Protection Services. A multivariate logistic regression controlling for gender, race, current age, and time at risk was conducted to involvement in the justice system. In general, educational factors were stronger predictors of justice system involvement than allegations of maltreatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

[INDENA SPA company's patent portfolio of Ginkgo biloba preparation].

PubMed

Wang, Nan; Guo, Kai; Cheng, Xin-min; Liu, Wei

2015-10-01

INDENA SPA Company in Italy is a multi-national company that produces and sells plant extracts. Based on its own re- search advantages in the field of Ginkgo biloba preparation, the company protects its own products market effectively through building patent portfolio around the patents of its opponent. Based on the multi-angle analysis for patent portfolio of G. biloba preparation from the aspects of application time, legal status, technical development route, and patent portfolio layout, this article provides technical reference on research and development of G. biloba preparation, and the author suggest that Chinese applicants learn techniques and layout experiences of other patents fully to enhance the level of research and patent protection level.

National nanotechnology partnership to protect workers

NASA Astrophysics Data System (ADS)

Howard, John; Murashov, Vladimir

2009-10-01

Nanotechnology is predicted to improve many aspects of human life. By 2015, it is estimated to represent 3.1 trillion in manufactured goods. Data is emerging that exposure to nanomaterials may pose a health risk to workers. If the economic promise of nanotechnology is to be achieved, ways need to be found to protect nanotechnology workers now. The Occupational Safety and Health Act of 1970 (OSHAct) gave the responsibility to protect workers to the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) through research, standards adoption, and standards enforcement. Since 1980, adopting new occupational health standards has grown more complex. The increased complexity has greatly slowed efforts to adopt protective standards for toxic agents that are well-known to pose significant risks. The likelihood of rapidly adopting standards to protect workers from nanomaterials, whose risks are just emerging, seems even more unlikely. Use of the OSHAct's general duty clause to protect workers also seems uncertain at this time. In the interim, a national partnership led by NIOSH involving nanotech manufacturers and downstream users, workers, academic researchers, safety, and health practitioners is proposed. A National Nanotechnology Partnership would generate knowledge about the nature and the extent of worker risk, utilize that knowledge to develop risk control strategies to protect nanotechnology workers now, and provide an evidence base for NIOSH recommendations to OSHA for a nanotechnology program standard at a future date.

40 CFR 18.8 - Stipends, Allowances, and Benefits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... to some other place at no greater cost to the Government. An Environmental Protection Research fellow....8 Section 18.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.8 Stipends...

Privacy and Security in Mobile Health (mHealth) Research.

PubMed

Arora, Shifali; Yttri, Jennifer; Nilse, Wendy

2014-01-01

Research on the use of mobile technologies for alcohol use problems is a developing field. Rapid technological advances in mobile health (or mHealth) research generate both opportunities and challenges, including how to create scalable systems capable of collecting unprecedented amounts of data and conducting interventions-some in real time-while at the same time protecting the privacy and safety of research participants. Although the research literature in this area is sparse, lessons can be borrowed from other communities, such as cybersecurity or Internet security, which offer many techniques to reduce the potential risk of data breaches or tampering in mHealth. More research into measures to minimize risk to privacy and security effectively in mHealth is needed. Even so, progress in mHealth research should not stop while the field waits for perfect solutions.

40 CFR 18.10 - Appointment of Special Research Consultants for Environmental Protection.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Purpose. When the EPA requires the services of consultants with expertise in environmental sciences or... Consultants for Environmental Protection. 18.10 Section 18.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR...

40 CFR 18.10 - Appointment of Special Research Consultants for Environmental Protection.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Purpose. When the EPA requires the services of consultants with expertise in environmental sciences or... Consultants for Environmental Protection. 18.10 Section 18.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR...

40 CFR 18.10 - Appointment of Special Research Consultants for Environmental Protection.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Purpose. When the EPA requires the services of consultants with expertise in environmental sciences or... Consultants for Environmental Protection. 18.10 Section 18.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR...

A missing dimension in measures of vaccination impacts

USGS Publications Warehouse

Gomes, M. Gabriela M.; Lipsitch, Marc; Wargo, Andrew R.; Kurath, Gael; Rebelo, Carlota; Medley, Graham F.; Coutinho, Antonio

2013-01-01

Immunological protection, acquired from either natural infection or vaccination, varies among hosts, reflecting underlying biological variation and affecting population-level protection. Owing to the nature of resistance mechanisms, distributions of susceptibility and protection entangle with pathogen dose in a way that can be decoupled by adequately representing the dose dimension. Any infectious processes must depend in some fashion on dose, and empirical evidence exists for an effect of exposure dose on the probability of transmission to mumps-vaccinated hosts [1], the case-fatality ratio of measles [2], and the probability of infection and, given infection, of symptoms in cholera [3]. Extreme distributions of vaccine protection have been termed leaky (partially protects all hosts) and all-or-nothing (totally protects a proportion of hosts) [4]. These distributions can be distinguished in vaccine field trials from the time dependence of infections [5]. Frailty mixing models have also been proposed to estimate the distribution of protection from time to event data [6], [7], although the results are not comparable across regions unless there is explicit control for baseline transmission [8]. Distributions of host susceptibility and acquired protection can be estimated from dose-response data generated under controlled experimental conditions [9]–[11] and natural settings [12], [13]. These distributions can guide research on mechanisms of protection, as well as enable model validity across the entire range of transmission intensities. We argue for a shift to a dose-dimension paradigm in infectious disease science and community health.

Information processing capacity while wearing personal protective eyewear.

PubMed

Wade, Chip; Davis, Jerry; Marzilli, Thomas S; Weimar, Wendi H

2006-08-15

It is difficult to overemphasize the function vision plays in information processing, specifically in maintaining postural control. Vision appears to be an immediate, effortless event; suggesting that eyes need only to be open to employ the visual information provided by the environment. This study is focused on investigating the effect of Occupational Safety and Health Administration regulated personal protective eyewear (29 CFR 1910.133) on physiological and cognitive factors associated with information processing capabilities. Twenty-one college students between the ages of 19 and 25 years were randomly tested in each of three eyewear conditions (control, new and artificially aged) on an inclined and horizontal support surface for auditory and visual stimulus reaction time. Data collection trials consisted of 50 randomly selected (25 auditory, 25 visual) stimuli over a 10-min surface-eyewear condition trial. Auditory stimulus reaction time was significantly affected by the surface by eyewear interaction (F2,40 = 7.4; p < 0.05). Similarly, analysis revealed a significant surface by eyewear interaction in reaction time following the visual stimulus (F2,40 = 21.7; p < 0.05). The current findings do not trivialize the importance of personal protective eyewear usage in an occupational setting; rather, they suggest the value of future research focused on the effect that personal protective eyewear has on the physiological, cognitive and biomechanical contributions to postural control. These findings suggest that while personal protective eyewear may serve to protect an individual from eye injury, an individual's use of such personal protective eyewear may have deleterious effects on sensory information associated with information processing and postural control.

Oxidation and Emittance Studies of Coated Mo-Re

NASA Technical Reports Server (NTRS)

Glass, David E.

1997-01-01

A commercially available Fe-Cr-Si coating (R512E) and a silicide coating were evaluated regarding their ability to protect Mo-Re from oxidation. The R512E coating provided very good oxidation protection at 1260 C in atmospheric air. Oxidation tests were also performed at Mach 4 in the HYMETS facility at NASA Langley Research Center where again the R512E provided good oxidation protection but for much shorter times. Emittance measurements as a function of wavelength were also obtained for the R512E coating on Mo-Re after exposure to the Mach 4 environment at 1150 C and 1230 C.

Incorporation of Novel MRI and Biomarkers into Prostate Cancer Active Surveillance Risk Assessment

DTIC Science & Technology

2016-09-01

that are integral in the preparation for a career in clinical research. These goals are 1) training in T1 translational research; 2) training in the...Texas. In addition to basic mentoring tasks, we have identified four sources of mentorship in particular to my career , which include opportunities at...clinical schedule for protected time to ensure I meet the goals of my grant and career development. Research: We have successfully implemented

Economic efficiency of countries' clinical review processes and competitiveness on the market of human experimentation.

PubMed

Ippoliti, Roberto

2013-01-01

Clinical research is a specific phase of pharmaceutical industry's production process in which companies test candidate drugs on patients to collect clinical evidence about safety and effectiveness. Information is essential to obtain manufacturing authorization from the national drug agency and, in this way, make profits on the market. Considering this activity, however, the public stakeholder has to face a conflict of interests. On the one side, there is society's necessity to make advances in medicine and, of course, to promote pharmaceutical companies' investments in this specific phase (new generation). On the other side, there is the duty to protect patients involved in these experimental treatments (old generation). To abide by this moral duty, a protection system was developed through the years, based on two legal institutions: informed consent and institutional review board. How should an efficient protection system that would take human experimentation into account be shaped? Would it be possible for the national protection system of patients' rights to affect the choice of whether to develop a clinical trial in a given country or not? Looking at Europe and considering a protection system that is shaped around institutional review boards, this article is an empirical work that tries to give answers to these open questions. It shows how a protection system that can minimize the time necessary to start a trial can positively affect pharmaceutical clinical research, that is, the choice of pharmaceutical companies to start innovative medical treatments in a given country. Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

The intriguing evolution of effect sizes in biomedical research over time: smaller but more often statistically significant.

PubMed

Monsarrat, Paul; Vergnes, Jean-Noel

2018-01-01

In medicine, effect sizes (ESs) allow the effects of independent variables (including risk/protective factors or treatment interventions) on dependent variables (e.g., health outcomes) to be quantified. Given that many public health decisions and health care policies are based on ES estimates, it is important to assess how ESs are used in the biomedical literature and to investigate potential trends in their reporting over time. Through a big data approach, the text mining process automatically extracted 814 120 ESs from 13 322 754 PubMed abstracts. Eligible ESs were risk ratio, odds ratio, and hazard ratio, along with their confidence intervals. Here we show a remarkable decrease of ES values in PubMed abstracts between 1990 and 2015 while, concomitantly, results become more often statistically significant. Medians of ES values have decreased over time for both "risk" and "protective" values. This trend was found in nearly all fields of biomedical research, with the most marked downward tendency in genetics. Over the same period, the proportion of statistically significant ESs increased regularly: among the abstracts with at least 1 ES, 74% were statistically significant in 1990-1995, vs 85% in 2010-2015. whereas decreasing ESs could be an intrinsic evolution in biomedical research, the concomitant increase of statistically significant results is more intriguing. Although it is likely that growing sample sizes in biomedical research could explain these results, another explanation may lie in the "publish or perish" context of scientific research, with the probability of a growing orientation toward sensationalism in research reports. Important provisions must be made to improve the credibility of biomedical research and limit waste of resources. © The Authors 2017. Published by Oxford University Press.

Implications of the 21st Century Cures Act for the Behavioral and Social Sciences at the National Institutes of Health

ERIC Educational Resources Information Center

Riley, William T.; Blizinsky, Katherine D.

2017-01-01

The 21st Century Cures Act provides funding for key initiatives relevant to the behavioral and social sciences and includes administrative provisions that facilitate health research and increase the privacy protections of research participants. At about the same time as the passage of the Act, the National Institutes of Health Office of Behavioral…

Military Vision Research Program

DTIC Science & Technology

2012-10-01

LASIK ) and photorefractive keratectomy ( PRK ). Perturbation of mucin secreting cells in the conjunctiva results in compromised protection conferred by the...KEY RESEARCH ACCOMPLISHMENTS: • Association of TSP-1 SNP with development of dry eye after LASIK or PRK REPORTABLE OUTCOMES: Manuscript (under...that the suppression of endomucin by arterial shear stress is mediated by KLF2. Real-time PCR analysis of EMCN-1 expression in Ad-Ctrl vs . Ad-KLF2

Immune correlates of protection for dengue: State of the art and research agenda.

PubMed

Katzelnick, Leah C; Harris, Eva

2017-08-24

Dengue viruses (DENV1-4) are mosquito-borne flaviviruses estimated to cause up to ∼400 million infections and ∼100 million dengue cases each year. Factors that contribute to protection from and risk of dengue and severe dengue disease have been studied extensively but are still not fully understood. Results from Phase 3 vaccine efficacy trials have recently become available for one vaccine candidate, now licensed for use in several countries, and more Phase 2 and 3 studies of additional vaccine candidates are ongoing, making these issues all the more urgent and timely. At the "Summit on Dengue Immune Correlates of Protection", held in Annecy, France, on March 8-9, 2016, dengue experts from diverse fields came together to discuss the current understanding of the immune response to and protection from DENV infection and disease, identify key unanswered questions, discuss data on immune correlates and plans for comparison of results across assays/consortia, and propose a research agenda for investigation of dengue immune correlates, all in the context of both natural infection studies and vaccine trials. Copyright © 2017.

Rock Island Arsenal Power Dam: Numerical Hydraulic Model Investigation of Channel Capacity for Power Generation

DTIC Science & Technology

2016-06-01

Coastal Storm Protection . The Director of ERDC-CHL was José E. Sánchez. At the time of publication of this report, COL Bryan S. Green was the...Marielys Ramos-Villanueva, and Ronald E. Heath Coastal and Hydraulics Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry...behavior. The work was performed by the River Engineering Branch (CEERD-HFR) of the Flood and Storm Protection Division (CEERD-HF), U.S. Army

Remembrances of Ulf Svante von Euler.

PubMed

Igić, Rajko

2018-05-21

I first met Ulf Svante von Euler when he came to Belgrade, in 1968, to attend an international symposium on the occasion of the 50 th anniversary of the Medical Faculty. I was at that time a graduate student at the Medical Faculty in Sarajevo, and a new researcher. I had finished medical school in Belgrade and had worked for two years as a physician in the northern part of Serbia. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Longitudinal Associations Among Religiousness, Delay Discounting, and Substance Use Initiation in Early Adolescence

PubMed Central

Kim-Spoon, Jungmeen; McCullough, Michael E.; Bickel, W. K.; Farley, Julee P.; Longo, Gregory S.

2014-01-01

Prior research indicates that religiousness is related negatively to adolescent health risk behaviors, yet how such protective effects operate is not well understood. This study examined the longitudinal associations among organizational and personal religiousness, delay discounting, and substance use initiation (alcohol, cigarette, and marijuana use). The sample comprised 106 early adolescents (10-13 years of age, 52% female) who were not using substances at Time 1. Path analyses suggested that high levels of personal religiousness at Time 1 were related to low levels of substance use at Time 2 (2.4 years later), mediated by low levels of delay discounting. Delay discounting appears to be an important contributor to the protective effect of religiousness on the development of substance use among adolescents. PMID:25750491

77 FR 55215 - Solicitation of Nominations for Membership on the Secretary's Advisory Committee on Human...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... toward protections for human subjects in research. Specifically, the Committee provides advice relating... Secretary's Advisory Committee on Human Research Protections AGENCY: Office for Human Research Protections... Human Research Protections (OHRP), a program office in the Office of the Assistant Secretary for Health...

75 FR 71443 - Renewal of Charter for the Secretary's Advisory Committee on Human Research Protections

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... on Human Research Protections AGENCY: Department of Health and Human Services, Office of the... Research Protections (SACHRP). FOR FURTHER INFORMATION CONTACT: Jerry Menikoff, M.D., J.D., Director, Office for Human Research Protections or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department...

40 CFR 26.405 - Observational research involving greater than minimal risk but presenting the prospect of direct...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Observational research involving... Section 26.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Observational Research: Additional Protections for Children Involved as Subjects in Observational...

Religion and Substance Use among Youths of Mexican Heritage: A Social Capital Perspective

PubMed Central

Hodge, David R.; Marsiglia, Flavio F.; Nieri, Tanya

2011-01-01

Despite elevated levels of substance use among many Latino youths, there has been little research on protective factors against such use. In keeping with federal commitments to address health disparities, this prospective study examined the protective influence of religion on substance use among a school-based sample (N = 804) of youths of Mexican heritage in the American Southwest. Drawing from the social capital literature, the authors posited that both integration into religious networks and trust in religious values at time 1 (Tl) would predict less likelihood of using substances at time 2 (T2) but that exposure to religious norms at Tl would not predict subsequent substance use at T2. The hypotheses regarding religious networks and religious norms were largely confirmed, whereas little support emerged for the hypothesis regarding religious values. The results are discussed in light of the various pathways through which religion may exhibit a protective influence. PMID:22140302

Systematic review: association of shift length, protected sleep time, and night float with patient care, residents' health, and education.

PubMed

Reed, Darcy A; Fletcher, Kathlyn E; Arora, Vineet M

2010-12-21

The Accreditation Council for Graduate Medical Education's new duty-hour standards limit interns' shifts to 16 hours and night float to 6 consecutive nights. Protected sleep time (that is, "nap") is strongly encouraged. As duty-hour reforms are implemented, examination of the quality and outcomes of the relevant literature is important. To systematically review the literature examining shift length, protected sleep time, and night float. MEDLINE, PREMEDLINE, and EMBASE from January 1989 through May 2010. Studies examined the associations of shift length, protected sleep time, or night float with patient care, resident health, and education outcomes among residents in practice settings. Study quality was measured by using the validated Medical Education Research Study Quality Instrument and the U.S. Preventive Services Task Force criteria. Two investigators independently rated study quality, and interrater agreement was calculated. Sixty-four studies met inclusion criteria. Most studies used single-group cross-sectional (19 studies [29.7%]) or pre-post (41 studies [64.1%]) designs, and 4 (6.3%) were randomized, controlled trials. Five studies (7.8%) were multi-institutional. Twenty-four of 33 (72.7%) studies examining shift length reported that shorter shifts were associated with decreased medical errors, motor vehicle crashes, and percutaneous injuries. Only 2 studies assessed protected sleep time and reported that residents' adherence to naps was poor. Night floats described in 33 studies involved 5 to 7 consecutive nights. Most studies used single-institution, observational designs. Publication bias is likely but difficult to assess in this methodologically weak and heterogeneous body of evidence. For the limited outcomes measured, most studies supported reducing shift length but did not adequately address the optimal shift duration. Studies had numerous methodological limitations and unclear generalizability for most outcomes. Specific recommendations about shift length, protected sleep time, and night float should acknowledge the limitations of this evidence. Accreditation Council for Graduate Medical Education.

Unconventional High-Performance Laser Protection System Based on Dichroic Dye-Doped Cholesteric Liquid Crystals

NASA Astrophysics Data System (ADS)

Zhang, Wanshu; Zhang, Lanying; Liang, Xiao; Le Zhou; Xiao, Jiumei; Yu, Li; Li, Fasheng; Cao, Hui; Li, Kexuan; Yang, Zhou; Yang, Huai

2017-02-01

High-performance and cost-effective laser protection system is of crucial importance for the rapid advance of lasers in military and civilian fields leading to severe damages of human eyes and sensitive optical devices. However, it is crucially hindered by the angle-dependent protective effect and the complex preparation process. Here we demonstrate that angle-independence, good processibility, wavelength tunability, high optical density and good visibility can be effectuated simultaneously, by embedding dichroic anthraquinone dyes in a cholesteric liquid crystal matrix. More significantly, unconventional two-dimensional parabolic protection behavior is reported for the first time that in stark contrast to the existing protection systems, the overall parabolic protection behavior enables protective effect to increase with incident angles, hence providing omnibearing high-performance protection. The protective effect is controllable by dye concentration, LC cell thickness and CLC reflection efficiency, and the system can be made flexible enabling applications in flexible and even wearable protection devices. This research creates a promising avenue for the high-performance and cost-effective laser protection, and may foster the development of optical applications such as solar concentrators, car explosion-proof membrane, smart windows and polarizers.

MODELING AND MEASUREMENT OF REAL-TIME CO CONCENTRATIONS IN ROADWAY MICROENVIRONMENTS

EPA Science Inventory

Although emission standards for motor vehicles continue to be tightened, tailpipe emissions continue to be a major source of human exposure to air toxics. The United States Environmental protection Agency's national Exposure Research laboratory has initiated a project to impro...

42 CFR 84.52 - Respiratory hazards; classification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

42 CFR 84.52 - Respiratory hazards; classification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

42 CFR 84.52 - Respiratory hazards; classification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

42 CFR 84.52 - Respiratory hazards; classification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

42 CFR 84.52 - Respiratory hazards; classification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

Moral Duties of Genomics Researchers: Why Personalized Medicine Requires a Collective Approach.

PubMed

Vos, Shoko; van Delden, Johannes J M; van Diest, Paul J; Bredenoord, Annelien L

2017-02-01

Advances in genome sequencing together with the introduction of personalized medicine offer promising new avenues for research and precision treatment, particularly in the field of oncology. At the same time, the convergence of genomics, bioinformatics, and the collection of human tissues and patient data creates novel moral duties for researchers. After all, unprecedented amounts of potentially sensitive information are being generated. Over time, traditional research ethics principles aimed at protecting individual participants have become supplemented with social obligations related to the interests of society and the research enterprise at large, illustrating that genomic medicine is also a social endeavor. In this review we provide a comprehensive assembly of moral duties that have been attributed to genomics researchers and offer suggestions for responsible advancement of personalized genomic cancer care. Copyright © 2016 Elsevier Ltd. All rights reserved.

Wood Protection Research Council: Research Priorities 2013

Treesearch

Carol A Clausen; Frederick Green III; Grant T. Kirker; Stan T. Lebow

2014-01-01

This report summarizes presentations and comments from the inaugural Wood Protection Research Council meeting. Research needs for the wood protection industry were identified and prioritized. Methods for successfully addressing research needs were discussed by industry, academia, and association representatives.

Sun Protection Preferences and Behaviors among Young Adult Males during Maximum Ultraviolet Radiation Exposure Activities

PubMed Central

Wickenheiser, Marilyn; Baker, Mary Kate; Gaber, Rikki; Blatt, Hanz; Robinson, June K.

2013-01-01

This study explores sun protection attitudes, preferences, and behaviors among young adult males participating in an open-field activity with extreme ultraviolet radiation exposure. Male drum corps members (n = 137) responded to survey questions regarding their behavior and willingness to engage in sun protection and barriers to sunscreen usage. A subset of members (n = 31) participated in cognitive interviews exploring various sunscreen products and intervention techniques. Participants were knowledgeable about health risks and protection benefits regarding sun exposure. Generally, males had positive attitudes and normative beliefs about using sunscreen. A barrier to sunscreen re-application was lack of adequate time to reapply sunscreen during the open field activity. Males preferred a towelette application method, but were unfamiliar with its efficacy and proper use. Thus, they were more likely to use the more familiar sunscreen spray. To increase sun protection behaviors and lower skin cancer risk for males participating in open-field activities, breaks must be allotted every 2 h and have sufficient time to allow sunscreen application. Future development and research into delivery systems that rapidly and evenly apply sunscreen may help lower exposure in this population. PMID:23912201

Protective orders: questions and conundrums.

PubMed

Logan, T K; Shannon, Lisa; Walker, Robert; Faragher, Teri Marie

2006-07-01

Current media portrayal of protective orders is often negative, focusing on weaknesses in how protective orders are obtained and enforced. This review of research findings on protective orders examines issues and suggests areas in need of future research to clarify and improve public policy. More specifically, this review has five main objectives: (a) to provide background information about partner violence and the need for protective orders; (b) to describe what protective orders are, how many women obtain them, and the advantages and disadvantages of obtaining protective orders; (c) to examine characteristics of women who seek protective orders; (d) to explore research on whether protective orders actually increase women's safety; and (e) to highlight opportunities and gaps in the practice and research literature regarding the use of protective orders for women with violent partners or ex-partners.

The acceptability of conducting data linkage research without obtaining consent: lay people's views and justifications.

PubMed

Xafis, Vicki

2015-11-17

A key ethical issue arising in data linkage research relates to consent requirements. Patients' consent preferences in the context of health research have been explored but their consent preferences regarding data linkage specifically have been under-explored. In addition, the views on data linkage are often those of patient groups. As a result, little is known about lay people's views and their preferences about consent requirements in the context of data linkage. This study explores lay people's views and justifications regarding the acceptability of conducting data linkage research without obtaining consent. A qualitative study explored lay people's views regarding consent requirements in data linkage via four hypothetical data linkage scenarios of increasing complexity. Prior to considering the scenarios, participants were provided with information regarding best practice data linkage processes via discussion and a diagrammatic representation of the process. Lay people were able to understand the intricate processes involved in data linkage and the key protections afforded within a short amount of time. They were supportive of data linkage research and, on the whole, believed it should be conducted without consent provided a data linkage organization de-identifies the data used so that researchers do not handle identifiable data. Many thought that de-identified data holds a different status to identifiable data and should be used without specific consent in research that aims to benefit society. In weighing up conflicting values and interests, participants shifted consent preferences before arriving at their final consent preference for each scenario and provided justifications for their choices. They considered the protection of people's information, societal benefits, and the nature and constraints of research and recognized that these need to be balanced. With some exposure to the features of data linkage, lay people have the capacity to understand the processes sufficiently in order to consider ethical issues associated with consent preferences. Shifts in views reveal the complexity of such decisions. While privacy protection remained an important consideration for most participants, adequate protection measures adopted in best practice data linkage were viewed by most as protection enough for data linkage to proceed without specific individual consent.

Securing Real-Time Sessions in an IMS-Based Architecture

NASA Astrophysics Data System (ADS)

Cennamo, Paolo; Fresa, Antonio; Longo, Maurizio; Postiglione, Fabio; Robustelli, Anton Luca; Toro, Francesco

The emerging all-IP mobile network infrastructures based on 3rd Generation IP Multimedia Subsystem philosophy are characterised by radio access technology independence and ubiquitous connectivity for mobile users. Currently, great focus is being devoted to security issues since most of the security threats presently affecting the public Internet domain, and the upcoming ones as well, are going to be suffered by mobile users in the years to come. While a great deal of research activity, together with standardisation efforts and experimentations, is carried out on mechanisms for signalling protection, very few integrated frameworks for real-time multimedia data protection have been proposed in a context of IP Multimedia Subsystem, and even fewer experimental results based on testbeds are available. In this paper, after a general overview of the security issues arising in an advanced IP Multimedia Subsystem scenario, a comprehensive infrastructure for real-time multimedia data protection, based on the adoption of the Secure Real-Time Protocol, is proposed; then, the development of a testbed incorporating such functionalities, including mechanisms for key management and cryptographic context transfer, and allowing the setup of Secure Real-Time Protocol sessions is presented; finally, experimental results are provided together with quantitative assessments and comparisons of system performances for audio sessions with and without the adoption of the Secure Real-Time Protocol framework.

34 CFR 75.681 - Protection of human research subjects.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Protection of human research subjects. 75.681 Section... Conditions Must Be Met by a Grantee? Other Requirements for Certain Projects § 75.681 Protection of human research subjects. If a grantee uses a human subject in a research project, the grantee shall protect the...

34 CFR 75.681 - Protection of human research subjects.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Protection of human research subjects. 75.681 Section... Conditions Must Be Met by a Grantee? Other Requirements for Certain Projects § 75.681 Protection of human research subjects. If a grantee uses a human subject in a research project, the grantee shall protect the...

34 CFR 75.681 - Protection of human research subjects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Protection of human research subjects. 75.681 Section... Conditions Must Be Met by a Grantee? Other Requirements for Certain Projects § 75.681 Protection of human research subjects. If a grantee uses a human subject in a research project, the grantee shall protect the...

34 CFR 75.681 - Protection of human research subjects.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false Protection of human research subjects. 75.681 Section... Conditions Must Be Met by a Grantee? Other Requirements for Certain Projects § 75.681 Protection of human research subjects. If a grantee uses a human subject in a research project, the grantee shall protect the...

40 CFR 26.113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... approval of research. 26.113 Section 26.113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.113 Suspension or termination of IRB approval of research. An IRB shall...

40 CFR 26.113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... approval of research. 26.113 Section 26.113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.113 Suspension or termination of IRB approval of research. An IRB shall...

34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... the protection of the rights and welfare of human subjects (whether or not the research was subject to...

Costs and inconsistencies in US IRB review of low-risk medical education research.

PubMed

Kano, Miria; Getrich, Christina M; Romney, Crystal; Sussman, Andrew L; Williams, Robert L

2015-06-01

Advances in communication technologies over the last two decades have transformed the way medical education research is conducted, creating opportunities for multi-institution national and international studies. Although these studies enable researchers to gain broader understandings of educational processes across institutions, they increase the need for multiple institutional review board (IRB) reviews to ensure the protection of human subjects. This study describes the process of obtaining multiple IRB approvals of the same protocol for a multi-site, low-risk, medical education research project in the USA. The burden of obtaining those reviews and their consistency are assessed. The associated time and costs, and implications for the research process are detailed. Following review by the investigators' parent institution IRB, the project team circulated a uniform protocol for conduct of a low-risk, medical education survey to the IRBs of 89 US medical schools for review. The processes and time required to obtain approvals were recorded to estimate associated research team personnel costs. Approval could not be obtained from five IRBs as a result of insurmountable procedural barriers. A total of 67 IRBs eventually deferred to the parent IRB determination. The remaining IRBs required a variety of additional procedural processes before ultimately agreeing with the original determination. The personnel costs associated with obtaining the 84 approvals amounted to US$121,344. Considering the value of multi-site designs to address a range of research questions, enhance participant diversity and develop representative findings, solutions must be found to counter inefficiencies of current IRB review processes for low-risk research, such as that usually conducted in medical education. Although we acknowledge that local review is an essential protective measure for research involving identifiable communities that are uniquely susceptible to social or economic harm, this report suggests that proposals to modernise and streamline IRB review processes for low-risk research are timely and relevant. © 2015 John Wiley & Sons Ltd.

Limited privacy protection and poor sensitivity: Is it time to move on from the statistical linkage key-581?

PubMed

Randall, Sean M; Ferrante, Anna M; Boyd, James H; Brown, Adrian P; Semmens, James B

2016-08-01

The statistical linkage key (SLK-581) is a common tool for record linkage in Australia, due to its ability to provide some privacy protection. However, newer privacy-preserving approaches may provide greater privacy protection, while allowing high-quality linkage. To evaluate the standard SLK-581, encrypted SLK-581 and a newer privacy-preserving approach using Bloom filters, in terms of both privacy and linkage quality. Linkage quality was compared by conducting linkages on Australian health datasets using these three techniques and examining results. Privacy was compared qualitatively in relation to a series of scenarios where privacy breaches may occur. The Bloom filter technique offered greater privacy protection and linkage quality compared to the SLK-based method commonly used in Australia. The adoption of new privacy-preserving methods would allow both greater confidence in research results, while significantly improving privacy protection. © The Author(s) 2016.

Radon Exposure and the Definition of Low Doses-The Problem of Spatial Dose Distribution.

PubMed

Madas, Balázs G

2016-07-01

Investigating the health effects of low doses of ionizing radiation is considered to be one of the most important fields in radiological protection research. Although the definition of low dose given by a dose range seems to be clear, it leaves some open questions. For example, the time frame and the target volume in which absorbed dose is measured have to be defined. While dose rate is considered in the current system of radiological protection, the same cancer risk is associated with all exposures, resulting in a given amount of energy absorbed by a single target cell or distributed among all the target cells of a given organ. However, the biological effects and so the health consequences of these extreme exposure scenarios are unlikely to be the same. Due to the heterogeneous deposition of radon progeny within the lungs, heterogeneous radiation exposure becomes a practical issue in radiological protection. While the macroscopic dose is still within the low dose range, local tissue doses on the order of Grays can be reached in the most exposed parts of the bronchial airways. It can be concluded that progress in low dose research needs not only low dose but also high dose experiments where small parts of a biological sample receive doses on the order of Grays, while the average dose over the whole sample remains low. A narrow interpretation of low dose research might exclude investigations with high relevance to radiological protection. Therefore, studies important to radiological protection should be performed in the frame of low dose research even if the applied doses do not fit in the dose range used for the definition of low doses.

Working Mothers, Breastfeeding, and the Law

PubMed Central

Moulton, Anthony D.

