DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiltsev, Vladimir

The 2014 P5 report indicated the accelerator-based neutrino and rare decay physics research as a centerpiece of the US domestic HEP program. Operation, upgrade and development of the accelerators for the near-term and longer-term particle physics program at the Intensity Frontier face formidable challenges. Here we discuss key elements of the accelerator physics and technology R&D program toward future multi-MW proton accelerators.

Distant protonated pyridine groups in water-soluble iron porphyrin electrocatalysts promote selective oxygen reduction to water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matson, Benjamin D.; Carver, Colin T.; Von Ruden, Amber L.

2012-11-08

Fe(III)-meso-tetra(pyridyl)porphines are selective electrocatalysts for the reduction of dioxygen to water in aqueous acidic solution. The 2-pyridyl derivatives, both the triflate and chloride salts, are more selective than the isomeric 4-pyridyl complexes. The improved selectivity of is ascribed to the inward-pointing pyridinium groups acting as intramolecular proton relays. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science. Pacific Northwest National Laboratory is operated by Battelle for the US Department of Energy.

Theoretical insights of proton transfer and hydrogen bonded charge transfer complex of 1,2-dimethylimidazolium-3,5-dinitrobenzoate crystal

NASA Astrophysics Data System (ADS)

Afroz, Ziya; Faizan, Mohd.; Alam, Mohammad Jane; Ahmad, Shabbir; Ahmad, Afaq

2018-04-01

Proton transfer (PT) and hydrogen bonded charge transfer (HBCT) 1:1 complex of 1,2-dimethylimidazole (DMI) and 3,5-dinitrobenzoic acid (DNBA) have been theoretically analyzed and compared with reported experimental results. Both the structures in the isolated gaseous state have been optimized at DFT/B3LYP/6-311G(d,p) level of theory and further, the PT energy barrier has been calculated from potential energy surface scan. Along with structural investigations, theoretical vibrational spectra have been inspected and compared with the FTIR spectrum. Moreover, frontier molecular analysis has also been carried out.

Characterization and Modeling of a Water-based Liquid Scintillator

DOE PAGES

L. J. Bignell; Beznosko, D.; Diwan, M. V.; ...

2015-12-15

We characterised Water-based Liquid Scintillator (WbLS) using low energy protons, UV-VIS absorbance, and fluorescence spectroscopy. We have also developed and validated a simulation model that describes the behaviour of WbLS in our detector configurations for proton beam energies of 210 MeV, 475 MeV, and 2 GeV and for two WbLS compositions. These results have enabled us to estimate the light yield and ionisation quenching of WbLS, as well as to understand the influence of the wavelength shifting of Cherenkov light on our measurements. These results are relevant to the suitability of WbLS materials for next generation intensity frontier experiments.

US Frontiers of Engineering Symposia

DTIC Science & Technology

2015-02-01

Dr . Kristi Anseth, Distinguished Professor of Chemical and Biological Engineering and HHMI Assistant Investigator at the University of Colorado...speech was given by Dr . Alan I. Taub, professor of materials science and engineering at the University of Michigan, Report Documentation Page Form...at the Hotel du Pont in Wilmington, Delaware. Dr . Kristi Anseth, Distinguished Professor of Chemical and Biological Engineering and HHMI Assistant

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments.

PubMed

He, Lu; Friedman, Alan M; Bailey-Kellogg, Chris

2012-03-01

In developing improved protein variants by site-directed mutagenesis or recombination, there are often competing objectives that must be considered in designing an experiment (selecting mutations or breakpoints): stability versus novelty, affinity versus specificity, activity versus immunogenicity, and so forth. Pareto optimal experimental designs make the best trade-offs between competing objectives. Such designs are not "dominated"; that is, no other design is better than a Pareto optimal design for one objective without being worse for another objective. Our goal is to produce all the Pareto optimal designs (the Pareto frontier), to characterize the trade-offs and suggest designs most worth considering, but to avoid explicitly considering the large number of dominated designs. To do so, we develop a divide-and-conquer algorithm, Protein Engineering Pareto FRontier (PEPFR), that hierarchically subdivides the objective space, using appropriate dynamic programming or integer programming methods to optimize designs in different regions. This divide-and-conquer approach is efficient in that the number of divisions (and thus calls to the optimizer) is directly proportional to the number of Pareto optimal designs. We demonstrate PEPFR with three protein engineering case studies: site-directed recombination for stability and diversity via dynamic programming, site-directed mutagenesis of interacting proteins for affinity and specificity via integer programming, and site-directed mutagenesis of a therapeutic protein for activity and immunogenicity via integer programming. We show that PEPFR is able to effectively produce all the Pareto optimal designs, discovering many more designs than previous methods. The characterization of the Pareto frontier provides additional insights into the local stability of design choices as well as global trends leading to trade-offs between competing criteria. Copyright © 2011 Wiley Periodicals, Inc.

Preface: Special Topic on Frontiers in Molecular Scale Electronics

NASA Astrophysics Data System (ADS)

Evers, Ferdinand; Venkataraman, Latha

2017-03-01

The electronic, mechanical, and thermoelectric properties of molecular scale devices have fascinated scientists across several disciplines in natural sciences and engineering. The interest is partially technological, driven by the fast miniaturization of integrated circuits that now have reached characteristic features at the nanometer scale. Equally important, a very strong incentive also exists to elucidate the fundamental aspects of structure-function relations for nanoscale devices, which utilize molecular building blocks as functional units. Thus motivated, a rich research field has established itself, broadly termed "Molecular Electronics," that hosts a plethora of activities devoted to this goal in chemistry, physics, and electrical engineering. This Special Topic on Frontiers of Molecular Scale Electronics captures recent theoretical and experimental advances in the field.

New frontiers in H-Beta auroral photometry

NASA Astrophysics Data System (ADS)

Unick, C.; Donovan, E.; Connors, M. G.; Spanswick, E.; Jackel, B. J.; Greffen, M. J.; Wilson, C.; Little, J.; Chaddock, D.; Schofield, I.; MacRae, A.; Chen, S.; Crowther, A.; James, S.; Read, A.; Willis, T.

2013-12-01

The proton aurora provides valuable information about magnetotail structure and dynamics. For example, the location of the equatorward boundary of the proton aurora is a robust indicator of magnetotail stretching. Also, proton auroral luminosities combined with in situ ion measurements provide important information about magnetic mapping between the inner CPS and the auroral ionosphere. In this paper, we present a new and innovative proton-auroral (H-Beta) meridian-scanning photometer (MSP) capable of higher spatial and temporal resolution than has been achieved in the past. This H-Beta MSP is the first of a new dual-wavelength (signal/background) MSP design with a single scanning mirror and no other moving parts. The novel filtering architecture allows for a near 100% duty cycle with a 30-second meridian scan and configurable operating modes. The new design is significantly more sensitive than the legacy CANOPUS MSPs. The increased SNR can be employed in a variety of ways, such as to achieve significantly higher time resolution. Here, we present the new instrument design, test data from a commissioning campaign in Athabasca, and some thoughts on how the enhance proton auroral capability can increase the science value of these measurements.

Enhanced critical currents of commercial 2G superconducting coated conductors through proton irradiation

NASA Astrophysics Data System (ADS)

Welp, Ulrich; Leroux, M.; Kihlstrom, K. J.; Kwok, W.-K.; Koshelev, A. E.; Miller, D. J.; Rupich, M. W.; Fleshler, S.; Malozemoff, A. P.; Kayani, A.

2015-03-01

We report on magnetization and transport measurements of the critical current density, Jc, of commercial 2G YBCO coated conductors before and after proton irradiation. The samples were irradiated along the c-axis with 4 MeV protons. Proton irradiation produces a mixed pinning landscape composed of pre-existing rare earth particles and a uniform distribution of irradiation induced nm-sized defects. This pinning landscape strongly reduces the suppression of Jc in magnetic fields resulting in a doubling of Jc in a field of ~ 4T. The irradiation dose-dependence of Jc is characterized by a temperature and field dependent sweat spot that at 5 K and 6 T occurs around 20x1016 p/cm2. Large-scale time dependent Ginzburg-Landau simulations yield a good description of our results. This work supported by the Center for Emergent Superconductivity, an Energy Frontier Research Center funded by the U.S. D.O.E., Office of Science, Office of Basic Energy Sciences (KK, ML, AEK) and by the D.O.E, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357 (UW, WKK).

Science Educators Teaching Engineering Design: An Examination across Science Professional Development Sites

ERIC Educational Resources Information Center

Grubbs, Michael E.; Love, Tyler S.; Long, David E.; Kittrell, Danielle

2016-01-01

Although the currently employed STEM (science, technology, engineering, and mathematics) acronym is of recent origin, dating to the early 2000s (Chute, 2009), the United States has long emphasized the importance of teaching STEM in its public schools. Early efforts, such as "Science, the Endless Frontier" (Bush, 1945) and the…

Moving beyond Frontiers: How Institutional Context Affects Degree Production and Student Aspirations in STEM

ERIC Educational Resources Information Center

Eagan, Mark Kevin, Jr.

2010-01-01

Colleges and universities in the U.S. face increasing pressure from policymakers and corporate leaders to increase their production of undergraduate degrees in science, technology, engineering, and mathematics (STEM). These pressures stem from a need to maintain the country's global economic competitiveness in science and engineering innovation.…

Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium

DTIC Science & Technology

2009-07-07

article, we review recent progress on a highly 61 ROLL PRINTING OF CRYSTALliNE NANOWIRES efficient, scalable approach for the ordered, unifonn...NATIONAL ACADEMIES Advisers to the Nation on Science, Engineering, and Medicine The National Academy of Sciences is a private, nonprofit, self...target delivery of a therapy to a particular physiological system, minimizing systemic side effects. Talks in the session provided an overview of

Proton Radiography of Spontaneous Fields, Plasma Flows and Dynamics in X-Ray Driven Inertial-Confinement Fusion Implosions

NASA Astrophysics Data System (ADS)

Li, C. K.; Seguin, F. H.; Frenje, J. A.; Rosenberg, M.; Zylstra, A. B.; Rinderknecht, H. G.; Petrasso, R. D.; Amendt, P. A.; Landen, O. L.; Town, R. P. J.; Betti, R.; Knauer, J. P.; Meyerhofer, D. D.; Back, C. A.; Kilkenny, J. D.; Nikroo, A.

2010-11-01

Backlighting of x-ray-driven implosions in empty hohlraums with mono-energetic protons on the OMEGA laser facility has allowed a number of important phenomena to be observed. Several critical parameters were determined, including plasma flow, three types of spontaneous electric fields and megaGauss magnetic fields. These results provide insight into important issues in indirect-drive ICF. Even though the cavity is effectively a Faraday cage, the strong, local fields inside the hohlraum can affect laser-plasma instabilities, electron distributions and implosion symmetry. They are of fundamental scientific importance for a range of new experiments at the frontiers of high-energy-density physics. Future experiments designed to characterize the field formation and evolution in low-Z gas fill hohlraums will be discussed.

Ultrafast Intramolecular Electron and Proton Transfer in Bis(imino)isoindole Derivatives.

PubMed

Driscoll, Eric; Sorenson, Shayne; Dawlaty, Jahan M

2015-06-04

Concerted motion of electrons and protons in the excited state is pertinent to a wide range of chemical phenomena, including those relevant for solar-to-fuel light harvesting. The excited state dynamics of small proton-bearing molecules are expected to serve as models for better understanding such phenomena. In particular, for designing the next generation of multielectron and multiproton redox catalysts, understanding the dynamics of more than one proton in the excited state is important. Toward this goal, we have measured the ultrafast dynamics of intramolecular excited state proton transfer in a recently synthesized dye with two equivalent transferable protons. We have used a visible ultrafast pump to initiate the proton transfer in the excited state, and have probed the transient absorption of the molecule over a wide bandwidth in the visible range. The measurement shows that the signal which is characteristic of proton transfer emerges within ∼710 fs. To identify whether both protons were transferred in the excited state, we have measured the ultrafast dynamics of a related derivative, where only a single proton was available for transfer. The measured proton transfer time in that molecule was ∼427 fs. The observed dynamics in both cases were reasonably fit with single exponentials. Supported by the ultrafast observations, steady-state fluorescence, and preliminary computations of the relaxed excited states, we argue that the doubly protonated derivative most likely transfers only one of its two protons in the excited state. We have performed calculations of the frontier molecular orbitals in the Franck-Condon region. The calculations show that in both derivatives, the excitation is primarily from the HOMO to LUMO causing a large rearrangement of the electronic charge density immediately after photoexcitation. In particular, charge density is shifted away from the phenolic protons and toward the proton acceptor nitrogens. The proton transfer is hypothesized to occur both due to enhanced acidity of the phenolic proton and enhanced basicity of the nitrogen in the excited state. We hope this study can provide insight for better understanding of the general class of excited state concerted electron-proton dynamics.

Synthesis and Electronic Properties of Fluoreno[2,1-a]fluorenedione and Fluoreno[1,2-a]fluorenedione.

PubMed

Hacker, Allison S; Pavano, Mauricio; Wood, James E; Immoos, Chad E; Hashimoto, Hannah; Genis, Sam P; Frantz, Derik K

2018-01-05

The [2,1-a]- and [1,2-a]-isomers of fluorenofluorenedione have been synthesized via intramolecular Friedel-Crafts acylations. DFT calculations indicate that the [1,2-a]-isomer adopts a twisted, helical C 2 -symmetric structure and that its protonated form is the thermodynamic product of the Friedel-Crafts acylation in hot sulfuric acid. Absorption spectroscopy and cyclic voltammetry measurements provide experimental estimations of frontier molecular orbital energy levels, which are reported and discussed.

Composite electrolyte with proton conductivity for low-temperature solid oxide fuel cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raza, Rizwan, E-mail: razahussaini786@gmail.com; Department of Energy Technology, Royal Institute of Technology, KTH, Stockholm 10044; Ahmed, Akhlaq

In the present work, cost-effective nanocomposite electrolyte (Ba-SDC) oxide is developed for efficient low-temperature solid oxide fuel cells (LTSOFCs). Analysis has shown that dual phase conduction of O{sup −2} (oxygen ions) and H{sup +} (protons) plays a significant role in the development of advanced LTSOFCs. Comparatively high proton ion conductivity (0.19 s/cm) for LTSOFCs was achieved at low temperature (460 °C). In this article, the ionic conduction behaviour of LTSOFCs is explained by carrying out electrochemical impedance spectroscopy measurements. Further, the phase and structure analysis are investigated by X-ray diffraction and scanning electron microscopy techniques. Finally, we achieved an ionic transport numbermore » of the composite electrolyte for LTSOFCs as high as 0.95 and energy and power density of 90% and 550 mW/cm{sup 2}, respectively, after sintering the composite electrolyte at 800 °C for 4 h, which is promising. Our current effort toward the development of an efficient, green, low-temperature solid oxide fuel cell with the incorporation of high proton conductivity composite electrolyte may open frontiers in the fields of energy and fuel cell technology.« less

Production of Hydrogen by Electrocatalysis: Making the H-H Bond by Combining Protons and Hydrides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bullock, R. Morris; Appel, Aaron M.; Helm, Monte L.

2014-03-25

Generation of hydrogen by reduction of two protons by two electrons can be catalysed by molecular electrocatalysts. Determination of the thermodynamic driving force for elimination of H2 from molecular complexes is important for the rational design of molecular electrocatalysts, and allows the design of metal complexes of abundant, inexpensive metals rather than precious metals (“Cheap Metals for Noble Tasks”). The rate of H2 evolution can be dramatically accelerated by incorporating pendant amines into diphosphine ligands. These pendant amines in the second coordination sphere function as protons relays, accelerating intramolecular and intermolecular proton transfer reactions. The thermodynamics of hydride transfer frommore » metal hydrides and the acidity of protonated pendant amines (pKa of N-H) contribute to the thermodynamics of elimination of H2; both of the hydricity and acidity can be systematically varied by changing the substituents on the ligands. A series of Ni(II) electrocatalysts with pendant amines have been developed. In addition to the thermochemical considerations, the catalytic rate is strongly influenced by the ability to deliver protons to the correct location of the pendant amine. Protonation of the amine endo to the metal leads to the N-H being positioned appropriately to favor rapid heterocoupling with the M-H. Designing ligands that include proton relays that are properly positioned and thermodynamically tuned is a key principle for molecular electrocatalysts for H2 production as well as for other multi-proton, multi-electron reactions important for energy conversions. The research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for DOE.« less

Nonadiabatic rate constants for proton transfer and proton-coupled electron transfer reactions in solution: Effects of quadratic term in the vibronic coupling expansion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soudackov, Alexander; Hammes-Schiffer, Sharon

2015-11-17

Rate constant expressions for vibronically nonadiabatic proton transfer and proton-coupled electron transfer reactions are presented and analyzed. The regimes covered include electronically adiabatic and nonadiabatic reactions, as well as high-frequency and low-frequency regimes for the proton donor-acceptor vibrational mode. These rate constants differ from previous rate constants derived with the cumulant expansion approach in that the logarithmic expansion of the vibronic coupling in terms of the proton donor-acceptor distance includes a quadratic as well as a linear term. The analysis illustrates that inclusion of this quadratic term does not significantly impact the rate constants derived using the cumulant expansion approachmore » in any of the regimes studied. The effects of the quadratic term may become significant when using the vibronic coupling expansion in conjunction with a thermal averaging procedure for calculating the rate constant, however, particularly at high temperatures and for proton transfer interfaces with extremely soft proton donor-acceptor modes that are associated with extraordinarily weak hydrogen bonds. Even with the thermal averaging procedure, the effects of the quadratic term for weak hydrogen-bonding systems are less significant for more physically realistic models that prevent the sampling of unphysical short proton donor-acceptor distances, and the expansion of the coupling can be avoided entirely by calculating the couplings explicitly for the range of proton donor-acceptor distances. This analysis identifies the regimes in which each rate constant expression is valid and thus will be important for future applications to proton transfer and proton-coupled electron transfer in chemical and biological processes. We are grateful for support from National Institutes of Health Grant GM056207 (applications to enzymes) and the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences (applications to molecular electrocatalysts).« less

The European Microkelvin Platform

NASA Astrophysics Data System (ADS)

Pickett, George; Enss, Christian

2018-03-01

The growing demands of quantum materials, engineering and technology make access to microkelvin temperatures ever more essential. Experience in Europe suggests that new working methods, encouraged by an imaginative funding atmosphere, can accelerate progress in this frontier field.

Pioneers on the Astrosociological Frontier: Introduction to the First Symposium on Astrosociology

NASA Astrophysics Data System (ADS)

Pass, Jim

2009-03-01

Astrosociology is a relatively new multidisciplinary field that scientifically investigates astrosocial phenomena (i.e., social, cultural, and behavioral patterns related to space exploration and related issues). The "astrosociological frontier" represents an analogous framework to that of space as the "final frontier," as both territories are quite empty of human activity and ripe for exploration. This focus on the astrosociological frontier provides insights about the need for a social-scientific field to place the human dimension in its proper place alongside familiar space community concerns such as engineering. The astrosociological frontier refers to the lack of development of astrosociology as a scientific field—or anything like it earlier during the space age. It includes both the 1) unoccupied "landscape" in academia characterized by the lack of astrosociology in its curricula and 2) dearth of space research focused on social-scientific (i.e., astrosociological) topics both inside and outside of traditional academia in collaboration with traditional space community members and the new space entrepreneurs. Within academia, the "frontier" is characterized by a lack of courses, programs, and departments dedicated to astrosociology. In the future, proponents of this new field expect the astrosociological frontier to become characterized by a growing number of "settlements" in curricula across the country and world. As things stand, however, the early "astrosociological pioneers" include those who seek to explore these underappreciated issues within academic and professional climates that discourage them from pursuing their interests. Thus, the "1st Symposium on Astrosociology" at the 2009 SPESIF conference represents an important expedition consisting of pioneering participants willing to venture into a little-explored territory with the goal of developing astrosociology.

A Brain-Based Communication and Orientation System

DTIC Science & Technology

2014-10-06

Review of the BCI Competition IV, Frontiers in Neuroscience, ( 2012): 0. doi: 10.3389/fnins.2012.00055 Eric C. Leuthardt, Xiao-Mei Pei, Jonathan...hardware and software for brain– computer interfaces ( BCIs ), Journal of Neural Engineering, (04 2011): 1. doi: 10.1088/1741-2560/8/2/025001...Cincotti, G. Schalk, Peter Brunner. Current Trends in Brain–Computer Interface ( BCI ) Research and Development, Journal of Neural Engineering, (3 2011

Protonation-modulated localization of excess electrons in histidine aqueous solutions revealed by ab initio molecular dynamics simulations: anion-centered versus cation-centered localization.

PubMed

Gao, Liang; Bu, Yuxiang

2017-05-31

In this work, we present an ab initio molecular dynamics simulation study on the interaction of an excess electron (EE) with histidine in its aqueous solution. Two different configurations of histidine (imidazole group protonated or not) are considered to reflect its different existing forms in neutral or slightly acidic surroundings. The simulation results indicate that localizations of EEs in different aqueous histidine solutions are quite different and are strongly affected by protonation of the side chain imidazole group and are thus pH-controlled. In neutral aqueous histidine solution, an EE localizes onto the carboxyl anionic group of the amino acid backbone after a relatively lengthy diffuse state, performing just like in an aliphatic amino acid solution. But in weakly acidic solution in which the side chain imidazole group is protonated, an EE undergoes a short lifetime diffuse state and finally localizes on the protonated imidazole group. We carefully examine these two different localization dynamics processes and analyze the competition between different dominating groups in their corresponding electron localization mechanisms. To explain the difference, we investigate the frontier molecular orbitals of these two systems and find that their energy levels and compositions are important to determine these differences. These findings can provide helpful information to understand the interaction mechanisms of low energy EEs with amino acids and even oligopeptides, especially with aromatic rings.

Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites

DOE PAGES

Sutherlin, Kyle D.; Liu, Lei V.; Lee, Yong-Min; ...

2016-11-02

Fe III-(hydro)peroxy intermediates have been isolated in two classes of mononuclear nonheme Fe enzymes that are important in bioremediation: the Rieske dioxygenases and the extradiol dioxygenases. The binding mode and protonation state of the peroxide moieties in these intermediates are not well-defined, due to a lack of vibrational structural data. Nuclear resonance vibrational spectroscopy (NRVS) is an important technique for obtaining vibrational information on these and other intermediates, as it is sensitive to all normal modes with Fe displacement. Here in this paper, we present the NRVS spectra of side-on Fe III-peroxy and end-on Fe III-hydroperoxy model complexes and assignmore » these spectra using calibrated DFT calculations. We then use DFT calculations to define and understand the changes in the NRVS spectra that arise from protonation and from opening the Fe–O–O angle. This study identifies four spectroscopic handles that will enable definition of the binding mode and protonation state of Fe III-peroxy intermediates in mononuclear nonheme Fe enzymes. These structural differences are important in determining the frontier molecular orbitals available for reactivity.« less

Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutherlin, Kyle D.; Liu, Lei V.; Lee, Yong-Min

Fe III-(hydro)peroxy intermediates have been isolated in two classes of mononuclear nonheme Fe enzymes that are important in bioremediation: the Rieske dioxygenases and the extradiol dioxygenases. The binding mode and protonation state of the peroxide moieties in these intermediates are not well-defined, due to a lack of vibrational structural data. Nuclear resonance vibrational spectroscopy (NRVS) is an important technique for obtaining vibrational information on these and other intermediates, as it is sensitive to all normal modes with Fe displacement. Here in this paper, we present the NRVS spectra of side-on Fe III-peroxy and end-on Fe III-hydroperoxy model complexes and assignmore » these spectra using calibrated DFT calculations. We then use DFT calculations to define and understand the changes in the NRVS spectra that arise from protonation and from opening the Fe–O–O angle. This study identifies four spectroscopic handles that will enable definition of the binding mode and protonation state of Fe III-peroxy intermediates in mononuclear nonheme Fe enzymes. These structural differences are important in determining the frontier molecular orbitals available for reactivity.« less

Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites.

PubMed

Sutherlin, Kyle D; Liu, Lei V; Lee, Yong-Min; Kwak, Yeonju; Yoda, Yoshitaka; Saito, Makina; Kurokuzu, Masayuki; Kobayashi, Yasuhiro; Seto, Makoto; Que, Lawrence; Nam, Wonwoo; Solomon, Edward I

2016-11-02

Fe III -(hydro)peroxy intermediates have been isolated in two classes of mononuclear nonheme Fe enzymes that are important in bioremediation: the Rieske dioxygenases and the extradiol dioxygenases. The binding mode and protonation state of the peroxide moieties in these intermediates are not well-defined, due to a lack of vibrational structural data. Nuclear resonance vibrational spectroscopy (NRVS) is an important technique for obtaining vibrational information on these and other intermediates, as it is sensitive to all normal modes with Fe displacement. Here, we present the NRVS spectra of side-on Fe III -peroxy and end-on Fe III -hydroperoxy model complexes and assign these spectra using calibrated DFT calculations. We then use DFT calculations to define and understand the changes in the NRVS spectra that arise from protonation and from opening the Fe-O-O angle. This study identifies four spectroscopic handles that will enable definition of the binding mode and protonation state of Fe III -peroxy intermediates in mononuclear nonheme Fe enzymes. These structural differences are important in determining the frontier molecular orbitals available for reactivity.

Electrochemical Detection of Transient Cobalt Hydride Intermediates of Electrocatalytic Hydrogen Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiedner, Eric S.; Bullock, R. Morris

2016-07-06

We report the use of variable scan rate cyclic voltammetry to detect transient CoIIIH and CoIIH intermediates of electrocatalytic H2 production by CoII(dmgBF2)2(CH3CN)2 and [CoII(PtBu2NPh2)(CH3CN)3]2+. In both cases, reduction of the CoIIIH intermediate was observed to coincide with the CoII/I couple, and the resulting CoIIH intermediate is protonated by acid to afford H2. Our studies indicate that in electrocatalytic H2 production, protonation of CoIIH is rate-limiting for CoII(dmgBF2)2(CH3CN)2, and protonation of CoI is rate-limiting for [CoII(PtBu2NPh2)(CH3CN)3]2+. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy,more » Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

Careers in Oceanography.

ERIC Educational Resources Information Center

Hollister, Charles D., Ed.

This booklet was prepared by practicing oceanographers to help college students in their search for professional direction. The booklet: (1) points out some frontiers of current research; (2) describes five major subfields of oceanography (marine geology and geophysics, oceanographic engineering, physical oceanography, chemical oceanography, and…

Evolving a Method to Capture Science Stakeholder Inputs to Optimize Instrument, Payload, and Program Design

NASA Astrophysics Data System (ADS)

Clark, P. E.; Rilee, M. L.; Curtis, S. A.; Bailin, S.

2012-03-01

We are developing Frontier, a highly adaptable, stably reconfigurable, web-accessible intelligent decision engine capable of optimizing design as well as the simulating operation of complex systems in response to evolving needs and environment.

Fermilab proton accelerator complex status and improvement plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiltsev, Vladimir

2017-05-30

Fermilab carries out an extensive program of accelerator-based high energy particle physics research at the Intensity Frontier that relies on the operation of 8 GeV and 120 GeV proton beamlines for a n umber of fixed target experiments. Routine operation with a world-record 700kW of average 120 GeV beam power on the neutrino target was achieved in 2017 as the result of the Proton Improvement Plan (PIP) upgrade. There are plans to further increase the power to 900 – 1000 kW. The next major upgrade of the FNAL accelerator complex, called PIP-II, is under development. It aims at 1.2MW beammore » power on target at the start of the LBNF/DUNE experiment in the middle of the next decade and assumes replacement of the existing 40-years old 400 MeV normal-conducting Linac with a modern 800 MeV superconducting RF linear accelerator. There are several concepts to further double the beam power to >2.4MW after replacement of the existing 8 GeV Booster synchrotron. In this article we discuss current performance of the Fermilab proton accelerator complex, the upgrade plans for the next two decades and the accelerator R&D program to address cost and performance risks for these upgrades.« less

TDDFT study on the sensing mechanism of a fluorescent sensor for fluoride anion: Inhibition of the ESPT process.

PubMed

Li, Guang-Yue; Liu, Dong; Zhang, Hang; Li, Wei-Wei; Wang, Feng; Liang, Ying-Hua

2015-01-01

The fluoride-sensing mechanism of a reported salicylaldehyde-based sensor (J. Photochem. Photobiol. B 2014, 138, 75) has been investigated by the TDDFT method. The present theoretical study indicates that there is an excited-state proton transfer (ESPT) process from the phenolic O-H moiety to the neighbor N atom in the sensor. The added fluoride anion could capture the proton in the O-H moiety and the corresponding phenolic anion is formed, which could inhibit the ESPT process. The experimental UV/Vis and fluorescence spectra are well reproduced by the calculated vertical excitation energies. Frontier molecular orbital analysis indicates that the local excited state of phenolic anion is responsible for its enhanced fluorescence. Due to this reason, the sensor can be used to sense fluoride anion by monitoring the fluorescent change. Copyright © 2015 Elsevier B.V. All rights reserved.

University of Arizona High Energy Physics Program at the Cosmic Frontier 2014-2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

abate, alex; cheu, elliott

This is the final technical report from the University of Arizona High Energy Physics program at the Cosmic Frontier covering the period 2014-2016. The work aims to advance the understanding of dark energy using the Large Synoptic Survey Telescope (LSST). Progress on the engineering design of the power supplies for the LSST camera is discussed. A variety of contributions to photometric redshift measurement uncertainties were studied. The effect of the intergalactic medium on the photometric redshift of very distant galaxies was evaluated. Computer code was developed realizing the full chain of calculations needed to accurately and efficiently run large-scale simulations.

Combined Spectroscopic and Electrochemical Detection of a NiI•••H–N Bonding Interaction with Relevance to Electrocatalytic H2 Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kochem, Amelie; O'Hagan, Molly J.; Wiedner, Eric S.

2015-07-13

The [Ni(PR2NR’2)2]2+ family of complexes are exceptionally active catalysts for proton reduction to H2. In this manuscript, we explore the first protonation step of the proposed catalytic cycle by using a catalytically inactive NiI complex possessing a sterically demanding variation of the ligand. Due to the paramagnetic nature of the NiI oxidation state, the protonated NiI intermediate has been characterized through a combination of cyclic voltammetry, ENDOR, and HYSCORE spectroscopy. Both the electrochemical and spectroscopic studies indicate that the NiI complex is protonated at a pendant amine that is endo to Ni, which suggests the presence of an intramolecular NiI•••HNmore » bonding interaction. Using density functional theory, the proton was found to hydrogen bond to three doubly-occupied, localized molecular orbitals: the 3dxz, 3dz2, and 3dyz orbitals of nickel. These studies provide the first direct experimental evidence for this critical catalytic intermediate, and implications for catalytic H2 production are discussed. Research was supported by the Max Planck Society (EPR, ENDOR, and HYSCORE spectroscopy, computational studies), and as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the US Department of Energy (DOE), Office of Science, Office of Basic Energy Sciences (electrochemistry, NMR spectroscopy). Pacific Northwest National Laboratory is operated by Battelle for DOE.« less

SU-E-T-120: Analytic Dose Verification for Patient-Specific Proton Pencil Beam Scanning Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, C; Mah, D

2015-06-15

Purpose: To independently verify the QA dose of proton pencil beam scanning (PBS) plans using an analytic dose calculation model. Methods: An independent proton dose calculation engine is created using the same commissioning measurements as those employed to build our commercially available treatment planning system (TPS). Each proton PBS plan is exported from the TPS in DICOM format and calculated by this independent dose engine in a standard 40 x 40 x 40 cm water tank. This three-dimensional dose grid is then compared with the QA dose calculated by the commercial TPS, using standard Gamma criterion. A total of 18more » measured pristine Bragg peaks, ranging from 100 to 226 MeV, are used in the model. Intermediate proton energies are interpolated. Similarly, optical properties of the spots are measured in air over 15 cm upstream and downstream, and fitted to a second-order polynomial. Multiple Coulomb scattering in water is approximated analytically using Preston and Kohler formula for faster calculation. The effect of range shifters on spot size is modeled with generalized Highland formula. Note that the above formulation approximates multiple Coulomb scattering in water and we therefore chose not use the full Moliere/Hanson form. Results: Initial examination of 3 patient-specific prostate PBS plans shows that agreement exists between 3D dose distributions calculated by the TPS and the independent proton PBS dose calculation engine. Both calculated dose distributions are compared with actual measurements at three different depths per beam and good agreements are again observed. Conclusion: Results here showed that 3D dose distributions calculated by this independent proton PBS dose engine are in good agreement with both TPS calculations and actual measurements. This tool can potentially be used to reduce the amount of different measurement depths required for patient-specific proton PBS QA.« less

Transportation: The Key to Unlocking the Final Frontier

NASA Technical Reports Server (NTRS)

Sackheim, Robert L.; Saucier, Sidney (Technical Monitor)

2000-01-01

For this future generations in this new millennium, only two new frontiers remain to be explored and developed by humans: Under the oceans, seas and lakes (about 80 percent of the Earth) and The vast reaches of near and outer space. We are slowly running out of resources while this planet's population is exploding. We must establish new, highly reliable and low-cost ways to colonize under the seas and to get people permanently off "Spaceship Planet Earth". We must establish new colonies permanently in space because it is vital to the ultimate survival of the human race. Reliable and affordable space transportation for routine human travel into space and the planets is once again the key to developing this last great frontier. This talk will now focus on what NASA is now doing to initiate the process in earnest. Space transportation is the key, and once again will only meet the needs with new generations of competent, talented, and innovative mechanical engineers.

Future Tense: Science Fiction Confronts the New Science.

ERIC Educational Resources Information Center

Antczak, Janice

1990-01-01

Describes 10 science fiction stories for young readers whose contents address recent developments on the frontiers of scientific research, including genetic engineering, artificial intelligence, and robotics. The use of these materials to inform young readers about the issues and dangers involved in scientific developments is discussed. (CLB)

Enhancement of Survival and Electricity Production in an Engineered Bacterium by Light-Driven Proton Pumping▿ †

PubMed Central

Johnson, Ethan T.; Baron, Daniel B.; Naranjo, Belén; Bond, Daniel R.; Schmidt-Dannert, Claudia; Gralnick, Jeffrey A.

2010-01-01

Microorganisms can use complex photosystems or light-dependent proton pumps to generate membrane potential and/or reduce electron carriers to support growth. The discovery that proteorhodopsin is a light-dependent proton pump that can be expressed readily in recombinant bacteria enables development of new strategies to probe microbial physiology and to engineer microbes with new light-driven properties. Here, we describe functional expression of proteorhodopsin and light-induced changes in membrane potential in the bacterium Shewanella oneidensis strain MR-1. We report that there were significant increases in electrical current generation during illumination of electrochemical chambers containing S. oneidensis expressing proteorhodopsin. We present evidence that an engineered strain is able to consume lactate at an increased rate when it is illuminated, which is consistent with the hypothesis that proteorhodopsin activity enhances lactate uptake by increasing the proton motive force. Our results demonstrate that there is coupling of a light-driven process to electricity generation in a nonphotosynthetic engineered bacterium. Expression of proteorhodopsin also preserved the viability of the bacterium under nutrient-limited conditions, providing evidence that fulfillment of basic energy needs of organisms may explain the widespread distribution of proteorhodopsin in marine environments. PMID:20453141

Enhancement of survival and electricity production in an engineered bacterium by light-driven proton pumping.

PubMed

Johnson, Ethan T; Baron, Daniel B; Naranjo, Belén; Bond, Daniel R; Schmidt-Dannert, Claudia; Gralnick, Jeffrey A

2010-07-01

Microorganisms can use complex photosystems or light-dependent proton pumps to generate membrane potential and/or reduce electron carriers to support growth. The discovery that proteorhodopsin is a light-dependent proton pump that can be expressed readily in recombinant bacteria enables development of new strategies to probe microbial physiology and to engineer microbes with new light-driven properties. Here, we describe functional expression of proteorhodopsin and light-induced changes in membrane potential in the bacterium Shewanella oneidensis strain MR-1. We report that there were significant increases in electrical current generation during illumination of electrochemical chambers containing S. oneidensis expressing proteorhodopsin. We present evidence that an engineered strain is able to consume lactate at an increased rate when it is illuminated, which is consistent with the hypothesis that proteorhodopsin activity enhances lactate uptake by increasing the proton motive force. Our results demonstrate that there is coupling of a light-driven process to electricity generation in a nonphotosynthetic engineered bacterium. Expression of proteorhodopsin also preserved the viability of the bacterium under nutrient-limited conditions, providing evidence that fulfillment of basic energy needs of organisms may explain the widespread distribution of proteorhodopsin in marine environments.

Accelerator physics and technology challenges of very high energy hadron colliders

DOE PAGES

Shiltsev, Vladimir D.

2015-08-20

High energy hadron colliders have been in the forefront of particle physics for more than three decades. At present, international particle physics community considers several options for a 100 TeV proton–proton collider as a possible post-LHC energy frontier facility. The method of colliding beams has not fully exhausted its potential but has slowed down considerably in its progress. This article briefly reviews the accelerator physics and technology challenges of the future very high energy colliders and outlines the areas of required research and development towards their technical and financial feasibility.

Electrochemical energy engineering: a new frontier of chemical engineering innovation.

PubMed

Gu, Shuang; Xu, Bingjun; Yan, Yushan

2014-01-01

One of the grand challenges facing humanity today is a safe, clean, and sustainable energy system where combustion no longer dominates. This review proposes that electrochemical energy conversion could set the foundation for such an energy system. It further suggests that a simple switch from an acid to a base membrane coupled with innovative cell designs may lead to a new era of affordable electrochemical devices, including fuel cells, electrolyzers, solar hydrogen generators, and redox flow batteries, for which recent progress is discussed using the authors' work as examples. It also notes that electrochemical energy engineering will likely become a vibrant subdiscipline of chemical engineering and a fertile ground for chemical engineering innovation. To realize this vision, it is necessary to incorporate fundamental electrochemistry and electrochemical engineering principles into the chemical engineering curriculum.

33 CFR 209.200 - Regulations governing navigable waters.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Commander, Western Sea Frontier. (3) The authority to prescribe danger zone regulations must be... the application. (f) Public hearings. (1) It is the policy of the Chief of Engineers to conduct his civil works activities in an atmosphere of public understanding, trust, and mutual cooperation and in a...

Annual symposium on Frontiers in Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Metzger, N.; Fulton, K.R.

This final report summarizes activities conducted for the National Academy of Sciences' Annual Symposium on Frontiers of Science with support from the US Department of Energy for the period July 1, 1993 through May 31, 1998. During the report period, five Frontiers of Science symposia were held at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering. For each Symposium, an organizing committee appointed by the NAS President selected and planned the eight sessions for the Symposium and identified general participants for invitation by the NAS President. These Symposia accomplished their goal of bringing togethermore » outstanding younger (age 45 or less) scientists to hear presentations in disciplines outside their own and to discuss exciting advances and opportunities in their fields in a format that encourages, and allows adequate time for, informal one-on-one discussions among participants. Of the 458 younger scientists who participated, over a quarter (124) were women. Participant lists for all symposia (1993--1997) are attached. The scientific participants were leaders in basic research from academic, industrial, and federal laboratories in such disciplines as astronomy, astrophysics, atmospheric science, biochemistry, cell biology, chemistry, computer science, earth sciences, engineering, genetics, material sciences, mathematics, microbiology, neuroscience, physics, and physiology. For each symposia, the 24 speakers and discussants on the program were urged to focus their presentations on current cutting-edge research in their field for a scientifically sophisticated but non-specialist audience, and to provide a sense of the experimental data--what is actually measured and seen in the various fields. They were also asked to address questions such as: What are the major research problems and unique tools in their field? What are the current limitations on advances as well as the frontiers? Speakers were asked to provide a 2500- to 3000-word synopsis of their speech in advance, so that participants, particularly those in other fields, could familiarize themselves with the topic.« less

Advanced engineering and biomimetic materials for bone repair and regeneration

NASA Astrophysics Data System (ADS)

Yang, Lei; Zhong, Chao

2013-12-01

Over the past decade, there has been tremendous progress in developing advanced biomaterials for tissue repair and regeneration. This article reviews the frontiers of this field from two closely related areas, new engineering materials for bone substitution and biomimetic mineralization for bone-like nanocomposites. Rather than providing an exhaustive overview of the literature, we focus on several representative directions. We also discuss likely future trends in these areas, including synthetic biology-enabled biomaterials design and multifunctional implant materials for bone repair and regeneration.

Beam Induced Hydrodynamic Tunneling in the Future Circular Collider Components

NASA Astrophysics Data System (ADS)

Tahir, N. A.; Burkart, F.; Schmidt, R.; Shutov, A.; Wollmann, D.; Piriz, A. R.

2016-08-01

A future circular collider (FCC) has been proposed as a post-Large Hadron Collider accelerator, to explore particle physics in unprecedented energy ranges. The FCC is a circular collider in a tunnel with a circumference of 80-100 km. The FCC study puts an emphasis on proton-proton high-energy and electron-positron high-intensity frontier machines. A proton-electron interaction scenario is also examined. According to the nominal FCC parameters, each of the 50 TeV proton beams will carry an amount of 8.5 GJ energy that is equivalent to the kinetic energy of an Airbus A380 (560 t) at a typical speed of 850 km /h . Safety of operation with such extremely energetic beams is an important issue, as off-nominal beam loss can cause serious damage to the accelerator and detector components with a severe impact on the accelerator environment. In order to estimate the consequences of an accident with the full beam accidently deflected into equipment, we have carried out numerical simulations of interaction of a FCC beam with a solid copper target using an energy-deposition code (fluka) and a 2D hydrodynamic code (big2) iteratively. These simulations show that, although the penetration length of a single FCC proton and its shower in solid copper is about 1.5 m, the full FCC beam will penetrate up to about 350 m into the target because of the "hydrodynamic tunneling." These simulations also show that a significant part of the target is converted into high-energy-density matter. We also discuss this interesting aspect of this study.

Spectroscopic study of 2-, 4- and 5-substituents on p Ka values of imidazole heterocycles prone to intramolecular proton-electrons transfer

NASA Astrophysics Data System (ADS)

Eseola, Abiodun O.; Obi-Egbedi, Nelson O.

2010-02-01

New 2-(1H-imidazol-2-yl)phenols ( L1Et- L8tBuPt) bearing a phenolic proton in the vicinity of the imidazole base were prepared and characterized. Experimental studies of the dependence of their protonation/deprotonation equilibrium on substituent identities and intramolecular hydrogen bonding tendencies were carried out using electronic absorption spectroscopy at varying pH values. In order to make comparison, 2-(anthracen-10-yl)-4,5-diphenyl-1H-imidazole ( L9Anthr) bearing no phenolic proton and 4,5-diphenyl-2-(4,5-diphenyl-1H-imidazol-2-yl)-1H-imidazole ( L10BisIm) bearing two symmetrical imidazole base fragments were also prepared and experimentally investigated. DFT calculations were carried out to study frontier orbitals of the investigated molecules. While electron-releasing substituents produced increase in protonation-deprotonation p Kas for the hydroxyl group, values for the imidazole base were mainly affected by polarization of the imidazole ring aromaticity across the 2-imidazole carbon and the 4,5-imidazole carbons axis of the imidazole ring. It was concluded that electron-releasing substituents on the phenol ring and/or electron-withdrawing substituents on 4,5-imidazole carbons negatively affects donor strengths/coordination chemistries of 2-(1H-imidazol-2-yl)phenols, and vice versa. Change of substituents on the phenol ring significantly altered the donor strength of the imidazole base. The understanding of p Ka variation on account of electronic effects of substituents in this work should aid the understanding of biochemical properties and substituent environments of imidazole-containing biomacromolecules.

Power to the People...Energy for Now and Later

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sung, Chih-Jen; Law, Chung K; Brady, Kyle

Representing the Combustion Energy Frontier Research Center (CEFRC), this document is one of the entries in the Ten Hundred and One Word Challenge. As part of the challenge, the 46 Energy Frontier Research Centers were invited to represent their science in images, cartoons, photos, words and original paintings, but any descriptions or words could only use the 1000 most commonly used words in the English language, with the addition of one word important to each of the EFRCs and the mission of DOE: energy. The mission of CEFRC is to develop a validated, predictive, multi-scale combusion modeling capacity which canmore » be used to optimize the design and operation of evolving fuels in advanced engines for transportation applications.« less

The Wondrous New World of Modern Particle Astrophysics

ERIC Educational Resources Information Center

Hallin, Aksel; Hallman, Doug

2009-01-01

To investigate the frontiers of particle physics, physicists and engineers are building detectors and making measurements in unusual settings from outer space to far-flung regions of the Earth. In the past several decades, laboratories have been set up deep underground in working mines or mountain tunnels to look at subatomic particles from our…

Climate Change and Evolution of Vector Associated Pathogens: Potential to Increase or Decrease Duration and Intensity of Epidemics

USDA-ARS?s Scientific Manuscript database

Population growth, frontier agricultural expansion, and urbanization transform the landscape and the surrounding ecosystem, affecting climate, diseases, and interactions between animals and humans. Additionally, the Earth’s oceans serve as the engine of the Earth’s climate and ecosystems, and they a...

NAS Decadal Review Town Hall

NASA Astrophysics Data System (ADS)

The National Academies of Sciences, Engineering and Medicine is seeking community input for a study on the future of materials research (MR). Frontiers of Materials Research: A Decadal Survey will look at defining the frontiers of materials research ranging from traditional materials science and engineering to condensed matter physics. Please join members of the study committee for a town hall to discuss future directions for materials research in the United States in the context of worldwide efforts. In particular, input on the following topics will be of great value: progress, achievements, and principal changes in the R&D landscape over the past decade; identification of key MR areas that have major scientific gaps or offer promising investment opportunities from 2020-2030; and the challenges that MR may face over the next decade and how those challenges might be addressed. This study was requested by the Department of Energy and the National Science Foundation. The National Academies will issue a report in 2018 that will offer guidance to federal agencies that support materials research, science policymakers, and researchers in materials research and other adjoining fields. Learn more about the study at http://nas.edu/materials.

Stereoscopic construction and practice of optoelectronic technology textbook

NASA Astrophysics Data System (ADS)

Zhou, Zigang; Zhang, Jinlong; Wang, Huili; Yang, Yongjia; Han, Yanling

2017-08-01

It is a professional degree course textbook for the Nation-class Specialty—Optoelectronic Information Science and Engineering, and it is also an engineering practice textbook for the cultivation of photoelectric excellent engineers. The book seeks to comprehensively introduce the theoretical and applied basis of optoelectronic technology, and it's closely linked to the current development of optoelectronic industry frontier and made up of following core contents, including the laser source, the light's transmission, modulation, detection, imaging and display. At the same time, it also embodies the features of the source of laser, the transmission of the waveguide, the electronic means and the optical processing methods.

New Frontiers AO: Advanced Materials Bi-propellant Rocket (AMBR) Engine Information Summary

NASA Technical Reports Server (NTRS)

Liou, Larry C.

2008-01-01

The Advanced Material Bi-propellant Rocket (AMBR) engine is a high performance (I(sub sp)), higher thrust, radiation cooled, storable bi-propellant space engine of the same physical envelope as the High Performance Apogee Thruster (HiPAT(TradeMark)). To provide further information about the AMBR engine, this document provides details on performance, development, mission implementation, key spacecraft integration considerations, project participants and approach, contact information, system specifications, and a list of references. The In-Space Propulsion Technology (ISPT) project team at NASA Glenn Research Center (GRC) leads the technology development of the AMBR engine. Their NASA partners were Marshall Space Flight Center (MSFC) and Jet Propulsion Laboratory (JPL). Aerojet leads the industrial partners selected competitively for the technology development via the NASA Research Announcement (NRA) process.

Pericyte-targeting drug delivery and tissue engineering.

PubMed

Kang, Eunah; Shin, Jong Wook

2016-01-01

Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes.

Meanings and Policy Implications of "Transformative Research": Frontiers, Hot Science, Evolution, and Investment Risk

ERIC Educational Resources Information Center

Dietz, James S.; Rogers, Juan D.

2012-01-01

In recent times there has been a surge in interest on policy instruments to stimulate scientific and engineering research that is of greater consequence, advancing our knowledge in leaps rather than steps and is therefore more "creative" or, in the language of recent reports, "transformative." Associated with the language of "transformative…

America's Space Program: Exploring a New Frontier. Teaching with Historic Places.

ERIC Educational Resources Information Center

Koman, Rita G.

Several hundred thousand people converged on the Kennedy Space Center (Florida) on July 16, 1969, to view the launch of the "Saturn V" rocket that would propel "Apollo 11" to the moon. The engineers and technicians watching their computer screens may secretly have kept their fingers crossed, but at two minutes before launch, a…

The Role of Engineering Skills in Development

ERIC Educational Resources Information Center

DeBoer, Jennifer Jean

2012-01-01

A young child dreams of being an astronaut. She dreams of piloting a complex rocket full of buttons and gadgets through the sky and discovering new planets in the unknown, unchartered universe of scientific frontiers. As the child grows, she makes her way through the sacred halls of formal schooling. She takes classes, goes to college, and starts…

Synthetic Morphogenesis.

PubMed

Teague, Brian P; Guye, Patrick; Weiss, Ron

2016-09-01

Throughout biology, function is intimately linked with form. Across scales ranging from subcellular to multiorganismal, the identity and organization of a biological structure's subunits dictate its properties. The field of molecular morphogenesis has traditionally been concerned with describing these links, decoding the molecular mechanisms that give rise to the shape and structure of cells, tissues, organs, and organisms. Recent advances in synthetic biology promise unprecedented control over these molecular mechanisms; this opens the path to not just probing morphogenesis but directing it. This review explores several frontiers in the nascent field of synthetic morphogenesis, including programmable tissues and organs, synthetic biomaterials and programmable matter, and engineering complex morphogenic systems de novo. We will discuss each frontier's objectives, current approaches, constraints and challenges, and future potential. Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

Metabolic Engineering VII Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kevin Korpics

The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniquesmore » important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.« less

Nano-regenerative medicine towards clinical outcome of stem cell and tissue engineering in humans

PubMed Central

Arora, Pooja; Sindhu, Annu; Dilbaghi, Neeraj; Chaudhury, Ashok; Rajakumar, Govindasamy; Rahuman, Abdul Abdul

2012-01-01

Nanotechnology is a fast growing area of research that aims to create nanomaterials or nanostructures development in stem cell and tissue-based therapies. Concepts and discoveries from the fields of bio nano research provide exciting opportunities of using stem cells for regeneration of tissues and organs. The application of nanotechnology to stem-cell biology would be able to address the challenges of disease therapeutics. This review covers the potential of nanotechnology approaches towards regenerative medicine. Furthermore, it focuses on current aspects of stem- and tissue-cell engineering. The magnetic nanoparticles-based applications in stem-cell research open new frontiers in cell and tissue engineering. PMID:22260258

Proposal and Research Direction of Soil Mass Organic Reorganization

NASA Astrophysics Data System (ADS)

Zhang, Lu; Han, Jichang

2018-01-01

Land engineering as a new discipline has been temporarily outrageous. The proposition of soil body organic reorganization undoubtedly enriches the research content for the construction of land engineering disciplines. Soil body organic reconstruction is designed to study how to realize the ecological ecology of the land by studying the external force of nature, to study the influence of sunlight, wind and water on soil body, how to improve the soil physical structure, to further strengthen the research of biological enzymes and microbes, and promote the release and utilization of beneficial inert elements in soil body. The emerging of frontier scientific research issues with soil body organic reorganization to indicate directions for the future development of soil engineering.

Biomimetic strategies for engineering composite tissues.

PubMed

Lee, Nancy; Robinson, Jennifer; Lu, Helen

2016-08-01

The formation of multiple tissue types and their integration into composite tissue units presents a frontier challenge in regenerative engineering. Tissue-tissue synchrony is crucial in providing structural support for internal organs and enabling daily activities. This review highlights the state-of-the-art in composite tissue scaffold design, and explores how biomimicry can be strategically applied to avoid over-engineering the scaffold. Given the complexity of biological tissues, determining the most relevant parameters for recapitulating native structure-function relationships through strategic biomimicry will reduce the burden for clinical translation. It is anticipated that these exciting efforts in composite tissue engineering will enable integrative and functional repair of common soft tissue injuries and lay the foundation for total joint or limb regeneration. Copyright © 2016 Elsevier Ltd. All rights reserved.

Wireless Sensor Network Radio Power Management and Simulation Models

DTIC Science & Technology

2010-01-01

The Open Electrical & Electronic Engineering Journal, 2010, 4, 21-31 21 1874-1290/10 2010 Bentham Open Open Access Wireless Sensor Network Radio...Air Force Institute of Technology, Wright-Patterson AFB, OH, USA Abstract: Wireless sensor networks (WSNs) create a new frontier in collecting and...consumption. Keywords: Wireless sensor network , power management, energy-efficiency, medium access control (MAC), simulation pa- rameters. 1

Semiconductors: Still a Wide Open Frontier for Scientists/Engineers

NASA Astrophysics Data System (ADS)

Seiler, David G.

1997-10-01

A 1995 Business Week article described several features of the explosive use of semiconductor chips today: ``Booming'' personal computer markets are driving high demand for microprocessors and memory chips; (2) New information superhighway markets will `ignite' sales of multimedia and communication chips; and (3) Demand for digital-signal-processing and data-compression chips, which speed up video and graphics, is `red hot.' A Washington Post article by Stan Hinden said that technology is creating an unstoppable demand for electronic elements. This ``digital pervasiveness'' means that a semiconductor chip is going into almost every high-tech product that people buy - cars, televisions, video recorders, telephones, radios, alarm clocks, coffee pots, etc. ``Semiconductors are everywhere.'' Silicon and compound semiconductors are absolutely essential and are pervasive enablers for DoD operations and systems. DoD's Critical Technologies Plan of 1991 says that ``Semiconductor materials and microelectronics are critically important and appropriately lead the list of critical defense technologies.'' These trends continue unabated. This talk describes some of the frontiers of semiconductors today and shows how scientists and engineers can effectively contribute to its advancement. Cooperative, multidisciplinary efforts are increasing. Specific examples will be given for scanning capacitance microscopy and thin-film metrology.

Nanofluid two-phase flow and thermal physics: a new research frontier of nanotechnology and its challenges.

PubMed

Cheng, Lixin; Bandarra Filho, Enio P; Thome, John R

2008-07-01

Nanofluids are a new class of fluids engineered by dispersing nanometer-size solid particles in base fluids. As a new research frontier, nanofluid two-phase flow and thermal physics have the potential to improve heat transfer and energy efficiency in thermal management systems for many applications, such as microelectronics, power electronics, transportation, nuclear engineering, heat pipes, refrigeration, air-conditioning and heat pump systems. So far, the study of nanofluid two-phase flow and thermal physics is still in its infancy. This field of research provides many opportunities to study new frontiers but also poses great challenges. To summarize the current status of research in this newly developing interdisciplinary field and to identify the future research needs as well, this paper focuses on presenting a comprehensive review of nucleate pool boiling, flow boiling, critical heat flux, condensation and two-phase flow of nanofluids. Even for the limited studies done so far, there are some controversies. Conclusions and contradictions on the available nanofluid studies on physical properties, two-phase flow, heat transfer and critical heat flux (CHF) are presented. Based on a comprehensive analysis, it has been realized that the physical properties of nanofluids such as surface tension, liquid thermal conductivity, viscosity and density have significant effects on the nanofluid two-phase flow and heat transfer characteristics but the lack of the accurate knowledge of these physical properties has greatly limited the study in this interdisciplinary field. Therefore, effort should be made to contribute to the physical property database of nanofluids as a first priority. Secondly, in particular, research on nanofluid two-phase flow and heat transfer in microchannels should be emphasized in the future.

Singlet-catalyzed electroweak phase transitions in the 100 TeV frontier

NASA Astrophysics Data System (ADS)

Kotwal, Ashutosh V.; Ramsey-Musolf, Michael J.; No, Jose Miguel; Winslow, Peter

2016-08-01

We study the prospects for probing a gauge singlet scalar-driven strong first-order electroweak phase transition with a future proton-proton collider in the 100 TeV range. Singlet-Higgs mixing enables resonantly enhanced di-Higgs production, potentially aiding discovery prospects. We perform Monte Carlo scans of the parameter space to identify regions associated with a strong first-order electroweak phase transition, analyze the corresponding di-Higgs signal, and select a set of benchmark points that span the range of di-Higgs signal strengths. For the b b ¯γ γ and 4 τ final states, we investigate discovery prospects for each benchmark point for the high-luminosity phase of the Large Hadron Collider and for a future p p collider with √{s }=50 , 100, or 200 TeV. We find that any of these future collider scenarios could significantly extend the reach beyond that of the high-luminosity LHC, and that with √{s }=100 TeV (200 TeV) and 30 ab-1 , the full region of parameter space favorable to strong first-order electroweak phase transitions is almost fully (fully) discoverable.

Experimental and quantum chemical studies of a new organic proton transfer compound, 1H-imidazole-3-ium-3-hydroxy-2,4,6-trinitrophenolate

NASA Astrophysics Data System (ADS)

Dhamodharan, P.; Sathya, K.; Dhandapani, M.

2018-02-01

A new proton transfer compound, 1H-imidazole-3-ium-3-hydroxy-2,4,6-trinitrophenolate (IMHTP), was crystallized by slow evaporation-solution growth technique. 1H and 13C NMR spectral studies confirm the molecular structure of the grown crystal. Single crystal X-ray diffraction study confirms that IMHTP crystallizes in monoclinic system with space group P21/c. Thermal curves (TG/DTA) show that the material is thermally stable up to 198 °C. The crystal emits fluorescence at 510 nm, proving its utility in making green light emitting materials in optical applications. The stable molecular structure was optimized by Gaussian 09 program with B3LYP/6-311++G(d,p) level of basis set. The frontier molecular orbital study shows that the charge transfer interaction occurs within the complex. The calculated first-order hyperpolarizability value of IMHTP is 44 times higher than that the reference material, urea. The electrostatic potential map was used to probe into electrophilic and nucleophilic reactive sites present in the molecule.

Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.

PubMed

Reinert, Zachary E; Horne, W Seth

2014-11-28

A variety of non-biological structural motifs have been incorporated into the backbone of natural protein sequences. In parallel work, diverse unnatural oligomers of de novo design (termed "foldamers") have been developed that fold in defined ways. In this Perspective article, we survey foundational studies on protein backbone engineering, with a focus on alterations made in the context of complex tertiary folds. We go on to summarize recent work illustrating the potential promise of these methods to provide a general framework for the construction of foldamer mimics of protein tertiary structures.

Advances in bionanomaterials for bone tissue engineering.

