Use of nonlinear design optimization techniques in the comparison of battery discharger topologies for the space platform

NASA Technical Reports Server (NTRS)

Sable, Dan M.; Cho, Bo H.; Lee, Fred C.

1990-01-01

A detailed comparison of a boost converter, a voltage-fed, autotransformer converter, and a multimodule boost converter, designed specifically for the space platform battery discharger, is performed. Computer-based nonlinear optimization techniques are used to facilitate an objective comparison. The multimodule boost converter is shown to be the optimum topology at all efficiencies. The margin is greatest at 97 percent efficiency. The multimodule, multiphase boost converter combines the advantages of high efficiency, light weight, and ample margin on the component stresses, thus ensuring high reliability.

Changes in the central nervous system during long-duration space flight: implications for neuro-imaging

NASA Astrophysics Data System (ADS)

Newberg, A. B.; Alavi, A.

The purpose of this paper is to review the potential functional and morphological effects of long duration space flight on the human central nervous system (CNS) and how current neuroimaging techniques may be utilized to study these effects. It must be determined if there will be any detrimental changes to the CNS from long term exposure to the space environment if human beings are to plan interplanetary missions or establish permanent space habitats. Research to date has focused primarily on the short term changes in the CNS as the result of space flight. The space environment has many factors such as weightlessness, electromagnetic fields, and radiation, that may impact upon the function and structure of the CNS. CNS changes known to occur during and after long term space flight include neurovestibular disturbances, cephalic fluid shifts, alterations in sensory perception, changes in proprioception, psychological disturbances, and cognitive changes. Animal studies have shown altered plasticity of the neural cytoarchitecture, decreased neuronal metabolism in the hypothalamus, and changes in neurotransmitter concentrations. Recent progress in the ability to study brain morphology, cerebral metabolism, and neurochemistry in vivo in the human brain would provide ample opportunity to investigate many of the changes that occur in the CNS as a result of space flight. These methods include positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI).

A cost engineered launch vehicle for space tourism

NASA Astrophysics Data System (ADS)

Koelle, -Ing. Dietrich E., , Dr.

1999-09-01

The paper starts with a set of major requirements for a space tourism vehicle and discusses major vehicle options proposed for this purpose. It seems that the requirements can be met best with a Ballistic SSTO Vehicle which has the additional advantage of lowest development cost compared to other launch vehicle options — important for a commercial development venture. The BETA Ballistic Reusable Vehicle Concept is characterized by the plug nozzle cluster engine configuration where the plug nozzle serves also as base plate and re-entry heat shield. In this case no athmospheric turn maneuver is required (as in case-of the front-entry Delta-Clipper DC-Y concept). In our specific case for space tourism this mode has the avantage that the forces at launch and reentry are in exactly the same direction, easing passenger seating arrangements. The second basic advantage is the large available volume on top of the vehicle providing ample space for passenger accomodation, visibility and volume for zero-g experience (free floating), one of the major passenger mission requirements. An adequate passenger cabin design for 100 passengers is presented, as well as the modern BETA-STV Concept with its mass allocations.

Data from the Arizona FACE (Free-Air CO2 Enrichment) experiments on wheat at ample and limiting levels of water and nitrogen

USDA-ARS?s Scientific Manuscript database

Four free-air CO2 enrichment (FACE) experiments were conducted on wheat (Triticum aestivum L. cv. Yecora Rojo) at Maricopa, Arizona, U.S.A. from December, 1992 through May, 1997. The first two were conducted at ample and limited (50% of ample) supplies of water, and second two at ample (350 kg N ha-...

Infrared Astrophysics in the SOFIA Era - An Overview

NASA Astrophysics Data System (ADS)

Yorke, Harold W.

2018-06-01

The Stratospheric Observatory for Infrared Astronomy (SOFIA) provides the international astronomical community access to a broad range of instrumentation that covers wavelengths spanning the near to far infrared. The high spectral resolution of many of these instruments in several wavelength bands is unmatched by any existing or near future planned facility. The far infrared polarization capabilities of one of its instruments, HAWC+, is also unique. Moreover, SOFIA allows for additional instrument augmentations, as new state-of-the-art photometric, spectrometric, and polarimetric capabilities have been added and are being further improved. The fact that SOFIA provides ample mass, power, computing capabilities as well as 4K cooling eases the constraints on future instrument design, technical readiness, and the instrument build to an extent not possible for space-borne missions. We will review SOFIA's current and future planned capabilities and highlight specific science areas for which the stratospheric observatory will be able to significantly advance Origins science topics.

Evolution of space drones for planetary exploration: A review

NASA Astrophysics Data System (ADS)

Hassanalian, M.; Rice, D.; Abdelkefi, A.

2018-02-01

In the past decade, there has been a tendency to design and fabricate drones which can perform planetary exploration. Generally, there are various ways to study space objects, such as the application of telescopes and satellites, launching robots and rovers, and sending astronauts to the targeted solar bodies. However, due to the advantages of drones compared to other approaches in planetary exploration, ample research has been carried out by different space agencies in the world, including NASA to apply drones in other solar bodies. In this review paper, several studies which have been performed on space drones for planetary exploration are consolidated and discussed. Design and fabrication challenges of space drones, existing methods for their flight tests, different methods for deployment and planet entry, and various navigation and control approaches are reviewed and discussed elaborately. Limitations of applying space drones, proposed solutions for future space drones, and recommendations are also presented and discussed.

Proceedings of the Conference on Chemical Risk Assessment in the DoD: science, Policy, and Practice Held in Dayton, Ohio on April 8-11, 1991

DTIC Science & Technology

1993-01-01

eroforom their craft and trades." Ranmzini describes the prin- ample, doe odds are one in a billion that a person ciplecaus as: will die from cancer by...birth of mden quanitative risk assessment can be Our coimuiy’s entry into the " space race" stimulated Ix x Chemick Risk Asessment interest in the...health effects of continuous exposures to space - to the chemical or material in the specific situation of concern; cabin environments. In response to this

Summary: achievements, critical issues, and thoughts on the future.

PubMed

Held, Kathryn D

2012-11-01

The number of individuals exposed to particle radiations in cancer treatment worldwide is increasing rapidly, and space agencies are developing plans for long duration, deep space missions in which humans could be exposed to significant levels of radiation from charged particles. Hence, the NCRP 47 th Annual Meeting on "Scientific and Policy Challenges of Particle Radiations in Medical Therapy and Space Missions" was a timely opportunity to showcase the current scientific knowledge regarding charged particles, enhance cross-fertilization between the oncology and space scientific communities, and identify common needs and challenges to both communities as well as ways to address those challenges. This issue of Health Physics contains papers from talks presented at that meeting and highlights provocative questions and the ample opportunities for synergism between space and particle-therapy research to further understanding of the biological impacts of particle radiations.

NPS-SCAT CONOPS and Radiation Environment

DTIC Science & Technology

2012-06-01

flexibility, as well as allows players in the space market who would otherwise not be able to enter due to budgetary limitations. Important to NPS is...commercial market . Although the time frame for completing NPS-SCAT has not been as short as possible due to the nature of the learning environment on its...Program ( STP ) seeks flight opportunities for approved experiments. The current NPS- SCAT launch date offers ample time to finish and test the

Faucets Specification and Certification

EPA Pesticide Factsheets

Faucets and faucet accessories—products that can be attached easily to existing faucets to save water—that obtain the WaterSense label have demonstrated both water efficiency and the ability to provide ample flow.

Your Yard Can Be Greener

EPA Pesticide Factsheets

Home and business owners can look for the WaterSense label on products such as irrigation system controllers and know that the technology will provide ample water for healthy plant growth without overwatering.

Mass loading of the Earth's magnetosphere by micron size lunar ejecta. 1: Ejecta production and orbital dynamics in cislunar space

NASA Technical Reports Server (NTRS)

Alexander, W. M.; Tanner, W. G.; Anz, P. D.; Chen, A. L.

1986-01-01

Particulate matter possessing lunar escape velocity sufficient to enhance the cislunar meteroid flux was investigated. While the interplanetary flux was extensively studied, lunar ejecta created by the impact of this material on the lunar surface is only now being studied. Two recently reported flux models are employed to calculate the total mass impacting the lunar surface due to sporadic meteor flux. There is ample evidence to support the contention that the sporadic interplanetary meteoroid flux enhances the meteroid flux of cislunar space through the creation of micron and submicron lunar ejecta with lunar escape velocity.

The role of the space station in earth science research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaye, Jack A.

1999-01-22

The International Space Station (ISS) has the potential to be a valuable platform for earth science research. By virtue of its being in a mid-inclination orbit (51.5 deg.), ISS provides the opportunity for nadir viewing of nearly 3/4 of the Earth's surface, and allows viewing to high latitudes if limb-emission or occultation viewing techniques are used. ISS also provides the opportunity for viewing the Earth under a range of lighting conditions, unlike the polar sun-synchronous satellites that are used for many earth observing programs. The ISS is expected to have ample power and data handling capability to support Earth-viewing instruments,more » provide opportunities for external mounting and retrieval of instruments, and be in place for a sufficiently long period that long-term data records can be obtained. On the other hand, there are several questions related to contamination, orbital variations, pointing knowledge and stability, and viewing that are of concern in consideration of ISS for earth science applications. The existence of an optical quality window (the Window Observational Research Facility, or WORF), also provides the opportunity for Earth observations from inside the pressurized part of ISS. Current plans by NASA for earth science research from ISS are built around the Stratospheric Aerosol and Gas Experiment (SAGE III) instrument, planned for launch in 2002.« less

M ssbauer spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hermann, Raphael P

2017-01-01

This most comprehensive and unrivaled compendium in the field provides an up-to-date account of the chemistry of solids, nanoparticles and hybrid materials. Following a valuable introductory chapter reviewing important synthesis techniques, the handbook presents a series of contributions by about 150 international leading experts -- the "Who's Who" of solid state science. Clearly structured, in six volumes it collates the knowledge available on solid state chemistry, starting from the synthesis, and modern methods of structure determination. Understanding and measuring the physical properties of bulk solids and the theoretical basis of modern computational treatments of solids are given ample space, asmore » are such modern trends as nanoparticles, surface properties and heterogeneous catalysis. Emphasis is placed throughout not only on the design and structure of solids but also on practical applications of these novel materials in real chemical situations.« less

Contingency Planning for the Microwave Anisotropy Probe Mission

NASA Technical Reports Server (NTRS)

Mesarch, Michael A.; Rohrbaugh, David; Schiff, Conrad; Bauer, Frank (Technical Monitor)

2002-01-01

The Microwave Anisotropy Probe (MAP) utilized a phasing loop/lunar encounter strategy to achieve a small amplitude Lissajous orbit about the Sun-Earth/Moon L2 libration point. The use of phasing loops was key in minimizing MAP's overall deltaV needs while also providing ample opportunities for contingency resolution. This paper will discuss the different contingencies and responses studied for MAP. These contingencies included accommodating excessive launch vehicle errors (beyond 3 sigma), splitting perigee maneuvers to achieve ground station coverage through the Deep Space Network (DSN), delaying the start of a perigee maneuver, aborting a perigee maneuver in the middle of execution, missing a perigee maneuver altogether, and missing the lunar encounter (crucial to achieving the final Lissajous orbit). It is determined that using a phasing loop approach permits many opportunities to correct for a majority of these contingencies.

On the Automorphisms of a Rank One Deligne-Hitchin Moduli Space

NASA Astrophysics Data System (ADS)

Biswas, Indranil; Heller, Sebastian

2017-09-01

Let X be a compact connected Riemann surface of genus g ≥ 2, and let M_{DH} be the rank one Deligne-Hitchin moduli space associated to X. It is known that M_{DH} is the twistor space for the hyper-Kähler structure on the moduli space of rank one holomorphic connections on X. We investigate the group \\operatorname{Aut}(M_{DH}) of all holomorphic automorphisms of M_{DH}. The connected component of \\operatorname{Aut}(M_{DH}) containing the identity automorphism is computed. There is a natural element of H^2(M_{DH}, Z). We also compute the subgroup of \\operatorname{Aut}(M_{DH}) that fixes this second cohomology class. Since M_{DH} admits an ample rational curve, the notion of algebraic dimension extends to it by a theorem of Verbitsky. We prove that M_{DH} is Moishezon.

Exploring the speed and performance of molecular replacement with AMPLE using QUARK ab initio protein models.

PubMed

Keegan, Ronan M; Bibby, Jaclyn; Thomas, Jens; Xu, Dong; Zhang, Yang; Mayans, Olga; Winn, Martyn D; Rigden, Daniel J

2015-02-01

AMPLE clusters and truncates ab initio protein structure predictions, producing search models for molecular replacement. Here, an interesting degree of complementarity is shown between targets solved using the different ab initio modelling programs QUARK and ROSETTA. Search models derived from either program collectively solve almost all of the all-helical targets in the test set. Initial solutions produced by Phaser after only 5 min perform surprisingly well, improving the prospects for in situ structure solution by AMPLE during synchrotron visits. Taken together, the results show the potential for AMPLE to run more quickly and successfully solve more targets than previously suspected.

Molecular Evolution of Human PON to Design Enhanced Catalytic Efficiency for Hydrolysis of Nerve Agents

DTIC Science & Technology

2010-02-01

REPORT DATE: February 2010 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort...NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) US Army Medical Research and Material Command Fort Detrick, Maryland 21702-5012 11...that the imidazole ring is mobile , and that there is ample free space to accommodation the corresponding conformers (Fig. 6A) 2. The movement of the

Puncture Self-Healing Polymers for Aerospace Applications

NASA Technical Reports Server (NTRS)

Gordon, Keith L.; Penner, Ronald K.; Bogert, Phil B.; Yost, W. T.; Siochi, Emilie J.

2011-01-01

Space exploration launch costs on the order of $10K per pound provide ample incentive to seek innovative, cost-effective ways to reduce structural mass without sacrificing safety and reliability. Damage-tolerant structural systems can provide a route to avoiding weight penalty while enhancing vehicle safety and reliability. Self-healing polymers capable of spontaneous puncture repair show great promise to mitigate potentially catastrophic damage from events such as micrometeoroid penetration. Effective self-repair requires these materials to heal instantaneously following projectile penetration while retaining structural integrity. Poly(ethylene-co-methacrylic acid) (EMMA), also known as Surlyn is an ionomer-based copolymer that undergoes puncture reversal (self-healing) following high impact puncture at high velocities. However EMMA is not a structural engineering polymer, and will not meet the demands of aerospace applications requiring self-healing engineering materials. Current efforts to identify candidate self-healing polymer materials for structural engineering systems are reported. Rheology, high speed thermography, and high speed video for self-healing semi-crystalline and amorphous polymers will be reported.

Silicon quantum processor with robust long-distance qubit couplings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tosi, Guilherme; Mohiyaddin, Fahd A.; Schmitt, Vivien

Practical quantum computers require a large network of highly coherent qubits, interconnected in a design robust against errors. Donor spins in silicon provide state-of-the-art coherence and quantum gate fidelities, in a platform adapted from industrial semiconductor processing. Here we present a scalable design for a silicon quantum processor that does not require precise donor placement and leaves ample space for the routing of interconnects and readout devices. We introduce the flip-flop qubit, a combination of the electron-nuclear spin states of a phosphorus donor that can be controlled by microwave electric fields. Two-qubit gates exploit a second-order electric dipole-dipole interaction, allowingmore » selective coupling beyond the nearest-neighbor, at separations of hundreds of nanometers, while microwave resonators can extend the entanglement to macroscopic distances. We predict gate fidelities within fault-tolerance thresholds using realistic noise models. This design provides a realizable blueprint for scalable spin-based quantum computers in silicon.« less

Connecting with New Social Movements

ERIC Educational Resources Information Center

Lavender, Peter

2005-01-01

In this article, the author discusses the emergence of unions and social movements which provide opportunities for adult educators in forwarding their adult literacy campaigns. The author describes the recent World Social Forum (WSF), held at the end of January in Porto Alegre, that provides ample opportunities for adult educators to make…

Space Science in the Kindergarten Classroom and Beyond

NASA Astrophysics Data System (ADS)

Bonett, D.

2000-12-01

With the advent of probes to our closest planet Mars and the multi-national construction of Earth's first International Space Station, it is not presumptive to introduce 5 year old school children to the space sciences. K. E. Little Elementary School is located in the community of Bacliff, Texas. It is the largest elementary school (950 students) in the Dickinson Independent School District. K. E. Little is a Title 1 school with a multi-ethnic student population. It's close proximity to the Johnson Space Center and the Lunar and Planetary Institute provide ample instructional support and material. Last fall, two kindergarten classes received space science instruction. Both were class sizes of 19 with one class predominantly children of Vietnamese immigrants. Our goal was to create curiosity and awareness through a year-long integrated space science program of instruction. Accurate information of the space sciences was conveyed through sources i.e. books and videos, as well as conventional song, movement, and artistic expression. Videotaping and photographs replaced traditional anecdotal records. Samples of student work were compiled for classroom and school display. This year, two fifth grade classes will receive space science instruction using the Jason Project XII curriculum. Students will engage in a year-long exploration of the Hawaiian Islands. Information will be conveyed via internet and live video presentations as well as traditional sources i.e. books and videos, as well as song, movement, and artistic expression. Comparison of volcanic activity in Hawaii to volcanoes on other planets will be one of several interplanetary correlations. Samples of student work will be compiled for classroom, school, and community display.

Exploring the speed and performance of molecular replacement with AMPLE using QUARK ab initio protein models

PubMed Central

Keegan, Ronan M.; Bibby, Jaclyn; Thomas, Jens; Xu, Dong; Zhang, Yang; Mayans, Olga; Winn, Martyn D.; Rigden, Daniel J.

2015-01-01

AMPLE clusters and truncates ab initio protein structure predictions, producing search models for molecular replacement. Here, an interesting degree of complementarity is shown between targets solved using the different ab initio modelling programs QUARK and ROSETTA. Search models derived from either program collectively solve almost all of the all-helical targets in the test set. Initial solutions produced by Phaser after only 5 min perform surprisingly well, improving the prospects for in situ structure solution by AMPLE during synchrotron visits. Taken together, the results show the potential for AMPLE to run more quickly and successfully solve more targets than previously suspected. PMID:25664744

Acid Rain: A Teaching Focus for the Intermediate Grades.

ERIC Educational Resources Information Center

Adams, Renee B.; Adams, Neil D.

1992-01-01

The study of acid rain provides ample opportunities for active, interdisciplinary learning. This article describes 12 hands-on activities designed to expand students' understanding of acid rain. Background information on acid rain is included. (LB)

A space imaging concept based on a 4m structured spun-cast borosilicate monolithic primary mirror

NASA Astrophysics Data System (ADS)

West, S. C.; Bailey, S. H.; Bauman, S.; Cuerden, B.; Granger, Z.; Olbert, B. H.

2010-07-01

Lockheed Martin Corporation (LMC) tasked The University of Arizona Steward Observatory (UASO) to conduct an engineering study to examine the feasibility of creating a 4m space telescope based on mature borosilicate technology developed at the UASO for ground-based telescopes. UASO has completed this study and concluded that existing launch vehicles can deliver a 4m monolithic telescope system to a 500 km circular orbit and provide reliable imagery at NIIRS 7-8. An analysis of such an imager based on a lightweight, high-performance, structured 4m primary mirror cast from borosilicate glass is described. The relatively high CTE of this glass is used to advantage by maintaining mirror shape quality with a thermal figuring method. Placed in a 290 K thermal shroud (similar to the Hubble Space Telescope), the orbit averaged figure surface error is 6nm rms when earth-looking. Space-looking optical performance shows that a similar thermal conditioning scheme combined with a 270 K shroud achieves primary mirror distortion of 10 nm rms surface. Analysis shows that a 3-point bipod mount will provide launch survivability with ample margin. The primary mirror naturally maintains its shape at 1g allowing excellent end-to-end pre-launch testing with e.g. the LOTIS 6.5m Collimator. The telescope includes simple systems to measure and correct mirror shape and alignment errors incorporating technologies already proven on the LOTIS Collimator. We have sketched a notional earth-looking 4m telescope concept combined with a wide field TMA concept into a DELTA IV or ATLAS 552 EELV fairing. We have combined an initial analysis of launch and space performance of a special light-weighted honeycomb borosilicate mirror (areal density 95 kg/m2) with public domain information on the existing launch vehicles.

Structural Analyses of Stirling Power Convertor Heater Head for Long-Term Reliability, Durability, and Performance

NASA Technical Reports Server (NTRS)

Halford, Gary R.; Shah, Ashwin; Arya, Vinod K.; Krause, David L.; Bartolotta, Paul A.

2002-01-01

Deep-space missions require onboard electric power systems with reliable design lifetimes of up to 10 yr and beyond. A high-efficiency Stirling radioisotope power system is a likely candidate for future deep-space missions and Mars rover applications. To ensure ample durability, the structurally critical heater head of the Stirling power convertor has undergone extensive computational analyses of operating temperatures (up to 650 C), stresses, and creep resistance of the thin-walled Inconel 718 bill of material. Durability predictions are presented in terms of the probability of survival. A benchmark structural testing program has commenced to support the analyses. This report presents the current status of durability assessments.

Attributes of Effective Mentoring Relationships for Novice Faculty Members: Perspectives of Mentors and Mentees

ERIC Educational Resources Information Center

Barrett, Jessica L.; Mazerolle, Stephanie M.; Nottingham, Sara L.

2017-01-01

Context: Although doctoral education provides ample opportunities for skill development, the new faculty member may still require further support and guidance. Mentorship is often the mechanism whereby continued encouragement is provided. Limited understanding exists of the mentoring relationships developed between a new faculty member and a…

HAZARDS OF THERMAL EXPANSION FOR RADIOLOGICAL CONTAINER ENGULFED IN FIRE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donna Post Guillen

2013-05-01

Fire accidents pose a serious threat to nuclear facilities. It is imperative that transport casks or shielded containers designed to transport/contain radiological materials have the ability to withstand a hypothetical fire. A numerical simulation was performed for a shielded container constructed of stainless steel and lead engulfed in a hypothetical fire as outlined by 10 CFR §71.73. The purpose of this analysis was to determine the thermal response of the container during and after the fire. The thermal model shows that after 30 minutes of fire, the stainless steel will maintain its integrity and not melt. However, the lead shieldingmore » will melt since its temperature exceeds the melting point. Due to the method of construction of the container under consideration, ample void space must be provided to allow for thermal expansion of the lead upon heating and melting, so as to not overstress the weldment.« less

Plant centromere organization: a dynamic structure with conserved functions.

PubMed

Ma, Jianxin; Wing, Rod A; Bennetzen, Jeffrey L; Jackson, Scott A

2007-03-01

Although the structural features of centromeres from most multicellular eukaryotes remain to be characterized, recent analyses of the complete sequences of two centromeric regions of rice, together with data from Arabidopsis thaliana and maize, have illuminated the considerable size variation and sequence divergence of plant centromeres. Despite the severe suppression of meiotic chromosomal exchange in centromeric and pericentromeric regions of rice, the centromere core shows high rates of unequal homologous recombination in the absence of chromosomal exchange, resulting in frequent and extensive DNA rearrangement. Not only is the sequence of centromeric tandem and non-tandem repeats highly variable but also the copy number, spacing, order and orientation, providing ample natural variation as the basis for selection of superior centromere performance. This review article focuses on the structural and evolutionary dynamics of plant centromere organization and the potential molecular mechanisms responsible for the rapid changes of centromeric components.

Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis†

PubMed Central

Huang, Min; Xie, Sheng-Xue; Ma, Ze-Qiang; Huang, Qing-Qing; Nan, Fa-Jun; Ye, Qi-Zhuang

2008-01-01

Two divalent metal ions are commonly seen in the active site cavity of methionine aminopeptidase, and at least one of the metal ions is directly involved in catalysis. Although ample structural and functional information is available for dimetalated enzyme, methionine aminopeptidase likely functions as a monometalated enzyme under physiological conditions. Information on structure, as well as catalysis and inhibition, of the monometalated enzyme is lacking. By improving conditions of high throughput screening, we identified a unique inhibitor with specificity toward the monometalated enzyme. Kinetic characterization indicates a mutual exclusivity in binding between the inhibitor and the second metal ion at the active site. This is confirmed by X-ray structure, and this inhibitor coordinates with the first metal ion and occupies the space normally occupied by the second metal ion. Kinetic and structural analyses of the inhibition by this and other inhibitors provide insight in designing effective inhibitors of methionine aminopeptidase. PMID:17948983

Geographic Variation of Eastern White Pine in the Northeast

Treesearch

Peter W. Garrett; Ernst J. Schreiner; Harry Kettlewood

1973-01-01

Eastern white pine is the most valuable conifer in the Northeast, and its large botanical range has provided ample opportunity for the development of ecotypes. Provenance plantings in nine states provided information on variability within the species and recommendations for moving seed from one region to another. Good growth was obtained on southern Appalachian sources...

Acting Like Rain

ERIC Educational Resources Information Center

Baldwin, Kathryn; Wilson, Allison

2017-01-01

Having high-quality early childhood education programs that prepare children for success in school and later years continues to be an ever increasing national priority. While the "Next Generation Science Standards" ("NGSS") do not provide standards for preschool, there are ample opportunities to use the Standards as a guide to…

Models as Relational Categories

ERIC Educational Resources Information Center

Kokkonen, Tommi

2017-01-01

Model-based learning (MBL) has an established position within science education. It has been found to enhance conceptual understanding and provide a way for engaging students in authentic scientific activity. Despite ample research, few studies have examined the cognitive processes regarding learning scientific concepts within MBL. On the other…

Film-Making as a School Activity.

ERIC Educational Resources Information Center

Beal, J. David

1969-01-01

Fiction film production--begun several years ago to stimulate the participation of all students in dramatic and creative activities--has become a vital part of a school program, involving project organization and interdepartmental cooperation. The English department initiates the project, which provides ample opportunities for promoting linguistic…

PDB to AMPL Conversion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anna Johnston, SNL 9215

2002-09-01

PDB to AMPL Conversion was written to convert protein data base files to AMPL files. The protein data bases on the internet contain a wealth of information about the structue and makeup of proteins. Each file contains information derived by one or more experiments and contains information on how the experiment waw performed, the amino acid building blocks of each chain, and often the three-dimensional structure of the protein extracted from the experiments. The way a protein folds determines much about its function. Thus, studying the three-dimensional structure of the protein is of great interest. Analysing the contact maps ismore » one way to examine the structure. A contact map is a graph which has a linear back bone of amino acids for nodes (i.e., adjacent amino acids are always connected) and vertices between non-adjacent nodes if they are close enough to be considered in contact. If the graphs are similar then the folds of the protein and their function should also be similar. This software extracts the contact maps from a protein data base file and puts in into AMPL data format. This format is designed for use in AMPL, a programming language for simplifying linear programming formulations.« less

Thin Film Technology Development for the Powersphere

NASA Technical Reports Server (NTRS)

Simburger, Edward J.; Matsumoto, James H.; Giants, Thomas W.; Garcia, Alexander, III; Liu, Simon; Rawal, Suraj P.; Perry, Alan R.; Marshall, Craig H.; Lin, John K.; Scarborough, Stephen;

Time drawings: Spatial representation of temporal concepts.

PubMed

Leone, María Juliana; Salles, Alejo; Pulver, Alejandro; Golombek, Diego Andrés; Sigman, Mariano

2018-03-01

Time representation is a fundamental property of human cognition. Ample evidence shows that time (and numbers) are represented in space. However, how the conceptual mapping varies across individuals, scales, and temporal structures remains largely unknown. To investigate this issue, we conducted a large online study consisting in five experiments that addressed different time scales and topology: Zones of time, Seasons, Days of the week, Parts of the day and Timeline. Participants were asked to map different kinds of time events to a location in space and to determine their size and color. Results showed that time is organized in space in a hierarchical progression: some features appear to be universal (i.e. selection order), others are shaped by how time is organized in distinct cultures (i.e. location order) and, finally, some aspects vary depending on individual features such as age, gender, and chronotype (i.e. size and color). Copyright © 2018 Elsevier Inc. All rights reserved.

Algebraic Thinking through Koch Snowflake Constructions

ERIC Educational Resources Information Center

Ghosh, Jonaki B.

2016-01-01

Generalizing is a foundational mathematical practice for the algebra classroom. It entails an act of abstraction and forms the core of algebraic thinking. Kinach (2014) describes two kinds of generalization--by analogy and by extension. This article illustrates how exploration of fractals provides ample opportunity for generalizations of both…

Technical Education and Vocational Training in Developing Nations

ERIC Educational Resources Information Center

Okolie, Ugochukwu Chinonso, Ed.

2017-01-01

Severe economic depression and the difficulty to acquire employment with adequate income have significant impact on a nation's social welfare. The need to provide ample educational opportunities is more imperative than ever, particularly in emerging economies. "Technical Education and Vocational Training in Developing Nations" is a…

Sustaining Students' Reading Comprehension

ERIC Educational Resources Information Center

Mariotti, Arleen P.

2010-01-01

Extensive research over the years indicates that there are at least five essential components teachers can include in their classroom to help their students comprehend and learn. These features include: (1) giving background and connecting to students' prior knowledge; (2) providing a strong vocabulary program; (3) setting aside ample opportunity…

9 CFR 3.102 - Facilities, indoor.

Code of Federal Regulations, 2011 CFR

2011-01-01

... be ventilated by natural or artificial means to provide a flow of fresh air for the marine mammals... housing marine mammals, including pools of water. (c) Lighting. Indoor housing facilities for marine mammals shall have ample lighting, by natural or artificial means, or both, of a quality, distribution...

9 CFR 3.102 - Facilities, indoor.

Code of Federal Regulations, 2010 CFR

2010-01-01

... be ventilated by natural or artificial means to provide a flow of fresh air for the marine mammals... housing marine mammals, including pools of water. (c) Lighting. Indoor housing facilities for marine mammals shall have ample lighting, by natural or artificial means, or both, of a quality, distribution...

Implantation of Louisiana Electric Cone Penetrometer System (LECOPS) for design of transportation facilities : executive summary.

DOT National Transportation Integrated Search

1994-03-01

For several decades, the Louisiana Department of Transportation and Development (LDOTD) has been able to rely on an ample supply of labor with appropriate equipment to provide soil design data. Budget cutbacks have forced reduction in personnel and e...

14 CFR 23.1563 - Airspeed placards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... multiengine-powered airplanes of more than 6,000 pounds maximum weight, and turbine engine-powered airplanes, the maximum value of the minimum control speed, VMC (one-engine-inoperative) determined under § 23.149... control and the airspeed indicator has features such as low speed awareness that provide ample warning...

14 CFR 23.1563 - Airspeed placards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... multiengine-powered airplanes of more than 6,000 pounds maximum weight, and turbine engine-powered airplanes, the maximum value of the minimum control speed, VMC (one-engine-inoperative) determined under § 23.149... control and the airspeed indicator has features such as low speed awareness that provide ample warning...

The Implications of Christian Anti-Semitism for Educators.

ERIC Educational Resources Information Center

O'Reilly, Patricia

1995-01-01

Maintains that the history of anti-Semitism has historical links to Christian theology. Asserts that Christianity provided ample fuel for the secular anti-Semitism preached by Hitler and the Nazi party. Contends that educators can draw important lessons on the value of education and the pedagogy of teaching history. (CFR)

INTERIOR VIEW OF TANK CHARGING ROOM ON LEVEL 4; NOTE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW OF TANK CHARGING ROOM ON LEVEL 4; NOTE HERRINGBONE-PATTERNED BRICK FLOOR; TIMBER SUBSTRUCTURE CARRIED CRANE USED TO REMOVE HEAVY TANK COVERS; WINDOWS IN ROOFTOP MONITOR PROVIDED AMPLE NATURAL LIGHT - Rath Packing Company, Inedible Tank House, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Tudor and Stuart Drama. Goldentree Bibliographies.

ERIC Educational Resources Information Center

Ribner, Irving, Comp.

This selective bibliography, a guide to scholarship in Tudor and Stuart drama, attempts to provide ample coverage of the major topics and authors, with emphasis on work published since 1920. References excluded are most non-English studies, studies devoted exclusively to anonymous plays or those of minor authors, and unpublished dissertations.…

Choice-Driven Peer Play, Self-Regulation and Number Sense

ERIC Educational Resources Information Center

Ivrendi, Asiye

2016-01-01

Peer play provides ample opportunities for the use and development of self-regulatory and mathematical skills. This study aimed at examining whether children's engagement in solitary low-level play, interactive play and competent play influences their self-regulatory and number sense skills. The effect of demographic variables and children's…

Reciprocity and Social Capital in Sibling Relationships of People with Disabilities

ERIC Educational Resources Information Center

Kramer, John; Hall, Allison; Heller, Tamar

2013-01-01

Sibling relationships are some of the longest-lasting relationships people experience, providing ample opportunities to build connections across the life span. For siblings and people with intellectual and developmental disabilities (IDD), these connections take on an increased significance as their families age and parents can no longer provide…

Structuring Opportunity after Entry: Who Has Access to High Quality Instruction during College?

ERIC Educational Resources Information Center

Roksa, Josipa

2016-01-01

Background/Context: When inequality of opportunity is discussed in higher education, it typically pertains to access to college. Ample research has examined sociodemographic inequalities in transition to higher education and enrollment in particular types of institutions. Although providing valuable insights, social stratification research does…

Taming the Wild: Approaches to Nature in Japanese Early Childhood Education

ERIC Educational Resources Information Center

Burke, Rachael S.

2014-01-01

The Japanese early childhood curriculum provides ample opportunities for children to interact with nature and to learn about natural phenomena. However, using Kalland (1995) and Martinez's (2008) theories about Japanese constructions of nature, this paper argues that most Japanese early childhood experiences do not constitute direct contact with…

A Review of Psychotherapy Outcome Research: Considerations for School-Based Mental Health Providers

ERIC Educational Resources Information Center

Zirkelback, Emily A.; Reese, Robert J.

2010-01-01

Evaluating psychotherapeutic outcome is an important endeavor given psychology's focus on identifying effective treatments. There is ample evidence to suggest that psychotherapy interventions for children and adolescents are effective. Unfortunately, the child and adolescent psychotherapy outcome literature lags behind the adult-focused outcome…

A General Purpose Experiment Controller for low cost Space Application

NASA Astrophysics Data System (ADS)

Guzman-Garcia, D.; Rowland, D. E.; Uribe, P.; Nieves-Chinchilla, T.

2012-12-01

Space activities are very expensive and include a high degree of risk. Nowadays, CubeSat missions represent a fast and inexpensive way to conduct scientific space research. These platforms are less expensive to develop and build than conventional satellites. There are ample demonstration that these platforms are well suited for a wide range of science missions in different fields, such as astrobiology, astronomy, atmospheric science, space weather and biology. This paper presents a hybrid "processor in an Field Programmable Gate Array (FPGA)" experiment/spacecraft controller for Cubesat missions. The system has two objectives, first is to obtain a multipurpose and easily customizable system aimed at processing the data from the widest kind of instruments and second, to provide the system with the highest processing capabilities in order to be able to perform complex onboard algorithms. Due to the versatility of the system and its reduced dimensions, it can be employed in different space platforms. The system is envisioned to be employed for the first time as the smart radio receiver for the upcoming NASA FireStation instrument. It is one of four experiments manifested to fly on an experiment pallet the U.S Department of Defense plans to deploy on the International Space Station in 2013. FireStation will continue analyzing the link between the Lightning and the Terrestrial Gamma Rays initiated by the FireFly Cubesat. The system is responsible for the management of a set of small Heliophysics instrumentats, including a photometer, magnetometer, and electric and magnetic field antennas. A description of the system architecture and its main features are presented. The main functional and performance tests during the integration and calibration phase of the instruments are also discussed.

HAARP 2011 Summer Student Research Campaign

DTIC Science & Technology

2012-10-16

in order to take advantage of a wide variety of background ionospheric conditions and to provide ample time for each student to investigate...The SSRC expands on the PARS Summer School by providing a significant increase in facility operational time. This has advantages in several areas...in several advantages for scheduling and conducting experiments: (1) Higher ionospheric density yields higher F-region critical frequency (foF2

[An assessment of fiscal space for public health in Peru].

PubMed

Matus-López, Mauricio; Toledo, Lorena Prieto; Pedraza, Camilo Cid

2016-08-01

Objective To assess the fiscal space for public health in Peru so as to attain the goal of raising health spending to 6% of gross domestic product, as agreed upon by member countries of the Pan American Health Organization in 2014. Methods The main sources of fiscal space were identified by means of a thorough literature review. Technical feasibility was determined from statistics and national and international surveys and by reviewing various documents and official reports. Political feasibility was ascertained by studying policy guidelines. Results The sources showing the greatest technical and political feasibility are economic growth, a broadening of the personal income tax base, and an increase in tobacco-specific taxes. Decreasing informality in the job market and increasing contributory coverage are considered to be less politically feasible, but there is ample technical space for these measures. Conclusions There is enough fiscal space to allow for an increase in public health spending. Nevertheless, the 6% target will be reached only if the timeline is extended, tax revenues are increased, and informality in the job market is reduced.

Challenging pseudoscientific and paranormal beliefs held by some pre-service primary teachers

NASA Astrophysics Data System (ADS)

Happs, John C.

1991-12-01

The widespread public acceptance of many paranormal and pseudoscientific claims should be of some concern to science educators who are striving to produce a scientifically literate community. There is ample evidence to show that students at all levels of our education system believe in aspects of pseudoscience based on claims and assumptions that are in conflict with accumulated scientific knowledge and a rigorous methodology. A survey was designed to assess primary and secondary science teacher-trainees' views. Afterwards 60 students were introduced to the notion of a ‘fair test’ and what constitutes ‘evidence’. Demonstrations of psychic powers were provided and a video shown of professional water-diviners repeatedly failing to locate water under controlled conditions. A re-survey, 3 months later, indicated a rejection of many prior beliefs. However, almost half of the group retained their beliefs in miracles and E.S.P. whilst more than 40% retained their belief in visitors from outer space and that the solar system was created by a supernatural force.

Sporulation: how to survive on planet Earth (and beyond).

PubMed

Huang, Mingwei; Hull, Christina M

2017-10-01

Sporulation is a strategy widely utilized by a wide variety of organisms to adapt to changes in their individual environmental niches and survive in time and/or space until they encounter conditions acceptable for vegetative growth. The spores produced by bacteria have been the subjects of extensive studies, and several systems such as Bacillus subtilis have provided ample opportunities to understand the molecular basis of spore biogenesis and germination. In contrast, the spores of other microbes, such as fungi, are relatively poorly understood. Studies of sporulation in model systems such as Saccharomyces cerevisiae and Aspergillus nidulans have established a basis for investigating eukaryotic spores, but very little is known at the molecular level about how spores function. This is especially true among the spores of human fungal pathogens such as the most common cause of fatal fungal disease, Cryptococcus neoformans. Recent proteomic studies are helping to determine the molecular mechanisms by which pathogenic fungal spores are formed, persist and germinate into actively growing agents of human disease.

Star-Formation Histories of MUSCEL Galaxies

NASA Astrophysics Data System (ADS)

Young, Jason; Kuzio de Naray, Rachel; Xuesong Wang, Sharon

2018-01-01

The MUSCEL program (MUltiwavelength observations of the Structure, Chemistry and Evolution of LSB galaxies) uses combined ground-based/space-based data to determine the spatially resolved star-formation histories of low surface brightness (LSB) galaxies. LSB galaxies are paradoxical in that they are gas rich but have low star-formation rates. Here we present our observations and fitting technique, and the derived histories for select MUSCEL galaxies. It is our aim to use these histories in tandem with velocity fields and metallicity profiles to determine the physical mechanism(s) that give these faint galaxies low star-formation rates despite ample gas supplies.

Atomic Oxygen Durability Evaluation of Protected Polymers Using Thermal Energy Plasma Systems

NASA Technical Reports Server (NTRS)

Banks, Bruce A.; Rutledge, Sharon K.; Degroh, Kim K.; Stidham, Curtis R.; Gebauer, Linda; Lamoreaux, Cynthia M.

1995-01-01

The durability evaluation of protected polymers intended for use in low Earth orbit (LEO) has necessitated the use of large-area, high-fluence, atomic oxygen exposure systems. Two thermal energy atomic oxygen exposure systems which are frequently used for such evaluations are radio frequency (RF) plasma ashers and electron cyclotron resonance plasma sources. Plasma source testing practices such as ample preparation, effective fluence prediction, atomic oxygen flux determination, erosion measurement, operational considerations, and erosion yield measurements are presented. Issues which influence the prediction of in-space durability based on ground laboratory thermal energy plasma system testing are also addressed.

An Investigation of Alignment in CMC from a Sociocognitive Perspective

ERIC Educational Resources Information Center

Uzum, Baburhan

2010-01-01

Computer technology improves the process of SLA by providing access to an ample amount of input within a communicative context in which participants can engage in synchronous and asynchronous conversations (Payne & Whitney, 2002; Sykes, 2005). This research project aims to investigate the role of alignment in learning a second language within the…

Plumbing. Trade and Industrial Education Course of Study.

ERIC Educational Resources Information Center

Erisman, Kenneth E., Comp.; Gerberich, Charles F., Comp.

Intended to be used as a teaching and learning guide, the basic course of study presented in these materials is designed to provide the essentials of the plumbing trade, insuring that students who successfully complete the course will have sufficient competencies for initial employment and ample orientation for growth and development. The course…

Cognitive Tools for Successful Branding

ERIC Educational Resources Information Center

Hernandez, Lorena Perez

2011-01-01

This article aims to fill a gap in current studies on the semantics of branding. Through the analysis of a number of well-known international brand names, we provide ample evidence supporting the claim that a finite set of cognitive operations, such as those of domain reduction and expansion, mitigation, and strengthening, among others, can…

Understanding Student Engagement during Simulations in IB Global Politics

ERIC Educational Resources Information Center

Gleek, Charles

2015-01-01

There is ample discussion in academic and policy circles, as well as amongst the general public, about the ways in which classroom instructors can provide more engaging learning experiences for students. This research examines the ways in which students engage participating in classroom simulations as it pertains to the assigned learning outcomes…

Romantic Knowledge. Research & Occasional Paper Series: CSHE.5.15

ERIC Educational Resources Information Center

Pelfrey, Patricia A.

2015-01-01

While British Romantic literature provides ample evidence of the pleasures of knowledge, it also reveals strong counter-evidence of its power to inflict a sense of intellectual impairment and diminution. This Romantic ambivalence sprang from a complex of ideas and anxieties about the potentially corrosive effects of certain kinds of education and…

Development of a New Fear of Hypoglycemia Scale: FH-15

ERIC Educational Resources Information Center

Anarte Ortiz, Maria Teresa; Caballero, Francisco Felix; Ruiz de Adana, Maria Soledad; Rondan, Rosa Maria; Carreira, Monica; Dominguez-Lopez, Marta; Machado, Alberto; Gonzalo-Marin, Montserrat; Tapia, Maria Jose; Valdes, Sergio; Gonzalez-Romero, Stella; Soriguer, Federico C.

2011-01-01

Hypoglycemia is the most common adverse event associated with insulin treatment in diabetes. The consequences of hypoglycemia can be quite aversive and potentially life threatening. The physical sequelae provide ample reason for patients to fear hypoglycemia and avoid episodes. For these reasons, our purpose in this study was to develop a new…

Effects of Large Impacts on Mars: Implications for River Formation

NASA Technical Reports Server (NTRS)

Segura, T. L.; Toon, O. B.; Colaprete, A.; Zahnle, K.

2002-01-01

The Martian crater record provides ample evidence of the impacts of large (> 100 km) objects. These objects create hot global debris layers meters or more in depth, cause long term warming, and are capable of melting and precipitating a significant amount of water globally. Additional information is contained in the original extended abstract.

Co-Teaching Math Content and Math Pedagogy for Elementary Pre-Service Teachers: A Pilot Study

ERIC Educational Resources Information Center

Ford, Pari; Strawhecker, Jane

2011-01-01

With a national need to improve Science, Technology, Engineering and Mathematics Education (STEM), elementary pre-service teachers must be provided with ample opportunities to increase their own knowledge and confidence in STEM disciplines. This article describes a Math Block experience developed for a special population of non-traditional…

Should Master's Level Training To Provide Rural Services Survive?