2011-01-01

Workplace barriers contribute to low rates of breastfeeding. Research shows that supportive state laws correlate with higher rates, yet by 2009, only 23 states had adopted any laws to encourage breastfeeding in the workplace. Federal law provided virtually no protection to working mothers until the 2010 enactment of the “reasonable break time” provision of the Patient Protection and Affordable Care Act. This provision nonetheless leaves many working mothers uncovered, requires break time only to pump for (not feed) children younger than 1 year, and exempts small employers that demonstrate hardship. Public health professionals should explore ways to improve legal support for all working mothers wishing to breastfeed. Researchers should identify the laws that are most effective and assist policymakers in translating them into policy. PMID:21164100

42 CFR 93.401 - Interaction with other offices and interim actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

42 CFR 93.401 - Interaction with other offices and interim actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

42 CFR 93.401 - Interaction with other offices and interim actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

42 CFR 93.401 - Interaction with other offices and interim actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners.

PubMed

Siriwardena, Aloysius Niroshan; Middlemass, Jo B; Ward, Kate; Wilkinson, Carol

2008-01-19

A number of protected learning time schemes have been set up in primary care across the United Kingdom but there has been little published evidence of their impact on processes of care. We undertook a qualitative study to investigate the perceptions of practitioners involved in a specific educational intervention in diabetes as part of a protected learning time scheme for primary health care teams, relating to changing processes of diabetes care in general practice. We undertook semistructured interviews of key informants from a sample of practices stratified according to the extent they had changed behaviour in prescribing of ramipril and diabetes care more generally, following a specific educational intervention in Lincolnshire, United Kingdom. Interviews sought information on facilitators and barriers to change in organisational behaviour for the care of diabetes. An interprofessional protected learning time scheme event was perceived by some but not all participants as bringing about changes in processes for diabetes care. Participants cited examples of change introduced partly as a result of the educational session. This included using ACE inhibitors as first line for patients with diabetes who developed hypertension, increased use of aspirin, switching patients to glitazones, and conversion to insulin either directly or by referral to secondary care. Other reported factors for change, unrelated to the educational intervention, included financially driven performance targets, research evidence and national guidance. Facilitators for change linked to the educational session were peer support and teamworking supported by audit and comparative feedback. This study has shown how a protected learning time scheme, using interprofessional learning, local opinion leaders and early implementers as change agents may have influenced changes in systems of diabetes care in selected practices but also how other confounding factors played an important part in changes that occurred in practice.

The psychosocial impact of armed conflict on children. Rethinking traditional paradigms in research and intervention.

PubMed

Stichick, T

2001-10-01

It is undeniable that the impact of war on children is a significant issue that merits continued efforts in research and intervention. It is time for a shift in paradigms; instead of focusing solely on exposure to traumatic events and defining pathology per dominant diagnostic criteria, it is essential that research turn to examining the effect of chronic stressors and exploring how certain mechanisms may be protective or act to moderate the psychosocial impact of war on children. The role of such protective mechanisms must be examined for differences by development and gender and by cultural context and the nature of the conflict situation itself. Investigations of the health and psychosocial well-being of war-affected children and the programs that serve them must attend to the restoration of basic physiologic needs, safety, structure, familial ties, and other sources of support and integration of cultural practices of healing. The coping efforts of young people and their families and the creation of more positive roles for youth also must be explored. Addressing these fundamental issues in research and programming will go a long way in fostering new opportunities for peace, healing, and the promotion of mental health and well-being for war-affected children in modern times.

Resilience and protective factors among people with a history of child maltreatment: a systematic review.

PubMed

Meng, Xiangfei; Fleury, Marie-Josee; Xiang, Yu-Tao; Li, Muzi; D'Arcy, Carl

2018-05-01

To provide an overview of resilience and protective factors associated with a better life following child maltreatment exposure, to compare protective factors across specific subtypes of maltreatment, and to explore existing issues in the current state of the literature. Electronic databases and grey literature up to October 2017 were systematically searched for English language with observational study designs for the research on resilience and childhood maltreatment. Systematic review and qualitative approaches were used to synthesize the results. Study quality and heterogeneity were also examined. Initial screening of titles and abstracts resulted in 247 papers being reviewed. A total of 85 articles met eligibility criteria of this review. Most of these studies had low or middle study quality. There were two subgroups of studies reviewed: (1) 11 studies examined whether resilience protected against the negative consequence of childhood maltreatment, and, (2) 75 studies explored what protective factor was associated with a kind of adaptive functioning. Although the conceptualization of resilience significantly varied from study to study, protective factors associated with resilience at individual, familial, and societal levels reduced the likelihood of negative consequences of childhood maltreatment. Negative consequences following childhood maltreatment can be prevented or moderated if protective factors are provided in time. Future research needs to address the conceptualization issue of resilience. Public and population mental health preventions should focus on early childhood and apply preventive strategies as early as possible. Cost-effective studies should be considered in the evaluation of resilience prevention program.

Improving capacity for evidence-based practice in South East Asia: evaluating the role of research fellowships in the SEA-ORCHID Project

PubMed Central

2010-01-01

Background Fellowships are a component of many professional education programs. They provide opportunities to develop skills and competencies in an environment where time is protected and resources and technical support are more readily available. The SEA-ORCHID fellowships program aimed to increase capacity for evidence-based practice and research synthesis, and to encourage fellows to become leaders in these areas. Methods Fellows included doctors, nurses, midwives and librarians working in the maternal and neonatal areas of nine hospitals in South East Asia. Fellowships were undertaken in Australia and involved specific outputs related to evidence-based practice or research synthesis. Training and support was tailored according to the type of output and the fellow's experience and expertise. We evaluated the fellowships program quantitatively and qualitatively through written evaluations, interviews and follow-up of fellowship activities. Results During 2006-07, 23 fellows from Thailand, Indonesia, Malaysia and the Philippines undertook short-term fellowships (median four weeks) in Australia. The main outputs were drafts of Cochrane systematic reviews, clinical practice guidelines and protocols for randomised trials, and training materials to support evidence-based practice. Protocols for Cochrane systematic reviews were more likely to be completed than other outcomes. The fellows identified several components that were critical to the program's overall success; these included protected time, tailored training, and access to technical expertise and resources. On returning home, fellows identified a lack of time and limited access to the internet and evidence-based resources as barriers to completing their outputs. The support of colleagues and senior staff was noted as an important enabler of progress, and research collaborators from other institutions and countries were also important sources of support. Conclusions The SEA-ORCHID fellowships program provided protected time to work on an output which would facilitate evidence-based practice. While the fellows faced substantial barriers to completing their fellowship outputs once they returned home, these fellowships resulted in a greater understanding, enthusiasm and skills for evidence-based practice. The experience of the SEA-ORCHID fellowships program may be useful for other initiatives aiming to build capacity in evidence-based practice. PMID:20492706

Theoretical Risk and Prevention Model for Secondary Health Conditions and Mortality After SCI: 15 Years of Research

PubMed Central

Krause, James S.; Saunders, Lee L.; DiPiro, Nicole D.; Reed, Karla S.

2013-01-01

Background: To successfully prevent secondary health conditions (SHCs) and promote longevity after spinal cord injury (SCI), we must first understand the risk factors precipitating their occurrence and develop strategies to address these risk factors. Conceptual models may aid in identifying the nature of SHCs and guide research, clinical practice, and the development of prevention strategies. Objective: Our purpose is to review and refine an existing theoretical risk and prevention model (TRPM) as a means of classifying risk and protective factors for SHCs and mortality after SCI and for identifying points of intervention. Methods: We describe conceptual work within the field of SCI research and SHCs, including a description of the TRPM, a review of research using the TRPM, and conceptual enhancements to the TRPM based on previous research. Conclusions: The enhanced TRPM directs research to the timing and chronicity of the SHCs and their relationship with overall health and physiologic decline. Future research should identify differences in the nature of SHCs, the extent to which they relate to risk and protective factors, and the degree to which they may be prevented with appropriate research-based strategies. PMID:23459002

Online gambling's moderators: how effective? Study protocol for a randomized controlled trial.

PubMed

Caillon, Julie; Grall-Bronnec, Marie; Hardouin, Jean-Benoit; Venisse, Jean-Luc; Challet-Bouju, Gaelle

2015-05-30

Online gambling has been legalized in France in 2010. Licenses are issued to gambling operators who demonstrate their ability to respect the legal framework (security, taxation, consumer protection, etc.). The preventive measures to protect vulnerable gamblers include an obligation to provide online gambling moderators. These moderators should allow gamblers to limit their bets, exclude themselves from the website for 7 days, and consult the balance of the gambler's account at any time. However, there are only a few published reports of empirical research investigating the effectiveness of Internet-based protective measures implemented by French law. Moreover, no empirical research has yet studied the impact of bonuses on gambling behaviors. This research is an experimental randomized controlled trial, risk prevention targeted. The research is divided into four sub-studies depending on the studied moderator: limiting bonuses, self-exclusion, self-limitation and information. The study sample consists of 485 volunteers. For each experimental condition and the control groups, the sample is composed of gamblers equally recruited from gamblers having preferences in each of the three major forms of games (lottery and scratch tickets, sports and horserace betting, and poker). For each form of gambling, the gamblers are recruited in order to obtain as many problem gamblers as non-problem gamblers. According to the randomization, the experimental session begins. The experimental session is a gambling situation on a computer in our research center. The gambler is invited to play on his favorite gambling site as usual, with his own gambler account and his own money. Data collected comprise sociodemographic characteristics, gambling habits, an interview about enjoyment and feeling out of control during the gambling session, moderator impact on gambling practice, statement of gambling parameters and questionnaires (BMIS, GRCS, CPGI, GACS). Moderator efficiency is assessed based on the two major characteristics of gambling behavior: money wagered and time spent in gambling. The results of this research will be important to prevent online problem gambling and influence policy-makers. NCT01789580. Registered 8 February 2013.

40 CFR 26.1123 - Early termination of research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Early termination of research. 26.1123 Section 26.1123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1123 - Early termination of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Early termination of research. 26.1123 Section 26.1123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1109 - IRB review of research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false IRB review of research. 26.1109 Section 26.1109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1109 - IRB review of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false IRB review of research. 26.1109 Section 26.1109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1109 - IRB review of research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false IRB review of research. 26.1109 Section 26.1109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1123 - Early termination of research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Early termination of research. 26.1123 Section 26.1123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1123 - Early termination of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Early termination of research. 26.1123 Section 26.1123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1123 - Early termination of research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Early termination of research. 26.1123 Section 26.1123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1109 - IRB review of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false IRB review of research. 26.1109 Section 26.1109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

40 CFR 26.1109 - IRB review of research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false IRB review of research. 26.1109 Section 26.1109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional...

Social dominance, school bullying, and child health: what are our ethical obligations to the very young?

PubMed

Halpern, Jodi; Jutte, Douglas; Colby, Jackie; Boyce, W Thomas

2015-03-01

Recent research shows that by age 5, children form rigid social hierarchies, with some children consistently subordinated, and then later, bullied. Further, several studies suggest that enduring mental and physical harm follow. It is time to analyze the health burdens posed by early social dominance and to consider the ethical implications of ongoing socially caused harms. First, we reviewed research demonstrating the health impact of early childhood subordination. Second, we used philosophical conceptions of children's rights and social justice to consider whether children have a right to protection and who has an obligation to protect them from social harms. Collectively, recent studies show that early subordination is instantiated biologically, increasing lifetime physical and mental health problems. The pervasive, and enduring nature of these harms leads us to argue that children have a right to be protected. Further, society has a role responsibility to protect children because society conscripts children into schools. Society's promise to parents that schools will be fiduciaries entails an obligation to safeguard each child's right to a reasonably open future. Importantly, this role responsibility holds independently of bearing any causal responsibility for the harm. This new argument based on protecting from harm is much stronger than previous equality of opportunity arguments, and applies broadly to other social determinants of health. Social institutions have a role responsibility to protect children that is not dependent on playing a causal role in the harm. Children's rights to protection from social harms can be as strong as their rights to protection from direct bodily harms. Copyright © 2015 by the American Academy of Pediatrics.

40 CFR 2.309 - Special rules governing certain information obtained under the Marine Protection, Research and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... information obtained under the Marine Protection, Research and Sanctuaries Act of 1972. 2.309 Section 2.309... Protection, Research and Sanctuaries Act of 1972. (a) Definitions. For the purposes of this section: (1) Act means the Marine Protection, Research and Sanctuaries Act of 1972, 33 U.S.C. 1401 et seq. (2) Permit...

Evaluation of sensors for use inside chemical protective suits

NASA Astrophysics Data System (ADS)

Russell, Derrick A.; Duncan, E. J. S.; Hunt, Stephen; Gudgin Dickson, Eva F.; Weagle, Glenn E.

1999-11-01

Organizations such as the military, hazardous materials units, first responders and industries involved in the processing and manufacture of chemicals all have requirements for specialized whole body protection for those people in their organizations whose job it is to work with toxic chemicals on a day to day basis or in emergency situations. Currently, excluding chemical biological (CB) challenge scenarios, there is no routine monitoring of the possible ingress of toxic chemicals within chemical protective suits. Under existing national standards, swatches of the protective suit fabric are usually tested for chemical breakthrough and if they meet certain criteria, the suit is considered to provide adequate protection to the individual. Despite advances in protection level research provided by full system protective clothing tests, inexpensive, real-time, sensitive and robust chemical monitoring systems for use both under protective clothing and within a challenge environment, remains a technologically deficient area. This paper presents the results of a preliminary assessment of the feasibility of miniature detectors for monitoring real-time volatile organic chemical (VOC) challenges under chemical protective clothing and in closed environments where such suits are used. Nine gas sensors of n-type semiconductor design (Figaro Engineering Inc) were assessed for their response to a dichloromethane concentration of 560 ppm at a temperature of 23 degrees Celsius and relative humidity of 20%. Absolute voltage output, speed of response to dichloromethane exposure, and time required to return to zero, were considered. The top ranked sensor was further evaluated for its calibration response to a range of dichloromethane concentrations up to 560 ppm. Variables that were considered include effect of temperature and relative humidity, hysteresis and repeatability. Increasing RH causes an increase in the zero output of the sensor with an approximate linear relationship. The sensor response was characterized by minimal hysteresis, indicating that calibration values over the short term are very stable. Calibration responses measured on different days were in excellent agreement.

40 CFR 26.1111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Criteria for IRB approval of research. 26.1111 Section 26.1111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving...

40 CFR 26.1111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Criteria for IRB approval of research. 26.1111 Section 26.1111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving...

40 CFR 26.1111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Criteria for IRB approval of research. 26.1111 Section 26.1111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving...

40 CFR 26.1111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Criteria for IRB approval of research. 26.1111 Section 26.1111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving...

78 FR 24152 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

..., Office of Management and Budget (OMB), [email protected] or fax (202) 395-5806 and to... Establishment Innovation Survey (REIS). OMB Control Number: 0536-NEW. Summary of Collection: The Economic Research Service (ERS) plans to conduct the Rural Establishment Innovation Survey (REIS) as a one-time...

48 CFR 3452.227-72 - Use and Non-Disclosure Agreement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... marked with Small Business Innovative Research (SBIR) data rights legends only for government purposes... example, enhance, decompile, disassemble, or reverse engineer the software; time share; or use a computer... designed to protect these data from inadvertent release or disclosure to unauthorized third parties. (3...

48 CFR 3452.227-72 - Use and Non-Disclosure Agreement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... marked with Small Business Innovative Research (SBIR) data rights legends only for government purposes... example, enhance, decompile, disassemble, or reverse engineer the software; time share; or use a computer... designed to protect these data from inadvertent release or disclosure to unauthorized third parties. (3...

48 CFR 3452.227-72 - Use and Non-Disclosure Agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... marked with Small Business Innovative Research (SBIR) data rights legends only for government purposes... example, enhance, decompile, disassemble, or reverse engineer the software; time share; or use a computer... designed to protect these data from inadvertent release or disclosure to unauthorized third parties. (3...

48 CFR 3452.227-72 - Use and Non-Disclosure Agreement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... marked with Small Business Innovative Research (SBIR) data rights legends only for government purposes... example, enhance, decompile, disassemble, or reverse engineer the software; time share; or use a computer... designed to protect these data from inadvertent release or disclosure to unauthorized third parties. (3...

OZONE AND NATURAL SYSTEMS: UNDERSTANDING EXPOSURE, RESPONSE, AND RISK

EPA Science Inventory

Research aimed at understanding the response of plants to ozone has been conducted for over four decades but little of it has addressed intact natural systems. Even so, there is sufficient information at this time to establish air quality standards that will protect natural terr...

DEVELOPMENT OF A MICROSCALE EMISSION FACTOR MODEL FOR CO FOR PREDICTING REAL-TIME MOTOR VEHICLE EMISSIONS

EPA Science Inventory

The United States Environmental Protection Agency's (EPA) National Exposure Research Laboratory (NERL) has initiated a project to improve the methodology for modeling human exposure to motor vehicle emission. The overall project goal is to develop improved methods for modeling...

Regenerating Longleaf Pine Naturally

Treesearch

Thomas C. Croker; William D. Boyer

1975-01-01

Research has developed guides for consistent natural regeneration of longleaf pine by a shelterwood system. Key measures include hardwood control by fire and other means, timely preparatory and seed cuts, seed crop monitoring, seedbed preparation, protection of established seedlings, prompt removal of parent trees when reproduction is adequate, and control of...

Parenting and Cyberbullying Across Adolescence.

PubMed

Zurcher, Jessica D; Holmgren, Hailey G; Coyne, Sarah M; Barlett, Christopher P; Yang, Chongming

2018-05-01

Cyberbullying perpetration continues to be a prevalent and harmful phenomenon. Despite the recent wealth of studies that examine cyberbullying frequency, further research is needed to investigate protective factors or variables that decrease the likelihood of engaging in cyberbullying perpetration. Past work has identified certain types of parenting as a potential protective factor against adolescent cyberbullying perpetration; however, there is a paucity of research testing these relations over time. This study explores parenting during early adolescence as predicting attitudes and behaviors associated with cyberbullying in late adolescence. Data were derived from the Flourishing Families Project (FFP) at Wave 2 (M age = 12) and Wave 9 (M age = 19). Results suggest that the authoritative parenting style-specifically the warmth and support dimension-was associated with less supportive attitudes toward cyberbullying and lower levels of cyberbullying in emerging adulthood. Moreover, particularly for boys, authoritarian parenting behaviors served as a risk factor for cyberbullying engagement. Suggestions are offered to advocate for greater positive parenting education during early adolescence as a potential protective factor against cyberbullying.

The Council of Academic Hospitals of Ontario (CAHO) Adopting Research to Improve Care (ARTIC) Program: Reach, Sustainability, Spread and Lessons Learned from an Implementation Funding Model.

PubMed

Moore, Julia E; Grouchy, Michelle; Graham, Ian D; Shandling, Maureen; Doyle, Winnie; Straus, Sharon E

2016-05-01

Despite evidence on what works in healthcare, there is a significant gap in the time it takes to bring research into practice. The Council of Academic Hospitals of Ontario's Adopting Research to Improve Care program addresses this research-to-practice gap by incorporating the following components into its funding program: strategic selection of evidence for implementation, education and training for implementation, implementation supports, executive champions and governance, and evaluation. Funded projects have been sustained (76% reported full sustainability) and spread to over 200 new sites. Lessons learned include the following: assess readiness, develop tailored implementation materials, consider characteristics of implementation supports, protect champion time and consider evaluation feasibility. Copyright © 2016 Longwoods Publishing.

The Council of Academic Hospitals of Ontario (CAHO) Adopting Research to Improve Care (ARTIC) Program: Reach, Sustainability, Spread and Lessons Learned from an Implementation Funding Model

PubMed Central

Grouchy, Michelle; Graham, Ian D.; Shandling, Maureen; Doyle, Winnie; Straus, Sharon E.

2016-01-01

Despite evidence on what works in healthcare, there is a significant gap in the time it takes to bring research into practice. The Council of Academic Hospitals of Ontario's Adopting Research to Improve Care program addresses this research-to-practice gap by incorporating the following components into its funding program: strategic selection of evidence for implementation, education and training for implementation, implementation supports, executive champions and governance, and evaluation. Funded projects have been sustained (76% reported full sustainability) and spread to over 200 new sites. Lessons learned include the following: assess readiness, develop tailored implementation materials, consider characteristics of implementation supports, protect champion time and consider evaluation feasibility. PMID:27232234

40 CFR 26.1113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Suspension or termination of IRB approval of research. 26.1113 Section 26.1113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for...

40 CFR 26.1113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Suspension or termination of IRB approval of research. 26.1113 Section 26.1113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for...

40 CFR 26.1113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Suspension or termination of IRB approval of research. 26.1113 Section 26.1113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for...

40 CFR 26.1113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Suspension or termination of IRB approval of research. 26.1113 Section 26.1113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for...

40 CFR 26.1113 - Suspension or termination of IRB approval of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Suspension or termination of IRB approval of research. 26.1113 Section 26.1113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for...

Risk and resilience in an uncertain world

DOE PAGES

Dale, Virginia H.; Jager, Henriette I.; Wolfe, Amy K.; ...

2018-02-01

We report that because the future is uncertain and to some extent unknowable, it is imperative that ecologists become involved in the discussion and planning of future infrastructure and protection from the effects of altered disturbance regimes. Research can test and demonstrate the benefits of protecting or proactively managing important features and places, and processes that enhance provisioning of ecosystem services such as flood control and fire mitigation. In conclusion, it is time to demonstrate how ecological science, when applied to human–environmental systems, can reduce risks and enhance resilience in a complex, changing world.

Risk and resilience in an uncertain world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dale, Virginia H.; Jager, Henriette I.; Wolfe, Amy K.

We report that because the future is uncertain and to some extent unknowable, it is imperative that ecologists become involved in the discussion and planning of future infrastructure and protection from the effects of altered disturbance regimes. Research can test and demonstrate the benefits of protecting or proactively managing important features and places, and processes that enhance provisioning of ecosystem services such as flood control and fire mitigation. In conclusion, it is time to demonstrate how ecological science, when applied to human–environmental systems, can reduce risks and enhance resilience in a complex, changing world.

10 CFR 35.6 - Provisions for the protection of human research subjects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Provisions for the protection of human research subjects... Information § 35.6 Provisions for the protection of human research subjects. (a) A licensee may conduct research involving human research subjects only if it uses the byproduct materials specified on its license...

10 CFR 35.6 - Provisions for the protection of human research subjects.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Provisions for the protection of human research subjects... Information § 35.6 Provisions for the protection of human research subjects. (a) A licensee may conduct research involving human research subjects only if it uses the byproduct materials specified on its license...

10 CFR 35.6 - Provisions for the protection of human research subjects.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Provisions for the protection of human research subjects... Information § 35.6 Provisions for the protection of human research subjects. (a) A licensee may conduct research involving human research subjects only if it uses the byproduct materials specified on its license...

Is new always better than old?: The development of human vaccines for anthrax.

PubMed

Baillie, Leslie W

2009-12-01

Anthrax is caused by a Gram-positive aerobic spore-forming bacillus called Bacillus anthracis. Although primarily a disease of animals, it can also infect man, sometimes with fatal consequences. As a result of concerns over the illicit use of this organism, considerable effort is focused on the development of therapies capable of conferring protection against anthrax. while effective concerns over the toxicity of the current vaccines have driven the development of second-generation products. Recombinant Protective Antigen (rPA), the nontoxic cell-binding component of anthrax lethal toxin, is the principal immunogen of the vaccines currently undergoing human clinical trials. While these new vaccines are likely to show reduced side effects they will still require multiple needle based dosing and the inclusion of the adjuvant alum which will make them expensive to administer and stockpile. To address these issues, researchers are seeking to develop vaccine formulations capable of stimulating rapid protection following needle-free injection which are stable at room temperature to facilitate stockpiling and mass vaccination programs. Recent concerns over the potential use of molecular biology to engineer vaccine resistant strains has prompted investigators to identify additional vaccine targets with which to extend the spectrum of protection conferred by rPA. While the injection of research dollars has seen a dramatic expansion of the anthrax vaccine field it is sobering to remember that work to develop the current second generation vaccines began around the time of the first gulf war. Almost two decades and millions of dollars later we still do not have a replacement vaccine and even when we do some argue that the spectrum of protection that it confers will not be as broad as the vaccine it replaces. If we are to respond effectively to emerging biological threats we need to develop processes that generate protective vaccines in a meaningful time frame and yield products in months not decades!

Expanding the Use of Time/Frequency Difference of Arrival Geolocation in the Department of Defense

DTIC Science & Technology

2012-01-01

next decade. Military acquisition and research , development, test , and evaluation will likely be the hardest hit by spending cuts (Eaglen and Nguyen...Unauthorized posting of RAND electronic documents to a non-RAND website is prohibited. RAND electronic documents are protected under copyright law...Permission is required from RAND to reproduce, or reuse in another form, any of our research documents for commercial use. For information on reprint

Protected Resident Research Time Does Not Increase the Quantity or Quality of Residency Program Research Publications: A Comparison of 3 Orthopedic Residencies.

PubMed

Krueger, Chad A; Hoffman, Jeffery D; Balazs, George C; Johnson, Anthony E; Potter, Benjamin K; Belmont, Philip J

The effect of dedicated resident research time in terms of residency program research productivity remains largely unknown. We hypothesize that the quantity and quality of a residency program's peer-reviewed publications (PRPs) increase proportionately with the amount of dedicated research time given to residents. Three residency programs (P1, P2, and P3) were examined. P1 has a mandatory research year for all residents between postgraduate years 3 and 4. P2 has an elective research year for 1 resident between postgraduate years 2 and 3. P3 has no dedicated research time for residents. All publications produced by residents and staff at each program from January 2007 through December were recorded from PUBMED. SCImago Journal Rankings were used as a proxy to measure research quality. There was no significant difference in the number of publications produced between the institutions on a per-staff (p = 0.27) and per-resident (p = 0.80) basis. There were no residents at P3 who graduated without at least 1 PRP, whereas there were 7 residents from P1 and 8 residents from P2 who graduated without a PRP. There were no significant differences between programs in terms of the SCImago Journal Ranking for the journals containing their publications (p = 0.135). Residency programs with dedicated research time did not produce significantly (p > 0.05) more, or higher quality, PRPs than residencies without dedicated research time. It may be that the quantity and quality of PRPs is related more to faculty engagement, research interest, and mentorship at individual programs rather than the number of residents given dedicated time to complete research. Level 3. Published by Elsevier Inc.

DEVELOPMENT OF REAL-TIME SITE-SPECIFIC MICROSCALE EMISSION FACTOR MODEL FOR THE ASSESSMENT OF HUMAN EXPOSURE TO MOTOR VEHICLE EMISSIONS

EPA Science Inventory

The United States Environmental Protection Agency's (EPA) National Expsoure Research Laboratory (NERL) has initiated a project to improve the methodology for modeling urban-scale human exposure to mobile source emissions. The modeling project has started by considering the nee...

DEVELOPMENT OF A MICROSCALE EMISSION FACTOR MODEL FOR PARTICULATE MATTER (MICROFACPM) FOR PREDICTING REAL-TIME MOTOR VEHICLE EMISSIONS

EPA Science Inventory

The United States Environmental Protection Agency's National Exposure Research Laboratory has initiated a project to improve the methodology for modeling human exposure to motor vehicle emissions. The overall project goal is to develop improved methods for modeling the source t...

DEVELOPMENT OF A MICROSCALE EMISSION FACTOR MODEL FOR CO (MICROFACCO) FOR PREDICTING REAL-TIME VEHICLE EMISSIONS

EPA Science Inventory

The United States Environmental Protection Agency's National Exposure Research Laboratory has initiated a project to improve the methodology for modeling human exposure to motor vehicle emissions. The overall project goal is to develop improved methods for modeling the source t...

DEVELOPMENT OF A MICROSCALE EMISSION FACTOR MODEL FOR PARTICULATE MATTER (MICROFACPM) FOR PREDICTING REAL-TIME MOTOR VEHICLE EMISSIONS

EPA Science Inventory

The United States Environmental Protection Agency's National Exposure Research Laboratory is pursuing a project to improve the methodology for modeling human exposure to motor vehicle emissions. The overall project is to develop improved methods for modeling the source through...

COLLABORATIVE, MULTI-TIME PERIOD LIDAR COLLECTION AND ANALYSIS FOR RESIDENTIAL DEVELOPMENT IMPACT ASSESSMENT AND MONITORING

EPA Science Inventory

The U.S. EPA Environmental Photographic Interpretation Center (EPIC) in

Reston, Virginia is currently conducting collaborative landscape/stream ecology research

in the Clarksburg Special Protection Area (CSPA) in Montgomery County, Maryland.

The CSPA is an ar...

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... initiated after April 7, 2006 involving intentional exposure of a human subject if, at any time prior to... additional protections for human subjects. (e) This subpart does not affect any State or local laws or...

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... initiated after April 7, 2006 involving intentional exposure of a human subject if, at any time prior to... additional protections for human subjects. (e) This subpart does not affect any State or local laws or...

78 FR 59040 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

..., [email protected] . Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated... Scientific Review Special Emphasis Panel, RFA Panel: Molecular Probes. Date: October 18, 2013. Time: 8:00 a.m... Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93...

Experimental impact protection with advanced restraint systems : preliminary primate with air bag and inertia reel/inverted-y yoke torso harness.

DOT National Transportation Integrated Search

1969-02-01

Both the inverted-Y yoke torso harness with inertia reel and the air- bag restraint system have had extensive independent development for some time by several engineering and research organizations for both aviation and ground vehicle occupant protec...

Emerging Tools to Estimate and to Predict Exposures to Chemicals

EPA Science Inventory

The timely assessment of the human and ecological risk posed by thousands of existing and emerging commercial chemicals is a critical challenge facing EPA in its mission to protect public health and the environment The US EPA has been conducting research to enhance methods used t...

Time for a Sport Sex-Discrimination Uprising of a Different Sort

ERIC Educational Resources Information Center

Lopiano, Donna A.

2013-01-01

Research on the frequency of athlete sexual abuse in the United States is almost nonexistent. However, anecdotal data from news reports abound. This article offers an advocacy agenda of strong steps that can be taken to protect athletes from coach sexual abuse, especially female athletes.

Computer Virus Bibliography, 1988-1989.

ERIC Educational Resources Information Center

Bologna, Jack, Comp.

This bibliography lists 14 books, 154 journal articles, 34 newspaper articles, and 3 research papers published during 1988-1989 on the subject of computer viruses, software protection and 'cures', virus hackers, and other related issues. Some of the sources listed include Computers and Security, Computer Security Digest, PC Week, Time, the New…

40 CFR 18.6 - Method of Application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Method of Application. 18.6 Section 18.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.6 Method of...

Legal considerations and cooperative opportunities for space commercial activities

NASA Technical Reports Server (NTRS)

Hosenball, S. N.

1984-01-01

It is a national policy to make the capabilities of the Space Transportation System available to a wide range of potential users. This includes its availability as a space manufacturing facility for commercial activities, which may be carried out on a reimbursable basis or as a joint endeavor with NASA, but with substantial private investment. In any high risk, long lead-time research and development activity directed towards commercialization, the protection afforded the results of the research and development under the laws relating to intellectual property rights may provide an important incentive for private investment. The policies and practices of NASA directed towards the protection of privately-established intellectual property rights involved in STS use are reviewed with particular emphasis on reimbursable launch agreements and joint endeavor agreements.

Space Shuttle, private enterprise and intellectual properties in the context of space manufacturing

NASA Technical Reports Server (NTRS)

Hosenball, S. N.; Kempf, R. F.