PubMed

Scott, Timothy G; Blackburn, Gary; Ashley, Michael; Bayer, Ilker S; Ghosh, Anindya; Biris, Alexandru S; Biswas, Abhijit

2013-01-01

Bone is a specialized form of connective tissue that forms the skeleton of the body and is built at the nano and microscale levels as a multi-component composite material consisting of a hard inorganic phase (minerals) in an elastic, dense organic network. Mimicking bone structure and its properties present an important frontier in the fields of nanotechnology, materials science and bone tissue engineering, given the complex morphology of this tissue. There has been a growing interest in developing artificial bone-mimetic nanomaterials with controllable mineral content, nanostructure, chemistry for bone, cartilage tissue engineering and substitutes. This review describes recent advances in bionanomaterials for bone tissue engineering including developments in soft tissue engineering. The significance and basic process of bone tissue engineering along with different bionanomaterial bone scaffolds made of nanocomposites and nanostructured biopolymers/bioceramics and the prerequisite biomechanical functions are described. It also covers latest developments in soft-tissue reconstruction and replacement. Finally, perspectives on the future direction in nanotechnology-enabled bone tissue engineering are presented.

Leadership in Space: Selected Speeches of NASA Administrator Michael Griffin, May 2005 - October 2008

NASA Technical Reports Server (NTRS)

Griffin, Michael

2008-01-01

Speech topics include: Leadership in Space; Space Exploration: Real and Acceptable Reasons; Why Explore Space?; Space Exploration: Filling up the Canvas; Continuing the Voyage: The Spirit of Endeavour; Incorporating Space into Our Economic Sphere of Influence; The Role of Space Exploration in the Global Economy; Partnership in Space Activities; International Space Cooperation; National Strategy and the Civil Space Program; What the Hubble Space Telescope Teaches Us about Ourselves; The Rocket Team; NASA's Direction; Science and NASA; Science Priorities and Program Management; NASA and the Commercial Space Industry; NASA and the Business of Space; American Competitiveness: NASA's Role & Everyone's Responsibility; Space Exploration: A Frontier for American Collaboration; The Next Generation of Engineers; System Engineering and the "Two Cultures" of Engineering; Generalship of Engineering; NASA and Engineering Integrity; The Constellation Architecture; Then and Now: Fifty Years in Space; The Reality of Tomorrow; and Human Space Exploration: The Next 50 Years.

Quantum entanglement and spin control in silicon nanocrystal.

PubMed

Berec, Vesna

2012-01-01

Selective coherence control and electrically mediated exchange coupling of single electron spin between triplet and singlet states using numerically derived optimal control of proton pulses is demonstrated. We obtained spatial confinement below size of the Bohr radius for proton spin chain FWHM. Precise manipulation of individual spins and polarization of electron spin states are analyzed via proton induced emission and controlled population of energy shells in pure (29)Si nanocrystal. Entangled quantum states of channeled proton trajectories are mapped in transverse and angular phase space of (29)Si <100> axial channel alignment in order to avoid transversal excitations. Proton density and proton energy as impact parameter functions are characterized in single particle density matrix via discretization of diagonal and nearest off-diagonal elements. We combined high field and low densities (1 MeV/92 nm) to create inseparable quantum state by superimposing the hyperpolarizationed proton spin chain with electron spin of (29)Si. Quantum discretization of density of states (DOS) was performed by the Monte Carlo simulation method using numerical solutions of proton equations of motion. Distribution of gaussian coherent states is obtained by continuous modulation of individual spin phase and amplitude. Obtained results allow precise engineering and faithful mapping of spin states. This would provide the effective quantum key distribution (QKD) and transmission of quantum information over remote distances between quantum memory centers for scalable quantum communication network. Furthermore, obtained results give insights in application of channeled protons subatomic microscopy as a complete versatile scanning-probe system capable of both quantum engineering of charged particle states and characterization of quantum states below diffraction limit linear and in-depth resolution.PACS NUMBERS: 03.65.Ud, 03.67.Bg, 61.85.+p, 67.30.hj.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Hugh H.; Balasubramanian, V.; Bernstein, G.

The University of Pennsylvania elementary particle physics/particle cosmology group, funded by the Department of Energy Office of Science, participates in research in high energy physics and particle cosmology that addresses some of the most important unanswered questions in science. The research is divided into five areas. Energy Frontier - We participate in the study of proton-proton collisions at the Large Hadron Collider in Geneva, Switzerland using the ATLAS detector. The University of Pennsylvania group was responsible for the design, installation, and commissioning of the front-end electronics for the Transition Radiation Tracker (TRT) and plays the primary role in its maintenancemore » and operation. We play an important role in the triggering of ATLAS, and we have made large contributions to the TRT performance and to the study and identification of electrons, photons, and taus. We have been actively involved in searches for the Higgs boson and for SUSY and other exotic particles. We have made significant contributions to measurement of Standard Model processes such as inclusive photon production and WW pair production. We also have participated significantly in R&D for upgrades to the ATLAS detector. Cosmic Frontier - The Dark Energy Survey (DES) telescope will be used to elucidate the nature of dark energy and the distribution of dark matter. Penn has played a leading role both in the use of weak gravitational lensing of distant galaxies and the discovery of large numbers of distant supernovae. The techniques and forecasts developed at Penn are also guiding the development of the proposed Large Synoptic Survey Telescope (LSST).We are also developing a new detector, MiniClean, to search for direct detection of dark matter particles. Intensity Frontier - We are participating in the design and R&D of detectors for the Long Baseline Neutrino Experiment (now DUNE), a new experiment to study the properties of neutrinos. Advanced Techology R&D - We have an extensive involvement in electronics required for sophisticated new detectors at the LHC and are developing electronics for the LSST camera. Theoretical Physics - We are carrying out a broad program studying the fundamental forces of nature and early universe cosmology and mathematical physics. Our activities span the range from model building, formal field theory, and string theory to new paradigms for cosmology and the interface of string theory with mathematics. Our effort combines extensive development of the formal aspects of string theory with a focus on real phenomena in particle physics, cosmology and gravity.« less

X-15: Extending the Frontiers of Flight

NASA Technical Reports Server (NTRS)

Jenkins, Dennis R.

2007-01-01

A history of the design and achievements of the high-speed, 1950s-era X-15 airplane is presented. The following chapters are included: A New Science; A Hypersonic Research Airplane; Conflict and Innovation; The Million-Horsepower Engine; High Range and Dry Lakes; Preparations; The Flight Program; and the Research Program. Selected biographies, flight logs and physical characteristics of the X-15 Airplane are included in the appendices.

Frontiers in Learning. The Association of Higher Education Facilities Officers Educational Conference and Annual Meeting Proceedings (83rd, Salt Lake City, Utah, July 21-23, 1996).

ERIC Educational Resources Information Center

APPA: Association of Higher Education Facilities Officers, Alexandria, VA.

These 25 papers from a conference of higher education facilities offices are grouped into 5 categories: business management; energy and environment; human resources; operations and maintenance; and planning, design and construction. Papers are: (1) "Provider of Choice" (Jerry C. Black); (2) "Re-Engineering--'Inside-Inside' or Outside-Inside': A…

Practical Radiobiology for Proton Therapy Planning

NASA Astrophysics Data System (ADS)

Jones, Bleddyn

2017-12-01

Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear descriptions of useful equations for high LET particle beam applications, worked examples of many important clinical situations, and discussion of how proton therapy may be optimized are all important features of the text. This important book blends the relevant physics, biology and medical aspects of this multidisciplinary subject. Part of Series in Physics and Engineering in Medicine and Biology.

Enhanced oil recovery utilizing high-angle wells in the Frontier Formation, Badger Basin Field, Park County, Wyoming. Final report for the period October 1992--October 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, J.P.; Fortmann, R.G.

1994-12-01

Badger Basin Field, discovered in 1931, produces at stripper rates from low-permeability fractured sandstones of the Upper Cretaceous Frontier Formation. Only 15% of the estimated 25 million barrels of oil originally in-place will be produced from the twenty-two attempted vertical completions. This project will increase recoverable reserves through a better understanding of the reservoir and factors which control production. Characterization of the reservoir has been accomplished through an integrated engineering, geological and geophysical approach. Production data, drilling and completion techniques, and relative location of wells on the anticline were reviewed and related to productivity. Literature was reviewed for interpretations onmore » preferred flow directions on anticlinal structures. A structure map of the producing Frontier reservoir was constructed. Porosity development and its relationship to fracture networks was examined petrographically. Fractures in core were described and oriented using paleomagnetic techniques. Azimuths of fractures in outcrop were compared to fracture azimuths measured in the core. A 17 square-mile 3D seismic survey was designed, acquired and processed. Interpretation is being performed on a Sun workstation using Landmark Graphics software. Time-structure and amplitude-distribution maps will be constructed on three Frontier horizons. A location for a high-angle well will be chosen. The slant/horizontal test will be drilled and completed to increase recovery of reserves. Transfer of successful technologies will be accomplished by technical publications and presentations, and access to project materials, data, and field facilities.« less

Electronic and steric influences of pendant amine groups on the protonation of molybdenum bis (dinitrogen) complexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Labios, Liezel A.; Heiden, Zachariah M.; Mock, Michael T.

2015-05-04

The synthesis of a series of P EtP NRR' (P EtP NRR' = Et₂PCH₂CH₂P(CH₂NRR')₂, R = H, R' = Ph or 2,4-difluorophenyl; R = R' = Ph or iPr) diphosphine ligands containing mono- and disubstituted pendant amine groups, and the preparation of their corresponding molybdenum bis(dinitrogen) complexes trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') is described. In situ IR and multinuclear NMR spectroscopic studies monitoring the stepwise addition of (HOTf) to trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') complexes in THF at -40 °C show that the electronic and steric properties of the R and R' groups of the pendant amines influence whether the complexes are protonated atmore » Mo, a pendant amine, a coordinated N2 ligand, or a combination of these sites. For example, complexes containing mono-aryl substituted pendant amines are protonated at Mo and pendant amine to generate mono- and dicationic Mo–H species. Protonation of the complex containing less basic diphenyl-substituted pendant amines exclusively generates a monocationic hydrazido (Mo(NNH₂)) product, indicating preferential protonation of an N₂ ligand. Addition of HOTf to the complex featuring more basic diisopropyl amines primarily produces a monocationic product protonated at a pendant amine site, as well as a trace amount of dicationic Mo(NNH₂) product that contain protonated pendant amines. In addition, trans-Mo(N₂)₂(PMePh₂)₂(depe) (depe = Et₂PCH₂CH₂PEt₂) without a pendant amine was synthesized and treated with HOTf, generating a monocationic Mo(NNH₂) product. Protonolysis experiments conducted on select complexes in the series afforded trace amounts of NH₄⁺. Computational analysis of the series of trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') complexes provides further insight into the proton affinity values of the metal center, N₂ ligand, and pendant amine sites to rationalize the differing reactivity profiles. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Computational resources provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

CubeSat: Colorado Student Space Weather Experiment

NASA Astrophysics Data System (ADS)

Li, X.; Palo, S. E.; Turner, D. L.; Gerhardt, D.; Redick, T.; Tao, J.

2009-12-01

Energetic particles, electrons and protons either directly associated with solar flares or trapped in the terrestrial radiation belt, have a profound space weather impact. A 3U CubeSat mission with a single instrument, Relativistic Electrons and Proton Telescope integrated little experiment (REPTile), is proposed to address fundamental questions relating to the relationship between solar flares and energetic particles and the acceleration and loss mechanism of outer radiation belt electrons. REPTile, in a highly inclined low earth orbit, will measure differential fluxes of relativistic electrons in the energy range of 0.5-3.5 MeV and protons in 10-40 MeV. This project is a collaborative effort between the Laboratory for Atmospheric and Space Physics and the Department of Aerospace Engineering Sciences at the University of Colorado, which includes the integration of students, faculty, and professional engineers.

Gene and Cell Therapy for β-Thalassemia and Sickle Cell Disease with Induced Pluripotent Stem Cells (iPSCs): The Next Frontier.

PubMed

Papapetrou, Eirini P

2017-01-01

In recent years, breakthroughs in human pluripotent stem cell (hPSC) research, namely cellular reprogramming and the emergence of sophisticated genetic engineering technologies, have opened new frontiers for cell and gene therapy. The prospect of using hPSCs, either autologous or histocompatible, as targets of genetic modification and their differentiated progeny as cell products for transplantation, presents a new paradigm of regenerative medicine of potential tremendous value for the treatment of blood disorders, including beta-thalassemia (BT) and sickle cell disease (SCD). Despite advances at a remarkable pace and great promise, many roadblocks remain before clinical translation can be realistically considered. Here we discuss the theoretical advantages of cell therapies utilizing hPSC derivatives, recent proof-of-principle studies and the main challenges towards realizing the potential of hPSC therapies in the clinic.

Orbital Engineering: Photoactivation of an Organofunctionalized Polyoxotungstate.

PubMed

Cameron, Jamie M; Fujimoto, Satomi; Kastner, Katharina; Wei, Rong-Jia; Robinson, David; Sans, Victor; Newton, Graham N; Oshio, H Hiroki

2017-01-01

Tungsten-based polyoxometalates (POMs) have been employed as UV-driven photo-catalysts for a range of organic transformations. Their photoactivity is dependent on electronic transitions between frontier orbitals and thus manipulation of orbital energy levels provides a promising means of extending their utility into the visible regime. Herein, an organic-inorganic hybrid polyoxometalate, K 6 [P 2 W 17 O 57 (PO 5 H 5 C 7 ) 2 ]⋅6 C 4 H 9 NO, was found to exhibit enhanced redox behaviour and photochemistry compared to its purely inorganic counterparts. Hybridization with electron-withdrawing moieties was shown to tune the frontier orbital energy levels and reduce the HOMO-LUMO gap, leading to direct visible-light photoactivation of the hybrid and establishing a simple, cheap and effective approach to the generation of visible-light-activated hybrid nanomaterials. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Production and efficiency of large wildland fire suppression effort: A stochastic frontier analysis.

PubMed

Katuwal, Hari; Calkin, David E; Hand, Michael S

2016-01-15

This study examines the production and efficiency of wildland fire suppression effort. We estimate the effectiveness of suppression resource inputs to produce controlled fire lines that contain large wildland fires using stochastic frontier analysis. Determinants of inefficiency are identified and the effects of these determinants on the daily production of controlled fire line are examined. Results indicate that the use of bulldozers and fire engines increase the production of controlled fire line, while firefighter crews do not tend to contribute to controlled fire line production. Production of controlled fire line is more efficient if it occurs along natural or built breaks, such as rivers and roads, and within areas previously burned by wildfires. However, results also indicate that productivity and efficiency of the controlled fire line are sensitive to weather, landscape and fire characteristics. Copyright © 2015 Elsevier Ltd. All rights reserved.

Implication of substrate-assisted catalysis on improving lipase activity or enantioselectivity in organic solvents.

PubMed

Tsai, Shau-Wei; Chen, Chun-Chi; Yang, Hung-Shien; Ng, I-Son; Chen, Teh-Liang

2006-08-01

In comparison with the biocatalyst engineering and medium engineering approaches, very few examples have been reported on using the substrate engineering approach such as substrate-assisted catalysis (SAC) for naturally occurring or engineered lipases and serine proteases to improve the enzyme activity and enantioselectivity. By employing lipase-catalyzed hydrolysis of (R,S)-naproxen esters in water-saturated isooctane as the model system, we demonstrate the proton shuttle device to the leaving alcohol of the substrate as a new means of SAC to effectively improve the lipase activity or enantioselectivity. The result cannot only provide a strong evidence for the rate-limiting proton transfer for the bond-breaking of tetrahedron intermediate of the acylation step, but also sheds light for performing the hydrolysis, transesterification or aminolysis in organic solvents for the ester substrate that originally lipases cannot catalyze, but now can after introducing the device.

Progress on the accelerator based SPES-BNCT project at INFN Legnaro

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esposito, J.; Colautti, P.; Pisent, A.

2007-02-12

In the framework of an advanced Exotic Ion Beam facility, named SPES (Study and Production of Exotic Species), that will allow a frontier program both in nuclear and interdisciplinary physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma tumor, is currently under construction based on the SPES proton driver. A vast radiobiological investigation in vitro and in vivo has started with the new 10B carriers developed. Special microdosimetric detectors have been constructed to properly measure all the BNCT dose components and their qualities. Both microdosimetric and radiobiological measurements aremore » being performed at the new HYTHOR beam shaping assembly at the Enea-Casaccia TAPIRO reactor.« less

The future of the Large Hadron Collider and CERN.

PubMed

Heuer, Rolf-Dieter

2012-02-28

This paper presents the Large Hadron Collider (LHC) and its current scientific programme and outlines options for high-energy colliders at the energy frontier for the years to come. The immediate plans include the exploitation of the LHC at its design luminosity and energy, as well as upgrades to the LHC and its injectors. This may be followed by a linear electron-positron collider, based on the technology being developed by the Compact Linear Collider and the International Linear Collider collaborations, or by a high-energy electron-proton machine. This contribution describes the past, present and future directions, all of which have a unique value to add to experimental particle physics, and concludes by outlining key messages for the way forward.

Reviews Book: The 4% Universe: Dark Matter, Dark Energy and the Race to Discover the Rest of Reality Book: Quantitative Understanding of Biosystems: An Introduction to Biophysics Book: Edison's Electric Light: The Art of Invention Book: The Edge of Physics: Dispatches from the Frontiers of Cosmology Equipment: Voicebox Equipment: Tracker 4 Books: Hands-On Introduction to NI LabVIEW with Vernier, and Engineering Projects with NI LabVIEW and Vernier Places to Visit: Discovery Museum Book: Philosophy of Science: A Very Short Introduction Web Watch

NASA Astrophysics Data System (ADS)

2011-11-01

WE RECOMMEND Quantitative Understanding of Biosystems: An Introduction to Biophysics Text applies physics to biology concepts Edison's Electric Light: The Art of Invention Edison's light still shines brightly The Edge of Physics: Dispatches from the Frontiers of Cosmology Anecdotes explore cosmology Voicebox Voicebox kit discovers the physics and evolution of speech Tracker 4 Free software tracks motion analysis Hands-On Introduction to NI LabVIEW with Vernier, and Engineering Projects with NI LabVIEW and Vernier Books support the LabVIEW software Discovery Museum Newcastle museum offers science enjoyment for all Philosophy of Science: A Very Short Introduction Philosophy opens up science questions WORTH A LOOK The 4% Universe: Dark Matter, Dark Energy and the Race to Discover the Rest of Reality Book researches the universe WEB WATCH Superconductivity websites are popular

Box 11: Tissue Engineering and Bioscience Methods Using Proton Beam Writing

NASA Astrophysics Data System (ADS)

van Kan, J. A.

Tissue engineering is a rapidly developing and highly interdisciplinary field that applies the principles of cell biology, engineering, and materials science to the culture of biological tissue. The artificially grown tissue then can be implanted directly into the body, or it can form part of a device that replaces organ functionality.

Study of an advanced General Aviation Turbine Engine (GATE)

NASA Technical Reports Server (NTRS)

Gill, J. C.; Short, F. R.; Staton, D. V.; Zolezzi, B. A.; Curry, C. E.; Orelup, M. J.; Vaught, J. M.; Humphrey, J. M.

1979-01-01

The best technology program for a small, economically viable gas turbine engine applicable to the general aviation helicopter and aircraft market for 1985-1990 was studied. Turboshaft and turboprop engines in the 112 to 746 kW (150 to 1000 hp) range and turbofan engines up to 6672 N (1500 lbf) thrust were considered. A good market for new turbine engines was predicted for 1988 providing aircraft are designed to capitalize on the advantages of the turbine engine. Parametric engine families were defined in terms of design and off-design performance, mass, and cost. These were evaluated in aircraft design missions selected to represent important market segments for fixed and rotary-wing applications. Payoff parameters influenced by engine cycle and configuration changes were aircraft gross mass, acquisition cost, total cost of ownership, and cash flow. Significant advantage over a current technology, small gas turbine engines was found especially in cost of ownership and fuel economy for airframes incorporating an air-cooled high-pressure ratio engine. A power class of 373 kW (500 hp) was recommended as the next frontier for technology advance where large improvements in fuel economy and engine mass appear possible through component research and development.

Chromatin regulation at the frontier of synthetic biology.

PubMed

Keung, Albert J; Joung, J Keith; Khalil, Ahmad S; Collins, James J

2015-03-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including 'epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication.

Chromatin regulation at the frontier of synthetic biology

PubMed Central

Keung, Albert J.; Joung, J. Keith; Khalil, Ahmad S.; Collins, James J.

2016-01-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including `epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. PMID:25668787

Simulations and measurements of beam loss patterns at the CERN Large Hadron Collider

NASA Astrophysics Data System (ADS)

Bruce, R.; Assmann, R. W.; Boccone, V.; Bracco, C.; Brugger, M.; Cauchi, M.; Cerutti, F.; Deboy, D.; Ferrari, A.; Lari, L.; Marsili, A.; Mereghetti, A.; Mirarchi, D.; Quaranta, E.; Redaelli, S.; Robert-Demolaize, G.; Rossi, A.; Salvachua, B.; Skordis, E.; Tambasco, C.; Valentino, G.; Weiler, T.; Vlachoudis, V.; Wollmann, D.

2014-08-01

The CERN Large Hadron Collider (LHC) is designed to collide proton beams of unprecedented energy, in order to extend the frontiers of high-energy particle physics. During the first very successful running period in 2010-2013, the LHC was routinely storing protons at 3.5-4 TeV with a total beam energy of up to 146 MJ, and even higher stored energies are foreseen in the future. This puts extraordinary demands on the control of beam losses. An uncontrolled loss of even a tiny fraction of the beam could cause a superconducting magnet to undergo a transition into a normal-conducting state, or in the worst case cause material damage. Hence a multistage collimation system has been installed in order to safely intercept high-amplitude beam protons before they are lost elsewhere. To guarantee adequate protection from the collimators, a detailed theoretical understanding is needed. This article presents results of numerical simulations of the distribution of beam losses around the LHC that have leaked out of the collimation system. The studies include tracking of protons through the fields of more than 5000 magnets in the 27 km LHC ring over hundreds of revolutions, and Monte Carlo simulations of particle-matter interactions both in collimators and machine elements being hit by escaping particles. The simulation results agree typically within a factor 2 with measurements of beam loss distributions from the previous LHC run. Considering the complex simulation, which must account for a very large number of unknown imperfections, and in view of the total losses around the ring spanning over 7 orders of magnitude, we consider this an excellent agreement. Our results give confidence in the simulation tools, which are used also for the design of future accelerators.

Conjecture regarding posttranslational modifications to the arabidopsis type I proton-pumping pyrophosphatase (AVP1)

USDA-ARS?s Scientific Manuscript database

Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational resear...

Survey on the use of smart and adaptive engineering systems in medicine.

PubMed

Abbod, M F; Linkens, D A; Mahfouf, M; Dounias, G

2002-11-01

In this paper, the current published knowledge about smart and adaptive engineering systems in medicine is reviewed. The achievements of frontier research in this particular field within medical engineering are described. A multi-disciplinary approach to the applications of adaptive systems is observed from the literature surveyed. The three modalities of diagnosis, imaging and therapy are considered to be an appropriate classification method for the analysis of smart systems being applied to specified medical sub-disciplines. It is expected that future research in biomedicine should identify subject areas where more advanced intelligent systems could be applied than is currently evident. The literature provides evidence of hybridisation of different types of adaptive and smart systems with applications in different areas of medical specifications. Copyright 2002 Elsevier Science B.V.

Fundamental physics at the intensity frontier. Report of the workshop held December 2011 in Rockville, MD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hewett, J.L.; Weerts, H.; Brock, R.

2012-06-05

Particle physics aims to understand the universe around us. The Standard Model of particle physics describes the basic structure of matter and forces, to the extent we have been able to probe thus far. However, it leaves some big questions unanswered. Some are within the Standard Model itself, such as why there are so many fundamental particles and why they have different masses. In other cases, the Standard Model simply fails to explain some phenomena, such as the observed matter-antimatter asymmetry in the universe, the existence of dark matter and dark energy, and the mechanism that reconciles gravity with quantummore » mechanics. These gaps lead us to conclude that the universe must contain new and unexplored elements of Nature. Most of particle and nuclear physics is directed towards discovering and understanding these new laws of physics. These questions are best pursued with a variety of approaches, rather than with a single experiment or technique. Particle physics uses three basic approaches, often characterized as exploration along the cosmic, energy, and intensity frontiers. Each employs different tools and techniques, but they ultimately address the same fundamental questions. This allows a multi-pronged approach where attacking basic questions from different angles furthers knowledge and provides deeper answers, so that the whole is more than a sum of the parts. A coherent picture or underlying theoretical model can more easily emerge, to be proven correct or not. The intensity frontier explores fundamental physics with intense sources and ultra-sensitive, sometimes massive detectors. It encompasses searches for extremely rare processes and for tiny deviations from Standard Model expectations. Intensity frontier experiments use precision measurements to probe quantum effects. They typically investigate very large energy scales, even higher than the kinematic reach of high energy particle accelerators. The science addresses basic questions, such as: Are there new sources of CP violation? Is there CP violation in the leptonic sector? Are neutrinos their own antiparticles? Do the forces unify? Is there a weakly coupled hidden sector that is related to dark matter? Do new symmetries exist at very high energy scales? To identify the most compelling science opportunities in this area, the workshop Fundamental Physics at the Intensity Frontier was held in December 2011, sponsored by the Office of High Energy Physics in the US Department of Energy Office of Science. Participants investigated the most promising experiments to exploit these opportunities and described the knowledge that can be gained from such a program. The workshop generated much interest in the community, as witnessed by the large and energetic participation by a broad spectrum of scientists. This document chronicles the activities of the workshop, with contributions by more than 450 authors. The workshop organized the intensity frontier science program along six topics that formed the basis for working groups: experiments that probe (i) heavy quarks, (ii) charged leptons, (iii) neutrinos, (iv) proton decay, (v) light, weakly interacting particles, and (vi) nucleons, nuclei, and atoms. The conveners for each working group included an experimenter and a theorist working in the field and an observer from the community at large. The working groups began their efforts well in advance of the workshop, holding regular meetings and soliciting written contributions. Specific avenues of exploration were identified by each working group. Experiments that study rare strange, charm, and bottom meson decays provide a broad program of measurements that are sensitive to new interactions. Charged leptons, particularly muons and taus, provide a precise probe for new physics because the Standard Model predictions for their properties are very accurate. Research at the intensity frontier can reveal CP violation in the lepton sector, and elucidate whether neutrinos are their own antiparticles. A very weakly coupled hidden-sector that may comprise the dark matter in the universe could be discovered. The search for proton decay can probe the unification of the forces with unprecedented reach and test sacrosanct symmetries to very high scales. Detecting an electric dipole moment for the neutron, or neutral atoms, could establish a clear signal for new physics, while limits on such a measurement would place severe constraints on many new theories. This workshop marked the first instance where discussion of these diverse programs was held under one roof. As a result, it was realized that this broad effort has many connections; a large degree of synergy exists between the different areas and they address similar questions. Results from one area were found to be pertinent to experiments in another domain.« less

Singlet-catalyzed electroweak phase transitions in the 100 TeV frontier

DOE PAGES

Kotwal, Ashutosh V.; Ramsey-Musolf, Michael J.; No, Jose Miguel; ...

2016-08-23

We study the prospects for probing a gauge singlet scalar-driven strong first-order electroweak phase transition with a future proton-proton collider in the 100 TeV range. Singlet-Higgs mixing enables resonantly enhanced di-Higgs production, potentially aiding discovery prospects. We perform Monte Carlo scans of the parameter space to identify regions associated with a strong first-order electroweak phase transition, analyze the corresponding di-Higgs signal, and select a set of benchmark points that span the range of di-Higgs signal strengths. For the bmore » $$\\bar{b}$$γγ and 4τ final states, we investigate discovery prospects for each benchmark point for the high-luminosity phase of the Large Hadron Collider and for a future pp collider with s=50, 100, or 200 TeV. We find that any of these future collider scenarios could significantly extend the reach beyond that of the high-luminosity LHC, and that with s=100 TeV (200 TeV) and 30 ab -1, the full region of parameter space favorable to strong first-order electroweak phase transitions is almost fully (fully) discoverable.« less

Ultra-peripheral collisions and hadronic structure

NASA Astrophysics Data System (ADS)

Klein, Spencer R.

2017-11-01

Ultra-peripheral collisions are the energy frontier for photon-mediated interactions, reaching, at the Large Hadron Collider (LHC), γ - p center of mass energies five to ten times higher than at HERA and reaching γγ energies higher than at LEP. Photoproduction of heavy quarkonium and dijets in pp and pA collisions probes the gluon distribution in protons at Bjorken-x values down to 3 ×10-6, far smaller than can be otherwise studied. In AA collisions, these reactions probe the gluon distributions in heavy ions, down to x values of a few 10-5. Although more theoretical work is needed to nail down all of the uncertainties, inclusion of these data in current parton distribution function fits would greatly improve the accuracy of the gluon distributions at low Bjorken-x and low/moderate Q2. High-statistics ρ0 data probe the spatial distribution of the interaction sites; the site distribution is given by the Fourier transform of dσ / dt. After introducing UPCs, this review presents recent measurements of dilepton production and light-by-light scattering and recent data on proton and heavy nuclei structure, emphasizing results presented at Quark Matter 2017 (QM2017).

Heavy Ion Acceleration at J-PARC

NASA Astrophysics Data System (ADS)

SATO, Susumu

2018-02-01

J-PARC, the Japan Proton Accelerator Research Complex, is an accelerator, which provides a high-intensity proton beam. Recently as a very attractive project, the acceleration of heavy ions produced by supplementary ion sources, called J-PARC-HI, is seriously contemplated by domestic as well as international communities. The planned facility would accelerate heavy ions up to U92+ with a beam energy 20 AGeV ( of 6.2 AGeV). The highlight of the J-PARC-HI project is its very high beam rate up to 1011 Hz, which will enable the study of very rare events. Taking advantage of this high intensity, J-PARC-HI will carry out frontier studies of new and rare observables in this energy region: (i) nuclear medium modification of chiral property of vector mesons through low-mass di-lepton signal, (ii) QCD critical pointcharacterization through event-by-event fluctuation signals of particle production, (iii) systematic measurements related to the equation of state through collective flow signal or two-particle momentum correlation signal, or (iv) the search of hyper nuclei with multi strangeness including or exceeding S = 3. The current plan of J-PARC-HI aims to carrying out the first experimental measurements in 2025.

Effect of protonation of the N-acetyl neuraminic acid residue of sialyl Lewis(X): a molecular orbital study with insights into its binding properties toward the carbohydrate recognition domain of E-selectin.

PubMed

Pichierri, Fabio; Matsuo, Yo

2002-08-01

Semiempirical molecular orbital (MO) calculations with an implicit treatment of the water environment were employed in order to assess whether the sialyl Lewis(X) (sLe(X)) tetrasaccharide binds to E-selectin in the anionic or neutral (i.e., protonated) state. The analysis of the frontier molecular orbitals, electrostatic potential surfaces, and conformational behavior of the sugar indicates that its neutral form possesses the necessary characteristics for binding. In particular, the LUMO level of the neutral sLe(X) molecule is localized both on the carboxylic group of the N-acetyl neuraminic acid (NeuNAc) residue and on the nearby glycosidic linkage. These two moieties interact with the Arg97 residue of E-selectin, as revealed by a recent crystal structure analysis of the E-selectin/sLe(X) complex. The energetics of this specific interaction was investigated with the aid of ab initio Hartree-Fock MO calculations, which resulted in a BSSE-corrected binding energy of 16.63 kcal/mol. Our observations could open up new perspectives in the design of sLe(X) mimics.

High and Mighty: Implicit Associations between Space and Social Status

DTIC Science & Technology

2011-10-10

WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Natick Soldier Research, Development , and Engineering Center,15 Kansas... developed using six differently styled grayscale compass roses; half of these 12 images depicted the letter N in the center (north), and half the letter S ...Divide: Historical Archae- ologies of Race, Class, and Gender, eds. J. A. Delle, S . A. Mrozowski, and Frontiers in Psychology | Cognition October 2011

Applying Systems Engineering Methodologies to the Creative Process

DTIC Science & Technology

2014-09-01

Carrasco, and Ranee A. Flores. 2013. “The Structure of Creative Cognition in the Human Brain .” Frontiers in Human Neuroscience 7: 1–13. doi: 10.3389/fnhum...The place aspect of creativity will be addressed in a limited fashion to raise awareness of possible prescriptive methods to enhance creativity...threshold theory states, “…creativity and intelligence are correlated up to a certain threshold [around an intelligence quotient ( IQ ) of 120] after which

Characterization of Gas-Phase Organics Using Proton Transfer Reaction Time-of-Flight Mass Spectrometry: Aircraft Turbine Engines.

PubMed

Kilic, Dogushan; Brem, Benjamin T; Klein, Felix; El-Haddad, Imad; Durdina, Lukas; Rindlisbacher, Theo; Setyan, Ari; Huang, Rujin; Wang, Jing; Slowik, Jay G; Baltensperger, Urs; Prevot, Andre S H

2017-04-04

Nonmethane organic gas emissions (NMOGs) from in-service aircraft turbine engines were investigated using a proton transfer reaction time-of-flight mass spectrometer (PTR-ToF-MS) at an engine test facility at Zurich Airport, Switzerland. Experiments consisted of 60 exhaust samples for seven engine types (used in commercial aviation) from two manufacturers at thrust levels ranging from idle to takeoff. Emission indices (EIs) for more than 200 NMOGs were quantified, and the functional group fractions (including acids, carbonyls, aromatics, and aliphatics) were calculated to characterize the exhaust chemical composition at different engine operation modes. Total NMOG emissions were highest at idling with an average EI of 7.8 g/kg fuel and were a factor of ∼40 lower at takeoff thrust. The relative contribution of pure hydrocarbons (particularly aromatics and aliphatics) of the engine exhaust decreased with increasing thrust while the fraction of oxidized compounds, for example, acids and carbonyls increased. Exhaust chemical composition at idle was also affected by engine technology. Older engines emitted a higher fraction of nonoxidized NMOGs compared to newer ones. Idling conditions dominated ground level organic gas emissions. Based on the EI determined here, we estimate that reducing idle emissions could substantially improve air quality near airports.

Subunit III-depleted cytochrome c oxidase provides insight into the process of proton uptake by proteins

PubMed Central

Varanasi, Lakshman; Hosler, Jonathan P.

2011-01-01

We review studies of subunit III-depleted cytochrome c oxidase (CcO III (−)) that elucidate the structural basis of steady-state proton uptake from solvent into an internal proton transfer pathway. The removal of subunit III from R. sphaeroides CcO makes proton uptake into the D pathway a rate-determining step, such that measurements of the pH dependence of steady-state O2 consumption can be used to compare the rate and functional pKa of proton uptake by D pathways containing different initial proton acceptors. The removal of subunit III also promotes spontaneous suicide inactivation by CcO, greatly shortening its catalytic lifespan. Because the probability of suicide inactivation is controlled by the rate at which the D pathway delivers protons to the active site, measurements of catalytic lifespan provide a second method to compare the relative efficacy of proton uptake by engineered CcO III (−) forms. These simple experimental systems have been used to explore general questions of proton uptake by proteins, such as the functional value of an initial proton acceptor, whether an initial acceptor must be surface-exposed, which side chains will function as initial proton acceptors and whether multiple acceptors can speed proton uptake. PMID:22023935

Thermally triggered polyrotaxane translational motion helps proton transfer.

PubMed

Ge, Xiaolin; He, Yubin; Liang, Xian; Wu, Liang; Zhu, Yuan; Yang, Zhengjin; Hu, Min; Xu, Tongwen

2018-06-12

Synthetic polyelectrolytes, capable of fast transporting protons, represent a challenging target for membrane engineering in so many fields, for example, fuel cells, redox flow batteries, etc. Inspired by the fast advance in molecular machines, here we report a rotaxane based polymer entity assembled via host-guest interaction and prove that by exploiting the thermally triggered translational motion (although not in a controlled manner) of mechanically bonded rotaxane, exceptionally fast proton transfer can be fulfilled at an external thermal input. The relative motion of the sulfonated axle to the ring in rotaxane happens at ~60 °C in our cases and because of that a proton conductivity (indicating proton transfer rate) of 260.2 mS cm -1 , which is much higher than that in the state-of-the-art Nafion, is obtained at a relatively low ion-exchange capacity (representing the amount of proton transfer groups) of 0.73 mmol g -1 .

New superconducting cyclotron driven scanning proton therapy systems

NASA Astrophysics Data System (ADS)

Klein, Hans-Udo; Baumgarten, Christian; Geisler, Andreas; Heese, Jürgen; Hobl, Achim; Krischel, Detlef; Schillo, Michael; Schmidt, Stefan; Timmer, Jan

2005-12-01

Since one and a half decades ACCEL is investing in development and engineering of state of the art particle-therapy systems. A new medical superconducting 250 MeV proton cyclotron with special focus on the present and future beam requirements of fast scanning treatment systems has been designed. The first new ACCEL medical proton cyclotron is under commissioning at PSI for their PROSCAN proton therapy facility having undergone successful factory tests especially of the closed loop cryomagnetic system. The second cyclotron is part of ACCEL's integrated proton therapy system for Europe's first clinical center, RPTC in Munich. The cyclotron, the energy selection system, the beamline as well as the four gantries and patient positioners have been installed. The scanning system and major parts of the control software have already been tested. We will report on the concept of ACCEL's superconducting cyclotron driven scanning proton therapy systems and the current status of the commissioning work at PSI and RPTC.

Exploring New Physics Beyond the Standard Model: Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Liantao

This grant in 2015 to 2016 was for support in the area of theoretical High Energy Physics. The research supported focused mainly on the energy frontier, but it also has connections to both the cosmic and intensity frontiers. Lian-Tao Wang (PI) focused mainly on signal of new physics at colliders. The year 2015 - 2016, covered by this grant, has been an exciting period of digesting the influx of LHC data, understanding its meaning, and using it to refine strategies for deeper exploration. The PI proposed new methods of searching for new physics at the LHC, such as for themore » compressed stops. He also investigated in detail the signal of composite Higgs models, focusing on spin-1 composite resonances in the di-boson channel. He has also considered di-photon as a probe for such models. He has also made contributions in formulating search strategies of dark matter at the LHC, resulting in two documents with recommendations. The PI has also been active in studying the physics potential of future colliders, including Higgs factories and 100 TeV pp colliders. He has given comprehensive overview of the physics potential of the high energy proton collider, and outline its luminosity targets. He has also studied the use of lepton colliders to probe fermionic Higgs portal and bottom quark couplings to the Z boson.« less

Covalent Organic Frameworks as a Platform for Multidimensional Polymerization.

PubMed

Bisbey, Ryan P; Dichtel, William R

2017-06-28

The simultaneous polymerization and crystallization of monomers featuring directional bonding designs provides covalent organic frameworks (COFs), which are periodic polymer networks with robust covalent bonds arranged in two- or three-dimensional topologies. The range of properties characterized in COFs has rapidly expanded to include those of interest for heterogeneous catalysis, energy storage and photovoltaic devices, and proton-conducting membranes. Yet many of these applications will require materials quality, morphological control, and synthetic efficiency exceeding the capabilities of contemporary synthetic methods. This level of control will emerge from an improved fundamental understanding of COF nucleation and growth processes. More powerful characterization of structure and defects, improved syntheses guided by mechanistic understanding, and accessing diverse isolated forms, ranging from single crystals to thin films to colloidal suspensions, remain important frontier problems.

Covalent Organic Frameworks as a Platform for Multidimensional Polymerization

PubMed Central

2017-01-01

The simultaneous polymerization and crystallization of monomers featuring directional bonding designs provides covalent organic frameworks (COFs), which are periodic polymer networks with robust covalent bonds arranged in two- or three-dimensional topologies. The range of properties characterized in COFs has rapidly expanded to include those of interest for heterogeneous catalysis, energy storage and photovoltaic devices, and proton-conducting membranes. Yet many of these applications will require materials quality, morphological control, and synthetic efficiency exceeding the capabilities of contemporary synthetic methods. This level of control will emerge from an improved fundamental understanding of COF nucleation and growth processes. More powerful characterization of structure and defects, improved syntheses guided by mechanistic understanding, and accessing diverse isolated forms, ranging from single crystals to thin films to colloidal suspensions, remain important frontier problems. PMID:28691064

Enhanced Proton Conductivity in Y-Doped BaZrO3 via Strain Engineering.

PubMed

Fluri, Aline; Marcolongo, Aris; Roddatis, Vladimir; Wokaun, Alexander; Pergolesi, Daniele; Marzari, Nicola; Lippert, Thomas

2017-12-01

The effects of stress-induced lattice distortions (strain) on the conductivity of Y-doped BaZrO 3 , a high-temperature proton conductor with key technological applications for sustainable electrochemical energy conversion, are studied. Highly ordered epitaxial thin films are grown in different strain states while monitoring the stress generation and evolution in situ. Enhanced proton conductivity due to lower activation energies is discovered under controlled conditions of tensile strain. In particular, a twofold increased conductivity is measured at 200 °C along a 0.7% tensile strained lattice. This is at variance with conclusions coming from force-field simulations or the static calculations of diffusion barriers. Here, extensive first-principles molecular dynamic simulations of proton diffusivity in the proton-trapping regime are therefore performed and found to agree with the experiments. The simulations highlight that compressive strain confines protons in planes parallel to the substrate, while tensile strain boosts diffusivity in the perpendicular direction, with the net result that the overall conductivity is enhanced. It is indeed the presence of the dopant and the proton-trapping effect that makes tensile strain favorable for proton conduction.

Historic Frontier Processes active in Future Space-Based Mineral Extraction

NASA Astrophysics Data System (ADS)

Gray, D. M.

2000-01-01

The forces that shaped historic mining frontiers are in many cases not bound by geographic or temporal limits. The forces that helped define historic frontiers are active in today's physical and virtual frontiers, and will be present in future space-based frontiers. While frontiers derived from position and technology are primarily economic in nature, non-economic conditions affect the success or failure of individual frontier endeavors, local "mining camps" and even entire frontiers. Frontiers can be defined as the line of activity that divides the established markets and infrastructure of civilization from the unclaimed resources and potential wealth of a wilderness. At the frontier line, ownership of resources is established. The resource can then be developed using capital, energy and information. In a mining setting, the resource is concentrated for economic shipment to the markets of civilization. Profits from the sale of the resource are then used to fund further development of the resource and/or pay investors. Both positional and technical frontiers develop as a series of generations. The profits from each generation of development provides the capital and/or investment incentive for the next round of development. Without profit, the self-replicating process of frontiers stops.

Ozone depletion caused by NO and H2O emissions from hydrazine-fueled rockets

NASA Astrophysics Data System (ADS)

Ross, M. N.; Danilin, M. Y.; Weisenstein, D. K.; Ko, M. K. W.

2004-11-01

Rockets using unsymmetrical dimethyl hydrazine (N(CH3)2NH2) and dinitrogen tetroxide (N2O4) propellants account for about one third of all stratospheric rocket engine emissions, comparable to the solid-fueled rocket emissions. We use plume and global atmosphere models to provide the first estimate of the local and global ozone depletion caused by NO and H2O emissions from the Proton rocket, the largest hydrazine-fueled launcher in use. NO and H2O emission indices are assumed to be 20 and 350 g/kg (propellant), respectively. Predicted maximum ozone loss in the plume of the Proton rocket is 21% at 44 km altitude. Plume ozone loss at 20 km equals 8% just after launch and steadily declines to 2% by model sunset. Predicted steady state global ozone loss from ten Proton launches annually is 1.2 × 10-4%, with nearly all of the loss due to the NO component of the emission. Normalized by stratospheric propellant consumption, the global ozone depletion efficiency of the Proton is approximately 66-90 times less than that of solid-fueled rockets. In situ Proton plume measurements are required to validate assumed emission indices and to assess the role of rocket emissions not considered in these calculations. Such future studies would help to establish a formalism to evaluate the relative ozone depletion caused by different rocket engines using different propellants.

Biological Physics major as a means to stimulate an undergraduate physics program

NASA Astrophysics Data System (ADS)

Jaeger, Herbert; Eid, Khalid; Yarrison-Rice, Jan

2013-03-01

In an effort to stress the cross-disciplinary nature of modern physics we added a Biological Physics major. Drawing from coursework in physics, biology, chemistry, mathematics, and related disciplines, it combines a broad curriculum with physical and mathematical rigor in preparation for careers in biophysics, medical physics, and biomedical engineering. Biological Physics offers a new path of studies to a large pool of life science students. We hope to grow our physics majors from 70-80 to more than 100 students and boost our graduation rate from the mid-teens to the mid-twenties. The new major brought about a revision of our sophomore curriculum to make room for modern topics without sidelining fundamentals. As a result, we split our 1-semester long Contemporary Physics course (4 cr hrs) into a year-long sequence Contemporary Physics Foundations and Contemporary Physics Frontiers (both 3 cr hrs). Foundations starts with relativity, then focuses on 4 quantum mechanics topics: wells, spin 1/2, oscillators, and hydrogen. Throughout the course applications are woven in whenever the opportunity arises, e.g. magnetism and NMR with spin 1/2. The following semester Frontiers explores scientific principles and technological advances that make quantum science and resulting technologies different from the large scale. Frontiers covers enabling techniques from atomic, molecular, condensed matter, and particle physics, as well as advances in nanotechnology, quantum optics, and biophysics.

The Herschel Lensing Survey (HLS): HST Frontier Field Coverage

NASA Astrophysics Data System (ADS)

Egami, Eiichi

2015-08-01

The Herschel Lensing Survey (HLS; PI: Egami) is a large Far-IR/Submm imaging survey of massive galaxy clusters using the Herschel Space Observatory. Its main goal is to detect and study IR/Submm galaxies that are below the nominal confusion limit of Herschel by taking advantage of the strong gravitational lensing power of massive galaxy clusters. HLS has obtained deep PACS (100/160 um) and SPIRE (250/350/500 um) images for 54 cluster fields (HLS-deep) as well as shallower but nearly confusion-limited SPIRE-only images for 527 cluster fields (HLS-snapshot) with a total observing time of ~420 hours. Extensive multi-wavelength follow-up studies are currently on-going with a variety of observing facilities including ALMA.Here, I will focus on the analysis of the deep Herschel PACS/SPIRE images obtained for the 6 HST Frontier Fields (5 observed by HLS-deep; 1 observed by the Herschel GT programs). The Herschel/SPIRE maps are wide enough to cover the Frontier-Field parallel pointings, and we have detected a total of ~180 sources, some of which are strongly lensed. I will present the sample and discuss the properties of these Herschel-detected dusty star-forming galaxies (DSFGs) identified in the Frontier Fields. Although the majority of these Herschel sources are at moderate redshift (z<3), a small number of extremely high-redshift (z>6) candidates can be identified as "Herschel dropouts" when combined with longer-wavelength data. We have also identified ~40 sources as likely cluster members, which will allow us to study the properties of DSFGs in the dense cluster environment.A great legacy of our HLS project will be the extensive multi-wavelength database that incorporates most of the currently available data/information for the fields of the Frontier-Field, CLASH, and other HLS clusters (e.g., HST/Spitzer/Herschel images, spectroscopic/photometric redshifts, lensing models, best-fit SED models etc.). Provided with a user-friendly GUI and a flexible search engine, this database should serve as a powerful tool for a variety of projects including those with ALMA and JWST in the future. I will conclude by introducing this HLS database system.

Proposal for an Accelerator R&D User Facility at Fermilab's Advanced Superconducting Test Accelerator (ASTA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Church, M.; Edwards, H.; Harms, E.

2013-10-01

Fermilab is the nation’s particle physics laboratory, supported by the DOE Office of High Energy Physics (OHEP). Fermilab is a world leader in accelerators, with a demonstrated track-record— spanning four decades—of excellence in accelerator science and technology. We describe the significant opportunity to complete, in a highly leveraged manner, a unique accelerator research facility that supports the broad strategic goals in accelerator science and technology within the OHEP. While the US accelerator-based HEP program is oriented toward the Intensity Frontier, which requires modern superconducting linear accelerators and advanced highintensity storage rings, there are no accelerator test facilities that support themore » accelerator science of the Intensity Frontier. Further, nearly all proposed future accelerators for Discovery Science will rely on superconducting radiofrequency (SRF) acceleration, yet there are no dedicated test facilities to study SRF capabilities for beam acceleration and manipulation in prototypic conditions. Finally, there are a wide range of experiments and research programs beyond particle physics that require the unique beam parameters that will only be available at Fermilab’s Advanced Superconducting Test Accelerator (ASTA). To address these needs we submit this proposal for an Accelerator R&D User Facility at ASTA. The ASTA program is based on the capability provided by an SRF linac (which provides electron beams from 50 MeV to nearly 1 GeV) and a small storage ring (with the ability to store either electrons or protons) to enable a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop transformative approaches to particle-beam generation, acceleration and manipulation which cannot be done elsewhere. It will also establish a unique resource for R&D towards Energy Frontier facilities and a test-bed for SRF accelerators and high brightness beam applications in support of the OHEP mission of Accelerator Stewardship.« less

Frontiers in Chemical Sensors: Novel Principles and Techniques

NASA Astrophysics Data System (ADS)

Orellana, Guillermo; Moreno-Bondi, Maria Cruz

This third volume of Springer Series on Chemical Sensors and Biosensors aims to enable the researcher or technologist to become acquainted with the latest principles and techniques that keep on enlarging the applications in this fascinating field. It deals with the novel luminescence lifetime-based techniques for interrogation of sensor arrays in high-throughput screening, cataluminescence, chemical sensing with hollow waveguides, new ways in sensor design and fabrication by means of either combinatorial methods or engineered indicator/support couples.

East African ROAD

NASA Astrophysics Data System (ADS)

Tekle, Kelali

2016-10-01

In the developing world astronomy had been treated as the science of elites. As a result of this overwhelming perception, astronomy compared with other applied sciences has got less attention and its role in development has been insignificant. However, the IAU General Assembly decision in 2009 opened new opportunity for countries and professionals to deeply look into Astronomy and its role in development. Then, the subsequent establishment of regional offices in the developing world is helping countries to integrate astronomy with other earth and space based sciences so as to progressively promote its scientific and development importance. Gradually nations have come to know that space is the frontier of tomorrow and the urgency of preeminence on space frontier starts at primary school and ascends to tertiary education. For this to happen, member nations in east African region have placed STEM education at the center of their education system. For instance, Ethiopian has changed University enrollment strategy to be in favor of science and engineering subjects, i.e. every year seventy percent of new University entrants join science and engineering fields while thirty percent social science and humanities. Such bold actions truly promote astronomy to be conceived as gateway to science and technology. To promote the concept of astronomy for development the East African regional office has actually aligned it activities to be in line with the focus areas identified by the IAU strategy (2010 to 2020).

Energy: the microfluidic frontier.

PubMed

Sinton, David

2014-09-07

Global energy is largely a fluids problem. It is also large-scale, in stark contrast to microchannels. Microfluidic energy technologies must offer either massive scalability or direct relevance to energy processes already operating at scale. We have to pick our fights. Highlighted here are the exceptional opportunities I see, including some recent successes and areas where much more attention is needed. The most promising directions are those that leverage high surface-to-volume ratios, rapid diffusive transport, capacity for high temperature and high pressure experiments, and length scales characteristic of microbes and fluids (hydrocarbons, CO2) underground. The most immediate areas of application are where information is the product; either fluid sample analysis (e.g. oil analysis); or informing operations (e.g. CO2 transport in microporous media). I'll close with aspects that differentiate energy from traditional microfluidics applications, the uniquely important role of engineering in energy, and some thoughts for the research community forming at the nexus of lab-on-a-chip and energy--a microfluidic frontier.

Irksome and Unpopular Duties: Pakistan’s Frontier Corps, Local Security Forces and Counterinsurgency

DTIC Science & Technology

2012-05-01

the Karakorum mountain range in North West Frontier Province (now Khyber Pakhtunkhwa) to the Makran coast in Balochistan . I he Khan <>l Lalpura and...the corps along geographical lines, creating Frontier Corps-North West Frontier Province and Frontier Corps- Balochistan . Pakistan also created...major combat operations, including the Indo-Pakistani wars of 1948, 1965, and 1971. The Frontier Corps fought against separatists in Balochistan in the

A Centaur Reconnaissance Mission: a NASA JPL Planetary Science Summer Seminar mission design experience

NASA Astrophysics Data System (ADS)

Chou, L.; Howell, S. M.; Bhattaru, S.; Blalock, J. J.; Bouchard, M.; Brueshaber, S.; Cusson, S.; Eggl, S.; Jawin, E.; Marcus, M.; Miller, K.; Rizzo, M.; Smith, H. B.; Steakley, K.; Thomas, N. H.; Thompson, M.; Trent, K.; Ugelow, M.; Budney, C. J.; Mitchell, K. L.

2017-12-01

The NASA Planetary Science Summer Seminar (PSSS), sponsored by the Jet Propulsion Laboratory (JPL), offers advanced graduate students and recent doctoral graduates the unique opportunity to develop a robotic planetary exploration mission that answers NASA's Science Mission Directorate's Announcement of Opportunity for the New Frontiers Program. Preceded by a series of 10 weekly webinars, the seminar is an intensive one-week exercise at JPL, where students work directly with JPL's project design team "TeamX" on the process behind developing mission concepts through concurrent engineering, project design sessions, instrument selection, science traceability matrix development, and risks and cost management. The 2017 NASA PSSS team included 18 participants from various U.S. institutions with a diverse background in science and engineering. We proposed a Centaur Reconnaissance Mission, named CAMILLA, designed to investigate the geologic state, surface evolution, composition, and ring systems through a flyby and impact of Chariklo. Centaurs are defined as minor planets with semi-major axis that lies between Jupiter and Neptune's orbit. Chariklo is both the largest Centaur and the only known minor planet with rings. CAMILLA was designed to address high priority cross-cutting themes defined in National Research Council's Vision and Voyages for Planetary Science in the Decade 2013-2022. At the end of the seminar, a final presentation was given by the participants to a review board of JPL scientists and engineers as well as NASA headquarters executives. The feedback received on the strengths and weaknesses of our proposal provided a rich and valuable learning experience in how to design a successful NASA planetary exploration mission and generate a successful New Frontiers proposal. The NASA PSSS is an educational experience that trains the next generation of NASA's planetary explorers by bridging the gap between scientists and engineers, allowing for participants to learn how to design a mission and build a spacecraft in a collaborative and fast-pace environment.

Teledyne Energy Systems, Inc., Proton Exchange Member (PEM) Fuel Cell Engineering Model Powerplant. Test Report: Initial Benchmark Tests in the Original Orientation

NASA Technical Reports Server (NTRS)

Loyselle, Patricia; Prokopius, Kevin

2011-01-01

Proton Exchange Membrane (PEM) fuel cell technology is the leading candidate to replace the alkaline fuel cell technology, currently used on the Shuttle, for future space missions. During a 5-yr development program, a PEM fuel cell powerplant was developed. This report details the initial performance evaluation test results of the powerplant.

A new proton fluence model for E greater than 10 MeV

NASA Technical Reports Server (NTRS)

Feynman, Joan; Armstrong, T. P.; Dao-Gibner, L.; Silverman, S.

1988-01-01

Researchers describe a new engineering model for the fluence of protons with energies greater than 10 MeV. The data set used is a combination of observations made primarily from the Earth's surface between 1956 and 1963 and observations made from spacecraft in the vicinity of Earth between 1963 and 1985. With this data set we find that the distinction between ordinary proton events and anomalously large proton events made in earlier work disappears. The greater than 10 MeV fluences at 1 AU calculated with the new model are about twice those expected on the basis of models now in use. In contrast to earlier models, results do not depend critically on the fluence from any one event.

Potential of proton-pumping rhodopsins: engineering photosystems into microorganisms.

PubMed

Claassens, Nico J; Volpers, Michael; dos Santos, Vitor A P Martins; van der Oost, John; de Vos, Willem M

2013-11-01

A wide range of proton-pumping rhodopsins (PPRs) have been discovered in recent years. Using a synthetic biology approach, PPR photosystems with different features can be easily introduced in nonphotosynthetic microbial hosts. PPRs can provide hosts with the ability to harvest light and drive the sustainable production of biochemicals or biofuels. PPRs use light energy to generate an outward proton flux, and the resulting proton motive force can subsequently power cellular processes. Recently, the introduction of PPRs in microbial production hosts has successfully led to light-driven biotechnological conversions. In this review, we discuss relevant features of natural PPRs, evaluate reported biotechnological applications of microbial production hosts equipped with PPRs, and provide an outlook on future developments. Copyright © 2013 Elsevier Ltd. All rights reserved.

Compression Ignition Engines – Revolutionary Technology That has Civilized Frontiers all Over the Globe from the Industrial Revolution into the Twenty-First Century

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ciatti, Stephen A.

The history, present and future of the compression ignition engine is a fascinating story that spans over 100 years, from the time of Rudolf Diesel to the highly regulated and computerized engines of the 21st Century. The development of these engines provided inexpensive, reliable and high power density machines to allow transportation, construction and farming to be more productive with less human effort than in any previous period of human history. The concept that fuels could be consumed efficiently and effectively with only the ignition of pressurized and heated air was a significant departure from the previous coal-burning architecture ofmore » the 1800s. Today, the compression ignition engine is undergoing yet another revolution. The equipment that provides transport, builds roads and infrastructure, and harvests the food we eat needs to meet more stringent requirements than ever before. How successfully 21st Century engineers are able to make compression ignition engine technology meet these demands will be of major influence in assisting developing nations (with over 50% of the world’s population) achieve the economic and environmental goals they seek.« less

Learning to Be Homesteaders: Frontier Women in Oklahoma

ERIC Educational Resources Information Center

Smith, Joan

2010-01-01

In "The Female Frontier" (1988), Glenda Riley notes that the typical historical account of life on the frontier puts men at the center of the experience. In contrast to a male frontier thesis, Riley posits that women played highly significant, though largely domestic, roles in the settling and development of the frontier, and that…

Engineering the Big Chill: The story of JLab’s Central Helium Liquefier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westfall, Catherine

This article tells the story of the Central Helium Liquefier (CHL) at the Thomas Jefferson National Accelerator Facility (JLab), one of the US National Laboratories. JLab’s successful superconducting radio frequency accelerator was only possible because a group of JLab engineers successfully tackled a complex of difficulties to build a cryogenic system that included the CHL, a task that required advancing the frontier of cryogenic technology. Ultimately, these cryogenic advances were applied far beyond JLab to the benefit of cutting-edge programs at other US national laboratories (Oak Ridge, Brookhaven, and the Facility for Rare Isotope Beams at MSU) as well asmore » NASA. In addition, this innovation story dramatizes the sort of engineer-driven technological problem solving that allows the successful launch and operation of experimental projects. Along the way, the CHL story also provides an important addition to our understanding of the role played by engineers and industry in creating knowledge at physics laboratories.« less

Engineering the Big Chill: The story of JLab’s Central Helium Liquefier

DOE PAGES

Westfall, Catherine

2014-03-29

This article tells the story of the Central Helium Liquefier (CHL) at the Thomas Jefferson National Accelerator Facility (JLab), one of the US National Laboratories. JLab’s successful superconducting radio frequency accelerator was only possible because a group of JLab engineers successfully tackled a complex of difficulties to build a cryogenic system that included the CHL, a task that required advancing the frontier of cryogenic technology. Ultimately, these cryogenic advances were applied far beyond JLab to the benefit of cutting-edge programs at other US national laboratories (Oak Ridge, Brookhaven, and the Facility for Rare Isotope Beams at MSU) as well asmore » NASA. In addition, this innovation story dramatizes the sort of engineer-driven technological problem solving that allows the successful launch and operation of experimental projects. Along the way, the CHL story also provides an important addition to our understanding of the role played by engineers and industry in creating knowledge at physics laboratories.« less

Electrolysis-induced protonation of VO2 thin film transistor for the metal-insulator phase modulation

NASA Astrophysics Data System (ADS)

Katase, Takayoshi; Endo, Kenji; Ohta, Hiromichi

2016-02-01

Compared to state-of-the-art modulation techniques, protonation is the most ideal to control the electrical and optical properties of transition metal oxides (TMOs) due to its intrinsic non-volatile operation. However, the protonation of TMOs is not typically utilized for solid-state devices because of imperative high-temperature annealing treatment in hydrogen source. Although one solution for room temperature (RT) protonation of TMOs is liquid-phase electrochemistry, it is unsuited for practical purposes due to liquid-leakage problem. Herein we demonstrate solid-state RT-protonation of vanadium dioxide (VO2), which is a well-known thermochromic TMO. We fabricated the three terminal thin-film-transistor structure on an insulating VO2 film using a water-infiltrated nanoporous glass, which serves as a solid electrolyte. For gate voltage application, water electrolysis and protonation/deprotonation of VO2 film surface occurred, leading to reversible metal-insulator phase conversion of ~11-nm-thick VO2 layer. The protonation was clearly accompanied by the structural change from an insulating monoclinic to a metallic tetragonal phase. Present results offer a new route for the development of electro-optically active solid-state devices with TMO materials by engineering RT protonation.