ERIC Educational Resources Information Center

Keller, Peter A.

Despite recent efforts to encourage federal funding of psychological services for underserved populations such as the elderly and residents of rural areas, ample evidence suggests that rural areas are underserved by psychologists. Drawing on data from rural and urban areas in Pennsylvania, this paper argues that master's level training can provide…

75 FR 38858 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

... 60-day initial trial period for parties wishing to evaluate the Correlix RaceTeam offering for the..., and experience with, the Correlix RaceTeam product while simultaneously providing ample time for the... just and equitable principles of trade, to foster cooperation and coordination with persons engaged in...

Work Ethics Training: Reflections of Technical College Students

ERIC Educational Resources Information Center

Wilson, Sandy

2017-01-01

Ample research exists on ethics in the workplace and skills college graduates should have to seek and attain long-term gainful employment. The literature has provided some insight into the understanding of ethical behavior as reported by students and employers; however a gap exists in research which documents college student experiences during…

A book review of Spatial data analysis in ecology and agriculture using R

USDA-ARS?s Scientific Manuscript database

Spatial Data Analysis in Ecology and Agriculture Using R is a valuable resource to assist agricultural and ecological researchers with spatial data analyses using the R statistical software(www.r-project.org). Special emphasis is on spatial data sets; how-ever, the text also provides ample guidance ...

Measurement in Instructional Communication Research: A Decade in Review

ERIC Educational Resources Information Center

Mazer, Joseph P.; Graham, Elizabeth E.

2015-01-01

Periodic assessment and scrutiny of the discipline's measurement practices, instruments, and research findings are necessary to provide clarity and direction by revealing what we know, how we know it, and where the knowledge gaps exist. Reflective reviews have produced ample appraisals of the theory, research, and methods employed in the conduct…

A STRUCTURAL COURSE FOR VOCATIONAL ENGLISH.

ERIC Educational Resources Information Center

ERICKSON, JOHN

A COURSE, COMPLETE WITH DETAILED LESSON PLANS AND PRACTICE DRILLS, HAS BEEN DEVELOPED AT SAN DIEGO STATE COLLEGE, TO PROVIDE THE ADULT SPANISH-SPEAKING STUDENT WITH A BASIC FOUNDATION IN AMERICAN-ENGLISH GRAMMATICAL STRUCTURE, AS WELL AS AN AMPLE DAILY AND PROFESSIONAL VOCABULARY. THE IDEA OF TRANSLATING CONCEPTS AND VOCABULARY IS USED TO TEACH…

Juvenile Offender Comprehensive Reentry Substance Abuse Treatment

ERIC Educational Resources Information Center

Watson, Donnie W.

2004-01-01

The literature provides ample evidence of the relationship of substance abuse to crime. Research over the last 20 years has established a strong correlation between substance abuse and juvenile delinquency (held, 1998). Currently, there are more than 350,000 juveniles on probation and in continuing care programs in the U.S. who have substance…

Renewable Energy Education in India

ERIC Educational Resources Information Center

Bajpai, Shrish; Kidwai, Naimur Rahman

2017-01-01

The issue of renewable energy sources that have great potential to give solutions to the longstanding energy problems of India has been considered. It has been stated that renewable energy sources are an important part of India's plan to increase energy security and provide new generation with ample job opportunities. India's plans to move towards…

75 FR 33216 - Payment or Reimbursement for Emergency Treatment Furnished by Non-VA Providers in Non-VA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... treatment of eligible veterans at non-VA facilities and expand the circumstances under which payment for..., potentially eligible veterans would be appropriately afforded ample opportunity to qualify for this expanded...; 64.010, Veterans Nursing Home Care; and 64.011, Veterans Dental Care. Signing Authority The Secretary...

School Lunches in Times of Food Scarcity

ERIC Educational Resources Information Center

Federal Aid Planner, 1973

1973-01-01

Attempts to provide the school administrator and his food service manager with information about how to best operate the cafeteria in view of food shortages and new USDA regulations. Describes foods that will be in relatively ample supply during coming months and analyzes whether food vending machines are a help or a menace to nutritious lunch…

Two-dimensional liquid chromatography (LC) of phenolic compounds from the shoots of Rubus idaeus 'Glen Ample' cultivar variety.

PubMed

Kula, Marta; Głód, Daniel; Krauze-Baranowska, Mirosława

2016-03-20

In this study the application of two-dimensional LC (2D LC) for qualitative analysis of polyphenols and simple phenols in the shoots of Rubus idaeus 'Glen Ample' variety is presented. In the preliminary analysis, the methanol extract of the shoots was analyzed by one-dimensional LC. One-dimensional LC separation profiles of phenolics from R. idaeus 'Glen Ample' shoots were dependent on column type, mobile phase composition and gradient program used. Two-dimensional LC system was built from connecting an octadecyl C-18 silica column in the first dimension and pentafluorophenyl column in the second dimension, coupled with DAD and MS (ESI, APCI, DUIS ionization) detectors. A total of 34 phenolic compounds belonging to the groups of phenolic acids, ellagitannins, flavan-3-ols, flavonols and ellagic acid conjugates were identified in the shoots of R. idaeus 'Glen Ample'. The established 2D LC method offers an effective tool for analysis of phenolics present in Rubus species. Copyright © 2015 Elsevier B.V. All rights reserved.

Measuring gravitational effects on antimatter in space

NASA Astrophysics Data System (ADS)

Piacentino, Giovanni Maria; Gioiosa, Antonio; Palladino, Anthony; Venanzoni, Graziano

2017-04-01

A direct measurement of the gravitational acceleration of antimatter has never been performed to date. Recently, such an experiment has been proposed, using antihydrogen with an atom interferometer and an antihydrogen confinament has been realized at CERN. In alternative we propose an experimental test of the gravitational interaction with antimatter by measuring the branching fraction of the CP violating decay of KL in space. In fact, even if the theoretical Standard Model explains the CPV with the presence of pure phase in the KMC Kobaiashi-Maskava-Cabibbo matrix, ample room is left for contributions by other interactions and forces to generate CPV in the mixing of the neutral K and B mesons. Gravitation is a good candidate and we show that at the altitude of the International Space Station, gravitational effects may change the level of CP violation such that a 5 sigma discrimination may be obtained by collecting the KL produced by the cosmic proton flux within a few years.

Urban Green Space Dynamics and Distributional Equity in Kumasi, Ghana

NASA Astrophysics Data System (ADS)

Nero, Bertrand

2016-08-01

Urban green spaces (UGS) are crucial for urban sustainability and resilience to environmental vulnerabilities but are often marginalized in cities in the global south. This paper analyzed the spatio-temporal change, extent and distributional inequities associated with UGS in Kumasi, Ghana. Spatial techniques and Gini index were deployed in the assessments.Kumasi UGS cover is currently 33 % but is declining fourfold faster in recent years (2009-2014) than previously (1986-2002). Shannon entropy for built-up sprawl and mean per capita UGS area in 2014 were 0.99 and 25 m2, respectively. Per capita UGS area for 2009 (r2 = 0.50, p=0.049) and 2014 (r2 = 0.53, p=0.0398) were moderately correlated with socioeconomic conditions of submetropolis. The Gini coefficient for both vegetation and tree cover was 0.26.Green space cover in Kumasi is plummeting and somewhat unevenly distributed. Strategic planning for UGS can ensure ample availability, equity in access, and resilience to climate related vulnerabilities.

The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line.

PubMed

Wang, Fang; Qiao, Linan; Chen, Liwei; Zhang, Cong; Wang, Yan; Wang, Yinsong; Liu, Yuanyuan; Zhang, Ning

2016-05-01

In this study, acidic and alkaline pullulan derivates were synthesized and their immunomodulatory activities compared to pullulan were investigated in human pDC-like CAL-1 cell line. Pullulan was reacted respectively with succinic anhydride and N-(-2-aminoethyl)-1,3-propanediamine/N,N-carbonyl diimidazole to form acidic pullulan monosuccinate (SUPL) and alkaline pullulan-g-N-(-2-aminoethyl)-1,3-propanediamine (AMPL). In CAL-1 cells, pullulan, SUPL and AMPL up-regulated the mRNA expressions of type I interferons (IFN), including IFN-α and IFN-β1, and some other proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-23 (IL-23), and also significantly enhanced the protein expressions of IFN-α and TNF-α. The activation of nuclear factor kappa B (NF-κB) and the nuclear translocations of interferon regulation factors (IRFs), including IRF-3 and IRF-5, exhibited pivotal roles in the immune responses induced by pullulan, SUPL and AMPL. By comparison, pullulan and SUPL displayed weak effects on the activation of CAL-1 cells, but AMPL showed remarkably enhanced immunomodulatory activities, which were comparable to that induced by R848, an agonist for Toll-like receptor (TLR) 7/8. Our results suggested that AMPL, as an alkaline pullulan derivative, could be used as a potent immunomodulatory agent in the food and pharmacological fields. Copyright © 2016 Elsevier B.V. All rights reserved.

Propulsion Technologies for Future Commercial Aircraft

NASA Technical Reports Server (NTRS)

Follen, Gregory J.

2013-01-01

Mr. Follen has been invited talk on subject of Greening of Aerospace and Aviation Canada-Ohio Aerospace Summit 2013, February 25-26, 2013. This two-day, bi-national aerospace and aviation conference will focus on identifying business and research opportunities providing meaningful industry updates with ample opportunity to network and scheduled business-to-business and researcher-to-researcher meetings.

24 CFR 266.638 - Issuance of HFA Debenture.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Debenture shall have a term of five years in order to afford the mortgagor ample time to cure the default or the HFA time to foreclose and/or resell the project. HUD may provide a written extension of the five... annually on the anniversary date of the initial claim payment. Interest is due on the full face amount of...

The Effects of Group Coaching on the Homework Problems Experienced by Secondary Students with and without Disabilities

ERIC Educational Resources Information Center

Merriman, Donald; Codding, Robin S.; Tryon, Georgiana Shick; Minami, Takuya

2016-01-01

Research on the effectiveness of homework provides ample evidence that homework has a positive effect on learning, particularly for secondary students. Unfortunately, the rate of consistent homework completion for students, with and without disabilities, is low. This study used a between-groups design to examine the differential effectiveness of…

A Conversation Analysis of the Function of Silence in Writing Conferences

ERIC Educational Resources Information Center

Mirzaee, Milad; Yaqubi, Baqer

2016-01-01

One of the recent issues in English as a Second/Foreign Language (ESL/EFL) writing instruction has been the quest for a more effective way to give feedback to L2 learners' writing drafts. Although teacher-learner writing conferences have been increasingly used for providing ample opportunity for negotiating revisions, relatively little attention…

Turf and Lawn Management: A Course in Agricultural Education. Curriculum Guide. Preliminary Draft.

ERIC Educational Resources Information Center

Mercer, R. J., Ed.

The curriculum guide (preliminary draft) is a result of the revision of the total South Carolina agricultural education curriculum; the scope of the turf and lawn management industry and its direct and indirect employment opportunities provide ample reasons for such a course offering in South Carolina high schools. The guide presents objectives,…

Ensuring that forests are adapted to future climates

Treesearch

Brad St. Clair; Glenn Howe

2010-01-01

Successful reforestation requires that planted or naturally regenerated seedlings are well suited to a site. Genetic studies of forest trees provide ample evidence of large differences among seed sources in adaptive traits--traits such as the timing of growth initiation and cessation, cold and drought hardiness, and growth rates. Much of this variation is related to...

The Onion Model: Myth or Reality in the Field of Individual Differences Psychology?

ERIC Educational Resources Information Center

Cools, Eva; Bellens, Kim

2012-01-01

To bring order in concepts related to individual learner differences, Curry (1983) designed the three-layered onion model. As this model provides an interesting way to distinguish related concepts--such as cognitive styles and approaches to studying--on the basis of their stability in learning situations, ample studies build further on this model.…

The Impact of Gender on Attainment in Learning English as a Foreign Language

ERIC Educational Resources Information Center

Glówka, Danuta

2014-01-01

This study examined the impact of gender on students' achievement in learning English as a foreign language in secondary and higher vocational schools in Poland, as well as teachers' and students' opinions concerning the importance of this influence. The collected data provided ample evidence that girls achieved significantly better results than…

STEM-focused High Schools as a Strategy for Enhancing Readiness for Postsecondary STEM Programs

ERIC Educational Resources Information Center

Means, Barbara; Wang, Haiwen; Young, Viki; Peters, Vanessa L.; Lynch, Sharon J.

2016-01-01

The logic underlying inclusive STEM high schools (ISHSs) posits that requiring all students to take advanced college preparatory STEM courses while providing student-centered, reform-oriented instruction, ample student supports, and real-world STEM experiences and role models will prepare and inspire students admitted on the basis of STEM interest…

A Review of Challenges in Developing a National Program for Gifted Children in India's Diverse Context

ERIC Educational Resources Information Center

Kurup, Anitha; Maithreyi, R.

2012-01-01

Large-scale sequential research developments for identification and measurement of giftedness have received ample attention in the West, whereas India's response to this has largely been lukewarm. The wide variation in parents' abilities to provide enriched environments to nurture their children's potential makes it imperative for India to develop…

Small Is Too Big: Achieving a Critical Anti-Mass in the High School.

ERIC Educational Resources Information Center

Gregory, Tom

Developing more effective conceptions of the high school may require radically reducing its size. In today's big high schools, size ensures that control of students is a primary concern and prevents the development of a collegial atmosphere among teachers. Although research provides ample evidence of the superior social climates of small informal…

The Morphology and Syntax of Ergativity: A Typological Approach

ERIC Educational Resources Information Center

Rill, Justin

2017-01-01

This dissertation seeks to answer three loosely-related questions regarding ergativity. First, what is the nature of the morphological phenomena known as ERG=GEN and ERG=POSS? After providing a thorough description with ample data from a wide range of sources, a typological survey of 40 ergative languages concludes that together, they are a fairly…

Beyond La Nina, La Pinta, and La Santa Maria: The Invention and Mental Mapping of the New World

ERIC Educational Resources Information Center

Fernandez, Luis Martinez

2013-01-01

The topics of Columbus's voyages of exploration, the first encounters between Amerindians and Europeans, and the ensuing collision of their respective worlds provide ample opportunities for creative and stimulating pedagogical approaches that go beyond the stale memorization of dates, places, and names. This essay and accompanying classroom…

Silicon quantum processor with robust long-distance qubit couplings.

PubMed

Tosi, Guilherme; Mohiyaddin, Fahd A; Schmitt, Vivien; Tenberg, Stefanie; Rahman, Rajib; Klimeck, Gerhard; Morello, Andrea

2017-09-06

Practical quantum computers require a large network of highly coherent qubits, interconnected in a design robust against errors. Donor spins in silicon provide state-of-the-art coherence and quantum gate fidelities, in a platform adapted from industrial semiconductor processing. Here we present a scalable design for a silicon quantum processor that does not require precise donor placement and leaves ample space for the routing of interconnects and readout devices. We introduce the flip-flop qubit, a combination of the electron-nuclear spin states of a phosphorus donor that can be controlled by microwave electric fields. Two-qubit gates exploit a second-order electric dipole-dipole interaction, allowing selective coupling beyond the nearest-neighbor, at separations of hundreds of nanometers, while microwave resonators can extend the entanglement to macroscopic distances. We predict gate fidelities within fault-tolerance thresholds using realistic noise models. This design provides a realizable blueprint for scalable spin-based quantum computers in silicon.Quantum computers will require a large network of coherent qubits, connected in a noise-resilient way. Tosi et al. present a design for a quantum processor based on electron-nuclear spins in silicon, with electrical control and coupling schemes that simplify qubit fabrication and operation.

Systems analysis of thrombus formation

PubMed Central

Diamond, Scott L.

2016-01-01

The systems analysis of thrombosis seeks to quantitatively predict blood function in a given vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a Blood Systems Biology approach should provide metrics for rate and molecular mechanisms of clot growth, thrombotic risk, pharmacological response, and utility of new therapeutic targets. As a rapidly created multicellular aggregate with a polymerized fibrin matrix, blood clots result from hundreds of unique reactions within and around platelets propagating in space and time under hemodynamic conditions. Coronary artery thrombosis is dominated by atherosclerotic plaque rupture, complex pulsatile flows through stenotic regions producing high wall shear stresses, and plaque-derived tissue factor driving thrombin production. In contrast, venous thrombosis is dominated by stasis or depressed flows, endothelial inflammation, white blood cell-derived tissue factor, and ample red blood cell incorporation. By imaging vessels, patient-specific assessment using computational fluid dynamics provides an estimate of local hemodynamics and fractional flow reserve. High dimensional ex vivo phenotyping of platelet and coagulation can now power multiscale computer simulations at the subcellular to cellular to whole vessel scale of heart attacks or strokes. Additionally, an integrated systems biology approach can rank safety and efficacy metrics of various pharmacological interventions or clinical trial designs. PMID:27126646

Miniature Fuel Processors for Portable Fuel Cell Power Supplies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holladay, Jamie D.; Jones, Evan O.; Palo, Daniel R.

2003-06-02

Miniature and micro-scale fuel processors are discussed. The enabling technologies for these devices are the novel catalysts and the micro-technology-based designs. The novel catalyst allows for methanol reforming at high gas hourly space velocities of 50,000 hr-1 or higher, while maintaining a carbon monoxide levels at 1% or less. The micro-technology-based designs enable the devices to be extremely compact and lightweight. The miniature fuel processors can nominally provide between 25-50 watts equivalent of hydrogen which is ample for soldier or personal portable power supplies. The integrated processors have a volume less than 50 cm3, a mass less than 150 grams,more » and thermal efficiencies of up to 83%. With reasonable assumptions on fuel cell efficiencies, anode gas and water management, parasitic power loss, etc., the energy density was estimated at 1700 Whr/kg. The miniature processors have been demonstrated with a carbon monoxide clean-up method and a fuel cell stack. The micro-scale fuel processors have been designed to provide up to 0.3 watt equivalent of power with efficiencies over 20%. They have a volume of less than 0.25 cm3 and a mass of less than 1 gram.« less

CeSiCò - a new technology for lightweight and cost effective space instruments structures and mirrors

NASA Astrophysics Data System (ADS)

Devilliers, Christophe; Krödel, Matthias

2017-11-01

Alcatel Alenia Space and ECM have jointly developed a new ceramic material to produce lightweight, stiff, stable and cost effective structures and mirrors for space instrument the CesicÒ. Its intrinsic properties, added to ample manufacturing capabilities allow to manufacture stiff and lightweight cost effective mirrors and structure for space instruments. Different scale 1 flight representative CesicÒ optical structures have been manufactured and successfully tested under very strong dynamic environment and cryogenic condition down to 30K CesicÒ is also envisaged for large and lightweight space telescopes mirrors, a large CesicÒ 1 meter class mirror with an area mass of less than 25 Kg/m2 has been sized again launch loads and WFE performance and manufactured. CesicÒ applicability for large focal plane have been demonstrated through different scale 1 breadboards. Based on these successful results, AlcatelAleniaSpace and ECM are now in position to propose for space this technology with new innovative concepts thanks to the CesicÒ manufacturing capabilities. CesicÒ has therefore been selected for the structure and mirrors parts of a flight instrument payload and the manufacturing of the flight hardware is already underway. An high temperature high gain lightweight antenna breadboard is also under manufacturing for Bepi colombo mission. CesicÒ is therefore a good candidate for future challenging space instruments and is currently proposed for Japan and US space projects.

77 FR 4973 - Endangered and Threatened Wildlife and Plants; 90-Day Finding on a Petition to List the San...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... arboreal lichens and vegetation (Hall 1991, p. 616, Pyare and Longland 2001, p. 684; Smith 2007, p. 869...'s habitat seems to be related to conditions that are optimal for nesting and provide an ample supply... nonclimate conditions (e.g., habitat fragmentation). We use our expert judgment to weigh relevant information...

Effect of Alternative and Augmentative Communication on Language and Social Behavior of Children with Autism

ERIC Educational Resources Information Center

Lal, Rubina

2010-01-01

Teaching children with autism is a challenging task for educators and parents, as the children display marked deficits in language and social behaviors. One of the major goals of an intervention program for children with autism is to provide them a method of functional communication and ample opportunities to practice these skills. For some…

A Comparison of Product Realization Frameworks

DTIC Science & Technology

1993-10-01

software (integrated FrameMaker ). Also included are BOLD for on-line documentation delivery, printer/plotter support, and 18 network licensing support. AMPLE...are built with DSS. Documentation tools include an on-line information system (BOLD), text editing (Notepad), word processing (integrated FrameMaker ...within an application. FrameMaker is fully integrated with the Falcon Framework to provide consistent documentation capabilities within engineering

Interactional Processes of Handling Errors in Vocational School: Students Attending to Changes in Vocational Practices

ERIC Educational Resources Information Center

Jonasson, Charlotte

2015-01-01

Making errors is an inevitable part of work and learning situations. Recent research has shown that errors can provide important learning opportunities, in particular in education or training, where there may be ample time and support to learn from them. Yet, more knowledge is needed of how learning from errors is developed through interactional…

Successful Heliophysical Programs Emphasizing the Relation of Earth and the Sun

NASA Astrophysics Data System (ADS)

Morris, P. A.; Reiff, P.; Sumners, C.; McKay, G. A.

2007-05-01

Heliophysical is defined as the interconnectedness of the entire solar-heliospheric-planetary system. Our goals are to introduce easily accessible programs that introduce the Sun and other solar system processes to the public. The programs emphasize the impact of these processes on Earth and its inhabitants over geological time. These types of programs are important as these topics as generally taught as a secondary concept rather than an integrated approach. Space Weather is an excellent mechanism for integrating Earth and space science. Heliophysics, which includes Space Weather, is traditionally part of space science studies, but most students do not understand the effect of the Sun's atmosphere on Earth or the intense effects energetic particles can have on humans, whether traveling through space or exploring the surfaces of the Moon or Mars. Effects are not only limited to space travel and other planetary surfaces but also include effects on Earth's magnetosphere which, in turn, affect radio transmission, GPS accuracy, and on occasion spacecraft loss and terrestrial power outages. Meteoritic impacts are another topic. Impacts on planetary bodies without strong plate tectonic activities provide ample evidence of their occurrence over geological time. As an analog, impacts have also had an extensive record on Earth, but plate tectonics have been responsible for obliterating most of the evidence. We have developed effective and engaging venues for teaching heliophysics, via the internet, CD-Rom's, museum kiosks, and planetarium shows. We have organized workshops for teachers; "NASA Days" and "Sally Ride Festivals" for students, and "Sun-Earth Day" events for the public. Our goals are both to increase k-16 and public literacy on heliophysical processes and to inspire the next generation to enhance the workforce. We will be offering examples of these programs, as well as distributing CD's and DVD's of some of the creative works.

Stable-isotope and solute-chemistry approaches to flow characterization in a forested tropical watershed, Luquillo Mountains, Puerto Rico

Treesearch

Martha A. Scholl; James B. Shanley; Sheila F. Murphy; Jane K. Willenbring; Grizelle Gonzalez

2015-01-01

The prospect of changing climate has led to uncertainty about the resilience of forested mountain watersheds in the tropics. In watersheds where frequent, high rainfall provides ample runoff, we often lack understanding of how the system will respond under conditions of decreased rainfall or drought. Factors that govern water supply, such as recharge rates and...

Source Physics Experiment: Research in Support of Verification and Nonproliferation

DTIC Science & Technology

2011-09-01

designed to provide a carefully controlled seismic and strong motion data set from buried explosions at the Nevada National Security Site (NNSS). The...deposition partitioned into internal (heat and plastic strain) and kinetic (e.g., radiated seismic ) energy, giving more confidence in predicted free...ample information to study dry and water-saturated fractures, local lithology and topography on the radiated seismic wavefield. Spallation on

JPRS Report, Science & Technology, China.

DTIC Science & Technology

1992-12-08

impor- tance of the computer information industry to the develop- ment of the national economy and the people’s standard of living. Forecasts call...past several years, and the application of computers has permeated every trade and industry , providing powerful SCIENCE & TECHNOLOGY POLICY JPRS...system and ample human talent; market potential is large; and it has potential for low cost develop- ment. However, the scale of its industrial

Addressing Structural Barriers to HIV Care among Triply Diagnosed Adults: Project Bridge Oakland.

PubMed

Powers, Christina; Comfort, Megan; Lopez, Andrea M; Kral, Alex H; Murdoch, Owen; Lorvick, Jennifer

2017-05-01

People who are "triply diagnosed" with HIV, mental health issues, and substance-related disorders face tremendous barriers connecting to and remaining in HIV care. Authors of this article implemented Project Bridge Oakland (PBO), an intervention based on harm reduction and trauma-informed care, to help maintain continuity of care for triply diagnosed adults through cycles of criminal justice involvement. From August 2011 to December 2014, a clinical social worker and an HIV physician provided intensive case management for 19 clients living in Oakland, California. By working with clients across a multitude of community, clinic, and correctional spaces while maintaining a low threshold for services, the social worker was able to engage a severely marginalized population in HIV care. This article details the PBO strategies for assisting with a wide range of services needed for community stabilization, navigating criminal justice involvement, and establishing a therapeutic relationship through mundane practices such as eating and waiting for appointments. This article illustrates how programs aimed at stabilizing triply diagnosed clients in the community and connecting them to HIV care require coordination among providers, outreach to engage clients, ample time to work with them, and flexibility to account for the complexities of their day-to-day lives and experiences. © 2017 National Association of Social Workers.

Through the Lens of Operational Art: 1971 Bangladesh Campaign

DTIC Science & Technology

2012-05-17

rather than a formulaic process , allowing ample scope for creativity in its application. The next three sections build the narrative of the...campaign; framing the problem to provide a background to the conflict, outlining the decision-making and the planning process incorporating both the... process itself, as the official history of the campaign by the Indian authorities has not been made public, and the written orders and instructions issued

CH-47C Vulnerability Reduction Modification Program - Fly-by-Wire Backup Demonstration

DTIC Science & Technology

1976-08-01

Actuator Position for Combined Axis Input ............................. 91 4 Systems Assessment Summary................... 95 C-1 Instrumentation Parameters ...SERVO CARD jEETO FROM MIXERS SUfEV __________ HYLIC AMPL AMPLVLE SHUT-O- DOWN DC PWR LOGIC REA MIONITOR SUMMER *O:EO SWITCH- BUFFER OVER 1 NETWORK...and ranels (Figures 12 and 13). The existing DELS preflight test set, which provides access to the system parameters , was installed along with the

Synthetic torpor: A method for safely and practically transporting experimental animals aboard spaceflight missions to deep space.

PubMed

Griko, Yuri; Regan, Matthew D

2018-02-01

Animal research aboard the Space Shuttle and International Space Station has provided vital information on the physiological, cellular, and molecular effects of spaceflight. The relevance of this information to human spaceflight is enhanced when it is coupled with information gleaned from human-based research. As NASA and other space agencies initiate plans for human exploration missions beyond low Earth orbit (LEO), incorporating animal research into these missions is vitally important to understanding the biological impacts of deep space. However, new technologies will be required to integrate experimental animals into spacecraft design and transport them beyond LEO in a safe and practical way. In this communication, we propose the use of metabolic control technologies to reversibly depress the metabolic rates of experimental animals while in transit aboard the spacecraft. Compared to holding experimental animals in active metabolic states, the advantages of artificially inducing regulated, depressed metabolic states (called synthetic torpor) include significantly reduced mass, volume, and power requirements within the spacecraft owing to reduced life support requirements, and mitigated radiation- and microgravity-induced negative health effects on the animals owing to intrinsic physiological properties of torpor. In addition to directly benefitting animal research, synthetic torpor-inducing systems will also serve as test beds for systems that may eventually hold human crewmembers in similar metabolic states on long-duration missions. The technologies for inducing synthetic torpor, which we discuss, are at relatively early stages of development, but there is ample evidence to show that this is a viable idea and one with very real benefits to spaceflight programs. The increasingly ambitious goals of world's many spaceflight programs will be most quickly and safely achieved with the help of animal research systems transported beyond LEO; synthetic torpor may enable this to be done as practically and inexpensively as possible. Published by Elsevier Ltd.

Synthetic torpor: A method for safely and practically transporting experimental animals aboard spaceflight missions to deep space

NASA Astrophysics Data System (ADS)

Griko, Yuri; Regan, Matthew D.

2018-02-01

Animal research aboard the Space Shuttle and International Space Station has provided vital information on the physiological, cellular, and molecular effects of spaceflight. The relevance of this information to human spaceflight is enhanced when it is coupled with information gleaned from human-based research. As NASA and other space agencies initiate plans for human exploration missions beyond low Earth orbit (LEO), incorporating animal research into these missions is vitally important to understanding the biological impacts of deep space. However, new technologies will be required to integrate experimental animals into spacecraft design and transport them beyond LEO in a safe and practical way. In this communication, we propose the use of metabolic control technologies to reversibly depress the metabolic rates of experimental animals while in transit aboard the spacecraft. Compared to holding experimental animals in active metabolic states, the advantages of artificially inducing regulated, depressed metabolic states (called synthetic torpor) include significantly reduced mass, volume, and power requirements within the spacecraft owing to reduced life support requirements, and mitigated radiation- and microgravity-induced negative health effects on the animals owing to intrinsic physiological properties of torpor. In addition to directly benefitting animal research, synthetic torpor-inducing systems will also serve as test beds for systems that may eventually hold human crewmembers in similar metabolic states on long-duration missions. The technologies for inducing synthetic torpor, which we discuss, are at relatively early stages of development, but there is ample evidence to show that this is a viable idea and one with very real benefits to spaceflight programs. The increasingly ambitious goals of world's many spaceflight programs will be most quickly and safely achieved with the help of animal research systems transported beyond LEO; synthetic torpor may enable this to be done as practically and inexpensively as possible.

Optical Air Flow Measurements in Flight

NASA Technical Reports Server (NTRS)

Bogue, Rodney K.; Jentink, Henk W.

2004-01-01

This document has been written to assist the flight-test engineer and researcher in using optical flow measurements in flight applications. The emphasis is on describing tradeoffs in system design to provide desired measurement performance as currently understood. Optical system components are discussed with examples that illustrate the issues. The document concludes with descriptions of optical measurement systems designed for a variety of applications including aeronautics research, airspeed measurement, and turbulence hazard detection. Theoretical discussion is minimized, but numerous references are provided to supply ample opportunity for the reader to understand the theoretical underpinning of optical concepts.

On token reinforcement and stuttering therapy: another view on findings reported by Howie and Woods (1982).

PubMed

Ingham, R J

1983-01-01

Howie and Woods (1982) have provided data that, they claim, indicate that a token reinforcement system is redundant in instating and shaping fluent speech within a stuttering treatment program developed by Ingham and Andrews (1973a, b). However, there were substantial procedural differences between the treatment programs referred to in both studies, as well as methodological weaknesses in Howie and Woods' study. These factors provide ample sources of explanation for Howie and Woods' failure to demonstrate benefits from their token reinforcement system.

PIXE-electrophoresis shows starving collembolan reallocates protein-bound metals.

PubMed

Bengtsson, Göran; Pallon, Jan; Nilsson, Christina; Triebskorn, Rita; Köhler, Heinz-R

2016-01-01

One of multiple functions of metalloproteins is to provide detoxification to excess metal levels in organisms. Here we address the induction and persistence of a range of low to high molecular weight copper- and zinc binding proteins in the collembolan species Tetrodontophora bielanensis exposed to copper- and zinc-enriched food, followed by a period of recovery from metal exposure, in absence and presence of food. After 10 days of feeding copper and zinc contaminated yeast, specimens were either moved to ample of leaf litter material from their woodland stand of origin or starved (no food offered). The molecular weight distribution of metal binding proteins was determined by native polyacryl gel electrophoresis. One gel was stained with Comassie brilliant blue and a duplicate gel dried and scanned for the amount of copper and zinc by particle-induced X-ray emission. Specimens exposed to copper and recovered from it with ample of food had copper bound to two groups of rather low molecular weight proteins (40-50 kDa) and two of intermediate size (70-80 kDa). Most zinc in specimens from the woodland stand was bound to two large proteins of about 104 and 106 kDa. The same proteins were holding some zinc in metal-exposed specimens, but most zinc was found in proteins <40 kDa in size. Specimens recovered from metal exposure in presence of ample of food had the same distribution pattern of zinc binding proteins, whereas starved specimens had zinc as well as copper mainly bound to two proteins of 8 and 10 kDa in size. Thus, the induction and distribution of copper- and zinc-binding proteins depend on exposure conditions, and the presence of low molecular weight binding proteins, characteristic of metallothioneins, was mainly limited to starving conditions.

Recent results from Daya Bay

NASA Astrophysics Data System (ADS)

Chua, Ming-chung

2016-11-01

Utilizing powerful nuclear reactors as antineutrino sources, high mountains to provide ample shielding from cosmic rays in the vicinity, and functionally identical detectors with large target volume for near-far relative measurement, the Daya Bay Reactor Neutrino Experiment has achieved unprecedented precision in measuring the neutrino mixing angle θ13 and the neutrino mass squared difference |Δm2ee|. I will report the latest Daya Bay results on neutrino oscillations and light sterile neutrino search.

Digital PIV Measurements in the Diffuser of a High Speed Centrifugal Compressor

NASA Technical Reports Server (NTRS)

Wernet, Mark P.

1998-01-01

Particle Imaging Velocimetry (PIV) is a powerful measurement technique which can be used as an alternative or complementary approach to Laser Doppler Velocimetry (LDV) in a wide range of research applications. PIV data are measured simultaneously at multiple points in space, which enables the investigation of the non-stationary spatial structures typically encountered in turbomachinery. Obtaining ample optical access, sufficiently high seed particle concentrations and accurate synchronization of image acquisition relative to impeller position are the most formidable tasks in the successful implementation of PIV in turbomachinery. Preliminary results from the successful application of the standard 2-D digital PIV technique in the diffuser of a high speed centrifugal compressor are presented. Instantaneous flow. measurements were also obtained during compressor surge.

Thermal dark matter from a highly decoupled sector

DOE PAGES

Berlin, Asher; Hooper, Dan; Krnjaic, Gordan

2016-11-17

It has recently been shown that if the dark matter is in thermal equilibrium with a sector that is highly decoupled from the Standard Model, it can freeze out with an acceptable relic abundance, even if the dark matter is as heavy as ~1–100 PeV. In such scenarios, both the dark and visible sectors are populated after inflation, but with independent temperatures. The lightest particle in the dark sector will be generically long-lived and can come to dominate the energy density of the Universe. Upon decaying, these particles can significantly reheat the visible sector, diluting the abundance of dark mattermore » and thus allowing for dark matter particles that are much heavier than conventional WIMPs. In this study, we present a systematic and pedagogical treatment of the cosmological history in this class of models, emphasizing the simplest scenarios in which a dark matter candidate annihilates into hidden sector particles which then decay into visible matter through the vector, Higgs, or lepton portals. In each case, we find ample parameter space in which very heavy dark matter particles can provide an acceptable thermal relic abundance. We also discuss possible extensions of models featuring these dynamics.« less

Phosphorous Diffuser Diverged Blue Laser Diode for Indoor Lighting and Communication

PubMed Central

Chi, Yu-Chieh; Hsieh, Dan-Hua; Lin, Chung-Yu; Chen, Hsiang-Yu; Huang, Chia-Yen; He, Jr-Hau; Ooi, Boon; DenBaars, Steven P.; Nakamura, Shuji; Kuo, Hao-Chung; Lin, Gong-Ru

2015-01-01

An advanced light-fidelity (Li-Fi) system based on the blue Gallium nitride (GaN) laser diode (LD) with a compact white-light phosphorous diffuser is demonstrated for fusing the indoor white-lighting and visible light communication (VLC). The phosphorous diffuser adhered blue GaN LD broadens luminescent spectrum and diverges beam spot to provide ample functionality including the completeness of Li-Fi feature and the quality of white-lighting. The phosphorous diffuser diverged white-light spot covers a radiant angle up to 120o with CIE coordinates of (0.34, 0.37). On the other hand, the degradation on throughput frequency response of the blue LD is mainly attributed to the self-feedback caused by the reflection from the phosphor-air interface. It represents the current state-of-the-art performance on carrying 5.2-Gbit/s orthogonal frequency-division multiplexed 16-quadrature-amplitude modulation (16-QAM OFDM) data with a bit error rate (BER) of 3.1 × 10−3 over a 60-cm free-space link. This work aims to explore the plausibility of the phosphorous diffuser diverged blue GaN LD for future hybrid white-lighting and VLC systems. PMID:26687289

Phosphorous Diffuser Diverged Blue Laser Diode for Indoor Lighting and Communication

NASA Astrophysics Data System (ADS)

Chi, Yu-Chieh; Hsieh, Dan-Hua; Lin, Chung-Yu; Chen, Hsiang-Yu; Huang, Chia-Yen; He-Hau, Jr.; Ooi, Boon; Denbaars, Steven P.; Nakamura, Shuji; Kuo, Hao-Chung; Lin, Gong-Ru

2015-12-01

An advanced light-fidelity (Li-Fi) system based on the blue Gallium nitride (GaN) laser diode (LD) with a compact white-light phosphorous diffuser is demonstrated for fusing the indoor white-lighting and visible light communication (VLC). The phosphorous diffuser adhered blue GaN LD broadens luminescent spectrum and diverges beam spot to provide ample functionality including the completeness of Li-Fi feature and the quality of white-lighting. The phosphorous diffuser diverged white-light spot covers a radiant angle up to 120o with CIE coordinates of (0.34, 0.37). On the other hand, the degradation on throughput frequency response of the blue LD is mainly attributed to the self-feedback caused by the reflection from the phosphor-air interface. It represents the current state-of-the-art performance on carrying 5.2-Gbit/s orthogonal frequency-division multiplexed 16-quadrature-amplitude modulation (16-QAM OFDM) data with a bit error rate (BER) of 3.1 × 10-3 over a 60-cm free-space link. This work aims to explore the plausibility of the phosphorous diffuser diverged blue GaN LD for future hybrid white-lighting and VLC systems.

Thermal dark matter from a highly decoupled sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berlin, Asher; Hooper, Dan; Krnjaic, Gordan

It has recently been shown that if the dark matter is in thermal equilibrium with a sector that is highly decoupled from the Standard Model, it can freeze out with an acceptable relic abundance, even if the dark matter is as heavy as ~1–100 PeV. In such scenarios, both the dark and visible sectors are populated after inflation, but with independent temperatures. The lightest particle in the dark sector will be generically long-lived and can come to dominate the energy density of the Universe. Upon decaying, these particles can significantly reheat the visible sector, diluting the abundance of dark mattermore » and thus allowing for dark matter particles that are much heavier than conventional WIMPs. In this study, we present a systematic and pedagogical treatment of the cosmological history in this class of models, emphasizing the simplest scenarios in which a dark matter candidate annihilates into hidden sector particles which then decay into visible matter through the vector, Higgs, or lepton portals. In each case, we find ample parameter space in which very heavy dark matter particles can provide an acceptable thermal relic abundance. We also discuss possible extensions of models featuring these dynamics.« less

Dementia and sculpture-making: Exploring artistic responses of people with dementia.

PubMed

Chauhan, Sumita

2018-01-01

In its form, sculpture reveals not only the artist's self-expression but also the transformative qualities through which it influences our senses. Frequent interactions with sculpture can provide creative awareness, which in turn leads to a better understanding and appreciation of artistic expressions. This paper examines possible ways in which the creative potential of people with dementia can be explored through meaningful artistic engagement with sculpture-making processes. A study was conducted involving seven participants diagnosed with the early stages of dementia who engaged and experimented with different types of sculpture-making processes, from clay and papier mâché to virtual and digital sculptures. In the collective and collaborative environment of the group sessions, the creative responses of the participants to each process were unique. Each sculpture created by the participants enfolded their self-initiated ideas and stories reflecting the conscious expressions of their presence in a particular time and space. This paper argues that while cognitive impairment may affect the behavioural, visual and perceptual abilities of people with dementia, there is ample evidence to suggest that the viewing and making sculpture may influence the sensory involvement and consequently the imagination and creativity of people with early stage dementia.

An Overview of SIMBIOS Program Activities and Accomplishments. Chapter 1

NASA Technical Reports Server (NTRS)

Fargion, Giulietta S.; McClain, Charles R.

2003-01-01

The SIMBIOS Program was conceived in 1994 as a result of a NASA management review of the agency's strategy for monitoring the bio-optical properties of the global ocean through space-based ocean color remote sensing. At that time, the NASA ocean color flight manifest included two data buy missions, the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) and Earth Observing System (EOS) Color, and three sensors, two Moderate Resolution Imaging Spectroradiometers (MODIS) and the Multi-angle Imaging Spectro-Radiometer (MISR), scheduled for flight on the EOS-Terra and EOS-Aqua satellites. The review led to a decision that the international assemblage of ocean color satellite systems provided ample redundancy to assure continuous global coverage, with no need for the EOS Color mission. At the same time, it was noted that non-trivial technical difficulties attended the challenge (and opportunity) of combining ocean color data from this array of independent satellite systems to form consistent and accurate global bio-optical time series products. Thus, it was announced at the October 1994 EOS Interdisciplinary Working Group meeting that some of the resources budgeted for EOS Color should be redirected into an intercalibration and validation program (McClain et al., 2002).

Novel Perceptually Uniform Chromatic Space.

PubMed

da Fonseca, María; Samengo, Inés

2018-06-01

Chromatically perceptive observers are endowed with a sense of similarity between colors. For example, two shades of green that are only slightly discriminable are perceived as similar, whereas other pairs of colors, for example, blue and yellow, typically elicit markedly different sensations. The notion of similarity need not be shared by different observers. Dichromat and trichromat subjects perceive colors differently, and two dichromats (or two trichromats, for that matter) may judge chromatic differences inconsistently. Moreover, there is ample evidence that different animal species sense colors diversely. To capture the subjective metric of color perception, here we construct a notion of distance in color space based on the physiology of the retina, and is thereby individually tailored for different observers. By applying the Fisher metric to an analytical model of color representation, we construct a notion of distance that reproduces behavioral experiments of classical discrimination tasks. We then derive a coordinate transformation that defines a new chromatic space in which the Euclidean distance between any two colors is equal to the perceptual distance, as seen by one individual subject, endowed with an arbitrary number of color-sensitive photoreceptors, each with arbitrary absorption probability curves and appearing in arbitrary proportions.

Crowdsourced Geospatial Data: A Report on the Emerging Phenomena of Crowdsourced and User-Generated Geospatial Data

DTIC Science & Technology

2012-11-01

wider context for this emerging trend. Subsequent sections of this report discuss CGD in the context of geographic information systems and...authoritative data pro- duction systems , sources and examples of CGD, data quality considera- tions for CGD, evaluating fitness-for-use of CGD, significant...geographic information systems (GIS), provide ex- amples and sources of CGD, report on the data quality of CGD, demon- strate the fitness-for-use of CGD, and

Simplified Bioreactor For Growing Mammalian Cells

NASA Technical Reports Server (NTRS)

Spaulding, Glenn F.

1995-01-01

Improved bioreactor for growing mammalian cell cultures developed. Designed to support growth of dense volumes of mammalian cells by providing ample, well-distributed flows of nutrient solution with minimal turbulence. Cells relatively delicate and, unlike bacteria, cannot withstand shear forces present in turbulent flows. Bioreactor vessel readily made in larger sizes to accommodate greater cell production quantities. Molding equipment presently used makes cylinders up to 30 centimeters long. Alternative sintered plastic techniques used to vary pore size and quantity, as necessary.

High energy neutrinos from gamma-ray bursts with precursor supernovae.

PubMed

Razzaque, Soebur; Mészáros, Peter; Waxman, Eli

2003-06-20

The high energy neutrino signature from proton-proton and photo-meson interactions in a supernova remnant shell ejected prior to a gamma-ray burst provides a test for the precursor supernova, or supranova, model of gamma-ray bursts. Protons in the supernova remnant shell and photons entrapped from a supernova explosion or a pulsar wind from a fast-rotating neutron star remnant provide ample targets for protons escaping the internal shocks of the gamma-ray burst to interact and produce high energy neutrinos. We calculate the expected neutrino fluxes, which can be detected by current and future experiments.

CESIC: a new technology for lightweight and cost effective space instrument structures and mirrors

NASA Astrophysics Data System (ADS)

Devilliers, Christophe; Kroedel, Matthias R.