1983-01-01

It is a national policy to make the capabilities of the Space Transportat ion System available to a wide range of potential users. This includes its availability as a space manufacturing facility for commercial activities, which may be carried out on a reimbursable basis or as a joint endeavor with NASA, but with substantial private investment. In any high risk, long lead-time research and development activity directed towards commercialization, the protection afforded the results of the research and development under the laws relating to intellectual property rights may provide an important incentive for private investment. The paper reviews NASA's policies and practices for the protection of privately-established intellectual property rights involved in STS use, with particular emphasis on reimbursable launch agreements and joint endeavor agreements.

Building capacity for research in family medicine: is the blueprint faulty?

PubMed

Curtis, Peter; Dickinson, Perry; Steiner, John; Lanphear, Bruce; Vu, Kieu

2003-02-01

This study compared the training programs and career paths of family medicine graduates in the National Research Service Award (NRSA) Program for Research in Primary Medical Care with general internal medicine and general pediatric peers. We mailed a survey to NRSA fellows graduating from 23 programs nationally between 1988-1997. Personal characteristics, fellowship experience, current professional activities, and academic productivity were compared among primary care disciplines. Of 215 NRSA participants, 146 (68%) completed the survey. Of the 131 primary care respondents, 25% were family physicians. During the fellowship, family physician trainees spent significantly less time in hands-on research activity (32% +/- 12%) than internists and pediatricians (39% +/- 17%). Family physician graduates also had less post-fellowship mentoring and were less likely to hold clinician/researcher faculty positions in academic centers. Family physician faculty spent far more time on clinical work and less time on research. Only 12.5% of family physician fellowship graduates published one or more articles per year, compared with 36.5% of their peers, and 30% had published nothing since graduation. Family physician graduates of this research training program did not achieve academic success comparable to their peers. Family physicians need more protected time for conducting research in their faculty positions and more sustained mentorship.

Views of female breast cancer patients who donated biologic samples regarding storage and use of samples for genetic research.

PubMed

Kaphingst, K A; Janoff, J M; Harris, L N; Emmons, K M

2006-05-01

Although social and ethical issues related to the storage and use of biologic specimens for genetic research have been discussed extensively in the medical literature, few empiric data exist describing patients' views. This qualitative study explored the views of 26 female breast cancer patients who had consented to donate blood or tissue samples for breast cancer research. Participants generally did not expect personal benefits from research and had few unprompted concerns. Few participants had concerns about use of samples for studies not planned at the time of consent. Some participants did express concerns about insurance or employment discrimination, while others believed that current privacy protections might actually slow breast cancer research. Participants were generally more interested in receiving individual genetic test results from research studies than aggregate results. Most participants did not want individual results of uncertain clinical significance, although others believed that they should be able to receive such information. These data examined the range of participants' views regarding the storage and use of biologic samples. Further research with different and diverse patient populations is critical to establishing an appropriate balance between protecting the rights of human subjects in genetic research and allowing research to progress.

40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

Code of Federal Regulations, 2010 CFR

2010-07-01

... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26.1110 Section 26.1110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF... kinds of research involving no more than minimal risk, and for minor changes in approved research. (a...

Culturally Relevant Human Subjects Protection Training: A Case Study in Community-Engaged Research in the United States.

PubMed

Kue, Jennifer; Szalacha, Laura A; Happ, Mary Beth; Crisp, Abigail L; Menon, Usha

2018-02-01

Non-academic members of research teams, such as community members, can perceive traditional human subjects protection training as lacking in cultural relevance. We present a case exemplar of the development of a human subjects protection training for research staff with limited English proficiency and/or no or limited research experience. Seven modules were adapted for language, cultural examples, etc., from the standard Collaborative Institutional Training Initiative (CITI) human subjects protection training. Non-academic research staff completed a day-long training in human subjects protection (six modules) and our research protocol (one module). We assessed comprehension of content with PowerPoint slides and module quizzes. All participants successfully passed each module quiz with ≥ 80% correct. Questions answered incorrectly were discussed before proceeding to the next module. To meet the increasing demand for collaborative community-engaged research with underserved minority populations, human subjects protection training protocols can be adapted successfully to reflect real-world situations and provide culturally relevant materials to help non-academic research staff better understand the importance and necessity of research ethics.

76 FR 78660 - Solicitation of Nominations for Membership on the Secretary's Advisory Committee on Human...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

.... Specifically, the Committee provides advice relating to the responsible conduct of research involving human... Secretary's Advisory Committee on Human Research Protections AGENCY: Office for Human Research Protections... Human Research Protections (OHRP), a program office in the Office of the Assistant Secretary for Health...

76 FR 75825 - Streamlining Inherited Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... submitting comments. Mail: Research, Markets & Regulations Division, Bureau of Consumer Financial Protection... Lieu of Mail: Research, Markets & Regulations Division, Bureau of Consumer Financial Protection, 1700 G..., Counsel, Research, Markets & Regulations Division, Bureau of Consumer Financial Protection, (202) 453-7700...

34 CFR 97.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.120... adequacy of protection against these risks, the potential benefits of the research to the subjects and...

The Role of Parental Engagement in the Intergenerational Transmission of Smoking Behavior and Identity.

PubMed

Gottfredson, Nisha C; Hussong, Andrea M; Ennett, Susan T; Rothenberg, W Andrew

2017-05-01

Prior research has found that the protective effect of parental engagement on adolescent smoking behaviors may be weaker if parents smoke. We examine parental influence on adolescent smoking using a social learning theory framework. We hypothesize that adolescents are more likely to mimic parental smoking behavior if they perceive parents as being more engaged and if the parent is the same gender of the adolescent. Hypotheses were tested using a diverse sample of 6,998 adolescents who were followed for seven waves (grades 6-12). Adolescent gender, time-stable and time-varying effects of parental engagement, adolescent perceptions of parental smoking, and interactions among the effects of these variables are tested using multilevel mediation models. We use a traditional measure of past 3-month adolescent smoking and a novel measure of smoking identity. Parental smoking was associated with a developmental increase in adolescent smoking and time-stable and time-varying parental engagement protected against adolescent smoking, whereas maternal engagement and smoking exerted independent and opposite effects with no moderation and time-stable paternal engagement moderated the effects of perceived paternal smoking on adolescent smoking outcomes. Parental smoking was more strongly associated with adolescent smoking outcomes when adolescent gender was congruent with parent gender. Even when parents smoke, parental engagement confers protection. Protective effects of engagement may be enhanced among parents who smoke through increased antismoking communication, particularly as adolescents reach the legal smoking age. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

A healthy dose of scepticism: four good reasons to think again about protective effects of alcohol on coronary heart disease.

PubMed

Chikritzhs, Tanya; Fillmore, Kaye; Stockwell, Tim

2009-07-01

Alcohol has been implicated in both the popular press and scientific literature as having a protective effect for at least a dozen conditions including coronary heart disease (CHD). Epidemiological evidence for an apparent protective effect of alcohol on CHD is now being challenged on a number of fronts. This paper is a synopsis of those various challenges as they currently stand. The argument that systematic misclassification of ex-drinkers and occasional drinkers to 'abstainer' categories among epidemiological studies might explain apparent protective effects of moderate alcohol consumption on CHD has recently been supported by new meta-analyses and independent research. The influence of uncontrolled or unknown factors on the relationship between alcohol and disease cannot be ruled out. Exclusion of participants on the basis of ill-health severely reduces study sample size and new analyses suggest that doing so might artificially create the appearance of protective effects. The ability of respondents to accurately recall their own alcohol consumption is in serious doubt and very few individuals maintain one single drinking level or style throughout life. The relationship between alcohol and some conditions might be a function of drinking patterns but few studies have addressed the issue. Popular perceptions regarding the strength of evidence for alcohol's protective effect on a growing number of conditions might be misguided. It is time for the wider research, health and medical community to seriously reflect on the quality of current evidence for apparent protective effects of alcohol on human disease.

Research ethics across the 49th parallel: the potential value of pilot testing "equivalent protections" in Canadian research institutions.

PubMed

Lavery, James V; McDonald, Michael; Meslin, Eric M

2005-01-01

Canada and the United States share the world's largest trade partnership and an increasing concern about divergent regulatory approaches to common industries. Canadian research institutes receive more research funding from the U.S. National Institutes of Health than any other country, much of it to fund multi-centre and collaborative research between the two countries. Because of these close economic and research ties, and the extensive similarities between the two countries in the review and oversight of ethics in human subjects research, we propose that Canada would be an ideal country for a pilot-test of the feasibility of "equivalent protections," a U.S. regulation that permits comparison of protections for human subjects between institutions in the two countries. The "equivalent protections" has been advocated by various bodies in the United States as a potentially beneficial mechanism for improving oversight of foreign trials. As well, we argue that "equivalent protections" could prove to be valuable for Canada in five specific ways: (1) by potentially reducing administrative burden on Canadian research institutions administering U.S. federal research funding; (2) by creating symbolic value of an explicit recognition by the United States that procedures normally followed for the protection of human subjects in Canadian research institutions are at least equivalent to those provided by the U.S. regulations; (3) by lowering the opportunity cost of investing in research in Canada; (4) by affording Canada an opportunity to enhance its leadership role in international research by offering an alternative to the U.S. regulatory model for the protection of human subjects; and (5) by providing a model for how the idea of equivalent protections might be addressed for research funded by Canadian agencies but conducted in other countries.

The hidden face of academic researches on classified highly pathogenic microorganisms.

PubMed

Devaux, Christian A

2015-01-01

Highly pathogenic microorganisms and toxins are manipulated in academic laboratories for fundamental research purposes, diagnostics, drugs and vaccines development. Obviously, these infectious pathogens represent a potential risk for human and/or animal health and their accidental or intentional release (biosafety and biosecurity, respectively) is a major concern of governments. In the past decade, several incidents have occurred in laboratories and reported by media causing fear and raising a sense of suspicion against biologists. Some scientists have been ordered by US government to leave their laboratory for long periods of time following the occurrence of an incident involving infectious pathogens; in other cases laboratories have been shut down and universities have been forced to pay fines and incur a long-term ban on funding after gross negligence of biosafety/biosecurity procedures. Measures of criminal sanctions have also been taken to minimize the risk that such incidents can reoccur. As United States and many other countries, France has recently strengthened its legal measures for laboratories' protection. During the past two decades, France has adopted a series of specific restriction measures to better protect scientific discoveries with a potential economic/social impact and prevent their misuse by ill-intentioned people without affecting the progress of science through fundamental research. French legal regulations concerning scientific discoveries have progressively strengthened since 2001, until the publication in November 2011 of a decree concerning the "PPST" (for "Protection du Potentiel Scientifique et Technique de la nation", the protection of sensitive scientific data). Following the same logic of protection of sensitive scientific researches, regulations were also adopted in an order published in April 2012 concerning the biology and health field. The aim was to define the legal framework that precise the conditions for authorizing microorganisms and toxins experimentation in France; these regulations apply for any operation of production, manufacturing, transportation, import, export, possession, supply, transfer, acquisition and use of highly pathogenic microorganisms and toxins, referred to as "MOT" (for "MicroOrganismes et Toxines hautement pathogènes") by the French law. Finally, laboratories conducting researches on such infectious pathogens are henceforth classified restricted area or ZRR (for "Zone à Régime Restrictif"), according an order of July 2012. In terms of economic protection, biosafety and biosecurity, these regulations represent an undeniable progress as compared to the previous condition. However, the competitiveness of research laboratories handling MOTs is likely to suffer the side effects of these severe constraints. For example research teams working on MOTs can be drastically affected both by (i) the indirect costs generated by the security measure to be applied; (ii) the working time devoted to samples recording; (iii) the establishment of traceability and reporting to national security agency ANSM, (iv) the latency period required for staff members being officially authorized to conduct experiments on MOTs; (v) the consequent reduced attractiveness for recruiting new trainees whose work would be significantly hampered by theses administrative constraints; and (vi) the limitations in the exchange of material with external laboratories and collaborators. Importantly, there is a risk that French academic researchers gradually abandon research on MOTs in favor of other projects that are less subject to legal restrictions. This would reduce the acquisition of knowledge in the field of MOTs which, in the long term, could be highly detrimental to the country by increasing its vulnerability to natural epidemics due to pathogenic microorganisms that are classified as MOTs and, by reducing its preparedness against possible bioterrorist attacks that would use such microorganisms. Copyright © 2014 Elsevier B.V. All rights reserved.

Certificates of Confidentiality: Protecting Human Subject Research Data in Law and Practice

PubMed Central

Patel, Mayank J.; Williams, Brett A.; Austin, Jeffrey L.; Dame, Lauren A.

2014-01-01

Researchers often require and collect sensitive information about individuals to answer important scientific questions that impact individual health and well-being and the public health. Researchers recognize they have a duty to maintain the confidentiality of the data they collect and typically make promises, which are documented in the consent form. The legal interests of others, however, can threaten researchers’ promises of confidentiality, if they seek access to the data through subpoena. Certificates of Confidentiality (Certificates), authorized by federal statute, are an important tool for protecting individually identifiable sensitive research data from compelled disclosure. However, questions persist in the research community about the strength of Certificate protections, and the evidence on which to judge the strength is scant. In this article, we address those questions through a careful examination of the legislation and regulations concerning Certificates and the reported and unreported cases we have identified through our legal research and interviews with legal counsel about their experiences with Certificates. We also analyze other statutes that protect research data to compare them to the Certificate’s protections, and we review other legal strategies available for protecting research data. Based on our analysis, we conclude with recommendations for how to strengthen protection of sensitive research data. PMID:25392705

RESULTS OF RESEARCH RELATED TO STRATOSPHERIC OZONE PROTECTION

EPA Science Inventory

Research on ozone protection has been coordinated under the Biological and Climatic Effects Research (BACER) Program. This is a multiagency, multidisciplinary effort initially funded by The Environmental Protection Agency. Its purpose is to reduce uncertainties regarding ozone de...

Understanding community-based processes for research ethics review: a national study.

PubMed

Shore, Nancy; Brazauskas, Ruta; Drew, Elaine; Wong, Kristine A; Moy, Lisa; Baden, Andrea Corage; Cyr, Kirsten; Ulevicus, Jocelyn; Seifer, Sarena D

2011-12-01

Institutional review boards (IRBs), designed to protect individual study participants, do not routinely assess community consent, risks, and benefits. Community groups are establishing ethics review processes to determine whether and how research is conducted in their communities. To strengthen the ethics review of community-engaged research, we sought to identify and describe these processes. In 2008 we conducted an online survey of US-based community groups and community-institutional partnerships involved in human-participants research. We identified 109 respondents who met participation criteria and had ethics review processes in place. The respondents' processes mainly functioned through community-institutional partnerships, community-based organizations, community health centers, and tribal organizations. These processes had been created primarily to ensure that the involved communities were engaged in and directly benefited from research and were protected from research harms. The primary process benefits included giving communities a voice in determining which studies were conducted and ensuring that studies were relevant and feasible, and that they built community capacity. The primary process challenges were the time and resources needed to support the process. Community-based processes for ethics review consider community-level ethical issues that institution-based IRBs often do not.

Issues in protection of human subjects in internet research.

PubMed

Im, Eun-Ok; Chee, Wonshik

2002-01-01

Despite the increasing use of the Internet among nurses, the use of the Internet in nursing research has been rarely discussed and critiqued in terms of issues in protection of human subjects. In this article, issues in protection of human subjects in Internet research are explored by analyzing an Internet study to propose directions for human protection in Internet research. Issues raised through the study include those related to (a) anonymity and confidentiality, (b) security, (c) self-determination and authenticity, (d) full disclosure, and (e) fair treatment. Based on discussion of the five issues, development of standardized guidelines, investigator triangulation, and information sharing are proposed as directions for protection of human subjects in Internet research.

22 CFR 225.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-04-01

..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or... responsibilities for protecting the rights and welfare of human subjects of research conducted at or sponsored by...

40 CFR 26.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Subjects in Human Research Conducted or Supported by EPA § 26.103 Assuring compliance with this..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or...

28 CFR 46.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or... responsibilities for protecting the rights and welfare of human subjects of research conducted at or sponsored by...

34 CFR 97.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.103 Assuring compliance with this..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, (HHS), or any successor office. (b) Departments and agencies will conduct or...

45 CFR 46.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Protection of Human Research Subjects § 46.103 Assuring compliance with this policy—research conducted or... file with the Office for Human Research Protections, HHS, or any successor office, and approved for... department and agency heads shall also be made to the Office for Human Research Protections, HHS, or any...

16 CFR 1028.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-01-01

..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or... responsibilities for protecting the rights and welfare of human subjects of research conducted at or sponsored by...

15 CFR 27.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-01-01

..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or... responsibilities for protecting the rights and welfare of human subjects of research conducted at or sponsored by...

49 CFR 11.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, HHS, or any successor office. (b) Departments and agencies will conduct or... responsibilities for protecting the rights and welfare of human subjects of research conducted at or sponsored by...

40 CFR 26.109 - IRB review of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 26.109 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.109 IRB... subjects when in the IRB's judgment the information would meaningfully add to the protection of the rights...

Cyberpark 2000: Protected Areas Management Pilot Project. Satellite time series vegetation monitoring

NASA Astrophysics Data System (ADS)

Monteleone, M.; Lanorte, A.; Lasaponara, R.

2009-04-01

Cyberpark 2000 is a project funded by the UE Regional Operating Program of the Apulia Region (2000-2006). The main objective of the Cyberpark 2000 project is to develop a new assessment model for the management and monitoring of protected areas in Foggia Province (Apulia Region) based on Information and Communication Technologies. The results herein described are placed inside the research activities finalized to develop an environmental monitoring system knowledge based on the use of satellite time series. This study include: - A- satellite time series of high spatial resolution data for supporting the analysis of fire static risk factors through land use mapping and spectral/quantitative characterization of vegetation fuels; - B- satellite time series of MODIS for supporting fire dynamic risk evaluation of study area - Integrated fire detection by using thermal imaging cameras placed on panoramic view-points; - C - integrated high spatial and high temporal satellite time series for supporting studies in change detection factors or anomalies in vegetation covers; - D - satellite time-series for monitoring: (i) post fire vegetation recovery and (ii) spatio/temporal vegetation dynamics in unburned and burned vegetation covers.

To share or not to share? Expected pros and cons of data sharing in radiological research.

PubMed

Sardanelli, Francesco; Alì, Marco; Hunink, Myriam G; Houssami, Nehmat; Sconfienza, Luca M; Di Leo, Giovanni

2018-06-01

The aims of this paper are to illustrate the trend towards data sharing, i.e. the regulated availability of the original patient-level data obtained during a study, and to discuss the expected advantages (pros) and disadvantages (cons) of data sharing in radiological research. Expected pros include the potential for verification of original results with alternative or supplementary analyses (including estimation of reproducibility), advancement of knowledge by providing new results by testing new hypotheses (not explored by the original authors) on pre-existing databases, larger scale analyses based on individual-patient data, enhanced multidisciplinary cooperation, reduced publication of false studies, improved clinical practice, and reduced cost and time for clinical research. Expected cons are outlined as the risk that the original authors could not exploit the entire potential of the data they obtained, possible failures in patients' privacy protection, technical barriers such as the lack of standard formats, and possible data misinterpretation. Finally, open issues regarding data ownership, the role of individual patients, advocacy groups and funding institutions in decision making about sharing of data and images are discussed. • Regulated availability of patient-level data of published clinical studies (data-sharing) is expected. • Expected benefits include verification/advancement of knowledge, reduced cost/time of research, clinical improvement. • Potential drawbacks include faults in patients' identity protection and data misinterpretation.

40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

Code of Federal Regulations, 2010 CFR

2010-07-01

... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26.110 Section 26.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF... risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and...

An Empirical Ethics Agenda for Psychiatric Research Involving Prisoners

PubMed Central

Christopher, Paul P.; Candilis, Philip J.; Rich, Josiah D.; Lidz, Charles W.

2012-01-01

In the past 30 years, the incarcerated population in the United States has more than quadrupled to 2.3 million adults. With an alarmingly high prevalence of mental illness, substance use, and other serious health conditions compounding their curtailed autonomy, prisoners constitute perhaps the nation’s most disadvantaged group. Scientifically rigorous research involving prisoners holds the potential to inform and enlighten correctional policy and to improve their treatment. At the same time, prisoner research presents significant ethical challenges to investigators and institutional review boards (IRBs) alike, by subjecting participants to conditions that potentially undermine the validity of their informed consent. In 2006, the Institute of Medicine Committee on Ethical Considerations for Revisions to the Department of Health and Human Services (DHHS) Regulations for Protection of Prisoners Involved in Research recommended both further protections and a more permissive approach to research review that would allow inmates greater access to potentially beneficial research. These recommendations have sparked renewed debate about the ethical trade-offs inherent to prisoner research. In this article, the authors review the major justifications for research with prisoner subjects and the associated ethical concerns, and argue that the field of empirical ethics has much to offer to the debate. They then propose a framework for prioritizing future empirical ethics inquiry on this understudied topic. PMID:25309805

Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat.

PubMed

Whitsett, Timothy G; Lamartiniere, Coral A

2006-12-01

The environment, including diet, plays a critical role in a woman's subsequent risk of breast cancer. Two dietary polyphenols that have received attention from the health and research communities for their ability to protect against breast cancer are: genistein, a component of soy; and resveratrol, a phytoalexin found in red grapes and red wine. We and others have shown that both genistein and resveratrol can protect against mammary cancer in rodents. The timing of exposure to genistein appears critical for its mammary protective effects. It has been reported that genistein early in life causes enhanced mammary gland differentiation, alterations in cell proliferation and apoptosis, and upregulation of tumor-suppressor genes. With resveratrol in the diet, changes in cell proliferation and apoptosis in terminal ductal structures of the mammary gland might help to explain its protective effects. We conclude that genistein and resveratrol can protect against breast cancer by regulating important mammary growth and differentiation pathways.

40 CFR 52.272 - Research operations exemptions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Research operations exemptions. 52.272 Section 52.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.272 Research operations...

40 CFR 52.272 - Research operations exemptions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Research operations exemptions. 52.272 Section 52.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.272 Research operations...

40 CFR 52.272 - Research operations exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Research operations exemptions. 52.272 Section 52.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.272 Research operations...

A pragmatic analysis of vulnerability in clinical research.

PubMed

Wendler, David

2017-09-01

Identifying which subjects are vulnerable, and implementing safeguards to protect them, is widely regarded as essential to clinical research. Commentators have endorsed a number of responses to these challenges and have thereby made significant progress in understanding vulnerability in clinical research. At the same time, this literature points to a central contradiction which calls into question its potential to protect vulnerable subjects in practice. Specifically, analysis suggests that all human subjects are vulnerable and vulnerability in clinical research is comparative and context dependent, in the sense that individuals are vulnerable relative to others and in some contexts only. Yet, if everyone is vulnerable, there seems to be no point in citing the vulnerability of some individuals. Moreover, the conclusion that everyone is vulnerable seems inconsistent with the claims that vulnerability is comparative and context dependent, raising concern over whether it will be possible to develop a comprehensive account of vulnerability that is internally consistent. The solution to this dilemma lies in recognition of the fact that the practical significance of claims regarding vulnerability depends on the context in which they are used. The claims that appear to lead to the central contradiction are in fact accurate conclusions that follow from different uses of the term 'vulnerability'. The present manuscript describes this 'pragmatic' approach to vulnerability in clinical research and considers its implications for ensuring that subjects receive appropriate protection. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Enhancing Social Responsibility and Prosocial Leadership to Prevent Aggression, Peer Victimization, and Emotional Problems in Elementary School Children.

PubMed

Leadbeater, Bonnie J; Thompson, Kara; Sukhawathanakul, Paweena

2016-12-01

Testing the theories that form the basis of prevention programs can enhance our understanding of behavioral change and inform the development, coordination, and adaptation of prevention programs. However, theories of change showing the linkages from intervention program components to risk or protective factors to desired outcomes across time are rarely specified or tested. In this 2-year longitudinal study, we test the theory that increases in two protective factors (i.e., children's prosocial leadership and their teachers' expectations of social responsibility) targeted by the WITS Programs (Walk Away, Ignore, Talk it Out, and Seek Help) would be associated with declines in peer victimization, aggression, and emotional problems. Participants included Canadian students, in grades 1-4 at baseline (n = 1329) and their parents and teachers. Consistent with our theory of change, variability in program implementation (adherence and integration) and in children's use of program skills (child responsiveness) are related to increases in both protective factors. Increases in these protective factors are associated with subsequent declines in children's aggression, victimization, and emotional problems. We discuss how enhancement of these protective factors may operate to improve child outcomes and the need for theory-based research to refine and improve the effectiveness of intervention strategies and to improve program scale-up. © Society for Community Research and Action 2016.

The ethics of neonatal research: An ethicist's and a parents' perspective.

PubMed

Janvier, Annie; Farlow, Barbara

2015-12-01

The ethics of neonatal research are complex because vulnerable new parents are asked to provide consent on behalf of their fragile baby. Whereas clinical neonatal care has evolved to value personalized and shared decision-making, the goal of research ethics is still to standardize the informed consent process and make it as complete and thorough as possible. Ethicists, lawyers and physicians have shaped the field of research ethics and consent for research. The goal of detailed informed consent is to protect participants from harm, but procedures were developed without input from the principal stakeholders: ex-neonatal intensive care unit parents/patients. Empirical investigations examining patient and parental perspectives on research and research ethics are lacking. Rigorous investigations are needed to determine how parents of sick neonates want their families to be protected, knowing that a lack of research is also harmful. Large randomized controlled multicenter trials will always be needed to improve neonatal outcomes. These trials are costly and time-consuming. Currently, the way in which research is funded and regulated and the way in which academic merit is recognized lead to inefficiency and a waste of precious resources. Following a review of the history of research ethics, this article examines and discusses the ethics of research in neonatology. In addition, challenges and opportunities are identified and ideas for future investigations are proposed. Copyright © 2015 Elsevier Ltd. All rights reserved.

Applying Triple-Matrix Masking for Privacy Preserving Data Collection and Sharing in HIV Studies.

PubMed

Pei, Qinglin; Chen, Shigang; Xiao, Yao; Wu, Samuel S

2016-01-01

Many HIV research projects are plagued by the high missing rate of selfreported information during data collection. Also, due to the sensitive nature of the HIV research data, privacy protection is always a concern for data sharing in HIV studies. This paper applies a data masking approach, called triple-matrix masking [1], to the context of HIV research for ensuring privacy protection during the process of data collection and data sharing. Using a set of generated HIV patient data, we show step by step how the data are randomly transformed (masked) before leaving the patients' individual data collection device (which ensures that nobody sees the actual data) and how the masked data are further transformed by a masking service provider and a data collector. We demonstrate that the masked data retain statistical utility of the original data, yielding the exactly same inference results in the planned logistic regression on the effect of age on the adherence to antiretroviral therapy and in the Cox proportional hazard model for the age effect on time to viral load suppression. Privacy-preserving data collection method may help resolve the privacy protection issue in HIV research. The individual sensitive data can be completely hidden while the same inference results can still be obtained from the masked data, with the use of common statistical analysis methods.

Improving eye safety in citrus harvest crews through the acceptance of personal protective equipment, community-based participatory research, social marketing, and community health workers.

PubMed

Tovar-Aguilar, J Antonio; Monaghan, Paul F; Bryant, Carol A; Esposito, Andrew; Wade, Mark; Ruiz, Omar; McDermott, Robert J

2014-01-01

For the last 10 years, the Partnership for Citrus Workers Health (PCWH) has been an evidence-based intervention program that promotes the adoption of protective eye safety equipment among Spanish-speaking farmworkers of Florida. At the root of this program is the systematic use of community-based preventive marketing (CBPM) and the training of community health workers (CHWs) among citrus harvester using popular education. CBPM is a model that combines the organizational system of community-based participatory research (CBPR) and the strategies of social marketing. This particular program relied on formative research data using a mixed-methods approach and a multilevel stakeholder analysis that allowed for rapid dissemination, effective increase of personal protective equipment (PPE) usage, and a subsequent impact on adoptive workers and companies. Focus groups, face-to-face interviews, surveys, participant observation, Greco-Latin square, and quasi-experimental tests were implemented. A 20-hour popular education training produced CHWs that translated results of the formative research to potential adopters and also provided first aid skills for eye injuries. Reduction of injuries is not limited to the use of safety glasses, but also to the adoption of timely intervention and regular eye hygiene. Limitations include adoption in only large companies, rapid decline of eye safety glasses without consistent intervention, technological limitations of glasses, and thorough cost-benefit analysis.

Common strategic research agenda for radiation protection in medicine.

PubMed

2017-04-01

Reflecting the change in funding strategies for European research projects, and the goal to jointly improve medical radiation protection through sustainable research efforts, five medical societies involved in the application of ionising radiation (European Association of Nuclear Medicine, EANM; European Federation of Organizations for Medical Physics. EFOMP; European Federation of Radiographer Societies, EFRS; European Society of Radiology, ESR; European Society for Radiotherapy and Oncology, ESTRO) have identified research areas of common interest and developed this first edition of the Common Strategic Research Agenda (SRA) for medical radiation protection. The research topics considered necessary and most urgent for effective medical care and efficient in terms of radiation protection are summarised in five main themes: 1. Measurement and quantification in the field of medical applications of ionising radiation 2. Normal tissue reactions, radiation-induced morbidity and long-term health problems 3. Optimisation of radiation exposure and harmonisation of practices 4. Justification of the use of ionising radiation in medical practice 5. Infrastructures for quality assurance The SRA is a living document; thus comments and suggestions by all stakeholders in medical radiation protection are welcome and will be dealt with by the European Alliance for Medical Radiation Protection Research (EURAMED) established by the above-mentioned societies. • Overcome the fragmentation of medical radiation protection research in Europe • Identify research areas of joint interest in the field of medical radiation protection • Improve the use of ionising radiation in medicine • Collect stakeholder feedback and seek consensus • Emphasise importance of clinical translation and evaluation of research results.

The complexity of child protection recurrence: The case for a systems approach.

PubMed

Jenkins, Brian Q; Tilbury, Clare; Mazerolle, Paul; Hayes, Hennessey

2017-01-01

Research on child protection recurrence has found consistent child, family, and case characteristics associated with repeated involvement with the child protection system. Despite the considerable body of empirical research, knowledge about why recurrence occurs, and what can be done to reduce it, is limited. This paper reviews the empirical literature and analyses the approaches of prior recurrence research. Four related conceptual challenges are identified: (1) a tendency to conflate child protection recurrence with repeated child maltreatment; (2) uncertainty about how best to operationalize and measure child protection recurrence in research; (3) inconsistency between prevailing explanations for the most frequently observed patterns of recurrence; and (4) difficulty in developing coherent strategies to address child protection recurrence based on research. Addressing these challenges requires a greater consideration of the effects of decision-making in the child protection system on recurrence. This paper proposes a methodology based in systems theory and drawing on existing administrative data to examine the characteristics of the child protection system that may also produce recurrence. Copyright © 2016 Elsevier Ltd. All rights reserved.

SERDP and ESTCP Workshop on Research and Development Needs for Long-Term Management of Contaminated Sediments

DTIC Science & Technology

2012-10-01

protective of subsistence fishers at an excess life time cancer risk of 1 in one million (1 × 10-6). The trophic transfer model, which is calibrated...In Progress) ER-2135-11, Application of Biofilm Covered Activated Carbon Particles as a Microbial Inoculum Delivery System for Enhanced

78 FR 52937 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; Time-Sensitive Obesity Research. Date...-2542, (301) 594-8898, [email protected] . Name of Committee: National Institute of Diabetes...

From Game Protection to Wildlife Management: Frame Shifts, Organizational Development, and Field Practices

ERIC Educational Resources Information Center

Brulle, Robert J.; Benford, Robert D.

2012-01-01

One enduring question in social movements research is the relationship between cultural representations and organizational structure. In this article, we examine the development of different discursive frames over time, and how such frame shifts affect movement structure and practices. This approach seeks to illuminate the dialectical interplay…

ASSESSING ASTHMATIC CHILDREN'S EXPOSURES TO TOXIC AIR POLLUTANTS AND THE POTENTIAL INHALED DOSES USING TIME ACTIVITY INFORMATION AND ENERGY EXPENDITURE DATA

EPA Science Inventory

Accurately quantifying human exposures and the potential doses of various populations to environmental pollutants is critical for the U.S. Environmental Protection Agency to assess and manage human health risks. The Tampa Asthmatic Children's Study (TACS) was a pilot research stu...