Band engineering and precipitation enhance thermoelectric performance of SnTe with Zn-doping

NASA Astrophysics Data System (ADS)

Chen, Zhiyu; Wang, Ruifeng; Wang, Guoyu; Zhou, Xiaoyuan; Wang, Zhengshang; Yin, Cong; Hu, Qing; Zhou, Binqiang; Tang, Jun; Ang, Ran

2018-04-01

Not Available Project supported by the National Natural Science Foundation of China (Grant No. 51771126), the Youth Foundation of Science & Technology Department of Sichuan Province, China (Grant No. 2016JQ0051), the Sichuan University Talent Introduction Research Funding (Grand No. YJ201537), the Sichuan University Outstanding Young Scholars Research Funding (Grant No. 2015SCU04A20), the World First-Class University Construction Funding, and the Fundamental and Frontier Research in Chongqing (Grant No. CSTC2015JCYJBX0026).

Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.

PubMed

Hutmacher, Dietmar Werner; Holzapfel, Boris Michael; De-Juan-Pardo, Elena Maria; Pereira, Brooke Anne; Ellem, Stuart John; Loessner, Daniela; Risbridger, Gail Petuna

2015-12-01

In order to progress beyond currently available medical devices and implants, the concept of tissue engineering has moved into the centre of biomedical research worldwide. The aim of this approach is not to replace damaged tissue with an implant or device but rather to prompt the patient's own tissue to enact a regenerative response by using a tissue-engineered construct to assemble new functional and healthy tissue. More recently, it has been suggested that the combination of Synthetic Biology and translational tissue-engineering techniques could enhance the field of personalized medicine, not only from a regenerative medicine perspective, but also to provide frontier technologies for building and transforming the research landscape in the field of in vitro and in vivo disease models. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering.

PubMed

Kirchner, Marion; Schneider, Sabine

2015-11-09

The field of biology has been revolutionized by the recent advancement of an adaptive bacterial immune system as a universal genome engineering tool. Bacteria and archaea use repetitive genomic elements termed clustered regularly interspaced short palindromic repeats (CRISPR) in combination with an RNA-guided nuclease (CRISPR-associated nuclease: Cas) to target and destroy invading DNA. By choosing the appropriate sequence of the guide RNA, this two-component system can be used to efficiently modify, target, and edit genomic loci of interest in plants, insects, fungi, mammalian cells, and whole organisms. This has opened up new frontiers in genome engineering, including the potential to treat or cure human genetic disorders. Now the potential risks as well as the ethical, social, and legal implications of this powerful new technique move into the limelight. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Proton and helium ion radiotherapy for meningioma tumors: a Monte Carlo-based treatment planning comparison.

PubMed

Tessonnier, Thomas; Mairani, Andrea; Chen, Wenjing; Sala, Paola; Cerutti, Francesco; Ferrari, Alfredo; Haberer, Thomas; Debus, Jürgen; Parodi, Katia

2018-01-09

Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoroughly validated both in terms of physical and biological models. Starting from clinical treatment plans of four patients undergoing proton therapy with a fixed relative biological effectiveness (RBE) of 1.1 and a fraction dose of 1.8 Gy(RBE), new treatment plans were optimized with MCTP for both protons (with variable and fixed RBE) and helium ions (with variable RBE) under the same constraints derived from the initial clinical plans. The resulting dose distributions were dosimetrically compared in terms of dose volume histograms (DVH) parameters for the planning target volume (PTV) and the organs at risk (OARs), as well as dose difference maps. In most of the cases helium ion plans provided a similar PTV coverage as protons with a consistent trend of superior OAR sparing. The latter finding was attributed to the ability of helium ions to offer sharper distal and lateral dose fall-offs, as well as a more favorable differential RBE variation in target and normal tissue. Although more studies are needed to investigate the clinical potential of helium ions for different tumour entities, the results of this work based on an experimentally validated MC engine support the promise of this modality with state-of-the-art pencil beam scanning delivery, especially in case of tumours growing in close proximity of multiple OARs such as meningiomas.

Numerical Simulations of Free Surface Magnetohydrodynamic Flows

NASA Astrophysics Data System (ADS)

Samulyak, Roman; Glimm, James; Oh, Wonho; Prykarpatskyy, Yarema

2003-11-01

We have developed a numerical algorithm and performed simulations of magnetohydrodynamic (MHD) free surface flows. The corresponding system of MHD equations is a system of strongly coupled hyperbolic and parabolic/elliptic equations in moving and geometrically complex domains. The hyperbolic system is solved using the front tracking technique for the free fluid interface. Parallel algorithms for solving elliptic and parabolic equations are based on a finite element discretization on moving grids dynamically conforming to fluid interfaces. The method has been implemented as an MHD extension of the FronTier code. The code has been applied for modeling the behavior of lithium and mercury jets in magnetic fields, laser ablation plumes, and the Richtmyer-Meshkov instability of a liquid mercury jet interacting with a high energy proton pulse in a strong magnetic field. Such an instability occurs in the target for the Muon Collider.

For AAPT: Teaching the Wave Mechanics of McLeods' Stringy Electron, Explicit Nucleons, and Through-the-Earth Projections of Constellations' Stick Figures

NASA Astrophysics Data System (ADS)

McLeod, David Matthew

2011-11-01

McLeods' NEF11#22 submission is from their same-title INVITED presentation at Frontiers in Optics 2011, San Jose, CA. It shows how Hooke's law for electron, proton and neutron strings build electromagnetic waves from strings. These are composed of spirally linked, parallel, north-pole oriented, neutrino and antineutrino strings, stable because of magnetic repulsions. Their Dumbo Proton is antineutrino-scissor cut, and compressed in the vicinity of a neutron star, where electrostatic marriage occurs with a neutrino-scissor cut, and compressed, electron, so a Mickey Neutron emerges. Strings then predict electron charge is -- 1/3 e, Dumbo P is 25 % longer than Mickey N, and Hooke says relaxing springs fuel three separate inflations after each Big Bang oscillation. Gravity can be strings longitudinally linked. Einstein says Herman Grid's black diagonals prove human vision reads its information from algebraically-signed electromagnetic field diffraction patterns known by ray-tracing, not difficult Spatial Fourier Transformation. High-schoolers understand its application to Wave Mechanics, and agree that positive-numbered probabilities do not enter to possibly displease God. Stick figure constellations detected, like Phoenix, Leo, Canis Major, and especially Orion, fool some observers into false beliefs in things like UFHumanoids, or Kokopelli, Pele and Pamola!

Synthesis, Spectra, and Theoretical Investigations of 1,3,5-Triazines Compounds as Ultraviolet Rays Absorber Based on Time-Dependent Density Functional Calculations and three-Dimensional Quantitative Structure-Property Relationship.

PubMed

Wang, Xueding; Xu, Yilian; Yang, Lu; Lu, Xiang; Zou, Hao; Yang, Weiqing; Zhang, Yuanyuan; Li, Zicheng; Ma, Menglin

2018-03-01

A series of 1,3,5-triazines were synthesized and their UV absorption properties were tested. The computational chemistry methods were used to construct quantitative structure-property relationship (QSPR), which was used to computer aided design of new 1,3,5-triazines ultraviolet rays absorber compounds. The experimental UV absorption data are in good agreement with those predicted data using the Time-dependent density functional theory (TD-DFT) [B3LYP/6-311 + G(d,p)]. A suitable forecasting model (R > 0.8, P < 0.0001) was revealed. Predictive three-dimensional quantitative structure-property relationship (3D-QSPR) model was established using multifit molecular alignment rule of Sybyl program, which conclusion is consistent with the TD-DFT calculation. The exceptional photostability mechanism of such ultraviolet rays absorber compounds was studied and confirmed as principally banked upon their ability to undergo excited-state deactivation via an ultrafast excited-state proton transfer (ESIPT). The intramolecular hydrogen bond (IMHB) of 1,3,5-triazines compounds is the basis for the excited state proton transfer, which was explored by IR spectroscopy, UV spectra, structural and energetic aspects of different conformers and frontier molecular orbitals analysis.

Proton Beam Intensity Upgrades for the Neutrino Program at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, C. M.

2016-12-15

Fermilab is committed to upgrading its accelerator complex towards the intensity frontier to pursue HEP research in the neutrino sector and beyond. The upgrade has two steps: 1) the Proton Improvement Plan (PIP), which is underway, has its primary goal to start providing 700 kW beam power on NOvA target by the end of 2017 and 2) the foreseen PIP–II will replace the existing LINAC, a 400 MeV injector to the Booster, by an 800 MeV superconducting LINAC by the middle of next decade, with output beam intensity from the Booster increased significantly and the beam power on the NOvAmore » target increased to <1.2 MW. In any case, the Fermilab Booster is going to play a very significant role for the next two decades. In this context, we have recently developed and commissioned an innovative beam injection scheme for the Booster called "early injection scheme". This scheme is already in operation and has a potential to increase the Booster beam intensity from the PIP design goal by a considerable amount with a reduced beam emittance and beam loss. In this paper, we will present results from our experience from the new scheme in operation, current status and future plans.« less

Medium Effects are as Important as Catalyst Design for Selectivity in Electrocatalytic Oxygen Reduction by Iron-porphyrin Complexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rigsby, Matthew L.; Wasylenko, Derek J.; Pegis, Michael L.

2015-04-08

Several substituted iron porphyrin com-plexes were evaluated for oxygen reduction reaction (ORR) electrocatalysis in different homogeneous and heterogeneous media. The selectivity for 4-electron re-duction to H2O vs. 2-electron reduction to H2O2 varies substantially from one medium to another for a given catalyst. In many cases, the influence of the medium in which the catalyst is evaluated has a larger effect on the observed selectivity than the factors attributable to chemical modification of the catalyst. For instance, introduction of potential proton relays has variable effects depending on the catalyst medium. Thus, comparisons of ORR selectivity results need to be interpreted withmore » caution, as the catalysis is a property not just of the catalyst, but also of the larger mesoscale environment be-yond the catalyst. Still, in all the direct pairwise comparisons in the same medium, the catalysts with potential proton relays have similar or better selectivity for the preferred 4e– path. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences.« less

Early Beam Injection Scheme for the Fermilab Booster: A Path for Intensity Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, C. M.

Over the past decade, Fermilab has focused efforts on the intensity frontier physics and is committed to increase the average beam power delivered to the neutrino and muon programs substantially. Many upgrades to the existing injector accelerators, namely, the current 400 MeV LINAC and the Booster, are in progress under the Proton Improvement Plan (PIP). Proton Improvement Plan-II (PIP-II) proposes to replace the existing 400 MeV LINAC by a new 800 MeV LINAC, as an injector to the Booster which will increase Booster output power by nearly a factor of two from the PIP design value by the end ofmore » its completion. In any case, the Fermilab Booster is going to play a very significant role for nearly next two decades. In this context, I have developed and investigated a new beam injection scheme called "early injection scheme" (EIS) for the Booster with the goal to significantly increase the beam intensity output from the Booster thereby increasing the beam power to the HEP experiments even before PIP-II era. The scheme, if implemented, will also help improve the slip-stacking efficiency in the MI/RR. Here I present results from recent simulations, beam studies, current status and future plans for the new scheme.« less

Design of a High Luminosity 100 TeV Proton-Antiproton Collider

NASA Astrophysics Data System (ADS)

Oliveros Tautiva, Sandra Jimena

Currently new physics is being explored with the Large Hadron Collider at CERN and with Intensity Frontier programs at Fermilab and KEK. The energy scale for new physics is known to be in the multi-TeV range, signaling the need for a future collider which well surpasses this energy scale. A 10 34 cm-2 s-1 luminosity 100 TeV proton-antiproton collider is explored with 7x the energy of the LHC. The dipoles are 4.5 T to reduce cost. A proton-antiproton collider is selected as a future machine for several reasons. The cross section for many high mass states is 10 times higher in pp than pp collisions. Antiquarks for production can come directly from an antiproton rather than indirectly from gluon splitting. The higher cross sections reduce the synchrotron radiation in superconducting magnets and the number of events per bunch crossing, because lower beam currents can produce the same rare event rates. Events are also more centrally produced, allowing a more compact detector with less space between quadrupole triplets and a smaller beta* for higher luminosity. To adjust to antiproton beam losses (burn rate), a Fermilab-like antiproton source would be adapted to disperse the beam into 12 different momentum channels, using electrostatic septa, to increase antiproton momentum capture 12 times. At Fermilab, antiprotons were stochastically cooled in one Debuncher and one Accumulator ring. Because the stochastic cooling time scales as the number of particles, two options of 12 independent cooling systems are presented. One electron cooling ring might follow the stochastic cooling rings for antiproton stacking. Finally antiprotons in the collider ring would be recycled during runs without leaving the collider ring, by joining them to new bunches with snap bunch coalescence and synchrotron damping. These basic ideas are explored in this work on a future 100 TeV proton-antiproton collider and the main parameters are presented.

Design of a High Luminosity 100 TeV Proton Antiproton Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oliveros Tuativa, Sandra Jimena

2017-04-01

Currently new physics is being explored with the Large Hadron Collider at CERN and with Intensity Frontier programs at Fermilab and KEK. The energy scale for new physics is known to be in the multi-TeV range, signaling the need for a future collider which well surpasses this energy scale. A 10more » $$^{\\,34}$$ cm$$^{-2}$$ s$$^{-1}$$ luminosity 100 TeV proton-antiproton collider is explored with 7$$\\times$$ the energy of the LHC. The dipoles are 4.5\\,T to reduce cost. A proton-antiproton collider is selected as a future machine for several reasons. The cross section for many high mass states is 10 times higher in $$p\\bar{p}$$ than $pp$ collisions. Antiquarks for production can come directly from an antiproton rather than indirectly from gluon splitting. The higher cross sections reduce the synchrotron radiation in superconducting magnets and the number of events per bunch crossing, because lower beam currents can produce the same rare event rates. Events are also more centrally produced, allowing a more compact detector with less space between quadrupole triplets and a smaller $$\\beta^{*}$$ for higher luminosity. To adjust to antiproton beam losses (burn rate), a Fermilab-like antiproton source would be adapted to disperse the beam into 12 different momentum channels, using electrostatic septa, to increase antiproton momentum capture 12 times. At Fermilab, antiprotons were stochastically cooled in one Debuncher and one Accumulator ring. Because the stochastic cooling time scales as the number of particles, two options of 12 independent cooling systems are presented. One electron cooling ring might follow the stochastic cooling rings for antiproton stacking. Finally antiprotons in the collider ring would be recycled during runs without leaving the collider ring, by joining them to new bunches with snap bunch coalescence and synchrotron damping. These basic ideas are explored in this work on a future 100 TeV proton-antiproton collider and the main parameters are presented.« less

Research in High Energy Physics at Duke University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kotwal, Ashutosh V.; Goshaw, Al; Kruse, Mark

2013-07-29

This is the Closeout Report for the research grant in experimental elementary particle physics, carried out by the Duke University High Energy Physics (HEP) group. We re- port on physics results and detector development carried out under this grant, focussing on the recent three-year grant period (2010 to 2013). The Duke HEP group consisted of seven faculty members, two senior scientists, ve postdocs and eight graduate students. There were three thrusts of the research program. Measurements at the energy frontier at CDF and ATLAS were used to test aspects of elementary particle theory described by the Stan- dard Model (SM)more » and to search for new forces and particles beyond those contained within the SM. The neutrino sector was explored using data obtained from a large neutrino detector located in Japan, and R & D was conducted on new experiments to be built in the US. The measurements provided information about neutrino masses and the manner in which neutri- nos change species in particle beams. Two years ago we have started a new research program in rare processes based on the Mu2E experiment at Fermilab. This research is motivated by the search for the ! e transition with unprecedented sensitivity, a transition forbidden in the standard model but allowed in supersymmetric and other models of new physics. The high energy research program used proton and antiproton colliding beams. The experiments were done at the Fermilab Tevatron (proton-antiproton collisions at a center of mass energy of 1.96 TeV) and at the CERN Large Hadron Collider (proton-proton collisions at 7-8 TeV). The neutrino program used data obtained from the Super-Kamiokande detec- tor. This water- lled Cherenkov counter was used to detect and measure the properties of neutrinos produced in cosmic ray showers, and from neutrino beams produced from acceler- ators in Japan. The Mu2E experiment will use a special stopped muon beam to be built at Fermilab.« less

Research in High Energy Physics at Duke University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goshaw, Alfred; Kotwal, Ashutosh; Kruse, Mark

2013-07-29

This is the Closeout Report for the research grant in experimental elementary particle physics, carried out by the Duke University High Energy Physics (HEP) group. We re- port on physics results and detector development carried out under this grant, focussing on the recent three-year grant period (2010 to 2013). The Duke HEP group consisted of seven faculty members, two senior scientists, five postdocs and eight graduate students. There were three thrusts of the research program. Measurements at the energy frontier at CDF and ATLAS were used to test aspects of elementary particle theory described by the Stan- dard Model (SM)more » and to search for new forces and particles beyond those contained within the SM. The neutrino sector was explored using data obtained from a large neutrino detector located in Japan, and R & D was conducted on new experiments to be built in the US. The measurements provided information about neutrino masses and the manner in which neutri- nos change species in particle beams. Two years ago we have started a new research program in rare processes based on the Mu2E experiment at Fermilab. This research is motivated by the search for the {mu} {yields} e transition with unprecedented sensitivity, a transition forbidden in the standard model but allowed in supersymmetric and other models of new physics. The high energy research program used proton and antiproton colliding beams. The experiments were done at the Fermilab Tevatron (proton-antiproton collisions at a center of mass energy of 1.96 TeV) and at the CERN Large Hadron Collider (proton-proton collisions at 7-8 TeV). The neutrino program used data obtained from the Super-Kamiokande detector. This water-filled Cherenkov counter was used to detect and measure the properties of neutrinos produced in cosmic ray showers, and from neutrino beams produced from acceler- ators in Japan. The Mu2E experiment will use a special stopped muon beam to be built at Fermilab.« less

Modular extracellular sensor architecture for engineering mammalian cell-based devices.

PubMed

Daringer, Nichole M; Dudek, Rachel M; Schwarz, Kelly A; Leonard, Joshua N

2014-12-19

Engineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision will require new technologies enabling engineered circuitry to sense and respond to physiologically relevant cues. No existing technology enables an engineered cell to sense exclusively extracellular ligands, including proteins and pathogens, without relying upon native cellular receptors or signal transduction pathways that may be subject to crosstalk with native cellular components. To address this need, we here report a technology we term a Modular Extracellular Sensor Architecture (MESA). This self-contained receptor and signal transduction platform is maximally orthogonal to native cellular processes and comprises independent, tunable protein modules that enable performance optimization and straightforward engineering of novel MESA that recognize novel ligands. We demonstrate ligand-inducible activation of MESA signaling, optimization of receptor performance using design-based approaches, and generation of MESA biosensors that produce outputs in the form of either transcriptional regulation or transcription-independent reconstitution of enzymatic activity. This systematic, quantitative platform characterization provides a framework for engineering MESA to recognize novel ligands and for integrating these sensors into diverse mammalian synthetic biology applications.

High Energy Physics

Science.gov Websites

Collider Physics Cosmic Frontier Cosmic Frontier Theory & Computing Detector R&D Electronic Design Theory Seminar Argonne >High Energy Physics Cosmic Frontier Theory & Computing Homepage General Cosmic Frontier Theory & Computing Group led the analysis to begin mapping dark matter. There have

Identifying involvement of Lys251/Asp252 pair in electron transfer and associated proton transfer at the quinone reduction site of Rhodobacter capsulatus cytochrome bc1.

PubMed

Kuleta, Patryk; Sarewicz, Marcin; Postila, Pekka; Róg, Tomasz; Osyczka, Artur

2016-10-01

Describing dynamics of proton transfers in proteins is challenging, but crucial for understanding processes which use them for biological functions. In cytochrome bc1, one of the key enzymes of respiration or photosynthesis, proton transfers engage in oxidation of quinol (QH2) and reduction of quinone (Q) taking place at two distinct catalytic sites. Here we evaluated by site-directed mutagenesis the contribution of Lys251/Asp252 pair (bacterial numbering) in electron transfers and associated with it proton uptake to the quinone reduction site (Qi site). We showed that the absence of protonable group at position 251 or 252 significantly changes the equilibrium levels of electronic reactions including the Qi-site mediated oxidation of heme bH, reverse reduction of heme bH by quinol and heme bH/Qi semiquinone equilibrium. This implicates the role of H-bonding network in binding of quinone/semiquinone and defining thermodynamic properties of Q/SQ/QH2 triad. The Lys251/Asp252 proton path is disabled only when both protonable groups are removed. With just one protonable residue from this pair, the entrance of protons to the catalytic site is sustained, albeit at lower rates, indicating that protons can travel through parallel routes, possibly involving water molecules. This shows that proton paths display engineering tolerance for change as long as all the elements available for functional cooperation secure efficient proton delivery to the catalytic site. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Fitting of full Cobb-Douglas and full VRTS cost frontiers by solving goal programming problem

NASA Astrophysics Data System (ADS)

Venkateswarlu, B.; Mahaboob, B.; Subbarami Reddy, C.; Madhusudhana Rao, B.

2017-11-01

The present research article first defines two popular production functions viz, Cobb-Douglas and VRTS production frontiers and their dual cost functions and then derives their cost limited maximal outputs. This paper tells us that the cost limited maximal output is cost efficient. Here the one side goal programming problem is proposed by which the full Cobb-Douglas cost frontier, full VRTS frontier can be fitted. This paper includes the framing of goal programming by which stochastic cost frontier and stochastic VRTS frontiers are fitted. Hasan et al. [1] used a parameter approach Stochastic Frontier Approach (SFA) to examine the technical efficiency of the Malaysian domestic banks listed in the Kuala Lumpur stock Exchange (KLSE) market over the period 2005-2010. AshkanHassani [2] exposed Cobb-Douglas Production Functions application in construction schedule crashing and project risk analysis related to the duration of construction projects. Nan Jiang [3] applied Stochastic Frontier analysis to a panel of New Zealand dairy forms in 1998/99-2006/2007.

Proton Induced X-Ray Emission (PIXE): Determining the Concentration of Samples

NASA Astrophysics Data System (ADS)

McCarthy, Mallory; Rodriguez Manso, Alis; Pajouhafsar, Yasmin; J Yennello, Sherry

2017-09-01

We used Proton Induced X-ray Emission (PIXE) as an analysis technique to determine the composition of samples, in particular, the elemental constituents and the concentrations. Each of the samples are bombarded with protons, which in result displaces a lower level electron and causes a higher level electron to fall into its place. This displacement produces characteristic x-rays that are `fingerprints' for each element. The protons supplied for the bombardment are produced and accelerated by the K150 proton beam in the Cyclotron Institute at Texas A&M University. The products are detected by three x-ray detectors: XR-100CR Si-PIN, XR-100SDD, and XR-100T CdTe. The peaks of the spectrum are analyzed using a software analysis tool, GUPIXWIN, to determine the concentration of the known elements of each particular sample. The goals of this work are to test run the Proton Induced X-Ray Emission experimental set up at Texas A&M University (TAMU) and to determine the concentration of thin films containing KBr given by the TAMU Chemical Engineering Department.

High frequency ultrasound: a new frontier for ultrasound.

PubMed

Shung, K; Cannata, Jonathan; Qifa Zhou, Member; Lee, Jungwoo

2009-01-01

High frequency ultrasonic imaging is considered by many to be the next frontier in ultrasonic imaging because higher frequencies yield much improved spatial resolution by sacrificing the depth of penetration. It has many clinical applications including visualizing blood vessel wall, anterior segments of the eye and skin. Another application is small animal imaging. Ultrasound is especially attractive in imaging the heart of a small animal like mouse which has a size in the mm range and a heart beat rate faster than 600 BPM. A majority of current commercial high frequency scanners often termed "ultrasonic backscatter microscope or UBM" acquire images by scanning single element transducers at frequencies between 50 to 80 MHz with a frame rate lower than 40 frames/s, making them less suitable for this application. High frequency linear arrays and linear array based ultrasonic imaging systems at frequencies higher than 30 MHz are being developed. The engineering of such arrays and development of high frequency imaging systems has been proven to be highly challenging. High frequency ultrasound may find other significant biomedical applications. The development of acoustic tweezers for manipulating microparticles is such an example.

Alloying of steel and graphite by hydrogen in nuclear reactor

NASA Astrophysics Data System (ADS)

Krasikov, E.

2017-02-01

In traditional power engineering hydrogen may be one of the first primary source of equipment damage. This problem has high actuality for both nuclear and thermonuclear power engineering. Study of radiation-hydrogen embrittlement of the steel raises the question concerning the unknown source of hydrogen in reactors. Later unexpectedly high hydrogen concentrations were detected in irradiated graphite. It is necessary to look for this source of hydrogen especially because hydrogen flakes were detected in reactor vessels of Belgian NPPs. As a possible initial hypothesis about the enigmatical source of hydrogen one can propose protons generation during beta-decay of free neutrons поскольку inasmuch as protons detected by researches at nuclear reactors as witness of beta-decay of free neutrons.

Real-time analysis of organic compounds in ship engine aerosol emissions using resonance-enhanced multiphoton ionisation and proton transfer mass spectrometry.

PubMed

Radischat, Christian; Sippula, Olli; Stengel, Benjamin; Klingbeil, Sophie; Sklorz, Martin; Rabe, Rom; Streibel, Thorsten; Harndorf, Horst; Zimmermann, Ralf

2015-08-01

Organic combustion aerosols from a marine medium-speed diesel engine, capable to run on distillate (diesel fuel) and residual fuels (heavy fuel oil), were investigated under various operating conditions and engine parameters. The online chemical characterisation of the organic components was conducted using a resonance-enhanced multiphoton ionisation time-of-flight mass spectrometer (REMPI TOF MS) and a proton transfer reaction-quadrupole mass spectrometer (PTR-QMS). Oxygenated species, alkenes and aromatic hydrocarbons were characterised. Especially the aromatic hydrocarbons and their alkylated derivatives were very prominent in the exhaust of both fuels. Emission factors of known health-hazardous compounds (e.g. mono- and poly-aromatic hydrocarbons) were calculated and found in higher amounts for heavy fuel oil (HFO) at typical engine loadings. Lower engine loads lead in general to increasing emissions for both fuels for almost every compound, e.g. naphthalene emissions varied for diesel fuel exhaust between 0.7 mg/kWh (75 % engine load, late start of injection (SOI)) and 11.8 mg/kWh (10 % engine load, late SOI) and for HFO exhaust between 3.3 and 60.5 mg/kWh, respectively. Both used mass spectrometric techniques showed that they are particularly suitable methods for online monitoring of combustion compounds and very helpful for the characterisation of health-relevant substances. Graphical abstract Three-dimensional REMPI data of organic species in diesel fuel and heavy fuel oil exhaust.

The Neutral Pentaquark

NASA Astrophysics Data System (ADS)

Moon, Russell; Calvo, Fabian; Vasiliev, Victor

2006-04-01

Using the principles of the Vortex Theory, it was discovered that when the gamma ray strikes a nucleon, the positively charged pentaquark [and the K^- meson] had to be created by the collision with neutron. This discovery further reveals that if the gamma ray strikes a proton it can create a Neutral Pentaquark [and a D^+ meson]. The neutral pentaquark will consist of an up, up, down, down, and an anti-charm quark, while the D^+ meson will consist of a charm and an anti-down quark. The neutral pentaquark will later decay into a neutron and D^0 meson. Because the vortex theory also reveals that the strong force couples a proton to a neutron, the neutron that was coupled to the proton in the nucleus will also be found amid the debris particles. 1. R. G. Moon, The Vortex Theory, The Beginning. Gordons Publications of Fort Lauderdale Fla., 2003, 184 pp. 2. R. G. Moon, The Vortex Theory Explains the Quark Theory. Gordons Publications of Fort Lauderdale Fla., 2005, 205 pp. 3. R.G. Moon, V.V. Vasiliev, The bases of the vortex theory, Book of abstracts The 53 International Meeting on Nuclear Spectroscopy and Nuclear structure, NUCLEUS-2003, October 7-10, 2003, Moscow, St.-Petersburg, Russia, 2003, p.251 4. R.G. Moon, V.V. Vasiliev, The Vortex Theory and Some Interaction in Nuclear Physics, Book of abstracts The 54 International Meeting on Nuclear Spectroscopy and Nuclear Structure, NUCLEUS-2004, June 22-25, 2004, Belgorod, Russia, 2004, p.259 5. R.G. Moon, V.V. Vasiliev. Explanation of the Conservation of Lepton Number, Book of abstracts LV National Conference on Nuclear Physics, Frontiers in the Physics of Nucleus, June 28-July 1, 2005, Saint-Petersburg, Russia, 2005, p. 347

1998 IEEE Aerospace Conference. Proceedings.

NASA Astrophysics Data System (ADS)

The following topics were covered: science frontiers and aerospace; flight systems technologies; spacecraft attitude determination and control; space power systems; smart structures and dynamics; military avionics; electronic packaging; MEMS; hyperspectral remote sensing for GVP; space laser technology; pointing, control, tracking and stabilization technologies; payload support technologies; protection technologies; 21st century space mission management and design; aircraft flight testing; aerospace test and evaluation; small satellites and enabling technologies; systems design optimisation; advanced launch vehicles; GPS applications and technologies; antennas and radar; software and systems engineering; scalable systems; communications; target tracking applications; remote sensing; advanced sensors; and optoelectronics.

Frontier Homes. Save Our History[TM]. Teacher's Guide.

ERIC Educational Resources Information Center

A&E Network, New York, NY.

This lesson plan, based on the Arts and Entertainment documentary "Frontier Homes," consists of four segments which examine a style of historic dwelling built by settlers on the frontier: the post and beam structures built by English settlers in New England; the log houses constructed by pioneers on the forested frontier; sod houses…

A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam

PubMed Central

Terada, K.; Ninomiya, K.; Osawa, T.; Tachibana, S.; Miyake, Y.; Kubo, M. K.; Kawamura, N.; Higemoto, W.; Tsuchiyama, A.; Ebihara, M.; Uesugi, M.

2014-01-01

The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (106 s−1 for a momentum of 60 MeV/c), enabled us to pioneer a new frontier in analytical sciences. Here, we report a non-destructive elemental analysis using µ− capture. Controlling muon momentum from 32.5 to 57.5 MeV/c, we successfully demonstrate a depth-profile analysis of light elements (B, C, N, and O) from several mm-thick layered materials and non-destructive bulk analyses of meteorites containing organic materials. Muon beam analysis, enabling a bulk analysis of light to heavy elements without severe radioactivation, is a unique analytical method complementary to other non-destructive analyses. Furthermore, this technology can be used as a powerful tool to identify the content and distribution of organic components in future asteroidal return samples. PMID:24861282

Research and Development of Wires and Cables for High-Field Accelerator Magnets

DOE PAGES

Barzi, Emanuela; Zlobin, Alexander V.

2016-02-18

The latest strategic plans for High Energy Physics endorse steadfast superconducting magnet technology R&D for future Energy Frontier Facilities. This includes 10 to 16 T Nb3Sn accelerator magnets for the luminosity upgrades of the Large Hadron Collider and eventually for a future 100 TeV scale proton-protonmore » $(pp)$ collider. This paper describes the multi-decade R&D investment in the $$Nb_3Sn$$ superconductor technology, which was crucial to produce the first reproducible 10 to 12 T accelerator-quality dipoles and quadrupoles, as well as their scale-up. We also indicate prospective research areas in superconducting $$Nb_3Sn$$ wires and cables to achieve the next goals for superconducting accelerator magnets. Emphasis is on increasing performance and decreasing costs while pushing the $$Nb_3Sn$$ technology to its limits for future $pp$ colliders.« less

A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam.

PubMed

Terada, K; Ninomiya, K; Osawa, T; Tachibana, S; Miyake, Y; Kubo, M K; Kawamura, N; Higemoto, W; Tsuchiyama, A; Ebihara, M; Uesugi, M

2014-05-27

The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (10(6) s(-1) for a momentum of 60 MeV/c), enabled us to pioneer a new frontier in analytical sciences. Here, we report a non-destructive elemental analysis using µ(-) capture. Controlling muon momentum from 32.5 to 57.5 MeV/c, we successfully demonstrate a depth-profile analysis of light elements (B, C, N, and O) from several mm-thick layered materials and non-destructive bulk analyses of meteorites containing organic materials. Muon beam analysis, enabling a bulk analysis of light to heavy elements without severe radioactivation, is a unique analytical method complementary to other non-destructive analyses. Furthermore, this technology can be used as a powerful tool to identify the content and distribution of organic components in future asteroidal return samples.

Pion Total Cross Section in Nucleon - Nucleon Collisions

NASA Technical Reports Server (NTRS)

Norbury, John W.

2009-01-01

Total cross section parameterizations for neutral and charged pion production in nucleon - nucleon collisions are compared to experimental data over the projectile momentum range from threshold to 300 GeV. Both proton - proton and proton - neutron reactions are considered. Overall excellent agreement between parameterizations and experiment is found, except for notable disagreements near threshold. In addition, the hypothesis that the neutral pion production cross section can be obtained from the average charged pion cross section is checked. The theoretical formulas presented in the paper obey this hypothesis for projectile momenta below 500 GeV. The results presented provide a test of engineering tools used to calculate the pion component of space radiation.

New frontiers in design synthesis

NASA Technical Reports Server (NTRS)

Goldin, D. S.; Venneri, S. L.; Noor, A. K.

1999-01-01

The Intelligent Synthesis Environment (ISE), which is one of the major strategic technologies under development at NASA centers and the University of Virginia, is described. One of the major objectives of ISE is to significantly enhance the rapid creation of innovative affordable products and missions. ISE uses a synergistic combination of leading-edge technologies, including high performance computing, high capacity communications and networking, human-centered computing, knowledge-based engineering, computational intelligence, virtual product development, and product information management. The environment will link scientists, design teams, manufacturers, suppliers, and consultants who participate in the mission synthesis as well as in the creation and operation of the aerospace system. It will radically advance the process by which complex science missions are synthesized, and high-tech engineering Systems are designed, manufactured and operated. The five major components critical to ISE are human-centered computing, infrastructure for distributed collaboration, rapid synthesis and simulation tools, life cycle integration and validation, and cultural change in both the engineering and science creative process. The five components and their subelements are described. Related U.S. government programs are outlined and the future impact of ISE on engineering research and education is discussed.

Engineering excellence in breakthrough biomedical technologies: bioengineering at the University of California, Riverside.

PubMed

Schultz, Jane S; Rodgers, V G J

2012-07-01

The Department of Bioengineering at the University of California, Riverside (UCR), was established in 2006 and is the youngest department in the Bourns College of Engineering. It is an interdisciplinary research engine that builds strength from highly recognized experts in biochemistry, biophysics, biology, and engineering, focusing on common critical themes. The range of faculty research interests is notable for its diversity, from the basic cell biology through cell function to the physiology of the whole organism, each directed at breakthroughs in biomedical devices for measurement and therapy. The department forges future leaders in bioengineering, mirroring the field in being energetic, interdisciplinary, and fast moving at the frontiers of biomedical discoveries. Our educational programs combine a solid foundation in bio logical sciences and engineering, diverse communication skills, and training in the most advanced quantitative bioengineering research. Bioengineering at UCR also includes the Bioengineering Interdepartmental Graduate (BIG) program. With its slogan Start-Grow-Be-BIG, it is already recognized for its many accomplishments, including being third in the nation in 2011 for bioengineering students receiving National Science Foundation graduate research fellowships as well as being one of the most ethnically inclusive programs in the nation.

Scaffolds for peripheral nerve repair and reconstruction.

PubMed

Yi, Sheng; Xu, Lai; Gu, Xiaosong

2018-06-02

Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous nerve grafting, the current gold standard technique for the treatment of peripheral nerve injury, has many internal disadvantages. Emerging studies showed that tissue engineered nerve graft is an effective substitute to autologous nerves. Tissue engineered nerve graft is generally composed of neural scaffolds and incorporating cells and molecules. A variety of biomaterials have been used to construct neural scaffolds, the main component of tissue engineered nerve graft. Synthetic polymers (e.g. silicone, polyglycolic acid, and poly(lactic-co-glycolic acid)) and natural materials (e.g. chitosan, silk fibroin, and extracellular matrix components) are commonly used along or together to build neural scaffolds. Many other materials, including the extracellular matrix, glass fabrics, ceramics, and metallic materials, have also been used to construct neural scaffolds. These biomaterials are fabricated to create specific structures and surface features. Seeding supporting cells and/or incorporating neurotrophic factors to neural scaffolds further improve restoration effects. Preliminary studies demonstrate that clinical applications of these neural scaffolds achieve satisfactory functional recovery. Therefore, tissue engineered nerve graft provides a good alternative to autologous nerve graft and represents a promising frontier in neural tissue engineering. Copyright © 2018 Elsevier Inc. All rights reserved.

Design of Conventional Submarines with Advanced Air Independent Propulsion Systems and Determination of Corresponding Theater-Level Impacts

DTIC Science & Technology

2010-01-01

rescue vehicle e: Error term ft: Feet HDW: Howaldtswerke- Deutsche Werft GmbH PEMFC : Proton exchange membrane fuel cells IR: Indiscretion rate/ratio...engines &Rankine cycle power plants &Closed cycle engines A PEMFC AIP system is fitted in the 212 class of submarines that German shipbuilders How...bines a conventional system consisting of a diesel engine and a lead acid battery, with the PEMFC AIP system used for slow, silent cruising. The AIP

The offshore petroleum industry: The formative years, 1945-1962

NASA Astrophysics Data System (ADS)

Kreidler, Tai Deckner

1997-12-01

This dissertation is the first to examine the offshore oil industry that was born in the calm waters of the Gulf of Mexico. It describes the industry's origins and tracks its development as a consequence of a search for new oil frontiers. In addition, it elaborates how the oil industry moved into the marine province using available technology, and was driven by the economic urgency to compete and develop new territories. Enterprising drilling contractors and operators seized the offshore gamble, finding it possible to lower the economic and technological threshold by drawing directly from wartime research and surplus equipment. Though large oil companies had placed its indelible stamp upon the industry, the smaller, independent oil operators set the pace of early offshore development. As a technological frontier, offshore development depended upon creative and unconventional engineering. Unfamiliar marine conditions tested the imagination of oil industry engineering. The unorthodox methods of John Hayward of Barnsdall Oil and R. G. LeTourneau of LeTourneau, Inc. among others transformed the industry by blending petroleum and marine engineering. Grappling with alien marine conditions and lacking formal training, Hayward and LeTourneau merged a century of practical oil field knowledge and petroleum engineering with 2,000 years of shipbuilding experience. The Gulf of Mexico served as a fertile and protective environment for the development of a fledgling industry. With calm waters, lacking the tempestuous and stormy character of the Atlantic Ocean, with a gradual sea-floor slope and saturated with the highly productive salt dome reservoirs, the Gulf became the birth place of the modern offshore oil industry. Within its protective sphere, companies experimented and developed various technical and business adaptations. Operators used technology and business strategies that increased the opportunity for success. In addition, regional academic research institutes arose as a response to increasing work done for the offshore industry. Academic areas that developed included oceanography, physical oceanography, marine biology, marine geology, meteorology, and weather forecasting, During the formative era that ended in the late 1950s the industry had formed its technological and economic foundation in the Gulf, and stood poised to seize the initiative in the North Sea, the Middle East, the Far East, and Indonesia.

Quantum tunneling of thermal protons through pristine graphene.

PubMed

Poltavsky, Igor; Zheng, Limin; Mortazavi, Majid; Tkatchenko, Alexandre

2018-05-28

Engineering of atomically thin membranes for hydrogen isotope separation is an actual challenge which has a broad range of applications. Recent experiments [M. Lozada-Hidalgo et al., Science 351, 68 (2016)] unambiguously demonstrate an order-of-magnitude difference in permeabilities of graphene-based membranes to protons and deuterons at ambient conditions, making such materials promising for novel separation technologies. Here we demonstrate that the permeability mechanism in such systems changes from quantum tunneling for protons to quasi-classical transport for heavier isotopes. Quantum nuclear effects exhibit large temperature and mass dependence, modifying the Arrhenius activation energy and Arrhenius prefactor for protons by more than 0.5 eV and by seven orders of magnitude correspondingly. Our findings not only shed light on the separation process for hydrogen isotope ions passing through pristine graphene but also offer new insights for controlling ion transport mechanisms in nanostructured separation membranes by manipulating the shape of the barrier and transport process conditions.

Proton acceleration to above 5.5 MeV by interaction of 1017 W/cm2 laser pulse with H2O nano-wire targets

NASA Astrophysics Data System (ADS)

Schleifer, E.; Bruner, N.; Eisenmann, S.; Botton, M.; Pikuz, S. A., Jr.; Faenov, A. Y.; Gordon, D.; Zigler, A.

2011-05-01

Compact sources of high energy protons (50-500MeV) are expected to be key technology in a wide range of scientific applications 1-8. Particularly promising is the target normal sheah acceleration (TNSA) scheme 9,10, holding record level of 67MeV protons generated by a peta-Watt laser 11. In general, laser intensity exceeding 1018 W/cm2 is required to produce MeV level protons. Enhancing the energy of generated protons using compact laser sources is very attractive task nowadays. Recently, nano-scale targets were used to accelerate ions 12,13. Here we report on the first generation of 5.5-7.5MeV protons by modest laser intensities (4.5 × 1017 W/cm2) interacting with H2O nano-wires (snow) deposited on a Sapphire substrate. In this setup, the plasma near the tip of the nano-wire is subject to locally enhanced laser intensity with high spatial gradients, and confined charge separation is obtained. Electrostatic fields of extremely high intensities are produced, and protons are accelerated to MeV-level energies. Nano-wire engineered targets will relax the demand of peak energy from laser based sources.

Heterolytic Cleavage of H2 by Bifunctional Manganese(I) Complexes: Impact of Ligand Dynamics, Electrophilicity, and Base Positioning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hulley, Elliott B.; Helm, Monte L.; Bullock, R. Morris

2014-12-01

We report the synthesis, characterization, and reactivity with H2 of a series of MnI complexes of the type [(P-P)Mn(L2)CO]+ (L2 = dppm, bppm, or (CO)2; P-P = PPhNMePPh or PPh2 NBn2 ) that bear pendant amine ligands designed to function as proton relays. The pendant amine was found to function as a hemilabile ligand; its binding strength is strongly affected by the ancillary ligand environment around Mn. Tuning the electrophilicity of the Mn center leads to systems capable of reversible heterolytic cleavage of the H-H bond. The strength of pendant amine binding can be balanced to protect the Mn centermore » while still leading to facile reactivity with H2. Neutral amine-bearing MnIH species were found to react with one-electron oxidants and, after proton and electron transfer reactions, regenerate MnI cationic species. The reactivity presented herein indicate that the Mn complexes we have developed are a promising platform for Mn-based H2 oxidation electrocatalyst development. The research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for DOE.« less

The Center for Frontiers of Subsurface Energy Security (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pope, Gary A.

"The Center for Frontiers of Subsurface Energy Security (CFSES)" was submitted to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CFSES is directed by Gary A. Pope at the University of Texas at Austin and partners with Sandia National Laboratories. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conductmore » fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

The Center for Frontiers of Subsurface Energy Security (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Pope, Gary A. (Director, Center for Frontiers of Subsurface Energy Security); CFSES Staff

2017-12-09

'The Center for Frontiers of Subsurface Energy Security (CFSES)' was submitted to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CFSES is directed by Gary A. Pope at the University of Texas at Austin and partners with Sandia National Laboratories. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Energy Frontier Research Center Materials Science of Actinides (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Burns, Peter (Director, Materials Science of Actinides); MSA Staff

2017-12-09

'Energy Frontier Research Center Materials Science of Actinides' was submitted by the EFRC for Materials Science of Actinides (MSA) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. MSA is directed by Peter Burns at the University of Notre Dame, and is a partnership of scientists from ten institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Unifying physical concepts of reality

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbert, T.L.

1983-08-01

Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large andmore » the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.« less

Systems Engineering Using Heritage Spacecraft Technology: Lessons Learned from Discovery and New Frontiers Deep Space Missions

NASA Technical Reports Server (NTRS)

Barley, Bryan; Newhouse, Marilyn; Clardy, Dennon

2011-01-01

In the design and development of complex spacecraft missions, project teams frequently assume the use of advanced technology or heritage systems to enable a mission or reduce the overall mission risk and cost. As projects proceed through the development life cycle, increasingly detailed knowledge of the advanced or heritage systems and the system environment identifies unanticipated issues that result in cost overruns or schedule impacts. The Discovery & New Frontiers (D&NF) Program Office recently studied cost overruns and schedule delays resulting from advanced technology or heritage assumptions for 6 D&NF missions. The goal was to identify the underlying causes for the overruns and delays, and to develop practical mitigations to assist the D&NF projects in identifying potential risks and controlling the associated impacts to proposed mission costs and schedules. The study found that the cost and schedule growth did not result from technical hurdles requiring significant technology development. Instead, systems engineering processes did not identify critical issues early enough in the design cycle to ensure project schedules and estimated costs address the inherent risks. In general, the overruns were traceable to: inadequate understanding of the heritage system s behavior within the proposed spacecraft design and mission environment; an insufficient level of experience with the heritage system; or an inadequate scoping of the system-wide impacts necessary to implement the heritage or advanced technology. This presentation summarizes the study s findings and offers suggestions for improving the project s ability to identify and manage the risks inherent in the technology and heritage design solution.

Controlling Proton Delivery through Catalyst Structural Dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardenas, Allan Jay P.; Ginovska, Bojana; Kumar, Neeraj

The fastest synthetic molecular catalysts for production and oxidation of H2 emulate components of the active site of natural hydrogenases. The role of controlled structural dynamics is recognized as a critical component in the catalytic performance of many enzymes, including hydrogenases, but is largely neglected in the design of synthetic molecular cata-lysts. In this work, the impact of controlling structural dynamics on the rate of production of H2 was studied for a series of [Ni(PPh2NC6H4-R2)2]2+ catalysts including R = n-hexyl, n-decyl, n-tetradecyl, n-octadecyl, phenyl, or cyclohexyl. A strong correlation was observed between the ligand structural dynamics and the rates ofmore » electrocatalytic hydrogen production in acetonitrile, acetonitrile-water, and protic ionic liquid-water mixtures. Specifically, the turnover frequencies correlate inversely with the rates of ring inversion of the amine-containing ligand, as this dynamic process dictates the positioning of the proton relay in the second coordination sphere and therefore governs protonation at either catalytically productive or non-productive sites. This study demonstrates that the dynamic processes involved in proton delivery can be controlled through modifications of the outer coordination sphere of the catalyst, similar to the role of the protein architecture in many enzymes. The present work provides new mechanistic insight into the large rate enhancements observed in aqueous protic ionic liquid media for the [Ni(PPh2NR2)]2+ family of catalysts. The incorporation of controlled structural dynamics as a design parameter to modulate proton delivery in molecular catalysts has enabled H2 production rates that are up to three orders of magnitude faster than the [Ni(PPh2NPh2)]2+complex. The observed turnover frequencies are up to 106 s-1 in acetonitrile-water, and over 107 s-1 in protic ionic liquid-water mixtures, with a minimal increase in overpotential. This material is based upon work supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, and was performed in part using the Molecular Science Computing Facility (MSCF) in the William R. Wiley Environmental Molecular Sciences Laboratory, a DOE national scientific user facility located at Pacific Northwest National Laboratory (PNNL). PNNL is operated by Battelle for DOE.« less

Onward to Petaflops Computing

NASA Technical Reports Server (NTRS)

Bailey, David H.; Chancellor, Marisa K. (Technical Monitor)

1997-01-01

With programs such as the US High Performance Computing and Communications Program (HPCCP), the attention of scientists and engineers worldwide has been focused on the potential of very high performance scientific computing, namely systems that are hundreds or thousands of times more powerful than those typically available in desktop systems at any given point in time. Extending the frontiers of computing in this manner has resulted in remarkable advances, both in computing technology itself and also in the various scientific and engineering disciplines that utilize these systems. Within the month or two, a sustained rate of 1 Tflop/s (also written 1 teraflops, or 10(exp 12) floating-point operations per second) is likely to be achieved by the 'ASCI Red' system at Sandia National Laboratory in New Mexico. With this objective in sight, it is reasonable to ask what lies ahead for high-end computing.

Topological Acoustic Delay Line

NASA Astrophysics Data System (ADS)

Zhang, Zhiwang; Tian, Ye; Cheng, Ying; Wei, Qi; Liu, Xiaojun; Christensen, Johan

2018-03-01

Topological protected wave engineering in artificially structured media is at the frontier of ongoing metamaterials research that is inspired by quantum mechanics. Acoustic analogues of electronic topological insulators have recently led to a wealth of new opportunities in manipulating sound propagation with strikingly unconventional acoustic edge modes immune to backscattering. Earlier fabrications of topological insulators are characterized by an unreconfigurable geometry and a very narrow frequency response, which severely hinders the exploration and design of useful devices. Here we establish topologically protected sound in reconfigurable phononic crystals that can be switched on and off simply by rotating its three-legged "atoms" without altering the lattice structure. In particular, we engineer robust phase delay defects that take advantage of the ultrabroadband reflection-free sound propagation. Such topological delay lines serve as a paradigm in compact acoustic devices, interconnects, and electroacoustic integrated circuits.

Fuel Cell Propulsion Systems for an All-electric Personal Air Vehicle

NASA Technical Reports Server (NTRS)

Kohout, Lisa L.; Schmitz, Paul C.

2003-01-01

There is a growing interest in the use of fuel cells as a power source for all-electric aircraft propulsion as a means to substantially reduce or eliminate environmentally harmful emissions. Among the technologies under consideration for these concepts are advanced proton exchange membrane and solid oxide fuel cells, alternative fuels and fuel processing, and fuel storage. This paper summarizes the results of a first-order feasibility study for an all-electric personal air vehicle utilizing a fuel cell-powered propulsion system. A representative aircraft with an internal combustion engine was chosen as a baseline to provide key parameters to the study, including engine power and subsystem mass, fuel storage volume and mass, and aircraft range. The engine, fuel tank, and associated ancillaries were then replaced with a fuel cell subsystem. Various configurations were considered including: a proton exchange membrane (PEM) fuel cell with liquid hydrogen storage; a direct methanol PEM fuel cell; and a direct internal reforming solid oxide fuel cell (SOFC)/turbine hybrid system using liquid methane fuel. Each configuration was compared to the baseline case on a mass and range basis.

Fuel Cell Propulsion Systems for an All-Electric Personal Air Vehicle

NASA Technical Reports Server (NTRS)

Kohout, Lisa L.

2003-01-01

There is a growing interest in the use of fuel cells as a power source for all-electric aircraft propulsion as a means to substantially reduce or eliminate environmentally harmful emissions. Among the technologies under consideration for these concepts are advanced proton exchange membrane and solid oxide fuel cells, alternative fuels and fuel processing, and fuel storage. This paper summarizes the results of a first-order feasibility study for an all-electric personal air vehicle utilizing a fuel cell-powered propulsion system. A representative aircraft with an internal combustion engine was chosen as a baseline to provide key parameters to the study, including engine power and subsystem mass, fuel storage volume and mass, and aircraft range. The engine, fuel tank, and associated ancillaries were then replaced with a fuel cell subsystem. Various configurations were considered including: a proton exchange membrane (PEM) fuel cell with liquid hydrogen storage; a direct methanol PEM fuel cell; and a direct internal reforming solid oxide fuel cell (SOFC)/turbine hybrid system using liquid methane fuel. Each configuration was compared to the baseline case on a mass and range basis.

Security in the CernVM File System and the Frontier Distributed Database Caching System

NASA Astrophysics Data System (ADS)

Dykstra, D.; Blomer, J.

2014-06-01

Both the CernVM File System (CVMFS) and the Frontier Distributed Database Caching System (Frontier) distribute centrally updated data worldwide for LHC experiments using http proxy caches. Neither system provides privacy or access control on reading the data, but both control access to updates of the data and can guarantee the authenticity and integrity of the data transferred to clients over the internet. CVMFS has since its early days required digital signatures and secure hashes on all distributed data, and recently Frontier has added X.509-based authenticity and integrity checking. In this paper we detail and compare the security models of CVMFS and Frontier.

Frontier production function estimates for steam electric generation: a comparative analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopp, R.J.; Smith, V.K.

1980-04-01

The performance of three frontier steam electric generation estimators is compared in terms of the consideration given to new production technologies and their technical efficiency. The Cobb-Douglas, constant elasticity of substitution, and translog production functions are examined, using the Aigner-Chu linear programming, the sophisticated Aigner-Lovell-Schmidt stochastic frontier, and the direct method of adjusted ordinary least squares frontier estimators. The use of Cobb-Douglas specification is judged to have narrowed the perceived difference between competing estimators. The choice of frontier estimator is concluded to have a greater effect on the plant efficiency than functional form. 19 references. (DCK)

Energy Frontier Research Center Materials Science of Actinides (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burns, Peter; Lenzen, Meehan

"Energy Frontier Research Center Materials Science of Actinides" was submitted by the EFRC for Materials Science of Actinides (MSA) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. MSA is directed by Peter Burns at the University of Notre Dame, and is a partnership of scientists from ten institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Researchmore » Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

EFRC:CST at the University of Texas at Austin - A DOE Energy Frontier Research Center (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Zhu, Xiaoyang (Director, Understanding Charge Separation and Transfer at Interfaces in Energy Materials); CST Staff

2017-12-09

'EFRC:CST at the University of Texas at Austin - A DOE Energy Frontier Research Center' was submitted by the EFRC for Understanding Charge Separation and Transfer at Interfaces in Energy Materials (EFRC:CST) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFRC:CST is directed by Xiaoyang Zhu at the University of Texas at Austin in partnership with Sandia National Laboratories. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Space and the American imagination

NASA Technical Reports Server (NTRS)

Mccurdy, Howard E.

1994-01-01

The introduction will set out the principal theme of the book: that the rise of the U.S. space program was due to a concerted effort by science writers, engineers, industrialists, and civic and political leaders to create a popular culture of space exploration based on important elements of American social life (such as frontier mythology, fears about the cold war, and the rise of the consumer culture). Much of the disillusionment with the NASA space program which set in during the third decade of space flight can be traced to a widening gap between popular expectations and the reality of space exploration.

Traction studies of piston ring wear using an external radiometric method with proton activation

NASA Astrophysics Data System (ADS)

Scharf, Waldemar; Niewczas, Andrzej

1987-04-01

A method and results are presented of traction studies of piston ring wear in a Polski Fiat 126p passenger car and Star 200 lorry. The rings sliding surface was activated with a beam of 9.6-MeV protons and the measurements were made using a collimated scintillation detector placed outside the engine, i.e. without interfering with the engine's operation. The cars were run under varying traction conditions, their mileages having ranged between 7000 and 12000 km. In stable wear conditions on the road the piston ring wear for the passenger car and the lorry was {0.28%}/{100} km and {0.045%}/{100} km, respectively. The method was found to be particularly suitable for traction studies because it is simple and cheap. It can be employed as early as after the first 100 km of the car mileage.

The reform of the teaching mode of Applied Optics curriculum and analysis of teaching effect

NASA Astrophysics Data System (ADS)

Ning, Yu; Xu, Zhongjie; Li, Dun; Chen, Zilun; Cheng, Xiangai; Zhong, Hairong

2017-08-01

Military academies have two distinctive characteristics on talent training: Firstly, we must teach facing actual combat and connecting with academic frontier. Secondly, the bachelor's degree education and the military education should be balanced. The teaching mode of basic curriculum in military academies must be reformed and optimized on the basis of the traditional teaching mode, so as to ensure the high quality of teaching and provide enough guidance and help for students to support their academic burden. In this paper, our main work on "Applied Optics" teaching mode reform is introduced: First of all, we research extensively and learn fully from advanced teaching modes of the well-known universities at home and abroad, a whole design is made for the teaching mode of the core curriculum of optical engineering in our school "Applied Optics", building a new teaching mode which takes the methods of teaching basic parts as details, teaching application parts as emphases, teaching frontier parts as topics and teaching actual combat parts on site. Then combining with the questionnaire survey of students and opinions proposed by relevant experts in the teaching seminar, teaching effect and generalizability of the new teaching mode are analyzed and evaluated.

Molecular Mapping of Flowering Time Major Genes and QTLs in Chickpea (Cicer arietinum L.)

PubMed Central

Mallikarjuna, Bingi P.; Samineni, Srinivasan; Thudi, Mahendar; Sajja, Sobhan B.; Khan, Aamir W.; Patil, Ayyanagowda; Viswanatha, Kannalli P.; Varshney, Rajeev K.; Gaur, Pooran M.