2005-08-01

For some years Alcatel Space has been interested in the development of a new material to produce lightweight, stiff, stable and cost effective structures and mirrors for space instrument. Cesic from ECM has been selected for its intrinsic properties (high specific modulus, high conductivity, quite low thermal expansion coefficient and high fracture toughness for a ceramic material), added to ample manufacturing capabilities. Under ESA responsibility, a flight representative optical bench of Cesic has been designed, manufactured and tested. The optical bench has been submitted with success to intensive vibration tests up to 80 g on shaker without problem and was tested down to 30 K showing very high stability. Cesic is also envisaged for large and lightweight space telescope mirrors. Coatings on the Cesic substrate have been developed and qualified for the most stringent optical needs. To prove the lightweight capability, a large Cesic mirror D=950 mm with an area mass of less than 25 kg/m2 has been designed, sized again launch loads and WFE performance, and then manufactured. Cesic is also envisaged for large future focal plane holding a large number of detectors assuring high stability thanks to its high thermal conductivity. A full size Cesic focal plane has been already successfully built and tested. Based on these successful results, Alcatel Space is now in position to propose for space projects this technology mastered in common with ECM both for mirrors and structures with new innovative concepts thanks to the manufacturing capabilities of this technology.

Closed culture plant studies: Implications for CELSS

NASA Technical Reports Server (NTRS)

Hoshizaki, T.

1986-01-01

Arabidopsis plants were grown in closed cultures similar to those used in space experiments. A shift in metabolism from photosynthesis to respiration is indicated by the accumulation of CO2 in the culture atmosphere. Reproductive growth is suppressed. Plant growth and development is apparently related to the atmospheric volume available to each plant. The implications of these findings to closed ecological systems are given: (1) there is a need for an open culture having ample gas exchange, (2) CO2 levels must be maintained within prescribed limits, (3) the minimum atmospheric volume required for each plant is dependent on the precision of the gas monitors and of the subsystems used to maintain appropriate levels of various atmospheric components, and (4) volatiles such as ethylene and terpenes emanating from plants be monitored and reduced to benign concentrations.

Organizational Analysis of the TIDES Project and the STAR-TIDES Network Using the 7-S Framework

DTIC Science & Technology

2013-04-01

data, provided some useful rec- ommendations.8 Since that time, TIDES has continued to grow and change. The present study was undertaken to update the...information across platforms and within the secure NDU network. For ex- ample, many contacts made by the Director are preserved within his Blackberry ...the active participation of STAR-TIDES network members, and to grow the network. 5. Skills Skills refers to the talents and abilities of the

Hazards of Farming

PubMed Central

Guilfoyle, John

1992-01-01

Farming is the most dangerous occupation in the industrialized world. Children, in particular, are at high risk for injury and disability. There is ample scope to improve this situation. Parents are the most important group to be educated. Emergency response services in rural areas are sometimes unable to provide optimum care for victims. Better surveillance methods need to be in place, both to gather information and to evaluate strategies aimed at prevention. Farm safety needs to be higher on the agenda for farmers, farm organizations, government, and health care professionals. PMID:21221275

Temperature, Geochemistry, and Gravity Data of the Tularosa Basin

DOE Data Explorer

Nash, Greg

2017-06-16

This submission contains multiple excel spreadsheets and associated written reports. The datasets area are representative of shallow temperature, geochemistry, and other well logging observations made across WSMR (white sands missile range); located to the west of the Tularosa Basin but still within the study area. Written reports accompany some of the datasets, and they provide ample description of the methodology and results obtained from these studies. Gravity data is also included, as point data in a shapefile, along with a written report describing that particular study.

NASA's Space Shuttle Discovery is raised to allow ample clearance for the modified 747 Shuttle Carrier Aircraft to position underneath for attachment

NASA Image and Video Library

2005-08-18

NASA's specially modified 747 Shuttle Carrier Aircraft, or SCA, is positioned under the Space Shuttle Discovery to be attached for their ferry flight to the Kennedy Space Center in Florida. After its post-flight servicing and preparation at NASA Dryden in California, Discovery's return flight to Kennedy aboard the 747 will take approximately 2 days, with stops at several intermediate points for refueling. Space Shuttle Discovery landed safely at NASA's Dryden Flight Research Center at Edwards Air Force Base at 5:11:22 a.m. PDT, August 9, 2005, following the very successful 14-day STS-114 return to flight mission. During their two weeks in space, Commander Eileen Collins and her six crewmates tested out new safety procedures and delivered supplies and equipment the International Space Station. Discovery spent two weeks in space, where the crew demonstrated new methods to inspect and repair the Shuttle in orbit. The crew also delivered supplies, outfitted and performed maintenance on the International Space Station. A number of these tasks were conducted during three spacewalks. In an unprecedented event, spacewalkers were called upon to remove protruding gap fillers from the heat shield on Discovery's underbelly. In other spacewalk activities, astronauts installed an external platform onto the Station's Quest Airlock and replaced one of the orbital outpost's Control Moment Gyroscopes. Inside the Station, the STS-114 crew conducted joint operations with the Expedition 11 crew. They unloaded fresh supplies from the Shuttle and the Raffaello Multi-Purpose Logistics Module. Before Discovery undocked, the crews filled Raffeallo with unneeded items and returned to Shuttle payload bay. Discovery launched on July 26 and spent almost 14 days on orbit.

Floating potential of emitting surfaces in plasmas with respect to the space potential

DOE PAGES

Kraus, B. F.; Raitses, Y.

2018-03-19

The potential difference between a floating emitting surface and the plasma surrounding it has been described by several sheath models, including the space-charge-limited sheath, the electron sheath with high emission current, and the inverse sheath produced by charge-exchange ion trapping. Our measurements reveal that each of these models has its own regime of validity. We determine the potential of an emissive filament relative to the plasma potential, emphasizing variations in emitted current density and neutral particle density. The potential of a filament in a diffuse plasma is first shown to vanish, consistent with the electron sheath model and increasing electronmore » emission. In a denser plasma with ample neutral pressure, the floating filament potential is positive, as predicted by a derived ion trapping condition. In conclusion, the filament floated negatively in a third plasma, where flowing ions and electrons and nonnegligible electric fields may have disrupted ion trapping. Depending on the regime chosen, emitting surfaces can float positively or negatively with respect to the plasma potential.« less

Availability and quality of ground water in the Piedmont Province of Virginia

USGS Publications Warehouse

Powell, John Duane; Abe, Joseph M.

1985-01-01

The Piedmont Province of Virginia has an ample supply of groundwater, (perhaps as much as 1.5 billion gallons are in storage per sq mi) generally suitable for domestic and small supply needs. The source of this groundwater is precipitation, which is stored in the pore spaces of the regolith and in fractures in the underlying bedrock of crystalline rocks. Water within the sedimentary rocks of the sedimentary basins is stored in bedding planes, fractures, and in pore spaces in the rock, and in the regolith. Well yields can be minimized in both terrains by constructing wells along lineaments and in valleys. Groundwater in the crystalline rock is generally slightly mineralized and acidic (pH is greater than 7.0). Dissolved solids concentration in deep wells ( < 500 ft) in sedimentary rock may exceed tolerable limits. Land disposal of solid wastes and sewage for domestic septic systems present the major threat to groundwater quality. A greater understanding of the groundwater system in the Virginia Piedmont could be used to anticipate future shortages so that preventive measures could be implemented to protect the groundwater reservoir. (Author 's abstract)

Floating potential of emitting surfaces in plasmas with respect to the space potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, B. F.; Raitses, Y.

The potential difference between a floating emitting surface and the plasma surrounding it has been described by several sheath models, including the space-charge-limited sheath, the electron sheath with high emission current, and the inverse sheath produced by charge-exchange ion trapping. Our measurements reveal that each of these models has its own regime of validity. We determine the potential of an emissive filament relative to the plasma potential, emphasizing variations in emitted current density and neutral particle density. The potential of a filament in a diffuse plasma is first shown to vanish, consistent with the electron sheath model and increasing electronmore » emission. In a denser plasma with ample neutral pressure, the floating filament potential is positive, as predicted by a derived ion trapping condition. In conclusion, the filament floated negatively in a third plasma, where flowing ions and electrons and nonnegligible electric fields may have disrupted ion trapping. Depending on the regime chosen, emitting surfaces can float positively or negatively with respect to the plasma potential.« less

An ethical duty: Let astronautical development unfold - to make the people more secure

NASA Astrophysics Data System (ADS)

Bernasconi, Marco C.

2014-11-01

In examining alternative space-development models, one observes that Heinlein postulated the first Moon flight as the outcome of the focused action of an individual - building upon an ample commercial aerospace transportation infrastructure. The same technological basis and entrepreneurial drive would then sustain a fast human and economic expansion on three new planets. Instead, historically, humans reached the Moon thanks to a "Faustian bargain" between astronautical developers and governments. This approach brought the early Apollo triumphs, but it also created the presumption of this method as the sole one for enabling space development. Eventually, the application of this paradigm caused the decline of the astronautical endeavor. Thus, just as conventional methods became unable to sustain the astronautical endeavor, space development appeared as vital, e.g., to satisfy the people's basic needs (metabolic resources, energy, materials, and space), as shown elsewhere. Such an endeavor must grow from actions generating new wealth through commercial activities to become self-supporting. Acquisition and distribution of multiform space resources call, however, for a sound ethical environment, as predatory governments can easily forfeit those resources. The paper begins the search for means apt to maintain a societal environment suited for this purpose. Among numerous initiatives needed, dissemination of factual information and moral-right education support take a central position: In fact, the vital condition for true Astronautics - a vast increase in actual respect of moral rights - can also become its best consequence, as the prosperity from the space arena empowers the people, making them materially safer and more secure in their fundamental moral rights.

Chances and challenges of forest scale CO2 enrichment

NASA Astrophysics Data System (ADS)

Körner, Christian

2016-04-01

Rising CO2 is changing the biosphere's diet. As with any dietary change, both amount and quality of food matter. Atmospheric CO2 enrichment is clearly providing a rather one-sided, C-rich diet. Hence, the reaiistic experimental simulation of its effect on the single biggest C reservoir of the biosphere, that is forest, requires experimental conditions that resemble exactly that situation. In the past, trees where most commonly exposed to elevated CO2 while provided with ample other constituents of a plant's diet (soil nutrients), yielding exaggerated growth stimulation, unlikely to reflect real world responses. So, by either selecting fertile soils, disturbing the system by fire or planting activities, offering ample soil space to isolated individuals or even adding fertilizer, almost any CO2-response can be 'designed'. The 'art' of designing future Free Air CO2 Enrichment (FACE) experiments will be to avoid exactly these pitfalls. Plants can incorporate additional C only to the extent the provision of chemical elements other than C will permit, given the stoichiometry of life. Site selection (soil fertility), degree of canopy closure, recent disturbance regime or successional stage will influence CO2 effects. It is the fundamental dilemma in CO2-enrichment research that simple, homogenous, artificial test systems offer statistical power, while systems that account for 'naturalness' and species diversity do not. Any new FACE program needs to handle that tradeoff between precision and relevance. In this presentation I will advocate a pragmatic approach that will inevitably have to lean on individual tree responses, across a wide as possible range of neighborhoods, age and growth conditions, with the statistical power depending in obtaining the best possible pre-treatment traits and responses. By illustrating the results of 15 years of FACE with 30-40 m tall forest trees, I will caution against over-optimistic ecosystem scale approaches with just ONE technology, given the sheer size such test systems would require. I rather suggest combining the best choice technology at different scales, which is not necessarily the most costly FACE approach. FACE emerged from overestimating potential bias from atmospheric conditions and greatly unerestimating the key role of soil conditions and biodiversity. Reference: Körner C (2006) Plant CO2 responses: an issue of definition, time and resource supply. New Phytol 172:393-411. Bader MKF, et al. (2013) Central European hardwood trees in a high-CO2 future: synthesis of an 8-year forest canopy CO2 enrichment project. J Ecol 101:1509-1519.

[News and advertising on foods, diet and obesity].

PubMed

di Diodoro, Danilo

2005-03-01

In recent decades a new ideal of beauty has evolved characterised by slim women and muscular men; obesity, which in past centuries was considered healthy and attractive, is now "out of fashion". The news media devote ample space, especially during spring and summer, to diet and fitness programs, and many diets and devices, without any scientific evidence, are presented as miracle cures. The business of diets and "natural" products generates intensive campaigns developed to promote foods, nutritional programs, and specific tools for losing weight as rapidly and effortlessly as possible. In this context, general practitioners and specialists have a fundamental role to play in correcting the often distorted messages that the general public receives, through educational programs designed to promote a correct understanding of the cardiovascular risks of obesity and healty methods and treatments for losing weight and safely achieving real health objectives.

The Play Experiences of Preschool Children from a Low-socio-economic Rural Community in Worcester, South Africa.

PubMed

Bartie, Michelle; Dunnell, Alex; Kaplan, Jesse; Oosthuizen, Dianka; Smit, Danielle; van Dyk, Anchen; Cloete, Lizahn; Duvenage, Mia

2016-06-01

Occupational therapists believe that play is a child's main occupation and is considered essential for healthy motor, cognitive and emotional development. However, play spaces and activities in low socio-economic areas are often different to those provided in structured occupational therapy treatment environments. The main objective was to determine play opportunities, activities, equipment, toys and the play environment for 5- to 6-year-olds living in a low-socio-economic community outside a small town in South Africa, in order to understand the nature of play in this environment better. Participant observation together with an adapted photovoice method to capture the play experience was used. Data was analysed using inductive content analysis. Two global themes emerged from the results: "neighbourhood children find ways to play" and "context influences play". Children were given ample opportunity to play and participated in extensive outdoor play. Their games were highly social and involved the imaginative use of found items as toys. Play was also used to make sense of social hazards. An understanding of play in a low-income context has implications for the development of future play assessments and the provision of play therapy in these communities. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

[What is purchased, how and from whom by Seguro Popular in Mexico? Experience with strategic purchasing at national level and in a pioneer institution].

PubMed

González-Block, Miguel Ángel

2017-01-01

To analyze the scope of demand subsidies through strategic purchasing of health services. Interviews and document analyses at national level and a case study of the state of Hidalgo. SPSS explicitly prioritizes interventions to be financed and regulates prices and expenditure ceilings. Public providers are predominantly funded through the purchasing of inputs and the contracting of human resources, in the absence of competition and with a low degree of managerial autonomy. Seguro Popular in Hidalgo has diversified service providers and payment mechanisms. SPSS has ample opportunity to extend and deepen strategic purchasing. Greater decision-making autonomy of payers and providers is required, as well as regulations to promote provider networks in competitive environments.

On the onset of secondary flow and unsteady solutions through a loosely coiled rectangular duct for large aspect ratio

NASA Astrophysics Data System (ADS)

Shaha, Poly Rani; Rudro, Sajal Kanti; Poddar, Nayan Kumar; Mondal, Rabindra Nath

2016-07-01

The study of flows through coiled ducts and channels has attracted considerable attention not only because of their ample applications in Chemical, Mechanical, Civil, Nuclear and Biomechanical engineering but also because of their ample applications in other areas, such as blood flow in the veins and arteries of human and other animals. In this paper, a numerical study is presented for the fully developed two-dimensional flow of viscous incompressible fluid through a loosely coiled rectangular duct of large aspect ratio. Numerical calculations are carried out by using a spectral method, and covering a wide range of the Dean number, Dn, for two types of curvatures of the duct. The main concern of the present study is to find out effects of curvature as well as formation of secondary vortices on unsteady solutions whether the unsteady flow is steady-state, periodic, multi-periodic or chaotic, if Dn is increased. Time evolution calculations as well as their phase spaces are performed with a view to study the non-linear behavior of the unsteady solutions, and it is found that the steady-state flow turns into chaotic flow through various flow instabilities, if Dn is increased no matter what the curvature is. It is found that the unsteady flow is a steady-state solution for small Dn's and oscillates periodically or non-periodically (chaotic) between two- and twelve-vortex solutions, if Dn is increased. It is also found that the chaotic solution is weak for small Dn's but strong as Dn becomes large. Axial flow distribution is also investigated and shown in contour plots.

On the onset of secondary flow and unsteady solutions through a loosely coiled rectangular duct for large aspect ratio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaha, Poly Rani; Poddar, Nayan Kumar; Mondal, Rabindra Nath, E-mail: rnmondal71@yahoo.com

The study of flows through coiled ducts and channels has attracted considerable attention not only because of their ample applications in Chemical, Mechanical, Civil, Nuclear and Biomechanical engineering but also because of their ample applications in other areas, such as blood flow in the veins and arteries of human and other animals. In this paper, a numerical study is presented for the fully developed two-dimensional flow of viscous incompressible fluid through a loosely coiled rectangular duct of large aspect ratio. Numerical calculations are carried out by using a spectral method, and covering a wide range of the Dean number, Dn,more » for two types of curvatures of the duct. The main concern of the present study is to find out effects of curvature as well as formation of secondary vortices on unsteady solutions whether the unsteady flow is steady-state, periodic, multi-periodic or chaotic, if Dn is increased. Time evolution calculations as well as their phase spaces are performed with a view to study the non-linear behavior of the unsteady solutions, and it is found that the steady-state flow turns into chaotic flow through various flow instabilities, if Dn is increased no matter what the curvature is. It is found that the unsteady flow is a steady-state solution for small Dn’s and oscillates periodically or non-periodically (chaotic) between two- and twelve-vortex solutions, if Dn is increased. It is also found that the chaotic solution is weak for small Dn’s but strong as Dn becomes large. Axial flow distribution is also investigated and shown in contour plots.« less

Public-Private Ventures in Bachelor Quarters: A Solution to the Loss of Military Construction Projects. Volume 1. Findings, Conclusions, and Recommendations

DTIC Science & Technology

1990-06-01

restaurants, and other amenities. Although the food and beverage facilities at the National Medical Center are ample, they are not targeted for the...against including a club and restaurant in the BOQ project. Current on-base food and beverage facilities are sufficient to serve the additional demand that...taxing its capacity. In fact, tlie base has six food and beverage facilities that provide a variety of choices, and adding a seventh in the BOQ would

Analytical expressions for the nonlinear interference in dispersion managed transmission coherent optical systems

NASA Astrophysics Data System (ADS)

Qiao, Yaojun; Li, Ming; Yang, Qiuhong; Xu, Yanfei; Ji, Yuefeng

2015-01-01

Closed-form expressions of nonlinear interference of dense wavelength-division-multiplexed (WDM) systems with dispersion managed transmission (DMT) are derived. We carry out a simulative validation by addressing an ample and significant set of the Nyquist-WDM systems based on polarization multiplexed quadrature phase-shift keying (PM-QPSK) subcarriers at a baud rate of 32 Gbaud per channel. Simulation results show the simple closed-form analytical expressions can provide an effective tool for the quick and accurate prediction of system performance in DMT coherent optical systems.

Caught in the Solar Wind: A Study of Space Weather and its Influence on Earth

NASA Astrophysics Data System (ADS)

Hill, R.; Chuckran, A.; Erickson, P. J.

2007-12-01

Space weather is a phenomenon that is becoming more familiar to the general public. As people are increasingly reliant on 21st century technology, the potential for disruption to their daily lives also rises. As the sun approaches its next solar maximum in 2011 or 2012, the peak of Cycle 24 is expected to be the highest of the satellite age, perhaps surpassing that of Cycle 19 in 1957-58. In this teaching unit, we have attempted to create a series of lessons that sheds light on the concept of space weather and the sun's influences on earth's magnetic field and upper atmosphere. Within this unit, we have provided ample opportunities for students to access and interpret real scientific data from a variety of sources. The main location is the web site www.spaceweather.com , which has near real time data from satellites such as SOHO, STEREO, ACE and POES. This data is easily viewed and explained within the site, and with appropriate instruction, students can regularly gather data, make predictions, and draw conclusions based on the current behavior of the sun. Examples include sunspot number and development, speed and density of solar wind, orientation and strength of the interplanetary magnetic field, location of coronal holes, planetary K index and X-ray solar flares. Depending on the level of the students, some or all of this data can be compiled over a period of time to better understand the behavior of the sun as well as its influence on Earth. The goal of this unit is to provide a vehicle for students to understand how data is used by scientists. Once they have the base knowledge, students may be able to construct their own questions and follow through with research. An inquiry-based approach is incorporated whenever possible. With the onset of a potentially active solar cycle in the near future, teachers have the opportunity to make a dramatic connection between the natural world and their daily lives. Solar storms can cause disruption to telephone communication, television, GPS systems and power grids, as well as provide dazzling auroral displays. If Cycle 24 lives up to the predictions, space weather will be a newsworthy story and a teachable moment. Many of the activities in this unit have been tested already and all will have been used with high school students by the time of the AGU meeting. Our discussion will include samples of student work and an evaluation of the success of the unit's ability to incorporate current scientific data into the classroom.

Designing for Reliability and Robustness

NASA Technical Reports Server (NTRS)

Svetlik, Randall G.; Moore, Cherice; Williams, Antony

2017-01-01

Long duration spaceflight has a negative effect on the human body, and exercise countermeasures are used on-board the International Space Station (ISS) to minimize bone and muscle loss, combatting these effects. Given the importance of these hardware systems to the health of the crew, this equipment must continue to be readily available. Designing spaceflight exercise hardware to meet high reliability and availability standards has proven to be challenging throughout the time the crewmembers have been living on ISS beginning in 2000. Furthermore, restoring operational capability after a failure is clearly time-critical, but can be problematic given the challenges of troubleshooting the problem from 220 miles away. Several best-practices have been leveraged in seeking to maximize availability of these exercise systems, including designing for robustness, implementing diagnostic instrumentation, relying on user feedback, and providing ample maintenance and sparing. These factors have enhanced the reliability of hardware systems, and therefore have contributed to keeping the crewmembers healthy upon return to Earth. This paper will review the failure history for three spaceflight exercise countermeasure systems identifying lessons learned that can help improve future systems. Specifically, the Treadmill with Vibration Isolation and Stabilization System (TVIS), Cycle Ergometer with Vibration Isolation and Stabilization System (CEVIS), and the Advanced Resistive Exercise Device (ARED) will be reviewed, analyzed, and conclusions identified so as to provide guidance for improving future exercise hardware designs. These lessons learned, paired with thorough testing, offer a path towards reduced system down-time.

Motor Imagery and Tennis Serve Performance: The External Focus Efficacy

PubMed Central

Guillot, Aymeric; Desliens, Simon; Rouyer, Christelle; Rogowski, Isabelle

2013-01-01

There is now ample evidence that motor imagery (MI) contributes to enhance motor performance. Previous research also demonstrated that directing athletes’ attention to the effects of their movements on the environment is more effective than focusing on the action per se. The present study aimed therefore at evaluating whether adopting an external focus during MI contributes to enhance tennis serve performance. Twelve high-level young tennis players were included in a test-retest procedure. The effects of regular training were first evaluated. Then, players were subjected to a MI intervention during which they mentally focused on ball trajectory and specifically visualized the space above the net where the serve can be successfully hit. Serve performance was evaluated during both a validated serve test and a real match. The main results showed a significant increase in accuracy and velocity during the ecological serve test after MI practice, as well as a significant improvement in successful first serves and won points during the match. Present data therefore confirmed the efficacy of MI in combination of physical practice to improve tennis serve performance, and further provided evidence that it is feasible to adopt external attentional focus during MI. Practical applications are discussed. Key Points Motor imagery contributes to enhance tennis serve performance. Data provided evidence of the benefits of adopting an external focus of attention during imagery. Results showed significant improvement in successful first serves and won points during a real match. PMID:24149813

[Retrospect of Chinese herbs taken as tea drinking].

PubMed

Zhu, J N; Zhang, X L; Guo, H

2017-01-28

Tea and wine are time-honored drinks in China. Along with coffee and cocoa, tea, as one of the non-alcoholic plant beverages, is prevailing the world. Tea and Chinese medicine has a very close relationship. Chinese herbs taken as tea forming the tea-like medicinal tea, can be taken frequently at anytime. The application of Chinese herbs taken as tea drinking begins from the Tang Dynasty, flourishes in the Song Dynasty and matures in the Qing Dynasty. The review of its history provides ample evidence of Chinese herbs taken as tea drinking in treating and preventing diseases, as well as providing the clues and references of developing new Chinese herbs taking as tea.

A place-based model of local activity spaces: individual place exposure and characteristics

NASA Astrophysics Data System (ADS)

Hasanzadeh, Kamyar; Laatikainen, Tiina; Kyttä, Marketta

2018-01-01

Researchers for long have hypothesized relationships between mobility, urban context, and health. Despite the ample amount of discussions, the empirical findings corroborating such associations remain to be marginal in the literature. It is growingly believed that the weakness of the observed associations can be largely explained by the common misspecification of the geographical context. Researchers coming from different fields have developed a wide range of methods for estimating the extents of these geographical contexts. In this article, we argue that no single approach yet has sufficiently been capable of capturing the complexity of human mobility patterns. Subsequently, we discuss that reaching a better understanding of individual activity spaces can be possible through a spatially sensitive estimation of place exposure. Following this discussion, we take an integrative person and place-based approach to create an individualized residential exposure model (IREM) to estimate the local activity spaces (LAS) of the individuals. This model is created using data collected through public participation GIS. Following a brief comparison of IREM with other commonly used LAS models, the article continues by presenting an empirical study of aging citizens in Helsinki area to demonstrate the usability of the proposed framework. In this study, we identify the main dimensions of LASs and seek their associations with socio-demographic characteristics of individuals and their location in the region. The promising results from comparisons and the interesting findings from the empirical part suggest both a methodological and conceptual improvement in capturing the complexity of local activity spaces.

Aeronautical audio broadcasting via satellite

NASA Technical Reports Server (NTRS)

Tzeng, Forrest F.

1993-01-01

A system design for aeronautical audio broadcasting, with C-band uplink and L-band downlink, via Inmarsat space segments is presented. Near-transparent-quality compression of 5-kHz bandwidth audio at 20.5 kbit/s is achieved based on a hybrid technique employing linear predictive modeling and transform-domain residual quantization. Concatenated Reed-Solomon/convolutional codes with quadrature phase shift keying are selected for bandwidth and power efficiency. RF bandwidth at 25 kHz per channel, and a decoded bit error rate at 10(exp -6) with E(sub b)/N(sub o) at 3.75 dB are obtained. An interleaver, scrambler, modem synchronization, and frame format were designed, and frequency-division multiple access was selected over code-division multiple access. A link budget computation based on a worst-case scenario indicates sufficient system power margins. Transponder occupancy analysis for 72 audio channels demonstrates ample remaining capacity to accommodate emerging aeronautical services.

Immune Function Changes during a Spaceflight-Analog Undersea Mission

NASA Technical Reports Server (NTRS)

Crucian, Brian; Stowe, Raymond; Mehta, Satish; Quiniarte, Heather; Yetman, Deborah; Pierson, Duane; Sams, Clarence

2008-01-01

There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. It is attractive to utilize ground-based spaceflight analogs as appropriate to investigate this phenomenon. For spaceflight-associated immune dysregulation (SAID), the authors believe the most appropriate analogs might be NEEMO (short duration, Shuttle analog), Antarctic winter-over (long-duration, ISS analog) and the Haughton Mars Project in the Canadian Arctic (intermediate-duration). Each of these analogs replicate isolation, mission-associated stress, disrupted circadian rhythms, and other aspects of flight thought to contribute to SAID. To validate NEEMO as a flight analog with respect to SAID, a pilot study was conducted during the NEEMO-12 and 13 missions during 2007. Assays were performed that assessed immune status, physiological stress and latent viral reactivation. Blood and saliva samples were collected at pre-, mid-, and post-mission timepoints.

Possibilities to improve the aircraft interior comfort experience.

PubMed

Vink, P; Bazley, C; Kamp, I; Blok, M

2012-03-01

Comfort plays an increasingly important role in the interior design of airplanes. Although ample research has been conducted on airplane design technology, only a small amount of public scientific information is available addressing the passenger's opinion. In this study, more than 10,000 internet trip reports and 153 passenger interviews were used to gather opinions about aspects which need to be improved in order to design a more comfortable aircraft interior. The results show clear relationships between comfort and legroom, hygiene, crew attention and seat/personal space. Passengers rate the newer planes significantly better than older ones, indicating that attention to design for comfort has proven effective. The study also shows that rude flight attendants and bad hygiene reduce the comfort experience drastically and that a high comfort rating is related to higher "fly again" values. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Achromatic beam transport of High Current Injector

NASA Astrophysics Data System (ADS)

Kumar, Sarvesh; Mandal, A.

2016-02-01

The high current injector (HCI) provides intense ion beams of high charge state using a high temperature superconducting ECR ion source. The ion beam is accelerated upto a final energy of 1.8 MeV/u due to an electrostatic potential, a radio frequency quadrupole (RFQ) and a drift tube linac (DTL). The ion beam has to be transported to superconducting LINAC which is around 50 m away from DTL. This section is termed as high energy beam transport section (HEBT) and is used to match the beam both in transverse and longitudinal phase space to the entrance of LINAC. The HEBT section is made up of four 90 deg. achromatic bends and interconnecting magnetic quadrupole triplets. Two RF bunchers have been used for longitudinal phase matching to the LINAC. The ion optical design of HEBT section has been simulated using different beam dynamics codes like TRACEWIN, GICOSY and TRACE 3D. The field computation code OPERA 3D has been utilized for hardware design of all the magnets. All the dipole and quadrupole magnets have been field mapped and their test results such as edge angles measurements, homogeneity and harmonic analysis etc. are reported. The whole design of HEBT section has been performed such that the most of the beam optical components share same hardware design and there is ample space for beam diagnostics as per geometry of the building. Many combination of achromatic bends have been simulated to transport the beam in HEBT section but finally the four 90 deg. achromatic bend configuration is found to be the best satisfying all the geometrical constraints with simplified beam tuning process in real time.

The 1990 Western Pacific Geophysics meeting

NASA Technical Reports Server (NTRS)

1990-01-01

The 1990 Western Pacific Geophysics Meeting was held in Kanazawa, Japan from 15-21 Aug. 1990. This was the first meeting of a new series of meetings for the American Geophysical Union, and it proved to be very successful in terms of the scientific program and attendance, which included over 1,000 participants. The intent of this meeting was an effort on the part of the American Geophysical Union (AGU) and several Japanese geophysical societies to gather individual Earth and space scientists at a major scientific meeting to focus on geophysical problems being studied in the western Pacific rim. The meeting was organized along the lines of a typical AGU annual meeting with some invited talks, many contributed talks, poster sessions, and with emphasis on presentations and informal discussions. The program committee consisted of scientists from both the U.S. and Japan. This meeting provided ample opportunities for U.S. and Japanese scientists to get to know each other and their works on a one-to-one basis. It was also a valuable opportunity for students studying geophysics to get together and interact with each other and with scientists from both the U.S. and Japan. There were 939 abstracts submitted to the conference and a total of 102 sessions designed as a result of the abstracts received. The topics of interest are as follows: space geodetic and observatory measurements for earthquake and tectonic studies; gravity, sea level, and vertical motion; variations in earth rotation and earth dynamics; sedimentary magnetism; global processes and precipitation; subsurface contaminant transport; U.S. Western Pacific Rim initiatives in hydrology; shelf and coastal circulation; tectonics, magmatism, and hydrothermal processes; earthquake prediction and hazard assessment; seismic wave propagation in realistic media; and dynamics and structure of plate boundaries and of the Earth's deep interior.

Loss of live coral compromises predator-avoidance behaviour in coral reef damselfish.

PubMed

Boström-Einarsson, Lisa; Bonin, Mary C; Munday, Philip L; Jones, Geoffrey P

2018-05-17

Tropical reefs have experienced an unprecedented loss of live coral in the past few decades and the biodiversity of coral-dependent species is under threat. Many reef fish species decline in abundance as coral cover is lost, yet the mechanisms responsible for these losses are largely unknown. A commonly hypothesised cause of fish decline is the loss of shelter space between branches as dead corals become overgrown by algae. Here we tested this hypothesis by quantifying changes in predator-avoidance behaviour of a common damselfish, Pomacentrus moluccensis, before and after the death of their coral colony. Groups of P. moluccensis were placed on either healthy or degraded coral colonies, startled using a visual stimulus and their sheltering responses compared over a 7-week period. P. moluccensis stopped sheltering amongst the coral branches immediately following the death of the coral, despite the presence of ample shelter space. Instead, most individuals swam away from the dead coral, potentially increasing their exposure to predators. It appears that the presence of live coral rather than shelter per se is the necessary cue that elicits the appropriate behavioural response to potential predators. The disruption of this link poses an immediate threat to coral-associated fishes on degrading reefs.

Tevatron optics with magnet moves for Roman pots at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

John A. Johnstone

2001-08-16

CDF would like to install high precision track detectors. There is ample room on A-sector side, but space needs to be created at B11. The favored plan is to shove the first 3 B11 dipoles inwards toward the IP by 2.274 m. This would require removal of the inert Q1 quadrupole and its spool plus an extensive number of other mechanical and cryogenic modifications. The orbit distortion these modifications introduce would then be compensated by shifting the six B16 and B17 dipoles outwards by about half that amount. Space for this dipole move could be generated by replacing the 72more » inch spool at B18 with a short 43 inch spool, and removing the 16.5 inch spacer after B17-5. The above scheme certainly recloses the orbit, and doesn't require the detector to move. However, by moving the B16 and B17 dipoles, the B17 and B18 arc quadrupoles also get shifted downstream--B17 by 1.115 m, and B18 by 0.696 m. Longitudinal movements of arc quads by such large fractions of their magnetic lengths will clearly impact the overall machine optics.« less

The current state of electronic health record (EHR) use in Oklahoma.

PubMed

Khaliq, Amir A; Mwachofi, Ari K; Hughes, Danny R; Broyles, Robert W; Wheeler, Denna; Roswell, Robert H

2013-02-01

There is ample evidence of the positive impact of electronic health records (EHR) on operational efficiencies and quality of care. Yet, growth in the adoption of EHR and sharing of information among providers has been slow. The Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 provides financial incentives for eligible providers to adopt and implement EHR. Until now, little information was available regarding the use of EHR in Oklahoma. Sponsored by the Oklahoma Health Information Exchange Trust (OHIET), this study reveals that the frequency of use of EHR among Oklahoma providers is near the national average. Although a large number of Oklahoma physicians have received Medicaid incentive payments for planned adoption, implementation, or upgrade of EHR systems, relatively few eligible providers in Oklahoma have been certified to receive Medicare incentive payments through the Centers for Medicare and Medicaid Services (CMS) and even fewer have actually received these incentive payments.

STS-114: Engine Cut-Off Sensors Are a No-Go: Teaching Notes for NASA Case Study

NASA Technical Reports Server (NTRS)

Ransom, Khadijah S.; Johnson, Grace K.

2013-01-01

This case study format is intended to simulate the experience of facing the same difficult challenges and making the same critical decisions as managers, engineers, and scientists in the Space Shuttle Program. It has been designed for use in the classroom setting to help students develop skills related to decision-making. Students will read about the engine cut-off sensor anomaly which created challenges during the STS-114 mission and have the opportunity to make decisions as lead NASA engineers and Mission Management Team members. Included within this document are three case study presentation options - class discussion, group activity, and open-ended research. Please read the full case prior to in-class presentation to allow ample time for students' analysis and reflection, as well as to prepare additional questions. activities or exercises, material selection, etc. Depending upon the setting of your presentation and the number of participants, please choose at least one presentation format beforehand and plan accordingly. You may expect the following learning objectives by using the proposed formats. Learning Objectives: To enable students to experience the responsibilities of NASA management, engineers, and analysis; to discover possible procedures for investigating system anomalies; to become familiar with the liquid hydrogen low level engine cut-off sensor, including its function, connecting components, and location within the Space Shuttle; and to encourage critical analysis and stimulating discussion of Space Shuttle mission challenges.

Pancreatic Cancer Chemoprevention by Phytochemicals

PubMed Central

Boreddy, Srinivas Reddy; Srivastava, Sanjay K.

2012-01-01

Pancreatic cancer is fourth leading cause of cancer-related deaths in the United States of America. In spite of recent advances in the current therapeutic modalities such as surgery, radiation and chemotherapy patients, the average five year survival rate remains still less than 5%. Recently, compounds from natural sources receive ample of attention as anti-cancer agents. Many epidemiological studies published over the past few decades provide a strong correlation between consumption of vegetables, fruits or plant derived products and reduced incidence of cancer. The present review focuses on the potential antitumor effects of various natural products. PMID:23111102

An asymptotic induced numerical method for the convection-diffusion-reaction equation

NASA Technical Reports Server (NTRS)

Scroggs, Jeffrey S.; Sorensen, Danny C.

1988-01-01

A parallel algorithm for the efficient solution of a time dependent reaction convection diffusion equation with small parameter on the diffusion term is presented. The method is based on a domain decomposition that is dictated by singular perturbation analysis. The analysis is used to determine regions where certain reduced equations may be solved in place of the full equation. Parallelism is evident at two levels. Domain decomposition provides parallelism at the highest level, and within each domain there is ample opportunity to exploit parallelism. Run time results demonstrate the viability of the method.

Temporal Methods to Detect Content-Based Anomalies in Social Media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skryzalin, Jacek; Field, Jr., Richard; Fisher, Andrew N.

Here, we develop a method for time-dependent topic tracking and meme trending in social media. Our objective is to identify time periods whose content differs signifcantly from normal, and we utilize two techniques to do so. The first is an information-theoretic analysis of the distributions of terms emitted during different periods of time. In the second, we cluster documents from each time period and analyze the tightness of each clustering. We also discuss a method of combining the scores created by each technique, and we provide ample empirical analysis of our methodology on various Twitter datasets.

RESIDUAL RISK ASSESSMENT: MAGNETIC TAPE ...

EPA Pesticide Factsheets

This document describes the residual risk assessment for the Magnetic Tape Manufacturing source category. For stationary sources, section 112 (f) of the Clean Air Act requires EPA to assess risks to human health and the environment following implementation of technology-based control standards. If these technology-based control standards do not provide an ample margin of safety, then EPA is required to promulgate addtional standards. This document describes the methodology and results of the residual risk assessment performed for the Magnetic Tape Manufacturing source category. The results of this analyiss will assist EPA in determining whether a residual risk rule for this source category is appropriate.

Cabin-fuselage-wing structural design concept with engine installation

NASA Technical Reports Server (NTRS)

Ariotti, Scott; Garner, M.; Cepeda, A.; Vieira, J.; Bolton, D.

1993-01-01

The purpose of this project is to provide a fuselage structural assembly and wing structural design that will be able to withstand the given operational parameters and loads provided by Federal Aviation Regulation Part 23 (FAR 23) and the Statement of Work (SOW). The goal is to provide a durable lightweight structure that will transfer the applied loads through the most efficient load path. Areas of producibility and maintainability of the structure will also be addressed. All of the structural members will also meet or exceed the desired loading criteria, along with providing adequate stiffness, reliability, and fatigue life as stated in the SOW. Considerations need to be made for control system routing and cabin heating/ventilation. The goal of the wing structure and carry through structure is also to provide a simple, lightweight structure that will transfer the aerodynamic forces produced by the wing, tailboom, and landing gear. These forces will be channeled through various internal structures sized for the pre-determined loading criteria. Other considerations were to include space for flaps, ailerons, fuel tanks, and electrical and control system routing. The difficulties encountered in the fuselage design include expanding the fuselage cabin to accept a third occupant in a staggered configuration and providing ample volume for their safety. By adding a third person the CG of aircraft will move forward so the engine needs to be moved aft to compensate for the difference in the moment. This required the provisions of a ring frame structure for the new position of the engine mount. The difficulties encountered in the wing structural design include resizing the wing for the increased capacity and weight, and compensating for a large torsion produced by the tail boom by placing a great number of stiffeners inside the boom, which will result in the relocation of the fuel tank. Finally, an adequate carry through structure for the wing and fuselage interface will be designed to effectively transmit loads through the fuselage.

A PERMEABLE ACTIVE AMENDMENT CONCRETE (PAAC) FOR CONTAMINANT REMEDIATION AND EROSION CONTROL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knox, A.; Paller, M.; Dixon, K.

2012-06-29

The final project report for SEED SERDP ER - 2134 describes the development of permeable active amendment concrete (PAAC), which was evaluated through four tasks: 1) development of PAAC; 2) assessment of PAAC for contaminant removal; 3) evaluation of promising PAAC formulations for potential environmental impacts; and 4) assessment of the hydraulic, physical, and structural properties of PAAC. Conventional permeable concrete (often referred to as pervious concrete) is concrete with high porosity as a result of an extensive and interconnected void content. It is made from carefully controlled amounts of water and cementitious materials used to create a paste thatmore » forms a coating around aggregate particles. The mixture has a substantial void content (e.g., 15% - 25%) that results in a highly permeable structure that drains quickly. In PAAC, the aggregate material is partly replaced by chemically-active amendments that precipitate or adsorb contaminants in water that flows through the concrete interstices. PAAC combines the relatively high structural strength, ample void space, and water permeability of pervious concrete with the contaminant sequestration ability of chemically-active amendments to produce a new material with superior durability and ability to control contaminant mobility. The high surface area provided by the concrete interstices in PAAC provides significant opportunity for contaminants to react with the amendments incorporated into the concrete matrix. PAAC has the potential to immobilize a large variety of organic and inorganic contaminants by incorporating different active sequestering agents including phosphate materials (rock phosphate), organoclays, zeolite, and lime individually or in combinations.« less

Comparison of BRDF-Predicted and Observed Light Curves of GEO Satellites

NASA Astrophysics Data System (ADS)

Ceniceros, A.; Dao, P.; Gaylor, D.; Rast, R.; Anderson, J.; Pinon, E., III

Although the amount of light received by sensors on the ground from Resident Space Objects (RSOs) in geostationary orbit (GEO) is small, information can still be extracted in the form of light curves (temporal brightness or apparent magnitude). Previous research has shown promising results in determining RSO characteristics such as shape, size, reflectivity, and attitude by processing simulated light curve data with various estimation algorithms. These simulated light curves have been produced using one of several existing analytic Bidirectional Reflectance Distribution Function (BRDF) models. These BRDF models have generally come from researchers in computer graphics and machine vision and have not been shown to be realistic for telescope observations of RSOs in GEO. While BRDFs have been used for SSA analysis and characterization, there is a lack of research on the validation of BRDFs with regards to real data. In this paper, we compared telescope data provided by the Air Force Research Laboratory (AFRL) with predicted light curves from the Ashikhmin-Premoze BRDF and two additional popular illumination models, Ashikhmin-Shirley and Cook-Torrance. We computed predicted light curves based on two line mean elements (TLEs), shape model, attitude profile, observing ground station location, observation time and BRDF. The predicted light curves were then compared with AFRL telescope data. The selected BRDFS provided accurate apparent magnitude trends and behavior, but uncertainties due to lack of attitude information and deficiencies in our satellite model prevented us from obtaining a better match to the real data. The current findings present a foundation for ample future research.

Earth observation taken by the Expedition 28 crew

NASA Image and Video Library

2011-09-06

ISS028-E-037978 (6 Sept. 2011) --- Wildfire smoke plumes in Texas are featured in this image photographed by an Expedition 28 crew member on the International Space Station. This panoramic view of east-central Texas highlights numerous smoke plumes caused by wildfires burning across the state. The image was taken using a short focal length lens (12-mm), which captures a wide field of view at the cost of fine feature resolution. Smoke plumes are clearly visible in the image to the east of Austin; to the north of Houston; to the northwest of Lake Sam Rayburn and Toledo Bend Reservoir; and to the west of Shreveport, LA. More diffuse smoke moving offshore into the Gulf of Mexico is visible at bottom. Part of an ISS photovoltaic radiator panel is visible at top center. Record-setting drought conditions have affected much of Texas since early 2011 and have dried out both forest and grassland, providing ample fuel for wildfires. Relatively high winds and low humidity levels have also contributed to the rapid spread and expansion of fires. According to a Texas Forest Service (TXFS) Incident Management Situation Report dated Sept. 7, 2011, TXFS had responded to 172 fires affecting an area of 546.53 square kilometers (135,051 acres) over the preceding seven days. Fires near Bastrop, TX to the east of Austin had destroyed 785 homes as of Sept. 7, 2011.