Identifying threats, values, and attributes in Brazilian wilderness areas

Treesearch

Teresa Cristina Magro; Alan Watson; Paula Bernasconi

2007-01-01

The protection of relatively pristine areas in Brazil provides a great opportunity to recognize the values of natural ecosystems. At the same time, it provides opportunities for economic development. The growing interest in these areas in Brazil has stimulated techniques for management and research to study the consequences of human activities on the natural...

EVERGLADES ECOSYSTEM ASSESSMENT: WATER MANAGEMENT AND QUALITY, EUTROPHICATION, MERCURY CONTAMINATION, SOILS AND HABITAT: MONITORING FOR ADAPTIVE MANAGEMENT: A R-EMAP STATUS REPORT

EPA Science Inventory

The United States Environmental Protection Agency’s Everglades Ecosystem Assessment Program is a long-term research, monitoring and assessment effort. Its goal is to provide critical, timely, scientific information needed for management decisions on the Everglades ecosystem and i...

40 CFR 26.304 - Additional protections for pregnant women and fetuses involved in observational research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.304 Additional protections for pregnant women and fetuses involved in observational... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Additional protections for pregnant...

40 CFR 26.304 - Additional protections for pregnant women and fetuses involved in observational research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.304 Additional protections for pregnant women and fetuses involved in observational... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Additional protections for pregnant...

40 CFR 26.304 - Additional protections for pregnant women and fetuses involved in observational research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.304 Additional protections for pregnant women and fetuses involved in observational... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Additional protections for pregnant...

40 CFR 26.304 - Additional protections for pregnant women and fetuses involved in observational research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.304 Additional protections for pregnant women and fetuses involved in observational... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Additional protections for pregnant...

40 CFR 26.304 - Additional protections for pregnant women and fetuses involved in observational research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.304 Additional protections for pregnant women and fetuses involved in observational... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Additional protections for pregnant...

Lightning protection technology for small general aviation composite material aircraft

NASA Technical Reports Server (NTRS)

Plumer, J. A.; Setzer, T. E.; Siddiqi, S.

1993-01-01

An on going NASA (Small Business Innovative Research) SBIR Phase II design and development program will produce the first lightning protected, fiberglass, General Aviation aircraft that is available as a kit. The results obtained so far in development testing of typical components of the aircraft kit, such as the wing and fuselage panels indicate that the lightning protection design methodology and materials chosen are capable of protecting such small composite airframes from lightning puncture and structural damage associated with severe threat lightning strikes. The primary objective of the program has been to develop a lightening protection design for full scale test airframe and verify its adequacy with full scale laboratory testing, thus enabling production and sale of owner-built, lightning-protected, Stoddard-Hamilton Aircraft, Inc. Glasair II airplanes. A second objective has been to provide lightning protection design guidelines for the General Aviation industry, and to enable these airplanes to meet lightening protection requirements for certification of small airplanes. This paper describes the protection design approaches and development testing results obtained thus far in the program, together with design methodology which can achieve the design goals listed above. The presentation of this paper will also include results of some of the full scale verification tests, which will have been completed by the time of this conference.

EPRI Guide to Managing Nuclear Utility Protective Clothing Programs. PCEVAL User`s Manual, A computer code for evaluating the economics of nuclear plant protective clothing programs: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelly, J.J.; Kelly, D.M.

1993-10-01

The Electric Power Research Institute (EPRI) commissioned a radioactive waste related project (RP2414-34) in 1989 to produce a guide for developing and managing nuclear plant protective clothing programs. Every nuclear facility must coordinate some type of protective clothing program for its radiation workers to ensure proper and safe protection for the wearer and to maintain control over the spread of contamination. Yet, every nuclear facility has developed its own unique program for managing such clothing. Accordingly, a need existed for a reference guide to assist with standardizing protective clothing programs and in controlling the potentially escalating economics of such programs.more » The initial Guide to Managing Nuclear Utility Protective Clothing Programs, NP-7309, was published in May 1991. Since that time, a number of utilities have reviewed and/or used the report to enhance their protective clothing programs. Some of these utilities requested that a computer program be developed to assist utilities in evaluating the economics of protective clothing programs consistent with the guidance in NP-7309. The PCEVAL computer code responds to that industry need. This report, the PCEVAL User`s Manual, provides detailed instruction on use of the software.« less

40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human... the protection of the rights and welfare of human subjects (whether or not the research was subject to...

Assessment of tools for protection of quality of water: Uncontrollable discharges of pollutants.

PubMed

Dehghani Darmian, Mohsen; Hashemi Monfared, Seyed Arman; Azizyan, Gholamreza; Snyder, Shane A; Giesy, John P

2018-06-06

Selecting an appropriate crisis management plans during uncontrollable loading of pollution to water systems is crucial. In this research the quality of water resources against uncontrollable pollution is protected by use of suitable tools. Case study which was chosen in this investigation was a river-reservoir system. Analytical and numerical solutions of pollutant transport equation were considered as the simulation strategy to calculate the efficient tools to protect water quality. These practical instruments are dilution flow and a new tool called detention time which is proposed and simulated for the first time in this study. For uncontrollable pollution discharge which was approximately 130% of the river's assimilation capacity, as long as the duration of contact (T c ) was considered as a constraint, by releasing 30% of the base flow of the river from the upstream dilution reservoir, the unallowable pollution could be treated. Moreover, when the affected distance (X c ) was selected as a constraint, the required detention time that the rubber dam should detained the water to be treated was equal to 187% of the initial duration of contact. Copyright © 2018 Elsevier Inc. All rights reserved.

A data protection framework for trans-European genetic research projects.

PubMed

Claerhout, Brecht; Forgó, Nikolaus; Krügel, Tina; Arning, Marian; De Moor, Georges

2008-01-01

The paper proposes a data protection framework for trans-European medical research projects, which is based on a technical security infrastructure as well as on organizational measures and contractual obligations. It mainly relies on pseudonymization, an internal Data Protection Authority and on a Trusted Third Party. The outcome is an environment that combines both good research conditions and an extensive protection of patients' privacy.

77 FR 14287 - Aspergillus flavus AF36; Amendment to an Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... Arizona Cotton Research and Protection Council, Interregional Research Project Number 4 submitted a... College Rd. East, Suite 201W, Princeton, NJ 08540 (on behalf of the Arizona Cotton Research and Protection... petitioner, IR-4 (on behalf of the Arizona Cotton Research and Protection Council), which is available in the...

76 FR 16297 - Aspergillus flavus

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... commodities, when applied/used as an antifungal agent. The Arizona Cotton Research and Protection Council... petition (PP 9E7662) by the Arizona Cotton Research and Protection Council, 3721 East Wier Ave., Phoenix... Cotton Research and Protection Council, which is available in the docket, http://www.regulations.gov...

Certificates of Confidentiality: Protecting Human Subject Research Data in Law and Practice.

PubMed

Wolf, Leslie E; Patel, Mayank J; Williams Tarver, Brett A; Austin, Jeffrey L; Dame, Lauren A; Beskow, Laura M

2015-01-01

The federal Certificate of Confidentiality plays an important role in research on sensitive topics by authorizing researchers to refuse to disclose identifiable research data in response to subpoenas in any legal setting. However, there is little known about how effective Certificates are in practice. This article draws on our legal and empirical research on this topic to fill this information gap. It includes a description of the purpose of Certificates, their legislative and regulatory history, and a summary of the few reported and unreported cases that have dealt with Certificates. In addition, we outline other statutory confidentiality protections, compare them to the Certificate's protections, and analyze some of the vulnerabilities of a Certificate's protections. This analysis allows us to make specific recommendations for strengthening the protections afforded to research data. © 2015 American Society of Law, Medicine & Ethics, Inc.

Local food protection and safety infrastructure and capacity: a Maryland case study.

PubMed

Kufel, Joanna Zablotsky; Resnick, Beth A; Fox, Mary; Frattaroli, Shannon; Gielen, Andrea; Burke, Thomas A

2011-01-01

In Maryland, county Food Protection Programs (FPP), housed within Environmental Public Health (EPH) Divisions, maintain responsibility for regular inspection of all food service facilities (FSF). With growing concerns about how our food supply is protected, it is important to determine the state and effectiveness of our food safety systems. This research elucidates the roles, responsibilities, strengths, and weaknesses of Food Safety and Protection Programs in Maryland. A 16-question survey tool, which addressed facets of the local food protection infrastructure, including FSF inspections, staffing, budget, and foodborne illness surveillance, was distributed to all 24 county FPP. The number of FSF in Maryland increased 97% from 2001 to 2006 and counties had an average inspection completion rate of 73%, with a 4% increase over the time period. Statewide, there were 4.1 EPH full-time employees (FTE) per 10 000 population and 1.6 FPP FTE per 10 000 population. EPH Division budgets increased 63% statewide, from $19.5 million in 2000 to $31.9 million in 2007. FPP budgets also increased 59% over the period, from $6.2 million in 2000 to $9.8 million in 2007. This study offers new quantitative measures of the demands, capacities, and performance of Food Protection and Safety Programs in Maryland. This assessment of local EPH and FPP capacity also offers insight into the strengths and weaknesses of the local food protection and safety infrastructure. Importantly, it reveals an infrastructure and dedicated food protection workforce that inspects the food supply and responds to foodborne illness outbreaks. Yet, resources vary substantially from county to county, impacting which services can be provided and how well they can be performed. This can, in turn, impact the potential risk of foodborne illness and the public's overall health.

Research training of Developmental-Behavioral Pediatrics fellows: a survey of fellowship directors by Developmental-Behavioral Pediatrics Research Network.

PubMed

Wiley, Susan; Schonfeld, David J; Fredstrom, Bridget; Huffman, Lynne

2013-01-01

To describe research training in Developmental-Behavioral Pediatrics (DBP) Fellowship Programs. Thirty-five US-accredited DBP fellowships were contacted through the Developmental-Behavioral Pediatrics Research Network to complete an online survey on scholarly work and research training. With an 83% response rate, responding programs represented 110 (87 filled) fellowship positions. External funding for fellowship positions was minimal (11 positions fully funded, 13 funded above 50% of cost). Structured research training included didactic lectures, web-based training, university courses, direct mentoring, journal clubs, and required reading. Of the 159 fellows described, spanning a 5-year training period, the majority chose projects relying on their own data collection (57%) rather than joining an existing research study and focused on clinical research (86%). Among 96 fellows with completed scholarly work, 29% were observational/epidemiological studies, 22% secondary analyses of large data sets, 16% community-based research, and 15% survey design. A limited number of fellows pursued basic science, meta-analysis/critical appraisal of the literature, or analysis of public policy. Barriers to successful fellow research are as follows: lack of time and money, challenges in balancing clinical demands and protected faculty research time, limited faculty research opportunities, time or expertise, and a lack of infrastructure for fellow research mentoring. The scholarly work of fellows in DBP fellowship programs has primarily focused on clinical research using observational/epidemiological research and secondary analysis of large data set. Barriers largely in faculty time and expertise for research mentoring and inadequate funding in programs that have high clinical demands and little resources for research efforts were noted.

The rise and fall of an opt-out system.

PubMed

Nordfalk, Francisca; Hoeyer, Klaus

2018-04-01

In Denmark, citizens participate in register-based research without the possibility of opting out. However, in 1995 it was made possible for Danish citizens to register an opt-out called 'researcher protection' [ forskerbeskyttelse], which implied that researchers could not contact people to invite them to participate in research projects, such as clinical trials or questionnaries, based on their registrations in national registers. Data already registered could still be used for research. In 2014, this possibility of opt-out was revoked by law. The aims of this paper are to understand how the Danish researcher protection system came about, why it was terminated and what we can we learn from this example. We conducted a descriptive analysis of a copy of the former researcher protection register along with policies and media debate surrounding the rise and revocation of the researcher protection system. Our results show how both the inception and the abolishment of researcher protection appear to be ad hoc and without specified criteria of success. An examination of the recorded entries in the researcher protection registry could have led to changes in its administration as an alternative to its total abolition. In future opt-out systems, there should be focus on monitoring register practices and the purpose and criteria for evaluation must be defined prior to implementation.

Online trust building through third party trust transfer and third party protection

NASA Astrophysics Data System (ADS)

Wandoko, Wanda; Saleh Abbas, Bahtiar; Budiastuti, Dyah; Kosala, Raymond

2017-03-01

The primary objective of this research is to develop an online trust building mechanism for SME (Small Medium Enterprise). Trust is very important in e-commerce. The nature of online shopping has a greater uncertainty than offline shopping. Seeing as there is an uncertainty that can produce risks, a prospective buyer’s trust is needed. A lot of people’s unwillingness to shop online is caused by their lack of trust toward e-commerce. E-commerce is said to be one of the ways for SME to compete with bigger companies. However, building trust requires immense time and cost. SME with limited resources may experience difficulties in building trust just with their own resources. Base on literature research that needs to be validated in next research, we found that trust can be built through trust transfer from the reputable and well-known trust-mark issuer, and third party protection such as escrow account service and credit card issuer.

A Decade of Data Protection for Innovative Drugs in Canada: Issues, Limitations, and Time for a Reassessment

PubMed Central

Kendall, Megan; Hamill, Declan

2016-01-01

Abstract Drug regulators in Canada and in other nations require innovative pharmaceutical companies to submit undisclosed clinical or other data as a condition of approving the marketing of new pharmaceutical products—the origination of which involves considerable effort and investment. Data protection regulations were enacted in Canada in 2006, which—to some extent—closed a loophole in intellectual property law that had previously left innovative companies with no effective data protection for their clinical data. Although the regulations were intended to clarify and effectively implement Canada's international treaty obligations in the spirit of innovation, a review of Canada's first decade of effective data protection shows that Health Canada and Canadian courts have interpreted the scope of data protection for innovative drugs in a narrow manner that undermines and is inconsistent with the intent of the regulations. As the 10-year anniversary of data protection in Canada is this year (2016), this article demonstrates the need to advance Canada's data protection regime into one that consistently contributes to the promotion of investment in pharmaceutical research and development, to the mutual advantage of innovators and patients, in a manner conducive to the social and economic welfare of Canadians. PMID:28077911

A Decade of Data Protection for Innovative Drugs in Canada: Issues, Limitations, and Time for a Reassessment.

PubMed

Kendall, Megan; Hamill, Declan

2016-12-01

Drug regulators in Canada and in other nations require innovative pharmaceutical companies to submit undisclosed clinical or other data as a condition of approving the marketing of new pharmaceutical products-the origination of which involves considerable effort and investment. Data protection regulations were enacted in Canada in 2006, which-to some extent-closed a loophole in intellectual property law that had previously left innovative companies with no effective data protection for their clinical data. Although the regulations were intended to clarify and effectively implement Canada's international treaty obligations in the spirit of innovation, a review of Canada's first decade of effective data protection shows that Health Canada and Canadian courts have interpreted the scope of data protection for innovative drugs in a narrow manner that undermines and is inconsistent with the intent of the regulations. As the 10-year anniversary of data protection in Canada is this year (2016), this article demonstrates the need to advance Canada's data protection regime into one that consistently contributes to the promotion of investment in pharmaceutical research and development, to the mutual advantage of innovators and patients, in a manner conducive to the social and economic welfare of Canadians.

[Internet research methods: advantages and challenges].

PubMed

Liu, Yi; Tien, Yueh-Hsuan

2009-12-01

Compared to traditional research methods, using the Internet to conduct research offers a number of advantages to the researcher, which include increased access to sensitive issues and vulnerable / hidden populations; decreased data entry time requirements; and enhanced data accuracy. However, Internet research also presents certain challenges to the researcher. In this article, the advantages and challenges of Internet research methods are discussed in four principle issue areas: (a) recruitment, (b) data quality, (c) practicality, and (d) ethics. Nursing researchers can overcome problems related to sampling bias and data truthfulness using creative methods; resolve technical problems through collaboration with other disciplines; and protect participant's privacy, confidentiality and data security by maintaining a high level of vigilance. Once such issues have been satisfactorily addressed, the Internet should open a new window for Taiwan nursing research.

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Evaluation and disposition of...

40 CFR 26.1706 - Criteria and procedure for decisions to protect public health by relying on otherwise...

Code of Federal Regulations, 2011 CFR

2011-07-01

... protect public health by relying on otherwise unacceptable research. 26.1706 Section 26.1706 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Ethical Standards for Assessing Whether To Rely on the Results of Human Research in EPA Actions § 26.1706 Criteria and procedure...

40 CFR 26.1706 - Criteria and procedure for decisions to protect public health by relying on otherwise...

Code of Federal Regulations, 2012 CFR

2012-07-01

... protect public health by relying on otherwise unacceptable research. 26.1706 Section 26.1706 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Ethical Standards for Assessing Whether To Rely on the Results of Human Research in EPA Actions § 26.1706 Criteria and procedure...

40 CFR 26.1706 - Criteria and procedure for decisions to protect public health by relying on otherwise...

Code of Federal Regulations, 2010 CFR

2010-07-01

... protect public health by relying on otherwise unacceptable research. 26.1706 Section 26.1706 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Ethical Standards for Assessing Whether To Rely on the Results of Human Research in EPA Actions § 26.1706 Criteria and procedure...

40 CFR 26.1706 - Criteria and procedure for decisions to protect public health by relying on otherwise...

Code of Federal Regulations, 2013 CFR

2013-07-01

... protect public health by relying on otherwise unacceptable research. 26.1706 Section 26.1706 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Standards for Assessing Whether To Rely on the Results of Human Research in EPA Actions § 26.1706 Criteria and procedure for...

40 CFR 26.1706 - Criteria and procedure for decisions to protect public health by relying on otherwise...

Code of Federal Regulations, 2014 CFR

2014-07-01

... protect public health by relying on otherwise unacceptable research. 26.1706 Section 26.1706 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Standards for Assessing Whether To Rely on the Results of Human Research in EPA Actions § 26.1706 Criteria and procedure for...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Evaluation and disposition of... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26...

40 CFR 18.6 - Method of Application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.6 Method of Application. Application for an Environmental Protection Research fellowship shall be made in accordance with... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Method of Application. 18.6 Section 18...

NASA Materials Research for Extreme Conditions

NASA Technical Reports Server (NTRS)

Sharpe, R. J.; Wright, M. D.

2009-01-01

This Technical Memorandum briefly covers various innovations in materials science and development throughout the course of the American Space program. It details each innovation s discovery and development, explains its significance, and describes the applications of this material either in the time period discovered or today. Topics of research include silazane polymers, solvent-resistant elastomeric polymers (polyurethanes and polyisocyanurates), siloxanes, the Space Shuttle thermal protection system, phenolic-impregnated carbon ablator, and carbon nanotubes. Significance of these developments includes the Space Shuttle, Apollo programs, and the Constellation program.

10 CFR 745.103 - Assuring compliance with this policy-research conducted or supported by any Federal department or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROTECTION OF HUMAN SUBJECTS § 745.103 Assuring compliance with this policy—research conducted or supported... file with the Office for Human Research Protections, HHS, or any successor office, and approved for... department and agency heads shall also be made to the Office for Human Research Protections, HHS, or any...

Should Researchers Protect the Good Name and Reputation of Institutions in Which Research Is Done?

ERIC Educational Resources Information Center

Uys, L. R.

2008-01-01

The article explores the issue of protecting the good name and reputation of institutions and organisations in which research is being done. It explores current ethical codes in this regard, as well as legal provision for such protection. The issue of balancing the right of the researchers to share information about institutions in which research…

High-temperature behavior of advanced spacecraft TPS

NASA Technical Reports Server (NTRS)

Pallix, Joan

1994-01-01

The objective of this work has been to develop more efficient, lighter weight, and higher temperature thermal protection systems (TPS) for future reentry space vehicles. The research carried out during this funding period involved the design, analysis, testing, fabrication, and characterization of thermal protection materials to be used on future hypersonic vehicles. This work is important for the prediction of material performance at high temperature and aids in the design of thermal protection systems for a number of programs including programs such as the National Aerospace Plane (NASP), Pegasus and Pegasus/SWERVE, the Comet Rendezvous and Flyby Vehicle (CRAF), and the Mars mission entry vehicles. Research has been performed in two main areas including development and testing of thermal protection systems (TPS) and computational research. A variety of TPS materials and coatings have been developed during this funding period. Ceramic coatings were developed for flexible insulations as well as for low density ceramic insulators. Chemical vapor deposition processes were established for the fabrication of ceramic matrix composites. Experimental testing and characterization of these materials has been carried out in the NASA Ames Research Center Thermophysics Facilities and in the Ames time-of-flight mass spectrometer facility. By means of computation, we have been better able to understand the flow structure and properties of the TPS components and to estimate the aerothermal heating, stress, ablation rate, thermal response, and shape change on the surfaces of TPS. In addition, work for the computational surface thermochemistry project has included modification of existing computer codes and creating new codes to model material response and shape change on atmospheric entry vehicles in a variety of environments (e.g., earth and Mars atmospheres).

High-temperature behavior of advanced spacecraft TPS

NASA Astrophysics Data System (ADS)

Pallix, Joan

1994-05-01

The objective of this work has been to develop more efficient, lighter weight, and higher temperature thermal protection systems (TPS) for future reentry space vehicles. The research carried out during this funding period involved the design, analysis, testing, fabrication, and characterization of thermal protection materials to be used on future hypersonic vehicles. This work is important for the prediction of material performance at high temperature and aids in the design of thermal protection systems for a number of programs including programs such as the National Aerospace Plane (NASP), Pegasus and Pegasus/SWERVE, the Comet Rendezvous and Flyby Vehicle (CRAF), and the Mars mission entry vehicles. Research has been performed in two main areas including development and testing of thermal protection systems (TPS) and computational research. A variety of TPS materials and coatings have been developed during this funding period. Ceramic coatings were developed for flexible insulations as well as for low density ceramic insulators. Chemical vapor deposition processes were established for the fabrication of ceramic matrix composites. Experimental testing and characterization of these materials has been carried out in the NASA Ames Research Center Thermophysics Facilities and in the Ames time-of-flight mass spectrometer facility. By means of computation, we have been better able to understand the flow structure and properties of the TPS components and to estimate the aerothermal heating, stress, ablation rate, thermal response, and shape change on the surfaces of TPS. In addition, work for the computational surface thermochemistry project has included modification of existing computer codes and creating new codes to model material response and shape change on atmospheric entry vehicles in a variety of environments (e.g., earth and Mars atmospheres).

A data recipient centered de-identification method to retain statistical attributes.

PubMed

Gal, Tamas S; Tucker, Thomas C; Gangopadhyay, Aryya; Chen, Zhiyuan

2014-08-01

Privacy has always been a great concern of patients and medical service providers. As a result of the recent advances in information technology and the government's push for the use of Electronic Health Record (EHR) systems, a large amount of medical data is collected and stored electronically. This data needs to be made available for analysis but at the same time patient privacy has to be protected through de-identification. Although biomedical researchers often describe their research plans when they request anonymized data, most existing anonymization methods do not use this information when de-identifying the data. As a result, the anonymized data may not be useful for the planned research project. This paper proposes a data recipient centered approach to tailor the de-identification method based on input from the recipient of the data. We demonstrate our approach through an anonymization project for biomedical researchers with specific goals to improve the utility of the anonymized data for statistical models used for their research project. The selected algorithm improves a privacy protection method called Condensation by Aggarwal et al. Our methods were tested and validated on real cancer surveillance data provided by the Kentucky Cancer Registry. Copyright © 2014 Elsevier Inc. All rights reserved.

100 years of occupational safety research: From basic protections and work analysis to a multilevel view of workplace safety and risk.

PubMed

Hofmann, David A; Burke, Michael J; Zohar, Dov

2017-03-01

Starting with initiatives dating back to the mid-1800s, we provide a high-level review of the key trends and developments in the application of applied psychology to the field of occupational safety. Factory laws, basic worker compensation, and research on accident proneness comprised much of the early work. Thus, early research and practice very much focused on the individual worker, the design of their work, and their basic protection. Gradually and over time, the focus began to navigate further into the organizational context. One of the early efforts to broaden beyond the individual worker was a significant focus on safety-related training during the middle of the 20th century. Toward the latter years of the 20th century and continuing the move from the individual worker to the broader organizational context, there was a significant increase in leadership and organizational climate (safety climate) research. Ultimately, this resulted in the development of a multilevel model of safety culture/climate. After discussing these trends, we identify key conclusions and opportunities for future research. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

45 CFR 46.109 - IRB review of research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.109 IRB review of research. (a) An... judgment the information would meaningfully add to the protection of the rights and welfare of subjects. (c...

Previous Open Rotor Research in the US

NASA Technical Reports Server (NTRS)

VanZante, Dale

2011-01-01

Previous Open Rotor noise experience in the United States, current Open Rotor noise research in the United States and current NASA prediction methods activities were presented at a European Union (EU) X-Noise seminar. The invited attendees from EU industries, research establishments and universities discussed prospects for reducing Open Rotor noise and reviewed all technology programs, past and present, dedicated to Open Rotor engine concepts. This workshop was particularly timely because the Committee on Aviation Environmental Protection (CAEP) plans to involve Independent Experts in late 2011 in assessing the noise of future low-carbon technologies including the open rotor.

Reimagining Human Research Protections for 21st Century Science

PubMed Central

Bietz, Matthew; Bae, Deborah; Bigby, Barbara; Devereaux, Mary; Fowler, James; Waldo, Ann; Weibel, Nadir; Patrick, Kevin; Klemmer, Scott; Melichar, Lori

2016-01-01

Background Evolving research practices and new forms of research enabled by technological advances require a redesigned research oversight system that respects and protects human research participants. Objective Our objective was to generate creative ideas for redesigning our current human research oversight system. Methods A total of 11 researchers and institutional review board (IRB) professionals participated in a January 2015 design thinking workshop to develop ideas for redesigning the IRB system. Results Ideas in 5 major domains were generated. The areas of focus were (1) improving the consent form and process, (2) empowering researchers to protect their participants, (3) creating a system to learn from mistakes, (4) improving IRB efficiency, and (5) facilitating review of research that leverages technological advances. Conclusions We describe the impetus for and results of a design thinking workshop to reimagine a human research protections system that is responsive to 21st century science. PMID:28007687

Analysis characteristics determination of electrohydraulic control system operation to reduce the operation time of a powered roof support

NASA Astrophysics Data System (ADS)

Szurgacz, Dawid

2018-01-01

The article discusses basic functions of a powered roof support in a longwall unit. The support function is to provide safety by protecting mine workings against uncontrolled falling of rocks. The subject of the research includes the measures to shorten the time of roof support shifting. The roof support is adapted to transfer, in hazard conditions of rock mass tremors, dynamic loads caused by mining exploitation. The article presents preliminary research results on the time reduction of the unit advance to increase the extraction process and thus reduce operating costs. Conducted stand tests showed the ability to increase the flow for 3/2-way valve cartridges. The level of fluid flowing through the cartridges is adequate to control individual actuators.

A data protection scheme for medical research networks. Review after five years of operation.

PubMed

Helbing, K; Demiroglu, S Y; Rakebrandt, F; Pommerening, K; Rienhoff, O; Sax, U

2010-01-01

The data protection requirements matured in parallel to new clinical tests generating more personal data since the 1960s. About ten years ago it was recognized that a generic data protection scheme for medical research networks is required, which reinforces patient rights but also allows economically feasible medical research compared to "hand-carved" individual solutions. To give recommendations for more efficient IT infrastructures for medical research networks in compliance with data protection requirements. The IT infrastructures of three medical research networks were reviewed with respect to the relevant data management modules. Recommendations are derived to increase cost efficiency in research networks assessing the consequences of a service provider approach without lowering the data protection level. The existing data protection schemes are very complex. Smaller research networks cannot afford the implementation of such schemes. Larger networks struggle to keep them sustainable. Due to a modular redesign in the medical research network community, a new approach offers opportunities for an efficient sustainable IT infrastructure involving a service provider concept. For standard components 70-80% of the costs could be cut down, for open source components about 37% over a three-year period. Future research networks should switch to a service-oriented approach to achieve a sustainable, cost-efficient IT infrastructure.

National toxicology program review of current DHHS, DOE, and EPA research related to toxicology, fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-11-01

The Annual Plan for the National Toxicology Program requires an annual review of toxicology-related research supported by DHHS agencies. Four of the five Public Health Service Agencies support research related to toxicology. Within the National Institutes of Health alone, sixteen separate institutes and several other components support relevant research. Toxicology-related research is also conducted by other Federal agencies--particularly the Department of Energy (DOE) and the Environmental Protection Agency (EPA). An overall review is thought to be of considerable interest to research managers for purposes of coordinating research and reducing unnecessary duplication. This is the seventeenth review responding to this requirement.more » For the fifteenth time a survey of similar research at DOE and the EPA is included.« less

Building a Governance Strategy for CER: The Patient Outcomes Research to Advance Learning (PORTAL) Network Experience

PubMed Central

Paolino, Andrea R.; McGlynn, Elizabeth A.; Lieu, Tracy; Nelson, Andrew F.; Prausnitz, Stephanie; Horberg, Michael A.; Arterburn, David E.; Gould, Michael K.; Laws, Reesa L.; Steiner, John F.

2016-01-01

Introduction: The Patient Outcomes Research to Advance Learning (PORTAL) Network was established with funding from the Patient-Centered Outcomes Research Institute (PCORI) in 2014. The PORTAL team adapted governance structures and processes from past research network collaborations. We will review and outline the structures and processes of the PORTAL governance approach and describe how proactively focusing on priority areas helped us to facilitate an ambitious research agenda. Background: For years a variety of funders have supported large-scale infrastructure grants to promote the use of clinical datasets to answer important comparative effectiveness research (CER) questions. These awards have provided the impetus for health care systems to join forces in creating clinical data research networks. Often, these scientific networks do not develop governance processes proactively or systematically, and address issues only as problems arise. Even if network leaders and collaborators foresee the need to develop governance approaches, they may underestimate the time and effort required to develop sound processes. The resulting delays can impede research progress. Innovation: Because the PORTAL sites had built trust and a foundation of collaboration by participating with one another in past research networks, essential elements of effective governance such as guiding principles, decision making processes, project governance, data governance, and stakeholders in governance were familiar to PORTAL investigators. This trust and familiarity enabled the network to rapidly prioritize areas that required sound governance approaches: responding to new research opportunities, creating a culture of trust and collaboration, conducting individual studies, within the broader network, assigning responsibility and credit to scientific investigators, sharing data while protecting privacy/security, and allocating resources. The PORTAL Governance Document, complete with a Toolkit of Appendices is included for reference and for adaptation by other networks. Credibility: As a result of identifying project-based governance priorities (IRB approval, subcontracting, selection of new research including lead PI and participating sites, and authorship) and data governance priorities (reciprocal data use agreement, analytic plan procedures, and other tools for data governance), PORTAL established most of its governance structure by Month 6 of the 18 month project. This allowed science to progress and collaborators to experience first-hand how the structures and procedures functioned in the remaining 12 months of the project, leaving ample time to refine them and to develop new structures or processes as necessary. Discussion: The use of procedures and processes with which participating investigators and their home institutions were already familiar allowed project and regulatory requirements to be established quickly to protect patients, their data, and the health care systems that act as stewards for both. As the project progressed, PORTAL was able to test and adjust the structures it put place, and to make substantive revisions by Month 17. As a result, priority processes have been predictable, transparent and effective. Conclusion/Next steps: Strong governance practices are a stewardship responsibility of research networks to justify the trust of patients, health plan members, health care delivery organizations, and other stakeholders. Well-planned governance can reduce the time necessary to initiate the scientific activities of a network, a particular concern when the time frame to complete research is short. Effective network and data governance structures protect patient and institutional data as well as the interests of investigators and their institutions, and assures that the network has built an environment to meet the goals of the research. PMID:27141524

Building a Governance Strategy for CER: The Patient Outcomes Research to Advance Learning (PORTAL) Network Experience.