2017-01-01

Flowering time is an important trait for adaptation and productivity of chickpea in the arid and the semi-arid environments. This study was conducted for molecular mapping of genes/quantitative trait loci (QTLs) controlling flowering time in chickpea using F2 populations derived from four crosses (ICCV 96029 × CDC Frontier, ICC 5810 × CDC Frontier, BGD 132 × CDC Frontier and ICC 16641 × CDC Frontier). Genetic studies revealed monogenic control of flowering time in the crosses ICCV 96029 × CDC Frontier, BGD 132 × CDC Frontier and ICC 16641 × CDC Frontier, while digenic control with complementary gene action in ICC 5810 × CDC Frontier. The intraspecific genetic maps developed from these crosses consisted 75, 75, 68 and 67 markers spanning 248.8 cM, 331.4 cM, 311.1 cM and 385.1 cM, respectively. A consensus map spanning 363.8 cM with 109 loci was constructed by integrating four genetic maps. Major QTLs corresponding to flowering time genes efl-1 from ICCV 96029, efl-3 from BGD 132 and efl-4 from ICC 16641 were mapped on CaLG04, CaLG08 and CaLG06, respectively. The QTLs and linked markers identified in this study can be used in marker-assisted breeding for developing early maturing chickpea. PMID:28729871

Stratigraphy and structural setting of Upper Cretaceous Frontier Formation, western Centennial Mountains, southwestern Montana and southeastern Idaho

USGS Publications Warehouse

Dyman, T.S.; Tysdal, R.G.; Perry, W.J.; Nichols, D.J.; Obradovich, J.D.

2008-01-01

Stratigraphic, sedimentologic, and palynologic data were used to correlate the Frontier Formation of the western Centennial Mountains with time-equivalent rocks in the Lima Peaks area and other nearby areas in southwestern Montana. The stratigraphic interval studied is in the middle and upper parts (but not uppermost) of the formation based on a comparison of sandstone petrography, palynologic age data, and our interpretation of the structure using a seismic line along the frontal zone of the Centennial Mountains and the adjacent Centennial Valley. The Frontier Formation is comprised of sandstone, siltstone, mudstone, limestone, and silty shale in fluvial and coastal depositional settings. A distinctive characteristic of these strata in the western Centennial Mountains is the absence of conglomerate and conglomeratic sandstone beds. Absence of conglomerate beds may be due to lateral facies changes associated with fluvial systems, a distal fining of grain size, and the absence of both uppermost and lower Frontier rocks in the study area. Palynostratigraphic data indicate a Coniacian age for the Frontier Formation in the western Centennial Mountains. These data are supported by a geochronologic age from the middle part of the Frontier at Lima Peaks indicating a possible late Coniacian-early Santonian age (86.25 ?? 0.38 Ma) for the middle Frontier there. The Frontier Formation in the western Centennial Mountains is comparable in age and thickness to part of the Frontier at Lima Peaks. These rocks represent one of the thickest known sequences of Frontier strata in the Rocky Mountain region. Deposition was from about 95 to 86 Ma (middle Cenomanian to at least early Santonian), during which time, shoreface sandstone of the Telegraph Creek Formation and marine shale of the Cody Shale were deposited to the east in the area now occupied by the Madison Range in southwestern Montana. Frontier strata in the western Centennial Mountains are structurally isolated from other Cretaceous rocks in the region and are part of the Lima thrust sheet that lies at the leading edge of the Sevier-style overthrusting in this part of southwestern Montana and adjacent southeastern Idaho.

Emerging CAE technologies and their role in Future Ambient Intelligence Environments

NASA Astrophysics Data System (ADS)

Noor, Ahmed K.

2011-03-01

Dramatic improvements are on the horizon in Computer Aided Engineering (CAE) and various simulation technologies. The improvements are due, in part, to the developments in a number of leading-edge technologies and their synergistic combinations/convergence. The technologies include ubiquitous, cloud, and petascale computing; ultra high-bandwidth networks, pervasive wireless communication; knowledge based engineering; networked immersive virtual environments and virtual worlds; novel human-computer interfaces; and powerful game engines and facilities. This paper describes the frontiers and emerging simulation technologies, and their role in the future virtual product creation and learning/training environments. The environments will be ambient intelligence environments, incorporating a synergistic combination of novel agent-supported visual simulations (with cognitive learning and understanding abilities); immersive 3D virtual world facilities; development chain management systems and facilities (incorporating a synergistic combination of intelligent engineering and management tools); nontraditional methods; intelligent, multimodal and human-like interfaces; and mobile wireless devices. The Virtual product creation environment will significantly enhance the productivity and will stimulate creativity and innovation in future global virtual collaborative enterprises. The facilities in the learning/training environment will provide timely, engaging, personalized/collaborative and tailored visual learning.

Snowmass Computing Frontier: Computing for the Cosmic Frontier, Astrophysics, and Cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connolly, A.; Habib, S.; Szalay, A.

2013-11-12

This document presents (off-line) computing requrements and challenges for Cosmic Frontier science, covering the areas of data management, analysis, and simulations. We invite contributions to extend the range of covered topics and to enhance the current descriptions.

Center for Defect Physics - Energy Frontier Research Center (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Stocks, G. Malcolm (Director, Center for Defect Physics in Structural Materials); CDP Staff

2017-12-09

'Center for Defect Physics - Energy Frontier Research Center' was submitted by the Center for Defect Physics (CDP) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CDP is directed by G. Malcolm Stocks at Oak Ridge National Laboratory, and is a partnership of scientists from nine institutions: Oak Ridge National Laboratory (lead); Ames Laboratory; Brown University; University of California, Berkeley; Carnegie Mellon University; University of Illinois, Urbana-Champaign; Lawrence Livermore National Laboratory; Ohio State University; and University of Tennessee. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

EFRC: CST at the University of Texas at Austin- A DOE Energy Frontier Research Center (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Xiaoyang

"EFRC: CST at the University of Texas at Austin- A DOE Energy Frontier Research Center" was submitted by the EFRC for Understanding Charge Separation and Transfer at Interfaces in Energy Materials (EFRC:CST) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFRC: CST is directed by Xiaoyang Zhu at the University of Texas at Austin in partnership with Sandia National Laboratories. The Office of Basic Energy Sciences in themore » U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Center for Defect Physics - Energy Frontier Research Center (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stocks, G. Malcolm; Ice, Gene

"Center for Defect Physics - Energy Frontier Research Center" was submitted by the Center for Defect Physics (CDP) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CDP is directed by G. Malcolm Stocks at Oak Ridge National Laboratory, and is a partnership of scientists from eight institutions: Oak Ridge National Laboratory (lead); Ames Laboratory; University of California, Berkeley; Carnegie Mellon University; University of Illinois, Urbana-Champaign; Ohio State University;more » University of Georgia and University of Tennessee. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Expanding the frontiers of population nutrition research: new questions, new methods, and new approaches.

PubMed

Pelletier, David L; Porter, Christine M; Aarons, Gregory A; Wuehler, Sara E; Neufeld, Lynnette M

2013-01-01

Nutrition research, ranging from molecular to population levels and all points along this spectrum, is exploring new frontiers as new technologies and societal changes create new possibilities and demands. This paper defines a set of frontiers at the population level that are being created by the increased societal recognition of the importance of nutrition; its connection to urgent health, social, and environmental problems; and the need for effective and sustainable solutions at the population level. The frontiers are defined in terms of why, what, who, and how we study at the population level and the disciplinary foundations for that research. The paper provides illustrations of research along some of these frontiers, an overarching framework for population nutrition research, and access to some of the literature from outside of nutrition that can enhance the intellectual coherence, practical utility, and societal benefit of population nutrition research. The frontiers defined in this paper build on earlier forward-looking efforts by the American Society for Nutrition and extend these efforts in significant ways. The American Society for Nutrition and its members can play pivotal roles in advancing these frontiers by addressing a number of well-recognized challenges associated with transdisciplinary and engaged research.

Proton Radiation Therapy in the Hospital Environment: Conception, Development, and Operation of the Initial Hospital-Based Facility

NASA Astrophysics Data System (ADS)

Slater, James M.; Slater, Jerry D.; Wroe, Andrew J.

The world's first hospital-based proton treatment center opened at Loma Linda University Medical Center in 1990, following two decades of development. Patients' needs were the driving force behind its conception, development, and execution; the primary needs were delivery of effective conformal doses of ionizing radiation and avoidance of normal tissue to the maximum extent possible. The facility includes a proton synchrotron and delivery system developed in collaboration with physicists and engineers at Fermi National Accelerator Laboratory and from other high-energy-physics laboratories worldwide. The system, operated and maintained by Loma Linda personnel, was designed to be safe, reliable, flexible in utilization, efficient in use, and upgradeable to meet demands of changing patient needs and advances in technology. Since the facility opened, nearly 14,000 adults and children have been treated for a wide range of cancers and other diseases. Ongoing research is expanding the applications of proton therapy, while reducing costs.

Community Project for Accelerator Science and Simulation (ComPASS) Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cary, John R.; Cowan, Benjamin M.; Veitzer, S. A.

2016-03-04

Tech-X participated across the full range of ComPASS activities, with efforts in the Energy Frontier primarily through modeling of laser plasma accelerators and dielectric laser acceleration, in the Intensity Frontier primarily through electron cloud modeling, and in Uncertainty Quantification being applied to dielectric laser acceleration. In the following we present the progress and status of our activities for the entire period of the ComPASS project for the different areas of Energy Frontier, Intensity Frontier and Uncertainty Quantification.

jsc2013e018009

NASA Image and Video Library

2013-03-21

Behind their Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 35-36 Flight Engineer Alexander Misurkin (left), Soyuz Commander Pavel Vinogradov (center) and Flight Engineer Chris Cassidy of NASA (right) pose for pictures March 21 by a replica of a Russian Proton rocket as they train for launch to the International Space Station March 29, Kazakh time, in their Soyuz TMA-08M spacecraft from the Baikonur Cosmodrome for a 5 ½ month mission. NASA/Victor Zelentsov

Polymers for Drug Delivery Systems

PubMed Central

Liechty, William B.; Kryscio, David R.; Slaughter, Brandon V.; Peppas, Nicholas A.

2012-01-01

Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery. PMID:22432577

A network engineering perspective on probing and perturbing cognition with neurofeedback

PubMed Central

Khambhati, Ankit N.

2017-01-01

Network science and engineering provide a flexible and generalizable tool set to describe and manipulate complex systems characterized by heterogeneous interaction patterns among component parts. While classically applied to social systems, these tools have recently proven to be particularly useful in the study of the brain. In this review, we describe the nascent use of these tools to understand human cognition, and we discuss their utility in informing the meaningful and predictable perturbation of cognition in combination with the emerging capabilities of neurofeedback. To blend these disparate strands of research, we build on emerging conceptualizations of how the brain functions (as a complex network) and how we can develop and target interventions or modulations (as a form of network control). We close with an outline of current frontiers that bridge neurofeedback, connectomics, and network control theory to better understand human cognition. PMID:28445589

Technology in Sustainable Development Context

NASA Astrophysics Data System (ADS)

Uno, Kimio

The economic and demographic growth in Asia has put increased importance to this part of the world whose contribution to the global community is vital in meeting global challenges. International cooperation in engineering education assumes a pivotal role in providing access to the frontiers of scientific and technological knowledge to the growing youths in the region. The thrust for advancement has been provided by the logic coming from the academic world itself, whereas expectations are high that the engineering education responds to challenges that are coming from outside the universities, such as environmental management, disaster management, and provision of common knowledge platform across disciplinary lines. Some cases are introduced in curriculum development that incorporates fieldwork and laboratory work intended to enhance the ability to cooperate. The new mode is discussed with focus on production, screening, storing/delivery, and leaning phases of knowledge. The strength of shared information will be enhanced through international cooperation.

Epigenetic Regulation: A New Frontier for Biomedical Engineers.

PubMed

Chen, Zhen; Li, Shuai; Subramaniam, Shankar; Shyy, John Y-J; Chien, Shu

2017-06-21

Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer interactions, and noncoding RNA-mediated regulation. The coordinated actions of these multifaceted regulations determine cell development, cell cycle regulation, cell state and fate, and the ultimate responses in health and disease. Therefore, studies of epigenetic modulations are critical for our understanding of gene regulation mechanisms at the molecular, cellular, tissue, and organ levels. The aim of this review is to provide biomedical engineers with an overview of the principles of epigenetics, methods of study, recent findings in epigenetic regulation in health and disease, and computational and sequencing tools for epigenetics analysis, with an emphasis on the cardiovascular system. This review concludes with the perspectives of the application of bioengineering to advance epigenetics and the utilization of epigenetics to translate bioengineering research into clinical medicine.

Maximum proton kinetic energy and patient-generated neutron fluence considerations in proton beam arc delivery radiation therapy.

PubMed

Sengbusch, E; Pérez-Andújar, A; DeLuca, P M; Mackie, T R

2009-02-01

Several compact proton accelerator systems for use in proton therapy have recently been proposed. Of paramount importance to the development of such an accelerator system is the maximum kinetic energy of protons, immediately prior to entry into the patient, that must be reached by the treatment system. The commonly used value for the maximum kinetic energy required for a medical proton accelerator is 250 MeV, but it has not been demonstrated that this energy is indeed necessary to treat all or most patients eligible for proton therapy. This article quantifies the maximum kinetic energy of protons, immediately prior to entry into the patient, necessary to treat a given percentage of patients with rotational proton therapy, and examines the impact of this energy threshold on the cost and feasibility of a compact, gantry-mounted proton accelerator treatment system. One hundred randomized treatment plans from patients treated with IMRT were analyzed. The maximum radiological pathlength from the surface of the patient to the distal edge of the treatment volume was obtained for 180 degrees continuous arc proton therapy and for 180 degrees split arc proton therapy (two 90 degrees arcs) using CT# profiles from the Pinnacle (Philips Medical Systems, Madison, WI) treatment planning system. In each case, the maximum kinetic energy of protons, immediately prior to entry into the patient, that would be necessary to treat the patient was calculated using proton range tables for various media. In addition, Monte Carlo simulations were performed to quantify neutron production in a water phantom representing a patient as a function of the maximum proton kinetic energy achievable by a proton treatment system. Protons with a kinetic energy of 240 MeV, immediately prior to entry into the patient, were needed to treat 100% of patients in this study. However, it was shown that 90% of patients could be treated at 198 MeV, and 95% of patients could be treated at 207 MeV. Decreasing the proton kinetic energy from 250 to 200 MeV decreases the total neutron energy fluence produced by stopping a monoenergetic pencil beam in a water phantom by a factor of 2.3. It is possible to significantly lower the requirements on the maximum kinetic energy of a compact proton accelerator if the ability to treat a small percentage of patients with rotational therapy is sacrificed. This decrease in maximum kinetic energy, along with the corresponding decrease in neutron production, could lower the cost and ease the engineering constraints on a compact proton accelerator treatment facility.

Frontiers in Industrial Arts Education.

ERIC Educational Resources Information Center

MacDonnell, Elisabeth, Ed.; Strosnider, Floy, Ed.

Presentation topics of the 28th annual American Industrial Arts Association Convention include: (1) "Where We Are in Federal Legislation Programs," (2) "Frontiers in Industrial Arts Education," and (3) "Industry's Cooperation with Education." Eleven symposia were conducted on the topic of "Implementing Frontier Ideas in Industrial Arts Education…

Probing the proton channels in subunit N of Complex I from Escherichia coli through intra-subunit cross-linking.

PubMed

Tursun, Ablat; Zhu, Shaotong; Vik, Steven B

2016-12-01

Respiratory Complex I appears to have 4 sites for proton translocation, which are coupled to the oxidation of NADH and reduction of coenzyme Q. The proton pathways are thought to be made of offset half-channels that connect to the membrane surfaces, and are connected by a horizontal path through the center of the membrane. In this study of the enzyme from Escherichia coli, subunit N, containing one of the sites, was targeted. Pairs of cysteine residues were introduced into neighboring α-helices along the proposed proton pathways. In an effort to constrain conformational changes that might occur during proton translocation, we attempted to form disulfide bonds or methanethiosulfonate bridges between two engineered cysteine residues. Cysteine modification was inferred by the inability of PEG-maleimide to shift the electrophoretic mobility of subunit N, which will occur upon reaction with free sulfhydryl groups. After the cross-linking treatment, NADH oxidase and NADH-driven proton translocation were measured. Ten different pairs of cysteine residues showed evidence of cross-linking. The most significant loss of enzyme activity was seen for residues near the essential Lys 395. This residue is positioned between the proposed proton half-channel to the periplasm and the horizontal connection through subunit N, and is also near the essential Glu 144 of subunit M. The results suggest important conformational changes in this region for the delivery of protons to the periplasm, or for coupling the actions of subunit N to subunit M. Copyright © 2016 Elsevier B.V. All rights reserved.

40 CFR 81.24 - Niagara Frontier Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.24 Niagara Frontier Intrastate Air Quality Control Region. The Niagara Frontier Intrastate Air Quality Control Region (New York) consists of the territorial area...

40 CFR 81.24 - Niagara Frontier Intrastate Air Quality Control Region.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.24 Niagara Frontier Intrastate Air Quality Control Region. The Niagara Frontier Intrastate Air Quality Control Region (New York) consists of the territorial area...

40 CFR 81.24 - Niagara Frontier Intrastate Air Quality Control Region.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.24 Niagara Frontier Intrastate Air Quality Control Region. The Niagara Frontier Intrastate Air Quality Control Region (New York) consists of the territorial area...

40 CFR 81.24 - Niagara Frontier Intrastate Air Quality Control Region.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.24 Niagara Frontier Intrastate Air Quality Control Region. The Niagara Frontier Intrastate Air Quality Control Region (New York) consists of the territorial area...

40 CFR 81.24 - Niagara Frontier Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.24 Niagara Frontier Intrastate Air Quality Control Region. The Niagara Frontier Intrastate Air Quality Control Region (New York) consists of the territorial area...

Chandra Radiation Environment Modeling

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Blackwell, W. C.

2003-01-01

CRMFLX (Chandra Radiation Model of ion FluX) is a radiation environment risk mitigation tool for use as a decision aid in planning the operations times for Chandra's Advanced CCD Imaging Spectrometer (ACIS) detector. The accurate prediction of the proton flux environment with energies of 100 - 200 keV is needed in order to protect the ACIS detector against proton degradation. Unfortunately, protons of this energy are abundant in the region of space Chandra must operate, and on-board particle detectors do not measure proton flux levels of the required energy range. This presentation will describe the plasma environment data analysis and modeling basis of the CRMFLX engineering environment model developed to predict the proton flux in the solar wind, magnetosheath, and magnetosphere phenomenological regions of geospace. The recently released CRMFLX Version 2 implementation includes an algorithm that propagates flux from an observation location to other regions of the magnetosphere based on convective ExB and VB-curvature particle drift motions. This technique has the advantage of more completely filling out the database and makes maximum use of limited data obtained during high Kp periods or in areas of the magnetosphere with poor satellite flux measurement coverage.

Nanotechnology in bone tissue engineering.

PubMed

Walmsley, Graham G; McArdle, Adrian; Tevlin, Ruth; Momeni, Arash; Atashroo, David; Hu, Michael S; Feroze, Abdullah H; Wong, Victor W; Lorenz, Peter H; Longaker, Michael T; Wan, Derrick C

2015-07-01

Nanotechnology represents a major frontier with potential to significantly advance the field of bone tissue engineering. Current limitations in regenerative strategies include impaired cellular proliferation and differentiation, insufficient mechanical strength of scaffolds, and inadequate production of extrinsic factors necessary for efficient osteogenesis. Here we review several major areas of research in nanotechnology with potential implications in bone regeneration: 1) nanoparticle-based methods for delivery of bioactive molecules, growth factors, and genetic material, 2) nanoparticle-mediated cell labeling and targeting, and 3) nano-based scaffold construction and modification to enhance physicochemical interactions, biocompatibility, mechanical stability, and cellular attachment/survival. As these technologies continue to evolve, ultimate translation to the clinical environment may allow for improved therapeutic outcomes in patients with large bone deficits and osteodegenerative diseases. Traditionally, the reconstruction of bony defects has relied on the use of bone grafts. With advances in nanotechnology, there has been significant development of synthetic biomaterials. In this article, the authors provided a comprehensive review on current research in nanoparticle-based therapies for bone tissue engineering, which should be useful reading for clinicians as well as researchers in this field. Copyright © 2015 Elsevier Inc. All rights reserved.

Experimental and computational studies on creatininium 4-nitrobenzoate - An organic proton transfer complex

NASA Astrophysics Data System (ADS)

Thirumurugan, R.; Anitha, K.

2017-10-01

A new organic proton transfer complex of creatininium 4-nitrobenzoate (C4NB) has been synthesized and its single crystals were grown successfully by slow evaporation technique. The grown single crystal was subjected to various characterization techniques like single crystal X-ray diffraction (SCXRD), FTIR, FT-Raman and Kurtz-Perry powder second harmonic generation (SHG). The SCXRD analysis revealed that C4NB was crystallized into orthorhombic crystal system, with noncentrosymmetric (NCS), P212121 space group. The creatininium cation and 4-nitrobenzoate anion were connected through a pair of N__H⋯O hydrogen bonds (N(3)__H(6) ⋯ O(3) (x+1, y, z) and N(2)__H(5) &ctdot O(2) (x-1/2, -y-1/2, -z+2)) and fashioned a R22(8) ring motif. The crystal structure was stabilized by strong N__H⋯O and weak C__H⋯O intermolecular interactions and it was quantitatively analysed by Hirshfeld surface and fingerprint (FP) analysis. FTIR and FT-Raman studies confirmed the vibrational modes of functional groups present in C4NB compound indubitably. SHG efficiency of grown crystal was 4.6 times greater than that of standard potassium dihydrogen phosphate (KDP) material. Moreover, density functional theory (DFT) studies such as Mulliken charge distribution, frontier molecular orbitals (FMOs), molecular electrostatic potential (MEP) map, natural bond orbital analysis (NBO) and first order hyperpolarizability (β0) were calculated to explore the structure-property relationship.

Determination of Structures and Energetics of Small- and Medium-Sized One-Carbon-Bridged Twisted Amides using ab Initio Molecular Orbital Methods: Implications for Amidic Resonance along the C-N Rotational Pathway.

PubMed

Szostak, Roman; Aubé, Jeffrey; Szostak, Michal

2015-08-21

Twisted amides containing nitrogen at the bridgehead position are attractive practical prototypes for the investigation of the electronic and structural properties of nonplanar amide linkages. Changes that occur during rotation around the N-C(O) axis in one-carbon-bridged twisted amides have been studied using ab initio molecular orbital methods. Calculations at the MP2/6-311++G(d,p) level performed on a set of one-carbon-bridged lactams, including 20 distinct scaffolds ranging from [2.2.1] to [6.3.1] ring systems, with the C═O bond on the shortest bridge indicate significant variations in structures, resonance energies, proton affinities, core ionization energies, frontier molecular orbitals, atomic charges, and infrared frequencies that reflect structural changes corresponding to the extent of resonance stabilization during rotation along the N-C(O) axis. The results are discussed in the context of resonance theory and activation of amides toward N-protonation (N-activation) by distortion. This study demonstrates that one-carbon-bridged lactams-a class of readily available, hydrolytically robust twisted amides-are ideally suited to span the whole spectrum of the amide bond distortion energy surface. Notably, this study provides a blueprint for the rational design and application of nonplanar amides in organic synthesis. The presented findings strongly support the classical amide bond resonance model in predicting the properties of nonplanar amides.

Light-energy conversion in engineered microorganisms.

PubMed

Johnson, Ethan T; Schmidt-Dannert, Claudia

2008-12-01

Increasing interest in renewable resources by the energy and chemical industries has spurred new technologies both to capture solar energy and to develop biologically derived chemical feedstocks and fuels. Advances in molecular biology and metabolic engineering have provided new insights and techniques for increasing biomass and biohydrogen production, and recent efforts in synthetic biology have demonstrated that complex regulatory and metabolic networks can be designed and engineered in microorganisms. Here, we explore how light-driven processes may be incorporated into nonphotosynthetic microbes to boost metabolic capacity for the production of industrial and fine chemicals. Progress towards the introduction of light-driven proton pumping or anoxygenic photosynthesis into Escherichia coli to increase the efficiency of metabolically-engineered biosynthetic pathways is highlighted.

jsc2013e048273

NASA Image and Video Library

2013-05-22

Behind the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, the Expedition 36/37 backup and prime crewmembers pose for pictures in front of a Proton rocket statue May 22 following traditional ceremonies. From left to right are backup Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, backup Soyuz Commander Mikhail Tyurin, backup Flight Engineer Rick Mastracchio of NASA, prime Flight Engineer Karen Nyberg of NASA, prime Soyuz Commander Fyodor Yurchikhin and prime Flight Engineer Luca Parmitano of the European Space Agency. Nyberg, Yurchikhin and Parmitano are preparing for their launch May 29, Kazakh time, in the Soyuz TMA-09M spacecraft to begin a 5 ½ month mission on the International Space Station. NASA/Victor Zelentsov

Cape York Peninsula, Australia: A Frontier Region Undergoing a Multifunctional Transition with Indigenous Engagement

ERIC Educational Resources Information Center

Holmes, John

2012-01-01

Within Australia's tropical savanna zone, the northernmost frontier regions have experienced the swiftest transition towards multifunctional occupance, as a formerly flimsy productivist mode is readily displaced by more complex modes, with greater prominence given to consumption, protection and Indigenous values. Of these frontier regions, Cape…

Frontiers in Distributed Optimization and Control of Sustainable Power

Science.gov Websites

Optimization and Control of Sustainable Power Systems Workshop Frontiers in Distributed Optimization and Control of Sustainable Power Systems Workshop In January 2016, NREL's energy systems integration team hosted a workshop on frontiers in distributed optimization and control of sustainable power systems. The

Organising Industrial Knowledge Dissemination on Frontier Technology

ERIC Educational Resources Information Center

Brintrup, A. M.; Ranasinghe, D.

2008-01-01

This paper describes the challenges faced by frontier technology education, typical among large integrated EU projects. These include an evolving nature, the scarcity of experts and established material, and the need for relevant material. Classical approaches to learning seem to not adequately address the needs of frontier technology alone.…

On the Endogeneity of the Mean-Variance Efficient Frontier.

ERIC Educational Resources Information Center

Somerville, R. A.; O'Connell, Paul G. J.

2002-01-01

Explains that the endogeneity of the efficient frontier in the mean-variance model of portfolio selection is commonly obscured in portfolio selection literature and in widely used textbooks. Demonstrates endogeneity and discusses the impact of parameter changes on the mean-variance efficient frontier and on the beta coefficients of individual…

American Pathfinders: Using Ray Bradbury's "Martian Chronicles" To Teach Frontier History.

ERIC Educational Resources Information Center

Schmalholz, Deborah Wielgot

1999-01-01

Presents an interdisciplinary thematic unit designed for eleventh graders that uses selected chapters of "The Martian Chronicles" to teach frontier history. Maintains that Bradbury's novel enriches students' understanding of the frontier because it compares the interactions between Native inhabitants of Mars and Earthlings to the…

Expanding the Frontiers of Population Nutrition Research: New Questions, New Methods, and New Approaches12

PubMed Central

Pelletier, David L.; Porter, Christine M.; Aarons, Gregory A.; Wuehler, Sara E.; Neufeld, Lynnette M.

2013-01-01

Nutrition research, ranging from molecular to population levels and all points along this spectrum, is exploring new frontiers as new technologies and societal changes create new possibilities and demands. This paper defines a set of frontiers at the population level that are being created by the increased societal recognition of the importance of nutrition; its connection to urgent health, social, and environmental problems; and the need for effective and sustainable solutions at the population level. The frontiers are defined in terms of why, what, who, and how we study at the population level and the disciplinary foundations for that research. The paper provides illustrations of research along some of these frontiers, an overarching framework for population nutrition research, and access to some of the literature from outside of nutrition that can enhance the intellectual coherence, practical utility, and societal benefit of population nutrition research. The frontiers defined in this paper build on earlier forward-looking efforts by the American Society for Nutrition and extend these efforts in significant ways. The American Society for Nutrition and its members can play pivotal roles in advancing these frontiers by addressing a number of well-recognized challenges associated with transdisciplinary and engaged research. PMID:23319128

Genome-Guided Analysis of Clostridium ultunense and Comparative Genomics Reveal Different Strategies for Acetate Oxidation and Energy Conservation in Syntrophic Acetate-Oxidising Bacteria

PubMed Central

Manzoor, Shahid; Schnürer, Anna; Müller, Bettina

2018-01-01

Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAOB) that are found in engineered biogas processes operating with high ammonia concentrations. It has been proven to oxidise acetate in cooperation with hydrogenotrophic methanogens. There is evidence that the Wood-Ljungdahl (WL) pathway plays an important role in acetate oxidation. In this study, we analysed the physiological and metabolic capacities of C. ultunense strain Esp and strain BST on genome scale and conducted a comparative study of all the known characterised SAOB, namely Syntrophaceticus schinkii, Thermacetogenium phaeum, Tepidanaerobacter acetatoxydans, and Pseudothermotoga lettingae. The results clearly indicated physiological robustness to be beneficial for anaerobic digestion environments and revealed unexpected metabolic diversity with respect to acetate oxidation and energy conservation systems. Unlike S. schinkii and Th. phaeum, C. ultunense clearly does not employ the oxidative WL pathway for acetate oxidation, as its genome (and that of P. lettingae) lack important key genes. In both of those species, a proton motive force is likely formed by chemical protons involving putative electron-bifurcating [Fe-Fe] hydrogenases rather than proton pumps. No genes encoding a respiratory Ech (energy-converting hydrogenase), as involved in energy conservation in Th. phaeum and S. schinkii, were identified in C. ultunense and P. lettingae. Moreover, two respiratory complexes sharing similarities to the proton-translocating ferredoxin:NAD+ oxidoreductase (Rnf) and the Na+ pumping NADH:quinone hydrogenase (NQR) were predicted. These might form a respiratory chain that is involved in the reduction of electron acceptors rather than protons. However, involvement of these complexes in acetate oxidation in C. ultunense and P. lettingae needs further study. This genome-based comparison provides a solid platform for future meta-proteomics and meta-transcriptomics studies and for metabolic engineering, control, and monitoring of SAOB. PMID:29690652

Genome-Guided Analysis of Clostridium ultunense and Comparative Genomics Reveal Different Strategies for Acetate Oxidation and Energy Conservation in Syntrophic Acetate-Oxidising Bacteria.

PubMed

Manzoor, Shahid; Schnürer, Anna; Bongcam-Rudloff, Erik; Müller, Bettina

2018-04-23

Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAOB) that are found in engineered biogas processes operating with high ammonia concentrations. It has been proven to oxidise acetate in cooperation with hydrogenotrophic methanogens. There is evidence that the Wood-Ljungdahl (WL) pathway plays an important role in acetate oxidation. In this study, we analysed the physiological and metabolic capacities of C. ultunense strain Esp and strain BS T on genome scale and conducted a comparative study of all the known characterised SAOB, namely Syntrophaceticus schinkii , Thermacetogenium phaeum , Tepidanaerobacter acetatoxydans , and Pseudothermotoga lettingae . The results clearly indicated physiological robustness to be beneficial for anaerobic digestion environments and revealed unexpected metabolic diversity with respect to acetate oxidation and energy conservation systems. Unlike S. schinkii and Th. phaeum , C. ultunense clearly does not employ the oxidative WL pathway for acetate oxidation, as its genome (and that of P. lettingae ) lack important key genes. In both of those species, a proton motive force is likely formed by chemical protons involving putative electron-bifurcating [Fe-Fe] hydrogenases rather than proton pumps. No genes encoding a respiratory Ech (energy-converting hydrogenase), as involved in energy conservation in Th. phaeum and S. schinkii, were identified in C. ultunense and P. lettingae . Moreover, two respiratory complexes sharing similarities to the proton-translocating ferredoxin:NAD⁺ oxidoreductase (Rnf) and the Na⁺ pumping NADH:quinone hydrogenase (NQR) were predicted. These might form a respiratory chain that is involved in the reduction of electron acceptors rather than protons. However, involvement of these complexes in acetate oxidation in C. ultunense and P. lettingae needs further study. This genome-based comparison provides a solid platform for future meta-proteomics and meta-transcriptomics studies and for metabolic engineering, control, and monitoring of SAOB.

Quantum nature of protons in water probed by scanning tunneling microscopy and spectroscopy

NASA Astrophysics Data System (ADS)

Guo, Jing; Lü, Jing-Tao; Feng, Yexin; Chen, Ji; Peng, Jinbo; Lin, Zeren; Meng, Xiangzhi; Wang, Zhichang; Li, Xin-Zheng; Wang, En-Ge; Jiang, Ying; Jing-Tao Lü Team; Xin-Zheng Li Team

The complexity of hydrogen-bonding interaction largely arises from the quantum nature of light hydrogen nuclei, which has remained elusive for decades. Here we report the direct assessment of nuclear quantum effects on the strength of a single hydrogen bond formed at a water-salt interface, using tip-enhanced inelastic electron tunneling spectroscopy (IETS) based on a low-temperature scanning tunneling microscope (STM). The IETS signals are resonantly enhanced by gating the frontier orbitals of water via a chlorine-terminated STM tip, such that the hydrogen-bonding strength can be determined with unprecedentedly high accuracy from the redshift in the O-H stretching frequency of water. Isotopic substitution experiments combined with quantum simulations reveal that the anharmonic quantum fluctuations of hydrogen nuclei weaken the weak hydrogen bonds and strengthen the relatively strong ones. However, this trend can be completely reversed when the hydrogen bond is strongly coupled to the polar atomic sites of the surface.

Fluorescence and physical properties of the organic salt 2-chloro-4-nitrobenzoate-3-ammonium-phenol

NASA Astrophysics Data System (ADS)

Mani, Rajaboopathi; Rietveld, Ivo B.; Nicolaï, Béatrice; Varadharajan, Krishnakumar; Louhi-Kultanen, Marjatta; Narasimhan, Surumbarkuzhali

2015-09-01

Organic salt 2-chloro-4-nitrobenzoate (CNBA-) 3-ammonium-phenol (AP+) exhibits fluorescence at 338 nm in solution and frontier molecular orbitals generated from TDDFT calculations indicate that the ground state and the excited state are physically separated on AP+ and CNBA-. The crystal structure and physical-chemical properties of the CNBA- · AP+ were investigated using X-ray single crystal and powder diffraction, SEM, FTIR, UV-Vis-NIR, and fluorescence spectrometry. X-ray diffraction demonstrates that the two molecules are linked via N+-H⋯O- ammonium-carboxylate interactions, as expected considering their interaction propensities. Proton transfer has been confirmed by FTIR analysis. The melting point of CNBA- · AP+ was observed at 186 °C, which is higher than pure CNBA (140 °C) or AP (120 °C). The observation of a spatially separated HOMO and LUMO possessing a narrow ΔEST = 73.3 meV and an emission in the blue region is promising as an alternative method for the production of OLED materials.

Structural and spectroscopic investigation of glycinium oxalurate

NASA Astrophysics Data System (ADS)

Kavitha, T.; Pasupathi, G.; Marchewka, M. K.; Anbalagan, G.; Kanagathara, N.

2017-09-01

Glycinium oxalurate (GO) single crystals has been synthesized and grown by the slow solvent evaporation method at room temperature. Single crystal X-ray diffraction study confirms that GO crystal crystallizes in the monoclinic system with centrosymmetric space group P121/c1. The grown crystals are built up from single protonated glycinium residues and single dissociated oxalurate anions. A combination of ionic and donor-acceptor hydrogen-bond interactions linking together the glycine and oxaluric acid residues forms a three-dimensional network. Hydrogen bonded network present in the crystal gives notable vibrational effect. The molecular geometry, vibrational frequencies and intensity of the vibrational bands have been interpreted with the aid of structure optimization based on HF and density functional theory B3LYP methods with 6-311++G(d,p) basis set. Frontier molecular orbital energies and other related electronic properties are calculated. The natural bonding orbital (NBO) charges have been calculated and interpreted. The molecular electrostatic potential map has been constructed and discussed in detail.

Stem cells’ guided gene therapy of cancer: New frontier in personalized and targeted therapy

PubMed Central

Mavroudi, Maria; Zarogoulidis, Paul; Porpodis, Konstantinos; Kioumis, Ioannis; Lampaki, Sofia; Yarmus, Lonny; Malecki, Raf; Zarogoulidis, Konstantinos; Malecki, Marek

2014-01-01

Introduction Diagnosis and therapy of cancer remain to be the greatest challenges for all physicians working in clinical oncology and molecular medicine. The statistics speak for themselves with the grim reports of 1,638,910 men and women diagnosed with cancer and nearly 577,190 patients passed away due to cancer in the USA in 2012. For practicing clinicians, who treat patients suffering from advanced cancers with contemporary systemic therapies, the main challenge is to attain therapeutic efficacy, while minimizing side effects. Unfortunately, all contemporary systemic therapies cause side effects. In treated patients, these side effects may range from nausea to damaged tissues. In cancer survivors, the iatrogenic outcomes of systemic therapies may include genomic mutations and their consequences. Therefore, there is an urgent need for personalized and targeted therapies. Recently, we reviewed the current status of suicide gene therapy for cancer. Herein, we discuss the novel strategy: genetically engineered stem cells’ guided gene therapy. Review of therapeutic strategies in preclinical and clinical trials Stem cells have the unique potential for self renewal and differentiation. This potential is the primary reason for introducing them into medicine to regenerate injured or degenerated organs, as well as to rejuvenate aging tissues. Recent advances in genetic engineering and stem cell research have created the foundations for genetic engineering of stem cells as the vectors for delivery of therapeutic transgenes. Specifically in oncology, the stem cells are genetically engineered to deliver the cell suicide inducing genes selectively to the cancer cells only. Expression of the transgenes kills the cancer cells, while leaving healthy cells unaffected. Herein, we present various strategies to bioengineer suicide inducing genes and stem cell vectors. Moreover, we review results of the main preclinical studies and clinical trials. However, the main risk for therapeutic use of stem cells is their cancerous transformation. Therefore, we discuss various strategies to safeguard stem cell guided gene therapy against iatrogenic cancerogenesis. Perspectives Defining cancer biomarkers to facilitate early diagnosis, elucidating cancer genomics and proteomics with modern tools of next generation sequencing, and analyzing patients’ gene expression profiles provide essential data to elucidate molecular dynamics of cancer and to consider them for crafting pharmacogenomics-based personalized therapies. Streamlining of these data into genetic engineering of stem cells facilitates their use as the vectors delivering therapeutic genes into specific cancer cells. In this realm, stem cells guided gene therapy becomes a promising new frontier in personalized and targeted therapy of cancer. PMID:24860662

Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)

PubMed Central

Pizzio, Gaston A.; Hirschi, Kendal D.; Gaxiola, Roberto A.

2017-01-01

Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H+-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H+-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity. PMID:28955362

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Langli; Su, Mao; Yan, Pengfei

The presence of water vapor, intentional or unavoidable, is crucial to many materials applications, such as steam generator, turbine engine, fuel cell, catalyst, and corrosion 1-6. Phenomenologically, water vapor has been noticed to accelerate oxidation of metals/alloys 7,8, however, the atomistic mechanisms remain elusive. Herein, through direct in situ atomic-scale transmission electron microscopy observation and density functional theory calculation, we reveal that water vapor enhanced oxidation of Ni-Cr alloy is associated with proton dissolution promoted vacancy formation, migration and clustering. Protons derived from water dissociation occupy interstitial position in the oxide lattice, which consequently leads to the lowering of bothmore » vacancy formation energy and the cation diffusion barrier. The atomic scale observations reveal a water vapor derived proton mediated oxide growth mechanism, which provides insights for reckoning many technological processes concerning materials in moist environment at elevated temperatures.« less

Optimum angle-cut of collimator for dense objects in high-energy proton radiography

NASA Astrophysics Data System (ADS)

Xu, Hai-Bo; Zheng, Na

2016-02-01

The use of minus identity lenses with an angle-cut collimator can achieve high contrast images in high-energy proton radiography. This article presents the principles of choosing the angle-cut aperture of the collimator for different energies and objects. Numerical simulation using the Monte Carlo code Geant4 has been implemented to investigate the entire radiography for the French test object. The optimum angle-cut apertures of the collimators are also obtained for different energies. Supported by NSAF (11176001) and Science and Technology Developing Foundation of China Academy of Engineering Physics (2012A0202006)

Progress towards next generation hadron colliders: FCC-hh, HE-LHC, and SPPC

NASA Astrophysics Data System (ADS)

Zimmermann, Frank; EuCARD-2 Extreme Beams Collaboration; Future Circular Collider (FCC) Study Collaboration

2017-01-01

A higher-energy circular proton collider is generally considered to be the only path available in this century for exploring energy scales well beyond the reach of the Large Hadron Collider (LHC) presently in operation at CERN. In response to the 2013 Update of the European Strategy for Particle Physics and aligned with the 2014 US ``P5'' recommendations, the international Future Circular Collider (FCC) study, hosted by CERN, is designing such future frontier hadron collider. This so-called FCC-hh will provide proton-proton collisions at a centre-of-mass energy of 100 TeV, with unprecedented luminosity. The FCC-hh energy goal is reached by combining higher-field, 16 T magnets, based on Nb3Sn superconductor, and a new 100 km tunnel connected to the LHC complex. In addition to the FCC-hh proper, the FCC study is also exploring the possibility of a High-Energy LHC (HE-LHC), with a centre-of-mass energy of 25-27 TeV, as could be achieved in the existing 27 km LHC tunnel using the FCC-hh magnet technology. A separate design effort centred at IHEP Beijing aims at developing and constructing a similar collider in China, with a smaller circumference of about 54 km, called SPPC. Assuming even higher-field 20 T magnets, by relying on high-temperature superconductor, the SPPC could reach a c.m. energy of about 70 TeV. This presentation will report the motivation and the present status of the R&D for future hadron colliders, a comparison of the three designs under consideration, the major challenges, R&D topics, the international technology programs, and the emerging global collaboration. Work supported by the European Commission under Capacities 7th Framework Programme project EuCARD-2, Grant Agreement 312453, and the HORIZON 2020 project EuroCirCol, Grant Agreement 654305.

Kinetic Analysis of Competitive Electrocatalytic Pathways: New Insights into Hydrogen Production with Nickel Electrocatalysts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiedner, Eric S.; Brown, Houston J.; Helm, Monte L.

2016-01-20

The hydrogen production electrocatalyst Ni(PPh2NPh2)22+ (1) is capable of traversing multiple electrocatalytic pathways. When using dimethylformamidium, DMF(H)+, the mechanism of formation of H2 catalyzed by 1 changes from an ECEC to an EECC mechanism as the potential approaches the Ni(I/0) couple. Two recent electrochemical methods, current-potential analysis and foot-of-the-wave analysis (FOWA), were performed on 1 to measure the detailed chemical kinetics of the competing ECEC and EECC pathways. A sensitivity analysis was performed on the electrochemical methods using digital simulations to gain a better understanding of their strengths and limitations. Notably, chemical rate constants were significantly underestimated when not accountingmore » for electron transfer kinetics, even when electron transfer was fast enough to afford a reversible non-catalytic wave. The EECC pathway of 1 was found to be faster than the ECEC pathway under all conditions studied. Using buffered DMF: DMF(H)+ mixtures led to an increase in the catalytic rate constant (kobs) of the EECC pathway, but kobs for the ECEC pathway did not change when using buffered acid. Further kinetic analysis of the ECEC path revealed that added base increases the rate of isomerization of the exo-protonated Ni(0) isomers to the catalytically active endo-isomers, but decreases the net rate of protonation of Ni(I). FOWA on 1 did not provide accurate rate constants due to incomplete reduction of the exo-protonated Ni(I) intermediate at the foot of the wave, but FOWA could be used to estimate the reduction potential of this previously undetected intermediate. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

Heart of the Solution - Energy Frontiers (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Green, Peter F. (Director, Center for Solar and Thermal Energy Conversion, University of Michigan); CSTEC Staff

2017-12-09

'Heart of the Solution - Energy Frontiers' was submitted by the Center for Solar and Thermal Energy Conversion (CSTEC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. This video was both the People's Choice Award winner and selected as one of five winners by a distinguished panel of judges for its 'exemplary explanation of the role of an Energy Frontier Research Center'. The Center for Solar and Thermal Energy Conversion is directed by Peter F. Green at the University of Michigan. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Solar and Thermal Energy Conversion is 'to study complex material structures on the nanoscale to identify key features for their potential use as materials to convert solar energy and heat to electricity.' Research topics are: solar photovoltaic, photonic, optics, solar thermal, thermoelectric, phonons, thermal conductivity, solar electrodes, defects, ultrafast physics, interfacial characterization, matter by design, novel materials synthesis, charge transport, and self-assembly.

"Nano": the new nemesis of cancer.

PubMed

Hede, Shantesh; Huilgol, Nagraj

2006-01-01

Materials at nano dimensions exhibit totally different properties compared to their bulk and atomic states. This feature has been harnessed by scientists from various disciplines, to develop functional nanomaterials for cancer diagnosis and therapeutics. The success stories range from delivering chemotherapeutic molecules in nano-sized formulations to functional nanomaterials, which deliver thermal and radiotherapy at specific targeted sites. This brief review summarizes the recent developments of various nanotechnologies in cancer therapy and diagnostics, both from the research sector and the upcoming products in pipeline on its route to commercialization. Supportive engineering innovations and frontiers in nanomolecular research, with a potential to revolutionize cancer therapy, have been discussed in brief.

The role of mechanics in biological and bio-inspired systems.

PubMed

Egan, Paul; Sinko, Robert; LeDuc, Philip R; Keten, Sinan

2015-07-06

Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many natural systems that achieve advanced properties, such as high strength-to-weight ratios and stimuli-responsive adaptability. Discovering how and why biological systems attain these desirable mechanical functionalities often reveals principles that inform new synthetic designs based on biological systems. Such approaches have traditionally found success in medical applications, and are now informing breakthroughs in diverse frontiers of science and engineering.

Nucleic acid aptamers: an emerging frontier in cancer therapy.

PubMed

Zhu, Guizhi; Ye, Mao; Donovan, Michael J; Song, Erqun; Zhao, Zilong; Tan, Weihong

2012-11-04

The last two decades have witnessed the development and application of nucleic acid aptamers in a variety of fields, including target analysis, disease therapy, and molecular and cellular engineering. The efficient and widely applicable aptamer selection, reproducible chemical synthesis and modification, generally impressive target binding selectivity and affinity, relatively rapid tissue penetration, low immunogenicity, and rapid systemic clearance make aptamers ideal recognition elements for use as therapeutics or for in vivo delivery of therapeutics. In this feature article, we discuss the development and biomedical application of nucleic acid aptamers, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.

Frontier Schools in Montana: Challenges and Sustainability Practices. A Research Report

ERIC Educational Resources Information Center

Harmon, Hobart L.; Morton, Claudette

2010-01-01

This study reveals the challenges confronting small, rural "frontier" schools in Montana and the practices that contribute to their sustainability. A Montana frontier school is defined as a school district with 200 or fewer students and its attendant community in a county with five or fewer people per square mile. The researcher…

Fermilab | Science at Fermilab | Experiments & Projects | Energy Frontier

Science.gov Websites

Go Science at Fermilab Fermilab and the Higgs Boson Frontiers of Particle Physics Experiments & Answers Submit a Question Frontiers of Particle Physics Benefits to Society Benefits to Society Medicine Inquiring Minds Questions About Physics Other High-Energy Physics Sites More About Particle Physics Library

Efficient Provision of Employment Service Outputs: A Production Frontier Analysis.

ERIC Educational Resources Information Center

Cavin, Edward S.; Stafford, Frank P.

1985-01-01

This article develops a production frontier model for the Employment Service and assesses the relative efficiency of the 51 State Employment Security Agencies in attaining program outcomes close to that frontier. This approach stands in contrast to such established practices as comparing programs to their own previous performance. (Author/CT)

Center for Support of Mental Health Services in Isolated Rural Areas. Final Report.

ERIC Educational Resources Information Center

Ciarlo, James A.

In 1994, the University of Denver received a grant to develop and operate the Frontier Mental Health Services Resource Network (FMHSRN). FMHSRN's principal aim was to improve delivery of mental health services in sparsely populated "frontier" areas by providing technical assistance to frontier and rural audiences. Traditional…

Dairy farm cost efficiency.

PubMed

Tauer, L W; Mishra, A K

2006-12-01

A stochastic cost equation was estimated for US dairy farms using national data from the production year 2000 to determine how farmers might reduce their cost of production. Cost of producing a unit of milk was estimated into separate frontier (efficient) and inefficiency components, with both components estimated as a function of management and causation variables. Variables were entered as impacting the frontier component as well as the efficiency component of the stochastic curve because a priori both components could be impacted. A factor that has an impact on the cost frontier was the number of hours per day the milking facility is used. Using the milking facility for more hours per day decreased frontier costs; however, inefficiency increased with increased hours of milking facility use. Thus, farmers can decrease costs with increased utilization of the milking facility, but only if they are efficient in this strategy. Parlors compared with stanchions used for milking did not decrease frontier costs, but decreased costs because of increased efficiency, as did the use of a nutritionist. Use of rotational grazing decreased frontier costs but also increased inefficiency. Older farmers were less efficient.

Space Environment Information System (SPENVIS)

NASA Astrophysics Data System (ADS)

Kruglanski, M.; Messios, N.; de Donder, E.; Gamby, E.; Calders, S.; Hetey, L.; Evans, H.

2009-04-01

SPENVIS is an ESA operational software developed and maintained at BIRA-IASB since 1996. It provides standardized access to most of the recent models of the hazardous space environment, through a user-friendly Web interface (http://www.spenvis.oma.be/). The system allows spacecraft engineers to perform a rapid analysis of environmental problems related to natural radiation belts, solar energetic particles, cosmic rays, plasmas, gases, magnetic fields and micro-particles. Various reporting and graphical utilities and extensive help facilities are included to allow engineers with relatively little familiarity to produce reliable results. SPENVIS also contains an active, integrated version of the ECSS Space Environment Standard and access to in-flight data on the space environment. Although SPENVIS in the first place is designed to help spacecraft engineers, it is also used by technical universities in their educational programs. At present more than 4000 users are registered. With SPENVIS, one can generate a spacecraft trajectory or a coordinate grid and then calculate: geomagnetic coordinates; trapped proton and electron fluxes; solar proton fluences; cosmic ray fluxes; radiation doses (ionising and non-ionising) for simple geometries; a sectoring analysis for dose calculations in more complex geometries; damage equivalent fluences for Si, GaAs and multi-junction solar cells; Geant4 Monte Carlo analysis for doses and pulse height rates in planar and spherical shields; ion LET and flux spectra and single event upset rates; trapped proton flux anisotropy; atmospheric and ionospheric densities and temperatures; atomic oxygen erosion depths; surface and internal charging characteristics; solar array current collections and power losses; wall damage. The new version of SPENVIS (to be released in January 2009) also allows mission analysis for Mars and Jupiter.

Frontier Fields: Engaging Educators, the Youth, and the Public in Exploring the Cosmic Frontier

NASA Astrophysics Data System (ADS)

Lawton, Brandon L.; Eisenhamer, Bonnie; Smith, Denise A.; Summers, Frank; Darnell, John A.; Ryer, Holly

2015-01-01

The Frontier Fields is a multi-cycle program of six deep-field observations of strong-lensing galaxy clusters that will be taken in parallel with six deep 'blank fields.' The three-year long collaborative program is led by observations from NASA's Great Observatories. The observations allow astronomers to look deeper into the universe than ever before, and potentially uncover galaxies that are as much as 100 times fainter than what the telescopes can typically observe. The Frontier Fields science program is ideal for informing audiences about scientific advances and topics in STEM. The study of galaxy properties, statistics, optics, and Einstein's theory of general relativity naturally leverages off of the science returns of the Frontier Fields program. As a result, the Space Telescope Science Institute's Office of Public Outreach (OPO) has initiated an education and public outreach (EPO) project to follow the progress of the Frontier Fields.For over two decades, the Hubble EPO program has sought to bring the wonders of the universe to the education community, the youth, and the public, and engage audiences in the adventure of scientific discovery. Program components include standards-based curriculum-support materials, exhibits and exhibit components, professional development workshops, and direct interactions with scientists. We are also leveraging our new social media strategy to bring the science program to the public in the form of an ongoing blog. The main underpinnings of the program's infrastructure are scientist-educator development teams, partnerships, and an embedded program evaluation component. OPO is leveraging this existing infrastructure to bring the Frontier Fields science program to the education community and the public in a cost-effective way.The Frontier Fields program has just completed its first year. This talk will feature the goals and current status of the Frontier Fields EPO program. We will highlight OPO's strategies and infrastructure that allows for the quick delivery of groundbreaking science to the education community and public.

Proton transfer in microbial electrolysis cells

DOE PAGES

Borole, Abhijeet P.; Lewis, Alex J.

2017-02-15

Proton transfer and electron transfer are of prime importance in the development of microbial electrochemical cells. While electron transfer is primarily controlled by biology, proton transfer is controlled by process engineering and cell design. To develop commercially feasible technologies around the concept of a bioelectrochemical cell, real feedstocks have to be explored and associated limitations have to be identified. Here in this study, the proton transfer rate was quantified for a microbial electrolysis cell (MEC) and its dependence on process parameters was investigated using a proton balance model. The reaction system consisted of a biomass-derived pyrolytic aqueous stream as amore » substrate producing hydrogen in a flow-through MEC. The proton transfer rate increased with anode flow rate and organic loading rate up to a maximum of 0.36 ± 0.01 moles per m 2 per h, equivalent to a hydrogen production rate of 9.08 L per L per day. Higher rates of hydrogen production, reaching 11.7 ± 0.2 L per L per day were achieved, when additional protons were provided via the cathode buffer. Electrochemical impedance spectroscopy shows that proton transfer was the dominant resistance in the production of hydrogen. The quantification of proton transfer rates for MECs with potential for biorefinery application and the demonstration of high hydrogen production rates approaching those required for commercial consideration indicate the strong potential of this technology for renewable hydrogen production. Understanding the transport phenomenon in bioelectrochemical cells is of great significance since these systems have potential for wide-ranging applications including energy production, bioremediation, chemical and nanomaterial synthesis, electro-fermentation, energy storage, desalination, and produced water treatment. Electron transfer in anode biofilms has been investigated extensively, but proton transfer studies are also important, since many cathodic half reactions require protons as the reactant. Determination of transport rates via proton balance was investigated in microbial electrolysis cells, which can be applied to other forms of microbial electrochemical systems. Lastly, these systems have a unique niche in the development of future biorefineries as a means of recovering energy from waste streams with potential for water recycle, making them an integral part of the water–energy nexus focus area.« less

Proton transfer in microbial electrolysis cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borole, Abhijeet P.; Lewis, Alex J.

Proton transfer and electron transfer are of prime importance in the development of microbial electrochemical cells. While electron transfer is primarily controlled by biology, proton transfer is controlled by process engineering and cell design. To develop commercially feasible technologies around the concept of a bioelectrochemical cell, real feedstocks have to be explored and associated limitations have to be identified. Here in this study, the proton transfer rate was quantified for a microbial electrolysis cell (MEC) and its dependence on process parameters was investigated using a proton balance model. The reaction system consisted of a biomass-derived pyrolytic aqueous stream as amore » substrate producing hydrogen in a flow-through MEC. The proton transfer rate increased with anode flow rate and organic loading rate up to a maximum of 0.36 ± 0.01 moles per m 2 per h, equivalent to a hydrogen production rate of 9.08 L per L per day. Higher rates of hydrogen production, reaching 11.7 ± 0.2 L per L per day were achieved, when additional protons were provided via the cathode buffer. Electrochemical impedance spectroscopy shows that proton transfer was the dominant resistance in the production of hydrogen. The quantification of proton transfer rates for MECs with potential for biorefinery application and the demonstration of high hydrogen production rates approaching those required for commercial consideration indicate the strong potential of this technology for renewable hydrogen production. Understanding the transport phenomenon in bioelectrochemical cells is of great significance since these systems have potential for wide-ranging applications including energy production, bioremediation, chemical and nanomaterial synthesis, electro-fermentation, energy storage, desalination, and produced water treatment. Electron transfer in anode biofilms has been investigated extensively, but proton transfer studies are also important, since many cathodic half reactions require protons as the reactant. Determination of transport rates via proton balance was investigated in microbial electrolysis cells, which can be applied to other forms of microbial electrochemical systems. Lastly, these systems have a unique niche in the development of future biorefineries as a means of recovering energy from waste streams with potential for water recycle, making them an integral part of the water–energy nexus focus area.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dykstra, D.; Blomer, J.

Both the CernVM File System (CVMFS) and the Frontier Distributed Database Caching System (Frontier) distribute centrally updated data worldwide for LHC experiments using http proxy caches. Neither system provides privacy or access control on reading the data, but both control access to updates of the data and can guarantee the authenticity and integrity of the data transferred to clients over the internet. CVMFS has since its early days required digital signatures and secure hashes on all distributed data, and recently Frontier has added X.509-based authenticity and integrity checking. In this paper we detail and compare the security models of CVMFSmore » and Frontier.« less

Alternating electron and proton transfer steps in photosynthetic water oxidation

PubMed Central

Klauss, André; Haumann, Michael; Dau, Holger

2012-01-01

Water oxidation by cyanobacteria, algae, and plants is pivotal in oxygenic photosynthesis, the process that powers life on Earth, and is the paradigm for engineering solar fuel–production systems. Each complete reaction cycle of photosynthetic water oxidation requires the removal of four electrons and four protons from the catalytic site, a manganese–calcium complex and its protein environment in photosystem II. In time-resolved photothermal beam deflection experiments, we monitored apparent volume changes of the photosystem II protein associated with charge creation by light-induced electron transfer (contraction) and charge-compensating proton relocation (expansion). Two previously invisible proton removal steps were detected, thereby filling two gaps in the basic reaction-cycle model of photosynthetic water oxidation. In the S2 → S3 transition of the classical S-state cycle, an intermediate is formed by deprotonation clearly before electron transfer to the oxidant (). The rate-determining elementary step (τ, approximately 30 µs at 20 °C) in the long-distance proton relocation toward the protein–water interface is characterized by a high activation energy (Ea = 0.46 ± 0.05 eV) and strong H/D kinetic isotope effect (approximately 6). The characteristics of a proton transfer step during the S0 → S1 transition are similar (τ, approximately 100 µs; Ea = 0.34 ± 0.08 eV; kinetic isotope effect, approximately 3); however, the proton removal from the Mn complex proceeds after electron transfer to . By discovery of the transient formation of two further intermediate states in the reaction cycle of photosynthetic water oxidation, a temporal sequence of strictly alternating removal of electrons and protons from the catalytic site is established. PMID:22988080

Alternating electron and proton transfer steps in photosynthetic water oxidation.