Geospace Multiprobes

NASA Technical Reports Server (NTRS)

1997-01-01

The foregoing science discussions, the required measurements and the detailed implementation plans should provide ample evidence in support of the contention that geospace multiprobes are the next logical step forward in exploration of our environment. The advancement of technology in areas such as mechanical engineering, power systems, circuit miniaturization, high-capacity data storage, and innovative propulsion systems all allow the implementation of multiple satellite configurations within a constrained budget. The problems that have plagued our interpretation of previous data and the advancements that could not be made without the availability of multiple platforms can now be overcome. New multiprobe missions promise to produce a real leap forward in our understanding of the geospace environment for they will allow all the required measurements to be made in all the right places. The most efficient use of resources, and application of experience and knowledge, will be achieved from a series of missions such as envisioned by Solar Terrestrial Probes. The return for our investment in a multiprobe mission sequence is the organized advancement of our understanding in two key areas. First, we will understand the geospace environment to a level that will allow real quantitative assessment of the impacts of humans and the vulnerability of human space systems. Second, this advancement will allow us to more fully evaluate present and future data from other planetary environments to assess differences important to habitability.

Partial ASL extensions for stochastic programming.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gay, David

2010-03-31

partially completed extensions for stochastic programming to the AMPL/solver interface library (ASL).modeling and experimenting with stochastic recourse problems. This software is not primarily for military applications

Transcriptional reprogramming and stimulation of leaf respiration by elevated CO2 concentration is diminished, but not eliminated, under limiting nitrogen supply.

PubMed

Markelz, R J Cody; Lai, Lisa X; Vosseler, Lauren N; Leakey, Andrew D B

2014-04-01

Plant respiration responses to elevated CO2 concentration ( [CO2 ] ) have been studied for three decades without consensus about the mechanism of response. Positive effects of elevated [CO2 ] on leaf respiration have been attributed to greater substrate supply resulting from stimulated photosynthesis. Negative effects of elevated [CO2 ] on leaf respiration have been attributed to reduced demand for energy for protein turnover assumed to result from lower leaf N content. Arabidopsis thaliana was grown in ambient (370 ppm) and elevated (750 ppm) [CO2 ] with limiting and ample N availabilities. The stimulation of leaf dark respiration was attenuated in limiting N (+12%) compared with ample N supply (+30%). This response was associated with smaller stimulation of photosynthetic CO2 uptake, but not interactive effects of elevated CO2 and N supply on leaf protein, amino acids or specific leaf area. Elevated [CO2 ] also resulted in greater abundance of transcripts for many components of the respiratory pathway. A greater transcriptional response to elevated [CO2 ] was observed in ample N supply at midday versus midnight, consistent with reports that protein synthesis is greatest during the day. Greater foliar expression of respiratory genes under elevated [CO2 ] has now been observed in diverse herbaceous species, suggesting a widely conserved response. © 2013 John Wiley & Sons Ltd.

A case study of aerosol depletion in a biomass burning plume over Eastern Canada during the BORTAS field experiment

NASA Astrophysics Data System (ADS)

Franklin, Jonathan E.; Griffin, Debora; Pierce, Jeffrey R.; Drummond, James R.; Waugh, David; Palmer, Paul; Chisholm, Lucy; Duck, Thomas J.; Lesins, Glen; Walker, Kaley A.; Hopper, Jason T.; Curry, Kevin R.; Sakamoto, Kimiko M.; Dan, Lin; Kliever, Jenny; O'Neill, Norm

2013-04-01

Wild fires started by lightning are a significant source of carbonaceous aerosols and trace gases to the atmosphere. Careful observations of biomass burning plumes are required to quantify the long range transport and chemical evolution of the outflow from these fires. During the summer of 2011 an international effort - the Quantifying the impact of BOReal forest fires on Tropospheric oxidants over the Atlantic using Aircraft and Satellites (BORTAS) project - led by the University of Edinburgh, evaluated the chemistry and dynamics of Boreal biomass burning plumes through aircraft, satellite, and ground-based measurements. The Dalhousie Ground Station (DGS), located in Halifax, Nova Scotia, provided ground support to the BORTAS campaign. Two Fourier Transform Spectrometers (FTSs) provided solar absorption measurements of trace gases while two photometers provided aerosol optical depths. On 20 July 2011 a plume of elevated carbon monoxide and other trace gases was detected by the FTS instruments at the DGS; however, particulate data gathered from the co-located sun photometer and the Dalhousie Raman Lidar system showed no enhancement of fine-mode aerosol for the initial 7 hours of the event. After that time, particulates increased in abundance and a peak aerosol optical depth of 2.3 was measured on 21 July. FLEXPART trajectory analyses suggest that this plume originated in fires that were burning in Northwestern Ontario and Eastern Manitoba from 17 to 19 July. Despite the sparse observing network in the region, there is ample evidence of a significant lofting event via the same meso-scale convective system that tempered the burning on the 19th. We will provide an overview of this event and present evidence that precipitation scavenging was the most likely mechanism for the observed aerosol/trace gas anomaly. Support for this this research was provided by the Canadian Space Agency (CSA) and the Natural Sciences and Engineering Research Council of Canada.

Sexual counseling and cardiovascular disease: practical approaches

PubMed Central

Steinke, Elaine E; Jaarsma, Tiny

2015-01-01

Patients with cardiovascular disease and their partners expect health care providers to provide sexual counseling to assist them in maintaining sexual quality of life. Evidence suggests however, that there is a gap in integrating evidence into practice and that relatively few cardiac patients receive sexual counseling. This can result in negative psychological, physical, and quality of life outcomes for couples who may needlessly decide sexual activity is too risky and cease all sexual activity. Two scientific statements now exist that provide ample guidance to health care providers in discussing this important topic. Using a team approach that includes physicians, nurses, physical therapists, rehabilitation staff, and others is important to ensure that sexual counseling occurs throughout recovery. In addition, several trials using interventional approaches for sexual counseling provide insight into successful approaches for sexual counseling in practice. This article provides practical strategies and evidence-based approaches for assessment and sexual counseling for all cardiac patients and their partners, and specific counseling for those with ischemic conditions, heart failure, and implanted devices. PMID:25219908

Sexual counseling and cardiovascular disease: practical approaches.

PubMed

Steinke, Elaine E; Jaarsma, Tiny

2015-01-01

Patients with cardiovascular disease and their partners expect health care providers to provide sexual counseling to assist them in maintaining sexual quality of life. Evidence suggests however, that there is a gap in integrating evidence into practice and that relatively few cardiac patients receive sexual counseling. This can result in negative psychological, physical, and quality of life outcomes for couples who may needlessly decide sexual activity is too risky and cease all sexual activity. Two scientific statements now exist that provide ample guidance to health care providers in discussing this important topic. Using a team approach that includes physicians, nurses, physical therapists, rehabilitation staff, and others is important to ensure that sexual counseling occurs throughout recovery. In addition, several trials using interventional approaches for sexual counseling provide insight into successful approaches for sexual counseling in practice. This article provides practical strategies and evidence-based approaches for assessment and sexual counseling for all cardiac patients and their partners, and specific counseling for those with ischemic conditions, heart failure, and implanted devices.

Comparison of measured electron energy spectra for six matched, radiotherapy accelerators.

PubMed

McLaughlin, David J; Hogstrom, Kenneth R; Neck, Daniel W; Gibbons, John P

2018-05-01

This study compares energy spectra of the multiple electron beams of individual radiotherapy machines, as well as the sets of spectra across multiple matched machines. Also, energy spectrum metrics are compared with central-axis percent depth-dose (PDD) metrics. A lightweight, permanent magnet spectrometer was used to measure energy spectra for seven electron beams (7-20 MeV) on six matched Elekta Infinity accelerators with the MLCi2 treatment head. PDD measurements in the distal falloff region provided R 50 and R 80-20 metrics in Plastic Water ® , which correlated with energy spectrum metrics, peak mean energy (PME) and full-width at half maximum (FWHM). Visual inspection of energy spectra and their metrics showed whether beams on single machines were properly tuned, i.e., FWHM is expected to increase and peak height decrease monotonically with increased PME. Also, PME spacings are expected to be approximately equal for 7-13 MeV beams (0.5-cm R 90 spacing) and for 13-16 MeV beams (1.0-cm R 90 spacing). Most machines failed these expectations, presumably due to tolerances for initial beam matching (0.05 cm in R 90 ; 0.10 cm in R 80-20 ) and ongoing quality assurance (0.2 cm in R 50 ). Also, comparison of energy spectra or metrics for a single beam energy (six machines) showed outlying spectra. These variations in energy spectra provided ample data spread for correlating PME and FWHM with PDD metrics. Least-squares fits showed that R 50 and R 80-20 varied linearly and supralinearly with PME, respectively; however, both suggested a secondary dependence on FWHM. Hence, PME and FWHM could serve as surrogates for R 50 and R 80-20 for beam tuning by the accelerator engineer, possibly being more sensitive (e.g., 0.1 cm in R 80-20 corresponded to 2.0 MeV in FWHM). Results of this study suggest a lightweight, permanent magnet spectrometer could be a useful beam-tuning instrument for the accelerator engineer to (a) match electron beams prior to beam commissioning, (b) tune electron beams for the duration of their clinical use, and (c) provide estimates of PDD metrics following machine maintenance. However, a real-time version of the spectrometer is needed to be practical. © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

"Sometimes the naked taste of potato reminds me of being poor".

PubMed

Potter, Polyxeni

2009-06-01

"I want to paint men and women with that something of the eternal which the halo used to symbolize and which we seek to convey by the actual radiance and vibration of our coloring," wrote Vincent van Gogh in one of his celebrated letters. Hundreds of these were written mostly to his brother Theo, an art dealer in Paris who provided him with financial and emotional support throughout his brief but brilliant career. The letters lay out the artist's philosophy of life and reveal ample literary inclinations as well as spiritual depth. "Saying a thing well is as interesting and as difficult as painting it," he wrote.

Small-Grid Dithers for the JWST Coronagraphs

NASA Technical Reports Server (NTRS)

Lajoie, Charles-Philippe; Soummer, Remi; Pueyo, Laurent; Hines, Dean C.; Nelan, Edmund P.; Perrin, Marshall; Clampin, Mark; Isaacs, John C.

2016-01-01

We discuss new results of coronagraphic simulations demonstrating a novel mode for JWST that utilizes sub-pixel dithered reference images, called Small-Grid Dithers, to optimize coronagraphic PSF subtraction. These sub-pixel dithers are executed with the Fine Steering Mirror under fine guidance, are accurate to approx.2-3 milliarcseconds (1-s/axis), and provide ample speckle diversity to reconstruct an optimized synthetic reference PSF using LOCI or KLIP. We also discuss the performance gains of Small-Grid Dithers compared to the standard undithered scenario, and show potential contrast gain factors for the NIRCam and MIRI coronagraphs ranging from 2 to more than 10, respectively.

Proceedings of the International Symposium on Quantum Biology and Quantum Pharmacology (14th) Held in Marineland, Florida on March 12-14 1987. Annual Sanibel Symposia (27th). Part 1.

DTIC Science & Technology

1987-01-01

extension, though at a different rate. At the 6-31G** level, the C--O elon - gation in the three dimers is equal to 0.012 A and 0.014 A in the formic acid...will have vastly different counts of paths, even though they possess similar properties. An ex- ample is provided by civetone, a macrocyclic musk and a...sterol that possesses a de- cidedly musk -like odor as observed by Prelog and Ruicka [141. Both have a similar periphery and a similar musk odor, but

Minerva: A Dedicated Observatory for the Detection of Small Planets in the Solar Neighborhood

NASA Astrophysics Data System (ADS)

Hogstrom, Kristina; Johnson, J. A.; Wright, J.; McCrady, N.; Swift, J.; Muirhead, P.; Bottom, M.; Plavchan, P.; Zhao, M.; Riddle, R. L.

2013-01-01

Minerva is an array of 0.7m aperture robotic telescopes to be built atop Palomar Mountain outfitted for both photometry and high-resolution spectroscopy. It will be the first U.S. observatory dedicated to exoplanetary science capable of both precise radial velocimetry and transit studies. The multi-telescope concept will be implemented to either observe separate targets or a single target with a larger effective aperture. The flexibility of the observatory will maximize scientific potential and also provide ample opportunities for education and public outreach. The design and implementation of Minerva will be carried out by postdoctoral and student researchers at Caltech.

RESIDUAL RISK ASSESSMENT: ETHYLENE OXIDE ...

EPA Pesticide Factsheets

This document describes the residual risk assessment for the Ethylene Oxide Commercial Sterilization source category. For stationary sources, section 112 (f) of the Clean Air Act requires EPA to assess risks to human health and the environment following implementation of technology-based control standards. If these technology-based control standards do not provide an ample margin of safety, then EPA is required to promulgate addtional standards. This document describes the methodology and results of the residual risk assessment performed for the Ethylene Oxide Commercial Sterilization source category. The results of this analyiss will assist EPA in determining whether a residual risk rule for this source category is appropriate.

Medically Inappropriate or Futile Treatment: Deliberation and Justification 1

PubMed Central

Misak, Cheryl J.; White, Douglas B.; Truog, Robert D.

2016-01-01

This paper reframes the futility debate, moving away from the question “Who decides when to end what is considered to be a medically inappropriate or futile treatment?” and toward the question “How can society make policy that will best account for the multitude of values and conflicts involved in such decision-making?” It offers a pragmatist moral epistemology that provides us with (1) a clear justification of why it is important to take best standards, norms, and physician judgment seriously and (2) a clear justification of why ample opportunity must be made for patients, families, and society to challenge those standards and norms. PMID:26681796

Role of Hydrophobic Clusters and Long-Range Contact Networks in the Folding of (α/β)8 Barrel Proteins

PubMed Central

Selvaraj, S.; Gromiha, M. Michael

2003-01-01

Analysis on the three dimensional structures of (α/β)8 barrel proteins provides ample light to understand the factors that are responsible for directing and maintaining their common fold. In this work, the hydrophobically enriched clusters are identified in 92% of the considered (α/β)8 barrel proteins. The residue segments with hydrophobic clusters have high thermal stability. Further, these clusters are formed and stabilized through long-range interactions. Specifically, a network of long-range contacts connects adjacent β-strands of the (α/β)8 barrel domain and the hydrophobic clusters. The implications of hydrophobic clusters and long-range networks in providing a feasible common mechanism for the folding of (α/β)8 barrel proteins are proposed. PMID:12609894

Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis

PubMed Central

Hohwieler, Meike; Perkhofer, Lukas; Liebau, Stefan; Seufferlein, Thomas; Müller, Martin

2016-01-01

Cystic fibrosis (CF) is one of the most frequently occurring inherited human diseases caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which lead to ample defects in anion transport and epithelial fluid secretion. Existing models lack both access to early stages of CF development and a coeval focus on the gastrointestinal CF phenotypes, which become increasingly important due increased life span of the affected individuals. Here, we provide a comprehensive overview of gastrointestinal facets of CF and the opportunity to model these in various systems in an attempt to understand and treat CF. A particular focus is given on forward-leading organoid cultures, which may circumvent current limitations of existing models and thereby provide a platform for drug testing and understanding of disease pathophysiology in gastrointestinal organs. PMID:28815024

Pharmacy professionalism and the digital age.

PubMed

Rutter, Paul M; Duncan, Gregory

2011-12-01

To explore how the use of digital media could affect how people view professional behaviour. The growth in social networking sites has been phenomenal and they are now an extremely popular medium for interacting with others both commercially and privately. This as-yet-uncontrolled digital media provides ample opportunities for public and professional scrutiny for the unwary. Instances of employer screening and employee dismissal are already documented. All pharmacists who use digital media now need to be conscious that their virtual presence could be subject to regulator investigation. It is important that individuals are aware of the risks associated with using digital media and that pharmacy organisations begin to provide clear leadership to help pharmacists know what is and is not acceptable. © 2011 The Authors. IJPP © 2011 Royal Pharmaceutical Society.

Writing a review article - Are you making these mistakes?

PubMed

Daldrup-Link, Heike E

2018-01-01

An explosion of scientific publications over the last decades has increased the need for review articles: Carefully crafted scientific review articles can provide the novice reader with an overview of a new subject and provide the expert with a synthesis of scientific evidence, proof of reproducibility of published data and pooled estimates of common truth through meta-analyses. Unfortunately, while there are ample presentations and published guidelines for the preparation of scientific articles available, detailed information about how to properly prepare scientific review articles is relatively scarce. This perspective summarizes possible mistakes that can lead to misinformation in scientific review articles with the goal to help authors to improve the scientific contribution of their review article and thereby, increase the respective value of these articles for the scientific community.

9 CFR 3.126 - Facilities, indoor.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., vents, fans, or air-conditioning and shall be ventilated so as to minimize drafts, odors, and moisture condensation. (c) Lighting. Indoor housing facilities shall have ample lighting, by natural or artificial means...

9 CFR 354.226 - Lighting and ventilation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Buildings and Plant Facilities § 354.226 Lighting and ventilation. There shall be ample light, either natural or artificial or...

Spitzer Space Telescope proposal process

NASA Astrophysics Data System (ADS)

Laine, S.; Silbermann, N. A.; Rebull, L. M.; Storrie-Lombardi, L. J.

2006-06-01

This paper discusses the Spitzer Space Telescope General Observer proposal process. Proposals, consisting of the scientific justification, basic contact information for the observer, and observation requests, are submitted electronically using a client-server Java package called Spot. The Spitzer Science Center (SSC) uses a one-phase proposal submission process, meaning that fully-planned observations are submitted for most proposals at the time of submission, not months after acceptance. Ample documentation and tools are available to the observers on SSC web pages to support the preparation of proposals, including an email-based Helpdesk. Upon submission proposals are immediately ingested into a database which can be queried at the SSC for program information, statistics, etc. at any time. Large proposals are checked for technical feasibility and all proposals are checked against duplicates of already approved observations. Output from these tasks is made available to the Time Allocation Committee (TAC) members. At the review meeting, web-based software is used to record reviewer comments and keep track of the voted scores. After the meeting, another Java-based web tool, Griffin, is used to track the approved programs as they go through technical reviews, duplication checks and minor modifications before the observations are released for scheduling. In addition to detailing the proposal process, lessons learned from the first two General Observer proposal calls are discussed.

Cuckoos, cowbirds and hosts: adaptations, trade-offs and constraints.

PubMed

Krüger, Oliver

2007-10-29

The interactions between brood parasitic birds and their host species provide one of the best model systems for coevolution. Despite being intensively studied, the parasite-host system provides ample opportunities to test new predictions from both coevolutionary theory as well as life-history theory in general. I identify four main areas that might be especially fruitful: cuckoo female gentes as alternative reproductive strategies, non-random and nonlinear risks of brood parasitism for host individuals, host parental quality and targeted brood parasitism, and differences and similarities between predation risk and parasitism risk. Rather than being a rare and intriguing system to study coevolutionary processes, I believe that avian brood parasites and their hosts are much more important as extreme cases in the evolution of life-history strategies. They provide unique examples of trade-offs and situations where constraints are either completely removed or particularly severe.

Ion transport through lipid bilayers by synthetic ionophores: modulation of activity and selectivity.

PubMed

De Riccardis, Francesco; Izzo, Irene; Montesarchio, Daniela; Tecilla, Paolo

2013-12-17

The ion-coupled processes that occur in the plasma membrane regulate the cell machineries in all the living organisms. The details of the chemical events that allow ion transport in biological systems remain elusive. However, investigations of the structure and function of natural and artificial transporters has led to increasing insights about the conductance mechanisms. Since the publication of the first successful artificial system by Tabushi and co-workers in 1982, synthetic chemists have designed and constructed a variety of chemically diverse and effective low molecular weight ionophores. Despite their relative structural simplicity, ionophores must satisfy several requirements. They must partition in the membrane, interact specifically with ions, shield them from the hydrocarbon core of the phospholipid bilayer, and transport ions from one side of the membrane to the other. All these attributes require amphipathic molecules in which the polar donor set used for ion recognition (usually oxygens for cations and hydrogen bond donors for anions) is arranged on a lipophilic organic scaffold. Playing with these two structural motifs, donor atoms and scaffolds, researchers have constructed a variety of different ionophores, and we describe a subset of interesting examples in this Account. Despite the ample structural diversity, structure/activity relationships studies reveal common features. Even when they include different hydrophilic moieties (oxyethylene chains, free hydroxyl, etc.) and scaffolds (steroid derivatives, neutral or polar macrocycles, etc.), amphipathic molecules, that cannot span the entire phospholipid bilayer, generate defects in the contact zone between the ionophore and the lipids and increase the permeability in the bulk membrane. Therefore, topologically complex structures that span the entire membrane are needed to elicit channel-like and ion selective behaviors. In particular the alternate-calix[4]arene macrocycle proved to be a versatile platform to obtain 3D-structures that can form unimolecular channels in membranes. In these systems, the selection of proper donor groups allows us to control the ion selectivity of the process. We can switch from cation to anion transport by substituting protonated amines for the oxygen donors. Large and stable tubular structures with nanometric sized transmembrane nanopores that provide ample internal space represent a different approach for the preparation of synthetic ion channels. We used the metal-mediated self-assembly of porphyrin ligands with Re(I) corners as a new method for producing to robust channel-like structures. Such structures can survive in the complex membrane environment and show interesting ionophoric behavior. In addition to the development of new design principles, the selective modification of the biological membrane permeability could lead to important developments in medicine and technology.

Design and Construction of an Inexpensive Homemade Plant Growth Chamber

PubMed Central

Katagiri, Fumiaki; Canelon-Suarez, Dario; Griffin, Kelsey; Petersen, John; Meyer, Rachel K.; Siegle, Megan; Mase, Keisuke

2015-01-01

Plant growth chambers produce controlled environments, which are crucial in making reproducible observations in experimental plant biology research. Commercial plant growth chambers can provide precise controls of environmental parameters, such as temperature, humidity, and light cycle, and the capability via complex programming to regulate these environmental parameters. But they are expensive. The high cost of maintaining a controlled growth environment is often a limiting factor when determining experiment size and feasibility. To overcome the limitation of commercial growth chambers, we designed and constructed an inexpensive plant growth chamber with consumer products for a material cost of $2,300. For a comparable growth space, a commercial plant growth chamber could cost $40,000 or more. Our plant growth chamber had outside dimensions of 1.5 m (W) x 1.8 m (D) x 2 m (H), providing a total growth area of 4.5 m2 with 40-cm high clearance. The dimensions of the growth area and height can be flexibly changed. Fluorescent lights with large reflectors provided a relatively spatially uniform photosynthetically active radiation intensity of 140–250 μmoles/m2/sec. A portable air conditioner provided an ample cooling capacity, and a cooling water mister acted as a powerful humidifier. Temperature, relative humidity, and light cycle inside the chamber were controlled via a z-wave home automation system, which allowed the environmental parameters to be monitored and programmed through the internet. In our setting, the temperature was tightly controlled: 22.2°C±0.8°C. The one-hour average relative humidity was maintained at 75%±7% with short spikes up to ±15%. Using the interaction between Arabidopsis and one of its bacterial pathogens as a test experimental system, we demonstrate that experimental results produced in our chamber were highly comparable to those obtained in a commercial growth chamber. In summary, our design of an inexpensive plant growth chamber will tremendously increase research opportunities in experimental plant biology. PMID:25965420

Design and construction of an inexpensive homemade plant growth chamber.

PubMed

Katagiri, Fumiaki; Canelon-Suarez, Dario; Griffin, Kelsey; Petersen, John; Meyer, Rachel K; Siegle, Megan; Mase, Keisuke

2015-01-01

Plant growth chambers produce controlled environments, which are crucial in making reproducible observations in experimental plant biology research. Commercial plant growth chambers can provide precise controls of environmental parameters, such as temperature, humidity, and light cycle, and the capability via complex programming to regulate these environmental parameters. But they are expensive. The high cost of maintaining a controlled growth environment is often a limiting factor when determining experiment size and feasibility. To overcome the limitation of commercial growth chambers, we designed and constructed an inexpensive plant growth chamber with consumer products for a material cost of $2,300. For a comparable growth space, a commercial plant growth chamber could cost $40,000 or more. Our plant growth chamber had outside dimensions of 1.5 m (W) x 1.8 m (D) x 2 m (H), providing a total growth area of 4.5 m2 with 40-cm high clearance. The dimensions of the growth area and height can be flexibly changed. Fluorescent lights with large reflectors provided a relatively spatially uniform photosynthetically active radiation intensity of 140-250 μmoles/m2/sec. A portable air conditioner provided an ample cooling capacity, and a cooling water mister acted as a powerful humidifier. Temperature, relative humidity, and light cycle inside the chamber were controlled via a z-wave home automation system, which allowed the environmental parameters to be monitored and programmed through the internet. In our setting, the temperature was tightly controlled: 22.2°C±0.8°C. The one-hour average relative humidity was maintained at 75%±7% with short spikes up to ±15%. Using the interaction between Arabidopsis and one of its bacterial pathogens as a test experimental system, we demonstrate that experimental results produced in our chamber were highly comparable to those obtained in a commercial growth chamber. In summary, our design of an inexpensive plant growth chamber will tremendously increase research opportunities in experimental plant biology.

Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.

PubMed

Khan, Sameena; Sharma, Arvind; Belrhali, Hassan; Yogavel, Manickam; Sharma, Amit

2014-06-01

Malaria parasites inevitably develop drug resistance to anti-malarials over time. Hence the immediacy for discovering new chemical scaffolds to include in combination malaria drug therapy. The desirable attributes of new chemotherapeutic agents currently include activity against both liver and blood stage malaria parasites. One such recently discovered compound called cladosporin abrogates parasite growth via inhibition of Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), an enzyme central to protein translation. Here, we present crystal structure of ternary PfKRS-lysine-cladosporin (PfKRS-K-C) complex that reveals cladosporin's remarkable ability to mimic the natural substrate adenosine and thereby colonize PfKRS active site. The isocoumarin fragment of cladosporin sandwiches between critical adenine-recognizing residues while its pyran ring fits snugly in the ribose-recognizing cavity. PfKRS-K-C structure highlights ample space within PfKRS active site for further chemical derivatization of cladosporin. Such derivatives may be useful against additional human pathogens that retain high conservation in cladosporin chelating residues within their lysyl-tRNA synthetase.

VIII. THE PAST, PRESENT, AND FUTURE OF DEVELOPMENTAL METHODOLOGY.

PubMed

Little, Todd D; Wang, Eugene W; Gorrall, Britt K

2017-06-01

This chapter selectively reviews the evolution of quantitative practices in the field of developmental methodology. The chapter begins with an overview of the past in developmental methodology, discussing the implementation and dissemination of latent variable modeling and, in particular, longitudinal structural equation modeling. It then turns to the present state of developmental methodology, highlighting current methodological advances in the field. Additionally, this section summarizes ample quantitative resources, ranging from key quantitative methods journal articles to the various quantitative methods training programs and institutes. The chapter concludes with the future of developmental methodology and puts forth seven future innovations in the field. The innovations discussed span the topics of measurement, modeling, temporal design, and planned missing data designs. Lastly, the chapter closes with a brief overview of advanced modeling techniques such as continuous time models, state space models, and the application of Bayesian estimation in the field of developmental methodology. © 2017 The Society for Research in Child Development, Inc.

TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground.

PubMed

Beck, Inken M; Sedlacek, Radislav

2015-02-01

The 12th Transgenic Technology meeting was held in Edinburgh on 6th-8th October 2014 and interest to participate in the meeting overcame all expectations. The TT2014 was the largest meeting ever with more than 540 scientists, technicians, and students from all over the world. The meeting had an excellent scientific program that brought information on the latest ground-breaking technologies for gene targeting and genome editing using programmable nucleases into the foreground. These presentations were well balanced with several highlights over viewing topics in embryonic stem cell research, embryogenesis, disease models, and animals in agriculture. Ample space was reserved also for short talks presenting technical development and for highlighting posters contributions. A highlight of the meeting was the award of the 10th International Society of Transgenic Technologies Prize to Janet Rossant for her outstanding contributions in the field of mouse embryogenesis.

Integral Radiator and Storage Tank

NASA Technical Reports Server (NTRS)

Burke, Kenneth A.; Miller, John R.; Jakupca, Ian; Sargi,Scott

2007-01-01

A simplified, lightweight system for dissipating heat of a regenerative fuel- cell system would include a heat pipe with its evaporator end placed at the heat source and its condenser end integrated into the wall of the regenerative fuel cell system gas-storage tanks. The tank walls act as heat-radiating surfaces for cooling the regenerative fuel cell system. The system was conceived for use in outer space, where radiation is the only physical mechanism available for transferring heat to the environment. The system could also be adapted for use on propellant tanks or other large-surface-area structures to convert them to space heat-radiating structures. Typically for a regenerative fuel cell system, the radiator is separate from the gas-storage tanks. By using each tank s surface as a heat-radiating surface, the need for a separate, potentially massive radiator structure is eliminated. In addition to the mass savings, overall volume is reduced because a more compact packaging scheme is possible. The underlying tank wall structure provides ample support for heat pipes that help to distribute the heat over the entire tank surface. The heat pipes are attached to the outer surface of each gas-storage tank by use of a high-thermal conductance, carbon-fiber composite-material wrap. Through proper choice of the composite layup, it is possible to exploit the high longitudinal conductivity of the carbon fibers (greater than the thermal conductivity of copper) to minimize the unevenness of the temperature distribution over the tank surface, thereby helping to maximize the overall heat-transfer efficiency. In a prototype of the system, the heat pipe and the composite wrap contribute an average mass of 340 g/sq m of radiator area. Lightweight space radiator panels have a mass of about 3,000 g/sq m of radiator area, so this technique saves almost 90 percent of the mass of separate radiator panels. In tests, the modified surface of the tank was found to have an emissivity of 0.85. The composite wrap remained tightly bound to the surface of the tank throughout the testing in thermal vacuum conditions.

Photosynthetic capacity and dry mass partitioning in dwarf and semi-dwarf wheat (Triticum aestivum L.)

NASA Technical Reports Server (NTRS)

Bishop, D. L.; Bugbee, B. G.

1998-01-01

Efficient use of space and high yields are critical for long-term food production aboard the International Space Station. The selection of a full dwarf wheat (less than 30 cm tall) with high photosynthetic and yield potential is a necessary prerequisite for growing wheat in the controlled, volume-limited environments available aboard long-term spaceflight missions. This study evaluated the photosynthetic capacity and carbon partitioning of a full-dwarf wheat cultivar, Super Dwarf, which is routinely used in spaceflight studies aboard U.S. space shuttle and NASA/Mir missions and made comparisons with other dwarf and semi-dwarf wheat cultivars utilized in other ground-based studies in plant space biology. Photosynthetic capacity of the flag leaf in two dwarf (Super Dwarf, BB-19), and three semi-dwarf (Veery-10, Yecora Rojo, IBWSN 199) wheat cultivars (Triticum aestivum L.) was assessed by measuring: net maximum photosynthetic rate, RuBP carboxylation efficiency, chlorophyll concentration and flag leaf area. Dry mass partitioning of carbohydrates to the leaves, sheaths, stems and ear was also assessed. Plants were grown under controlled environmental conditions in three replicate studies: slightly enriched CO2 (370 micromoles mol-1), high photosynthetic photon flux (1000 micromoles m-2 s-1; 58 mol m-2 d-1) for a 16 h photoperiod, 22/15 degrees C day/night temperatures, ample nutrients and water provided by one-half strength Hoagland's nutrient solution (Hoagland and Arnon, 1950). Photosynthetic capacity of the flag leaf was determined at anthesis using net CO2 exchange rate versus internal CO2 concentration curves measured under saturating light (2000 micromoles m-2 s-1) and CO2 (1000 micromoles mol-1). Dwarf wheat cultivars had greater photosynthetic capacities than the taller semi-dwarfs, they averaged 20% higher maximum net photosynthetic rates compared to the taller semi-dwarfs, but these higher rates occurred only at anthesis, had slightly greater carboxylation efficiencies and significantly increased chlorophyll concentrations per unit leaf area. The reduced-height wheat had significantly less dry mass fraction in the stem but greater dry mass partitioned to the ear than the taller semi-dwarfs (Yecora rojo, IBWSN-199). Studies with detached heads confirm that the head is a significant sink in the shorter wheat cultivars.

30 CFR 77.1605 - Loading and haulage equipment; installations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... passage of wheels. (h) Rocker-bottom or bottom-dump cars shall be equipped with positive locking devices, or other suitable devices. (i) Ramps and dumps shall be of solid construction, of ample width, have...

Convectively Induced Turbulence Encountered During NASA's Fall-2000 Flight Experiments

NASA Technical Reports Server (NTRS)

Hamilton, David W.; Proctor, Fred H.

2002-01-01

Aircraft encounters with atmospheric turbulence are a leading cause of in-flight injuries aboard commercial airliners and cost the airlines millions of dollars each year. Most of these injuries are due to encounters with turbulence in and around convection. In a recent study of 44 turbulence accident reports between 1990 and 1996, 82% of the cases were found to be near or within convective activity (Kaplan et al. 1999). According to NTSB accident reports, pilots' descriptions of these turbulence encounters include 'abrupt', 'in Instrument Meteorological Conditions (IMC)', 'saw nothing on the weather radar', and 'the encounter occurred while deviating around' convective activity. Though the FAA has provided guidelines for aircraft operating in convective environments, turbulence detection capability could decrease the number of injuries by alerting pilots of a potential encounter. The National Aeronautics and Space Administration, through its Aviation Safety Program, is addressing turbulence hazards through research, flight experiments, and data analysis. Primary focus of this program element is the characterization of turbulence and its environment, as well as the development and testing of hazard estimation algorithms for both radar and in situ detection. The ultimate goal is to operationally test sensors that will provide ample warning prior to hazardous turbulence encounters. In order to collect data for support of these activities, NASA-Langley's B-757 research aircraft was directed into regions favorable for convectively induced turbulence (CIT). On these flights, the airborne predictive wind shear (PWS) radar, augmented with algorithms designed for turbulence detection, was operated in real time to test this capability. In this paper, we present the results of two research flights when turbulence was encountered. Described is an overview of the flights, the general radar performance, and details of four encounters with severe turbulence.

Expert consensus-building for developing guidelines: lessons learned from a dengue economics workshop.

PubMed

Constenla, Dagna; Lefcourt, Noah; Garcia, Cristina

2013-09-01

A workshop with 20 experts of diverse backgrounds from five countries in the Americas was convened for two-and-a-half days in March 2012 to discuss and develop a standardized methodology for assessing the economic cost of dengue. This article discusses a number of factors that contributed to the workshop's success, including: engaging the experts at various stages of the process; convening a multidisciplinary group to reduce expert bias and provide a more comprehensive and integrated approach; facilitating guided small- and large-group discussions; developing effective cross-cultural collectivism, trust, communication, and empathy across the expert panel; establishing clear lines of responsibilities within each group of experts; breaking down the complex issues into smaller and simpler ideas; providing ample background materials in multiple languages prior to the workshop. Challenges and areas for improvement are also covered.

In Search of the Physics: The Interplay of Experiment and Computation in Slat Aeroacoustics

NASA Technical Reports Server (NTRS)

Khorrami, Mehdi R.; Choudhari, Meelan; Singer, Bart A.; Lockard, David P.; Streett, Craig L.

2003-01-01

The synergistic use of experiments and numerical simulations can uncover the underlying physics of airframe noise sources. We focus on the high-lift noise component associated with a leading-edge slat; flap side-edge noise is discussed in a companion paper by Streett et al. (2003). The present paper provides an overview of how slat noise was split into subcomponents and analyzed with carefully planned complementary experimental and numerical tests. We consider both tonal and broadband aspects of slat noise. The predicted far-field noise spectra are shown to be in good qualitative (and, to lesser extent, good quantitative agreement) with acoustic array measurements. Although some questions remain unanswered, the success of current airframe noise studies provides ample promise that remaining technical issues can be successfully addressed in the near future.

Engineering approximations in welding: Bridging the gap between the speculation and simulation

DOE PAGES

Robino, Charles V.

2016-01-15

During the course of their careers, welding engineers and welding metallurgists are often confronted with questions regarding welding process and properties that on the surface appear to be simple and direct, but are in fact quite challenging. These questions generally mask an underlying complexity whose underpinnings in scientific and applied research predate even the founding of the American Welding Society, and previous Comfort A. Adams lectures provide ample and fascinating evidence of the breadth and depth of this complexity. Using these studies or their own experiences and investigations as a basis, most welding and materials engineers have developed engineering toolsmore » to provide working approaches to these day-to-day questions and problems. In this article several examples of research into developing working approaches to welding problems are presented.« less

Engineering approximations in welding: Bridging the gap between the speculation and simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robino, Charles V.

During the course of their careers, welding engineers and welding metallurgists are often confronted with questions regarding welding process and properties that on the surface appear to be simple and direct, but are in fact quite challenging. These questions generally mask an underlying complexity whose underpinnings in scientific and applied research predate even the founding of the American Welding Society, and previous Comfort A. Adams lectures provide ample and fascinating evidence of the breadth and depth of this complexity. Using these studies or their own experiences and investigations as a basis, most welding and materials engineers have developed engineering toolsmore » to provide working approaches to these day-to-day questions and problems. In this article several examples of research into developing working approaches to welding problems are presented.« less

A RAPIDLY EVOLVING REGION IN THE GALACTIC CENTER: WHY S-STARS THERMALIZE AND MORE MASSIVE STARS ARE MISSING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Xian; Amaro-Seoane, Pau, E-mail: Xian.Chen@aei.mpg.de, E-mail: Pau.Amaro-Seoane@aei.mpg.de

2014-05-10

The existence of ''S-stars'' within a distance of 1'' from Sgr A* contradicts our understanding of star formation, due to Sgr A* 's forbiddingly violent environment. A suggested possibility is that they form far away and were brought in by some fast dynamical process, since they are young. Nonetheless, all conjectured mechanisms either fail to reproduce their eccentricities—without violating their young age—or cannot explain the problem of {sup i}nverse mass segregation{sup :} the fact that lighter stars (the S-stars) are closer to Sgr A* and more massive ones, Wolf-Rayet (WR) and O-stars, are farther out. In this Letter we proposemore » that the mechanism responsible for both the distribution of the eccentricities and the paucity of massive stars is the Kozai-Lidov-like resonance induced by a sub-parsec disk recently discovered in the Galactic center. Considering that the disk probably extended to a smaller radius in the past, we show that in as short as (a few) 10{sup 6} yr, the stars populating the innermost 1'' region would redistribute in angular-momentum space and recover the observed ''super-thermal'' distribution. Meanwhile, WR and O-stars in the same region intermittently attain ample eccentricities that will lead to their tidal disruptions by the central massive black hole. Our results provide new evidences that Sgr A* was powered several millions years ago by an accretion disk as well as by tidal stellar disruptions.« less

Diarrheal illness among US residents providing medical services in Haiti during the cholera epidemic, 2010 to 2011.

PubMed

Schilling, Katharine A; Cartwright, Emily J; Stamper, John; Locke, Michael; Esposito, Douglas H; Balaban, Victor; Mintz, Eric

2014-01-01

Although nosocomial transmission of cholera is rare, two US healthcare workers (HCW) became ill with cholera after providing medical services during the Haiti cholera epidemic. To assess the incidence of diarrheal illness and explore preventive health behaviors practiced by US residents who provided medical services in Haiti, we conducted a cross-sectional, anonymous, web-based survey. We e-mailed 896 participants from 50 US-based, health-focused non-governmental organizations (NGOs), of whom 381 (43%) completed the survey. Fifty-six percent of respondents (n = 215) reported providing some care for patients with cholera. Diarrhea was reported by 31 (8%) respondents. One person was diagnosed with cholera by serologic testing. NGOs responding to international emergencies should ensure ample access to basic hygiene supplies and should promote their use to reduce the incidence of diarrheal illness among HCW working overseas. Published 2013.This article is a U.S.Government work and is in the public domain in the USA.

Towards a manufacturing ecosystem for integrated photonic sensors (Conference Presentation)

NASA Astrophysics Data System (ADS)

Miller, Benjamin L.

2017-03-01

Laboratory-scale demonstrations of optical biosensing employing structures compatible with CMOS fabrication, including waveguides, Mach-Zehnder interferometers, ring resonators, and photonic crystals, have provided ample validation of the promise of these technologies. However, to date there are relatively few examples of integrated photonic biosensors in the commercial sphere. The lack of successful translation from the laboratory to the marketplace is due in part to a lack of robust manufacturing processes for integrated photonics overall. This talk will describe efforts within the American Institute for Manufacturing Photonics (AIM Photonics), a public-private consortium funded by the Department of Defense, State governments, Universities, and Corporate partners to accelerate manufacturing of integrated photonic sensors.

[Rehabilitation and nursing-care robots].

PubMed

Hachisuka, Kenji

2016-04-01

In the extremely aged society, rehabilitation staff will be required to provide ample rehabilitation training for more stroke patients and more aged people with disabilities despite limitations in human resources. A nursing-care robot is one potential solution from the standpoint of rehabilitation. The nursing-care robot is defined as a robot which assists aged people and persons with disabilities in daily life and social life activities. The nursing-care robot consists of an independent support robot, caregiver support robot, and life support robot. Although many nursing-care robots have been developed, the most appropriate robot must be selected according to its features and the needs of patients and caregivers in the field of nursing-care.

Multi-service terminal adapter based on IP technology applications in rural area

NASA Astrophysics Data System (ADS)

Gao, Li; Li, Xiaobo; Yan, Juntao; Ren, Xupeng

Take advantage of ample modern existing telecom network resources to rural areas may achieve it's information society gradually. This includes the establishment of integrated rural information service platform, modern remote education center and electronic administration management platform for rural areas. The geographical and economic constraints must be overcome for structuring the rural service support system, in order to provide technical support, information products and information services to modern rural information service system. It is important that development an access platform based IP technology, which supports multi-service access in order to implement a variety of types of mobile terminal equipment adapter access and to reduce restrictions on mobile terminal equipment.

Ancient flood records from historical documents in Korea

NASA Astrophysics Data System (ADS)

Kim, H. J.; Noh, S. J.; Jang, C. H.

2009-04-01

This paper is designed to comprehensively study a myriad of floods that have been witnessed on the Korean Peninsula for the past two millennia, by reviewing historical documents. The floods between the era of Three Kingdoms and the age of the Choson Dynasty were listed in the Chronicles of Three Kingdoms on the Korean Peninsula, the History of the Goreyo Dynasty, and the Annals of the Choson Dynasty and the Encyclopedic Annals of the Korean History & Culture (Dongguk Munheon Bigo). In particular, the Annals of the Choson Dynasty provided an ample store of flood records. Based on the data, Korea is judged to have continuously experienced nationwide floods in the 17th century.

Reflections: Volunteering at Home.

PubMed

Hu, Amanda

2016-08-01

Many young people look forward to volunteering abroad and overlook the ample volunteer opportunities at home. There are several advantages to volunteering at home: you help people in your own community; you can make a long-term commitment; and you have continuity of care for your patients. There are >1200 free clinics in the United States whose main goal is to provide care to the indigent population. These free clinics are always looking for volunteers with specialized medical training. This article reviews the medically related and unrelated volunteer opportunities available in the United States. Volunteering at home is a worthwhile experience, and I encourage the otolaryngology community to explore these opportunities. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis

PubMed Central

2016-01-01

Surface- and tip-enhanced Raman spectroscopy (SERS and TERS) techniques exhibit highly localized chemical sensitivity, making them ideal for studying chemical reactions, including processes at catalytic surfaces. Catalyst structures, adsorbates, and reaction intermediates can be observed in low quantities at hot spots where electromagnetic fields are the strongest, providing ample opportunities to elucidate reaction mechanisms. Moreover, under ideal measurement conditions, it can even be used to trigger chemical reactions. However, factors such as substrate instability and insufficient signal enhancement still limit the applicability of SERS and TERS in the field of catalysis. By the use of sophisticated colloidal synthesis methods and advanced techniques, such as shell-isolated nanoparticle-enhanced Raman spectroscopy, these challenges could be overcome. PMID:27075515

U-Th-Pb, Sm-Nd, Rb-Sr, and Lu-Hf systematics of returned Mars samples

NASA Technical Reports Server (NTRS)

Tatsumoto, M.; Premo, W. R.