PubMed

Paolino, Andrea R; McGlynn, Elizabeth A; Lieu, Tracy; Nelson, Andrew F; Prausnitz, Stephanie; Horberg, Michael A; Arterburn, David E; Gould, Michael K; Laws, Reesa L; Steiner, John F

2016-01-01

The Patient Outcomes Research to Advance Learning (PORTAL) Network was established with funding from the Patient-Centered Outcomes Research Institute (PCORI) in 2014. The PORTAL team adapted governance structures and processes from past research network collaborations. We will review and outline the structures and processes of the PORTAL governance approach and describe how proactively focusing on priority areas helped us to facilitate an ambitious research agenda. For years a variety of funders have supported large-scale infrastructure grants to promote the use of clinical datasets to answer important comparative effectiveness research (CER) questions. These awards have provided the impetus for health care systems to join forces in creating clinical data research networks. Often, these scientific networks do not develop governance processes proactively or systematically, and address issues only as problems arise. Even if network leaders and collaborators foresee the need to develop governance approaches, they may underestimate the time and effort required to develop sound processes. The resulting delays can impede research progress. Because the PORTAL sites had built trust and a foundation of collaboration by participating with one another in past research networks, essential elements of effective governance such as guiding principles, decision making processes, project governance, data governance, and stakeholders in governance were familiar to PORTAL investigators. This trust and familiarity enabled the network to rapidly prioritize areas that required sound governance approaches: responding to new research opportunities, creating a culture of trust and collaboration, conducting individual studies, within the broader network, assigning responsibility and credit to scientific investigators, sharing data while protecting privacy/security, and allocating resources. The PORTAL Governance Document, complete with a Toolkit of Appendices is included for reference and for adaptation by other networks. As a result of identifying project-based governance priorities (IRB approval, subcontracting, selection of new research including lead PI and participating sites, and authorship) and data governance priorities (reciprocal data use agreement, analytic plan procedures, and other tools for data governance), PORTAL established most of its governance structure by Month 6 of the 18 month project. This allowed science to progress and collaborators to experience first-hand how the structures and procedures functioned in the remaining 12 months of the project, leaving ample time to refine them and to develop new structures or processes as necessary. The use of procedures and processes with which participating investigators and their home institutions were already familiar allowed project and regulatory requirements to be established quickly to protect patients, their data, and the health care systems that act as stewards for both. As the project progressed, PORTAL was able to test and adjust the structures it put place, and to make substantive revisions by Month 17. As a result, priority processes have been predictable, transparent and effective. Strong governance practices are a stewardship responsibility of research networks to justify the trust of patients, health plan members, health care delivery organizations, and other stakeholders. Well-planned governance can reduce the time necessary to initiate the scientific activities of a network, a particular concern when the time frame to complete research is short. Effective network and data governance structures protect patient and institutional data as well as the interests of investigators and their institutions, and assures that the network has built an environment to meet the goals of the research.

Creation of clinical research databases in the 21st century: a practical algorithm for HIPAA Compliance.

PubMed

Schell, Scott R

2006-02-01

Enforcement of the Health Insurance Portability and Accountability Act (HIPAA) began in April, 2003. Designed as a law mandating health insurance availability when coverage was lost, HIPAA imposed sweeping and broad-reaching protections of patient privacy. These changes dramatically altered clinical research by placing sizeable regulatory burdens upon investigators with threat of severe and costly federal and civil penalties. This report describes development of an algorithmic approach to clinical research database design based upon a central key-shared data (CK-SD) model allowing researchers to easily analyze, distribute, and publish clinical research without disclosure of HIPAA Protected Health Information (PHI). Three clinical database formats (small clinical trial, operating room performance, and genetic microchip array datasets) were modeled using standard structured query language (SQL)-compliant databases. The CK database was created to contain PHI data, whereas a shareable SD database was generated in real-time containing relevant clinical outcome information while protecting PHI items. Small (< 100 records), medium (< 50,000 records), and large (> 10(8) records) model databases were created, and the resultant data models were evaluated in consultation with an HIPAA compliance officer. The SD database models complied fully with HIPAA regulations, and resulting "shared" data could be distributed freely. Unique patient identifiers were not required for treatment or outcome analysis. Age data were resolved to single-integer years, grouping patients aged > 89 years. Admission, discharge, treatment, and follow-up dates were replaced with enrollment year, and follow-up/outcome intervals calculated eliminating original data. Two additional data fields identified as PHI (treating physician and facility) were replaced with integer values, and the original data corresponding to these values were stored in the CK database. Use of the algorithm at the time of database design did not increase cost or design effort. The CK-SD model for clinical database design provides an algorithm for investigators to create, maintain, and share clinical research data compliant with HIPAA regulations. This model is applicable to new projects and large institutional datasets, and should decrease regulatory efforts required for conduct of clinical research. Application of the design algorithm early in the clinical research enterprise does not increase cost or the effort of data collection.

Environmental Research In Practice: Restoration And Protection Of Water Resources

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is tasked to protect human health and the environment. To carry out this task, the EPA makes use of technical expertise within its Office of Research and Development. Restoration and protection of water resources is one area of tec...

40 CFR 26.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2012 CFR

2012-07-01

... intention of involving human subjects. 26.119 Section 26.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human... human subjects. In the event research is undertaken without the intention of involving human subjects...

40 CFR 26.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... intention of involving human subjects. 26.119 Section 26.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human... human subjects. In the event research is undertaken without the intention of involving human subjects...

40 CFR 26.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... intention of involving human subjects. 26.119 Section 26.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human... human subjects. In the event research is undertaken without the intention of involving human subjects...

40 CFR 26.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2014 CFR

2014-07-01

... intention of involving human subjects. 26.119 Section 26.119 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human... human subjects. In the event research is undertaken without the intention of involving human subjects...

34 CFR 97.109 - IRB review of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.109 IRB review... subjects when in the IRB's judgment the information would meaningfully add to the protection of the rights...

The Use of Photo Elicitation to Explore the Benefits of Queer Student Advocacy Groups in University

ERIC Educational Resources Information Center

Joy, Phillip; Numer, Matthew

2017-01-01

University can be a critical time for queer identifying youth as they attempt to navigate new relationships and heteronormative and, sometimes, hostile environments. Involvement in queer student groups is one strategy to develop protective mechanisms for these students. This research examines the effect of participation in a queer advocacy group…

Sustaining visitor use in protected areas: Future opportunities in recreation ecology research based on the USA experience

Treesearch

Christopher A. Monz; David N. Cole; Yu-Fai Leung; Jeffrey L. Marion

2009-01-01

Recreation ecology, the study of environmental consequences of outdoor recreation activities and their effective management, is a relatively new field of scientific study having emerged over the last 50 years. During this time, numerous studies have improved our understanding of how use-related, environmental and managerial factors affect ecological...

After the Bell: Developing Sun Sense--Learning about Protection from the Sun's Rays

ERIC Educational Resources Information Center

Farenga, Stephen J.; Ness, Daniel

2008-01-01

The American Academy of Dermatology (2008) reports that our students will experience 80% of their lifetime exposure to the Sun by the time they are 18. Further, research has demonstrated that continued exposure to the Sun's ultraviolet rays can lead to skin aging, sunburn, immune suppression, ocular melanoma, cataracts, corneal burns, and even…

Do people with intellectual disability require special human subjects research protections? The interplay of history, ethics, and policy.

PubMed

Feudtner, Chris; Brosco, Jeffrey P

2011-01-01

People with intellectual disability (ID) have a long history of discrimination and stigmatization, and a more recent history of pride and self-advocacy. The early history suggests that people with ID are a vulnerable population and deserve special research protections as do some other groups; the disability rights movement of the late 20th century aligns people with ID more closely with the principle of autonomy that has guided clinical and research ethics for the last 40 years. In examining the history of people with ID and the prevailing framework of human subjects research protections in the United States, we conclude that people with ID do not require special protection in human subjects research. The protections that have already been put in place for all individuals, if conscientiously and effectively implemented, achieve the right balance between safeguarding the interest of human research subjects and empowering individuals who choose to do so to participate in research. Copyright © 2012 Wiley Periodicals, Inc.

Research Ethics in the Context of Transition: Gaps in Policies and Programs on the Protection of Research Participants in the Selected Countries of Central and Eastern Europe.

PubMed

Famenka, Andrei

2016-12-01

This paper examines the ability of countries in Central and Eastern Europe (CEE) to ensure appropriate protection of research participants in the field of increasingly globalizing biomedical research. By applying an analytical framework for identifying gaps in policies and programs for human subjects protection to four countries of CEE-Belarus, Latvia, Lithuania, and Poland, substantial gaps in the scope and content of relevant policies and major impediments to program performance have been revealed. In these countries, public policies on the protection of research participants lack consistency and reliable mechanisms for their implementation. Impediments to program performance most often relate to inadequacies in the national research ethics systems with regard to organizational structure, budgetary support, supervision, and training. The level of research ethics capacity varies from country to country and depends on socio-economic and political factors of post-communist transition. The breadth and depth of the problems identified suggest that the current level of protection for research participants in CEE might be inadequate to the challenges posed by the globalization of biomedical research. In CEE countries, there is a need for strengthening research ethics capacity through modification of relevant policies and improvement of program management. The differences among the countries call for further research on identifying the best approaches for filling the gaps in the policies and programs aimed at ensuring effective protection of research participants.

Research ethics in the context of transition: gaps in policies and programs on the protection of research participants in the selected countries of Central and Eastern Europe

PubMed Central

Famenka, Andrei

2015-01-01

This paper examines the ability of countries in Central and Eastern Europe (CEE) to ensure appropriate protection of research participants in the field of increasingly globalizing biomedical research. By applying an analytical framework for identifying gaps in policies and programs for human subjects protection to four countries of CEE – Belarus, Latvia, Lithuania, and Poland, substantial gaps in the scope and content of relevant policies and major impediments to program performance have been revealed. In these countries, public policies on the protection of research participants lack consistency and reliable mechanisms for their implementation. Impediments to program performance most often relate to inadequacies in the national research ethics systems with regard to organizational structure, budgetary support, supervision, and training. The level of research ethics capacity varies from country to country and depends on socio-economic and political factors of post-communist transition. The breadth and depth of the problems identified suggest that the current level of protection for research participants in CEE might be inadequate to the challenges posed by the globalization of biomedical research. In CEE countries, there is a need for strengthening research ethics capacity through modification of relevant policies and improvement of program management. The differences among the countries call for further research on identifying the best approaches for filling the gaps in the policies and programs aimed at ensuring effective protection of research participants. PMID:26548313

34 CFR 97.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... human subjects. 97.119 Section 97.119 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.119 Research undertaken without the intention of involving human...

34 CFR 97.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2013 CFR

2013-07-01

... human subjects. 97.119 Section 97.119 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.119 Research undertaken without the intention of involving human...

34 CFR 97.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... human subjects. 97.119 Section 97.119 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.119 Research undertaken without the intention of involving human...

34 CFR 97.119 - Research undertaken without the intention of involving human subjects.

Code of Federal Regulations, 2014 CFR

2014-07-01

... human subjects. 97.119 Section 97.119 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.119 Research undertaken without the intention of involving human...

78 FR 36783 - Meeting of the Secretary's Advisory Committee on Human Research Protections

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... Research Protections AGENCY: Office of the Assistant Secretary for Health, Office of the Secretary... Advisory Committee Act, U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research Protections (SACHRP) will hold a meeting that will be open to the public...

76 FR 58006 - Meeting of the Secretary's Advisory Committee on Human Research Protections

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

... Research Protections AGENCY: Office of the Assistant Secretary for Health, Office of the Secretary... Advisory Committee Act, U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research Protections (SACHRP) will hold its twenty-sixth meeting. The meeting will be open...

78 FR 56233 - Meeting of the Secretary's Advisory Committee on Human Research Protections

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... Research Protections AGENCY: Office of the Assistant Secretary for Health, Office of the Secretary... Advisory Committee Act, U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research Protections (SACHRP) will hold a meeting that will be open to the public...

'Screening audit' as a quality assurance tool in good clinical practice compliant research environments.

PubMed

Park, Sinyoung; Nam, Chung Mo; Park, Sejung; Noh, Yang Hee; Ahn, Cho Rong; Yu, Wan Sun; Kim, Bo Kyung; Kim, Seung Min; Kim, Jin Seok; Rha, Sun Young

2018-04-25

With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics and human research protection beyond Institutional Review Board approval. Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice (GCP) and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise. Therefore, we developed a simple auditing process (a screening audit) and evaluated its feasibility and effectiveness. The screening audit was developed using a routine audit checklist based on the Severance Hospital's Human Research Protection Program policies and procedures. The measure includes 20 questions, and results are summarized in five categories of audit findings. We analyzed 462 studies that were reviewed by the Severance Hospital Human Research Protection Center between 2013 and 2017. We retrospectively analyzed research characteristics, reply rate, audit findings, associated factors and post-screening audit compliance, etc. RESULTS: Investigator reply rates gradually increased, except for the first year (73% → 26% → 53% → 49% → 55%). The studies were graded as "critical," "major," "minor," and "not a finding" (11.9, 39.0, 42.9, and 6.3%, respectively), based on findings and number of deficiencies. The auditors' decisions showed fair agreement with weighted kappa values of 0.316, 0.339, and 0.373. Low-risk level studies, single center studies, and non-phase clinical research showed more prevalent frequencies of being "major" or "critical" (p = 0.002, < 0.0001, < 0.0001, respectively). Inappropriateness of documents, failure to obtain informed consent, inappropriateness of informed consent process, and failure to protect participants' personal information were associated with higher audit grade (p < 0.0001, p = 0.0001, p < 0.0001, p = 0.003). We were able to observe critical GCP violations in the routine internal audit results of post-screening audit compliance checks in "non-responding" and "critical" studies upon applying the screening audit. Our screening audit is a simple and effective way to assess overall GCP compliance by institutions and to ensure medical ethics. The tool also provides useful selection criteria for conducting routine audits.

Application of Ethical Principles to Research using Public Health Data in The Global South: Perspectives from Africa.

PubMed

Anane-Sarpong, Evelyn; Wangmo, Tenzin; Sankoh, Osman; Tanner, Marcel; Elger, Bernice Simone

2018-06-01

Existing ethics guidelines, influential literature and policies on ethical research generally focus on real-time data collection from humans. They enforce individual rights and liberties, thereby lowering need for aggregate protections. Although dependable, emerging public health research paradigms like research using public health data (RUPD) raise new challenges to their application. Unlike traditional research, RUPD is population-based, aligned to public health activities, and often reliant on pre-collected longitudinal data. These characteristics, when considered in relation to the generally lower protective ethico-legal frameworks of the Global South, including Africa, highlight ethical gaps. Health and demographic surveillance systems are examples of public health programs that accommodate RUPD in these contexts. We set out to explore the perspectives of professionals with a working knowledge of these systems to determine practical ways of appropriating the foundational principles of health research to advance the ever growing opportunities in RUPD. We present their perspectives and in relation to the literature and our ethical analysis, make context relevant recommendations. We further argue for the development of a framework founded on the discussions and recommendations as a minimum base for achieving optimal ethics for optimal RUPD in the Global South. © 2016 John Wiley & Sons Ltd.

The management of heat stress for the firefighter: a review of work conducted on behalf of the Toronto Fire Service.

PubMed

McLellan, Tom M; Selkirk, Glen A

2006-07-01

This report provides a summary of research conducted through a grant provided by the Workplace Safety Insurance Board of Ontario. The research was divided into two phases; first, to define safe work limits for firefighters wearing their protective clothing and working in warm environments; and, the second, to examine strategies to reduce the thermal burden and extend the operational effectiveness of the firefighter. For the first phase, subjects wore their protective ensemble and carried their self-contained breathing apparatus (SCBA) and performed very light, light, moderate or heavy work at 25 degrees C, 30 degrees C or 35 degrees C. Thermal and evaporative resistance coefficients were obtained from thermal manikin testing that allowed the human physiological responses to be compared with modeled data. Predicted continuous work times were then generated using a heat strain model that established limits for increases in body temperature to 38.0 degrees C, 38.5 degrees C and 39.0 degrees C. Three experiments were conducted for the second phase of the project. The first study revealed that replacing the duty uniform pants that are worn under the bunker pants with shorts reduced the thermal strain for activities that lasted longer than 60 min. The second study examined the importance of fluid replacement. The data revealed that fluid replacement equivalent to at least 65% of the sweat lost increased exposure time by 15% compared with no fluid replacement. The last experiment compared active and passive cooling. Both the use of a mister or forearm and hand submersion in cool water significantly increased exposure time compared with passive cooling that involved only removing most of the protective clothing. Forearm and hand submersion proved to be most effective and produced dramatic increases in exposure time that approximated 65% compared with the passive cooling procedure. When the condition of no fluid replacement and passive cooling was compared with fluid replacement and forearm and hand submersion, exposure times were effectively doubled with the latter condition. The heat stress wheel that was generated can be used by Commanders to determine safe work limits for their firefighters during activities that involve wearing their protective clothing and carrying their SCBA.

Hemorrhage Control for Major Traumatic Vascular Injuries

DTIC Science & Technology

2015-10-01

Human Subjects Protection Scientist, at 301-619-9268/karen.m.eaton.ctr@mail.mil. SHARON A. EVANS, PhD, CIP Deputy Director, Human Research... CIP Deputy Director, Human Research Protection Office Office of Research Protections US Army Medical Research and Materiel Command Note: The...debra.depaul.ctr@mail.mil; the POC for the USAMRMC ORP HRPO review is the undersigned at 301-619-7801. 25 ANDREA J. KLINE, MS, CIP Director

Nurse Satisfaction With Opportunities to Engage in Research.

PubMed

Hagan, Joseph

2018-02-01

Nurses should be able to participate in research and integrate evidence from research into practice; however, studies investigating factors related to nurse satisfaction with opportunities to engage in research are lacking. A questionnaire was distributed to nurses employed at two sites: a hospital and a nursing school. Only 16% of nurses reported being satisfied with opportunities to engage in research. In multivariate analysis, degree of belief that resources are a barrier to research was inversely proportional to satisfaction with nursing research opportunities (adjusted odds ratio = 0.13, p < .001), whereas perception that personal relevance is a barrier to research was associated with increased satisfaction (adjusted odds ratio = 2.38, p < .001). Satisfaction with opportunities to engage in research is low. Incentivizing nursing research and providing protected research time, training and education, and mentors to guide nurses through the research process could be effective strategies for increasing satisfaction and research productivity, thereby strengthening evidence-based practice.

The false security of blind dates: chrononymization's lack of impact on data privacy of laboratory data.

PubMed

Cimino, J J

2012-01-01

The reuse of clinical data for research purposes requires methods for the protection of personal privacy. One general approach is the removal of personal identifiers from the data. A frequent part of this anonymization process is the removal of times and dates, which we refer to as "chrononymization." While this step can make the association with identified data (such as public information or a small sample of patient information) more difficult, it comes at a cost to the usefulness of the data for research. We sought to determine whether removal of dates from common laboratory test panels offers any advantage in protecting such data from re-identification. We obtained a set of results for 5.9 million laboratory panels from the National Institutes of Health's (NIH) Biomedical Translational Research Information System (BTRIS), selected a random set of 20,000 panels from the larger source sets, and then identified all matches between the sets. We found that while removal of dates could hinder the re-identification of a single test result, such removal had almost no effect when entire panels were used. Our results suggest that reliance on chrononymization provides a false sense of security for the protection of laboratory test results. As a result of this study, the NIH has chosen to rely on policy solutions, such as strong data use agreements, rather than removal of dates when reusing clinical data for research purposes.

The False Security of Blind Dates

PubMed Central

Cimino, J.J.

2012-01-01

Background The reuse of clinical data for research purposes requires methods for the protection of personal privacy. One general approach is the removal of personal identifiers from the data. A frequent part of this anonymization process is the removal of times and dates, which we refer to as “chrononymization.” While this step can make the association with identified data (such as public information or a small sample of patient information) more difficult, it comes at a cost to the usefulness of the data for research. Objectives We sought to determine whether removal of dates from common laboratory test panels offers any advantage in protecting such data from re-identification. Methods We obtained a set of results for 5.9 million laboratory panels from the National Institutes of Health’s (NIH) Biomedical Translational Research Information System (BTRIS), selected a random set of 20,000 panels from the larger source sets, and then identified all matches between the sets. Results We found that while removal of dates could hinder the re-identification of a single test result, such removal had almost no effect when entire panels were used. Conclusions Our results suggest that reliance on chrononymization provides a false sense of security for the protection of laboratory test results. As a result of this study, the NIH has chosen to rely on policy solutions, such as strong data use agreements, rather than removal of dates when reusing clinical data for research purposes. PMID:23646086

On-Line Thermal Barrier Coating Monitoring for Real-Time Failure Protection and Life Maximization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis H. LeMieux

2004-10-01

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Westinghouse Power Corporation proposes a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization'', to develop, build and install the first generation of an on-line TBC monitoring system for use on land -based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability availability maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCsmore » have been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can therefore accelerate the degradation of substrate components materials and eventually lead to a premature failure of critical component and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Westinghouse Power Corporation has teamed with Indigo Systems; a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization.« less

Advances in on-line drinking water quality monitoring and early warning systems.

PubMed

Storey, Michael V; van der Gaag, Bram; Burns, Brendan P

2011-01-01

Significant advances have been made in recent years in technologies to monitor drinking water quality for source water protection, treatment operations, and distribution system management, in the event of accidental (or deliberate) contamination. Reports prepared through the Global Water Research Coalition (GWRC) and United States Environment Protection Agency (USEPA) agree that while many emerging technologies show promise, they are still some years from being deployed on a large scale. Further underpinning their viability is a need to interpret data in real time and implement a management strategy in response. This review presents the findings of an international study into the state of the art in this field. These results are based on visits to leading water utilities, research organisations and technology providers throughout Europe, the United States and Singapore involved in the development and deployment of on-line monitoring technology for the detection of contaminants in water. Copyright © 2010 Elsevier Ltd. All rights reserved.

The evaluation of trifloxystrobin in protection of Calendula officinalis (Pot marigold) against Erysiphe cichoracearum DC.

PubMed

Kurzawińska, H; Duda-Surman, J

2006-01-01

The aim of the two-years field's examinations was the evaluation of the fungicide Zato 50 WG (biologically active substances BAS--trifloxystrobin 50%) in protection of Calendula officinalis (Pot marigold) against Erysiphe cichoracearum. Mentioned fungicide was applied at three concentrations: 0.1, 0.15 and 0.2%. As the standard fungicide Amistar 250 SC (biologically active substances BAS - azoxystrobin 250 g/dm3) was used. In every year of research work the four protective treatments were carried out. The estimation of infestation degree of Calendula officinalis leafs by the Erysiphe cichoracearum was made 5 times. Before each treatment four analysis were done, whereas the last analysis--the fifth one was executed after 10 days from the last protective spraying. According to the results, it was found that investigated preparations significant reduced the mean infestation degree of Calendula officinalis leafs by the Erysiphe cichoracearum compared to the control. The results pointed, that in protection of the mentioned plant by the powdery mildew the 0.2% dose of Zato 50WG showed the best suitability.

Cost estimates for flood resilience and protection strategies in New York City.

PubMed

Aerts, Jeroen C J H; Botzen, W J Wouter; de Moel, Hans; Bowman, Malcolm

2013-08-01

In the aftermaths of Hurricanes Irene, in 2011, and Sandy, in 2012, New York City has come to recognize the critical need to better prepare for future storm surges and to anticipate future trends, such as climate change and socio-economic developments. The research presented in this report assesses the costs of six different flood management strategies to anticipate long-term challenges the City will face. The proposed strategies vary from increasing resilience by upgrading building codes and introducing small scale protection measures, to creating green infrastructure as buffer zones and large protective engineering works such as storm surge barriers. The initial investment costs of alternative strategies vary between $11.6 and $23.8 bn, maximally. We show that a hybrid solution, combining protection of critical infrastructure and resilience measures that can be upgraded over time, is less expensive. However, with increasing risk in the future, storm surge barriers may become cost-effective, as they can provide protection to the largest areas in both New York and New Jersey. © 2013 New York Academy of Sciences.

Lightning research: A user's lament

NASA Technical Reports Server (NTRS)

Golub, C. N.

1984-01-01

As a user of devices and procedures for lightning protection, the author is asking the lightning research community for cookbook recipes to help him solve his problems. He is lamenting that realistic devices are scarce and that his mission does not allow him the time nor the wherewithal to bridge the gap between research and applications. A few case histories are presented. In return for their help he is offering researchers a key to lightning technology--the use of the Eastern Test Range and its extensive resources as a proving ground for their experiment in the lightning capital of the United States. A current example is given--a joint lightning characterization project to take place there. Typical resources are listed.

One-eyed science: scientists, workplace reproductive hazards, and the right to work.

PubMed

Messing, K

1999-01-01

Although most occupational health research has been done with male subjects and on jobs traditionally done by men, research on reproductive hazards is an exception. Researchers were late to realize that men were exposed to reproductive hazards. However, women's health problems have been excluded from the large scientific literature on reproductive hazards, which has concentrated on hazards to fetuses. This is true even of much feminist-oriented research. This neglect is attributable to a reluctance to emphasize health hazards for women at work, since identifying those specific to women may militate against women's employment. Union action is in fact necessary to protect access to employment and health at the same time.

Outcome of the European initiative for radiation protection research and future perspectives.

PubMed

Repussard, J

2018-01-01

In 2009, the European Commission published the report of the high-level expert group that had been mandated to consider the scientific challenges posed by the issues of low dose effects of ionising radiation, and to formulate proposals for research policy evolution in this field at European level. This report formulated a first draft of a strategic research agenda. International scientific cooperation and an integrated approach are essential for the further development and enhancement of the international framework of radiation protection. This paper reflects on the results which have been gained through this integration approach: strategic research agendas have been established, policies and action plans have been developed for infrastructures and training education, several ambitious research projects have been launched, and a first draft of a European 'joint road map' for radiation protection research will be published. Reflecting on the challenges that lie ahead, this paper also presents the initiatives that the five European research platforms (MELODI: low dose research; ALLIANCE: radioecology; EURADOS: dosimetry; NERIS: emergency preparedness; EURAMED: radiation protection in medical applications) have jointly presented to the European Commission and Euratom member states to further enhance radiation protection research.

Using Facebook for Health-related Research Study Recruitment and Program Delivery

PubMed Central

Pedersen, Eric R.; Kurz, Jeremy

2015-01-01

Facebook has become an important tool for recruiting research participants and for program delivery. Given the wide use of Facebook, there is much potential for the site to help with recruitment efforts in both physical and behavioral health care arenas; reaching groups typically difficult to recruit and providing outreach to individuals that may not have received services elsewhere. Health studies using Facebook have generally reported success, including cost-effectiveness, recruitment of samples in brief periods of time, and ability to locate participants for follow-up research. Still, the use of Facebook for research and program delivery is a relatively new area that warrants more research attention and guidance around issues like validity of data, representativeness of samples, and protections of human subjects. PMID:26726313

Using Facebook for Health-related Research Study Recruitment and Program Delivery.

PubMed

Pedersen, Eric R; Kurz, Jeremy

2016-05-01

Facebook has become an important tool for recruiting research participants and for program delivery. Given the wide use of Facebook, there is much potential for the site to help with recruitment efforts in both physical and behavioral health care arenas; reaching groups typically difficult to recruit and providing outreach to individuals that may not have received services elsewhere. Health studies using Facebook have generally reported success, including cost-effectiveness, recruitment of samples in brief periods of time, and ability to locate participants for follow-up research. Still, the use of Facebook for research and program delivery is a relatively new area that warrants more research attention and guidance around issues like validity of data, representativeness of samples, and protections of human subjects.

Protections for Subjects in Human Research with Pesticides

EPA Pesticide Factsheets

All pesticide research using human subjects must meet our strict protective standards before we would consider using them in evaluating pesticides. EPA's regulation “Protections for Subjects in Human Research” was promulgated in 2006 and amended in 2013.

E-recruitment based clinical research: notes for Research Ethics Committees/Institutional Review Boards.

PubMed

Refolo, P; Sacchini, D; Minacori, R; Daloiso, V; Spagnolo, A G

2015-01-01

Patient recruitment is a critical point of today's clinical research. Several proposals have been made for improving it, but the effectiveness of these measures is actually uncertain. The use of Internet (e-recruitment) could represent a great chance to improve patient enrolment, even though the effectiveness of this implementation is not so evident. E-recruitment could bring some advantages, such as better interaction between clinical research demand and clinical research supply, time and resources optimization, and reduction of data entry errors. It raises some issues too, such as sampling errors, validity of informed consent, and protection of privacy. Research Ethics Committees/Institutional Review Boards should consider these critical points. The paper deals with Internet recruitment for clinical research. It also attempts to provide Research Ethics Committees/Institutional Review Boards with notes for assessing e-recruitment based clinical protocols.

Legal and ethical issues in neuroimaging research: human subjects protection, medical privacy, and the public communication of research results.

PubMed

Kulynych, Jennifer

2002-12-01

Humans subjects research entails significant legal and ethical obligations. Neuroimaging researchers must be familiar with the requirements of human subjects protection, including evolving standards for the protection of privacy and the disclosure of risk in "non-therapeutic" research. Techniques for creating veridical surface renderings from volumetric anatomical imaging data raise new privacy concerns, particularly under the federal medical privacy regulation. Additionally, neuroimaging researchers must consider their obligation to communicate research results responsibly. The emerging field of neuroethics should strive to raise awareness of these issues and to involve neuroimaging researchers in the legal, ethical, and policy debates that currently surround human subjects research.

Are Risky Youth Less Protectable As They Age? The Dynamics of Protection During Adolescence and Young Adulthood

PubMed Central

Krohn, Marvin D.; Lizotte, Alan J.; Phillips, Matthew D.; Schmidt, Nicole M.

2013-01-01

Research on recidivism in criminal justice and desistance in criminology are not integrated. Yet, both fields seem to be moving towards models that look at how positive elements in a person's environment can impact a person's behavior, conditional on different levels of risk. This study builds on this observation by applying interactional theory and the concept of Risk-Needs-Responsivity to theorize that both Needs and Responsivity will change over time in predictable ways. We then use a novel empirical approach with the Rochester Youth Development Study to show that even in late adolescence, individuals who are at risk for violence can be protected from future violence and risky behavior like gun carrying with positive events in their environment and personal life. In young adulthood, fewer people are still at risk for violence, and those who are at risk are harder to protect from future violence and gun carrying. PMID:24363492

Mechanical evaluation of hip pads to protect against fracture of elderly femurs in falls.

PubMed

Tadano, Shigeru; Nakatsuchi, Hiroki; Goto, Naoko; Fujisaki, Kazuhiro; Nakatsuchi, Yukio

2011-01-01

Hip fracture in the aged easily occurs by falls and may cause these persons to become bedridden. Hip pads are effective in protecting hip fracture as they directly deflect and absorb the impact forces by falls. It is necessary for the material and the structure of hip pads to be designed to realize both high impact absorption and compliance (comfort during wearing). In this report, an impact testing system was developed to test the impact absorbing performance of hip pad with air cushions designed by the research group. The impact absorbing performance was evaluated by the impact load, collision time, and maximum load. To confirm the effectiveness in protecting against hip fracture, an impact force was applied to the greater trochanter of the human femur and the degree of fracture was measured by X-ray examination. As a result, the hip pad with air cushions had a high impact absorbing performance and was sufficiently effective to protect against hip fracture.

Time perspective and attitude-behaviour consistency in future-oriented behaviours.