PubMed

Klauss, André; Haumann, Michael; Dau, Holger

2012-10-02

Water oxidation by cyanobacteria, algae, and plants is pivotal in oxygenic photosynthesis, the process that powers life on Earth, and is the paradigm for engineering solar fuel-production systems. Each complete reaction cycle of photosynthetic water oxidation requires the removal of four electrons and four protons from the catalytic site, a manganese-calcium complex and its protein environment in photosystem II. In time-resolved photothermal beam deflection experiments, we monitored apparent volume changes of the photosystem II protein associated with charge creation by light-induced electron transfer (contraction) and charge-compensating proton relocation (expansion). Two previously invisible proton removal steps were detected, thereby filling two gaps in the basic reaction-cycle model of photosynthetic water oxidation. In the S(2) → S(3) transition of the classical S-state cycle, an intermediate is formed by deprotonation clearly before electron transfer to the oxidant (Y Z OX). The rate-determining elementary step (τ, approximately 30 µs at 20 °C) in the long-distance proton relocation toward the protein-water interface is characterized by a high activation energy (E(a) = 0.46 ± 0.05 eV) and strong H/D kinetic isotope effect (approximately 6). The characteristics of a proton transfer step during the S(0) → S(1) transition are similar (τ, approximately 100 µs; E(a) = 0.34 ± 0.08 eV; kinetic isotope effect, approximately 3); however, the proton removal from the Mn complex proceeds after electron transfer to . By discovery of the transient formation of two further intermediate states in the reaction cycle of photosynthetic water oxidation, a temporal sequence of strictly alternating removal of electrons and protons from the catalytic site is established.

Efficiency measurement and uncertainty discussion of an electric engine powered by a ``self-breathing'' and ``self-humidified'' proton exchange membrane fuel cell

NASA Astrophysics Data System (ADS)

Schiavetti, Pierluigi; Del Prete, Zaccaria

2007-08-01

The efficiency of an automotive engine based on a "self-breathing" and "self-humidified" proton exchange membrane fuel cell stack (PEM FC) connected to a dc brushless electrical motor was measured under variable power load conditions. Experiments have been carried out on a small scale 150W engine model. After determining the fuel cell static polarization curve and the time response to power steps, the system was driven to copy on the test bench a "standard urban load cycle" and its instantaneous efficiencies were measured at an acquisition rate of 5Hz. The integral system efficiency over the entire urban load cycle, comprising the losses of the unavoidable auxiliary components of the engine, was then calculated. The fuel cell stack was operated mainly in "partial" dead-end mode, with a periodic anode flow channel purging, and one test was carried out in "pure" dead-end mode, with no anode channel purging. An uncertainty analysis of the efficiencies was carried out, taking into account either type A and type B evaluation methods, strengthening the discussion about the outcomes obtained for a system based on this novel simplified FC type. For our small scale engine we measured over the standard urban cycle, on the basis of the H2 high heating value (HHV), a tank-to-wheel integral efficiency of (18.2±0.8)%, when the fuel cell was operated with periodic flow channel purging, and of (21.5±1.3)% in complete dead-end operation mode.

Efficiency measurement and uncertainty discussion of an electric engine powered by a "self-breathing" and "self-humidified" proton exchange membrane fuel cell.

PubMed

Schiavetti, Pierluigi; Del Prete, Zaccaria

2007-08-01

The efficiency of an automotive engine based on a "self-breathing" and "self-humidified" proton exchange membrane fuel cell stack (PEM FC) connected to a dc brushless electrical motor was measured under variable power load conditions. Experiments have been carried out on a small scale 150 W engine model. After determining the fuel cell static polarization curve and the time response to power steps, the system was driven to copy on the test bench a "standard urban load cycle" and its instantaneous efficiencies were measured at an acquisition rate of 5 Hz. The integral system efficiency over the entire urban load cycle, comprising the losses of the unavoidable auxiliary components of the engine, was then calculated. The fuel cell stack was operated mainly in "partial" dead-end mode, with a periodic anode flow channel purging, and one test was carried out in "pure" dead-end mode, with no anode channel purging. An uncertainty analysis of the efficiencies was carried out, taking into account either type A and type B evaluation methods, strengthening the discussion about the outcomes obtained for a system based on this novel simplified FC type. For our small scale engine we measured over the standard urban cycle, on the basis of the H(2) high heating value (HHV), a tank-to-wheel integral efficiency of (18.2+/-0.8)%, when the fuel cell was operated with periodic flow channel purging, and of (21.5+/-1.3)% in complete dead-end operation mode.

Heart of the Solution - Energy Frontiers (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, Peter F.

"Heart of the Solution- Energy Frontiers" was submitted by the Center for Solar and Thermal Energy Conversion (CSTEC) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. This video was both the People's Choice Award winner and selected as one of five winners by a distinguished panel of judges for its "exemplary explanation of the role of an Energy Frontier Research Center". The Center for Solar and Thermal Energymore » Conversion is directed by Peter F. Green at the University of Michigan. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Solar and Thermal Energy Conversion is 'to study complex material structures on the nanoscale to identify key features for their potential use as materials to convert solar energy and heat to electricity.' Research topics are: solar photovoltaic, photonic, optics, solar thermal, thermoelectric, phonons, thermal conductivity, solar electrodes, defects, ultrafast physics, interfacial characterization, matter by design, novel materials synthesis, charge transport, and self-assembly.« less

The Frontier Framework (and its eight Frontier Archetypes): A new conceptual approach to representing staff and patient well-being in health systems.

PubMed

Baines, Darrin L

2018-05-04

This paper proposes a new conceptual framework for jointly analysing the production of staff and patient welfare in health systems. Research to date has identified a direct link between staff and patient well-being. However, until now, no one has produced a unified framework for analysing them concurrently. In response, this paper introduces the "Frontier Framework". The new conceptual framework is applicable to all health systems regardless of their structure or financing. To demonstrate the benefits of its use, an empirical example of the Frontier Framework is constructed using data from the UK's National Health Service. This paper also introduces eight "Frontier Archetypes", which represent common patterns of welfare generation observable in health organisations involved in programmes of change. These archetypes may be used in planning, monitoring or creating narratives about organisational journeys. Copyright © 2018 The Author. Published by Elsevier Ltd.. All rights reserved.

High Voltage Hall Accelerator Propulsion System Development for NASA Science Missions

NASA Technical Reports Server (NTRS)

Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Dankanich, John; Mathers, Alex

2013-01-01

NASA Science Mission Directorates In-Space Propulsion Technology Program is sponsoring the development of a 3.8 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn Research Center and Aerojet are developing a high fidelity high voltage Hall accelerator (HiVHAc) thruster that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the HiVHAc engineering development unit thruster have been performed. In addition, the HiVHAc project is also pursuing the development of a power processing unit (PPU) and xenon feed system (XFS) for integration with the HiVHAc engineering development unit thruster. Colorado Power Electronics and NASA Glenn Research Center have tested a brassboard PPU for more than 1,500 hours in a vacuum environment, and a new brassboard and engineering model PPU units are under development. VACCO Industries developed a xenon flow control module which has undergone qualification testing and will be integrated with the HiVHAc thruster extended duration tests. Finally, recent mission studies have shown that the HiVHAc propulsion system has sufficient performance for four Discovery- and two New Frontiers-class NASA design reference missions.

The Jupiter ONERA Electron (JOE) and Jupiter ONERA Proton (JOP) specification models

NASA Astrophysics Data System (ADS)

Bourdarie, S.; Sicard-Piet, A.

2008-09-01

The use of recent improvement in the understanding of the Jovian radiation belt structure has allowed to develop a more accurate engineering model of the Jovian electron and proton radiation belts. The basic idea was to combine the results of the Salammbô code when available (for proton and electron species) with the Divine and Garret model 1983 and/or with GIRE. The advantage of such an approach was that the resulting model is global in term of spatial and energy coverage, is optimised inside Europa orbit (the Divine and Garret model is not accurate inside Io orbit due to poor in-situ data there - note that inside Io is the region where ionizing radiation fluxes are maximum) and take advantage of the two models. The resulting JOE-JOP models will be presented, pro and cons will be listed and commented. Finally future plans to upgrade these models will be given.

The γ-subunit rotation and torque generation in F1-ATPase from wild-type or uncoupled mutant Escherichia coli

PubMed Central

Omote, Hiroshi; Sambonmatsu, Noriko; Saito, Kiwamu; Sambongi, Yoshihiro; Iwamoto-Kihara, Atsuko; Yanagida, Toshio; Wada, Yoh; Futai, Masamitsu

1999-01-01

The rotation of the γ-subunit has been included in the binding-change mechanism of ATP synthesis/hydrolysis by the proton ATP synthase (FOF1). The Escherichia coli ATP synthase was engineered for rotation studies such that its ATP hydrolysis and synthesis activity is similar to that of wild type. A fluorescently labeled actin filament connected to the γ-subunit of the F1 sector rotated on addition of ATP. This progress enabled us to analyze the γM23K (the γ-subunit Met-23 replaced by Lys) mutant, which is defective in energy coupling between catalysis and proton translocation. We found that the F1 sector produced essentially the same frictional torque, regardless of the mutation. These results suggest that the γM23K mutant is defective in the transformation of the mechanical work into proton translocation or vice versa. PMID:10393898

Atomic origins of water-vapour-promoted alloy oxidation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Langli; Su, Mao; Yan, Pengfei

The presence of water vapor, intentional or unavoidable, is crucial to many materials applications, such as steam generator, turbine engine, fuel cell, catalyst, and corrosion 1-6. Phenomenologically, water vapor has been noticed to accelerate oxidation of metals/alloys 7,8, however, the atomistic mechanisms remain elusive. Herein, through direct in situ atomic-scale transmission electron microscopy observation and density functional theory calculation, we reveal that water vapor enhanced oxidation of Ni-Cr alloy is associated with proton dissolution promoted vacancy formation, migration and clustering. Protons derived from water dissociation occupy interstitial position in the oxide lattice, which consequently leads to the lowering of bothmore » vacancy formation energy and the cation diffusion barrier. The atomic scale observations reveal a water vapor derived proton mediated oxide growth mechanism, which provides insights for reckoning many technological processes concerning materials in moist environment at elevated temperatures.« less

77 FR 39695 - HollyFrontier Refining and Marketing LLC v. Osage Pipe Line Company, LLC; Notice of Complaint

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR12-21-000] HollyFrontier Refining and Marketing LLC v. Osage Pipe Line Company, LLC; Notice of Complaint Take notice that on June 25...; 18 CFR 343.1(a) and 343.2(c), HollyFrontier Refining and Marketing LLC (Complainant) filed a formal...

Proximate Population Factors and Deforestation in Tropical Agricultural Frontiers

PubMed Central

Carr, David L.

2009-01-01

Forest conversion for agriculture expansion is the most salient signature of human occupation of the earth’s land surface. Although population growth and deforestation are significantly associated at the global and regional scales, evidence for population links to deforestation at micro-scales—where people are actually clearing0020forests—is scant. Much of the planet’s forest elimination is proceeding along tropical agricultural frontiers. This article examines the evolution of thought on population–environment theories relevant to deforestation in tropical agricultural frontiers. Four primary ways by which population dynamics interact with frontier forest conversion are examined: population density, fertility, and household demographic composition, and in-migration. PMID:19672475

Efficiently approximating the Pareto frontier: Hydropower dam placement in the Amazon basin

USGS Publications Warehouse

Wu, Xiaojian; Gomes-Selman, Jonathan; Shi, Qinru; Xue, Yexiang; Garcia-Villacorta, Roosevelt; Anderson, Elizabeth; Sethi, Suresh; Steinschneider, Scott; Flecker, Alexander; Gomes, Carla P.

2018-01-01

Real–world problems are often not fully characterized by a single optimal solution, as they frequently involve multiple competing objectives; it is therefore important to identify the so-called Pareto frontier, which captures solution trade-offs. We propose a fully polynomial-time approximation scheme based on Dynamic Programming (DP) for computing a polynomially succinct curve that approximates the Pareto frontier to within an arbitrarily small > 0 on treestructured networks. Given a set of objectives, our approximation scheme runs in time polynomial in the size of the instance and 1/. We also propose a Mixed Integer Programming (MIP) scheme to approximate the Pareto frontier. The DP and MIP Pareto frontier approaches have complementary strengths and are surprisingly effective. We provide empirical results showing that our methods outperform other approaches in efficiency and accuracy. Our work is motivated by a problem in computational sustainability concerning the proliferation of hydropower dams throughout the Amazon basin. Our goal is to support decision-makers in evaluating impacted ecosystem services on the full scale of the Amazon basin. Our work is general and can be applied to approximate the Pareto frontier of a variety of multiobjective problems on tree-structured networks.

Future HEP Accelerators: The US Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, Pushpalatha; Shiltsev, Vladimir

2015-11-02

Accelerator technology has advanced tremendously since the introduction of accelerators in the 1930s, and particle accelerators have become indispensable instruments in high energy physics (HEP) research to probe Nature at smaller and smaller distances. At present, accelerator facilities can be classified into Energy Frontier colliders that enable direct discoveries and studies of high mass scale particles and Intensity Frontier accelerators for exploration of extremely rare processes, usually at relatively low energies. The near term strategies of the global energy frontier particle physics community are centered on fully exploiting the physics potential of the Large Hadron Collider (LHC) at CERN throughmore » its high-luminosity upgrade (HL-LHC), while the intensity frontier HEP research is focused on studies of neutrinos at the MW-scale beam power accelerator facilities, such as Fermilab Main Injector with the planned PIP-II SRF linac project. A number of next generation accelerator facilities have been proposed and are currently under consideration for the medium- and long-term future programs of accelerator-based HEP research. In this paper, we briefly review the post-LHC energy frontier options, both for lepton and hadron colliders in various regions of the world, as well as possible future intensity frontier accelerator facilities.« less

The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Mao, Ho-kwang (Director, Center for Energy Frontier Research in Extreme Environments); EFree Staff

2017-12-09

'The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales ' was submitted by the Center for Energy Frontier Research in Extreme Environments (EFree) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFree is directed by Ho-kwang Mao at the Carnegie Institute of Washington and is a partnership of scientists from thirteen institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of Energy Frontier Research in Extreme Environments is 'to accelerate the discovery and creation of energy-relevant materials using extreme pressures and temperatures.' Research topics are: catalysis (CO{sub 2}, water), photocatalysis, solid state lighting, optics, thermelectric, phonons, thermal conductivity, solar electrodes, fuel cells, superconductivity, extreme environment, radiation effects, defects, spin dynamics, CO{sub 2} (capture, convert, store), greenhouse gas, hydrogen (fuel, storage), ultrafast physics, novel materials synthesis, and defect tolerant materials.

Particle Physics at the Cosmic, Intensity, and Energy Frontiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Essig, Rouven

Major efforts at the Intensity, Cosmic, and Energy frontiers of particle physics are rapidly furthering our understanding of the fundamental constituents of Nature and their interactions. The overall objectives of this research project are (1) to interpret and develop the theoretical implications of the data collected at these frontiers and (2) to provide the theoretical motivation, basis, and ideas for new experiments and for new analyses of experimental data. Within the Intensity Frontier, an experimental search for a new force mediated by a GeV-scale gauge boson will be carried out with the $A'$ Experiment (APEX) and the Heavy Photon Searchmore » (HPS), both at Jefferson Laboratory. Within the Cosmic Frontier, contributions are planned to the search for dark matter particles with the Fermi Gamma-ray Space Telescope and other instruments. A detailed exploration will also be performed of new direct detection strategies for dark matter particles with sub-GeV masses to facilitate the development of new experiments. In addition, the theoretical implications of existing and future dark matter-related anomalies will be examined. Within the Energy Frontier, the implications of the data from the Large Hadron Collider will be investigated. Novel search strategies will be developed to aid the search for new phenomena not described by the Standard Model of particle physics. By combining insights from all three particle physics frontiers, this research aims to increase our understanding of fundamental particle physics.« less

Lateral movements in Rayleigh-Taylor instabilities due to frontiers. Numerical analysis

NASA Astrophysics Data System (ADS)

Fernandez, D.; Binda, L.; Zalts, A.; El Hasi, C.; D'Onofrio, A.

2018-01-01

Numerical simulations were performed for Rayleigh-Taylor (RT) hydrodynamic instabilities when a frontier is present. The frontier formed by the interface between two fluids prevents the free movement of the fingers created by the instability. As a consequence, transversal movements at the rear of the fingers are observed in this area. These movements produce collapse of the fingers (two or more fingers join in one finger) or oscillations in the case that there is no collapse. The transversal velocity of the fingers, the amplitude of the oscillations, and the wave number of the RT instabilities as a function of the Rayleigh number (Ra) were studied near the frontier. We verified numerically that in classical RT instabilities, without a frontier, these lateral movements do not occur; only with a physical frontier, the transversal displacements of the fingers appear. The transverse displacement velocity and the initial wave number increase with Ra. This leads to the collapse of the fingers, diminishing the wave number of the instabilities at the interface. Instead, no significant changes in the amplitude of the oscillations are observed modifying Ra. The numerical results are independent of the type or origin of the frontier (gas-liquid, liquid-liquid, or solid-liquid). The numerical results are in good agreement with the experimental results reported by Binda et al. [Chaos 28, 013107 (2018)]. Based on these results, it was possible to determine the cause of the transverse displacements, which had not been explained until now.

Light-Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch.

PubMed

Berbasova, Tetyana; Santos, Elizabeth M; Nosrati, Meisam; Vasileiou, Chrysoula; Geiger, James H; Borhan, Babak

2016-03-02

Mutants of cellular retinoic acid-binding protein II (CRABPII), engineered to bind all-trans-retinal as an iminium species, demonstrate photochromism upon irradiation with light at different wavelengths. UV light irradiation populates the cis-imine geometry, which has a high pKa , leading to protonation of the imine and subsequent "turn-on" of color. Yellow light irradiation yields the trans-imine isomer, which has a depressed pKa , leading to loss of color because the imine is not protonated. The protein-bound retinylidene chromophore undergoes photoinduced reversible interconversion between the colored and uncolored species, with excellent fatigue resistance. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Naked-eye optical flash from gamma-ray burst 080319B: Tracing the decaying neutrons in the outflow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan Yizhong; Zhang Bing; Wei Daming

For an unsteady baryonic gamma-ray burst (GRB) outflow, the fast and slow proton shells collide with each other and produce energetic soft gamma-ray emission. If the outflow has a significant neutron component, the ultrarelativistic neutrons initially expand freely until decaying at a larger radius. The late-time proton shells ejected from the GRB central engine, after powering the regular internal shocks, will sweep these {beta}-decay products and give rise to very bright UV/optical emission. The naked-eye optical flash from GRB 080319B, an energetic explosion in the distant Universe, can be well explained in this way.

High Energy Colliding Beams; What Is Their Future?

NASA Astrophysics Data System (ADS)

Richter, Burton

The success of the first few years of LHC operations at CERN, and the expectation of more to come as the LHC's performance improves, are already leading to discussions of what should be next for both proton-proton and electron-positron colliders. In this discussion I see too much theoretical desperation caused by the so-far-unsuccessful hunt for what is beyond the Standard Model, and too little of the necessary interaction of the accelerator, experimenter, and theory communities necessary for a scientific and engineering success. Here, I give my impressions of the problem, its possible solution, and what is needed to have both a scientifically productive and financially viable future.

High Energy Colliding Beams; What Is Their Future?

NASA Astrophysics Data System (ADS)

Richter, Burton

2014-04-01

The success of the first few years of LHC operations at CERN, and the expectation of more to come as the LHC's performance improves, are already leading to discussions of what should be next for both proton-proton and electron-positron colliders. In this discussion I see too much theoretical desperation caused by the so-far-unsuccessful hunt for what is beyond the Standard Model, and too little of the necessary interaction of the accelerator, experimenter, and theory communities necessary for a scientific and engineering success. Here, I give my impressions of the problem, its possible solution, and what is needed to have both a scientifically productive and financially viable future.

High Energy Colliding Beams; What Is Their Future?

NASA Astrophysics Data System (ADS)

Richter, Burton

2015-02-01

The success of the first few years of LHC operations at CERN, and the expectation of more to come as the LHC's performance improves, are already leading to discussions of what should be next for both proton-proton and electron-positron colliders. In this discussion I see too much theoretical desperation caused by the so-far-unsuccessful hunt for what is beyond the Standard Model, and too little of the necessary interaction of the accelerator, experimenter, and theory communities necessary for a scientific and engineering success. Here, I give my impressions of the problem, its possible solution, and what is needed to have both a scientifically productive and financially viable future.

Protonation Studies of a Tungsten Dinitrogen Complex Supported by a Diphosphine Ligand Containing a Pendant Amine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weiss, Charles J.; Egbert, Jonathan D.; Chen, Shentan

2014-04-28

Treatment of trans-[W(N2)2(dppe)(PEtNMePEt)] (dppe = Ph2PCH2CH2PPh2; PEtNMePEt = Et2PCH2N(Me)CH2PEt2) with three equivalents of tetrafluoroboric acid (HBF4∙Et2O) at -78 °C generated the seven-coordinate tungsten hydride trans-[W(N2)2(H)(dppe)(PEtNMePEt)][BF4]. Depending on the temperature of the reaction, protonation of a pendant amine is also observed, affording trans-[W(N2)2(H)(dppe)(PEtNMe(H)PEt)][BF4]2, with formation of the hydrazido complex, [W(NNH2)(dppe)(PEtNMe(H)PEt)][BF4]2, as a minor product. Similar product mixtures were obtained using triflic acid (HOTf). Upon acid addition to the carbonyl analogue, cis-[W(CO)2(dppe)(PEtNMePEt)], the seven-coordinate carbonyl-hydride complex, trans-[W(CO)2(H)(dppe)(PEtN(H)MePEt)][OTf]2 was generated. The mixed diphosphine complex without the pendant amine in the ligand backbone, trans-[W(N2)2(dppe)(depp)] (depp = Et2P(CH2)3PEt2), was synthesized and treated with HBF4∙Et2O, selectivelymore » generating a hydrazido complex, [W(NNH2)(F)(dppe)(depp)][BF4]. Computational analysis was used to probe proton affinity of three sites of protonation, the metal, pendant amine, and N2 ligand in these complexes. Room temperature reactions with 100 equivalents of HOTf produced NH4+ from reduction of the N2 ligand (electrons come from W). The addition of 100 equivalents HOTf to trans-[W(N2)2(dppe)(PEtNMePEt)] afforded 0.88 ± 0.02 equivalents NH4+, while 0.36 ± 0.02 equivalents of NH4+was formed upon treatment of trans-[W(N2)2(dppe)(depp)], the complex without the pendant amine. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy Office of Science, Office of Basic Energy Sciences. Computational resources were provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory. Pacific Northwest National Laboratory is operated by Battelle for DOE.« less

Design and Development of a Prototype Permanent Magnet for Focusing/Defocusing for Electron-Ion Colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, Bob

Electron-ion colliders (EIC) have been identified as an ideal tool to study the next frontier of nuclear physics – the gluon force that holds the building blocks of matter together, and which is a fundamental component of the theory of Quantum Chromodynamics (QCD). Future electron-ion colliders under consideration can be based on the Energy Recovery Linac (ERL) architecture. The beam lines for this architecture could be built of the newly developed Non-Scaling Fixed Field Alternating Gradient (NS FFAG) structure, so that they can transfer multiple energies within the same aperture. This structure allows for the use of compact, economical quadupolemore » permanent magnets. In this SBIR, we propose to design and to manufacture prototype quadrupole permanent magnets of focusing/defocusing combined function for use in this beam line. For our SBIR project, we proposed to design and build the focusing/defocusing quadrupole with a gradient strength of 50 T/m and with a beam gap of 16mm. The proposed permanent magnet material is SmCo because of its higher radiation resistance as compared to NdBFe2. The use of permanent magnets will reduce the overall cost. For Phase I, we took a recent design by Dr. Dejan Trbojevic, and reran Tosca code on the design to optimize the iron yoke with respect to the thickness of SmCo. We then fabricated one prototype focusing/defocusing combined function quadruple and measured field quality dG/Go. Our plan for Phase II is that, based on our Phase I prototype experience, we shall improve the design and fabricate a production quadruple, and design and incorporate coils for skew dipoles and normal quadrupole correctors, etc. In addition, we shall fabricate enough quadrupoles for one cell. The development of quadrupole permanent magnets is of fundamental importance for there application in the future electron-ion colliders. This accelerator structure will also advance the development of muon accelerators and allow for the development of compact, simplified, less expensive proton accelerators which will promote their use in areas such as proton cancer therapy, and for high-power proton drivers for tritium and neutron production, waste transmutation, driving a sub-critical nuclear reactor to produce energy, cargo contain inspection, and radioisotope production. Proton cancer therapy has been identified as a particularly attractive and viable commercial application for the immediate future.« less

Organic positive ions in aircraft gas-turbine engine exhaust

NASA Astrophysics Data System (ADS)

Sorokin, Andrey; Arnold, Frank

Volatile organic compounds (VOCs) represent a significant fraction of atmospheric aerosol. However the role of organic species emitted by aircraft (as a consequence of the incomplete combustion of fuel in the engine) in nucleation of new volatile particles still remains rather speculative and requires a much more detailed analysis of the underlying mechanisms. Measurements in aircraft exhaust plumes have shown the presence of both different non-methane VOCs (e.g. PartEmis project) and numerous organic cluster ions (MPIK-Heidelberg). However the link between detected organic gas-phase species and measured mass spectrum of cluster ions is uncertain. Unfortunately, up to now there are no models describing the thermodynamics of the formation of primary organic cluster ions in the exhaust of aircraft engines. The aim of this work is to present first results of such a model development. The model includes the block of thermodynamic data based on proton affinities and gas basicities of organic molecules and the block of non-equilibrium kinetics of the cluster ions evolution in the exhaust. The model predicts important features of the measured spectrum of positive ions in the exhaust behind aircraft. It is shown that positive ions emitted by aircraft engines into the atmosphere mostly consist of protonated and hydrated organic cluster ions. The developed model may be explored also in aerosol investigations of the background atmosphere as well as in the analysis of the emission of fine aerosol particles by automobiles.

Some Historical Background to the Country School Legacy: Frontier and Rural Schools in Colorado, 1859-1950. Country School Legacy: Humanities on the Frontier.

ERIC Educational Resources Information Center

Johnson, Charlie H., Jr.

A study of historical background of the frontier and rural schools in Colorado describes education in the United State in general and the development of the educational process and school facilities during five phases of Colorado's economic and political development. "The Nation" discusses philosophies generally held during the middle…

ATP synthase--a marvellous rotary engine of the cell.

PubMed

Yoshida, M; Muneyuki, E; Hisabori, T

2001-09-01

ATP synthase can be thought of as a complex of two motors--the ATP-driven F1 motor and the proton-driven Fo motor--that rotate in opposite directions. The mechanisms by which rotation and catalysis are coupled in the working enzyme are now being unravelled on a molecular scale.

Research in High Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, Robert John; Toki, Walter; Harton, John

This report summarizes research performed within the Department of Energy Office of Science's Intensity Frontier and Cosmic Frontier High Energy Physics research subprograms during the period 2014-17. The major research thrusts in the Intensity Frontier involved two currently active neutrino experiments T2K and NOvA; participation in development for the new Short-Baseline Neutrino program at Fermilab (SBN), which will begin full operation within the next one to two years; and physics tools, analysis and detector prototyping for the future Deep Underground Neutrino Experiment (DUNE). The major research thrusts in the Cosmic Frontier involved the Pierre Auger Observatory and the Directional Recoilmore » Identification From Tracks (DRIFT) dark matter search experiment.« less

Ongoing Voluntary Settlement and Independent Agency: Evidence from China

PubMed Central

Feng, Jing; Ren, Xiaopeng; Ma, Xinran

2017-01-01

Voluntary frontier settlement leads to independent agency. Since this type of research has not yet been implemented in ongoing voluntary settlement frontiers, we conducted several cultural tasks to investigate Shenzhen, known as China’s ongoing “South Frontier,” which is composed mostly of people that have emigrated from other Chinese provinces within the past 30 years. We hypothesized that residents of Shenzhen are more independent than those in other regions of Mainland China. As predicted, residents of Shenzhen scored higher than China inland residents in self-reported independent beliefs and scored lower in nepotism. The results indicate that, even in a short-term ongoing frontier, voluntary settlement is associated with independent agency. PMID:28798712

General-Purpose Front End for Real-Time Data Processing

NASA Technical Reports Server (NTRS)

James, Mark

2007-01-01

FRONTIER is a computer program that functions as a front end for any of a variety of other software of both the artificial intelligence (AI) and conventional data-processing types. As used here, front end signifies interface software needed for acquiring and preprocessing data and making the data available for analysis by the other software. FRONTIER is reusable in that it can be rapidly tailored to any such other software with minimum effort. Each component of FRONTIER is programmable and is executed in an embedded virtual machine. Each component can be reconfigured during execution. The virtual-machine implementation making FRONTIER independent of the type of computing hardware on which it is executed.

Charge transfer complex between 2,3-diaminopyridine with chloranilic acid. Synthesis, characterization and DFT, TD-DFT computational studies

NASA Astrophysics Data System (ADS)

Al-Ahmary, Khairia M.; Habeeb, Moustafa M.; Al-Obidan, Areej H.

2018-05-01

New charge transfer complex (CTC) between the electron donor 2,3-diaminopyridine (DAP) with the electron acceptor chloranilic (CLA) acid has been synthesized and characterized experimentally and theoretically using a variety of physicochemical techniques. The experimental work included the use of elemental analysis, UV-vis, IR and 1H NMR studies to characterize the complex. Electronic spectra have been carried out in different hydrogen bonded solvents, methanol (MeOH), acetonitrile (AN) and 1:1 mixture from AN-MeOH. The molecular composition of the complex was identified to be 1:1 from Jobs and molar ratio methods. The stability constant was determined using minimum-maximum absorbances method where it recorded high values confirming the high stability of the formed complex. The solid complex was prepared and characterized by elemental analysis that confirmed its formation in 1:1 stoichiometric ratio. Both IR and NMR studies asserted the existence of proton and charge transfers in the formed complex. For supporting the experimental results, DFT computations were carried out using B3LYP/6-31G(d,p) method to compute the optimized structures of the reactants and complex, their geometrical parameters, reactivity parameters, molecular electrostatic potential map and frontier molecular orbitals. The analysis of DFT results strongly confirmed the high stability of the formed complex based on existing charge transfer beside proton transfer hydrogen bonding concordant with experimental results. The origin of electronic spectra was analyzed using TD-DFT method where the observed λmax are strongly consisted with the computed ones. TD-DFT showed the contributed states for various electronic transitions.

Using Combinations of Oxidants and Bases as PCET Reactants: Thermochemical and Practical Considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waidmann, Christopher R.; Miller, Alexander J.; Ng, Cheuk-Wa A.

Studies in proton-coupled electron transfer (PCET) often require the combination of an outer-sphere oxidant and a base, to remove an electron and a proton. A common problem is the incompatibility of the oxidant and the base, because the former is electron deficient and the latter electron rich. We have tested a variety of reagents and report a number of oxidant/base combinations that are compatible and therefore potentially useful as PCET reagents. A formal bond dissociation free energy (BDFE) for a reagent combination is defined by the redox potential of the oxidant and pKa of the base. This is a formalmore » BDFE because no X-H bond is homolytically cleaved, but it is a very useful way to categorize the H• accepting ability of an oxidant/base PCET pair. Formal BDFEs of stable oxidant/base combinations range from 71 to at least 100 kcal mol-1. Effects of solvent, concentration, temperature, and counterions on the stability of the oxidant/base combinations are discussed. Possible extensions to related reductant/acid combinations are mentioned. We gratefully acknowledge the financial support of the U.S. National Science Foundation Center for Enabling New Technologies through Catalysis, the Camille and Henry Dreyfus Postdoctoral Program in Environmental Chemistry (for a fellowship to A.J.M.M.), the U.S. National Institutes of Health (grant GM-50422), and the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences.« less

Three-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystals

PubMed Central

Liu, Deming; Xu, Xiaoxue; Du, Yi; Qin, Xian; Zhang, Yuhai; Ma, Chenshuo; Wen, Shihui; Ren, Wei; Goldys, Ewa M.; Piper, James A.; Dou, Shixue; Liu, Xiaogang; Jin, Dayong

2016-01-01

The ultimate frontier in nanomaterials engineering is to realize their composition control with atomic scale precision to enable fabrication of nanoparticles with desirable size, shape and surface properties. Such control becomes even more useful when growing hybrid nanocrystals designed to integrate multiple functionalities. Here we report achieving such degree of control in a family of rare-earth-doped nanomaterials. We experimentally verify the co-existence and different roles of oleate anions (OA−) and molecules (OAH) in the crystal formation. We identify that the control over the ratio of OA− to OAH can be used to directionally inhibit, promote or etch the crystallographic facets of the nanoparticles. This control enables selective grafting of shells with complex morphologies grown over nanocrystal cores, thus allowing the fabrication of a diverse library of monodisperse sub-50 nm nanoparticles. With such programmable additive and subtractive engineering a variety of three-dimensional shapes can be implemented using a bottom–up scalable approach. PMID:26743184

A network engineering perspective on probing and perturbing cognition with neurofeedback.

PubMed

Bassett, Danielle S; Khambhati, Ankit N

2017-05-01

Network science and engineering provide a flexible and generalizable tool set to describe and manipulate complex systems characterized by heterogeneous interaction patterns among component parts. While classically applied to social systems, these tools have recently proven to be particularly useful in the study of the brain. In this review, we describe the nascent use of these tools to understand human cognition, and we discuss their utility in informing the meaningful and predictable perturbation of cognition in combination with the emerging capabilities of neurofeedback. To blend these disparate strands of research, we build on emerging conceptualizations of how the brain functions (as a complex network) and how we can develop and target interventions or modulations (as a form of network control). We close with an outline of current frontiers that bridge neurofeedback, connectomics, and network control theory to better understand human cognition. © 2017 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.

Synthetic biology engineering of biofilms as nanomaterials factories.

PubMed

Nguyen, Peter Q

2017-06-15

Bottom-up fabrication of nanoscale materials has been a significant focus in materials science for expanding our technological frontiers. This assembly concept, however, is old news to biology - all living organisms fabricate themselves using bottom-up principles through a vast self-organizing system of incredibly complex biomolecules, a marvelous dynamic that we are still attempting to unravel. Can we use what we have gleaned from biology thus far to illuminate alternative strategies for designer nanomaterial manufacturing? In the present review article, new synthetic biology efforts toward using bacterial biofilms as platforms for the synthesis and secretion of programmable nanomaterials are described. Particular focus is given to self-assembling functional amyloids found in bacterial biofilms as re-engineerable modular nanomolecular components. Potential applications and existing challenges for this technology are also explored. This novel approach for repurposing biofilm systems will enable future technologies for using engineered living systems to grow artificial nanomaterials. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

Undergraduate Research in Physics as an Educational Tool

NASA Astrophysics Data System (ADS)

Hakim, Toufic M.; Garg, Shila

2001-03-01

The National Science Foundation's 1996 report "Shaping the Future: New Expectations for Undergraduate Education in Science, Mathematics, Engineering and Technology" urged that in order to improve SME&T education, decisive action must be taken so that "all students have access to excellent undergraduate education in science .... and all students learn these subjects by direct experience with the methods and processes of inquiry." Research-related educational activities that integrate education and research have been shown to be valuable in improving the quality of education and enhancing the number of majors in physics departments. Student researchers develop a motivation to continue in science and engineering through an appreciation of how science is done and the excitement of doing frontier research. We will address some of the challenges of integrating research into the physics undergraduate curriculum effectively. The departmental and institutional policies and infrastructure required to help prepare students for this endeavor will be discussed as well as sources of support and the establishment of appropriate evaluation procedures.

Verification of combined thermal-hydraulic and heat conduction analysis code FLOWNET/TRUMP

NASA Astrophysics Data System (ADS)

Maruyama, Soh; Fujimoto, Nozomu; Kiso, Yoshihiro; Murakami, Tomoyuki; Sudo, Yukio

1988-09-01

This report presents the verification results of the combined thermal-hydraulic and heat conduction analysis code, FLOWNET/TRUMP which has been utilized for the core thermal hydraulic design, especially for the analysis of flow distribution among fuel block coolant channels, the determination of thermal boundary conditions for fuel block stress analysis and the estimation of fuel temperature in the case of fuel block coolant channel blockage accident in the design of the High Temperature Engineering Test Reactor(HTTR), which the Japan Atomic Energy Research Institute has been planning to construct in order to establish basic technologies for future advanced very high temperature gas-cooled reactors and to be served as an irradiation test reactor for promotion of innovative high temperature new frontier technologies. The verification of the code was done through the comparison between the analytical results and experimental results of the Helium Engineering Demonstration Loop Multi-channel Test Section(HENDEL T(sub 1-M)) with simulated fuel rods and fuel blocks.

Meet Temilola Fatoyinbo-Agueh

NASA Image and Video Library

2017-12-08

President Obama has named six NASA individuals as recipients of the 2011 Presidential Early Career Award for Scientists and Engineers (PECASE). Temilola "Lola" Fatoyinbo-Agueh, an environmental scientist from NASA's Goddard Space Flight Center, Greenbelt, Md. was one of the recipients. The PECASE awards represent the highest honor bestowed by the U.S. government on scientists and engineers beginning their independent careers. They recognize recipients' exceptional potential for leadership at the frontiers of scientific knowledge, and their commitment to community service as demonstrated through professional leadership, education or community outreach. To read more go to: www.nasa.gov/centers/goddard/news/releases/2012/12-064.html Credit: NASA/GSFC/Chris Gunn NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.

PubMed

Beavis, Paul A; Slaney, Clare Y; Kershaw, Michael H; Gyorki, David; Neeson, Paul J; Darcy, Phillip K

2016-02-01

The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted and the types of therapeutics that are in clinical development. The use of adoptive cellular therapy (ACT) and its derivative, chimeric antigen receptor (CAR) T cells, is currently limited to hematological malignancies and immunogenic cancers such as melanoma and renal cell carcinoma. Although ACT utilizing ex vivo expanded tumor-infiltrating lymphocytes (TIL) or engineered CAR/TCR T cells have undergone clinical trials for other solid cancers, their efficacy to date has been limited. This may be due, in part, to the immunosuppressive nature of the tumor microenvironment. The development of novel combination approaches which target the immunosuppressive network engineered by tumors has raised the possibility of using ACT for a broader range of cancers. This review summarizes the potential of such strategies and outlines the clinical relevance of these observations. Copyright © 2015 Elsevier Ltd. All rights reserved.

Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

PubMed Central

2016-01-01

Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation. PMID:27516776

Not Just a Game … When We Play Together, We Learn Together: Interactive Virtual Environments and Gaming Engines for Geospatial Visualization

NASA Astrophysics Data System (ADS)

Shipman, J. S.; Anderson, J. W.

2017-12-01

An ideal tool for ecologists and land managers to investigate the impacts of both projected environmental changes and policy alternatives is the creation of immersive, interactive, virtual landscapes. As a new frontier in visualizing and understanding geospatial data, virtual landscapes require a new toolbox for data visualization that includes traditional GIS tools and uncommon tools such as the Unity3d game engine. Game engines provide capabilities to not only explore data but to build and interact with dynamic models collaboratively. These virtual worlds can be used to display and illustrate data that is often more understandable and plausible to both stakeholders and policy makers than is achieved using traditional maps.Within this context we will present funded research that has been developed utilizing virtual landscapes for geographic visualization and decision support among varied stakeholders. We will highlight the challenges and lessons learned when developing interactive virtual environments that require large multidisciplinary team efforts with varied competences. The results will emphasize the importance of visualization and interactive virtual environments and the link with emerging research disciplines within Visual Analytics.

Using Quality Attributes to Bridge Systems Engineering Gaps : A Juno Ground Data Systems Case Study

NASA Technical Reports Server (NTRS)

Dubon, Lydia P.; Jackson, Maddalena M.; Thornton, Marla S.

2012-01-01

The Juno Mission to Jupiter is the second mission selected by the NASA New Frontiers Program. Juno launched August 2011 and will reach Jupiter July 2016. Juno's payload system is composed of nine instruments plus a gravity science experiment. One of the primary functions of the Juno Ground Data System (GDS) is the assembly and distribution of the CFDP (CCSDS File Delivery Protocol) product telemetry, also referred to as raw science data, for eight out of the nine instruments. The GDS accomplishes this with the Instrument Data Pipeline (IDP). During payload integration, the first attempt to exercise the IDP in a flight like manner revealed that although the functional requirements were well understood, the system was unable to meet latency requirements with the as-is heritage design. A systems engineering gap emerged between Juno instrument data delivery requirements and the assumptions behind the heritage flight-ground interactions. This paper describes the use of quality attributes to measure and overcome this gap by introducing a new systems engineering activity, and a new monitoring service architecture that successfully delivered the performance metrics needed to validate Juno IDP.

PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blankenship, Robert E.

"PARC - Scientific Exchange Program" was submitted by the Photosynthetic Antenna Research Center (PARC) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) inmore » 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Electricity: The Energy of Tomorrow (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

"Electricity: the Energy of Tomorrow" was submitted by the Energy Materials Center at Cornell (emc2) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. emc2, an EFRC directed by Hector D. Abruna at Cornell University (lead) is a partnership between Cornell and Lawrence Berkeley National Laboratory. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs)more » in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Electricity: The Energy of Tomorrow (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Abruna, Hector D. (Director, Energy Materials Center at Cornell); emc2 Staff

2017-12-09

'Electricity: the Energy of Tomorrow' was submitted by the Energy Materials Center at Cornell (emc2) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. emc2, an EFRC directed by Hector D. Abruna at Cornell University (lead) is a partnership between Cornell and Lawrence Berkeley National Laboratory. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

2017-12-09

'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

TU-EF-304-03: 4D Monte Carlo Robustness Test for Proton Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Souris, K; Sterpin, E; Lee, J

Purpose: Breathing motion and approximate dose calculation engines may increase proton range uncertainties. We address these two issues using a comprehensive 4D robustness evaluation tool based on an efficient Monte Carlo (MC) engine, which can simulate breathing with no significant increase in computation time. Methods: To assess the robustness of the treatment plan, multiple scenarios of uncertainties are simulated, taking into account the systematic and random setup errors, range uncertainties, and organ motion. Our fast MC dose engine, called MCsquare, implements optimized models on a massively-parallel computation architecture and allows us to accurately simulate a scenario in less than onemore » minute. The deviations of the uncertainty scenarios are then reported on a DVH-band and compared to the nominal plan.The robustness evaluation tool is illustrated in a lung case by comparing three 60Gy treatment plans. First, a plan is optimized on a PTV obtained by extending the CTV with an 8mm margin, in order to take into account systematic geometrical uncertainties, like in our current practice in radiotherapy. No specific strategy is employed to correct for tumor and organ motions. The second plan involves a PTV generated from the ITV, which encompasses the tumor volume in all breathing phases. The last plan results from robust optimization performed on the ITV, with robustness parameters of 3% for tissue density and 8 mm for positioning errors. Results: The robustness test revealed that the first two plans could not properly cover the target in the presence of uncertainties. CTV-coverage (D95) in the three plans ranged respectively between 39.4–55.5Gy, 50.2–57.5Gy, and 55.1–58.6Gy. Conclusion: A realistic robustness verification tool based on a fast MC dose engine has been developed. This test is essential to assess the quality of proton therapy plan and very useful to study various planning strategies for mobile tumors. This work is partly funded by IBA (Louvain-la-Neuve, Belgium)« less

Thematic Conference on Remote Sensing for Exploration Geology, 6th, Houston, TX, May 16-19, 1988, Proceedings. Volumes 1 & 2

NASA Technical Reports Server (NTRS)

1988-01-01

Papers concerning remote sensing applications for exploration geology are presented, covering topics such as remote sensing technology, data availability, frontier exploration, and exploration in mature basins. Other topics include offshore applications, geobotany, mineral exploration, engineering and environmental applications, image processing, and prospects for future developments in remote sensing for exploration geology. Consideration is given to the use of data from Landsat, MSS, TM, SAR, short wavelength IR, the Geophysical Environmental Research Airborne Scanner, gas chromatography, sonar imaging, the Airborne Visible-IR Imaging Spectrometer, field spectrometry, airborne thermal IR scanners, SPOT, AVHRR, SIR, the Large Format camera, and multitimephase satellite photographs.

The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors.

PubMed

Zander, Ryan; Cui, Weiguo

2017-10-03

Recent advancements in adoptive cell therapy (ACT) are opening up new frontiers for cancer immunotherapy. CAR T cells targeting CD19 have emerged as a remarkable T cell-based therapy for the successful treatment of certain types of leukemia and lymphomas. Despite these clinical successes, as well as significant breakthroughs in T cell engineering, the treatment of solid tumors with ACT remains a relentless challenge. Thus, the current consensus of the field is that an urgent need exists for the design of innovative approaches that can improve the efficacy of ACT in treating solid cancers while maintaining a high degree of reliability and safety.

70 Years of Aeropropulsion Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Reddy, Dhanireddy R.

2013-01-01

This paper presents a brief overview of air-breathing propulsion research conducted at the NASA Glenn Research Center (GRC) over the past 70 years. It includes a historical perspective of the center and its various stages of propulsion research in response to the countrys different periods of crises and growth opportunities. GRCs research and technology development covered a broad spectrum, from a short-term focus on improving the energy efficiency of aircraft engines to advancing the frontier technologies of high-speed aviation in the supersonic and hypersonic speed regimes. This paper highlights major research programs, showing their impact on industry and aircraft propulsion, and briefly discusses current research programs and future aeropropulsion technology trends in related areas

The Open Gateway: Lunar Exploration in 2050

NASA Technical Reports Server (NTRS)

Lawrence, S.; Neal, C.

2017-01-01

The Moon, with its fundamental science questions and abundant, potentially useful re-sources, is the most viable destination for near-term future human and robotic exploration. Given what we have learned since Apollo, the lunar frontier now presents an entirely new paradigm for planetary exploration. The Lunar Exploration Roadmap [1], which was jointly developed by engineers, planetary scientists, commercial entities, and policymakers, is the cohesive strategic plan for using the Moon and its resources to enable the exploration of all other destinations within the Solar system by leveraging incremental, affordable investments in cislunar infrastructure. Here, we summarize the Lunar Exploration Roadmap, and describe the immense benefits that will arise from its successful implementation.

How to Store Energy Fast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Augustyn, Veronica; Ko, Jesse; Rauda, Iris

Representing the Molecularly Engineered Energy Materials (MEEM), this document is one of the entries in the Ten Hundred and One Word Challenge. As part of the challenge, the 46 Energy Frontier Research Centers were invited to represent their science in images, cartoons, photos, words and original paintings, but any descriptions or words could only use the 1000 most commonly used words in the English language, with the addition of one word important to each of the EFRCs and the mission of DOE energy. The mission of MEEM, using inexpensive custom-designed molecular building blocks, aims to create revolutionary new materials withmore » self-assembled multi-scale architectures that will enable high performing energy generation and storage applications.« less

The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

"The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales" was submitted by the Center for Energy Frontier Research in Extreme Environments (EFree) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFree is directed by Ho-kwang Mao at the Carnegie Institute of Science in Washington, DC and is a partnership of scientists from thirteen institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office ofmore » Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of Energy Frontier Research in Extreme Environments is 'to accelerate the discovery and creation of energy-relevant materials using extreme pressures and temperatures.' Research topics are: catalysis (CO2, water), photocatalysis, solid state lighting, optics, thermelectric, phonons, thermal conductivity, solar electrodes, fuel cells, superconductivity, extreme environment, radiation effects, defects, spin dynamics, CO2 (capture, convert, store), greenhouse gas, hydrogen (fuel, storage), ultrafast physics, novel materials synthesis, and defect tolerant materials.« less

The Hubble Frontier Fields: Engaging Multiple Audiences in Exploring the Cosmic Frontier

NASA Astrophysics Data System (ADS)

Lawton, Brandon L.; Smith, Denise A.; Summers, Frank; Ryer, Holly; Slivinski, Carolyn; Lotz, Jennifer M.

2017-06-01

The Hubble Frontier Fields is a multi-cycle program of six deep-field observations of strong-lensing galaxy clusters taken in parallel with six deep “blank fields.” The three-year long collaborative program began in late 2013 and is led by observations from NASA’s Great Observatories. The observations, now complete, allow astronomers to look deeper into the universe than ever before, and potentially uncover galaxies that are as much as 100 times fainter than what the telescopes can typically observe. The Frontier Fields science program is ideal for informing audiences about scientific advances and topics in STEM. The study of galaxy properties, statistics, optics, and Einstein’s theory of general relativity naturally leverages off of the science returns of the Frontier Fields program. As a result, the Space Telescope Science Institute’s Office of Public Outreach (OPO) has engaged multiple audiences over the past three years to follow the progress of the Frontier Fields.For over two decades, the STScI outreach program has sought to bring the wonders of the universe to the public and engage audiences in the adventure of scientific discovery. In addition, we are leveraging the reach of the new NASA’s Universe of Learning education program to bring the science of the Frontier Fields to informal education audiences. The main underpinnings of the STScI outreach program and the Universe of Learning education program are scientist-educator development teams, partnerships, and an embedded program evaluation component. OPO is leveraging the infrastructure of these education and outreach programs to bring the Frontier Fields science program to the education community and the public in a cost-effective way.This talk will feature highlights over the past three years of the program. We will highlight OPO’s strategies and infrastructure that allows for the quick delivery of groundbreaking science to the education community and public.

Data-Driven Benchmarking of Building Energy Efficiency Utilizing Statistical Frontier Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kavousian, A; Rajagopal, R

2014-01-01

Frontier methods quantify the energy efficiency of buildings by forming an efficient frontier (best-practice technology) and by comparing all buildings against that frontier. Because energy consumption fluctuates over time, the efficiency scores are stochastic random variables. Existing applications of frontier methods in energy efficiency either treat efficiency scores as deterministic values or estimate their uncertainty by resampling from one set of measurements. Availability of smart meter data (repeated measurements of energy consumption of buildings) enables using actual data to estimate the uncertainty in efficiency scores. Additionally, existing applications assume a linear form for an efficient frontier; i.e.,they assume that themore » best-practice technology scales up and down proportionally with building characteristics. However, previous research shows that buildings are nonlinear systems. This paper proposes a statistical method called stochastic energy efficiency frontier (SEEF) to estimate a bias-corrected efficiency score and its confidence intervals from measured data. The paper proposes an algorithm to specify the functional form of the frontier, identify the probability distribution of the efficiency score of each building using measured data, and rank buildings based on their energy efficiency. To illustrate the power of SEEF, this paper presents the results from applying SEEF on a smart meter data set of 307 residential buildings in the United States. SEEF efficiency scores are used to rank individual buildings based on energy efficiency, to compare subpopulations of buildings, and to identify irregular behavior of buildings across different time-of-use periods. SEEF is an improvement to the energy-intensity method (comparing kWh/sq.ft.): whereas SEEF identifies efficient buildings across the entire spectrum of building sizes, the energy-intensity method showed bias toward smaller buildings. The results of this research are expected to assist researchers and practitioners compare and rank (i.e.,benchmark) buildings more robustly and over a wider range of building types and sizes. Eventually, doing so is expected to result in improved resource allocation in energy-efficiency programs.« less

Biosolar energy generation and harvesting from biomolecule-copolymer hybrid systems

NASA Astrophysics Data System (ADS)

Chu, Bong-Chieh Benjamin

Alternative energy sources have become an increasingly important topic as energy needs outpace supply. Furthermore, as the world moves into the digital age of portable electronics, highly efficient and lightweight energy sources will need to be developed. Current technology, such as lithium ion batteries, provide enough power to run portable electronics for hours or days, but can still allow for improvement in their power density (W/kg). Utilizing energy-transducing membrane proteins, which are by nature highly efficient, it is possible to engineer biological-based energy sources with energy densities far greater than any solid-state systems. Furthermore, solar powered membrane proteins have the added benefit of a virtually unlimited supply of energy. This work has developed protein-polymer hybrid films and nanoscale vesicles for a variety of applications from fuel-cell technology to biological-based photovoltaics. Bacteriorhodopsin (BR), a light-activated proton pump, and Cytochrome C Oxidase (COX), a protein involved in the electron transport chain in mitochondria, were reconstituted into biomimetic triblock copolymer membranes. Block copolymer membranes mimic the amphiphilic nature of a natural lipid bilayer but exhibit greater mechanical stability due to UV-polymerizable endgroups. In BR/COX functionalized nanovesicles, proton gradients generated by the light-activated proton pumping of BR are used to drive COX in reverse to generate electrons, providing a hybrid biologically-active polymer to convert solar energy to chemical energy, and finally to electrical energy. This work has found protein activity in planar membranes through the photoelectric current generation by BR and the proton pumping activity of BR-functionalized polymer membranes deposited onto proton exchange membranes, as well as the coupled functionality of BR and COX through current generation in cyclic voltammetry and direct current measurements. Current switching between light and dark environments of composite BR/COX polymer vesicles show a light-dependent current generation with current changes as high as 10muA. Furthermore, electrode modifications were made using polymer and polymer/carbon nanotube (CNT) coatings as anti-absorbent and conductive anti-absorbent layers for the purpose of a more robust electrode. These findings have shown that biological functionality can be engineered into synthetic polymers to make hybrid devices.

Quantum dynamics in continuum for proton transport II: Variational solvent-solute interface.

PubMed

Chen, Duan; Chen, Zhan; Wei, Guo-Wei

2012-01-01

Proton transport plays an important role in biological energy transduction and sensory systems. Therefore, it has attracted much attention in biological science and biomedical engineering in the past few decades. The present work proposes a multiscale/multiphysics model for the understanding of the molecular mechanism of proton transport in transmembrane proteins involving continuum, atomic, and quantum descriptions, assisted with the evolution, formation, and visualization of membrane channel surfaces. We describe proton dynamics quantum mechanically via a new density functional theory based on the Boltzmann statistics, while implicitly model numerous solvent molecules as a dielectric continuum to reduce the number of degrees of freedom. The density of all other ions in the solvent is assumed to obey the Boltzmann distribution in a dynamic manner. The impact of protein molecular structure and its charge polarization on the proton transport is considered explicitly at the atomic scale. A variational solute-solvent interface is designed to separate the explicit molecule and implicit solvent regions. We formulate a total free-energy functional to put proton kinetic and potential energies, the free energy of all other ions, and the polar and nonpolar energies of the whole system on an equal footing. The variational principle is employed to derive coupled governing equations for the proton transport system. Generalized Laplace-Beltrami equation, generalized Poisson-Boltzmann equation, and generalized Kohn-Sham equation are obtained from the present variational framework. The variational solvent-solute interface is generated and visualized to facilitate the multiscale discrete/continuum/quantum descriptions. Theoretical formulations for the proton density and conductance are constructed based on fundamental laws of physics. A number of mathematical algorithms, including the Dirichlet-to-Neumann mapping, matched interface and boundary method, Gummel iteration, and Krylov space techniques are utilized to implement the proposed model in a computationally efficient manner. The gramicidin A channel is used to validate the performance of the proposed proton transport model and demonstrate the efficiency of the proposed mathematical algorithms. The proton channel conductances are studied over a number of applied voltages and reference concentrations. A comparison with experimental data verifies the present model predictions and confirms the proposed model. Copyright © 2011 John Wiley & Sons, Ltd.

The improving efficiency frontier of inpatient rehabilitation hospitals.

PubMed

Harrison, Jeffrey P; Kirkpatrick, Nicole

2011-01-01

This study uses a linear programming technique called data envelopment analysis to identify changes in the efficiency frontier of inpatient rehabilitation hospitals after implementation of the prospective payment system. The study provides a time series analysis of the efficiency frontier for inpatient rehabilitation hospitals in 2003 immediately after implementation of PPS and then again in 2006. Results indicate that the efficiency frontier of inpatient rehabilitation hospitals increased from 84% in 2003 to 85% in 2006. Similarly, an analysis of slack or inefficiency shows improvements in output efficiency over the study period. This clearly documents that efficiency in the inpatient rehabilitation hospital industry after implementation of PPS is improving. Hospital executives, health care policymakers, taxpayers, and other stakeholders benefit from studies that improve health care efficiency.

A search for far-ultraviolet emissions from the lunar atmosphere.

PubMed

Fastie, W G; Feldman, P D; Henry, R C; Moos, H W; Barth, C A; Thomas, G E; Donahue, T M

1973-11-16

An ultraviolet spectrometer aboard the Apollo 17 orbiting spacecraft attempted to measure ultraviolet emissions from the lunar atmosphere. The only emissions observed were from a transient atmosphere introduced by the lunar landing engine. The absence of atomic hydrogen implies that solar wind protons are converted to hydrogen molecules at the lunar surface.

Proton Exchange Membrane Fuel Cell Engineering Model Powerplant. Test Report: Benchmark Tests in Three Spatial Orientations

NASA Technical Reports Server (NTRS)

Loyselle, Patricia; Prokopius, Kevin

2011-01-01

Proton exchange membrane (PEM) fuel cell technology is the leading candidate to replace the aging alkaline fuel cell technology, currently used on the Shuttle, for future space missions. This test effort marks the final phase of a 5-yr development program that began under the Second Generation Reusable Launch Vehicle (RLV) Program, transitioned into the Next Generation Launch Technologies (NGLT) Program, and continued under Constellation Systems in the Exploration Technology Development Program. Initially, the engineering model (EM) powerplant was evaluated with respect to its performance as compared to acceptance tests carried out at the manufacturer. This was to determine the sensitivity of the powerplant performance to changes in test environment. In addition, a series of tests were performed with the powerplant in the original standard orientation. This report details the continuing EM benchmark test results in three spatial orientations as well as extended duration testing in the mission profile test. The results from these tests verify the applicability of PEM fuel cells for future NASA missions. The specifics of these different tests are described in the following sections.

A new model for the calculation and prediction of solar proton fluences

NASA Technical Reports Server (NTRS)

Feynman, Joan; Gabriel, Stephen B.

1990-01-01

A new predictive engineering model for the energy greater than 10 MeV and greater than 30 MeV solar proton environment at earth is reviewed. The data used are from observations made from 1956 through 1985. In this data set, the distinction between 'ordinary events' and 'anomalously large events' that was required in earlier models disappeared. This permitted the use of statistical analysis methods developed for ordinary events on the entire data set. The greater than 10-MeV fluences with the new model are about twice those expected on the basis of earlier models. At energies greater than 30 MeV, the old and new models agree.

Relativistic neutrons in active galactic nuclei

NASA Technical Reports Server (NTRS)

Sikora, Marek; Begelman, Mitchell C.; Rudak, Bronislaw

1989-01-01

The acceleration of protons to relativistic energies in active galactic nuclei leads to the creation of relativistic neutrons which escape from the central engine. The neutrons decay at distances of up to 1-100 pc, depositing their energies and momenta in situ. Energy deposition by decaying neutrons may inhibit spherical accretion and drive a wind, which could be responsible for the velocity fields in emission-line regions and the outflow of broad absorption line systems. Enhanced pressure in the neutron decay region may also help to confine emission line clouds. A fraction of the relativistic proton energy is radiated in gamma-rays with energies which may be as large as about 100,000 GeV.