1988-01-01

The advantage of studying returned planetary samples cannot be overstated. A wider range of analytical techniques with higher sensitivities and accuracies can be applied to returned samples. Measurement of U-Th-Pb, Sm-Nd, Rb-Sr, and Lu-Hf isotopic systematics for chronology and isotopic tracer studies of planetary specimens cannot be done in situ with desirable precision. Returned Mars samples will be examined using all the physical, chemical, and geologic methods necessary to gain information on the origin and evolution of Mars. A returned Martian sample would provide ample information regarding the accretionary and evolutionary history of the Martian planetary body and possibly other planets of our solar system.

Core-Shell Co/CoO Integrated on 3D Nitrogen Doped Reduced Graphene Oxide Aerogel as an Enhanced Electrocatalyst for the Oxygen Reduction Reaction

PubMed Central

Wang, Meng; Hou, Yuyang; Slade, Robert C. T.; Wang, Jiazhao; Shi, Dongqi; Wexler, David; Liu, Huakun; Chen, Jun

2016-01-01

Here, we demonstrate that Cobalt/cobalt oxide core-shell nanoparticles integrated on nitrogen-doped (N-doped) three-dimensional reduced graphene oxide aerogel-based architecture (Co/CoO-NGA) were synthesized through a facile hydrothermal method followed by annealing treatment. The unique endurable porous structure could provide sufficient mass transfer channels and ample active sites on Co/CoO-NGA to facilitate the catalytic reaction. The synthesized Co/CoO-NGA was explored as an electrocatalyst for the oxygen reduction reaction, showing comparable oxygen reduction performance with excellent methanol resistance and better durability compared with Pt/C. PMID:27597939

A Unified Mathematical Framework for Coding Time, Space, and Sequences in the Hippocampal Region

PubMed Central

MacDonald, Christopher J.; Tiganj, Zoran; Shankar, Karthik H.; Du, Qian; Hasselmo, Michael E.; Eichenbaum, Howard

2014-01-01

The medial temporal lobe (MTL) is believed to support episodic memory, vivid recollection of a specific event situated in a particular place at a particular time. There is ample neurophysiological evidence that the MTL computes location in allocentric space and more recent evidence that the MTL also codes for time. Space and time represent a similar computational challenge; both are variables that cannot be simply calculated from the immediately available sensory information. We introduce a simple mathematical framework that computes functions of both spatial location and time as special cases of a more general computation. In this framework, experience unfolding in time is encoded via a set of leaky integrators. These leaky integrators encode the Laplace transform of their input. The information contained in the transform can be recovered using an approximation to the inverse Laplace transform. In the temporal domain, the resulting representation reconstructs the temporal history. By integrating movements, the equations give rise to a representation of the path taken to arrive at the present location. By modulating the transform with information about allocentric velocity, the equations code for position of a landmark. Simulated cells show a close correspondence to neurons observed in various regions for all three cases. In the temporal domain, novel secondary analyses of hippocampal time cells verified several qualitative predictions of the model. An integrated representation of spatiotemporal context can be computed by taking conjunctions of these elemental inputs, leading to a correspondence with conjunctive neural representations observed in dorsal CA1. PMID:24672015

Blue ocean strategy.

PubMed

Kim, W Chan; Mauborgne, Renée

2004-10-01

Despite a long-term decline in the circus industry, Cirque du Soleil profitably increased revenue 22-fold over the last ten years by reinventing the circus. Rather than competing within the confines of the existing industry or trying to steal customers from rivals, Cirque developed uncontested market space that made the competition irrelevant. Cirque created what the authors call a blue ocean, a previously unknown market space. In blue oceans, demand is created rather than fought over. There is ample opportunity for growth that is both profitable and rapid. In red oceans--that is, in all the industries already existing--companies compete by grabbing for a greater share of limited demand. As the market space gets more crowded, prospects for profits and growth decline. Products turn into commodities, and increasing competition turns the water bloody. There are two ways to create blue oceans. One is to launch completely new industries, as eBay did with online auctions. But it's much more common for a blue ocean to be created from within a red ocean when a company expands the boundaries of an existing industry. In studying more than 150 blue ocean creations in over 30 industries, the authors observed that the traditional units of strategic analysis--company and industry--are of limited use in explaining how and why blue oceans are created. The most appropriate unit of analysis is the strategic move, the set of managerial actions and decisions involved in making a major market-creating business offering. Creating blue oceans builds brands. So powerful is blue ocean strategy, in fact, that a blue ocean strategic move can create brand equity that lasts for decades.

The constitutionality of mandatory seat belt laws.

DOT National Transportation Integrated Search

1986-01-01

Low seat belt usage rates have persisted for years despite efforts to educate people about belts' benefits. There is ample documentation of the contribution of seat belts to saving lives and reducing injury. The emotional and pecuniary toll of the fa...

The Changing Role of Women in the Armed Forces

ERIC Educational Resources Information Center

Goldman, Nancy

1973-01-01

Although there is ample reason to expect a gradual increase in numbers and a slow but steady expansion of assignment, there is little reason to believe that the all-volunteer army will be recruiting the most militant'' younger women. (Author)

DSCOVR_EPIC_L2_SO2_01

Atmospheric Science Data Center

2018-06-18

... UV and infrared sensors, offering ample opportunities for data intercomparisons and for demonstrating advanced retrievals of volcanic ash ... developed for TOMS and OMI to enable SO2 and Ash Index (AI) products from EPIC UV observations to demonstrate improved estimates of ...

Ghrelin

USDA-ARS?s Scientific Manuscript database

The gut hormone ghrelin was discovered in 1999. In the last 15 years, ample data have been generated on ghrelin. Bedsides its hallmark function as an appetite stimulator, ghrelin also has many other important functions. In this review, we discussed ghrelin's functions in learning and memory, gut mov...

Practice Update: Review of Anticonvulsant Therapy.

PubMed

Chong, Derek J; Lerman, Andrew M

2016-04-01

Since 2010, the Food and Drug Administration has approved the use of four new anti-epilepsy drugs (AEDs) for the treatment of epilepsy in the USA: clobazam (Onfi), ezogabine (Potiga), perampanel (Fycompa), and eslicarbazepine (Aptiom) as well as two extended release formulations, topiramate ER (Qudexy XR and Trokendi) and oxcarbazepine ER (Oxtellar). This not only provides practitioners ample choice to match medication profiles to their patients' preferences and co-morbidities better, but also challenges us to be proficient in the use of all. In addition to providing a brief overview of these new medications and of the current medical management of epilepsy, this review discusses new data regarding vitamin D and AED-related osteoporosis, pregnancy registries, suicidality, marijuana-related compounds for epilepsy, and the recently published guidelines on the approach and management of a first unprovoked seizure in adults and guidelines for when to stop AEDs.

Skeletal Effects of Growth Hormone and Insulin-like Growth Factor-I Therapy

PubMed Central

Lindsey, Richard C.; Mohan, Subburaman

2015-01-01

The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the regulation of bone formation, and deficiencies in this system have been shown to contribute to the development of osteoporosis and other diseases of low bone mass. The GH/IGF axis is regulated by a complex set of hormonal and local factors which can act to regulate this system at the level of the ligands, receptors, IGF binding proteins (IGFBPs), or IGFBP proteases. A combination of in vitro studies, transgenic animal models, and clinical human investigations has provided ample evidence of the importance of the endocrine and local actions of both GH and IGF-I, the two major components of the GH/IGF axis, in skeletal growth and maintenance. GH- and IGF-based therapies provide a useful avenue of approach for the prevention and treatment of diseases such as osteoporosis. PMID:26408965

[Primary care resources available in digital libraries in Spanish Autonomous Regions].

PubMed

Juan-Quilis, Verónica

2013-03-01

The Statement by the Spanish Society of Family and Community Medicine (SemFYC) on access to scientific information, highlights the need for providing digital libraries with certain resources in Autonomous Regions. The primary goal is to study the evidence-based medicine (EBM) coverage that SemFYC recommends regional virtual libraries. The regional health virtual libraries were identified and the access provided to health professionals, Internet presence, remote access and resources were studied. The results suggest there is ample coverage in 8 Autonomous Regions. At the top of the list was, Health Sciences Virtual Library of Navarre, the Balearic Islands Health Sciences Virtual Library, and Virtual Library of the Andalusian Public Health System. The present study needs to be extended to the other biomedical sciences, in order to obtain more accurate results. Copyright © 2012 Elsevier España, S.L. All rights reserved.

From coach to colleague: adjusting pedagogical approaches and attitudes in accelerated nursing programs.

PubMed

Bowie, Bonnie H; Carr, Katherine Camacho

2013-01-01

Accelerated nursing programs are an innovative approach to training nurses and advanced practice nurses that are growing steadily in number and popularity. Although there is ample evidence to show that these programs have good outcomes, acceptance by both faculty and nurses in the community remains low. This article gives a description of the accelerated nursing student, which provides some insight as to why this student is both a challenge and a joy to mentor. In addition, an overview of pedagogical approaches that may be helpful in teaching this bright group of accelerated nursing students is provided. Accelerated nursing students enrich the nursing profession with the myriad of skills and varied backgrounds they bring to nursing. As professionals, mentors, and educators, we need to not only embrace accelerated students but also be advocates and mentors for them as they assimilate into our profession. Copyright © 2013 Elsevier Inc. All rights reserved.

Obstetric "conveniences": elective induction of labor, cesarean birth on demand, and other potentially unnecessary interventions.

PubMed

Simpson, Kathleen Rice; Thorman, Kathleen E

2005-01-01

Common obstetric interventions are often for "convenience" rather than for clinical indications. Before proceeding, it should be clear who is the beneficiary of the convenience. The primary healthcare provider must make sure that women and their partners have a full understanding of what is known about the associated risks, benefits, and alternative approaches of the proposed intervention. Thorough and accurate information allows women to choose what is best for them and their infant on the basis of the individual clinical situation. Ideally, this discussion takes place during the prenatal period when there is ample opportunity to ask questions, reflect on the potential implications, and confer with partners and family members. A review of common obstetric interventions is provided. While these interventions often are medically indicated for the well-being of mothers and infants, the evidence supporting their benefits when used electively is controversial.

Assessment of the contents related to screening on Portuguese language websites providing information on breast and prostate cancer.

PubMed

Ferreira, Daniel; Carreira, Helena; Silva, Susana; Lunet, Nuno

2013-11-01

The objective of this study was to assess the quality of the contents related to screening in a sample of websites providing information on breast and prostate cancer in the Portuguese language. The first 200 results of each cancer-specific Google search were considered. The accuracy of the screening contents was defined in accordance with the state of the art, and its readability was assessed. Most websites mentioned mammography as a method for breast cancer screening (80%), although only 28% referred to it as the only recommended method. Almost all websites mentioned PSA evaluation as a possible screening test, but correct information regarding its effectiveness was given in less than 10%. For both breast and prostate cancer screening contents, the potential for overdiagnosis and false positive results was seldom addressed, and the median readability index was approximately 70. There is ample margin for improving the quality of websites providing information on breast and prostate cancer in Portuguese.

Pediatric irritable bowel syndrome and other functional abdominal pain disorders: an update of non-pharmacological treatments.

PubMed

Gupta, Shivani; Schaffer, Gilda; Saps, Miguel

2018-05-01

Functional abdominal pain disorders, including irritable bowel syndrome, are common in children and treatment can often be difficult. Pharmacological therapies and complementary treatments are widely used, despite the limited data in pediatrics. Areas covered: This review provides an overview of the available data for the use of diet, probiotics, percutaneous electrical nerve stimulation, and psychosocial interventions, including hypnotherapy, yoga, cognitive and behavioral therapy, and mind-body interventions for the treatment of functional abdominal pain disorders in children. The literature review included a PubMed search by each therapy, children, abdominal pain, and irritable bowel syndrome. Relevant articles to this review are discussed. Expert commentary: The decision on the use of pharmacological and complementary therapies should be based on clinical findings, evidence, availability, and in-depth discussion with the patient and family. The physician should provide education on the different interventions and their role on the treatment in an empathetic and warm manner providing ample time for the family to ask questions.

Tracking Three-Dimensional Fish Behavior with a New Marine Acoustic Telemetry System

NASA Technical Reports Server (NTRS)

Brosnan, Ian G.; McGarry, Louise P.; Greene, Charles H.; Steig, Tracey W.; Johnston, Samuel V.; Ehrenberg, John E.

2015-01-01

The persistent monitoring capability provided by acoustic telemetry systems allows us to study behavior, movement, and resource selection of mobile marine animals. Current marine acoustic telemetry systems are challenged by localization errors and limits in the number of animals that can be tracked simultaneously. We designed a new system to provide detection ranges of up to 1 km, to reduce localization errors to less than 1 m, and to increase to 500 the number of unique tags simultaneously tracked. The design builds on HTIs experience of more than a decade developing acoustic telemetry systems for freshwater environments. A field trial of the prototype system was conducted at the University of Washingtons Friday Harbor Marine Laboratory (Friday Harbor, WA). Copper rockfish (Sebastes caurinus) were selected for field trials of this new system because their high site-fidelity and small home ranges provide ample opportunity to track individual fish behavior while testing our ability to characterize the movements of a species of interest to management authorities.

Mitigation of wind-induced vibration of stay cables : numerical simulations and evaluations.

DOT National Transportation Integrated Search

2014-08-01

Cable-stayed bridges have been recognized as the most efficient and cost effective structural form for medium-to-long-span bridges over the past several decades. With their widespread use, cases of serviceability problems associated : with large ampl...

Discrimination against Muslim American Adolescents

ERIC Educational Resources Information Center

Aroian, Karen J.

2012-01-01

Although there is ample evidence of discrimination toward Muslim Americans in general, there is limited information specific to Muslim American adolescents. The few existing studies specific to this age group suggest that Muslim American adolescents encounter much discrimination from teachers, school administrators, and classmates. This…

Ghrelin: much more than a hunger hormone

USDA-ARS?s Scientific Manuscript database

Ghrelin is a multifaceted gut hormone that activates its receptor, growth hormone secretagogue receptor (GHS-R). Ghrelin's hallmark functions are its stimulatory effects on growth hormone release, food intake and fat deposition. Ghrelin is famously known as the 'hunger hormone'. However, ample recen...

MASTER-Kislovodsk: new OT, ampl>6m

NASA Astrophysics Data System (ADS)

Vladimirov, V.; Lipunov, V.; Gorbovskoy, E.; Tiurina, N.; Kornilov, V.; Balanutsa, P.; Kuznetsov, A.; Chazov, V.; Gress, O.; Vlasenko, D.; Pogrosheva, T.; Zimnukhov, D.; Senik, V.; Kuvshinov, D.; Rebolo, R.; Serra-Ricart, M.; Gabovich, A.

2018-05-01

MASTER-Kislovodsk auto-detection system discovered OT source at (RA, Dec) = 03h 19m 57.28s +77d 11m 22.8s on 2018-04-29.83595 UT during Fermi trigger inspection (but this OT is not connected with GRB).

Seven Habits of Highly Effective Camps.

ERIC Educational Resources Information Center

Thurber, Christopher A.

2002-01-01

Effective camps share seven habits that are essential elements of success: internal leadership development, explicit expectations for staff, ample camper preparation, personal relationships, supervisors-in-residence, two-way communication flow, and commitment to self-improvement. Three key outcomes for directors, staff, and campers resulting from…

Wind tunnel investigations of an inclined stay cable with a helical fillet.

DOT National Transportation Integrated Search

2014-09-01

Cable-stayed bridges have been recognized as the most efficient and cost effective structural form for medium-to-long-span bridges over the past several decades. With their widespread use, cases of serviceability problems associated : with large ampl...

Podiatry services for patients with arthritis: an unmet need.

PubMed

Rome, Keith; Chapman, Jonathan; Williams, Anita E; Gow, Peter; Dalbeth, Nicola

2010-03-05

Foot problems are extremely common in patients with rheumatoid arthritis (RA). There is ample evidence that foot pain, either alone or as a comorbidity, contributes significantly to disability. Despite the high prevalence of foot disease in RA, this problem is often trivialised or underappreciated. The inequity in foot health provision for patients with rheumatic disorders in New Zealand has recently been highlighted. Expertise in dealing with foot problems is often limited among healthcare professionals, and it has been argued that better integration of podiatric services into rheumatology services would be beneficial. The aim of this paper is to highlight the major issues related to foot care for patients with arthritis and provide key recommendations that should implemented to improve access to podiatric services in New Zealand.

Gender assignment in patients with disorder of sex development.

PubMed

Mendonca, Berenice B

2014-12-01

To examine the sex assignment in patients with atypical external genitalia, a particularly challenging situation, especially when the genital appearance is not compatible with the sex chromosome. The most important factors that influence sex assignment include the definite diagnosis, genital appearance, surgical options, potential for fertility, risks of gonadal malignancy and, finally, the perception of the patients and their parents. Full disclosure and complete involvement of the parents in making decisions concerning gender assignment and/or genital surgery must be part of the basic medical care for children with disorder of sex development. Patients with disorder of sex development should receive long-term care provided by multidisciplinary teams in centers of excellence with ample experience in the management of this disorder.

Chimera states: Effects of different coupling topologies

NASA Astrophysics Data System (ADS)

Bera, Bidesh K.; Majhi, Soumen; Ghosh, Dibakar; Perc, Matjaž

2017-04-01

Collective behavior among coupled dynamical units can emerge in various forms as a result of different coupling topologies as well as different types of coupling functions. Chimera states have recently received ample attention as a fascinating manifestation of collective behavior, in particular describing a symmetry breaking spatiotemporal pattern where synchronized and desynchronized states coexist in a network of coupled oscillators. In this perspective, we review the emergence of different chimera states, focusing on the effects of different coupling topologies that describe the interaction network connecting the oscillators. We cover chimera states that emerge in local, nonlocal and global coupling topologies, as well as in modular, temporal and multilayer networks. We also provide an outline of challenges and directions for future research.

Advanced Heat/Mass Exchanger Technology for Geothermal and Solar Renewable Energy Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greiner, Miles; Childress, Amy; Hiibel, Sage

2014-12-16

Northern Nevada has abundant geothermal and solar energy resources, and these renewable energy sources provide an ample opportunity to produce economically viable power. Heat/mass exchangers are essential components to any energy conversion system. Improvements in the heat/mass exchange process will lead to smaller, less costly (more efficient) systems. There is an emerging heat transfer technology, based on micro/nano/molecular-scale surface science that can be applied to heat/mass exchanger design. The objective is to develop and characterize unique coating materials, surface configurations and membranes capable of accommodating a 10-fold increase in heat/mass exchanger performance via phase change processes (boiling, condensation, etc.) andmore » single phase convective heat/mass transfer.« less

Atmospheric CO2: principal control knob governing Earth's temperature.

PubMed

Lacis, Andrew A; Schmidt, Gavin A; Rind, David; Ruedy, Reto A

2010-10-15

Ample physical evidence shows that carbon dioxide (CO(2)) is the single most important climate-relevant greenhouse gas in Earth's atmosphere. This is because CO(2), like ozone, N(2)O, CH(4), and chlorofluorocarbons, does not condense and precipitate from the atmosphere at current climate temperatures, whereas water vapor can and does. Noncondensing greenhouse gases, which account for 25% of the total terrestrial greenhouse effect, thus serve to provide the stable temperature structure that sustains the current levels of atmospheric water vapor and clouds via feedback processes that account for the remaining 75% of the greenhouse effect. Without the radiative forcing supplied by CO(2) and the other noncondensing greenhouse gases, the terrestrial greenhouse would collapse, plunging the global climate into an icebound Earth state.

The Effects of Pregnancy on Student Progress

ERIC Educational Resources Information Center

Steinkamp, Sarah Hope

2017-01-01

Ample evidence exists establishing the relationship between pregnancy during high school and subsequent educational difficulties, yet little research has investigated the relationship between pregnancy during college and subsequent educational difficulties. The purpose of this study was to determine if a relationship exists between pregnancy in…

AUTOMATED BIOCHEMICAL IDENTIFICATION OF BACTERIAL FISH PATHOGENS USING THE ABBOTT QUANTUM II

EPA Science Inventory

The Quantum II, originally designed by Abbott Diagnostics for automated rapid identification of members of Enterobacteriaceae, was adapted for the identification of bacterial fish pathogens. he instrument operates as a spectrophotometer at a wavelength of 492.600 nm. ample cartri...

Too Much or Too Little

ERIC Educational Resources Information Center

Obeng, Letitia E.

1975-01-01

All countries require an ample supply of water for agricultural and industrial uses. Most have sufficient water supplies, but availability and accessibility vary. With the development of water irrigation systems, health conditions often deteriorate. The author recommends a water management program to control quality and quantity of available…

Sports Facilities, Zapopan, Jalisco, Mexico.

ERIC Educational Resources Information Center

Amelar, Sarah

2001-01-01

Highlights a new K-12 school gymnasium in Mexico that changes and reacts to weather conditions, requires no air conditioning, and, on typical days, uses sunlight filtering through its ample clerestory as the sole source of illumination. Includes numerous photographs, a section drawing, and a site plan. (GR)

Historical Examination of the Segregated School Experience

ERIC Educational Resources Information Center

Pellegrino, Anthony M.; Mann, Linda J.; Russell, William B., III

2013-01-01

Effective history teaching includes ample opportunities for students to develop historical thinking skills and habits of mind which encourage them to learn content beyond simple acquisition of facts. Covering the profound topic of segregation by employing multiple perspectives and encouraging investigation beyond the traditional narrative provides…

Self-Censorship in Course Diaries

ERIC Educational Resources Information Center

Jay, Timothy; Brooks, Peggy

2004-01-01

Ample evidence supports the notion that keeping a course-related diary improves students' writing, knowledge of material, and awareness of psychological processes. Scant evidence supports the authenticity and completeness of diary entries. A questionnaire was developed to assess students' perceptions of self-censorship and pedagogical value of…

Job Prospects for Computer Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1988-01-01

Discusses the computer engineering industry in the United States. Recounts recent shifts in the computer industry and notes that despite foreign competition, the industry offers graduating computer engineers ample opportunities for employment. Claims that skill and technical knowledge are the most important assets for getting a job. (TW)

Sustaining observations in the polar oceans

PubMed Central

Abrahamsen, E. P.

2014-01-01

Polar oceans present a unique set of challenges to sustained observations. Sea ice cover restricts navigation for ships and autonomous measurement platforms alike, and icebergs present a hazard to instruments deployed in the upper ocean and in shelf seas. However, the important role of the poles in the global ocean circulation provides ample justification for sustained observations in these regions, both to monitor the rapid changes taking place, and to better understand climate processes in these traditionally poorly sampled areas. In the past, the vast majority of polar measurements took place in the summer. In recent years, novel techniques such as miniature CTD (conductivity–temperature–depth) tags carried by seals have provided an explosion in year-round measurements in areas largely inaccessible to ships, and, as ice avoidance is added to autonomous profiling floats and gliders, these promise to provide further enhancements to observing systems. In addition, remote sensing provides vital information about changes taking place in sea ice cover at both poles. To make these observations sustainable into the future, improved international coordination and collaboration is necessary to gain optimum utilization of observing networks. PMID:25157189

Scalar dark matter explanation of the DAMPE data in the minimal left-right symmetric model

NASA Astrophysics Data System (ADS)

Cao, Junjie; Guo, Xiaofei; Shang, Liangliang; Wang, Fei; Wu, Peiwen; Zu, Lei

2018-03-01

The left-right symmetric model (LRSM) is an attractive extension of the Standard Model (SM) that can address the origin of parity violation in the SM electroweak interactions, generate tiny neutrino masses, accommodate dark matter (DM) candidates, and provide a natural framework for baryogenesis through leptogenesis. In this work, we utilize the minimal LRSM to study the recently reported DAMPE results of the cosmic e+e- spectrum, which exhibits a tentative peak around 1.4 TeV, while satisfying the current neutrino data. We propose to explain the DAMPE peak with a complex scalar DM χ in two scenarios: (1) χ χ*→H1++H1-→ℓi+ℓi+ℓj-ℓj- , and (2) χ χ*→Hk++Hk-→ℓi+ℓi+ℓj-ℓj- accompanied by χ χ*→H1+H1-→ℓi+νℓiℓj-νℓj , with ℓi,j=e , μ , τ and k =1 , 2. We fit the theoretical prediction of the e+e- spectrum to relevant experimental data to determine the scalar mass spectrum favored by the DAMPE excess. We also consider various constraints from theoretical principles and collider experiments, as well as DM relic density and direct search experiments. We find that there is ample parameter space to interpret the DAMPE data while also passing the constraints. On the other hand, our explanations usually imply the existence of other new physics at an energy scale ranging from 107 to 1011 GeV . Collider tests of our explanations are also discussed.

Neural Representations that Support Invariant Object Recognition

PubMed Central

Goris, Robbe L. T.; Op de Beeck, Hans P.

2008-01-01

Neural mechanisms underlying invariant behaviour such as object recognition are not well understood. For brain regions critical for object recognition, such as inferior temporal cortex (ITC), there is now ample evidence indicating that single cells code for many stimulus aspects, implying that only a moderate degree of invariance is present. However, recent theoretical and empirical work seems to suggest that integrating responses of multiple non-invariant units may produce invariant representations at population level. We provide an explicit test for the hypothesis that a linear read-out mechanism of a pool of units resembling ITC neurons may achieve invariant performance in an identification task. A linear classifier was trained to decode a particular value in a 2-D stimulus space using as input the response pattern across a population of units. Only one dimension was relevant for the task, and the stimulus location on the irrelevant dimension (ID) was kept constant during training. In a series of identification tests, the stimulus location on the relevant dimension (RD) and ID was manipulated, yielding estimates for both the level of sensitivity and tolerance reached by the network. We studied the effects of several single-cell characteristics as well as population characteristics typically considered in the literature, but found little support for the hypothesis. While the classifier averages out effects of idiosyncratic tuning properties and inter-unit variability, its invariance is very much determined by the (hypothetical) ‘average’ neuron. Consequently, even at population level there exists a fundamental trade-off between selectivity and tolerance, and invariant behaviour does not emerge spontaneously. PMID:19242556

The environmental challenges in Sub-Saharan Africa.

PubMed

Mabogunje, A L

1995-05-01

Countries in sub-Saharan Africa are doing some rethinking, after decades of development that have resulted in continued poverty, international indebtedness, environmental degradation, and inappropriate Western models. Technological innovations, institutional developments, and family planning are key inputs. Development should shift to a focus on elimination of widespread poverty. Past development strategies in an African context of ample resources have harmed the environment without improving the average person's standard of living. Knowledge about Africa's environment and environmental degradation is inadequate. Recent studies have found, contrary to popular belief, that small shareholders made considerable investments in resource-based capital, which protected their farms from major environmental deterioration and negative impacts of intensification. In Nigeria field studies found that rising demand for fuelwood did not lead to greater deforestation or desertification. Severe degradation has occurred in places where density of population is greater than 500 persons per sq. km, where the land is physically or biologically vulnerable, and where socioeconomic conditions interfere with application of conservation measures. Reduced well-being and reduced food capacity is attributed to land tenure arrangements, misguided macroeconomic policies, and inadequate infrastructure. The issues of development, environment, and population are complex. Sustainable development is possible with appropriate investment priorities that will provide needed infrastructure, services, and education. Urban areas need safe water, solid waste disposal, and spatial planning to relieve congested spaces. Rural areas should focus on health education and basic sanitation. Regulatory measures and conservation measures are also important. Institutional development that promotes democracy, expands individual property rights, and increases the knowledge base offers the most hope for alleviating poverty and protecting the environment.

Outdoor Recreation at Brock University

ERIC Educational Resources Information Center

Breunig, Mary; O'Connell, Tim; Hutson, Garrett

2007-01-01

Brock University offers both undergraduate and graduate programs and is host to approximately 17,000 students. It is the only Canadian university located in a World Biosphere Reserve--the Niagara Escarpment. The Bruce Trail passes through campus, and offers ample opportunities for hiking, mountain biking, nature interpretation and outdoor…

Perceived Benefits of Human Sexuality Peer Facilitators

ERIC Educational Resources Information Center

Butler, Scott M.; Hartzell, Rose M.; Sherwood, Catherine M.

2008-01-01

Peer education, facilitation, and counseling programs are commonly utilized in primary and secondary prevention programs within colleges and universities. In addition, peer-based human sexuality discussions have been used as an adjunct to traditional human sexuality pedagogic programs over the last 20 years. Whereas ample evidence suggests that…

Promoting an Addiction to Reading

ERIC Educational Resources Information Center

Preddy, Leslie B.

2007-01-01

The author has identified three kinds of readers: (1) resistive and struggling; (2) apathetic and reluctant; and (3) effective and motivated. The resistive and struggling reader is often the reader who needs help building reading competency and confidence while creating ample opportunity for practice. These readers often respond to relationships…

Interdisciplinary Lessons in Musical Acoustics: The Science-Math-Music Connection

ERIC Educational Resources Information Center

Rogers, George L.

2004-01-01

The National Standards for Arts Education encourages teachers to help students make connections between music and other disciplines. Many state curriculum guides likewise encourage educators to integrate curricula and find common ground between different subjects. Music--particularly vocal music--offers ample opportunities to find relationships…

Identification of genes associated with low furanocoumarin content in grapefruit

USDA-ARS?s Scientific Manuscript database

Some furanocoumarins in grapefruit (Citrus paradisi) are associated with the so-called grapefruit juice effect. Previous phytochemical quantification and genetic analysis suggested that the synthesis of these furanocoumarins may be controlled by a single gene in the pathway. In this study, cDNA-ampl...

Structure of an urban Christmas tree market

Treesearch

Thomas H. Pendleton; Lawrence D. Garrett; Lawrence D. Garrett

1973-01-01

The retail Christmas tree market in Winston-Salem, N.C., was studied 3 years. Types of retailers and their sales are described. Best sales were made by dealers who had lots on heavily traveled streets in business districts, had ample parking facilities, advertised, and displayed their trees well.

An Engaging, yet Failed Flip

ERIC Educational Resources Information Center

Krahenbuhl, Kevin S.

2017-01-01

The flipped classroom is growing significantly as a model of learning in higher education. However, there are ample problems with the research on flipped classrooms, including where success is often defined by student perceptions and a lack of consistent, empirical research supporting improved academic learning. This quasi-experimental study…

Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure

EPA Science Inventory

Heart failure (HF) is defined primarily by the impairment of cardiac function and consequent inability of the heart to supply tissues with ample oxygen. To study HF etiology, investigators have applied many different techniques to elicit this condition in animals, with varying de...

Snow Bank Detectives

ERIC Educational Resources Information Center

Olson, Eric A.; Rule, Audrey C.; Dehm, Janet

2005-01-01

In the city where the authors live, located on the shore of Lake Ontario, children have ample opportunity to interact with snow. Water vapor rising from the relatively warm lake surface produces tremendous "lake effect" snowfalls when frigid winter winds blow. Snow piles along roadways after each passing storm, creating impressive snow…

UCD IIRG at TREC 2012 Medical Track

DTIC Science & Technology

2012-11-01

documents. For ex- ample, the query “shakespeare.author” would en- sure that documents matching shakespeare in the au- thor field are returned. On the...corpus side, field extents are identified using XMLlike markup, e.g. <author> shakespeare </author>. 3 System Background & Motivation This section outlines

Faculty Teaching Climate: Scale Construction and Initial Validation

ERIC Educational Resources Information Center

Knorek, John Kenneth

2012-01-01

The concept "academic culture" has been used as a framework to understand faculty work in higher education. Academic culture research builds on organizational psychology concepts of culture and climate to better understand employee practices and work phenomenon. Ample research has investigated faculty teaching at the disciplinary and…

USE OF MEMBRANE BIOREACTOR FOR BIODEGRADATION OF MTBE IN CONTAMINATED WATER1

EPA Science Inventory

An ultrafiltration membrane bioreactor was evaluated for biodegradation of methyl tert-butyl ether (MTBE) in contaminated water. The system was fed 5 mg/L MTBE in granular activated carbon (GAC) treated Cincinnati tap water containing ample buffer and nutrients. Within 120...

Children's Emotional Expressivity and Teacher Perceptions of Social Competence

ERIC Educational Resources Information Center

Louie, Jennifer Yu; Wang, Shu-wen; Fung, Joey; Lau, Anna

2015-01-01

Previous research suggests that adult perceptions of children's social competence may vary depending on the socialization goals in a given cultural context. There is also ample evidence of cultural differences in values concerning emotional display, with East Asian collectivistic contexts favoring restraint and Western individualistic contexts…

[Fire in the operating room].

PubMed

Koljonen, Virve; Mäkisalo, Heikki

2013-01-01

This article reviews the recent literature on operating room fires. Most of the reported cases have occurred from a spark from an ignition source in an oxygen-enriched atmosphere. Fire requires the presence of three components which all are ample in the operating room: heat, flammable materials or flammable gases.

Phase diagram calculations and high pressure Raman spectroscopy studies of organic "plastic crystal" thermal energy storage materials

NASA Astrophysics Data System (ADS)

Chellappa, Raja S.

This dissertation presents the phase diagram calculations and high pressure Raman spectroscopy studies on organic "plastic crystal" thermal storage materials. The organic "plastic crystals" that were studied include pentaerythritol [PE:C(CH 2OH)4], neopentylglycol [NPG:(CH3)2C(CH 2OH)2], tris(hydroxymethyl)-aminomethane [TRIS:(NH2 )C(CH2OH)3], and 2-amino-2-methyl-1,3-propanediol [AMPL: (NH2)(CH3)C(CH2OH)2]. Thermodynamic optimization of the experimental data of AMPL-NPG and PE-AMPL binary system was performed and the calculated phase diagrams are presented. A preliminary calculated phase diagram of the TRIS-NPG binary system is also presented. A thorough reevaluation of the existing calorimetric and x-ray diffraction data of the PE-AMPL binary system is also presented. This analysis resulted in the correct interpretation of the phase boundaries and a revised phase diagram has been drawn. The results of high pressure Raman spectroscopy experiments on neopentylglycol and pentaerythritol presented. The phase transformation pressures were determined by analyzing the frequency shifts as a function of pressure as well as the changes in the internal modes of vibration for these compounds. A simplified assignment of the vibrational modes for NPG at ambient pressure is presented. The results indicate experiments were carried out using Diamond Anvil Cell (DAC) and the pressure induced transformations were studied by Raman spectroscopy. In NPG, a phase transition occurs at ˜3.6 GPa from Phase I (Monoclinic) to Phase II (unknown structure). In PE, the proposed phase transformation pressures are ˜4.8 GPa (Phase I to Phase II), ˜6.9 GPa (Phase II to Phase III), ˜9.5 GPa (Phase III to Phase IV), and ˜15 GPa (Phase IV to Amorphous). The results of a critical assessment of the vapor pressure data of solid metal carbonyls. The vapor pressure data of Chromium Carbonyl (Cr(CO)6), Tungsten Carbonyl (W(CO)6 ), Osmium Carbonyl (Os3(CO)12), Molybdenum Carbonyl (MO(CO)6). Rhenium Carbonyl (Re2(CO)10), and Manganese Carbonyl (Mn(CO)5) were assessed using the "Oonk Methodology". The sublimation properties using the assessed data (Delta subGo,DeltasubH o and Deltasub Cop,m ) of these compounds have been evaluated and a discussion on the mutual consistency of various data sets for each compound over a wide range of temperature is also presented.

Using S’COOL and MY NASA DATA to Support Language Arts Instruction: Overview and Analysis

NASA Astrophysics Data System (ADS)

Moore, S. W.; Rogerson, T. M.; Chambers, L. H.; Fischer, J. D.; Oots, P. C.; Lewis, P. M.

2009-12-01

Science can serve as an authentic motivational and instructional vehicle for instruction in language arts. Two NASA educational outreach programs provide ample opportunity for strengthening vocabulary, reading comprehension, and writing skills, through the integration of authentic activities and scenarios in the context of a real-time NASA mission. The NASA CERES Students’ Cloud Observation On-Line (S’COOL) project is a hands-on project that supports NASA research on the Earth’s climate. Students are engaged in identifying cloud-types and levels and sending that information to NASA. If the students’ observations are within +/-15 minutes of the CERES satellite-based instrument passing over their location, this is designated as a “match”. The participating teacher is sent an e-mail asking the student-observers to consider the various aspects of the match, including the interpretation of a graphical aid, using the correct terminology to express level of agreement, and writing comments to describe their “matches”, all of which contribute to strengthening skills in language arts. To further integrate the language arts, the S’COOL website provides several teacher-authored on-line lessons that integrate reading skills, vocabulary, and composition. The Mentoring and inquiry using NASA Data on Atmospheric and earth science for Teachers and Amateurs (MY NASA DATA) project is a project to enable K-12 teaches and students, as well as citizen scientists, to explore the large volumes of data that NASA collects about the Earth from space. Opportunity for addressing literacy is integrated into several teacher-authored on-line lessons. Scenarios present students with a problem requiring the reading and comprehension of the scenario, understanding of terminology, the ability to read and understand a written technical procedure, and composition of related conclusions. In addition, students are provided opportunities to analyze a data-set and/or data plot, then choose correct terminology and compose hypotheses about possible patterns and anomalies. This paper will provide an overview and analysis of the use of S’COOL and MY NASA DATA to support language arts instruction.

Geographical maldistribution of pediatric medical resources in Seattle-King County.

PubMed

King, Mary A; Koelemay, Kathryn; Zimmerman, Jerry; Rubinson, Lewis

2010-01-01

Seattle-King County (SKC) Washington is at risk for regional disasters, especially earthquakes. Of 1.8 million residents, >400,000 (22%) are children, a proportion similar to that of the population of the State of Washington (24%) and of the United States (24%). The county's large area of 2,134 square miles (5,527 km2) is connected through major transportation routes that cross numerous waterways; sub-county zones may become isolated in the wake of a major earthquake. Therefore, each of SKC's three subcounty emergency response zones must have ample pediatric medical response capabilities. To date, total quantities and distribution of crucial hospital resources (available in SKC) to manage pediatric victims of a medical disaster are unknown. This study assessed whether geographical distribution of hospital pediatric resources corresponds to the pediatric population distribution in SKC. Surveys were delivered electronically to all eight acute care hospitals in SKC that admit pediatric patients. Quantities and categories of pediatric resources, including inpatient treatment space, staff, and equipment, were queried and verified via site visits. Within the seven responding hospitals of eight queried, the following were identified: 477 formal pediatric bed spaces (pediatric intensive care unit, neo-natal intensive care unit, general wards, and emergency department), 43 informal pediatric bed spaces (operating room and post-anesthesia care unit), 1,217 pediatric nurses, 554 pediatric physicians, and 252 infant/pediatric-adaptable ventilators. The City of Seattle emergency response zone contains 82.1% of bed spaces, 83.5% of nurses, and 95.8% of physicians, yet only 22.8% of all SKC children live in that zone. The majority of hospital pediatric resources are located in the SKC sub-region with the fewest children. These resources are potentially inaccessible and unable to be redistributed by ground transportation in the event of a significant regional disaster. Future planning for pediatric care in the event of a medical disaster in SKC must address this vulnerability.

Evaluating the Implementation and Effectiveness of Reflection Writing

ERIC Educational Resources Information Center

Boutet, Isabelle; Vandette, Marie-Pier; Valiquette-Tessier, Sophie-Claire

2017-01-01

There is ample theoretical justification for incorporating reflection exercises as a tool for preparing students for life beyond university, yet the utility of such exercises needs to be documented if resources are to be devoted to their implementation. This study describes the implementation and evaluates the effectiveness of a reflection…

7 CFR 1753.27 - Bidding procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE TELECOMMUNICATIONS SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Construction of Buildings § 1753.27.... (b) The borrower shall determine that title to the real estate has been approved by RUS before the invitations to bid are released. (c) The borrower shall set the time for opening of bids, allowing ample time...

A Vision of Success: How Nutrient Management Will Enhance and Sustain Ecosystem Services

EPA Science Inventory

Clean air and water, ample food, renewable fuels, productive fisheries, diverse ecosystems, resilient coasts and watersheds: these are some of the benefits that depend on sustainable nitrogen use and management. Thus, in our vision of the future, uses of reactive nitrogen are suf...

Animal Well-Being in Small Poultry Flocks: Improving bird health and product quality

USDA-ARS?s Scientific Manuscript database

Consumer interest in farm animal welfare is increasing and, while there is little legislation, voluntary welfare assurance programs exist; however, most small poultry producers do not participate in these programs. Raising birds in small flocks has some inherent welfare advantages, such as ample sp...

9 CFR 354.224 - Water supply.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

Narratives of Community Garden Education: Bridging Social Capital, Ecoliteracy, and Civic Leadership

ERIC Educational Resources Information Center

Correa, Carly K. V.

2013-01-01

Ample evidence suggests that environmental problems, and their impacts to present and future generations, require our utmost attention. Education within schools "and" communities play critical roles in shaping the perceptions and relationships people have to their natural and social environments. However, few studies have examined the…

Attention to Hierarchical Level Influences Attentional Selection of Spatial Scale

ERIC Educational Resources Information Center

Flevaris, Anastasia V.; Bentin, Shlomo; Robertson, Lynn C.

2011-01-01

Ample evidence suggests that global perception may involve low spatial frequency (LSF) processing and that local perception may involve high spatial frequency (HSF) processing (Shulman, Sullivan, Gish, & Sakoda, 1986; Shulman & Wilson, 1987; Robertson, 1996). It is debated whether SF selection is a low-level mechanism associating global…

Web-Based versus Classroom-Based Instruction: An Empirical Comparison of Student Performance

ERIC Educational Resources Information Center

Thrasher, Evelyn H.; Coleman, Phillip D.; Atkinson, J. Kirk

2012-01-01

Higher education expenditures are being increasingly targeted toward distance learning, with a large portion focused specifically on web-based instruction (WBI). WBI and classroom-based instruction (CBI) tend to offer students diverse options for their education. Thus, it is imperative that colleges and universities have ample, accurate…

Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in young healthy adults

EPA Science Inventory

Rationale: There is ample epidemiological and toxicological evidence that exposure to fme air pollution particles (PM2.5), which are primarily derived from combustion processes, can result in increased mortality and morbidity. There is less certainty as to the contribution of coa...

A Systematic Literature Review of Faculty Development for Teacher Educators

ERIC Educational Resources Information Center

Phuong, Tam T.; Cole, S. Catherine; Zarestky, Jill

2018-01-01

Although ample literature exists regarding the effectiveness of faculty development (FD) activities, there is a gap in the literature synthesizing its outcomes. This review, using a predetermined review protocol, analyzed 22 publications on FD for teacher educators using Kirkpatrick's training evaluation taxonomy. We found that North American…

9 CFR 354.224 - Water supply.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

Transforming the Early Care and Education Workforce

ERIC Educational Resources Information Center

Vecchiotti, Sara

2018-01-01

There is ample opportunity for state boards to improve outcomes for children by strengthening the early care and education workforce and thereby improving the quality of early care and education. Ensuring that ECE professionals have the knowledge, supports, and resources they need to support children's learning is one avenue to improving the…

Cross-coupling of alkenyl/aryl carboxylates with Grignard reagent via Fe-catalyzed C-O bond activation.

PubMed

Li, Bi-Jie; Xu, Li; Wu, Zhen-Hua; Guan, Bing-Tao; Sun, Chang-Liang; Wang, Bi-Qin; Shi, Zhang-Jie

2009-10-21

Iron-catalyzed cross-coupling of alkenyl/aryl carboxylates with primary alkyl Grignard reagent was described. This reaction brought a new family of electrophiles to iron catalysis. The combination of an inexpensive carboxylate electrophile and an iron catalyst would generate ample advantages.

Turning around Schools: A View from the Superintendent/Central Office as Policy Implementers

ERIC Educational Resources Information Center

Grandson, Charles A., IV

2014-01-01

This single case study examines how stakeholders of a local education agency (LEA) understand and implement state turnaround policy for its chronically underperforming schools. While there is ample research on how to improve chronically underperforming schools, a research gap exists specifically around addressing implementation of mandated…

Positive Workplace Dynamics: A Qualitative Exploration of Exceptional Performance in Community College Units

ERIC Educational Resources Information Center

Stapleton, R. Michael

2013-01-01

This companion dissertation reports the findings of applied case study research on four community college organizational units that consistently meet or exceed standard performance measures. In addition, prior ample evidence confirmed that performance extended significantly beyond what might be explained by available tangible resources alone. The…

The Regional Accreditation Process at Community Colleges: A Case Study of Effectiveness

ERIC Educational Resources Information Center

Young, Alissa L.