PubMed

Rabinovich, Anna; Morton, Thomas; Postmes, Tom

2010-03-01

The authors propose that the salience of a distant-future time perspective, compared to a near-future time perspective, should increase attitude-behaviour and attitude-intention consistency for future-oriented behaviours. To test this prediction, time perspective was experimentally manipulated in three studies. Across studies, participants in the distant-future time perspective condition demonstrated a strong positive relationship between attitudes towards future-oriented behaviours (saving and environmental protection) and corresponding intentions, as well as between attitudes and behaviour. In the near-future time perspective condition, the relationship between attitudes and intentions and attitudes and behaviour was significantly weaker than in the distant-future time perspective condition. The theoretical implications of these results and suggestions for future research are discussed.

Assessment of Brazil’s Research Literature

DTIC Science & Technology

2007-09-28

Autonomously interconnecting with real-time monitoring • Secure, survivable, self - healing , and adaptable • Resistant to jamming • Homeland and... self - healing platforms • Force Protection • Anti-swimmer technology • Detect and determine threat intent • Non-lethal response Associated CV...Brazilian strengths in chemistry and several industrially oriented R&D domains. We apply text clustering to obtain “ self -organizing tables of

The Role of Riparian Vegetation in Protecting and Improving Chemical Water Quality in Streams

Treesearch

Michael G. Dosskey; Philippe Vidon; Noel P. Gurwick; Craig J. Allan; Tim P. Duval; Richard Lowrance

2010-01-01

We review the research literature and summarize the major processes by which riparian vegetation influences chemical water quality in streams, as well as how these processes vary among vegetation types, and discuss how these processes respond to removal and restoration of riparian vegetation and thereby determine the timing and level of response in stream water quality...

78 FR 58574 - Maintenance, Testing, and Replacement of Vented Lead-Acid Storage Batteries for Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... time that a document is referenced. Revision 3 of Regulatory Guide 1.129 is available in ADAMS under...-251-7455; email: [email protected] . Both of the Office of Nuclear Regulatory Research, U.S... NRC is issuing a revision to an existing guide in the NRC's ``Regulatory Guide'' series. This series...

Beyond Concern: K-12 Faculty and Staff's Perspectives on Privacy Topics and Cybersafety

ERIC Educational Resources Information Center

Hipsky, Shellie; Younes, Wiam

2015-01-01

In a time when discussions about information privacy dominate the media, research on Cybersafety education reveals that K-12 teachers and staff are concerned about information privacy in schools and they seek to learn more about the protection of their students' and own personal information online. Privacy topics are typically introduced to the…

Evaluating the impact on practice of a west of Berkshire protected learning time initiative in primary care.

PubMed

Stenner, Karen; Iacovou, Nicci

2006-01-01

WHAT IS ALREADY KNOWN IN THIS AREA • Research indicates that Protected Learning Time (PLT) events in primary care enable professionals to network and share ideas. • A variety of educational techniques have been shown to improve performance of: individual practitioners in other settings. • Beyond one-off examples, there is little published evidence that PLT helps to improve practice. WHAT THIS WORK ADDS • It describes a range of ways in which PLT has impacted on practice at the level of the individual, the team and the wider organisation. • It highlights the main benefits of large event PLT according to participants at a Berkshire initiative. The benefits include increased awareness of services, increased understanding of illnesses and improved treatment. SUGGESTIONS FOR FUTURE RESEARCH • Do large PLT events have different outcomes from practice-based PLT? • How does PLT impact on the development of a learning culture? • How can large; learning events best meet the needs of different groups of professionals? • What impact, if any, does the closure of surgeries for PLT have on use of out-of-hours services or subsequent workload?

Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies.

PubMed

Christou, Helen; Dizon, Maria L V; Farrow, Kathryn N; Jadcherla, Sudarshan R; Leeman, Kristen T; Maheshwari, Akhil; Rubin, Lewis P; Stansfield, Brian K; Rowitch, David H

2016-11-01

Understanding mechanisms of childhood disease and development of rational therapeutics are fundamental to progress in pediatric intensive care specialties. However, Division Chiefs and Department Chairs face unique challenges when building effective laboratory-based research programs in Neonatal and Pediatric Intensive Care, owing to high clinical demands necessary to maintain competence as well as financial pressures arising from fund flow models and the current extramural funding climate. Given these factors, the role of institutional support that could facilitate successful transition of promising junior faculty to independent research careers is ever more important. Would standardized guidelines of such support provide greater consistency among institutions? We addressed preliminary questions during a national focus group, a workshop and a survey of junior and senior academicians to solicit recommendations for optimal levels of protected time and resources when starting an independent laboratory. The consensus was that junior faculty should be assigned no more than 8 wk clinical service and should obtain start-up funds of $500K-1M exclusive of a 5-y committed salary support. Senior respondents placed a higher premium on protected time than junior faculty.

Research culture and capacity in community health services: results of a structured survey of staff.

PubMed

Friesen, Emma L; Comino, Elizabeth J

2017-05-01

Developing research capacity is recognised as an important endeavour. However, little is known about the current research culture, capacity and supports for staff working in community-based health settings. A structured survey of Division of Community Health staff was conducted using the research capacity tool. The survey was disseminated by email and in paper format. Quantitative data were analysed using descriptive statistics. Qualitative data were analysed thematically. In total, 109 usable responses were received, giving a response rate of 26%. Respondents were predominately nurses (n=71, 65.7%), with ~50% reporting post-graduate vocational qualifications. The highest levels of skills or organisational success were in using evidence to plan, promote and guide clinical practice. Most participants were unsure of organisational and team level skills and success at generating research. Few reported recent experience in research-generating activities. Barriers to undertaking research included lack of skills, time and access to external support and funding. Lack of skills and success in accessing external funding and resources to protect research time or to 'buy-in' technical expertise appeared to exacerbate these barriers. Community health staff have limited capacity to generate research with current levels of skill, funding and time. Strategies to increase research capacity should be informed by knowledge of clinicians' research experience and interests, and target development of skills to generate research. Resources and funding are needed at the organisational and team levels to overcome the significant barriers to research generation reported.

History of Plant Phenological Observation in Hungary and Plans for Renewal of System to detect Evidence of the Climate Change

NASA Astrophysics Data System (ADS)

Hunkar, M.; Dunkel, Z.

2009-04-01

The first plant protection warning was issued 1760 by the Senate of the Town of Debrecen concerning the destruction of caterpillar's nest. In the middle of the 19th century the first responsible Hungarian Government issued a note in which the minister takes measurements for the phytosanitary safety of agricultural products. Though Hungary had not got independent institutional system for plant protection at the end of the 19th c., still in the middle of the 1870s, the territory of the country was protected with harmonised quarantine measures from the introduction of Colorado beetle. A new era started both in Europe and in Hungary with the devastation caused by Phylloxera vastatrix in vineyards. In 1876, the Act 29 definitely specified the measures to be taken for preventing the spread of the pest and the damages caused by it; and it was proclaimed in both Chambers of the Parliament. This incident resulted basically in the launching for the establishment of an independent plant protection institution. In l880, the National Committee on Phylloxera, then in 1881, the National Experimental Station for Phylloxera was set up, this latter considered as the first nucleus of the Hungarian plant protection organisation. The international plant protection convention, concluded in 1929 and signed by our country, had a great role in the history of the development of the plant protection organisation. Hungary agreed to establish an official plant protection organization which should consist of a plant protection service and a research institute. In compliance with the Ministerial Decree 49.000/1932 the Hungarian Plant Protection Service was set up which can now be taken for the first organisation of the uniform national plant protection administration system. Plant protection stations were established in 1954. The plant phenological observation network was run by the plant protection administration but financially was maintained by OMSZ therefore the main aim of the phenological observation in Hungary is to give information for plant protection forecast. The system was time to time renewed, last tin in 1984. The system was closed in 2001because of financial restriction. Taking into consideration of necessity of systematic phenological observation mainly as a possible tool of climate change detection and seeing the results of COST Action 725 a project proposal was submitted for reconstruction of phonological network. Beside the main historical milestones of Hungarian phenological history the most important elements of the new plan will be shown. Since climate change expressed by the responses of the vegetation system our investigation is focused to long time data series like the Book of Vine Branches which contains the conditions of wine branches year by year on St. George day 24 April since 1740.

No One Likes a Snitch.

PubMed

Redman, Barbara; Caplan, Arthur

2015-08-01

Whistleblowers remain essential as complainants in allegations of research misconduct. Frequently internal to the research team, they are poorly protected from acts of retribution, which may deter the reporting of misconduct. In order to perform their important role, whistleblowers must be treated fairly. Draft regulations for whistleblower protection were published for public comment almost a decade ago but never issued (Dahlberg 2013). In the face of the growing challenge of research fraud, we suggest vigorous steps, to include: organizational responsibility to certify the accuracy of research including audit, required whistleblower action in the face of imminent or grave harm to subjects, strengthened legal protections against retaliation including prompt enactment of Federal whistleblower protections and consideration of criminalizing the most egregious cases of research misconduct.

Certificates of confidentiality: legal counsels' experiences with and perspectives on legal demands for research data.

PubMed

Wolf, Leslie E; Dame, Lauren A; Patel, Mayank J; Williams, Brett A; Austin, Jefferey A; Beskow, Laura M

2012-10-01

The certificate of confidentiality (Certificate) is an important tool for protecting identifiable, sensitive human subjects research data in the United States. However, little is known about the Certificate's effectiveness in protecting identifiable data. We interviewed 24 legal counsel representing U.S. research institutions about their experiences with legal demands for research data. Our respondents reported few, if any, legal demands over the course of their tenure, but two-thirds had experience with legal demands for data protected by a Certificate. They reported such demands often were resolved without disclosure of identifiable research data, typically without court intervention. While our respondents reported similar success protecting identifiable data in court, they often did not rely on the Certificate to do so.

40 CFR 26.1102 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non... service programs may include research activities. (e) Human subject means a living individual about whom...

Precise time and time interval applications to electric power systems

NASA Technical Reports Server (NTRS)

Wilson, Robert E.

1992-01-01

There are many applications of precise time and time interval (frequency) in operating modern electric power systems. Many generators and customer loads are operated in parallel. The reliable transfer of electrical power to the consumer partly depends on measuring power system frequency consistently in many locations. The internal oscillators in the widely dispersed frequency measuring units must be syntonized. Elaborate protection and control systems guard the high voltage equipment from short and open circuits. For the highest reliability of electric service, engineers need to study all control system operations. Precise timekeeping networks aid in the analysis of power system operations by synchronizing the clocks on recording instruments. Utility engineers want to reproduce events that caused loss of service to customers. Precise timekeeping networks can synchronize protective relay test-sets. For dependable electrical service, all generators and large motors must remain close to speed synchronism. The stable response of a power system to perturbations is critical to continuity of electrical service. Research shows that measurement of the power system state vector can aid in the monitoring and control of system stability. If power system operators know that a lightning storm is approaching a critical transmission line or transformer, they can modify operating strategies. Knowledge of the location of a short circuit fault can speed the re-energizing of a transmission line. One fault location technique requires clocks synchronized to one microsecond. Current research seeks to find out if one microsecond timekeeping can aid and improve power system control and operation.

Lithium-ion Battery Demonstration for the 2007 NASA Desert Research and Technology Studies (Desert RATS) Program

NASA Technical Reports Server (NTRS)

Bennett, William; Baldwin, Richard

2007-01-01

The NASA Glenn Research Center (GRC) Electrochemistry Branch designed and produced five lithium-ion battery packs for demonstration in a portable life support system (PLSS) on spacesuit simulators. The experimental batteries incorporated advanced, NASA-developed electrolytes and included internal protection against over-current, over-discharge and over-temperature. The 500-gram batteries were designed to deliver a constant power of 38 watts over 103 minutes of discharge time (130 Wh/kg). Battery design details are described and field and laboratory test results are summarized.

Sensitive Interviewing in Qualitative Research.

PubMed

Dempsey, Laura; Dowling, Maura; Larkin, Philip; Murphy, Kathy

2016-12-01

In this paper we focus on important considerations when planning and conducting qualitative interviews on sensitive topics. Drawing on experiences of conducting interviews with dementia caregivers, a framework of essential elements in qualitative interviewing was developed to emphasize study participants' needs while also providing guidance for researchers. Starting with a definition of sensitive research, the framework includes preparing for interviews, interacting with gatekeepers of vulnerable groups, planning for interview timing, and location, building relationships and conducting therapeutic interactions, protecting ethically vulnerable participants, and planning for disengagement. This framework has the potential to improve the effectiveness of sensitive interviewing with vulnerable groups. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Protecting Privacy and Confidentiality in Environmental Health Research.

PubMed

Resnik, David B

2010-01-01

Environmental health researchers often need to make difficult decisions on how to protect privacy and confidentiality when they conduct research in the home or workplace. These dilemmas are different from those normally encountered in clinical research. Although protecting privacy and confidentiality is one of the most important principles of research involving human subjects, it can be overridden to prevent imminent harm to individuals or if required by law. Investigators should carefully consider the facts and circumstances and use good judgment when deciding whether to breach privacy or confidentiality.

Risk and Protective Factors in the Lives of Transgender/Gender Nonconforming Adolescents.

PubMed

Eisenberg, Marla E; Gower, Amy L; McMorris, Barbara J; Rider, G Nicole; Shea, Glynis; Coleman, Eli

2017-10-01

Research suggests that transgender and gender nonconforming (TGNC) youth may be at greatly increased risk of high-risk health behaviors compared with cisgender youth, but existing studies are limited by convenience samples and small numbers. This study uses a large school-based sample of adolescents to describe the prevalence of TGNC identity, associations with health risk behaviors and protective factors, and differences across birth-assigned sex. This study analyzes existing surveillance data provided by 9th and 11th grade students in Minnesota in 2016 (N = 81,885). Students who were transgender, genderqueer, genderfluid, or unsure about their gender identity (TGNC) were compared with those who were not, using χ 2 and t-tests. Outcome measures included four domains of high-risk behaviors and experiences and four protective factors. The prevalence of TGNC identity was 2.7% (n = 2,168) and varied significantly across gender, race/ethnicity, and economic indicators. Involvement in all types of risk behaviors and experiences was significantly higher, and reports of four protective factors were significantly lower among TGNC than cisgender youth. For example, almost two-thirds (61.3%) of TGNC youth reported suicidal ideation, which is over three times higher than cisgender youth (20.0%, χ 2  = 1959.9, p < .001). Among TGNC youth, emotional distress and bullying experience were significantly more common among birth-assigned females than males. This research presents the first large-scale, population-based evidence of substantial health disparities for TGNC adolescents in the United States, highlighting numerous multilevel points of intervention through established protective factors. Health care providers are advised to act as allies by creating a safe space for young people, bolstering protective factors, and supporting their healthy development. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Describing Maltreatment: Do Child Protective Service Reports and Research Definitions Agree?

ERIC Educational Resources Information Center

Runyan, Desmond K.; Cox, Christine E.; Dubowitz, Howard; Newton, Rae R.; Upadhyaya, Mukund; Kotch, Jonathan B.; Leeb, Rebecca T.; Everson, Mark D.; Knight, Elizabeth D.

2005-01-01

Objective: The National Research Council identified inadequate research definitions for abuse and neglect as barriers to research in child maltreatment. We examine the concordance between child protective services (CPS) classifications of maltreatment type with the determinations of type from two research coding systems. We contrast the two coding…

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

40 CFR 26.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Cooperative research. 26.114 Section 26... Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve...

40 CFR 26.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Cooperative research. 26.114 Section 26... Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

40 CFR 26.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Cooperative research. 26.114 Section 26... Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve...

40 CFR 26.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Cooperative research. 26.114 Section 26... Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

40 CFR 26.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Cooperative research. 26.114 Section 26... Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve...

"Snow White" Coating Protects SpaceX Dragon's Trunk Against Rigors of Space

NASA Technical Reports Server (NTRS)

McMahan, Tracy

2013-01-01

He described it as "snow white." But NASA astronaut Don Pettit was not referring to the popular children's fairy tale. Rather, he was talking about the white coating of the Space Exploration Technologies Corp. (SpaceX) Dragon spacecraft that reflected from the International Space Station s light. As it approached the station for the first time in May 2012, the Dragon s trunk might have been described as the "fairest of them all," for its pristine coating, allowing Pettit to clearly see to maneuver the robotic arm to grab the Dragon for a successful nighttime berthing. This protective thermal control coating, developed by Alion Science and Technology Corp., based in McLean, Va., made its bright appearance again with the March 1 launch of SpaceX's second commercial resupply mission. Named Z-93C55, the coating was applied to the cargo portion of the Dragon to protect it from the rigors of space. "For decades, Alion has produced coatings to protect against the rigors of space," said Michael Kenny, senior chemist with Alion. "As space missions evolved, there was a growing need to dissipate electrical charges that build up on the exteriors of spacecraft, or there could be damage to the spacecraft s electronics. Alion's research led us to develop materials that would meet this goal while also providing thermal controls. The outcome of this research was Alion's proprietary Z-93C55 coating."

Nation-wide primary healthcare research network: a privacy protection assessment.

PubMed

De Clercq, Etienne; Van Casteren, Viviane; Bossuyt, Nathalie; Moreels, Sarah; Goderis, Geert; Bartholomeeusen, Stefaan; Bonte, Pierre; Bangels, Marc

2012-01-01

Efficiency and privacy protection are essential when setting up nationwide research networks. This paper investigates the extent to which basic services developed to support the provision of care can be re-used, whilst preserving an acceptable privacy protection level, within a large Belgian primary care research network. The generic sustainable confidentiality management model used to assess the privacy protection level of the selected network architecture is described. A short analysis of the current architecture is provided. Our generic model could also be used in other countries.

THE ENVIRONMENTAL PROTECTION AGENCY'S WATERSHED MANAGEMENT RESEARCH PROGRAM: AN OVERVIEW

EPA Science Inventory

The Environmental Protection Agency (EPA) has directed much attention to watersheds and water quality during its tenure as the United States Federal Agency charged with protection of human health and the environment. Watershed research as a vehicle to understand the interaction ...

40 CFR 1400.12 - Qualified researchers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Qualified researchers. 1400.12 Section 1400.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY AND DEPARTMENT OF JUSTICE ACCIDENTAL RELEASE PREVENTION REQUIREMENTS; RISK MANAGEMENT PROGRAMS UNDER THE CLEAN AIR ACT SECTION 112(r)(7...

Teamwork and team decision-making at multidisciplinary cancer conferences: barriers, facilitators, and opportunities for improvement.

PubMed

Lamb, Benjamin W; Sevdalis, Nick; Arora, Sonal; Pinto, Anna; Vincent, Charles; Green, James S A

2011-09-01

Anecdotally, multidisciplinary cancer conferences (MCCs) do not always function optimally. MCC members' experiences with and attitudes toward MCCs are explored, and barriers to and facilitators of effective team-working are identified. A total of 19 semistructured interviews were conducted with surgeons, oncologists, nurses, and administrators. Interviews explored participants' opinions on MCC attendance, information presentation, case discussion, leadership, team decision-making, and possible improvements to MCC meetings. Nonattendance was associated with not having protected time to attend the MCC. Contributions to MCC discussions were unequal among the participants, and patient-centered information was ignored. Good leadership was necessary to foster inclusive case discussion. Members were positive about MCCs, but protected time, improved case selection, and working in a more structured way were possible improvements. Results are consistent with previous research: Members of the MCC are positive about the benefits of MCCs, although improving the way MCCs work is a goal.

Reimagining Human Research Protections for 21st Century Science.

PubMed

Bloss, Cinnamon; Nebeker, Camille; Bietz, Matthew; Bae, Deborah; Bigby, Barbara; Devereaux, Mary; Fowler, James; Waldo, Ann; Weibel, Nadir; Patrick, Kevin; Klemmer, Scott; Melichar, Lori

2016-12-22

Evolving research practices and new forms of research enabled by technological advances require a redesigned research oversight system that respects and protects human research participants. Our objective was to generate creative ideas for redesigning our current human research oversight system. A total of 11 researchers and institutional review board (IRB) professionals participated in a January 2015 design thinking workshop to develop ideas for redesigning the IRB system. Ideas in 5 major domains were generated. The areas of focus were (1) improving the consent form and process, (2) empowering researchers to protect their participants, (3) creating a system to learn from mistakes, (4) improving IRB efficiency, and (5) facilitating review of research that leverages technological advances. We describe the impetus for and results of a design thinking workshop to reimagine a human research protections system that is responsive to 21st century science. ©Cinnamon Bloss, Camille Nebeker, Matthew Bietz, Deborah Bae, Barbara Bigby, Mary Devereaux, James Fowler, Ann Waldo, Nadir Weibel, Kevin Patrick, Scott Klemmer, Lori Melichar. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 22.12.2016.

Watershed monitoring and modelling and USA regulatory compliance.

PubMed

Turner, B G; Boner, M C

2004-01-01

The aim of the Columbus program was to implement a comprehensive watershed monitoring-network including water chemistry, aquatic biology and alternative sensors to establish water environment health and methods for determining future restoration progress and early warning for protection of drinking water supplies. The program was implemented to comply with USA regulatory requirements including Total Maximum Daily Load (TMDL) rules of the Clean Water Act (CWA) and Source Water Assessment and Protection (SWAP) rules under the Safe Drinking Water Act (SDWA). The USEPA Office of Research and Development and the Water Environment Research Foundation provided quality assurance oversight. The results obtained demonstrated that significant wet weather data is necessary to establish relationships between land use, water chemistry, aquatic biology and sensor data. These measurements and relationships formed the basis for calibrating the US EPA BASINS Model, prioritizing watershed health and determination of compliance with water quality standards. Conclusions specify priorities of cost-effective drainage system controls that attenuate stormwater flows and capture flushed pollutants. A network of permanent long-term real-time monitoring using combination of continuous sensor measurements, water column sampling and aquatic biology surveys and a regional organization is prescribed to protect drinking water supplies and measure progress towards water quality targets.

Grand Canyon Monitoring and Research Center

USGS Publications Warehouse

Hamill, John F.

2009-01-01

The Grand Canyon of the Colorado River, one of the world's most spectacular gorges, is a premier U.S. National Park and a World Heritage Site. The canyon supports a diverse array of distinctive plants and animals and contains cultural resources significant to the region's Native Americans. About 15 miles upstream of Grand Canyon National Park sits Glen Canyon Dam, completed in 1963, which created Lake Powell. The dam provides hydroelectric power for 200 wholesale customers in six western States, but it has also altered the Colorado River's flow, temperature, and sediment-carrying capacity. Over time this has resulted in beach erosion, invasion and expansion of nonnative species, and losses of native fish. Public concern about the effects of Glen Canyon Dam operations prompted the passage of the Grand Canyon Protection Act of 1992, which directs the Secretary of the Interior to operate the dam 'to protect, mitigate adverse impacts to, and improve values for which Grand Canyon National Park and Glen Canyon National Recreation Area were established...' This legislation also required the creation of a long-term monitoring and research program to provide information that could inform decisions related to dam operations and protection of downstream resources.

Warning Triggers in Environmental Hazards: Who Should Be Warned to Do What and When?

PubMed

Cova, Thomas J; Dennison, Philip E; Li, Dapeng; Drews, Frank A; Siebeneck, Laura K; Lindell, Michael K

2017-04-01

Determining the most effective public warnings to issue during a hazardous environmental event is a complex problem. Three primary questions need to be answered: Who should take protective action? What is the best action? and When should this action be initiated? Warning triggers provide a proactive means for emergency managers to simultaneously answer these questions by recommending that a target group take a specified protective action if a preset environmental trigger condition occurs (e.g., warn a community to evacuate if a wildfire crosses a proximal ridgeline). Triggers are used to warn the public across a wide variety of environmental hazards, and an improved understanding of their nature and role promises to: (1) advance protective action theory by unifying the natural, built, and social themes in hazards research into one framework, (2) reveal important information about emergency managers' risk perception, situational awareness, and threat assessment regarding threat behavior and public response, and (3) advance spatiotemporal models for representing the geography and timing of disaster warning and response (i.e., a coupled natural-built-social system). We provide an overview and research agenda designed to advance our understanding and modeling of warning triggers. © 2016 Society for Risk Analysis.

Protecting the privacy of individual general practice patient electronic records for geospatial epidemiology research.

PubMed

Mazumdar, Soumya; Konings, Paul; Hewett, Michael; Bagheri, Nasser; McRae, Ian; Del Fante, Peter

2014-12-01

General practitioner (GP) practices in Australia are increasingly storing patient information in electronic databases. These practice databases can be accessed by clinical audit software to generate reports that inform clinical or population health decision making and public health surveillance. Many audit software applications also have the capacity to generate de-identified patient unit record data. However, the de-identified nature of the extracted data means that these records often lack geographic information. Without spatial references, it is impossible to build maps reflecting the spatial distribution of patients with particular conditions and needs. Links to socioeconomic, demographic, environmental or other geographically based information are also not possible. In some cases, relatively coarse geographies such as postcode are available, but these are of limited use and researchers cannot undertake precision spatial analyses such as calculating travel times. We describe a method that allows researchers to implement meaningful mapping and spatial epidemiological analyses of practice level patient data while preserving privacy. This solution has been piloted in a diabetes risk research project in the patient population of a practice in Adelaide. The method offers researchers a powerful means of analysing geographic clinic data in a privacy-protected manner. © 2014 Public Health Association of Australia.

Nuclear mass inventory, photon dose rate and thermal decay heat of spent research reactor fuel assemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pond, R.B.; Matos, J.E.

1996-05-01

As part of the Department of Energy`s spent nuclear fuel acceptance criteria, the mass of uranium and transuranic elements in spent research reactor fuel must be specified. These data are, however, not always known or readily determined. It is the purpose of this report to provide estimates of these data for some of the more common research reactor fuel assembly types. The specific types considered here are MTR, TRIGA and DIDO fuel assemblies. The degree of physical protection given to spent fuel assemblies is largely dependent upon the photon dose rate of the spent fuel material. These data also, aremore » not always known or readily determined. Because of a self-protecting dose rate level of radiation (dose rate greater than 100 ren-x/h at I m in air), it is important to know the dose rate of spent fuel assemblies at all time. Estimates of the photon dose rate for spent MTR, TRIGA and DIDO-type fuel assemblies are given in this report.« less

Privacy and Security in Mobile Health (mHealth) Research

PubMed Central

Arora, Shifali; Yttri, Jennifer; Nilsen, Wendy

2014-01-01

Research on the use of mobile technologies for alcohol use problems is a developing field. Rapid technological advances in mobile health (or mHealth) research generate both opportunities and challenges, including how to create scalable systems capable of collecting unprecedented amounts of data and conducting interventions—some in real time—while at the same time protecting the privacy and safety of research participants. Although the research literature in this area is sparse, lessons can be borrowed from other communities, such as cybersecurity or Internet security, which offer many techniques to reduce the potential risk of data breaches or tampering in mHealth. More research into measures to minimize risk to privacy and security effectively in mHealth is needed. Even so, progress in mHealth research should not stop while the field waits for perfect solutions. PMID:26259009

Certificates of confidentiality: a valuable tool for protecting genetic data.

PubMed

Earley, C L; Strong, L C

1995-09-01

Protecting the confidentiality of genetic research data is an important aspect of genetic research that has been discussed in various forums. Research data must be protected to prevent discrimination and its use in litigation. The certificate of confidentiality was created to protect the subjects of alcohol- and drug-abuse studies, who may be engaging in illegal activities. As revised in 1988, the certificate protects investigators engaging in other kinds of studies from being compelled to reveal information about subjects. Because the certificate protects information that could damage a subject's financial or social standing or employability, it is an appropriate tool to use to maintain the confidentiality of genetic data. The Department of Health and Human Services issues the certificates; the procedure for applying for a certificate of confidentiality is presented.

A longitudinal investigation of the relation between nonsuicidal self-injury and spirituality/religiosity.

PubMed

Good, Marie; Hamza, Chloe; Willoughby, Teena

2017-04-01

Despite increased research on factors that predict engagement in nonsuicidal self-injury (NSSI), one factor that has been neglected is spirituality/religiosity. While some researchers suggest that spiritual/religious beliefs and practice may protect against aversive mental health outcomes, it also is possible that certain aspects of spirituality/religiosity - specifically doubt and questioning - may be distressing. In this study, we examined whether multiple dimensions of spirituality/religiosity, including the often-overlooked experience of doubt/questioning, were associated with engagement in NSSI among university students over time. Participants included 1,132 (70.5% female) first-year undergraduate students (Mean age=19.06, SD=1.05) from a Canadian university who were surveyed first in their freshman year, and again one year later. Auto-regressive cross-lagged analyses revealed a bidirectional relation between doubt/questioning and NSSI, where higher doubt/questioning predicted increased NSSI over time (after controlling for baseline depressive symptoms), and vice versa. There were no longitudinal associations between general spirituality/religiosity (i.e., general beliefs/practice) and NSSI. Our findings suggest questioning and doubt may be distressing for some individuals, and predict increased risk for NSSI as a form of coping. Further, higher NSSI may predict increases in questioning/doubt over time. However, the hypothesis that general spirituality/religiosity may protect against NSSI, was not supported. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Academic plastic surgery: faculty recruitment and retention.

PubMed

Chen, Jenny T; Girotto, John A; Kitzmiller, W John; Lawrence, W Thomas; Verheyden, Charles N; Vedder, Nicholas B; Coleman, John J; Bentz, Michael L

2014-03-01

A critical element of a thriving academic plastic surgery program is the quality of faculty. A decline in recruitment and retention of faculty has been attributed to the many challenges of academic medicine. Given the substantial resources required to develop faculty, academic plastic surgery has a vested interest in improving the process of faculty recruitment and retention. The American Council of Academic Plastic Surgeons Issues Committee and the American Society of Plastic Surgeons/Plastic Surgery Foundation Academic Affairs Council surveyed the 83 existing programs in academic plastic surgery in February of 2012. The survey addressed the faculty-related issues in academic plastic surgery programs over the past decade. Recruitment and retention strategies were evaluated. This study was designed to elucidate trends, and define best strategies, on a national level. Academic plastic surgery programs have added substantially more full-time faculty over the past decade. Recruitment efforts are multifaceted and can include guaranteed salary support, moving expenses, nurse practitioner/physician's assistant hires, protected time for research, seed funds to start research programs, and more. Retention efforts can include increased compensation, designation of a leadership appointment, protected academic time, and call dilution. Significant change and growth of academic plastic surgery has occurred in the past decade. Effective faculty recruitment and retention are critical to a successful academic center. Funding sources in addition to physician professional fees (institutional program support, grants, contracts, endowment, and so on) are crucial to sustain the academic missions.

RESEARCH PROGRAMS AT THE ECOSYSTEMS RESEARCH DIVISION, U.S. ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

This presentation presents information on the research programs at the Ecosystems Research Division (ERD) of the U.S. Environmental Protection Agency located in Athens, Georgia. The presentation gives an overview of the Agency, laws and regulations that the Agency operates under,...

Research on protection of steel piles of Baoshan general steel factory wharf by using DZ and DZ-2 tapes

NASA Astrophysics Data System (ADS)

Dai, Zhongdao; Ni, Xiangyu; Xia, Gengmei; Yuan, Li

1989-12-01

Steel piles at the tidal zone can be seriously corroded. Common protective methods such as painting or coating with rubber or other protective materials, etc. cannot provide full protection when used as supplementary protection because these traditional methods require strict pretreatment and sealing of the metallic surface from the corrosive mediums, and time for the protective coatings to solidify. This is very difficult under the severe action of waves and surges on the sea. With our oil-soluble DZ-2 tape, protection efficiency for hanging steel plates at the tidal and splash zones reaches to 82 99%. The protection efficiency of water soluble DZ tape at the tidal zone reaches to 92.9%. The DZ and DZ-2 tapes can rapidly reduce the original corrosion velocity to ten percent and one percent respectively as fully proved by the 500 hour rapid corrosion testing with indoor salt fog and by the relevant electrochemical parameters of instantaneous corrosion velocity, etc. DZ tape absorbs much OH- to cause a pH rise. A synergistic protective effect is gained when DZ tape is used together with cathodic protection of steel piles at the tidal zone. The working principle of DZ tape is different from that of DZ-2 tape even though they are composed of the same chemical materials. The latter provides protection because of the close affinity between metal and its carboxyl group shields the active centre at the metal surface to reduce the activation energy of metal. The carbon chain forms a covering oil film of netted structure.