The Chandra X-Ray Observatory Radiation Environment Model

NASA Technical Reports Server (NTRS)

Blackwell, W. C.; Minow, Joseph I.; Smith, Shawn; Swift, Wesley R.; ODell, Stephen L.; Cameron, Robert A.

2003-01-01

CRMFLX (Chandra Radiation Model of ion FluX) is an environmental risk mitigation tool for use as a decision aid in planning the operations times for Chandra's Advanced CCD Imaging Spectrometer (ACIS) detector. The accurate prediction of the proton flux environment with energies of 100 - 200 keV is needed in order to protect the ACIS detector against proton degradation. Unfortunately, protons of this energy are abundant in the region of space Chandra must operate, and the on-board Electron, Proton, and Helium Instrument (EPHIN) does not measure proton flux levels of the required energy range. In addition to the concerns arising from the radiation belts, substorm injections of plasma from the magnetotail may increase the protons flux by orders of magnitude in this energy range. The Earth's magnetosphere is a dynamic entity, with the size and location of the magnetopause driven by the highly variable solar wind parameters (number density, velocity, and magnetic field components). Operational times for the telescope must be made weeks in advance, decisions which are complicated by the variability of the environment. CRMFLX is an engineering model developed to address these problems and provides proton flux and fluence statistics for the terrestrial outer magnetosphere, magnetosheath, and solar wind for use in scheduling ACIS operations. CRMFLX implements a number of standard models to predict the bow shock, magnetopause, and plasma sheet boundaries based on the sampling of historical solar wind data sets. Measurements from the GEOTAIL and POLAR spacecraft are used to create the proton flux database. This paper describes the recently released CRMFLX v2 implementation that includes an algorithm that propagates flux from an observation location to other regions of the magnetosphere based on convective ExB and VB-curvature particle drift motions in electric and magnetic fields. This technique has the advantage of more completely filling out the database and makes maximum use of limited data obtained during high Kp periods or in areas of the magnetosphere with poor satellite coverage.

Workshops without Walls: Sharing Scientific Research through Educator Professional Development

NASA Astrophysics Data System (ADS)

Weir, H. M.; Edmonds, J. P.; Hallau, K.; Asplund, S. E.; Cobb, W. H.; Nittler, L. R.; Solomon, S. C.

2013-12-01

Scientific discoveries, large and small, are constantly being made. Whether it is the discovery of a new species or a new comet, it is a challenge to keep up. The media provide some assistance in getting the word out about the discoveries, but not the details or the challenges of the discovery. Professional development is essential for science educators to keep them abreast of the fascinating discoveries that are occurring. The problem is that not every educator has the opportunity to attend a workshop on the most recent findings. NASA's Discovery and New Frontiers Education and Public Outreach program has offered a series of multi-site professional development workshops that have taken place at four physical locations sites: The Johns Hopkins University Applied Physics Laboratory, the Jet Propulsion Laboratory, NASA Johnson Space Center, and the University of Arizona, as well as over the internet. All sites were linked via the Digital Learning Network, on which scientists and educator specialists shared information about their missions and activities. Participants interacted with speakers across the country to learn about Discovery and New Frontiers class missions. The third such annual workshop without walls, 'Challenge of Discovery,' was held on 9 April 2013. Educators from across the country delved into the stories behind some amazing NASA missions, from conception to science results. They learned how scientists, engineers, and mission operators collaborate to meet the challenges of complex missions to assure that science goals are met. As an example of science and engineering coming together, an Instrument Scientist and a Payload Operations Manager from the MESSENGER mission discussed the steps needed to observe Mercury's north polar region, gather data, and finally come to the conclusion that water ice is present in permanently shadowed areas inside polar impact craters. The participating educators were able to work with actual data and experience how the conclusion was reached. This example and others highlight the potential of such workshops to inform and engage educators.

Frontiers in Ecosystem Science: Energizing the Research Agenda

NASA Astrophysics Data System (ADS)

Weathers, K. C.; Groffman, P. M.; VanDolah, E.

2014-12-01

Ecosystem science has a long history as a core component of the discipline of Ecology, and although topics of research have fluctuated over the years, it retains a clear identity and continues to be a vital field. As science is becoming more interdisciplinary, particularly the science of global environmental change, ecosystem scientists are addressing new and important questions at the interface of multiple disciplines. Over the last two years, we organized a series of workshops and discussion groups at multiple scientific-society meetings, including AGU to identify frontiers in ecosystem research. The workshops featured short "soapbox" presentations where speakers highlighted key questions in ecosystem science. The presentations were recorded (video and audio) and subjected to qualitative text analysis for identification of frontier themes, attendees completed surveys, and a dozen additional "key informants" were interviewed about their views about frontiers of the discipline. Our effort produced 253 survey participants; the two largest groups of participants were full professors (24%) and graduate students (24%); no other specific group was > 10%. Formal text analysis of the soapbox presentations produced three major themes; "frontiers," "capacity building," and "barriers to implementation" with four or five sub-themes within each major theme. Key "frontiers" included; 1) better understanding of the drivers of ecosystem change, 2) better understanding of ecosystem process and function, 3) human dimensions of ecosystem science, and 4) problem-solving/applied research. Under "capacity building," key topics included: holistic approaches, cross-disciplinary collaboration, public support for research, data, training, and technology investment. Under "barriers" key topics included: limitations in theoretical thinking, insufficient funding/support, fragmentation across discipline, data access and data synthesis. In-depth interviews with 13 experts validated findings from analysis of soapbox presentations and surveys and also resulted in a conceptual model for understanding disciplinary frontiers.

R-U policy frontiers for health data de-identification

PubMed Central

Heatherly, Raymond; Ding, Xiaofeng; Li, Jiuyong; Malin, Bradley A

2015-01-01

Objective The Health Insurance Portability and Accountability Act Privacy Rule enables healthcare organizations to share de-identified data via two routes. They can either 1) show re-identification risk is small (e.g., via a formal model, such as k-anonymity) with respect to an anticipated recipient or 2) apply a rule-based policy (i.e., Safe Harbor) that enumerates attributes to be altered (e.g., dates to years). The latter is often invoked because it is interpretable, but it fails to tailor protections to the capabilities of the recipient. The paper shows rule-based policies can be mapped to a utility (U) and re-identification risk (R) space, which can be searched for a collection, or frontier, of policies that systematically trade off between these goals. Methods We extend an algorithm to efficiently compose an R-U frontier using a lattice of policy options. Risk is proportional to the number of patients to which a record corresponds, while utility is proportional to similarity of the original and de-identified distribution. We allow our method to search 20 000 rule-based policies (out of 2700) and compare the resulting frontier with k-anonymous solutions and Safe Harbor using the demographics of 10 U.S. states. Results The results demonstrate the rule-based frontier 1) consists, on average, of 5000 policies, 2% of which enable better utility with less risk than Safe Harbor and 2) the policies cover a broader spectrum of utility and risk than k-anonymity frontiers. Conclusions R-U frontiers of de-identification policies can be discovered efficiently, allowing healthcare organizations to tailor protections to anticipated needs and trustworthiness of recipients. PMID:25911674

A new slip stacking RF system for a twofold power upgrade of Fermilab's Accelerator Complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madrak, Robyn

2014-05-15

Fermilab's Accelerator Complex has been recently upgraded, in order to increase the 120 GeV proton beam power on target from about 400 kW to over 700 kW for NOvA and other future intensity frontier experiments. One of the key ingredients of the upgrade is the offloading of some Main Injector synchrotron operations - beam injection and RF manipulation called ''slip stacking'' - to the 8GeV Recycler Ring, which had until recently been used only for low-intensity antiproton storage and cooling. This required construction of two new 53 MHz RF systems for the slip-stacking manipulations. The cavities operate simultaneously at Vmore » peak ≲150 kV, but at slightly different frequencies (Δf=1260 Hz). Their installation was completed in September 2013. This article describes the novel solutions used in the design of the new cavities, their tuning system, and the associated high power RF system. First results showing effective operation of the RF system, beam capture and successful slip-stacking in the Recycler Ring are presented.« less

Superstrong field science

NASA Astrophysics Data System (ADS)

Tajima, T.; Mourou, G.

2002-04-01

Over the past fifteen years we have seen a surge in our ability to produce high intensities, five to six orders of magnitude higher than was possible before. At these intensities, particles, electrons and protons, acquire kinetic energy in the mega-electron-volt range through interaction with intense laser fields. This opens a new age for the laser, the age of nonlinear relativistic optics coupling even with nuclear physics. We suggest a path to reach an extremely high-intensity level 1026-28 W/cm2 in the coming decade, much beyond the current and near future intensity regime 1023 W/cm2, taking advantage of the megajoule laser facilities. Such a laser at extreme high intensity could accelerate particles to frontiers of high energy, tera-electron-volt and peta-electron-volt, and would become a tool of fundamental physics encompassing particle physics, gravitational physics, nonlinear field theory, ultrahigh-pressure physics, astrophysics, and cosmology. Such a laser intensity may also be very beneficial to an alternative, more direct approach of fast ignition in laser fusion. We suggest a new possibility to explore this. .

Optics measurement algorithms and error analysis for the proton energy frontier

NASA Astrophysics Data System (ADS)

Langner, A.; Tomás, R.

2015-03-01

Optics measurement algorithms have been improved in preparation for the commissioning of the LHC at higher energy, i.e., with an increased damage potential. Due to machine protection considerations the higher energy sets tighter limits in the maximum excitation amplitude and the total beam charge, reducing the signal to noise ratio of optics measurements. Furthermore the precision in 2012 (4 TeV) was insufficient to understand beam size measurements and determine interaction point (IP) β -functions (β*). A new, more sophisticated algorithm has been developed which takes into account both the statistical and systematic errors involved in this measurement. This makes it possible to combine more beam position monitor measurements for deriving the optical parameters and demonstrates to significantly improve the accuracy and precision. Measurements from the 2012 run have been reanalyzed which, due to the improved algorithms, result in a significantly higher precision of the derived optical parameters and decreased the average error bars by a factor of three to four. This allowed the calculation of β* values and demonstrated to be fundamental in the understanding of emittance evolution during the energy ramp.

The Coming Revolutions in Particle Physics

ScienceCinema

Quigg, Chris

2017-12-09

Wonderful opportunities await particle physics over the next decade, with new instruments and experiments poised to explore the frontiers of high energy, infinitesimal distances, and exquisite rarity. We look forward to the Large Hadron Collider at CERN to explore the 1-TeV scale (extending efforts at LEP and the Tevatron to unravel the nature of electroweak symmetry breaking) and many initiatives to develop our understanding of the problem of identity: what makes a neutrino a neutrino and a top quark a top quark. We suspect that the detection of proton decay is only a few orders of magnitude away in sensitivity. Astronomical observations should help to tell us what kinds of matter and energy make up the universe. We might even learn to read experiment for clues about the dimensionality of spacetime. If we are inventive enough, we may be able to follow this rich menu with the physics opportunities offered by a linear electron-positron collider and a (muon storage ring) neutrino factory. I expect a remarkable flowering of experimental particle physics, and of theoretical physics that engages with experiment.

Co(salophen)-Catalyzed Aerobic Oxidation of p-Hydroquinone: Mechanism and Implications for Aerobic Oxidation Catalysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anson, Colin W.; Ghosh, Soumya; Hammes-Schiffer, Sharon

2016-03-30

Macrocyclic metal complexes and p-benzoquinones are commonly used as co-catalytic redox mediators in aerobic oxidation reactions. In an effort to gain insight into the mechanism and energetic efficiency of these reactions, we investigated Co(salophen)-catalyzed aerobic oxidation of p-hydroquinone. Kinetic and spectroscopic data suggest that the catalyst resting-state consists of an equilibrium between a CoII(salophen) complex, a CoIII-superoxide adduct, and a hydrogen-bonded adduct between the hydroquinone and the CoIII–O2 species. The kinetic data, together with density functional theory data, suggest that the turnover-limiting step features proton-coupled electron transfer from a semi-hydroquinone species and a CoIII-hydroperoxide intermediate. Additional experimental and computational datamore » suggest that a coordinated H2O2 intermediate oxidizes a second equivalent of hydroquinone. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center, funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. The NSF provided partial support for the EPR instrumentation (NSF CHE-0741901).« less

Computational Study of Breathing-type Processes in Driven, Confined, Granular Alignments

DTIC Science & Technology

2012-04-17

Government of India, Title: : “Newton’s cradle, Fermi, Pasta , Ulam chain & the nonlinear many body frontier,” June 29, 2011 2. Physics Seminar, Indian...Institute of Science, Bangalore, India, Title: “Newton’s cradle, Fermi, Pasta , Ulam chain & the nonlinear many body frontier,” June 30, 2011 3. Physics...Department Colloquium, SUNY Buffalo, Title: “Newton’s cradle, Fermi, Pasta , Ulam chain & the nonlinear many body frontier,” January 20, 2011. 4

Discovery of a Supernova in HST imaging of the MACSJ0717 Frontier Field

NASA Astrophysics Data System (ADS)

Rodney, Steven A.; Lotz, Jennifer; Strolger, Louis-Gregory

2013-10-01

We report the discovery of a supernova (SN) in Hubble Space Telescope (HST) observations centered on the galaxy cluster MACSJ0717. It was discovered in the F814W (i) band of the Advanced Camera for Surveys (ACS), in observations that were collected as part of the ongoing HST Frontier Fields (HFF) program (PI:J.Lotz, HST PID 13498). The FrontierSN ID for this object is SN HFF13Zar (nicknamed "SN Zara").

Transforming Benzophenoxazine Laser Dyes into Chromophores for Dye-Sensitized Solar Cells: A Molecular Engineering Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schröder, Florian A. Y. N.; Cole, Jacqueline M.; Waddell, Paul G.

2015-02-03

The re-functionalization of a series of four well-known industrial laser dyes, based on benzophenoxazine, is explored with the prospect of molecularly engineering new chromophores for dye-sensitized solar cell (DSC) applications. Such engineering is important since a lack of suitable dyes is stifling the progress of DSC technology. The conceptual idea involves making laser dyes DSC-active by chemical modification, while maintaining their key property attributes that are attractive to DSC applications. This molecular engineering follows a step-wise approach. Firstly, molecular structures and optical absorption properties are determined for the parent laser dyes: Cresyl Violet (1); Oxazine 170 (2); Nile Blue Amore » (3), Oxazine 750 (4). These reveal structure-property relationships which define the prerequisites for computational molecular design of DSC dyes; the nature of their molecular architecture (D-π-A) and intramolecular charge transfer. Secondly, new DSC dyes are computationally designed by the in silico addition of a carboxylic acid anchor at various chemical substitution points in the parent laser dyes. A comparison of the resulting frontier molecular orbital energy levels with the conduction band edge of a TiO2 DSC photoanode and the redox potential of two electrolyte options I-/I3- and Co(II/III)tris(bipyridyl) suggests promise for these computationally designed dyes as co-sensitizers for DSC applications.« less

Engineering design of the Regolith X-ray Imaging Spectrometer (REXIS) instrument: an OSIRIS-REx student collaboration

NASA Astrophysics Data System (ADS)

Jones, Michael; Chodas, Mark; Smith, Matthew J.; Masterson, Rebecca A.

2014-07-01

OSIRIS-REx is a NASA New Frontiers mission scheduled for launch in 2016 that will travel to the asteroid Bennu and return a pristine sample of the asteroid to Earth. The REgolith X-ray Imaging Spectrometer (REXIS) is a student collaboration instrument on-board the OSIRIS-REx spacecraft. REXIS is a NASA risk Class D instrument, and its design and development is largely student led. The engineering team consists of MIT graduate and undergraduate students and staff at the MIT Space Systems Laboratory. The primary goal of REXIS is the education of science and engineering students through participation in the development of light hardware. In light, REXIS will contribute to the mission by providing an elemental abundance map of the asteroid and by characterizing Bennu among the known meteorite groups. REXIS is sensitive to X-rays between 0.5 and 7 keV, and uses coded aperture imaging to map the distribution of iron with 50 m spatial resolution. This paper describes the science goals, concept of operations, and overall engineering design of the REXIS instrument. Each subsystem of the instrument is addressed with a high-level description of the design. Critical design elements such as the Thermal Isolation Layer (TIL), radiation cover, coded-aperture mask, and Detector Assembly Mount (DAM) are discussed in further detail.

The Climate Adaptation Frontier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Preston, Benjamin L

2013-01-01

Climate adaptation has emerged as a mainstream risk management strategy for assisting in maintaining socio-ecological systems within the boundaries of a safe operating space. Yet, there are limits to the ability of systems to adapt. Here, we introduce the concept of an adaptation frontier , which is defined as a socio-ecological system s transitional adaptive operating space between safe and unsafe domains. A number of driving forces are responsible for determining the sustainability of systems on the frontier. These include path dependence, adaptation/development deficits, values conflicts and discounting of future loss and damage. The cumulative implications of these driving forcesmore » are highly uncertain. Nevertheless, the fact that a broad range of systems already persist at the edge of their frontiers suggests a high likelihood that some limits will eventually be exceeded. The resulting system transformation is likely to manifest as anticipatory modification of management objectives or loss and damage. These outcomes vary significantly with respect to their ethical implications. Successful navigation of the adaptation frontier will necessitate new paradigms of risk governance to elicit knowledge that encourages reflexive reevaluation of societal values that enable or constrain sustainability.« less

Center for Materials at Irradiation and Mechanical Extremes at LANL (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nastasi, Michael

"Center for Materials at Irradiation and Mechanical Extremes (CMIME) at LANL" was submitted by CMIME to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CMIME, an EFRC directed by Michael Nastasi at Los Alamos National Laboratory is a partnership of scientists from four institutions: LANL (lead), Carnegie Mellon University, the University of Illinois at Urbana-Champaign, and the Massachusetts Institute of Technology. The Office of Basic Energy Sciences in themore » U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Ethos of independence across regions in the United States: the production-adoption model of cultural change.

PubMed

Kitayama, Shinobu; Conway, Lucian Gideon; Pietromonaco, Paula R; Park, Hyekyung; Plaut, Victoria C

2010-09-01

Contemporary U.S. culture has a highly individualistic ethos. Nevertheless, exactly how this ethos was historically fostered remains unanalyzed. A new model of dynamic cultural change maintains that sparsely populated, novel environments that impose major threats to survival, such as the Western frontier in the United States during the 18th and 19th centuries, breed strong values of independence, which in turn guide the production of new practices that encourage self-promotion and focused, competitive work. Faced with few significant threats to survival, residents in traditional areas are likely to seek social prestige by adopting existing practices of other, higher status groups. Because of both the massive economic success of the frontier and the official endorsement of the frontier by the federal government, eastern residents of the United States in the 18th and 19th centuries may have actively adopted the frontier practices of independence, thus incorporating the frontier ethos of independence to form the contemporary U.S. national culture. Available evidence is reviewed, and implications for further research on cultural change are suggested. Copyright 2010 APA, all rights reserved.

Center for Materials at Irradiation and Mechanical Extremes at LANL (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Michael Nastasi (Director, Center for Materials at Irradiation and Mechanical Extremes); CMIME Staff

2017-12-09

'Center for Materials at Irradiation and Mechanical Extremes (CMIME) at LANL' was submitted by CMIME to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CMIME, an EFRC directed by Michael Nastasi at Los Alamos National Laboratory is a partnership of scientists from four institutions: LANL (lead), Carnegia Mellon University, the University of Illinois at Urbana Champaign, and the Massachusetts Institute of Technology. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

TU-EF-304-07: Monte Carlo-Based Inverse Treatment Plan Optimization for Intensity Modulated Proton Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Y; UT Southwestern Medical Center, Dallas, TX; Tian, Z

2015-06-15

Purpose: Intensity-modulated proton therapy (IMPT) is increasingly used in proton therapy. For IMPT optimization, Monte Carlo (MC) is desired for spots dose calculations because of its high accuracy, especially in cases with a high level of heterogeneity. It is also preferred in biological optimization problems due to the capability of computing quantities related to biological effects. However, MC simulation is typically too slow to be used for this purpose. Although GPU-based MC engines have become available, the achieved efficiency is still not ideal. The purpose of this work is to develop a new optimization scheme to include GPU-based MC intomore » IMPT. Methods: A conventional approach using MC in IMPT simply calls the MC dose engine repeatedly for each spot dose calculations. However, this is not the optimal approach, because of the unnecessary computations on some spots that turned out to have very small weights after solving the optimization problem. GPU-memory writing conflict occurring at a small beam size also reduces computational efficiency. To solve these problems, we developed a new framework that iteratively performs MC dose calculations and plan optimizations. At each dose calculation step, the particles were sampled from different spots altogether with Metropolis algorithm, such that the particle number is proportional to the latest optimized spot intensity. Simultaneously transporting particles from multiple spots also mitigated the memory writing conflict problem. Results: We have validated the proposed MC-based optimization schemes in one prostate case. The total computation time of our method was ∼5–6 min on one NVIDIA GPU card, including both spot dose calculation and plan optimization, whereas a conventional method naively using the same GPU-based MC engine were ∼3 times slower. Conclusion: A fast GPU-based MC dose calculation method along with a novel optimization workflow is developed. The high efficiency makes it attractive for clinical usages.« less

FIFE-Jobsub: a grid submission system for intensity frontier experiments at Fermilab

NASA Astrophysics Data System (ADS)

Box, Dennis

2014-06-01

The Fermilab Intensity Frontier Experiments use an integrated submission system known as FIFE-jobsub, part of the FIFE (Fabric for Frontier Experiments) initiative, to submit batch jobs to the Open Science Grid. FIFE-jobsub eases the burden on experimenters by integrating data transfer and site selection details in an easy to use and well-documented format. FIFE-jobsub automates tedious details of maintaining grid proxies for the lifetime of the grid job. Data transfer is handled using the Intensity Frontier Data Handling Client (IFDHC) [1] tool suite, which facilitates selecting the appropriate data transfer method from many possibilities while protecting shared resources from overload. Chaining of job dependencies into Directed Acyclic Graphs (Condor DAGS) is well supported and made easier through the use of input flags and parameters.

The Mid-Cretaceous Frontier Formation near the Moxa Arch, southwestern Wyoming

USGS Publications Warehouse

Mereweather, E.A.; Blackmon, P.D.; Webb, J.C.

1984-01-01

The Frontier Formation in the Green River Basin of Wyoming, Utah, and Colorado, consists of sandstone, siltstone, and shale, and minor conglomerate, coal, and bentonite. These strata were deposited in several marine and nonmarine environments during early Late Cretaceous time. At north-trending outcrops along the eastern edge of the overthrust belt, the Frontier is of Cenomanian, Turonian, and early Coniacian age, and commonly is about 610 m (2,000 ft) thick. The formation in that area conformably overlies the Lower Cretaceous Aspen Shale and is divided into the following members, in ascending order: Chalk Creek, Coalville, Allen Hollow, Oyster Ridge Sandstone, and Dry Hollow. In west-trending outcrops on the northern flank of the Uinta Mountains in Utah, the Frontier is middle and late Turonian, and is about 60 m (200 ft) thick. These strata disconformably overlie the Lower Cretaceous Mowry Shale. In boreholes on the Moxa arch, the upper part of the Frontier is of middle Turonian to early Coniacian age and unconformably overlies the lower part of the formation, which is early Cenomanian at the south end and probably Cenomanian to early Turonian at the north end. The Frontier on the arch thickens northward from less than 100 m (328 ft) to more than 300 m (984 ft) and conformably overlies the Mowry. The marine and nonmarine Frontier near the Uinta Mountains, marine and mnmarine beds in the upper part of the formation on the Moxa arch and the largely nonmarine Dry Hollow Member at the top of the Frontier in the overthrust belt are similar in age. Older strata in the formation, which are represented by the disconformable basal contact of the Frontier near the Uinta Mountains, thicken northward along the Moxa arch and westward between the arch and the overthrust belt. The large changes in thickness of the Frontier in the Green River Basin were caused mainly by differential uplift and truncation of the lower part of the formation during the early to middle Turonian and by the shoreward addition of progressively younger sandstone units at the top of the formation during the late Turonian and early Coniacian. The sandstone in cores of the Frontier, from boreholes on the Moxa arch and the northern plunge of the Rock Springs uplift, consists of very fine grained and fine-grained litharenites and sublitharenites that were deposited in deltaic and shallow-water marine environments. These rocks consist mainly of quartz, chert, rock fragments, mixed-layer illite-smectite, mica-illite, and chlorite. Samples of the sandstone have porosities of 4.7 to 23.0 percent and permeabilities of 0.14 to 6.80 millidarcies, and seem to represent poor to fair reservoir beds for oil and gas. The shale in cores of the Frontier Formation and the overlying basal Hilliard Shale, from the Moxa arch, Rock Springs uplift, and overthrust belt, was deposited in deltaic and offshore-marine environments. Samples of the shale are composed largely of quartz, micaillite, mixed-layer illite-smectite, kaolin, and chlorite. They also contain from 0.27 to 4.42 percent organic carbon, in humic and sapropelic organic matter. Most of the sampled shale units are thermally mature, in terms of oil generation, and a few probably are source rocks for oil and gas.

Liquid Li based neutron source for BNCT and science application.

PubMed

Horiike, H; Murata, I; Iida, T; Yoshihashi, S; Hoashi, E; Kato, I; Hashimoto, N; Kuri, S; Oshiro, S

2015-12-01

Liquid lithium (Li) is a candidate material for a target of intense neutron source, heat transfer medium in space engines and charges stripper. For a medical application of BNCT, epithermal neutrons with least energetic neutrons and γ-ray are required so as to avoid unnecessary doses to a patient. This is enabled by lithium target irradiated by protons at 2.5 MeV range, with utilizing the threshold reaction of (7)Li(p,n)(7)Be at 1.88 MeV. In the system, protons at 2.5 MeV penetrate into Li layer by 0.25 mm with dissipating heat load near the surface. To handle it, thin film flow of high velocity is important for stable operation. For the proton accelerator, electrostatic type of the Schnkel or the tandem is planned to be employed. Neutrons generated at 0.6 MeV are gently moderated to epithermal energy while suppressing accompanying γ-ray minimum by the dedicated moderator assembly. Copyright © 2015 Elsevier Ltd. All rights reserved.

Proton Radiography Peers into Metal Solidification

DOE PAGES

Clarke, Amy J.; Imhoff, Seth D.; Gibbs, Paul J.; ...

2013-06-19

Historically, metals are cut up and polished to see the structure and to infer how processing influences the evolution. We can now peer into a metal during processing without destroying it using proton radiography. Understanding the link between processing and structure is important because structure profoundly affects the properties of engineering materials. Synchrotron x-ray radiography has enabled real-time glimpses into metal solidification. However, x-ray energies favor the examination of small volumes and low density metals. In this study, we use high energy proton radiography for the first time to image a large metal volume (>10,000 mm 3) during melting andmore » solidification. We also show complementary x-ray results from a small volume (<1mm 3), bridging four orders of magnitude. In conclusion, real-time imaging will enable efficient process development and the control of the structure evolution to make materials with intended properties; it will also permit the development of experimentally informed, predictive structure and process models.« less

Peptides at Membrane Surfaces and their Role in the Origin of Life

NASA Technical Reports Server (NTRS)

Pohorille, Andrew; Wilson, Michael A.; DeVincenzi, D. (Technical Monitor)

2002-01-01

All ancestors of contemporary cells (protocells) had to transport ions and organic matter across membranous walls, capture and utilize energy and transduce environmental signals. In modern organisms, all these functions are preformed by membrane proteins. We make the parsimonious assumption that in the protobiological milieu the same functions were carried out by their simple analogs - peptides. This, however, required that simple peptides could self-organize into ordered, functional structures. In a series of detailed, molecular-level computer simulations we demonstrated how this is possible. One example is the peptide (LSLLLSL)3 which forms a trameric bundle capable of transporting protons across membranes. Another example is the transmembrane pore of the influenza M2 protein. This aggregate of four identical alpha-helices, each built of 25 amino acids, forms an efficient and selective voltage-gated proton channel. Our simulations explain the gating mechanism in this channel. The channel can be re-engineered into a simple proton pump.

Identification of a pre-active conformation of a pentameric channel receptor

PubMed Central

Menny, Anaïs; Lefebvre, Solène N; Schmidpeter, Philipp AM; Drège, Emmanuelle; Fourati, Zaineb; Delarue, Marc; Edelstein, Stuart J; Nimigean, Crina M; Joseph, Delphine; Corringer, Pierre-Jean

2017-01-01

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-gated channel GLIC, we engineered multiple fluorescent reporters, each incorporating a bimane and a tryptophan/tyrosine, whose close distance causes fluorescence quenching. We show that proton application causes a global compaction of the extracellular subunit interface, coupled to an outward motion of the M2-M3 loop near the channel gate. These movements are highly similar in lipid vesicles and detergent micelles. These reorganizations are essentially completed within 2 ms and occur without channel opening at low proton concentration, indicating that they report a pre-active intermediate state in the transition pathway toward activation. This provides a template to investigate the gating of eukaryotic neurotransmitter receptors, for which intermediate states also participate in activation. DOI: http://dx.doi.org/10.7554/eLife.23955.001 PMID:28294942

Fort Independence: An Eighteenth-Century Frontier Homesite and Militia Post in South Carolina.

DTIC Science & Technology

1982-12-01

zone was designated Zone 3. The matrix was a moist , black muck with some rocks present, as well as chunks of burned and unburned logs, a 60 x 90cm...area of strong Tory sentiment, Fort ." Independence was important in maintaining South Carolina’s frontier at a critical time. The fort was burned by...Fort Independence was important in maintaining South Carolina’s frontier at a critical time. The fort was burned by Tories in early 1779

Alaska exceptionality hypothesis: Is Alaska wilderness really different?

Treesearch

Gregory Brown

2002-01-01

The common idiom of Alaska as “The Last Frontier” suggests that the relative remoteness and unsettled character of Alaska create a unique Alaskan identity, one that is both a “frontier” and the “last” of its kind. The frontier idiom portrays the place and people of Alaska as exceptional or different from the places and people who reside in the Lower Forty- Eight States...

A fast GPU-based Monte Carlo simulation of proton transport with detailed modeling of nonelastic interactions.

PubMed

Wan Chan Tseung, H; Ma, J; Beltran, C

2015-06-01

Very fast Monte Carlo (MC) simulations of proton transport have been implemented recently on graphics processing units (GPUs). However, these MCs usually use simplified models for nonelastic proton-nucleus interactions. Our primary goal is to build a GPU-based proton transport MC with detailed modeling of elastic and nonelastic proton-nucleus collisions. Using the cuda framework, the authors implemented GPU kernels for the following tasks: (1) simulation of beam spots from our possible scanning nozzle configurations, (2) proton propagation through CT geometry, taking into account nuclear elastic scattering, multiple scattering, and energy loss straggling, (3) modeling of the intranuclear cascade stage of nonelastic interactions when they occur, (4) simulation of nuclear evaporation, and (5) statistical error estimates on the dose. To validate our MC, the authors performed (1) secondary particle yield calculations in proton collisions with therapeutically relevant nuclei, (2) dose calculations in homogeneous phantoms, (3) recalculations of complex head and neck treatment plans from a commercially available treatment planning system, and compared with (GEANT)4.9.6p2/TOPAS. Yields, energy, and angular distributions of secondaries from nonelastic collisions on various nuclei are in good agreement with the (GEANT)4.9.6p2 Bertini and Binary cascade models. The 3D-gamma pass rate at 2%-2 mm for treatment plan simulations is typically 98%. The net computational time on a NVIDIA GTX680 card, including all CPU-GPU data transfers, is ∼ 20 s for 1 × 10(7) proton histories. Our GPU-based MC is the first of its kind to include a detailed nuclear model to handle nonelastic interactions of protons with any nucleus. Dosimetric calculations are in very good agreement with (GEANT)4.9.6p2/TOPAS. Our MC is being integrated into a framework to perform fast routine clinical QA of pencil-beam based treatment plans, and is being used as the dose calculation engine in a clinically applicable MC-based IMPT treatment planning system. The detailed nuclear modeling will allow us to perform very fast linear energy transfer and neutron dose estimates on the GPU.

Free H₂ rotation vs Jahn-Teller constraints in the nonclassical trigonal (TPB)Co-H₂ complex.

PubMed

Gunderson, William A; Suess, Daniel L M; Fong, Henry; Wang, Xiaoping; Hoffmann, Christina M; Cutsail, George E; Peters, Jonas C; Hoffman, Brian M

2014-10-22

Proton exchange within the M-H2 moiety of (TPB)Co(H2) (Co-H2; TPB = B(o-C6H4P(i)Pr2)3) by 2-fold rotation about the M-H2 axis is probed through EPR/ENDOR studies and a neutron diffraction crystal structure. This complex is compared with previously studied (SiP(iPr)3)Fe(H2) (Fe-H2) (SiP(iPr)3 = [Si(o-C6H4P(i)Pr2)3]). The g-values for Co-H2 and Fe-H2 show that both have the Jahn-Teller (JT)-active (2)E ground state (idealized C3 symmetry) with doubly degenerate frontier orbitals, (e)(3) = [|mL ± 2>](3) = [x(2) - y(2), xy](3), but with stronger linear vibronic coupling for Co-H2. The observation of (1)H ENDOR signals from the Co-HD complex, (2)H signals from the Co-D2/HD complexes, but no (1)H signals from the Co-H2 complex establishes that H2 undergoes proton exchange at 2 K through rotation around the Co-H2 axis, which introduces a quantum-statistical (Pauli-principle) requirement that the overall nuclear wave function be antisymmetric to exchange of identical protons (I = 1/2; Fermions), symmetric for identical deuterons (I = 1; Bosons). Analysis of the 1-D rotor problem indicates that Co-H2 exhibits rotor-like behavior in solution because the underlying C3 molecular symmetry combined with H2 exchange creates a dominant 6-fold barrier to H2 rotation. Fe-H2 instead shows H2 localization at 2 K because a dominant 2-fold barrier is introduced by strong Fe(3d)→ H2(σ*) π-backbonding that becomes dependent on the H2 orientation through quadratic JT distortion. ENDOR sensitively probes bonding along the L2-M-E axis (E = Si for Fe-H2; E = B for Co-H2). Notably, the isotropic (1)H/(2)H hyperfine coupling to the diatomic of Co-H2 is nearly 4-fold smaller than for Fe-H2.

Frontier Observatory for Research in Geothermal Energy: Phase 1 Topical Report Fallon, NV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blankenship, Douglas A.; Akerley, John; Blake, Kelly

The Department of Energy (DOE) Frontier Observatory for Research in Geothermal Energy (FORGE) is to be a dedicated site where the subsurface scientific and engineering community can develop, test, and improve technologies and techniques for the creation of cost-effective and sustainable enhanced geothermal systems (EGS) in a controlled, ideal environment. The establishment of FORGE will facilitate development of an understanding of the key mechanisms controlling a successful EGS. Execution of FORGE is occurring in three phases with five distinct sub-phases (1, 2A, 2B, 2C, and 3). This report focuses on Phase 1 activities. During Phase 1, critical technical and logisticalmore » tasks necessary to demonstrate the viability of the Fallon FORGE Project site were completed and the commitment and capability of the Fallon FORGE team to execute FORGE was demonstrated. As part of Phase 1, the Fallon FORGE Team provided an assessment of available relevant data and integrated these geologic and geophysical data to develop a conceptual 3-D geologic model of the proposed test location. Additionally, the team prepared relevant operational plans for full FORGE implementation, provided relevant site data to the science and engineering community, engaged in outreach and communications with interested stakeholders, and performed a review of the environmental and permitting activities needed to allow FORGE to progress through Phase 3. The results of these activities are provided as Appendices to this report. The Fallon FORGE Team is diverse, with deep roots in geothermal science and engineering. The institutions and key personnel that comprise the Fallon FORGE Team provide a breadth of geoscience and geoengineering capabilities, a strong and productive history in geothermal research and applications, and the capability and experience to manage projects with the complexity anticipated for FORGE. Fallon FORGE Team members include the U.S. Navy, Ormat Nevada Inc., Sandia National Laboratories (SNL), Lawrence Berkeley National Laboratory (LBNL), the United States Geological Survey (USGS), the University of Nevada, Reno (UNR), GeothermEx/Schlumberger (GeothelinEx), and Itasca Consulting Group (Itasca). The site owners (through direct land ownership or via applicable permits)—the U.S. Navy and Ormat Nevada Inc.—are deeply committed to expanding the development of geothermal resources and are fully supportive of FORGE operations taking place on their lands.« less

Experiments with bosonic atoms for quantum gas assembly

NASA Astrophysics Data System (ADS)

Brown, Mark; Lin, Yiheng; Lester, Brian; Kaufman, Adam; Ball, Randall; Brossard, Ludovic; Isaev, Leonid; Thiele, Tobias; Lewis-Swan, Robert; Schymik, Kai-Niklas; Rey, Ana Maria; Regal, Cindy

2017-04-01

Quantum gas assembly is a promising platform for preparing and observing neutral atom systems on the single-atom level. We have developed a toolbox that includes ground-state laser cooling, high-fidelity loading techniques, addressable spin control, and dynamic spatial control and coupling of atoms. Already, this platform has enabled us to pursue a number of experiments studying entanglement and interference of pairs of bosonic atoms. We discuss our recent work in probabilistically entangling neutral atoms via interference, measurement, and post-selection as well as our future pursuits of interesting spin-motion dynamics of larger arrays of atoms. This work was supported by the David and Lucile Packard Foundation, National Science Foundation Physics Frontier Centers, and the National Defense Science and Engineering Graduate Fellowships program.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, R.C.; Fujimura, K.; Unseren, M.A.

One of the frontiers in intelligent machine research is the understanding of how constructive cooperation among multiple autonomous agents can be effected. The effort at the Center for Engineering Systems Advanced Research (CESAR)at the Oak Ridge National Laboratory (ORNL) focuses on two problem areas: (1) cooperation by multiple mobile robots in dynamic, incompletely known environments; and (2) cooperating robotic manipulators. Particular emphasis is placed on experimental evaluation of research and developments using the CESAR robot system testbeds, including three mobile robots, and a seven-axis, kinematically redundant mobile manipulator. This paper summarizes initial results of research addressing the decoupling of positionmore » and force control for two manipulators holding a common object, and the path planning for multiple robots in a common workspace. 15 refs., 3 figs.« less

New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy

PubMed Central

2018-01-01

Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsackie viruses, and vaccinia viruses – have been applied as either naturally occurring or engineered vectors. Numerous studies in animal-tumor models have demonstrated substantial tumor regression and prolonged survival rates. Moreover, clinical trials have confirmed good safety profiles and therapeutic efficacy for oncolytic viruses. Most encouragingly, the first cancer gene-therapy drug – Gendicine, based on oncolytic adenovirus type 5 – was approved in China. Likewise, a second-generation oncolytic herpes simplex virus-based drug for the treatment of melanoma has been registered in the US and Europe as talimogene laherparepvec. PMID:29445265

Project X

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holmes, Steve; Alber, Russ; Asner, David

2013-06-23

Particle physics has made enormous progress in understanding the nature of matter and forces at a fundamental level and has unlocked many mysteries of our world. The development of the Standard Model of particle physics has been a magnificent achievement of the field. Many deep and important questions have been answered and yet many mysteries remain. The discovery of neutrino oscillations, discrepancies in some precision measurements of Standard-Model processes, observation of matter-antimatter asymmetry, the evidence for the existence of dark matter and dark energy, all point to new physics beyond the Standard Model. The pivotal developments of our field, includingmore » the latest discovery of the Higgs Boson, have progressed within three interlocking frontiers of research – the Energy, Intensity and Cosmic frontiers – where discoveries and insights in one frontier powerfully advance the other frontiers as well.« less

FIFE-Jobsub: a grid submission system for intensity frontier experiments at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Box, Dennis

2014-01-01

The Fermilab Intensity Frontier Experiments use an integrated submission system known as FIFE-jobsub, part of the FIFE (Fabric for Frontier Experiments) initiative, to submit batch jobs to the Open Science Grid. FIFE-jobsub eases the burden on experimenters by integrating data transfer and site selection details in an easy to use and well-documented format. FIFE-jobsub automates tedious details of maintaining grid proxies for the lifetime of the grid job. Data transfer is handled using the Intensity Frontier Data Handling Client (IFDHC) [1] tool suite, which facilitates selecting the appropriate data transfer method from many possibilities while protecting shared resources from overload.more » Chaining of job dependencies into Directed Acyclic Graphs (Condor DAGS) is well supported and made easier through the use of input flags and parameters.« less

Compendium of Instrumentation Whitepapers on Frontier Physics Needs for Snowmass 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lipton, R.

2013-01-01

Contents of collection of whitepapers include: Operation of Collider Experiments at High Luminosity; Level 1 Track Triggers at HL-LHC; Tracking and Vertex Detectors for a Muon Collider; Triggers for hadron colliders at the energy frontier; ATLAS Upgrade Instrumentation; Instrumentation for the Energy Frontier; Particle Flow Calorimetry for CMS; Noble Liquid Calorimeters; Hadronic dual-readout calorimetry for high energy colliders; Another Detector for the International Linear Collider; e+e- Linear Colliders Detector Requirements and Limitations; Electromagnetic Calorimetry in Project X Experiments The Project X Physics Study; Intensity Frontier Instrumentation; Project X Physics Study Calorimetry Report; Project X Physics Study Tracking Report; The LHCbmore » Upgrade; Neutrino Detectors Working Group Summary; Advanced Water Cherenkov R&D for WATCHMAN; Liquid Argon Time Projection Chamber (LArTPC); Liquid Scintillator Instrumentation for Physics Frontiers; A readout architecture for 100,000 pixel Microwave Kinetic In- ductance Detector array; Instrumentation for New Measurements of the Cosmic Microwave Background polarization; Future Atmospheric and Water Cherenkov ?-ray Detectors; Dark Energy; Can Columnar Recombination Provide Directional Sensitivity in WIMP Search?; Instrumentation Needs for Detection of Ultra-high Energy Neu- trinos; Low Background Materials for Direct Detection of Dark Matter; Physics Motivation for WIMP Dark Matter Directional Detection; Solid Xenon R&D at Fermilab; Ultra High Energy Neutrinos; Instrumentation Frontier: Direct Detection of WIMPs; nEXO detector R&D; Large Arrays of Air Cherenkov Detectors; and Applications of Laser Interferometry in Fundamental Physics Experiments.« less

Emergency medicine: an operations management view.

PubMed

Soremekun, Olan A; Terwiesch, Christian; Pines, Jesse M

2011-12-01

Operations management (OM) is the science of understanding and improving business processes. For the emergency department (ED), OM principles can be used to reduce and alleviate the effects of crowding. A fundamental principle of OM is the waiting time formula, which has clear implications in the ED given that waiting time is fundamental to patient-centered emergency care. The waiting time formula consists of the activity time (how long it takes to complete a process), the utilization rate (the proportion of time a particular resource such a staff is working), and two measures of variation: the variation in patient interarrival times and the variation in patient processing times. Understanding the waiting time formula is important because it presents the fundamental parameters that can be managed to reduce waiting times and length of stay. An additional useful OM principle that is applicable to the ED is the efficient frontier. The efficient frontier compares the performance of EDs with respect to two dimensions: responsiveness (i.e., 1/wait time) and utilization rates. Some EDs may be "on the frontier," maximizing their responsiveness at their given utilization rates. However, most EDs likely have opportunities to move toward the frontier. Increasing capacity is a movement along the frontier and to truly move toward the frontier (i.e., improving responsiveness at a fixed capacity), we articulate three possible options: eliminating waste, reducing variability, or increasing flexibility. When conceptualizing ED crowding interventions, these are the major strategies to consider. © 2011 by the Society for Academic Emergency Medicine.

Dynamical Mass Generation

NASA Astrophysics Data System (ADS)

Bashir, A.; Raya, A.

2006-09-01

Understanding the origin of mass, in particular that of the fermions, is one of the most uncanny problems which lie at the very frontiers of particle physics. Although the celebrated Standard Model accommodates these masses in a gauge invariant fashion, it fails to predict their values. Moreover, the mass thus generated accounts for only a very small percentage of the mass which permeates the visible universe. Most of the observed mass is accounted for by the strong interactions which bind quarks into protons and neutrons. How does that exactly happen in its quantitative details is still an unsolved mystery. Lattice formulation of quantum chromodynamics (QCD) or continuum studies of its Schwinger-Dyson equations (SDEs) are two of the non-perturbative means to try to unravel how quarks, starting from negligible current masses can acquire enormously large constituent masses to account for the observed proton and neutron masses. Analytical studies of SDEs in this context are extremely hard as one has to resort to truncation schemes whose quantitative reliability can be established only after a very careful analysis. Let alone the far more complicated realm of QCD, arriving at reliable truncation schemes in simpler scenarios such as quantum electrodynamics (QED) has also proved to be a hard nut to crack. In the last years, there has been an increasing group of physicists in Mexico which is taking up the challenge of understanding how the dynamical generation of mass can be understood in a reliable way through SDEs of gauge theories in various contexts such as (i) in arbitrary space-time dimensions d as well as d ⩽ 4, (ii) finite temperatures and (ii) in the presence of magnetic fields. In this article, we summarise some of this work.

Reaction mechanism of the ε subunit of E. coli DNA polymerase III: Insights into active site metal coordination and catalytically significant residues

PubMed Central

Cisneros, G. Andrés; Perera, Lalith; Schaaper, Roel M.; Pedersen, Lars C.; London, Robert E.; Pedersen, Lee G.; Darden, Thomas A.

2009-01-01

The 28kDa ε subunit of Escherichia coli DNA polymerase III is the exonucleotidic proofreader responsible for editing polymerase insertion errors. Here, we study the mechanism by which ε carries out the exonuclease activity. We performed quantum mechanics/molecular mechanics calculations on the N–terminal domain containing the exonuclease activity. Both the free–ε and a complex, ε bound to a θ homolog (HOT), were studied. For the ε–HOT complex, Mg2+ or Mn2+ were investigated as the essential divalent metal cofactors, while only Mg2+ was used for free–ε. In all calculations, a water molecule bound to the catalytic metal acts as the nucleophile for the hydrolysis of the phosphate bond. Initially, a direct proton transfer to H162 is observed. Subsequently, the nucleophilic attack takes place, followed by a second proton transfer to E14. Our results show that the reaction catalyzed with Mn2+ is faster than with Mg2+, in agreement with experiment. In addition, the ε–HOT complex shows a slightly lower energy barrier compared to free–ε. In all cases the catalytic metal is observed to be penta–coordinated. Charge and frontier orbital analyses suggest that charge transfer may stabilize the penta–coordination. Energy decomposition analysis to study the contribution of each residue to catalysis suggests that there are several important residues. Among these, H98, D103, D129 and D146 have been implicated in catalysis by mutagenesis studies. Some of these residues were found to be structurally conserved on human TREX1, the exonuclease domains from E. coli DNA–Pol I, and the DNA polymerase of bacteriophage RB69. PMID:19119875

A Ni(II) Bis(diphosphine)-Hydride Complex Containing Proton Relays - Structural Characterization and Electrocatalytic Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, Partha Pratim; Stolley, Ryan M.; Van Der Eide, Edwin F.

The syntheses of the new 1,5-diphenyl-3,7-di(isopropyl)-1,5-diaza-3,7-diphosphacyclooctane ligand, PiPr2NPh2, is reported. The two equivalents of the ligand react with [Ni(CH3CN)6](BF4)2 to form the bis-diphosphine Ni(II)-complex [Ni(PiPr2NPh2)2](BF4)2, which acts as a proton reduction electrocatalyst. In addition to [Ni(PiPr2NPh2)2]2+, we report the syntheses and structural characterization of the Ni(0)-complex Ni(PiPr2NPh2)2, and the Ni(II)-hydride complex [HNi(PiPr2NPh2)2]BF4. The [HNi(PiPr2NPh2)2]BF4 complex represents the first Ni(II)-hydride in the [Ni(PR2NR'2)2]2+ family of compounds to be isolated and structurally characterized. In addition to the experimental data, the mechanism of electrocatalysis facilitated by [Ni(PiPr2NPh2)2]2+ is analyzed using linear free energy relationships recently established for the [Ni(PR2NR'2)2]2+ family. We thank Dr.more » Aaron Appel, Dr. Simone Raugei and Dr. Eric Wiedner for helpful discussions. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Mass spectrometry was provided at W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the Department of Energy’s office of Biological and Environmental Research located at Pacific Northwest National Laboratory. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

Pesticide use and biodiversity conservation in the Amazonian agricultural frontier.

PubMed

Schiesari, Luis; Waichman, Andrea; Brock, Theo; Adams, Cristina; Grillitsch, Britta

2013-06-05

Agricultural frontiers are dynamic environments characterized by the conversion of native habitats to agriculture. Because they are currently concentrated in diverse tropical habitats, agricultural frontiers are areas where the largest number of species is exposed to hazardous land management practices, including pesticide use. Focusing on the Amazonian frontier, we show that producers have varying access to resources, knowledge, control and reward mechanisms to improve land management practices. With poor education and no technical support, pesticide use by smallholders sharply deviated from agronomical recommendations, tending to overutilization of hazardous compounds. By contrast, with higher levels of technical expertise and resources, and aiming at more restrictive markets, large-scale producers adhered more closely to technical recommendations and even voluntarily replaced more hazardous compounds. However, the ecological footprint increased significantly over time because of increased dosage or because formulations that are less toxic to humans may be more toxic to other biodiversity. Frontier regions appear to be unique in terms of the conflicts between production and conservation, and the necessary pesticide risk management and risk reduction can only be achieved through responsibility-sharing by diverse stakeholders, including governmental and intergovernmental organizations, NGOs, financial institutions, pesticide and agricultural industries, producers, academia and consumers.

Evolution of grid-wide access to database resident information in ATLAS using Frontier

NASA Astrophysics Data System (ADS)

Barberis, D.; Bujor, F.; de Stefano, J.; Dewhurst, A. L.; Dykstra, D.; Front, D.; Gallas, E.; Gamboa, C. F.; Luehring, F.; Walker, R.

2012-12-01

The ATLAS experiment deployed Frontier technology worldwide during the initial year of LHC collision data taking to enable user analysis jobs running on the Worldwide LHC Computing Grid to access database resident data. Since that time, the deployment model has evolved to optimize resources, improve performance, and streamline maintenance of Frontier and related infrastructure. In this presentation we focus on the specific changes in the deployment and improvements undertaken, such as the optimization of cache and launchpad location, the use of RPMs for more uniform deployment of underlying Frontier related components, improvements in monitoring, optimization of fail-over, and an increasing use of a centrally managed database containing site specific information (for configuration of services and monitoring). In addition, analysis of Frontier logs has allowed us a deeper understanding of problematic queries and understanding of use cases. Use of the system has grown beyond user analysis and subsystem specific tasks such as calibration and alignment, extending into production processing areas, such as initial reconstruction and trigger reprocessing. With a more robust and tuned system, we are better equipped to satisfy the still growing number of diverse clients and the demands of increasingly sophisticated processing and analysis.

Modeling stochastic frontier based on vine copulas

NASA Astrophysics Data System (ADS)

Constantino, Michel; Candido, Osvaldo; Tabak, Benjamin M.; da Costa, Reginaldo Brito

2017-11-01

This article models a production function and analyzes the technical efficiency of listed companies in the United States, Germany and England between 2005 and 2012 based on the vine copula approach. Traditional estimates of the stochastic frontier assume that data is multivariate normally distributed and there is no source of asymmetry. The proposed method based on vine copulas allow us to explore different types of asymmetry and multivariate distribution. Using data on product, capital and labor, we measure the relative efficiency of the vine production function and estimate the coefficient used in the stochastic frontier literature for comparison purposes. This production vine copula predicts the value added by firms with given capital and labor in a probabilistic way. It thereby stands in sharp contrast to the production function, where the output of firms is completely deterministic. The results show that, on average, S&P500 companies are more efficient than companies listed in England and Germany, which presented similar average efficiency coefficients. For comparative purposes, the traditional stochastic frontier was estimated and the results showed discrepancies between the coefficients obtained by the application of the two methods, traditional and frontier-vine, opening new paths of non-linear research.

Moving from Petroleum to Plants to Energize our World (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCann, Maureen; Yohe, Sara

"Moving from Petroleum to Plants to Energize our World" was submitted by the Center for Direct Catalytic Conversion of Biomass to Biofuels (C3Bio) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. C3Bio, an EFRC directed by Maureen McCann at Purdue University is a partnership between five institutions: Purdue (lead), National Renewable Energy Laboratory, Northeastern University, University of California Santa Barbara and the University of Tennessee. The Office ofmore » Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Enabling Energy Efficiency (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coltrin, Mike; Simmons, Jerry

"Enabling Energy Efficiency" was submitted by the EFRC for Solid-State Lighting Science (SSLS) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. SSLS is directed by Mike Coltrin (Acting) and Jerry Simmons at Sandia National Laboratories, and is a partnership of scientists from eight institutions: Sandia National Laboratories (lead); California Institute of Technology; Los Alamos National Laboratoryl; University of New Mexico; Northwestern University; Philips Lumileds Lighting; University of Californiamore » Merced and Santa Barbara. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

CABS: Green Energy for Our Nation's Future (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

"CABS: Green Energy for our Nation's Future" was submitted by the Center for Advanced Biofuel Systems (CABS) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CABS, an EFRC directed by Jan Jaworski at the Donald Danforth Plant Science Center is a partnership of scientists from five institutions: Donald Danforth Plant Science Center (lead), Michigan State University, the University of Nebraska, New Mexico Consortium/LANL, and Washington State University. Themore » Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Enabling Energy Efficiency (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Coltrin, Mike (Acting Director, EFRC for Solid State Lighting Science); Simmons, Jerry; SSLS Staff

2017-12-09

'Enabling Energy Efficiency' was submitted by the EFRC for Solid-State Lighting Science (SSLS) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. SSLS is directed by Mike Coltrin (Acting) and Jerry Simmons at Sandia National Laboratories, and is a partnership of scientists from eight institutions: Sandia National Laboratories (lead); California Institute of Technology; Los Alamos National Laboratory; University of Massachusetts, Lowell; University of New Mexico; Northwestern University; Philips Lumileds Lighting; and Rensselaer Polytechnic Institute. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Moving from Petroleum to Plants to Energize our World (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

McCann, Maureen (Director, Center for Direct Catalytic Conversion of Biomass to Biofuels); C3Bio Staff

2017-12-09

'Moving from Petroleum to Plants to Energize our World' was submitted by the Center for Direct Catalytic Conversion of Biomass to Biofuels (C3Bio) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. C3Bio, an EFRC directed by Maureen McCann at Purdue University is a partnership between five institutions: Purdue (lead), Argonne National Laboratory, National Renewable Energy Laboratory, Northeastern University, and the University of Tennessee. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Pesticide use and biodiversity conservation in the Amazonian agricultural frontier

PubMed Central

Schiesari, Luis; Waichman, Andrea; Brock, Theo; Adams, Cristina; Grillitsch, Britta

2013-01-01

Agricultural frontiers are dynamic environments characterized by the conversion of native habitats to agriculture. Because they are currently concentrated in diverse tropical habitats, agricultural frontiers are areas where the largest number of species is exposed to hazardous land management practices, including pesticide use. Focusing on the Amazonian frontier, we show that producers have varying access to resources, knowledge, control and reward mechanisms to improve land management practices. With poor education and no technical support, pesticide use by smallholders sharply deviated from agronomical recommendations, tending to overutilization of hazardous compounds. By contrast, with higher levels of technical expertise and resources, and aiming at more restrictive markets, large-scale producers adhered more closely to technical recommendations and even voluntarily replaced more hazardous compounds. However, the ecological footprint increased significantly over time because of increased dosage or because formulations that are less toxic to humans may be more toxic to other biodiversity. Frontier regions appear to be unique in terms of the conflicts between production and conservation, and the necessary pesticide risk management and risk reduction can only be achieved through responsibility-sharing by diverse stakeholders, including governmental and intergovernmental organizations, NGOs, financial institutions, pesticide and agricultural industries, producers, academia and consumers. PMID:23610177

LUNA: Nuclear Astrophysics Deep Underground

NASA Astrophysics Data System (ADS)

Broggini, Carlo; Bemmerer, Daniel; Guglielmetti, Alessandra; Menegazzo, Roberto

2010-11-01

Nuclear astrophysics strives for a comprehensive picture of the nuclear reactions responsible for synthesizing chemical elements and for powering the stellar evolution engine. Deep underground in the Gran Sasso National Laboratory, the cross sections of the key reactions of the proton-proton chain and of the carbon-nitrogen-oxygen cycle have been measured right down to the energies of astrophysical interest. The salient features of underground nuclear astrophysics are summarized here. We review the main results obtained by LUNA during the past 20 years and discuss their influence on our understanding of the properties of the neutrino, the Sun, and the universe itself. Future directions of underground nuclear astrophysics toward the study both of helium and carbon burning and of stellar neutron sources in stars are outlined.

Proton therapy for prostate cancer online: patient education or marketing?

PubMed

Sadowski, Daniel J; Ellimoottil, Chandy S; Tejwani, Ajay; Gorbonos, Alex

2013-12-01

Proton therapy (PT) for prostate cancer is an expensive treatment with limited evidence of benefit over conventional radiotherapy. We sought to study whether online information on PT for prostate cancer was balanced and whether the website source influenced the content presented. We applied a systematic search process to identify 270 weblinks associated with PT for prostate cancer, categorized the websites by source, and filtered the results to 50 websites using predetermined criteria. We then used a customized version of the DISCERN instrument, a validated tool for assessing the quality of consumer health information, to evaluate the remaining websites for balance of content and description of risks, benefits and uncertainty. Depending on the search engine and key word used, proton center websites (PCWs) made up 10%-47% of the first 30 encountered links. In comparison, websites from academic and nonacademic medical centers without ownership stake in proton centers appeared much less frequently as a search result (0%-3%). PCWs scored lower on DISCERN questions compared to other sources for being balanced/unbiased (p < 0.001), mentioning areas of uncertainty (p < 0.001), and describing risks of PT (p < 0.001). PCWs scored higher for describing the benefits of treatment (p = 0.003). Patients should be aware that online information regarding PT for prostate cancer may represent marketing by proton centers rather than comprehensive and unbiased patient education. An awareness of these results will also better prepare clinicians to address the potential biases of patients with prostate cancer who search the Internet for health information.

Interpreting New Data from the High Energy Frontier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thaler, Jesse

2016-09-26

This is the final technical report for DOE grant DE-SC0006389, "Interpreting New Data from the High Energy Frontier", describing research accomplishments by the PI in the field of theoretical high energy physics.