2013-01-01

This companion dissertation reports the findings of applied case study research on four community college organizational units that consistently meet or exceed standard performance measures. In addition, prior ample evidence confirms that performance extended significantly beyond what might be explained by available tangible resources alone. The…

Energy Storage Laboratory | Energy Systems Integration Facility | NREL

Science.gov Websites

technologies. Key Infrastructure Energy storage system inverter, energy storage system simulators, research Plug-In Vehicles/Mobile Storage The plug-in vehicles/mobile storage hub includes connections for small integration. Key Infrastructure Ample house power, REDB access, charging stations, easy vehicle parking access

Delayed Cutaneous Hypersensitivity Reactions to Antibiotics: Management with Desensitization.

PubMed

McNulty, Caitlin M G; Park, Miguel A

2017-11-01

Successful desensitization to mild to moderate delayed cutaneous adverse reaction to antibiotics has been described in a limited number of antibiotics and found to be safe. However, there are ample opportunities to standardize protocols for delayed cutaneous adverse reactions to antibiotics. Copyright © 2017 Elsevier Inc. All rights reserved.

Directory of Accredited Private Home Study Schools, 1971.

ERIC Educational Resources Information Center

National Home Study Council, Washington, DC.

This directory of accredited private home study schools lists 152 schools which have met the following standards set by the National Home Study Council: competent faculty; educationally sound and up-to-date courses; careful screening of students for admission; satisfactory educational services; demonstration of ample student success and…

Directory of Accredited Private Home Study Schools, 1970.

ERIC Educational Resources Information Center

National Home Study Council, Washington, DC.

This directory of accredited private home study schools lists 137 schools which have met the following standards set by the National Home Study Council: competent faculty; educationally sound and up-to-date courses; careful screening of students for admission; satisfactory educational services; demonstration of ample student success and…

Research Personnel: An Essay on Policy.

ERIC Educational Resources Information Center

National Commission on Research, Washington, DC.

The national need for an ample pool of research scientists is considered. Research in universities and in the federally funded research facilities is described, and the importance of the research these institutions do and the interweaving of research and instruction in universities are noted. Some manpower projections are included and questions…

Bringing Reality into the Classroom

ERIC Educational Resources Information Center

Heck, Andre

2009-01-01

Technology offers ample opportunities to bring reality into the classroom. Students and teachers nowadays have many tools to work in an authentic way with real data in mathematics and science education. However, much research and development are still needed to create a consistent learning trajectory out of the many exciting single activities.…

EFL College Students' Attitudes towards Mobile Learning

ERIC Educational Resources Information Center

Dashti, Fatimah A.; Aldashti, Abdulmohsen A.

2015-01-01

Recently, cell phones have received much attention in the context of EFL/ESL learning. Mobile learning, in general, and distant learning, in particular, in educational contexts has been approached by educationalist all over the world (Hwang & Chang, 2011). Presently, countries pay ample attention to mobile learning in education. Despite the…

MOLECULAR METHODS USED TO ASSESS THE RISKS OF TRANSGENE FLOW; BENEFITS AND LIMITATIONS

EPA Science Inventory

The US EPA WED has initiated a gene flow project to characterize ecological risks of gene flow from GM plants to native species. Development of molecular assays for risk characterization down to gene expression level is of high interest to the EPA. Phylogenetic analyses of ampl...

9 CFR 354.224 - Water supply.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

9 CFR 354.224 - Water supply.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

9 CFR 354.224 - Water supply.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

Modeling Statistical Insensitivity: Sources of Suboptimal Behavior

ERIC Educational Resources Information Center

Gagliardi, Annie; Feldman, Naomi H.; Lidz, Jeffrey

2017-01-01

Children acquiring languages with noun classes (grammatical gender) have ample statistical information available that characterizes the distribution of nouns into these classes, but their use of this information to classify novel nouns differs from the predictions made by an optimal Bayesian classifier. We use rational analysis to investigate the…

Drug Use Disorder (DUD) Questionnaire: Scale Development and Validation

ERIC Educational Resources Information Center

Scherer, Michael; Furr-Holden, C. Debra; Voas, Robert B.

2013-01-01

Background: Despite the ample interest in the measurement of substance abuse and dependence, obtaining biological samples from participants as a means to validate a scale is considered time and cost intensive and is, subsequently, largely overlooked. Objectives: To report the psychometric properties of the drug use disorder (DUD) questionnaire…

Teacher Beliefs Shape Learning for All Students

ERIC Educational Resources Information Center

Torff, Bruce

2011-01-01

Folk beliefs in our culture support less rigorous curriculum for disadvantaged students, and initiatives to encourage educators to rethink these beliefs are in order. But that's not so easily accomplished. There's ample evidence that all kinds of beliefs are resistant to change. Nonetheless, research shows that disadvantaged students could handle…

9 CFR 354.226 - Lighting and ventilation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Lighting and ventilation. 354.226 Section 354.226 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Facilities § 354.226 Lighting and ventilation. There shall be ample light, either natural or artificial or...

Flexibility in Statistical Word Segmentation: Finding Words in Foreign Speech

ERIC Educational Resources Information Center

Graf Estes, Katharine; Gluck, Stephanie Chen-Wu; Bastos, Carolina

2015-01-01

The present experiments investigated the flexibility of statistical word segmentation. There is ample evidence that infants can use statistical cues (e.g., syllable transitional probabilities) to segment fluent speech. However, it is unclear how effectively infants track these patterns in unfamiliar phonological systems. We examined whether…

Assertive Classroom Management Strategies and Students' Performance: The Case of EFL Classroom

ERIC Educational Resources Information Center

Aliakbari, Mohammad; Bozorgmanesh, Bafrin

2015-01-01

Ample research findings support the effective role that classroom management strategies play in enhancing students' learning. Drawing upon Iranian high school teachers' classroom management strategies, this article is intended to examine the extent to which these teachers follow assertive classroom management strategies and if these strategies…

Turning around Schools: A View from Teachers as Policy Implementers

ERIC Educational Resources Information Center

Chisum, Jamie B.

2014-01-01

This single case study examines how stakeholders of a local education agency (LEA) understand and implement state turnaround policy for its chronically underperforming schools. While there is ample research on how to improve chronically underperforming schools, that research becomes limited when looking at turnaround implementation actions that…

Continuous Professional Learning through School Based Strategic Planning

ERIC Educational Resources Information Center

Tytler, Russell

2007-01-01

There is ample evidence that in many countries school science is in difficulty, with declining student attitudes and uptake of science. This presentation argues that a key to addressing the problem lies in transforming teachers' classroom practice, and that pedagogical innovation is best supported within a school context. Evidence for effective…

Transformational Leadership and Organizational Commitment: A Study of UNC System Business School Department Chairs

ERIC Educational Resources Information Center

Luton, Bill

2010-01-01

Ample evidence is available citing a positive relationship between transformational leadership and organizational commitment (Boerner et al., 2007; Bono & Judge, 2003; Bycio, Hackett, & Allen, 1995; Chen, 2004; Emery & Barker, 2007; Walumbwa, Orwa, Wang, & Lawler, 2005). The majority of research on leadership in higher education,…

9 CFR 3.26 - Facilities, indoor.

Code of Federal Regulations, 2010 CFR

2010-01-01

... housing facilities for guinea pigs or hamsters shall be sufficiently heated when necessary to protect the... facilities for guinea pigs or hamsters shall have ample light, by natural or artificial means, or both, of.... Primary enclosures shall be so placed as to protect the guinea pigs or hamsters from excessive...

The Future of the Image in Critical Pedagogy

ERIC Educational Resources Information Center

Lewis, Tyson E.

2011-01-01

Although there is ample interrogation of advertising/commercial/media culture in critical pedagogy, there is little attention paid to the fine arts and to aesthetic experience. This lacuna is all the more perplexing given Paulo Freire's use of artist Francisco Brenand's illustrations ("Education for Critical Consciousness." Continuum, New York,…

Stakeholder and Process Alignment in Navy Installation Technology Transitions

DTIC Science & Technology

2017-02-01

ments are all deal-breakers if they are not addressed. For ex- ample, the UFC currently prohibit the use of stationary lithium - ion battery systems...inside occupied structures. A technology using lithium - ion batteries must get approval or a waiver for testing, evaluation and validation. If the

Turning around Schools: A View from School Leaders as Policy Implementers

ERIC Educational Resources Information Center

Geiser, Jill S.

2014-01-01

This single case study examines how stakeholders of a local education agency (LEA) understand and implement state turnaround policy for its chronically underperforming schools. While there is ample research on how to improve chronically underperforming schools, that research becomes limited when looking at turnaround implementation actions that…

Current and potential barley grain food products

USDA-ARS?s Scientific Manuscript database

Barley has been an important food source from the beginning of human civilization, and remains an important staple food crop in a few countries, although its consumption has decreased sharply with the ample availability of more palatable and versatile food crops such as rice and wheat. In many Weste...

Why Community Engagement Matters in School Turnaround

ERIC Educational Resources Information Center

McAlister, Sara

2013-01-01

Research shows that an authentically engaged community improves schools--not just by participating in school events, but also by helping to shape reform. Family and community engagement is a proven strategy for strengthening schools. There is also ample evidence that schools serving large populations of students of color and students living in…

A Case Study of the Development of an Early Retirement Program for University Faculty.

ERIC Educational Resources Information Center

Chronister, Jay L.; Trainer, Aileen

1985-01-01

To offset declining enrollments, financial constraints, younger faculties, and high tenure ratios, some institutions are considering early retirement programs to facilitate faculty turnover. A University of Virginia faculty committee reviewed several early retirement options and selected a cost-effective bridging program with ample incentives and…

49 CFR 230.43 - Gauge siphon.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Gauges § 230.43 Gauge siphon. The steam gauge supply pipe shall have a siphon on it of ample capacity to prevent steam from entering the gauge. The supply pipe shall directly enter the boiler and be maintained steam...

Study of morphological changes in breast cancer cells MCF-7 under the action of pro-apoptotic agents with laser modulation interference microscope MIM-340

NASA Astrophysics Data System (ADS)

Nebogatikov, V.; Nikitiuk, A.; Konysheva, A.; Ignatyev, P.; Grishko, V.; Naimark, O.

2017-09-01

Quantitative phase microscopy is a new method to measure and evaluate the microlevel processes characterized by the high resolution and providing ample opportunities to quantitatively analyze various parameters, including specimens from biological matter. In this study, a laser interference microscope was used to evaluate the state of cancer cells (living and apoptotic). Apoptotic cancer cells were obtained by treatment of MCF-7 cells with the use of betulin-based α-bromomethyl ketone (BMK) derivative. When using the microscope, the main differences in the morphometric parameters of living and apoptotic cells such as height, diameter, perimeter, area and volume were appraised. The criteria that can be used as markers of apoptosis activation were identified.

3-dimensional dark traps for low refractive index bio-cells using a single optical fiber Bessel beam.

PubMed

Zhang, Yu; Tang, Xiaoyun; Zhang, Yaxun; Su, Wenjie; Liu, Zhihai; Yang, Xinghua; Zhang, Jianzhong; Yang, Jun; Oh, Kyunghwan; Yuan, Libo

2018-06-15

We proposed and experimentally demonstrated 3-dimensional dark traps for low refractive index bio-cells using a single optical fiber Bessel beam. The Bessel beam was produced by concatenating single-mode fiber and a step index multimode fiber, which was then focused by a high refractive index glass microsphere integrated on the fiber end facet. The focused Bessel beam provided two dark fields along the axial direction, where stable trapping of low refractive index bio-cells was realized in a high refractive index liquid bath. The all-fiber and seamlessly integrated structure of the proposed scheme can find ample potential as a micro-optical probe in in situ characterization and manipulation of multiple bio-cells with refractive indices lower than that of the liquid bath.

Workshop Report on Ares V Solar System Science

NASA Technical Reports Server (NTRS)

Langhoff, Stephanie; Spilker, Tom; Martin, Gary; Sullivan, Greg

2008-01-01

The workshop blended three major themes: (1) How can elements of the Constellation program, and specifically, the planned Ares-V heavy-launch vehicle, benefit the planetary community by enabling the launch of large planetary payloads that cannot be launched on existing vehicles, and how can the capabilities of an Ares V allow the planetary community to redesign missions to achieve lower risk, and perhaps lower cost on these missions? (2) What are some of the planetary missions that either can be significantly enhanced or enabled by an Ares-V launch vehicle? What constraints do these mission concepts place on the payload environment of the Ares V? (3) Technology challenges that need to be addressed for launching large planetary payloads. Presentations varied in length from 15-40 minutes. Ample time was provided for discussion.

The use of solar energy for powering a portable autoclave.

PubMed

Dravid, M N; Chandak, A; Phute, S U; Khadse, R K; Adchitre, H R; Kulkarni, S D

2012-04-01

Climate change and the depletion of fossil fuels have forced the developed world to look for clean energy alternatives. Solar cooking is developing in Asian and African countries blessed with ample sun, but is still at an early stage. A portable autoclave was developed in India using this technology. The Prince-40 Concentrator provided adequate capacity to autoclave culture media and treat biomedical waste in a small laboratory set-up, and could save electricity worth Rs. 15,000 (188.10 GBP)/year or LPG worth Rs. 37,500 (470.25 GBP)/year. This technology would be of immense use in health centres in rural areas with frequent power cuts or no power supply. Copyright © 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Validation of Procedures for Monitoring Crewmember Immune Function

NASA Technical Reports Server (NTRS)

Crucian, Brian; Stowe, Raymond; Mehta, Satish; Uchakin, Peter; Quiriarte, Heather; Pierson, Duane; Sams, Clarence

2008-01-01

There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. The clinical risk (if any) from prolonged immune dysregulation during exploration-class space flight has not yet been determined, but may include increased incidence of infection, allergy, hypersensitivity, hematological malignancy or altered wound healing. Each of the clinical events resulting from immune dysfunction has the potential to impact mission critical objectives during exploration-class missions. To date, precious little in-flight immune data has been generated to assess this phenomenon. The majority of recent flight immune studies have been post-flight assessments, which may not accurately reflect the in-flight status of immunity as it resolves over prolonged flight. There are no procedures currently in place to monitor immune function or its effect on crew health. The objective of this Supplemental Medical Objective (SMO) is to develop and validate an immune monitoring strategy consistent with operational flight requirements and constraints. This SMO will assess immunity, latent viral reactivation and physiological stress during both short and long duration flights. Upon completion, it is expected that any clinical risks resulting from the adverse effects of space flight on the human immune system will have been determined. In addition, a flight-compatible immune monitoring strategy will have been developed with which countermeasures validation could be performed. This study will determine, to the best level allowed by current technology, the in-flight status of crewmembers' immune systems. The in-flight samples will allow a distinction between legitimate in-flight alterations and the physiological stresses of landing and readaptation which are believed to alter R+0 assessments. The overall status of the immune system during flight (activation, deficiency, dysregulation) and the response of the immune system to specific latent virus reactivation (known to occur during space flight) will be thoroughly assessed. The first in-flight activity for integrated immunity very recently occurred during the STS-120 Space Shuttle mission. The protocols functioned well from a technical perspective, and accurate in-flight data was obtained from 1 Shuttle and 2 ISS crewmembers. Crew participation rates for the study continue to be robust.

Possible Niches for Extant Life on Titan in Light of Cassini/Huygens Results

NASA Astrophysics Data System (ADS)

Grinspoon, D. H.; Bullock, M. A.; Spencer, J. R.; Schulze-Makuch, D.

2005-08-01

Results from the first year of the Cassini mission show that Titan has an active surface with few impact craters and abundant hints of cryovolcanism, tectonism, aeolian and fluvial activity (Porco et al., 2005; Elachi et al., 2005). Methane clouds and surface characteristics strongly imply the presence of an active global methane cycle analogous to Earth's hydrological cycle. Astrobiological interest in Titan has previously focused on possible prebiological chemical evolution on a moon with a thick nitrogen atmosphere and rich organic chemistry (Raulin and Owen, 2002). Yet the emerging new picture of Titan has raised prospects for the possibility of extant life. Several key requirements for life appear to be present, including liquid reservoirs, organic molecules and ample energy sources. One promising location may be hot springs in contact with hydrocarbon reservoirs. Hydrogenation of photochemically produced acetylene could provide metabolic energy for near-surface organisms and also replenish atmospheric methane (Schulze-Makuch and Grinspoon, 2005). The energy released could be used by organisms to drive endothermic reactions, or go into heating their surroundings, helping to create their own liquid microenvironments. In environments which are energy-rich but liquid-poor, like the near-surface of Titan, natural selection may favor organisms that use their ``waste heat" to melt their own watering holes. Downward transport of high energy photochemical compounds could provide an energy supply for near-surface organisms which could be used, in part, to maintain the liquid environments conducive to life. We will present the results of thermal modeling designed to test the feasibility of biothermal melting on Titan. C. Porco and the Cassini Imaging Team (2005) Nature 434, 159-168; C. Elachi et al, Science, 308, 970-974; F. Raulin and T. Owen (2002) Space Sci. Rev. 104, 377 - 394.; D. Schulze-Makuch and D. H. Grinspoon (2005) Astrobiology, in press.

Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance.

PubMed

Liang, Pingping; Canoura, Juan; Yu, Haixiang; Alkhamis, Obtin; Xiao, Yi

2018-01-31

DNA-modified gold nanoparticles (AuNPs) are useful signal-reporters for detecting diverse molecules through various hybridization- and enzyme-based assays. However, their performance is heavily dependent on the probe DNA surface coverage, which can influence both target binding and enzymatic processing of the bound probes. Current methods used to adjust the surface coverage of DNA-modified AuNPs require the production of multiple batches of AuNPs under different conditions, which is costly and laborious. We here develop a single-step assay utilizing dithiothreitol (DTT) to fine-tune the surface coverage of DNA-modified AuNPs. DTT is superior to the commonly used surface diluent, mercaptohexanol, as it is less volatile, allowing for the rapid and reproducible controlling of surface coverage on AuNPs with only micromolar concentrations of DTT. Upon adsorption, DTT forms a dense monolayer on gold surfaces, which provides antifouling capabilities. Furthermore, surface-bound DTT adopts a cyclic conformation, which reorients DNA probes into an upright position and provides ample space to promote DNA hybridization, aptamer assembly, and nuclease digestion. We demonstrate the effects of surface coverage on AuNP-based sensors using DTT-regulated DNA-modified AuNPs. We then use these AuNPs to visually detect DNA and cocaine in colorimetric assays based on enzyme-mediated AuNP aggregation. We determine that DTT-regulated AuNPs with lower surface coverage achieve shorter reaction times and lower detection limits relative to those for assays using untreated AuNPs or DTT-regulated AuNPs with high surface coverage. Additionally, we demonstrate that our DTT-regulated AuNPs can perform cocaine detection in 50% urine without any significant matrix effects. We believe that DTT regulation of surface coverage can be broadly employed for optimizing DNA-modified AuNP performance for use in biosensors as well as drug delivery and therapeutic applications.

Organizational downsizing: a review of literature for planning and research.

PubMed

Davis, Jullet A; Savage, Grant; Stewart, R Thomas

2003-01-01

The use of downsizing as management's strategic response to environmental and institutional changes is prevalent in all U.S. industries, including healthcare. The popular and research literature is inundated with reports on companies undergoing various stages of restructuring, which often include one or more staff reductions. This article provides a review of downsizing literature published from 1985 to 2002. Although the findings and conclusions of these articles are generally inconsistent, the prevailing opinion is that for downsizing to be successful, effective planning must occur long before, during, and after downsizing. Additionally, a downsizing plan should be included in the strategic management plan of all organizations, regardless of whether they plan to downsize or not. By including such a plan, the organization will be better prepared to begin the staff-reduction process should it be forced to do so in response to environmental changes. Finally, providing ample support and protection for staff is key to the organization's recovery and growth. The lessons provided in this literature review should assist healthcare managers in deciding how to plan and structure potential staff reductions.

Secondary metabolites from three Florida sponges with antidepressant activity.

PubMed

Kochanowska, Anna J; Rao, Karumanchi V; Childress, Suzanne; El-Alfy, Abir; Matsumoto, Rae R; Kelly, Michelle; Stewart, Gina S; Sufka, Kenneth J; Hamann, Mark T

2008-02-01

Brominated indole alkaloids are a common class of metabolites reported from sponges of the order Verongida. Herein we report the isolation, structure determination, and activity of metabolites from three Florida sponges, namely, Verongula rigida (order Verongida, family Aplysinidae), Smenospongia aurea, and S. cerebriformis (order Dictyoceratida, family Thorectidae). All three species were investigated chemically, revealing similarities in secondary metabolites. Brominated compounds, as well as sesquiterpene quinones and hydroquinones, were identified from both V. rigida and S. aurea despite their apparent taxonomic differences at the ordinal level. Similar metabolites found in these distinct sponge species of two different genera provide evidence for a microbial origin of the metabolites. Isolated compounds were evaluated in the Porsolt forced swim test (FST) and the chick anxiety-depression continuum model. Among the isolated compounds, 5,6-dibromo- N,N-dimethyltryptamine ( 1) exhibited significant antidepressant-like action in the rodent FST model, while 5-bromo- N,N-dimethyltryptamine ( 2) caused significant reduction of locomotor activity indicative of a potential sedative action. The current study provides ample evidence that marine natural products with the diversity of brominated marine alkaloids will provide potential leads for antidepressant and anxiolytic drugs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, Eun Seon; Ruminski, Anne M.; Aloni, Shaul

Interest in hydrogen fuel is growing for automotive applications; however, safe, dense, solid-state hydrogen storage remains a formidable scientific challenge. Metal hydrides offer ample storage capacity and do not require cryogens or exceedingly high pressures for operation. However, hydrides have largely been abandoned because of oxidative instability and sluggish kinetics. We report a new, environmentally stable hydrogen storage material constructed of Mg nanocrystals encapsulated by atomically thin and gas-selective reduced graphene oxide (rGO) sheets. This material, protected from oxygen and moisture by the rGO layers, exhibits exceptionally dense hydrogen storage (6.5 wt% and 0.105 kg H 2 per litre inmore » the total composite). As rGO is atomically thin, this approach minimizes inactive mass in the composite, while also providing a kinetic enhancement to hydrogen sorption performance. In conclusion, these multilaminates of rGO-Mg are able to deliver exceptionally dense hydrogen storage and provide a material platform for harnessing the attributes of sensitive nanomaterials in demanding environments.« less

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment.

PubMed

Puccinelli, Michael T; Stan, Silvia D

2017-07-28

Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and chemopreventive agent. Preclinical studies provide ample evidence that DATS regulates multiple cancer hallmark pathways including cell cycle, apoptosis, angiogenesis, invasion, and metastasis. DATS has been shown to arrest cancer cells at multiple stages of the cell cycle with the G2/M arrest being the most widely reported. Additionally, increased pro-apoptotic capacity as a result of regulating intrinsic and extrinsic apoptotic pathway components has been widely reported following DATS treatment. Invasion, migration, and angiogenesis represent emerging targets of DATS and support its anti-cancer properties. This review summarizes DATS mechanisms of action as an anti-cancer and chemopreventive agent. These studies provide rationale for future investigation into its use as a cancer chemopreventive agent.

Graphene oxide/metal nanocrystal multilaminates as the atomic limit for safe and selective hydrogen storage.

PubMed

Cho, Eun Seon; Ruminski, Anne M; Aloni, Shaul; Liu, Yi-Sheng; Guo, Jinghua; Urban, Jeffrey J

2016-02-23

Interest in hydrogen fuel is growing for automotive applications; however, safe, dense, solid-state hydrogen storage remains a formidable scientific challenge. Metal hydrides offer ample storage capacity and do not require cryogens or exceedingly high pressures for operation. However, hydrides have largely been abandoned because of oxidative instability and sluggish kinetics. We report a new, environmentally stable hydrogen storage material constructed of Mg nanocrystals encapsulated by atomically thin and gas-selective reduced graphene oxide (rGO) sheets. This material, protected from oxygen and moisture by the rGO layers, exhibits exceptionally dense hydrogen storage (6.5 wt% and 0.105 kg H2 per litre in the total composite). As rGO is atomically thin, this approach minimizes inactive mass in the composite, while also providing a kinetic enhancement to hydrogen sorption performance. These multilaminates of rGO-Mg are able to deliver exceptionally dense hydrogen storage and provide a material platform for harnessing the attributes of sensitive nanomaterials in demanding environments.

Landmarks in the historical development of twenty first century food processing technologies.

PubMed

Misra, N N; Koubaa, Mohamed; Roohinejad, Shahin; Juliano, Pablo; Alpas, Hami; Inácio, Rita S; Saraiva, Jorge A; Barba, Francisco J

2017-07-01

Over a course of centuries, various food processing technologies have been explored and implemented to provide safe, fresher-tasting and nutritive food products. Among these technologies, application of emerging food processes (e.g., cold plasma, pressurized fluids, pulsed electric fields, ohmic heating, radiofrequency electric fields, ultrasonics and megasonics, high hydrostatic pressure, high pressure homogenization, hyperbaric storage, and negative pressure cavitation extraction) have attracted much attention in the past decades. This is because, compared to their conventional counterparts, novel food processes allow a significant reduction in the overall processing times with savings in energy consumption, while ensuring food safety, and ample benefits for the industry. Noteworthily, industry and university teams have made extensive efforts for the development of novel technologies, with sound scientific knowledge of their effects on different food materials. The main objective of this review is to provide a historical account of the extensive efforts and inventions in the field of emerging food processing technologies since their inception to present day. Copyright © 2017 Elsevier Ltd. All rights reserved.

Life Support with Failures and Variable Supply

NASA Technical Reports Server (NTRS)

Jones, Harry

2010-01-01

The life support system for long duration missions will recycle oxygen and water to reduce the material resupply mass from Earth. The impact of life support failures was investigated by dynamic simulation of a lunar outpost habitat life support model. The model was modified to simulate resupply delays, power failures, recycling system failures, and storage failures. Many failures impact the lunar outpost water supply directly or indirectly, depending on the water balance and water storage. Failure effects on the water supply are reduced if Extra Vehicular Activity (EVA) water use is low and the water supply is ample. Additional oxygen can be supplied by scavenging unused propellant or by production from regolith, but the amounts obtained can vary significantly. The requirements for oxygen and water can also vary significantly, especially for EVA. Providing storage buffers can improve efficiency and reliability, and minimize the chance of supply failing to meet demand. Life support failures and supply variations can be survivable if effective solutions are provided by the system design

Social norms and their influence on eating behaviours.

PubMed

Higgs, Suzanne

2015-03-01

Social norms are implicit codes of conduct that provide a guide to appropriate action. There is ample evidence that social norms about eating have a powerful effect on both food choice and amounts consumed. This review explores the reasons why people follow social eating norms and the factors that moderate norm following. It is proposed that eating norms are followed because they provide information about safe foods and facilitate food sharing. Norms are a powerful influence on behaviour because following (or not following) norms is associated with social judgements. Norm following is more likely when there is uncertainty about what constitutes correct behaviour and when there is greater shared identity with the norm referent group. Social norms may affect food choice and intake by altering self-perceptions and/or by altering the sensory/hedonic evaluation of foods. The same neural systems that mediate the rewarding effects of food itself are likely to reinforce the following of eating norms. Copyright © 2014 Elsevier Ltd. All rights reserved.

BEHAVIORAL HAZARD IN HEALTH INSURANCE*

PubMed Central

Baicker, Katherine; Mullainathan, Sendhil; Schwartzstein, Joshua

2015-01-01

A fundamental implication of standard moral hazard models is overuse of low-value medical care because copays are lower than costs. In these models, the demand curve alone can be used to make welfare statements, a fact relied on by much empirical work. There is ample evidence, though, that people misuse care for a different reason: mistakes, or “behavioral hazard.” Much high-value care is underused even when patient costs are low, and some useless care is bought even when patients face the full cost. In the presence of behavioral hazard, welfare calculations using only the demand curve can be off by orders of magnitude or even be the wrong sign. We derive optimal copay formulas that incorporate both moral and behavioral hazard, providing a theoretical foundation for value-based insurance design and a way to interpret behavioral “nudges.” Once behavioral hazard is taken into account, health insurance can do more than just provide financial protection—it can also improve health care efficiency. PMID:23930294

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

PubMed Central

Puccinelli, Michael T.; Stan, Silvia D.

2017-01-01

Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and chemopreventive agent. Preclinical studies provide ample evidence that DATS regulates multiple cancer hallmark pathways including cell cycle, apoptosis, angiogenesis, invasion, and metastasis. DATS has been shown to arrest cancer cells at multiple stages of the cell cycle with the G2/M arrest being the most widely reported. Additionally, increased pro-apoptotic capacity as a result of regulating intrinsic and extrinsic apoptotic pathway components has been widely reported following DATS treatment. Invasion, migration, and angiogenesis represent emerging targets of DATS and support its anti-cancer properties. This review summarizes DATS mechanisms of action as an anti-cancer and chemopreventive agent. These studies provide rationale for future investigation into its use as a cancer chemopreventive agent. PMID:28788092

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung.

PubMed

O'Brien, Siobhán; Fothergill, Joanne L

2017-08-15

Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients. However, it is now recognised that a diverse microbial community exists in the airways comprising aerobic and anaerobic bacteria as well as fungi and viruses. This rich soup of microorganisms provides ample opportunity for interspecies interactions, particularly when considering secreted compounds. Here, we discuss how P. aeruginosa-secreted products can have community-wide effects, with the potential to ultimately shape microbial community dynamics within the lung. We focus on three well-studied traits associated with worsening clinical outcome in CF: phenazines, siderophores and biofilm formation, and discuss how secretions can shape interactions between P. aeruginosa and other commonly encountered members of the lung microbiome: Staphylococcus aureus, the Burkholderia cepacia complex, Candida albicans and Aspergillus fumigatus. These interactions may shape the evolutionary trajectory of P. aeruginosa while providing new opportunities for therapeutic exploitation of the CF lung microbiome. © FEMS 2017.

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

PubMed Central

Fothergill, Joanne L.

2017-01-01

Abstract Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients. However, it is now recognised that a diverse microbial community exists in the airways comprising aerobic and anaerobic bacteria as well as fungi and viruses. This rich soup of microorganisms provides ample opportunity for interspecies interactions, particularly when considering secreted compounds. Here, we discuss how P. aeruginosa-secreted products can have community-wide effects, with the potential to ultimately shape microbial community dynamics within the lung. We focus on three well-studied traits associated with worsening clinical outcome in CF: phenazines, siderophores and biofilm formation, and discuss how secretions can shape interactions between P. aeruginosa and other commonly encountered members of the lung microbiome: Staphylococcus aureus, the Burkholderia cepacia complex, Candida albicans and Aspergillus fumigatus. These interactions may shape the evolutionary trajectory of P. aeruginosa while providing new opportunities for therapeutic exploitation of the CF lung microbiome. PMID:28859314

Users guide for the Water Resources Division bibliographic retrieval and report generation system

USGS Publications Warehouse

Tamberg, Nora

1983-01-01

The WRDBIB Retrieval and Report-generation system has been developed by applying Multitrieve (CSD 1980, Reston) software to bibliographic data files. The WRDBIB data base includes some 9 ,000 records containing bibliographic citations and descriptors of WRD reports released for publication during 1968-1982. The data base is resident in the Reston Multics computer and may be accessed by registered Multics users in the field. The WRDBIB Users Guide provides detailed procedures on how to run retrieval programs using WRDBIB library files, and how to prepare custom bibliographic reports and author indexes. Users may search the WRDBIB data base on the following variable fields as described in the Data Dictionary: Authors, organizational source, title, citation, publication year, descriptors, and the WRSIC (accession) number. The Users Guide provides ample examples of program runs illustrating various retrieval and report generation aspects. Appendices include Multics access and file manipulation procedures; a ' Glossary of Selected Terms'; and a complete ' Retrieval Session ' with step-by-step outlines. (USGS)

Direct Observation in the Conduct of Training Impact Analyses

DTIC Science & Technology

2000-04-01

with the point of the pen barely extruding from the wrapper (the tight fit keeps both the pen and chemlight in place). This will put a spot of soft...recommendations for supplying that office: A-2 Snack food and beverages (your next opportunity for a meal may not be predictable) Ample supply of notepads

The Potential of Incorporating Computer Games in Foreign Language Curricula

ERIC Educational Resources Information Center

Mukundan, Jayakaran; Kalajahi, Seyed Ali Rezvani; Naghdipour, Bakhtiar

2014-01-01

There is ample evidence that technology-enhanced instruction could result in students' learning. With the advancement and ever-increasing growth of technology, the use of educational electronic games or computer games in education has appealed to both educators and students. Because of their potential to enhance students' interest, motivation and…

Hispanic Americans in the News in Two Southwestern Cities.

ERIC Educational Resources Information Center

Turk, Judy VanSlyke; And Others

1989-01-01

Examines how Hispanic Americans and Hispanic issues were covered by daily newspapers in New Mexico and Texas, two states where complaints relating to media coverage were investigated by state human rights commissions. Reports that Hispanics appear to be receiving ample and fair coverage in San Antonio, Texas, and Albuquerque, New Mexico. (MM)

Teachers' Reasons for Using Peer Assessment: Positive Experience Predicts Use

ERIC Educational Resources Information Center

Panadero, Ernesto; Brown, Gavin T. L.

2017-01-01

Peer assessment (PA) is one of the central principles of formative assessment and assessment for learning (AfL) fields. There is ample empirical evidence as to the benefits for students' learning when AfL principles are implemented. However, teachers play a critical role in mediating the implementation of intended policies. Hence, their…

Cone Analysis of Southern Pines - A Guidebook

Treesearch

D.L. Bramlett; E.W. Belcher; G.L. DeBarr; G.D. Hertel; Robert P. Karrfalt; C.W. Lantz; T. Miller; K.D. Ware; H.O. Yates

1977-01-01

Southern pine tree improvement programs require an ample supply of improved seeds, but productron from southern pine seed orchards has often been disappointing. If high productron is to be malntained yields must be monitored and causes of seed losses must be identified. Techniques for determining seed efficiency were first used for red pine, Pinus resinosa...

Confucianism on the Comeback: Current Trends in Culture, Values, Politics, and Economy

ERIC Educational Resources Information Center

Angle, Stephen C.

2010-01-01

There is ample evidence that Confucianism is undergoing a multi-faceted revival in contemporary China. This can be seen in government slogans, in a runaway best seller on the "Analects" (the compendium of Confucius's teachings), in educational experiments, and in academic activities. The twentieth century was a bad century for…

Educating for Humanity: Rethinking the Purposes of Education

ERIC Educational Resources Information Center

Seymour, Mike, Ed.

2004-01-01

The promise and necessity of working toward "a world for all" is a viable aspiration for education at a time when the worldwide crises in social justice, peace, democracy and ecological integrity have become the defining issues of our times. Ample evidence from many schools today, and dating back throughout the last century, prove that…

Ethnogenesis: Settlement and Growth of a "New People" in the Great Lakes Region, 1702-1815.

ERIC Educational Resources Information Center

Peterson, Jacqueline

1982-01-01

Following the invasion of the American Indian worlds by various European nation states, four centuries of colonization, subjugation, and intermingling have produced ample opportunity for the genesis and re-creation of bold new ethnicities and identities. An example is the Metis in the Great Lakes region. (Author/ERB)

International School Director Turnover as Influenced by School Board/Director Relationship

ERIC Educational Resources Information Center

Palsha, Zakariya S.

2017-01-01

In recent years, public school superintendents have faced increased demands from rigorous federal and state accountability standards. Yet, researchers have reported that academic improvement does not happen by chance but rather through effective leaders with ample time to implement broad, sustainable reform. The purpose of this study was to…

Ceramics Art Education and Contemporary Challenges in Nigeria

ERIC Educational Resources Information Center

Kashim, Isah Bolaji; Adelabu, Oluwafemi Samuel

2013-01-01

Formal ceramics art education is becoming a fundamental requirement for professional practice in ceramics in Nigeria. Considering the ample resources available for ceramic practices in the country with a teeming population of over 140 million people, there is a promising future for the art, in spite of the effects of globalization and…

Dropping in on the Math of Plinko

ERIC Educational Resources Information Center

Naresh, Nirmala; Royce, Bridget

2013-01-01

The game of Plinko offers students an exciting real-world example of the applications of probability and data analysis. The Common Core State Standards for Mathematics (CCSSI 2010) and the Guidelines for Assessment in Statistics Education (GAISE) (Franklin et al. 2007) suggest that students in grades 6-8 be given ample opportunities to engage in…

Research on a Modified Framework of Implicit Personality Theories

ERIC Educational Resources Information Center

Ziegler, Albert; Stoeger, Heidrun

2010-01-01

There is ample evidence that labeled gifted students exhibit maladaptive behavior patterns. According to Carol Dweck those students who subscribe to a fixed view of their abilities are particularly at risk. In this contribution we extended Dweck's framework and distinguished two aspects of the implicit theory of one's own abilities. We…

Expressive versus Receptive Language Skills in Specific Reading Disorder

ERIC Educational Resources Information Center

Stojanovik, Vesna; Riddell, Patricia

2008-01-01

Despite ample research into the language skills of children with specific reading disorder no studies so far have investigated whether there may be a difference between expressive and receptive language skills in this population. Yet, neuro-anatomical models would predict that children who have specific reading disorder which is not associated…

Conceptualizing Routines of Practice That Support Algebraic Reasoning in Elementary Schools: A Constructivist Grounded Theory

ERIC Educational Resources Information Center

Store, Jessie Chitsanzo

2012-01-01

There is ample literature documenting that, for many decades, high school students view algebra as difficult and do not demonstrate understanding of algebraic concepts. Algebraic reasoning in elementary school aims at meaningfully introducing algebra to elementary school students in preparation for higher-level mathematics. While there is research…

Personal and Contextual Factors Related to Internalizing Problems during Adolescence

ERIC Educational Resources Information Center

Oliva, Alfredo; Parra, Águeda; Reina, M. Carmen

2014-01-01

Background: Over the past decades, ample empirical evidence has been collected about the factors linked to internalizing problems during adolescence. However, there is a lack of research that use holistic approaches to study the joint analysis of a series of contextual and personal variables considered to be related to internalizing problems.…

Psychiatric Diagnoses in Historic and Contemporary Military Cohorts: Combat Deployment and the Healthy Warrior Effect

DTIC Science & Technology

2008-04-23

In general, the positive predictive value of screening questionnaires is quite poor when disease prevalence is modest/rare, as in the ex- ample of...of sensitivity, specificity, likelihood ratios and predictive values with disease prevalence . Stat Med 1997;16:981–91. 26. Wolfe J, Erickson DJ

Psychologists' Clinical Practices in Assessing Dementia in Individuals with Down Syndrome

ERIC Educational Resources Information Center

Auty, Ellen; Scior, Katrina

2008-01-01

There are now ample guidelines for the assessment and diagnosis of possible dementia in individuals with intellectual disabilities (ID) and Down syndrome. However, little is known about their implementation in clinical practice. This study set out to examine the clinical practice of one key professional group, namely clinical psychologists. A…

Teacher Perceptions of Technology Integration Professional Development an a 1:1 Chromebook Environment

ERIC Educational Resources Information Center

Yankelevich, Eleonora

2017-01-01

A variety of computing devices are available in today's classrooms, but they have not guaranteed the effective integration of technology. Nationally, teachers have ample devices, applications, productivity software, and digital audio and video tools. Despite all this, the literature suggests these tools are not employed to enhance student learning…

A Classroom Labor Market Game Illustrating the Existence, and Implications of, Statistical Discrimination

ERIC Educational Resources Information Center

Henrickson, Kevin E.

2014-01-01

Many undergraduate students report a lack of concern about facing labor market discrimination throughout their careers. However, there is ample evidence that discrimination based on race, gender, and age still persists within the labor market. The author outlines a classroom experiment demonstrating the existence of discrimination, even when the…

[Deep continuous palliative sedation in the Opinion adopted by the Italian National Bioethics Committee (Deep palliative sedation)].

PubMed

Cembrani, Fabio

2016-01-01

The Author examines the recent opinion delivered by the Italian National Committee for Bioethics on deep palliative sedation. In particular, it examines its strengths and ample shade that show its ideology, once again, in contrast with the right of every human being to die with dignity.

New Bedford, Studies of PCBs in the Acushnet River Estuary: Draft Working Copy

EPA Pesticide Factsheets

2012-04-22

... dlii;>i::n!!iii!:ii!!i, i; ampl ii I! xl; nin:: t: i oin tliiiiit!; l;itiit: i-1 n mi na t: i-> s; iii'iLiiii.'iiwiiiiinii iiunij cliEiiiiirinij p roll 1 1!! nn si ii s !i DC li at:IM:! ... Conit roll ...

Against the Odds: Academic Resilience among High-Ability African American Adolescents Living in Rural Poverty

ERIC Educational Resources Information Center

Ellis, Wendy Taylor

2010-01-01

This qualitative study investigated the internal and external protective factors that serve to ameliorate barriers to academic achievement posed by the cultural factors of poverty, minority status, and rural residence for high-ability students, rendering them academically resilient. While there has been ample research on underachievement among…

Strategies for Keeping Papers Organized.

ERIC Educational Resources Information Center

Dwyer, Edward J.

1989-01-01

The amount of paperwork in teaching often seems overwhelming. This being the case, organization is essential for effective teaching. Several ideas for dealing with paper flow are useful. Box file folders or durable plastic file cases, plus an ample supply of file folders, are excellent for storing papers. Papers used in a particular class can be…

Stereotype Threat among Schoolgirls in Quasi-Ordinary Classroom Circumstances

ERIC Educational Resources Information Center

Huguet, Pascal; Regner, Isabelle

2007-01-01

There is ample evidence today in the stereotype threat literature that women and girls are influenced by gender-stereotyped expectations on standardized math tests. Despite its high relevance to education, this phenomenon has not received much attention in school settings. The present studies offer the 1st evidence to date indicating that middle…

Discrepancies in the Ideal Perceptions and the Current Experiences of Special Education Teachers

ERIC Educational Resources Information Center

Andrews, Amanda; Brown, Jennifer L.

2015-01-01

The field of special education continues to have lower teacher retention rates compared to general education. As a result, concerns over the quality of special education teachers' professional experiences have risen. Both general and special education teachers have their ideal views of the profession, including ample classroom facilities,…

The Global Ecology Handbook: What You Can Do about the Environmental Crisis.

ERIC Educational Resources Information Center

Corson, Walter H., Ed.

There is ample evidence of the seriousness of the world's population, resource, and environmental problems--poverty and hunger, deforestation and species loss, soil erosion and desertification, air and water pollution, acid precipitation and ozone layer depletion, as well as the greenhouse effect and climate change. This handbook was prepared as a…

"We Don't Recruit, We Educate": High School Program Marketing and International Baccalaureate Programmes

ERIC Educational Resources Information Center

Donovan, Martha K.; Lakes, Richard D.

2017-01-01

Public education reformers have created a widespread expectation of school choice among school consumers. School leaders adopt rigorous academic programs, like the International Baccalaureate (IB) Diploma Programme (DP) and Career Programme (CP), to improve their market position in the competitive landscape. While ample research has investigated…

9 CFR 108.9 - Dressing rooms and other facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Dressing rooms and other facilities. 108.9 Section 108.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT... running water, soap, towels, and the like. They shall be in sufficient number, ample in size, conveniently...

Patrolling your blind spots: introspection and public catharsis in a medical school faculty development course to reduce unconscious bias in medicine.