40 CFR 18.8 - Stipends, Allowances, and Benefits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Environmental Protection Research fellow may be authorized travel and transportation or relocation allowances... provided herein, an Environmental Protection Research fellow shall be entitled to travel and transportation... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Stipends, Allowances, and Benefits. 18...

Certificates of Confidentiality: Legal Counsels’ Experiences with and Perspectives on Legal Demands for Research Data

PubMed Central

Wolf, Leslie E.; Dame, Lauren A.; Patel, Mayank J.; Williams, Brett A.; Austin, Jeffrey A.; Beskow, Laura M.

2013-01-01

The Certificate of Confidentiality (Certificate) is an important tool for protecting identifiable, sensitive human subjects research data in the United States. However, little is known about the Certificate’s effectiveness in protecting identifiable data. We interviewed 24 legal counsel representing U.S. research institutions about their experiences with legal demands for research data. Our respondents reported few, if any, legal demands over the course of their tenure, but two-thirds had experience with legal demands for data protected by a Certificate. They reported such demands often were resolved without disclosure of identifiable research data, typically without court intervention. While our respondents reported similar success protecting identifiable data in court, they often did not rely on the Certificate to do so. PMID:23086043

The Effect of the General Data Protection Regulation on Medical Research

PubMed Central

2017-01-01

Background The enactment of the General Data Protection Regulation (GDPR) will impact on European data science. Particular concerns relating to consent requirements that would severely restrict medical data research have been raised. Objective Our objective is to explain the changes in data protection laws that apply to medical research and to discuss their potential impact. Methods Analysis of ethicolegal requirements imposed by the GDPR. Results The GDPR makes the classification of pseudonymised data as personal data clearer, although it has not been entirely resolved. Biomedical research on personal data where consent has not been obtained must be of substantial public interest. Conclusions The GDPR introduces protections for data subjects that aim for consistency across the EU. The proposed changes will make little impact on biomedical data research. PMID:28235748

Protecting and Respecting the Vulnerable: Existing Regulations or Further Protections?

PubMed Central

Solomon, Stephanie R.

2013-01-01

Scholars and policymakers continue to struggle over the meaning of the word “vulnerable” in the context of research ethics. One major reason for the stymied discussions regarding vulnerable populations is that there is no clear distinction between accounts of research vulnerabilities that exist for certain populations and discussions of research vulnerabilities that require special regulations in the context of research ethics policies. I suggest an analytic process by which to ascertain whether particular vulnerable populations should be contenders for additional regulatory protections. I apply this process to two vulnerable populations: the cognitively vulnerable and the economically vulnerable. I conclude that a subset of the cognitively vulnerable require extra protections while the economically vulnerable should be protected by implementing existing regulations more appropriately and rigorously. Unless or until the informed consent process is more adequately implemented and the distributive justice requirement of the Belmont Report is emphasized and operationalized, the economically disadvantaged will remain particularly vulnerable to the harm of exploitation in research. PMID:23329228

Protecting and respecting the vulnerable: existing regulations or further protections?

PubMed

Solomon, Stephanie R

2013-02-01

Scholars and policymakers continue to struggle over the meaning of the word "vulnerable" in the context of research ethics. One major reason for the stymied discussions regarding vulnerable populations is that there is no clear distinction between accounts of research vulnerabilities that exist for certain populations and discussions of research vulnerabilities that require special regulations in the context of research ethics policies. I suggest an analytic process by which to ascertain whether particular vulnerable populations should be contenders for additional regulatory protections. I apply this process to two vulnerable populations: the cognitively vulnerable and the economically vulnerable. I conclude that a subset of the cognitively vulnerable require extra protections while the economically vulnerable should be protected by implementing existing regulations more appropriately and rigorously. Unless or until the informed consent process is more adequately implemented and the distributive justice requirement of the Belmont Report is emphasized and operationalized, the economically disadvantaged will remain particularly vulnerable to the harm of exploitation in research.

An analysis of child protection 'standard operating procedures for research' in higher education institutions in the United Kingdom.

PubMed

Randall, Duncan; Childers-Buschle, Kristin; Anderson, Anna; Taylor, Julie

2015-09-29

Interest in children's agency within the research process has led to a renewed consideration of the relationships between researchers and children. Child protection concerns are sometimes not recognised by researchers, and sometimes ignored. Yet much research on children's lives, especially in health, has the potential to uncover child abuse. University research guidance should be in place to safeguard both researchers and the populations under scrutiny. The aim of this study was to examine university guidance on protecting children in research contexts. Child protection Standard Operating Procedures (SOPs) were requested from institutions with Research Assessment Exercise (2008) profiles in the top two quartiles according to published league tables. Procedures were included if they applied across the institution and if they were more extensive than stating the university's general application of the UK Disclosure and Barring Service process. A typology for scoring the SOPs was designed for this study based on the authors' previous work. The typology and the raw data scoring were reviewed independently by each of the team members and collectively agreed. The raw scores were charted and analysed using descriptive statistics. SOPs for research conduct amongst vulnerable groups were sought from 83 institutions. Forty HEIs provided policies which met the inclusion criteria. The majority did not mention children, young people or vulnerable adults as a whole, although children in nurseries and young people in universities were addressed. Only three institutions scored over 50 out of a possible 100. The mean score was 17.4. More than half the HEIs made no reference to vetting/barring schemes in research, only eight universities set out a training programme on child protection. Research was often not mentioned in the SOPs and only six mention children in research, with only two fully recognising the extent of child protection in research. There is potential for researchers to recognise and respond to maltreatment of children who participate in research. However, the majority of HEIs do not have an overt culture of safeguarding. There is confusion over what are the roles and responsibilities of HEIs in relation to research that involves children. The policies that are meant to support and guide research practice, so that children are protected, are in the most part non-existent or poorly developed.

Developing A Radiation Protection Hub.

PubMed

Hertel, Nolan E

2017-02-01

The Where are the Radiation Professionals (WARP)? statement issued by the National Council on Radiation Protection and Measurements estimates that in 10 y, there will be a human capital crisis across the radiation safety community. The ability to respond to this shortage will be amplified by the fact that many radiation protection (health physics) academic programs will find it difficult to justify their continued existence since they are low-volume programs, both in terms of enrollment and research funding, compared to the research funding return and visibility of more highly subscribed and highly funded academic disciplines. In addition, across the national laboratory complex, radiation protection research groups have been disbanded or dramatically reduced in size. The loss of both of these national resources is being accelerated by low and uncertain government funding priorities. The most effective solution to this problem would be to form a consortium that would bring together the radiation protection research, academic, and training communities. The goal of such a consortium would be to engage in research, education, and training of the next generation of radiation protection professionals. Furthermore, the consortium could bring together the strengths of different universities, national laboratory programs, and other entities in a strategic manner to accomplish a multifaceted research, educational, and training agenda. This vision would forge a working and funded relationship between major research universities, national laboratories, 4-y degree institutions, technical colleges, and other partners.

76 FR 10584 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... ">[email protected] epa.gov . 2. PP 0E7802. (EPA-HQ-OPP-2010-1018). Interregional Research Project Number 4 (IR....gov ">[email protected] epa.gov . 3. PP 0E7804. (EPA-HQ-OPP-2010-0472). Interregional Research Project No....gov ">[email protected] epa.gov . 4. PP 0E7809. (EPA-HQ-OPP-2010-1017). Interregional Research Project No...

Gender Differences in NATO Anthropometry and the Implication for Protective Equipment

DTIC Science & Technology

2008-09-01

National Research Council 2800 Q Street Wright-Patterson AFB OH 45433-7947 Kathleen M. Robinette Biomechanics Branch Biosciences and Protection...Air Force Research Laboratory Human Effectiveness Directorate Biosciences and Protection Division Biomechanics ...BARRY REEDER, Work Unit Manager MARK M. HOFFMAN, Deputy Chief Biomechanics

Nursing research in the United States: the protection of human subjects.

PubMed

Oddi, L F; Cassidy, V R

1990-01-01

In the United States the protection of the rights of human subjects in experimentation has evolved at three levels: professional, public, and private. At the professional level, codes, guidelines and the Patient's Bill of Rights address the issues of protecting the dignity, privacy and autonomy of individuals who serve as research subjects. At the public level, regulations promulgated by the Food and Drug Administration and the Department of Health and Human Services have become the standard for protecting human subjects. At the private level, United States common law regulates the conduct of individual researchers by requiring them to act in a manner consistent with generally accepted standards of care. As professionals, nurses must be actively involved in the formation of public policy regarding the conduct of research and strive to formulate a research agenda that will ensure that the ethics of research in nursing is above question.

The Effect of the General Data Protection Regulation on Medical Research.

PubMed

Rumbold, John Mark Michael; Pierscionek, Barbara

2017-02-24

The enactment of the General Data Protection Regulation (GDPR) will impact on European data science. Particular concerns relating to consent requirements that would severely restrict medical data research have been raised. Our objective is to explain the changes in data protection laws that apply to medical research and to discuss their potential impact. Analysis of ethicolegal requirements imposed by the GDPR. The GDPR makes the classification of pseudonymised data as personal data clearer, although it has not been entirely resolved. Biomedical research on personal data where consent has not been obtained must be of substantial public interest. The GDPR introduces protections for data subjects that aim for consistency across the EU. The proposed changes will make little impact on biomedical data research. ©John Mark Michael Rumbold, Barbara Pierscionek. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 24.02.2017.

Synthesis of potential radioprotective components from Chinese herb drug Rhizoma Chuanxiong (rhizome of Ligusticum chuanxiong Hort. , umbelliferae)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, X.

1993-01-01

The ethanolic extracts of some Chinese traditional herb drugs, reported by Hong-Fu Wang et al. in China, could inhibit platelet aggregation as well as protect against radiation damage in mice, rat and rabbits. The inhibitory effects of the extracts of five Chinese drugs on the rate of platelet aggregation were observed in both in vitro and in vivo tests, averaging 23--53% in vitro and 46--69% in vivo. Antiradiation tests on mice vs. 7.5--8.0 Gy of [gamma]-radiation, using the herb drug extracts as protective agents, showed increasing survival rates by 8--50%. Based on Hong-Fu Wang's report, a search for the activemore » constituents of these herb drugs in inhibiting platelet aggregation and protecting animals against radiation damage was started. In this research program, a Chinese traditional drug, Rhizoma Chuanxiong (rhizome of Ligusticum chuanxiong Hort.) was chosen. Three types of chemicals present in Rhizoma Chuanxiong, appeared promising for testing: 1-(5-hydroxymethyl-2-furyl)-9H-pyrido-(3,4-b)indole, 4-hydroxyl-3-butylidenephthalide and 5-hydroxyl-3-butylidenephthalide, and 4-hydroxyl-3-methoxycinnamyl 4-hydroxyl-3-methoxycinnamate. A total of 56 compounds of these derivatives has been synthesized and 30 were synthesized for the first time. The structure elucidation of these compounds was based on IR, [sup 1]H NMR and elemental analysis. From this research program, a very mild dehydrogenation method was developed. It was by using 2,3-dichloro-5,6-dicyanobenzoquinone in acetonitrile at ice bath temperature to dehydrogenate 1-(5-hydroxymethyl-2-furyl)-1,2,3,4-tetrahydro-9H-pyrido-(3,4-b)indole into 1-(5-hydroxymethyl-2-furyl)-9H-pyrido-(3,4-b)indole. This project showed for the first time that harmanoid alkaloids have the activity of inhibition of plate aggregation by 4 to 23 times that of aspirin. These results aid in establishing a relation between radiation protection in animals and prevention of platelet hyperaggregation.« less

Engaging Institutional Review Boards in Developing a Brief, Community-Responsive Human Subjects Training for Community Partners.

PubMed

Calzo, Jerel P; Bogart, Laura M; Francis, Evelyn; Kornetsky, Susan Z; Winkler, Sabune J; Kaberry, Julie

2016-01-01

Engaging community partners as co-investigators in community-based participatory research (CBPR) requires certification in the rules, ethics, and principles governing research. Despite developments in making human research protection trainings more convenient and standardized (eg, self-paced Internet modules), time constraints and the structure of the content (which may favor academic audiences) may hinder the training of community partners. This paper is motivated by a case example in which academic and community partners, and stakeholders of a community-based organization actively engaged the leadership of a pediatric hospital-based institutional review board (IRB) in implementing a brief, community-responsive human subjects training session. A 2-hour, discussion-based human subjects training was developed via collaborations between the IRB and the community and academic partners. Interviews with trainees and facilitators after the training were used to evaluate its acceptability and possible future applications. Local IRBs have the potential to assist community partners in building sufficient knowledge of human subjects research protections to engage in specific projects, thereby expediting the progress of vital research to address community needs. We propose the need for developing truncated human subjects education materials to train and certify community partners, and creating formally organized entities within academic and medical institutions that specialize in community-based research to guide the development and implementation of alternative human subjects training certification opportunities for community partners.

LANDSAT digital data processing: A near real-time application. [Gulf of Mexico

NASA Technical Reports Server (NTRS)

Barker, J. L.; Bohn, C.; Stuart, L.; Hill, J.

1975-01-01

An application of rapid generation of classed digital images from LANDSAT-1 was demonstrated and its feasibility evaluated by NASA in conjunction with the Environmental Protection Agency (EPA), Texas A and M University (TAMU), and the Cousteau Society. The primary purpose was to show that satellite data could be processed and transmitted to the Calypso, which was used as a research vessel, in time for use in directing it to specific locations of possible plankton upwellings, sediment, or other anomalies in the coastal water areas along the Gulf of Mexico.

Physician to investigator: clinical practice to clinical research--ethical, operational, and financial considerations.

PubMed

Pierre, Christine

2008-01-01

Physicians who participate in clinical research studies gain benefits for themselves, their practice, and their patients. Historically, private practice physicians have chosen to defer to their counterparts in academic medicine when it comes to contributing to scientific advancement through clinical studies. A growing number of private practice physicians are now taking a serious second look and deciding that there are unique benefits for both the practice and the patient. Physicians who decide to participate in clinical research should give serious consideration to the time and resources that are required to meet both federal regulations and industry standards. In addition, ethical and scientific principles for assuring the protection of human research subjects must be a paramount commitment.

An Alternative Time Metric to Modified Tau for Unmanned Aircraft System Detect And Avoid

NASA Technical Reports Server (NTRS)

Wu, Minghong G.; Bageshwar, Vibhor L.; Euteneuer, Eric A.

2017-01-01

A new horizontal time metric, Time to Protected Zone, is proposed for use in the Detect and Avoid (DAA) Systems equipped by unmanned aircraft systems (UAS). This time metric has three advantages over the currently adopted time metric, modified tau: it corresponds to a physical event, it is linear with time, and it can be directly used to prioritize intruding aircraft. The protected zone defines an area around the UAS that can be a function of each intruding aircraft's surveillance measurement errors. Even with its advantages, the Time to Protected Zone depends explicitly on encounter geometry and may be more sensitive to surveillance sensor errors than modified tau. To quantify its sensitivity, simulation of 972 encounters using realistic sensor models and a proprietary fusion tracker is performed. Two sensitivity metrics, the probability of time reversal and the average absolute time error, are computed for both the Time to Protected Zone and modified tau. Results show that the sensitivity of the Time to Protected Zone is comparable to that of modified tau if the dimensions of the protected zone are adequately defined.

Blast and Fragment Protective Sandwich Panel Concepts for Stainless Steel Monohull Designs

DTIC Science & Technology

2008-10-21

to draw broader conclusions. 8. Concluding remarks The resistance of metallic sandwich panels to localized spherical impulsive sources has been...hour per response, including the time for reviewing instructions, searching existing data sources , gathering and maintaining the data needed, and...applications and ship hull blister attachments. Technical Approach The approach used in this research program exploited progress made in metallic

Pedestrian Levels of Service (LOS) at Muir Woods National Monument (California): An introduction to multi-modal LOS for parks and protected areas

Treesearch

Peter R. Pettengill; Robert E. Manning; William Valliere; Laura E. Anderson

2010-01-01

Historically, transportation planning and management have been guided largely by principles of efficiency. Specifically, the Transportation Research Board has utilized a levels of service (LOS) framework to assess quality of service in terms of traffic congestion, speed and travel time, and maximum road capacity. In the field of park and outdoor recreation management,...

Development of a viability standard curve for microencapsulated probiotic bacteria using confocal microscopy and image analysis software.

PubMed

Moore, Sarah; Kailasapathy, Kasipathy; Phillips, Michael; Jones, Mark R

2015-07-01

Microencapsulation is proposed to protect probiotic strains from food processing procedures and to maintain probiotic viability. Little research has described the in situ viability of microencapsulated probiotics. This study successfully developed a real-time viability standard curve for microencapsulated bacteria using confocal microscopy, fluorescent dyes and image analysis software. Copyright © 2015 Elsevier B.V. All rights reserved.

Experimental research results of solid particle erosion resistance of blade steel with protective coating

NASA Astrophysics Data System (ADS)

Kachalin, G. V.; Mednikov, A. F.; Tkhabisimov, A. B.; Seleznev, L. I.

2017-11-01

The paper presents the results of metallographic studies and solid particle erosion tests of uncoated blade steel 20kH13 samples and samples with a protective coating based on chromium carbide (Cr-CrC) at a flow (air) velocity CA = 180 m/s, flow temperature tA = 25 °C, attack angle α = 30° and consumption of solid abrasive particles GP = 5·10-4 kg/s. It was found that the coating has a granular structure, a thickness is about 11 μm, the microhardness of the surface is 1520 ± 50 HV0.05. Processing of the obtained data by statistical analysis methods showed that the protective coating based on Cr-CrC increases the solid particle erosion resistance of the blade steel 20kH13 by the incubation-transitional period duration more than 2.5 times.

[Management of Personal Information in Clinical Laboratory Medicine:--Chairmen's Introductory Remarks].

PubMed

Yoshida, Hiroshi; Shimetani, Naoto

2014-11-01

The Japanese Society of Laboratory Medicine has been running its own Medical Safety Committee, and holding a symposium on medical safety during the annual meeting. The medical world is filled with a considerable amount of personal information, including genetic information, the ultimate personal information. We, as medical staff, have to manage such personal information not only in times of peace but also during disasters or emergency situations. In Japan, the Act on the Protection of Personal Information is currently being implemented, but a number of problems remain. Human beings have entered the information technology era, including electrical medical record systems, which is useful for research and education besides medical practice. This is why personal information must be more effectively protected from leakage, misconception, and abuse. We should create a sound system to manage personal information, with the spirit of protecting patient information that originated from the Oath of Hippocrates.

Live Attenuated Yellow Fever 17D Vaccine: A Legacy Vaccine Still Controlling Outbreaks In Modern Day.

PubMed

Collins, Natalie D; Barrett, Alan D T

2017-03-01

Live attenuated 17D vaccine is considered one of the safest and efficacious vaccines developed to date. This review highlights what is known and the gaps in knowledge of vaccine-induced protective immunity. Recently, the World Health Organization modifying its guidance from 10-year booster doses to one dose gives lifelong protection in most populations. Nonetheless, there are some data suggesting immunity, though protective, may wane over time in certain populations and more research is needed to address this question. Despite having an effective vaccine to control yellow fever, vaccine shortages were identified during outbreaks in 2016, eventuating the use of a fractional-dosing campaign in the Democratic Republic of the Congo. Limited studies hinder identification of the underlying mechanism(s) of vaccine longevity; however, concurrent outbreaks during 2016 provide an opportunity to evaluate vaccine immunity following fractional dosing and insights into vaccine longevity in populations where there is limited information.

Plastic litter in sediments from a marine area likely to become protected (Aeolian Archipelago's islands, Tyrrhenian sea).

PubMed

Fastelli, Paolo; Blašković, Andrea; Bernardi, Giulia; Romeo, Teresa; Čižmek, Hrvoje; Andaloro, Franco; Russo, Giovanni F; Guerranti, Cristiana; Renzi, Monia

2016-12-15

This research aims to define for the first time levels and patterns of different litter groups (macro, meso and microplastics) in sediments from a marine area designed for the institution of a new marine protected area (Aeolian Archipelago, Italy). Microplastics resulted the principal group and found in all samples analyzed, with shape and colours variable between different sampling sites. MPs levels measured in this study are similar to values recorded in harbour sites and lower than reported in Adriatic Sea, while macroplastics levels are notably lower than in harbor sites. Sediment grain-size and island extent resulted not significant in determining levels and distribution of plastic debris among islands. In the future, following the establishment of the MPA in the study area, these basic data will be useful to check for potential protective effects on the levels and distribution of plastic debris. Copyright © 2016 Elsevier Ltd. All rights reserved.

Implementation of IAU Resolution 2009 B5, "in Defence of the night sky and the right to starlight"

NASA Astrophysics Data System (ADS)

Green, Richard F.; Walker, Constance Elaine

2015-08-01

IAU Resolution 2009 B5 calls on IAU members to protect the public`s right to an unpolluted night sky as well as the astronomical quality of the sky around major research observatories. The approach of Commission 50 - astronomical site protection - includes working with the lighting industry for appropriate products from rapidly evolving solid state technology, arming astronomers with training and materials for presentation, selective endorsement of key protection issues, cooperation with other IAU commissions for education and outreach with particular current attention to the International Year of Light, and provision of clear quantitative priorities for outdoor lighting standards. In 2012, these priorities were defined as full cut-off shielding, spectral management to minimize output shortward of 500 nm, and zone- and time-appropriate lighting levels. Revisiting the specifics of these priorities will be a topic for current discussion.

Optimizing romanian maritime coastline using mathematical model Litpack

NASA Astrophysics Data System (ADS)

Anton, I. A.; Panaitescu, M.; Panaitescu, F. V.

2017-08-01

There are many methods and tools to study shoreline change in coastal engineering. LITPACK is a numerical model included in MIKE software developed by DHI (Danish Hydraulic Institute). With this matehematical model we can simulate coastline evolution and profile along beach. Research and methodology: the paper contents location of the study area, the current status of Midia-Mangalia shoreline, protection objectives, the changes of shoreline after having protected constructions. In this paper are presented numerical and graphycal results obtained with this model for studying the romanian maritime coastline in area MIDIA-MANGALIA: non-cohesive sediment transport, long-shore current and littoral drift, coastline evolution, crossshore profile evolution, the development of the coastline position in time.

High Energy Failure Containment for Spacecraft

NASA Technical Reports Server (NTRS)

Pektas, Pete; Baker, Christopher

2011-01-01

Objective: The objective of this paper will be to investigate advancements and any commonality between spacecraft debris containment and the improvements being made in ballistic protection. Scope: This paper will focus on cross application of protection devices and methods, and how they relate to protecting humans from failures in spacecraft. The potential gain is to reduce the risk associated with hardware failure, while decreasing the weight and size of energy containment methods currently being used by the government and commercial industry. Method of Approach: This paper will examine testing that has already been accomplished in regards to the failure of high energy rotating hardware and compare it to advancements in ballistic protection. Examples are: DOT research and testing of turbine containment as documented in DOT/FAA/AR-96/110, DOT/FAA/AR-97/82, DOT/FAA/AR-98/22. It will also look at work accomplished by companies such as ApNano and IBD Deisenroth in the development of nano ceramics and nanometric steels. Other forms of energy absorbent materials and composites will also be considered and discussed. New Advances in State of the Art: There have been numerous advances in technology in regards to high energy debris containment and in the similar field of ballistic protection. This paper will discuss methods such as using impregnated or dry Kevlar, ceramic, and nano-technology which have been successfully tested but are yet to be utilized in spacecraft. Reports on tungsten disulfide nanotubes claim that they are 4-5 times stronger than steel and reports vary about the magnitude increase over Kevlar, but it appears to be somewhere in the range of 2-6 times stronger. This technology could also have applications in the protection of pressure vessels, motor housings, and hydraulic component failures.

Expertise, Time, Money, Mentoring, and Reward: Systemic Barriers That Limit Education Researcher Productivity-Proceedings From the AAMC GEA Workshop.

PubMed

Yarris, Lalena M; Juve, Amy Miller; Artino, Anthony R; Sullivan, Gail M; Rougas, Steven; Joyce, Barbara; Eva, Kevin

2014-09-01

To further evolve in an evidence-based fashion, medical education needs to develop and evaluate new practices for teaching, learning, and assessment. However, educators face barriers in designing, conducting, and publishing education research. To explore the barriers medical educators face in formulating, conducting, and publishing high-quality medical education research, and to identify strategies for overcoming them. A consensus workshop was held November 5, 2013, at the Association of American Medical Colleges annual meeting. A working group of education research experts and educators completed a preconference literature review focusing on barriers to education research. During the workshop, consensus-based and small group techniques were used to refine the broad themes into content categories. Attendees then ranked the most important barriers and strategies for overcoming them with the highest potential impact. Barriers participants faced in conducting quality education research included lack of (1) expertise, (2) time, (3) funding, (4) mentorship, and (5) reward. The strategy considered most effective in overcoming these barriers involved building communities of education researchers for collaboration and networking, and advocating for education researchers' interests. Other suggestions included trying to secure increased funding opportunities, developing mentoring programs, and encouraging mechanisms to ensure protected time. Barriers to education research productivity clearly exist. Many appear to result from feelings of isolation that may be overcome with systemic efforts to develop and enable communities of practice across institutions. Finally, the theme of "reward" is novel and complex and may have implications for education research productivity.

[Problems associated with the prevention of cruelty to animals in modern livestock breeding (author's transl)].

PubMed

Schultze-Petzold, H

1976-01-01

Regulations for the protection of useful animals can be traced to the early history of Law. The reason for such regulations has hardly changed up to the present: the expedient incorporation of the animal into the hierachy of values of the prevailing times. Decisive impulses invariably originated from the legal conception, the need for legal protection as well as from the scientific conceptions of society. The development rarely took a linear course and was not without setbacks. The prevention of cruelty to animals has always been faced with particular conflicting situations. Our pluralistic society with its marked philosophy of profit-making has to face such a problem, in particular as a result of livestock keeping in modern systems. The necessity and legitimacy of a permanent supply of large quantities of high-grade animal foodstuffs to be offered to our present industrial society on a competitive and low-cost basis, have contributed to this development. The public and parliament have for some time been demanding a modern federal act for the prevention of cruelty to animals based on a technical conception allowing also those questions of animal protection related to the present keeping of useful animals to be integrated, thus achieving a gradual balancing of interests. Such an Animal Protection Act came into force on October 1, 1972. On account of its scientific orientation it prompts us to give renewed thought to many present-day ideas about the keeping of animals, especially of useful animals, employing modern systems. With this objective in mind the Act has already strongly influenced the developing international harmonization of provisions for Animal Protection. The problems linked with "Animal Protection/Keeping of Useful Animals" require a harmonization of the ethical, scientific, economic and legal aspects as an indispensable prerequisite. On the basis of expert opinions prepared by a group of specialists of the Federal Ministry of Agriculture on the minimum requirements to be satisfied by modern systems of fowl breeding, the various scientific basic concepts and evaluations are presented. The value of the information yielded by modern research into animal behaviour is emphasized in this connection. Future legal ordinances in accordance with Clause 13, para 1 of the Animal Protection Act of July 24, 1972 for the protection of useful animals kept in modern systems call for a particularly thorough scientific foundation which must also stand up to examination by the courts. The problems to be solved require comprehensive research. An urgent task for the near future will be to give the resolution of these problems a firm scientific base. In addition to the topical approach to the subject "Animal Protection/Keeping of Useful Animals", indications are given for a comprehensive approach which will prove indispensable in the future...

45 CFR 46.204 - Research involving pregnant women or fetuses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research involving pregnant women or fetuses. 46... PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.204 Research involving pregnant women or fetuses. Pregnant women or fetuses may be...

45 CFR 46.204 - Research involving pregnant women or fetuses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Research involving pregnant women or fetuses. 46... PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.204 Research involving pregnant women or fetuses. Pregnant women or fetuses may be...

45 CFR 46.204 - Research involving pregnant women or fetuses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Research involving pregnant women or fetuses. 46... PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.204 Research involving pregnant women or fetuses. Pregnant women or fetuses may be...

45 CFR 46.204 - Research involving pregnant women or fetuses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Research involving pregnant women or fetuses. 46... PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.204 Research involving pregnant women or fetuses. Pregnant women or fetuses may be...

45 CFR 46.204 - Research involving pregnant women or fetuses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Research involving pregnant women or fetuses. 46... PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.204 Research involving pregnant women or fetuses. Pregnant women or fetuses may be...

42 CFR 2.21 - Relationship to Federal statutes protecting research subjects against compulsory disclosure of...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Relationship to Federal statutes protecting research subjects against compulsory disclosure of their identity. 2.21 Section 2.21 Public Health PUBLIC... research subjects against compulsory disclosure of their identity. (a) Research privilege description...

42 CFR 2.21 - Relationship to Federal statutes protecting research subjects against compulsory disclosure of...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Relationship to Federal statutes protecting research subjects against compulsory disclosure of their identity. 2.21 Section 2.21 Public Health PUBLIC... research subjects against compulsory disclosure of their identity. (a) Research privilege description...

42 CFR 2.21 - Relationship to Federal statutes protecting research subjects against compulsory disclosure of...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Relationship to Federal statutes protecting research subjects against compulsory disclosure of their identity. 2.21 Section 2.21 Public Health PUBLIC... research subjects against compulsory disclosure of their identity. (a) Research privilege description...

42 CFR 2.21 - Relationship to Federal statutes protecting research subjects against compulsory disclosure of...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Relationship to Federal statutes protecting research subjects against compulsory disclosure of their identity. 2.21 Section 2.21 Public Health PUBLIC... research subjects against compulsory disclosure of their identity. (a) Research privilege description...

Views of academic and community partners regarding participant protections and research integrity: a pilot focus group study.

PubMed

Anderson, Emily E

2013-02-01

When community partners have direct interaction with human research participants, it is important to consider potential threats to participant protections and research integrity. Few studies have directly compared the views of academic and community partners. This pilot focus group study explores the views of academic partners (APs) and community partners (CPs) regarding challenges to the protection of research participants and research integrity in community-engaged research (CEnR). Data are analyzed to understand how APs and CPs define and think about ethical problems and how meaning and analysis may differ between the two groups. Findings have implications for the development of research ethics training materials for academic-community research partnerships and IRBs; best practices for CEnR; and future research on ethical issues in CEnR.

34 CFR 97.116 - General requirements for informed consent.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 97.116 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research..., no investigator may involve a human being as a subject in research covered by this policy unless the...

48 CFR 3424.170 - Protection of human subjects.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Protection of human... Individual Privacy 3424.170 Protection of human subjects. In this subsection, “Research” means a systematic... generalizable knowledge. (34 CFR 97.102(d)) Research is considered to involve human subjects when a researcher...

48 CFR 3424.170 - Protection of human subjects.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Protection of human... Individual Privacy 3424.170 Protection of human subjects. In this subsection, “Research” means a systematic... generalizable knowledge. (34 CFR 97.102(d)) Research is considered to involve human subjects when a researcher...

48 CFR 3424.170 - Protection of human subjects.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Protection of human... Individual Privacy 3424.170 Protection of human subjects. In this subsection, “Research” means a systematic... generalizable knowledge. (34 CFR 97.102(d)) Research is considered to involve human subjects when a researcher...

48 CFR 3424.170 - Protection of human subjects.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Protection of human... Individual Privacy 3424.170 Protection of human subjects. In this subsection, “Research” means a systematic... generalizable knowledge. (34 CFR 97.102(d)) Research is considered to involve human subjects when a researcher...