Numerical Investigation on Sensitivity of Liquid Jet Breakup to Physical Fuel Properties with Experimental Comparison

NASA Astrophysics Data System (ADS)

Kim, Dokyun; Bravo, Luis; Matusik, Katarzyna; Duke, Daniel; Kastengren, Alan; Swantek, Andy; Powell, Christopher; Ham, Frank

2016-11-01

One of the major concerns in modern direct injection engines is the sensitivity of engine performance to fuel characteristics. Recent works have shown that even slight differences in fuel properties can cause significant changes in efficiency and emission of an engine. Since the combustion process is very sensitive to the fuel/air mixture formation resulting from disintegration of liquid jet, the precise assessment of fuel sensitivity on liquid jet atomization process is required first to study the impact of different fuels on the combustion. In the present study, the breaking process of a liquid jet from a diesel injector injecting into a quiescent gas chamber is investigated numerically and experimentally for different liquid fuels (n-dodecane, iso-octane, CAT A2 and C3). The unsplit geometric Volume-of-Fluid method is employed to capture the phase interface in Large-eddy simulations and results are compared against the radiography measurement from Argonne National Lab including jet penetration, liquid mass distribution and volume fraction. The breakup characteristics will be shown for different fuels as well as droplet PDF statistics to demonstrate the influences of the physical properties on the primary atomization of liquid jet. Supported by HPCMP FRONTIER award, US DOD, Office of the Army.

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

PubMed Central

Choi, Ji Sun; Mahadik, Bhushan P.; Harley, Brendan A. C.

2016-01-01

Hematopoietic stem cells (HSCs) play a crucial role in the generation of the body’s blood and immune cells. This process takes place primarily in the bone marrow in specialized ‘niche’ microenvironments, which provide signals responsible for maintaining a balance between HSC quiescence, self-renewal, and lineage specification required for life-long hematopoiesis. While our understanding of these signaling mechanisms continues to improve, our ability to engineer them in vitro for the expansion of clinically relevant HSC populations is still lacking. In this review, we focus on development of biomaterials-based culture platforms for in vitro study of interactions between HSCs and their local microenvironment. The tools and techniques used for both examining HSC-niche interactions as well as applying these findings towards controlled HSC expansion or directed differentiation in 2D and 3D platforms are discussed. These novel techniques hold the potential to push the existing boundaries of HSC cultures towards high-throughput, real-time, and single-cell level biomimetic approaches that enable a more nuanced understanding of HSC regulation and function. Their application in conjunction with innovative biomaterial platforms can pave the way for engineering artificial bone marrow niches for clinical applications as well as elucidating the pathology of blood-related cancers and disorders. PMID:26356030

Lambda Red-mediated mutagenesis and efficient large scale affinity purification of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).

PubMed

Pohl, Thomas; Uhlmann, Mareike; Kaufenstein, Miriam; Friedrich, Thorsten

2007-09-18

The proton-pumping NADH:ubiquinone oxidoreductase, the respiratory complex I, couples the transfer of electrons from NADH to ubiquinone with the translocation of protons across the membrane. The Escherichia coli complex I consists of 13 different subunits named NuoA-N (from NADH:ubiquinone oxidoreductase), that are coded by the genes of the nuo-operon. Genetic manipulation of the operon is difficult due to its enormous size. The enzymatic activity of variants is obscured by an alternative NADH dehydrogenase, and purification of the variants is hampered by their instability. To overcome these problems the entire E. coli nuo-operon was cloned and placed under control of the l-arabinose inducible promoter ParaBAD. The exposed N-terminus of subunit NuoF was chosen for engineering the complex with a hexahistidine-tag by lambda-Red-mediated recombineering. Overproduction of the complex from this construct in a strain which is devoid of any membrane-bound NADH dehydrogenase led to the assembly of a catalytically active complex causing the entire NADH oxidase activity of the cytoplasmic membranes. After solubilization with dodecyl maltoside the engineered complex binds to a Ni2+-iminodiacetic acid matrix allowing the purification of approximately 11 mg of complex I from 25 g of cells. The preparation is pure and monodisperse and comprises all known subunits and cofactors. It contains more lipids than earlier preparations due to the gentle and fast purification procedure. After reconstitution in proteoliposomes it couples the electron transfer with proton translocation in an inhibitor sensitive manner, thus meeting all prerequisites for structural and functional studies.

Application of Fuzzy Logic in Oral Cancer Risk Assessment

PubMed Central

SCROBOTĂ, Ioana; BĂCIUȚ, Grigore; FILIP, Adriana Gabriela; TODOR, Bianca; BLAGA, Florin; BĂCIUȚ, Mihaela Felicia

2017-01-01

Background: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. Methods: Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012–2014). Results: We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors’ values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. Conclusion: The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders. PMID:28560191

Application of Fuzzy Logic in Oral Cancer Risk Assessment.

PubMed

Scrobotă, Ioana; Băciuț, Grigore; Filip, Adriana Gabriela; Todor, Bianca; Blaga, Florin; Băciuț, Mihaela Felicia

2017-05-01

The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012-2014). We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors' values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders.

Underlying thermodynamics of pH-dependent allostery.

PubMed

Di Russo, Natali V; Martí, Marcelo A; Roitberg, Adrian E

2014-11-13

Understanding the effects of coupling protein protonation and conformational states is critical to the development of drugs targeting pH sensors and to the rational engineering of pH switches. In this work, we address this issue by performing a comprehensive study of the pH-regulated switch from the closed to the open conformation in nitrophorin 4 (NP4) that determines its pH-dependent activity. Our calculations show that D30 is the only amino acid that has two significantly different pKas in the open and closed conformations, confirming its critical role in regulating pH-dependent behavior. In addition, we describe the free-energy landscape of the conformational change as a function of pH, obtaining accurate estimations of free-energy barriers and equilibrium constants using different methods. The underlying thermodynamic model of the switch workings suggests the possibility of tuning the observed pKa only through the conformational equilibria, keeping the same conformation-specific pKas, as evidenced by the proposed K125L mutant. Moreover, coupling between the protonation and conformational equilibria results in efficient regulation and pH-sensing around physiological pH values only for some combinations of protonation and conformational equilibrium constants, placing constraints on their possible values and leaving a narrow space for protein molecular evolution. The calculations and analysis presented here are of general applicability and provide a guide as to how more complex systems can be studied, offering insight into how pH-regulated allostery works of great value for designing drugs that target pH sensors and for rational engineering of pH switches beyond the common histidine trigger.

Spot scanning proton therapy plan assessment: design and development of a dose verification application for use in routine clinical practice

NASA Astrophysics Data System (ADS)

Augustine, Kurt E.; Walsh, Timothy J.; Beltran, Chris J.; Stoker, Joshua B.; Mundy, Daniel W.; Parry, Mark D.; Bues, Martin; Fatyga, Mirek

2016-04-01

The use of radiation therapy for the treatment of cancer has been carried out clinically since the late 1800's. Early on however, it was discovered that a radiation dose sufficient to destroy cancer cells can also cause severe injury to surrounding healthy tissue. Radiation oncologists continually strive to find the perfect balance between a dose high enough to destroy the cancer and one that avoids damage to healthy organs. Spot scanning or "pencil beam" proton radiotherapy offers another option to improve on this. Unlike traditional photon therapy, proton beams stop in the target tissue, thus better sparing all organs beyond the targeted tumor. In addition, the beams are far narrower and thus can be more precisely "painted" onto the tumor, avoiding exposure to surrounding healthy tissue. To safely treat patients with proton beam radiotherapy, dose verification should be carried out for each plan prior to treatment. Proton dose verification systems are not currently commercially available so the Department of Radiation Oncology at the Mayo Clinic developed its own, called DOSeCHECK, which offers two distinct dose simulation methods: GPU-based Monte Carlo and CPU-based analytical. The three major components of the system include the web-based user interface, the Linux-based dose verification simulation engines, and the supporting services and components. The architecture integrates multiple applications, libraries, platforms, programming languages, and communication protocols and was successfully deployed in time for Mayo Clinic's first proton beam therapy patient. Having a simple, efficient application for dose verification greatly reduces staff workload and provides additional quality assurance, ultimately improving patient safety.

An Ever Present Danger: A Concise History of British Military Operations on the North-West Frontier, 1849-1947 (Occasional Paper, Number 33)

DTIC Science & Technology

2010-06-01

belong almost exclusively to the trans-border Pashtun tribes. As Thomas H. Johnson and M. Chris Mason have pointed out; “The implica- 2 tions of the...Moreman, The Army in India and the Development of Frontier Warfare, 1849–1947 (London: Macmillan Press Ltd., 1998), 240. 4. Thomas H. Johnson and M...time they confronted the Pashtun tribes of the North-West Frontier. 14 Notes 1. Barbara D. Metcalf and Thomas R. Metcalf, A Concise History

Microfabrication of biocompatible hydrogels by proton beam writing

NASA Astrophysics Data System (ADS)

Nagasawa, Naotsugu; Kimura, Atsushi; Idesaki, Akira; Yamada, Naoto; Koka, Masashi; Satoh, Takahiro; Ishii, Yasuyuki; Taguchi, Mitsumasa

2017-10-01

Functionalization of biocompatible materials is expected to be widely applied in biomedical engineering and regenerative medicine fields. Hydrogel has been expected as a biocompatible scaffold which support to keep an organ shape during cell multiplying in regenerative medicine. Therefore, it is important to understanding a surface microstructure (minute shape, depth of flute) and a chemical characteristic of the hydrogel affecting the cell culture. Here, we investigate the microfabrication of biocompatible polymeric materials, such as the water-soluble polysaccharide derivatives hydroxypropyl cellulose and carboxymethyl cellulose, by use of proton beam writing (PBW). These polymeric materials were dissolved thoroughly in pure water using a planetary centrifugal mixer, and a sample sheet (1 mm thick) was formed on polyethylene terephthalate (PET) film. Crosslinking to form hydrogels was induced using a 3.0 MeV focused proton beam from the single-ended accelerator at Takasaki Ion Accelerators for Advanced Radiation Application. The aqueous samples were horizontally irradiated with the proton beam through the PET cover film, and then rinsed with deionized water. Microstructured hydrogels were obtained on the PET film using the PBW technique without toxic crosslinking reagents. Cell adhesion and proliferation on the microfabricated biocompatible hydrogels were investigated. Microfabrication of HPC and CMC by the use of PBW is expected to produce new biocompatible materials that can be applied in biological and medical applications.

Self-assembled block copolymer-nanoparticle hybrids: interplay between enthalpy and entropy.

PubMed

Sarkar, Biswajit; Alexandridis, Paschalis

2012-11-13

The dispersion of nanoparticles in ordered block copolymer nanostructures can provide control over particle location and orientation, and pave the way for engineered nanomaterials that have enhanced mechanical, electrical, or optical properties. Fundamental questions pertaining to the role of enthalpic and entropic particle-polymer interactions remain open and motivate the present work. We consider here a system of 10.6 nm silica nanoparticles (NPs) dispersed in ordered cylinders formed by hydrated poly(ethylene oxide)-poly(propylene oxide) block copolymers (Pluronic P105: EO(37)PO(56)EO(37)). Protonation of silica was used to vary the NP-polymer enthalpic interactions, while polar organic solvents (glycerol, DMSO, ethanol, and DMF) were used to modulate the NP-polymer entropic interactions. The introduction of deprotonated NPs in the place of an equal mass of water did not affect the lattice parameter of the PEO-PPO-PEO block copolymer hexagonal lyotropic liquid crystalline structures. However, the dispersion of protonated NPs led to an increase in the lattice parameter, which was attributed to stronger NP-polymer hydrogen bonding (enthalpic) interactions. Dispersion of protonated NPs into cylindrical structures formed by Pluronic P105 in 80/20 water/organic solvents does not influence the lattice parameter, different from the case of protonated NP in plain water. Organic solvents appear to screen the NP-polymer hydrogen bonding interactions.

TU-C-17A-08: Improving IMRT Planning and Reducing Inter-Planner Variability Using the Stochastic Frontier Method: Validation Based On Clinical and Simulated Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gagne, MC; Archambault, L; CHU de Quebec, Quebec, Quebec

2014-06-15

Purpose: Intensity modulated radiation therapy always requires compromises between PTV coverage and organs at risk (OAR) sparing. We previously developed metrics that correlate doses to OAR to specific patients’ morphology using stochastic frontier analysis (SFA). Here, we aim to examine the validity of this approach using a large set of realistically simulated dosimetric and geometric data. Methods: SFA describes a set of treatment plans as an asymmetric distribution with respect to a frontier defining optimal plans. Eighty head and neck IMRT plans were used to establish a metric predicting the mean dose to parotids as a function of simple geometricmore » parameters. A database of 140 parotids was used as a basis distribution to simulate physically plausible data of geometry and dose. Distributions comprising between 20 and 5000 were simulated and the SFA was applied to obtain new frontiers, which were compared to the original frontier. Results: It was possible to simulate distributions consistent with the original dataset. Below 160 organs, the SFA could not always describe distributions as asymmetric: a few cases showed a Gaussian or half-Gaussian distribution. In order to converge to a stable solution, the number of organs in a distribution must ideally be above 100, but in many cases stable parameters could be achieved with as low as 60 samples of organ data. Mean RMS value of the error of new frontiers was significantly reduced when additional organs are used. Conclusion: The number of organs in a distribution showed to have an impact on the effectiveness of the model. It is always possible to obtain a frontier, but if the number of organs in the distribution is small (< 160), it may not represent de lowest dose achievable. These results will be used to determine number of cases necessary to adapt the model to other organs.« less

NASA Astrophysics Education and Public Outreach: Engaging Educators and Students in Exploring the Cosmic Frontier

NASA Astrophysics Data System (ADS)

Lawton, Brandon L.; Eisenhamer, Bonnie; Smith, Denise Anne; Jirdeh, Hussein; Summers, Frank; Darnell, John T.; Ryer, Holly

2015-08-01

NASA’s Frontier Fields is an ambitious three-year Great Observatories program that will expand our understanding of galaxy formation and evolution in the early universe. The program includes six deep-field observations of strong-lensing galaxy clusters that will be taken in parallel with six deep “blank fields.” The observations allow astronomers to look deeper into the universe than ever before, and potentially uncover galaxies that are as much as 100 times fainter than what the telescopes can typically observe. The Frontier Fields science program is ideal for informing audiences about scientific advances and topics in STEM. The study of galaxy properties, statistics, optics, and Einstein’s theory of general relativity naturally leverages off of the science returns of the Frontier Fields program. As a result, the Space Telescope Science Institute’s Office of Public Outreach (OPO) has initiated an E/PO project to follow the progress of the Frontier Fields.For over two decades, the Hubble E/PO program has sought to bring the wonders of the universe to the education community, the youth, and the public, and engage audiences in the adventure of scientific discovery. Program components include standards-based curriculum-support materials, exhibits and exhibit components, professional development workshops, and direct interactions with scientists. We are also leveraging our new social media strategy to bring the science program to the public in the form of an ongoing blog. The main underpinnings of the program’s infrastructure are scientist-educator development teams, partnerships, and an embedded program evaluation component. OPO is leveraging this existing infrastructure to bring the Frontier Fields science program to the education community and the public in a cost-effective way.This talk features the goals and current status of the Frontier Fields E/PO program, with a particular emphasis on our education goals and achievements. We also highlight OPO’s strategies and infrastructure which allows for the quick delivery of groundbreaking science to the education community and public.

Securing the Internet frontier.

PubMed

Morrissey, J

1996-10-21

Just as in the Wild West, security strategies are being mobilized for the untamed Internet frontier. Technology developed by settlers from the banking and merchandising industries is being retooled for healthcare, where security-conscious industries see a big market opportunity.

40 CFR 81.328 - Nebraska.

Code of Federal Regulations, 2014 CFR

2014-07-01

... County Dundy County Fillmore County Franklin County Frontier County Furnas County Gage County Garden... Fillmore County Franklin County Frontier County Furnas County Gage County Garden County Garfield County.../Attainment. Garden County Unclassifiable/Attainment. Garfield County Unclassifiable/Attainment. Gosper County...

The BUFFALO HST Survey

NASA Astrophysics Data System (ADS)

Steinhardt, Charles; Jauzac, Mathilde; Capak, Peter; Koekemoer, Anton; Oesch, Pascal; Richard, Johan; Sharon, Keren q.; BUFFALO

2018-01-01

Beyond Ultra-deep Frontier Fields And Legacy Observations (BUFFALO) is an astronomical survey built around the six Hubble Space Telescope (HST) Frontier Fields clusters designed to learn about early galactic assembly and clustering and prepare targets for observations with the James Webb Space Telescope. BUFFALO will place significant new constraints on how and when the most massive and luminous galaxies in the universe formed and how early galaxy formation is linked to dark matter assembly. The same data will also probe the temperature and cross section of dark matter in the massive Frontier Fields galaxy clusters, and tell us how the dark matter, cluster gas, and dynamics of the clusters influence the galaxies in and around them. These studies are possible because the Spitzer Space Telescope, Chandra X-ray Observatory, XMM-Newton, and ground based telescopes have already invested heavily in deep observations around the Frontier Fields, so that the addition of HST observations can yield significant new results.

An Efficient, Noniterative Method of Identifying the Cost-Effectiveness Frontier.

PubMed

Suen, Sze-chuan; Goldhaber-Fiebert, Jeremy D

2016-01-01

Cost-effectiveness analysis aims to identify treatments and policies that maximize benefits subject to resource constraints. However, the conventional process of identifying the efficient frontier (i.e., the set of potentially cost-effective options) can be algorithmically inefficient, especially when considering a policy problem with many alternative options or when performing an extensive suite of sensitivity analyses for which the efficient frontier must be found for each. Here, we describe an alternative one-pass algorithm that is conceptually simple, easier to implement, and potentially faster for situations that challenge the conventional approach. Our algorithm accomplishes this by exploiting the relationship between the net monetary benefit and the cost-effectiveness plane. To facilitate further evaluation and use of this approach, we also provide scripts in R and Matlab that implement our method and can be used to identify efficient frontiers for any decision problem. © The Author(s) 2015.

An Efficient, Non-iterative Method of Identifying the Cost-Effectiveness Frontier

PubMed Central

Suen, Sze-chuan; Goldhaber-Fiebert, Jeremy D.

2015-01-01

Cost-effectiveness analysis aims to identify treatments and policies that maximize benefits subject to resource constraints. However, the conventional process of identifying the efficient frontier (i.e., the set of potentially cost-effective options) can be algorithmically inefficient, especially when considering a policy problem with many alternative options or when performing an extensive suite of sensitivity analyses for which the efficient frontier must be found for each. Here, we describe an alternative one-pass algorithm that is conceptually simple, easier to implement, and potentially faster for situations that challenge the conventional approach. Our algorithm accomplishes this by exploiting the relationship between the net monetary benefit and the cost-effectiveness plane. To facilitate further evaluation and use of this approach, we additionally provide scripts in R and Matlab that implement our method and can be used to identify efficient frontiers for any decision problem. PMID:25926282

WE-E-BRB-02: Implementation of Pencil Beam Scanning (PBS) Proton Therapy Treatment for Liver Patient

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, L.

Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed.more » Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian.; H. Li, Na.« less

WE-E-BRB-01: Personalized Motion Management Strategies for Pencil Beam Scanning Proton Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, X.

Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed.more » Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian.; H. Li, Na.« less

WE-E-BRB-00: Motion Management for Pencil Beam Scanning Proton Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed.more » Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian.; H. Li, Na.« less

WE-E-BRB-03: Implementation of PBS Proton Therapy Treatment for Free Breathing Lung Cancer Patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, H.

Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed.more » Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian.; H. Li, Na.« less

SU-E-T-523: On the Radiobiological Impact of Lateral Scatter in Proton Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heuvel, F Van den; Deruysscher, D

2014-06-01

Introduction: In proton therapy, justified concern has been voiced with respect to an increased efficiency in cell kill at the distal end of the Bragg peak. This coupled with range uncertainty is a counter indication to use the Bragg peak to define the border of a treated volume with a critical organ. An alternative is to use the lateral edge of the proton beam, obtaining more robust plans. We investigate the spectral and biological effects of the lateral scatter . Methods: A general purpose Monte Carlo simulation engine (MCNPX 2.7c) installed on a Scientific Linux cluster, calculated the dose depositionmore » spectrum of protons, knock on electrons and generated neutrons for a proton beam with maximal kinetic energy of 200MeV. Around the beam at different positions in the beam direction the spectrum is calculated in concentric rings of thickness 1cm. The deposited dose is converted to a double strand break map using an analytical expression.based on micro dosimetric calculations using a phenomenological Monte Carlo code (MCDS). A strict version of RBE is defined as the ratio of generation of double strand breaks in the different modalities. To generate the reference a Varian linac was modelled in MCNPX and the generated electron dose deposition spectrum was used . Results: On a pristine point source 200MeV beam the RBE before the Bragg peak was of the order of 1.1, increasing to 1.7 right behind the Bragg peak. When using a physically more realistic beam of 10cm diameter the effect was smaller. Both the lateral dose and RBE increased with increasing beam depth, generating a dose deposition with mixed biological effect. Conclusions: The dose deposition in proton beams need to be carefully examined because the biological effect will be different depending on the treatment geometry. Deeply penetrating proton beams generate more biologically effective lateral scatter.« less

FTIR spectroscopic study on individual amino acid residues in the proton pumping process of bacteriorhodopsin

NASA Astrophysics Data System (ADS)

Liu, Xiaomei

1998-05-01

My thesis project has concentrated on clarifying the role of individual amino acids such as tyrosine, arginine and threonine in the active proton transferring process of Bacteriorhodopsin(bR). BR is a protein found in the purple membrane of Halobacteria salinarium. The main function of bR is to transfer a proton from the interior side of the cell to the external medium upon illumination by visible light. BR belongs to a family of retinal- containing membrane proteins which includes rhodopsin, a visual receptor found in the eye, and sensory rhodopsin I, a light receptor for phototaxis found in H. salinarium. Complete understanding of the proton transferring mechanism of bR can help explain the energy transduction and active ion transport in biological systems. This information also provides insight into other members of the retinal-containing protein family. To study the behavior of a single amino acid in a protein which consists of 248 amino acids, I employed the Fourier transform infrared (FTIR) difference spectroscopy technique. This was combined with the recently developed genetic engineering method of site directed isotope labeling (SDIL). As complementary work, I also characterized the vibrational properties of individual amino acids in various environments. Because of the high resolution and sensitivity of FTIR difference spectroscopy, along with the ability of SDIL to detect structural changes at the single amino acid level, we are able to determine changes in the structure of specific amino acids at different steps in bR photocycle. My research results provide strong evidence for a proton pump model. This model predicts the participation of tyrosine 185 and one or more threonines in a hydrogen bonded chain which can transfer proton across the membrane. My data also suggest a more accurate model for the proton release step which involves arginine 82.

Innovative Educational Aerospace Research at the Northeast High School Space Research Center

NASA Technical Reports Server (NTRS)

Luyet, Audra; Matarazzo, Anthony; Folta, David

1997-01-01

Northeast High Magnet School of Philadelphia, Pennsylvania is a proud sponsor of the Space Research Center (SPARC). SPARC, a model program of the Medical, Engineering, and Aerospace Magnet school, provides talented students the capability to successfully exercise full simulations of NASA manned missions. These simulations included low-Earth Shuttle missions and Apollo lunar missions in the past, and will focus on a planetary mission to Mars this year. At the end of each scholastic year, a simulated mission, lasting between one and eight days, is performed involving 75 students as specialists in seven teams The groups are comprised of Flight Management, Spacecraft Communications (SatCom), Computer Networking, Spacecraft Design and Engineering, Electronics, Rocketry, Robotics, and Medical teams in either the mission operations center or onboard the spacecraft. Software development activities are also required in support of these simulations The objective of this paper is to present the accomplishments, technology innovations, interactions, and an overview of SPARC with an emphasis on how the program's educational activities parallel NASA mission support and how this education is preparing student for the space frontier.

G-DYN Multibody Dynamics Engine

NASA Technical Reports Server (NTRS)

Acikmese, Behcet; Blackmore, James C.; Broderick, Daniel

2011-01-01

G-DYN is a multi-body dynamic simulation software engine that automatically assembles and integrates equations of motion for arbitrarily connected multibody dynamic systems. The algorithm behind G-DYN is based on a primal-dual formulation of the dynamics that captures the position and velocity vectors (primal variables) of each body and the interaction forces (dual variables) between bodies, which are particularly useful for control and estimation analysis and synthesis. It also takes full advantage of the spare matrix structure resulting from the system dynamics to numerically integrate the equations of motion efficiently. Furthermore, the dynamic model for each body can easily be replaced without re-deriving the overall equations of motion, and the assembly of the equations of motion is done automatically. G-DYN proved an essential software tool in the simulation of spacecraft systems used for small celestial body surface sampling, specifically in simulating touch-and-go (TAG) maneuvers of a robotic sampling system from a comet and asteroid. It is used extensively in validating mission concepts for small body sample return, such as Comet Odyssey and Galahad New Frontiers proposals.

Experimental verification of acoustic pseudospin multipoles in a symmetry-broken snowflakelike topological insulator

NASA Astrophysics Data System (ADS)

Zhang, Zhiwang; Tian, Ye; Cheng, Ying; Liu, Xiaojun; Christensen, Johan

2017-12-01

Topologically protected wave engineering in artificially structured media resides at the frontier of ongoing metamaterials research, which is inspired by quantum mechanics. Acoustic analogs of electronic topological insulators have recently led to a wealth of new opportunities in manipulating sound propagation by means of robust edge mode excitations through analogies drawn to exotic quantum states. A variety of artificial acoustic systems hosting topological edge states have been proposed analogous to the quantum Hall effect, topological insulators, and Floquet topological insulators in electronic systems. However, those systems were characterized by a fixed geometry and a very narrow frequency response, which severely hinders the exploration and design of useful applications. Here we establish acoustic multipolar pseudospin states as an engineering degree of freedom in time-reversal invariant flow-free phononic crystals and develop reconfigurable topological insulators through rotation of their meta-atoms and reshaping of the metamolecules. Specifically, we show how rotation forms man-made snowflakelike molecules, whose topological phase mimics pseudospin-down (pseudospin-up) dipolar and quadrupolar states, which are responsible for a plethora of robust edge confined properties and topological controlled refraction disobeying Snell's law.

A culture of technical knowledge: Professionalizing science and engineering education in late-nineteenth century America

NASA Astrophysics Data System (ADS)

Nienkamp, Paul

This manuscript examines the intellectual, cultural, and practical approaches to science and engineering education as a part of the land-grant college movement in the Midwest between the 1850s and early 1900s. These land-grant institutions began and grew within unique frontier societies that both cherished self-reliance and diligently worked to make themselves part of the larger national experience. College administrators and professors encountered rapidly changing public expectations, regional needs, and employment requirements. They recognized a dire need for technically skilled men and women who could quickly adapt to changes in equipment and processes, and implement advances in scientific knowledge in American homes, fields, and factories. Charged with educating the "industrial classes in the several pursuits and professions in life," land-grant college supporters and professors sought out the most modern and innovative instructional methods. Combining the humanities, sciences, and practical skills that they believed uniquely suited student needs, these pioneering educators formulated new curricula and training programs that advanced both the knowledge and the social standing of America's agricultural and mechanical working classes.

Durability and Life of Ceramic Matrix Composites in Combustion Environment

NASA Technical Reports Server (NTRS)

Tewari, Surendra

1997-01-01

It is now generally recognized that the next frontier in the commercial air travel will be achieved by an optimum combination of the concepts being used for the air and space transports. It will depend upon the new engines specifically designed to meet the demanding strength, temperature, environment and economy requirements. The successful development of an advanced propulsion system for a 21st Century High Speed Civil Transport will require key advances in the combustor system. Minimizing nitrous oxide (NO(x)) emission is critical, since the deleterious interaction within the ozone layer would occur at the proposed vehicle cruise level of about 75,000 feet. In order to achieve the low NOx levels an efficient combustor operating at controlled equivalence ratios and high combustion temperatures are required. This requires a combustor, whose one portion will be operating in an oxidizing environment while the other portion will operate in a reducing environment. This rather unusual requirement has introduced considerable challenge to the materials scientists and engineers, the development of material systems capable of long-life at high temperatures (up to 3000 F) in an oxidizing and/or reducing environment.

Earth-to-Orbit Laser Launch Simulation for a Lightcraft Technology Demonstrator

NASA Astrophysics Data System (ADS)

Richard, J. C.; Morales, C.; Smith, W. L.; Myrabo, L. N.

2006-05-01

Optimized laser launch trajectories have been developed for a 1.4 m diameter, 120 kg (empty mass) Lightcraft Technology Demonstrator (LTD). The lightcraft's combined-cycle airbreathing/rocket engine is designed for single-stage-to-orbit flights with a mass ratio of 2 propelled by a 100 MW class ground-based laser built on a 3 km mountain peak. Once in orbit, the vehicle becomes an autonomous micro-satellite. Two types of trajectories were simulated with the SORT (Simulation and Optimization of Rocket Trajectories) software package: a) direct GBL boost to orbit, and b) GBL boost aided by laser relay satellite. Several new subroutines were constructed for SORT to input engine performance (as a function of Mach number and altitude), vehicle aerodynamics, guidance algorithms, and mass history. A new guidance/steering option required the lightcraft to always point at the GBL or laser relay satellite. SORT iterates on trajectory parameters to optimize vehicle performance, achieve a desired criteria, or constrain the solution to avoid some specific limit. The predicted laser-boost performance for the LTD is undoubtedly revolutionary, and SORT simulations have helped to define this new frontier.

The Frontier Fields: Survey Design and Initial Results

NASA Astrophysics Data System (ADS)

Lotz, J. M.; Koekemoer, A.; Coe, D.; Grogin, N.; Capak, P.; Mack, J.; Anderson, J.; Avila, R.; Barker, E. A.; Borncamp, D.; Brammer, G.; Durbin, M.; Gunning, H.; Hilbert, B.; Jenkner, H.; Khandrika, H.; Levay, Z.; Lucas, R. A.; MacKenty, J.; Ogaz, S.; Porterfield, B.; Reid, N.; Robberto, M.; Royle, P.; Smith, L. J.; Storrie-Lombardi, L. J.; Sunnquist, B.; Surace, J.; Taylor, D. C.; Williams, R.; Bullock, J.; Dickinson, M.; Finkelstein, S.; Natarajan, P.; Richard, J.; Robertson, B.; Tumlinson, J.; Zitrin, A.; Flanagan, K.; Sembach, K.; Soifer, B. T.; Mountain, M.

2017-03-01

What are the faintest distant galaxies we can see with the Hubble Space Telescope (HST) now, before the launch of the James Webb Space Telescope? This is the challenge taken up by the Frontier Fields, a Director’s discretionary time campaign with HST and the Spitzer Space Telescope to see deeper into the universe than ever before. The Frontier Fields combines the power of HST and Spitzer with the natural gravitational telescopes of massive high-magnification clusters of galaxies to produce the deepest observations of clusters and their lensed galaxies ever obtained. Six clusters—Abell 2744, MACSJ0416.1-2403, MACSJ0717.5+3745, MACSJ1149.5+2223, Abell S1063, and Abell 370—have been targeted by the HST ACS/WFC and WFC3/IR cameras with coordinated parallel fields for over 840 HST orbits. The parallel fields are the second-deepest observations thus far by HST with 5σ point-source depths of ˜29th ABmag. Galaxies behind the clusters experience typical magnification factors of a few, with small regions magnified by factors of 10-100. Therefore, the Frontier Field cluster HST images achieve intrinsic depths of ˜30-33 mag over very small volumes. Spitzer has obtained over 1000 hr of Director’s discretionary imaging of the Frontier Field cluster and parallels in IRAC 3.6 and 4.5 μm bands to 5σ point-source depths of ˜26.5, 26.0 ABmag. We demonstrate the exceptional sensitivity of the HST Frontier Field images to faint high-redshift galaxies, and review the initial results related to the primary science goals.

International Space Station (ISS)

NASA Image and Video Library

2001-06-08

Astronaut Susan J. Helms, Expedition Two flight engineer, mounts a video camera onto a bracket in the Russian Zarya or Functional Cargo Block (FGB) of the International Space Station (ISS). Launched by a Russian Proton rocket from the Baikonu Cosmodrome on November 20, 1998, the Unites States-funded and Russian-built Zarya was the first element of the ISS, followed by the U.S. Unity Node.

Radiation Effects in 3D Integrated SOl SRAM Circuits

DTIC Science & Technology

2011-08-23

Because of the front-to- hack capacitive coupling, significant device parametric shifts can be observed unless the BOX has been engineered to...8. - l.E-12 .,..--------------, .. J5 ;::.. 5 63-MeV Protons · Tier1 • ner2 ner3 -c a • ’i 1.E-13 ----·· -----·-- ~ . = . i§ • • g • f L_

The National Spallation Neutron Source Target Station.

NASA Astrophysics Data System (ADS)

Gabriel, T. A.

1997-05-01

The technologies that are being utilized to design and build a state-of-the-art high powered (>= 1 MW), short pulsed (<= 1 μsec), and reliable spallation neutron source target station are discussed. The protons which directly and indirectly produce the neutrons will be obtained from a 1 GeV proton accelerator composed of an ion gun, rfq, linac, and storage ring. Many scientific and technical disciplines are required to produce a successful target station. These disciplines include engineering, remote handling, neutronics, materials, thermal hydraulics, shock analysis, etc. In the areas of engineering and remote handling special emphasis is being given to rapid and efficient assembly and disassembly of critical parts of the target station. In the neutronics area, emphasis is being given to neutron yield and pulse optimization from the moderators, and heating and activation rates throughout the station. Development of structural materials to withstand aggressive radiation environments and that are compatible with other materials is also an important area. Thermal hydraulics and shock analysis are being closely studied since large amounts of energy are being deposited in small volumes in relatively short time periods (< 1 μsec). These areas will be expanded upon in the paper.

Press Room

Science.gov Websites

Science at Fermilab Fermilab and the Higgs Boson Frontiers of Particle Physics Experiments & Projects Frontiers of Particle Physics Benefits to Society Contacting Fermilab General Contact Information Email -12 Programs Lederman Science Center Saturday Morning Physics Cooperative Education Program

Sustainability Frontiers

ERIC Educational Resources Information Center

Selby, David

2010-01-01

This article introduces Sustainability Frontiers, a newly formed, international, not-for-profit alliance of sustainability and global educators dedicated to challenging and laying bare the assumptions, exposing the blind spots, and transgressing the boundaries of mainstream understandings of sustainability-related education. Among the orthodoxies…

[The Probabilistic Efficiency Frontier: A Value Assessment of Treatment Options in Hepatitis C].

PubMed

Mühlbacher, Axel C; Sadler, Andrew

2017-06-19

Background The German Institute for Quality and Efficiency in Health Care (IQWiG) recommends the concept of the efficiency frontier to assess health care interventions. The efficiency frontier supports regulatory decisions on reimbursement prices for the appropriate allocation of health care resources. Until today this cost-benefit assessment framework has only been applied on the basis of individual patient-relevant endpoints. This contradicts the reality of a multi-dimensional patient benefit. Objective The objective of this study was to illustrate the operationalization of multi-dimensional benefit considering the uncertainty in clinical effects and preference data in order to calculate the efficiency of different treatment options for hepatitis C (HCV). This case study shows how methodological challenges could be overcome in order to use the efficiency frontier for economic analysis and health care decision-making. Method The operationalization of patient benefit was carried out on several patient-relevant endpoints. Preference data from a discrete choice experiment (DCE) study and clinical data based on clinical trials, which reflected the patient and the clinical perspective, respectively, were used for the aggregation of an overall benefit score. A probabilistic efficiency frontier was constructed in a Monte Carlo simulation with 10000 random draws. Patient-relevant endpoints were modeled with a beta distribution and preference data with a normal distribution. The assessment of overall benefit and costs provided information about the adequacy of the treatment prices. The parameter uncertainty was illustrated by the price-acceptability-curve and the net monetary benefit. Results Based on the clinical and preference data in Germany, the interferon-free treatment options proved to be efficient for the current price level. The interferon-free therapies of the latest generation achieved a positive net cost-benefit. Within the decision model, these therapies showed a maximum overall benefit. Due to their high additional benefit and approved prices, the therapies lie above of the extrapolated efficiency frontier, which suggests that these options have efficient reimbursement prices. Considering uncertainty, even a higher price would have resulted in a positive cost-benefit ratio. Conclusion IQWiG's efficiency frontier was used to assess the value of different treatment options in HCV. This study demonstrates that the probabilistic efficiency frontier, price-acceptability-curve and the net monetary benefit can contribute essential information to reimbursement decisions and price negotiations. © Georg Thieme Verlag KG Stuttgart · New York.

Geant4 calculations for space radiation shielding material Al2O3

NASA Astrophysics Data System (ADS)

Capali, Veli; Acar Yesil, Tolga; Kaya, Gokhan; Kaplan, Abdullah; Yavuz, Mustafa; Tilki, Tahir

2015-07-01

Aluminium Oxide, Al2O3 is the most widely used material in the engineering applications. It is significant aluminium metal, because of its hardness and as a refractory material owing to its high melting point. This material has several engineering applications in diverse fields such as, ballistic armour systems, wear components, electrical and electronic substrates, automotive parts, components for electric industry and aero-engine. As well, it is used as a dosimeter for radiation protection and therapy applications for its optically stimulated luminescence properties. In this study, stopping powers and penetrating distances have been calculated for the alpha, proton, electron and gamma particles in space radiation shielding material Al2O3 for incident energies 1 keV - 1 GeV using GEANT4 calculation code.

WE-D-17A-06: Optically Stimulated Luminescence Detectors as ‘LET-Meters’ in Proton Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Granville, D; Sahoo, N; Sawakuchi, GO

Purpose: To demonstrate and evaluate the potential of optically stimulated luminescence (OSL) detectors (OSLDs) for measurements of linear energy transfer (LET) in therapeutic proton beams. Methods: Batches of Al2O2:C OSLDs were irradiated with an absorbed dose of 0.2 Gy in un-modulated proton beams of varying LET (0.67 keV/μm to 2.58 keV/μm). The OSLDs were read using continuous wave (CW-OSL) and pulsed (P-OSL) stimulation modes. We parameterized and calibrated three characteristics of the OSL signals as functions of LET: CW-OSL curve shape, P-OSL curve shape and the ratio of the two OSL emission band intensities (ultraviolet/blue ratio). Calibration curves were createdmore » for each of these characteristics to describe their behaviors as functions of LET. The true LET values were determined using a validated Monte Carlo model of the proton therapy nozzle used to irradiate the OSLDs. We then irradiated batches of OSLDs with an absorbed dose of 0.2 Gy at various depths in two modulated proton beams (140 MeV, 4 cm wide spread-out Bragg peak (SOBP) and 250 MeV, 10 cm wide SOBP). The LET values were calculated using the OSL response and the calibration curves. Finally, measured LET values were compared to the true values determined using Monte Carlo simulations. Results: The CW-OSL curve shape, P-OSL curve shape and the ultraviolet/blue-ratio provided proton LET estimates within 12.4%, 5.7% and 30.9% of the true values, respectively. Conclusion: We have demonstrated that LET can be measured within 5.7% using Al2O3:C OSLDs in the therapeutic proton beams used in this investigation. From a single OSLD readout, it is possible to measure both the absorbed dose and LET. This has potential future applications in proton therapy quality assurance, particularly for treatment plans based on optimization of LET distributions. This research was partially supported by the Natural Sciences and Engineering Research Council of Canada.« less

Intelligent ePR system for evidence-based research in radiotherapy: proton therapy for prostate cancer.

PubMed

Le, Anh H; Liu, Brent; Schulte, Reinhard; Huang, H K

2011-11-01

Proton therapy (PT) utilizes high energy particle proton beam to kill cancer cells at the target region for target cancer therapy. Due to the physical properties of the proton beam, PT delivers dose with higher precision and no exit dose compared to conventional radiotherapy. In PT, patient data are distributed among multiple systems, a hindrance to research on efficacy and effectiveness. A data mining method and a treatment plan navigator utilizing the infrastructure and data repository of a PT electronic patient record (ePR) was developed to minimize radiation toxicity and improve outcomes in prostate cancer treatment. MATERIALS/METHOD(S): The workflow of a proton therapy treatment in a radiation oncology department was reviewed, and a clinical data model and data flow were designed. A prototype PT ePR system with DICOM compliance was developed to manage prostate cancer patient images, treatment plans, and related clinical data. The ePR system consists of four main components: (1) Data Gateway; (2) ePR Server; (3) Decision Support Tools; and (4) Visualization and Display Tools. Decision support and visualization tools are currently developed based on DICOM images, DICOM-RT and DICOM-RT-ION objects data from prostate cancer patients treated with hypofractionation protocol proton therapy were used for evaluating ePR system effectiveness. Each patient data set includes a set of computed tomography (CT) DICOM images and four DICOM-RT and RT-ION objects. In addition, clinical outcomes data collected from PT cases were included to establish a knowledge base for outcomes analysis. A data mining search engine and an intelligent treatment plan navigator (ITPN) were developed and integrated with the ePR system. Evaluation was based on a data set of 39 PT patients and a hypothetical patient. The ePR system was able to facilitate the proton therapy workflow. The PT ePR system was feasible for prostate cancer patient treated with hypofractionation protocol in proton therapy. This ePR system improves efficiency in data collection and integration to facilitate outcomes analysis.

Basic Solar Energy Research in Japan (2011 EFRC Forum)

ScienceCinema

Domen, Kazunari

2018-02-06

Kazunari Domen, Chemical System Engineering Professor at the University of Tokyo, was the second speaker in the May 26, 2011 EFRC Forum session, "Global Perspectives on Frontiers in Energy Research." In his presentation, Professor Domen talked about basic solar energy research in Japan. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

Nutrition Frontiers E-Newsletter | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group, Division of Cancer Prevention at NCI issues a quarterly electronic newsletter, Nutrition Frontiers, that highlights emerging evidence linking diet to cancer prevention and showcases recent findings about who will likely benefit most from dietary change. |

Frontier Fields: Bringing the Distant Universe into View

NASA Astrophysics Data System (ADS)

Eisenhamer, Bonnie; Lawton, Brandon L.; Summers, Frank; Ryer, Holly

2014-06-01

The Frontier Fields is a multi-cycle program of six deep-field observations of strong-lensing galaxy clusters that will be taken in parallel with six deep “blank fields.” The three-year long collaborative program centers on observations from NASA’s Great Observatories, who will team up to look deeper into the universe than ever before, and potentially uncover galaxies that are as much as 100 times fainter than what the telescopes can typically see. Because of the unprecedented views of the universe that will be achieved, the Frontier Fields science program is ideal for informing audiences about scientific advances and topics in STEM. For example, the program provides an opportunity to look back on the history of deep field observations and how they changed (and continue to change) astronomy, while exploring the ways astronomers approach big science problems. As a result, the Space Telescope Science Institute’s Office of Public Outreach has initiated an education and public outreach (E/PO) project to follow the progress of the Frontier Fields program - providing a behind-the-scenes perspective of this observing initiative. This poster will highlight the goals of the Frontier Fields E/PO project and the cost-effective approach being used to bring the program’s results to both the public and educational audiences.

Migration to the Maya Biosphere Reserve, Guatemala: Why place matters.

PubMed

Carr, David L

2008-01-01

Virtually all migration research examines international migration or urbanization. Yet understudied rural migrants are of critical concern for environmental conservation and rural sustainable development. Despite the fact that a relatively small number of all migrants settle remote rural frontiers, these are the agents responsible for perhaps most of the tropical deforestation on the planet. Further, rural migrants are among the most destitute people worldwide in terms of economic and human development. While a host of research has investigated deforestation resulting from frontier migration, and a modest literature has emerged on frontier development, this article explores the necessary antecedent to tropical deforestation and poverty along agricultural frontiers: out-migration from origin areas. The data come from a 2000 survey with community leaders and key informants in 16 municipios of migrant origin to the Maya Biosphere Reserve (MBR), Petén, Guatemala. A common denominator among communities of migration origin to the Petén frontier was unequal resource access, usually land. Nevertheless, the factors driving resource scarcity were widely variable. Land degradation, land consolidation, and population growth prevailed in some communities but not in others. Despite similar exposure to community and regional level push factors, most people in the sampled communities did not out-migrate, suggesting that any one or combination of factors is not necessarily sufficient for out-migration.

Solar Cells from Plastics? Mission Possible at the PHaSE Energy Research Center, UMass Amherst (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Russell, Thomas P; Lahti, Paul M. (PHaSE - Polymer-Based Materials for Harvesting Solar Energy); PHaSE Staff

2017-12-09

'Solar Cells from Plastics? Mission Possible at the PHaSE Energy Research Center, UMass Amherst' was submitted by the Polymer-Based Materials for Harvesting Solar Energy (PHaSE) EFRC to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PHaSE, an EFRC co-directed by Thomas P. Russell and Paul M. Lahti at the University of Massachusetts, Amherst, is a partnership of scientists from six institutions: UMass (lead), Oak Ridge National Laboratory, Pennyslvania State University, Rensselaer Polytechnic Institute, and the University of Pittsburgh. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

Solar Cells from Plastics? Mission Possible at the PHaSE Energy Research Center, UMass Amherst (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pentzer, Emily

"Solar Cells from Plastics? Mission Possible at the PHaSE Energy Research Center, UMass Amherst" was submitted by the Polymer-Based Materials for Harvesting Solar Energy (PHaSE) EFRC to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PHaSE, an EFRC co-directed by Thomas P. Russell and Paul M. Lahti at the University of Massachusetts, Amherst, is a partnership of scientists from six institutions: UMass (lead), Oak Ridge National Laboratory, Pennsylvania Statemore » University, Rensselaer Polytechnic Institute, and the University of Pittsburgh. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

Migration to the Maya Biosphere Reserve, Guatemala: Why place matters

PubMed Central

Carr, David L.

2009-01-01

Virtually all migration research examines international migration or urbanization. Yet understudied rural migrants are of critical concern for environmental conservation and rural sustainable development. Despite the fact that a relatively small number of all migrants settle remote rural frontiers, these are the agents responsible for perhaps most of the tropical deforestation on the planet. Further, rural migrants are among the most destitute people worldwide in terms of economic and human development. While a host of research has investigated deforestation resulting from frontier migration, and a modest literature has emerged on frontier development, this article explores the necessary antecedent to tropical deforestation and poverty along agricultural frontiers: out-migration from origin areas. The data come from a 2000 survey with community leaders and key informants in 16 municipios of migrant origin to the Maya Biosphere Reserve (MBR), Petén, Guatemala. A common denominator among communities of migration origin to the Petén frontier was unequal resource access, usually land. Nevertheless, the factors driving resource scarcity were widely variable. Land degradation, land consolidation, and population growth prevailed in some communities but not in others. Despite similar exposure to community and regional level push factors, most people in the sampled communities did not out-migrate, suggesting that any one or combination of factors is not necessarily sufficient for out-migration. PMID:19657470

Enabling Intensity and Energy Frontier Science with a Muon Accelerator Facility in the U.S.: A White Paper Submitted to the 2013 U.S. Community Summer Study of the Division of Particles and Fields of the American Physical Society

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delahaye, J-P.; Ankenbrandt, C.; Bogacz, A.

2013-08-01

A staged approach towards muon based facilities for Intensity and Energy Frontier science, building upon existing and proposed facilities at Fermilab, is presented. At each stage, a facility exploring new physics also provides an R&D platform to validate the technology needed for subsequent stages. The envisioned program begins with nuSTORM, a sensitive sterile neutrino search which also provides precision neutrino cross-section measurements while developing the technology of using and cooling muons. A staged Neutrino Factory based upon Project X, sending beams towards the Sanford Underground Research Facility (SURF), which will house the LBNE detector, could follow for detailed exploration ofmore » neutrino properties at the Intensity Frontier, while also establishing the technology of using intense bunched muon beams. The complex could then evolve towards Muon Colliders, starting at 126 GeV with measurements of the Higgs resonance to sub-MeV precision, and continuing to multi-TeV colliders for the exploration of physics beyond the Standard Model at the Energy Frontier. An Appendix addresses specific questions raised by the Lepton Colliders subgroup of the CSS2013 Frontier Capabilities Study Group.« less

New interplanetary proton fluence model

NASA Technical Reports Server (NTRS)

Feynman, Joan; Armstrong, T. P.; Dao-Gibner, L.; Silverman, S.

1990-01-01

A new predictive engineering model for the interplanetary fluence of protons with above 10 MeV and above 30 MeV is described. The data set used is a combination of observations made from the earth's surface and from above the atmosphere between 1956 and 1963 and observations made from spacecraft in the vicinity of earth between 1963 and 1985. The data cover a time period three times as long as the period used in earlier models. With the use of this data set the distinction between 'ordinary proton events' and 'anomalously large events' made in earlier work disappears. This permitted the use of statistical analysis methods developed for 'ordinary events' on the entire data set. The greater than 10 MeV fluences at 1 AU calculated with the new model are about twice those expected on the basis of models now in use. At energies above 30 MeV, the old and new models agree. In contrast to earlier models, the results do not depend critically on the fluence from any one event and are independent of sunspot number. Mission probability curves derived from the fluence distribution are presented.

Long-lived neutral-kaon flux measurement for the KOTO experiment

DOE PAGES

Masuda, T.; Ahn, J. K.; Banno, S.; ...

2016-01-24

The KOTO(K 0 at Tokai) experiment aims to observe the CP-violating rare decay K L → π 0νν¯ over bar by using a long-lived neutral-kaon beam produced by the 30 GeV proton beam at the Japan Proton Accelerator Research Complex. The K L flux is an essential parameter for the measurement of the branching fraction. Three K L neutral decay modes, K L → 3 π 0, K L → 2 π 0, and K L → 2γ, were used to measure the K L flux in the beam line in the 2013 KOTO engineering run. A Monte Carlo simulationmore » was used to estimate the detector acceptance for these decays. Agreement was found between the simulation model and the experimental data, and the remaining systematic uncertainty was estimated at the 1.4% level. Here, the K L flux was measured as (4.183 ± 0.017 stat. ± 0.059 sys.) x 10 7 K L per 2 x 10 14 protons on a 66-mm-long Au target.« less

Hydrogen Fuel Cell on a Helicopter: A System Engineering Approach

NASA Astrophysics Data System (ADS)

Nesheiwat, Rod

Hydrogen fuel cells have been previously investigated as a viable replacement to traditional gas turbine auxiliary power unit onboard fixed wing commercial jets. However, so far no study has attempted to extend their applicability to rotary wing aircrafts. To aid in the advancement of such innovative technologies, a holistic technical approach is required to ensure risk reduction and cost effectiveness throughout the product lifecycle. This paper will evaluate the feasibility of replacing a gas turbine auxiliary power unit on a helicopter with a direct hydrogen, air breathing, proton exchange membrane fuel cell, all while emphasizing a system engineering approach that utilize a specialized set of tools and artifacts.

Electricity from the Silk Cocoon Membrane

PubMed Central

Tulachan, Brindan; Meena, Sunil Kumar; Rai, Ratan Kumar; Mallick, Chandrakant; Kusurkar, Tejas Sanjeev; Teotia, Arun Kumar; Sethy, Niroj Kumar; Bhargava, Kalpana; Bhattacharya, Shantanu; Kumar, Ashok; Sharma, Raj Kishore; Sinha, Neeraj; Singh, Sushil Kumar; Das, Mainak

2014-01-01

Silk cocoon membrane (SCM) is an insect engineered structure. We studied the electrical properties of mulberry (Bombyx mori) and non-mulberry (Tussar, Antheraea mylitta) SCM. When dry, SCM behaves like an insulator. On absorbing moisture, it generates electrical current, which is modulated by temperature. The current flowing across the SCM is possibly ionic and protonic in nature. We exploited the electrical properties of SCM to develop simple energy harvesting devices, which could operate low power electronic systems. Based on our findings, we propose that the temperature and humidity dependent electrical properties of the SCM could find applications in battery technology, bio-sensor, humidity sensor, steam engines and waste heat management. PMID:24961354

Electricity from the silk cocoon membrane.

PubMed

Tulachan, Brindan; Meena, Sunil Kumar; Rai, Ratan Kumar; Mallick, Chandrakant; Kusurkar, Tejas Sanjeev; Teotia, Arun Kumar; Sethy, Niroj Kumar; Bhargava, Kalpana; Bhattacharya, Shantanu; Kumar, Ashok; Sharma, Raj Kishore; Sinha, Neeraj; Singh, Sushil Kumar; Das, Mainak

2014-06-25

Silk cocoon membrane (SCM) is an insect engineered structure. We studied the electrical properties of mulberry (Bombyx mori) and non-mulberry (Tussar, Antheraea mylitta) SCM. When dry, SCM behaves like an insulator. On absorbing moisture, it generates electrical current, which is modulated by temperature. The current flowing across the SCM is possibly ionic and protonic in nature. We exploited the electrical properties of SCM to develop simple energy harvesting devices, which could operate low power electronic systems. Based on our findings, we propose that the temperature and humidity dependent electrical properties of the SCM could find applications in battery technology, bio-sensor, humidity sensor, steam engines and waste heat management.

Synthesis of electroactive tetraaniline grafted polyethylenimine for tissue engineering

NASA Astrophysics Data System (ADS)

Dong, Shilei; Han, Lu; Cai, Muhang; Li, Luhai; Wei, Yan

2015-07-01

Tetraaniline grafted polyethylenimine (AT-PEI) was successfully synthesized in this study. Proton Nuclear Magnetic Resonance (1H NMR) Spectroscopy was used to determine the structure of carboxyl-capped aniline tetramer (AT-COOH) and AT-PEI. UV-Vis spectroscopy and Fourier transform infrared (FT-IR) spectroscopy were employed to characterize the absorption spectrum of the obtained AT-PEI samples. The morphology of AT-PEI copolymers in aqueous solution was determined by Scanning electron microscope (SEM). Moreover, AT-PEI copolymers demonstrated excellent solubility in aqueous solution and possessed electroactivity by cyclic voltammogram (CV) curves, which showed its potential application in the field of tissue engineering.

Electricity from the Silk Cocoon Membrane

NASA Astrophysics Data System (ADS)

Tulachan, Brindan; Meena, Sunil Kumar; Rai, Ratan Kumar; Mallick, Chandrakant; Kusurkar, Tejas Sanjeev; Teotia, Arun Kumar; Sethy, Niroj Kumar; Bhargava, Kalpana; Bhattacharya, Shantanu; Kumar, Ashok; Sharma, Raj Kishore; Sinha, Neeraj; Singh, Sushil Kumar; Das, Mainak

2014-06-01

Silk cocoon membrane (SCM) is an insect engineered structure. We studied the electrical properties of mulberry (Bombyx mori) and non-mulberry (Tussar, Antheraea mylitta) SCM. When dry, SCM behaves like an insulator. On absorbing moisture, it generates electrical current, which is modulated by temperature. The current flowing across the SCM is possibly ionic and protonic in nature. We exploited the electrical properties of SCM to develop simple energy harvesting devices, which could operate low power electronic systems. Based on our findings, we propose that the temperature and humidity dependent electrical properties of the SCM could find applications in battery technology, bio-sensor, humidity sensor, steam engines and waste heat management.

MESUR Pathfinder Science Investigations

NASA Technical Reports Server (NTRS)

Golombek, M.

1993-01-01

The MESUR (Mars Environmental Survey) Pathfinder mission is the first Discovery mission planned for launch in 1996. MESUR Pathfinder is designed as an engineering demonstration of the entry, descent and landing approach to be employed by the follow-on MESUR Network mission, which will land of order 10 small stations on the surface of Mars to investigate interior, atmospheric and surface properties. Pathfinder is a small Mars lander, equipped with a microrover to deploy instruments and explore the local landing site. Instruments selected for Pathfinder include a surface imager on a 1 m pop-up mast (stereo with spectral filters), an atmospheric structure instrument/surface meteorology package, and an alpha proton x-ray spectrometer. The microrover will carry the alpha proton x-ray spectrometer to a number of different rocks and surface materials and provide close-up imaging...

Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates

PubMed Central

Lewin, Ross; Goodall, Mark; Thompson, Mark L; Leigh, James; Breuer, Michael; Baldenius, Kai; Micklefield, Jason

2015-01-01

The enzyme aryl/alkenyl malonate decarboxylase (AMDase) catalyses the enantioselective decarboxylative protonation (EDP) of a range of disubstituted malonic acids to give homochiral carboxylic acids that are valuable synthetic intermediates. AMDase exhibits a number of advantages over the non-enzymatic EDP methods developed to date including higher enantioselectivity and more environmentally benign reaction conditions. In this report, AMDase and engineered variants have been used to produce a range of enantioenriched heteroaromatic α-hydroxycarboxylic acids, including pharmaceutical precursors, from readily accessible α-hydroxymalonates. The enzymatic method described here represents an improvement upon existing synthetic chemistry methods that have been used to produce similar compounds. The relationship between the structural features of these new substrates and the kinetics associated with their enzymatic decarboxylation is explored, which offers further insight into the mechanism of AMDase. PMID:25766433

Nanotechnology and regenerative therapeutics in plastic surgery: The next frontier

PubMed Central

Tan, Aaron; Chawla, Reema; Natasha, G; Mahdibeiraghdar, Sara; Jeyaraj, Rebecca; Rajadas, Jayakumar; Hamblin, Michael R.; Seifalian, Alexander M.

2015-01-01

Summary The rapid ascent of nanotechnology and regenerative therapeutics as applied to medicine and surgery has seen an exponential rise in the scale of research generated in this field. This is evidenced not only by the sheer volume of papers dedicated to nanotechnology but also in a large number of new journals dedicated to nanotechnology and regenerative therapeutics specifically to medicine and surgery. Aspects of nanotechnology that have already brought benefits to these areas include advanced drug delivery platforms, molecular imaging and materials engineering for surgical implants. Particular areas of interest include nerve regeneration, burns and wound care, artificial skin with nanoelectronic sensors and head and neck surgery. This study presents a review of nanotechnology and regenerative therapeutics, with focus on its applications and implications in plastic surgery. PMID:26422652

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.

PubMed

Hauert, Sabine; Bhatia, Sangeeta N

2014-09-01

Nanoparticles are designed to deliver therapeutics and diagnostics selectively to tumors. Their size, shape, charge, material, coating, and cargo determine their individual functionalities. A systems approach could help predict the behavior of trillions of nanoparticles interacting in complex tumor environments. Engineering these nanosystems may lead to biomimetic strategies where interactions between nanoparticles and their environment give rise to cooperative behaviors typically seen in natural self-organized systems. Examples include nanoparticles that communicate the location of a tumor to amplify tumor homing or self-assemble and disassemble to optimize nanoparticle transport. The challenge is to discover which nanoparticle designs lead to a desired system behavior. To this end, novel nanomaterials, deep understanding of biology, and computational tools are emerging as the next frontier. Copyright © 2014 Elsevier Ltd. All rights reserved.

Multibody Simulation Software Testbed for Small-Body Exploration and Sampling

NASA Technical Reports Server (NTRS)

Acikmese, Behcet; Blackmore, James C.; Mandic, Milan

2011-01-01

G-TAG is a software tool for the multibody simulation of a spacecraft with a robotic arm and a sampling mechanism, which performs a touch-and-go (TAG) maneuver for sampling from the surface of a small celestial body. G-TAG utilizes G-DYN, a multi-body simulation engine described in the previous article, and interfaces to controllers, estimators, and environmental forces that affect the spacecraft. G-TAG can easily be adapted for the analysis of the mission stress cases to support the design of a TAG system, as well as for comprehensive Monte Carlo simulations to analyze and evaluate a particular TAG system design. Any future small-body mission will benefit from using G-TAG, which has already been extensively used in Comet Odyssey and Galahad Asteroid New Frontiers proposals.