PubMed

Hannah, Seth Donal; Carpenter-Song, Elizabeth

2013-06-01

Cultural competence education has been criticized for excessively focusing on the culture of patients while ignoring how the culture of medical institutions and individual providers contribute to health disparities. Many educators are now focusing on the role of bias in medical encounters and searching for strategies to reduce its negative impact on patients. These bias-reduction efforts have often been met with resistance from those who are offended by the notion that "they" are part of the problem. This article examines a faculty development course offered to medical school faculty that seeks to reduce bias in a way that avoids this problem. Informed by recent social-psychological research on bias, the course focuses on forms of bias that operate below the level of conscious awareness. With a pedagogical strategy promoting self-awareness and introspection, instructors encourage participants to discover their own unconscious biases in the hopes that they will become less biased in the future. By focusing on hidden forms of bias that everyone shares, they hope to create a "safe-space" where individuals can discuss shameful past experiences without fear of blame or criticism. Drawing on participant-observation in all course sessions and eight in-depth interviews, this article examines the experiences and reactions of instructors and participants to this type of approach. We "lift the hood" and closely examine the philosophy and strategy of course founders, the motivations of the participants, and the experience of and reaction to the specific pedagogical techniques employed. We find that their safe-space strategy was moderately successful, largely due to the voluntary structure of the course, which ensured ample interest among participants, and their carefully designed interactive exercises featuring intimate small group discussions. However, this success comes at the expense of considering the multidimensional sources of bias. The specific focus on introspection implies that prior ignorance, not active malice, is responsible for biased actions. In this way, the individual perpetrators of bias escape blame for their actions while the underlying causes of their behavior go unexplored or unaccounted for.

Sustaining observations in the polar oceans.

PubMed

Abrahamsen, E P

2014-09-28

Polar oceans present a unique set of challenges to sustained observations. Sea ice cover restricts navigation for ships and autonomous measurement platforms alike, and icebergs present a hazard to instruments deployed in the upper ocean and in shelf seas. However, the important role of the poles in the global ocean circulation provides ample justification for sustained observations in these regions, both to monitor the rapid changes taking place, and to better understand climate processes in these traditionally poorly sampled areas. In the past, the vast majority of polar measurements took place in the summer. In recent years, novel techniques such as miniature CTD (conductivity-temperature-depth) tags carried by seals have provided an explosion in year-round measurements in areas largely inaccessible to ships, and, as ice avoidance is added to autonomous profiling floats and gliders, these promise to provide further enhancements to observing systems. In addition, remote sensing provides vital information about changes taking place in sea ice cover at both poles. To make these observations sustainable into the future, improved international coordination and collaboration is necessary to gain optimum utilization of observing networks. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.

PubMed

Bodea, Corneliu A; Neale, Benjamin M; Ripke, Stephan; Daly, Mark J; Devlin, Bernie; Roeder, Kathryn

2016-05-05

One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level allele frequencies, releasing researchers to focus on case subjects. We argue this ideal is possible, at least theoretically, and we outline a path to achieving it in reality. If such a resource were to exist, it would yield ample savings and would facilitate the effective use of data repositories by removing administrative and technical barriers. We call this concept the Universal Control Repository Network (UNICORN), a means to perform association analyses without necessitating direct access to individual-level control data. Our approach to UNICORN uses existing genetic resources and various statistical tools to analyze these data, including hierarchical clustering with spectral analysis of ancestry; and empirical Bayesian analysis along with Gaussian spatial processes to estimate ancestry-specific allele frequencies. We demonstrate our approach using tens of thousands of control subjects from studies of Crohn disease, showing how it controls false positives, provides power similar to that achieved when all control data are directly accessible, and enhances power when control data are limiting or even imperfectly matched ancestrally. These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data. Copyright © 2016 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

The Rise of Technology in Plastic Surgery Education: Is the Textbook Dead on Arrival (DOA)?

PubMed

Waltzman, Joshua T; Tadisina, Kashyap K; Zins, James E

2016-02-01

Over the past decade there has been a dramatic rise in the use of technology. Evaluating our use of technology is crucial to advancing the next generation of plastic surgeons. The goals of this study were to assess the current use of technology by residents, help Program Directors allocate financial resources, and predict the future of technology and education. A 17-question online survey was emailed to American Society for Aesthetic Plastic Surgery resident/fellow members (n = 447). The survey evaluated current use of technology, preferred use of educational resources, and directions for the future. Ample space was allocated for free response questions. The response rate was 40%. The average age of respondents was 32 years old (standard deviation 3.7). The majority (86.5%) of residents own iPhones, and 90% of residents own tablets. There was a heavy daily reliance on smartphone technology. Sixty percent of residents used physical textbooks on a weekly basis. The Plastic Surgery Education Network was used on a weekly basis by 42% of residents. In contrast, 78% of residents were not aware of, or had never used, the readily available digital aesthetic resource (RADAR) Resource iPad application. In order to remain at the forefront of education, we as a specialty need to adapt with technology. Program Directors should support integrating technology with electronic access to educational materials. There exists an opportunity in resident education to increase awareness and utilization of the RADAR Resource. The future of plastic surgery education will be reliant on platforms like the iPhone and iPad to conveniently provide large volumes of information with only a finger touch. © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

River Boats Contribute to the Regional Spread of the Dengue Vector Aedes aegypti in the Peruvian Amazon

PubMed Central

Guagliardo, Sarah Anne; Morrison, Amy C.; Barboza, Jose Luis; Requena, Edwin; Astete, Helvio; Vazquez-Prokopec, Gonzalo; Kitron, Uriel

2015-01-01

Background and Objectives The dramatic range expansion of the dengue vector Aedes aegypti is associated with various anthropogenic transport activities, but little is known about the underlying mechanisms driving this geographic expansion. We longitudinally characterized infestation of different vehicle types (cars, boats, etc.) to estimate the frequency and intensity of mosquito introductions into novel locations (propagule pressure). Methods Exhaustive adult and immature Ae. aegypti collections were performed on six different vehicle types at five ports and two bus/ taxi departure points in the Amazonian city of Iquitos, Peru during 2013. Aquatic vehicles included 32 large and 33 medium-sized barges, 53 water taxis, and 41 speed boats. Terrestrial vehicles sampled included 40 buses and 30 taxis traveling on the only highway in the region. Ae. aegypti adult infestation rates and immature indices were analyzed by vehicle type, location within vehicles, and sampling date. Results Large barges (71.9% infested) and medium barges (39.4% infested) accounted for most of the infestations. Notably, buses had an overall infestation rate of 12.5%. On large barges, the greatest number of Ae. aegypti adults were found in October, whereas most immatures were found in February followed by October. The vast majority of larvae (85.9%) and pupae (76.7%) collected in large barges were produced in puddles formed in cargo holds. Conclusions Because larges barges provide suitable mosquito habitats (due to dark, damp cargo storage spaces and ample oviposition sites), we conclude that they likely serve as significant contributors to mosquitoes’ propagule pressure across long distances throughout the Peruvian Amazon. This information can help anticipate vector population mixing and future range expansions of dengue and other viruses transmitted by Ae. aegypti. PMID:25860352

Theory for source-responsive and free-surface film modeling of unsaturated flow

USGS Publications Warehouse

Nimmo, J.R.

2010-01-01

A new model explicitly incorporates the possibility of rapid response, across significant distance, to substantial water input. It is useful for unsaturated flow processes that are not inherently diffusive, or that do not progress through a series of equilibrium states. The term source-responsive is used to mean that flow responds sensitively to changing conditions at the source of water input (e.g., rainfall, irrigation, or ponded infiltration). The domain of preferential flow can be conceptualized as laminar flow in free-surface films along the walls of pores. These films may be considered to have uniform thickness, as suggested by field evidence that preferential flow moves at an approximately uniform rate when generated by a continuous and ample water supply. An effective facial area per unit volume quantitatively characterizes the medium with respect to source-responsive flow. A flow-intensity factor dependent on conditions within the medium represents the amount of source-responsive flow at a given time and position. Laminar flow theory provides relations for the velocity and thickness of flowing source-responsive films. Combination with the Darcy-Buckingham law and the continuity equation leads to expressions for both fluxes and dynamic water contents. Where preferential flow is sometimes or always significant, the interactive combination of source-responsive and diffuse flow has the potential to improve prediction of unsaturated-zone fluxes in response to hydraulic inputs and the evolving distribution of soil moisture. Examples for which this approach is efficient and physically plausible include (i) rainstorm-generated rapid fluctuations of a deep water table and (ii) space- and time-dependent soil water content response to infiltration in a macroporous soil. ?? Soil Science Society of America.

Hubble Uncovers a Mysterious Hermit

NASA Image and Video Library

2017-12-08

This irregular dwarf galaxy's closes neighbor is 2.3 million light years away, so yeah, we're calling it "isolated". The drizzle of stars scattered across this image forms a galaxy known as UGC 4879. UGC 4879 is an irregular dwarf galaxy — as the name suggests, galaxies of this type are a little smaller and messier than their cosmic cousins, lacking the majestic swirl of a spiral or the coherence of an elliptical. This galaxy is also very isolated. There are about 2.3 million light years between UGC 4879 and its closest neighbor, Leo A, which is about the same distance as that between the Andromeda Galaxy and the Milky Way. This galaxy’s isolation means that it has not interacted with any surrounding galaxies, making it an ideal laboratory for studying star formation uncomplicated by interactions with other galaxies. Studies of UGC 4879 have revealed a significant amount of star formation in the first 4 billion years after the Big Bang, followed by a strange 9-billion-year lull in star formation that ended 1 billion years ago by a more recent re-ignition. The reason for this behavior, however, remains mysterious, and the solitary galaxy continues to provide ample study material for astronomers looking to understand the complex mysteries of star birth throughout the universe. Image credit: NASA/ESA NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Earth observation taken by the Expedition 29 crew

NASA Image and Video Library

2011-10-07

ISS029-E-020003 (7 Oct. 2011) --- Parinacota Volcano in the Chile-Bolivia border region, South America is featured in this image photographed by an Expedition 29 crew member on the International Space Station. Volcan Parinacota (?flamingo lake? in the regional Aymara language) is a potentially active stratovolcano located on the Altiplano, a high plateau situated within the Andes Mountains of west-central South America. While no direct observations of eruptive activity are recorded, surface exposure age-dating of lava flows suggests that activity occurred as recently as 290 AD approximately 300 years, according to scientists. Local Aymara stories also suggest that the volcano has erupted during the past 1,000 years. This detailed photograph highlights the symmetrical cone of Parinacota, with its well-developed summit crater (elevation 6,348 meters above sea level) at center. Dark brown to dark gray surfaces to the east and west of the summit include lava flows, pyroclastic deposits, and ash. A companion volcano, Pomerape, is located across a low saddle to the north ? scientists believe this volcano last erupted during the Pleistocene Epoch (extending from approximately 3 million to 12,000 years ago). The summits of both volcanoes are covered by white permanent snowpack and small glaciers. Together, the two volcanoes form the Nevados de Payachata volcanic area. Eruptive activity at Parinacota has directly influenced development of the local landscape beyond the emplacement of volcanic deposits ? approximately 8,000 years ago the western flank of the volcano collapsed, creating a debris avalanche that traveled 22 kilometers to the west. This debris avalanche blocked drainages, leading to the formation of Lake Chungara to the south (upper right). The uneven, hummocky surface of the debris avalanche deposit provides ample catchments for water, as evidenced by the numerous small ponds and Cotacotani Lake to the west.

River boats contribute to the regional spread of the dengue vector Aedes aegypti in the Peruvian Amazon.

PubMed

Guagliardo, Sarah Anne; Morrison, Amy C; Barboza, Jose Luis; Requena, Edwin; Astete, Helvio; Vazquez-Prokopec, Gonzalo; Kitron, Uriel

2015-04-01

The dramatic range expansion of the dengue vector Aedes aegypti is associated with various anthropogenic transport activities, but little is known about the underlying mechanisms driving this geographic expansion. We longitudinally characterized infestation of different vehicle types (cars, boats, etc.) to estimate the frequency and intensity of mosquito introductions into novel locations (propagule pressure). Exhaustive adult and immature Ae. aegypti collections were performed on six different vehicle types at five ports and two bus/ taxi departure points in the Amazonian city of Iquitos, Peru during 2013. Aquatic vehicles included 32 large and 33 medium-sized barges, 53 water taxis, and 41 speed boats. Terrestrial vehicles sampled included 40 buses and 30 taxis traveling on the only highway in the region. Ae. aegypti adult infestation rates and immature indices were analyzed by vehicle type, location within vehicles, and sampling date. Large barges (71.9% infested) and medium barges (39.4% infested) accounted for most of the infestations. Notably, buses had an overall infestation rate of 12.5%. On large barges, the greatest number of Ae. aegypti adults were found in October, whereas most immatures were found in February followed by October. The vast majority of larvae (85.9%) and pupae (76.7%) collected in large barges were produced in puddles formed in cargo holds. Because larges barges provide suitable mosquito habitats (due to dark, damp cargo storage spaces and ample oviposition sites), we conclude that they likely serve as significant contributors to mosquitoes' propagule pressure across long distances throughout the Peruvian Amazon. This information can help anticipate vector population mixing and future range expansions of dengue and other viruses transmitted by Ae. aegypti.

Gas Dynamics in Planetary Nebulae: From Macro-structures to FLIERs

NASA Astrophysics Data System (ADS)

Perinotto, Mario

2000-10-01

Purpose of this paper is to clarify how Planetary Nebulae (PNe) are very interesting laboratories to study cosmic gas dynamics. I first recall the history of PNe which are generated from low and intermediate mass stars through successive mass loss processes starting in the Reg Giant phase of evolution and continuing also after the termination of the pulsed AGB phase, where most of the nebular mass is believed to be ejected. The correponding stellar winds are the ingredients of the nebula. Their initial properties and subsequent mutual interactions, under the action of the evolving stellar radiation field, are responsible for the properties of the nebula. The observed structures of PNe are considered in detail. Larger scale macroscopic structures (MACS) are examined separately from quite smaller scale microscopic structures (MICS). The formation of MACS, at least in cases of round to moderately elliptical PNe, is shown to be reasonably well understood in terms of existing hydrodynamical models. Considering the kinematical behaviour, MICS can be separated into FLIERs (Fast Low Ionization Emitting Regions) and SLOWERs (slowly moving). Attention is focussed on FLIERs and on the proposed mechanisms to interpret them. Recent observations with the Hubble Space Telescope have provided us with a wealth of detailed (subarcsec) information on the nebular structures. The inner structure of FLIERs is here illustrated to consist of substructures of various shapes with an high degree of individually from object to object, also within the same PN. These new data call for deeper thoretical efforts to solve the problems of cosmic gas dynamics, posed by their observed properties. An ample account is given of the most relevant original works, in an effort to allow the non specialist reader to quickly become acquainted with the status of art in the various aspects of the subject.

Population structure of resident, immigrant, and swimming Corophium volutator (Amphipoda) on an intertidal mudflat in the Bay of Fundy, Canada

NASA Astrophysics Data System (ADS)

Drolet, David; Barbeau, Myriam A.

2012-05-01

Spatial variation in biotic and abiotic conditions, and differences in dispersive behavior of different life history stages can result in the formation of zones with different demography for infaunal and epifaunal species within vast intertidal flats. In this study, we evaluated within-mudflat homogeneity of the infaunal amphipod Corophium volutator found in the mud (residents), colonizing artificially disturbed areas (immigrants), and caught in the water column (swimmers) on a large mudflat in the upper Bay of Fundy, Canada. Densities of residents, immigrants, and swimmers were well structured in space (both along and across shore). Occasionally, significant differences in size structure, sex ratio, and proportion of ovigerous females were found at different intertidal levels, but these were short-lived. Comparisons of size and sex structure of residents, immigrants, and swimmers revealed occasional marked differences, with small juveniles and large adult males moving most. However, this size-bias in movement did not translate into zones with different population dynamics, suggesting that ample dispersal, through swimming and drifting in the water column, homogenized the population and masked potential effects of variation in environmental conditions. We therefore conclude that the mudflat represents one homogeneous population.

The natural history of violence.

PubMed Central

Russell, C; Russell, W M

1979-01-01

In the past, human violence was associated with food shortage, but recently it has increased even in relatively well-fed societies. The reason appears from studies of monkeys under relaxed, spacious conditions and under crowding stress. Uncrowded monkeys have unaggressive leaders, rarely quarrel, and protect females and young. Crowded monkeys (even well-fed) have brutal bosses, often quarrel, and wound and kill each other, including females and young. Crowding has similar behaviour effects on other mammals, with physiological disturbances including greater susceptibility to infections. All this appears to be a regular response to overpopulation, reducing the population before it has depleted its natural resources. Human beings, like monkeys and other mammals, need ample space, and become more violent when crowded. Human history is marked by population cycles: population outgrows resources, the resulting violence, stress and disease mortality cuts down the population, leading to a relief period of social and cultural progress, till renewed population growth produces the next crisis. The modern population crisis is world-wide, and explains the increase of violence even in well-fed societies. The solution to the problem of violence is to substitute voluntary birth control for involuntary death control, and bring about relaxed conditions for a reduced world population. PMID:114662

Scheduling Multilevel Deadline-Constrained Scientific Workflows on Clouds Based on Cost Optimization

DOE PAGES

Malawski, Maciej; Figiela, Kamil; Bubak, Marian; ...

2015-01-01

This paper presents a cost optimization model for scheduling scientific workflows on IaaS clouds such as Amazon EC2 or RackSpace. We assume multiple IaaS clouds with heterogeneous virtual machine instances, with limited number of instances per cloud and hourly billing. Input and output data are stored on a cloud object store such as Amazon S3. Applications are scientific workflows modeled as DAGs as in the Pegasus Workflow Management System. We assume that tasks in the workflows are grouped into levels of identical tasks. Our model is specified using mathematical programming languages (AMPL and CMPL) and allows us to minimize themore » cost of workflow execution under deadline constraints. We present results obtained using our model and the benchmark workflows representing real scientific applications in a variety of domains. The data used for evaluation come from the synthetic workflows and from general purpose cloud benchmarks, as well as from the data measured in our own experiments with Montage, an astronomical application, executed on Amazon EC2 cloud. We indicate how this model can be used for scenarios that require resource planning for scientific workflows and their ensembles.« less

Description of CASCOMP Comprehensive Airship Sizing and Performance Computer Program, Volume 2

NASA Technical Reports Server (NTRS)

Davis, J.

1975-01-01

The computer program CASCOMP, which may be used in comparative design studies of lighter than air vehicles by rapidly providing airship size and mission performance data, was prepared and documented. The program can be used to define design requirements such as weight breakdown, required propulsive power, and physical dimensions of airships which are designed to meet specified mission requirements. The program is also useful in sensitivity studies involving both design trade-offs and performance trade-offs. The input to the program primarily consists of a series of single point values such as hull overall fineness ratio, number of engines, airship hull and empennage drag coefficients, description of the mission profile, and weights of fixed equipment, fixed useful load and payload. In order to minimize computation time, the program makes ample use of optional computation paths.

Research in remote sensing of vegetation

NASA Technical Reports Server (NTRS)

Schrumpf, Barry J.; Ripple, William J.; Isaacson, Dennis L.

1988-01-01

The research topics undertaken were primarily selected to further the understanding of fundamental relationships between electromagnetic energy measured from Earth orbiting satellites and terrestrial features, principally vegetation. Vegetation is an essential component in the soil formation process and the major factor in protecting and holding soil in place. Vegetation plays key roles in hydrological and nutrient cycles. Awareness of improvement or deterioration in the capacity of vegetation and the trends that those changes may indicate are, therefore, critical detections to make. A study of the relationships requires consideration of the various portions of the electromagnetic spectrum; characteristics of detector system; synergism that may be achieved by merging data from two or more detector systems or multiple dates of data; and vegetational characteristics. The vegetation of Oregon is sufficiently diverse as to provide ample opportunity to investigate the relationships suggested above several vegetation types.

Worldwide surplus of LP-gases to grow, expert tells European meet in Venice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-07-01

There appears to be a growing consensus among students of the LP-gas industry that (1) the worldwide surplus of supplies of LP-gases will continue and grow, and (2) this will provide ample opportunity for market development between now and the year 2000, but (3) that development will be largely in the field of petro-chemical feedstocks, although (4) if the price should not remain competitive with feedstocks such as naphtha, the surpluses could find their way into the U.S., if (5) the price is right. This viewpoint was set forth for the benefit of the delegates to the convention May 19-20more » of the European LP-Gas Association in Venice, Italy, by Rick Haun, vice president of Purvin and Gertz, the Dallas consulting firm.« less

The Oklahoma bombing. Lessons learned.

PubMed

Anteau, C M; Williams, L A

1997-06-01

The Oklahoma City bombing experience in April of 1995 provided a unique opportunity to test the effectiveness of an existing disaster plan. The critical care nurses at Columbia Presbyterian Hospital learned valuable lessons about managing intense activity, equipment and supplies, staffing resources, and visitor issues. The degree to which the bombing affected the emotional state of personnel was unanticipated, and leaders learned that critical stress management interventions should be included in every emergency preparedness plan. Additionally, recommendations include using runners for communication; assigning specific roles (supplies, staffing, triage); keeping additional staff in reserve for shift relief; ensuring ample hospital staff members are available to coordinate visitors and media; and setting up record systems to preserve continuity. The unique lessons learned as a result of this terrorist attack can be used by other critical care nurses to understand and refine disaster plans.

Differences in Physical and Mental Health Symptoms and Mental Health Utilization Associated With Intimate-Partner Violence Versus Childhood Abuse

PubMed Central

Nicolaidis, Christina; McFarland, Bentson; Curry, MaryAnn; Gerrity, Martha

2009-01-01

Background There is ample evidence that both intimate-partner violence (IPV) and childhood abuse adversely affect the physical and mental health of adult women over the long term. Objective The authors assessed the associations between abuse, symptoms, and mental health utilization. Method The authors performed a cross-sectional survey of 380 adult female, internal-medicine patients. Results Although both IPV and childhood abuse were associated with depressive and physical symptoms, IPV was independently associated with physical symptoms, and childhood abuse was independently associated with depression. Women with a history of childhood abuse had higher odds, whereas women with IPV had lower odds, of receiving care from mental health providers. Conclusion IPV and childhood abuse may have different effects on women’s symptoms and mental health utilization. PMID:19687174

Microsatellite DNA markers for assessing phylogeographic and population structure in Preble's meadow jumping mice (Zapus hudsonius preblei) and cross-amplification among neighbouring taxa

USGS Publications Warehouse

King, T.L.; Eackles, M.S.; Young, C.

2006-01-01

We document the isolation and characterization of 14 tetranucleotide microsatellite DNA markers in Preble's meadow jumping mouse (Zapus hudsonius preblei). The identified markers displayed moderate levels of allelic diversity (averaging 4.9 alleles per locus) and heterozygosity (averaging 55.1%). Genotypic and allelic frequencies in a collection of 30 individuals conformed to Hardy-Weinberg equilibrium expectations and indicated no linkage disequilibrium. High levels of cross-amplification (95% overall) among neighbouring subspecies and two congeners (Zapus princeps and Zapus trinotatus) were observed. Multilocus genotypes resulting from these markers appear to provide ample genetic diversity for studies assessing individual- and population-level ecological interactions within Z. h. preblei and evolutionary relationships among neighbouring subspecies (Z. h. campestris, Z. h. intermedius, Z. h. pallidus and Z. h. luteus). ?? 2006 The Authors.

Improving Transportation Services for the University of the Thai Chamber of Commerce: A Case Study on Solving the Mixed-Fleet Vehicle Routing Problem with Split Deliveries

NASA Astrophysics Data System (ADS)

Suthikarnnarunai, N.; Olinick, E.

2009-01-01

We present a case study on the application of techniques for solving the Vehicle Routing Problem (VRP) to improve the transportation service provided by the University of The Thai Chamber of Commerce to its staff. The problem is modeled as VRP with time windows, split deliveries, and a mixed fleet. An exact algorithm and a heuristic solution procedure are developed to solve the problem and implemented in the AMPL modeling language and CPLEX Integer Programming solver. Empirical results indicate that the heuristic can find relatively good solutions in a small fraction of the time required by the exact method. We also perform sensitivity analysis and find that a savings in outsourcing cost can be achieved with a small increase in vehicle capacity.

The preconceptional period as an opportunity for prediction and prevention of noncommunicable disease.

PubMed

Hadar, Eran; Ashwal, Eran; Hod, Moshe

2015-01-01

Preconceptional care is a set of interventions, aimed to identify and modify medical, behavioral, and social risks to a woman's health and her pregnancy outcome, prior to conception. Diagnosing and treating some of the common noncommunicable diseases (NCDs) may have an impact on pregnancy outcome. Ample time should be allowed to properly intervene in some of the following situations: hypertension, diabetes, obesity, systemic lupus erythematosus, thyroid disease, anemia, epilepsy, asthma, and cardiac disease. Diabetes mellitus and obesity are common NCDs, with proven efficacy for preconceptional care, for both maternal and perinatal outcome. These primary components of the metabolic syndrome, if properly treated prior to pregnancy, will prevent long-term hazards for the mother, her children, and the next generations, by providing in utero primary prevention of NCDs. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Lifestyle medicine: the importance of considering all the causes of disease].

PubMed

Mora Ripoll, Ramón

2012-01-01

The enormous potential effects of health behavior change on mortality, morbidity, and health care costs provide ample motivation for the concept of lifestyle medicine. Lifestyle medicine involves the therapeutic use of lifestyle interventions on health and quality of life, and considers not only risk factors and markers, but also a range of antecedent factors from all levels of causality. Treatment would ultimate employ a combination of clinical (patient-centered) and public-health interventions. Examples of target patient behaviors include, but are not limited to, eliminating tobacco use, moderating alcohol consumption, increasing physical activity, improving diet, sleep, and emotional and mental well-being. The effective implementation of lifestyle medicine should be a priority within the necessary changes in current healthcare systems and public health policies. Copyright © 2010 SEP y SEPB. Published by Elsevier Espana. All rights reserved.

The Colorado School of Mines Nevada geothermal study

NASA Technical Reports Server (NTRS)

Keller, G. V.; Grose, L. T.; Crewpson, R. A.

1974-01-01

Geothermal systems in the Basin and Range Province of the western United States probably differ in many respects from geothermal systems already discovered in other parts of the world because of the unique tectonic setting. To investigate this, a study of the geothermal occurrences at Fly Ranch, approximately 100 miles north of Reno, Nevada, has been undertaken. Ample evidence for a geothermal system exists in this area, including the surface expression of heat flow in the form of hot springs, an extensive area of low electrical resistivity, and a high level of seismicity along faults bounding the thermal area. However, geophysical and geological studies have not yet provided evidence for a local heat source at depth. Additional detailed geophysical and geological studies, as well as drilling, must be completed before the geothermal system can be described fully.

The role of sleep in human declarative memory consolidation.

PubMed

Alger, Sara E; Chambers, Alexis M; Cunningham, Tony; Payne, Jessica D

2015-01-01

Through a variety of methods, researchers have begun unraveling the mystery of why humans spend one-third of their lives asleep. Though sleep likely serves multiple functions, it has become clear that the sleeping brain offers an ideal environment for solidifying newly learned information in the brain. Sleep , which comprises a complex collection of brain states, supports the consolidation of many different types of information. It not only promotes learning and memory stabilization, but also memory reorganization that can lead to various forms of insightful behavior. As this chapter will describe, research provides ample support for these crucial cognitive functions of sleep . Focusing on the declarative memory system in humans, we review the literature regarding the benefits of sleep for both neutral and emotionally salient declarative memory. Finally, we discuss the literature regarding the impact of sleep on emotion regulation.

Disembodied Creativity: The Role of Action Research in Moderating Educator Expectations of Marketing and Public Relations Students

ERIC Educational Resources Information Center

Fordham, Helen

2015-01-01

Despite ample research indicating creativity is valuable in creating a competitive advantage and enabling individual success in the global knowledge economy, there are still industry concerns about how adequately individual student's creative abilities are developed for the workplace (McCorkle, Payan, Reardon & Kling, 2007). In considering how…

26 CFR 20.6011-1 - General requirement of return, statement, or list.

Code of Federal Regulations, 2010 CFR

2010-04-01

... prescribed by §§ 20.6018-1 and 20.6036-1 may be obtained from district directors. The fact that an executor... in ample time for the executor to have the form prepared, verified, and filed with the appropriate....6075-1). The executor shall carefully prepare the return and, if applicable, the preliminary notice so...

Assessing Soldier Individual Differences to Enable Tailored Training

DTIC Science & Technology

2010-04-01

upon effective and efficient training. However, there is ample evidence that learning-related individual differences exist ( Thorndike , 1985; Jensen...in both civilian and military settings (Schmidt, Hunter, & Outerbridge, 1986; Thorndike , 1985). Prior knowledge or knowledge of facts and...predictive power ( Thorndike , 1985; Jensen, 1998). Further, there is a good deal of evidence that general mental ability impacts performance largely

Cross-VM Side Channels and Their Use to Extract Private Keys

DTIC Science & Technology

2012-10-16

clouds such as Amazon EC2 and Rackspace, but also by other Xen use cases. For ex- 4 ample, many virtual desktop infrastructure ( VDI ) solutions (e.g...whose bit length is, for example, 337, 403, or 457 when κ is 2048 , 3072, or 4096, respectively. We note that this deviates from standard ElGamal, in

Community Alert: Using Text Messaging and Social Media to Improve Campus Emergency Planning

ERIC Educational Resources Information Center

Connolly, Maureen

2014-01-01

This article describes emergency management and the part that social media technologies and mobile messaging have made when they are included as part of the campus emergency plan. Administrators have found that ample notification and preparedness must be built into campus communication systems. Social media platforms such as Twitter and Facebook…

College Students and Personal Finance: Exploring the Relationships among Financial Well-Being, Money Management Practices, and Engagement in Personal Finance Education

ERIC Educational Resources Information Center

Davtyan, Arman

2010-01-01

Despite ample evidence of the relative financial illiteracy of students in college, personal finance education remains inconsistent across postsecondary institutions in the United States. Moreover, existing programs and services related to personal finance education have had modest success in attracting student interest and participation. To…

The Primacy of Perceiving: Emotion Recognition Buffers Negative Effects of Emotional Labor

ERIC Educational Resources Information Center

Bechtoldt, Myriam N.; Rohrmann, Sonja; De Pater, Irene E.; Beersma, Bianca

2011-01-01

There is ample empirical evidence for negative effects of emotional labor (surface acting and deep acting) on workers' well-being. This study analyzed to what extent workers' ability to recognize others' emotions may buffer these effects. In a 4-week study with 85 nurses and police officers, emotion recognition moderated the relationship between…

76 FR 65885 - Medicare Program; Changes to the Ambulatory Surgical Centers Patient Rights Conditions for Coverage

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... patient travel issues. They believe the CfC should be expanded so that urgent (nonemergency) procedures... inconveniences and patient travel issues. After considering the public comments and the potential negative impact... patient prior to the start of the surgical procedure. With this new requirement, ASCs will have ample time...

Full-Tree SKidding Black Spruce: Another Way to Favor Reproduction

Treesearch

William F. Johnston

1975-01-01

An alternative to burning is needed for clearcut peatlands where only slash disposal is required to rapidly reproduce black spruce. A 2-year trial in north-central Minnesota indicates that reproduction will be rapid after full-tree skidding on nonbrushy sites taht have well-distribted sphagnum seedbeds and ample natural seeding. Broadcast burning is still recommended...

The Impact of Subject Indexes on Semantic Indeterminacy in Enterprise Document Retrieval

ERIC Educational Resources Information Center

Schymik, Gregory

2012-01-01

Ample evidence exists to support the conclusion that enterprise search is failing its users. This failure is costing corporate America billions of dollars every year. Most enterprise search engines are built using web search engines as their foundations. These search engines are optimized for web use and are inadequate when used inside the…

Making a Literacy Plan: Developing an Integrated Curriculum That Meets Your School's Needs

ERIC Educational Resources Information Center

Schutte, Annie

2016-01-01

Literacy does not happen in a single lesson or course. There are no shortcuts to gaining mastery over a skill set, whether it is reading literacy, information literacy and research skills, online literacy and digital citizenship, or visual literacy. School librarians dream about a perfect integrated curriculum: there is ample time for…

Canopy temperature and maturity in cotton

USDA-ARS?s Scientific Manuscript database

Heat units are a widely used indicator of maturity in cotton. It is generally assumed that it takes approximately 2200°F (1222°C) heat units for a cotton plant on the South High Plains of Texas to mature. This value is based on a typical planting date of May 15 with ample irrigation. As water for c...

Helping School Leaders Help New Teachers: A Tool for Transforming School-Based Induction

ERIC Educational Resources Information Center

Birkeland, Sarah; Feiman-Nemser, Sharon

2012-01-01

Ample research demonstrates the power of comprehensive induction to develop and retain new teachers. Education scholars generally agree on what powerful systems of induction include, yet few tools exist for guiding schools in creating such systems. Drawing on theory and practice, we have created such a tool. This article introduces the "Continuum…

A Case Study on the Influence of Frequent Superintendent Turnover on the Culture of a K-12 Suburban School District

ERIC Educational Resources Information Center

Velazquez, Victoria C.

2017-01-01

The role of school superintendents is varied and complex. Further complicating this role is the issue of frequent superintendent turnover. While there is ample research addressing the links between superintendents and student achievement, superintendents' relationships with school boards and the shortage of qualified superintendents across the…

In the Eye of the Beholder: Eye-Tracking Assessment of Social Information Processing in Aggressive Behavior

ERIC Educational Resources Information Center

Horsley, Tako A.; de Castro, Bram Orobio; Van der Schoot, Menno

2010-01-01

According to social information processing theories, aggressive children are hypersensitive to cues of hostility and threat in other people's behavior. However, even though there is ample evidence that aggressive children over-interpret others' behaviors as hostile, it is unclear whether this hostile attribution tendency does actually result from…

The Use of a Student Group Log to Facilitate Student and Teacher Learning

ERIC Educational Resources Information Center

Coenders, Fer

2016-01-01

In 21st century education students should have ample opportunities to collaborate on authentic problems. Many teachers however find it difficult to make the transfer from teacher to student-centered education. Giving students autonomy can be disquieting to teachers, as they fear to lose control of student learning. Teachers in a teacher…

Towards a Dynamic Conceptual Framework for English-Medium Education in Multilingual University Settings

ERIC Educational Resources Information Center

Dafouz, Emma; Smit, Ute

2016-01-01

At a time of increasing internationalization in tertiary education, English-Medium Education in Multilingual University Settings (EMEMUS) has become a common practice. While there is already ample research describing this phenomenon at a local level (Smit and Dafouz 2012a), the theoretical side needs to be elaborated. This article thus aims to…

The Major Environmentally-Based Land Use Issues on the Urban Fringe.

ERIC Educational Resources Information Center

Hordon, Robert M.

Types of land-use issues which form current problems in urban areas are discussed in this paper. The majority of these environmentally based issues revolve around the management of water. The five most often encountered water-oriented issues are denoted in rank order of importance. First, an ample water supply which is free from contamination must…

Not All Emotions Are Created Equal: The Negativity Bias in Social-Emotional Development

ERIC Educational Resources Information Center

Vaish, Amrisha; Grossman, Tobias; Woodward, Amanda

2008-01-01

There is ample empirical evidence for an asymmetry in the way that adults use positive versus negative information to make sense of their world; specifically, across an array of psychological situations and tasks, adults display a negativity bias, or the propensity to attend to, learn from, and use negative information far more than positive…

Opportunities in ESSA for Improving Early Education. Education Leaders Report. Volume 2, No. 3

ERIC Educational Resources Information Center

Dichter, Harriet

2016-01-01

For the first time, the nation's most important federal education law, the Every Student Succeeds Act (ESSA), prominently features early childhood education. State and local leaders now have ample flexibility and opportunity to focus on early education as a foundational element of ESSA while advancing their state's vision and goals for early…

From Early Starters to Late Finishers? A Longitudinal Study of Early Foreign Language Learning in School

ERIC Educational Resources Information Center

Jaekel, Nils; Schurig, Michael; Florian, Merle; Ritter, Markus

2017-01-01

Foreign language education has now been implemented at the elementary school level across Europe, and early foreign language education has gained traction following language policies set by the European Commission. The long-term effects of an early start, however, have not received ample scientific scrutiny. The present study assessed early…

Ensuring That Family Engagement Initiatives Are Successful, Sustainable, and Scalable

ERIC Educational Resources Information Center

Geller, Joanna D.

2016-01-01

In 2009, the U.S. Department of Education launched the highly competitive Investing in Innovation (i3) initiative. School districts and nonprofit partners nationwide have competed for coveted funds to develop a new program, validate an existing program with some evidence of success, or scale up a program backed by ample evidence. Very quickly,…

A Role for History and Philosophy of Biology in Exploring New Questions in Biology

ERIC Educational Resources Information Center

Daggett, Melissa A. F.

2012-01-01

A number of current reports are challenging educators of undergraduate biology students to increase the role, interactions and approaches of other disciplines. The goal stated in these reports is to produce a college graduate with the skills and competencies to solve pressing global problems such as producing ample food, fuels, and making health…

Middle School Pupil Writing and the Word Processor.

ERIC Educational Resources Information Center

Ediger, Marlow

Pupils in middle schools should have ample opportunities to write with the use of word processors. Legible writing in longhand will always be necessary in selected situations but, nevertheless, much drudgery is taken care of when using a word processor. Word processors tend to be very user friendly in that few mechanical skills are needed by the…

Disentangling the Effects of Context Change and Context Familiarity on Latent Inhibition with a Conditioned Taste Aversion Procedure

ERIC Educational Resources Information Center

De la Casa, L. G.; Mena, A.; Orgaz, A.; Fernandez, A.

2013-01-01

Contextual specificity of Latent Inhibition (LI) has been demonstrated using an ample range of experimental procedures. Context dependence has not been consistently obtained, however, when LI has been induced using a Conditioned Taste Aversion (CTA) procedure. This paper presents two experiments designed to analyze whether the context plays the…

Multilocus analyses reveal little evidence for lineage-wide adaptive evolution within major clades of soft pines (Pinus subgenus Strobus)

Treesearch

Andrew J. Eckert; Andrew D. Bower; Kathleen D. Jermstad; Jill L. Wegrzyn; Brian J. Knaus; John V. Syring; David B. Neale

2013-01-01

Estimates from molecular data for the fraction of new nonsynonymous mutations that are adaptive vary strongly across plant species. Much of this variation is due to differences in life history strategies as they influence the effective population size (Ne). Ample variation for these estimates, however, remains even when...

Improving Children's Life Chances: Estimates from the Social Genome Model

ERIC Educational Resources Information Center

Grannis, Kerry Searle; Sawhill, Isabel

2013-01-01

There is ample evidence that children born to poorer families do not succeed at the same rate as children born to the middle class. On average, low-income children lag behind on almost every cognitive, behavioral, emotional, and health measure. These gaps start early--some of the newest research suggests that cognitive gaps are detectable in…

The Effectiveness of Processing Instruction in L2 Grammar Acquisition: A Narrative Review

ERIC Educational Resources Information Center

Dekeyser, Robert; Botana, Goretti Prieto

2015-01-01

The past two decades have seen ample debate about processing instruction (PI) and its various components. In this article, we first describe what PI consists of and then address three questions: about the role of explicit information (EI) in PI, the difference between PI and teaching that incorporates production-based (PB) practice, and various…

Environmental Education 2.0: Toward a Theory of Ecologically Minded Teaching

ERIC Educational Resources Information Center

Morrison, Scott A.

2013-01-01

Since the 1970s, the environmental education movement has been positioned as one of the primary means to cultivate the knowledge, values, dispositions, and behavior needed to preserve and protect the planet. Ample research suggests, however, that environmental education has failed to meet its goals, and that the state of the environment is…

Serving on Your Local School Board: A Foundation for Success

ERIC Educational Resources Information Center

Washington State School Directors' Association (NJ1), 2011

2011-01-01

Governing public schools is one of the most important responsibilities a citizen can undertake. School board members work on behalf of all the families in their community, with fellow board members and with other community partners, to ensure that each student has equal and ample opportunities to reach his or her greatest potential. This guide…

"We Won't Get Ahead Speaking like That!" Expressing and Managing Language Criticism in Hawai'i

ERIC Educational Resources Information Center

Marlow, Mikaela L.; Giles, Howard

2010-01-01

Ample research has explored language attitudes and speaker evaluations, yet it has not attended to direct incidences of language criticism. This article presents evidence demonstrating that a majority of those surveyed in Hawai'i have experienced language criticism. Coded data suggest that criticism takes place during employment, educational,…

A Reflection on Plagiarism, Patchwriting, and the Engineering Master's Thesis

ERIC Educational Resources Information Center

Eckel, Edward J.

2010-01-01

Early in his career as an engineering librarian, the author saw plagiarism in completely black and white terms. However, digging into the scholarly literature, he finds ample evidence that there are other factors at work in student writing besides a lack of ethics or the intent to cheat. In this article, he briefly highlights some of these…

Well-Being and Economic Freedom: Evidence from the States

ERIC Educational Resources Information Center

Belasen, Ariel R.; Hafer, R. W.

2012-01-01

There is ample evidence that well-being, measured in various ways for a large number of countries, is positively related to the level of general intelligence. Pesta at al. (2010a) verify this close relationship between well-being and IQ across states. There also is evidence that well-being is positively related to economic freedom across…

Perceiving Permutations as Distinct Outcomes: The Accommodation of a Complex Knowledge System

ERIC Educational Resources Information Center

Kapon, Shulamit; Ron, Gila; Hershkowitz, Rina; Dreyfus, Tommy

2015-01-01

There is ample evidence that reasoning about stochastic phenomena is often subject to systematic bias even after instruction. Few studies have examined the detailed learning processes involved in learning probability. This paper examines a case study drawn from a large corpus of data collected as part of a research project that dealt with the…

Identifying Factors That Are Most Influential in Veteran Teachers Seriously Considering Leaving the Profession

ERIC Educational Resources Information Center

Culkin, Michaela A.

2016-01-01

This study investigated the factors most influential when veteran teachers seriously consider leaving the teaching profession. Teachers in the education profession who are in the later stages of their careers hold the experience that benefits all who teach in schools. There is ample literature discussing why new teachers leave the profession, but…

The Mediating Effects of Parenting Behaviors on Maternal Affect and Reports of Children's Behavior

ERIC Educational Resources Information Center

Karazsia, Bryan T.; Wildman, Beth G.

2009-01-01

Parenting behaviors have received ample support as a mediator of the relationship between maternal affect and child behavior problems. The majority of these research efforts were based on a uni-dimensional conceptualization of maternal mood, even though decades of theory and research suggest that mood is multidimensional. We examined the mediating…

Arts Infusion and Literacy Achievement within Underserved Communities: A Matter of Equity

ERIC Educational Resources Information Center

Carney, Charles L.; Weltsek, Gustave J.; Hall, M. Lynne; Brinn, Ginger

2016-01-01

There is ample evidence that arts added to the K-12 curriculum can have many positive learning impacts. Nevertheless, many states do not promote such instruction as an integral part of classroom plans. For particular schools with underserved populations, arts-enhanced curricula can be a powerful learning tool. Beyond arts integration, arts…

How Does Location Impact Meaning and Opportunity? Rural Schools and the NCATE Diversity Standard

ERIC Educational Resources Information Center

Miretzky, Debra; Stevens, Sharon

2012-01-01

Background/Context: While there is ample evidence that the K-12 student population is becoming increasingly diverse and the teacher workforce is not, very little literature addresses the specific problems rural teacher education programs may experience attempting to meet the National Council for the Accreditation of Teacher Education (NCATE)…

Designing a Self-Contained Group Area Network for Ubiquitous Learning

ERIC Educational Resources Information Center

Chen, Nian-Shing; Kinshuk; Wei, Chun-Wang; Yang, Stephen J. H.

2008-01-01

A number of studies have evidenced that handheld devices are appropriate tools to facilitate face-to-face collaborative learning effectively because of the possibility of ample social interactions. Group Area Network, or GroupNet, proposed in this paper, uses handheld devices to fill the gap between Local Area Network and Body Area Network.…

Twenty-eight years of wilderness campsite monitoring in Yosemite National Park

Treesearch

Laurel Boyers; Mark Fincher; Jan van Wagtendonk

2000-01-01

The research, resource management and wilderness staffs in Yosemite National Park recently completed the third 10-year cycle of a wilderness campsite impact monitoring program. Initial results indicate an overall improvement in conditions due to a strong restoration program, decreased use and increased visitor education. Lessons learned point to the necessity for ample...