40 CFR 11.6 - Access by historical researchers and former Government officials.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Access by historical researchers and former Government officials. 11.6 Section 11.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS PURSUANT TO EXECUTIVE ORDER 11652 § 11.6 Access by historical...

34 CFR 97.116 - General requirements for informed consent.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 97.116 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research..., no investigator may involve a human being as a subject in research covered by this policy unless the...

Time-Of-Travel Tool Protects Drinking Water

EPA Pesticide Factsheets

The Lower Susquehanna Source Water Protection (SWP) Partnership utilizes the Incident Command Tool for Drinking Water Protection (ICWater) to support the Pennsylvania Department of Environmental Protection (PADEP) with real-time spill tracking information.

NEW DIRECTIONS FOR RESEARCH IN EPA

EPA Science Inventory

The Environmental Protection Agency's (EPA) Office of Research and Development (ORD) carries out research programs, many of which help EPA fulfill its environmental protection programs and lead to the development and commercial use of environmental technologies. any of the latter...

The effect of immersion time to low carbon steel hardness and microstructure with hot dip galvanizing coating method

NASA Astrophysics Data System (ADS)

Hakim, A. A.; Rajagukguk, T. O.; Sumardi, S.

2018-01-01

Along with developing necessities of metal materials, these rise demands of quality improvements and material protections especially the mechanical properties of the material. This research used hot dip galvanizing coating method. The objectives of this research were to find out Rockwell hardness (HRb), layer thickness, micro structure and observation with Scanning Electron Microscope (SEM) from result of coating by using Hot Dip Galvanizing coating method with immersion time of 3, 6, 9, and 12 minutes at 460°C. The result shows that Highest Rockwell hardness test (HRb) was at 3 minutes immersion time with 76.012 HRb. Highest thickness result was 217.3 μm at 12 minutes immersion. Microstructure test result showed that coating was formed at eta, zeta, delta and gamma phases, while Scanning Electron Microscope (SEM) showed Fe, Zn, Mn, Si and S elements at the specimens after coating.

On-Line Thermal Barrier Coating Monitoring for Real-Time Failure Protection and Life Maximization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis H. LeMieux

2005-04-01

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Westinghouse Power Corporation proposes a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization'', to develop, build and install the first generation of an on-line TBC monitoring system for use on land-based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability availability maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCs havemore » been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can therefore accelerate the degradation of substrate components materials and eventually lead to a premature failure of critical component and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Westinghouse Power Corporation has teamed with Indigo Systems, a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization in the field of infrared non-destructive examination (NDE), to complete the program.« less

ON-LINE THERMAL BARRIER COATING MONITORING FOR REAL-TIME FAILURE PROTECTION AND LIFE MAXIMIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis H. LeMieux

2003-10-01

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Westinghouse Power Corporation proposes a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization,'' to develop, build and install the first generation of an on-line TBC monitoring system for use on land-based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability, availability, and maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCsmore » have been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can, therefore, accelerate the degradation of substrate component materials and eventually lead to a premature failure of critical components and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Westinghouse Power Corporation has teamed with Indigo Systems, a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization in the field of infrared non-destructive examination (NDE), to complete the program.« less

ON-LINE THERMAL BARRIER COATING MONITORING FOR REAL-TIME FAILURE PROTECTION AND LIFE MAXIMIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis H. LeMieux

2003-07-01

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Westinghouse Power Corporation proposes a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization,'' to develop, build and install the first generation of an on-line TBC monitoring system for use on land-based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability, availability, and maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCsmore » have been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can, therefore, accelerate the degradation of substrate component materials and eventually lead to a premature failure of critical components and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Westinghouse Power Corporation has teamed with Indigo Systems, a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization in the field of infrared non-destructive examination (NDE), to complete the program.« less

On-Line Thermal Barrier Coating Monitoring for Real-Time Failure Protection and Life Maximization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis H. LeMieux

2005-10-01

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Power Generation, Inc proposed a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization'', to develop, build and install the first generation of an on-line TBC monitoring system for use on land-based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability availability maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCs havemore » been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can therefore accelerate the degradation of substrate components materials and eventually lead to a premature failure of critical component and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Power Generation, Inc. has teamed with Indigo Systems, a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization in the field of infrared non-destructive examination (NDE), to complete the program.« less

45 CFR 690.103 - Assuring compliance with this policy-research conducted or supported by any Federal department or...

Code of Federal Regulations, 2010 CFR

2010-10-01

... current assurance, appropriate for the research in question, on file with the Office for Human Research... made to the Office for Human Research Protections, HHS, or any successor office. (b) Departments and... discharge of its responsibilities for protecting the rights and welfare of human subjects of research...

14 CFR 1230.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... current assurance, appropriate for the research in question, on file with the Office for Human Research... made to the Office for Human Research Protections, HHS, or any successor office. (b) Departments and... discharge of its responsibilities for protecting the rights and welfare of human subjects of research...

38 CFR 16.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... current assurance, appropriate for the research in question, on file with the Office for Human Research... Office for Human Research Protections, HHS, or any successor office. (b) Departments and agencies will... discharge of its responsibilities for protecting the rights and welfare of human subjects of research...

Federal Policy for the Protection of Human Subjects. Final Rule. Technical Amendments. Federal Register, Department of Education, 34 CFR Part 97

ERIC Educational Resources Information Center

National Archives and Records Administration, 2005

2005-01-01

The agencies listed in this document are amending the Federal Policy for the Protection of Human Subjects, which was published in the Federal Register on June 18, 1991, to change all references to the Office for Protection from Research Risks (OPRR) to the Office for Human Research Protections (OHRP); revise the footnote found at the end of…

Field efficacy of entomopathogenic fungi Beauveria bassiana (Balsamo.) for the management of mungbean insect pests

NASA Astrophysics Data System (ADS)

Bayu, M. S. Y. I.; Prayogo, Y.

2018-01-01

In order to reduce the use of insecticide, the application of Beauveria bassiana may be an alternative control. The objective of this study was to evaluate the efficacy of B. bassiana for controlling mungbean pest. The experiment was conducted in Ngale Research Station from February to May 2017, using randomized block design, seven treatments, four replicates. The treatments were frequency of application; P1= six times, P2= five times, P3= four times, P4= three times, P5= once, P6= full protection using chemical insecticide, and P7= no protection. Application of B. bassiana four to six times can suppress the population of Empoasca sp., Riptortus linearis, and Maruca testulalis, but did not significantly different with the application of chemical insecticide. Based on the seed weight, application of B. bassiana six times (659.7 g/plot) led to significantly high as compare with the application of chemical insecticide (374 g/plot). Application of B. bassiana tended to be secure to natural enemies, especially Coccinella sp., Oxyopes javanus, and Paederus fuscipes. Both of those predators were not found on the application of chemical insecticide. Hence, B. bassiana can be recommended as a biological agent in integrated pest management component on mungbean because of effective and environmentally friendly.

Human dignity: a philosophical and theological approach.

PubMed

Tomasević, Luka

2010-09-01

We all use the term "human dignity" both often and gladly. This term exists also in legislation, such as declarations and constitutions of some countries, beginning from UNESCO, WHO, Council of Europe, and they all have the same inspiration to achieve the same goal: protection of human dignity. Human dignity seems as a principle connected with the protection of life itself, protection of health, and is also connected with research. But, today it is far more difficult to determine the meaning of this term and on what grounds it is based. Is human dignity something objective or is it grounded on cultural values that vary throughout history? Is the primary finding of human dignity in its self-determination against the power of the community, i.e. state? What do philosophy, and Christian theology have to say on dignity and what are the bioethical implications of our time? The author first introduces us to the development of the meaning of the term "human dignity", starting from the pre-Christian time, through the Christian perception of person and one's dignity, philosophical notion and grounds of human dignity, to then give the idea of dignity according to bioethical standards.

Zebrafish hair cell mechanics and physiology through the lens of noise-induced hair cell death

NASA Astrophysics Data System (ADS)

Coffin, Allison B.; Xu, Jie; Uribe, Phillip M.

2018-05-01

Hair cells are exquisitely sensitive to auditory stimuli, but also to damage from a variety of sources including noise trauma and ototoxic drugs. Mammals cannot regenerate cochlear hair cells, while non-mammalian vertebrates exhibit robust regenerative capacity. Our research group uses the lateral line system of larval zebrafish to explore the mechanisms underlying hair cell damage, identify protective therapies, and determine molecular drivers of innate regeneration. The lateral line system contains externally located sensory organs called neuromasts, each composed of ˜8-20 hair cells. Lateral line hair cells are homologous to vertebrate inner ear hair cells and share similar susceptibility to ototoxic damage. In the last decade, the lateral line has emerged as a powerful model system for understanding hair cell death mechanisms and for identifying novel protective compounds. Here we demonstrate that the lateral line is a tractable model for noise-induced hair cell death. We have developed a novel noise damage system capable of inducing over 50% loss of lateral line hair cells, with hair cell death occurring in a dose- and time-dependent manner. Cell death is greatest 72 hours post-exposure. However, early signs of hair cell damage, including changes in membrane integrity and reduced mechanotransduction, are apparent within hours of noise exposure. These features, early signs of damage followed by delayed hair cell death, are consistent with mammalian data, suggesting that noise acts similarly on zebrafish and mammalian hair cells. In our future work we will use our new model system to investigate noise damage events in real time, and to develop protective therapies for future translational research.

An Ex Vivo Comparison of 2 Cyanoacrylate Skin Protectants.

PubMed

Gibson, Daniel J

The purpose of these experiments was to compare 2 commercially available skin protectants with different chemical compositions. Two materially different skin protectants were applied to ex vivo pig skin, subjected to stresses, and the resulting skin was observed and analyzed. Using ex vivo pig skin, we sought to better understand the physical differences between a cyanoacrylate-based and a mixed cyanoacrylate/acrylic polymer-based skin protectant. A combination of imaging techniques and microscopic analyses was used to observe and quantify differences in layer thickness and the degree of steadfastness of the layers to liquid stresses. The experiments revealed that the solely cyanoacrylate-based protectant created a layer that was, on average, 5.1 times thicker than the mixed polymer product (p= 1.8 × 10). Observation via electron microscopy also revealed that the extent of coverage varied between the 2 products. In a final experiment, we observed that the mixed polymer product maintained a high degree of adhesiveness, which led to the removal of sheets of epithelium upon gentle blotting. The experiments revealed that while the 2 skin protectants share a common ingredient, both the quantity of that ingredient and the inclusion of other materials in one of them lead to substantially different properties when tested in the research setting.

Design and performance evaluation of collision protection-based safety operation for a haptic robot-assisted catheter operating system.

PubMed

Zhang, Linshuai; Guo, Shuxiang; Yu, Huadong; Song, Yu; Tamiya, Takashi; Hirata, Hideyuki; Ishihara, Hidenori

2018-02-23

The robot-assisted catheter system can increase operating distance thus preventing the exposure radiation of the surgeon to X-ray for endovascular catheterization. However, few designs have considered the collision protection between the catheter tip and the vessel wall. This paper presents a novel catheter operating system based on tissue protection to prevent vessel puncture caused by collision. The integrated haptic interface not only allows the operator to feel the real force feedback, but also combines with the newly proposed collision protection mechanism (CPM) to mitigate the collision trauma. The CPM can release the catheter quickly when the measured force exceeds a certain threshold, so as to avoid the vessel puncture. A significant advantage is that the proposed mechanism can adjust the protection threshold in real time by the current according to the actual characteristics of the blood vessel. To verify the effectiveness of the tissue protection by the system, the evaluation experiments in vitro were carried out. The results show that the further collision damage can be effectively prevented by the CPM, which implies the realization of relative safe catheterization. This research provides some insights into the functional improvements of safe and reliable robot-assisted catheter systems.

Re-imagining malaria: heterogeneity of human and mosquito behaviour in relation to residual malaria transmission in Cambodia.

PubMed

Gryseels, Charlotte; Durnez, Lies; Gerrets, René; Uk, Sambunny; Suon, Sokha; Set, Srun; Phoeuk, Pisen; Sluydts, Vincent; Heng, Somony; Sochantha, Tho; Coosemans, Marc; Peeters Grietens, Koen

2015-04-24

In certain regions in Southeast Asia, where malaria is reduced to forested regions populated by ethnic minorities dependent on slash-and-burn agriculture, malaria vector populations have developed a propensity to feed early and outdoors, limiting the effectiveness of long-lasting insecticide-treated nets (LLIN) and indoor residual spraying (IRS). The interplay between heterogeneous human, as well as mosquito behaviour, radically challenges malaria control in such residual transmission contexts. This study examines human behavioural patterns in relation to the vector behaviour. The anthropological research used a sequential mixed-methods study design in which quantitative survey research methods were used to complement findings from qualitative ethnographic research. The qualitative research existed of in-depth interviews and participant observation. For the entomological research, indoor and outdoor human landing collections were performed. All research was conducted in selected villages in Ratanakiri province, Cambodia. Variability in human behaviour resulted in variable exposure to outdoor and early biting vectors: (i) indigenous people were found to commute between farms in the forest, where malaria exposure is higher, and village homes; (ii) the indoor/outdoor biting distinction was less clear in forest housing often completely or partly open to the outside; (iii) reported sleeping times varied according to the context of economic activities, impacting on the proportion of infections that could be accounted for by early or nighttime biting; (iv) protection by LLINs may not be as high as self-reported survey data indicate, as observations showed around 40% (non-treated) market net use while (v) unprotected evening resting and deep forest activities impacted further on the suboptimal use of LLINs. The heterogeneity of human behaviour and the variation of vector densities and biting behaviours may lead to a considerable proportion of exposure occurring during times that people are assumed to be protected by the distributed LLINs. Additional efforts in improving LLIN use during times when people are resting in the evening and during the night might still have an impact on further reducing malaria transmission in Cambodia.

Survey of medical specialists on their attitudes to and resources for health research in Nigeria.

PubMed

Mahmoud, Abdulraheem O; Ayanniyi, Adeyinka A; Lawal, Abdul; Omolase, Charles O; Ologunsua, Yinka; Samaila, Elsie

2011-01-01

To study the views of medical specialists on their attitude to and the resources for health research in Nigeria and draw appropriate policy implications. Structured questionnaires were distributed to consenting 90 randomly selected medical specialists practising in six Nigerian tertiary health institutions. Participants' background information, importance attached to research, motivations for conducting research, funding, ethical oversight, literature search, and statistical support were probed. The coded responses were stored and analyzed using the statistical SPSS software. Fifty-one out of the 90 questionnaires distributed were returned, giving a response rate of 63.3%. Research function was rated third by 64.7% of the respondents after hospital service (72.5%) and teaching (66.0%). Advancement of knowledge was the strongest motivating factor for conducting research (78.4%). Securing funding (94%) and finding time (80%) were their major constraints. Only a minority of the respondents, 20% and 14%, respectfully, positively rated the quality and promptness of the decisions of their institutions' ethical organs in the highest category. Most of their literature search was conducted on the internet (96.1%) and they stored and analyzed their research data with commonly available statistical software. Our study respondents regarded research highly but were severely constrained in conducting research by lack of access to sources of funding from within and outside Nigeria and finding time from core hospital functions. We recommend periodic (re)training in research particularly on how to apply for research grants and giving some protected research time for Nigerian medical specialists in order to boost their research function.

A Pilot Study of the Validity of Self-reported Ultraviolet Radiation Exposure and Sun Protection Practices Among Lifeguards, Parents and Children

PubMed Central

O’Riordan, David L.; Glanz, Karen; Gies, Peter; Elliott, Tom

2013-01-01

Outdoor recreation settings, such as swimming pools, provide a promising venue to assess UVR exposure and sun protection practices among individuals who are minimally clothed and exposed to potentially high levels of UVR. Most studies assessing sun exposure/protection practices rely on self-reported data, which are subject to bias. The aim of this study was to establish the feasibility of conducting a multimethod study to examine the validity of self-reported measures within a swimming pool setting. Data were collected from 27 lifeguards, children and parents in Hawaii. Each participant filled out a survey and a 4 day sun habits diary. On two occasions, researchers assessed observable sun protection behaviors (wearing hats, shirts, sunglasses), swabbed the skin to detect the presence of sunscreen, and subjects wore polysulphone dosimeters to measure UVR exposure. Overall, observed sun protection behaviors were more highly correlated with diary reports than with survey reports. While lifeguards and children reported spending comparable amounts of time in the sun, dosimeter measures showed that lifeguards received twice as much UVR exposure. This study demonstrated the feasibility of implementing a multimethod validity study within a broader population of swimming pools. PMID:18179624

Barriers to conducting research: A survey of trainees in emergency medicine.

PubMed

Olaussen, Alexander; Jennings, Paul A; O'Reilly, Gerard; Mitra, Biswadev; Cameron, Peter A

2017-04-01

Research underpins evidence-based practice, but there are significant barriers to conducting research relevant to each clinical discipline. Understanding these barriers could allow strategies to reduce their impact. The present study was undertaken to understand specific barriers to research for emergency medicine (EM) trainees. EM trainees attending research short courses were surveyed. Free-text responses were classified into themes and a list of pre-specified potential barriers was used for ranking purposes. The responders (n = 61/90; 67.8%) were young, mostly male with low confidence in leading a research project and limited previous research experience. There were 155 unique barriers identified from 55 respondents, which fitted into nine categories. The most frequently perceived barrier was time (29%), followed by skills (22.6%) and cultural factors (19.4%). Most trainees (n = 54/56, 96.4%) believed that the barriers could be overcome. Strategies suggested included protection of time, mentoring and education, as well as top-down improved research culture. Barriers to research in EM are similar to other specialities and were perceived to be manageable. Reorganisation and refocus of the Australasian College for Emergency Medicine training curriculum may be an option to foster an environment to promote research. © 2017 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

The Status and Prospect of Research into Protective Structures of Bridge Piers against Rockfall Impact

NASA Astrophysics Data System (ADS)

Gao, Liang; Zhang, Shan; Zhang, Junfa; Wu, Xiangnan

2017-06-01

Rockfall impact on bridge piers threats severely the mountain bridge structures of lifeline engineering. Intended for mountain bridge pier protection against rockfall impact, the paper conducted comprehensive reviews on the research status of impact effects, anti-collision structure, impact response to rockfall, and protective design at home and abroad, and proposed a new-type protective structure against rockfall impact. In addition, the paper carried out deep studies on such key scientific issues as impact effect calculation, protective materials against rockfall impact, damage mechanism of protective units, and parameter optimization on the system of protective structures against rockfall impact as well, aiming to strength disaster prevention of mountain bridge structures.

When neonatal ICU infants participate in research: special protections for special subjects.

PubMed

Thomas, Karen A

2009-06-01

Neonatal ICU research poses unique concerns for infants and parents. Children are considered a vulnerable research population. Federal regulations specify special protections when children participate in research. These regulations determine the types of research approvable for children based on the balance of risks and benefit. Risk also determines whether one or both parents' consent is required for their infant's participation in research.

76 FR 12131 - Public Land Order No. 7759; Extension of Public Land Order No. 6833; Washington

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

... extension is necessary to continue to protect the unique natural and ecological research values of the... continue the protection of the unique natural and ecological research values at the Wolf Creek Research...

75 FR 36387 - Informational Public Meetings for Hydraulic Fracturing Research Study; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9168-2] Informational Public Meetings for Hydraulic Fracturing Research Study; Correction AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... of June 21, 2010, announcing public meetings for the Hydraulic Fracturing Research Study. The...

Implications of the 21st Century Cures Act for the Behavioral and Social Sciences at the National Institutes of Health.

PubMed

Riley, William T; Blizinsky, Katherine D

2017-06-01

The 21st Century Cures Act provides funding for key initiatives relevant to the behavioral and social sciences and includes administrative provisions that facilitate health research and increase the privacy protections of research participants. At about the same time as the passage of the Act, the National Institutes of Health Office of Behavioral and Social Sciences Research released its Strategic Plan 2017-2021, which addresses three scientific priorities: (a) improve the synergy of basic and applied behavioral and social sciences research; (b) enhance and promote the research infrastructure, methods, and measures needed to support a more cumulative and integrated approach to behavioral and social sciences; and (c) facilitate the adoption of behavioral and social sciences research findings in health research and in practice. This commentary describes the implications of the Cures Act on these scientific priorities and on the behavioral and social sciences more broadly.

Research ethics for a globalised world: the revised CIOMS international guidelines.

PubMed

Ehni, Hans-Jöerg; Wiesing, Urban

2017-01-01

On December 6, 2016, the Council of International Organisations of Medical Sciences published a new version of its guidelines with the title "International Ethical Guidelines for Health-related Research Involving Humans." In this article we briefly describe the revision process and the structure and content of these guidelines. We outline some of its main guidelines such as the ones on social value, post-trial access, and risk-benefit ratio. In our overall evaluation we come to the conclusion that the CIOMS guidelines manage to strike a balance between the protection of human participants in health-related research and the promotion of such research activities in an exemplary way. The guidelines combine key principles with a guide to their application based on the state of the art in research ethics. Thus they represent a timely and indispensable orientation for researchers, ethics committees, and other stakeholders in health-related research.

The Secure Medical Research Workspace: An IT Infrastructure to Enable Secure Research on Clinical Data

PubMed Central

Owen, Phillips; Mostafa, Javed; Lamm, Brent; Wang, Xiaoshu; Schmitt, Charles P.; Ahalt, Stanley C.

2013-01-01

Abstract Clinical data have tremendous value for translational research, but only if security and privacy concerns can be addressed satisfactorily. A collaboration of clinical and informatics teams, including RENCI, NC TraCS, UNC's School of Information and Library Science, Information Technology Service's Research Computing and other partners at the University of North Carolina at Chapel Hill have developed a system called the Secure Medical Research Workspace (SMRW) that enables researchers to use clinical data securely for research. SMRW significantly minimizes the risk presented when using identified clinical data, thereby protecting patients, researchers, and institutions associated with the data. The SMRW is built on a novel combination of virtualization and data leakage protection and can be combined with other protection methodologies and scaled to production levels. PMID:23751029

Progress in animal experimentation ethics: a case study from a Brazilian medical school and from the international medical literature.

PubMed

Ramalli, Edvaldo Luiz; Ho, Wanli; Alves, Mônica; Rocha, Eduardo Melani

2012-09-01

This study describes in Brazil and in the global biomedical community the time course of the development of animal research welfare guidelines. The database of the Ethics Committee of the Faculty of Medicine of Ribeirao Preto (EC/FMRP-USP), Brazil, was surveyed since its inception in 2002 as the regulations became more stringent to provide better protection of animal research welfare at this institution. Medline database was evaluated to identify the number of publications in the period between 1968 and 2008 that used research animals and were in compliance with established ethics guidelines. The EC/FMRP-USP evaluated 979 projects up until 2009. Most of the applications came from Department of Physiology and the most frequently requested species was the rat. In 2004, national research funding agencies started to request prior approval from institutional review ethics committees prior to application review and this requirement became federal law in Brazil in 2008. The analysis of international publications revealed a relative reduction in studies involving research animals (18% in 1968 to 7.5% in 2008). The present work showed that in the last four decades major changes occurred in the guidelines dictating use of research animals occurred and they are being adopted by developing countries. Moreover, animal welfare concern in the scientific community preceded the introduction of journal guidelines for this purpose. Furthermore, in Brazil it was anticipated that laws were needed to protect animal research welfare from being not upheld.

Mental health and hospital chaplaincy: strategies of self-protection (case study: toronto, Canada).

PubMed

Kianpour, Masoud

2013-01-01

This is a study about emotion management among a category of healthcare professional - hospital chaplains - who have hardly been the subject of sociological research about emotions. The aim of the study was to understand how chaplains manage their work-related emotions in order to protect their mental health, whilst also providing spiritual care. Using in-depth, semi structured interviews, the author spoke with 21 chaplains from five faith traditions (Christianity, Islam, Judaism, Buddhism and modern paganism) in different Toronto (Canada) Hospitals to see how they manage their emotion, and what resources they rely on in order to protect their mental health. Data analysis was perfumed according to Sandelowski's method of qualitative description. The average age and work experience of the subjects interviewed in this study are 52 and 9.6 respectively. 11 chaplains worked part-time and 10 chaplains worked full-time. 18 respondents were women and the sample incudes 3 male chaplains only. The findings are discussed, among others, according to the following themes: work-life balance, self-reflexivity, methods of self-care, and chaplains' emotional make-up. Emotion management per se is not a problem. However, if chaplains fail to maintain a proper work-life balance, job pressure can be harmful. As a strategy, many chaplains work part-time. As a supportive means, an overwhelming number of chaplains regularly benefit from psychotherapy and/or spiritual guidance. None.

Twitter weather warnings: Communicating risk in 140 characters-the impact of imperative and declarative message style on weather risk perception and behavioral intentions.

PubMed

Rainear, Adam M; Lachlan, Kenneth A; Spence, Patric R

Understanding how individuals utilize risk messages is important for protecting lives and gaining compliance toward safe behaviors. Recent advances in technology afford users with timeliness when needing to acquire information, and research investigating imperative and declarative message styles suggests utilizing both strategies is most effective. Similarly, the element of time can play a role when an individual engages in certain behaviors. This study employed an experimental design to better understand how imperative and declarative tweets, and time can contribute to risk perceptions and behavioral intentions. Results indicate the most negative affect is experienced after receiving an imperative-only tweet in a short-lead time condition, whereas a tweet utilizing both message styles in a long-lead time condition induces the most fear. Future research should investigate stylistic message elements on new media platforms to better understand how messages can be effectively sent and received by the intended audience within character-limited platforms.

Parenting Style as a Predictor of Adolescent Weight and Weight-Related Behaviors

PubMed Central

Berge, Jerica M.; Wall, Melanie; Loth, Katie; Neumark-Sztainer, Dianne

2009-01-01

Purpose: Current research indicates that specific parenting styles are associated with adolescent overweight, dietary intake and physical activity, but the majority of research has been cross-sectional making it difficult to determine the temporal order of these associations. The current study adds to the previous research by examining 5-year longitudinal associations between parenting style and adolescent weight and weight-related behaviors. Methods: Data from Project EAT, a population-based study with adolescents from diverse ethic and socioeconomic backgrounds were used. Adolescents (N = 2516) from 31 Minnesota schools completed in-class assessments in 1999 (Time 1) and mailed surveys in 2004 (Time 2). Multiple linear regression models were used to predict mean levels of adolescent outcomes at Time 2 from parenting style at Time 1. Results: Time 1 maternal authoritative parenting style predicted lower BMI in adolescent sons and daughters at Time 2. Time 1 paternal permissive parenting style predicted more fruits and vegetables intake in daughters at Time 2. Significant associations were not found between parenting style and adolescent physical activity. Conclusions: Findings suggest that authoritative parenting style may play a protective role related to adolescent overweight and that the dimension of warmth/caring in the parent/adolescent relationship may be important in relation to female adolescent healthy dietary intake. Further exploration of opposite sex parent/adolescent dyad patterns related to parenting style and adolescent weight and weight-related behaviors is warranted. PMID:20307821

SHARP Demonstration Flight: Video Broadcast System for Research in Intelligent Flight Characterization and Control

NASA Technical Reports Server (NTRS)

Kitts, Christopher

2001-01-01

The NASA Ames Research Center (Thermal Protection Materials and Systems Branch) is investigating new ceramic materials for the thermal protection of atmospheric entry vehicles. An incremental approach to proving the capabilities of these materials calls for a lifting entry flight test of a sharp leading edge component on the proposed SHARP (Slender Hypervelocity Aerothermodynamic Research Probe) vehicle. This flight test will establish the aerothermal performance constraint under real lifting entry conditions. NASA Ames has been developing the SHARP test flight with SSDL (responsible for the SHARP S I vehicle avionics), Montana State University (responsible for the SHARP S I vehicle airframe), the Wickman Spacecraft and Propulsion Company (responsible for the sounding rocket and launch operations), and with the SCU Intelligent Robotics Program, The SCU team was added well after the rest of the development team had formed. The SCU role was to assist with the development of a real-time video broadcast system which would relay onboard flight video to a communication groundstation. The SCU team would also assist with general vehicle preparation as well as flight operations. At the time of the submission of the original SCU proposal, a test flight in Wyoming was originally targeted for September 2000. This date was moved several times into the Fall of 2000. It was then postponed until the Spring of 2001, and later pushed into late Summer 2001. To date, the flight has still not taken place. These project delays resulted in SCU requesting several no-cost extensions to the project. Based on the most recent conversations with the project technical lead, Paul Kolodjiez, the current plan is for the overall SHARP team to assemble what exists of the vehicle, to document the system, and to 'mothball' the vehicle in anticipation of future flight and funding opportunities.

Developing Privacy Solutions for Sharing and Analyzing Healthcare Data

PubMed Central

Motiwalla, Luvai; Li, Xiao-Bai

2013-01-01

The extensive use of electronic health data has increased privacy concerns. While most healthcare organizations are conscientious in protecting their data in their databases, very few organizations take enough precautions to protect data that is shared with third party organizations. Recently the regulatory environment has tightened the laws to enforce privacy protection. The goal of this research is to explore the application of data masking solutions for protecting patient privacy when data is shared with external organizations for research, analysis and other similar purposes. Specifically, this research project develops a system that protects data without removing sensitive attributes. Our application allows high quality data analysis with the masked data. Dataset-level properties and statistics remain approximately the same after data masking; however, individual record-level values are altered to prevent privacy disclosure. A pilot evaluation study on large real-world healthcare data shows the effectiveness of our solution in privacy protection. PMID:24285983

45 CFR 46.109 - IRB review of research.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false IRB review of research. 46.109 Section 46.109 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.109 IRB review of research. (a) An...

45 CFR 46.109 - IRB review of research.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false IRB review of research. 46.109 Section 46.109 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.109 IRB review of research. (a) An...

45 CFR 46.109 - IRB review of research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false IRB review of research. 46.109 Section 46.109 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.109 IRB review of research. (a) An...

34 CFR 97.109 - IRB review of research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false IRB review of research. 97.109 Section 97.109 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.109 IRB review of research. (a) An IRB shall review and have authority to approve, require modifications in (to...

34 CFR 97.109 - IRB review of research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false IRB review of research. 97.109 Section 97.109 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.109 IRB review of research. (a) An IRB shall review and have authority to approve, require modifications in (to...

40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

Code of Federal Regulations, 2013 CFR

2013-07-01

... observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.303 Duties of IRBs in connection with observational research involving pregnant women...

40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

Code of Federal Regulations, 2012 CFR

2012-07-01

... observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.303 Duties of IRBs in connection with observational research involving pregnant women...

40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

Code of Federal Regulations, 2010 CFR

2010-07-01

... observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.303 Duties of IRBs in connection with observational research involving pregnant women...

40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

Code of Federal Regulations, 2011 CFR

2011-07-01

... observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.303 Duties of IRBs in connection with observational research involving pregnant women...

40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

Code of Federal Regulations, 2014 CFR

2014-07-01

... observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment... Protections for Pregnant Women and Fetuses Involved as Subjects in Observational Research Conducted or Supported by EPA § 26.303 Duties of IRBs in connection with observational research involving pregnant women...

34 CFR 97.111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... possible long-range effects of applying knowledge gained in the research (for example, the possible effects... 34 Education 1 2010-07-01 2010-07-01 false Criteria for IRB approval of research. 97.111 Section... Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research...

40 CFR 26.111 - Criteria for IRB approval of research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... possible long-range effects of applying knowledge gained in the research (for example, the possible effects... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Criteria for IRB approval of research... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by...

40 CFR 26.1125 - Prior submission of proposed human research for EPA review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... research for EPA review. 26.1125 Section 26.1125 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of: (1) The potential risks to human subjects; (2) The measures proposed to minimize risks to the... through the proposed research; and (5) The balance of risks and benefits of the proposed research. (b) All...

76 FR 5735 - Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... pregnant women and for children who are the subjects of observational research conducted or supported by... whether human testing is necessary given other methods of research. E. Settlement of the Litigation After... Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides AGENCY...

40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation of...