Space Station Freedom Gateway to the Future

NASA Technical Reports Server (NTRS)

1992-01-01

The first inhabited outpost on the frontier of space will be a place to live, work, and discover. Experiments conducted on Freedom will advance scientific knowledge about our world, our environment, and ourselves. We will learn how to adapt to the space environment and to build and operate new spacecraft with destinations far beyond Earth, continuing the tradition of exploration that began with a journey to the Moon. What we learn from living and working on Freedom will strengthen our expertise in science and engineering, promote national research and development initiatives and inspire another generation of Americans to push forward and onward. On the eve of the 21st century, Space Station Freedom will be our gateway to the future. This material covers gateways to space, research, discovery, utilization, benefits, and NASA.

Research and development at ORNL/CESAR towards cooperating robotic systems for hazardous environments

NASA Technical Reports Server (NTRS)

Mann, R. C.; Fujimura, K.; Unseren, M. A.

1992-01-01

One of the frontiers in intelligent machine research is the understanding of how constructive cooperation among multiple autonomous agents can be effected. The effort at the Center for Engineering Systems Advanced Research (CESAR) at the Oak Ridge National Laboratory (ORNL) focuses on two problem areas: (1) cooperation by multiple mobile robots in dynamic, incompletely known environments; and (2) cooperating robotic manipulators. Particular emphasis is placed on experimental evaluation of research and developments using the CESAR robot system testbeds, including three mobile robots, and a seven-axis, kinematically redundant mobile manipulator. This paper summarizes initial results of research addressing the decoupling of position and force control for two manipulators holding a common object, and the path planning for multiple robots in a common workspace.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pope, Jason E.

For more than 50 years, the United States (U.S.) Department of Energy’s (DOE’s) Pacific Northwest National Laboratory (PNNL) has advanced the frontiers of science and technology through courageous discovery and innovation. Our multidisciplinary team of more than 4,400 scientists, engineers, and support professionals is tackling global sustainability challenges in our science, energy, environmental, and security missions. For example, our research on how human and natural systems interact is critical to informing sustainable solutions to the nation’s energy and environmental challenges. PNNL is equally committed to sustainability right here at home, and we are making excellent progress toward the goals describedmore » in this plan. We are working on ongoing challenges, such as reducing the energy required to meet our research mission and promoting conservation among our employees.« less

Impact of Informal Science Education on Children's Attitudes About Science

NASA Astrophysics Data System (ADS)

Wulf, Rosemary; Mayhew, Laurel M.; Finkelstein, Noah D.

2010-10-01

The JILA Physics Frontier Center Partnerships for Informal Science Education in the Community (PISEC) provides informal afterschool inquiry-based science teaching opportunities for university participants with children typically underrepresented in science. We focus on the potential for this program to help increase children's interest in science, mathematics, and engineering and their understanding of the nature of science by validating the Children's Attitude Survey, which is based on the Colorado Learning Attitudes about Science Survey [1] and designed to measure shifts in children's attitudes about science and the nature of science. We present pre- and post-semester results for several semesters of the PISEC program, and demonstrate that, unlike most introductory physics courses in college, our after-school informal science programs support and promote positive attitudes about science.

The Walk Forward of Sun-Grown Green-Thing Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huetteman, Carl; Burroff-Murr, Pam; Anderson, Sarah

Representing the Center for Direct Catalytic Conversion of Biomass to Biofuels (C3Bio), this document is one of the entries in the Ten Hundred and One Word Challenge and was awarded "Best Tagline." As part of the challenge, the 46 Energy Frontier Research Centers were invited to represent their science in images, cartoons, photos, words and original paintings, but any descriptions or words could only use the 1000 most commonly used words in the English language, with the addition of one word important to each of the EFRCs and the mission of DOE: energy. The mission of C3Bio at Purdue Universitymore » is to integrate fundamental knowledge and enable technologies for catalytic conversion of engineered biomass to advanced biofuels and value-added products.« less

Interface control of bulk ferroelectric polarization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, P; Luo, Weidong; Yi, D.

2012-01-01

The control of material interfaces at the atomic level has led to no- vel interfacial properties and functionalities. In particular, the study of polar discontinuities at interfaces between complex oxides lies at the frontier of modern condensed matter research. Here we em- ploy a combination of experimental measurements and theoretical calculations to demonstrate the control of a bulk property, namely ferroelectric polarization, of a heteroepitaxial bilayer by precise atomic-scale interface engineering. More specifically, the control is achieved by exploiting the interfacial valence mismatch to influence the electrostatic potential step across the interface, which manifests itself as the biased-voltage in ferroelectricmore » hysteresis loops and determines the ferroelectric state. A broad study of diverse systems comprising different ferroelectrics and conducting perovskite un- derlayers extends the generality of this phenomenon.« less

Learning the Task Management Space of an Aircraft Approach Model

NASA Technical Reports Server (NTRS)

Krall, Joseph; Menzies, Tim; Davies, Misty

2014-01-01

Validating models of airspace operations is a particular challenge. These models are often aimed at finding and exploring safety violations, and aim to be accurate representations of real-world behavior. However, the rules governing the behavior are quite complex: nonlinear physics, operational modes, human behavior, and stochastic environmental concerns all determine the responses of the system. In this paper, we present a study on aircraft runway approaches as modeled in Georgia Tech's Work Models that Compute (WMC) simulation. We use a new learner, Genetic-Active Learning for Search-Based Software Engineering (GALE) to discover the Pareto frontiers defined by cognitive structures. These cognitive structures organize the prioritization and assignment of tasks of each pilot during approaches. We discuss the benefits of our approach, and also discuss future work necessary to enable uncertainty quantification.

Community Services New Frontier: Establishing the Ties That Bind.

ERIC Educational Resources Information Center

Vaughan, George B.

1991-01-01

Examines the historical roots of community services in community colleges. Offers suggestions for keeping community colleges on the frontier of the development of these institutions (e.g., bringing the program into the instructional mainstream, emphasizing program planning, encouraging instructional innovation.) (DMM)

Community Services New Frontier: Establishing the Ties That Bind.

ERIC Educational Resources Information Center

Vaughan, George B.

1984-01-01

Looks at the historical roots of community services in community colleges. Offers suggestions for keeping community colleges on the frontier of the development of these institutions (e.g., bringing the program into the instructional mainstream, emphasizing program planning, encouraging instructional innovation. (DMM)

Cyberspace: The Community Frontier.

ERIC Educational Resources Information Center

Albanese, Andrew Richard

2002-01-01

This interview with John Perry Barlow (Grated Dead lyricist / technology expert) addresses issues concerning cyberspace, technology, and culture. Topics include the idea of community; the Internet; the Electronic Frontier Foundation; the role of libraries; print materials; concepts of information; peer-to-peer technology; file sharing; and…

Strategic assessment of the Highway Performance Monitoring System

DOT National Transportation Integrated Search

1995-02-01

The appendix contains a series of border crossing profiles covering the major, and in some cases, minor crossings in the border frontier. The frontier itself is a definition created for the 6015 Study to aid in the analysis of trade and traffic flows...

Resources for Teaching about the Frontier.

ERIC Educational Resources Information Center

Seiter, David

1988-01-01

Highlights materials relating to the U.S. frontier during the 19th century by citing journal articles and documents related to this topic. Indicates the means for obtaining these works which deal with rural schooling, historical demography, Native Americans, music, revivalism, and Black cowboys. (KO)

Experimental Research at the Intensity Frontier in High Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshak, Marvin L.

2014-06-30

This Final Report describes DOE-supported Intensity Frontier research by the University of Minnesota during the interval April 1, 2011 to March 31, 2014. Primary activities included the MINOS, NOvA and LBNE Experiments and Heavy Quark studies at BES III.

Simulation Needs and Priorities of the Fermilab Intensity Frontier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvira, V. D.; Genser, K. L.; Hatcher, R.

2015-06-11

Over a two-year period, the Physics and Detector Simulations (PDS) group of the Fermilab Scientific Computing Division (SCD), collected information from Fermilab Intensity Frontier experiments on their simulation needs and concerns. The process and results of these activities are documented here.

Enhanced Proton Translocating Pyrophosphatase Activity Improves Nitrogen Use Efficiency in Romaine Lettuce1[C][W][OA

PubMed Central

Paez-Valencia, Julio; Sanchez-Lares, Jonathan; Marsh, Ellen; Dorneles, Liane T.; Santos, Mirella P.; Sanchez, Diego; Winter, Alexander; Murphy, Sean; Cox, Jennifer; Trzaska, Marcin; Metler, Jason; Kozic, Alex; Facanha, Arnoldo R.; Schachtman, Daniel; Sanchez, Charles A.; Gaxiola, Roberto A.

2013-01-01

Plant nitrate (NO3−) acquisition depends on the combined activities of root high- and low-affinity NO3− transporters and the proton gradient generated by the plasma membrane H+-ATPase. These processes are coordinated with photosynthesis and the carbon status of the plant. Here, we present the characterization of romaine lettuce (Lactuca sativa ‘Conquistador’) plants engineered to overexpress an intragenic gain-of-function allele of the type I proton translocating pyrophosphatase (H+-PPase) of Arabidopsis (Arabidopsis thaliana). The proton-pumping and inorganic pyrophosphate hydrolytic activities of these plants are augmented compared with control plants. Immunohistochemical data show a conspicuous increase in H+-PPase protein abundance at the vasculature of the transgenic plants. Transgenic plants displayed an enhanced rhizosphere acidification capacity consistent with the augmented plasma membrane H+-ATPase proton transport values, and ATP hydrolytic capacities evaluated in vitro. These transgenic lines outperform control plants when challenged with NO3− limitations in laboratory, greenhouse, and field scenarios. Furthermore, we report the characterization of a lettuce LsNRT2.1 gene that is constitutive up-regulated in the transgenic plants. Of note, the expression of the LsNRT2.1 gene in control plants is regulated by NO3− and sugars. Enhanced accumulation of 15N-labeled fertilizer by transgenic lettuce compared with control plants was observed in greenhouse experiments. A negative correlation between the level of root soluble sugars and biomass is consistent with the strong root growth that characterizes these transgenic plants. PMID:23307651

The Frontier Fields: Survey Design and Initial Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lotz, J. M.; Koekemoer, A.; Grogin, N.

What are the faintest distant galaxies we can see with the Hubble Space Telescope ( HST ) now, before the launch of the James Webb Space Telescope ? This is the challenge taken up by the Frontier Fields, a Director’s discretionary time campaign with HST and the Spitzer Space Telescope to see deeper into the universe than ever before. The Frontier Fields combines the power of HST and Spitzer with the natural gravitational telescopes of massive high-magnification clusters of galaxies to produce the deepest observations of clusters and their lensed galaxies ever obtained. Six clusters—Abell 2744, MACSJ0416.1-2403, MACSJ0717.5+3745, MACSJ1149.5+2223, Abellmore » S1063, and Abell 370—have been targeted by the HST ACS/WFC and WFC3/IR cameras with coordinated parallel fields for over 840 HST orbits. The parallel fields are the second-deepest observations thus far by HST with 5 σ point-source depths of ∼29th ABmag. Galaxies behind the clusters experience typical magnification factors of a few, with small regions magnified by factors of 10–100. Therefore, the Frontier Field cluster HST images achieve intrinsic depths of ∼30–33 mag over very small volumes. Spitzer has obtained over 1000 hr of Director’s discretionary imaging of the Frontier Field cluster and parallels in IRAC 3.6 and 4.5 μ m bands to 5 σ point-source depths of ∼26.5, 26.0 ABmag. We demonstrate the exceptional sensitivity of the HST Frontier Field images to faint high-redshift galaxies, and review the initial results related to the primary science goals.« less

Efficient Discovery of De-identification Policies Through a Risk-Utility Frontier

PubMed Central

Xia, Weiyi; Heatherly, Raymond; Ding, Xiaofeng; Li, Jiuyong; Malin, Bradley

2014-01-01

Modern information technologies enable organizations to capture large quantities of person-specific data while providing routine services. Many organizations hope, or are legally required, to share such data for secondary purposes (e.g., validation of research findings) in a de-identified manner. In previous work, it was shown de-identification policy alternatives could be modeled on a lattice, which could be searched for policies that met a prespecified risk threshold (e.g., likelihood of re-identification). However, the search was limited in several ways. First, its definition of utility was syntactic - based on the level of the lattice - and not semantic - based on the actual changes induced in the resulting data. Second, the threshold may not be known in advance. The goal of this work is to build the optimal set of policies that trade-off between privacy risk (R) and utility (U), which we refer to as a R-U frontier. To model this problem, we introduce a semantic definition of utility, based on information theory, that is compatible with the lattice representation of policies. To solve the problem, we initially build a set of policies that define a frontier. We then use a probability-guided heuristic to search the lattice for policies likely to update the frontier. To demonstrate the effectiveness of our approach, we perform an empirical analysis with the Adult dataset of the UCI Machine Learning Repository. We show that our approach can construct a frontier closer to optimal than competitive approaches by searching a smaller number of policies. In addition, we show that a frequently followed de-identification policy (i.e., the Safe Harbor standard of the HIPAA Privacy Rule) is suboptimal in comparison to the frontier discovered by our approach. PMID:25520961

Efficient Discovery of De-identification Policies Through a Risk-Utility Frontier.

PubMed

Xia, Weiyi; Heatherly, Raymond; Ding, Xiaofeng; Li, Jiuyong; Malin, Bradley

2013-01-01

Modern information technologies enable organizations to capture large quantities of person-specific data while providing routine services. Many organizations hope, or are legally required, to share such data for secondary purposes (e.g., validation of research findings) in a de-identified manner. In previous work, it was shown de-identification policy alternatives could be modeled on a lattice, which could be searched for policies that met a prespecified risk threshold (e.g., likelihood of re-identification). However, the search was limited in several ways. First, its definition of utility was syntactic - based on the level of the lattice - and not semantic - based on the actual changes induced in the resulting data. Second, the threshold may not be known in advance. The goal of this work is to build the optimal set of policies that trade-off between privacy risk (R) and utility (U), which we refer to as a R-U frontier. To model this problem, we introduce a semantic definition of utility, based on information theory, that is compatible with the lattice representation of policies. To solve the problem, we initially build a set of policies that define a frontier. We then use a probability-guided heuristic to search the lattice for policies likely to update the frontier. To demonstrate the effectiveness of our approach, we perform an empirical analysis with the Adult dataset of the UCI Machine Learning Repository. We show that our approach can construct a frontier closer to optimal than competitive approaches by searching a smaller number of policies. In addition, we show that a frequently followed de-identification policy (i.e., the Safe Harbor standard of the HIPAA Privacy Rule) is suboptimal in comparison to the frontier discovered by our approach.

Equation of Motion of an Interstellar Bussard Ramjet with Radiation and Mass Losses

ERIC Educational Resources Information Center

Semay, Claude; Silvestre-Brac, Bernard

2008-01-01

An interstellar Bussard ramjet is a spaceship using the protons of the interstellar medium in a fusion engine to produce thrust. In recent papers, it was shown that the relativistic equation of motion of an ideal ramjet and that of a ramjet with radiation loss are analytical. When a mass loss appears, the limit speed of the ramjet is more strongly…

Sport without Frontiers: Just an Unrealistic Wish?

ERIC Educational Resources Information Center

Koch, Mathias

1990-01-01

Describes and recommends the project, Sports without Frontiers, as a useful tool in the integration of foreign immigrants. Suggests that employment of foreigners in West Germany's job market means the needs of foreigners must be addressed. Argues this program promotes social integration through sports. (NL)

High Energy Physics

Science.gov Websites

Untitled Document [Argonne Logo] [DOE Logo] High Energy Physics Home Division ES&H Personnel Collider Physics Cosmic Frontier Cosmic Frontier Theory & Computing Detector R&D Electronic Design Mechanical Design Neutrino Physics Theoretical Physics Seminars HEP Division Seminar HEP Lunch Seminar HEP

Frontier Force: The Romance of the Foreign Legion.

ERIC Educational Resources Information Center

Heggoy, Alf Andrew

1985-01-01

Of all the frontier forces in the modern world, the French Foreign Legion is perhaps the most widely known and yet the least understood. The realities and mystique of the Legion from the time it was formed in 1831 to the present are discussed. (RM)

Hazardous Waste Cleanup: Frontier Chemical Waste Process Incorporated in Pendleton, New York

EPA Pesticide Factsheets

Frontier Chemical Waste Process, Inc. is located at 7025 Townline Road, Pendleton, New York. This site was used for the treatment of industrial wastes from 1959 to 1974, with many wastes being discharged to the lake on the property (Quarry Lake).

Accounting for Cosmic Variance in Studies of Gravitationally Lensed High-redshift Galaxies in the Hubble Frontier Field Clusters

NASA Astrophysics Data System (ADS)

Robertson, Brant E.; Ellis, Richard S.; Dunlop, James S.; McLure, Ross J.; Stark, Dan P.; McLeod, Derek

2014-12-01

Strong gravitational lensing provides a powerful means for studying faint galaxies in the distant universe. By magnifying the apparent brightness of background sources, massive clusters enable the detection of galaxies fainter than the usual sensitivity limit for blank fields. However, this gain in effective sensitivity comes at the cost of a reduced survey volume and, in this Letter, we demonstrate that there is an associated increase in the cosmic variance uncertainty. As an example, we show that the cosmic variance uncertainty of the high-redshift population viewed through the Hubble Space Telescope Frontier Field cluster Abell 2744 increases from ~35% at redshift z ~ 7 to >~ 65% at z ~ 10. Previous studies of high-redshift galaxies identified in the Frontier Fields have underestimated the cosmic variance uncertainty that will affect the ultimate constraints on both the faint-end slope of the high-redshift luminosity function and the cosmic star formation rate density, key goals of the Frontier Field program.

[Impact of the funding reform of teaching hospitals in Brazil].

PubMed

Lobo, M S C; Silva, A C M; Lins, M P E; Fiszman, R

2009-06-01

To assess the impact of funding reform on the productivity of teaching hospitals. Based on the Information System of Federal University Hospitals of Brazil, 2003 and 2006 efficiency and productivity were measured using frontier methods with a linear programming technique, data envelopment analysis, and input-oriented variable returns to scale model. The Malmquist index was calculated to detect changes during the study period: 'technical efficiency change,' or the relative variation of the efficiency of each unit; and 'technological change' after frontier shift. There was 51% mean budget increase and improvement of technical efficiency of teaching hospitals (previously 11, 17 hospitals reached the empirical efficiency frontier) but the same was not seen for the technology frontier. Data envelopment analysis set benchmark scores for each inefficient unit (before and after reform) and there was a positive correlation between technical efficiency and teaching intensity and dedication. The reform promoted management improvements but there is a need of further follow-up to assess the effectiveness of funding changes.

Engineering ESPT pathways based on structural analysis of LSSmKate red fluorescent proteins with large Stokes shift.

PubMed

Piatkevich, Kiryl D; Malashkevich, Vladimir N; Almo, Steven C; Verkhusha, Vladislav V

2010-08-11

LSSmKate1 and LSSmKate2 are monomeric red fluorescent proteins (RFPs) with large Stokes shifts (LSSs), which allows for efficient separation of absorbance and emission maxima, as well as for excitation with conventional two-photon laser sources. These LSSmKates differ by a single amino acid substitution at position 160 and exhibit absorbance maxima around 460 nm, corresponding to a neutral DsRed-like chromophore. However, excitation at 460 nm leads to fluorescence emission above 600 nm. Structures of LSSmKate1 and LSSmKate2, determined at resolutions of 2.0 and 1.5 A, respectively, revealed that the predominant DsRed-chromophore configurations are cis for LSSmKate1 but trans for LSSmKate2. Crystallographic and mutagenesis analyses, as well as isotope and temperature dependences, suggest that an excited-state proton transfer (ESPT) is responsible for the LSSs observed in LSSmKates. Hydrogen bonding between the chromophore hydroxyl and Glu160 in LSSmKate1 and a proton relay involving the chromophore tyrosine hydroxyl, Ser158, and the Asp160 carboxylate in LSSmKate2 represent the putative ESPT pathways. Comparisons with mKeima LSS RFP suggest that similar proton relays could be engineered in other FPs. Accordingly, we mutated positions 158 and 160 in several conventional red-shifted FPs, including mNeptune, mCherry, mStrawberry, mOrange, and mKO, and the resulting FP variants exhibited LSS fluorescence emission in a wide range of wavelengths from 560 to 640 nm. These data suggest that different chromophores formed by distinct tripeptides in different environments can be rationally modified to yield RFPs with novel photochemical properties.

First Results from Colorado Student Space Weather Experiment (CSSWE): Differential Flux Measurements of Energetic Particles in a Highly Inclined Low Earth Orbit

NASA Astrophysics Data System (ADS)

Li, X.; Palo, S. E.; Kohnert, R.; Gerhardt, D.; Blum, L. W.; Schiller, Q.; Turner, D. L.; Tu, W.

2012-12-01

The Colorado Student Space Weather Experiment (CSSWE) is a 3-unit (10cm x 10cm x 30cm) CubeSat mission funded by the National Science Foundation, scheduled for launch into a low-Earth, polar orbit after August 14th, 2012 as a secondary payload under NASA's Educational Launch of Nanosatellites (ELaNa) program. The science objectives of CSSWE are to investigate the relationship of the location, magnitude, and frequency of solar flares to the timing, duration, and energy spectrum of solar energetic particles (SEP) reaching Earth, and to determine the precipitation loss and the evolution of the energy spectrum of radiation belt electrons. CSSWE contains a single science payload, the Relativistic Electron and Proton Telescope integrated little experiment (REPTile), which is a miniaturization of the Relativistic Electron and Proton Telescope (REPT) built at the Laboratory for Atmospheric and Space Physics (LASP). The REPT instrument will fly onboard the NASA/Radiation Belt Storm Probes (RBSP) mission, which consists of two identical spacecraft scheduled to launch after August 23rd, 2012 that will go through the heart of the radiation belts in a low inclination orbit. CSSWE's REPTile is designed to measure the directional differential flux of protons ranging from 10 to 40 MeV and electrons from 0.5 to >3 MeV. Such differential flux measurements have significant science value, and a number of engineering challenges were overcome to enable these clean measurements to be made under the mass and power limits of a CubeSat. The CSSWE is an ideal class project, providing training for the next generation of engineers and scientists over the full life-cycle of a satellite project. We will report the first results from this exciting mission.

Science Results from Colorado Student Space Weather Experiment (CSSWE): Energetic Particle Distribution in Near Earth Environment

NASA Astrophysics Data System (ADS)

Li, Xinlin

2013-04-01

The Colorado Student Space Weather Experiment (CSSWE) is a 3-unit (10cm x 10cm x 30cm) CubeSat mission funded by the National Science Foundation, launched into a low-Earth, polar orbit on 13 September 2012 as a secondary payload under NASA's Educational Launch of Nanosatellites (ELaNa) program. The science objectives of CSSWE are to investigate the relationship of the location, magnitude, and frequency of solar flares to the timing, duration, and energy spectrum of solar energetic particles reaching Earth, and to determine the precipitation loss and the evolution of the energy spectrum of trapped radiation belt electrons. CSSWE contains a single science payload, the Relativistic Electron and Proton Telescope integrated little experiment (REPTile), which is a miniaturization of the Relativistic Electron and Proton Telescope (REPT) built at the Laboratory for Atmospheric and Space Physics for NASA/Van Allen Probes mission, which consists of two identical spacecraft, launched 30 August 2012, that traverse the heart of the radiation belts in a low inclination orbit. CSSWE's REPTile is designed to measure the directional differential flux of protons ranging from 10 to 40 MeV and electrons from 0.5 to >3.3 MeV. The commissioning phase was completed and REPTile was activated on 4 October 2012. The data are very clean, far exceeding expectations! A number of engineering challenges had to be overcome to achieve such clean measurements under the mass and power limits of a CubeSat. The CSSWE is also an ideal class project, providing training for the next generation of engineers and scientists over the full life-cycle of a satellite project.

Nanoscale NMR spectroscopy and imaging of multiple nuclear species.

PubMed

DeVience, Stephen J; Pham, Linh M; Lovchinsky, Igor; Sushkov, Alexander O; Bar-Gill, Nir; Belthangady, Chinmay; Casola, Francesco; Corbett, Madeleine; Zhang, Huiliang; Lukin, Mikhail; Park, Hongkun; Yacoby, Amir; Walsworth, Ronald L

2015-02-01

Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) provide non-invasive information about multiple nuclear species in bulk matter, with wide-ranging applications from basic physics and chemistry to biomedical imaging. However, the spatial resolution of conventional NMR and MRI is limited to several micrometres even at large magnetic fields (>1 T), which is inadequate for many frontier scientific applications such as single-molecule NMR spectroscopy and in vivo MRI of individual biological cells. A promising approach for nanoscale NMR and MRI exploits optical measurements of nitrogen-vacancy (NV) colour centres in diamond, which provide a combination of magnetic field sensitivity and nanoscale spatial resolution unmatched by any existing technology, while operating under ambient conditions in a robust, solid-state system. Recently, single, shallow NV centres were used to demonstrate NMR of nanoscale ensembles of proton spins, consisting of a statistical polarization equivalent to ∼100-1,000 spins in uniform samples covering the surface of a bulk diamond chip. Here, we realize nanoscale NMR spectroscopy and MRI of multiple nuclear species ((1)H, (19)F, (31)P) in non-uniform (spatially structured) samples under ambient conditions and at moderate magnetic fields (∼20 mT) using two complementary sensor modalities.

Proton exchange membrane fuel cells for space and electric vehicle applications: From basic research to technology development

NASA Technical Reports Server (NTRS)

Srinivasan, Supramaniam; Mukerjee, Sanjeev; Parthasarathy, A.; CesarFerreira, A.; Wakizoe, Masanobu; Rho, Yong Woo; Kim, Junbom; Mosdale, Renaut A.; Paetzold, Ronald F.; Lee, James

1994-01-01

The proton exchange membrane fuel cell (PEMFC) is one of the most promising electrochemical power sources for space and electric vehicle applications. The wide spectrum of R&D activities on PEMFC's, carried out in our Center from 1988 to date, is as follows (1) Electrode Kinetic and Electrocatalysis of Oxygen Reduction; (2) Optimization of Structures of Electrodes and of Membrane and Electrode Assemblies; (3) Selection and Evaluation of Advanced Proton Conducting Membranes and of Operating Conditions to Attain High Energy Efficiency; (4) Modeling Analysis of Fuel Cell Performance and of Thermal and Water Management; and (5) Engineering Design and Development of Multicell Stacks. The accomplishments on these tasks may be summarized as follows: (1) A microelectrode technique was developed to determine the electrode kinetic parameters for the fuel cell reactions and mass transport parameters for the H2 and O2 reactants in the proton conducting membrane. (2) High energy efficiencies and high power densities were demonstrated in PEMFCs with low platinum loading electrodes (0.4 mg/cm(exp 2) or less), advanced membranes and optimized structures of membrane and electrode assemblies, as well as operating conditions. (3) The modeling analyses revealed methods to minimize mass transport limitations, particularly with air as the cathodic reactant; and for efficient thermal and water management. (4) Work is in progress to develop multi-kilowatt stacks with the electrodes containing low platinum loadings.

The central engine of quasars and AGNs: A relativistic proton radiative shock

NASA Astrophysics Data System (ADS)

Kazanas, D.; Ellison, D. C.

1985-08-01

Active galactic nuclei (AGNs) and quasars (QSOs) appear to emit roughly equal energy per decade from radio to gamma-ray energies (e.g. Ramaty and Ligenfelter 1982). This argues strongly for a nonthermal radiation mechanism (see Rees 1984). In addition, statistical studies have indicated that the spectra of these objects in the IR-UV and 2 to 50 keV X-ray band, can be fitted very well with power laws of specific indices. These spectral indices do not seem to depend on the luminosity or morphology of the objects (Rothschild et al. 1983; Malkan 1984), and any theory should account for them in a basic and model independent way. If shocks accelerate relativistic protons via the first-order Fermi mechanism (e.g. Axfor 1981), the radiating electrons can be produced as secondaries throughout the source by proton-proton (p-p) collisions and pion decay, thus eliminating Compton losses (Protheroe and Kazanas 1983). As shown by Kazanas (1984), if relativistic electrons are injected at high energies, e+-e- pair production results in a steady state electron distribution that is very similar to that observed in AGNs, independent of the details of injection and the dynamics of the source. The conditions required by this mechanism are met in the shock model of Eichler (1984) and Ellison and Eichler (1984) which allows the self-consistent calculation of the shock acceleration efficiency.

Interfingering of the Frontier Formation and Aspen Shale, Cumberland Gap, Wyoming.

USGS Publications Warehouse

M'gonigle, J.

1982-01-01

The basal part, or the Chalk Creek Member, of the non-marine lower Frontier Formation (Upper Cretaceous) includes a thin coal bed that grades S into a carbonaceous shale. The latter plus associated sandstones and shales pinch out S of Cumberland Gap and lie stratigraphically below the top of the Aspen Shale. The beds in the upper part of the Aspen, in turn, pinch out within the Frontier Formation. The coal bed and equivalent carbonaceous shale represent in-place accumulation of peat. The interfingering suggests that in SW Wyoming the Lower/Upper Cretaceous boundary is within the Chalk Creek Member. -from Author

Rural migration: The driving force behind tropical deforestation on the settlement frontier

PubMed Central

Carr, David

2009-01-01

This paper reviews the state of knowledge and develops a conceptual model for researching frontier migration in the developing world with a focus on Latin America. Since only a small fraction of migrants move to forest frontiers, identifying people and place characteristics associated with this phenomenon could usefully inform policies aimed at forest conservation and rural development. Yet population scholars train their efforts on urban and international migration while land use/cover change researchers pay scant attention to these migration flows which directly antecede the most salient footprint of human occupation on the earth's surface: the conversion of forest to agricultural land. PMID:20485541

Exercising Trust to Power Technology.

ERIC Educational Resources Information Center

Winkler, Carol Ann K.

1998-01-01

Recounts the Nerinx Hall High School New Frontiers team's apprehension in the 1992 New Frontiers for Catholic Schools workshop, convened to write technology plans for Catholic schools. Describes faculty and student success in incorporating new multimedia technology into the curriculum, after the team developed a plan for the school. (VWC)

Construction of Consumption Possibility Frontiers in Principles Textbooks.

ERIC Educational Resources Information Center

Olson, Terry L.

1997-01-01

Explores the consequences of textbook authors' failure to recognize that producers can acquire the good in which they lack a comparative advantage through either trade or internal production. Examines variations in the construction and graphical depiction of consumption possibility frontiers in principles of economics textbooks. (MJP)

Mythic Evolution of "The New Frontier" in Mass Mediated Rhetoric.

ERIC Educational Resources Information Center

Rushing, Janice Hocker

1986-01-01

Combines "rhetorical narration" with K. Burke's dramatistic pentad to argue that definitional cultural myths are rhetorically meaningful in relation to social consciousness if both evolved teleologically. Delineates two phases in America's frontier myth associated with recent space fiction films' representation of a pentadic term's…

Report in the Energy and Intensity Frontiers, and Theoretical at Northwestern University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Velasco, Mayda; Schmitt, Michael; deGouvea, Andre

The Northwestern (NU) Particle Physics (PP) group involved in this report is active on all the following priority areas: Energy and Intensity Frontiers. The group is lead by 2 full profs. in experimental physics (Schmitt and Velasco), 3 full profs. in theoretical physics (de Gouvea, Low and Petriello), and Heidi Schellman who is now at Oregon State. Low and Petriello hold joint appointments with the HEP Division at Argonne National Laboratory. The theoretical PP research focuses on different aspects of PP phenomenology. de Gouvea dedicates a large fraction of his research efforts to understanding the origin of neutrino masses, neutrinomore » properties and uncovering other new phenomena, and investigating connections between neutrino physics and other aspects of PP. Low works on Higgs physics as well as new theories beyond the Standard Model. Petriello pursues a research program in precision QCD and its associated collider phenomenology. The main goal of this effort is to improve the Standard Model predictions for important LHC observables in order to enable discoveries of new physics. In recent years, the emphasis on experimental PP at NU has been in collider physics. NU expands its efforts in new directions in both the Intensity and the Cosmic Frontiers (not discussed in this report). In the Intensity Frontier, Schmitt has started a new effort on Mu2e. He was accepted as a collaborator in April 2015 and is identified with important projects. In the Energy Frontier, Hahn, Schmitt and Velasco continue to have a significant impact and expanded their CMS program to include R&D for the real-time L1 tracking trigger and the high granularity calorimeter needed for the high-luminosity LHC. Hahn is supported by an independent DOE Career Award and his work will not be discussed in this document. The NU analysis effort includes searches for rare and forbidden decays of the Higgs bosons, Z boson, top quark, dark matter and other physics beyond the standard model topics. Four students completed their PhD: Kubik is now contributing to the Cosmic Frontier program, Pollack to both the Intensity and Energy Frontiers and Pozdnyakov and Odell will continue in the Energy Frontier. All our research scientists, Anastassov, Oferzynski, Lusito, and Stoynev, have found new positions. The new post-docs are Trovato from Scuola Normale de Pisa, Odell from Northwestern and Bhattacharya from Brown. Trovato is now supported by Hahn, and so is Sung, previously at MIT.« less

The inevitable journey to being.

PubMed

Russell, Michael J; Nitschke, Wolfgang; Branscomb, Elbert

2013-07-19

Life is evolutionarily the most complex of the emergent symmetry-breaking, macroscopically organized dynamic structures in the Universe. Members of this cascading series of disequilibria-converting systems, or engines in Cottrell's terminology, become ever more complicated-more chemical and less physical-as each engine extracts, exploits and generates ever lower grades of energy and resources in the service of entropy generation. Each one of these engines emerges spontaneously from order created by a particular mother engine or engines, as the disequilibrated potential daughter is driven beyond a critical point. Exothermic serpentinization of ocean crust is life's mother engine. It drives alkaline hydrothermal convection and thereby the spontaneous production of precipitated submarine hydrothermal mounds. Here, the two chemical disequilibria directly causative in the emergence of life spontaneously arose across the mineral precipitate membranes separating the acidulous, nitrate-bearing CO2-rich, Hadean sea from the alkaline and CH4/H2-rich serpentinization-generated effluents. Essential redox gradients-involving hydrothermal CH4 and H2 as electron donors, CO2 and nitrate, nitrite, and ferric iron from the ambient ocean as acceptors-were imposed which functioned as the original 'carbon-fixing engine'. At the same time, a post-critical-point (milli)voltage pH potential (proton concentration gradient) drove the condensation of orthophosphate to produce a high energy currency: 'the pyrophosphatase engine'.

The Center for Material Science of Nuclear Fuel (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Allen, Todd (Director, Center for Material Science of Nuclear Fuel); CMSNF Staff

2017-12-09

'The Center for Material Science of Nuclear Fuel (CMSNF)' was submitted by the CMSNF to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CMSNF, an EFRC directed by Todd Allen at the Idaho National Laboratory is a partnership of scientists from six institutions: INL (lead), Colorado School of Mines, University of Florida, Florida State University, Oak Ridge National Laboratory, and the University of Wisconsin at Madison. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Materials Science of Nuclear Fuels is 'to achieve a first-principles based understanding of the effect of irradiation-induced defects and microstructures on thermal transport in oxide nuclear fuels.' Research topics are: phonons, thermal conductivity, nuclear, extreme environment, radiation effects, defects, and matter by design.

Saving the Sun for a Rainy Day (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Bullock, R. Morris (Director, Center for Molecular Electrocatalysis); CME Staff

2017-12-09

'Saving the Sun for a Rainy Day' was submitted by the Center for Molecular Electrocatalysis (CME) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CME, an EFRC directed by R. Morris Bullock at Pacific Northwest National Laboratory is a partnership of scientists from four institutions: PNNL (lead), Pensylvania State University, University of Washington, and the University of Wyoming. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Molecular Electrocatalysis is 'to understand, design and develop molecular electrocatalysts for solar fuel production and use.' Research topics are: catalysis (water), electrocatalysis, bio-inspired, electrical energy storage, fuel cells, hydrogen (fuel), matter by design, novel materials synthesis, and charge transport.

Liquid Sunshine to Fuel Your Car (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Breunig, Lloyd

"Liquid Sunshine to Fuel Your Car" was submitted by the Center for Lignocellulose Structure and Formation (CLSF) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CLSF is directed by Daniel Cosgrove at Pennsylvania State University and is a partnership of scientists from three institutions: Penn State (lead), North Carolina State University, and Virginia Tech University. The Office of Basic Energy Sciences in the U.S. Department of Energy's Officemore » of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Lignocellulose Structure and Formation is 'to dramatically increase our fundamental knowledge of the formation and physical interactions of bio-polymer networks in plant cell walls to provide a basis for improved methods for converting biomass into fuels.' Research topics are: biofuels (biomass), membrane, interfacial characterization, matter by design, and self-assembly.« less

Saving the Sun for a Rainy Day (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bullock, R. Morris

"Saving the Sun for a Rainy Day" was submitted by the Center for Molecular Electrocatalysis (CME) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CME, an EFRC directed by R. Morris Bullock at Pacific Northwest National Laboratory is a partnership of scientists from four institutions: PNNL (lead), Pennsylvania State University, University of Washington, and the University of Wyoming. The Office of Basic Energy Sciences in the U.S. Departmentmore » of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Molecular Electrocatalysis is 'to understand, design and develop molecular electrocatalysts for solar fuel production and use.' Research topics are: catalysis (water), electrocatalysis, bio-inspired, electrical energy storage, fuel cells, hydrogen (fuel), matter by design, novel materials synthesis, and charge transport.« less

Frontier Scientists' project probes audience science interests with website, social media, TV broadcast, game, and pop-up book

NASA Astrophysics Data System (ADS)

O'Connell, E. A.

2017-12-01

The Frontier Scientists National Science Foundation project titled Science in Alaska: Using Multimedia to Support Science Education produced research products in several formats: videos short and long, blogs, social media, a computer game, and a pop-up book. These formats reached distinctly different audiences. Internet users, public TV viewers, gamers, schools, and parents & young children were drawn to Frontier Scientists' research in direct and indirect ways. The analytics (our big data) derived from this media broadcast has given us insight into what works, what doesn't, next steps. We have evidence for what is needed to present science as an interesting, vital, and a necessary component for the general public's daily information diet and as an important tool for scientists to publicize research and to thrive in their careers. Collaborations with scientists at several Universities, USGS, Native organizations, tourism organizations, and Alaska Museums promoted accuracy of videos and increased viewing. For example, Erin Marbarger, at Anchorage Museum, edited, and provided Spark!Lab to test parents & child's interest in the pop-up book titled: The Adventures of Apun the Arctic Fox. Without a marketing budget Frontier Scientist's minimum publicity, during the three year project, still drew an audience. Frontier Scientists was awarded Best Website 2016 by the Alaska Press Club, and won a number of awards for short videos and TV programs.

Liquid Sunshine to Fuel Your Car (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Cosgrove, Daniel (Director, Center for Lignocellulose Structure and Formation); CLSF Staff

2017-12-09

'Liquid Sunshine to Fuel Your Car' was submitted by the Center for Lignocellulose Structure and Formation (CLSF) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CLSF is directed by Daniel Cosgrove at Pennsylvania State University and is a partnership of scientists from three institutions: Penn State (lead), North Caroline State University, and Virginia Tech University. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of the Center for Lignocellulose Structure and Formation is 'to dramatically increase our fundamental knowledge of the formation and physical interactions of bio-polymer networks in plant cell walls to provide a basis for improved methods for converting biomass into fuels.' Research topics are: biofuels (biomass), membrane, interfacial characterization, matter by design, and self-assembly.

ESAS-Derived Earth Departure Stage Design for Human Mars Exploration

NASA Technical Reports Server (NTRS)

Flaherty, Kevin; Grant, Michael; Korzun, Ashley; Malo-Molina, Faure; Steinfeldt, Bradley; Stahl, Benjamin; Wilhite, Alan

2007-01-01

The Vision for Space Exploration has set the nation on a course to have humans on Mars as early as 2030. To reduce the cost and risk associated with human Mars exploration, NASA is planning for the Mars architecture to leverage the lunar architecture as fully as possible. This study takes the defined launch vehicles and system capabilities from ESAS and extends their application to DRM 3.0 to design an Earth Departure Stage suitable for the cargo and crew missions to Mars. The impact of a propellant depot in LEO was assessed and sLzed for use with the EDS. To quantitatively assess and compare the effectiveness of alternative designs, an initial baseline architecture was defined using the ESAS launch vehicles and DRM 3.0. The baseline architecture uses three NTR engines, LH2 propellant, no propellant depot in LEO, and launches on the Ares I and Ares V. The Mars transfer and surface elements from DRM 3.0 were considered to be fixed payloads in the design of the EDS. Feasible architecture alternatives were identified from previous architecture studies and anticipated capabilities and compiled in a morphological matrix. ESAS FOMs were used to determine the most critical design attributes for the effectiveness of the EDS. The ESAS-derived FOMs used in this study to assess alternative designs are effectiveness and performance, affordability, reliability, and risk. The individual FOMs were prioritized using the AHP, a method for pairwise comparison. All trades performed were evaluated with respect to the weighted FOMs, creating a Pareto frontier of equivalently ideal solutions. Additionally, each design on the frontier was evaluated based on its fulfillment of the weighted FOMs using TOPSIS, a quantitative method for ordinal ranking of the alternatives. The designs were assessed in an integrated environment using physics-based models for subsystem analysis where possible. However, for certain attributes such as engine type, historical, performance-based mass estimating relations were more easily employed. The elements from the design process were integrated into a single loop, allowing for rapid iteration of subsystem analyses and compilation of resulting designs.

The Integration of Bacteriorhodopsin Proteins with Semiconductor Heterostructure Devices

NASA Astrophysics Data System (ADS)

Xu, Jian

2008-03-01

Bioelectronics has emerged as one of the most rapidly developing fields among the active frontiers of interdisciplinary research. A major thrust in this field is aimed at the coupling of the technologically-unmatched performance of biological systems, such as neural and sensing functions, with the well developed technology of microelectronics and optoelectronics. To this end we have studied the integration of a suitably engineered protein, bacteriorhodopsin (BR), with semiconductor optoelectronic devices and circuits. Successful integration will potentially lead to ultrasensitive sensors with polarization selectivity and built-in preprocessing capabilities that will be useful for high speed tracking, motion and edge detection, biological detection, and artificial vision systems. In this presentation we will summarize our progresses in this area, which include fundamental studies on the transient dynamics of photo-induced charge shift in BR and the coupling mechanism at protein-semiconductor interface for effective immobilizing and selectively integrating light sensitive proteins with microelectronic devices and circuits, and the device engineering of BR-transistor-integrated optical sensors as well as their applications in phototransceiver circuits. Work done in collaboration with Pallab Bhattacharya, Jonghyun Shin, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI; Robert R. Birge, Department of Chemistry, University of Connecticut, Storrs, CT 06269; and György V'ar'o, Institute of Biophysics, Biological Research Center of the Hungarian Academy of Science, H-6701 Szeged, Hungary.

The Art and Science of Systems Engineering

NASA Technical Reports Server (NTRS)

Singer, Christopher E.

2009-01-01

The National Aeronautics and Space Administration (NASA) was established in 1958, and its Marshall Space Flight Center was founded in 1960, as space-related work was transferred from the Army Ballistic Missile Agency at Redstone Arsenal, where Marshall is located. With this heritage, Marshall contributes almost 50 years of systems engineering experience with human-rated launch vehicles and scientific spacecraft to fulfill NASA's mission exploration and discovery. These complex, highly specialized systems have provided vital platforms for expanding the knowledge base about Earth, the solar system, and cosmos; developing new technologies that also benefit life on Earth; and opening new frontiers for America's strategic space goals. From Mercury and Gemini, to Apollo and the Space Shuttle, Marshall's systems engineering expertise is an unsurpassed foundational competency for NASA and the nation. Current assignments comprise managing Space Shuttle Propulsion systems; developing environmental control and life support systems and coordinating science operations on the International Space Station; and a number of exploration-related responsibilities. These include managing and performing science missions, such as the Lunar Crater Observation and Sensing Satellite and the Lunar Reconnaissance Orbiter slated to launch for the Moon in April 2009, to developing the Ares I crew launch vehicle upper stage and integrating the vehicle stack in house, as well as designing the Ares V cargo launch vehicle and contributing to the development of the Altair Lunar Lander and an International Lunar Network with communications nodes and other infrastructure.

Proceedings of the Seventh Applied Diamond Conference/Third Frontier Carbon Technology Joint Conference (ADC/FCT 2003). Supplement 1

NASA Technical Reports Server (NTRS)

Murakawa, M. (Editor); Miyoshi, K. (Editor); Koga, Y. (Editor); Schaefer, L. (Editor); Tzeng, Y. (Editor)

2003-01-01

This document contains 2 reports which were presented at the Seventh Applied Diamond Conference/Third Frontier Carbon Technology Joint Conference. The topics discuss the formation of C-N nanofibers as well as the characterization of diamond thin films.

Frontiers: Research highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-31

This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

Fermilab | Science at Fermilab | Experiments & Projects | Cosmic Frontier

Science.gov Websites

Proposed Projects and Experiments Fermilab's Tevatron Questions for the Universe Theory Computing High Answers Submit a Question Frontiers of Particle Physics Benefits to Society Benefits to Society Medicine Inquiring Minds Questions About Physics Other High-Energy Physics Sites More About Particle Physics Library

Inquiring Minds

Science.gov Websites

Go Science at Fermilab Fermilab and the Higgs Boson Frontiers of Particle Physics Experiments & Answers Submit a Question Frontiers of Particle Physics Benefits to Society Benefits to Society Medicine Inquiring Minds Questions About Physics Other High-Energy Physics Sites More About Particle Physics Library

Fermilab | Science at Fermilab | Experiments & Projects | Intensity

Science.gov Websites

Search Search Go Science at Fermilab Fermilab and the Higgs Boson Frontiers of Particle Physics and Answers Submit a Question Frontiers of Particle Physics Benefits to Society Benefits to Society Results Inquiring Minds Questions About Physics Other High-Energy Physics Sites More About Particle

Planting the Seeds: Frontiers of Justice.

ERIC Educational Resources Information Center

Mischler-Philbin, Jim; Murphy, Katie (with an introduction by Eileen Emerson)

2000-01-01

Contains articles written by two former Frontiers of Justice participants about their experiences and reflections on the legacy message of the Church in El Salvador. Also includes a poem written by the Archbishop Oscar Romero, and an extensive bibliography of resources in English on the Church in El Salvador. (VWC)

Hazardous Waste Cleanup: Frontier Chemical Waste Process Incorporated – Royal Avenue Site in Niagara Falls, New York

EPA Pesticide Factsheets

Frontier Chemical Waste Process facility is located in a heavy industrial/commercial area. Several large industrial facilities surround the facility. The closest residential area is located about ½ mile west and the closest off-site building is located 300

The Great Plains Agricultural Frontier and What Lay Ahead for Rural America.

ERIC Educational Resources Information Center

Hewitt, William L.

1988-01-01

Advocates a greater emphasis upon rural history through the study of the farming frontier. Suggests methods for introducing this topic to students. Criticizes Turner's thesis for not recognizing the extent of homesteading after 1890 and for concentrating only on agrarian settlement in the Midwest. (KO)

Frontiers: Research Highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

DOE R&D Accomplishments Database

1996-01-01

This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

Coping with the gypsy moth on new frontiers of infestation

Treesearch

David A. Gansner; Owen W. Herrick; Garland N. Mason; Kurt W. Gottschalk

1987-01-01

Forest managers on new frontiers of infestation are searching for better ways to cope with the gypsy moth (Lymantria dispar). Presented herea are information and guidelines for remedial action to minimize future losses. Methods for assessing potential stand defoliation (susceptibility) and mortality (vulnerability), monitoring insect populations, and...

Frontiers in Sociology of Education

ERIC Educational Resources Information Center

Hallinan, Maureen T., Ed.

2011-01-01

Scholarly analysis in the sociology of education has burgeoned in recent decades. "Frontiers in Sociology of Education" aims to provide a roadmap for sociologists and other social scientists as they set bold new directions for future research on schools. In Part 1 of this forward-looking volume, the authors present cutting-edge research…

Envisioning engineering education and practice in the coming intelligence convergence era — a complex adaptive systems approach

NASA Astrophysics Data System (ADS)

Noor, Ahmed K.

2013-12-01

Some of the recent attempts for improving and transforming engineering education are reviewed. The attempts aim at providing the entry level engineers with the skills needed to address the challenges of future large-scale complex systems and projects. Some of the frontier sectors and future challenges for engineers are outlined. The major characteristics of the coming intelligence convergence era (the post-information age) are identified. These include the prevalence of smart devices and environments, the widespread applications of anticipatory computing and predictive / prescriptive analytics, as well as a symbiotic relationship between humans and machines. Devices and machines will be able to learn from, and with, humans in a natural collaborative way. The recent game changers in learnscapes (learning paradigms, technologies, platforms, spaces, and environments) that can significantly impact engineering education in the coming era are identified. Among these are open educational resources, knowledge-rich classrooms, immersive interactive 3D learning, augmented reality, reverse instruction / flipped classroom, gamification, robots in the classroom, and adaptive personalized learning. Significant transformative changes in, and mass customization of, learning are envisioned to emerge from the synergistic combination of the game changers and other technologies. The realization of the aforementioned vision requires the development of a new multidisciplinary framework of emergent engineering for relating innovation, complexity and cybernetics, within the future learning environments. The framework can be used to treat engineering education as a complex adaptive system, with dynamically interacting and communicating components (instructors, individual, small, and large groups of learners). The emergent behavior resulting from the interactions can produce progressively better, and continuously improving, learning environment. As a first step towards the realization of the vision, intelligent adaptive cyber-physical ecosystems need to be developed to facilitate collaboration between the various stakeholders of engineering education, and to accelerate the development of a skilled engineering workforce. The major components of the ecosystems include integrated knowledge discovery and exploitation facilities, blended learning and research spaces, novel ultra-intelligent software agents, multimodal and autonomous interfaces, and networked cognitive and tele-presence robots.

Biofuels. Engineering alcohol tolerance in yeast.

PubMed

Lam, Felix H; Ghaderi, Adel; Fink, Gerald R; Stephanopoulos, Gregory

2014-10-03

Ethanol toxicity in the yeast Saccharomyces cerevisiae limits titer and productivity in the industrial production of transportation bioethanol. We show that strengthening the opposing potassium and proton electrochemical membrane gradients is a mechanism that enhances general resistance to multiple alcohols. The elevation of extracellular potassium and pH physically bolsters these gradients, increasing tolerance to higher alcohols and ethanol fermentation in commercial and laboratory strains (including a xylose-fermenting strain) under industrial-like conditions. Production per cell remains largely unchanged, with improvements deriving from heightened population viability. Likewise, up-regulation of the potassium and proton pumps in the laboratory strain enhances performance to levels exceeding those of industrial strains. Although genetically complex, alcohol tolerance can thus be dominated by a single cellular process, one controlled by a major physicochemical component but amenable to biological augmentation. Copyright © 2014, American Association for the Advancement of Science.

Study of activation data of metal samples from LDEF-1 and Spacelab-2

NASA Technical Reports Server (NTRS)

Laird, C. E.

1994-01-01

Gamma-ray spectra obtained from samples flown aboard the Long Duration Exposure Facility have been analyzed to obtain the nuclear species produced in this material by the interaction of this material with protons and neutrons in this material by the interaction of this material with protons and neutrons encountered in its 69 month orbital flight as well as to quantify the specific activity (pCi/kg) of these nuclear species. This quantification requires accurate corrections of efficiency, self-attenuation, and background. Plans have been developed for archival of the spectra in a form readily accessible to the scientific, engineering and technical community engaged in space research and application. Work has been initiated in the process of estimating the flux of activating particles encountered by material at various locations of the spacecraft.

Safety assessment for EPS electron-proton spectrometer

NASA Technical Reports Server (NTRS)

Gleeson, P.

1971-01-01

A safety analysis was conducted to identify the efforts required to assure relatively hazard free operation of the EPS and to meet the safety requirements of the program. Safety engineering criteria, principles, and techniques in applicable disciplines are stressed in the performance of the system and subsystem studies; in test planning; in the design, development, test, evaluation, and checkout of the equipment; and the operating procedures for the EPS program.

Astronaut Susan J. Helms Mounts a Videao Camera in Zarya

NASA Technical Reports Server (NTRS)

2001-01-01

Astronaut Susan J. Helms, Expedition Two flight engineer, mounts a video camera onto a bracket in the Russian Zarya or Functional Cargo Block (FGB) of the International Space Station (ISS). Launched by a Russian Proton rocket from the Baikonu Cosmodrome on November 20, 1998, the Unites States-funded and Russian-built Zarya was the first element of the ISS, followed by the U.S. Unity Node.

Sub-second pencil beam dose calculation on GPU for adaptive proton therapy.

PubMed

da Silva, Joakim; Ansorge, Richard; Jena, Rajesh

2015-06-21

Although proton therapy delivered using scanned pencil beams has the potential to produce better dose conformity than conventional radiotherapy, the created dose distributions are more sensitive to anatomical changes and patient motion. Therefore, the introduction of adaptive treatment techniques where the dose can be monitored as it is being delivered is highly desirable. We present a GPU-based dose calculation engine relying on the widely used pencil beam algorithm, developed for on-line dose calculation. The calculation engine was implemented from scratch, with each step of the algorithm parallelized and adapted to run efficiently on the GPU architecture. To ensure fast calculation, it employs several application-specific modifications and simplifications, and a fast scatter-based implementation of the computationally expensive kernel superposition step. The calculation time for a skull base treatment plan using two beam directions was 0.22 s on an Nvidia Tesla K40 GPU, whereas a test case of a cubic target in water from the literature took 0.14 s to calculate. The accuracy of the patient dose distributions was assessed by calculating the γ-index with respect to a gold standard Monte Carlo simulation. The passing rates were 99.2% and 96.7%, respectively, for the 3%/3 mm and 2%/2 mm criteria, matching those produced by a clinical treatment planning system.

The role of community health centers in assessing the social determinants of health for planning and policy: the example of frontier New Mexico.

PubMed

Bruna, Sean; Stone, Lisa Cacari; Wilger, Susan; Cantor, Jeremy; Guzman, Carolina

2014-01-01

This article examines the experience of a frontier-based community health center when it utilized the Tool for Health and Resilience in Vulnerable Environments (THRIVE) for assessing social determinants of health with a local health consortium. Community members (N = 357) rated safety, jobs, housing, and education among the top health issues. Community leaders integrated these health priorities in a countywide strategic planning process. This example of a frontier county in New Mexico demonstrates the critical role that community health centers play when engaging with local residents to assess community health needs for strategic planning and policy development.

Apparatus for Ultrahigh Precision Measurement of 13 S1 - 23S 1 Interval in Positronium

NASA Astrophysics Data System (ADS)

Goldman, Harris J.

Positronium (Ps) is a purely leptonic atom comprising an electron and its antimatter equivalent, the positron, in a quasi-stable bound state. Due to its fundamental nature, Ps is an ideal test bed for bound-state QED. Recent high-precision spectroscopic experiments reveal a discrepancy in the measurement of the proton charge radius rp, known as the Proton Charge Radius Puzzle. Spectroscopic measurments carried out on hydrogen and muonic hydrogen, the bound state of a muon and a proton, differ from other scattering and other spectroscopic experiments by 3.3sigma. The measurement of rp comes from fitting the resulting measurement of either the 1S-2S interval of hydrogen or the Lamb Shift in muonic hydrogen to theory. Neither of these atoms are governed purely by quantum electrodynamics (QED) alone as nuclear structure has a role to play. The ratio of the masses of the orbiting particle m to that of the nucleus M is a coefficient in a number of a QED corrections to the energy levels of hydrogen (m/M = 1/1836) and muonic hydrogen ( m/M = 207/1836) and reveals the importance of performing a complementary spectroscopic measurement in Ps, where m/M = 1. The last measurement of the 1S-2S interval was carried out by Fee, Chu, Mills, et al. in 1993 to a precision of 3.2 ppb. The state-of-the-art measurement on hydrogen is now at an uncertainty of 4.2 x 10-15. While the simplicity of Ps causes it to be appealing to test bound-state QED, its antiparticle-particle nature makes it difficult to work with: the ground state lifetime of the triplet state is 142 ns, and whereas the 2S lifetime in Ps is 1.14 micros, the 2S lifetime in hydrogen is 105x longer. We have designed and constructed an apparatus and experiment to measure the 1S-2S interval in Ps at precision levels that we expect to immediately improve upon the previous measurements by factor of 2x and pave the way for ultimate comparison to the hydrogenic measurements. The apparatus also opens the doors to a new frontier in high-precision spectroscopy: the sub-micros regime.

Frontiers in Laser Cooling, Single-Molecule Biophysics, and Energy Science: A Talk from Eric Cornell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cornell, Eric

2008-08-30

Eric Cornell presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

Frontiers in Laser Cooling, Single-Molecule Biophysics, and Energy Science: A Talk from Kurt Gibble

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibble, Kurt

2008-08-30

Kurt Gibble presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

Frontiers in Laser Cooling, Single-Molecule Biophysics, and Energy Science: A Talk from Jay Keasling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keasling, Jay

2008-08-30

Jay Keasling presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

Frontiers in Laser Cooling, Single-Molecule Biophysics, and Enrgy Science: A Talk by Carl Wieman

ScienceCinema

Wieman, Carl

2017-12-09

Carl Wieman presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

Stroke Knowledge among Urban and Frontier First Responders and Emergency Medical Technicians in Montana

ERIC Educational Resources Information Center

McNamara, Michael J.; Oser, Carrie; Gohdes, Dorothy; Fogle, Crystelle C.; Dietrich, Dennis W.; Burnett, Anne; Okon, Nicholas; Russell, Joseph A.; DeTienne, James; Harwell, Todd S.; Helgerson, Steven D.

2008-01-01

Purpose: To assess stroke knowledge and practice among frontier and urban emergency medical services (EMS) providers and to evaluate the need for additional prehospital stroke training opportunities in Montana. Methods: In 2006, a telephone survey of a representative sample of EMS providers was conducted in Montana. Respondents were stratified…

Stochastic Frontier Estimation of Efficient Learning in Video Games

ERIC Educational Resources Information Center

Hamlen, Karla R.

2012-01-01

Stochastic Frontier Regression Analysis was used to investigate strategies and skills that are associated with the minimization of time required to achieve proficiency in video games among students in grades four and five. Students self-reported their video game play habits, including strategies and skills used to become good at the video games…