School Organizational Contexts, Teacher Turnover, and Student Achievement: Evidence from Panel Data

ERIC Educational Resources Information Center

Kraft, Matthew A.; Marinell, William H.; Yee, Darrick

2015-01-01

In education, there is ample evidence that some schools far outperform others at raising student achievement even when accounting for differences in the students they serve and the resources at their disposal. Differences in the human capital stock of teachers across schools cannot fully account for the differential productivity across schools. In…

Home Literacy Environment and Its Influence on Singaporean Children's Chinese Oral and Written Language Abilities

ERIC Educational Resources Information Center

Li, Li; Tan, Chee Lay

2016-01-01

In a bilingual environment such as Singaporean Chinese community, the challenge of maintaining Chinese language and sustaining Chinese culture lies in promoting the daily use of Chinese language in oral and written forms among children. Ample evidence showed the effect of the home language and literacy environment (HLE), on children's language and…

Developing Pedagogical Judgment in Novice Teachers: Mediated Field Experience as a Pedagogy for Teacher Education

ERIC Educational Resources Information Center

Horn, Ilana Seidel; Campbell, Sara Sunshine

2015-01-01

A common critique of teacher education centres on the gap between coursework and schools, with ample evidence that novice teachers seldom bring ambitious forms of instruction into classroom placements. We describe a 6-year design experiment conducted in a university teacher education program secondary mathematics methods course focused squarely on…

Positronium formation in Ss state in e+-Li scattering

NASA Technical Reports Server (NTRS)

Sarkar, K. P.; Basu, D.; Basu, Madhumita

1990-01-01

There are ample theoretical reasons to investigate positron-alkali atom scattering. Moreover, recent measurement on positron-alkali atom system by a Detroit group has renewed much interest in investigating these processes. Positronium (Ps) formation in excited 2s state in positron-Li scattering at intermediate and high energies were studied including second order effects following Basu and Ghosh.

Strategies for minimizing sample size for use in airborne LiDAR-based forest inventory

USGS Publications Warehouse

Junttila, Virpi; Finley, Andrew O.; Bradford, John B.; Kauranne, Tuomo

2013-01-01

Recently airborne Light Detection And Ranging (LiDAR) has emerged as a highly accurate remote sensing modality to be used in operational scale forest inventories. Inventories conducted with the help of LiDAR are most often model-based, i.e. they use variables derived from LiDAR point clouds as the predictive variables that are to be calibrated using field plots. The measurement of the necessary field plots is a time-consuming and statistically sensitive process. Because of this, current practice often presumes hundreds of plots to be collected. But since these plots are only used to calibrate regression models, it should be possible to minimize the number of plots needed by carefully selecting the plots to be measured. In the current study, we compare several systematic and random methods for calibration plot selection, with the specific aim that they be used in LiDAR based regression models for forest parameters, especially above-ground biomass. The primary criteria compared are based on both spatial representativity as well as on their coverage of the variability of the forest features measured. In the former case, it is important also to take into account spatial auto-correlation between the plots. The results indicate that choosing the plots in a way that ensures ample coverage of both spatial and feature space variability improves the performance of the corresponding models, and that adequate coverage of the variability in the feature space is the most important condition that should be met by the set of plots collected.

A Didactic Sequence of Elementary Geometric Optics Informed by History and Philosophy of Science

ERIC Educational Resources Information Center

Maurício, Paulo; Valente, Bianor; Chagas, Isabel

2017-01-01

The concepts and instruments required for the teaching and learning of geometric optics are introduced in the didactic process without a proper didactic transposition. This claim is secured by the ample evidence of both wide- and deep-rooted alternative concepts on the topic. Didactic transposition is a theory that comes from a reflection on the…

The Fate of a Migrant Language in Northern France (1880-1914): Flemish in Song Repertoire

ERIC Educational Resources Information Center

Declercq, Elien; D'hulst, Lieven

2010-01-01

New research on the history of nineteenth-century Flemish migration into the North of France shows ample evidence of a complex pattern of transfer procedures taking place between the source and target cultures, both via institutions such as newspapers, magazines and associations and via practices such as popular theatre, almanacs and songs. The…

Measuring Officer Knowledge and Experience to Enable Tailored Training

DTIC Science & Technology

2011-11-01

ample evidence to suggest that learning-related individual differences exist (Jensen, 1998; Thorndike , 1985) and that these individual differences...Gottfredson, 1998; Jensen, 1998; Thorndike , 1985). However, general mental ability would seem to affect performance through the acquisition of prior...Psychologist, 27 (1), 5-32. Thorndike , R. L. (1985). The central role of general ability in prediction. Multivariate Behavioral research, 20, 241

Evaluating the Effects of an Applied Learning Exercise on Students' Interest in Social Policy

ERIC Educational Resources Information Center

Weaver, Robert D.; Nackerud, Larry G.

2005-01-01

There is ample evidence that points out that the majority of social work students have little interest in social policy analysis. In this study, the impact a classroom-based policy construction exercise had on the interest level in policy of a differentiated sample (N = 43) of MSW students, in which participants were enrolled in either a…

Reading: Making It Personal Again--Now Serving PIE to Hungry Readers

ERIC Educational Resources Information Center

Hobbs, Nancy; Oleynik, Myra; Sacco, Kristen

2009-01-01

Something wonderful happens when children are asked to choose their own books and are given ample time to read and discuss them. They become hungry readers with an appetite for books! This simple strategy was the basis for developing the program known as PIE (Personalized Independent Enrichment) and its recipe for reading success. The goal of the…

Stable reflexive sheaves of degree zero on Calabi-Yau manifolds

NASA Astrophysics Data System (ADS)

Nakashima, Tohru

2017-11-01

We give sufficient conditions for the existence of μ-stable reflexive sheaves E on a Calabi-Yau threefold such that the first Chern classes c1(E) satisfy c1(E) ṡH2 = 0 for some ample line bundle H. We also prove a result concerning deformations to construct rank two μ-stable sheaves on arbitrary smooth projective varieties.

"Are We Doing Damage?" Choosing an Urban Public School in an Era of Parental Anxiety

ERIC Educational Resources Information Center

Cucchiara, Maia

2013-01-01

There is an ample scholarly and popular literature describing the rise in "anxiety" among middle-class parents. This paper draws from a study of urban middle-class parents who were considering sending their children to public school. Focusing on one neighborhood and its school, it describes the impact of anxiety on the choice process. It further…

Antecedents of Chinese Parents' Autonomy Support and Psychological Control: The Interplay between Parents' Self-Development Socialization Goals and Adolescents' School Performance

ERIC Educational Resources Information Center

Wang, Qian; Chan, Hoi-Wing; Lin, Li

2012-01-01

Despite ample evidence for the benefits of parental autonomy support and the harms of parental psychological control to Chinese adolescents' well-being, little is known about what foreshadows these parenting behaviors among Chinese parents. The current research addressed this gap in the literature. It tested the hypothesis that parents'…

When Neighbours Matter Most: Innovation, Diffusion and State Policy Adoption in Tertiary Education

ERIC Educational Resources Information Center

Cohen-Vogel, Lora; Ingle, William Kyle

2007-01-01

We now have ample evidence that public policies diffuse across the American states; that is, policy adoption is due at least in part to the emulation of policies enacted in nearby states. But, policy adoption is the result of a complex process, a process that often takes years and sometimes decades to complete. According to the "stage"…

Role of oral care to prevent VAP in mechanically ventilated Intensive Care Unit patients.

PubMed

Gupta, A; Gupta, A; Singh, T K; Saxsena, A

2016-01-01

Ventilator associated pneumonia (VAP) is the most common nosocomial infection in Intensive Care Unit. One major factor causing VAP is the aspiration of oral colonization because of poor oral care practices. We feel the role of simple measure like oral care is neglected, despite the ample evidence of it being instrumental in preventing VAP.

Sex Steroid Hormones Matter for Learning and Memory: Estrogenic Regulation of Hippocampal Function Inmale and Female Rodents

ERIC Educational Resources Information Center

Frick, Karyn M.; Kim, Jaekyoon; Tuscher, Jennifer J.; Fortress, Ashley M.

2015-01-01

Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17ß-estradiol (E[subscript 2]), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes…

9 CFR 89.3 - Feeding, watering, and resting livestock in the car.

Code of Federal Regulations, 2013 CFR

2013-01-01

... livestock in the car. 89.3 Section 89.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... livestock in the car. (a) Livestock should be unloaded into pens of the character described in § 89.5(a) for feeding, watering, and resting, unless there is ample room in the car for all of the animals to lie down...

9 CFR 89.3 - Feeding, watering, and resting livestock in the car.

Code of Federal Regulations, 2011 CFR

2011-01-01

... livestock in the car. 89.3 Section 89.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... livestock in the car. (a) Livestock should be unloaded into pens of the character described in § 89.5(a) for feeding, watering, and resting, unless there is ample room in the car for all of the animals to lie down...

9 CFR 89.3 - Feeding, watering, and resting livestock in the car.

Code of Federal Regulations, 2014 CFR

2014-01-01

... livestock in the car. 89.3 Section 89.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... livestock in the car. (a) Livestock should be unloaded into pens of the character described in § 89.5(a) for feeding, watering, and resting, unless there is ample room in the car for all of the animals to lie down...

9 CFR 89.3 - Feeding, watering, and resting livestock in the car.

Code of Federal Regulations, 2012 CFR

2012-01-01

... livestock in the car. 89.3 Section 89.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... livestock in the car. (a) Livestock should be unloaded into pens of the character described in § 89.5(a) for feeding, watering, and resting, unless there is ample room in the car for all of the animals to lie down...

The Children of Mexican Immigrants in U.S. Schools: Exploring Their Parents' and Teachers' Perception and Knowledge Gaps

ERIC Educational Resources Information Center

Janecek, Uvaldina

2012-01-01

The influx of Mexican immigrants has posed enormous challenges to the nation's public school systems where migration is rapidly increasing. The high Hispanic dropout rate points to a failure in educating Latinos and has received ample attention from researchers, educators, and policymakers; but the achievement disparities persist. Using the lens…

Height-growth response to climatic changes differs among populations of Douglas-fir: A novel analysis of historic data

Treesearch

Laura P. Leites; Andrew P. Robinson; Gerald E. Rehfeldt; John D. Marshall; Nicholas L. Crookston

2012-01-01

Projected climate change will affect existing forests, as substantial changes are predicted to occur during their life spans. Species that have ample intraspecific genetic differentiation, such as Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), are expected to display population-specific growth responses to climate change. Using a mixed-effects modeling approach,...

STEM Starts Early: Grounding Science, Technology, Engineering, and Math Education in Early Childhood

ERIC Educational Resources Information Center

McClure, Elisabeth R.; Guernsey, Lisa; Clements, Douglas H.; Bales, Susan Nall; Nichols, Jennifer; Kendall-Taylor, Nat; Levine, Michael H.

2017-01-01

Tomorrow's inventors and scientists are today's curious young children--as long as those children are given ample chances to explore and are guided by adults equipped to support them. "STEM Starts Early" is the culmination of a deep inquiry by the Joan Ganz Cooney Center at Sesame Workshop and New America embarked on an exploratory…

Predicting Success for College Students Enrolled in an Online, Lab-Based, Biology Course for Non-Majors

ERIC Educational Resources Information Center

Foster, Regina

2012-01-01

Online education has exploded in popularity. While there is ample research on predictors of traditional college student success, little research has been done on effective methods of predicting student success in online education. In this study, a number of demographic variables including GPA, ACT, gender, age and others were examined to determine…

STEM Starts Early: Grounding Science, Technology, Engineering, and Math Education in Early Childhood. Executive Summary

ERIC Educational Resources Information Center

McClure, Elisabeth R.; Guernsey, Lisa; Clements, Douglas H.; Bales, Susan Nall; Nichols, Jennifer; Kendall-Taylor, Nat; Levine, Michael H.

2017-01-01

Tomorrow's inventors and scientists are today's curious young children--as long as those children are given ample chances to explore and are guided by adults equipped to support them. "STEM Starts Early" is the culmination of a deep inquiry by the Joan Ganz Cooney Center at Sesame Workshop and New America embarked on an exploratory…

It Is Still a Man's Game--Discrimination of Women in Pay and Promotion

ERIC Educational Resources Information Center

Roach, Bonnie L.

2014-01-01

There is ample evidence that there still is a pay gap amongst men and women and the situation is no different if academia. Many studies have examined various types of gender discrimination in academia and two areas in particular are problematic--salaries and representation of female faculty in upper ranks of academia. This paper examines the past…

(Some) Things Are Different Now: An Optimistic Look at Sexual Prejudice

ERIC Educational Resources Information Center

Kite, Mary E.

2011-01-01

There is ample reason to be discouraged about the prevalence of sexual prejudice. As Herek (2000) notes, the majority of adult respondents in the United States report that homosexual behavior is wrong or "unnatural." The author readily acknowledges, then, that it is overly optimistic to believe that sexual prejudice is a thing of the past or that…

Investigating Bilingual/ESL Teachers' Knowledge and Professional Development Opportunities in a Large Suburban School District in Texas

ERIC Educational Resources Information Center

Franco-Fuenmayor, Susana E.; Padrón, Yolanda N.; Waxman, Hersh C.

2015-01-01

Despite the fact that the population of English Language Learners (ELLs) is rapidly increasing, there is ample evidence that indicates that most teachers can benefit from training for teaching ELLs effectively. The purpose of this study is to examine teachers' knowledge of instructional practices for ELLs, research on bilingual programs,…

Program Innovation in Higher Education: An Exploratory Study of the Creation of New Degree Programs in Chilean Universities

ERIC Educational Resources Information Center

Zapata, Gonzalo

2013-01-01

Many researchers have studied differentiation in higher education systems, considering the multiplicity of new programs as one of its relevant features. In Chile, as well as in Latin America, there is ample literature on emerging higher education institutions and their growing differentiation, but very little or almost none devoted to emerging…

The Importance of Peer Approval in the Sartorial Purchasing Patterns of The University of Georgia Students

ERIC Educational Resources Information Center

Roman, Mallory; Medvedev, Katalin

2011-01-01

There's ample evidence that peer approval and group acceptance play a role in many social phenomena. This influence can manifest itself through the bystander effect, peer pressure, social facilitation and in many other ways. However, dress as a means of social influence has been largely ignored. This study was designed to determine whether peer…

Douglas-fir Progeny Testing for Resistance to Western Spruce Budworm

Treesearch

Geral I. McDonald

1983-01-01

Ample evidence exists that inland populations of Douglas-fir suffer varying amounts of defoliation by western spruce budworm (Johnson and Denton 1975; Williams 1967; McDonald 1981). Such variation in plant insect association can be the result of the plant escaping attack in time and place to actual confrontation between plant and insect (Harris 1980). Co-evolved...

The Organization of Group Care Environments: The Infant Day Care Center.

ERIC Educational Resources Information Center

Cataldo, Michael F.; Risley, Todd R.

In designing group day care for infants, special attention has been given to efficient care practices, so that all the children's health needs can be met and so that the staff will have ample time to interact with the children. One efficient method is to assign each staff member the responsibility of a particular area rather than a particular…

On the Role of Hippocampal Protein Synthesis in the Consolidation and Reconsolidation of Object Recognition Memory

ERIC Educational Resources Information Center

Rossato, Janine I.; Bevilaqua, Lia R. M.; Myskiw, Jociane C.; Medina, Jorge H.; Izquierdo, Ivan; Cammarota, Martin

2007-01-01

Upon retrieval, consolidated memories are again rendered vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led to the hypothesis that memories are reconsolidated at the time of retrieval, and that this depends on protein synthesis. Ample evidence indicates that the hippocampus plays a key role both in…

How Tracking Structures Attitudes towards Ethnic Out-Groups and Interethnic Interactions in the Classroom: An Ethnographic Study in Belgium

ERIC Educational Resources Information Center

Van Praag, Lore; Boone, Simon; Stevens, Peter A. J.; Van Houtte, Mieke

2015-01-01

The influence of the ethnic composition of schools on interethnic relations and attitudes has been studied extensively and has received ample interest from policy makers. However, less attention has been paid to the structures and processes inside schools that organize interethnic relations and attitudes. In Flanders (Belgium), secondary education…

School-to-Work and Inclusion in General Education Teacher Preparation Programs: Instructional Modules for Middle Childhood Subject Area Methods Courses.

ERIC Educational Resources Information Center

Hamill, Lee B.; Geer, Cindy H.

Six instructional modules for middle childhood subject area methods courses are designed to target students in preservice middle childhood general education programs. The modules have been developed for each of the content area methods courses to ensure all preservice teachers have ample exposure to the school-to-work (STW) philosophy and…

Methodological issues in HIV-related social research in Nigeria.

PubMed

Erinosho, Olayiwola; Joseph, Richard; Isiugo-Abanihe, Uche; Dike, Nkem; Aderinto, Adeyinka A

2013-12-01

This paper is about methodological issues in a community-wide study in Nigeria on an infectious disease, namely HIV/AIDS. The study was designed to ascertain the risk factors that contribute to the spread of HIV/AIDS and how that can be tackled in order to bring about behavioural change. The research team believed at the onset that a study on the interplay between HIV/AIDS and sensitive issues like sexual mores and sexuality requires much more than a straightjacket social science method, such as simply doing a cross-section study and/or using interview schedule. This paper reviews the essence of cross-disciplinary approach; team building; as well as the use of a non-participatory observational approach in data collection. It also shows why ample consideration was given to ethical issues which are often glossed over in social research in developing countries. The lessons from the study underscore the methodological imperatives in social research that focus on sensitive issues in largely non-literate context like Nigeria. Although there are formidable challenges in community-based studies in largely non-literate societies, nevertheless they could easily be surmounted if there are ample time and resources to navigate the various sticking points.

A Teacher-Scientist Partnership as a Vehicle to Incorporate Climate Data in Secondary Science Curriculum

NASA Astrophysics Data System (ADS)

Hatheway, B.

2013-12-01

After three years of running a climate science professional development program for secondary teachers, project staff from UCAR and UNC-Greeley have learned the benefits of ample time for interaction between teachers and scientists, informal educators, and their peers. This program gave us the opportunity to develop and refine strategies that leverage teacher-scientist partnerships to improve teachers' ability to teach climate change. First, we prepared both teachers and scientists to work together. Each cohort of teachers took an online course that emphasized climate change content and pedagogy and built a learning community. Scientists were recruited based on their enthusiasm for working with teachers and coached to present materials in an accessible way. Second, the teachers and scientists collaborated during a four-week summer workshop at UCAR. During the workshop, teachers met with a wide range of climate and atmospheric scientists to learn about research, selected a specific scientist's research they would like to adapt for their classrooms, and developed and refined activities based on that research. The program includes strong mentoring from a team of science educators, structured peer feedback, and ample opportunity to interact with the scientists by asking questions, accessing data, or checking resources. This new model of professional development fosters teacher-scientist partnerships. By the end of the four-week workshop, the teachers have built customized activities based on the cutting-edge research being conducted by participating scientists, developed plans to implement and assess those activities, and further strengthened the learning-community that they will rely on for support during the following academic year. This session will provide information about how this model, which differs from the more common model of engaging teachers in research under the direction of scientists, was successful and accomplished positive outcomes for both the teachers and scientists who participated. Lessons learned that will improve this model will also be discussed.

Comparison of the safety-related physical and combustion properties of liquid hydrogen and liquid natural gas in the context of the SF-BREEZE high-speed fuel-cell ferry

DOE PAGES

Klebanoff, L. E.; Pratt, J. W.; LaFleur, C. B.

2016-11-25

Here, we review liquid hydrogen (LH 2) as a maritime vessel fuel, from descriptions of its fundamental properties to its practical application and safety aspects, in the context of the San Francisco Bay Renewable Energy Electric Vessel with Zero Emissions (SF-BREEZE) high-speed fuel-cell ferry. Since marine regulations have been formulated to cover liquid natural gas (LNG) as a primary propulsion fuel, we frame our examination of LH 2 as a comparison to LNG, for both maritime use in general, and the SF-BREEZE in particular. Due to weaker attractions between molecules, LH 2 is colder than LNG, and evaporates more easily.more » We describe the consequences of these physical differences for the size and duration of spills of the two cryogenic fuels. The classical flammability ranges are reviewed, with a focus on how fuel buoyancy modifies these combustion limits. We examine the conditions for direct fuel explosion (detonation) and contrast them with initiation of normal (laminar) combustion. Direct fuel detonation is not a credible accident scenario for the SF-BREEZE. For both fuels, we review experiments and theory elucidating the deflagration to detonation transition (DDT). LH 2 fires have a shorter duration than energy-equivalent LNG fires, and produce significantly less thermal radiation. The thermal (infrared) radiation from hydrogen fires is also strongly absorbed by humidity in the air. Hydrogen permeability is not a leak issue for practical hydrogen plumbing. We describe the chemistry of hydrogen and methane at iron surfaces, clarifying their impact on steel-based hydrogen storage and transport materials. These physical, chemical and combustion properties are pulled together in a comparison of how a LH 2 or LNG pool fire on the Top Deck of the SF-BREEZE might influence the structural integrity of the aluminum deck. Neither pool fire scenario leads to net heating of the aluminum decking. Overall, LH 2 and LNG are very similar in their physical and combustion properties, thereby posing similar safety risks. For ships utilizing LH 2 or LNG, precautions are needed to avoid fuel leaks, minimize ignition sources, minimize confined spaces, provide ample ventilation for required confined spaces, and to monitor the enclosed spaces to ensure any fuel accumulation is detected far below the fuel/air mix threshold for any type of combustion.« less

Comparison of the safety-related physical and combustion properties of liquid hydrogen and liquid natural gas in the context of the SF-BREEZE high-speed fuel-cell ferry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klebanoff, L. E.; Pratt, J. W.; LaFleur, C. B.

Here, we review liquid hydrogen (LH 2) as a maritime vessel fuel, from descriptions of its fundamental properties to its practical application and safety aspects, in the context of the San Francisco Bay Renewable Energy Electric Vessel with Zero Emissions (SF-BREEZE) high-speed fuel-cell ferry. Since marine regulations have been formulated to cover liquid natural gas (LNG) as a primary propulsion fuel, we frame our examination of LH 2 as a comparison to LNG, for both maritime use in general, and the SF-BREEZE in particular. Due to weaker attractions between molecules, LH 2 is colder than LNG, and evaporates more easily.more » We describe the consequences of these physical differences for the size and duration of spills of the two cryogenic fuels. The classical flammability ranges are reviewed, with a focus on how fuel buoyancy modifies these combustion limits. We examine the conditions for direct fuel explosion (detonation) and contrast them with initiation of normal (laminar) combustion. Direct fuel detonation is not a credible accident scenario for the SF-BREEZE. For both fuels, we review experiments and theory elucidating the deflagration to detonation transition (DDT). LH 2 fires have a shorter duration than energy-equivalent LNG fires, and produce significantly less thermal radiation. The thermal (infrared) radiation from hydrogen fires is also strongly absorbed by humidity in the air. Hydrogen permeability is not a leak issue for practical hydrogen plumbing. We describe the chemistry of hydrogen and methane at iron surfaces, clarifying their impact on steel-based hydrogen storage and transport materials. These physical, chemical and combustion properties are pulled together in a comparison of how a LH 2 or LNG pool fire on the Top Deck of the SF-BREEZE might influence the structural integrity of the aluminum deck. Neither pool fire scenario leads to net heating of the aluminum decking. Overall, LH 2 and LNG are very similar in their physical and combustion properties, thereby posing similar safety risks. For ships utilizing LH 2 or LNG, precautions are needed to avoid fuel leaks, minimize ignition sources, minimize confined spaces, provide ample ventilation for required confined spaces, and to monitor the enclosed spaces to ensure any fuel accumulation is detected far below the fuel/air mix threshold for any type of combustion.« less

Validation of Procedures for Monitoring Crewmember Immune Function SDBI-1900, SMO-015 - Integrated Immune

NASA Technical Reports Server (NTRS)

Crucian, Brian; Stowe, Raymond; Mehta, Satish; Uchakin, Peter; Nehlsen-Cannarella, Sandra; Morukov, Boris; Pierson, Duane; Sams, Clarence

2007-01-01

There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. The clinical risk from prolonged immune dysregulation during space flight are not yet determined, but may include increased incidence of infection, allergy, hypersensitivity, hematological malignancy or altered wound healing. Each of the clinical events resulting from immune dysfunction has the potential to impact mission critical objectives during exploration-class missions. To date, precious little in-flight immune data has been generated to assess this phenomenon. The majority of recent flight immune studies have been post-flight assessments, which may not accurately reflect the in-flight condition. There are no procedures currently in place to monitor immune function or its effect on crew health. The objective of this Supplemental Medical Objective (SMO) is to develop and validate an immune monitoring strategy consistent with operational flight requirements and constraints. This SMO will assess the clinical risks resulting from the adverse effects of space flight on the human immune system and will validate a flight-compatible immune monitoring strategy. Characterization of the clinical risk and the development of a monitoring strategy are necessary prerequisite activities prior to validating countermeasures. This study will determine, to the best level allowed by current technology, the in-flight status of crewmembers immune system. Pre-flight, in-flight and post-flight assessments of immune status, immune function, viral reactivation and physiological stress will be performed. The in-flight samples will allow a distinction between legitimate in-flight alterations and the physiological stresses of landing and readaptation which are believed to alter landing day assessments. The overall status of the immune system during flight (activation, deficiency, dysregulation) and the response of the immune system to specific latent virus reactivation (known to occur during space flight) will be thoroughly assessed. Following completion of the SMO the data will be evaluated to determine the optimal set of assays for routine monitoring of crewmember immune system function, should the clinical risk warrant such monitoring.

Secondary Metabolites from Three Florida Sponges with Antidepressant Activity

PubMed Central

Kochanowska, Anna J.; Rao, Karumanchi V.; Childress, Suzanne; El-Alfy, Abir; Matsumoto, Rae R.; Kelly, Michelle; Stewart, Gina S.; Sufka, Kenneth J.; Hamann, Mark T.

2016-01-01

Brominated indole alkaloids are a common class of metabolites reported from sponges of the order Verongida. Herein we report the isolation, structure determination, and activity of metabolites from three Florida sponges, namely, Verongula rigida (order Verongida, family Aplysinidae), Smenospongia aurea, and S. cerebriformis (order Dictyoceratida, family Thorectidae). All three species were investigated chemically, revealing similarities in secondary metabolites. Brominated compounds, as well as sesquiterpene quinones and hydroquinones, were identified from both V. rigida and S. aurea despite their apparent taxonomic differences at the ordinal level. Similar metabolites found in these distinct sponge species of two different genera provide evidence for a microbial origin of the metabolites. Isolated compounds were evaluated in the Porsolt forced swim test (FST) and the chick anxiety–depression continuum model. Among the isolated compounds, 5,6-dibromo-N,N-dimethyltryptamine (1) exhibited significant antidepressant-like action in the rodent FST model, while 5-bromo-N,N-dimethyltryptamine (2) caused significant reduction of locomotor activity indicative of a potential sedative action. The current study provides ample evidence that marine natural products with the diversity of brominated marine alkaloids will provide potential leads for antidepressant and anxiolytic drugs. PMID:18217716

Biotech Outsourcing Strategies cmc—Biologics stream

PubMed Central

2010-01-01

Now in its third year, the Biotech Outsourcing Strategies (BOS) meeting organized by Bio2Business took place at the Søhuset Conference Centre in Hørsholm, Copenhagen. The focus of this year's event was the demanding and challenging area of chemistry, manufacturing and controls (CMC), and the meeting provided ample opportunity for lively discussion of the key issues surrounding this area. New for the 2010 conference, a biologics-focused lecture stream ran in parallel to the established small molecule stream. Both streams boasted a distinguished panel of keynote speakers who discussed all aspects of CMC from early stage scale-up through late stage clinical development. In addition to the keynote speakers, selected contract research organizations (CROs) gave short presentations on the solutions that they could provide to some of the challenges facing CMC. The meeting attracted more than 150 delegates from leading drug development companies and CRO service providers, and greatly facilitated the forging of new working relationships through pre-arranged one-to-one meetings. Moreover, exhibitions from event sponsors and considerable scheduled networking time over lunch and evening receptions further enhanced the highly productive and interactive nature of the meeting. PMID:20716956

Biotech outsourcing strategies cmc--biologics stream. June 17, 2010, Copenhagen, Denmark.

PubMed

Hamer, Kate

2010-01-01

Now in its third year, the Biotech Outsourcing Strategies (BOS) meeting organized by Bio2Business took place at the Søhuset Conference Centre in Hørsholm, Copenhagen. The focus of this year's event was the demanding and challenging area of chemistry, manufacturing and controls (CMC), and the meeting provided ample opportunity for lively discussion of the key issues surrounding this area. New for the 2010 conference, a biologics-focused lecture stream ran in parallel to the established small molecule stream. Both streams boasted a distinguished panel of keynote speakers who discussed all aspects of CMC from early stage scale-up through late stage clinical development. In addition to the keynote speakers, selected contract research organizations (CROs) gave short presentations on the solutions that they could provide to some of the challenges facing CMC. The meeting attracted more than 150 delegates from leading drug development companies and CRO service providers, and greatly facilitated the forging of new working relationships through pre-arranged one-to-one meetings. Moreover, exhibitions from event sponsors and considerable scheduled networking time over lunch and evening reception further enhanced the highly productive and interactive nature of the meeting.

Family environment and pediatric overweight: what is a parent to do?

PubMed

Ritchie, Lorrene D; Welk, Greg; Styne, Dennis; Gerstein, Dana E; Crawford, Patricia B

2005-05-01

Although the causes of pediatric overweight are many and the levels of intervention required to prevent overweight in children extend from the child's immediate environment to the larger societal level, one critical intervention target is the parent. Scientific evidence points to specific dietary and physical activity/inactivity behaviors that families can adopt to encourage healthful weight status. Dietary recommendations include providing children with ample access to nutrient-dense foods and beverages and high-fiber foods, both at meals and snack times, reducing children's access to high-calorie, nutrient-poor beverages and foods both when eating at home and at restaurants, avoiding excessive food restriction or use of food as a reward, and encouraging children to eat breakfast on a daily basis. Physical activity recommendations include providing opportunities and encouragement for children to be physically active while reducing children's television and video game time. Parental modeling of healthful eating and physical activity practices is recommended to reinforce these patterns in youth. Dietetics professionals, physicians, and other health care professionals can assist parents in their efforts to prevent pediatric overweight by providing information and supporting these key behaviors, while working to create environments that support healthful lifestyle changes.

The human resource crisis in neuro-ophthalmology.

PubMed

Frohman, Larry P

2008-09-01

Neuro-ophthalmology is facing a serious human resource issue. Few are entering the subspecialty, which is perceived as being poorly compensated compared with other subspecialties of ophthalmology. The low compensation comes from the fact that 1) non-procedural encounters remain undervalued, 2) efforts that benefit other medical specialists are not counted, and 3) the relatively low expenses of neuro-ophthalmologists are not factored into compensation formulas. Mission-based budgeting, which forces academic departments to be financially accountable without the expectation of fiscal relief from medical schools or practice plans, has exacerbated the compensation issue. Solutions must come from within neuro-ophthalmology, academic departments, medical schools, and medical practice plans. They include 1) providing educational resources so that neuro-ophthalmologists need not spend so much time teaching the basics, 2) factoring into compensation the impact of neuro-ophthalmologists in teaching and on revenue generation by procedure-based specialists, 3) improving the efficiency of neuro-ophthalmologists in their consultative practices by providing ample clerical support and other measures, 4) providing contractual salary compensation by departments such as neurosurgery to recognize the contributions made by neuro-ophthalmologists, and 5) reorganizing the academic clinical effort as multidisciplinary rather than departmental.

Differentiating Ferroelectric and Nonferroelectric Electromechanical Effects with Scanning Probe Microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balke, Nina; Maksymovych, Petro; Jesse, Stephen

Ferroelectricity in functional materials remains one of the most fascinating areas of modern science in the past several decades. In the last several years, the rapid development of piezoresponse force microscopy (PFM) and spectroscopy revealed the presence of electromechanical hysteresis loops and bias-induced remnant polar states in a broad variety of materials including many inorganic oxides, polymers, and biosystems. In many cases, this behavior was interpreted as the ample evidence for ferroelectric nature of the system. Here, we systematically analyze PFM responses on ferroelectric and nonferroelectric materials and demonstrate that mechanisms unrelated to ferroelectricity can induce ferroelectric-like characteristics through chargemore » injection and electrostatic forces on the tip. In this paper, we will focus on similarities and differences in various PFM measurement characteristics to provide an experimental guideline to differentiate between ferroelectric material properties and charge injection. In conclusion, we apply the developed measurement protocols to an unknown ferroelectric material.« less

Differentiating Ferroelectric and Nonferroelectric Electromechanical Effects with Scanning Probe Microscopy

DOE PAGES

Balke, Nina; Maksymovych, Petro; Jesse, Stephen; ...

2015-06-02

Ferroelectricity in functional materials remains one of the most fascinating areas of modern science in the past several decades. In the last several years, the rapid development of piezoresponse force microscopy (PFM) and spectroscopy revealed the presence of electromechanical hysteresis loops and bias-induced remnant polar states in a broad variety of materials including many inorganic oxides, polymers, and biosystems. In many cases, this behavior was interpreted as the ample evidence for ferroelectric nature of the system. Here, we systematically analyze PFM responses on ferroelectric and nonferroelectric materials and demonstrate that mechanisms unrelated to ferroelectricity can induce ferroelectric-like characteristics through chargemore » injection and electrostatic forces on the tip. In this paper, we will focus on similarities and differences in various PFM measurement characteristics to provide an experimental guideline to differentiate between ferroelectric material properties and charge injection. In conclusion, we apply the developed measurement protocols to an unknown ferroelectric material.« less

Multitrace/singletrace formulations and Domain Decomposition Methods for the solution of Helmholtz transmission problems for bounded composite scatterers

NASA Astrophysics Data System (ADS)

Jerez-Hanckes, Carlos; Pérez-Arancibia, Carlos; Turc, Catalin

2017-12-01

We present Nyström discretizations of multitrace/singletrace formulations and non-overlapping Domain Decomposition Methods (DDM) for the solution of Helmholtz transmission problems for bounded composite scatterers with piecewise constant material properties. We investigate the performance of DDM with both classical Robin and optimized transmission boundary conditions. The optimized transmission boundary conditions incorporate square root Fourier multiplier approximations of Dirichlet to Neumann operators. While the multitrace/singletrace formulations as well as the DDM that use classical Robin transmission conditions are not particularly well suited for Krylov subspace iterative solutions of high-contrast high-frequency Helmholtz transmission problems, we provide ample numerical evidence that DDM with optimized transmission conditions constitute efficient computational alternatives for these type of applications. In the case of large numbers of subdomains with different material properties, we show that the associated DDM linear system can be efficiently solved via hierarchical Schur complements elimination.

Childhood pregnancy as a result of incest: a case report and literature review with suggested management strategies.

PubMed

Stechna, Sharon B

2011-06-01

Childhood pregnancy presents multiple challenges, which are compounded when the pregnancy is a result of abuse. While there is ample information regarding the psychological manifestations of childhood sexual abuse, a review of the literature provides modest information on childhood pregnancy, as distinct from teen pregnancy. A 10-year-old pregnant female reports for medical care at 28-30 weeks gestation. Sensitivity to the patient's and family's needs and having a care team who followed a well defined care plan appeared to be the key to optimizing the management of this patient. Although decisions should be based on medical standards, the psychological, social, and, at times, criminal concerns must be considered in every aspect of the patient's care and variations from established patterns of care should be allowed when needed. Copyright © 2011 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Chest wall reconstruction using iliac bone allografts and muscle flaps.

PubMed

Garcia-Tutor, Emilio; Yeste, Luis; Murillo, Julio; Aubá, Cristina; Sanjulian, Mikel; Torre, Wenceslao

2004-01-01

Technically we can divide full-thickness thoracic reconstruction into 2 parts: providing a rigid support and ensuring well-vascularized coverage. Since 1986, the authors' center has had ample experience with bone banks and the use of cryopreserved bone grafts, which led them to consider the possibility of using these grafts for full-thickness chest wall reconstruction. They describe 3 patients in whom resection of the tumor and reconstruction of the thorax were carried out using iliac bone allografts covered with muscle flaps (1 pectoralis major and 2 rectus abdominis). None of the patients experienced breathing difficulties, pain, or instability after 14 months, 18 months, and 11 years of follow-up. The result of the reconstruction was excellent in all 3 patients in terms of function and aesthetics. The advantage of allografts compared with synthetic materials is their potential integration; they can become part of the host patient's living tissue.

Is More Always Better in Designing Workplace Wellness Programs?: A Comparison of Wellness Program Components Versus Outcomes.

PubMed

Batorsky, Benjamin; Van Stolk, Christian; Liu, Hangsheng

2016-10-01

Assess whether adding more components to a workplace wellness program is associated with better outcomes by measuring the relationship of program components to one another and to employee participation and perceptions of program effectiveness. Data came from a 2014 survey of 24,393 employees of 81 employers about services offered, leadership, incentives, and promotion. Logistic regressions were used to model the relationship between program characteristics and outcomes. Components individually are related to better outcomes, but this relationship is weaker in the presence of other components and non-significant for incentives. Within components, a moderate level of services and work time participation opportunities are associated with higher participation and effectiveness. The "more of everything" approach does not appear to be advisable for all programs. Programs should focus on providing ample opportunities for employees to participate and initiatives like results-based incentives.

Hawking temperature: an elementary approach based on Newtonian mechanics and quantum theory

NASA Astrophysics Data System (ADS)

Pinochet, Jorge

2016-01-01

In 1974, the British physicist Stephen Hawking discovered that black holes have a characteristic temperature and are therefore capable of emitting radiation. Given the scientific importance of this discovery, there is a profuse literature on the subject. Nevertheless, the available literature ends up being either too simple, which does not convey the true physical significance of the issue, or too technical, which excludes an ample segment of the audience interested in science, such as physics teachers and their students. The present article seeks to remedy this shortcoming. It develops a simple and plausible argument that provides insight into the fundamental aspects of Hawking’s discovery, which leads to an approximate equation for the so-called Hawking temperature. The exposition is mainly intended for physics teachers and their students, and it only requires elementary algebra, as well as basic notions of Newtonian mechanics and quantum theory.

Individual differences in intrinsic brain connectivity predict decision strategy.

PubMed

Barnes, Kelly Anne; Anderson, Kevin M; Plitt, Mark; Martin, Alex

2014-10-15

When humans are provided with ample time to make a decision, individual differences in strategy emerge. Using an adaptation of a well-studied decision making paradigm, motion direction discrimination, we probed the neural basis of individual differences in strategy. We tested whether strategies emerged from moment-to-moment reconfiguration of functional brain networks involved in decision making with task-evoked functional MRI (fMRI) and whether intrinsic properties of functional brain networks, measured at rest with functional connectivity MRI (fcMRI), were associated with strategy use. We found that human participants reliably selected one of two strategies across 2 days of task performance, either continuously accumulating evidence or waiting for task difficulty to decrease. Individual differences in decision strategy were predicted both by the degree of task-evoked activation of decision-related brain regions and by the strength of pretask correlated spontaneous brain activity. These results suggest that spontaneous brain activity constrains strategy selection on perceptual decisions.

The validity and clinical utility of purging disorder.

PubMed

Keel, Pamela K; Striegel-Moore, Ruth H

2009-12-01

To review evidence of the validity and clinical utility of Purging Disorder and examine options for the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-V). Articles were identified by computerized and manual searches and reviewed to address five questions about Purging Disorder: Is there "ample" literature? Is the syndrome clearly defined? Can it be measured and diagnosed reliably? Can it be differentiated from other eating disorders? Is there evidence of syndrome validity? Although empirical classification and concurrent validity studies provide emerging support for the distinctiveness of Purging Disorder, questions remain about definition, diagnostic reliability in clinical settings, and clinical utility (i.e., prognostic validity). We discuss strengths and weaknesses associated with various options for the status of Purging Disorder in the DSM-V ranging from making no changes from DSM-IV to designating Purging Disorder a diagnosis on equal footing with Anorexia Nervosa and Bulimia Nervosa.

Aerodynamic characteristics of a canard-controlled missile at Mach numbers of 1.5 and 2.0.

NASA Technical Reports Server (NTRS)

Kassner, D. L.; Wettlaufer, B.

1977-01-01

A typical missile model with nose mounted canards and cruciform tail surfaces was tested in the Ames 6- by 6-Foot Wind Tunnel to determine the contributions of the component aerodynamic surfaces to the static aerodynamic characteristics at Mach numbers of 1.5 and 2.0 and Reynolds number of 1 million based on body diameter. Data were obtained at angles of attack ranging from -3 deg to 12 deg for various stages of model build-up (i.e., with and without canard and/or tail surfaces). Results were obtained both with the model unrolled and rolled 45 deg. For the canard and tail arrangements investigated, the model was trimmable at angles of attack up to about 10 deg with canard deflections of 9 deg. Also, the tail arrangements studied provided ample pitch stability. there were no appreciable effects of model roll orientation.

Aerodynamic characteristics of a canard-controlled missile at Mach numbers of 0.8, 1.3, and 1.75. [in the Ames 6 by 6 foot wind tunnel

NASA Technical Reports Server (NTRS)

Kassner, D. L.; Wettlaufer, B.

1977-01-01

A typical missile model with nose-mounted canards and cruciform tail surfaces was tested in the Ames 6- by 6-Foot Wind Tunnel to determine the contributions of the component aerodynamic surfaces to the static aerodynamic characteristics at Mach numbers of 0.8, 1.3, and 1.75 and Reynolds number of 625,000 based on body diameter. Data were obtained at angles of attack ranging from 0 deg to 24 deg for various stages of model build-up (i.e., with and without canard and/or tail surfaces). In addition, two different sets of canards and tail surfaces were investigated. For the canard and tail arrangements investigated, the model was trimmable at angles of attack up to about 7 deg with canard deflections of about 10 deg. Also, the tail arrangements studied provided ample pitch stability.

Arthropods of medicoveterinary importance in zoos.

PubMed

Adler, Peter H; Tuten, Holly C; Nelder, Mark P

2011-01-01

Zoos present a unique assemblage of arthropods, captive vertebrates, free-roaming wildlife, humans, and plants, each with its own biota of symbiotic organisms. Arthropods of medicoveterinary importance are well represented in zoos, and an ample literature documents their influence in these animal-rich environments. Mosquitoes are of greatest significance because of the animal and human pathogens they transmit, followed by ectoparasites, many of which are exotic and present health risks to captive and native animals. Biting flies, cockroaches, filth flies, and triatomid bugs represent additional concerns. Integrated management programs for arthropods in zoos are commonplace. Zoos can play a role in biosurveillance, serving as an advanced guard for detecting exotic arthropods and vector-borne diseases. We provide the first review of arthropods of medicoveterinary importance in zoos. A case is made for the value of collaborations between entomologists and zoo personnel as a means of enhancing research and public education while safeguarding the health of captive animals and the public.

Bioinformatics: perspectives for the future.

PubMed

Costa, Luciano da Fontoura

2004-12-30

I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex networks as a powerful and flexible framework for bioinformatics and the interplay between bio- and neuroinformatics. Human resource formation and market perspective are also addressed. Given the complexity and vastness of these issues and concepts, as well as the limited size of a scientific article and finite patience of the reader, these perspectives are surely incomplete and biased. However, it is expected that some of the questions and trends that are identified will motivate discussions during the IcoBiCoBi round table (with the same name as this article) and perhaps provide a more ample perspective among the participants of that conference and the readers of this text.

Detection of functionally important regions in "hypothetical proteins" of known structure.

PubMed

Nimrod, Guy; Schushan, Maya; Steinberg, David M; Ben-Tal, Nir

2008-12-10

Structural genomics initiatives provide ample structures of "hypothetical proteins" (i.e., proteins of unknown function) at an ever increasing rate. However, without function annotation, this structural goldmine is of little use to biologists who are interested in particular molecular systems. To this end, we used (an improved version of) the PatchFinder algorithm for the detection of functional regions on the protein surface, which could mediate its interactions with, e.g., substrates, ligands, and other proteins. Examination, using a data set of annotated proteins, showed that PatchFinder outperforms similar methods. We collected 757 structures of hypothetical proteins and their predicted functional regions in the N-Func database. Inspection of several of these regions demonstrated that they are useful for function prediction. For example, we suggested an interprotein interface and a putative nucleotide-binding site. A web-server implementation of PatchFinder and the N-Func database are available at http://patchfinder.tau.ac.il/.